A FAST PROPAGATING EXTREME-ULTRAVIOLET WAVE ASSOCIATED WITH A MINI-FILAMENT ERUPTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng Ruisheng; Jiang Yunchun; Yang Jiayan

The fast extreme-ultraviolet (EUV) waves (>1000 km s{sup -1}) in the solar corona were very rare in the past. Taking advantage of the high temporal and spatial resolution of the Solar Dynamics Observatory observations, we present a fast EUV wave associated with a mini-filament eruption, a C1.0 flare, and a coronal mass ejection (CME) on 2011 September 30. The event took place at the periphery between two active regions (ARs). The mini-filament rapidly erupted as a blowout jet associated with a flare and a CME. The CME front was likely developed from the large-scale overlying loops. The wave onset wasmore » nearly simultaneous with the start of the jet and the flare. The wave departed far from the flare center and showed a close location relative to the rapid jet. The wave had an initial speed of about 1100 km s{sup -1} and a slight deceleration in the last phase, and the velocity decreased to about 500 km s{sup -1}. The wave propagated in a narrow angle extent, likely to avoid the ARs on both sides. All the results provide evidence that the fast EUV wave was a fast-mode MHD wave. The wave resisted being driven by the CME, because it opened up the large-scale loops and its front likely formed later than the wave. The wave was most likely triggered by the jet, due to their close timing and location relations.« less

The Need for Optical Means as an Alternative for Electronic Computing

NASA Technical Reports Server (NTRS)

Adbeldayem, Hossin; Frazier, Donald; Witherow, William; Paley, Steve; Penn, Benjamin; Bank, Curtis; Whitaker, Ann F. (Technical Monitor)

2001-01-01

An increasing demand for faster computers is rapidly growing to encounter the fast growing rate of Internet, space communication, and robotic industry. Unfortunately, the Very Large Scale Integration technology is approaching its fundamental limits beyond which the device will be unreliable. Optical interconnections and optical integrated circuits are strongly believed to provide the way out of the extreme limitations imposed on the growth of speed and complexity of nowadays computations by conventional electronics. This paper demonstrates two ultra-fast, all-optical logic gates and a high-density storage medium, which are essential components in building the future optical computer.

Chest Ultrasonography in Modern Day Extreme Settings: From Military Setting and Natural Disasters to Space Flights and Extreme Sports

PubMed Central

Mucci, Viviana

2018-01-01

Chest ultrasonography (CU) is a noninvasive imaging technique able to provide an immediate diagnosis of the underlying aetiology of acute respiratory failure and traumatic chest injuries. Given the great technologies, it is now possible to perform accurate CU in remote and adverse environments including the combat field, extreme sport settings, and environmental disasters, as well as during space missions. Today, the usage of CU in the extreme emergency setting is more likely to occur, as this technique proved to be a fast diagnostic tool to assist resuscitation manoeuvres and interventional procedures in many cases. A scientific literature review is presented here. This was based on a systematic search of published literature, on the following online databases: PubMed and Scopus. The following words were used: “chest sonography,” “ thoracic ultrasound,” and “lung sonography,” in different combinations with “extreme sport,” “extreme environment,” “wilderness,” “catastrophe,” and “extreme conditions.” This manuscript reports the most relevant usages of CU in the extreme setting as well as technological improvements and current limitations. CU application in the extreme setting is further encouraged here. PMID:29736195

Enabling fast charging – Battery thermal considerations

DOE PAGES

Keyser, Matthew; Pesaran, Ahmad; Li, Qibo; ...

2017-10-23

Battery thermal barriers are reviewed with regards to extreme fast charging. Present-day thermal management systems for battery electric vehicles are inadequate in limiting the maximum temperature rise of the battery during extreme fast charging. If the battery thermal management system is not designed correctly, the temperature of the cells could reach abuse temperatures and potentially send the cells into thermal runaway. Furthermore, the cell and battery interconnect design needs to be improved to meet the lifetime expectations of the consumer. Each of these aspects is explored and addressed as well as outlining where the heat is generated in a cell,more » the efficiencies of power and energy cells, and what type of battery thermal management solutions are available in today’s market. Here, thermal management is not a limiting condition with regard to extreme fast charging, but many factors need to be addressed especially for future high specific energy density cells to meet U.S. Department of Energy cost and volume goals.« less

Enabling fast charging – Battery thermal considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keyser, Matthew; Pesaran, Ahmad; Li, Qibo

Battery thermal barriers are reviewed with regards to extreme fast charging. Present-day thermal management systems for battery electric vehicles are inadequate in limiting the maximum temperature rise of the battery during extreme fast charging. If the battery thermal management system is not designed correctly, the temperature of the cells could reach abuse temperatures and potentially send the cells into thermal runaway. Furthermore, the cell and battery interconnect design needs to be improved to meet the lifetime expectations of the consumer. Each of these aspects is explored and addressed as well as outlining where the heat is generated in a cell,more » the efficiencies of power and energy cells, and what type of battery thermal management solutions are available in today’s market. Here, thermal management is not a limiting condition with regard to extreme fast charging, but many factors need to be addressed especially for future high specific energy density cells to meet U.S. Department of Energy cost and volume goals.« less

The subdwarf B star SB 290 - A fast rotator on the extreme horizontal branch

NASA Astrophysics Data System (ADS)

Geier, S.; Heber, U.; Heuser, C.; Classen, L.; O'Toole, S. J.; Edelmann, H.

2013-03-01

Hot subdwarf B stars (sdBs) are evolved core helium-burning stars with very thin hydrogen envelopes. To form an sdB, the progenitor has to lose almost all of its hydrogen envelope right at the tip of the red giant branch. In close binary systems, mass transfer to the companion provides the extraordinary mass loss required for their formation. However, apparently single sdBs exist as well, and their formation has been unclear for decades. The merger of helium white dwarfs leading to an ignition of core helium-burning or the merger of a helium core and a low-mass star during the common envelope phase have been proposed. Here we report the discovery of SB 290 as the first apparently single, fast-rotating sdB star located on the extreme horizontal branch, indicating that those stars may form from mergers. Appendix A is available in electronic form at http://www.aanda.org

Perception, Action, and Cognition of Football Referees in Extreme Temperatures: Impact on Decision Performance.

PubMed

Gaoua, Nadia; de Oliveira, Rita F; Hunter, Steve

2017-01-01

Different professional domains require high levels of physical performance alongside fast and accurate decision-making. Construction workers, police officers, firefighters, elite sports men and women, the military and emergency medical professionals are often exposed to hostile environments with limited options for behavioral coping strategies. In this (mini) review we use football refereeing as an example to discuss the combined effect of intense physical activity and extreme temperatures on decision-making and suggest an explicative model. In professional football competitions can be played in temperatures ranging from -5°C in Norway to 30°C in Spain for example. Despite these conditions, the referee's responsibility is to consistently apply the laws fairly and uniformly, and to ensure the rules are followed without waning or adversely influencing the competitiveness of the play. However, strenuous exercise in extreme environments imposes increased physiological and psychological stress that can affect decision-making. Therefore, the physical exertion required to follow the game and the thermal strain from the extreme temperatures may hinder the ability of referees to make fast and accurate decisions. Here, we review literature on the physical and cognitive requirements of football refereeing and how extreme temperatures may affect referees' decisions. Research suggests that both hot and cold environments have a negative impact on decision-making but data specific to decision-making is still lacking. A theoretical model of decision-making under the constraint of intense physical activity and thermal stress is suggested. Future naturalistic studies are needed to validate this model and provide clear recommendations for mitigating strategies.

Perception, Action, and Cognition of Football Referees in Extreme Temperatures: Impact on Decision Performance

PubMed Central

Gaoua, Nadia; de Oliveira, Rita F.; Hunter, Steve

2017-01-01

Different professional domains require high levels of physical performance alongside fast and accurate decision-making. Construction workers, police officers, firefighters, elite sports men and women, the military and emergency medical professionals are often exposed to hostile environments with limited options for behavioral coping strategies. In this (mini) review we use football refereeing as an example to discuss the combined effect of intense physical activity and extreme temperatures on decision-making and suggest an explicative model. In professional football competitions can be played in temperatures ranging from -5°C in Norway to 30°C in Spain for example. Despite these conditions, the referee’s responsibility is to consistently apply the laws fairly and uniformly, and to ensure the rules are followed without waning or adversely influencing the competitiveness of the play. However, strenuous exercise in extreme environments imposes increased physiological and psychological stress that can affect decision-making. Therefore, the physical exertion required to follow the game and the thermal strain from the extreme temperatures may hinder the ability of referees to make fast and accurate decisions. Here, we review literature on the physical and cognitive requirements of football refereeing and how extreme temperatures may affect referees’ decisions. Research suggests that both hot and cold environments have a negative impact on decision-making but data specific to decision-making is still lacking. A theoretical model of decision-making under the constraint of intense physical activity and thermal stress is suggested. Future naturalistic studies are needed to validate this model and provide clear recommendations for mitigating strategies. PMID:28912742

Extreme Magnetic Storms: Their Characteristics and Possible Consequences for Humanity

NASA Astrophysics Data System (ADS)

Falkowski, B. J.; Tsurutani, B.; Lakhina, G. S.; Deng, Y.; Mannucci, A. J.

2015-12-01

The solar and interplanetary conditions necessary to create an extreme magnetic storm will be discussed. The Carrington 1859 event was not the largest possible. It will be shown that different facets of fast ICMEs/extreme magnetic storms will have different limitations. Some possible adverse effects of such extreme space weather events on society will be addressed.

Extreme ultra-violet movie camera for imaging microsecond time scale magnetic reconnection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chai, Kil-Byoung; Bellan, Paul M.

2013-12-15

An ultra-fast extreme ultra-violet (EUV) movie camera has been developed for imaging magnetic reconnection in the Caltech spheromak/astrophysical jet experiment. The camera consists of a broadband Mo:Si multilayer mirror, a fast decaying YAG:Ce scintillator, a visible light block, and a high-speed visible light CCD camera. The camera can capture EUV images as fast as 3.3 × 10{sup 6} frames per second with 0.5 cm spatial resolution. The spectral range is from 20 eV to 60 eV. EUV images reveal strong, transient, highly localized bursts of EUV radiation when magnetic reconnection occurs.

Proliferating Myositis: An Inflammatory Lesion often Misdiagnosed as A Malignant Tumor.

PubMed

Binesh, Fariba; Sobhanardekani, Mohammad; Zabihi, Somayeh; Behniafard, Nasim

2016-12-01

Proliferative myositis (PM) is a rare inflammatory disease. Most commonly, the lesion occurs in the extremities. Regarding its fast growth and bizarre shape of the cellular components this entity commonly misdiagnosed and the patients undergo improper therapeutic approaches. In other words, it is often misdiagnosed as sarcoma. The diagnosis can only be made by the microscopic examination, so biopsy is mandatory. Here the authors report a patient with PM who was initially misdiagnosed as pleomorphic sarcoma of the lower extremity and explain this rare entity. Proliferative myositis should be taken into account if a fast growing, intramuscular mass occurs in the extremities.

Whole transcriptome analysis of the fasting and fed Burmese python heart: insights into extreme physiological cardiac adaptation.

PubMed

Wall, Christopher E; Cozza, Steven; Riquelme, Cecilia A; McCombie, W Richard; Heimiller, Joseph K; Marr, Thomas G; Leinwand, Leslie A

2011-01-01

The infrequently feeding Burmese python (Python molurus) experiences significant and rapid postprandial cardiac hypertrophy followed by regression as digestion is completed. To begin to explore the molecular mechanisms of this response, we have sequenced and assembled the fasted and postfed Burmese python heart transcriptomes with Illumina technology using the chicken (Gallus gallus) genome as a reference. In addition, we have used RNA-seq analysis to identify differences in the expression of biological processes and signaling pathways between fasted, 1 day postfed (DPF), and 3 DPF hearts. Out of a combined transcriptome of ∼2,800 mRNAs, 464 genes were differentially expressed. Genes showing differential expression at 1 DPF compared with fasted were enriched for biological processes involved in metabolism and energetics, while genes showing differential expression at 3 DPF compared with fasted were enriched for processes involved in biogenesis, structural remodeling, and organization. Moreover, we present evidence for the activation of physiological and not pathological signaling pathways in this rapid, novel model of cardiac growth in pythons. Together, our data provide the first comprehensive gene expression profile for a reptile heart.

Advanced Power Sources for Space Missions

DTIC Science & Technology

1989-01-01

Range indicate that extremely high power levels hav- ing fast time-ramping capabilities must be provided during the tests. Only highly efficient prime...system efficiency results from advantages in thermal storage versus battery storage and from the increased conversion efficiency of a solar-dynamic... thermal manage- ment, power flow, and voltage levels, and may be in the same power range already experienced in the very- high -power radar and fusion

Observation of extremely strong shock waves in solids launched by petawatt laser heating

DOE PAGES

Lancaster, K. L.; Robinson, A. P. L.; Pasley, J.; ...

2017-08-25

Understanding hydrodynamic phenomena driven by fast electron heating is important for a range of applications including fast electron collimation schemes for fast ignition and the production and study of hot, dense matter. In this work, detailed numerical simulations modelling the heating, hydrodynamic evolution, and extreme ultra-violet (XUV) emission in combination with experimental XUV images indicate shock waves of exceptional strength (200 Mbar) launched due to rapid heating of materials via a petawatt laser. In conclusion, we discuss in detail the production of synthetic XUV images and how they assist us in interpreting experimental XUV images captured at 256 eV usingmore » a multi-layer spherical mirror.« less

Extremely Fast Numerical Integration of Ocean Surface Wave Dynamics

DTIC Science & Technology

2007-09-30

sub-processor must be added as shown in the blue box of Fig. 1. We first consider the Kadomtsev - Petviashvili (KP) equation ηt + coηx +αηηx + βη ...analytic integration of the so-called “soliton equations ,” I have discovered how the GFT can be used to solved higher order equations for which study...analytical study and extremely fast numerical integration of the extended nonlinear Schroedinger equation for fully three dimensional wave motion

Lower Extremity Muscle Activity During a Women’s Overhand Lacrosse Shot

PubMed Central

Millard, Brianna M.; Mercer, John A.

2014-01-01

The purpose of this study was to describe lower extremity muscle activity during the lacrosse shot. Participants (n=5 females, age 22±2 years, body height 162.6±15.2 cm, body mass 63.7±23.6 kg) were free from injury and had at least one year of lacrosse experience. The lead leg was instrumented with electromyography (EMG) leads to measure muscle activity of the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), and medial gastrocnemius (GA). Participants completed five trials of a warm-up speed shot (Slow) and a game speed shot (Fast). Video analysis was used to identify the discrete events defining specific movement phases. Full-wave rectified data were averaged per muscle per phase (Crank Back Minor, Crank Back Major, Stick Acceleration, Stick Deceleration). Average EMG per muscle was analyzed using a 4 (Phase) × 2 (Speed) ANOVA. BF was greater during Fast vs. Slow for all phases (p<0.05), while TA was not influenced by either Phase or Speed (p>0.05). RF and GA were each influenced by the interaction of Phase and Speed (p<0.05) with GA being greater during Fast vs. Slow shots during all phases and RF greater during Crank Back Minor and Major as well as Stick Deceleration (p<0.05) but only tended to be greater during Stick Acceleration (p=0.076) for Fast vs. Slow. The greater muscle activity (BF, RF, GA) during Fast vs. Slow shots may have been related to a faster approach speed and/or need to create a stiff lower extremity to allow for faster upper extremity movements. PMID:25114727

CASTOR: Widely Distributed Scalable Infospaces

DTIC Science & Technology

2008-11-01

1  i Progress against Planned Objectives Enable nimble apps that react fast as...generation of scalable, reliable, ultra- fast event notification in Linux data centers. • Maelstrom, a spin-off from Ricochet, offers a powerful new option...out potential enhancements to WS-EVENTING and WS-NOTIFICATION based on our work. Potential impact for the warflighter. QSM achieves extremely fast

Solid-state reversible quadratic nonlinear optical molecular switch with an exceptionally large contrast.

PubMed

Sun, Zhihua; Luo, Junhua; Zhang, Shuquan; Ji, Chengmin; Zhou, Lei; Li, Shenhui; Deng, Feng; Hong, Maochun

2013-08-14

Exceptional nonlinear optical (NLO) switching behavior, including an extremely large contrast (on/off) of ∼35 and high NLO coefficients, is displayed by a solid-state reversible quadratic NLO switch. The favorable results, induced by very fast molecular motion and anionic ordering, provides impetus for the design of a novel second-harmonic-generation switch involving molecular motion. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Small Sample Reactivity Measurements in the RRR/SEG Facility: Reanalysis using TRIPOLI-4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hummel, Andrew; Palmiotti, Guiseppe

2016-08-01

This work involved reanalyzing the RRR/SEG integral experiments performed at the Rossendorf facility in Germany throughout the 1970s and 80s. These small sample reactivity worth measurements were carried out using the pile oscillator technique for many different fission products, structural materials, and standards. The coupled fast-thermal system was designed such that the measurements would provide insight into elemental data, specifically the competing effects between neutron capture and scatter. Comparing the measured to calculated reactivity values can then provide adjustment criteria to ultimately improve nuclear data for fast reactor designs. Due to the extremely small reactivity effects measured (typically less thanmore » 1 pcm) and the specific heterogeneity of the core, the tool chosen for this analysis was TRIPOLI-4. This code allows for high fidelity 3-dimensional geometric modeling, and the most recent, unreleased version, is capable of exact perturbation theory.« less

The Functional Arm Scale for Throwers (FAST)-Part I: The Design and Development of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes.

PubMed

Sauers, Eric L; Bay, R Curtis; Snyder Valier, Alison R; Ellery, Traci; Huxel Bliven, Kellie C

2017-03-01

Upper extremity (UE) region-specific, patient-reported outcome (PRO) scales assess injuries to the UE but do not account for the demands of overhead throwing athletes or measure patient-oriented domains of health-related quality of life (HRQOL). To develop the Functional Arm Scale for Throwers (FAST), a UE region-specific and population-specific PRO scale that assesses multiple domains of disablement in throwing athletes with UE injuries. In stage I, a beta version of the scale was developed for subsequent factor identification, final item reduction, and construct validity analysis during stage II. Descriptive laboratory study. Three-stage scale development was utilized: Stage I (item generation and initial item reduction) and stage II (factor analysis, final item reduction, and construct validity) are reported herein, and stage III (establishment of measurement properties [reliability and validity]) will be reported in a companion paper. In stage I, a beta version was developed, incorporating National Center for Medical Rehabilitation Research disablement domains and ensuring a blend of sport-related and non-sport-related items. An expert panel and focus group assessed importance and interpretability of each item. During stage II, the FAST was reduced, preserving variance characteristics and factor structure of the beta version and construct validity of the final FAST scale. During stage I, a 54-item beta version and a separate 9-item pitcher module were developed. During stage II, a 22-item FAST and 9-item pitcher module were finalized. The factor solution for FAST scale items included pain (n = 6), throwing (n = 10), activities of daily living (n = 5), psychological impact (n = 4), and advancement (n = 3). The 6-item pain subscale crossed factors. The remaining subscales and pitcher module are distinctive, correlated, and internally consistent and may be interpreted individually or combined. This article describes the development of the FAST, which assesses clinical outcomes and HRQOL of throwing athletes after UE injury. The FAST encompasses multiple domains of disability and demonstrates excellent construct validity. The FAST provides a single UE region-specific and population-specific PRO scale for high-demand throwers to facilitate measurement of impact of UE injuries on HRQOL and clinical outcomes while quantifying recovery for comparative effectiveness studies.

Development of Pulsar Detection Methods for a Galactic Center Search

NASA Astrophysics Data System (ADS)

Thornton, Stephen; Wharton, Robert; Cordes, James; Chatterjee, Shami

2018-01-01

Finding pulsars within the inner parsec of the galactic center would be incredibly beneficial: for pulsars sufficiently close to Sagittarius A*, extremely precise tests of general relativity in the strong field regime could be performed through measurement of post-Keplerian parameters. Binary pulsar systems with sufficiently short orbital periods could provide the same laboratories with which to test existing theories. Fast and efficient methods are needed to parse large sets of time-domain data from different telescopes to search for periodicity in signals and differentiate radio frequency interference (RFI) from pulsar signals. Here we demonstrate several techniques to reduce red noise (low-frequency interference), generate signals from pulsars in binary orbits, and create plots that allow for fast detection of both RFI and pulsars.

Product screening of fast reactions in IR-laser-heated liquid water filaments in a vacuum by mass spectrometry.

PubMed

Charvat, A; Stasicki, B; Abel, B

2006-03-09

In the present article a novel approach for rapid product screening of fast reactions in IR-laser-heated liquid microbeams in a vacuum is highlighted. From absorbed energies, a shock wave analysis, high-speed laser stroboscopy, and thermodynamic data of high-temperature water the enthalpy, temperature, density, pressure, and the reaction time window for the hot water filament could be characterized. The experimental conditions (30 kbar, 1750 K, density approximately 1 g/cm3) present during the lifetime of the filament (20-30 ns) were extreme and provided a unique environment for high-temperature water chemistry. For the probe of the reaction products liquid beam desorption mass spectrometry was employed. A decisive feature of the technique is that ionic species, as well as neutral products and intermediates may be detected (neutrals as protonated aggregates) via time-of-flight mass spectrometry without any additional ionization laser. After the explosive disintegration of the superheated beam, high-temperature water reactions are efficiently quenched via expansion and evaporative cooling. For first exploratory experiments for chemistry in ultrahigh-temperature, -pressure and -density water, we have chosen resorcinol as a benchmark system, simple enough and well studied in high-temperature water environments much below 1000 K. Contrary to oxidation reactions usually present under less extreme and dense supercritical conditions, we have observed hydration and little H-atom abstraction during the narrow time window of the experiment. Small amounts of radicals but no ionic intermediates other than simple proton adducts were detected. The experimental findings are discussed in terms of the energetic and dense environment and the small time window for reaction, and they provide firm evidence for additional thermal reaction channels in extreme molecular environments.

XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Mid-year report FY17 Q2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreland, Kenneth D.; Pugmire, David; Rogers, David

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressingmore » four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.« less

XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Year-end report FY17.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreland, Kenneth D.; Pugmire, David; Rogers, David

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressingmore » four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.« less

XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem. Mid-year report FY16 Q2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreland, Kenneth D.; Sewell, Christopher; Childs, Hank

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressingmore » four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.« less

XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Year-end report FY15 Q4.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreland, Kenneth D.; Sewell, Christopher; Childs, Hank

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressingmore » four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.« less

Capabilities of a Global 3D MHD Model for Monitoring Extremely Fast CMEs

NASA Astrophysics Data System (ADS)

Wu, C. C.; Plunkett, S. P.; Liou, K.; Socker, D. G.; Wu, S. T.; Wang, Y. M.

2015-12-01

Since the start of the space era, spacecraft have recorded many extremely fast coronal mass ejections (CMEs) which have resulted in severe geomagnetic storms. Accurate and timely forecasting of the space weather effects of these events is important for protecting expensive space assets and astronauts and avoiding communications interruptions. Here, we will introduce a newly developed global, three-dimensional (3D) magnetohydrodynamic (MHD) model (G3DMHD). The model takes the solar magnetic field maps at 2.5 solar radii (Rs) and intepolates the solar wind plasma and field out to 18 Rs using the algorithm of Wang and Sheeley (1990, JGR). The output is used as the inner boundary condition for a 3D MHD model. The G3DMHD model is capable of simulating (i) extremely fast CME events with propagation speeds faster than 2500 km/s; and (ii) multiple CME events in sequence or simultaneously. We will demonstrate the simulation results (and comparison with in-situ observation) for the fastest CME in record on 23 July 2012, the shortest transit time in March 1976, and the well-known historic Carrington 1859 event.

Army Training Study: Training Effectiveness Analysis (TEA) Summary. Volume 3. REDEYE Weapons System.

DTIC Science & Technology

1978-08-08

gunners provide Air Defense. At night, when the unit moves, the gunners must go also. This tires the gunner extremely fast , which makes him less astute in...Army AIT is the Lanier " Slow Comet," which has a 75" wing span and is 43" long. The craft provides a profile which is representative of a small prop...that what you are doing in the Ariv is worthwhile or not? a. I am certain it is vworthwhile. b. I think it is worthwhile. c. I don’t t) hink it is

Differential staining of bacteria: acid fast stain.

PubMed

Reynolds, Jackie; Moyes, Rita B; Breakwell, Donald P

2009-11-01

Acid-fastness is an uncommon characteristic shared by the genera Mycobacterium (Section 10A) and Nocardia. Because of this feature, this stain is extremely helpful in identification of these bacteria. Although Gram positive, acid-fast bacteria do not take the crystal violet into the wall well, appearing very light purple rather than the deep purple of normal Gram-positive bacteria. (c) 2009 by John Wiley & Sons, Inc.

Fast Coherent Differential Imaging for Exoplanet Imaging

NASA Astrophysics Data System (ADS)

Gerard, Benjamin; Marois, Christian; Galicher, Raphael; Veran, Jean-Pierre; Macintosh, B.; Guyon, O.; Lozi, J.; Pathak, P.; Sahoo, A.

2018-06-01

Direct detection and detailed characterization of exoplanets using extreme adaptive optics (ExAO) is a key science goal of future extremely large telescopes and space observatories. However, quasi-static wavefront errors will limit the sensitivity of this endeavor. Additional limitations for ground-based telescopes arise from residual AO-corrected atmospheric wavefront errors, generating short-lived aberrations that will average into a halo over a long exposure, also limiting the sensitivity of exoplanet detection. We develop the framework for a solution to both of these problems using the self-coherent camera (SCC), to be applied to ground-based telescopes, called Fast Atmospheric SCC Technique (FAST). Simulations show that for typical ExAO targets the FAST approach can reach ~100 times better in raw contrast than what is currently achieved with ExAO instruments if we extrapolate for an hour of observing time, illustrating that the sensitivity improvement from this method could play an essential role in the future ground-based detection and characterization of lower mass/colder exoplanets.

Left–right coordination from simple to extreme conditions during split‐belt locomotion in the chronic spinal adult cat

PubMed Central

Desrochers, Étienne; Thibaudier, Yann; Hurteau, Marie‐France; Dambreville, Charline

2016-01-01

Key points Coordination between the left and right sides is essential for dynamic stability during locomotion.The immature or neonatal mammalian spinal cord can adjust to differences in speed between the left and right sides during split‐belt locomotion by taking more steps on the fast side.We show that the adult mammalian spinal cord can also adjust its output so that the fast side can take more steps.During split‐belt locomotion, only certain parts of the cycle are modified to adjust left–right coordination, primarily those associated with swing onset.When the fast limb takes more steps than the slow limb, strong left–right interactions persist.Therefore, the adult mammalian spinal cord has a remarkable adaptive capacity for left–right coordination, from simple to extreme conditions. Abstract Although left–right coordination is essential for locomotion, its control is poorly understood, particularly in adult mammals. To investigate the spinal control of left–right coordination, a spinal transection was performed in six adult cats that were then trained to recover hindlimb locomotion. Spinal cats performed tied‐belt locomotion from 0.1 to 1.0 m s−1 and split‐belt locomotion with low to high (1:1.25–10) slow/fast speed ratios. With the left hindlimb stepping at 0.1 m s−1 and the right hindlimb stepping from 0.2 to 1.0 m s−1, 1:1, 1:2, 1:3, 1:4 and 1:5 left–right step relationships could appear. The appearance of 1:2+ relationships was not linearly dependent on the difference in speed between the slow and fast belts. The last step taken by the fast hindlimb displayed longer cycle, stance and swing durations and increased extensor activity, as the slow limb transitioned to swing. During split‐belt locomotion with 1:1, 1:2 and 1:3 relationships, the timing of stance onset of the fast limb relative to the slow limb and placement of both limbs at contact were invariant with increasing slow/fast speed ratios. In contrast, the timing of stance onset of the slow limb relative to the fast limb and the placement of both limbs at swing onset were modulated with slow/fast speed ratios. Thus, left–right coordination is adjusted by modifying specific parts of the cycle. Results highlight the remarkable adaptive capacity of the adult mammalian spinal cord, providing insight into spinal mechanisms and sensory signals regulating left–right coordination. PMID:27426732

Quantitative Imaging in Laboratory: Fast Kinetics and Fluorescence Quenching

ERIC Educational Resources Information Center

Cumberbatch, Tanya; Hanley, Quentin S.

2007-01-01

The process of quantitative imaging, which is very commonly used in laboratory, is shown to be very useful for studying the fast kinetics and fluorescence quenching of many experiments. The imaging technique is extremely cheap and hence can be used in many absorption and luminescence experiments.

BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".

PubMed

Chen, Deliang; Savidge, Tor

2015-08-28

Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field-dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis. Copyright © 2015, American Association for the Advancement of Science.

Comparative Analyses of Two Extremely Fast CMEs Induced Shocks using A H3DMHD Model

NASA Astrophysics Data System (ADS)

Wu, S. T.; Wu, C. C.; Liou, K.; Dryer, Ph D., M.; Plunkett, S. P.

2015-12-01

During the last two decades, spacecraft recorded several extremely fast Coronal Mass Ejections (CMEs) which have resulted in severe geomagnetic storms. Here, we will report results from a comparative study of two extremely fast CME events: one on 29 October 2003 (Halloween 2003 epoch) and the other on 23 July 2012. Both shock events reached 1 AU within ~20 hours. We employed a global three-dimensional (3D) magnetohydrodynamics (MHD) simulation model (H3DMHD, Wu et al. 2007, JGR) to study these two events and compared the results with observations (e.g., 1 AU in-situ data, and coronal images from SOHO/LASCO or STEREO/ SECCHI). It was found that: (i) The peak temperature, velocity, and density of the solar wind for the shock/ICME event are 2 x 107 K, 2500 km s-1, and 35 cm-3, respectively. (ii) The peaks of magnetic field (B) are ~60 and 110 nT for the event on 29 October 2003 and 23 July 2012, respectively. Solar wind densities behind the shocks are extremely low which are due to rarefaction of the interplanetary shocks' propagation. We will discuss this issue in the presentation. Simulations are vastly improved and forecasting arrival times should be done as noted in real time by Zhou and Dryer (Space Weather Quarterly, 2014) review, but CME and B therein is still a major challenge for storm prediction.

FAST TRACK COMMUNICATION: Freezing and extreme-value statistics in a random energy model with logarithmically correlated potential

NASA Astrophysics Data System (ADS)

Fyodorov, Yan V.; Bouchaud, Jean-Philippe

2008-09-01

We investigate some implications of the freezing scenario proposed by Carpentier and Le Doussal (CLD) for a random energy model (REM) with logarithmically correlated random potential. We introduce a particular (circular) variant of the model, and show that the integer moments of the partition function in the high-temperature phase are given by the well-known Dyson Coulomb gas integrals. The CLD freezing scenario allows one to use those moments for extracting the distribution of the free energy in both high- and low-temperature phases. In particular, it yields the full distribution of the minimal value in the potential sequence. This provides an explicit new class of extreme-value statistics for strongly correlated variables, manifestly different from the standard Gumbel class.

Spectroscopic Measurements of the Ion Velocity Distribution at the Base of the Fast Solar Wind

NASA Astrophysics Data System (ADS)

Jeffrey, Natasha L. S.; Hahn, Michael; Savin, Daniel W.; Fletcher, Lyndsay

2018-03-01

In situ measurements of the fast solar wind reveal non-thermal distributions of electrons, protons, and minor ions extending from 0.3 au to the heliopause. The physical mechanisms responsible for these non-thermal properties and the location where these properties originate remain open questions. Here, we present spectroscopic evidence, from extreme ultraviolet spectroscopy, that the velocity distribution functions (VDFs) of minor ions are already non-Gaussian at the base of the fast solar wind in a coronal hole, at altitudes of <1.1 R ⊙. Analysis of Fe, Si, and Mg spectral lines reveals a peaked line-shape core and broad wings that can be characterized by a kappa VDF. A kappa distribution fit gives very small kappa indices off-limb of κ ≈ 1.9–2.5, indicating either (a) ion populations far from thermal equilibrium, (b) fluid motions such as non-Gaussian turbulent fluctuations or non-uniform wave motions, or (c) some combination of both. These observations provide important empirical constraints for the source region of the fast solar wind and for the theoretical models of the different acceleration, heating, and energy deposition processes therein. To the best of our knowledge, this is the first time that the ion VDF in the fast solar wind has been probed so close to its source region. The findings are also a timely precursor to the upcoming 2018 launch of the Parker Solar Probe, which will provide the closest in situ measurements of the solar wind at approximately 0.04 au (8.5 solar radii).

Fasting - the ultimate diet?

PubMed

Johnstone, A M

2007-05-01

Adult humans often undertake acute fasts for cosmetic, religious or medical reasons. For example, an estimated 14% of US adults have reported using fasting as a means to control body weight and this approach has long been advocated as an intermittent treatment for gross refractory obesity. There are unique historical data sets on extreme forms of food restriction that give insight into the consequences of starvation or semi-starvation in previously healthy, but usually non-obese subjects. These include documented medical reports on victims of hunger strike, famine and prisoners of war. Such data provide a detailed account on how the body adapts to prolonged starvation. It has previously been shown that fasting for the biblical period of 40 days and 40 nights is well within the overall physiological capabilities of a healthy adult. However, the specific effects on the human body and mind are less clearly documented, either in the short term (hours) or in the longer term (days). This review asks the following three questions, pertinent to any weight-loss therapy, (i) how effective is the regime in achieving weight loss, (ii) what impact does it have on psychology? and finally, (iii) does it work long-term?

Feasibility of the Precise Energy Calibration for Fast Neutron Spectrometers

NASA Astrophysics Data System (ADS)

Gaganov, V. V.; Usenko, P. L.; Kryzhanovskaja, M. A.

2017-12-01

Computational studies aimed at improving the accuracy of measurements performed using neutron generators with a tritium target were performed. A measurement design yielding an extremely narrow peak in the energy spectrum of DT neutrons was found. The presence of such a peak establishes the conditions for precise energy calibration of fast-neutron spectrometers.

Prediction of Air Pollutants Concentration Based on an Extreme Learning Machine: The Case of Hong Kong

PubMed Central

Zhang, Jiangshe; Ding, Weifu

2017-01-01

With the development of the economy and society all over the world, most metropolitan cities are experiencing elevated concentrations of ground-level air pollutants. It is urgent to predict and evaluate the concentration of air pollutants for some local environmental or health agencies. Feed-forward artificial neural networks have been widely used in the prediction of air pollutants concentration. However, there are some drawbacks, such as the low convergence rate and the local minimum. The extreme learning machine for single hidden layer feed-forward neural networks tends to provide good generalization performance at an extremely fast learning speed. The major sources of air pollutants in Hong Kong are mobile, stationary, and from trans-boundary sources. We propose predicting the concentration of air pollutants by the use of trained extreme learning machines based on the data obtained from eight air quality parameters in two monitoring stations, including Sham Shui Po and Tap Mun in Hong Kong for six years. The experimental results show that our proposed algorithm performs better on the Hong Kong data both quantitatively and qualitatively. Particularly, our algorithm shows better predictive ability, with R2 increased and root mean square error values decreased respectively. PMID:28125034

Purposeful Variable Selection and Stratification to Impute Missing FAST Data in Trauma Research

PubMed Central

Fuchs, Paul A.; del Junco, Deborah J.; Fox, Erin E.; Holcomb, John B.; Rahbar, Mohammad H.; Wade, Charles A.; Alarcon, Louis H.; Brasel, Karen J.; Bulger, Eileen M.; Cohen, Mitchell J.; Myers, John G.; Muskat, Peter; Phelan, Herb A.; Schreiber, Martin A.; Cotton, Bryan A.

2013-01-01

Background The Focused Assessment with Sonography for Trauma (FAST) exam is an important variable in many retrospective trauma studies. The purpose of this study was to devise an imputation method to overcome missing data for the FAST exam. Due to variability in patients’ injuries and trauma care, these data are unlikely to be missing completely at random (MCAR), raising concern for validity when analyses exclude patients with missing values. Methods Imputation was conducted under a less restrictive, more plausible missing at random (MAR) assumption. Patients with missing FAST exams had available data on alternate, clinically relevant elements that were strongly associated with FAST results in complete cases, especially when considered jointly. Subjects with missing data (32.7%) were divided into eight mutually exclusive groups based on selected variables that both described the injury and were associated with missing FAST values. Additional variables were selected within each group to classify missing FAST values as positive or negative, and correct FAST exam classification based on these variables was determined for patients with non-missing FAST values. Results Severe head/neck injury (odds ratio, OR=2.04), severe extremity injury (OR=4.03), severe abdominal injury (OR=1.94), no injury (OR=1.94), other abdominal injury (OR=0.47), other head/neck injury (OR=0.57) and other extremity injury (OR=0.45) groups had significant ORs for missing data; the other group odds ratio was not significant (OR=0.84). All 407 missing FAST values were imputed, with 109 classified as positive. Correct classification of non-missing FAST results using the alternate variables was 87.2%. Conclusions Purposeful imputation for missing FAST exams based on interactions among selected variables assessed by simple stratification may be a useful adjunct to sensitivity analysis in the evaluation of imputation strategies under different missing data mechanisms. This approach has the potential for widespread application in clinical and translational research and validation is warranted. Level of Evidence Level II Prognostic or Epidemiological PMID:23778515

Picosecond amorphization of SiO2 stishovite under tension.

PubMed

Misawa, Masaaki; Ryuo, Emina; Yoshida, Kimiko; Kalia, Rajiv K; Nakano, Aiichiro; Nishiyama, Norimasa; Shimojo, Fuyuki; Vashishta, Priya; Wakai, Fumihiro

2017-05-01

It is extremely difficult to realize two conflicting properties-high hardness and toughness-in one material. Nano-polycrystalline stishovite, recently synthesized from Earth-abundant silica glass, proved to be a super-hard, ultra-tough material, which could provide sustainable supply of high-performance ceramics. Our quantum molecular dynamics simulations show that stishovite amorphizes rapidly on the order of picosecond under tension in front of a crack tip. We find a displacive amorphization mechanism that only involves short-distance collective motions of atoms, thereby facilitating the rapid transformation. The two-step amorphization pathway involves an intermediate state akin to experimentally suggested "high-density glass polymorphs" before eventually transforming to normal glass. The rapid amorphization can catch up with, screen, and self-heal a fast-moving crack. This new concept of fast amorphization toughening likely operates in other pressure-synthesized hard solids.

Comparison between extreme learning machine and wavelet neural networks in data classification

NASA Astrophysics Data System (ADS)

Yahia, Siwar; Said, Salwa; Jemai, Olfa; Zaied, Mourad; Ben Amar, Chokri

2017-03-01

Extreme learning Machine is a well known learning algorithm in the field of machine learning. It's about a feed forward neural network with a single-hidden layer. It is an extremely fast learning algorithm with good generalization performance. In this paper, we aim to compare the Extreme learning Machine with wavelet neural networks, which is a very used algorithm. We have used six benchmark data sets to evaluate each technique. These datasets Including Wisconsin Breast Cancer, Glass Identification, Ionosphere, Pima Indians Diabetes, Wine Recognition and Iris Plant. Experimental results have shown that both extreme learning machine and wavelet neural networks have reached good results.

Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels

PubMed Central

Sheets, Patrick L; Jarecki, Brian W; Cummins, Theodore R

2011-01-01

BACKGROUND AND PURPOSE The primary use of local anaesthetics is to prevent or relieve pain by reversibly preventing action potential propagation through the inhibition of voltage-gated sodium channels. The tetrodotoxin-sensitive voltage-gated sodium channel subtype Nav1.7, abundantly expressed in pain-sensing neurons, plays a crucial role in perception and transmission of painful stimuli and in inherited chronic pain syndromes. Understanding the interaction of lidocaine with Nav1.7 channels could provide valuable insight into the drug's action in alleviating pain in distinct patient populations. The aim of this study was to determine how lidocaine interacts with multiple inactivated conformations of Nav1.7 channels. EXPERIMENTAL APPROACH We investigated the interactions of lidocaine with wild-type Nav1.7 channels and a paroxysmal extreme pain disorder mutation (I1461T) that destabilizes fast inactivation. Whole cell patch clamp recordings were used to examine the activity of channels expressed in human embryonic kidney 293 cells. KEY RESULTS Depolarizing pulses that increased slow inactivation of Nav1.7 channels also reduced lidocaine inhibition. Lidocaine enhanced recovery of Nav1.7 channels from prolonged depolarizing pulses by decreasing slow inactivation. A paroxysmal extreme pain disorder mutation that destabilizes fast inactivation of Nav1.7 channels decreased lidocaine inhibition. CONCLUSIONS AND IMPLICATIONS Lidocaine decreased the transition of Nav1.7 channels to the slow inactivated state. The fast inactivation gate (domain III–IV linker) is important for potentiating the interaction of lidocaine with the Nav1.7 channel. PMID:21232038

Extreme Sparse Multinomial Logistic Regression: A Fast and Robust Framework for Hyperspectral Image Classification

NASA Astrophysics Data System (ADS)

Cao, Faxian; Yang, Zhijing; Ren, Jinchang; Ling, Wing-Kuen; Zhao, Huimin; Marshall, Stephen

2017-12-01

Although the sparse multinomial logistic regression (SMLR) has provided a useful tool for sparse classification, it suffers from inefficacy in dealing with high dimensional features and manually set initial regressor values. This has significantly constrained its applications for hyperspectral image (HSI) classification. In order to tackle these two drawbacks, an extreme sparse multinomial logistic regression (ESMLR) is proposed for effective classification of HSI. First, the HSI dataset is projected to a new feature space with randomly generated weight and bias. Second, an optimization model is established by the Lagrange multiplier method and the dual principle to automatically determine a good initial regressor for SMLR via minimizing the training error and the regressor value. Furthermore, the extended multi-attribute profiles (EMAPs) are utilized for extracting both the spectral and spatial features. A combinational linear multiple features learning (MFL) method is proposed to further enhance the features extracted by ESMLR and EMAPs. Finally, the logistic regression via the variable splitting and the augmented Lagrangian (LORSAL) is adopted in the proposed framework for reducing the computational time. Experiments are conducted on two well-known HSI datasets, namely the Indian Pines dataset and the Pavia University dataset, which have shown the fast and robust performance of the proposed ESMLR framework.

Ground and Flight Testing for Aircraft Guidance and Control,

DTIC Science & Technology

1984-12-01

almost rigid structure (Figure 3). It is equipped with control surfa- - S ces (inner flaps, outer flaps, elevator) which are driven by fast acting...extremely fast -response actuators com- bined with a full fly-by-wire/light system is envisaged. The technology for doing this is not yet available today...6.6 late S Standard deviation 23.7 (77.8) 6.5 12.0 *Maximum error 51.5 (169) high 12.9 fast 29.0 late *The values of these errors were judged by the

A New Approximate Chimera Donor Cell Search Algorithm

NASA Technical Reports Server (NTRS)

Holst, Terry L.; Nixon, David (Technical Monitor)

1998-01-01

The objectives of this study were to develop chimera-based full potential methodology which is compatible with overflow (Euler/Navier-Stokes) chimera flow solver and to develop a fast donor cell search algorithm that is compatible with the chimera full potential approach. Results of this work included presenting a new donor cell search algorithm suitable for use with a chimera-based full potential solver. This algorithm was found to be extremely fast and simple producing donor cells as fast as 60,000 per second.

When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches

PubMed Central

Muñoz, Victor; Cerminara, Michele

2016-01-01

Protein folding research stalled for decades because conventional experiments indicated that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay between dynamics and energetics resulting in myriad microscopic pathways. Ultrafast kinetic methods turned the field upside down by providing the means to probe fundamental aspects of folding, test theoretical predictions and benchmark simulations. Accordingly, experimentalists could measure the timescales for all relevant folding motions, determine the folding speed limit and confirm that folding barriers are entropic bottlenecks. Moreover, a catalogue of proteins that fold extremely fast (microseconds) could be identified. Such fast-folding proteins cross shallow free energy barriers or fold downhill, and thus unfold with minimal co-operativity (gradually). A new generation of thermodynamic methods has exploited this property to map folding landscapes, interaction networks and mechanisms at nearly atomic resolution. In parallel, modern molecular dynamics simulations have finally reached the timescales required to watch fast-folding proteins fold and unfold in silico. All of these findings have buttressed the fundamentals of protein folding predicted by theory, and are now offering the first glimpses at the underlying mechanisms. Fast folding appears to also have functional implications as recent results connect downhill folding with intrinsically disordered proteins, their complex binding modes and ability to moonlight. These connections suggest that the coupling between downhill (un)folding and binding enables such protein domains to operate analogically as conformational rheostats. PMID:27574021

Quasi-periodic Counter-propagating Fast Magnetosonic Wave Trains from Neighboring Flares: SDO/AIA Observations and 3D MHD Modeling

NASA Astrophysics Data System (ADS)

Ofman, Leon; Liu, Wei

2018-06-01

Since their discovery by the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA) in the extreme ultraviolet, rapid (phase speeds of ∼1000 km s‑1), quasi-periodic, fast-mode propagating (QFP) wave trains have been observed accompanying many solar flares. They typically propagate in funnel-like structures associated with the expanding magnetic field topology of the active regions (ARs). The waves provide information on the associated flare pulsations and the magnetic structure through coronal seismology (CS). The reported waves usually originate from a single localized source associated with the flare. Here we report the first detection of counter-propagating QFPs associated with two neighboring flares on 2013 May 22, apparently connected by large-scale, trans-equatorial coronal loops. We present the first results of a 3D MHD model of counter-propagating QFPs in an idealized bipolar AR. We investigate the excitation, propagation, nonlinearity, and interaction of the counter-propagating waves for a range of key model parameters, such as the properties of the sources and the background magnetic structure. In addition to QFPs, we also find evidence of trapped fast- (kink) and slow-mode waves associated with the event. We apply CS to determine the magnetic field strength in an oscillating loop during the event. Our model results are in qualitative agreement with the AIA-observed counter-propagating waves and used to identify the various MHD wave modes associated with the observed event, providing insights into their linear and nonlinear interactions. Our observations provide the first direct evidence of counter-propagating fast magnetosonic waves that can potentially lead to turbulent cascade and carry significant energy flux for coronal heating in low-corona magnetic structures.

Effects of fast walking on tibiofemoral bone water content in middle-aged adults.

PubMed

Ho, Kai-Yu; Standerfer, Alexa; Ngo, Suzenna; Daun, Karen; Lee, Szu-Ping

2016-08-01

Although it is believed that genu varum increases loading on the medial knee during locomotion, the acute effect of increased loading on bone stress has not been determined. This study aimed to examine the effects of locomotion and lower extremity alignment on bone water content in middle-aged adults without knee osteoarthritis. Five males and 5 females participated. Lower extremity alignment was defined as the angle between the midpoint of the anterior mid-thigh and the midpoint of the patellar tendon using the center of the patella as the fulcrum. A chemical-shift-encoded water-fat magnetic resonance imaging protocol was used to assess bone water content before and after a 30-minute fast walking session. Bone stress response was determined by quantifying water content within the weight-bearing regions of the medial and lateral compartments of the tibiofemoral joint. Paired t-tests were used to compare bone water content before and after fast walking. Pearson correlation coefficients were used to determine the associations between lower extremity alignment and changes in water content post-walking. The paired t-tests revealed no changes in water content after fast walking within medial and lateral femur/tibia (P>0.05). Pearson correlation analyses revealed a significant moderate correlation between increased bone water content of the medial femur and increased varus alignment (R=0.688, P=0.028). Although there was no significant change in bone water content following locomotion, knee varus was associated with signs of bone stress in the medial femur. Copyright © 2016 Elsevier Ltd. All rights reserved.

Optics Communications: Special issue on Polymer Photonics and Its Applications

NASA Astrophysics Data System (ADS)

Zhang, Ziyang; Pitwon, Richard C. A.; Feng, Jing

2016-03-01

In the last decade polymer photonics has witnessed a tremendous boost in research efforts and practical applications. Polymer materials can be engineered to exhibit unique optical and electrical properties. Extremely transparent and reliable passive optical polymers have been made commercially available and paved the ground for the development of various waveguide components. Advancement in the research activities regarding the synthesis of active polymers has enabled devices such as ultra-fast electro-optic modulators, efficient white light emitting diodes, broadband solar cells, flexible displays, and so on. The fabrication technology is not only fast and cost-effective, but also provides flexibility and broad compatibility with other semiconductor processing technologies. Reports show that polymers have been integrated in photonic platforms such as silicon-on-insulator (SOI), III-V semiconductors, and silica PLCs, and vice versa, photonic components made from a multitude of materials have been integrated, in a heterogeneous/hybrid manner, in polymer photonic platforms.

Picosecond amorphization of SiO2 stishovite under tension

PubMed Central

Misawa, Masaaki; Ryuo, Emina; Yoshida, Kimiko; Kalia, Rajiv K.; Nakano, Aiichiro; Nishiyama, Norimasa; Shimojo, Fuyuki; Vashishta, Priya; Wakai, Fumihiro

2017-01-01

It is extremely difficult to realize two conflicting properties—high hardness and toughness—in one material. Nano-polycrystalline stishovite, recently synthesized from Earth-abundant silica glass, proved to be a super-hard, ultra-tough material, which could provide sustainable supply of high-performance ceramics. Our quantum molecular dynamics simulations show that stishovite amorphizes rapidly on the order of picosecond under tension in front of a crack tip. We find a displacive amorphization mechanism that only involves short-distance collective motions of atoms, thereby facilitating the rapid transformation. The two-step amorphization pathway involves an intermediate state akin to experimentally suggested “high-density glass polymorphs” before eventually transforming to normal glass. The rapid amorphization can catch up with, screen, and self-heal a fast-moving crack. This new concept of fast amorphization toughening likely operates in other pressure-synthesized hard solids. PMID:28508056

An Efficient Pipeline Wavefront Phase Recovery for the CAFADIS Camera for Extremely Large Telescopes

PubMed Central

Magdaleno, Eduardo; Rodríguez, Manuel; Rodríguez-Ramos, José Manuel

2010-01-01

In this paper we show a fast, specialized hardware implementation of the wavefront phase recovery algorithm using the CAFADIS camera. The CAFADIS camera is a new plenoptic sensor patented by the Universidad de La Laguna (Canary Islands, Spain): international patent PCT/ES2007/000046 (WIPO publication number WO/2007/082975). It can simultaneously measure the wavefront phase and the distance to the light source in a real-time process. The pipeline algorithm is implemented using Field Programmable Gate Arrays (FPGA). These devices present architecture capable of handling the sensor output stream using a massively parallel approach and they are efficient enough to resolve several Adaptive Optics (AO) problems in Extremely Large Telescopes (ELTs) in terms of processing time requirements. The FPGA implementation of the wavefront phase recovery algorithm using the CAFADIS camera is based on the very fast computation of two dimensional fast Fourier Transforms (FFTs). Thus we have carried out a comparison between our very novel FPGA 2D-FFTa and other implementations. PMID:22315523

An efficient pipeline wavefront phase recovery for the CAFADIS camera for extremely large telescopes.

PubMed

Magdaleno, Eduardo; Rodríguez, Manuel; Rodríguez-Ramos, José Manuel

2010-01-01

In this paper we show a fast, specialized hardware implementation of the wavefront phase recovery algorithm using the CAFADIS camera. The CAFADIS camera is a new plenoptic sensor patented by the Universidad de La Laguna (Canary Islands, Spain): international patent PCT/ES2007/000046 (WIPO publication number WO/2007/082975). It can simultaneously measure the wavefront phase and the distance to the light source in a real-time process. The pipeline algorithm is implemented using Field Programmable Gate Arrays (FPGA). These devices present architecture capable of handling the sensor output stream using a massively parallel approach and they are efficient enough to resolve several Adaptive Optics (AO) problems in Extremely Large Telescopes (ELTs) in terms of processing time requirements. The FPGA implementation of the wavefront phase recovery algorithm using the CAFADIS camera is based on the very fast computation of two dimensional fast Fourier Transforms (FFTs). Thus we have carried out a comparison between our very novel FPGA 2D-FFTa and other implementations.

The Muslim football player and Ramadan: current challenges.

PubMed

Zerguini, Yacine; Ahmed, Qanta A; Dvorak, Jiri

2012-01-01

Islam is a monotheistic Abrahamic faith characterised by devotional orthopraxy. The actions expected of followers of Islam are closely prescribed in the Qur'an. Muslims understand Ramadan as a mandatory requirement, excused only in the event of illness, infirmity or extremes of age. Due to the increasing popularity of football among Muslims, more and more Muslim football players of all levels make the decision to follow the Ramadan fast while they need to practise and compete. Sports medicine clinicians and scientists have the responsibility to provide them with the knowledge and evidence on how exactly Ramadan fasting impacts on their performance and how to optimise their eating, drinking and sleeping in order to minimise negative effects of their religious practice, should any have been demonstrated. The first International Federation of Football Associations (FIFA) Medical Assessment and Research Centre (F-MARC) study concluded that biochemical, nutritional, subjective well-being and performance variables were not adversely affected in young male national level players who followed Ramadan fasting in a controlled environment. Match performance was however not measured and the study did not include elite level players, leading to the Ramadan consensus meeting in order to answer the remaining questions. The conclusions and recommendations published in this supplement suggest that the best coping strategies will remain individual - as is the choice to fast.

Enabling fast charging - A battery technology gap assessment

NASA Astrophysics Data System (ADS)

Ahmed, Shabbir; Bloom, Ira; Jansen, Andrew N.; Tanim, Tanvir; Dufek, Eric J.; Pesaran, Ahmad; Burnham, Andrew; Carlson, Richard B.; Dias, Fernando; Hardy, Keith; Keyser, Matthew; Kreuzer, Cory; Markel, Anthony; Meintz, Andrew; Michelbacher, Christopher; Mohanpurkar, Manish; Nelson, Paul A.; Robertson, David C.; Scoffield, Don; Shirk, Matthew; Stephens, Thomas; Vijayagopal, Ram; Zhang, Jiucai

2017-11-01

The battery technology literature is reviewed, with an emphasis on key elements that limit extreme fast charging. Key gaps in existing elements of the technology are presented as well as developmental needs. Among these needs are advanced models and methods to detect and prevent lithium plating; new positive-electrode materials which are less prone to stress-induced failure; better electrode designs to accommodate very rapid diffusion in and out of the electrode; measure temperature distributions during fast charge to enable/validate models; and develop thermal management and pack designs to accommodate the higher operating voltage.

Preventing Radicalisation to Extreme Positions in Children and Young People. What Does the Literature Tell Us and Should Educational Psychology Respond?

ERIC Educational Resources Information Center

Sewell, Alexandra; Hulusi, Halit

2016-01-01

Over the last five years the radicalisation of children and young people to extreme ideologies is fast developing as a new and important safeguarding issue for Local Authorities. Despite many high profile cases, there has yet to be a response from the educational psychology profession. This article seeks to explore the possible role for…

Kinematic Mechanisms of How Power Training Improves Healthy Old Adults' Gait Velocity.

PubMed

Beijersbergen, Chantal M I; Granacher, Urs; Gäbler, Martijn; Devita, Paul; Hortobágyi, Tibor

2017-01-01

Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and gait kinematics. As part of the Potsdam Gait Study, participants started with 10 wk of power training followed by 10 wk of detraining (n = 16), and participants started with a 10-wk control period followed by 10 wk of power training (n = 16). We measured gait kinematics (stride characteristic and joint kinematics) and isokinetic power of the ankle plantarflexor (20°·s, 40°·s, and 60°·s) and knee extensor and flexor (60°·s, 120°·s, and 180°·s) muscles at weeks 0, 10, and 20. Power training improved isokinetic muscle power by ~30% (P ≤ 0.001) and fast (5.9%, P < 0.05) but not habitual gait velocity. Ankle plantarflexor velocity measured during gait at fast pace decreased by 7.9% (P < 0.05). The changes isokinetic muscle power and joint kinematics did not correlate with increases in fast gait velocity. The mechanisms that increased fast gait velocity involved higher cadence (r = 0.86, P ≤ 0.001) rather than longer strides (r = 0.49, P = 0.066). Detraining did not reverse the training-induced increases in muscle power and fast gait velocity. Because increases in muscle power and modifications in joint kinematics did not correlate with increases in fast gait velocity, kinematic mechanisms seem to play a minor role in improving healthy old adults' fast gait velocity after power training.

Multigrid preconditioned conjugate-gradient method for large-scale wave-front reconstruction.

PubMed

Gilles, Luc; Vogel, Curtis R; Ellerbroek, Brent L

2002-09-01

We introduce a multigrid preconditioned conjugate-gradient (MGCG) iterative scheme for computing open-loop wave-front reconstructors for extreme adaptive optics systems. We present numerical simulations for a 17-m class telescope with n = 48756 sensor measurement grid points within the aperture, which indicate that our MGCG method has a rapid convergence rate for a wide range of subaperture average slope measurement signal-to-noise ratios. The total computational cost is of order n log n. Hence our scheme provides for fast wave-front simulation and control in large-scale adaptive optics systems.

Statistical innovations in diagnostic device evaluation.

PubMed

Yu, Tinghui; Li, Qin; Gray, Gerry; Yue, Lilly Q

2016-01-01

Due to rapid technological development, innovations in diagnostic devices are proceeding at an extremely fast pace. Accordingly, the needs for adopting innovative statistical methods have emerged in the evaluation of diagnostic devices. Statisticians in the Center for Devices and Radiological Health at the Food and Drug Administration have provided leadership in implementing statistical innovations. The innovations discussed in this article include: the adoption of bootstrap and Jackknife methods, the implementation of appropriate multiple reader multiple case study design, the application of robustness analyses for missing data, and the development of study designs and data analyses for companion diagnostics.

Imprints of fast-rotating massive stars in the Galactic Bulge.

PubMed

Chiappini, Cristina; Frischknecht, Urs; Meynet, Georges; Hirschi, Raphael; Barbuy, Beatriz; Pignatari, Marco; Decressin, Thibaut; Maeder, André

2011-04-28

The first stars that formed after the Big Bang were probably massive, and they provided the Universe with the first elements heavier than helium ('metals'), which were incorporated into low-mass stars that have survived to the present. Eight stars in the oldest globular cluster in the Galaxy, NGC 6522, were found to have surface abundances consistent with the gas from which they formed being enriched by massive stars (that is, with higher α-element/Fe and Eu/Fe ratios than those of the Sun). However, the same stars have anomalously high abundances of Ba and La with respect to Fe, which usually arises through nucleosynthesis in low-mass stars (via the slow-neutron-capture process, or s-process). Recent theory suggests that metal-poor fast-rotating massive stars are able to boost the s-process yields by up to four orders of magnitude, which might provide a solution to this contradiction. Here we report a reanalysis of the earlier spectra, which reveals that Y and Sr are also overabundant with respect to Fe, showing a large scatter similar to that observed in extremely metal-poor stars, whereas C abundances are not enhanced. This pattern is best explained as originating in metal-poor fast-rotating massive stars, which might point to a common property of the first stellar generations and even of the 'first stars'.

Ultrafast electronic relaxation in superheated bismuth

NASA Astrophysics Data System (ADS)

Gamaly, E. G.; Rode, A. V.

2013-01-01

Interaction of moving electrons with vibrating ions in the lattice forms the basis for many physical properties from electrical resistivity and electronic heat capacity to superconductivity. In ultrafast laser interaction with matter the electrons are heated much faster than the electron-ion energy equilibration, leading to a two-temperature state with electron temperature far above that of the lattice. The rate of temperature equilibration is governed by the strength of electron-phonon energy coupling, which is conventionally described by a coupling constant, neglecting the dependence on the electron and lattice temperature. The application of this constant to the observations of fast relaxation rate led to a controversial notion of ‘ultra-fast non-thermal melting’ under extreme electronic excitation. Here we provide theoretical grounds for a strong dependence of the electron-phonon relaxation time on the lattice temperature. We show, by taking proper account of temperature dependence, that the heating and restructuring of the lattice occurs much faster than were predicted on the assumption of a constant, temperature independent energy coupling. We applied the temperature-dependent momentum and energy transfer time to experiments on fs-laser excited bismuth to demonstrate that all the observed ultra-fast transformations of the transient state of bismuth are purely thermal in nature. The developed theory, when applied to ultrafast experiments on bismuth, provides interpretation of the whole variety of transient phase relaxation without the non-thermal melting conjecture.

Gravitational Waves From the Kerr/CFT Correspondence

NASA Astrophysics Data System (ADS)

Porfyriadis, Achilleas

Astronomical observation suggests the existence of near-extreme Kerr black holes in the sky. Properties of diffeomorphisms imply that dynamics of the near-horizon region of near-extreme Kerr are governed by an infinite-dimensional conformal symmetry. This symmetry may be exploited to analytically, rather than numerically, compute a variety of potentially observable processes. In this thesis we compute the gravitational radiation emitted by a small compact object that orbits in the near-horizon region and plunges into the horizon of a large rapidly rotating black hole. We study the holographically dual processes in the context of the Kerr/CFT correspondence and find our conformal field theory (CFT) computations in perfect agreement with the gravity results. We compute the radiation emitted by a particle on the innermost stable circular orbit (ISCO) of a rapidly spinning black hole. We confirm previous estimates of the overall scaling of the power radiated, but show that there are also small oscillations all the way to extremality. Furthermore, we reveal an intricate mode-by-mode structure in the flux to infinity, with only certain modes having the dominant scaling. The scaling of each mode is controlled by its conformal weight. Massive objects in adiabatic quasi-circular inspiral towards a near-extreme Kerr black hole quickly plunge into the horizon after passing the ISCO. The post-ISCO plunge trajectory is shown to be related by a conformal map to a circular orbit. Conformal symmetry of the near-horizon region is then used to compute analytically the gravitational radiation produced during the plunge phase. Most extreme-mass-ratio-inspirals of small compact objects into supermassive black holes end with a fast plunge from an eccentric last stable orbit. We use conformal transformations to analytically solve for the radiation emitted from various fast plunges into extreme and near-extreme Kerr black holes.

When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches.

PubMed

Muñoz, Victor; Cerminara, Michele

2016-09-01

Protein folding research stalled for decades because conventional experiments indicated that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay between dynamics and energetics resulting in myriad microscopic pathways. Ultrafast kinetic methods turned the field upside down by providing the means to probe fundamental aspects of folding, test theoretical predictions and benchmark simulations. Accordingly, experimentalists could measure the timescales for all relevant folding motions, determine the folding speed limit and confirm that folding barriers are entropic bottlenecks. Moreover, a catalogue of proteins that fold extremely fast (microseconds) could be identified. Such fast-folding proteins cross shallow free energy barriers or fold downhill, and thus unfold with minimal co-operativity (gradually). A new generation of thermodynamic methods has exploited this property to map folding landscapes, interaction networks and mechanisms at nearly atomic resolution. In parallel, modern molecular dynamics simulations have finally reached the timescales required to watch fast-folding proteins fold and unfold in silico All of these findings have buttressed the fundamentals of protein folding predicted by theory, and are now offering the first glimpses at the underlying mechanisms. Fast folding appears to also have functional implications as recent results connect downhill folding with intrinsically disordered proteins, their complex binding modes and ability to moonlight. These connections suggest that the coupling between downhill (un)folding and binding enables such protein domains to operate analogically as conformational rheostats. © 2016 The Author(s).

Zonisamide

MedlinePlus

... difficulty thinking of words or trouble speaking difficulty thinking or concentrating lack of coordination difficulty walking severe weakness severe muscle pain extreme tiredness loss of appetite fast, shallow breathing irregular heartbeat loss of consciousness Zonisamide ...

Fast detection of the fuzzy communities based on leader-driven algorithm

NASA Astrophysics Data System (ADS)

Fang, Changjian; Mu, Dejun; Deng, Zhenghong; Hu, Jun; Yi, Chen-He

2018-03-01

In this paper, we present the leader-driven algorithm (LDA) for learning community structure in networks. The algorithm allows one to find overlapping clusters in a network, an important aspect of real networks, especially social networks. The algorithm requires no input parameters and learns the number of clusters naturally from the network. It accomplishes this using leadership centrality in a clever manner. It identifies local minima of leadership centrality as followers which belong only to one cluster, and the remaining nodes are leaders which connect clusters. In this way, the number of clusters can be learned using only the network structure. The LDA is also an extremely fast algorithm, having runtime linear in the network size. Thus, this algorithm can be used to efficiently cluster extremely large networks.

Telescience - Concepts and contributions to the Extreme Ultraviolet Explorer mission

NASA Technical Reports Server (NTRS)

Marchant, Will; Dobson, Carl; Chakrabarti, Supriya; Malina, Roger F.

1987-01-01

It is shown how the contradictory goals of low-cost and fast data turnaround characterizing the Extreme Ultraviolet Explorer (EUVE) mission can be achieved via the early use of telescience style transparent tools and simulations. The use of transparent tools reduces the parallel development of capability while ensuring that valuable prelaunch experience is not lost in the operations phase. Efforts made to upgrade the 'EUVE electronics' simulator are described.

FAST-PT: a novel algorithm to calculate convolution integrals in cosmological perturbation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

McEwen, Joseph E.; Fang, Xiao; Hirata, Christopher M.

2016-09-01

We present a novel algorithm, FAST-PT, for performing convolution or mode-coupling integrals that appear in nonlinear cosmological perturbation theory. The algorithm uses several properties of gravitational structure formation—the locality of the dark matter equations and the scale invariance of the problem—as well as Fast Fourier Transforms to describe the input power spectrum as a superposition of power laws. This yields extremely fast performance, enabling mode-coupling integral computations fast enough to embed in Monte Carlo Markov Chain parameter estimation. We describe the algorithm and demonstrate its application to calculating nonlinear corrections to the matter power spectrum, including one-loop standard perturbation theorymore » and the renormalization group approach. We also describe our public code (in Python) to implement this algorithm. The code, along with a user manual and example implementations, is available at https://github.com/JoeMcEwen/FAST-PT.« less

Fast-track extreme event attribution: How fast can we disentangle thermodynamic (forced) and dynamic (internal) contributions?

NASA Astrophysics Data System (ADS)

Haustein, Karsten; Otto, Friederike; Uhe, Peter; Allen, Myles; Cullen, Heidi

2016-04-01

Within the last decade, extreme weather event attribution has emerged as a new field of science and garnered increasing attention from the wider scientific community and the public. Numerous methods have been put forward to determine the contribution of anthropogenic climate change to individual extreme weather events. So far nearly all such analyses were done months after an event has happened. First, we present our newly established method which can assess the fraction of attributable risk (FAR) of a severe weather event due to an external driver in real-time. The method builds on a large ensemble of atmosphere-only GCM/RCM simulations forced by seasonal forecast sea surface temperatures (SSTs). Taking the UK 2013/14 winter floods as an example, we demonstrate that the change in risk for heavy rainfall during the England floods due to anthropogenic climate change is of similar magnitude using either observed or seasonal forecast SSTs. While FAR is assumed to be independent from event-specific dynamic contributions due to anomalous circulation patterns as a first approximation, the risk of an event to occur under current conditions is clearly a function of the state of the atmosphere. The shorter the event, the more it is a result of chaotic internal weather variability. Hence we are interested to (1) attribute the event to thermodynamic and dynamic causes and to (2) establish a sensible time-scale for which we can make a useful and potentially robust attribution statement with regard to event-specific dynamics. Having tested the dynamic response of our model to SST conditions in January 2014, we find that observed SSTs are required to establish a discernible link between anomalous ocean temperatures and the atmospheric circulation over the North Atlantic in general and the UK in particular. However, for extreme events occurring under strongly anomalous SST patterns, associated with known low-frequency climate modes such as El Nino or La Nina, forecast SSTs can provide sufficient guidance to determine the dynamic contribution to the event on the basis of monthly mean values. No such link can be made (North Atlantic/Western Europe region) for shorter time-scales, unless the observed state of the circulation is taken as reference for the model analysis (e.g. Christidis et al. 2014). We present results from our most recent attribution analysis for the December 2015 UK floods (Storm Desmond and Eva), during which we find a robust teleconnection link between Pacific SSTs and North Atlantic Jetstream anomalies. This is true for both experiments, with forecast and observed SSTs. We propose a fast and simple analysis method based on the comparison of current climatological circulation patterns with actual and natural conditions. Alternative methods are discussed and analysed regarding their potential for fast-track attribution of the role of dynamics. Also, we briefly revisit the issue of internal vs forced dynamic contributions.

ISI-MIP: The Inter-Sectoral Impact Model Intercomparison Project

NASA Astrophysics Data System (ADS)

Huber, V.; Dahlemann, S.; Frieler, K.; Piontek, F.; Schewe, J.; Serdeczny, O.; Warszawski, L.

2013-12-01

The Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP) aims to synthesize the state-of-the-art knowledge of climate change impacts at different levels of global warming. The project's experimental design is formulated to distinguish the uncertainty introduced by the impact models themselves, from the inherent uncertainty in the climate projections and the variety of plausible socio-economic futures. The unique cross-sectoral scope of the project provides the opportunity to study cascading effects of impacts in interacting sectors and to identify regional 'hot spots' where multiple sectors experience extreme impacts. Another emphasis lies on the development of novel metrics to describe societal impacts of a warmer climate. We briefly outline the methodological framework, and then present selected results of the first, fast-tracked phase of ISI-MIP. The fast track brought together 35 global impact models internationally, spanning five sectors across human society and the natural world (agriculture, water, natural ecosystems, health and coastal infrastructure), and using the latest generation of global climate simulations (RCP projections from the CMIP5 archive) and socioeconomic drivers provided within the SSP process. We also introduce the second phase of the project, which will enlarge the scope of ISI-MIP by encompassing further impact sectors (e.g., forestry, fisheries, permafrost) and regional modeling approaches. The focus for the next round of simulations will be the validation and improvement of models based on historical observations and the analysis of variability and extreme events. Last but not least, we discuss the longer-term objective of ISI-MIP to initiate a coordinated, ongoing impact assessment process, driven by the entire impact community and in parallel with well-established climate model intercomparisons (CMIP).

Extreme Performance Scalable Operating Systems Final Progress Report (July 1, 2008 - October 31, 2011)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malony, Allen D; Shende, Sameer

This is the final progress report for the FastOS (Phase 2) (FastOS-2) project with Argonne National Laboratory and the University of Oregon (UO). The project started at UO on July 1, 2008 and ran until April 30, 2010, at which time a six-month no-cost extension began. The FastOS-2 work at UO delivered excellent results in all research work areas: * scalable parallel monitoring * kernel-level performance measurement * parallel I/0 system measurement * large-scale and hybrid application performance measurement * onlne scalable performance data reduction and analysis * binary instrumentation

Enabling fast charging – A battery technology gap assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmed, Shabbir; Bloom, Ira; Jansen, Andrew N.

The battery technology literature is reviewed, with an emphasis on key elements that limit extreme fast charging. Key gaps in existing elements of the technology are presented as well as developmental needs. Among these needs are advanced models and methods to detect and prevent lithium plating; new positive-electrode materials which are less prone to stress-induced failure; better electrode designs to accommodate very rapid diffusion in and out of the electrode; measure temperature distributions during fast charge to enable/validate models; and develop thermal management and pack designs to accommodate the higher operating voltage.

Enabling fast charging – A battery technology gap assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmed, Shabbir; Bloom, Ira; Jansen, Andrew N.

The battery technology literature is reviewed, with an emphasis on key elements that limit extreme fast charging. Key gaps in existing elements of the technology are presented as well as developmental needs. Among these needs are advanced models and methods to detect and prevent lithium plating; new positive-electrode materials which are less prone to stress-induced failure; better electrode designs to accommodate very rapid diffusion in and out of the electrode; measure temperature distributions during fast charge to enable / validate models; and develop thermal management and pack designs to accommodate the higher operating voltage.

Towards ultra-fast solvent evaporation, the development of a computer controlled solvent vapor annealing chamber

NASA Astrophysics Data System (ADS)

Nelson, Gunnar; Wong, J.; Drapes, C.; Grant, M.; Baruth, A.

Despite the promise of cheap and fast nanoscale ordering of block polymer thin films via solvent vapor annealing, a standardized, scalable production scheme remains elusive. Solvent vapor annealing exposes a nano-thin film to the vapors of one or more solvents with the goal of forming a swollen and mobile state to direct the self-assembly process by tuning surface energies and mediating unfavorable chain interactions. We have shown that optimized annealing conditions, where kinetic and thermal properties for crystal growth are extremely fast (<1s), exist at solvent concentrations just below the order-disorder transition of the film. However, when investigating the propagation of a given morphology into the bulk of a film during drying, the role of solvent evaporation comes under great scrutiny. During this process, the film undergoes a competition between two fronts; phase separation and kinetic trapping. Recent results in both theory and experiment point toward this critical element in controlling the resultant morphologies; however, no current method includes a controllable solvent evaporation rate at ultra-fast time scales. We report on a computer-controlled, pneumatically actuated chamber that provides control over solvent evaporation down to 15 ms. Furthermore, in situ spectral reflectance monitors solvent concentration with 10 ms temporal resolution and reveals several possible evaporation trajectories, ranging from linear to exponential to logarithmic. Funded by Dr. Randolph Ferlic Summer Research Scholarship and NASA Nebraska Space Grant.

Fast heating of ultrahigh-density plasma as a step towards laser fusion ignition.

PubMed

Kodama, R; Norreys, P A; Mima, K; Dangor, A E; Evans, R G; Fujita, H; Kitagawa, Y; Krushelnick, K; Miyakoshi, T; Miyanaga, N; Norimatsu, T; Rose, S J; Shozaki, T; Shigemori, K; Sunahara, A; Tampo, M; Tanaka, K A; Toyama, Y; Yamanaka, T; Zepf, M

2001-08-23

Modern high-power lasers can generate extreme states of matter that are relevant to astrophysics, equation-of-state studies and fusion energy research. Laser-driven implosions of spherical polymer shells have, for example, achieved an increase in density of 1,000 times relative to the solid state. These densities are large enough to enable controlled fusion, but to achieve energy gain a small volume of compressed fuel (known as the 'spark') must be heated to temperatures of about 108 K (corresponding to thermal energies in excess of 10 keV). In the conventional approach to controlled fusion, the spark is both produced and heated by accurately timed shock waves, but this process requires both precise implosion symmetry and a very large drive energy. In principle, these requirements can be significantly relaxed by performing the compression and fast heating separately; however, this 'fast ignitor' approach also suffers drawbacks, such as propagation losses and deflection of the ultra-intense laser pulse by the plasma surrounding the compressed fuel. Here we employ a new compression geometry that eliminates these problems; we combine production of compressed matter in a laser-driven implosion with picosecond-fast heating by a laser pulse timed to coincide with the peak compression. Our approach therefore permits efficient compression and heating to be carried out simultaneously, providing a route to efficient fusion energy production.

Fast temporal correlation between hard X-ray and ultraviolet continuum brightenings

NASA Technical Reports Server (NTRS)

Machado, Marcos E.; Mauas, Pablo J.

1986-01-01

Recent Solar Maximum Mission (SMM) observations have shown fast and simultaneous increases in hard X-rays (HXR, E25 keV) and ultraviolet continuum (UVC, lambda lambda approx. equals 1600 and 1388 A) radiation. A simple and natural explanation is given for this phenomenon to happen, which does not involve extreme conditions for energy transport processes, and confirms earlier results on the effect of XUV photoionization in the solar atmosphere.

Development of a High-Throughput Microwave Imaging System for Concealed Weapons Detection

DTIC Science & Technology

2016-07-15

hardware. Index Terms—Microwave imaging, multistatic radar, Fast Fourier Transform (FFT). I. INTRODUCTION Near-field microwave imaging is a non-ionizing...configuration, but its computational demands are extreme. Fast Fourier Transform (FFT) imaging has long been used to efficiently construct images sampled with...Simulated image of 25 point scatterers imaged at range 1.5m, with array layout depicted in Fig. 3. Left: image formed with Equation (5) ( Fourier

Physiological response to extreme fasting in subantarctic fur seal (Arctocephalus tropicalis) pups: metabolic rates, energy reserve utilization, and water fluxes.

PubMed

Verrier, Delphine; Groscolas, René; Guinet, Christophe; Arnould, John P Y

2009-11-01

Surviving prolonged fasting requires various metabolic adaptations, such as energy and protein sparing, notably when animals are simultaneously engaged in energy-demanding processes such as growth. Due to the intermittent pattern of maternal attendance, subantarctic fur seal pups have to repeatedly endure exceptionally long fasting episodes throughout the 10-mo rearing period while preparing for nutritional independence. Their metabolic responses to natural prolonged fasting (33.4 +/- 3.3 days) were investigated at 7 mo of age. Within 4-6 fasting days, pups shifted into a stage of metabolic economy characterized by a minimal rate of body mass loss (0.7%/day) and decreased resting metabolic rate (5.9 +/- 0.1 ml O(2)xkg(-1)xday(-1)) that was only 10% above the level predicted for adult terrestrial mammals. Field metabolic rate (289 +/- 10 kJxkg(-1)xday(-1)) and water influx (7.9 +/- 0.9 mlxkg(-1)xday(-1)) were also among the lowest reported for any young otariid, suggesting minimized energy allocation to behavioral activity and thermoregulation. Furthermore, lean tissue degradation was dramatically reduced. High initial adiposity (>48%) and predominant reliance on lipid catabolism likely contributed to the exceptional degree of protein sparing attained. Blood chemistry supported these findings and suggested utilization of alternative fuels, such as beta-hydroxybutyrate and de novo synthesized glucose from fat-released glycerol. Regardless of sex and body condition, pups tended to adopt a convergent strategy of extreme energy and lean body mass conservation that appears highly adaptive for it allows some tissue growth during the repeated episodes of prolonged fasting they experience throughout their development.

Evidence of Deterministic Components in the Apparent Randomness of GRBs: Clues of a Chaotic Dynamic

PubMed Central

Greco, G.; Rosa, R.; Beskin, G.; Karpov, S.; Romano, L.; Guarnieri, A.; Bartolini, C.; Bedogni, R.

2011-01-01

Prompt γ-ray emissions from gamma-ray bursts (GRBs) exhibit a vast range of extremely complex temporal structures with a typical variability time-scale significantly short – as fast as milliseconds. This work aims to investigate the apparent randomness of the GRB time profiles making extensive use of nonlinear techniques combining the advanced spectral method of the Singular Spectrum Analysis (SSA) with the classical tools provided by the Chaos Theory. Despite their morphological complexity, we detect evidence of a non stochastic short-term variability during the overall burst duration – seemingly consistent with a chaotic behavior. The phase space portrait of such variability shows the existence of a well-defined strange attractor underlying the erratic prompt emission structures. This scenario can shed new light on the ultra-relativistic processes believed to take place in GRB explosions and usually associated with the birth of a fast-spinning magnetar or accretion of matter onto a newly formed black hole. PMID:22355609

Evidence of deterministic components in the apparent randomness of GRBs: clues of a chaotic dynamic.

PubMed

Greco, G; Rosa, R; Beskin, G; Karpov, S; Romano, L; Guarnieri, A; Bartolini, C; Bedogni, R

2011-01-01

Prompt γ-ray emissions from gamma-ray bursts (GRBs) exhibit a vast range of extremely complex temporal structures with a typical variability time-scale significantly short - as fast as milliseconds. This work aims to investigate the apparent randomness of the GRB time profiles making extensive use of nonlinear techniques combining the advanced spectral method of the Singular Spectrum Analysis (SSA) with the classical tools provided by the Chaos Theory. Despite their morphological complexity, we detect evidence of a non stochastic short-term variability during the overall burst duration - seemingly consistent with a chaotic behavior. The phase space portrait of such variability shows the existence of a well-defined strange attractor underlying the erratic prompt emission structures. This scenario can shed new light on the ultra-relativistic processes believed to take place in GRB explosions and usually associated with the birth of a fast-spinning magnetar or accretion of matter onto a newly formed black hole.

Gaussian process tomography for soft x-ray spectroscopy at WEST without equilibrium information

NASA Astrophysics Data System (ADS)

Wang, T.; Mazon, D.; Svensson, J.; Li, D.; Jardin, A.; Verdoolaege, G.

2018-06-01

Gaussian process tomography (GPT) is a recently developed tomography method based on the Bayesian probability theory [J. Svensson, JET Internal Report EFDA-JET-PR(11)24, 2011 and Li et al., Rev. Sci. Instrum. 84, 083506 (2013)]. By modeling the soft X-ray (SXR) emissivity field in a poloidal cross section as a Gaussian process, the Bayesian SXR tomography can be carried out in a robust and extremely fast way. Owing to the short execution time of the algorithm, GPT is an important candidate for providing real-time reconstructions with a view to impurity transport and fast magnetohydrodynamic control. In addition, the Bayesian formalism allows quantifying uncertainty on the inferred parameters. In this paper, the GPT technique is validated using a synthetic data set expected from the WEST tokamak, and the results are shown of its application to the reconstruction of SXR emissivity profiles measured on Tore Supra. The method is compared with the standard algorithm based on minimization of the Fisher information.

Ultrahigh-speed X-ray imaging of hypervelocity projectiles

NASA Astrophysics Data System (ADS)

Miller, Stuart; Singh, Bipin; Cool, Steven; Entine, Gerald; Campbell, Larry; Bishel, Ron; Rushing, Rick; Nagarkar, Vivek V.

2011-08-01

High-speed X-ray imaging is an extremely important modality for healthcare, industrial, military and research applications such as medical computed tomography, non-destructive testing, imaging in-flight projectiles, characterizing exploding ordnance, and analyzing ballistic impacts. We report on the development of a modular, ultrahigh-speed, high-resolution digital X-ray imaging system with large active imaging area and microsecond time resolution, capable of acquiring at a rate of up to 150,000 frames per second. The system is based on a high-resolution, high-efficiency, and fast-decay scintillator screen optically coupled to an ultra-fast image-intensified CCD camera designed for ballistic impact studies and hypervelocity projectile imaging. A specially designed multi-anode, high-fluence X-ray source with 50 ns pulse duration provides a sequence of blur-free images of hypervelocity projectiles traveling at speeds exceeding 8 km/s (18,000 miles/h). This paper will discuss the design, performance, and high frame rate imaging capability of the system.

Dispersive Evolution of Nonlinear Fast Magnetoacoustic Wave Trains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pascoe, D. J.; Goddard, C. R.; Nakariakov, V. M., E-mail: D.J.Pascoe@warwick.ac.uk

2017-10-01

Quasi-periodic rapidly propagating wave trains are frequently observed in extreme ultraviolet observations of the solar corona, or are inferred by the quasi-periodic modulation of radio emission. The dispersive nature of fast magnetohydrodynamic waves in coronal structures provides a robust mechanism to explain the detected quasi-periodic patterns. We perform 2D numerical simulations of impulsively generated wave trains in coronal plasma slabs and investigate how the behavior of the trapped and leaky components depend on the properties of the initial perturbation. For large amplitude compressive perturbations, the geometrical dispersion associated with the waveguide suppresses the nonlinear steepening for the trapped wave train.more » The wave train formed by the leaky components does not experience dispersion once it leaves the waveguide and so can steepen and form shocks. The mechanism we consider can lead to the formation of multiple shock fronts by a single, large amplitude, impulsive event and so can account for quasi-periodic features observed in radio spectra.« less

Lab experiments investigating astrophysical jet physics

NASA Astrophysics Data System (ADS)

Bellan, Paul

2014-10-01

Dynamics relevant to astrophysical plasmas is being investigated in lab experiments having similar physics and topology, but much smaller time and space scales. High speed movies and numerical simulations both show that highly collimated MHD-driven plasma flows are a critical feature; these collimated flows can be considered to be a lab version of an astrophysical jet. Having both axial and azimuthal magnetic fields, the jet is effectively an axially lengthening plasma-confining flux tube with embedded helical magnetic field (flux rope). The jet velocity is in good agreement with an MHD acceleration model. Axial stagnation of the jet compresses embedded azimuthal magnetic flux and so results in jet self-collimation. Jets kink when they breach the Kruskal-Shafranov stability limit. The lateral acceleration of a sufficiently strong kink can provide an effective gravity which provides the environment for a spontaneously-developing, fine-scale, extremely fast Rayleigh-Taylor instability that erodes the current channel to be smaller than the ion skin depth. This cascade from the ideal MHD scale of the kink to the non-MHD ion skin depth scale can result in a fast magnetic reconnection whereby the jet breaks off from its source electrode. Supported by USDOE and NSF.

Fiber optic distributed chemical sensor for the real time detection of hydrocarbon fuel leaks

NASA Astrophysics Data System (ADS)

Mendoza, Edgar; Kempen, C.; Esterkin, Yan; Sun, Sunjian

2015-09-01

With the increase worldwide demand for hydrocarbon fuels and the vast development of new fuel production and delivery infrastructure installations around the world, there is a growing need for reliable hydrocarbon fuel leak detection technologies to provide safety and reduce environmental risks. Hydrocarbon leaks (gas or liquid) pose an extreme danger and need to be detected very quickly to avoid potential disasters. Gas leaks have the greatest potential for causing damage due to the explosion risk from the dispersion of gas clouds. This paper describes progress towards the development of a fast response, high sensitivity, distributed fiber optic fuel leak detection (HySense™) system based on the use of an optical fiber that uses a hydrocarbon sensitive fluorescent coating to detect the presence of fuel leaks present in close proximity along the length of the sensor fiber. The HySense™ system operates in two modes, leak detection and leak localization, and will trigger an alarm within seconds of exposure contact. The fast and accurate response of the sensor provides reliable fluid leak detection for pipelines, storage tanks, airports, pumps, and valves to detect and minimize any potential catastrophic damage.

Developing a Low-Cost System for 3d Data Acquisition

NASA Astrophysics Data System (ADS)

Kossieris, S.; Kourounioti, O.; Agrafiotis, P.; Georgopoulos, A.

2017-11-01

In this paper, a developed low-cost system is described, which aims to facilitate 3D documentation fast and reliably by acquiring the necessary data in outdoor environment for the 3D documentation of façades especially in the case of very narrow streets. In particular, it provides a viable solution for buildings up to 8-10m high and streets as narrow as 2m or even less. In cases like that, it is practically impossible or highly time-consuming to acquire images in a conventional way. This practice would lead to a huge number of images and long processing times. The developed system was tested in the narrow streets of a medieval village on the Greek island of Chios. There, in order to by-pass the problem of short taking distances, it was thought to use high definition action cameras together with a 360˚ camera, which are usually provided with very wide-angle lenses and are capable of acquiring images, of high definition, are rather cheap and, most importantly, extremely light. Results suggest that the system can perform fast 3D data acquisition adequate for deliverables of high quality.

Collaborative Software Development in Support of Fast Adaptive AeroSpace Tools (FAAST)

NASA Technical Reports Server (NTRS)

Kleb, William L.; Nielsen, Eric J.; Gnoffo, Peter A.; Park, Michael A.; Wood, William A.

2003-01-01

A collaborative software development approach is described. The software product is an adaptation of proven computational capabilities combined with new capabilities to form the Agency's next generation aerothermodynamic and aerodynamic analysis and design tools. To efficiently produce a cohesive, robust, and extensible software suite, the approach uses agile software development techniques; specifically, project retrospectives, the Scrum status meeting format, and a subset of Extreme Programming's coding practices are employed. Examples are provided which demonstrate the substantial benefits derived from employing these practices. Also included is a discussion of issues encountered when porting legacy Fortran 77 code to Fortran 95 and a Fortran 95 coding standard.

PLASMA DEVICE

DOEpatents

Baker, W.R.

1961-08-22

A device is described for establishing and maintaining a high-energy, rotational plasma for use as a fast discharge capacitor. A disc-shaped, current- conducting plasma is formed in an axinl magnetic field and a crossed electric field, thereby creating rotational kinetic enengy in the plasma. Such energy stored in the rotation of the plasma disc is substantial and is convertible tc electrical energy by generator action in an output line electrically coupled to the plasma volume. Means are then provided for discharging the electrical energy into an external circuit coupled to the output line to produce a very large pulse having an extremely rapid rise time in the waveform thereof. (AE C)

The Functional Arm Scale for Throwers (FAST)-Part II: Reliability and Validity of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes.

PubMed

Huxel Bliven, Kellie C; Snyder Valier, Alison R; Bay, R Curtis; Sauers, Eric L

2017-04-01

The Functional Arm Scale for Throwers (FAST) is an upper extremity (UE) region-specific and population-specific patient-reported outcome (PRO) scale developed to measure health-related quality of life in throwers with UE injuries. Stages I and II, described in a companion paper, of FAST development produced a 22-item scale and a 9-item pitcher module. Stage III of scale development, establishing reliability and validity of the FAST, is reported herein. To describe stage III of scale development: reliability and validity of the FAST. Cohort study (diagnosis); Level of evidence, 2. Data from throwing athletes collected over 5 studies were pooled to assess reliability and validity of the FAST. Reliability was estimated using FAST scores from 162 throwing athletes who were injured (n = 23) and uninjured (n = 139). Concurrent validity was estimated using FAST scores and Disabilities of the Arm, Shoulder, and Hand (DASH) and Kerlan-Jobe Orthopaedic Clinic (KJOC) scores from 106 healthy, uninjured throwing athletes. Known-groups validity was estimated using FAST scores from 557 throwing athletes who were injured (n = 142) and uninjured (n = 415). Reliability and validity were assessed using intraclass correlation coefficients (ICCs), and measurement error was assessed using standard error of measurement (SEM) and minimum detectable change (MDC). Receiver operating characteristic curves and sensitivity/specificity values were estimated for known-groups validity. Data from a separate group (n = 18) of postsurgical and nonoperative/conservative rehabilitation patients were analyzed to report responsiveness of the FAST. The FAST total, subscales, and pitcher module scores demonstrated excellent test-retest reliability (ICC, 0.91-0.98). The SEM 95 and MDC 95 for the FAST total score were 3.8 and 10.5 points, respectively. The SEM 95 and MDC 95 for the pitcher module score were 5.7 and 15.7 points, respectively. The FAST scores showed acceptable correlation with DASH (ICC, 0.49-0.82) and KJOC (ICC, 0.62-0.81) scores. The FAST total score classified 85.1% of players into the correct injury group. For predicting UE injury status, a FAST total cutoff score of 10.0 out of 100.0 was 91% sensitive and 75% specific, and a pitcher module score of 10.0 out of 100.0 was 87% sensitive and 78% specific. The FAST total score demonstrated responsiveness on several indices between intake and discharge time points. The FAST is a reliable, valid, and responsive UE region-specific and population-specific PRO scale for measuring patient-reported health care outcomes in throwing athletes with injury.

The Functional Arm Scale for Throwers (FAST)—Part II: Reliability and Validity of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes

PubMed Central

Huxel Bliven, Kellie C.; Snyder Valier, Alison R.; Bay, R. Curtis; Sauers, Eric L.

2017-01-01

Background: The Functional Arm Scale for Throwers (FAST) is an upper extremity (UE) region-specific and population-specific patient-reported outcome (PRO) scale developed to measure health-related quality of life in throwers with UE injuries. Stages I and II, described in a companion paper, of FAST development produced a 22-item scale and a 9-item pitcher module. Stage III of scale development, establishing reliability and validity of the FAST, is reported herein. Purpose: To describe stage III of scale development: reliability and validity of the FAST. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Data from throwing athletes collected over 5 studies were pooled to assess reliability and validity of the FAST. Reliability was estimated using FAST scores from 162 throwing athletes who were injured (n = 23) and uninjured (n = 139). Concurrent validity was estimated using FAST scores and Disabilities of the Arm, Shoulder, and Hand (DASH) and Kerlan-Jobe Orthopaedic Clinic (KJOC) scores from 106 healthy, uninjured throwing athletes. Known-groups validity was estimated using FAST scores from 557 throwing athletes who were injured (n = 142) and uninjured (n = 415). Reliability and validity were assessed using intraclass correlation coefficients (ICCs), and measurement error was assessed using standard error of measurement (SEM) and minimum detectable change (MDC). Receiver operating characteristic curves and sensitivity/specificity values were estimated for known-groups validity. Data from a separate group (n = 18) of postsurgical and nonoperative/conservative rehabilitation patients were analyzed to report responsiveness of the FAST. Results: The FAST total, subscales, and pitcher module scores demonstrated excellent test-retest reliability (ICC, 0.91-0.98). The SEM95 and MDC95 for the FAST total score were 3.8 and 10.5 points, respectively. The SEM95 and MDC95 for the pitcher module score were 5.7 and 15.7 points, respectively. The FAST scores showed acceptable correlation with DASH (ICC, 0.49-0.82) and KJOC (ICC, 0.62-0.81) scores. The FAST total score classified 85.1% of players into the correct injury group. For predicting UE injury status, a FAST total cutoff score of 10.0 out of 100.0 was 91% sensitive and 75% specific, and a pitcher module score of 10.0 out of 100.0 was 87% sensitive and 78% specific. The FAST total score demonstrated responsiveness on several indices between intake and discharge time points. Conclusion: The FAST is a reliable, valid, and responsive UE region-specific and population-specific PRO scale for measuring patient-reported health care outcomes in throwing athletes with injury. PMID:28451614

POPULATION I WOLF-RAYET RUNAWAY STARS: THE CASE OF WR124 AND ITS EXPANDING NEBULA M1-67

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchenko, S. V.; Moffat, A. F. J.; Crowther, P. A., E-mail: sergey.marchenko@ssaihq.co, E-mail: moffat@astro.umontreal.c, E-mail: Paul.Crowther@sheffield.ac.u

2010-11-20

In 1997 and 2008 we used the WFPC2 camera on board the Hubble Space Telescope to obtain two sets of narrow-band H{alpha} images of the runaway Wolf-Rayet (WR) star WR 124 surrounded by its nebula M1-67. This two-epoch imaging provides an expansion parallax and thus a practically assumption-free geometric distance to the nebula, d = 3.35 {+-} 0.67 kpc. Combined with the global velocity distribution in the ejected nebula, this confirms the extreme runaway status of WR 124. WR stars embedded within such ejection nebulae at the point of core collapse would produce different supernova characteristics from those expected formore » stars surrounded by wind-filled cavities. In galaxies with extremely low ambient metallicity, Z {<=} 10{sup -3} Z {sub sun}, {gamma}-ray bursts originating from fast-moving runaway WR stars may produce afterglows which appear to be coming from regions with a relatively homogeneous circumburst medium.« less

Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus.

PubMed

Kintses, Bálint; Simon, Zoltán; Gyimesi, Máté; Tóth, Júlia; Jelinek, Balázs; Niedetzky, Csaba; Kovács, Mihály; Málnási-Csizmadia, András

2006-12-15

We constructed a "temperature-jump/stopped-flow" apparatus that allows us to study fast enzyme reactions at extremely high temperatures. This apparatus is a redesigned stopped-flow which is capable of mixing the reactants on a submillisecond timescale concomitant with a temperature-jump even as large as 60 degrees C. We show that enzyme reactions that are faster than the denaturation process can be investigated above denaturation temperatures. In addition, the temperature-jump/stopped-flow enables us to investigate at physiological temperature the mechanisms of many human enzymes, which was impossible until now because of their heat instability. Furthermore, this technique is extremely useful in studying the progress of heat-induced protein unfolding. The temperature-jump/stopped-flow method combined with the application of structure-specific fluorescence signals provides novel opportunities to study the stability of certain regions of enzymes and identify the unfolding-initiating regions of proteins. The temperature-jump/stopped-flow technique may become a breakthrough in exploring new features of enzymes and the mechanism of unfolding processes.

Run-up parameterization and beach vulnerability assessment on a barrier island: a downscaling approach

NASA Astrophysics Data System (ADS)

Medellín, G.; Brinkkemper, J. A.; Torres-Freyermuth, A.; Appendini, C. M.; Mendoza, E. T.; Salles, P.

2016-01-01

We present a downscaling approach for the study of wave-induced extreme water levels at a location on a barrier island in Yucatán (Mexico). Wave information from a 30-year wave hindcast is validated with in situ measurements at 8 m water depth. The maximum dissimilarity algorithm is employed for the selection of 600 representative cases, encompassing different combinations of wave characteristics and tidal level. The selected cases are propagated from 8 m water depth to the shore using the coupling of a third-generation wave model and a phase-resolving non-hydrostatic nonlinear shallow-water equation model. Extreme wave run-up, R2%, is estimated for the simulated cases and can be further employed to reconstruct the 30-year time series using an interpolation algorithm. Downscaling results show run-up saturation during more energetic wave conditions and modulation owing to tides. The latter suggests that the R2% can be parameterized using a hyperbolic-like formulation with dependency on both wave height and tidal level. The new parametric formulation is in agreement with the downscaling results (r2 = 0.78), allowing a fast calculation of wave-induced extreme water levels at this location. Finally, an assessment of beach vulnerability to wave-induced extreme water levels is conducted at the study area by employing the two approaches (reconstruction/parameterization) and a storm impact scale. The 30-year extreme water level hindcast allows the calculation of beach vulnerability as a function of return periods. It is shown that the downscaling-derived parameterization provides reasonable results as compared with the numerical approach. This methodology can be extended to other locations and can be further improved by incorporating the storm surge contributions to the extreme water level.

A daily wetness index from satellite gravity for near-real time global monitoring of hydrological extremes

NASA Astrophysics Data System (ADS)

Gouweleeuw, Ben; Kvas, Andreas; Gruber, Christian; Mayer-Gürr, Torsten; Flechtner, Frank; Hasan, Mehedi; Güntner, Andreas

2017-04-01

Since April 2002, the Gravity Recovery and Climate Experiment (GRACE) satellite mission has been churning out water storage anomaly data, which has been shown to be a unique descriptor of large-scale hydrological extreme events. Nonetheless, efforts to assess the comprehensive information from GRACE on total water storage variations for near-real time flood or drought monitoring have been limited so far, primarily due to its coarse temporal (weekly to monthly) and spatial (> 150.000 km2) resolution and the latency of standard products of about 2 months,. Pending the status of the aging GRACE satellite mission, the Horizon 2020 funded EGSIEM (European Gravity Service for Improved Emergency Management) project is scheduled to launch a 6 month duration near-real time test run of GRACE gravity field data from April 2017 onward, which will provide daily gridded data with a latency of 5 days. This fast availability allows the monitoring of total water storage variations related to hydrological extreme events, as they occur, as opposed to a 'confirmation after occurrence', which is the current situation. This contribution proposes a global GRACE-derived gridded wetness indicator, expressed as a gravity anomaly in dimensionless units of standard deviation. Results of a retrospective evaluation (April 2002-December 2015) of the proposed index against databases of hydrological extremes will be presented. It is shown that signals for large extreme floods related to heavy/monsoonal rainfall are picked up really well in the Southern Hemisphere and lower Northern Hemisphere (Africa, S-America, Australia, S-Asia), while extreme floods in the Northern Hemisphere (Russia) related to snow melt are often not. The latter is possibly related to a lack of mass movement over longer distances, e.g. when melt water is not drained due to river ice blocking.

A novel upper limb rehabilitation system with self-driven virtual arm illusion.

PubMed

Aung, Yee Mon; Al-Jumaily, Adel; Anam, Khairul

2014-01-01

This paper proposes a novel upper extremity rehabilitation system with virtual arm illusion. It aims for fast recovery from lost functions of the upper limb as a result of stroke to provide a novel rehabilitation system for paralyzed patients. The system is integrated with a number of technologies that include Augmented Reality (AR) technology to develop game like exercise, computer vision technology to create the illusion scene, 3D modeling and model simulation, and signal processing to detect user intention via EMG signal. The effectiveness of the developed system has evaluated via usability study and questionnaires which is represented by graphical and analytical methods. The evaluation provides with positive results and this indicates the developed system has potential as an effective rehabilitation system for upper limb impairment.

Shock-induced reaction synthesis of cubic boron nitride

NASA Astrophysics Data System (ADS)

Beason, M. T.; Pauls, J. M.; Gunduz, I. E.; Rouvimov, S.; Manukyan, K. V.; Matouš, K.; Son, S. F.; Mukasyan, A.

2018-04-01

Here, we report ultra-fast (0.1-5 μs) shock-induced reactions in the 3B-TiN system, leading to the direct synthesis of cubic boron nitride, which is extremely rare in nature and is the second hardest material known. Composite powders were produced through high-energy ball milling to provide intimate mixing and subsequently shocked using an explosive charge. High-resolution transmission electron microscopy and X-ray diffraction confirm the formation of nanocrystalline grains of c-BN produced during the metathetical reaction between boron and titanium nitride. Our results illustrate the possibility of rapid reactions enabled by high-energy ball milling possibly occurring in the solid state on incredibly short timescales. This process may provide a route for the discovery and fabrication of advanced compounds.

Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation.

PubMed

Eberhardt, Mirjam; Nakajima, Julika; Klinger, Alexandra B; Neacsu, Cristian; Hühne, Kathrin; O'Reilly, Andrias O; Kist, Andreas M; Lampe, Anne K; Fischer, Kerstin; Gibson, Jane; Nau, Carla; Winterpacht, Andreas; Lampert, Angelika

2014-01-24

Inherited erythromelalgia (IEM) causes debilitating episodic neuropathic pain characterized by burning in the extremities. Inherited "paroxysmal extreme pain disorder" (PEPD) differs in its clinical picture and affects proximal body areas like the rectal, ocular, or jaw regions. Both pain syndromes have been linked to mutations in the voltage-gated sodium channel Nav1.7. Electrophysiological characterization shows that IEM-causing mutations generally enhance activation, whereas mutations leading to PEPD alter fast inactivation. Previously, an A1632E mutation of a patient with overlapping symptoms of IEM and PEPD was reported (Estacion, M., Dib-Hajj, S. D., Benke, P. J., Te Morsche, R. H., Eastman, E. M., Macala, L. J., Drenth, J. P., and Waxman, S. G. (2008) NaV1.7 Gain-of-function mutations as a continuum. A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders. J. Neurosci. 28, 11079-11088), displaying a shift of both activation and fast inactivation. Here, we characterize a new mutation of Nav1.7, A1632T, found in a patient suffering from IEM. Although transfection of A1632T in sensory neurons resulted in hyperexcitability and spontaneous firing of dorsal root ganglia (DRG) neurons, whole-cell patch clamp of transfected HEK cells revealed that Nav1.7 activation was unaltered by the A1632T mutation but that steady-state fast inactivation was shifted to more depolarized potentials. This is a characteristic normally attributed to PEPD-causing mutations. In contrast to the IEM/PEPD crossover mutation A1632E, A1632T failed to slow current decay (i.e. open-state inactivation) and did not increase resurgent currents, which have been suggested to contribute to high-frequency firing in physiological and pathological conditions. Reduced fast inactivation without increased resurgent currents induces symptoms of IEM, not PEPD, in the new Nav1.7 mutation, A1632T. Therefore, persistent and resurgent currents are likely to determine whether a mutation in Nav1.7 leads to IEM or PEPD.

Fast Fourier transformation results from gamma-ray burst profiles

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa; Norris, Jay P.; Fishman, Gerald J.; Meegan, Charles A.; Wilson, Robert B.; Paciesas, W. S.

1992-01-01

Several gamma-ray bursts in the BATSE data have sufficiently long durations and complex temporal structures with pulses that appear to be spaced quasi-periodically. In order to test and quantify these periods we have applied fast Fourier transformations (FFT) to all these events. We have also performed cross spectral analyses of the FFT of the two extreme (high-low) energy bands in each case to determine the lead/lag of the pulses in different energies.

Extension of Viscoplasticity Based on Overstress to Capture the Effects of Prior Aging on the Time Dependent Deformation Behavior of a High-Temperature Polymer: Experiments and Modeling

DTIC Science & Technology

2008-10-01

the standard model characterization procedure is based on creep and recovery tests, where loading and unloading occurs at a fast rate of 1.0 MPa/s...σ − g[ǫ] and on d̊g[ǫ] dǫ = E, where g̊ is defined as the equilibrium stress g[ ] for extremely fast loading. For this case, the stress-strain curves...Strain S tr es s Strain Rate Slow Strain Rate Medium Strain Rate Fast Plastic Flow Fully Established Figure 2.10: Stress Strain Curve Schematic

Adherence evaluation of vented chest seals in a swine skin model.

PubMed

Arnaud, Françoise; Maudlin-Jeronimo, Eric; Higgins, Adam; Kheirabadi, Bijan; McCarron, Richard; Kennedy, Daniel; Housler, Greggory

2016-10-01

Perforation of the chest (open pneumothorax) with and without lung injury can cause air accumulation in the chest, positive intrapleural pressure and lead to tension pneumothorax if untreated. The performance of chest seals to prevent tension physiology depends partially on their ability to adhere to the skin and seal the chest wound. Novel non-occlusive vented chest seals were assessed for their adhesiveness on skin of live swine under normal and extreme environmental conditions to simulate austere battlefield conditions. Chest seals were applied on the back of the swine on skin that was soiled by various environmental contaminants to represent battlefield situations. A peeling (horizontal rim peeling) and detachment and breaching (vertical pulling) techniques were used to quantify the adhesive performance of vented chest seals. Among eight initially selected vented seals, five (Bolin, Russell, Fast breathe, Hyfin and SAM) were further down-selected based on their superior adherence scores at ambient temperatures. The adherence of these seals was then assessed after approximately 17h storage at extreme cold (-19.5°C) and hot (71.5°C) temperatures. Adherence scores for peeling (above 90%) and detachment scores (less than 25%) were comparable for four vented chest seals when tested at ambient temperature, except for the Bolin seal which had higher breaching. Under extreme storage temperatures, adherence peeling scores were comparable to those at ambient temperatures for four chest seals. Scores were significantly lower for the Bolin seal at extreme temperatures. This seal also had the highest detachment and breaching scores. In contrast, the Russell, Fast breathe, Hyfin and SAM seals showed similar ability to stay air tight without breaching after hot storage. No significant difference was found in skin adherence of the five vented chest seals at ambient temperature and the four seals (Russell, Fast breathe, Hyfin and SAM) maintained superior adherence even after exposure to extreme temperatures compared to the Bolin. To select the most effective product from the 5 selected vented chest seals, further functional evaluation of the valve of these chest seals on a chest wound with the potential for tension in the pneumothorax or hemopneumothorax is warranted. Copyright © 2016 Elsevier Ltd. All rights reserved.

Analysis of long-term changes in extreme climatic indices: a case study of the Mediterranean climate, Marmara Region, Turkey

NASA Astrophysics Data System (ADS)

Abbasnia, Mohsen; Toros, Hüseyin

2018-05-01

This study aimed to analyze extreme temperature and precipitation indices at seven stations in the Marmara Region of Turkey for the period 1961-2016. The trend of temperature indices showed that the warm-spell duration and the numbers of summer days, tropical nights, warm nights, and warm days have increased, while the cold-spell duration and number of ice days, cool nights, and cool days have decreased across the Marmara Region. Additionally, the diurnal temperature range has slightly increased at most of the stations. A majority of stations have shown significant warming trends for warm days and warm nights throughout the study area, whereas warm extremes and night-time based temperature indices have shown stronger trends compared to cold extremes and day-time indices. The analysis of precipitation indices has mostly shown increasing trends in consecutive dry days and increasing trends in annual rainfall, rainfall intensity for inland and urban stations, especially for stations in Sariyer and Edirne, which are affected by a fast rate of urbanization. Overall, a large proportion of study stations have experienced an increase in annual precipitation and heavy precipitation events, although there was a low percentage of results that was significant. Therefore, it is expected that the rainfall events will tend to become shorter and more intense, the occurrence of temperature extremes will become more pronounced in favor of hotter events, and there will be an increase in the atmospheric moisture content over the Marmara Region. This provides regional evidence for the importance of ongoing research on climate change.

Structural Extremes in a Cretaceous Dinosaur

PubMed Central

Sereno, Paul C.; Wilson, Jeffrey A.; Witmer, Lawrence M.; Whitlock, John A.; Maga, Abdoulaye; Ide, Oumarou; Rowe, Timothy A.

2007-01-01

Fossils of the Early Cretaceous dinosaur, Nigersaurus taqueti, document for the first time the cranial anatomy of a rebbachisaurid sauropod. Its extreme adaptations for herbivory at ground-level challenge current hypotheses regarding feeding function and feeding strategy among diplodocoids, the larger clade of sauropods that includes Nigersaurus. We used high resolution computed tomography, stereolithography, and standard molding and casting techniques to reassemble the extremely fragile skull. Computed tomography also allowed us to render the first endocast for a sauropod preserving portions of the olfactory bulbs, cerebrum and inner ear, the latter permitting us to establish habitual head posture. To elucidate evidence of tooth wear and tooth replacement rate, we used photographic-casting techniques and crown thin sections, respectively. To reconstruct its 9-meter postcranial skeleton, we combined and size-adjusted multiple partial skeletons. Finally, we used maximum parsimony algorithms on character data to obtain the best estimate of phylogenetic relationships among diplodocoid sauropods. Nigersaurus taqueti shows extreme adaptations for a dinosaurian herbivore including a skull of extremely light construction, tooth batteries located at the distal end of the jaws, tooth replacement as fast as one per month, an expanded muzzle that faces directly toward the ground, and hollow presacral vertebral centra with more air sac space than bone by volume. A cranial endocast provides the first reasonably complete view of a sauropod brain including its small olfactory bulbs and cerebrum. Skeletal and dental evidence suggests that Nigersaurus was a ground-level herbivore that gathered and sliced relatively soft vegetation, the culmination of a low-browsing feeding strategy first established among diplodocoids during the Jurassic. PMID:18030355

A maximally stable extremal region based scene text localization method

NASA Astrophysics Data System (ADS)

Xiao, Chengqiu; Ji, Lixin; Gao, Chao; Li, Shaomei

2015-07-01

Text localization in natural scene images is an important prerequisite for many content-based image analysis tasks. This paper proposes a novel text localization algorithm. Firstly, a fast pruning algorithm is designed to extract Maximally Stable Extremal Regions (MSER) as basic character candidates. Secondly, these candidates are filtered by using the properties of fitting ellipse and the distribution properties of characters to exclude most non-characters. Finally, a new extremal regions projection merging algorithm is designed to group character candidates into words. Experimental results show that the proposed method has an advantage in speed and achieve relatively high precision and recall rates than the latest published algorithms.

Extreme fluctuations of active Brownian motion

NASA Astrophysics Data System (ADS)

Pietzonka, Patrick; Kleinbeck, Kevin; Seifert, Udo

2016-05-01

In active Brownian motion, an internal propulsion mechanism interacts with translational and rotational thermal noise and other internal fluctuations to produce directed motion. We derive the distribution of its extreme fluctuations and identify its universal properties using large deviation theory. The limits of slow and fast internal dynamics give rise to a kink-like and parabolic behavior of the corresponding rate functions, respectively. For dipolar Janus particles in two- and three-dimensions interacting with a field, we predict a novel symmetry akin to, but different from, the one related to entropy production. Measurements of these extreme fluctuations could thus be used to infer properties of the underlying, often hidden, network of states.

Fast track in hip arthroplasty

PubMed Central

Hansen, Torben Bæk

2017-01-01

‘Fast-track’ surgery was introduced more than 20 years ago and may be defined as a co-ordinated peri-operative approach aimed at reducing surgical stress and facilitating post-operative recovery.The fast-track programmes have now been introduced into total hip arthroplasty (THA) surgery with reduction in post-operative length of stay, shorter convalescence and rapid functional recovery without increased morbidity and mortality. This has been achieved by focusing on a multidisciplinary collaboration and establishing ‘fast-track’ units, with a well-defined organisational set-up tailored to deliver an accelerated peri-operative course of fast-track surgical THA procedures.Fast-track THA surgery now works extremely well in the standard THA patient. However, all patients are different and fine-tuning of the multiple areas in fast-track pathways to get patients with special needs or high co-morbidity burden through a safe and effective fast-track THA pathway is important.In this narrative review, the principles of fast-track THA surgery are presented together with the present status of implementation and perspectives for further improvements. Cite this article: EFORT Open Rev 2017;2. DOI: 10.1302/2058-5241.2.160060. Originally published online at www.efortopenreviews.org PMID:28630756

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keyser, Matthew A

Present-day thermal management systems for battery electric vehicles are inadequate in limiting the maximum temperature rise of the battery during extreme fast charging. If the battery thermal management system is not designed correctly, the temperature of the cells could reach abuse temperatures and potentially send the cells into thermal runaway. Furthermore, the cell and battery interconnect design needs to be improved to meet the lifetime expectations of the consumer. Each of these aspects is explored and addressed as well as outlining where the heat is generated in a cell, the efficiencies of power and energy cells, and what type ofmore » battery thermal management solutions are available in today's market. Thermal management is not a limiting condition with regard to extreme fast charging, but many factors need to be addressed especially for future high specific energy density cells to meet U.S. Department of Energy cost and volume goals.« less

Supramolecular water oxidation with Ru-bda-based catalysts.

PubMed

Richmond, Craig J; Matheu, Roc; Poater, Albert; Falivene, Laura; Benet-Buchholz, Jordi; Sala, Xavier; Cavallo, Luigi; Llobet, Antoni

2014-12-22

Extremely slow and extremely fast new water oxidation catalysts based on the Ru-bda (bda=2,2'-bipyridine-6,6'-dicarboxylate) systems are reported with turnover frequencies in the range of 1 and 900 cycles s(-1) , respectively. Detailed analyses of the main factors involved in the water oxidation reaction have been carried out and are based on a combination of reactivity tests, electrochemical experiments, and DFT calculations. These analyses give a convergent interpretation that generates a solid understanding of the main factors involved in the water oxidation reaction, which in turn allows the design of catalysts with very low energy barriers in all the steps involved in the water oxidation catalytic cycle. We show that for this type of system π-stacking interactions are the key factors that influence reactivity and by adequately controlling them we can generate exceptionally fast water oxidation catalysts. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A k-Vector Approach to Sampling, Interpolation, and Approximation

NASA Astrophysics Data System (ADS)

Mortari, Daniele; Rogers, Jonathan

2013-12-01

The k-vector search technique is a method designed to perform extremely fast range searching of large databases at computational cost independent of the size of the database. k-vector search algorithms have historically found application in satellite star-tracker navigation systems which index very large star catalogues repeatedly in the process of attitude estimation. Recently, the k-vector search algorithm has been applied to numerous other problem areas including non-uniform random variate sampling, interpolation of 1-D or 2-D tables, nonlinear function inversion, and solution of systems of nonlinear equations. This paper presents algorithms in which the k-vector search technique is used to solve each of these problems in a computationally-efficient manner. In instances where these tasks must be performed repeatedly on a static (or nearly-static) data set, the proposed k-vector-based algorithms offer an extremely fast solution technique that outperforms standard methods.

Greenland outlet glacier dynamics from Extreme Ice Survey (EIS) photogrammetry

NASA Astrophysics Data System (ADS)

Hawbecker, P.; Box, J. E.; Balog, J. D.; Ahn, Y.; Benson, R. J.

2010-12-01

Time Lapse cameras fill gaps in our observational capabilities: 1. By providing much higher temporal resolution than offered by conventional airborne or satellite remote sensing. 2. While GPS or auto-theodolite observations can provide higher time resolution data than from photogrammetry, survival of these instruments on the hazardous glacier surface is limited, plus, the maintenance of such systems can be more expensive than the maintenance of a terrestrial photogrammetry installation. 3. Imagery provide a high spatial density of observations across the glacier surface, higher than is realistically available from GPS or other in-situ observations. 4. time lapse cameras provide observational capabilities in Eulerian and Lagrangian frames while GPS or theodolite targets, going along for a ride on the glacier, provide only Lagrangian data. Photogrammetry techniques are applied to a year-plus of images from multiple west Greenland glaciers to determine the glacier front horizontal velocity variations at hourly to seasonal time scales. The presentation includes comparisons between glacier front velocities and: 1. surface melt rates inferred from surface air temperature and solar radiation observations; 2. major calving events identified from camera images; 3. surface and near-surface ocean temperature; 4. land-fast sea ice breakup; 5. tidal variations; 6. supra-glacial melt lake drainage events observed in daily optical satellite imagery; and 7.) GPS data. Extreme Ice Survey (EIS) time lapse camera overlooking the Petermann glacier, installed to image glacier dynamics and to capture the predicted ice "island" detachment.

Very fast optical flaring from a possible new Galactic magnetar.

PubMed

Stefanescu, A; Kanbach, G; Słowikowska, A; Greiner, J; McBreen, S; Sala, G

2008-09-25

Highly luminous rapid flares are characteristic of processes around compact objects like white dwarfs, neutron stars and black holes. In the high-energy regime of X-rays and gamma-rays, outbursts with variabilities on timescales of seconds or less are routinely observed, for example in gamma-ray bursts or soft gamma-ray repeaters. At optical wavelengths, flaring activity on such timescales has not been observed, other than from the prompt phase of one exceptional gamma-ray burst. This is mostly due to the fact that outbursts with strong, fast flaring are usually discovered in the high-energy regime; most optical follow-up observations of such transients use instruments with integration times exceeding tens of seconds, which are therefore unable to resolve fast variability. Here we show the observation of extremely bright and rapid optical flaring in the Galactic transient SWIFT J195509.6+261406. Our optical light curves are phenomenologically similar to high-energy light curves of soft gamma-ray repeaters and anomalous X-ray pulsars, which are thought to be neutron stars with extremely high magnetic fields (magnetars). This suggests that similar processes are in operation, but with strong emission in the optical, unlike in the case of other known magnetars.

Mode Conversion of a Solar Extreme-ultraviolet Wave over a Coronal Cavity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zong, Weiguo; Dai, Yu, E-mail: ydai@nju.edu.cn

2017-01-10

We report on observations of an extreme-ultraviolet (EUV) wave event in the Sun on 2011 January 13 by Solar Terrestrial Relations Observatory and Solar Dynamics Observatory in quadrature. Both the trailing edge and the leading edge of the EUV wave front in the north direction are reliably traced, revealing generally compatible propagation velocities in both perspectives and a velocity ratio of about 1/3. When the wave front encounters a coronal cavity near the northern polar coronal hole, the trailing edge of the front stops while its leading edge just shows a small gap and extends over the cavity, meanwhile gettingmore » significantly decelerated but intensified. We propose that the trailing edge and the leading edge of the northward propagating wave front correspond to a non-wave coronal mass ejection component and a fast-mode magnetohydrodynamic wave component, respectively. The interaction of the fast-mode wave and the coronal cavity may involve a mode conversion process, through which part of the fast-mode wave is converted to a slow-mode wave that is trapped along the magnetic field lines. This scenario can reasonably account for the unusual behavior of the wave front over the coronal cavity.« less

Phenotypic disparity of the elbow joint in domestic dogs and wild carnivores.

PubMed

Figueirido, Borja

2018-05-16

In this article, I use geometric morphometrics in 2D from a sample of 366 elbow joints to quantify phenotypic disparity in domestic dog breeds, in wild canids, and across the order Carnivora. The elbow joint is a well-established morphological indicator of forearm motion and, by extension, of functional adaptations towards locomotor or predatory behavior in living carnivores. The study of the elbow joint in domestic dogs allows the exploration of potential convergences between (i) pursuit predators and fast-running dogs, and (ii) ambush predators and fighting breeds. The results indicate that elbow shape disparity among domestic dogs exceeds that in wolves; it is comparable to the disparity of wild Caninae, but is significantly lower than the one observed throughout Canidae and Carnivora. Moreover, fast-running and fighting breeds are not convergent in elbow joint shape with extreme pursuit and ambush wild carnivores, respectively. The role of artificial selection and developmental constraints in shaping limb phenotypic disparity through the extremely fast evolution of the domestic dog is discussed in the light of this new evidence. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Some practical universal noiseless coding techniques, part 2

NASA Technical Reports Server (NTRS)

Rice, R. F.; Lee, J. J.

1983-01-01

This report is an extension of earlier work (Part 1) which provided practical adaptive techniques for the efficient noiseless coding of a broad class of data sources characterized by only partially known and varying statistics (JPL Publication 79-22). The results here, while still claiming such general applicability, focus primarily on the noiseless coding of image data. A fairly complete and self-contained treatment is provided. Particular emphasis is given to the requirements of the forthcoming Voyager II encounters of Uranus and Neptune. Performance evaluations are supported both graphically and pictorially. Expanded definitions of the algorithms in Part 1 yield a computationally improved set of options for applications requiring efficient performance at entropies above 4 bits/sample. These expanded definitions include as an important subset, a somewhat less efficient but extremely simple "FAST' compressor which will be used at the Voyager Uranus encounter. Additionally, options are provided which enhance performance when atypical data spikes may be present.

Are temporal characteristics of fast repetitive oscillating movement invariant?

PubMed

Gutnik, B J; Nicholson, J; Go, W; Gale, D; Nash, D

2003-06-01

Validation of the proportional duration model was attempted using very fast single-joint repetitive horizontal abductive-adductive movements of the stretched upper extremity with minimal cognitive input. Participants drew oscillating horizontal lines during 20 sec. over relatively short distances as quickly as possible without visual feedback. Spatial, temporal, and kinetic parameters were analysed. The amplitude and the time spent accelerating, decelerating, and reversing in both directions of each experimental line were recorded and related to the centre of gravity of the upper extremity. The accelerations of the centre of mass of the upper extremity were calculated and used to calculate the forces involved. The ratios of durations were compared and intercorrelated for the two fastest, two average, and two slowest cycles from each participant. Results exhibited significant standard deviations and variability of temporal and kinetic parameters within individual trials. The number of significant coefficients of correlation within individual trials was small despite the controlling influence of the same generalised motor program. The proportional duration model did not hold for our data. Peripheral factors (probably the length-tension relationship rule for skeletal muscles and viscosity of muscle) may be important in this type of action.

The Effect of Social Integration on Outcomes after Major Lower Extremity Amputation

PubMed Central

Hawkins, Alexander T.; Pallangyo, Anthony J.; Herman, Ayesiga M.; Schaumeier, Maria J.; Smith, Ann D.; Hevelone, Nathanael D.; Crandell, David M.; Nguyen, Louis

2016-01-01

Objective Major lower extremity amputation is a common procedure that results in a profound change in a patient's life. We sought to determine the association between social support and outcomes after amputation. We hypothesized that patients with greater social support will have better post amputation outcomes. Methods From November 2011 to May 2013, we conducted a cross-sectional, observational, multicenter study. Social integration was measured by the social integration subset of the Short Form (Craig Handicap Assessment and Reporting Technique (CHART). Systemic social support was assessed by comparing a US and Tanzanian population. Walking function was measured using the 6MWT and quality of life (QoL) was measured using the EQ-5D. Results 102 major lower extremity amputees were recruited. 63 patients were enrolled in the US with a mean age of 58.0. Forty-two (67%) were male. Patients with low social integration were more likely to be unable to ambulate (no walk 39% vs. slow walk 23% vs. fast walk 10%; P=.01) and those with high social integration were more likely to be fast walkers (no walk 10% vs. slow walk 59% vs. fast walk 74%; P=.01). This relationship persisted in a multivariable analysis. Increasing social integration scores were also positively associated with increasing quality of life scores in a multivariable analysis (β .002; SE .0008; P = .02). In comparing the US population with the Tanzanian cohort (39 subjects), there were no significant differences between functional or quality of life outcomes in the systemic social support analysis. Conclusions In the US population, increased social integration is associated with both improved function and quality of life outcomes among major lower extremity amputees. Systemic social support, as measured by comparing the US population with a Tanzanian population, was not associated with improved function or quality of life outcomes. In the US, steps should be taken to identify and aid amputees with poor social integration. PMID:26474508

Large Area Field of View for Fast Temporal Resolution Astronomy

NASA Astrophysics Data System (ADS)

Covarrubias, Ricardo A.

2018-01-01

Scientific CMOS (sCMOS) technology is especially relevant for high temporal resolution astronomy combining high resolution, large field of view with very fast frame rates, without sacrificing ultra-low noise performance. Solar Astronomy, Near Earth Object detections, Space Debris Tracking, Transient Observations or Wavefront Sensing are among the many applications this technology can be utilized. Andor Technology is currently developing the next-generation, very large area sCMOS camera with an extremely low noise, rapid frame rates, high resolution and wide dynamic range.

Enabling fast charging – A battery technology gap assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmed, Shabbir; Bloom, Ira; Jansen, Andrew N.

The battery technology literature is reviewed, with an emphasis on key elements that limit extreme fast charging. Key gaps in existing elements of the technology are presented as well as developmental needs. Among these needs are advanced models and methods to detect and prevent lithium plating; new positive-electrode materials which are less prone to stress-induced failure; better electrode designs to accommodate very rapid diffusion in and out of the electrode; and thermal management and pack designs to accommodate the higher operating voltage.

Enabling fast charging – A battery technology gap assessment

DOE PAGES

Ahmed, Shabbir; Bloom, Ira; Jansen, Andrew N.; ...

2017-10-23

The battery technology literature is reviewed, with an emphasis on key elements that limit extreme fast charging. Key gaps in existing elements of the technology are presented as well as developmental needs. Among these needs are advanced models and methods to detect and prevent lithium plating; new positive-electrode materials which are less prone to stress-induced failure; better electrode designs to accommodate very rapid diffusion in and out of the electrode; and thermal management and pack designs to accommodate the higher operating voltage.

MULTIPLIER CIRCUIT

DOEpatents

Chase, R.L.

1963-05-01

An electronic fast multiplier circuit utilizing a transistor controlled voltage divider network is presented. The multiplier includes a stepped potentiometer in which solid state or transistor switches are substituted for mechanical wipers in order to obtain electronic switching that is extremely fast as compared to the usual servo-driven mechanical wipers. While this multiplier circuit operates as an approximation and in steps to obtain a voltage that is the product of two input voltages, any desired degree of accuracy can be obtained with the proper number of increments and adjustment of parameters. (AEC)

SU-E-J-191: Motion Prediction Using Extreme Learning Machine in Image Guided Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jia, J; Cao, R; Pei, X

Purpose: Real-time motion tracking is a critical issue in image guided radiotherapy due to the time latency caused by image processing and system response. It is of great necessity to fast and accurately predict the future position of the respiratory motion and the tumor location. Methods: The prediction of respiratory position was done based on the positioning and tracking module in ARTS-IGRT system which was developed by FDS Team (www.fds.org.cn). An approach involving with the extreme learning machine (ELM) was adopted to predict the future respiratory position as well as the tumor’s location by training the past trajectories. For themore » training process, a feed-forward neural network with one single hidden layer was used for the learning. First, the number of hidden nodes was figured out for the single layered feed forward network (SLFN). Then the input weights and hidden layer biases of the SLFN were randomly assigned to calculate the hidden neuron output matrix. Finally, the predicted movement were obtained by applying the output weights and compared with the actual movement. Breathing movement acquired from the external infrared markers was used to test the prediction accuracy. And the implanted marker movement for the prostate cancer was used to test the implementation of the tumor motion prediction. Results: The accuracy of the predicted motion and the actual motion was tested. Five volunteers with different breathing patterns were tested. The average prediction time was 0.281s. And the standard deviation of prediction accuracy was 0.002 for the respiratory motion and 0.001 for the tumor motion. Conclusion: The extreme learning machine method can provide an accurate and fast prediction of the respiratory motion and the tumor location and therefore can meet the requirements of real-time tumor-tracking in image guided radiotherapy.« less

Applying Customized Climate Advisory Information to Translate Extreme Rainfall Events into Farming Options in the Sudan-Sahel of West Africa

NASA Astrophysics Data System (ADS)

Salack, S.; Worou, N. O.; Sanfo, S.; Nikiema, M. P.; Boubacar, I.; Paturel, J. E.; Tondoh, E. J.

2017-12-01

In West Africa, the risk of food insecurity linked to the low productivity of small holder farming increases as a result of rainfall extremes. In its recent evolution, the rainy season in the Sudan-Sahel zone presents mixed patterns of extreme climatic events. In addition to intense rain events, the distribution of events is associated with pockets of intra-seasonal long dry spells. The negative consequences of these mixed patterns are obvious on the farm: soil water logging, erosion of arable land, dwartness and dessication of crops, and loss in production. The capacity of local farming communities to respond accordingly to rainfall extreme events is often constrained by lack of access to climate information and advisory on smart crop management practices that can help translate extreme rainfall events into farming options. The objective of this work is to expose the framework and the pre-liminary results of a scheme that customizes climate-advisory information package delivery to subsistence farmers in Bakel (Senegal), Ouahigouya & Dano (Burkina Faso) and Bolgatanga (Ghana) for sustainable family agriculture. The package is based on the provision of timely climate information (48-hours, dekadal & seasonal) embedded with smart crop management practices to explore and exploite the potential advantage of intense rainfall and extreme dry spells in millet, maize, sorghum and cowpea farming communities. It is sent via mobile phones and used on selected farms (i.e agro-climatic farm schools) on which some small on-farm infrastructure were built to alleviate negative impacts of weather. Results provide prominent insight on how co-production of weather/climate information, customized access and guidiance on its use can induce fast learning (capacity building of actors), motivation for adaptation, sustainability, potential changes in cropping system, yields and family income in the face of a rainfall extremes at local scales of Sudan-Sahel of West Africa. Keywords: Climate Information, Smart Practices, Farming Options, Agro-Climatic Farm Schools, Sudan-Sahel

Simulated heat waves affected alpine grassland only in combination with drought.

PubMed

De Boeck, Hans J; Bassin, Seraina; Verlinden, Maya; Zeiter, Michaela; Hiltbrunner, Erika

2016-01-01

The Alpine region is warming fast, and concurrently, the frequency and intensity of climate extremes are increasing. It is currently unclear whether alpine ecosystems are sensitive or resistant to such extremes. We subjected Swiss alpine grassland communities to heat waves with varying intensity by transplanting monoliths to four different elevations (2440-660 m above sea level) for 17 d. Half of these were regularly irrigated while the other half were deprived of irrigation to additionally induce a drought at each site. Heat waves had no significant impacts on fluorescence (Fv /Fm , a stress indicator), senescence and aboveground productivity if irrigation was provided. However, when heat waves coincided with drought, the plants showed clear signs of stress, resulting in vegetation browning and reduced phytomass production. This likely resulted from direct drought effects, but also, as measurements of stomatal conductance and canopy temperatures suggest, from increased high-temperature stress as water scarcity decreased heat mitigation through transpiration. The immediate responses to heat waves (with or without droughts) recorded in these alpine grasslands were similar to those observed in the more extensively studied grasslands from temperate climates. Responses following climate extremes may differ in alpine environments, however, because the short growing season likely constrains recovery. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Fast but not intuitive, slow but not reflective: Decision conflict drives reaction times in social dilemmas.

PubMed

Evans, Anthony M; Dillon, Kyle D; Rand, David G

2015-10-01

When people have the chance to help others at a cost to themselves, are cooperative decisions driven by intuition or reflection? To answer this question, recent studies have tested the relationship between reaction times (RTs) and cooperation, reporting both positive and negative correlations. To reconcile this apparent contradiction, we argue that decision conflict (rather than the use of intuition vs. reflection) drives response times, leading to an inverted-U shaped relationship between RT and cooperation. Studies 1 through 3 show that intermediate decisions take longer than both extremely selfish and extremely cooperative decisions. Studies 4 and 5 find that the conflict between self-interested and cooperative motives explains individual differences in RTs. Manipulating conflictedness causes longer RTs and more intermediate decisions, and RTs mediate the relationship between conflict and intermediate decisions. Finally, Studies 6 and 7 demonstrate that conflict is distinct from reflection by manipulating the use of intuition (vs. reflection). Experimentally promoting reliance on intuition increases cooperation, but has no effects on decision extremity or feelings of conflictedness. In sum, we provide evidence that RTs should not be interpreted as a direct proxy for the use of intuitive or reflective processes, and dissociate the effects of conflict and reflection in social decision making. (c) 2015 APA, all rights reserved).

Microplate-Based Method for High-Throughput Screening (HTS) of Chromatographic Conditions Studies for Recombinant Protein Purification.

PubMed

Carvalho, Rimenys J; Cruz, Thayana A

2018-01-01

High-throughput screening (HTS) systems have emerged as important tools to provide fast and low cost evaluation of several conditions at once since it requires small quantities of material and sample volumes. These characteristics are extremely valuable for experiments with large number of variables enabling the application of design of experiments (DoE) strategies or simple experimental planning approaches. Once, the capacity of HTS systems to mimic chromatographic purification steps was established, several studies were performed successfully including scale down purification. Here, we propose a method for studying different purification conditions that can be used for any recombinant protein, including complex and glycosylated proteins, using low binding filter microplates.

Uniform semiclassical sudden approximation for rotationally inelastic scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korsch, H.J.; Schinke, R.

1980-08-01

The infinite-order-sudden (IOS) approximation is investigated in the semiclassical limit. A simplified IOS formula for rotationally inelastic differential cross sections is derived involving a uniform stationary phase approximation for two-dimensional oscillatory integrals with two stationary points. The semiclassical analysis provides a quantitative description of the rotational rainbow structure in the differential cross section. The numerical calculation of semiclassical IOS cross sections is extremely fast compared to numerically exact IOS methods, especially if high ..delta..j transitions are involved. Rigid rotor results for He--Na/sub 2/ collisions with ..delta..j< or approx. =26 and for K--CO collisions with ..delta..j< or approx. =70 show satisfactorymore » agreement with quantal IOS calculations.« less

Ultrafast photodimerization dynamics in α-cyano-4-hydroxycinnamic and sinapinic acid crystals

NASA Astrophysics Data System (ADS)

Hoyer, Theo; Tuszynski, Wilfried; Lienau, Christoph

2007-07-01

We report a sub-picosecond time-resolved fluorescence spectroscopic study of different cinnamic acid crystals, model systems for solid-state photodimerization reactions. For α-cyano-4-hydroxycinnamic acid (α-CHC), we identify the emission spectra of both monomers and dimers, allowing us to directly probe the photoinduced dynamics of both species. The dimerization occurs on a timescale of 10 ps and results in a long-lived dimer product, stable for hours. For sinapinic acid, we find an extremely fast, sub-picosecond dimerization reaction and a short-lived dimer. This first sub-picosecond time-resolved dimerization study in cinnamic acid crystals provides a new basis for relating their structural properties and microscopic reaction dynamics.

Non-destructive determination of Malondialdehyde (MDA) distribution in oilseed rape leaves by laboratory scale NIR hyperspectral imaging

NASA Astrophysics Data System (ADS)

Kong, Wenwen; Liu, Fei; Zhang, Chu; Zhang, Jianfeng; Feng, Hailin

2016-10-01

The feasibility of hyperspectral imaging with 400-1000 nm was investigated to detect malondialdehyde (MDA) content in oilseed rape leaves under herbicide stress. After comparing the performance of different preprocessing methods, linear and nonlinear calibration models, the optimal prediction performance was achieved by extreme learning machine (ELM) model with only 23 wavelengths selected by competitive adaptive reweighted sampling (CARS), and the result was RP = 0.929 and RMSEP = 2.951. Furthermore, MDA distribution map was successfully achieved by partial least squares (PLS) model with CARS. This study indicated that hyperspectral imaging technology provided a fast and nondestructive solution for MDA content detection in plant leaves.

Wedge sampling for computing clustering coefficients and triangle counts on large graphs

DOE PAGES

Seshadhri, C.; Pinar, Ali; Kolda, Tamara G.

2014-05-08

Graphs are used to model interactions in a variety of contexts, and there is a growing need to quickly assess the structure of such graphs. Some of the most useful graph metrics are based on triangles, such as those measuring social cohesion. Despite the importance of these triadic measures, algorithms to compute them can be extremely expensive. We discuss the method of wedge sampling. This versatile technique allows for the fast and accurate approximation of various types of clustering coefficients and triangle counts. Furthermore, these techniques are extensible to counting directed triangles in digraphs. Our methods come with provable andmore » practical time-approximation tradeoffs for all computations. We provide extensive results that show our methods are orders of magnitude faster than the state of the art, while providing nearly the accuracy of full enumeration.« less

Perspectives of voltage control for magnetic exchange bias in multiferroic heterostructures

NASA Astrophysics Data System (ADS)

Yang, Q.; Zhou, Z.; Sun, N. X.; Liu, M.

2017-04-01

Exchange bias, as an internal magnetic bias induced by a ferromagnetic-antiferromagnetic exchange coupling, is extremely important in many magnetic applications such as memories, sensors and other devices. Voltage control of exchange bias in multiferroics provides an energy-efficient way to achieve a rapidly 180° deterministic switching of magnetization, which has been considered as a key challenge in realizing next generation of fast, compact and ultra-low power magnetoelectric memories and sensors. Additionally, exchange bias can enhance dynamic magnetoelectric coupling strength in an external-field-free manner. In this paper, we provide a perspective on voltage control of exchange bias in different multiferroic heterostructures. Brief mechanization and related experiments are discussed as well as future trend and challenges that can be overcome by electrically tuning of exchange bias in state-of-the-art magnetoelectric devices.

SLOW PATCHY EXTREME-ULTRAVIOLET PROPAGATING FRONTS ASSOCIATED WITH FAST CORONAL MAGNETO-ACOUSTIC WAVES IN SOLAR ERUPTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Y.; Ding, M. D.; Chen, P. F., E-mail: guoyang@nju.edu.cn

2015-08-15

Using the high spatiotemporal resolution extreme ultraviolet (EUV) observations of the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory, we conduct a statistical study of the observational properties of the coronal EUV propagating fronts. We find that it might be a universal phenomenon for two types of fronts to coexist in a large solar eruptive event. It is consistent with the hybrid model of EUV propagating fronts, which predicts that coronal EUV propagating fronts consist of both a fast magneto-acoustic wave and a nonwave component. We find that the morphologies, propagation behaviors, and kinematic features of the two EUVmore » propagating fronts are completely different from each other. The fast magneto-acoustic wave fronts are almost isotropic. They travel continuously from the flaring region across multiple magnetic polarities to global distances. On the other hand, the slow nonwave fronts appear as anisotropic and sequential patches of EUV brightening. Each patch propagates locally in the magnetic domains where the magnetic field lines connect to the bottom boundary and stops at the magnetic domain boundaries. Within each magnetic domain, the velocities of the slow patchy nonwave component are an order of magnitude lower than that of the fast-wave component. However, the patches of the slow EUV propagating front can jump from one magnetic domain to a remote one. The velocities of such a transit between different magnetic domains are about one-third to one-half of those of the fast-wave component. The results show that the velocities of the nonwave component, both within one magnetic domain and between different magnetic domains, are highly nonuniform due to the inhomogeneity of the magnetic field in the lower atmosphere.« less

The impact of inter-annual rainfall variability on African savannas changes with mean rainfall.

PubMed

Synodinos, Alexis D; Tietjen, Britta; Lohmann, Dirk; Jeltsch, Florian

2018-01-21

Savannas are mixed tree-grass ecosystems whose dynamics are predominantly regulated by resource competition and the temporal variability in climatic and environmental factors such as rainfall and fire. Hence, increasing inter-annual rainfall variability due to climate change could have a significant impact on savannas. To investigate this, we used an ecohydrological model of stochastic differential equations and simulated African savanna dynamics along a gradient of mean annual rainfall (520-780 mm/year) for a range of inter-annual rainfall variabilities. Our simulations produced alternative states of grassland and savanna across the mean rainfall gradient. Increasing inter-annual variability had a negative effect on the savanna state under dry conditions (520 mm/year), and a positive effect under moister conditions (580-780 mm/year). The former resulted from the net negative effect of dry and wet extremes on trees. In semi-arid conditions (520 mm/year), dry extremes caused a loss of tree cover, which could not be recovered during wet extremes because of strong resource competition and the increased frequency of fires. At high mean rainfall (780 mm/year), increased variability enhanced savanna resilience. Here, resources were no longer limiting and the slow tree dynamics buffered against variability by maintaining a stable population during 'dry' extremes, providing the basis for growth during wet extremes. Simultaneously, high rainfall years had a weak marginal benefit on grass cover due to density-regulation and grazing. Our results suggest that the effects of the slow tree and fast grass dynamics on tree-grass interactions will become a major determinant of the savanna vegetation composition with increasing rainfall variability. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Clinically Relevant Method of Analyzing Continuous Change in Robotic Upper Extremity Chronic Stroke Rehabilitation.

PubMed

Massie, Crystal L; Du, Yue; Conroy, Susan S; Krebs, H Igo; Wittenberg, George F; Bever, Christopher T; Whitall, Jill

2016-09-01

Robots designed for rehabilitation of the upper extremity after stroke facilitate high rates of repetition during practice of movements and record precise kinematic data, providing a method to investigate motor recovery profiles over time. To determine how motor recovery profiles during robotic interventions provide insight into improving clinical gains. A convenience sample (n = 22), from a larger randomized control trial, was taken of chronic stroke participants completing 12 sessions of arm therapy. One group received 60 minutes of robotic therapy (Robot only) and the other group received 45 minutes on the robot plus 15 minutes of translation-to-task practice (Robot + TTT). Movement time was assessed using the robot without powered assistance. Analyses (ANOVA, random coefficient modeling [RCM] with 2-term exponential function) were completed to investigate changes across the intervention, between sessions, and within a session. Significant improvement (P < .05) in movement time across the intervention (pre vs post) was similar between the groups but there were group differences for changes between and within sessions (P < .05). The 2-term exponential function revealed a fast and slow component of learning that described performance across consecutive blocks. The RCM identified individuals who were above or below the marginal model. The expanded analyses indicated that changes across time can occur in different ways but achieve similar goals and may be influenced by individual factors such as initial movement time. These findings will guide decisions regarding treatment planning based on rates of motor relearning during upper extremity stroke robotic interventions. © The Author(s) 2015.

Fast and stable redox reactions of MnO2/CNT hybrid electrodes for dynamically stretchable pseudocapacitors

NASA Astrophysics Data System (ADS)

Gu, Taoli; Wei, Bingqing

2015-07-01

Pseudocapacitors, which are energy storage devices that take advantage of redox reactions to store electricity, have a different charge storage mechanism compared to lithium-ion batteries (LIBs) and electric double-layer capacitors (EDLCs), and they could realize further gains if they were used as stretchable power sources. The realization of dynamically stretchable pseudocapacitors and understanding of the underlying fundamentals of their mechanical-electrochemical relationship have become indispensable. We report herein the electrochemical performance of dynamically stretchable pseudocapacitors using buckled MnO2/CNT hybrid electrodes. The extremely small relaxation time constant of less than 0.15 s indicates a fast redox reaction at the MnO2/CNT hybrid electrodes, securing a stable electrochemical performance for the dynamically stretchable pseudocapacitors. This finding and the fundamental understanding gained from the pseudo-capacitive behavior coupled with mechanical deformation under a dynamic stretching mode would provide guidance to further improve their overall performance including a higher power density than LIBs, a higher energy density than EDLCs, and a long-life cycling stability. Most importantly, these results will potentially accelerate the applications of stretchable pseudocapacitors for flexible and biomedical electronics.Pseudocapacitors, which are energy storage devices that take advantage of redox reactions to store electricity, have a different charge storage mechanism compared to lithium-ion batteries (LIBs) and electric double-layer capacitors (EDLCs), and they could realize further gains if they were used as stretchable power sources. The realization of dynamically stretchable pseudocapacitors and understanding of the underlying fundamentals of their mechanical-electrochemical relationship have become indispensable. We report herein the electrochemical performance of dynamically stretchable pseudocapacitors using buckled MnO2/CNT hybrid electrodes. The extremely small relaxation time constant of less than 0.15 s indicates a fast redox reaction at the MnO2/CNT hybrid electrodes, securing a stable electrochemical performance for the dynamically stretchable pseudocapacitors. This finding and the fundamental understanding gained from the pseudo-capacitive behavior coupled with mechanical deformation under a dynamic stretching mode would provide guidance to further improve their overall performance including a higher power density than LIBs, a higher energy density than EDLCs, and a long-life cycling stability. Most importantly, these results will potentially accelerate the applications of stretchable pseudocapacitors for flexible and biomedical electronics. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr02310f

Demonstrating the Value of Near Real-time Satellite-based Earth Observations in a Research and Education Framework

NASA Astrophysics Data System (ADS)

Chiu, L.; Hao, X.; Kinter, J. L.; Stearn, G.; Aliani, M.

2017-12-01

The launch of GOES-16 series provides an opportunity to advance near real-time applications in natural hazard detection, monitoring and warning. This study demonstrates the capability and values of receiving real-time satellite-based Earth observations over a fast terrestrial networks and processing high-resolution remote sensing data in a university environment. The demonstration system includes 4 components: 1) Near real-time data receiving and processing; 2) data analysis and visualization; 3) event detection and monitoring; and 4) information dissemination. Various tools are developed and integrated to receive and process GRB data in near real-time, produce images and value-added data products, and detect and monitor extreme weather events such as hurricane, fire, flooding, fog, lightning, etc. A web-based application system is developed to disseminate near-real satellite images and data products. The images are generated with GIS-compatible format (GeoTIFF) to enable convenient use and integration in various GIS platforms. This study enhances the capacities for undergraduate and graduate education in Earth system and climate sciences, and related applications to understand the basic principles and technology in real-time applications with remote sensing measurements. It also provides an integrated platform for near real-time monitoring of extreme weather events, which are helpful for various user communities.

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom.

PubMed

Stenvinkel, Peter; Painer, Johanna; Kuro-O, Makoto; Lanaspa, Miguel; Arnold, Walter; Ruf, Thomas; Shiels, Paul G; Johnson, Richard J

2018-04-01

Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress. Biomimetic studies suggest that the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) offers protection in extreme environmental conditions and promotes longevity in the animal kingdom. Similarly, during months of fasting, immobilization and anuria, hibernating bears are protected from muscle wasting, azotaemia, thrombotic complications, organ damage and osteoporosis - features that are often associated with CKD. Improved understanding of the susceptibility and protective mechanisms of these animals and others could provide insights into novel strategies to prevent and treat several human diseases, such as CKD and ageing-associated complications. An integrated collaboration between nephrologists and experts from other fields, such as veterinarians, zoologists, biologists, anthropologists and ecologists, could introduce a novel approach for improving human health and help nephrologists to find novel treatment strategies for CKD.

Accurate evaluation of fast threshold voltage shift for SiC MOS devices under various gate bias stress conditions

NASA Astrophysics Data System (ADS)

Sometani, Mitsuru; Okamoto, Mitsuo; Hatakeyama, Tetsuo; Iwahashi, Yohei; Hayashi, Mariko; Okamoto, Dai; Yano, Hiroshi; Harada, Shinsuke; Yonezawa, Yoshiyuki; Okumura, Hajime

2018-04-01

We investigated methods of measuring the threshold voltage (V th) shift of 4H-silicon carbide (SiC) metal–oxide–semiconductor field-effect transistors (MOSFETs) under positive DC, negative DC, and AC gate bias stresses. A fast measurement method for V th shift under both positive and negative DC stresses revealed the existence of an extremely large V th shift in the short-stress-time region. We then examined the effect of fast V th shifts on drain current (I d) changes within a pulse under AC operation. The fast V th shifts were suppressed by nitridation. However, the I d change within one pulse occurred even in commercially available SiC MOSFETs. The correlation between I d changes within one pulse and V th shifts measured by a conventional method is weak. Thus, a fast and in situ measurement method is indispensable for the accurate evaluation of I d changes under AC operation.

Advanced Ultrasonic Diagnosis of Extremity Trauma: The Faster Exam

NASA Technical Reports Server (NTRS)

Dulchavsky, S. A.; Henry, S. E.; Moed, B. R.; Diebel, L. N.; Marshburn, T.; Hamilton, D. R.; Logan, J.; Kirkpatrick, A. W.; Williams, D. R.

2002-01-01

Ultrasound is of prO)len accuracy in abdominal and thoracic trauma and may be useful to diagnose extremity injury in situations where radiography is not available such as military and space applications. We prospectively evaluated the utility of extremity , ultrasound performed by trained, non-physician personnel in patients with extremity trauma, to simulate remote aerospace or military applications . Methods: Patients with extremity trauma were identified by history, physical examination, and radiographic studies. Ultrasound examination was performed bilaterally by nonphysician personnel with a portable ultrasound device using a 10-5 MHz linear probe, Images were video-recorded for later analysis against radiography by Fisher's exact test. The average time of examination was 4 minutes. Ultrasound accurately diagnosed extremity, injury in 94% of patients with no false positive exams; accuracy was greater in mid-shaft locations and least in the metacarpa/metatarsals. Soft tissue/tendon injury was readily visualized . Extremity ultrasound can be performed quickly and accurately by nonphysician personnel with excellent accuracy. Blinded verification of the utility of ultrasound in patients with extremity injury should be done to determine if Extremity and Respiratory evaluation should be added to the FAST examination (the FASTER exam) and verify the technique in remote locations such as military and aerospace applications.

Whisker Contact Detection of Rodents Based on Slow and Fast Mechanical Inputs

PubMed Central

Claverie, Laure N.; Boubenec, Yves; Debrégeas, Georges; Prevost, Alexis M.; Wandersman, Elie

2017-01-01

Rodents use their whiskers to locate nearby objects with an extreme precision. To perform such tasks, they need to detect whisker/object contacts with a high temporal accuracy. This contact detection is conveyed by classes of mechanoreceptors whose neural activity is sensitive to either slow or fast time varying mechanical stresses acting at the base of the whiskers. We developed a biomimetic approach to separate and characterize slow quasi-static and fast vibrational stress signals acting on a whisker base in realistic exploratory phases, using experiments on both real and artificial whiskers. Both slow and fast mechanical inputs are successfully captured using a mechanical model of the whisker. We present and discuss consequences of the whisking process in purely mechanical terms and hypothesize that free whisking in air sets a mechanical threshold for contact detection. The time resolution and robustness of the contact detection strategies based on either slow or fast stress signals are determined. Contact detection based on the vibrational signal is faster and more robust to exploratory conditions than the slow quasi-static component, although both slow/fast components allow localizing the object. PMID:28119582

Micro-optical fabrication by ultraprecision diamond machining and precision molding

NASA Astrophysics Data System (ADS)

Li, Hui; Li, Likai; Naples, Neil J.; Roblee, Jeffrey W.; Yi, Allen Y.

2017-06-01

Ultraprecision diamond machining and high volume molding for affordable high precision high performance optical elements are becoming a viable process in optical industry for low cost high quality microoptical component manufacturing. In this process, first high precision microoptical molds are fabricated using ultraprecision single point diamond machining followed by high volume production methods such as compression or injection molding. In the last two decades, there have been steady improvements in ultraprecision machine design and performance, particularly with the introduction of both slow tool and fast tool servo. Today optical molds, including freeform surfaces and microlens arrays, are routinely diamond machined to final finish without post machining polishing. For consumers, compression molding or injection molding provide efficient and high quality optics at extremely low cost. In this paper, first ultraprecision machine design and machining processes such as slow tool and fast too servo are described then both compression molding and injection molding of polymer optics are discussed. To implement precision optical manufacturing by molding, numerical modeling can be included in the future as a critical part of the manufacturing process to ensure high product quality.

A fast and complete GEANT4 and ROOT Object-Oriented Toolkit: GROOT

NASA Astrophysics Data System (ADS)

Lattuada, D.; Balabanski, D. L.; Chesnevskaya, S.; Costa, M.; Crucillà, V.; Guardo, G. L.; La Cognata, M.; Matei, C.; Pizzone, R. G.; Romano, S.; Spitaleri, C.; Tumino, A.; Xu, Y.

2018-01-01

Present and future gamma-beam facilities represent a great opportunity to validate and evaluate the cross-sections of many photonuclear reactions at near-threshold energies. Monte Carlo (MC) simulations are very important to evaluate the reaction rates and to maximize the detection efficiency but, unfortunately, they can be very cputime-consuming and in some cases very hard to reproduce, especially when exploring near-threshold cross-section. We developed a software that makes use of the validated tracking GEANT4 libraries and the n-body event generator of ROOT in order to provide a fast, realiable and complete MC tool to be used for nuclear physics experiments. This tool is indeed intended to be used for photonuclear reactions at γ-beam facilities with ELISSA (ELI Silicon Strip Array), a new detector array under development at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP). We discuss the results of MC simulations performed to evaluate the effects of the electromagnetic induced background, of the straggling due to the target thickness and of the resolution of the silicon detectors.

Mixed matrix membranes with fast and selective transport pathways for efficient CO2 separation

NASA Astrophysics Data System (ADS)

Hou, Jinpeng; Li, Xueqin; Guo, Ruili; Zhang, Jianshu; Wang, Zhongming

2018-03-01

To improve CO2 separation performance, porous carbon nanosheets (PCNs) were used as a filler into a Pebax MH 1657 (Pebax) matrix, fabricating mixed matrix membranes (MMMs). The PCNs exhibited a preferential horizontal orientation within the Pebax matrix because of the extremely large 2D plane and nanoscale thickness of the matrix. Therefore, the micropores of the PCNs provided fast CO2 transport pathways, which led to increased CO2 permeability. The reduced pore size of the PCNs was a consequence of the overlapping of PCNs and the polymer chains penetrating into the pores of the PCNs. The reduction in the pore size of the PCNs improved the CO2/gas selectivity. As a result, the CO2 permeability and CO2/CH4 selectivity of the Pebax membrane with 10 wt% PCNs-loading (Pebax-PCNs-10) were 520 barrer and 51, respectively, for CO2/CH4 mixed-gas. The CO2 permeability and CO2/N2 selectivity of the Pebax-PCNs-10 membrane were 614 barrer and 61, respectively, for CO2/N2 mixed-gas.

Fast approach for toner saving

NASA Astrophysics Data System (ADS)

Safonov, Ilia V.; Kurilin, Ilya V.; Rychagov, Michael N.; Lee, Hokeun; Kim, Sangho; Choi, Donchul

2011-01-01

Reducing toner consumption is an important task in modern printing devices and has a significant positive ecological impact. Existing toner saving approaches have two main drawbacks: appearance of hardcopy in toner saving mode is worse in comparison with normal mode; processing of whole rendered page bitmap requires significant computational costs. We propose to add small holes of various shapes and sizes to random places inside a character bitmap stored in font cache. Such random perforation scheme is based on processing pipeline in RIP of standard printer languages Postscript and PCL. Processing of text characters only, and moreover, processing of each character for given font and size alone, is an extremely fast procedure. The approach does not deteriorate halftoned bitmap and business graphics and provide toner saving for typical office documents up to 15-20%. Rate of toner saving is adjustable. Alteration of resulted characters' appearance is almost indistinguishable in comparison with solid black text due to random placement of small holes inside the character regions. The suggested method automatically skips small fonts to preserve its quality. Readability of text processed by proposed method is fine. OCR programs process that scanned hardcopy successfully too.

Pionic Fusion of 4He +12 C

NASA Astrophysics Data System (ADS)

Zarrella, Andrew; Yennello, Sherry

2017-09-01

Pionic fusion is the process by which two nuclei fuse and then deexcite by the exclusive emission of a pion. These reactions represent the most extreme examples of deep subthreshold pion production and provide evidence for an unknown, collective mechanism for pion production. An experiment was performed at the Texas A&M University Cyclotron Institute to measure the cross section of the 4He +12 C -> 16N +π+ reaction. The Momentum Achromat Recoil Spectrometer (MARS) was used to separate and identify the 16N fusion residues and the newly constructed Partial Truncated Icosahedron (ParTI) phoswich array was used to identify charged pions. The detector responses for each phoswich unit were recorded using fast-sampling ADCs which allow all light charged particles in the ParTI phoswiches to be identified using ``fast vs. slow'' pulse shape discrimination. By writing the waveform responses, pions can also be identified by the presence of a characteristic muon decay pulse. The combination of the residue-pion coincidence and the two independent pion identification techniques represent a highly sensitive experimental design for studying pionic fusion reactions.

A Fast SVD-Hidden-nodes based Extreme Learning Machine for Large-Scale Data Analytics.

PubMed

Deng, Wan-Yu; Bai, Zuo; Huang, Guang-Bin; Zheng, Qing-Hua

2016-05-01

Big dimensional data is a growing trend that is emerging in many real world contexts, extending from web mining, gene expression analysis, protein-protein interaction to high-frequency financial data. Nowadays, there is a growing consensus that the increasing dimensionality poses impeding effects on the performances of classifiers, which is termed as the "peaking phenomenon" in the field of machine intelligence. To address the issue, dimensionality reduction is commonly employed as a preprocessing step on the Big dimensional data before building the classifiers. In this paper, we propose an Extreme Learning Machine (ELM) approach for large-scale data analytic. In contrast to existing approaches, we embed hidden nodes that are designed using singular value decomposition (SVD) into the classical ELM. These SVD nodes in the hidden layer are shown to capture the underlying characteristics of the Big dimensional data well, exhibiting excellent generalization performances. The drawback of using SVD on the entire dataset, however, is the high computational complexity involved. To address this, a fast divide and conquer approximation scheme is introduced to maintain computational tractability on high volume data. The resultant algorithm proposed is labeled here as Fast Singular Value Decomposition-Hidden-nodes based Extreme Learning Machine or FSVD-H-ELM in short. In FSVD-H-ELM, instead of identifying the SVD hidden nodes directly from the entire dataset, SVD hidden nodes are derived from multiple random subsets of data sampled from the original dataset. Comprehensive experiments and comparisons are conducted to assess the FSVD-H-ELM against other state-of-the-art algorithms. The results obtained demonstrated the superior generalization performance and efficiency of the FSVD-H-ELM. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ear Deformations Give Bats a Physical Mechanism for Fast Adaptation of Ultrasonic Beam Patterns

NASA Astrophysics Data System (ADS)

Gao, Li; Balakrishnan, Sreenath; He, Weikai; Yan, Zhen; Müller, Rolf

2011-11-01

A large number of mammals, including humans, have intricate outer ear shapes that diffract incoming sound in a direction- and frequency-specific manner. Through this physical process, the outer ear shapes encode sound-source information into the sensory signals from each ear. Our results show that horseshoe bats could dynamically control these diffraction processes through fast nonrigid ear deformations. The bats’ ear shapes can alter between extreme configurations in about 100 ms and thereby change their acoustic properties in ways that would suit different acoustic sensing tasks.

Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: measurements and model predictions.

PubMed

Talih, Soha; Balhas, Zainab; Eissenberg, Thomas; Salman, Rola; Karaoghlanian, Nareg; El Hellani, Ahmad; Baalbaki, Rima; Saliba, Najat; Shihadeh, Alan

2015-02-01

Some electronic cigarette (ECIG) users attain tobacco cigarette-like plasma nicotine concentrations while others do not. Understanding the factors that influence ECIG aerosol nicotine delivery is relevant to regulation, including product labeling and abuse liability. These factors may include user puff topography, ECIG liquid composition, and ECIG design features. This study addresses how these factors can influence ECIG nicotine yield. Aerosols were machine generated with 1 type of ECIG cartridge (V4L CoolCart) using 5 distinct puff profiles representing a tobacco cigarette smoker (2-s puff duration, 33-ml/s puff velocity), a slow average ECIG user (4 s, 17 ml/s), a fast average user (4 s, 33 ml/s), a slow extreme user (8 s, 17 ml/s), and a fast extreme user (8 s, 33 ml/s). Output voltage (3.3-5.2 V or 3.0-7.5 W) and e-liquid nicotine concentration (18-36 mg/ml labeled concentration) were varied. A theoretical model was also developed to simulate the ECIG aerosol production process and to provide insight into the empirical observations. Nicotine yields from 15 puffs varied by more than 50-fold across conditions. Experienced ECIG user profiles (longer puffs) resulted in higher nicotine yields relative to the tobacco smoker (shorter puffs). Puff velocity had no effect on nicotine yield. Higher nicotine concentration and higher voltages resulted in higher nicotine yields. These results were predicted well by the theoretical model (R (2) = 0.99). Depending on puff conditions and product features, 15 puffs from an ECIG can provide far less or far more nicotine than a single tobacco cigarette. ECIG emissions can be predicted using physical principles, with knowledge of puff topography and a few ECIG device design parameters. © The Author 2014. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Effects of User Puff Topography, Device Voltage, and Liquid Nicotine Concentration on Electronic Cigarette Nicotine Yield: Measurements and Model Predictions

PubMed Central

Talih, Soha; Balhas, Zainab; Eissenberg, Thomas; Salman, Rola; Karaoghlanian, Nareg; El Hellani, Ahmad; Baalbaki, Rima; Saliba, Najat

2015-01-01

Introduction: Some electronic cigarette (ECIG) users attain tobacco cigarette–like plasma nicotine concentrations while others do not. Understanding the factors that influence ECIG aerosol nicotine delivery is relevant to regulation, including product labeling and abuse liability. These factors may include user puff topography, ECIG liquid composition, and ECIG design features. This study addresses how these factors can influence ECIG nicotine yield. Methods: Aerosols were machine generated with 1 type of ECIG cartridge (V4L CoolCart) using 5 distinct puff profiles representing a tobacco cigarette smoker (2-s puff duration, 33-ml/s puff velocity), a slow average ECIG user (4 s, 17 ml/s), a fast average user (4 s, 33 ml/s), a slow extreme user (8 s, 17 ml/s), and a fast extreme user (8 s, 33 ml/s). Output voltage (3.3–5.2 V or 3.0–7.5 W) and e-liquid nicotine concentration (18–36 mg/ml labeled concentration) were varied. A theoretical model was also developed to simulate the ECIG aerosol production process and to provide insight into the empirical observations. Results: Nicotine yields from 15 puffs varied by more than 50-fold across conditions. Experienced ECIG user profiles (longer puffs) resulted in higher nicotine yields relative to the tobacco smoker (shorter puffs). Puff velocity had no effect on nicotine yield. Higher nicotine concentration and higher voltages resulted in higher nicotine yields. These results were predicted well by the theoretical model (R 2 = 0.99). Conclusions: Depending on puff conditions and product features, 15 puffs from an ECIG can provide far less or far more nicotine than a single tobacco cigarette. ECIG emissions can be predicted using physical principles, with knowledge of puff topography and a few ECIG device design parameters. PMID:25187061

The fastest disk wind in APM 08279+5255 and its acceleration mechanism

NASA Astrophysics Data System (ADS)

Hagino, K.; Done, C.; Odaka, H.; Watanabe, S.; Takahashi, T.

2017-10-01

The luminous high-z quasar APM 08279+5255 has the most powerful ultra-fast outflow (UFO), which is claimed as the fastest disk wind with velocity of 0.7c. This extreme velocity is very important for constraining the physical mechanism to launch the UFOs because only magnetic driving mechanism can accelerate the winds up to velocities above 0.3c, at which radiation drag effects prevent radiation driving. We reanalyze all the observed data of this source with our spectral model of highly ionized disk winds constructed by 3D Monte Carlo radiation transfer simulation. This was applied to an archetypal disk wind in PDS 456, and successfully reproduced all the spectra observed with Suzaku in spite of their strong spectral variability. By applying our spectral model to APM 08279+5255, all the spectra observed with XMM-Newton, Chandra and Suzaku are explained with less extreme outflow velocities of 0.1-0.2c. In our analysis, the high energy absorption features, which were previously interpreted as absorption lines with extremely fast velocities, are produced by iron-K absorption edges from moderately ionized clumps embedded in the highly ionized wind. We also investigate the broadband SED, and find that it is X-ray weak and UV bright, which prefers the radiation driving.

Performance Study of the First 2D Prototype of Vertically Integrated Pattern Recognition Associative Memory (VIPRAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deptuch, Gregory; Hoff, James; Jindariani, Sergo

Extremely fast pattern recognition capabilities are necessary to find and fit billions of tracks at the hardware trigger level produced every second anticipated at high luminosity LHC (HL-LHC) running conditions. Associative Memory (AM) based approaches for fast pattern recognition have been proposed as a potential solution to the tracking trigger. However, at the HL-LHC, there is much less time available and speed performance must be improved over previous systems while maintaining a comparable number of patterns. The Vertically Integrated Pattern Recognition Associative Memory (VIPRAM) Project aims to achieve the target pattern density and performance goal using 3DIC technology. The firstmore » step taken in the VIPRAM work was the development of a 2D prototype (protoVIPRAM00) in which the associative memory building blocks were designed to be compatible with the 3D integration. In this paper, we present the results from extensive performance studies of the protoVIPRAM00 chip in both realistic HL-LHC and extreme conditions. Results indicate that the chip operates at the design frequency of 100 MHz with perfect correctness in realistic conditions and conclude that the building blocks are ready for 3D stacking. We also present performance boundary characterization of the chip under extreme conditions.« less

Mercury Toolset for Spatiotemporal Metadata

NASA Technical Reports Server (NTRS)

Wilson, Bruce E.; Palanisamy, Giri; Devarakonda, Ranjeet; Rhyne, B. Timothy; Lindsley, Chris; Green, James

2010-01-01

Mercury (http://mercury.ornl.gov) is a set of tools for federated harvesting, searching, and retrieving metadata, particularly spatiotemporal metadata. Version 3.0 of the Mercury toolset provides orders of magnitude improvements in search speed, support for additional metadata formats, integration with Google Maps for spatial queries, facetted type search, support for RSS (Really Simple Syndication) delivery of search results, and enhanced customization to meet the needs of the multiple projects that use Mercury. It provides a single portal to very quickly search for data and information contained in disparate data management systems, each of which may use different metadata formats. Mercury harvests metadata and key data from contributing project servers distributed around the world and builds a centralized index. The search interfaces then allow the users to perform a variety of fielded, spatial, and temporal searches across these metadata sources. This centralized repository of metadata with distributed data sources provides extremely fast search results to the user, while allowing data providers to advertise the availability of their data and maintain complete control and ownership of that data. Mercury periodically (typically daily) harvests metadata sources through a collection of interfaces and re-indexes these metadata to provide extremely rapid search capabilities, even over collections with tens of millions of metadata records. A number of both graphical and application interfaces have been constructed within Mercury, to enable both human users and other computer programs to perform queries. Mercury was also designed to support multiple different projects, so that the particular fields that can be queried and used with search filters are easy to configure for each different project.

Mercury Toolset for Spatiotemporal Metadata

NASA Astrophysics Data System (ADS)

Devarakonda, Ranjeet; Palanisamy, Giri; Green, James; Wilson, Bruce; Rhyne, B. Timothy; Lindsley, Chris

2010-06-01

Mercury (http://mercury.ornl.gov) is a set of tools for federated harvesting, searching, and retrieving metadata, particularly spatiotemporal metadata. Version 3.0 of the Mercury toolset provides orders of magnitude improvements in search speed, support for additional metadata formats, integration with Google Maps for spatial queries, facetted type search, support for RSS (Really Simple Syndication) delivery of search results, and enhanced customization to meet the needs of the multiple projects that use Mercury. It provides a single portal to very quickly search for data and information contained in disparate data management systems, each of which may use different metadata formats. Mercury harvests metadata and key data from contributing project servers distributed around the world and builds a centralized index. The search interfaces then allow the users to perform a variety of fielded, spatial, and temporal searches across these metadata sources. This centralized repository of metadata with distributed data sources provides extremely fast search results to the user, while allowing data providers to advertise the availability of their data and maintain complete control and ownership of that data. Mercury periodically (typically daily)harvests metadata sources through a collection of interfaces and re-indexes these metadata to provide extremely rapid search capabilities, even over collections with tens of millions of metadata records. A number of both graphical and application interfaces have been constructed within Mercury, to enable both human users and other computer programs to perform queries. Mercury was also designed to support multiple different projects, so that the particular fields that can be queried and used with search filters are easy to configure for each different project.

FAST TRACK COMMUNICATION: Inhomogeneous charge redistribution in Xe clusters exposed to an intense extreme ultraviolet free electron laser

NASA Astrophysics Data System (ADS)

Iwayama, H.; Sugishima, A.; Nagaya, K.; Yao, M.; Fukuzawa, H.; Motomura, K.; Liu, X.-J.; Yamada, A.; Wang, C.; Ueda, K.; Saito, N.; Nagasono, M.; Tono, K.; Yabashi, M.; Ishikawa, T.; Ohashi, H.; Kimura, H.; Togashi, T.

2010-08-01

The emission of highly charged ions from Xe clusters exposed to intense extreme ultraviolet laser pulses (λ ~ 52 nm) from the free electron laser in Japan was investigated using ion momentum spectroscopy. With increasing average cluster size, we observed multiply charged ions Xez + up to z = 3. From kinetic energy distributions, we found that multiply charged ions were generated near the cluster surface. Our results suggest that charges are inhomogeneously redistributed in the cluster to lower the total energy stored in the clusters.

The whistle and the rattle: the design of sound producing muscles.

PubMed Central

Rome, L C; Syme, D A; Hollingworth, S; Lindstedt, S L; Baylor, S M

1996-01-01

Vertebrate sound producing muscles often operate at frequencies exceeding 100 Hz, making them the fastest vertebrate muscles. Like other vertebrate muscle, these sonic muscles are "synchronous," necessitating that calcium be released and resequestered by the sarcoplasmic reticulum during each contraction cycle. Thus to operate at such high frequencies, vertebrate sonic muscles require extreme adaptations. We have found that to generate the "boatwhistle" mating call (approximately 200 Hz), the swimbladder muscle fibers of toadfish have evolved (i) a large and very fast calcium transient, (ii) a fast crossbridge detachment rate, and (iii) probably a fast kinetic off-rate of Ca2+ from troponin. The fibers of the shaker muscle of rattlesnakes have independently evolved similar traits, permitting tail rattling at approximately 90 Hz. PMID:8755609

Stability properties and fast ion confinement of hybrid tokamak plasma configurations

NASA Astrophysics Data System (ADS)

Graves, J. P.; Brunetti, D.; Pfefferle, D.; Faustin, J. M. P.; Cooper, W. A.; Kleiner, A.; Lanthaler, S.; Patten, H. W.; Raghunathan, M.

2015-11-01

In hybrid scenarios with flat q just above unity, extremely fast growing tearing modes are born from toroidal sidebands of the near resonant ideal internal kink mode. New scalings of the growth rate with the magnetic Reynolds number arise from two fluid effects and sheared toroidal flow. Non-linear saturated 1/1 dominant modes obtained from initial value stability calculation agree with the amplitude of the 1/1 component of a 3D VMEC equilibrium calculation. Viable and realistic equilibrium representation of such internal kink modes allow fast ion studies to be accurately established. Calculations of MAST neutral beam ion distributions using the VENUS-LEVIS code show very good agreement of observed impaired core fast ion confinement when long lived modes occur. The 3D ICRH code SCENIC also enables the establishment of minority RF distributions in hybrid plasmas susceptible to saturated near resonant internal kink modes.

Perforated peptic ulcer (PPU) in pregnancy during Ramadan fasting.

PubMed

Gali, B M; Ibrahim, A G; Chama, C M; Mshelia, H B; Abubakar, A; Takai, I U; Takie, U; Bwala, S

2011-01-01

Perforated Peptic Ulcer (PPU) is extremely rare in pregnancy. We report a case of perforated peptic ulcer in pregnancy during Ramadan fasting. The patient is a 16 years old primigravida who presented with features of peritonitis at 28weeks of gestation while fasting during Ramadan. Ultrasound scan reported a singleton live fetus at 28 weeks gestation. At laparotomy via upper midline incision; a 1 cm roundish perforation located on the duodenum anteriorly was found with about a litre of gastric juice mixed with blood and food particles in the peritoneal cavity. The perforation was close transversely with omental patch (Modified Graham's patch) and peritoneal lavage done with warm saline. She had a preterm delivery of a 1 kg baby 3 days post-operatively by a spontaneous vaginal delivery, but the baby died 3 days later. Perforated Peptic Ulcer(PPU) though rare in pregnancy can occur and fasting can be a risk factor.

Trends and Bioclimatic Assessment of Extreme Indices: Emerging Insights for Rainfall Derivative Crop Microinsurance in Central-West Nigeria

NASA Astrophysics Data System (ADS)

Awolala, D. O.

2015-12-01

Scientific predictions have forecasted increasing economic losses by which farming households will be forced to consider new adaptation pathways to close the food gap and be income secure. Pro-poor adaptation planning decisions therefore must rely on location-specific details from systematic assessment of extreme climate indices to provide template for most suitable financial adaptation instruments. This paper examined critical loss point to water stress in maize production and risk-averse behaviour to extreme local climate in Central West Nigeria. Trends of extreme indices and bio-climatic assessment based on RClimDex for numerical weather predictions were carried out using a 3-decade time series daily observational climate data of the sub-humid region. The study reveals that the flowering and seed formation stage was identified as the most critical loss point when seed formation is a function of per unit soil water available for uptake. The sub-humid has a bi-modal rainfall pattern but faces longer dry spell with a fast disappearing mild climate measured by budyko evaporation of 80.1%. Radiation index of dryness of 1.394 confirms the region is rapidly becoming drier at an evaporation rate of 949 mm/year and rainfall deficit of 366 mm/year. Net primary production from rainfall is fast declining by 1634 g(DM)/m2/year. These conditions influenced by monthly rainfall uncertainties are associated with losses of standing crops because farmers are uncertain of rainfall probability distribution especially during most important vegetative stage. In a simulated warmer climate, an absolute dryness of months was observed compared with 4 dry months in a normal climate which explains triggers of food deficits and income losses. Positive coefficients of tropical nights (TR20), warm nights (TN90P) and warm days (TX90P), and the negative coefficient of cold days (TX10P) with time are significant at P<0.05. The increasing gradient of warm spell indicator (WSDI), the decreasing gradients of cold nights (TN10P) and cold days (TX10P) are added evidence of aridity arising from increasing rainfall deficits. This paper recommends that the region needs rainfall-based index microinsurance adaptation financial instruments capable of sharing covariate shocks with farmers within an incentive-based risk sharing framework.

Noble Gases in Dust Returned by Hayabusa — Clues to Asteroid Itokawa's History?

NASA Astrophysics Data System (ADS)

Busemann, H.; Alwmark, C.; Bajt, S.; Böttger, U.; Crowther, S. A.; Gilmour, J. D.; Heitmann, U.; Hübers, H.-W.; Meier, M. M. M.; Pavlov, S.; Schade, U.; Spring, N. H.; Weber, I.

2014-09-01

We discuss the first detection of Xe in asteroid Itokawa dust, the uniformly short exposure of the dust to cosmic rays, possibly resulting from the extremely fast erosion present on small asteroids, and potential implications for Itokawa’s history.

Extreme ultraviolet spectroscopy diagnostics of low-temperature plasmas based on a sliced multilayer grating and glass capillary optics.

PubMed

Kantsyrev, V L; Safronova, A S; Williamson, K M; Wilcox, P; Ouart, N D; Yilmaz, M F; Struve, K W; Voronov, D L; Feshchenko, R M; Artyukov, I A; Vinogradov, A V

2008-10-01

New extreme ultraviolet (EUV) spectroscopic diagnostics of relatively low-temperature plasmas based on the application of an EUV spectrometer and fast EUV diodes combined with glass capillary optics is described. An advanced high resolution dispersive element sliced multilayer grating was used in the compact EUV spectrometer. For monitoring of the time history of radiation, filtered fast EUV diodes were used in the same spectral region (>13 nm) as the EUV spectrometer. The radiation from the plasma was captured by using a single inexpensive glass capillary that was transported onto the spectrometer entrance slit and EUV diode. The use of glass capillary optics allowed placement of the spectrometer and diodes behind the thick radiation shield outside the direction of a possible hard x-ray radiation beam and debris from the plasma source. The results of the testing and application of this diagnostic for a compact laser plasma source are presented. Examples of modeling with parameters of plasmas are discussed.

The influence of mid-latitude storm tracks on hot, cold, dry and wet extremes

PubMed Central

Lehmann, Jascha; Coumou, Dim

2015-01-01

Changes in mid-latitude circulation can strongly affect the number and intensity of extreme weather events. In particular, high-amplitude quasi-stationary planetary waves have been linked to prolonged weather extremes at the surface. In contrast, analyses of fast-traveling synoptic-scale waves and their direct influence on heat and cold extremes are scarce though changes in such waves have been detected and are projected for the 21st century. Here we apply regression analyses of synoptic activity with surface temperature and precipitation in monthly gridded observational data. We show that over large parts of mid-latitude continental regions, summer heat extremes are associated with low storm track activity. In winter, the occurrence of cold spells is related to low storm track activity over parts of eastern North America, Europe, and central- to eastern Asia. Storm tracks thus have a moderating effect on continental temperatures. Pronounced storm track activity favors monthly rainfall extremes throughout the year, whereas dry spells are associated with a lack thereof. Trend analyses reveal significant regional changes in recent decades favoring the occurrence of cold spells in the eastern US, droughts in California and heat extremes over Eurasia. PMID:26657163

A modified estimation distribution algorithm based on extreme elitism.

PubMed

Gao, Shujun; de Silva, Clarence W

2016-12-01

An existing estimation distribution algorithm (EDA) with univariate marginal Gaussian model was improved by designing and incorporating an extreme elitism selection method. This selection method highlighted the effect of a few top best solutions in the evolution and advanced EDA to form a primary evolution direction and obtain a fast convergence rate. Simultaneously, this selection can also keep the population diversity to make EDA avoid premature convergence. Then the modified EDA was tested by means of benchmark low-dimensional and high-dimensional optimization problems to illustrate the gains in using this extreme elitism selection. Besides, no-free-lunch theorem was implemented in the analysis of the effect of this new selection on EDAs. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Dual Ion Spectrometers and Their Calibration for the Fast Plasma Investigation on NASA's Magnetospheric Multiscale Mission

NASA Technical Reports Server (NTRS)

Coffey, V. N.; Chandler, M. O.

2017-01-01

The scientific target of NASA's Magnetospheric Multiscale (MMS) mission is to study the fundamentally important phenomenon of magnetic reconnection. Theoretical models of this process predict a small size, on the order of hundred kilometers, for the ion diffusion region where ions are demagnetized at the dayside magnetopause. This region may typically sweep over the spacecraft at relatively high speeds of 50 km/s, requiring the fast plasma investigation (FPI) instrument suite to have an extremely high time resolution for measurements of the 3D particle distribution functions. As part of the FPI on MMS, the 16 dual ion spectrometers (DIS) will provide fast (150 ms) 3D ion velocity distributions, from 10 to 30,000 eV/q, by combining the measurements from four dual spectrometers on each of four MMS spacecraft. For any multispacecraft mission, the response uniformity among the spectrometer set assumes an enhanced importance. Due to these demanding instrument requirements and the effort of calibrating more than 32 sensors (16 × 2) within a tight schedule, a highly systematic and precise calibration was required for measurement repeatability. To illustrate how this challenge was met, a brief overview of the FPI DIS was presented with a detailed discussion of the calibration method of approach and implementation. Finally, a discussion of DIS performance results, their unit-to-unit variation, and the lessons learned from this calibration effort are presented.

Unlocking the Barite Paleoproductivity Proxy: Using a New Barite Extraction Method to Understand Productivity Trends During the Eocene Greenhouse

NASA Astrophysics Data System (ADS)

House, B. M.; Norris, R. D.

2017-12-01

The Early Eocene Climatic Optimum (EECO) around 50 Ma was a sustained period of extreme global warmth with ocean bottom water temperatures of up to 12° C. The marine biologic response to such climatic extremes is unclear, however, in part because proxies that integrate ecosystem-wide productivity signals are scarce. While the accumulation of marine barite (BaSO4) is one such proxy, its applicability has remained limited due to the difficulty in reliably quantifying barite. Discrete measurements of barite content in marine sediments are laborious, and indirect estimates provide unclear results. We have developed a fast, high-throughput method for reliable measurement of barite content that relies on selective extraction of barite rather than sample digestion and quantification of remaining barite. Tests of the new method reveal that it gives the expected results for a wide variety of sediment types and can quantitatively extract 10-100 times the amount of barite typically encountered in natural sediments. Altogether, our method provides an estimated ten-fold increase in analysis efficiency over current sample digestion methods and also works reliably on small ( 1 g or less) sediment samples. Furthermore, the instrumentation requirements of this method are minor, so samples can be analyzed in shipboard labs to generate real-time paleoproductivity records during coring expeditions. Because of the magnitude of throughput improvement, this new technique will permit the generation of large datasets needed to address previously intractable paleoclimate and paleoceanographic questions. One such question is how export productivity changes during climatic extremes. We used our new method to analyze globally distributed sediment cores to determine if the EECO represented a period of anomalous export productivity either due to higher rates of primary production or more vigorous heterotrophic metabolisms. An increase in export productivity could provide a mechanism for exiting periods of extreme warmth, and understanding the interplay between temperature, atmospheric CO2 levels, and export productivity during the EECO will help clarify how the marine biologic system functions as a whole.

Power Hardware-in-the-Loop Testing of Multiple Photovoltaic Inverters' Volt-Var Control with Real-Time Grid Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty, Sudipta; Nelson, Austin; Hoke, Anderson

2016-12-12

Traditional testing methods fall short in evaluating interactions between multiple smart inverters providing advanced grid support functions due to the fact that such interactions largely depend on their placements on the electric distribution systems with impedances between them. Even though significant concerns have been raised by the utilities on the effects of such interactions, little effort has been made to evaluate them. In this paper, power hardware-in-the-loop (PHIL) based testing was utilized to evaluate autonomous volt-var operations of multiple smart photovoltaic (PV) inverters connected to a simple distribution feeder model. The results provided in this paper show that depending onmore » volt-var control (VVC) parameters and grid parameters, interaction between inverters and between the inverter and the grid is possible in some extreme cases with very high VVC slopes, fast response times and large VVC response delays.« less

Adaptation to Low Temperature Exposure Increases Metabolic Rates Independently of Growth Rates

PubMed Central

Williams, Caroline M.; Szejner-Sigal, Andre; Morgan, Theodore J.; Edison, Arthur S.; Allison, David B.; Hahn, Daniel A.

2016-01-01

Metabolic cold adaptation is a pattern where ectotherms from cold, high-latitude, or -altitude habitats have higher metabolic rates than ectotherms from warmer habitats. When found, metabolic cold adaptation is often attributed to countergradient selection, wherein short, cool growing seasons select for a compensatory increase in growth rates and development times of ectotherms. Yet, ectotherms in high-latitude and -altitude environments face many challenges in addition to thermal and time constraints on lifecycles. In addition to short, cool growing seasons, high-latitude and - altitude environments are characterized by regular exposure to extreme low temperatures, which cause ectotherms to enter a transient state of immobility termed chill coma. The ability to resume activity quickly after chill coma increases with latitude and altitude in patterns consistent with local adaptation to cold conditions. We show that artificial selection for fast and slow chill coma recovery among lines of the fly Drosophila melanogaster also affects rates of respiratory metabolism. Cold-hardy fly lines, with fast recovery from chill coma, had higher respiratory metabolic rates than control lines, with cold-susceptible slow-recovering lines having the lowest metabolic rates. Fast chill coma recovery was also associated with higher respiratory metabolism in a set of lines derived from a natural population. Although their metabolic rates were higher than control lines, fast-recovering cold-hardy lines did not have faster growth rates or development times than control lines. This suggests that raised metabolic rates in high-latitude and -altitude species may be driven by adaptation to extreme low temperatures, illustrating the importance of moving “Beyond the Mean”. PMID:27103615

Growth of Acousto-Optic Crystals for Applications in Infrared Region of Spectrum

DTIC Science & Technology

2005-04-30

Acousto - optic (AO) modulators, deflectors, filters offer convenience, reliability, compact size and fast speed in regulation of optical beams. So far...extremely low acousto - optic figure of merit, which automatically results in high requirements on driving electric power and poor diffraction efficiency. It

Decoupling of microbial carbon, nitrogen, and phosphorus cycling in response to extreme temperature events

PubMed Central

Mooshammer, Maria; Hofhansl, Florian; Frank, Alexander H.; Wanek, Wolfgang; Hämmerle, Ieda; Leitner, Sonja; Schnecker, Jörg; Wild, Birgit; Watzka, Margarete; Keiblinger, Katharina M.; Zechmeister-Boltenstern, Sophie; Richter, Andreas

2017-01-01

Predicted changes in the intensity and frequency of climate extremes urge a better mechanistic understanding of the stress response of microbially mediated carbon (C) and nutrient cycling processes. We analyzed the resistance and resilience of microbial C, nitrogen (N), and phosphorus (P) cycling processes and microbial community composition in decomposing plant litter to transient, but severe, temperature disturbances, namely, freeze-thaw and heat. Disturbances led temporarily to a more rapid cycling of C and N but caused a down-regulation of P cycling. In contrast to the fast recovery of the initially stimulated C and N processes, we found a slow recovery of P mineralization rates, which was not accompanied by significant changes in community composition. The functional and structural responses to the two distinct temperature disturbances were markedly similar, suggesting that direct negative physical effects and costs associated with the stress response were comparable. Moreover, the stress response of extracellular enzyme activities, but not that of intracellular microbial processes (for example, respiration or N mineralization), was dependent on the nutrient content of the resource through its effect on microbial physiology and community composition. Our laboratory study provides novel insights into the mechanisms of microbial functional stress responses that can serve as a basis for field studies and, in particular, illustrates the need for a closer integration of microbial C-N-P interactions into climate extremes research. PMID:28508070

Non-destructive determination of Malondialdehyde (MDA) distribution in oilseed rape leaves by laboratory scale NIR hyperspectral imaging

PubMed Central

Kong, Wenwen; Liu, Fei; Zhang, Chu; Zhang, Jianfeng; Feng, Hailin

2016-01-01

The feasibility of hyperspectral imaging with 400–1000 nm was investigated to detect malondialdehyde (MDA) content in oilseed rape leaves under herbicide stress. After comparing the performance of different preprocessing methods, linear and nonlinear calibration models, the optimal prediction performance was achieved by extreme learning machine (ELM) model with only 23 wavelengths selected by competitive adaptive reweighted sampling (CARS), and the result was RP = 0.929 and RMSEP = 2.951. Furthermore, MDA distribution map was successfully achieved by partial least squares (PLS) model with CARS. This study indicated that hyperspectral imaging technology provided a fast and nondestructive solution for MDA content detection in plant leaves. PMID:27739491

NONMEMory: a run management tool for NONMEM.

PubMed

Wilkins, Justin J

2005-06-01

NONMEM is an extremely powerful tool for nonlinear mixed-effect modelling and simulation of pharmacokinetic and pharmacodynamic data. However, it is a console-based application whose output does not lend itself to rapid interpretation or efficient management. NONMEMory has been created to be a comprehensive project manager for NONMEM, providing detailed summary, comparison and overview of the runs comprising a given project, including the display of output data, simple post-run processing, fast diagnostic plots and run output management, complementary to other available modelling aids. Analysis time ought not to be spent on trivial tasks, and NONMEMory's role is to eliminate these as far as possible by increasing the efficiency of the modelling process. NONMEMory is freely available from http://www.uct.ac.za/depts/pha/nonmemory.php.

A computationally fast, reduced model for simulating landslide dynamics and tsunamis generated by landslides in natural terrains

NASA Astrophysics Data System (ADS)

Mohammed, F.

2016-12-01

Landslide hazards such as fast-moving debris flows, slow-moving landslides, and other mass flows cause numerous fatalities, injuries, and damage. Landslide occurrences in fjords, bays, and lakes can additionally generate tsunamis with locally extremely high wave heights and runups. Two-dimensional depth-averaged models can successfully simulate the entire lifecycle of the three-dimensional landslide dynamics and tsunami propagation efficiently and accurately with the appropriate assumptions. Landslide rheology is defined using viscous fluids, visco-plastic fluids, and granular material to account for the possible landslide source materials. Saturated and unsaturated rheologies are further included to simulate debris flow, debris avalanches, mudflows, and rockslides respectively. The models are obtained by reducing the fully three-dimensional Navier-Stokes equations with the internal rheological definition of the landslide material, the water body, and appropriate scaling assumptions to obtain the depth-averaged two-dimensional models. The landslide and tsunami models are coupled to include the interaction between the landslide and the water body for tsunami generation. The reduced models are solved numerically with a fast semi-implicit finite-volume, shock-capturing based algorithm. The well-balanced, positivity preserving algorithm accurately accounts for wet-dry interface transition for the landslide runout, landslide-water body interface, and the tsunami wave flooding on land. The models are implemented as a General-Purpose computing on Graphics Processing Unit-based (GPGPU) suite of models, either coupled or run independently within the suite. The GPGPU implementation provides up to 1000 times speedup over a CPU-based serial computation. This enables simulations of multiple scenarios of hazard realizations that provides a basis for a probabilistic hazard assessment. The models have been successfully validated against experiments, past studies, and field data for landslides and tsunamis.

The Mercury System: Embedding Computation into Disk Drives

DTIC Science & Technology

2004-08-20

enabling technologies to build extremely fast data search engines . We do this by moving the search closer to the data, and performing it in hardware...engine searches in parallel across a disk or disk surface 2. System Parallelism: Searching is off-loaded to search engines and main processor can

When Food Consumes You: Taking Eating to Extremes

MedlinePlus

... to weight gain and can be associated with obesity. When binge-eating is followed by “purging,” it’s called bulimia nervosa. People with bulimia nervosa may follow binge-eating by vomiting or taking laxatives to purge, over-exercising, or fasting. They’re often able to maintain a normal ...

Mindful Organizing as a Paradigm to Develop Managers

ERIC Educational Resources Information Center

Gebauer, Annette

2013-01-01

How can managers prepare for extreme but exceptional events and for the challenge of managing complexity and uncertainty in their daily business? Confronted with the challenge of achieving high and reliable performance in risk-prone, fast-paced, and unpredictable environments, managers and management scholars can learn a lot from the organizing…

Real-time detection of an extremely high signal-to-noise ratio fast radio burst during observations of PSR J2124-3358

NASA Astrophysics Data System (ADS)

Oslowsk, S.; Shannon, R. M..; Jameson, Andrew; Sarkissian, J. M..; Bailes, M.; Andreoni, I.; Bhat, N. D. R..; Coles, W. A.; Dai, S.; Dempsey, J.; Hobbs, G.; Keith, M. J.; Kerr, M.; Manchester, R. N.; Lasky, P. D.; Levin, Y.; Parthasarathy, A.; Ravi, V.; Reardon, D. J.; Rosado, P. A.; Russell, C. J.; Spiewak, R.; Van Straten, W.; Toomey, L.; Wang, J. B.; Wen, L.; You, X.-P.; Zhang, L.; Zhang, S.; Zhu, X.-J.

2018-03-01

The Parkes Pulsar Timing Array (Manchester et al. 2013) project monitors pulse times of arrival for 24 millisecond pulsars in the Galaxy on a fortnightly cadence using the multibeam receiver on the CSIRO 64-m Parkes Telescope.

Surrogate waveform models

NASA Astrophysics Data System (ADS)

Blackman, Jonathan; Field, Scott; Galley, Chad; Scheel, Mark; Szilagyi, Bela; Tiglio, Manuel

2015-04-01

With the advanced detector era just around the corner, there is a strong need for fast and accurate models of gravitational waveforms from compact binary coalescence. Fast surrogate models can be built out of an accurate but slow waveform model with minimal to no loss in accuracy, but may require a large number of evaluations of the underlying model. This may be prohibitively expensive if the underlying is extremely slow, for example if we wish to build a surrogate for numerical relativity. We examine alternate choices to building surrogate models which allow for a more sparse set of input waveforms. Research supported in part by NSERC.

Evaluation of Fast Switching Diode 1N4448 Over a Wide Temperature Range

NASA Technical Reports Server (NTRS)

Boomer, Kristen; Damron, James; Gray, Josh; Hammoud, Ahmad

2017-01-01

Electronic parts used in the design of power systems geared for space applications are often exposed to extreme temperatures and thermal cycling. Limited data exist on the performance and reliability of commercial-off-the-shelf (COTS) electronic parts at temperatures beyond the manufacturers specified operating temperature range. This report summarizes preliminary results obtained on the evaluation of automotive-grade, fast switching diodes over a wide temperature range and thermal cycling. The investigations were carried out to establish a baseline on functionality of these diodes and to determine suitability for use outside their recommended temperature limits.

Fast and accurate modeling of nonlinear pulse propagation in graded-index multimode fibers.

PubMed

Conforti, Matteo; Mas Arabi, Carlos; Mussot, Arnaud; Kudlinski, Alexandre

2017-10-01

We develop a model for the description of nonlinear pulse propagation in multimode optical fibers with a parabolic refractive index profile. It consists of a 1+1D generalized nonlinear Schrödinger equation with a periodic nonlinear coefficient, which can be solved in an extremely fast and efficient way. The model is able to quantitatively reproduce recently observed phenomena like geometric parametric instability and broadband dispersive wave emission. We envisage that our equation will represent a valuable tool for the study of spatiotemporal nonlinear dynamics in the growing field of multimode fiber optics.

A fast isogeometric BEM for the three dimensional Laplace- and Helmholtz problems

NASA Astrophysics Data System (ADS)

Dölz, Jürgen; Harbrecht, Helmut; Kurz, Stefan; Schöps, Sebastian; Wolf, Felix

2018-03-01

We present an indirect higher order boundary element method utilising NURBS mappings for exact geometry representation and an interpolation-based fast multipole method for compression and reduction of computational complexity, to counteract the problems arising due to the dense matrices produced by boundary element methods. By solving Laplace and Helmholtz problems via a single layer approach we show, through a series of numerical examples suitable for easy comparison with other numerical schemes, that one can indeed achieve extremely high rates of convergence of the pointwise potential through the utilisation of higher order B-spline-based ansatz functions.

Partial fast-to-slow conversion of regenerating rat fast-twitch muscle by chronic low-frequency stimulation.

PubMed

Pette, Dirk; Sketelj, Janez; Skorjanc, Dejan; Leisner, Elmi; Traub, Irmtrud; Bajrović, Fajko

2002-01-01

Chronic low-frequency stimulation (CLFS) of rat fast-twitch muscles induces sequential transitions in myosin heavy chain (MHC) expression from MHCIIb --> MHCIId/x --> MHCIIa. However, the 'final' step of the fast-to-slow transition, i.e., the upregulation of MHCI, has been observed only after extremely long stimulation periods. Assuming that fibre degeneration/regeneration might be involved in the upregulation of slow myosin, we investigated the effects of CLFS on extensor digitorum longus (EDL) muscles regenerating after bupivacaine-induced fibre necrosis. Normal, non-regenerating muscles responded to both 30- and 60-day CLFS with fast MHC isoform transitions (MHCIIb --> MHCIId --> MHCIIa) and only slight increases in MHCI. CLFS of regenerating EDL muscles caused similar transitions among the fast isoforms but, in addition, caused significant increases in MHCI (to approximately 30% relative concentration). Stimulation periods of 30 and 60 days induced similar changes in the regenerating bupivacaine-treated muscles, indicating that the upregulation of slow myosin was restricted to regenerating fibres, but only during an early stage of regeneration. These results suggest that satellite cells and/or regenerating fast rat muscle fibres are capable of switching directly to a slow program under the influence of CLFS and, therefore, appear to be more malleable than adult fibres.

Fast charging of lithium-ion batteries at all temperatures.

PubMed

Yang, Xiao-Guang; Zhang, Guangsheng; Ge, Shanhai; Wang, Chao-Yang

2018-06-25

Fast charging is a key enabler of mainstream adoption of electric vehicles (EVs). None of today's EVs can withstand fast charging in cold or even cool temperatures due to the risk of lithium plating. Efforts to enable fast charging are hampered by the trade-off nature of a lithium-ion battery: Improving low-temperature fast charging capability usually comes with sacrificing cell durability. Here, we present a controllable cell structure to break this trade-off and enable lithium plating-free (LPF) fast charging. Further, the LPF cell gives rise to a unified charging practice independent of ambient temperature, offering a platform for the development of battery materials without temperature restrictions. We demonstrate a 9.5 Ah 170 Wh/kg LPF cell that can be charged to 80% state of charge in 15 min even at -50 °C (beyond cell operation limit). Further, the LPF cell sustains 4,500 cycles of 3.5-C charging in 0 °C with <20% capacity loss, which is a 90× boost of life compared with a baseline conventional cell, and equivalent to >12 y and >280,000 miles of EV lifetime under this extreme usage condition, i.e., 3.5-C or 15-min fast charging at freezing temperatures.

Radio emissions from pulsar companions: a refutable explanation for galactic transients and fast radio bursts

NASA Astrophysics Data System (ADS)

Mottez, F.; Zarka, P.

2014-09-01

Context. The six known highly dispersed fast radio bursts are attributed to extragalactic radio sources that are of unknown origin but extremely energetic. We propose here a new explanation that does not require an extreme release of energy and involves a body (planet, asteroid, white dwarf) orbiting an extragalactic pulsar. Aims: We investigate a theory of radio waves associated with such pulsar-orbiting bodies. We focus our analysis on the waves emitted from the magnetic wake of the body in the pulsar wind. After deriving their properties, we compare them with the observations of various transient radio signals to determine whether they could originate from pulsar-orbiting bodies. Methods: The analysis is based on the theory of Alfvén wings: for a body immersed in a pulsar wind, a system of two stationary Alfvén waves is attached to the body, provided that the wind is highly magnetised. When they are destabilised through plasma instabilities, Alfvén wings can be the locus of strong radio sources that are convected with the pulsar wind. By assuming a cyclotron maser instability operating in the Alfvén wings, we make predictions about the shape, frequencies, and brightness of the resulting radio emissions. Results: Because of the beaming by relativistic aberration, the signal is seen only when the companion is perfectly aligned between its parent pulsar and the observer, as is the case for occultations. For pulsar winds with a high Lorentz factor (≥104), the whole duration of the radio event does not exceed a few seconds, and it is composed of one to four peaks that last a few milliseconds each and are detectable up to distances of several Mpc. The Lorimer burst, the three isolated pulses of PSR J1928+15, and the recently detected fast radio bursts are all compatible with our model. According to it, these transient signals should repeat periodically with the companion's orbital period. Conclusions: The search of pulsar-orbiting bodies could be an exploration theme for new- or next-generation radio telescopes.

A Fast Monte Carlo Simulation for the International Linear Collider Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furse, D.; /Georgia Tech

2005-12-15

The following paper contains details concerning the motivation for, implementation and performance of a Java-based fast Monte Carlo simulation for a detector designed to be used in the International Linear Collider. This simulation, presently included in the SLAC ILC group's org.lcsim package, reads in standard model or SUSY events in STDHEP file format, stochastically simulates the blurring in physics measurements caused by intrinsic detector error, and writes out an LCIO format file containing a set of final particles statistically similar to those that would have found by a full Monte Carlo simulation. In addition to the reconstructed particles themselves, descriptionsmore » of the calorimeter hit clusters and tracks that these particles would have produced are also included in the LCIO output. These output files can then be put through various analysis codes in order to characterize the effectiveness of a hypothetical detector at extracting relevant physical information about an event. Such a tool is extremely useful in preliminary detector research and development, as full simulations are extremely cumbersome and taxing on processor resources; a fast, efficient Monte Carlo can facilitate and even make possible detector physics studies that would be very impractical with the full simulation by sacrificing what is in many cases inappropriate attention to detail for valuable gains in time required for results.« less

Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal NeuronsV⃞

PubMed Central

Kaether, Christoph; Skehel, Paul; Dotti, Carlos G.

2000-01-01

Neurons transport newly synthesized membrane proteins along axons by microtubule-mediated fast axonal transport. Membrane proteins destined for different axonal subdomains are thought to be transported in different transport carriers. To analyze this differential transport in living neurons, we tagged the amyloid precursor protein (APP) and synaptophysin (p38) with green fluorescent protein (GFP) variants. The resulting fusion proteins, APP-yellow fluorescent protein (YFP), p38-enhanced GFP, and p38-enhanced cyan fluorescent protein, were expressed in hippocampal neurons, and the cells were imaged by video microscopy. APP-YFP was transported in elongated tubules that moved extremely fast (on average 4.5 μm/s) and over long distances. In contrast, p38-enhanced GFP-transporting structures were more vesicular and moved four times slower (0.9 μm/s) and over shorter distances only. Two-color video microscopy showed that the two proteins were sorted to different carriers that moved with different characteristics along axons of doubly transfected neurons. Antisense treatment using oligonucleotides against the kinesin heavy chain slowed down the long, continuous movement of APP-YFP tubules and increased frequency of directional changes. These results demonstrate for the first time directly the sorting and transport of two axonal membrane proteins into different carriers. Moreover, the extremely fast-moving tubules represent a previously unidentified type of axonal carrier. PMID:10749925

Effects of fasting and feeding on the fast-start swimming performance of southern catfish Silurus meridionalis.

PubMed

Yan, G J; He, X K; Cao, Z D; Fu, S J

2015-01-21

This study investigated the effects of fasting and feeding on the fast-start escape swimming performance of juvenile southern catfish Silurus meridionalis, a sit-and-wait forager that encounters extreme fasting and famine frequently during its lifespan. Ten to 30 days of fasting resulted in no significant change in most of the variables measured in the fast-start response except a 20-30% decrease in the escape distance during the first 120 ms (D 120ms ) relative to the control group (48 h after feeding). The ratio of the single-bend (SB) response (lower energetic expenditure) to the double-bend (DB) response increased significantly from 0% in the control group to 75 and 82·5% in the 20 and 30 day fasting groups, respectively. Satiated feeding (25% of body mass) resulted in a significantly lower (36·6%) maximum linear velocity (V max ) and a significantly lower (43·3%) D 120ms than in non-fed fish (control group, 48 h after feeding). Half-satiated feeding (12·5% of body mass), however, showed no significant effects on any of the measured variables of the fast-start response relative to control fish. It is suggested that the increase in the ratio of SB:DB responses with fasting in S. meridionalis may reflect a trade-off between energy conservation and maintaining high V max , while variables of fast-start performance were more sensitive to feeding than fasting might be an adaptive strategy to their foraging mode and food availability in their habitat. © 2015 The Fisheries Society of the British Isles.

The fast food and obesity link: consumption patterns and severity of obesity.

PubMed

Garcia, Ginny; Sunil, Thankam S; Hinojosa, Pedro

2012-05-01

Rates of extreme forms of obesity are rapidly rising, as is the use of bariatric surgery for its treatment. The aim of the present study was to examine selected behavioral factors associated with severity of obesity among preoperative bariatric surgery patients in the San Antonio area, focusing specifically on the effects of fast food consumption. We used ordered logistic regression to model behavioral and attitudinal effects on obesity outcomes among 270 patients. These outcomes were based on the severity of obesity and were measured on the basis of body mass index. Our results indicated that, among the behavioral factors, fast food consumption exerted the largest influence on higher levels of obesity. These remained after controlling for several social and demographic characteristics. Our findings suggest that higher rates of fast food consumption are connected to the increasing rates of severe obesity. Given that morbid and super morbid obesity rates are growing at a more advanced pace than moderate obesity, it is necessary to explore the behavioral characteristics associated with these trends.

Fully-reversible optical sensor for hydrogen peroxide with fast response.

PubMed

Ding, Longjiang; Chen, Siyu; Zhang, Wei; Zhang, Yinglu; Wang, Xu-Dong

2018-05-09

A fully reversible optical sensor for hydrogen peroxide with fast response is presented. The sensor was fabricated by in-situ growing ultra-small platinum nanoparticles (PtNPs) inside the pores of fibrous silica particles (KCC-1). The nanocomposite was then embedded into a hydrogel matrix and form a sensor layer, the immobilized PtNPs can catalytically convert hydrogen peroxide into molecular oxygen, which is measured via luminescent quenching based oxygen sensor underneath. Owing to the high porosity and permeability of KCC-1 and high local concentration of PtNPs, the sensor exhibits fast response (less than 1 min) and full reversibility. The measurement range of the sensor covers 1.0 μM to 10.0 mM, and very small amount of sample is required during measurement (200 μL). Because of its high stability, excellent reversibility and selectivity, and extremely fast response, the sensor could fulfill all industry requirements for real-time measurement, and fill market vacancy.

A case of idiopathic type 1 diabetes with subsequent recovery of endogenous insulin secretion despite initial diagnosis of fulminant type 1 diabetes.

PubMed

Kaneko, Keizo; Satake, Chihiro; Yamamoto, Junpei; Takahashi, Hironori; Sawada, Shojiro; Imai, Junta; Yamada, Tetsuya; Katagiri, Hideki

2017-03-31

Fulminant type 1 diabetes is characterized by remarkably rapid and complete β-cell destruction. The established diagnostic criteria include the occurrence of diabetic ketosis soon after the onset of hyperglycemic symptoms, elevated plasma glucose with relatively low HbA1c at the first visit, and extremely low C-peptide. Serum C-peptide levels remain extremely low over a prolonged period. A 26-year-old-man with diabetic ketosis was admitted to our hospital. His relatively low HbA1c (7.6%), despite marked hyperglycemia (593 mg/dL) with marked ketosis, indicated abrupt onset. Islet-related autoantibodies were all negative. His data at onset, including extremely low serum C-peptide (0.11 ng/mL), fulfilled the diagnostic criteria for fulminant type 1 diabetes. However, his fasting serum C-peptide levels subsequently showed substantial recovery. While fasting C-peptide stayed below 0.30 ng/mL during the first two months post onset, the levels gradually increased and thereafter fluctuated between 0.60 ng/mL and 0.90 ng/mL until 24 months post onset. By means of multiple daily insulin injection therapy, his glycemic control has been well maintained (HbA1c approximately 6.0%), with relatively small glycemic fluctuations evaluated by continuous glucose monitoring. This clinical course suggests that, despite the abrupt diabetes onset with extremely low C-peptide levels, substantial numbers of β-cells had been spared destruction and their function later showed gradual recovery. Diabetes has come to be considered a much more heterogeneous disease than the present subdivisions suggest. This case does not fit into the existing concepts of either fulminant type 1 or ketosis-prone diabetes, thereby further highlighting the heterogeneity of idiopathic type 1 diabetes.

America's Elderly.

ERIC Educational Resources Information Center

Soldo, Beth J.; Agree, Emily M.

1988-01-01

The older population in the United States grew twice as fast as the rest of the population in the last 20 years. This growth is expected to accelerate early in the next century as the large baby-boom cohorts move through middle age and become elderly. Substantial improvements in life expectancy at all ages, particularly at extreme old age, mean…

A Quiet Transformation

ERIC Educational Resources Information Center

Dierke, James S.

2012-01-01

The author's 40 years as an educator have led him to an important insight: stress is crippling the schools. On top of other extreme conditions in schools and on students, there is the pressure to achieve and succeed in a fast-paced, chaotic world. This pervasive stress compromises the physical health, and in turn the cognitive and psychological…

Ready, Aim, Perform! Targeted Micro-Training for Performance Intervention

ERIC Educational Resources Information Center

Carpenter, Julia; Forde, Dahlia S.; Stevens, Denise R.; Flango, Vincent; Babcock, Lisa K.

2016-01-01

The Department of Veterans Affairs has an immediate problem at hand. Tens of thousands of employees are working in a high-stress work environment where fast-paced daily production requirements are critical. Employees are faced with a tremendous backlog of veterans' claims. Unfortunately, not only are the claims extremely complex, but there is…

A model of spreading of sudden events on social networks

NASA Astrophysics Data System (ADS)

Wu, Jiao; Zheng, Muhua; Zhang, Zi-Ke; Wang, Wei; Gu, Changgui; Liu, Zonghua

2018-03-01

Information spreading has been studied for decades, but its underlying mechanism is still under debate, especially for those ones spreading extremely fast through the Internet. By focusing on the information spreading data of six typical events on Sina Weibo, we surprisingly find that the spreading of modern information shows some new features, i.e., either extremely fast or slow, depending on the individual events. To understand its mechanism, we present a susceptible-accepted-recovered model with both information sensitivity and social reinforcement. Numerical simulations show that the model can reproduce the main spreading patterns of the six typical events. By this model, we further reveal that the spreading can be speeded up by increasing either the strength of information sensitivity or social reinforcement. Depending on the transmission probability and information sensitivity, the final accepted size can change from continuous to discontinuous transition when the strength of the social reinforcement is large. Moreover, an edge-based compartmental theory is presented to explain the numerical results. These findings may be of significance on the control of information spreading in modern society.

A Fast Reduced Kernel Extreme Learning Machine.

PubMed

Deng, Wan-Yu; Ong, Yew-Soon; Zheng, Qing-Hua

2016-04-01

In this paper, we present a fast and accurate kernel-based supervised algorithm referred to as the Reduced Kernel Extreme Learning Machine (RKELM). In contrast to the work on Support Vector Machine (SVM) or Least Square SVM (LS-SVM), which identifies the support vectors or weight vectors iteratively, the proposed RKELM randomly selects a subset of the available data samples as support vectors (or mapping samples). By avoiding the iterative steps of SVM, significant cost savings in the training process can be readily attained, especially on Big datasets. RKELM is established based on the rigorous proof of universal learning involving reduced kernel-based SLFN. In particular, we prove that RKELM can approximate any nonlinear functions accurately under the condition of support vectors sufficiency. Experimental results on a wide variety of real world small instance size and large instance size applications in the context of binary classification, multi-class problem and regression are then reported to show that RKELM can perform at competitive level of generalized performance as the SVM/LS-SVM at only a fraction of the computational effort incurred. Copyright © 2015 Elsevier Ltd. All rights reserved.

Fast All-Sky Radiation Model for Solar Applications (FARMS): A Brief Overview of Mechanisms, Performance, and Applications: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Yu; Sengupta, Manajit

Solar radiation can be computed using radiative transfer models, such as the Rapid Radiation Transfer Model (RRTM) and its general circulation model applications, and used for various energy applications. Due to the complexity of computing radiation fields in aerosol and cloudy atmospheres, simulating solar radiation can be extremely time-consuming, but many approximations--e.g., the two-stream approach and the delta-M truncation scheme--can be utilized. To provide a new fast option for computing solar radiation, we developed the Fast All-sky Radiation Model for Solar applications (FARMS) by parameterizing the simulated diffuse horizontal irradiance and direct normal irradiance for cloudy conditions from the RRTMmore » runs using a 16-stream discrete ordinates radiative transfer method. The solar irradiance at the surface was simulated by combining the cloud irradiance parameterizations with a fast clear-sky model, REST2. To understand the accuracy and efficiency of the newly developed fast model, we analyzed FARMS runs using cloud optical and microphysical properties retrieved using GOES data from 2009-2012. The global horizontal irradiance for cloudy conditions was simulated using FARMS and RRTM for global circulation modeling with a two-stream approximation and compared to measurements taken from the U.S. Department of Energy's Atmospheric Radiation Measurement Climate Research Facility Southern Great Plains site. Our results indicate that the accuracy of FARMS is comparable to or better than the two-stream approach; however, FARMS is approximately 400 times more efficient because it does not explicitly solve the radiative transfer equation for each individual cloud condition. Radiative transfer model runs are computationally expensive, but this model is promising for broad applications in solar resource assessment and forecasting. It is currently being used in the National Solar Radiation Database, which is publicly available from the National Renewable Energy Laboratory at http://nsrdb.nrel.gov.« less

Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics.

PubMed

Warkiani, Majid Ebrahimi; Khoo, Bee Luan; Wu, Lidan; Tay, Andy Kah Ping; Bhagat, Ali Asgar S; Han, Jongyoon; Lim, Chwee Teck

2016-01-01

Circulating tumor cells (CTCs) are rare cancer cells that are shed from primary or metastatic tumors into the peripheral blood circulation. Phenotypic and genetic characterization of these rare cells can provide important information to guide cancer staging and treatment, and thus further research into their characteristics and properties is an area of considerable interest. In this protocol, we describe detailed procedures for the production and use of a label-free spiral microfluidic device to allow size-based isolation of viable CTCs using hydrodynamic forces that are present in curvilinear microchannels. This spiral system enables us to achieve ≥ 85% recovery of spiked cells across multiple cancer cell lines and 99.99% depletion of white blood cells in whole blood. The described spiral microfluidic devices can be produced at an extremely low cost using standard microfabrication and soft lithography techniques (2-3 d), and they can be operated using two syringe pumps for lysed blood samples (7.5 ml in 12.5 min for a three-layered multiplexed chip). The fast processing time and the ability to collect CTCs from a large patient blood volume allows this technique to be used experimentally in a broad range of potential genomic and transcriptomic applications.

In Situ Localized Growth of Ordered Metal Oxide Hollow Sphere Array on Microheater Platform for Sensitive, Ultra-Fast Gas Sensing.

PubMed

Rao, Ameya; Long, Hu; Harley-Trochimczyk, Anna; Pham, Thang; Zettl, Alex; Carraro, Carlo; Maboudian, Roya

2017-01-25

A simple and versatile strategy is presented for the localized on-chip synthesis of an ordered metal oxide hollow sphere array directly on a low power microheater platform to form a closely integrated miniaturized gas sensor. Selective microheater surface modification through fluorinated monolayer self-assembly and its subsequent microheater-induced thermal decomposition enables the position-controlled deposition of an ordered two-dimensional colloidal sphere array, which serves as a sacrificial template for metal oxide growth via homogeneous chemical precipitation; this strategy ensures control in both the morphology and placement of the sensing material on only the active heated area of the microheater platform, providing a major advantage over other methods of presynthesized nanomaterial integration via suspension coating or printing. A fabricated tin oxide hollow sphere-based sensor shows high sensitivity (6.5 ppb detection limit) and selectivity toward formaldehyde, and extremely fast response (1.8 s) and recovery (5.4 s) times. This flexible and scalable method can be used to fabricate high performance miniaturized gas sensors with a variety of hollow nanostructured metal oxides for a range of applications, including combining multiple metal oxides for superior sensitivity and tunable selectivity.

Metabolic cycles in a circannual hibernator

PubMed Central

Epperson, L. Elaine; Karimpour-Fard, Anis; Hunter, Lawrence E.

2011-01-01

Hibernation as manifested in ground squirrels is arguably the most plastic and extreme of physiological phenotypes in mammals. Homeostasis is challenged by prolonged fasting accompanied by heterothermy, yet must be facilitated for survival. We performed LC and GC-MS metabolomic profiling of plasma samples taken reproducibly during seven natural stages of the hibernator's year, three in summer and four in winter (each n ≥ 5), employing a nontargeted approach to define the metabolite shifts associated with the phenotype. We quantified 231 named metabolites; 106 of these altered significantly, demarcating a cycle within a cycle where torpor-arousal cycles recur during the winter portion of the seasonal cycle. A number of robust hibernation biomarkers that alter with season and winter stage are identified, including specific free fatty acids, antioxidants, and previously unpublished modified amino acids that are likely to be associated with the fasting state. The major pattern in metabolite levels is one of either depletion or accrual during torpor, followed by reversal to an apparent homeostatic level by interbout arousal. This finding provides new data that strongly support the predictions of a long-standing hypothesis that periodic arousals are necessary to restore metabolic homeostasis. PMID:21540299

Fast and stable redox reactions of MnO₂/CNT hybrid electrodes for dynamically stretchable pseudocapacitors.

PubMed

Gu, Taoli; Wei, Bingqing

2015-07-21

Pseudocapacitors, which are energy storage devices that take advantage of redox reactions to store electricity, have a different charge storage mechanism compared to lithium-ion batteries (LIBs) and electric double-layer capacitors (EDLCs), and they could realize further gains if they were used as stretchable power sources. The realization of dynamically stretchable pseudocapacitors and understanding of the underlying fundamentals of their mechanical-electrochemical relationship have become indispensable. We report herein the electrochemical performance of dynamically stretchable pseudocapacitors using buckled MnO2/CNT hybrid electrodes. The extremely small relaxation time constant of less than 0.15 s indicates a fast redox reaction at the MnO2/CNT hybrid electrodes, securing a stable electrochemical performance for the dynamically stretchable pseudocapacitors. This finding and the fundamental understanding gained from the pseudo-capacitive behavior coupled with mechanical deformation under a dynamic stretching mode would provide guidance to further improve their overall performance including a higher power density than LIBs, a higher energy density than EDLCs, and a long-life cycling stability. Most importantly, these results will potentially accelerate the applications of stretchable pseudocapacitors for flexible and biomedical electronics.

Event rate and reaction time performance in ADHD: Testing predictions from the state regulation deficit hypothesis using an ex-Gaussian model.

PubMed

Metin, Baris; Wiersema, Jan R; Verguts, Tom; Gasthuys, Roos; van Der Meere, Jacob J; Roeyers, Herbert; Sonuga-Barke, Edmund

2016-01-01

According to the state regulation deficit (SRD) account, ADHD is associated with a problem using effort to maintain an optimal activation state under demanding task settings such as very fast or very slow event rates. This leads to a prediction of disrupted performance at event rate extremes reflected in higher Gaussian response variability that is a putative marker of activation during motor preparation. In the current study, we tested this hypothesis using ex-Gaussian modeling, which distinguishes Gaussian from non-Gaussian variability. Twenty-five children with ADHD and 29 typically developing controls performed a simple Go/No-Go task under four different event-rate conditions. There was an accentuated quadratic relationship between event rate and Gaussian variability in the ADHD group compared to the controls. The children with ADHD had greater Gaussian variability at very fast and very slow event rates but not at moderate event rates. The results provide evidence for the SRD account of ADHD. However, given that this effect did not explain all group differences (some of which were independent of event rate) other cognitive and/or motivational processes are also likely implicated in ADHD performance deficits.

A Scalable Framework For Segmenting Magnetic Resonance Images

PubMed Central

Hore, Prodip; Goldgof, Dmitry B.; Gu, Yuhua; Maudsley, Andrew A.; Darkazanli, Ammar

2009-01-01

A fast, accurate and fully automatic method of segmenting magnetic resonance images of the human brain is introduced. The approach scales well allowing fast segmentations of fine resolution images. The approach is based on modifications of the soft clustering algorithm, fuzzy c-means, that enable it to scale to large data sets. Two types of modifications to create incremental versions of fuzzy c-means are discussed. They are much faster when compared to fuzzy c-means for medium to extremely large data sets because they work on successive subsets of the data. They are comparable in quality to application of fuzzy c-means to all of the data. The clustering algorithms coupled with inhomogeneity correction and smoothing are used to create a framework for automatically segmenting magnetic resonance images of the human brain. The framework is applied to a set of normal human brain volumes acquired from different magnetic resonance scanners using different head coils, acquisition parameters and field strengths. Results are compared to those from two widely used magnetic resonance image segmentation programs, Statistical Parametric Mapping and the FMRIB Software Library (FSL). The results are comparable to FSL while providing significant speed-up and better scalability to larger volumes of data. PMID:20046893

Endocrine Regulation of Bone and Energy Metabolism in Hibernating Mammals

PubMed Central

Doherty, Alison H.; Florant, Gregory L.; Donahue, Seth W.

2014-01-01

Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships between bone, fat, reproductive, and brain tissues have come to light. These systems share interconnected regulatory mechanisms of energy metabolism that potentially protect the skeleton during hibernation. This review focuses on the endocrine and neuroendocrine regulation of bone/fat/energy metabolism in hibernators. Hibernators appear to have unique mechanisms that protect musculoskeletal tissues while catabolizing their abundant stores of fat. Furthermore, the bone remodeling processes that normally cause disuse-induced bone loss in non-hibernators are compared to bone remodeling processes in hibernators, and possible adaptations of the bone signaling pathways that protect the skeleton during hibernation are discussed. Understanding the biological mechanisms that allow hibernators to survive the prolonged disuse and fasting associated with extreme environmental challenges will provide critical information regarding the limit of convergence in mammalian systems and of skeletal plasticity, and may contribute valuable insight into the etiology and treatment of human diseases. PMID:24556365

Adiabatic Quantum Search in Open Systems.

PubMed

Wild, Dominik S; Gopalakrishnan, Sarang; Knap, Michael; Yao, Norman Y; Lukin, Mikhail D

2016-10-07

Adiabatic quantum algorithms represent a promising approach to universal quantum computation. In isolated systems, a key limitation to such algorithms is the presence of avoided level crossings, where gaps become extremely small. In open quantum systems, the fundamental robustness of adiabatic algorithms remains unresolved. Here, we study the dynamics near an avoided level crossing associated with the adiabatic quantum search algorithm, when the system is coupled to a generic environment. At zero temperature, we find that the algorithm remains scalable provided the noise spectral density of the environment decays sufficiently fast at low frequencies. By contrast, higher order scattering processes render the algorithm inefficient at any finite temperature regardless of the spectral density, implying that no quantum speedup can be achieved. Extensions and implications for other adiabatic quantum algorithms will be discussed.

Ultrafast dynamics of colloidal semiconductor nanocrystals relevant to solar fuels production

NASA Astrophysics Data System (ADS)

Cogan, Nicole M. B.; Liu, Cunming; Qiu, Fen; Burke, Rebeckah; Krauss, Todd D.

2017-05-01

Artificial conversion of sunlight to chemical fuels has attracted attention for several decades as a potential source of clean, renewable energy. We recently found that CdSe quantum dots (QDs) and simple aqueous Ni2+ salts in the presence of a sacrificial electron donor form a highly efficient, active, and robust system for photochemical reduction of protons to molecular hydrogen. Ultrafast transient absorption spectroscopy studies of electron transfer (ET) processes from the QDs to the Ni catalysts reveal extremely fast ET, and provide a fundamental explanation for the exceptional photocatalytic H2 activity. Additionally, by studying H2 production of the Ni catalyst with CdSe/CdS nanoparticles of various structures, it was determined that surface charge density plays an important role in charge transfer and ultimately H2 production activity.

Fast automated analysis of strong gravitational lenses with convolutional neural networks.

PubMed

Hezaveh, Yashar D; Levasseur, Laurence Perreault; Marshall, Philip J

2017-08-30

Quantifying image distortions caused by strong gravitational lensing-the formation of multiple images of distant sources due to the deflection of their light by the gravity of intervening structures-and estimating the corresponding matter distribution of these structures (the 'gravitational lens') has primarily been performed using maximum likelihood modelling of observations. This procedure is typically time- and resource-consuming, requiring sophisticated lensing codes, several data preparation steps, and finding the maximum likelihood model parameters in a computationally expensive process with downhill optimizers. Accurate analysis of a single gravitational lens can take up to a few weeks and requires expert knowledge of the physical processes and methods involved. Tens of thousands of new lenses are expected to be discovered with the upcoming generation of ground and space surveys. Here we report the use of deep convolutional neural networks to estimate lensing parameters in an extremely fast and automated way, circumventing the difficulties that are faced by maximum likelihood methods. We also show that the removal of lens light can be made fast and automated using independent component analysis of multi-filter imaging data. Our networks can recover the parameters of the 'singular isothermal ellipsoid' density profile, which is commonly used to model strong lensing systems, with an accuracy comparable to the uncertainties of sophisticated models but about ten million times faster: 100 systems in approximately one second on a single graphics processing unit. These networks can provide a way for non-experts to obtain estimates of lensing parameters for large samples of data.

Harvesting Extremes of Time Domain Astrophysics in the 2020s and Beyond

NASA Astrophysics Data System (ADS)

Grindlay, Jonathan E.

2017-01-01

In this session we have touched on several examples of Extreme Transients -- Stellar Mergers, Fast Radio Bursts, Changing Look Quasars, Tidal Disruption Events, and Gravitational Wave Counterparts. Other key examples of the Extremes of Time Domain Astrophysics are, of course, Gamma Ray Bursts (both Short and Long), Super-luminous Supernovae, Black Hole X-ray Binary Outbursts (every ~50y?), Extreme Flares of Blazars, PeV Neutrinos, and many more. For all of these the ability for rapid followup with Gamma-ray, X-ray, optical, IR, radio imaging and spectroscopy is needed for exploring and understanding the underlying physics that extreme transients represent. We introduce two concepts for space-borne observatories that can do this: 1) a Time-domain Spectroscopic Observatory (TSO), proposed as Concept for a Probe-class mission devoted to TDA followup. TSO would be a 1.5-2m cold telescope in Geosynch orbit over LSST for imaging and spectroscopy (R = 5, 100, 3000) over the 0.4 - 5 micron band to finally enable use of GRBs as probes of the Early Universe and EoR out to z >10-12, as well as measures of the M-sigma relation from reverberation mapping of AGN flares for the growth of SMBHs in AGN out to z ~8 (and many other key projects); and 2) a 4pi (simultaneous) X-ray Imaging Observatory (4piXIO), as a Swarm of ~30 CubeSats (36U) each with 0.4sr FoV coded aperture telescopes with ~1arcmin resolution and ~10arcsec source positions to monitor all classes of transients and variable sources (0.3 - 200 keV) as well as provide 4pi coverage for GRBs to a TSO, for followup on a sample >10X that of Swift. We also introduce the newly-formed (2014) AAS Working Group on Time Domain Astronomy (WGTDA) and invite all with interests in this exciting and growing field to join and consider how TDA can best advance in the next Decade.

Lane change warning threshold based on driver perception characteristics.

PubMed

Wang, Chang; Sun, Qinyu; Fu, Rui; Li, Zhen; Zhang, Qiong

2018-08-01

Lane Change Warning system (LCW) is exploited to alleviate driver workload and improve the safety performance of lane changes. Depending on the secure threshold, the lane change warning system could transmit caution to drivers. Although the system possesses substantial benefits, it may perturb the conventional operating of the driver and affect driver judgment if the warning threshold does not conform to the driver perception of safety. Therefore, it is essential to establish an appropriate warning threshold to enhance the accuracy rate and acceptability of the lane change warning system. This research aims to identify the threshold that conforms to the driver perception of the ability to safely change lanes with a rear vehicle fast approaching. We propose a theoretical warning model of lane change based on a safe minimum distance and deceleration of the rear vehicle. For the purpose of acquiring the different safety levels of lane changes, 30 licensed drivers are recruited and we obtain the extreme moments represented by driver perception characteristics from a Front Extremity Test and a Rear Extremity Test implemented on the freeway. The required deceleration of the rear vehicle corresponding to the extreme time is calculated according to the proposed model. In light of discrepancies in the deceleration in these extremity experiments, we determine two levels of a hierarchical warning system. The purpose of the primary warning is to remind drivers of the existence of potentially dangerous vehicles and the second warning is used to warn the driver to stop changing lanes immediately. We use the signal detection theory to analyze the data. Ultimately, we confirm that the first deceleration threshold is 1.5 m/s 2 and the second deceleration threshold is 2.7 m/s 2 . The findings provide the basis for the algorithm design of LCW and enhance the acceptability of the intelligent system. Copyright © 2018 Elsevier Ltd. All rights reserved.

FAME: freeform active mirror experiment

NASA Astrophysics Data System (ADS)

Aitink-Kroes, Gabby; Agócs, Tibor; Miller, Chris; Black, Martin; Farkas, Szigfrid; Lemared, Sabri; Bettonvil, Felix; Montgomery, David; Marcos, Michel; Jaskó, Attila; van Duffelen, Farian; Challita, Zalpha; Fok, Sandy; Kiaeerad, Fatemeh; Hugot, Emmanuel; Schnetler, Hermine; Venema, Lars

2016-07-01

FAME is a four-year project and part of the OPTICON/FP7 program that is aimed at providing a breakthrough component for future compact, wide field, high resolution imagers or spectrographs, based on both Freeform technology, and the flexibility and versatility of active systems. Due to the opening of a new parameter space in optical design, Freeform Optics are a revolution in imaging systems for a broad range of applications from high tech cameras to astronomy, via earth observation systems, drones and defense. Freeform mirrors are defined by a non-rotational symmetry of the surface shape, and the fact that the surface shape cannot be simply described by conicoids extensions, or off-axis conicoids. An extreme freeform surface is a significantly challenging optical surface, especially for UV/VIS/NIR diffraction limited instruments. The aim of the FAME effort is to use an extreme freeform mirror with standard optics in order to propose an integrated system solution for use in future instruments. The work done so far concentrated on identification of compact, fast, widefield optical designs working in the visible, with diffraction limited performance; optimization of the number of required actuators and their layout; the design of an active array to manipulate the face sheet, as well as the actuator design. In this paper we present the status of the demonstrator development, with focus on the different building blocks: an extreme freeform thin face sheet, the active array, a highly controllable thermal actuator array, and the metrology and control system.

Flexible displays as key for high-value and unique automotive design

NASA Astrophysics Data System (ADS)

Isele, Robert

2011-03-01

Within the last few years' car industry changed very fast. Information and Communication became more important and displays are now standard in nearly every car. But this is not the only trend which could be recognized in this industry. CO2 emission, fuel price as well as the increasing traffic inside the Mega Cities initialized a big change in the behavior of the customers. The big battle for the car industry will enter the interior extremely fast, and the premium cars need ore innovative design icons. Flexible Displays are one big step that enables totally different designs and a new value of the driver experience.

A case of severe anorexia, excessive weight loss and high peptide YY levels after sleeve gastrectomy.

PubMed

Pucci, Andrea; Cheung, Wui Hang; Jones, Jenny; Manning, Sean; Kingett, Helen; Adamo, Marco; Elkalaawy, Mohamed; Jenkinson, Andrew; Finer, Nicholas; Doyle, Jacqueline; Hashemi, Majid; Batterham, Rachel L

2015-01-01

Sleeve gastrectomy (SG) is the second most commonly performed bariatric procedure worldwide. Altered circulating gut hormones have been suggested to contribute post-operatively to appetite suppression, decreased caloric intake and weight reduction. In the present study, we report a 22-year-old woman who underwent laparoscopic SG for obesity (BMI 46 kg/m(2)). Post-operatively, she reported marked appetite reduction, which resulted in excessive weight loss (1-year post-SG: BMI 22 kg/m(2), weight loss 52%, >99th centile of 1-year percentage of weight loss from 453 SG patients). Gastrointestinal (GI) imaging, GI physiology/motility studies and endoscopy revealed no anatomical cause for her symptoms, and psychological assessments excluded an eating disorder. Despite nutritional supplements and anti-emetics, her weight loss continued (BMI 19 kg/m(2)), and she required nasogastric feeding. A random gut hormone assessment revealed high plasma peptide YY (PYY) levels. She underwent a 3 h meal study following an overnight fast to assess her subjective appetite and circulating gut hormone levels. Her fasted nausea scores were high, with low hunger, and these worsened with nutrient ingestion. Compared to ten other post-SG female patients, her fasted circulating PYY and nutrient-stimulated PYY and active glucagon-like peptide 1 (GLP1) levels were markedly elevated. Octreotide treatment was associated with suppressed circulating PYY and GLP1 levels, increased appetite, increased caloric intake and weight gain (BMI 22 kg/m(2) after 6 months). The present case highlights the value of measuring gut hormones in patients following bariatric surgery who present with anorexia and excessive weight loss and suggests that octreotide treatment can produce symptomatic relief and weight regain in this setting. Roux-en-Y gastric bypass and SG produce marked sustained weight reduction. However, there is a marked individual variability in this reduction, and post-operative weight loss follows a normal distribution with extremes of 'good' and 'poor' response.Profound anorexia and excessive weight loss post-SG may be associated with markedly elevated circulating fasted PYY and post-meal PYY and GLP1 levels.Octreotide treatment can produce symptomatic relief and weight regain for post-SG patients that have an extreme anorectic and weight loss response.The present case highlights the value of measuring circulating gut hormone levels in patients with post-operative anorexia and extreme weight loss.

Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.

PubMed

MacLean, David M; Jayaraman, Vasanthi

2017-03-21

Acid-sensing ion channels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological range. Recent reports have revealed that postsynaptically localized ASICs contribute to the excitatory postsynaptic current by responding to the transient acidification of the synaptic cleft that accompanies neurotransmission. In response to such brief acidic transients, both recombinant and native ASICs show extremely rapid deactivation in outside-out patches when jumping from a pH 5 stimulus to a single resting pH of 8. Given that the resting pH of the synaptic cleft is highly dynamic and depends on recent synaptic activity, we explored the kinetics of ASIC1a and 1a/2a heteromers to such brief pH transients over a wider [H + ] range to approximate neuronal conditions better. Surprisingly, the deactivation of ASICs was steeply dependent on the pH, spanning nearly three orders of magnitude from extremely fast (<1 ms) at pH 8 to very slow (>300 ms) at pH 7. This study provides an example of a ligand-gated ion channel whose deactivation is sensitive to agonist concentrations that do not directly activate the receptor. Kinetic simulations and further mutagenesis provide evidence that ASICs show such steeply agonist-dependent deactivation because of strong cooperativity in proton binding. This capacity to signal across such a large synaptically relevant bandwidth enhances the response to small-amplitude acidifications likely to occur at the cleft and may provide ASICs with the ability to shape activity in response to the recent history of the synapse.

Extremely rapid directional change during Matuyama-Brunhes geomagnetic polarity reversal

NASA Astrophysics Data System (ADS)

Sagnotti, Leonardo; Scardia, Giancarlo; Giaccio, Biagio; Liddicoat, Joseph C.; Nomade, Sebastien; Renne, Paul R.; Sprain, Courtney J.

2014-11-01

We report a palaeomagnetic investigation of the last full geomagnetic field reversal, the Matuyama-Brunhes (M-B) transition, as preserved in a continuous sequence of exposed lacustrine sediments in the Apennines of Central Italy. The palaeomagnetic record provides the most direct evidence for the tempo of transitional field behaviour yet obtained for the M-B transition. 40Ar/39Ar dating of tephra layers bracketing the M-B transition provides high-accuracy age constraints and indicates a mean sediment accumulation rate of about 0.2 mm yr-1 during the transition. Two relative palaeointensity (RPI) minima are present in the M-B transition. During the terminus of the upper RPI minimum, a directional change of about 180 ° occurred at an extremely fast rate, estimated to be less than 2 ° per year, with no intermediate virtual geomagnetic poles (VGPs) documented during the transit from the southern to northern hemisphere. Thus, the entry into the Brunhes Normal Chron as represented by the palaeomagnetic directions and VGPs developed in a time interval comparable to the duration of an average human life, which is an order of magnitude more rapid than suggested by current models. The reported investigation therefore provides high-resolution integrated palaeomagnetic and radioisotopic data that document the fine details of the anatomy and tempo of the M-B transition in Central Italy that in turn are crucial for a better understanding of Earth's magnetic field, and for the development of more sophisticated models that are able to describe its global structure and behaviour.

fastBMA: scalable network inference and transitive reduction.

PubMed

Hung, Ling-Hong; Shi, Kaiyuan; Wu, Migao; Young, William Chad; Raftery, Adrian E; Yeung, Ka Yee

2017-10-01

Inferring genetic networks from genome-wide expression data is extremely demanding computationally. We have developed fastBMA, a distributed, parallel, and scalable implementation of Bayesian model averaging (BMA) for this purpose. fastBMA also includes a computationally efficient module for eliminating redundant indirect edges in the network by mapping the transitive reduction to an easily solved shortest-path problem. We evaluated the performance of fastBMA on synthetic data and experimental genome-wide time series yeast and human datasets. When using a single CPU core, fastBMA is up to 100 times faster than the next fastest method, LASSO, with increased accuracy. It is a memory-efficient, parallel, and distributed application that scales to human genome-wide expression data. A 10 000-gene regulation network can be obtained in a matter of hours using a 32-core cloud cluster (2 nodes of 16 cores). fastBMA is a significant improvement over its predecessor ScanBMA. It is more accurate and orders of magnitude faster than other fast network inference methods such as the 1 based on LASSO. The improved scalability allows it to calculate networks from genome scale data in a reasonable time frame. The transitive reduction method can improve accuracy in denser networks. fastBMA is available as code (M.I.T. license) from GitHub (https://github.com/lhhunghimself/fastBMA), as part of the updated networkBMA Bioconductor package (https://www.bioconductor.org/packages/release/bioc/html/networkBMA.html) and as ready-to-deploy Docker images (https://hub.docker.com/r/biodepot/fastbma/). © The Authors 2017. Published by Oxford University Press.

An extreme magneto-ionic environment associated with the fast radio burst source FRB 121102

NASA Astrophysics Data System (ADS)

Michilli, D.; Seymour, A.; Hessels, J. W. T.; Spitler, L. G.; Gajjar, V.; Archibald, A. M.; Bower, G. C.; Chatterjee, S.; Cordes, J. M.; Gourdji, K.; Heald, G. H.; Kaspi, V. M.; Law, C. J.; Sobey, C.; Adams, E. A. K.; Bassa, C. G.; Bogdanov, S.; Brinkman, C.; Demorest, P.; Fernandez, F.; Hellbourg, G.; Lazio, T. J. W.; Lynch, R. S.; Maddox, N.; Marcote, B.; McLaughlin, M. A.; Paragi, Z.; Ransom, S. M.; Scholz, P.; Siemion, A. P. V.; Tendulkar, S. P.; van Rooy, P.; Wharton, R. S.; Whitlow, D.

2018-01-01

Fast radio bursts are millisecond-duration, extragalactic radio flashes of unknown physical origin. The only known repeating fast radio burst source—FRB 121102—has been localized to a star-forming region in a dwarf galaxy at redshift 0.193 and is spatially coincident with a compact, persistent radio source. The origin of the bursts, the nature of the persistent source and the properties of the local environment are still unclear. Here we report observations of FRB 121102 that show almost 100 per cent linearly polarized emission at a very high and variable Faraday rotation measure in the source frame (varying from +1.46 × 105 radians per square metre to +1.33 × 105 radians per square metre at epochs separated by seven months) and narrow (below 30 microseconds) temporal structure. The large and variable rotation measure demonstrates that FRB 121102 is in an extreme and dynamic magneto-ionic environment, and the short durations of the bursts suggest a neutron star origin. Such large rotation measures have hitherto been observed only in the vicinities of massive black holes (larger than about 10,000 solar masses). Indeed, the properties of the persistent radio source are compatible with those of a low-luminosity, accreting massive black hole. The bursts may therefore come from a neutron star in such an environment or could be explained by other models, such as a highly magnetized wind nebula or supernova remnant surrounding a young neutron star.

Bone characteristics of late-term embryonic and hatchling broilers: bone development under extreme growth rate.

PubMed

Yair, R; Uni, Z; Shahar, R

2012-10-01

The development of broilers is an extreme example of rapid growth, increasing in weight from 40 g at hatch to 2,000 g 5 to 6 wk later. Such rapid growth requires a correspondingly fast development of the skeleton. Bone development is a genetically programmed process that is modified by epigenetic factors, mainly muscle-induced stresses and strains. In this study, we describe the temporal changes in bone morphology and material properties during the prehatch period [embryonic day (E) 14, E17, E19, E21] and posthatch d 3 and 7. The bones were examined for their weight, length, ash content, mechanical properties, and cortical structure. We show that the cross-sectional shape of the tibia and femur changes during the examination period from circular to elliptical. Additionally, the changes in bone properties are time-dependent and nonuniform: from E14 to E17 and from d 3 to 7, fast bone growth was noted, with major increases in both mechanical properties (stiffness, ultimate load, and energy to fracture) and geometric properties (cross-sectional area and thickness, medullary area, and moment of inertia). On the other hand, during the last days of incubation, most mechanical and geometric properties remain unchanged or even decrease. The reasons for this finding may relate to the hatching process but also to mineral shortage during the last days of incubation. This study leads to better understanding of bone development in ovo and posthatch in fast-growing broilers.

An extreme magneto-ionic environment associated with the fast radio burst source FRB 121102.

PubMed

Michilli, D; Seymour, A; Hessels, J W T; Spitler, L G; Gajjar, V; Archibald, A M; Bower, G C; Chatterjee, S; Cordes, J M; Gourdji, K; Heald, G H; Kaspi, V M; Law, C J; Sobey, C; Adams, E A K; Bassa, C G; Bogdanov, S; Brinkman, C; Demorest, P; Fernandez, F; Hellbourg, G; Lazio, T J W; Lynch, R S; Maddox, N; Marcote, B; McLaughlin, M A; Paragi, Z; Ransom, S M; Scholz, P; Siemion, A P V; Tendulkar, S P; Van Rooy, P; Wharton, R S; Whitlow, D

2018-01-10

Fast radio bursts are millisecond-duration, extragalactic radio flashes of unknown physical origin. The only known repeating fast radio burst source-FRB 121102-has been localized to a star-forming region in a dwarf galaxy at redshift 0.193 and is spatially coincident with a compact, persistent radio source. The origin of the bursts, the nature of the persistent source and the properties of the local environment are still unclear. Here we report observations of FRB 121102 that show almost 100 per cent linearly polarized emission at a very high and variable Faraday rotation measure in the source frame (varying from +1.46 × 10 5 radians per square metre to +1.33 × 10 5 radians per square metre at epochs separated by seven months) and narrow (below 30 microseconds) temporal structure. The large and variable rotation measure demonstrates that FRB 121102 is in an extreme and dynamic magneto-ionic environment, and the short durations of the bursts suggest a neutron star origin. Such large rotation measures have hitherto been observed only in the vicinities of massive black holes (larger than about 10,000 solar masses). Indeed, the properties of the persistent radio source are compatible with those of a low-luminosity, accreting massive black hole. The bursts may therefore come from a neutron star in such an environment or could be explained by other models, such as a highly magnetized wind nebula or supernova remnant surrounding a young neutron star.

[Applications and connected objects, new perspectives].

PubMed

Trudelle, Pierre

2017-11-01

Applications and connected objects appear promising in the world of wellbeing and health. Often cheap, they offer numerous perspectives for health promotion, in targeted fields or to fulfil 'niche' needs. This growth, extremely fast over the last five years, has also given rise to potential defiance on the part of users. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

The record-breaking 2012 spring: Why degree-days were critical in assessing insect and plant development

USDA-ARS?s Scientific Manuscript database

In the spring of 2012, extremely high temperatures were recorded in the upper Midwest during the month of March. This sustained heat wave not only made March the warmest on record, but also induced remarkably fast development of arthropods and plants. In terms of degree-days, however, the arthropod ...

The warm winter and spring of 2012: Why degree-days were critical in measuring insect and plant development

USDA-ARS?s Scientific Manuscript database

In the spring of 2012, extremely high temperatures were recorded in the upper Midwest during the month of March. This sustained heat wave not only made March the warmest on record, but also induced remarkably fast development of arthropods and plants. In terms of degree-days, however, the arthropod ...

High contrast stellar observations within the diffraction limit at the Palomar Hale telescope

NASA Astrophysics Data System (ADS)

Mennesson, B.; Hanot, C.; Serabyn, E.; Martin, S. R.; Liewer, K.; Loya, F.; Mawet, D.

2010-07-01

We report on high-accuracy, high-resolution (< 20mas) stellar measurements obtained in the near infrared ( 2.2 microns) at the Palomar 200 inch telescope using two elliptical (3m x 1.5m) sub-apertures located 3.4m apart. Our interferometric coronagraph, known as the "Palomar Fiber Nuller" (PFN), is located downstream of the Palomar adaptive optics (AO) system and recombines the two separate beams into a common singlemode fiber. The AO system acts as a "fringe tracker", maintaining the optical path difference (OPD) between the beams around an adjustable value, which is set to the central dark interference fringe. AO correction ensures high efficiency and stable injection of the beams into the single-mode fiber. A chopper wheel and a fast photometer are used to record short (< 50ms per beam) interleaved sequences of background, individual beam and interferometric signals. In order to analyze these chopped null data sequences, we developed a new statistical method, baptized "Null Self-Calibration" (NSC), which provides astrophysical null measurements at the 0.001 level, with 1 σ uncertainties as low as 0.0003. Such accuracy translates into a dynamic range greater than 1000:1 within the diffraction limit, demonstrating that the approach effectively bridges the traditional gap between regular coronagraphs, limited in angular resolution, and long baseline visibility interferometers, whose dynamic range is restricted to 100:1. As our measurements are extremely sensitive to the brightness distribution very close to the optical axis, we were able to constrain the stellar diameters and amounts of circumstellar emission for a sample of very bright stars. With the improvement expected when the PALM-3000 extreme AO system comes on-line at Palomar, the same instrument now equipped with a state of the art low noise fast read-out near IR camera, will yield 10-4 to 10-3 contrast as close as 30 mas for stars with K magnitude brighter than 6. Such a system will provide a unique and ideal tool for the detection of young (<100 Myr) self-luminous planets and hot debris disks in the immediate vicinity (0.1 to a few AUs) of nearby (< 50pc) stars.

A fast, preconditioned conjugate gradient Toeplitz solver

NASA Technical Reports Server (NTRS)

Pan, Victor; Schrieber, Robert

1989-01-01

A simple factorization is given of an arbitrary hermitian, positive definite matrix in which the factors are well-conditioned, hermitian, and positive definite. In fact, given knowledge of the extreme eigenvalues of the original matrix A, an optimal improvement can be achieved, making the condition numbers of each of the two factors equal to the square root of the condition number of A. This technique is to applied to the solution of hermitian, positive definite Toeplitz systems. Large linear systems with hermitian, positive definite Toeplitz matrices arise in some signal processing applications. A stable fast algorithm is given for solving these systems that is based on the preconditioned conjugate gradient method. The algorithm exploits Toeplitz structure to reduce the cost of an iteration to O(n log n) by applying the fast Fourier Transform to compute matrix-vector products. Matrix factorization is used as a preconditioner.

Rapid, High-Throughput Tracking of Bacterial Motility in 3D via Phase-Contrast Holographic Video Microscopy

PubMed Central

Cheong, Fook Chiong; Wong, Chui Ching; Gao, YunFeng; Nai, Mui Hoon; Cui, Yidan; Park, Sungsu; Kenney, Linda J.; Lim, Chwee Teck

2015-01-01

Tracking fast-swimming bacteria in three dimensions can be extremely challenging with current optical techniques and a microscopic approach that can rapidly acquire volumetric information is required. Here, we introduce phase-contrast holographic video microscopy as a solution for the simultaneous tracking of multiple fast moving cells in three dimensions. This technique uses interference patterns formed between the scattered and the incident field to infer the three-dimensional (3D) position and size of bacteria. Using this optical approach, motility dynamics of multiple bacteria in three dimensions, such as speed and turn angles, can be obtained within minutes. We demonstrated the feasibility of this method by effectively tracking multiple bacteria species, including Escherichia coli, Agrobacterium tumefaciens, and Pseudomonas aeruginosa. In addition, we combined our fast 3D imaging technique with a microfluidic device to present an example of a drug/chemical assay to study effects on bacterial motility. PMID:25762336

Fast, Deep-Record-Length, Fiber-Coupled Photodiode Imaging Array for Plasma Diagnostics

NASA Astrophysics Data System (ADS)

Brockington, Samuel; Case, Andrew; Witherspoon, F. Douglas

2014-10-01

HyperV Technologies has been developing an imaging diagnostic comprised of an array of fast, low-cost, long-record-length, fiber-optically-coupled photodiode channels to investigate plasma dynamics and other fast, bright events. By coupling an imaging fiber bundle to a bank of amplified photodiode channels, imagers and streak imagers of 100 to 1000 pixels can be constructed. By interfacing analog photodiode systems directly to commercial analog-to-digital converters and modern memory chips, a prototype 100 pixel array with an extremely deep record length (128 k points at 20 Msamples/s) and 10 bit pixel resolution has already been achieved. HyperV now seeks to extend these techniques to construct a prototype 1000 Pixel framing camera with up to 100 Msamples/sec rate and 10 to 12 bit depth. Preliminary experimental results as well as Phase 2 plans will be discussed. Work supported by USDOE Phase 2 SBIR Grant DE-SC0009492.

SHIELD: EVLA HI Spectral Line Observations of Low-mass Dwarfs

NASA Astrophysics Data System (ADS)

Miazzo, Masao; Ruvolo, Elizabeth; Cannon, John M.; McNichols, Andrew; Teich, Yaron; Adams, Elizabeth A.; Giovanelli, Riccardo; Haynes, Martha P.; McQuinn, Kristen B.; Salzer, John Joseph; Skillman, Evan D.; Dolphin, Andrew E.; Elson, Edward C.; Haurberg, Nathalie C.; Huang, Shan; Janowiecki, Steven; Jozsa, Gyula; Leisman, Luke; Ott, Juergen; Papastergis, Emmanouil; Rhode, Katherine L.; Saintonge, Amelie; Van Sistine, Angela; Warren, Steven R.

2017-01-01

The “Survey of HI in Extremely Low-mass Dwarfs” (SHIELD) is a multiwavelength study of local volume low-mass galaxies. Using the now-complete Arecibo Legacy Fast ALFA (ALFALFA) source catalog, 82 systems are identified that meet distance, line width, and HI flux criteria for being gas-rich, low-mass galaxies. These systems harbor neutral gas reservoirs smaller than 3x10^7 M_sun, thus populating the faint end of the HI mass function with statistical confidence for the first time. Here we present new Karl G. Jansky Very Large Array D-configuration HI spectral line observations of 32 previously unobserved galaxies. These low angular resolution (~40" beam) images localize the HI gas; with a few exceptions, the HI gas is co-spatial with the optical centers of the galaxies. These images provide the first glimpse of the neutral interstellar medium in these systems.Support for this work was provided by NSF grant 1211683 to JMC at Macalester College.

Mesoscopic chaos mediated by Drude electron-hole plasma in silicon optomechanical oscillators

PubMed Central

Wu, Jiagui; Huang, Shu-Wei; Huang, Yongjun; Zhou, Hao; Yang, Jinghui; Liu, Jia-Ming; Yu, Mingbin; Lo, Guoqiang; Kwong, Dim-Lee; Duan, Shukai; Wei Wong, Chee

2017-01-01

Chaos has revolutionized the field of nonlinear science and stimulated foundational studies from neural networks, extreme event statistics, to physics of electron transport. Recent studies in cavity optomechanics provide a new platform to uncover quintessential architectures of chaos generation and the underlying physics. Here, we report the generation of dynamical chaos in silicon-based monolithic optomechanical oscillators, enabled by the strong and coupled nonlinearities of two-photon absorption induced Drude electron–hole plasma. Deterministic chaotic oscillation is achieved, and statistical and entropic characterization quantifies the chaos complexity at 60 fJ intracavity energies. The correlation dimension D2 is determined at 1.67 for the chaotic attractor, along with a maximal Lyapunov exponent rate of about 2.94 times the fundamental optomechanical oscillation for fast adjacent trajectory divergence. Nonlinear dynamical maps demonstrate the subharmonics, bifurcations and stable regimes, along with distinct transitional routes into chaos. This provides a CMOS-compatible and scalable architecture for understanding complex dynamics on the mesoscopic scale. PMID:28598426

Direct-Y: Fast Acquisition of the GPS PPS Signal

NASA Technical Reports Server (NTRS)

Namoos, Omar M.; DiEsposti, Raymond S.

1996-01-01

The NAVSTAR Global Positioning System (GPS) provides positioning and time information to military users via the Precise Positioning Service (PPS) which typically allows users a significant margin of precision over the commercially available Standard Positioning Service (SPS), Military sets that rely on first acquiring the SPS Coarse Acquisition (C/A) code, read from the data message the handover word (HOW) that provides the time-of-signal transmission needed to acquire and lock onto the PPS Y-code. Under extreme battlefield conditions, the use of GPS would be denied to the warfighter who cannot pick up the un-encrypted C/A code. Studies are underway at the GPS Joint Program Office (JPO) at the Space and Missile Center, Los Angeles Air Force Base that are aimed at developing the capability to directly acquire Y-code without first acquiring C/A code. This paper briefly outlines efforts to develop 'direct-Y' acquisition, and various approaches to solving this problem. The potential ramifications of direct-Y to military users are also discussed.

A hybrid fuzzy logic and extreme learning machine for improving efficiency of circulating water systems in power generation plant

NASA Astrophysics Data System (ADS)

Aziz, Nur Liyana Afiqah Abdul; Siah Yap, Keem; Afif Bunyamin, Muhammad

2013-06-01

This paper presents a new approach of the fault detection for improving efficiency of circulating water system (CWS) in a power generation plant using a hybrid Fuzzy Logic System (FLS) and Extreme Learning Machine (ELM) neural network. The FLS is a mathematical tool for calculating the uncertainties where precision and significance are applied in the real world. It is based on natural language which has the ability of "computing the word". The ELM is an extremely fast learning algorithm for neural network that can completed the training cycle in a very short time. By combining the FLS and ELM, new hybrid model, i.e., FLS-ELM is developed. The applicability of this proposed hybrid model is validated in fault detection in CWS which may help to improve overall efficiency of power generation plant, hence, consuming less natural recourses and producing less pollutions.

Random sampling technique for ultra-fast computations of molecular opacities for exoplanet atmospheres

NASA Astrophysics Data System (ADS)

Min, M.

2017-10-01

Context. Opacities of molecules in exoplanet atmospheres rely on increasingly detailed line-lists for these molecules. The line lists available today contain for many species up to several billions of lines. Computation of the spectral line profile created by pressure and temperature broadening, the Voigt profile, of all of these lines is becoming a computational challenge. Aims: We aim to create a method to compute the Voigt profile in a way that automatically focusses the computation time into the strongest lines, while still maintaining the continuum contribution of the high number of weaker lines. Methods: Here, we outline a statistical line sampling technique that samples the Voigt profile quickly and with high accuracy. The number of samples is adjusted to the strength of the line and the local spectral line density. This automatically provides high accuracy line shapes for strong lines or lines that are spectrally isolated. The line sampling technique automatically preserves the integrated line opacity for all lines, thereby also providing the continuum opacity created by the large number of weak lines at very low computational cost. Results: The line sampling technique is tested for accuracy when computing line spectra and correlated-k tables. Extremely fast computations ( 3.5 × 105 lines per second per core on a standard current day desktop computer) with high accuracy (≤1% almost everywhere) are obtained. A detailed recipe on how to perform the computations is given.

Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents123

PubMed Central

Misra, Madhusmita; Katzman, Debra K; Cord, Jennalee; Manning, Stephanie J; Mickley, Diane; Herzog, David B; Miller, Karen K; Klibanski, Anne

2013-01-01

Background Anorexia nervosa (AN) is a condition of severe undernutrition associated with altered regional fat distribution in females. Although primarily a disease of females, AN is increasingly being recognized in males and is associated with hypogonadism. Testosterone is a major regulator of body composition in males, and testosterone administration in adults decreases visceral fat. However, the effect of low testosterone and other hormonal alterations on body composition in boys with AN is not known. Objective We hypothesized that testosterone deficiency in boys with AN is associated with higher trunk fat, as opposed to extremity fat, compared with control subjects. Design We assessed body composition using dual-energy X-ray absorptiometry and measured fasting testosterone, estradiol, insulin-like growth factor-1, leptin, and active ghrelin concentrations in 15 boys with AN and in 15 control subjects of comparable maturity aged 12–19 y. Results Fat and lean mass in AN boys was 69% and 86% of that in control subjects. Percentage extremity fat and extremity lean mass were lower in boys with AN (P = 0.003 and 0.0008); however, percentage trunk fat and the trunk to extremity fat ratio were higher after weight was adjusted for (P = 0.005 and 0.003). Testosterone concentrations were lower in boys with AN, and, on regression modeling, positively predicted percentage extremity lean mass and inversely predicted percentage trunk fat and trunk to extremity fat ratio. Other independent predictors of regional body composition were bone age and weight. Conclusions In adolescent boys with AN, higher percentage trunk fat, higher trunk to extremity fat ratio, lower percentage extremity fat, and lower extremity lean mass (adjusted for weight) are related to the hypogonadal state. PMID:19064506

Cosmic ray air shower characteristics in the framework of the parton-based Gribov-Regge model NEXUS

NASA Astrophysics Data System (ADS)

Bossard, G.; Drescher, H. J.; Kalmykov, N. N.; Ostapchenko, S.; Pavlov, A. I.; Pierog, T.; Vishnevskaya, E. A.; Werner, K.

2001-03-01

The purpose of this paper is twofold: first we want to introduce a new type of hadronic interaction model (NEXUS), which has a much more solid theoretical basis than, for example, presently used models such as QGSJET and VENUS, and ensures therefore a much more reliable extrapolation towards high energies. Secondly, we want to promote an extensive air shower (EAS) calculation scheme, based on cascade equations rather than explicit Monte Carlo simulations, which is very accurate in calculations of main EAS characteristics and extremely fast concerning computing time. We employ the NEXUS model to provide the necessary data on particle production in hadron-air collisions and present the average EAS characteristics for energies 1014-1017 eV. The experimental data of the CASA-BLANCA group are analyzed in the framework of the new model.

A generalized Condat's algorithm of 1D total variation regularization

NASA Astrophysics Data System (ADS)

Makovetskii, Artyom; Voronin, Sergei; Kober, Vitaly

2017-09-01

A common way for solving the denosing problem is to utilize the total variation (TV) regularization. Many efficient numerical algorithms have been developed for solving the TV regularization problem. Condat described a fast direct algorithm to compute the processed 1D signal. Also there exists a direct algorithm with a linear time for 1D TV denoising referred to as the taut string algorithm. The Condat's algorithm is based on a dual problem to the 1D TV regularization. In this paper, we propose a variant of the Condat's algorithm based on the direct 1D TV regularization problem. The usage of the Condat's algorithm with the taut string approach leads to a clear geometric description of the extremal function. Computer simulation results are provided to illustrate the performance of the proposed algorithm for restoration of degraded signals.

Three-dimensional near-field MIMO array imaging using range migration techniques.

PubMed

Zhuge, Xiaodong; Yarovoy, Alexander G

2012-06-01

This paper presents a 3-D near-field imaging algorithm that is formulated for 2-D wideband multiple-input-multiple-output (MIMO) imaging array topology. The proposed MIMO range migration technique performs the image reconstruction procedure in the frequency-wavenumber domain. The algorithm is able to completely compensate the curvature of the wavefront in the near-field through a specifically defined interpolation process and provides extremely high computational efficiency by the application of the fast Fourier transform. The implementation aspects of the algorithm and the sampling criteria of a MIMO aperture are discussed. The image reconstruction performance and computational efficiency of the algorithm are demonstrated both with numerical simulations and measurements using 2-D MIMO arrays. Real-time 3-D near-field imaging can be achieved with a real-aperture array by applying the proposed MIMO range migration techniques.

Inverse lithography using sparse mask representations

NASA Astrophysics Data System (ADS)

Ionescu, Radu C.; Hurley, Paul; Apostol, Stefan

2015-03-01

We present a novel optimisation algorithm for inverse lithography, based on optimization of the mask derivative, a domain inherently sparse, and for rectilinear polygons, invertible. The method is first developed assuming a point light source, and then extended to general incoherent sources. What results is a fast algorithm, producing manufacturable masks (the search space is constrained to rectilinear polygons), and flexible (specific constraints such as minimal line widths can be imposed). One inherent trick is to treat polygons as continuous entities, thus making aerial image calculation extremely fast and accurate. Requirements for mask manufacturability can be integrated in the optimization without too much added complexity. We also explain how to extend the scheme for phase-changing mask optimization.

Classification of large-sized hyperspectral imagery using fast machine learning algorithms

NASA Astrophysics Data System (ADS)

Xia, Junshi; Yokoya, Naoto; Iwasaki, Akira

2017-07-01

We present a framework of fast machine learning algorithms in the context of large-sized hyperspectral images classification from the theoretical to a practical viewpoint. In particular, we assess the performance of random forest (RF), rotation forest (RoF), and extreme learning machine (ELM) and the ensembles of RF and ELM. These classifiers are applied to two large-sized hyperspectral images and compared to the support vector machines. To give the quantitative analysis, we pay attention to comparing these methods when working with high input dimensions and a limited/sufficient training set. Moreover, other important issues such as the computational cost and robustness against the noise are also discussed.

[The 18F-FDG myocardial metabolic imaging in twenty seven pilots with regular aerobic training].

PubMed

Fang, Ting-Zheng; Zhu, Jia-Rui; Chuan, Ling; Zhao, Wen-Rui; Xu, Gen-Xiang; Yang, Min-Fu; He, Zuo-Xiang

2009-02-01

To evaluate the characteristics of myocardial (18)F-FDG imaging in pilots with regular aerobic exercise training. Twenty seven healthy male pilots with regular aerobic exercise training were included in this study. The subjects were divided into fasting (n = 17) or non-fasting group (n = 10). Fluorine-18-labeled deoxyglucose and Tc-99m-sestamibi dual-nuclide myocardial imaging were obtained at rest and at target heart rate during bicycle ergometer test. The exercise and rest myocardial perfusion imaging were analyzed for myocardial ischemia presence. The myocardial metabolism imaging was analyzed with the visual semi-quantitative analyses model of seventeen segments. The secondary-extreme heart rate (195-age) was achieved in all subjects. There was no myocardial ischemia in all perfusion imaging. In the visual qualitative analyses, four myocardial metabolism imaging failed in the fasting group while one failed in the non-fasting group (P > 0.05). In the visual semi-quantitative analyses, myocardial metabolism imaging scores at rest or exercise in all segments were similar between two groups (P > 0.05). In the fasting group, the myocardial metabolism imaging scores during exercise were significantly higher than those at rest in 6 segments (P < 0.05). In the non-fasting group, the scores of 3 exercise myocardial metabolism imaging were significantly higher than those at rest (P < 0.05). Satisfactory high-quality myocardial metabolism imaging could be obtained at fasting and exercise situations in subjects with regular aerobic exercise.

The rise of the mediocre forest: why chronically stressed trees may better survive extreme episodic climate variability

Treesearch

Steven G. McNulty; Johnny L. Boggs; Ge Sun

2014-01-01

Anthropogenic climate change is a relatively new phenomenon, largely occurring over the past 150 years, and much of the discussion on climate change impacts to forests has focused on long-term shifts in temperature and precipitation. However, individual trees respond to the much shorter impacts of climate variability. Historically, fast growing, fully canopied, non-...

Childhood Obesity: A Heavy Problem

ERIC Educational Resources Information Center

Costley, Kevin C.; Leggett, Timothy

2010-01-01

The youth of today are faced with a big problem; they are becoming more obese every day. The time of children playing outside all day and being extremely active has been overtaken by the television and video games. The days of sitting down as a family and eating a good healthy meal has been replaced by the rush to the nearest fast food…

Polar Science Is Cool!

ERIC Educational Resources Information Center

Weeks, Sophie

2012-01-01

Children are fascinated by the fact that polar scientists do research in extremely cold and dangerous places. In the Arctic they might be viewed as lunch by a polar bear. In the Antarctic, they could lose toes and fingers to frostbite and the wind is so fast it can rip skin off. They camp on ice in continuous daylight, weeks from any form of…

A C-Te-based binary OTS device exhibiting excellent performance and high thermal stability for selector application.

PubMed

Chekol, Solomon Amsalu; Yoo, Jongmyung; Park, Jaehyuk; Song, Jeonghwan; Sung, Changhyuck; Hwang, Hyunsang

2018-08-24

In this letter, we demonstrate a new binary ovonic threshold switching (OTS) selector device scalable down to ø30 nm based on C-Te. Our proposed selector device exhibits outstanding performance such as a high switching ratio (I on /I off  > 10 5 ), an extremely low off-current (∼1 nA), an extremely fast operating speed of <10 ns (transition time of <2 ns and delay time of <8 ns), high endurance (10 9 ), and high thermal stability (>450 °C). The observed high thermal stability is caused by the relatively small atomic size of C, compared to Te, which can effectively suppress the segregation and crystallization of Te in the OTS film. Furthermore, to confirm the functionality of the selector in a crossbar array, we evaluated a 1S-1R device by integrating our OTS device with a ReRAM (resistive random access memory) device. The 1S-1R integrated device exhibits a successful suppression of leakage current at the half-selected cell and shows an excellent read-out margin (>2 12 word lines) in a fast read operation.

Intracellular Adenosine Triphosphate Delivery Enhanced Skin Wound Healing in Rabbits

PubMed Central

Wang, Jianpu; Zhang, Qunwei; Wan, Rong; Mo, Yiqun; Li, Ming; Tseng, Michael T.; Chien, Sufan

2016-01-01

Small unilamellar lipid vesicles were used to encapsulate adenosine triphosphate (ATP-vesicles) for intracellular energy delivery. This technique was tested in full-thickness skin wounds in 16 adult rabbits. One ear was rendered ischemic by using a minimally invasive surgery. The other ear served as a normal control. Four circular full-thickness wounds were created on the ventral side of each ear. ATP-vesicles or saline was used and the wounds were covered with Tegaderm (3M, St. Paul, MN). Dressing was changed and digital photos were taken daily until all the wounds were healed. The mean healing times of ATP-vesicles–treated wounds were significantly shorter than that of saline-treated wounds on ischemic and nonischemic ears. Histologic study indicated better-developed granular tissue and reepithelial-ization in the ATP-vesicles–treated wounds. The wounds treated by ATP-vesicles exhibited extremely fast granular tissue growth. More CD31 positive cells were seen in the ATP-vesicles–treated wounds. This preliminary study shows that direct intracellular delivery of ATP can accelerate the healing process of skin wounds on ischemic and nonischemic rabbit ears. The extremely fast granular tissue growth was something never seen or reported in the past. PMID:19158531

Secrets of virtuoso: neuromuscular attributes of motor virtuosity in expert musicians

PubMed Central

Furuya, Shinichi; Oku, Takanori; Miyazaki, Fumio; Kinoshita, Hiroshi

2015-01-01

Musical performance requires extremely fast and dexterous limb movements. The underlying biological mechanisms have been an object of interest among scientists and non-scientists for centuries. Numerous studies of musicians and non-musicians have demonstrated that neuroplastic adaptations through early and deliberate musical training endowed superior motor skill. However, little has been unveiled about what makes inter-individual differences in motor skills among musicians. Here we determined the attributes of inter-individual differences in the maximum rate of repetitive piano keystrokes in twenty-four pianists. Among various representative factors of neuromuscular functions, anatomical characteristics, and training history, a stepwise multiple regression analysis and generalized linear model identified two predominant predictors of the maximum rate of repetitive piano keystrokes; finger tapping rate and muscular strength of the elbow extensor. These results suggest a non-uniform role of individual limb muscles in the production of extremely fast repetitive multi-joint movements. Neither age of musical training initiation nor the amount of extensive musical training before age twenty was a predictor. Power grip strength was negatively related to the maximum rate of piano keystrokes only during the smallest tone production. These findings highlight the importance of innate biological nature and explicit training for motor virtuosity. PMID:26502770

Application of a fast skyline computation algorithm for serendipitous searching problems

NASA Astrophysics Data System (ADS)

Koizumi, Kenichi; Hiraki, Kei; Inaba, Mary

2018-02-01

Skyline computation is a method of extracting interesting entries from a large population with multiple attributes. These entries, called skyline or Pareto optimal entries, are known to have extreme characteristics that cannot be found by outlier detection methods. Skyline computation is an important task for characterizing large amounts of data and selecting interesting entries with extreme features. When the population changes dynamically, the task of calculating a sequence of skyline sets is called continuous skyline computation. This task is known to be difficult to perform for the following reasons: (1) information of non-skyline entries must be stored since they may join the skyline in the future; (2) the appearance or disappearance of even a single entry can change the skyline drastically; (3) it is difficult to adopt a geometric acceleration algorithm for skyline computation tasks with high-dimensional datasets. Our new algorithm called jointed rooted-tree (JR-tree) manages entries using a rooted tree structure. JR-tree delays extend the tree to deep levels to accelerate tree construction and traversal. In this study, we presented the difficulties in extracting entries tagged with a rare label in high-dimensional space and the potential of fast skyline computation in low-latency cell identification technology.

Secrets of virtuoso: neuromuscular attributes of motor virtuosity in expert musicians

NASA Astrophysics Data System (ADS)

Furuya, Shinichi; Oku, Takanori; Miyazaki, Fumio; Kinoshita, Hiroshi

2015-10-01

Musical performance requires extremely fast and dexterous limb movements. The underlying biological mechanisms have been an object of interest among scientists and non-scientists for centuries. Numerous studies of musicians and non-musicians have demonstrated that neuroplastic adaptations through early and deliberate musical training endowed superior motor skill. However, little has been unveiled about what makes inter-individual differences in motor skills among musicians. Here we determined the attributes of inter-individual differences in the maximum rate of repetitive piano keystrokes in twenty-four pianists. Among various representative factors of neuromuscular functions, anatomical characteristics, and training history, a stepwise multiple regression analysis and generalized linear model identified two predominant predictors of the maximum rate of repetitive piano keystrokes; finger tapping rate and muscular strength of the elbow extensor. These results suggest a non-uniform role of individual limb muscles in the production of extremely fast repetitive multi-joint movements. Neither age of musical training initiation nor the amount of extensive musical training before age twenty was a predictor. Power grip strength was negatively related to the maximum rate of piano keystrokes only during the smallest tone production. These findings highlight the importance of innate biological nature and explicit training for motor virtuosity.

Suction is kid's play: extremely fast suction in newborn seahorses.

PubMed

Van Wassenbergh, Sam; Roos, Gert; Genbrugge, Annelies; Leysen, Heleen; Aerts, Peter; Adriaens, Dominique; Herrel, Anthony

2009-04-23

Ongoing anatomical development typically results in a gradual maturation of the feeding movements from larval to adult fishes. Adult seahorses are known to capture prey by rotating their long-snouted head extremely quickly towards prey, followed by powerful suction. This type of suction is powered by elastic recoil and requires very precise coordination of the movements of the associated feeding structures, making it an all-or-none phenomenon. Here, we show that newborn Hippocampus reidi are able to successfully feed using an extremely rapid and powerful snout rotation combined with a high-volume suction, surpassing that observed in adult seahorses. An inverse dynamic analysis shows that an elastic recoil mechanism is also used to power head rotation in newborn H. reidi. This illustrates how extreme levels of performance in highly complex musculoskeletal systems can be present at birth given a delayed birth and rapid development of functionally important structures. The fact that the head skeleton of newborn seahorses is still largely cartilaginous may not be problematic because the hydrodynamic stress on the rotating snout appeared considerably lower than in adult syngnathids.

Suction is kid's play: extremely fast suction in newborn seahorses

PubMed Central

Van Wassenbergh, Sam; Roos, Gert; Genbrugge, Annelies; Leysen, Heleen; Aerts, Peter; Adriaens, Dominique; Herrel, Anthony

2009-01-01

Ongoing anatomical development typically results in a gradual maturation of the feeding movements from larval to adult fishes. Adult seahorses are known to capture prey by rotating their long-snouted head extremely quickly towards prey, followed by powerful suction. This type of suction is powered by elastic recoil and requires very precise coordination of the movements of the associated feeding structures, making it an all-or-none phenomenon. Here, we show that newborn Hippocampus reidi are able to successfully feed using an extremely rapid and powerful snout rotation combined with a high-volume suction, surpassing that observed in adult seahorses. An inverse dynamic analysis shows that an elastic recoil mechanism is also used to power head rotation in newborn H. reidi. This illustrates how extreme levels of performance in highly complex musculoskeletal systems can be present at birth given a delayed birth and rapid development of functionally important structures. The fact that the head skeleton of newborn seahorses is still largely cartilaginous may not be problematic because the hydrodynamic stress on the rotating snout appeared considerably lower than in adult syngnathids. PMID:19324657

Earthquake detection through computationally efficient similarity search

PubMed Central

Yoon, Clara E.; O’Reilly, Ossian; Bergen, Karianne J.; Beroza, Gregory C.

2015-01-01

Seismology is experiencing rapid growth in the quantity of data, which has outpaced the development of processing algorithms. Earthquake detection—identification of seismic events in continuous data—is a fundamental operation for observational seismology. We developed an efficient method to detect earthquakes using waveform similarity that overcomes the disadvantages of existing detection methods. Our method, called Fingerprint And Similarity Thresholding (FAST), can analyze a week of continuous seismic waveform data in less than 2 hours, or 140 times faster than autocorrelation. FAST adapts a data mining algorithm, originally designed to identify similar audio clips within large databases; it first creates compact “fingerprints” of waveforms by extracting key discriminative features, then groups similar fingerprints together within a database to facilitate fast, scalable search for similar fingerprint pairs, and finally generates a list of earthquake detections. FAST detected most (21 of 24) cataloged earthquakes and 68 uncataloged earthquakes in 1 week of continuous data from a station located near the Calaveras Fault in central California, achieving detection performance comparable to that of autocorrelation, with some additional false detections. FAST is expected to realize its full potential when applied to extremely long duration data sets over a distributed network of seismic stations. The widespread application of FAST has the potential to aid in the discovery of unexpected seismic signals, improve seismic monitoring, and promote a greater understanding of a variety of earthquake processes. PMID:26665176

Environmental Information Management For Data Discovery and Access System

NASA Astrophysics Data System (ADS)

Giriprakash, P.

2011-01-01

Mercury is a federated metadata harvesting, search and retrieval tool based on both open source software and software developed at Oak Ridge National Laboratory. It was originally developed for NASA, and the Mercury development consortium now includes funding from NASA, USGS, and DOE. A major new version of Mercury was developed during 2007 and released in early 2008. This new version provides orders of magnitude improvements in search speed, support for additional metadata formats, integration with Google Maps for spatial queries, support for RSS delivery of search results, and ready customization to meet the needs of the multiple projects which use Mercury. For the end users, Mercury provides a single portal to very quickly search for data and information contained in disparate data management systems. It collects metadata and key data from contributing project servers distributed around the world and builds a centralized index. The Mercury search interfaces then allow ! the users to perform simple, fielded, spatial and temporal searches across these metadata sources. This centralized repository of metadata with distributed data sources provides extremely fast search results to the user, while allowing data providers to advertise the availability of their data and maintain complete control and ownership of that data.

Fast automated analysis of strong gravitational lenses with convolutional neural networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hezaveh, Yashar D.; Levasseur, Laurence Perreault; Marshall, Philip J.

Quantifying image distortions caused by strong gravitational lensing—the formation of multiple images of distant sources due to the deflection of their light by the gravity of intervening structures—and estimating the corresponding matter distribution of these structures (the ‘gravitational lens’) has primarily been performed using maximum likelihood modelling of observations. Our procedure is typically time- and resource-consuming, requiring sophisticated lensing codes, several data preparation steps, and finding the maximum likelihood model parameters in a computationally expensive process with downhill optimizers. Accurate analysis of a single gravitational lens can take up to a few weeks and requires expert knowledge of the physicalmore » processes and methods involved. Tens of thousands of new lenses are expected to be discovered with the upcoming generation of ground and space surveys. We report the use of deep convolutional neural networks to estimate lensing parameters in an extremely fast and automated way, circumventing the difficulties that are faced by maximum likelihood methods. We also show that the removal of lens light can be made fast and automated using independent component analysis of multi-filter imaging data. Our networks can recover the parameters of the ‘singular isothermal ellipsoid’ density profile, which is commonly used to model strong lensing systems, with an accuracy comparable to the uncertainties of sophisticated models but about ten million times faster: 100 systems in approximately one second on a single graphics processing unit. These networks can provide a way for non-experts to obtain estimates of lensing parameters for large samples of data.« less

Elasticity and Anelasticity of Materials from Time-Resolved X-ray Diffraction

NASA Astrophysics Data System (ADS)

Sinogeikin, S. V.; Smith, J.; Lin, C.; Bai, L.; Rod, E.; Shen, G.

2014-12-01

Recent advances in synchrotron sources, x-ray optics, area detectors, and sample environment control have enabled many time-resolved experimental techniques for studying materials at extreme pressure and temperature conditions. The High Pressure Collaborative Access Team (HPCAT) at the Advanced Photon Source has made a sustained effort to develop and assemble a powerful collection of high-pressure apparatus for time-resolved research, and considerable time has been invested in developing techniques for collecting high-quality time-resolved x-ray scattering data. In this talk we will outline recently developed capabilities at HPCAT for studying elasticity and anelasticity of minerals using fast compression and cyclic compression-decompression. A few recent studies will be highlighted. For example, with fast x-ray area detectors having millisecond time resolution, accurate thermal equations of state of materials at temperatures up to 1000K and megabar pressures can be collected in a matter of seconds using membrane-driven diamond anvil cells (DAC), yielding unprecedented time and pressure resolution of true isotherms. Short duration of the experiments eliminates temperature variation during the experiments and in general allows volume measurements at higher pressures and temperatures. Alternatively, high-frequency (kilohertz range) radial diffraction measurements in a panoramic DAC combined with fast, precise cyclic loading/unloading by piezo drive could provide the short time scale necessary for studying rheology of minerals from the elastic response and lattice relaxation as a function of pressure, temperature and strain rate. Finally, we consider some possible future applications for time-resolved high-pressure, high-temperature research of mantle minerals.

Fast automated analysis of strong gravitational lenses with convolutional neural networks

DOE PAGES

Hezaveh, Yashar D.; Levasseur, Laurence Perreault; Marshall, Philip J.

2017-08-30

Quantifying image distortions caused by strong gravitational lensing—the formation of multiple images of distant sources due to the deflection of their light by the gravity of intervening structures—and estimating the corresponding matter distribution of these structures (the ‘gravitational lens’) has primarily been performed using maximum likelihood modelling of observations. Our procedure is typically time- and resource-consuming, requiring sophisticated lensing codes, several data preparation steps, and finding the maximum likelihood model parameters in a computationally expensive process with downhill optimizers. Accurate analysis of a single gravitational lens can take up to a few weeks and requires expert knowledge of the physicalmore » processes and methods involved. Tens of thousands of new lenses are expected to be discovered with the upcoming generation of ground and space surveys. We report the use of deep convolutional neural networks to estimate lensing parameters in an extremely fast and automated way, circumventing the difficulties that are faced by maximum likelihood methods. We also show that the removal of lens light can be made fast and automated using independent component analysis of multi-filter imaging data. Our networks can recover the parameters of the ‘singular isothermal ellipsoid’ density profile, which is commonly used to model strong lensing systems, with an accuracy comparable to the uncertainties of sophisticated models but about ten million times faster: 100 systems in approximately one second on a single graphics processing unit. These networks can provide a way for non-experts to obtain estimates of lensing parameters for large samples of data.« less

Fast automated analysis of strong gravitational lenses with convolutional neural networks

NASA Astrophysics Data System (ADS)

Hezaveh, Yashar D.; Levasseur, Laurence Perreault; Marshall, Philip J.

2017-08-01

Quantifying image distortions caused by strong gravitational lensing—the formation of multiple images of distant sources due to the deflection of their light by the gravity of intervening structures—and estimating the corresponding matter distribution of these structures (the ‘gravitational lens’) has primarily been performed using maximum likelihood modelling of observations. This procedure is typically time- and resource-consuming, requiring sophisticated lensing codes, several data preparation steps, and finding the maximum likelihood model parameters in a computationally expensive process with downhill optimizers. Accurate analysis of a single gravitational lens can take up to a few weeks and requires expert knowledge of the physical processes and methods involved. Tens of thousands of new lenses are expected to be discovered with the upcoming generation of ground and space surveys. Here we report the use of deep convolutional neural networks to estimate lensing parameters in an extremely fast and automated way, circumventing the difficulties that are faced by maximum likelihood methods. We also show that the removal of lens light can be made fast and automated using independent component analysis of multi-filter imaging data. Our networks can recover the parameters of the ‘singular isothermal ellipsoid’ density profile, which is commonly used to model strong lensing systems, with an accuracy comparable to the uncertainties of sophisticated models but about ten million times faster: 100 systems in approximately one second on a single graphics processing unit. These networks can provide a way for non-experts to obtain estimates of lensing parameters for large samples of data.

Investigating the Wave Nature of the Outer Envelope of Halo Coronal Mass Ejections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwon, Ryun-Young; Vourlidas, Angelos, E-mail: rkwon@gmu.edu

We investigate the nature of the outer envelope of halo coronal mass ejections (H-CMEs) using multi-viewpoint observations from the Solar Terrestrial Relations Observatory-A , -B , and SOlar and Heliospheric Observatory coronagraphs. The 3D structure and kinematics of the halo envelopes and the driving CMEs are derived separately using a forward modeling method. We analyze three H-CMEs with peak speeds from 1355 to 2157 km s{sup −1}; sufficiently fast to drive shocks in the corona. We find that the angular widths of the halos range from 192° to 252°, while those of the flux ropes range between only 58° andmore » 91°, indicating that the halos are waves propagating away from the CMEs. The halo widths are in agreement with widths of Extreme Ultraviolet (EUV) waves in the low corona further demonstrating the common origin of these structures. To further investigate the wave nature of the halos, we model their 3D kinematic properties with a linear fast magnetosonic wave model. The model is able to reproduce the position of the halo flanks with realistic coronal medium assumptions but fails closer to the CME nose. The CME halo envelope seems to arise from a driven wave (or shock) close to the CME nose, but it is gradually becoming a freely propagating fast magnetosonic wave at the flanks. This interpretation provides a simple unifying picture for CME halos, EUV waves, and the large longitudinal spread of solar energetic particles.« less

On the calibration and use of Dual Electron Sensors for NASA's Magnetospheric MultiScale mission

NASA Astrophysics Data System (ADS)

Avanov, L. A.; Gliese, U.; Pollock, C. J.; Barrie, A.; Mariano, A. J.; Tucker, C. J.; Jacques, A. D.; Zeuch, M.; Shields, N.; Christian, K. D.

2013-12-01

The scientific target of NASA's Magnetospheric MultiScale (MMS) mission is to study the fundamentally important phenomenon of magnetic reconnection. Theoretical models of this process predict a small (order of ten kilometers) size for the diffusion region where electrons are demagnetized at the dayside magnetopause. Yet, the region may typically sweep over the spacecraft at relatively high speeds of 50km/s. That is why Fast Plasma Investigation (FPI) instrument suite must have extremely high time resolution for measurements of the 3D particle distribution functions. The Dual Electron Spectrometers (DESs) provide fast (30ms) 3D electron velocity distributions, from 10eV to 30,000 eV, as part of the Fast Plasma Investigation (FPI) on NASA's Magnetospheric MultiScale (MMS) mission. This is accomplished by combining the measurements from eight different spectrometers (packaged in four dual sets) on each MMS spacecraft to produce each full distribution. This approach presents a new and challenging aspect to the calibration and operation of these instruments. The response uniformity among the spectrometer set, the consistency and reliability of their calibration in both sensitivity and their phase space selectivity (energy and angle), and the approach to handling any temporal evolution of these calibrated characteristics all assume enhanced importance in this application. In this paper, we will present brief descriptions of the spectrometers and our approach their ground calibration, trended results of those calibrations, and our plans to detect, track, and respond to any temporal evolution in instrument performance through the life of the mission.

Experiment on a three-beam adaptive array for EHF frequency-hopped signals using a fast algorithm, phase-D

NASA Astrophysics Data System (ADS)

Yen, J. L.; Kremer, P.; Amin, N.; Fung, J.

1989-05-01

The Department of National Defence (Canada) has been conducting studies into multi-beam adaptive arrays for extremely high frequency (EHF) frequency hopped signals. A three-beam 43 GHz adaptive antenna and a beam control processor is under development. An interactive software package for the operation of the array, capable of applying different control algorithms is being written. A maximum signal to jammer plus noise ratio (SJNR) was found to provide superior performance in preventing degradation of user signals in the presence of nearby jammers. A new fast algorithm using a modified conjugate gradient approach was found to be a very efficient way to implement anti-jamming arrays based on maximum SJNR criterion. The present study was intended to refine and simplify this algorithm and to implement the algorithm on an experimental array for real-time evaluation of anti-jamming performance. A three-beam adaptive array was used. A simulation package was used in the evaluation of multi-beam systems using more than three beams and different user-jammer scenarios. An attempt to further reduce the computation burden through continued analysis of maximum SJNR met with limited success. A method to acquire and track an incoming laser beam is proposed.

Experiment on a three-beam adaptive array for EHF frequency-hopped signals using a fast algorithm, phase E

NASA Astrophysics Data System (ADS)

Yen, J. L.; Kremer, P.; Fung, J.

1990-05-01

The Department of National Defence (Canada) has been conducting studies into multi-beam adaptive arrays for extremely high frequency (EHF) frequency hopped signals. A three-beam 43 GHz adaptive antenna and a beam control processor is under development. An interactive software package for the operation of the array, capable of applying different control algorithms is being written. A maximum signal to jammer plus noise ratio (SJNR) has been found to provide superior performance in preventing degradation of user signals in the presence of nearby jammers. A new fast algorithm using a modified conjugate gradient approach has been found to be a very efficient way to implement anti-jamming arrays based on maximum SJNR criterion. The present study was intended to refine and simplify this algorithm and to implement the algorithm on an experimental array for real-time evaluation of anti-jamming performance. A three-beam adaptive array was used. A simulation package was used in the evaluation of multi-beam systems using more than three beams and different user-jammer scenarios. An attempt to further reduce the computation burden through further analysis of maximum SJNR met with limited success. The investigation of a new angle detector for spatial tracking in heterodyne laser space communications was completed.

SANSparallel: interactive homology search against Uniprot

PubMed Central

Somervuo, Panu; Holm, Liisa

2015-01-01

Proteins evolve by mutations and natural selection. The network of sequence similarities is a rich source for mining homologous relationships that inform on protein structure and function. There are many servers available to browse the network of homology relationships but one has to wait up to a minute for results. The SANSparallel webserver provides protein sequence database searches with immediate response and professional alignment visualization by third-party software. The output is a list, pairwise alignment or stacked alignment of sequence-similar proteins from Uniprot, UniRef90/50, Swissprot or Protein Data Bank. The stacked alignments are viewed in Jalview or as sequence logos. The database search uses the suffix array neighborhood search (SANS) method, which has been re-implemented as a client-server, improved and parallelized. The method is extremely fast and as sensitive as BLAST above 50% sequence identity. Benchmarks show that the method is highly competitive compared to previously published fast database search programs: UBLAST, DIAMOND, LAST, LAMBDA, RAPSEARCH2 and BLAT. The web server can be accessed interactively or programmatically at http://ekhidna2.biocenter.helsinki.fi/cgi-bin/sans/sans.cgi. It can be used to make protein functional annotation pipelines more efficient, and it is useful in interactive exploration of the detailed evidence supporting the annotation of particular proteins of interest. PMID:25855811

Experimental investigation of multi-scale non-equilibrium plasma dynamics

NASA Astrophysics Data System (ADS)

Bellan, Paul

2013-10-01

Lab experiments at Caltech resolve complex, detailed MHD dynamics spatially and temporally. Unbalanced forces drive fast plasma flows which tend to self-collimate via self-pinching. Collimation results from flow stagnation compressing embedded magnetic flux and so amplifying the magnetic field responsible for pinching. Measurements show that the collimated flow is essentially a dense plasma jet with embedded axial and azimuthal magnetic fields, i.e., a magnetic flux tube (flux rope). The measured jet velocity is in good agreement with an MHD acceleration model. Depending on how flux tube radius varies with axial position, jets flow into a flux tube from both ends or from just one end. Jets kink when the flux tube in which they are embedded breaches the Kruskal-Shafranov stability limit. The lateral acceleration of a sufficiently strong kink can produce an enormous effective gravity which provides the environment for an observed fine-scale, extremely fast Rayleigh-Taylor (RT) instability. The RT can erode the jet current channel to be smaller than the ion skin depth so there is a cascade from the ideal MHD scale of the kink to the non-MHD ion skin depth scale. This process can result in a magnetic reconnection whereby the jet and its embedded flux tube break. Supported by USDOE.

Observation of Reverse Saturable Absorption of an X-ray Laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, B. I.; Cho, M. S.; Kim, M.

A nonlinear absorber in which the excited state absorption is larger than the ground state can undergo a process called reverse saturable absorption. It is a well-known phenomenon in laser physics in the optical regime, but is more difficult to generate in the x-ray regime, where fast nonradiative core electron transitions typically dominate the population kinetics during light matter interactions. Here, we report the first observation of decreasing x-ray transmission in a solid target pumped by intense x-ray free electron laser pulses. The measurement has been made below the K-absorption edge of aluminum, and the x-ray intensity ranges are 10more » 16 –10 17 W=cm 2. It has been confirmed by collisional radiative population kinetic calculations, underscoring the fast spectral modulation of the x-ray pulses and charge states relevant to the absorption and transmission of x-ray photons. The processes shown through detailed simulations are consistent with reverse saturable absorption, which would be the first observation of this phenomena in the x-ray regime. These light matter interactions provide a unique opportunity to investigate optical transport properties in the extreme state of matters, as well as affording the potential to regulate ultrafast x-ray freeelectron laser pulses.« less

Observation of Reverse Saturable Absorption of an X-ray Laser

DOE PAGES

Cho, B. I.; Cho, M. S.; Kim, M.; ...

2017-08-16

A nonlinear absorber in which the excited state absorption is larger than the ground state can undergo a process called reverse saturable absorption. It is a well-known phenomenon in laser physics in the optical regime, but is more difficult to generate in the x-ray regime, where fast nonradiative core electron transitions typically dominate the population kinetics during light matter interactions. Here, we report the first observation of decreasing x-ray transmission in a solid target pumped by intense x-ray free electron laser pulses. The measurement has been made below the K-absorption edge of aluminum, and the x-ray intensity ranges are 10more » 16 –10 17 W=cm 2. It has been confirmed by collisional radiative population kinetic calculations, underscoring the fast spectral modulation of the x-ray pulses and charge states relevant to the absorption and transmission of x-ray photons. The processes shown through detailed simulations are consistent with reverse saturable absorption, which would be the first observation of this phenomena in the x-ray regime. These light matter interactions provide a unique opportunity to investigate optical transport properties in the extreme state of matters, as well as affording the potential to regulate ultrafast x-ray freeelectron laser pulses.« less

Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal

PubMed Central

Vermillion, Katie L.; Anderson, Kyle J.; Hampton, Marshall

2015-01-01

Throughout the hibernation season, the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) experiences extreme fluctuations in heart rate, metabolism, oxygen consumption, and body temperature, along with prolonged fasting and immobility. These conditions necessitate different functional requirements for the heart, which maintains contractile function throughout hibernation, and the skeletal muscle, which remains largely inactive. The adaptations used to maintain these contractile organs under such variable conditions serves as a natural model to study a variety of medically relevant conditions including heart failure and disuse atrophy. To better understand how two different muscle tissues maintain function throughout the extreme fluctuations of hibernation we performed Illumina HiSeq 2000 sequencing of cDNAs to compare the transcriptome of heart and skeletal muscle across the circannual cycle. This analysis resulted in the identification of 1,076 and 1,466 differentially expressed genes in heart and skeletal muscle, respectively. In both heart and skeletal muscle we identified a distinct cold-tolerant mechanism utilizing peroxisomal metabolism to make use of elevated levels of unsaturated depot fats. The skeletal muscle transcriptome also shows an early increase in oxidative capacity necessary for the altered fuel utilization and increased oxygen demand of shivering. Expression of the fetal gene expression profile is used to maintain cardiac tissue, either through increasing myocyte size or proliferation of resident cardiomyocytes, while skeletal muscle function and mass are protected through transcriptional regulation of pathways involved in protein turnover. This study provides insight into how two functionally distinct muscles maintain function under the extreme conditions of mammalian hibernation. PMID:25572546

SoFAST: Automated Flare Detection with the PROBA2/SWAP EUV Imager

NASA Astrophysics Data System (ADS)

Bonte, K.; Berghmans, D.; De Groof, A.; Steed, K.; Poedts, S.

2013-08-01

The Sun Watcher with Active Pixels and Image Processing (SWAP) EUV imager onboard PROBA2 provides a non-stop stream of coronal extreme-ultraviolet (EUV) images at a cadence of typically 130 seconds. These images show the solar drivers of space-weather, such as flares and erupting filaments. We have developed a software tool that automatically processes the images and localises and identifies flares. On one hand, the output of this software tool is intended as a service to the Space Weather Segment of ESA's Space Situational Awareness (SSA) program. On the other hand, we consider the PROBA2/SWAP images as a model for the data from the Extreme Ultraviolet Imager (EUI) instrument prepared for the future Solar Orbiter mission, where onboard intelligence is required for prioritising data within the challenging telemetry quota. In this article we present the concept of the software, the first statistics on its effectiveness and the online display in real time of its results. Our results indicate that it is not only possible to detect EUV flares automatically in an acquired dataset, but that quantifying a range of EUV dynamics is also possible. The method is based on thresholding of macropixelled image sequences. The robustness and simplicity of the algorithm is a clear advantage for future onboard use.

Extreme ultraviolet emission and confinement of tin plasmas in the presence of a magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roy, Amitava, E-mail: roy@fzu.cz, E-mail: aroy@barc.gov.in; HiLASE Project, Department of Diode-pumped Lasers, Institute of Physics of the ASCR, Na Slovance 2, 18221 Prague; Murtaza Hassan, Syed

2014-05-15

We investigated the role of a guiding magnetic field on extreme ultraviolet (EUV) and ion emission from a laser produced Sn plasma for various laser pulse duration and intensity. For producing plasmas, planar slabs of pure Sn were irradiated with 1064 nm, Nd:YAG laser pulses with varying pulse duration (5–15 ns) and intensity. A magnetic trap was fabricated with the use of two neodymium permanent magnets which provided a magnetic field strength ∼0.5 T along the plume expansion direction. Our results indicate that the EUV conversion efficiency do not depend significantly on applied axial magnetic field. Faraday Cup ion analysis of Sn plasmamore » show that the ion flux reduces by a factor of ∼5 with the application of an axial magnetic field. It was found that the plasma plume expand in the lateral direction with peak velocity measured to be ∼1.2 cm/μs and reduced to ∼0.75 cm/μs with the application of an axial magnetic field. The plume expansion features recorded using fast photography in the presence and absence of 0.5 T axial magnetic field are simulated using particle-in-cell code. Our simulation results qualitatively predict the plasma behavior.« less

Irradiation dose detection of irradiated milk powder using visible and near-infrared spectroscopy and chemometrics.

PubMed

Kong, W W; Zhang, C; Liu, F; Gong, A P; He, Y

2013-08-01

The objective of this study was to examine the possibility of applying visible and near-infrared spectroscopy to the quantitative detection of irradiation dose of irradiated milk powder. A total of 150 samples were used: 100 for the calibration set and 50 for the validation set. The samples were irradiated at 5 different dose levels in the dose range 0 to 6.0 kGy. Six different pretreatment methods were compared. The prediction results of full spectra given by linear and nonlinear calibration methods suggested that Savitzky-Golay smoothing and first derivative were suitable pretreatment methods in this study. Regression coefficient analysis was applied to select effective wavelengths (EW). Less than 10 EW were selected and they were useful for portable detection instrument or sensor development. Partial least squares, extreme learning machine, and least squares support vector machine were used. The best prediction performance was achieved by the EW-extreme learning machine model with first-derivative spectra, and correlation coefficients=0.97 and root mean square error of prediction=0.844. This study provided a new approach for the fast detection of irradiation dose of milk powder. The results could be helpful for quality detection and safety monitoring of milk powder. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Short-term fasts increase levels of halogenated flame retardants in tissues of a wild incubating bird.

PubMed

Marteinson, Sarah C; Drouillard, Ken G; Verreault, Jonathan

2016-04-01

Many species are adapted for fasting during parts of their life cycle. For species undergoing extreme fasts, lipid stores are mobilized and accumulated contaminants can be released to exert toxicological effects. However, it is unknown if short-term fasting events may have a similar effect. The objective of this study was to determine if short successive fasts are related to contaminant levels in liver and plasma of birds. In ring-billed gulls (Larus delawarensis), both members of the pair alternate between incubating the nest for several hours (during which they fast) and foraging, making them a useful model for examining this question. Birds were equipped with miniature data loggers recording time and GPS position for two days to determine the proportion and duration of time birds spent in these two activities. Liver and plasma samples were collected, and halogenated flame retardants (HFRs) (PBDEs and dechlorane plus) and organochlorines (OCs) (PCBs, DDTs, and chlordane-related compounds) were determined. Most birds (79%) exhibited plasma lipid content below 1%, indicating a likely fasted state, and plasma lipid percent declined with the number of hours spent at the nest site. The more time birds spent at their nest site, the higher were their plasma and liver concentrations of HFRs. However, body condition indices were unrelated to either the amount of time birds fasted at the nest site or contaminant levels, suggesting that lipid mobilization might not have been severe enough to affect overall body condition of birds and to explain the relationship between fasting and HFR concentrations. A similar relationship between fasting and OC levels was not observed, suggesting that different factors are affecting short-term temporal variations in concentrations of these two classes of contaminants. This study demonstrates that short fasts can be related to increased internal contaminant exposure in birds and that this may be a confounding factor in research and monitoring involving tissue concentrations of HFRs in wild birds. Copyright © 2015 Elsevier Inc. All rights reserved.

An Extreme-ultraviolet Wave Generating Upward Secondary Waves in a Streamer-like Solar Structure

NASA Astrophysics Data System (ADS)

Zheng, Ruisheng; Chen, Yao; Feng, Shiwei; Wang, Bing; Song, Hongqiang

2018-05-01

Extreme-ultraviolet (EUV) waves, spectacular horizontally propagating disturbances in the low solar corona, always trigger horizontal secondary waves (SWs) when they encounter the ambient coronal structure. We present the first example of upward SWs in a streamer-like structure after the passing of an EUV wave. This event occurred on 2017 June 1. The EUV wave happened during a typical solar eruption including a filament eruption, a coronal mass ejection (CME), and a C6.6 flare. The EUV wave was associated with quasi-periodic fast propagating (QFP) wave trains and a type II radio burst that represented the existence of a coronal shock. The EUV wave had a fast initial velocity of ∼1000 km s‑1, comparable to high speeds of the shock and the QFP wave trains. Intriguingly, upward SWs rose slowly (∼80 km s‑1) in the streamer-like structure after the sweeping of the EUV wave. The upward SWs seemed to originate from limb brightenings that were caused by the EUV wave. All of the results show that the EUV wave is a fast-mode magnetohydrodynamic (MHD) shock wave, likely triggered by the flare impulses. We suggest that part of the EUV wave was probably trapped in the closed magnetic fields of the streamer-like structure, and upward SWs possibly resulted from the release of slow-mode trapped waves. It is believed that the interplay of the strong compression of the coronal shock and the configuration of the streamer-like structure is crucial for the formation of upward SWs.

STEREO OBSERVATIONS OF FAST MAGNETOSONIC WAVES IN THE EXTENDED SOLAR CORONA ASSOCIATED WITH EIT/EUV WAVES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwon, Ryun-Young; Ofman, Leon; Kramar, Maxim

2013-03-20

We report white-light observations of a fast magnetosonic wave associated with a coronal mass ejection observed by STEREO/SECCHI/COR1 inner coronagraphs on 2011 August 4. The wave front is observed in the form of density compression passing through various coronal regions such as quiet/active corona, coronal holes, and streamers. Together with measured electron densities determined with STEREO COR1 and Extreme UltraViolet Imager (EUVI) data, we use our kinematic measurements of the wave front to calculate coronal magnetic fields and find that the measured speeds are consistent with characteristic fast magnetosonic speeds in the corona. In addition, the wave front turns outmore » to be the upper coronal counterpart of the EIT wave observed by STEREO EUVI traveling against the solar coronal disk; moreover, stationary fronts of the EIT wave are found to be located at the footpoints of deflected streamers and boundaries of coronal holes, after the wave front in the upper solar corona passes through open magnetic field lines in the streamers. Our findings suggest that the observed EIT wave should be in fact a fast magnetosonic shock/wave traveling in the inhomogeneous solar corona, as part of the fast magnetosonic wave propagating in the extended solar corona.« less

Fast-sausage oscillations in coronal loops with smooth boundary

NASA Astrophysics Data System (ADS)

Lopin, I.; Nagorny, I.

2014-12-01

Aims: The effect of the transition layer (shell) in nonuniform coronal loops with a continuous radial density profile on the properties of fast-sausage modes are studied analytically and numerically. Methods: We modeled the coronal waveguide as a structured tube consisting of a cord and a transition region (shell) embedded within a magnetic uniform environment. The derived general dispersion relation was investigated analytically and numerically in the context of frequency, cut-off wave number, and the damping rate of fast-sausage oscillations for various values of loop parameters. Results: The frequency of the global fast-sausage mode in the loops with a diffuse (or smooth) boundary is determined mainly by the external Alfvén speed and longitudinal wave number. The damping rate of such a mode can be relatively low. The model of coronal loop with diffuse boundary can support a comparatively low-frequency, global fast-sausage mode of detectable quality without involving extremely low values of the density contrast. The effect of thin transition layer (corresponds to the loops with steep boundary) is negligible and produces small reductions of oscillation frequency and relative damping rate in comparison with the case of step-function density profile. Seismological application of obtained results gives the estimated Alfvén speed outside the flaring loop about 3.25 Mm/s.

Interplanetary Propagation Behavior of the Fast Coronal Mass Ejection on 23 July 2012

NASA Astrophysics Data System (ADS)

Temmer, M.; Nitta, N. V.

2015-03-01

The fast coronal mass ejection (CME) on 23 July 2012 caused attention because of its extremely short transit time from the Sun to 1 AU, which was shorter than 21 h. In situ data from STEREO-A revealed the arrival of a fast forward shock with a speed of more than 2200 km s-1 followed by a magnetic structure moving with almost 1900 km s-1. We investigate the propagation behavior of the CME shock and magnetic structure with the aim to reproduce the short transit time and high impact speed as derived from in situ data. We carefully measured the 3D kinematics of the CME using the graduated cylindrical shell model and obtained a maximum speed of 2580±280 km s-1 for the CME shock and 2270±420 km s-1 for its magnetic structure. Based on the 3D kinematics, the drag-based model (DBM) reproduces the observational data reasonably well. To successfully simulate the CME shock, the ambient flow speed needs to have an average value close to the slow solar wind speed (450 km s-1), and the initial shock speed at a distance of 30 R ⊙ should not exceed ≈ 2300 km s-1, otherwise it would arrive much too early at STEREO-A. The model results indicate that an extremely small aerodynamic drag force is exerted on the shock, smaller by one order of magnitude than average. As a consequence, the CME hardly decelerates in interplanetary space and maintains its high initial speed. The low aerodynamic drag can only be reproduced when the density of the ambient solar wind flow, in which the fast CME propagates, is decreased to ρ sw=1 - 2 cm-3 at the distance of 1 AU. This result is consistent with the preconditioning of interplanetary space by a previous CME.

Reducing robotic guidance during robot-assisted gait training improves gait function: a case report on a stroke survivor.

PubMed

Krishnan, Chandramouli; Kotsapouikis, Despina; Dhaher, Yasin Y; Rymer, William Z

2013-06-01

To test the feasibility of patient-cooperative robotic gait training for improving locomotor function of a chronic stroke survivor with severe lower-extremity motor impairments. Single-subject crossover design. Performed in a controlled laboratory setting. A 62-year-old man with right temporal lobe ischemic stroke was recruited for this study. The baseline lower-extremity Fugl-Meyer score of the subject was 10 on a scale of 34, which represented severe impairment in the paretic leg. However, the subject had a good ambulation level (community walker with the aid of a stick cane and ankle-foot orthosis) and showed no signs of sensory or cognitive impairments. The subject underwent 12 sessions (3 times per week for 4wk) of conventional robotic training with the Lokomat, where the robot provided full assistance to leg movements while walking, followed by 12 sessions (3 times per week for 4wk) of patient-cooperative robotic control training, where the robot provided minimal guidance to leg movements during walking. Clinical outcomes were evaluated before the start of the intervention, immediately after 4 weeks of conventional robotic training, and immediately after 4 weeks of cooperative control robotic training. These included: (1) self-selected and fast walking speed, (2) 6-minute walk test, (3) Timed Up & Go test, and (4) lower-extremity Fugl-Meyer score. Results showed that clinical outcomes changed minimally after full guidance robotic training, but improved considerably after 4 weeks of reduced guidance robotic training. The findings from this case study suggest that cooperative control robotic training is superior to conventional robotic training and is a feasible option to restoring locomotor function in ambulatory stroke survivors with severe motor impairments. A larger trial is needed to verify the efficacy of this advanced robotic control strategy in facilitating gait recovery after stroke. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Single-step ethanol production from lignocellulose using novel extremely thermophilic bacteria.

PubMed

Svetlitchnyi, Vitali A; Kensch, Oliver; Falkenhan, Doris A; Korseska, Svenja G; Lippert, Nadine; Prinz, Melanie; Sassi, Jamaleddine; Schickor, Anke; Curvers, Simon

2013-02-28

Consolidated bioprocessing (CBP) of lignocellulosic biomass to ethanol using thermophilic bacteria provides a promising solution for efficient lignocellulose conversion without the need for additional cellulolytic enzymes. Most studies on the thermophilic CBP concentrate on co-cultivation of the thermophilic cellulolytic bacterium Clostridium thermocellum with non-cellulolytic thermophilic anaerobes at temperatures of 55°C-60°C. We have specifically screened for cellulolytic bacteria growing at temperatures >70°C to enable direct conversion of lignocellulosic materials into ethanol. Seven new strains of extremely thermophilic anaerobic cellulolytic bacteria of the genus Caldicellulosiruptor and eight new strains of extremely thermophilic xylanolytic/saccharolytic bacteria of the genus Thermoanaerobacter isolated from environmental samples exhibited fast growth at 72°C, extensive lignocellulose degradation and high yield ethanol production on cellulose and pretreated lignocellulosic biomass. Monocultures of Caldicellulosiruptor strains degraded up to 89-97% of the cellulose and hemicellulose polymers in pretreated biomass and produced up to 72 mM ethanol on cellulose without addition of exogenous enzymes. In dual co-cultures of Caldicellulosiruptor strains with Thermoanaerobacter strains the ethanol concentrations rose 2- to 8.2-fold compared to cellulolytic monocultures. A co-culture of Caldicellulosiruptor DIB 087C and Thermoanaerobacter DIB 097X was particularly effective in the conversion of cellulose to ethanol, ethanol comprising 34.8 mol% of the total organic products. In contrast, a co-culture of Caldicellulosiruptor saccharolyticus DSM 8903 and Thermoanaerobacter mathranii subsp. mathranii DSM 11426 produced only low amounts of ethanol. The newly discovered Caldicellulosiruptor sp. strain DIB 004C was capable of producing unexpectedly large amounts of ethanol from lignocellulose in fermentors. The established co-cultures of new Caldicellulosiruptor strains with new Thermoanaerobacter strains underline the importance of using specific strain combinations for high ethanol yields. These co-cultures provide an efficient CBP pathway for ethanol production and represent an ideal starting point for development of a highly integrated commercial ethanol production process.

Comparison of Reconstruction and Control algorithms on the ESO end-to-end simulator OCTOPUS

NASA Astrophysics Data System (ADS)

Montilla, I.; Béchet, C.; Lelouarn, M.; Correia, C.; Tallon, M.; Reyes, M.; Thiébaut, É.

Extremely Large Telescopes are very challenging concerning their Adaptive Optics requirements. Their diameters, the specifications demanded by the science for which they are being designed for, and the planned use of Extreme Adaptive Optics systems, imply a huge increment in the number of degrees of freedom in the deformable mirrors. It is necessary to study new reconstruction algorithms to implement the real time control in Adaptive Optics at the required speed. We have studied the performance, applied to the case of the European ELT, of three different algorithms: the matrix-vector multiplication (MVM) algorithm, considered as a reference; the Fractal Iterative Method (FrIM); and the Fourier Transform Reconstructor (FTR). The algorithms have been tested on ESO's OCTOPUS software, which simulates the atmosphere, the deformable mirror, the sensor and the closed-loop control. The MVM is the default reconstruction and control method implemented in OCTOPUS, but it scales in O(N2) operations per loop so it is not considered as a fast algorithm for wave-front reconstruction and control on an Extremely Large Telescope. The two other methods are the fast algorithms studied in the E-ELT Design Study. The performance, as well as their response in the presence of noise and with various atmospheric conditions, has been compared using a Single Conjugate Adaptive Optics configuration for a 42 m diameter ELT, with a total amount of 5402 actuators. Those comparisons made on a common simulator allow to enhance the pros and cons of the various methods, and give us a better understanding of the type of reconstruction algorithm that an ELT demands.

Vascular anomalies and the growth of limbs: a review.

PubMed

Enjolras, Odile; Chapot, René; Merland, Jean Jacques

2004-11-01

Growth of the limb in a child can be impaired, with the coexistence of a vascular malformation. In these vascular bone syndromes, altered growth is manifest as overgrowth or hypotrophy. The vascular malformation is usually complex and gets progressively worse with time. The two types of vascular anomalies in limbs, fast-flow and slow-flow, can be associated with limb length discrepancies. The fast-flow vascular malformations together with arteriovenous fistulae are part of Parkes Weber syndrome, characterized by congenital red cutaneous staining, hypertrophy in girth and increasing of limb length, lymphedema, increasing skin alterations due to a distal vascular steal, and pain, all of which develop during childhood. Treatment is generally conservative. An affected lower extremity can be complicated by pelvic tilting and scoliosis because leg length discrepancy may reach 10 cm. To avoid such a course, stapling epiphysiodesis of the knee cartilages is often performed, but this orthopedic procedure may augment the worsening of the arterial venous malformation in the limb. Therefore, less aggressive orthopedic management is preferable. Slow-flow vascular anomalies associated with limb growth alteration include (1) a diffuse capillary malformation (port-wine stain) with congenital hypertrophy of the involved extremity which is non-progressive; (2) purely venous malformations invading skin, muscles and joints, with pain, functional impairment, a chronic localized intravascular coagulopathy requiring distinctive management, and usually a slight undergrowth of the affected extremity and progressing amyotrophy; (3) the triad of a port-wine stain, anomalous veins and overgrowth of the limb, often known as Klippel-Trenaunay syndrome, which requires orthopedic management to decide the optimal timing for epiphysiodesis (i.e. when leg length discrepancy is >2.5 cm). Varicose veins are sometimes surgically removed after ultrasonographic and Doppler evaluation has confirmed a normal deep venous system. Capillary malformations can be effectively treated with pulsed dye laser, but results are usually poor in distal extremities.

Primary Care Providers' Knowledge and Practices of Diabetes Management During Ramadan.

PubMed

Ali, Mujtaba; Adams, Alexandra; Hossain, Md Anwar; Sutin, David; Han, Benjamin Hyun

2016-01-01

There are an estimated 3.5 million Muslims in North America. During the holy month of Ramadan, healthy adult Muslims are to fast from predawn to after sunset. While there are exemptions for older and sick adults, many adults with diabetes fast during Ramadan. However, there are risks associated with fasting and specific management considerations for patients with diabetes. We evaluated provider practices and knowledge regarding the management of patients with diabetes who fast during Ramadan. A 15-question quality improvement survey based on a literature review and the American Diabetes Association guidelines was developed and offered to providers at the outpatient primary care and geriatric clinics at an inner-city hospital in New York City. Forty-five providers completed the survey. Most respondents did not ask their Muslim patients with diabetes if they were fasting during the previous Ramadan. Knowledge of fasting practices during Ramadan was variable, and most felt uncomfortable managing patients with diabetes during Ramadan. There is room for improvement in educating providers about specific cultural and medical issues regarding fasting for patients with diabetes during Ramadan. © The Author(s) 2015.

Multiple-Barrier Resonant Tunneling Structures for Application in a Microwave Generator Stabilized by Microstrip Resonator

DTIC Science & Technology

2000-06-23

conductivity ( NDC ) effects in double barrier resonant tunneling structures (DBRTS) prove the extremely fast frequency response of charge transport (less...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP013131 TITLE: Multiple-Barrier Resonant Tunneling Structures for...Institute Multiple-barrier resonant tunneling structures for application in a microwave generator stabilized by microstrip resonator S. V. Evstigneev, A. L

Extremely fast and highly selective detection of nitroaromatic explosive vapours using fluorescent polymer thin films.

PubMed

Demirel, Gokcen Birlik; Daglar, Bihter; Bayindir, Mehmet

2013-07-14

A novel sensing material based on pyrene doped polyethersulfone worm-like structured thin film is developed using a facile technique for detection of nitroaromatic explosive vapours. The formation of π-π stacking in the thin fluorescent film allows a highly sensitive fluorescence quenching which is detectable by the naked eye in a response time of a few seconds.

Cultivating the Social, Emotional, and Inner Lives of Children and Teachers

ERIC Educational Resources Information Center

Lantieri, Linda

2012-01-01

Adults often feel the pressures of today's fast-paced world and think back longingly to a time when their daily lives were a lot less hectic. One third of the respondents in one study report that they are living with "extreme stress" and almost half feel that the level of stress in their lives has increased over the past five years. Children are…

Monte Carlo Simulation of Soil Moisture Effects on Anti-Tank Landmines Detection by Neutron Backscattering Technique

NASA Astrophysics Data System (ADS)

Mowlawi, Ali Asghar; Yazdani, Majed

The detection of landmines using available technologies is a time consuming, expensive, and extremely dangerous job, so that there is a need for technological breakthroughs in this field. One of the safest and most effective technologies to landmine and explosive detection is the neutron backscattering technique. The slowing-down of fast neutrons to the thermal energy is a direct measure of the concentration of hydrogen, one of the main elements present in explosive materials. The elastic scattering of fast neutrons is affected by the strong resonances in the cross-section of the three other elements of explosives: nitrogen, oxygen, and carbon. In this work, Monte Carlo estimations of the soil moisture effects on landmine detection are presented.

Electric-field effects in the twist-bend nematic phase

NASA Astrophysics Data System (ADS)

Meyer, Claire; Dozov, Ivan; Davidson, Patrick; Luckhurst, Geoffrey R.; Dokli, Irena; Knezevic, Anamarija; Lesac, Andreja

2018-02-01

In the recently discovered Twist-Bend Nematic (NTB) phase, the nematic director is spontaneously distorted and twisted along a conical helix with an extremely short pitch, 10 nm. We have investigated the behavior of the NTB phase subject to an electric-field. We show that, due to the periodic NTB structure, the electro-optic effects are not nematic-like but are close analogs to those in the smectic and cholesteric phases. In particular, we have studied the fast (sub-microsecond) flexoelectrically-induced rotation of the optic axis, which is similar to the electroclinic effect in the SmA* phase and the flexoelectric response of short-pitch cholesterics. We discuss the possible applications of the fast NTB electro-optic effects.

Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels

PubMed Central

Hindle, Allyson G.; Grabek, Katharine R.; Epperson, L. Elaine; Karimpour-Fard, Anis

2014-01-01

Small-bodied hibernators partition the year between active homeothermy and hibernating heterothermy accompanied by fasting. To define molecular events underlying hibernation that are both dependent and independent of fasting, we analyzed the liver proteome among two active and four hibernation states in 13-lined ground squirrels. We also examined fall animals transitioning between fed homeothermy and fasting heterothermy. Significantly enriched pathways differing between activity and hibernation were biased toward metabolic enzymes, concordant with the fuel shifts accompanying fasting physiology. Although metabolic reprogramming to support fasting dominated these data, arousing (rewarming) animals had the most distinct proteome among the hibernation states. Instead of a dominant metabolic enzyme signature, torpor-arousal cycles featured differences in plasma proteins and intracellular membrane traffic and its regulation. Phosphorylated NSFL1C, a membrane regulator, exhibited this torpor-arousal cycle pattern; its role in autophagosome formation may promote utilization of local substrates upon metabolic reactivation in arousal. Fall animals transitioning to hibernation lagged in their proteomic adjustment, indicating that the liver is more responsive than preparatory to the metabolic reprogramming of hibernation. Specifically, torpor use had little impact on the fall liver proteome, consistent with a dominant role of nutritional status. In contrast to our prediction of reprogramming the transition between activity and hibernation by gene expression and then within-hibernation transitions by posttranslational modification (PTM), we found extremely limited evidence of reversible PTMs within torpor-arousal cycles. Rather, acetylation contributed to seasonal differences, being highest in winter (specifically in torpor), consistent with fasting physiology and decreased abundance of the mitochondrial deacetylase, SIRT3. PMID:24642758

Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups

PubMed Central

Soñanez-Organis, José G.; Viscarra, Jose A.; Jaques, John T.; MacKenzie, Duncan S.; Crocker, Daniel E.; Ortiz, Rudy M.

2016-01-01

Prolonged food deprivation in mammals typically reduces glucose, insulin, and thyroid hormone (TH) concentrations, as well as tissue deiodinase (DI) content and activity, which, collectively, suppress metabolism. However, in elephant seal pups, prolonged fasting does not suppress TH levels; it is associated with upregulation of adipose TH-mediated cellular mechanisms and adipose-specific insulin resistance. The functional relevance of this apparent paradox and the effects of glucose and insulin on TH-mediated signaling in an insulin-resistant tissue are not well defined. To address our hypothesis that insulin increases adipose TH signaling in pups during extended fasting, we assessed the changes in TH-associated genes in response to an insulin infusion in early- and late-fasted pups. In late fasting, insulin increased DI1, DI2, and THrβ-1 mRNA expression by 566%, 44%, and 267% at 60 min postinfusion, respectively, with levels decreasing by 120 min. Additionally, we performed a glucose challenge in late-fasted pups to differentiate between insulin- and glucose-mediated effects on TH signaling. In contrast to the insulin-induced effects, glucose infusion did not increase the expressions of DI1, DI2, and THrβ-1 until 120 min, suggesting that glucose delays the onset of the insulin-induced effects. The data also suggest that fasting duration increases the sensitivity of adipose TH-mediated mechanisms to insulin, some of which may be mediated by increased glucose. These responses appear to be unique among mammals and to have evolved in elephant seals to facilitate their adaptation to tolerate an extreme physiological condition. PMID:26739649

A geostatistical extreme-value framework for fast simulation of natural hazard events

PubMed Central

Stephenson, David B.

2016-01-01

We develop a statistical framework for simulating natural hazard events that combines extreme value theory and geostatistics. Robust generalized additive model forms represent generalized Pareto marginal distribution parameters while a Student’s t-process captures spatial dependence and gives a continuous-space framework for natural hazard event simulations. Efficiency of the simulation method allows many years of data (typically over 10 000) to be obtained at relatively little computational cost. This makes the model viable for forming the hazard module of a catastrophe model. We illustrate the framework by simulating maximum wind gusts for European windstorms, which are found to have realistic marginal and spatial properties, and validate well against wind gust measurements. PMID:27279768

XVIS: Visualization for the Extreme-Scale Scientific-Computation Ecosystem Final Scientific/Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geveci, Berk; Maynard, Robert

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. The XVis project brought together collaborators from predominant DOE projects for visualization on accelerators and combining their respectivemore » features into a new visualization toolkit called VTK-m.« less

Following the dynamics of matter with femtosecond precision using the X-ray streaking method

DOE PAGES

David, C.; Karvinen, P.; Sikorski, M.; ...

2015-01-06

X-ray Free Electron Lasers (FELs) can produce extremely intense and very short pulses, down to below 10 femtoseconds (fs). Among the key applications are ultrafast time-resolved studies of dynamics of matter by observing responses to fast excitation pulses in a pump-probe manner. Detectors with sufficient time resolution for observing these processes are not available. Therefore, such experiments typically measure a sample's full dynamics by repeating multiple pump-probe cycles at different delay times. This conventional method assumes that the sample returns to an identical or very similar state after each cycle. Here we describe a novel approach that can provide amore » time trace of responses following a single excitation pulse, jitter-free, with fs timing precision. We demonstrate, in an X-ray diffraction experiment, how it can be applied to the investigation of ultrafast irreversible processes.« less

A fast microchannel plate-scintillator detector for velocity map imaging and imaging mass spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winter, B.; King, S. J.; Vallance, C., E-mail: claire.vallance@chem.ox.ac.uk

2014-02-15

The time resolution achievable using standard position-sensitive ion detectors, consisting of a chevron pair of microchannel plates coupled to a phosphor screen, is primarily limited by the emission lifetime of the phosphor, around 70 ns for the most commonly used P47 phosphor. We demonstrate that poly-para-phenylene laser dyes may be employed extremely effectively as scintillators, exhibiting higher brightness and much shorter decay lifetimes than P47. We provide an extensive characterisation of the properties of such scintillators, with a particular emphasis on applications in velocity-map imaging and microscope-mode imaging mass spectrometry. The most promising of the new scintillators exhibits an electron-to-photonmore » conversion efficiency double that of P47, with an emission lifetime an order of magnitude shorter. The new scintillator screens are vacuum stable and show no signs of signal degradation even over longer periods of operation.« less

Interactive planning of cryotherapy using physics-based simulation.

PubMed

Talbot, Hugo; Lekkal, Myriam; Bessard-Duparc, Remi; Cotin, Stephane

2014-01-01

Cryotherapy is a rapidly growing minimally invasive technique for the treatment of certain tumors. It consists in destroying cancer cells by extreme cold delivered at the tip of a needle-like probe. As the resulting iceball is often smaller than the targeted tumor, a key to the success of cryotherapy is the planning of the position and orientation of the multiple probes required to treat a tumor, while avoiding any damage to the surrounding tissues. In order to provide such a planning tool, a number of challenges need to be addressed such as fast and accurate computation of the freezing process or interactive positioning of the virtual cryoprobes in the pre-operative image volume. To address these challenges, we present an approach which relies on an advanced computational framework, and a gesture-based planning system using contact-less technology to remain compatible with a use in a sterile environment.

Mechanism of plasma-assisted ignition for H2 and C1-C5 hydrocarbons

NASA Astrophysics Data System (ADS)

Starikovskiy, Andrey; Aleksandrov, Nikolay

2016-09-01

Nonequilibrium plasma demonstrates ability to control ultra-lean, ultra-fast, low-temperature flames and appears to be an extremely promising technology for a wide range of applications, including aviation GTEs, piston engines, ramjets, scramjets and detonation initiation for pulsed detonation engines. To use nonequilibrium plasma for ignition and combustion in real energetic systems, one must understand the mechanisms of plasma-assisted ignition and combustion and be able to numerically simulate the discharge and combustion processes under various conditions. A new, validated mechanism for high-temperature hydrocarbon plasma assisted combustion was built and allows to qualitatively describe plasma-assisted combustion close and above the self-ignition threshold. The principal mechanisms of plasma-assisted ignition and combustion have been established and validated for a wide range of plasma and gas parameters. These results provide a basis for improving various energy-conversion combustion systems, from automobile to aircraft engines, using nonequilibrium plasma methods.

Infrasonic Influence of Volcanos

NASA Astrophysics Data System (ADS)

Hosman, Ashley

2014-03-01

My presentation will consist of a poster on the use of ring laser interferometers to detect infrasound. The research was performed during the summer of 2013 and it focused on the finding infrasound emissions created by volcanic activity. I will explain how a ring laser works and discuss how I analyze the collected data using Fast Fourier Transforms. Due to the extreme distances over which infrasound can travel, I will also stress the need to compare the detected responses to specific volcanic eruptions. Finally, I will purpose practical applications of my research. One of the more promising applications is to use ring lasers to detect volcanic activity in remote areas such as parts of the Aleutian Islands. There is considerable air traffic over the Aleutian Islands. Volcanic plumes are a significant aviation hazard and can damage jet engines to the extent that they will no longer operate. Thank you to the NSF ans NASA foundations for providing funding for this reseach.

Invited Article: Narrowband terahertz bandpass filters employing stacked bilayer metasurface antireflection structures

NASA Astrophysics Data System (ADS)

Chang, Chun-Chieh; Huang, Li; Nogan, John; Chen, Hou-Tong

2018-05-01

We experimentally demonstrate high-performance narrowband terahertz (THz) bandpass filters through cascading multiple bilayer metasurface antireflection structures. Each bilayer metasurface, consisting of a square array of silicon pillars with a self-aligned top gold resonator-array and a complementary bottom gold slot-array, enables near-zero reflection and simultaneously close-to-unity single-band transmission at designed operational frequencies in the THz spectral region. The THz bandpass filters based on stacked bilayer metasurfaces allow a fairly narrow, high-transmission passband, and a fast roll-off to an extremely clean background outside the passband, thereby providing superior bandpass performance. The demonstrated scheme of narrowband THz bandpass filtering is of great importance for a variety of applications where spectrally clean, high THz transmission over a narrow bandwidth is desired, such as THz spectroscopy and imaging, molecular detection and monitoring, security screening, and THz wireless communications.

E-ELT M5 field stabilisation unit scale 1 demonstrator design and performances evaluation

NASA Astrophysics Data System (ADS)

Casalta, J. M.; Barriga, J.; Ariño, J.; Mercader, J.; San Andrés, M.; Serra, J.; Kjelberg, I.; Hubin, N.; Jochum, L.; Vernet, E.; Dimmler, M.; Müller, M.

2010-07-01

The M5 Field stabilization Unit (M5FU) for European Extremely Large Telescope (E-ELT) is a fast correcting optical system that shall provide tip-tilt corrections for the telescope dynamic pointing errors and the effect of atmospheric tiptilt and wind disturbances. A M5FU scale 1 demonstrator (M5FU1D) is being built to assess the feasibility of the key elements (actuators, sensors, mirror, mirror interfaces) and the real-time control algorithm. The strict constraints (e.g. tip-tilt control frequency range 100Hz, 3m ellipse mirror size, mirror first Eigen frequency 300Hz, maximum tip/tilt range +/- 30 arcsec, maximum tiptilt error < 40 marcsec) have been a big challenge for developing the M5FU Conceptual Design and its scale 1 demonstrator. The paper summarises the proposed design for the final unit and demonstrator and the measured performances compared to the applicable specifications.

Interaction-induced decay of a heteronuclear two-atom system

PubMed Central

Xu, Peng; Yang, Jiaheng; Liu, Min; He, Xiaodong; Zeng, Yong; Wang, Kunpeng; Wang, Jin; Papoular, D. J.; Shlyapnikov, G. V.; Zhan, Mingsheng

2015-01-01

Two-atom systems in small traps are of fundamental interest for understanding the role of interactions in degenerate cold gases and for the creation of quantum gates in quantum information processing with single-atom traps. One of the key quantities is the inelastic relaxation (decay) time when one of the atoms or both are in a higher hyperfine state. Here we measure this quantity in a heteronuclear system of 87Rb and 85Rb in a micro optical trap and demonstrate experimentally and theoretically the presence of both fast and slow relaxation processes, depending on the choice of the initial hyperfine states. This experimental method allows us to single out a particular relaxation process thus provides an extremely clean platform for collisional physics studies. Our results have also implications for engineering of quantum states via controlled collisions and creation of two-qubit quantum gates. PMID:26199051

Invited Article: Narrowband terahertz bandpass filters employing stacked bilayer metasurface antireflection structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Chun-Chieh; Huang, Li; Nogan, John

We experimentally demonstrate high-performance narrowband terahertz (THz) bandpass filters through cascading multiple bilayer metasurface antireflection structures. Each bilayer metasurface, consisting of a square array of silicon pillars with a self-aligned top gold resonator-array and a complementary bottom gold slot-array, enables near-zero reflection and simultaneously close-to-unity single-band transmission at designed operational frequencies in the THz spectral region. The THz bandpass filters based on stacked bilayer metasurfaces allow a fairly narrow, high-transmission passband, and a fast roll-off to an extremely clean background outside the passband, thereby providing superior bandpass performance. The demonstrated scheme of narrowband THz bandpass filtering is of great importancemore » for a variety of applications where spectrally clean, high THz transmission over a narrow bandwidth is desired, such as THz spectroscopy and imaging, molecular detection and monitoring, security screening, and THz wireless communications.« less

Invited Article: Narrowband terahertz bandpass filters employing stacked bilayer metasurface antireflection structures

DOE PAGES

Chang, Chun-Chieh; Huang, Li; Nogan, John; ...

2018-02-01

We experimentally demonstrate high-performance narrowband terahertz (THz) bandpass filters through cascading multiple bilayer metasurface antireflection structures. Each bilayer metasurface, consisting of a square array of silicon pillars with a self-aligned top gold resonator-array and a complementary bottom gold slot-array, enables near-zero reflection and simultaneously close-to-unity single-band transmission at designed operational frequencies in the THz spectral region. The THz bandpass filters based on stacked bilayer metasurfaces allow a fairly narrow, high-transmission passband, and a fast roll-off to an extremely clean background outside the passband, thereby providing superior bandpass performance. The demonstrated scheme of narrowband THz bandpass filtering is of great importancemore » for a variety of applications where spectrally clean, high THz transmission over a narrow bandwidth is desired, such as THz spectroscopy and imaging, molecular detection and monitoring, security screening, and THz wireless communications.« less

Tomo3D 2.0--exploitation of advanced vector extensions (AVX) for 3D reconstruction.

PubMed

Agulleiro, Jose-Ignacio; Fernandez, Jose-Jesus

2015-02-01

Tomo3D is a program for fast tomographic reconstruction on multicore computers. Its high speed stems from code optimization, vectorization with Streaming SIMD Extensions (SSE), multithreading and optimization of disk access. Recently, Advanced Vector eXtensions (AVX) have been introduced in the x86 processor architecture. Compared to SSE, AVX double the number of simultaneous operations, thus pointing to a potential twofold gain in speed. However, in practice, achieving this potential is extremely difficult. Here, we provide a technical description and an assessment of the optimizations included in Tomo3D to take advantage of AVX instructions. Tomo3D 2.0 allows huge reconstructions to be calculated in standard computers in a matter of minutes. Thus, it will be a valuable tool for electron tomography studies with increasing resolution needs. Copyright © 2014 Elsevier Inc. All rights reserved.

Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): implications for biochemical biomarker assessment.

PubMed

Waugh, Courtney A; Huston, Wilhelmina M; Noad, Michael J; Bengtson Nash, Susan

2011-04-01

Large mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress. Copyright © 2011 Elsevier Ltd. All rights reserved.

Weighted least squares phase unwrapping based on the wavelet transform

NASA Astrophysics Data System (ADS)

Chen, Jiafeng; Chen, Haiqin; Yang, Zhengang; Ren, Haixia

2007-01-01

The weighted least squares phase unwrapping algorithm is a robust and accurate method to solve phase unwrapping problem. This method usually leads to a large sparse linear equation system. Gauss-Seidel relaxation iterative method is usually used to solve this large linear equation. However, this method is not practical due to its extremely slow convergence. The multigrid method is an efficient algorithm to improve convergence rate. However, this method needs an additional weight restriction operator which is very complicated. For this reason, the multiresolution analysis method based on the wavelet transform is proposed. By applying the wavelet transform, the original system is decomposed into its coarse and fine resolution levels and an equivalent equation system with better convergence condition can be obtained. Fast convergence in separate coarse resolution levels speeds up the overall system convergence rate. The simulated experiment shows that the proposed method converges faster and provides better result than the multigrid method.

Beam test results of STS prototype modules for the future accelerator experiments FAIR/CBM and NICA/MPD projects

NASA Astrophysics Data System (ADS)

Kharlamov, Petr; Dementev, Dmitrii; Shitenkov, Mikhail

2017-10-01

High-energy heavy-ion collision experiments provide the unique possibility to create and investigate extreme states of strongly-interacted matter and address the fundamental aspects of QCD. The experimental investigation the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. The reconstruction of the charged particles created in the nuclear collisions, including the determination of their momenta, is the central detection task in high-energy heavy-ion experiments. It is taken up by the Silicon Tracking System in CBM@FAIR and by Inner Tracker in MPD@NICA currently under development. These experiments requires very fast and radiation hard detectors, a novel data read-out and analysis concept including free streaming front-end electronics. Thermal and beam tests of prototype detector modules for these tracking systems showed the stability of sensors and readout electronics operation.

An intuitive two-fluid picture of spontaneous 2D collisionless magnetic reconnection and whistler wave generation

NASA Astrophysics Data System (ADS)

Yoon, Young Dae; Bellan, Paul M.

2018-05-01

An intuitive and physical two-fluid picture of spontaneous 2D collisionless magnetic reconnection and whistler wave generation is presented in the framework of 3D electron-magnetohydrodynamics. In this regime, canonical circulation (Q =me∇×u +qeB ) flux tubes can be defined in analogy to magnetic flux tubes in ideal magnetohydrodynamics. Following the 3D behavior of these Q flux tubes provides a new perspective on collisionless reconnection—a perspective that has been hard to perceive via examinations of 2D projections. This shows that even in a 2D geometry with an ignorable coordinate, a 3D examination is essential for a full comprehension of the process. Intuitive answers are given to three main questions in collisionless reconnection: why is reconnection spontaneous, why do particles accelerate extremely fast, and why are whistler waves generated? Possible extensions to other regimes are discussed.

Status of diamond particle detectors

NASA Astrophysics Data System (ADS)

Krammer, M.; Adam, W.; Bauer, C.; Berdermann, E.; Bogani, F.; Borchi, E.; Bruzzi, M.; Colledani, C.; Conway, J.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; van Eijk, B.; Fallou, A.; Fish, D.; Foulon, F.; Friedl, M.; Gan, K. K.; Gheeraert, E.; Grigoriev, E.; Hallewell, G.; Hall-Wilton, R.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Kass, R.; Knöpfle, K. T.; Manfredi, P. F.; Meier, D.; Mishina, M.; LeNormand, F.; Pan, L. S.; Pernegger, H.; Pernicka, M.; Re, V.; Riester, G. L.; Roe, S.; Roff, D.; Rudge, A.; Schnetzer, S.; Sciortino, S.; Speziali, V.; Stelzer, H.; Stone, R.; Tapper, R. J.; Tesarek, R.; Thomson, G. B.; Trawick, M.; Trischuk, W.; Turchetta, R.; Walsh, A. M.; Wedenig, R.; Weilhammer, P.; Ziock, H.; Zoeller, M.

1998-11-01

To continue the exciting research in the field of particle physics new accelerators and experiments are under construction. In some of these experiments, e.g. ATLAS and CMS at the Large Hadron Collider at CERN or HERA-B at DESY, the detectors have to withstand an extreme environment. The detectors must be radiation hard, provide a very fast signal, and be as thin as possible. The properties of CVD diamond allow to fulfill these requirements and make it an ideal material for the detectors close to the interaction region of these experiments, i.e. the vertex detectors or the inner trackers. The RD42 collaboration is developing diamond detectors for these applications. The program of RD42 includes the improvement of the charge collection properties of CVD diamond, the study of the radiation hardness and the development of low-noise radiation hard readout electronics. An overview of the progress achieved during the last years will be given.

[Prenatal risk calculation: comparison between Fast Screen pre I plus software and ViewPoint software. Evaluation of the risk calculation algorithms].

PubMed

Morin, Jean-François; Botton, Eléonore; Jacquemard, François; Richard-Gireme, Anouk

2013-01-01

The Fetal medicine foundation (FMF) has developed a new algorithm called Prenatal Risk Calculation (PRC) to evaluate Down syndrome screening based on free hCGβ, PAPP-A and nuchal translucency. The peculiarity of this algorithm is to use the degree of extremeness (DoE) instead of the multiple of the median (MoM). The biologists measuring maternal seric markers on Kryptor™ machines (Thermo Fisher Scientific) use Fast Screen pre I plus software for the prenatal risk calculation. This software integrates the PRC algorithm. Our study evaluates the data of 2.092 patient files of which 19 show a fœtal abnormality. These files have been first evaluated with the ViewPoint software based on MoM. The link between DoE and MoM has been analyzed and the different calculated risks compared. The study shows that Fast Screen pre I plus software gives the same risk results as ViewPoint software, but yields significantly fewer false positive results.

Autonomous celestial navigation based on Earth ultraviolet radiance and fast gradient statistic feature extraction

NASA Astrophysics Data System (ADS)

Lu, Shan; Zhang, Hanmo

2016-01-01

To meet the requirement of autonomous orbit determination, this paper proposes a fast curve fitting method based on earth ultraviolet features to obtain accurate earth vector direction, in order to achieve the high precision autonomous navigation. Firstly, combining the stable characters of earth ultraviolet radiance and the use of transmission model software of atmospheric radiation, the paper simulates earth ultraviolet radiation model on different time and chooses the proper observation band. Then the fast improved edge extracting method combined Sobel operator and local binary pattern (LBP) is utilized, which can both eliminate noises efficiently and extract earth ultraviolet limb features accurately. And earth's centroid locations on simulated images are estimated via the least square fitting method using part of the limb edges. Taken advantage of the estimated earth vector direction and earth distance, Extended Kalman Filter (EKF) is applied to realize the autonomous navigation finally. Experiment results indicate the proposed method can achieve a sub-pixel earth centroid location estimation and extremely enhance autonomous celestial navigation precision.

Understanding the Physical Nature of Coronal "EIT Waves"

NASA Astrophysics Data System (ADS)

Long, D. M.; Bloomfield, D. S.; Chen, P.-F.; Downs, C.; Gallagher, P. T.; Kwon, R.-Y.; Vanninathan, K.; Veronig, A.; Vourlidas, A.; Vrsnak, B.; Warmuth, A.; Zic, T.

2016-10-01

For almost 20 years the physical nature of globally-propagating waves in the solar corona (commonly called "EIT waves") has been controversial and subject to debate. Additional theories have been proposed throughout the years to explain observations that did not fit with the originally proposed fast-mode wave interpretation. However, the incompatibility of observations made using the Extreme-ultraviolet Imaging Telescope (EIT) on the Solar and Heliospheric Observatory with the fast-mode wave interpretation have been challenged by differing viewpoints from the Solar Terrestrial Relations Observatory spacecraft and higher spatial/temporal resolution data from the Solar Dynamics Observatory. In this paper, we reexamine the theories proposed to explain "EIT waves" to identify measurable properties and behaviours that can be compared to current and future observations. Most of us conclude that "EIT waves" are best described as fast-mode large-amplitude waves/shocks, which are initially driven by the impulsive expansion of an erupting coronal mass ejection in the low corona.

Fast and Epsilon-Optimal Discretized Pursuit Learning Automata.

PubMed

Zhang, JunQi; Wang, Cheng; Zhou, MengChu

2015-10-01

Learning automata (LA) are powerful tools for reinforcement learning. A discretized pursuit LA is the most popular one among them. During an iteration its operation consists of three basic phases: 1) selecting the next action; 2) finding the optimal estimated action; and 3) updating the state probability. However, when the number of actions is large, the learning becomes extremely slow because there are too many updates to be made at each iteration. The increased updates are mostly from phases 1 and 3. A new fast discretized pursuit LA with assured ε -optimality is proposed to perform both phases 1 and 3 with the computational complexity independent of the number of actions. Apart from its low computational complexity, it achieves faster convergence speed than the classical one when operating in stationary environments. This paper can promote the applications of LA toward the large-scale-action oriented area that requires efficient reinforcement learning tools with assured ε -optimality, fast convergence speed, and low computational complexity for each iteration.

Understanding the Physical Nature of Coronal "EIT Waves".

PubMed

Long, D M; Bloomfield, D S; Chen, P F; Downs, C; Gallagher, P T; Kwon, R-Y; Vanninathan, K; Veronig, A M; Vourlidas, A; Vršnak, B; Warmuth, A; Žic, T

2017-01-01

For almost 20 years the physical nature of globally propagating waves in the solar corona (commonly called "EIT waves") has been controversial and subject to debate. Additional theories have been proposed over the years to explain observations that did not agree with the originally proposed fast-mode wave interpretation. However, the incompatibility of observations made using the Extreme-ultraviolet Imaging Telescope (EIT) onboard the Solar and Heliospheric Observatory with the fast-mode wave interpretation was challenged by differing viewpoints from the twin Solar Terrestrial Relations Observatory spacecraft and data with higher spatial and temporal resolution from the Solar Dynamics Observatory . In this article, we reexamine the theories proposed to explain EIT waves to identify measurable properties and behaviours that can be compared to current and future observations. Most of us conclude that the so-called EIT waves are best described as fast-mode large-amplitude waves or shocks that are initially driven by the impulsive expansion of an erupting coronal mass ejection in the low corona.

Scalloping minimization in deep Si etching on Unaxis DSE tools

NASA Astrophysics Data System (ADS)

Lai, Shouliang; Johnson, Dave J.; Westerman, Russ J.; Nolan, John J.; Purser, David; Devre, Mike

2003-01-01

Sidewall smoothness is often a critical requirement for many MEMS devices, such as microfludic devices, chemical, biological and optical transducers, while fast silicon etch rate is another. For such applications, the time division multiplex (TDM) etch processes, so-called "Bosch" processes are widely employed. However, in the conventional TDM processes, rough sidewalls result due to scallop formation. To date, the amplitude of the scalloping has been directly linked to the silicon etch rate. At Unaxis USA Inc., we have developed a proprietary fast gas switching technique that is effective for scalloping minimization in deep silicon etching processes. In this technique, process cycle times can be reduced from several seconds to as little as a fraction of second. Scallop amplitudes can be reduced with shorter process cycles. More importantly, as the scallop amplitude is progressively reduced, the silicon etch rate can be maintained relatively constant at high values. An optimized experiment has shown that at etch rate in excess of 7 μm/min, scallops with length of 116 nm and depth of 35 nm were obtained. The fast gas switching approach offers an ideal manufacturing solution for MEMS applications where extremely smooth sidewall and fast etch rate are crucial.

Development of UO2/PuO2 dispersed in uranium matrix CERMET fuel system for fast reactors

NASA Astrophysics Data System (ADS)

Sinha, V. P.; Hegde, P. V.; Prasad, G. J.; Pal, S.; Mishra, G. P.

2012-08-01

CERMET fuel with either PuO2 or enriched UO2 dispersed in uranium metal matrix has a strong potential of becoming a fuel for the liquid metal cooled fast breeder reactors (LMR's). In fact it may act as a bridge between the advantages and disadvantages associated with the two extremes of fuel systems (i.e. ceramic fuel and metallic fuel) for fast reactors. At Bhabha Atomic Research Centre (BARC), R & D efforts are on to develop this CERMET fuel by powder metallurgy route. This paper describes the development of flow sheet for preparation of UO2 dispersed in uranium metal matrix pellets for three different compositions i.e. U-20 wt%UO2, U-25 wt%UO2 and U-30 wt%UO2. It was found that the sintered pellets were having excellent integrity and their linear mass was higher than that of carbide fuel pellets used in Fast Breeder Test Reactor programme (FBTR) in India. The pellets were characterized by X-ray diffraction (XRD) technique for phase analysis and lattice parameter determination. The optical microstructures were developed and reported for all the three different U-UO2 compositions.

Single-molecule, full-length transcript sequencing provides insight into the extreme metabolism of the ruby-throated hummingbird Archilochus colubris.

PubMed

Workman, Rachael E; Myrka, Alexander M; Wong, G William; Tseng, Elizabeth; Welch, Kenneth C; Timp, Winston

2018-03-01

Hummingbirds oxidize ingested nectar sugars directly to fuel foraging but cannot sustain this fuel use during fasting periods, such as during the night or during long-distance migratory flights. Instead, fasting hummingbirds switch to oxidizing stored lipids that are derived from ingested sugars. The hummingbird liver plays a key role in moderating energy homeostasis and this remarkable capacity for fuel switching. Additionally, liver is the principle location of de novo lipogenesis, which can occur at exceptionally high rates, such as during premigratory fattening. Yet understanding how this tissue and whole organism moderates energy turnover is hampered by a lack of information regarding how relevant enzymes differ in sequence, expression, and regulation. We generated a de novo transcriptome of the hummingbird liver using PacBio full-length cDNA sequencing (Iso-Seq), yielding 8.6Gb of sequencing data, or 2.6M reads from 4 different size fractions. We analyzed data using the SMRTAnalysis v3.1 Iso-Seq pipeline, then clustered isoforms into gene families to generate de novo gene contigs using Cogent. We performed orthology analysis to identify closely related sequences between our transcriptome and other avian and human gene sets. Finally, we closely examined homology of critical lipid metabolism genes between our transcriptome data and avian and human genomes. We confirmed high levels of sequence divergence within hummingbird lipogenic enzymes, suggesting a high probability of adaptive divergent function in the hepatic lipogenic pathways. Our results leverage cutting-edge technology and a novel bioinformatics pipeline to provide a first direct look at the transcriptome of this incredible organism.

Providing Calorie Information on Fast-Food Restaurant Menu Boards: Consumer Views

PubMed Central

Fitch, Rebecca C.; Harnack, Lisa J.; Neumark-Sztainer, Dianne R.; Story, Mary T.; French, Simone A.; Oakes, J. Michael; Rydell, Sarah A.

2010-01-01

Purpose To gather consumer input about approaches to providing energy composition information for foods on fast-food restaurant menus. Design We asked a subset of individuals (n = 150) in an experimental study about the influence of nutrition labeling on fast-food meal choices to evaluate calorie information on mock fast-food menus in various formats. Setting Three community sites in the Minneapolis-St. Paul, Minnesota, metropolitan area. Subjects Adolescents and adults who ate fast food at least once per week were recruited. Measures Via a series of open- and close-ended questions, participants gave feedback about several formats for providing energy composition information for foods on fast-food restaurant menus. Analysis Means and frequencies were calculated, and χ2 tests were conducted. Results When asked to compare a menu that provided calorie information for each menu item with a menu that provided the number of minutes of running that would be required to burn the calories contained in each menu item, 71.0% of participants preferred the calorie information over the physical activity information. Participants also compared two approaches to providing caloric reference information on the menu (average daily calorie needs per day vs. per meal), and 61.3% preferred the calorie needs–per-meal format. Conclusion Our results may be useful in designing approaches to providing energy composition information for foods on fast-food restaurant menus. PMID:19928485

The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia.

PubMed

Durstewitz, Daniel; Seamans, Jeremy K

2008-11-01

There is now general consensus that at least some of the cognitive deficits in schizophrenia are related to dysfunctions in the prefrontal cortex (PFC) dopamine (DA) system. At the cellular and synaptic level, the effects of DA in PFC via D1- and D2-class receptors are highly complex, often apparently opposing, and hence difficult to understand with regard to their functional implications. Biophysically realistic computational models have provided valuable insights into how the effects of DA on PFC neurons and synaptic currents as measured in vitro link up to the neural network and cognitive levels. They suggest the existence of two discrete dynamical regimes, a D1-dominated state characterized by a high energy barrier among different network patterns that favors robust online maintenance of information and a D2-dominated state characterized by a low energy barrier that is beneficial for flexible and fast switching among representational states. These predictions are consistent with a variety of electrophysiological, neuroimaging, and behavioral results in humans and nonhuman species. Moreover, these biophysically based models predict that imbalanced D1:D2 receptor activation causing extremely low or extremely high energy barriers among activity states could lead to the emergence of cognitive, positive, and negative symptoms observed in schizophrenia. Thus, combined experimental and computational approaches hold the promise of allowing a detailed mechanistic understanding of how DA alters information processing in normal and pathological conditions, thereby potentially providing new routes for the development of pharmacological treatments for schizophrenia.

A study of transonic aerodynamic analysis methods for use with a hypersonic aircraft synthesis code

NASA Technical Reports Server (NTRS)

Sandlin, Doral R.; Davis, Paul Christopher

1992-01-01

A means of performing routine transonic lift, drag, and moment analyses on hypersonic all-body and wing-body configurations were studied. The analysis method is to be used in conjunction with the Hypersonic Vehicle Optimization Code (HAVOC). A review of existing techniques is presented, after which three methods, chosen to represent a spectrum of capabilities, are tested and the results are compared with experimental data. The three methods consist of a wave drag code, a full potential code, and a Navier-Stokes code. The wave drag code, representing the empirical approach, has very fast CPU times, but very limited and sporadic results. The full potential code provides results which compare favorably to the wind tunnel data, but with a dramatic increase in computational time. Even more extreme is the Navier-Stokes code, which provides the most favorable and complete results, but with a very large turnaround time. The full potential code, TRANAIR, is used for additional analyses, because of the superior results it can provide over empirical and semi-empirical methods, and because of its automated grid generation. TRANAIR analyses include an all body hypersonic cruise configuration and an oblique flying wing supersonic transport.

Dual redundant display in bubble canopy applications

NASA Astrophysics Data System (ADS)

Mahdi, Ken; Niemczyk, James

2010-04-01

Today's cockpit integrator, whether for state of the art military fast jet, or piston powered general aviation, is striving to utilize all available panel space for AMLCD based displays to enhance situational awareness and increase safety. The benefits of a glass cockpit have been well studied and documented. The technology used to create these glass cockpits, however, is driven by commercial AMLCD demand which far outstrips the combined worldwide avionics requirements. In order to satisfy the wide variety of human factors and environmental requirements, large area displays have been developed to maximize the usable display area while also providing necessary redundancy in case of failure. The AMLCD has been optimized for extremely wide viewing angles driven by the flat panel TV market. In some cockpit applications, wide viewing cones are desired. In bubble canopy cockpits, however, narrow viewing cones are desired to reduce canopy reflections. American Panel Corporation has developed AMLCD displays that maximize viewing area, provide redundancy, while also providing a very narrow viewing cone even though commercial AMLCD technology is employed suitable for high performance AMLCD Displays. This paper investigates both the large area display architecture with several available options to solve redundancy as well as beam steering techniques to also limit canopy reflections.

High-resolution stochastic generation of extreme rainfall intensity for urban drainage modelling applications

NASA Astrophysics Data System (ADS)

Peleg, Nadav; Blumensaat, Frank; Molnar, Peter; Fatichi, Simone; Burlando, Paolo

2016-04-01

Urban drainage response is highly dependent on the spatial and temporal structure of rainfall. Therefore, measuring and simulating rainfall at a high spatial and temporal resolution is a fundamental step to fully assess urban drainage system reliability and related uncertainties. This is even more relevant when considering extreme rainfall events. However, the current space-time rainfall models have limitations in capturing extreme rainfall intensity statistics for short durations. Here, we use the STREAP (Space-Time Realizations of Areal Precipitation) model, which is a novel stochastic rainfall generator for simulating high-resolution rainfall fields that preserve the spatio-temporal structure of rainfall and its statistical characteristics. The model enables a generation of rain fields at 102 m and minute scales in a fast and computer-efficient way matching the requirements for hydrological analysis of urban drainage systems. The STREAP model was applied successfully in the past to generate high-resolution extreme rainfall intensities over a small domain. A sub-catchment in the city of Luzern (Switzerland) was chosen as a case study to: (i) evaluate the ability of STREAP to disaggregate extreme rainfall intensities for urban drainage applications; (ii) assessing the role of stochastic climate variability of rainfall in flow response and (iii) evaluate the degree of non-linearity between extreme rainfall intensity and system response (i.e. flow) for a small urban catchment. The channel flow at the catchment outlet is simulated by means of a calibrated hydrodynamic sewer model.

Blue storms depress growth of shortleaf pine in western Arkansas and eastern Oklahoma

Treesearch

Douglas J. Stevenson; Thomas B. Lynch; James M. Guldin

2012-01-01

Climate and weather, especially storms, have major effects on trees. Fast moving “Alberta Clippers,” or Blue Storms, that produce extreme cold and little precipitation happen each year on the Great Plains in association with Chinook winds in the Northern and Central Rockies. When these storms occur between February 13th and March 10th when shortleaf pines on the...

Escalation and Resolution of Border Disputes and Interstate Conflicts in Africa: The Malawi-Tanzania Case

DTIC Science & Technology

2011-06-01

struggle in the region. They cause relentless strife, including refugee problems, environmental degradation, deforestation , small arms proliferation...human and natural resources, extreme poverty and hunger abound on the continent.”42 Furthermore, a snapshot of Africa reveals deforestation , fast...Malawi, while Tanzania is disadvantaged . Since players selfishly attempt to maximize their outcomes, via ‘maximin theorem,’ the outcome is BD that

Extremely fast increase in the organic loading rate during the co-digestion of rapeseed oil and sewage sludge in a CSTR--characterization of granules formed due to CaO addition to maintain process stability.

PubMed

Kasina, M; Kleyböcker, A; Michalik, M; Würdemann, H

2015-01-01

In a co-digestion system running with rapeseed oil and sewage sludge, an extremely fast increase in the organic loading rate was studied to develop a procedure to allow for flexible and demand-driven energy production. The over-acidification of the digestate was successfully prevented by calcium oxide dosage, which resulted in granule formation. Mineralogical analyses revealed that the granules were composed of insoluble salts of long chain fatty acids and calcium and had a porous structure. Long chain fatty acids and calcium formed the outer cover of granules and offered interfaces on the inside thereby enhancing the growth of biofilms. With granule size and age, the pore size increased and indicated degradation of granular interfaces. A stable biogas production up to the organic loading rate of 10.4 kg volatile solids m(-3) d(-1) was achieved although the hydrogen concentration was not favorable for propionic acid degradation. However, at higher organic loading rates, unbalanced granule formation and degradation were observed. Obviously, the adaption time for biofilm growth was too short to maintain the balance, thereby resulting in a low methane yield.

Holographic Adaptive Laser Optics System (HALOS): Fast, Autonomous Aberration Correction

NASA Astrophysics Data System (ADS)

Andersen, G.; MacDonald, K.; Gelsinger-Austin, P.

2013-09-01

We present an adaptive optics system which uses a multiplexed hologram to deconvolve the phase aberrations in an input beam. This wavefront characterization is extremely fast as it is based on simple measurements of the intensity of focal spots and does not require any computations. Furthermore, the system does not require a computer in the loop and is thus much cheaper, less complex and more robust as well. A fully functional, closed-loop prototype incorporating a 32-element MEMS mirror has been constructed. The unit has a footprint no larger than a laptop but runs at a bandwidth of 100kHz over an order of magnitude faster than comparable, conventional systems occupying a significantly larger volume. Additionally, since the sensing is based on parallel, all-optical processing, the speed is independent of actuator number running at the same bandwidth for one actuator as for a million. We are developing the HALOS technology with a view towards next-generation surveillance systems for extreme adaptive optics applications. These include imaging, lidar and free-space optical communications for unmanned aerial vehicles and SSA. The small volume is ideal for UAVs, while the high speed and high resolution will be of great benefit to the ground-based observation of space-based objects.

Magnetic field generation, Weibel-mediated collisionless shocks, and magnetic reconnection in colliding laser-produced plasmas

NASA Astrophysics Data System (ADS)

Fox, W.; Bhattacharjee, A.; Fiksel, G.

2016-10-01

Colliding plasmas are ubiquitous in astrophysical environments and allow conversion of kinetic energy into heat and, most importantly, the acceleration of particles to extremely high energies to form the cosmic ray spectrum. In collisionless astrophysical plasmas, kinetic plasma processes govern the interaction and particle acceleration processes, including shock formation, self-generation of magnetic fields by kinetic plasma instabilities, and magnetic field compression and reconnection. How each of these contribute to the observed spectra of cosmic rays is not fully understood, in particular both shock acceleration processes and magnetic reconnection have been proposed. We will review recent results of laboratory astrophysics experiments conducted at high-power, inertial-fusion-class laser facilities, which have uncovered significant results relevant to these processes. Recent experiments have now observed the long-sought Weibel instability between two interpenetrating high temperature plasma plumes, which has been proposed to generate the magnetic field necessary for shock formation in unmagnetized regimes. Secondly, magnetic reconnection has been studied in systems of colliding plasmas using either self-generated magnetic fields or externally applied magnetic fields, and show extremely fast reconnection rates, indicating fast destruction of magnetic energy and further possibilities to accelerate particles. Finally, we highlight kinetic plasma simulations, which have proven to be essential tools in the design and interpretation of these experiments.

Robust efficient video fingerprinting

NASA Astrophysics Data System (ADS)

Puri, Manika; Lubin, Jeffrey

2009-02-01

We have developed a video fingerprinting system with robustness and efficiency as the primary and secondary design criteria. In extensive testing, the system has shown robustness to cropping, letter-boxing, sub-titling, blur, drastic compression, frame rate changes, size changes and color changes, as well as to the geometric distortions often associated with camcorder capture in cinema settings. Efficiency is afforded by a novel two-stage detection process in which a fast matching process first computes a number of likely candidates, which are then passed to a second slower process that computes the overall best match with minimal false alarm probability. One key component of the algorithm is a maximally stable volume computation - a three-dimensional generalization of maximally stable extremal regions - that provides a content-centric coordinate system for subsequent hash function computation, independent of any affine transformation or extensive cropping. Other key features include an efficient bin-based polling strategy for initial candidate selection, and a final SIFT feature-based computation for final verification. We describe the algorithm and its performance, and then discuss additional modifications that can provide further improvement to efficiency and accuracy.

Robust G2 pausing of adult stem cells in Hydra.

PubMed

Buzgariu, Wanda; Crescenzi, Marco; Galliot, Brigitte

2014-01-01

Hydra is a freshwater hydrozoan polyp that constantly renews its two tissue layers thanks to three distinct stem cell populations that cannot replace each other, epithelial ectodermal, epithelial endodermal, and multipotent interstitial. These adult stem cells, located in the central body column, exhibit different cycling paces, slow for the epithelial, fast for the interstitial. To monitor the changes in cell cycling in Hydra, we established a fast and efficient flow cytometry procedure, which we validated by confirming previous findings, as the Nocodazole-induced reversible arrest of cell cycling in G2/M, and the mitogenic signal provided by feeding. Then to dissect the cycling and differentiation behaviors of the interstitial stem cells, we used the AEP_cnnos1 and AEP_Icy1 transgenic lines that constitutively express GFP in this lineage. For the epithelial lineages we used the sf-1 strain that rapidly eliminates the fast cycling cells upon heat-shock and progressively becomes epithelial. This study evidences similar cycling patterns for the interstitial and epithelial stem cells, which all alternate between the G2 and S-phases traversing a minimal G1-phase. We also found interstitial progenitors with a shorter G2 that pause in G1/G0. At the animal extremities, most cells no longer cycle, the epithelial cells terminally differentiate in G2 and the interstitial progenitors in G1/G0. At the apical pole ~80% cells are post-mitotic differentiated cells, reflecting the higher density of neurons and nematocytes in this region. We discuss how the robust G2 pausing of stem cells, maintained over weeks of starvation, may contribute to regeneration. Copyright © 2014 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

A challenge to dSph formation models: are the most isolated Local Group dSph galaxies truly old?

NASA Astrophysics Data System (ADS)

Monelli, Matteo

2017-08-01

What is the origin of the different dwarf galaxy types? The classification into dwarf irregular (dIrr), spheroidal (dSph), and transition (dT) types is based on their present-day properties. However, star formation histories (SFHs) reconstructed from deep color-magnitude diagrams (CMDs) provide details on the early evolution of galaxies of all these types, and indicate only two basic evolutionary paths. One is characterized by a vigorous but brief initial star-forming event, and little or no star formation thereafter (fast evolution), and the other one by roughly continuous star formation until (nearly) the present time (slow evolution). These two paths do not map directly onto the dIrr, dT and dSph types. Thus, the present galaxy properties do not reflect their lifetime evolution. Since there are some indications that slow dwarfs were assembled in lower-density environments than fast dwarfs, Gallart et al (2015) proposed that the distinction between fast and slow dwarfs reflects the characteristic density of the environment where they formed. This scenario, and more generally scenarios where dSph galaxies formed through the interaction with a massive galaxy, are challenged by a small sample of extremely isolated dSph/dT in the outer fringes of the Local Group. This proposal targets two of these objects (VV124, KKR25) for which we will infer their SFH - through a novel technique that combines the information from their RR Lyrae stars and deep CMDs sampling the intermediate-age population - in order to test these scenarios. This is much less demanding on observing time than classical SFH derivation using full depth CMDs.

Asymptotic domination of cold relativistic MHD winds by kinetic energy flux

NASA Technical Reports Server (NTRS)

Begelman, Mitchell C.; Li, Zhi-Yun

1994-01-01

We study the conditions which lead to the conversion of most Poynting flux into kinetic energy flux in cold, relativistic hydromagnetic winds. It is shown that plasma acceleration along a precisely radial flow is extremely inefficient due to the near cancellation of the toroidal magnetic pressure and tension forces. However, if the flux tubes in a flow diverge even slightly faster than radially, the fast magnetosonic point moves inward from infinity to a few times the light cylinder radius. Once the flow becomes supermagnetosonic, further divergence of the flux tubes beyond the fast point can accelerate the flow via the 'magnetic nozzle' effect, thereby further converting Poynting flux to kinetic energy flux. We show that the Grad-Shafranov equation admits a generic family of kinetic energy-dominated asymptotic wind solutions with finite total magnetic flux. The Poynting flux in these solutions vanishes logarithmically with distance. The way in which the flux surfaces are nested within the flow depends only on the ratio of angular velocity to poliodal 4-velocity as a function of magnetic flux. Radial variations in flow structure can be expressed in terms of a pressure boundary condition on the outermost flux surface, provided that no external toriodal field surrounds the flow. For a special case, we show explicitly how the flux surfaces merge gradually to their asymptotes. For flows confined by an external medium of pressure decreasing to zero at infinity we show that, depending on how fast the ambient pressure declines, the final flow state could be either a collimated jet or a wind that fills the entire space. We discuss the astrophysical implications of our results for jets from active galactic nuclei and for free pulsar winds such as that believed to power the Crab Nebula.

In Vivo Measurement in Pigs of Wash-In Kinetics of Xenon at its Site of Action.

PubMed

Froeba, Gebhard; Adolph, Oliver

2016-01-01

Xenon (Xe) in many respects is an ideal anaesthetic agent. Its blood/gas partition coefficient is lower than that of any other anaesthetic, enabling rapid induction of and emergence from anaesthesia. While the whole body kinetics during wash-in of inhalational anaesthesia is well known, data describing the pharmacokinetics of xenon in the cerebral compartment at the site of action are still largely missing. In order to illuminate xenon's cerebral pharmacokinetics, we anaesthetised five pigs and measured arterial, mixed- and sagittal sinus-venous blood, as well as end-expiratory gas concentrations of xenon by gas chromatography-mass spectrometry (GCMS) up to 30 minutes after starting the anaesthetic gas mixture. Despite xenon's fast onset of effect the half-time for equilibration between xenon concentration in arterial blood and at the site of action is measured to be 1.49 ± 0.04 minutes versus 3.91 ± 0.1 minutes. Successful loading of xenon in the brain during inhalational anesthesia was accomplished after approximately 15 minutes although the end-expiratory xenon concentration reached a plateau after 7 minutes. Thus cerebral xenon uptake rate is only moderate, xenon fast onset of action being largely due to its extremely fast alveolar uptake. To ensure safety and precise control during anaesthesia we need a profound knowledge about to what extent the measured end-tidal concentrations reflect the drug concentrations in the target tissue. The results of this study expand our knowledge about the temporal characteristics of xenon´s pharmacokinetics at its site of action and provide the basis for appropriate clinical protocols and experimental designs of future studies.

BAL QSOs AND EXTREME UFOs: THE EDDINGTON CONNECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zubovas, Kastytis; King, Andrew, E-mail: kastytis.zubovas@ftmc.lt

We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to {approx}10-50 times this in BAL QSOs. For UFOs this implies black holemore » accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-{sigma} relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.« less

BAL QSOs and Extreme UFOs: The Eddington Connection

NASA Astrophysics Data System (ADS)

Zubovas, Kastytis; King, Andrew

2013-05-01

We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to ~10-50 times this in BAL QSOs. For UFOs this implies black hole accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-σ relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.

Muslim patients' expectations and attitudes about Ramadan fasting during pregnancy.

PubMed

Lou, Alina; Hammoud, Maya

2016-03-01

To investigate Muslim women's attitudes concerning Ramadan fasting during pregnancy and determine how healthcare providers can better serve this population. A cross-sectional study targeted Muslim patients with active obstetric records within the University of Michigan Health System who received care at clinics in metro Detroit (MI, USA) during Ramadan in 2013. Patients aged 18-50 years were approached between July 7 and August 15, and asked to complete a written survey on perceptions of fasting, influences on decision making, and healthcare expectations. Among the 37 women who completed the survey, 26 (70%) did not fast in their current or most recent pregnancy during Ramadan. Overall, 23 (62%) women believed that fasting was harmful to themselves, their fetus, or both. Seven (19%) women reported consulting others about fasting during pregnancy, with the most influential individuals being Muslim scholars, followed by family/relatives and healthcare providers. The most important characteristics desired in a physician included being respectful of Islamic beliefs and possessing knowledge about Ramadan. Most women chose not to fast during pregnancy. Although few consulted healthcare providers, pregnant Muslim women valued their opinions. Healthcare providers need to educate themselves about which topics to discuss with Muslim patients to provide care on an individual basis. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice.

PubMed

Buschemeyer, W Cooper; Klink, Joseph C; Mavropoulos, John C; Poulton, Susan H; Demark-Wahnefried, Wendy; Hursting, Stephen D; Cohen, Pinchas; Hwang, David; Johnson, Tracy L; Freedland, Stephen J

2010-07-01

Caloric restriction (CR) delays cancer growth in animals, though translation to humans is difficult. We hypothesized intermittent fasting (i.e., intermittent extreme CR), may be better tolerated and prolong survival of prostate cancer (CaP) bearing mice. We conducted a pilot study by injecting 105 male individually-housed SCID mice with LAPC-4 cells. When tumors reached 200 mm(3), 15 mice/group were randomized to one of seven diets and sacrificed when tumors reached 1,500 mm(3): Group 1: ad libitum 7 days/week; Group 2: fasted 1 day/week and ad libitum 6 days/week; Group 3: fasted 1 day/week and fed 6 days/week via paired feeding to maintain isocaloric conditions to Group 1; Group 4: 14% CR 7 days/week; Group 5: fasted 2 days/week and ad libitum 5 days/week; Group 6: fasted 2 day/week and fed 5 days/week via paired feeding to maintain isocaloric conditions to Group 1; Group 7: 28% CR 7 days/week. Sera from mice at sacrifice were analyzed for IGF-axis hormones. There were no significant differences in survival among any groups. However, relative to Group 1, there were non-significant trends for improved survival for Groups 3 (HR 0.65, P = 0.26), 5 (0.60, P = 0.18), 6 (HR 0.59, P = 0.16), and 7 (P = 0.59, P = 0.17). Relative to Group 1, body weights and IGF-1 levels were significantly lower in Groups 6 and 7. This exploratory study found non-significant trends toward improved survival with some intermittent fasting regimens, in the absence of weight loss. Larger appropriately powered studies to detect modest, but clinically important differences are necessary to confirm these findings.

Bismuth molybdate thick films as ethanol sensor

NASA Astrophysics Data System (ADS)

Jain, Kiran; Kumar, Vipin; Gupta, H. P.; Rastogi, A. C.

2003-10-01

Ethanol sensitivity of bismuth molybdate thick films and sintered pellets were investigated. Sintered pellets were prepared by traditional ceramic processing. Thick films were prepared by metallorganic decomposition process. Ethanol gas sensitivity was measured at various temperatures and concentrations. Thick films of alpha phase bismuth molybdate prepared by spray pyrolysis showed a very fast response to ethanol detection. The response time for the bulk samples is about 40 sec which decreased to about 6 sec for thick films at an operating temperature of 300°C. An extremely low level approximately 10 ppm detection and fast response makes this technique ideal for sensor element fabrication for detection and estimation of alcohol in breath-analyzer. Unlike SnO2, the resistance of these sensors is not affected by humidity at the operating temperature.

Blind detection of isolated astrophysical pulses in the spatial Fourier transform domain

NASA Astrophysics Data System (ADS)

Schmid, Natalia A.; Prestage, Richard M.

2018-07-01

We present a novel approach for the detection of isolated transients in pulsar surveys and fast radio transient observations. Rather than the conventional approach of performing a computationally expensive blind dispersion measure search, we take the spatial Fourier transform (SFT) of short (˜ few seconds) sections of data. A transient will have a characteristic signature in the SFT domain, and we present a blind statistic which may be used to detect this signature at an empirical zero false alarm rate. The method has been evaluated using simulations, and also applied to two fast radio burst observations. In addition to its use for current observations, we expect this method will be extremely beneficial for future multibeam observations made by telescopes equipped with phased array feeds.

Blind detection of isolated astrophysical pulses in the spatial Fourier transform domain

NASA Astrophysics Data System (ADS)

Schmid, Natalia A.; Prestage, Richard M.

2018-04-01

We present a novel approach for the detection of isolated transients in pulsar surveys and fast radio transient observations. Rather than the conventional approach of performing a computationally expensive blind DM search, we take the spatial Fourier transform (SFT) of short (˜ few seconds) sections of data. A transient will have a characteristic signature in the SFT domain, and we present a blind statistic which may be used to detect this signature at an empirical zero False Alarm Rate (FAR). The method has been evaluated using simulations, and also applied to two fast radio burst observations. In addition to its use for current observations, we expect this method will be extremely beneficial for future multi-beam observations made by telescopes equipped with phased array feeds.

SANSparallel: interactive homology search against Uniprot.

PubMed

Somervuo, Panu; Holm, Liisa

2015-07-01

Proteins evolve by mutations and natural selection. The network of sequence similarities is a rich source for mining homologous relationships that inform on protein structure and function. There are many servers available to browse the network of homology relationships but one has to wait up to a minute for results. The SANSparallel webserver provides protein sequence database searches with immediate response and professional alignment visualization by third-party software. The output is a list, pairwise alignment or stacked alignment of sequence-similar proteins from Uniprot, UniRef90/50, Swissprot or Protein Data Bank. The stacked alignments are viewed in Jalview or as sequence logos. The database search uses the suffix array neighborhood search (SANS) method, which has been re-implemented as a client-server, improved and parallelized. The method is extremely fast and as sensitive as BLAST above 50% sequence identity. Benchmarks show that the method is highly competitive compared to previously published fast database search programs: UBLAST, DIAMOND, LAST, LAMBDA, RAPSEARCH2 and BLAT. The web server can be accessed interactively or programmatically at http://ekhidna2.biocenter.helsinki.fi/cgi-bin/sans/sans.cgi. It can be used to make protein functional annotation pipelines more efficient, and it is useful in interactive exploration of the detailed evidence supporting the annotation of particular proteins of interest. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

PERF: an exhaustive algorithm for ultra-fast and efficient identification of microsatellites from large DNA sequences.

PubMed

Avvaru, Akshay Kumar; Sowpati, Divya Tej; Mishra, Rakesh Kumar

2018-03-15

Microsatellites or Simple Sequence Repeats (SSRs) are short tandem repeats of DNA motifs present in all genomes. They have long been used for a variety of purposes in the areas of population genetics, genotyping, marker-assisted selection and forensics. Numerous studies have highlighted their functional roles in genome organization and gene regulation. Though several tools are currently available to identify SSRs from genomic sequences, they have significant limitations. We present a novel algorithm called PERF for extremely fast and comprehensive identification of microsatellites from DNA sequences of any size. PERF is several fold faster than existing algorithms and uses up to 5-fold lesser memory. It provides a clean and flexible command-line interface to change the default settings, and produces output in an easily-parseable tab-separated format. In addition, PERF generates an interactive and stand-alone HTML report with charts and tables for easy downstream analysis. PERF is implemented in the Python programming language. It is freely available on PyPI under the package name perf_ssr, and can be installed directly using pip or easy_install. The documentation of PERF is available at https://github.com/rkmlab/perf. The source code of PERF is deposited in GitHub at https://github.com/rkmlab/perf under an MIT license. tej@ccmb.res.in. Supplementary data are available at Bioinformatics online.

Women with fibromyalgia walk with an altered muscle synergy.

PubMed

Pierrynowski, Michael R; Tiidus, Peter M; Galea, Victoria

2005-11-01

Most individuals can use different movement and muscle recruitment patterns to perform a stated task but often only one pattern is selected which optimizes an unknown global objective given the individual's neuromusculoskeletal characteristics. Patients with fibromyalgia syndrome (FS), characterized by their chronic pain, reduced physical work capacity and muscular fatigue, could exhibit a different control signature compared to asymptomatic control volunteers (CV). To test this proposal, 22 women with FS, and 11 CV, were assessed in a gait analysis laboratory. Each subject walked repeatedly at self-selected slow, comfortable, and fast walking speeds. The gait analysis provided, for each walk, each subject's stride time, length, and velocity, and ground reaction force, and lower extremity joint kinematics, moments and powers. The data were then anthropometrically scaled and velocity normalized to reduce the influence of subject mass, leg length, and walking speed on the measured gait outcomes. Similarities and differences in the two groups' scaled and normalized gait patterns were then determined. Results show that FS and CV walk with externally similar stride lengths, times, and velocities, and joint angles and ground reaction forces but they use internally different muscle recruitment patterns. Specifically, FS preferentially power gait using their hip flexors instead of their ankle plantarflexors. Interestingly, CV use a similar muscle fatiguing recruitment pattern to walk fast which parallels the common complaint of fatigue reported by FS walking at comfortable speed.

Fast and Accurate Poisson Denoising With Trainable Nonlinear Diffusion.

PubMed

Feng, Wensen; Qiao, Peng; Chen, Yunjin; Wensen Feng; Peng Qiao; Yunjin Chen; Feng, Wensen; Chen, Yunjin; Qiao, Peng

2018-06-01

The degradation of the acquired signal by Poisson noise is a common problem for various imaging applications, such as medical imaging, night vision, and microscopy. Up to now, many state-of-the-art Poisson denoising techniques mainly concentrate on achieving utmost performance, with little consideration for the computation efficiency. Therefore, in this paper we aim to propose an efficient Poisson denoising model with both high computational efficiency and recovery quality. To this end, we exploit the newly developed trainable nonlinear reaction diffusion (TNRD) model which has proven an extremely fast image restoration approach with performance surpassing recent state-of-the-arts. However, the straightforward direct gradient descent employed in the original TNRD-based denoising task is not applicable in this paper. To solve this problem, we resort to the proximal gradient descent method. We retrain the model parameters, including the linear filters and influence functions by taking into account the Poisson noise statistics, and end up with a well-trained nonlinear diffusion model specialized for Poisson denoising. The trained model provides strongly competitive results against state-of-the-art approaches, meanwhile bearing the properties of simple structure and high efficiency. Furthermore, our proposed model comes along with an additional advantage, that the diffusion process is well-suited for parallel computation on graphics processing units (GPUs). For images of size , our GPU implementation takes less than 0.1 s to produce state-of-the-art Poisson denoising performance.

Infrared fiber optic evanescent wave spectroscopy: applications in biology and medicine

NASA Astrophysics Data System (ADS)

Afanasyeva, Natalia I.; Bruch, Reinhard F.; Katzir, Abraham

1999-04-01

A new powerful and highly sensitive technique for non-invasive biomedical diagnostics in vivo has been developed using Infrared Fiberoptic Evanescent Wave Fourier Transform Spectroscopy (FEW-FTIR). This compact and portable method allows to detect functional chemical groups and bonds via vibrational spectroscopy directly from surfaces including living tissue. Such differences and similarities in molecular structure of tissue and materials can be evaluated online. Operating in the attenuated total reflection (ATR) regime in the middle-infrared (MIR) range, the FEW-FTIR technique provides direct contact between the fiber probe and tissue for non-destructive, non-invasive, fast and remote (few meters) diagnostics and quality control of materials. This method utilizes highly flexible and extremely low loss unclad fibers, for example silver halide fibers. Applications of this method include investigations of normal skin, precancerous and cancerous conditions, monitoring of the process of aging, allergic reactions and radiation damage to the skin. This setup is suitable as well for the detection of the influence of environmental factors (sun, water, pollution, and weather) on skin surfaces. The FEW-FTIR technique is very promising also for fast histological examinations in vitro. In this review, we present recent investigations of skin, breast, lung, stomach, kidney tissues in vivo and ex vivo (during surgery) to define the areas of tumor localization. The main advantages of the FEW-FTIR technique for biomedical, clinical, and environmental applications are discussed.

Catastrophic cooling and cessation of heating in the solar corona

NASA Astrophysics Data System (ADS)

Peter, H.; Bingert, S.; Kamio, S.

2012-01-01

Context. Condensations in the more than 106 K hot corona of the Sun are commonly observed in the extreme ultraviolet (EUV). While their contribution to the total solar EUV radiation is still a matter of debate, these condensations certainly provide a valuable tool for studying the dynamic response of the corona to the heating processes. Aims: We investigate different distributions of energy input in time and space to investigate which process is most relevant for understanding these coronal condensations. Methods: For a comparison to observations we synthesize EUV emission from a time-dependent, one-dimensional model for coronal loops, where we employ two heating scenarios: simply shutting down the heating and a model where the heating is very concentrated at the loop footpoints, while keeping the total heat input constant. Results: The heating off/on model does not lead to significant EUV count rates that one observes with SDO/AIA. In contrast, the concentration of the heating near the footpoints leads to thermal non-equilibrium near the loop top resulting in the well-known catastrophic cooling. This process gives a good match to observations of coronal condensations. Conclusions: This shows that the corona needs a steady supply of energy to support the coronal plasma, even during coronal condensations. Otherwise the corona would drain very fast, too fast to even form a condensation. Movies are available in electronic form at http://www.aanda.org

Dynamics of cell proliferation and apoptosis reflect different life strategies in hydrothermal vent and cold seep vestimentiferan tubeworms.

PubMed

Pflugfelder, Bettina; Cary, S Craig; Bright, Monika

2009-07-01

Deep-sea vestimentiferan tubeworms, which live in symbiosis with bacteria, exhibit different life strategies according to their habitat. At unstable and relatively short-lived hydrothermal vents, they grow extremely fast, whereas their close relatives at stable and long-persisting cold seeps grow slowly and live up to 300 years. Growth and age differences are thought to occur because of ecological and physiological adaptations. However, the underlying mechanisms of cell proliferation and death, which are closely linked to homeostasis, growth, and longevity, are unknown. Here, we show by immunohistochemical and ultrastructural cell cycle analyses that cell proliferation activities of the two species studied are higher than in any other characterized invertebrate, being only comparable with tumor and wound-healing processes. The slow growth in Lamellibrachia luymesi from cold seeps results from balanced activities of proliferation and apoptosis in the epidermis. In contrast, Riftia pachyptila from hydrothermal vents grows fast because apoptosis is down-regulated in this tissue. The symbiont-housing organ, the trophosome, exhibits a complex cell cycle and terminal differentiation pattern in both species, and growth is regulated by proliferation. These mechanisms have similarities to the up- and down-regulation of proliferation or apoptosis in various types of tumor, although they occur in healthy animals in this study, thus providing significant insights into the underlying mechanisms of growth and longevity.

BMDO materials testing in the EOIM-3 experiment

NASA Technical Reports Server (NTRS)

Chung, Shirley Y.; Brinza, David E.; Minton, Timothy K.; Liang, Ranty H.

1995-01-01

The NASA Evaluation of Oxygen Interactions with Materials-3 (EOIM-3) experiment served as a testbed for a variety of materials that are candidates for Ballistic Missile Defense Organization (BMDO) space assets. The materials evaluated on this flight experiment were provided by BMDO contractors and technology laboratories. A parallel ground-based exposure evaluation was conducted using the Fast Atom Sample Tester (FAST) atomic-oxygen simulation facility at Physical Sciences, Inc. The EOIM-3 flight materials were exposed to an atomic oxygen fluence of approximately 2.3 x 10(exp 20) atoms/sq cm. The ground-based exposure fluence of 2.0 - 2.5 x 10(exp 20) atoms/sq cm permits direct comparison with that of the flight-exposed specimens. The results from the flight test conducted aboard STS-46 and the correlative ground-based exposure are summarized here. A more detailed correlation study is presented in the JPL Publication 93-31 entitled 'Flight-and Ground-Test Correlation Study of BMDO SDS Materials: Phase 1 Report'. In general, the majority of the materials survived the AO environment with their performance tolerances maintained for the duration of the exposure. Optical materials, baffles, and coatings performed extremely well as did most of the thermal coatings and tribological materials. A few of the candidate radiator, threat shielding, and structural materials showed significant degradation. Many of the coatings designed to protect against AO erosion of sensitive materials performed this function well.

A DNA Barcode-Based RPA Assay (BAR-RPA) for Rapid Identification of the Dry Root of Ficus hirta (Wuzhimaotao).

PubMed

Tian, Enwei; Liu, Qianqian; Ye, Haoting; Li, Fang; Chao, Zhi

2017-12-18

Background: Wuzhimaotao (the dry root of Ficus hirta ) is used as both medicine and food ingredient by the locals in areas around Nanling Mountains of China. Due to its very similar external morphologies with Duanchangcao (the root of Gelsemium elegans , which contains gelsemine that is extremely neurotoxic) and the associated growth of these two plants, incidents of food poisoning and even death frequently occur, resulting from the misuse of Duanchangcao as Wuzhimaotao. The aim of this study is to develop a fast, even, on-spot approach to identification of Wuzhimaotao. Methods: We used DNA barcode-based recombinase polymerase amplification (BAR-RPA) with species-specific primers targeting the internal transcribed spacer (ITS) region of the rDNA of F. hirta. BAR-RPA reaction time and temperature were optimized and the specificity and sensitivity of BAR-RPA species-specific primers were assessed. Results: This technique showed a high specificity and sensitivity to amplify the genomic DNA of F. hirta and allowed for rapid amplification (within 15 min) of the ITS region under a constant and mild temperature range of 37-42 °C without using thermocyclers. Conclusions: The BAR-RPA assay with a fast DNA extraction protocol provides a simple, energy-saving, and rapid method for identification of Wuzhimaotao in both laboratory and field settings.

In situ polymerized superhydrophobic and superoleophilic nanofibrous membranes for gravity driven oil-water separation

NASA Astrophysics Data System (ADS)

Tang, Xiaomin; Si, Yang; Ge, Jianlong; Ding, Bin; Liu, Lifang; Zheng, Gang; Luo, Wenjing; Yu, Jianyong

2013-11-01

Creating an efficient, cost-effective method that can provide simple, practical and high-throughput separation of oil-water mixtures has proved extremely challenging. This work responds to these challenges by designing, fabricating and evaluating a novel fluorinated polybenzoxazine (F-PBZ) modified nanofibrous membrane optimized to achieve gravity driven oil-water separation. The membrane design is then realized by a facile combination of electrospun poly(m-phenylene isophthalamide) (PMIA) nanofibers and an in situ polymerized F-PBZ functional layer incorporating SiO2 nanoparticles (SiO2 NPs). By employing the F-PBZ/SiO2 NP modification, the pristine hydrophilic PMIA nanofibrous membranes are endowed with promising superhydrophobicity with a water contact angle of 161° and superoleophilicity with an oil contact angle of 0°. This new membrane shows high thermal stability (350 °C) and good repellency to hot water (80 °C), and achieves an excellent mechanical strength of 40.8 MPa. Furthermore, the as-prepared membranes exhibited fast and efficient separation of oil-water mixtures by a solely gravity driven process, which makes them good candidates for industrial oil-polluted water treatments and oil spill cleanup, and also provided new insights into the design and development of functional nanofibrous membranes through F-PBZ modification.Creating an efficient, cost-effective method that can provide simple, practical and high-throughput separation of oil-water mixtures has proved extremely challenging. This work responds to these challenges by designing, fabricating and evaluating a novel fluorinated polybenzoxazine (F-PBZ) modified nanofibrous membrane optimized to achieve gravity driven oil-water separation. The membrane design is then realized by a facile combination of electrospun poly(m-phenylene isophthalamide) (PMIA) nanofibers and an in situ polymerized F-PBZ functional layer incorporating SiO2 nanoparticles (SiO2 NPs). By employing the F-PBZ/SiO2 NP modification, the pristine hydrophilic PMIA nanofibrous membranes are endowed with promising superhydrophobicity with a water contact angle of 161° and superoleophilicity with an oil contact angle of 0°. This new membrane shows high thermal stability (350 °C) and good repellency to hot water (80 °C), and achieves an excellent mechanical strength of 40.8 MPa. Furthermore, the as-prepared membranes exhibited fast and efficient separation of oil-water mixtures by a solely gravity driven process, which makes them good candidates for industrial oil-polluted water treatments and oil spill cleanup, and also provided new insights into the design and development of functional nanofibrous membranes through F-PBZ modification. Electronic supplementary information (ESI) available: Detailed synthesis and structural confirmation of BAF-oda, OCA results, Raman spectrum and Movies S1 and S2. See DOI: 10.1039/c3nr03937d

Single image super-resolution via regularized extreme learning regression for imagery from microgrid polarimeters

NASA Astrophysics Data System (ADS)

Sargent, Garrett C.; Ratliff, Bradley M.; Asari, Vijayan K.

2017-08-01

The advantage of division of focal plane imaging polarimeters is their ability to obtain temporally synchronized intensity measurements across a scene; however, they sacrifice spatial resolution in doing so due to their spatially modulated arrangement of the pixel-to-pixel polarizers and often result in aliased imagery. Here, we propose a super-resolution method based upon two previously trained extreme learning machines (ELM) that attempt to recover missing high frequency and low frequency content beyond the spatial resolution of the sensor. This method yields a computationally fast and simple way of recovering lost high and low frequency content from demosaicing raw microgrid polarimetric imagery. The proposed method outperforms other state-of-the-art single-image super-resolution algorithms in terms of structural similarity and peak signal-to-noise ratio.

An assessment of the hardness of miniature vacuum tubes to high-voltage transients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orvis, W.J.

1990-03-01

Miniature vacuum tubes are vacuum switching and control devices fabricated on a silicon wafer, using the same technology as is used to make integrated circuits. They operate in much the same manner as conventional vacuum tubes, but with two important differences: they are micron sized devices, and they employ field emission instead of thermionic emission as the electron source. As these devices have a vacuum as their active region, they will be extremely hard to nuclear radiation and relatively insensitive to temperature effects, they are also expected to be extremely fast devices. We have estimated here that their hardness tomore » high-voltage transients will be at least as good as existing semiconductor devices and possibly better. 5 figs.« less

The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kippen, Karen Elizabeth; Montoya, Donald Raymond

The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) andmore » its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.« less

Fast Scanning Calorimetry Studies of Supercooled Liquids and Glasses

NASA Astrophysics Data System (ADS)

Bhattacharya, Deepanjan

This dissertation is a compilation of research results of extensive Fast Scanning Calorimetry studies of two non-crystalline materials: Toluene and Water. Motivation for fundamental studies of non-crystalline phases, a brief overview of glassy materials and concepts and definitions related to them is provided in Chapter 1. Chapter 2 provides fundamentals and details of experimental apparata, experimental protocol and calibration procedure. Chapter 3 & 4 provides extensive studies of stable non-crystalline toluene films of micrometer and nanometer thicknesses grown by vapor deposition at distinct deposition rates and temperatures and probed by Fast Scanning Calorimetry. Fast scanning calorimetry is shown to be extremely sensitive to the structure of the vapor-deposited phase and was used to characterize simultaneously its kinetic stability and its thermodynamic properties. According to our analysis, transformation of vapor -deposited samples of toluene during heating with rates in excess 100,000 K/s follows the zero-order kinetics. The transformation rate correlates strongly with the initial enthalpy of the sample, which increases with the deposition rate according to sub-linear law. Analysis of the transformation kinetics of vapor deposited toluene films of various thicknesses reveal a sudden increase in the transformation rate for films thinner than 250 nm. The change in kinetics correlates with the surface roughness scale of the substrate, which is interpreted as evidence for kinetic anisotropy of the samples. We also show that out-of-equilibrium relaxation kinetics and possibly the enthalpy of vapor-deposited (VD) films of toluene are distinct from those of ordinary supercooled (OS) phase even when the deposition takes place at temperatures above the glass softening (Tg). The implications of these findings for the formation mechanism and structure of vapor deposited stable glasses are discussed. Chapter 5 and 6 provide detailed Fast Scanning Calorimetry studies of amorphous solid water in bulk and confining geometry (ultrathin films and nano-aggregates). Bulk-like water samples were prepared by vapor-deposition on the surface of a tungsten filament near 140 K where vapor-deposition results in low enthalpy glassy water films. The vapor deposition approach was also used to grow nano-aggregates (2- 20 nm thick) and multiple ultrathin (approximately 50 nm thick) water films alternated with benzene and methanoic films of similar dimensions. When heated from cryogenic temperatures, the ultrathin water films underwent a well manifested glass softening transition at temperatures 20 degrees below the onset of crystallization. The thermograms of nano-aggregates of ASW films show two endotherms at 40 and 10 K below the onset temperatures of crystallization. However, no such transition was observed in bulk-like water samples prior to their crystallization. These results indicate that water in confined geometry demonstrates glass softening dynamics which are dramatically distinct from those of the bulk phase. We attribute these differences to water's interfacial glass transition which occurs at temperatures tens of degrees lower than that in the bulk. Implications of these finding for past studies of glass softening dynamics in various glassy water samples are discussed in chapter 5 and 6.

ASYMPTOTICS FOR CHANGE-POINT MODELS UNDER VARYING DEGREES OF MIS-SPECIFICATION

PubMed Central

SONG, RUI; BANERJEE, MOULINATH; KOSOROK, MICHAEL R.

2015-01-01

Change-point models are widely used by statisticians to model drastic changes in the pattern of observed data. Least squares/maximum likelihood based estimation of change-points leads to curious asymptotic phenomena. When the change–point model is correctly specified, such estimates generally converge at a fast rate (n) and are asymptotically described by minimizers of a jump process. Under complete mis-specification by a smooth curve, i.e. when a change–point model is fitted to data described by a smooth curve, the rate of convergence slows down to n1/3 and the limit distribution changes to that of the minimizer of a continuous Gaussian process. In this paper we provide a bridge between these two extreme scenarios by studying the limit behavior of change–point estimates under varying degrees of model mis-specification by smooth curves, which can be viewed as local alternatives. We find that the limiting regime depends on how quickly the alternatives approach a change–point model. We unravel a family of ‘intermediate’ limits that can transition, at least qualitatively, to the limits in the two extreme scenarios. The theoretical results are illustrated via a set of carefully designed simulations. We also demonstrate how inference for the change-point parameter can be performed in absence of knowledge of the underlying scenario by resorting to subsampling techniques that involve estimation of the convergence rate. PMID:26681814

Mechanically assisted liquid lens zoom system for mobile phone cameras

NASA Astrophysics Data System (ADS)

Wippermann, F. C.; Schreiber, P.; Bräuer, A.; Berge, B.

2006-08-01

Camera systems with small form factor are an integral part of today's mobile phones which recently feature auto focus functionality. Ready to market solutions without moving parts have been developed by using the electrowetting technology. Besides virtually no deterioration, easy control electronics and simple and therefore cost-effective fabrication, this type of liquid lenses enables extremely fast settling times compared to mechanical approaches. As a next evolutionary step mobile phone cameras will be equipped with zoom functionality. We present first order considerations for the optical design of a miniaturized zoom system based on liquid-lenses and compare it to its mechanical counterpart. We propose a design of a zoom lens with a zoom factor of 2.5 considering state-of-the-art commercially available liquid lens products. The lens possesses auto focus capability and is based on liquid lenses and one additional mechanical actuator. The combination of liquid lenses and a single mechanical actuator enables extremely short settling times of about 20ms for the auto focus and a simplified mechanical system design leading to lower production cost and longer life time. The camera system has a mechanical outline of 24mm in length and 8mm in diameter. The lens with f/# 3.5 provides market relevant optical performance and is designed for an image circle of 6.25mm (1/2.8" format sensor).

Relativistic MHD modeling of magnetized neutron stars, pulsar winds, and their nebulae

NASA Astrophysics Data System (ADS)

Del Zanna, L.; Pili, A. G.; Olmi, B.; Bucciantini, N.; Amato, E.

2018-01-01

Neutron stars are among the most fascinating astrophysical sources, being characterized by strong gravity, densities about the nuclear one or even above, and huge magnetic fields. Their observational signatures can be extremely diverse across the electromagnetic spectrum, ranging from the periodic and low-frequency signals of radio pulsars, up to the abrupt high-energy gamma-ray flares of magnetars, where energies of ∼ {10}46 {erg} are released in a few seconds. Fast-rotating and highly magnetized neutron stars are expected to launch powerful relativistic winds, whose interaction with the supernova remnants gives rise to the non-thermal emission of pulsar wind nebulae, which are known cosmic accelerators of electrons and positrons up to PeV energies. In the extreme cases of proto-magnetars (magnetic fields of ∼ {10}15 G and millisecond periods), a similar mechanism is likely to provide a viable engine for the still mysterious gamma-ray bursts. The key ingredient in all these spectacular manifestations of neutron stars is the presence of strong magnetic fields in their constituent plasma. Here we will present recent updates of a couple of state-of-the-art numerical investigations by the high-energy astrophysics group in Arcetri: a comprehensive modeling of the steady-state axisymmetric structure of rotating magnetized neutron stars in general relativity, and dynamical 3D MHD simulations of relativistic pulsar winds and their associated nebulae.

Conceptual frameworks, geomorphic interpretation and storytelling: Tales from Lockyer Creek , Australia.

NASA Astrophysics Data System (ADS)

Croke, Jacky; Phillips, Jonathan; Van Dyke, Chris

2017-04-01

Earth science knowledge and insight begins with case studies, and theories should be derived from and ultimately evaluated against empirical, case study evidence. However, isolated case studies not linked conceptually to other locations or embedded within a broader framework are often of limited use beyond the study site. Geomorphic evidence and phenomena may be interpreted using a variety of conceptual frameworks (theories, models, laws, methodologies, etc.). The evidence may be, or at least appear to be, consistent with multiple frameworks, even when those constructs are derived from entirely different assumptions or frames of reference. Thus different interpretations and stories can be derived from the same evidence. Our purpose here is to illustrate this phenomenon via a case study from Lockyer Creek, southeast Queensland, Australia. Lockyer Creek is fast becoming one of Australia's most studied catchments with a wealth of data emerging following two extreme flood events in 2011 and 2013. Whilst the initial objective of the Big Flood project was to provide information on the frequency and magnitude of these extreme events, in essence the project revealed a rich 'story' of river evolution and adjustment which at first glance did not appear to 'fit' many established conceptual frameworks and theories. This presentation tells the tale of Lockyer Creek as it relates to selected key conceptual frameworks and importantly how this information can then be used for more effective catchment and flood management.

Individual Differences and Short-Term Military Factors Associated With Unhealthy Weight Control Behaviors Among Active Duty and Reserve Army Soldiers

DTIC Science & Technology

2009-03-01

syndrome eating disorders (Eisenberg & Neumark-Sztainer, 2008; Neumark-Sztainer et al., 2002; Rukavina & Pokrajac-Bulian, 2006). Although the...risk for developing full- syndrome eating disorders. Repeated periods of extreme weight loss behavior may reinforce that purging, fasting, or excessive...exercise are “good” ways to lose weight. In fact, many individuals with full syndrome eating disorders start by engaging in repeated periods of

Evaluation of the Human/Extreme Environment Interaction: Implications for Enhancing Operational Performance and Recovery

DTIC Science & Technology

2011-10-01

healthy conditions such as exercise (6) and weight loss (22,48) while fission (degradation, dysfunction) is associated with obesity and disease (3,4...before each trial. Following an overnight 12 hour fast , participants arrived at the laboratory in the early morning to complete testing. Upon...type 2 diabetes, obesity , weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes 54: 2685-2693, 2005. 4

Disseminated tuberculous myositis in a child with acute myelogenous leukemia.

PubMed

Chen, Yu-Chieh; Sheen, Jiunn-Ming; Huang, Li-Tung; Wu, Kuan-Sheng; Hsiao, Chih-Cheng

2009-04-01

Tuberculous myositis is extremely rare, even in immunocompromised hosts. We present a case of disseminated tuberculous myositis in a girl with secondary acute myelogenous Leukemia following successful chemotherapy for undifferentiated sarcoma of the maxillary sinus. The diagnosis was established by direct visualization of acid-fast bacilli in the biopsied nodule and by typical pathologic findings. Three weeks after initiation of antituberculosis treatment, the patient experienced both clinical and radiologic improvement.

From the Sun with Love

NASA Image and Video Library

2017-12-08

This Solar Dynamics Observatory image of the Sun taken on February 1, 2013 in extreme ultraviolet light captures a heart-shaped dark coronal hole. Coronal holes are areas of the Sun's surface that are the source of open magnetic field lines that head way out into space. They are also the source regions of the fast solar wind, which is characterized by a relatively steady speed of approximately 800 km/s (about 1.8 million mph).

Missileer: The Dawn, Decline, and Reinvigoration of America’s Intercontinental Ballistic Missile Operators

DTIC Science & Technology

2017-06-01

Group, resulting in all missiles entering ‘ radio mode’ and making them air-launch accessible.1 This loss of communications was an anomaly caused by an...MEECN) Program (MMP) Part of MEECN program that replaced legacy Survivable Low Frequency Communications System (SLFCS) with integrated extremely high...very low/low frequency (EHF/VLF/LF) communications capability. Began in 2003 and finished in 2005. Security Modernization (Three phases: Fast

National Defense Center of Excellence for Industrial Metrology and 3D Imaging

DTIC Science & Technology

2012-10-18

validation rather than mundane data-reduction/analysis tasks. Indeed, the new financial and technical resources being brought to bear by integrating CT...of extremely fast axial scanners. By replacing the single-spot detector by a detector array, a three-dimensional image is acquired by one depth scan...the number of acquired voxels per complete two-dimensional or three-dimensional image, the axial and lateral resolution, the depth range, the

Weather in the Cockpit: Priorities, Sources, Delivery, and Needs in the Next Generation Air Transportation System

DTIC Science & Technology

2012-07-01

discomfort. Extreme turbulence could cause physical injuries to pilot/ passengers who are not wearing seat belts. Clear Air Turbulence (CAT) CAT... passengers who are not wearing seat belts. Generally caused by wind shear in the atmosphere where no clouds are present. Mountain Waves Fast...ways in which our analyses could inform the design of information systems. NextGen, in its mature state, envisions pilots having control over

Inserting Agility in System Development

DTIC Science & Technology

2012-07-01

Agile IT Acquisition, IT Box, Scrum Inserting Agility in System Development Matthew R. Kennedy and Lt Col Dan Ward, USAF With the fast-paced nature...1,700 individuals and 71 countries, found Scrum and eXtreme Programming to be the most widely followed method- ologies (VersionOne, 2007). Other...University http://www.dau.mil 259 Defense ARJ, July 2012, Vol. 19 No. 3 : 249–264 Scrum Scrum is a framework used for project management, which is

Robust 1-Bit Compressive Sensing via Binary Stable Embeddings of Sparse Vectors

DTIC Science & Technology

2011-04-15

funded by Mitsubishi Electric Research Laboratories. †ICTEAM Institute, ELEN Department, Université catholique de Louvain (UCL), B-1348 Louvain-la-Neuve...reduced to a simple comparator that tests for values above or below zero, enabling extremely simple, efficient, and fast quantization. A 1-bit quantizer is...these two terms appears to be significantly different, according to the previously discussed experiments. To test the hypothesis that this term is the key

Variability in the reported energy, total fat and saturated fat contents in fast-food products across ten countries.

PubMed

Ziauddeen, Nida; Fitt, Emily; Edney, Louise; Dunford, Elizabeth; Neal, Bruce; Jebb, Susan A

2015-11-01

Fast foods are often energy dense and offered in large serving sizes. Observational data have linked the consumption of fast foods to an increased risk of obesity and related diseases. We surveyed the reported energy, total fat and saturated fat contents, and serving sizes, of fast-food items from five major chains across ten countries, comparing product categories as well as specific food items available in most countries. MRC Human Nutrition Research, Cambridge, UK. Data for 2961 food and drink products were collected, with most from Canada (n 550) and fewest from the United Arab Emirates (n 106). There was considerable variability in energy and fat contents of fast foods across countries, reflecting both the portfolio of products and serving size variability. Differences in total energy between countries were particularly noted for chicken dishes (649-1197 kJ/100 g) and sandwiches (552-1050 kJ/100g). When comparing the same product between countries variations were consistently observed in total energy and fat contents (g/100 g); for example, extreme variation in McDonald's Chicken McNuggets with 12 g total fat/100 g in Germany compared with 21·1 g/100 g in New Zealand. These cross-country variations highlight the possibility for further product reformulation in many countries to reduce nutrients of concern and improve the nutritional profiles of fast-food products around the world. Standardisation of serving sizes towards the lower end of the range would also help to reduce the risk of overconsumption.

Variability in the reported energy, total fat and saturated fat content in fast food products across ten countries

PubMed Central

Ziauddeen, Nida; Fitt, Emily; Edney, Louise; Dunford, Elizabeth; Neal, Bruce; Jebb, Susan A.

2016-01-01

Objective Fast foods are often energy dense and offered in large serving sizes. Observational data has linked the consumption of fast food to an increased risk of obesity and related diseases. Design We surveyed the reported energy, total fat and saturated fat contents, and serving sizes, of fast food items from five major chains across 10 countries, comparing product categories as well as specific food items available in most countries. Setting MRC Human Nutrition Research (HNR), Cambridge Subjects Data for 2961 food and drink products were collected, with most from Canada (n=550) and fewest from United Arab Emirates (n=106). Results There was considerable variability in energy and fat content of fast food across countries, reflecting both the portfolio of products, and serving size variability. Differences in total energy between countries were particularly noted for chicken dishes (649-1197kJ/100g) and sandwiches (552-1050kJ/100g). When comparing the same product between countries variations were consistently observed in total energy and fat content (g/100g) with extreme variation in McDonald’s Chicken McNuggets with 12g total fat (g/100g) in Germany compared to 21.1g in New Zealand. Conclusions These cross-country variations highlight the possibility for further product reformulation in many countries to reduce nutrients of concern and improve the nutritional profiles of fast food products around the world. Standardisation of serving sizes towards the lower end of the range would also help to reduce the risk of overconsumption. PMID:25702788

Developing a Framework for Seamless Prediction of Sub-Seasonal to Seasonal Extreme Precipitation Events in the United States.

NASA Astrophysics Data System (ADS)

Rosendahl, D. H.; Ćwik, P.; Martin, E. R.; Basara, J. B.; Brooks, H. E.; Furtado, J. C.; Homeyer, C. R.; Lazrus, H.; Mcpherson, R. A.; Mullens, E.; Richman, M. B.; Robinson-Cook, A.

2017-12-01

Extreme precipitation events cause significant damage to homes, businesses, infrastructure, and agriculture, as well as many injures and fatalities as a result of fast-moving water or waterborne diseases. In the USA, these natural hazard events claimed the lives of more than 300 people during 2015 - 2016 alone, with total damage reaching $24.4 billion. Prior studies of extreme precipitation events have focused on the sub-daily to sub-weekly timeframes. However, many decisions for planning, preparing and resilience-building require sub-seasonal to seasonal timeframes (S2S; 14 to 90 days), but adequate forecasting tools for prediction do not exist. Therefore, the goal of this newly funded project is an enhancement in understanding of the large-scale forcing and dynamics of S2S extreme precipitation events in the United States, and improved capability for modeling and predicting such events. Here, we describe the project goals, objectives, and research activities that will take place over the next 5 years. In this project, a unique team of scientists and stakeholders will identify and understand weather and climate processes connected with the prediction of S2S extreme precipitation events by answering these research questions: 1) What are the synoptic patterns associated with, and characteristic of, S2S extreme precipitation evens in the contiguous U.S.? 2) What role, if any, do large-scale modes of climate variability play in modulating these events? 3) How predictable are S2S extreme precipitation events across temporal scales? 4) How do we create an informative prediction of S2S extreme precipitation events for policymaking and planing? This project will use observational data, high-resolution radar composites, dynamical climate models and workshops that engage stakeholders (water resource managers, emergency managers and tribal environmental professionals) in co-production of knowledge. The overarching result of this project will be predictive models to reduce of the societal and economic impacts of extreme precipitation events. Another outcome will include statistical and co-production frameworks, which could be applied across other meteorological extremes, all time scales and in other parts of the world to increase resilience to extreme meteorological events.

Secure FAST: Security Enhancement in the NATO Time Sensitive Targeting Tool

DTIC Science & Technology

2010-11-01

designed to aid in the tracking and prosecuting of Time Sensitive Targets. The FAST tool provides user level authentication and authorisation in terms...level authentication and authorisation in terms of security. It uses operating system level security but does not provide application level security for...and collaboration tool, designed to aid in the tracking and prosecuting of Time Sensitive Targets. The FAST tool provides user level authentication and

[Diabetes and fasting during Ramadan. A observational study among Turkish immigrants in Belgium].

PubMed

Peeters, B; Mehuys, E; Van Tongelen, I; Van Bever, E; Bultereys, L; Avonts, D; Yildiz, G; Remon, J P; Boussery, K

2013-03-01

To investigate (i) Ramadan participation, (ii) provision of Ramadan related advice by healthcare providers (iii) medication use during Ramadan fasting among Turkish migrants with diabetes in Belgium. This pilot observational study was conducted among a convenience sample of 52 Turkish migrants with diabetes in Belgium. Two questionnaires collected information on socio-demographic characteristics, diabetes related characteristics, current hypoglycaemic medication with dosing regimen, participation in the past Ramadan, reasons for (non)participation, use of hypoglycaemic medication during the past Ramadan, advice from their healthcare providers about fasting during Ramadan and follow up of this advice. Sixteen patients (31%) had fasted during the past Ramadan. Main reason for Ramadan participation was reinforcement of faith (12/15), while the main reason for non participation was having diabetes (34/36). About 56% of the study population had received recommendations from their healthcare provider(s) about fasting and diabetes during Ramadan. The most commonly provided advice was not to participate in Ramadan, followed by modification of drug therapy. Only 3 patients ignored the advice of their healthcare professionals. In addition, only 60% of those who actually fasted received recommendations about intake of diabetes medication during the ramadan. Most fasters continued their medication dose unchanged (87% of OHA users and 80% of the insulin users). This pilot study found a low prevalence of Ramadan fasting among Turkish migrants with diabetes in Belgium. We also found that provision of advice by healthcare providers could be improved. Larger scale studies are warranted to confirm these findings.

Fast pitch softball injuries.

PubMed

Meyers, M C; Brown, B R; Bloom, J A

2001-01-01

The popularity of fast pitch softball in the US and throughout the world is well documented. Along with this popularity, there has been a concomitant increase in the number of injuries. Nearly 52% of cases qualify as major disabling injuries requiring 3 weeks or more of treatment and 2% require surgery. Interestingly, 75% of injuries occur during away games and approximately 31% of traumas occur during nonpositional and conditioning drills. Injuries range from contusions and tendinitis to ligamentous disorders and fractures. Although head and neck traumas account for 4 to 12% of cases, upper extremity traumas account for 23 to 47% of all injuries and up to 19% of cases involve the knee. Approximately 34 to 42% of injuries occur when the athlete collides with another individual or object. Other factors involved include the quality of playing surface, athlete's age and experience level, and the excessive physical demands associated with the sport. Nearly 24% of injuries involve base running and are due to poor judgement, sliding technique, current stationary base design, unorthodox joint and extremity position during ground impact and catching of cleats. The increasing prevalence of overtraining syndrome among athletes has been attributed to an unclear definition of an optimal training zone, poor communication between player and coach, and the limited ability of bone and connective tissue to quickly respond to match the demands of the sport. This has led routinely to arm, shoulder and lumbar instability, chronic nonsteroidal anti-inflammatory drug (NSAID) use and time loss injuries in 45% of pitching staff during a single season. Specific attention to a safer playing environment, coaching and player education, and sport-specific training and conditioning would reduce the risk, rate and severity of fast pitch traumas. Padding of walls, backstops, rails and dugout areas, as well as minimising use of indoor facilities, is suggested to decrease the number of collision injuries. Coaches should be cognisant of overtraining, vary day-to-day training routines to decrease repetitive musculoskeletal stress, focus on motor skills with equal emphasis on speed and efficiency of movement, and use drills that reinforce sport-specific, decision making processes to minimise mental mistakes. Conditioning programs that emphasise a combination of power, acceleration, flexibility, technical skill, functional capacity and injury prevention are recommended. Due to the limited body of knowledge presently available on this sport, a greater focus on injury surveillance would provide a clearer picture of injury causation and effective management procedures, leading toward safer participation and successful player development.

Hydrogen Financial Analysis Scenario Tool (H2FAST); NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melaina, Marc

This presentation describes the Hydrogen Financial Analysis Scenario Tool, H2FAST, and provides an overview of each of the three H2FAST formats: the H2FAST web tool, the H2FAST Excel spreadsheet, and the H2FAST Business Case Scenario (BCS) tool. Examples are presented to illustrate the types of questions that H2FAST can help answer.

Changes in the probability of co-occurring extreme climate events

NASA Astrophysics Data System (ADS)

Diffenbaugh, N. S.

2017-12-01

Extreme climate events such as floods, droughts, heatwaves, and severe storms exert acute stresses on natural and human systems. When multiple extreme events co-occur, either in space or time, the impacts can be substantially compounded. A diverse set of human interests - including supply chains, agricultural commodities markets, reinsurance, and deployment of humanitarian aid - have historically relied on the rarity of extreme events to provide a geographic hedge against the compounded impacts of co-occuring extremes. However, changes in the frequency of extreme events in recent decades imply that the probability of co-occuring extremes is also changing, and is likely to continue to change in the future in response to additional global warming. This presentation will review the evidence for historical changes in extreme climate events and the response of extreme events to continued global warming, and will provide some perspective on methods for quantifying changes in the probability of co-occurring extremes in the past and future.

Inexpensive and fast pathogenic bacteria screening using field-effect transistors.

PubMed

Formisano, Nello; Bhalla, Nikhil; Heeran, Mel; Reyes Martinez, Juana; Sarkar, Amrita; Laabei, Maisem; Jolly, Pawan; Bowen, Chris R; Taylor, John T; Flitsch, Sabine; Estrela, Pedro

2016-11-15

While pathogenic bacteria contribute to a large number of globally important diseases and infections, current clinical diagnosis is based on processes that often involve culturing which can be time-consuming. Therefore, innovative, simple, rapid and low-cost solutions to effectively reduce the burden of bacterial infections are urgently needed. Here we demonstrate a label-free sensor for fast bacterial detection based on metal-oxide-semiconductor field-effect transistors (MOSFETs). The electric charge of bacteria binding to the glycosylated gates of a MOSFET enables quantification in a straightforward manner. We show that the limit of quantitation is 1.9×10(5) CFU/mL with this simple device, which is more than 10,000-times lower than is achieved with electrochemical impedance spectroscopy (EIS) and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-ToF) on the same modified surfaces. Moreover, the measurements are extremely fast and the sensor can be mass produced at trivial cost as a tool for initial screening of pathogens. Copyright © 2016 Elsevier B.V. All rights reserved.

Completed Ulnar Shaft Stress Fracture in a Fast-Pitch Softball Pitcher.

PubMed

Wiltfong, Roger E; Carruthers, Katherine H; Popp, James E

2017-03-01

Stress fractures of the upper extremity have been previously described in the literature, yet reports of isolated injury to the ulna diaphysis or olecranon are rare. The authors describe a case involving an 18-year-old fast-pitch softball pitcher. She presented with a long history of elbow and forearm pain, which was exacerbated during a long weekend of pitching. Her initial physician diagnosed her as having forearm tendinitis. She was treated with nonsurgical means including rest, anti-inflammatory medications, therapy, and kinesiology taping. She resumed pitching when allowed and subsequently had an acute event immediately ceasing pitching. She presented to an urgent care clinic that evening and was diagnosed as having a complete ulnar shaft fracture subsequently needing surgical management. This case illustrates the need for a high degree of suspicion for ulnar stress fractures in fast-pitch soft-ball pitchers with an insidious onset of unilateral forearm pain. Through early identification and intervention, physicians may be able to reduce the risk of injury progression and possibly eliminate the need for surgical management. [Orthopedics. 2017; 40(2):e360-e362.]. Copyright 2016, SLACK Incorporated.

Towards denoising XMCD movies of fast magnetization dynamics using extended Kalman filter.

PubMed

Kopp, M; Harmeling, S; Schütz, G; Schölkopf, B; Fähnle, M

2015-01-01

The Kalman filter is a well-established approach to get information on the time-dependent state of a system from noisy observations. It was developed in the context of the Apollo project to see the deviation of the true trajectory of a rocket from the desired trajectory. Afterwards it was applied to many different systems with small numbers of components of the respective state vector (typically about 10). In all cases the equation of motion for the state vector was known exactly. The fast dissipative magnetization dynamics is often investigated by x-ray magnetic circular dichroism movies (XMCD movies), which are often very noisy. In this situation the number of components of the state vector is extremely large (about 10(5)), and the equation of motion for the dissipative magnetization dynamics (especially the values of the material parameters of this equation) is not well known. In the present paper it is shown by theoretical considerations that - nevertheless - there is no principle problem for the use of the Kalman filter to denoise XMCD movies of fast dissipative magnetization dynamics. Copyright © 2014 Elsevier B.V. All rights reserved.

WindPACT Reference Wind Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dykes, Katherine L; Rinker, Jennifer

To fully understand how loads and turbine cost scale with turbine size, it is necessary to have identical turbine models that have been scaled to different rated powers. The report presents the WindPACT baseline models, which are a series of four baseline models that were designed to facilitate investigations into the scalings of loads and turbine cost with size. The models have four different rated powers (750 kW, 1.5 MW, 3.0 MW, and 5.0 MW), and each model was designed to its specified rated power using the same design methodology. The models were originally implemented in FAST_AD, the predecessor tomore » NREL's open-source wind turbine simulator FAST, but have yet to be implemented in FAST. This report contains the specifications for all four WindPACT baseline models - including structural, aerodynamic, and control specifications - along with the inherent assumptions and equations that were used to calculate the model parameters. It is hoped that these baseline models will serve as extremely useful resources for investigations into the scalings of costs, loads, or optimization routines.« less

Dewatering and granulation of sewage sludge by biophysical drying and thermo-degradation performance of prepared sludge particles during succedent fast pyrolysis.

PubMed

Han, Rong; Liu, Jinwen; Zhang, Yuancheng; Fan, Xiaoqian; Lu, Wenjing; Wang, Hongtao

2012-03-01

A novel two-step technology, fast biophysical drying (BPD) coupling with fast pyrolysis (FP), was investigated for moisture removal and energy recovery from sewage sludge. For BPD, combined operations of extreme thermophilic amendment (with accelerated increasing and controllable maintenance of substrate temperature) and enhanced convective evaporation were conducted, both beneficial for moisture removal (moisture content reaching 23.1% for 7d) and organic preservation. Biophysical-dried sludge (BPDS) was characterized by homogeneous fine-particle morphology and well-developed porous microstructure. The synthesized BPDS particle preserved most organic components (92% volatile matters and 79% HHV of traditional thermal-dried sludge [TTDS]) attributable to the inhibitory effect of BPD adjustment, presenting considerable capacity for subsequent residue-derived energy. For FP, the distribution of products from BPDS pyrolysis indicated that syngas and char yields were higher than those of TTDS. The syngas from BPDS is a type of hydrogen-rich gas composed of 42.6 vol.% H(2) at 900°C. Copyright © 2011 Elsevier Ltd. All rights reserved.

A Repeating Fast Radio Burst: Radio and X-ray Follow-up Observations of FRB 121102

NASA Astrophysics Data System (ADS)

Scholz, Paul; Spitler, Laura; Hessels, Jason; Bogdanov, Slavko; Brazier, Adam; Camilo, Fernando; Chatterjee, Shami; Cordes, James M.; Crawford, Fronefield; Deneva, Julia S.; Ferdman, Robert; Freire, Paulo; Kaspi, Victoria M.; Lazarus, Patrick; Lynch, Ryan; Madsen, Erik; McLaughlin, Maura; Patel, Chitrang; Ransom, Scott M.; Seymour, Andrew; Stairs, Ingrid H.; Stappers, Benjamin; van Leeuwen, Joeri; Zhu, Weiwei

2016-04-01

A new phenomenon has emerged in high-energy astronomy in the past few years: the Fast Radio Burst. Fast Radio Bursts (FRBs) are millisecond-duration radio bursts whose dispersion measures imply that they originate from far outside of the Galaxy. Their origin is as yet unknown; their durations and energetics imply that they involve compact objects, such as neutron stars or black holes. Due to their extreme luminosities implied by their distances and the previous absence of any repeat burst in follow-up observations, many potential explanations involve one-time cataclysmic events. However, in our Arecibo telescope follow-up observations of FRB 121102 (discovered in the PALFA survey; Spitler et al. 2014), we find additional bursts at the same location and dispersion measure as the original burst. We also present the results of Swift and Chandra X-ray observations of the field. This result shows that, for at least a sub-set of the FRB population, the source can repeat and thus cannot be explained by a cataclysmic origin.

The risk of shorter fasting time for pediatric deep sedation.

PubMed

Clark, Mathew; Birisci, Esma; Anderson, Jordan E; Anliker, Christina M; Bryant, Micheal A; Downs, Craig; Dalabih, Abdallah

2016-01-01

Current guidelines adopted by the American Academy of Pediatrics calls for prolonged fasting times before performing pediatric procedural sedation and analgesia (PSA). PSA is increasingly provided to children outside of the operating theater by sedation trained pediatric providers and does not require airway manipulation. We investigated the safety of a shorter fasting time compared to a longer and guideline compliant fasting time. We tried to identify the association between fasting time and sedation-related complications. This is a prospective observational study that included children 2 months to 18 years of age and had an American Society of Anesthesiologists physical status classification of I or II, who underwent deep sedation for elective procedures, performed by pediatric critical care providers. Procedures included radiologic imaging studies, electroencephalograms, auditory brainstem response, echocardiograms, Botox injections, and other minor surgical procedures. Subjects were divided into two groups depending on the length of their fasting time (4-6 h and >6 h). Complication rates were calculated and compared between the three groups. In the studied group of 2487 subjects, 1007 (40.5%) had fasting time of 4-6 h and the remaining 1480 (59.5%) subjects had fasted for >6 h. There were no statistically significant differences in any of the studied complications between the two groups. This study found no difference in complication rate in regard to the fasting time among our subjects cohort, which included only healthy children receiving elective procedures performed by sedation trained pediatric critical care providers. This suggests that using shorter fasting time may be safe for procedures performed outside of the operating theater that does not involve high-risk patients or airway manipulation.

Assessing and modeling sediment mobility in estuarine and coastal settings due to extreme climate events from natural short-lived isotope distribution

NASA Astrophysics Data System (ADS)

Ghaleb, Bassam; Hillaire-Marcel, Claude; Ruiz Fernandez, Ana-Carolina; Sanchez Cabeza, Joan-Albert

2016-04-01

Climatic events (e.g. floods, storminess) and management activities (e.g. dredging) may result in the burial or removal and re-suspension of sediments in estuaries and coastal areas. When such sediments are contaminated, such processes may either help restoring better chemical environments or lead to their long-term contamination. Geochemical signatures in surface sediments may help identifying such sedimentological events. However, short-lived isotope data are generally required to set time-constraints on their occurrence. Whereas 210Pb and radioactive fallout isotope contents can help setting time constraints at ~50 to ~100 yr-time scales, natural disequilibria in the 232Th-228Ra-228Th sequence do provide information on processes which occurred within the last 30 yrs, as illustrated in the present study. Box-cored sediments from the Saguenay Fjord and lower estuary of the St. Lawrence (Canada) as well as from estuaries and lagoons from the Sinaloa Coast (Mexico) are used to document the behavior of these isotopes either under relatively steady conditions (St. Lawrence estuary) or under high-frequency extreme climate events (storms and floods; Saguenay Fjord, Coastal Sinaloa). 228Th/232Th activity ratios were determined by chemical extraction of Th and alpha counting of unspiked samples, rapidly after sampling (228Th/232Th). The activity of the intermediate isotope 228Ra was then estimated based on replicate measurements on aliquot samples made a few years later. Under steady conditions, core-top sediment shows an excess in 228Th vs 232Th (AR ~ 1.6), whereas the intermediate 228Ra depicts a deficit vs its parent 232Th (AR ~0.6). Downcore, radioactive decay carries rapidly 228Th-activities to those of the parent 228Ra within about 10 yrs (i.e., ~ 5 half-lives of 228Th), then both move during the next ~20 yrs (~ i.e., ~ 5 half-lives of 228Ra, when added to the 10 yrs of 228Th-excess) towards secular equilibrium with the parent long-lived 232Th. A few algorithms provide simple models governing these processes under relatively high sedimentation rates, i.e., when Ra-diffusion from the sediment towards the water column may be neglected. In sites characterized by extreme sedimentologival events, 228Th/232Th profiles depict departures from this model, thus bearing information on the timing and processes involved. Examples from the Saguenay Fjord (Canada) illustrate the case of fast-deposited layers due to floods, whereas examples from estuaries and coastal areas of Sinaloa show evidence for re-suspension and/or erosion events linked notably to storminess and/or land use changes. In the first case, the fast accumulation of flood layers has sealed most of the early 20th-century contamination, whereas in the second case, erosion and re-suspension events led to either some removal of sediments contaminated by heavy metals, or their secondary release into the environment.

Imaging Shock Fronts in the Outer Ejecta of Eta Carinae

NASA Astrophysics Data System (ADS)

Smith, Nathan

2017-08-01

Although Eta Car has been imaged many times with HST to monitor the central star and the bright Homunculus Nebula, we propose the first WFC3 imaging of Eta Car to study the more extended Outer Ejecta from previous eruptions. WFC3 has two key filters that have not been used before to image Eta Car, which will provide critical physical information about its eruptive history: (1) F280N with WFC3/UVIS will produce the first Mg II 2800 image of Eta Car, the sharpest image of its complex Outer Ejecta, and will unambiguously trace shock fronts, and (2) F126N with WFC3/IR will sample [Fe II] 12567 arising in the densest post-shock gas. Eta Car is surrounded by a bright, soft X-ray shell seen in Chandra images, which arises from the fastest 1840s ejecta overtaking slower older material. Our recent proper motion measurements show that the outer knots were ejected in two outbursts several hundred years before the 1840s eruption, and spectroscopy of light echoes has recently revealed extremely fast ejecta during the 1840s that indicate an explosive event. Were those previous eruptions explosive as well? If so, were they as energetic, did they also have such fast ejecta, and did they have the same geometry? The structure and excitation of the Outer Ejecta hold unique clues for reconstructing Eta Car's violent mass loss history. The locations of shock fronts in circumstellar material provide critical information, because they identify past discontinuities in the mass loss. This is one of the only ways to investigate the long term (i.e. centuries) evolution and duty cycle of eruptive mass loss in the most massive stars.

Single-molecule, full-length transcript sequencing provides insight into the extreme metabolism of the ruby-throated hummingbird Archilochus colubris

PubMed Central

Workman, Rachael E; Myrka, Alexander M; Wong, G William; Tseng, Elizabeth

2018-01-01

Abstract Background Hummingbirds oxidize ingested nectar sugars directly to fuel foraging but cannot sustain this fuel use during fasting periods, such as during the night or during long-distance migratory flights. Instead, fasting hummingbirds switch to oxidizing stored lipids that are derived from ingested sugars. The hummingbird liver plays a key role in moderating energy homeostasis and this remarkable capacity for fuel switching. Additionally, liver is the principle location of de novo lipogenesis, which can occur at exceptionally high rates, such as during premigratory fattening. Yet understanding how this tissue and whole organism moderates energy turnover is hampered by a lack of information regarding how relevant enzymes differ in sequence, expression, and regulation. Findings We generated a de novo transcriptome of the hummingbird liver using PacBio full-length cDNA sequencing (Iso-Seq), yielding 8.6Gb of sequencing data, or 2.6M reads from 4 different size fractions. We analyzed data using the SMRTAnalysis v3.1 Iso-Seq pipeline, then clustered isoforms into gene families to generate de novo gene contigs using Cogent. We performed orthology analysis to identify closely related sequences between our transcriptome and other avian and human gene sets. Finally, we closely examined homology of critical lipid metabolism genes between our transcriptome data and avian and human genomes. Conclusions We confirmed high levels of sequence divergence within hummingbird lipogenic enzymes, suggesting a high probability of adaptive divergent function in the hepatic lipogenic pathways. Our results leverage cutting-edge technology and a novel bioinformatics pipeline to provide a first direct look at the transcriptome of this incredible organism. PMID:29618047

(Almost) Dark Galaxies in the ALFALFA Survey: HI-bearing Ultra-Diffuse Galaxies, and Beyond

NASA Astrophysics Data System (ADS)

Leisman, Luke; Haynes, Martha P.; Giovanelli, Riccardo; ALFALFA Almost Darks Team

2017-01-01

Scaling relations between HI and stars in galaxies suggest strong ties between their atomic gas content and star formation laws. The Arecibo Legacy Fast ALFA (ALFALFA) blind extragalactic HI survey is well positioned to locate very low surface brightness sources that lie off these relations, the most extreme of which may fall below optical detection limits. Thus, the ALFALFA (Almost) Darks Project has been investigating extreme outliers from these relations by studying the ~1% of ALFALFA sources without apparent stellar counterparts in major optical surveys. We have obtained deep HI and optical imaging of 25 of these candidate "dark" sources. We find that most "dark" sources are not extreme "(almost) dark" galaxies. A few are rare OH Megamasers, redshifted into the ALFALFA bandpass, and many are part of large galactic plumes, stretching as far as 600 kpc from their host galaxy. However, a small handful of sources appear to be galaxies with extreme stellar systems. We find multiple systems with HI mass to stellar mass ratios an order of magnitude larger than typical gas rich dwarfs. Further, we find an isolated population of HI-bearing "ultra diffuse" galaxies (UDGs), with stellar masses of dwarfs, but HI and optical radii of L* galaxies. We suggest that these sources may be related to recently reported gas poor, quiescent UDGs.

Simulation of the 23 July 2012 Extreme Space Weather Event: What if This Extremely Rare CME Was Earth Directed?

NASA Technical Reports Server (NTRS)

Ngwira, Chigomezyo M.; Pulkkinen, Antti; Mays, M. Leila; Kuznetsova, Maria M.; Galvin, A. B.; Simunac, Kristin; Baker, Daniel N.; Li, Xinlin; Zheng, Yihua; Glocer, Alex

2013-01-01

Extreme space weather events are known to cause adverse impacts on critical modern day technological infrastructure such as high-voltage electric power transmission grids. On 23 July 2012, NASA's Solar Terrestrial Relations Observatory-Ahead (STEREO-A) spacecraft observed in situ an extremely fast coronal mass ejection (CME) that traveled 0.96 astronomical units (approx. 1 AU) in about 19 h. Here we use the SpaceWeather Modeling Framework (SWMF) to perform a simulation of this rare CME.We consider STEREO-A in situ observations to represent the upstream L1 solar wind boundary conditions. The goal of this study is to examine what would have happened if this Rare-type CME was Earth-bound. Global SWMF-generated ground geomagnetic field perturbations are used to compute the simulated induced geoelectric field at specific ground-based active INTERMAGNET magnetometer sites. Simulation results show that while modeled global SYM-H index, a high-resolution equivalent of the Dst index, was comparable to previously observed severe geomagnetic storms such as the Halloween 2003 storm, the 23 July CME would have produced some of the largest geomagnetically induced electric fields, making it very geoeffective. These results have important practical applications for risk management of electrical power grids.

Recommendations for management of diabetes during Ramadan: update 2015

PubMed Central

Ibrahim, Mahmoud; Abu Al Magd, Megahed; Annabi, Firas A; Assaad-Khalil, Samir; Ba-Essa, Ebtesam M; Fahdil, Ibtihal; Karadeniz, Sehnaz; Meriden, Terry; Misha'l, Aly A; Pozzilli, Paolo; Shera, Samad; Thomas, Abraham; Bahijri, Suhad; Tuomilehto, Jaakko; Yilmaz, Temel; Umpierrez, Guillermo E

2015-01-01

Since the first ADA working group report on the recommendations for management of diabetes during Ramadan in 2005 and our update in 2010, we received many inquiries asking for regular updates on information regarding education, nutritional habits and new oral and injectable agents that may be useful for the management of patients with diabetes during Ramadan. Patients can be stratified into their risk of hypoglycemia and/or complications prior to the start of the fasting period of Ramadan. Those at high risk of hypoglycemia and with multiple diabetic complications should be advised against prolonged fasting. Even in the lower hypoglycemia risk group, adverse effects may still occur. In order to minimize adverse side effects during fasting in patients with diabetes and improve or maintain glucose control, education and discussion of glucose monitoring and treatment regimens should occur several weeks prior to Ramadan. Agents such as metformin, thiazolidinediones and dipeptidyl peptidase-4 inhibitors appear to be safe and do not need dose adjustment. Most sulfonylureas may not be used safely during Ramadan except with extreme caution; besides, older agents, such as chlorpropamide or glyburide, should not be used. Reduction of the dosage of sulfonylurea is needed depending on the degree of control prior to fasting. Misconceptions and local habits should be addressed and dealt with in any educational intervention and therapeutic planning with patients with diabetes. In this regard, efforts are still needed for controlled prospective studies in the field of efficacy and safety of the different interventions during the Ramadan Fast. PMID:26113983

Towards validated chemistry at extreme conditions: reactive MD simulations of shocked Polyvinyl Nitrate and Nitromethane

NASA Astrophysics Data System (ADS)

Islam, Md Mahbubul; Strachan, Alejandro

A detailed atomistic-level understanding of the ultrafast chemistry of detonation processes of high energy materials is crucial to understand their performance and safety. Recent advances in laser shocks and ultra-fast spectroscopy is yielding the first direct experimental evidence of chemistry at extreme conditions. At the same time, reactive molecular dynamics (MD) in current high-performance computing platforms enable an atomic description of shock-induced chemistry with length and timescales approaching those of experiments. We use MD simulations with the reactive force field ReaxFF to investigate the shock-induced chemical decomposition mechanisms of polyvinyl nitrate (PVN) and nitromethane (NM). The effect of shock pressure on chemical reaction mechanisms and kinetics of both the materials are investigated. For direct comparison of our simulation results with experimentally derived IR absorption data, we performed spectral analysis using atomistic velocity at various shock conditions. The combination of reactive MD simulations and ultrafast spectroscopy enables both the validation of ReaxFF at extreme conditions and contributes to the interpretation of the experimental data relating changes in spectral features to atomic processes. Office of Naval Research MURI program.

Extreme natural acidification in the East Siberian Arctic Shelf: Effects of permafrost thawing and seawater freshening

NASA Astrophysics Data System (ADS)

Semiletov, I. P.; Pipko, I.; Gustafsson, O.; Anderson, L. G.; Sergienko, V.; Pugach, S.; Dudarev, O.; Charkin, A. N.; Gukov, A.; Bröder, L.; Andersson, A.; Shakhova, N. E.

2015-12-01

Ocean acidification (OA) is a direct, fast, and strong effect of anthropogenic carbon dioxide (CO2), which is challenging marine ecosystems and carbon cycling. The Arctic Ocean is particularly sensitive and exhibits the highest levels of OA (lowest pH) because more CO2 can dissolve in cold water. We here use decadal data to show that extreme and extensive OA in the East Siberian Arctic Shelf (ESAS) is caused not by direct uptake of atmospheric CO2 but rather by naturally-driven processes: carbon mobilization from thawing coastal permafrost/coastal ice complexes, and freshening due to growing Arctic river runoff and ice melt, which transport carbon along with freshwater to the ESAS. These processes compose a unique acidifying phenomenon that causes persistent, and potentially increasing, aragonite under-saturation of the entire water column. Extreme aragonite under-saturation in the western near-shore ESAS is associated with >80% depression of the total calcifying benthic biomass. Massive OA on the ESAS, the largest sea shelf system of the World Ocean, illustrates the complexity of the Earth system interacting with increasing anthropogenic pressure.

High-resolution, time-resolved MRA provides superior definition of lower-extremity arterial segments compared to 2D time-of-flight imaging.

PubMed

Thornton, F J; Du, J; Suleiman, S A; Dieter, R; Tefera, G; Pillai, K R; Korosec, F R; Mistretta, C A; Grist, T M

2006-08-01

To evaluate a novel time-resolved contrast-enhanced (CE) projection reconstruction (PR) magnetic resonance angiography (MRA) method for identifying potential bypass graft target vessels in patients with Class II-IV peripheral vascular disease. Twenty patients (M:F = 15:5, mean age = 58 years, range = 48-83 years), were recruited from routine MRA referrals. All imaging was performed on a 1.5 T MRI system with fast gradients (Signa LX; GE Healthcare, Waukesha, WI). Images were acquired with a novel technique that combined undersampled PR with a time-resolved acquisition to yield an MRA method with high temporal and spatial resolution. The method is called PR hyper time-resolved imaging of contrast kinetics (PR-hyperTRICKS). Quantitative and qualitative analyses were used to compare two-dimensional (2D) time-of-flight (TOF) and PR-hyperTRICKS in 13 arterial segments per lower extremity. Statistical analysis was performed with the Wilcoxon signed-rank test. Fifteen percent (77/517) of the vessels were scored as missing or nondiagnostic with 2D TOF, but were scored as diagnostic with PR-hyperTRICKS. Image quality was superior with PR-hyperTRICKS vs. 2D TOF (on a four-point scale, mean rank = 3.3 +/- 1.2 vs. 2.9 +/- 1.2, P < 0.0001). PR-hyperTRICKS produced images with high contrast-to-noise ratios (CNR) and high spatial and temporal resolution. 2D TOF images were of inferior quality due to moderate spatial resolution, inferior CNR, greater flow-related artifacts, and absence of temporal resolution. PR-hyperTRICKS provides superior preoperative assessment of lower limb ischemia compared to 2D TOF.

ELF (Extremely Low Frequency) Communications System - Ecological Monitoring Program: Summary of 1988 Progress

DTIC Science & Technology

1989-11-01

of fresh leaves are fast at both sites. 3 Similar comparisons using autumn abscised leaves show intermediate processing rates at the treatment site...processing fresh or autumn- abscised leaves during 1988 (t-test). Analyses of variance showed that fresh leaves were pricessed significantly faster at the...Northern Journal of Applied Forestry, 5:14, 1988. 22 Connaughton, P. The effects of acid precipi*ation on nutrient levels in a forest soil and foliage of

Evaluation of Oxygen Concentrators and Chemical Oxygen Generators at Altitude and Temperature Extremes

DTIC Science & Technology

2015-04-22

ceased. Oxygen concentration was continuously measured with a fast laser diode oxygen analyzer (O2CAP, Oxigraf, Inc., Mountain View, CA) throughout the...duration of operation. The output generated from the COGs was analyzed by a gas mass spectrometer (QGA model HAS 301, Hiden Analytical, Livonia, MI...throughout the range of bolus volumes with each device at respiratory rates of 20 and 30 breaths /min with each bolus setting. Data were recorded every

FAST TRACK COMMUNICATION Single-charge rotating black holes in four-dimensional gauged supergravity

NASA Astrophysics Data System (ADS)

Chow, David D. K.

2011-02-01

We consider four-dimensional U(1)4 gauged supergravity, and obtain asymptotically AdS4, non-extremal, charged, rotating black holes with one non-zero U(1) charge. The thermodynamic quantities are computed. We obtain a generalization that includes a NUT parameter. The general solution has a discrete symmetry involving inversion of the rotation parameter, and has a string frame metric that admits a rank-2 Killing-Stäckel tensor.

Overcoming the Coupling Dilemma in DNA-Programmable Nanoparticle Assemblies by "Ag+ Soldering".

PubMed

Wang, Huiqiao; Li, Yulin; Liu, Miao; Gong, Ming; Deng, Zhaoxiang

2015-05-20

Strong coupling between nanoparticles is critical for facilitating charge and energy transfers. Despite the great success of DNA-programmable nanoparticle assemblies, the very weak interparticle coupling represents a key barrier to various applications. Here, an extremely simple, fast, and highly efficient process combining DNA-programming and molecular/ionic bonding is developed to address this challenge, which exhibits a seamless fusion with DNA nanotechnology. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Characteristics and Outcomes of Very Elderly Enrolled in a Prehospital Stroke Research Study.

PubMed

Sanossian, Nerses; Apibunyopas, Kathleen C; Liebeskind, David S; Starkman, Sidney; Burgos, Adrian M; Conwit, Robin; Eckstein, Marc; Pratt, Frank; Stratton, Sam; Hamilton, Scott; Saver, Jeffrey L

2016-11-01

Greater numbers of individuals aged ≥80 years enjoy a high quality of life, yet historically stroke trials have excluded this population. We aimed to describe a population of very elderly successfully enrolled into an acute stroke trial and compare their characteristics and outcomes with the younger cohort. We analyzed consecutive patients enrolled <2 hours of symptom onset in a prehospital stroke treatment trial, the FAST-MAG clinical trial (Field Administration of Stroke Therapy-Magnesium). We gathered demographic, treatment, and outcome data for nonelderly (<80 years old), very elderly (≥80 years old), and extreme elderly (≥90 years old). We describe key differences in the population of elderly and the impact of their inclusion on the clinical trial. Of 1700 participants in FAST-MAG, there were 1210 nonelderly, 490 very elderly, and 60 extreme elderly subjects. Very elderly stroke patients successfully enrolled in a research study were more likely to be women, white, and have an ischemic mechanism rather than an intracerebral hemorrhage. Although the very elderly had generally poorer outcomes, 4 in 10 were functionally independent at 90 days. Inclusion of the very elderly population in acute stroke clinical trials would both significantly increase study participation and generalizability of future acute stroke clinical trials. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332. © 2016 American Heart Association, Inc.

EUV multilayer defect compensation (MDC) by absorber pattern modification: from theory to wafer validation

NASA Astrophysics Data System (ADS)

Pang, Linyong; Hu, Peter; Satake, Masaki; Tolani, Vikram; Peng, Danping; Li, Ying; Chen, Dongxue

2011-11-01

According to the ITRS roadmap, mask defects are among the top technical challenges to introduce extreme ultraviolet (EUV) lithography into production. Making a multilayer defect-free extreme ultraviolet (EUV) blank is not possible today, and is unlikely to happen in the next few years. This means that EUV must work with multilayer defects present on the mask. The method proposed by Luminescent is to compensate effects of multilayer defects on images by modifying the absorber patterns. The effect of a multilayer defect is to distort the images of adjacent absorber patterns. Although the defect cannot be repaired, the images may be restored to their desired targets by changing the absorber patterns. This method was first introduced in our paper at BACUS 2010, which described a simple pixel-based compensation algorithm using a fast multilayer model. The fast model made it possible to complete the compensation calculations in seconds, instead of days or weeks required for rigorous Finite Domain Time Difference (FDTD) simulations. Our SPIE 2011 paper introduced an advanced compensation algorithm using the Level Set Method for 2D absorber patterns. In this paper the method is extended to consider process window, and allow repair tool constraints, such as permitting etching but not deposition. The multilayer defect growth model is also enhanced so that the multilayer defect can be "inverted", or recovered from the top layer profile using a calibrated model.

Radar HRRP Target Recognition Based on Stacked Autoencoder and Extreme Learning Machine

PubMed Central

Liu, Yongxiang; Huo, Kai; Zhang, Zhongshuai

2018-01-01

A novel radar high-resolution range profile (HRRP) target recognition method based on a stacked autoencoder (SAE) and extreme learning machine (ELM) is presented in this paper. As a key component of deep structure, the SAE does not only learn features by making use of data, it also obtains feature expressions at different levels of data. However, with the deep structure, it is hard to achieve good generalization performance with a fast learning speed. ELM, as a new learning algorithm for single hidden layer feedforward neural networks (SLFNs), has attracted great interest from various fields for its fast learning speed and good generalization performance. However, ELM needs more hidden nodes than conventional tuning-based learning algorithms due to the random set of input weights and hidden biases. In addition, the existing ELM methods cannot utilize the class information of targets well. To solve this problem, a regularized ELM method based on the class information of the target is proposed. In this paper, SAE and the regularized ELM are combined to make full use of their advantages and make up for each of their shortcomings. The effectiveness of the proposed method is demonstrated by experiments with measured radar HRRP data. The experimental results show that the proposed method can achieve good performance in the two aspects of real-time and accuracy, especially when only a few training samples are available. PMID:29320453

Radar HRRP Target Recognition Based on Stacked Autoencoder and Extreme Learning Machine.

PubMed

Zhao, Feixiang; Liu, Yongxiang; Huo, Kai; Zhang, Shuanghui; Zhang, Zhongshuai

2018-01-10

A novel radar high-resolution range profile (HRRP) target recognition method based on a stacked autoencoder (SAE) and extreme learning machine (ELM) is presented in this paper. As a key component of deep structure, the SAE does not only learn features by making use of data, it also obtains feature expressions at different levels of data. However, with the deep structure, it is hard to achieve good generalization performance with a fast learning speed. ELM, as a new learning algorithm for single hidden layer feedforward neural networks (SLFNs), has attracted great interest from various fields for its fast learning speed and good generalization performance. However, ELM needs more hidden nodes than conventional tuning-based learning algorithms due to the random set of input weights and hidden biases. In addition, the existing ELM methods cannot utilize the class information of targets well. To solve this problem, a regularized ELM method based on the class information of the target is proposed. In this paper, SAE and the regularized ELM are combined to make full use of their advantages and make up for each of their shortcomings. The effectiveness of the proposed method is demonstrated by experiments with measured radar HRRP data. The experimental results show that the proposed method can achieve good performance in the two aspects of real-time and accuracy, especially when only a few training samples are available.

A fast and accurate online sequential learning algorithm for feedforward networks.

PubMed

Liang, Nan-Ying; Huang, Guang-Bin; Saratchandran, P; Sundararajan, N

2006-11-01

In this paper, we develop an online sequential learning algorithm for single hidden layer feedforward networks (SLFNs) with additive or radial basis function (RBF) hidden nodes in a unified framework. The algorithm is referred to as online sequential extreme learning machine (OS-ELM) and can learn data one-by-one or chunk-by-chunk (a block of data) with fixed or varying chunk size. The activation functions for additive nodes in OS-ELM can be any bounded nonconstant piecewise continuous functions and the activation functions for RBF nodes can be any integrable piecewise continuous functions. In OS-ELM, the parameters of hidden nodes (the input weights and biases of additive nodes or the centers and impact factors of RBF nodes) are randomly selected and the output weights are analytically determined based on the sequentially arriving data. The algorithm uses the ideas of ELM of Huang et al. developed for batch learning which has been shown to be extremely fast with generalization performance better than other batch training methods. Apart from selecting the number of hidden nodes, no other control parameters have to be manually chosen. Detailed performance comparison of OS-ELM is done with other popular sequential learning algorithms on benchmark problems drawn from the regression, classification and time series prediction areas. The results show that the OS-ELM is faster than the other sequential algorithms and produces better generalization performance.

High-speed duetting - latency times of the female acoustic response within the bush-cricket genera Leptophyes and Andreiniimon (Orthoptera, Phaneropteridae).

PubMed

Heller, Klaus-Gerhard; Korsunovskaya, Olga; Massa, Bruno; Iorgu, Ionuț Ștefan

2018-01-01

To find a mate, male and female bush-crickets of the family Phaneropteridae typically engage in duets. The male sings and the female responds. For mutual recognition, the amplitude pattern of the male song and the species-specific timing of the female response have been shown to be very important. In the seven studied species, belonging to the genera Leptophyes and Andreiniimon , these duets are extremely fast and nearly completely in the ultrasonic range. The females produce very short sounds by fast closing movements of the tegmina. They respond with species-specific delays of 20 to 150 ms after the beginning of the male song. The different latency times are probably not important for species recognition, since in sympatric species they are quite similar.

Fast novel nonlinear optical NLC system with local response

NASA Astrophysics Data System (ADS)

Iljin, Andrey; Residori, Stefania; Bortolozzo, Umberto

2017-06-01

Nonlinear optical performance of a novel liquid crystalline (LC) cell has been studied in two-wave mixing experiments revealing high diffraction efficiency within extremely wide intensity range, fast recording times and spatial resolution. Photo-induced modulation of the LC order parameter resulting from trans-cis isomerisation of dye molecules causes consequent changes of refractive indices of the medium (Light-Induced Order Modification, LIOM-mechanism) and is proved to be the main mechanism of optical nonlinearity. The proposed arrangement of the electric-field-stabilised homeotropic alignment hinders the LC director reorientation, prevents appearance of surface effects and ensures the optical cell quality. The LIOM-type nonlinearity, characterised with the substantially local nonlinear optical response, could also be extended for the recording of arbitrary phase profiles as requested in several applications for light-beam manipulation, recording of dynamic volume holograms and photonic lattices.

High-speed duetting – latency times of the female acoustic response within the bush-cricket genera Leptophyes and Andreiniimon (Orthoptera, Phaneropteridae)

PubMed Central

Heller, Klaus-Gerhard; Korsunovskaya, Olga; Massa, Bruno; Iorgu, Ionuț Ștefan

2018-01-01

Abstract To find a mate, male and female bush-crickets of the family Phaneropteridae typically engage in duets. The male sings and the female responds. For mutual recognition, the amplitude pattern of the male song and the species-specific timing of the female response have been shown to be very important. In the seven studied species, belonging to the genera Leptophyes and Andreiniimon, these duets are extremely fast and nearly completely in the ultrasonic range. The females produce very short sounds by fast closing movements of the tegmina. They respond with species-specific delays of 20 to 150 ms after the beginning of the male song. The different latency times are probably not important for species recognition, since in sympatric species they are quite similar. PMID:29692644

Enhanced hole boring with two-color relativistic laser pulses in the fast ignition scheme

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Changhai; Tian, Ye; Li, Wentao

A scheme of using two-color laser pulses for hole boring into overdense plasma as well as energy transfer into electron and ion beams has been studied using particle-in-cell simulations. Following an ultra-short ultra-intense hole-boring laser pulse with a short central wavelength in extreme ultra-violet range, the main infrared driving laser pulse can be guided in the hollow channel preformed by the former laser and propagate much deeper into an overdense plasma, as compared to the case using the infrared laser only. In addition to efficiently transferring the main driving laser energy into energetic electrons and ions generation deep inside themore » overdense plasma, the ion beam divergence can be greatly reduced. The results might be beneficial for the fast ignition concept of inertial confinement fusion.« less

Ramadan fasting and diabetes: an observational study among Turkish migrants in Belgium.

PubMed

Peeters, Bart; Mehuys, Els; Van Tongelen, Inge; Van Bever, Elien; Bultereys, Lore; Avonts, Dirk; Yıldız, Güven; Remon, Jean Paul; Boussery, Koen

2012-12-01

To investigate (i) Ramadan participation, (ii) provision of Ramadan-related advice by healthcare providers, (iii) medication use during Ramadan fasting among Turkish migrants with diabetes in Belgium. This pilot observational study was conducted among a convenience sample of 52 Turkish migrants with diabetes in Belgium. Two questionnaires collected information on socio-demographic characteristics, diabetes-related characteristics, current hypoglycaemic medication with dosing regimen, participation in the past Ramadan, reasons for (non-)participation, use of hypoglycaemic medication during the past Ramadan, advice from their healthcare providers about fasting during Ramadan and follow-up of this advice. Sixteen patients (31%) had fasted during the past Ramadan. Main reason for Ramadan participation was reinforcement of faith (12/15), while the main reason for non-participation was having diabetes (34/36). About 56% of the study population had received recommendations from their healthcare provider(s) about fasting and diabetes during Ramadan. The most commonly provided advice was not to participate in Ramadan, followed by modification of drug therapy. Only 3 patients ignored the advice of their health professionals. In addition, only 60% of those who actually fasted received recommendations about intake of diabetes medication during the Ramadan. Most fasters continued their medication dose unchanged (87% of OHA users and 80% of the insulin users). This pilot study found a low prevalence of Ramadan fasting among Turkish migrants with diabetes in Belgium. We also found that provision of advice by healthcare providers could be improved. Larger scale studies are warranted to confirm these findings. Copyright © 2012 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

The availability and accessibility of nutrition information in fast food outlets in five states post-menu labelling legislation in New South Wales.

PubMed

Wellard, Lyndal; Havill, Michelle; Hughes, Clare; Watson, Wendy L; Chapman, Kathy

2015-12-01

1) Explore the availability and accessibility of fast food energy and nutrient information post-NSW menu labelling legislation in states with and without menu labelling legislation. 2) Determine whether availability and accessibility differed compared with pre-menu labelling legislation in NSW. We visited 210 outlets of the five largest fast food chains in five Australian states to observe the availability and accessibility of energy and nutrient information. Results were compared with 197 outlets surveyed pre-menu labelling. Most outlets (95%) provided energy values, half provided nutrient values and 3% provided information for all menu items. The total amount of information available increased post-NSW menu labelling implementation (473 versus 178 pre-implementation, p<0.001); however, fewer outlets provided nutrient values (26% versus 97% pre-implementation, p<0.001). Fast food chains surveyed had voluntarily introduced menu labelling nationally. However, more nutrient information was available in-store in 2010, showing that fast food chains are able to provide comprehensive nutrition information, yet they have stopped doing so. Menu labelling legislation should compel fast food chains to provide accessible nutrition information including nutrient values in addition to energy for all menu items in-store. Additionally, public education campaigns are needed to ensure customers can use menu labelling. © 2015 Public Health Association of Australia.

Task-specific recruitment of motor units for vibration damping.

PubMed

Wakeling, James M; Liphardt, Anna-Maria

2006-01-01

Vibrations occur within the soft tissues of the lower extremities due to the heel-strike impact during walking. Increases in muscle activity in the lower extremities result in increased damping to reduce this vibration. The myoelectric intensity spectra were compared using principal component analysis from the tibialis anterior and lateral gastrocnemius of 40 subjects walking with different shoe conditions. The soft insert condition resulted in a significant, simultaneous increase in muscle activity with a shift to higher myoelectric frequencies in the period 0-60 ms after heel-strike which is the period when the greater vibration damping occurred. These increases in myoelectric frequency match the spectral patterns which indicate increases in recruitment of faster motor units. It is concluded that fast motor units are recruited during the task of damping the soft-tissue resonance that occurs following heel-strike.

Soapy: an adaptive optics simulation written purely in Python for rapid concept development

NASA Astrophysics Data System (ADS)

Reeves, Andrew

2016-07-01

Soapy is a newly developed Adaptive Optics (AO) simulation which aims be a flexible and fast to use tool-kit for many applications in the field of AO. It is written purely in the Python language, adding to and taking advantage of the already rich ecosystem of scientific libraries and programs. The simulation has been designed to be extremely modular, such that each component can be used stand-alone for projects which do not require a full end-to-end simulation. Ease of use, modularity and code clarity have been prioritised at the expense of computational performance. Though this means the code is not yet suitable for large studies of Extremely Large Telescope AO systems, it is well suited to education, exploration of new AO concepts and investigations of current generation telescopes.

Extreme geomagnetically induced currents

NASA Astrophysics Data System (ADS)

Kataoka, Ryuho; Ngwira, Chigomezyo

2016-12-01

We propose an emergency alert framework for geomagnetically induced currents (GICs), based on the empirically extreme values and theoretical upper limits of the solar wind parameters and of d B/d t, the time derivative of magnetic field variations at ground. We expect this framework to be useful for preparing against extreme events. Our analysis is based on a review of various papers, including those presented during Extreme Space Weather Workshops held in Japan in 2011, 2012, 2013, and 2014. Large-amplitude d B/d t values are the major cause of hazards associated with three different types of GICs: (1) slow d B/d t with ring current evolution (RC-type), (2) fast d B/d t associated with auroral electrojet activity (AE-type), and (3) transient d B/d t of sudden commencements (SC-type). We set "caution," "warning," and "emergency" alert levels during the main phase of superstorms with the peak Dst index of less than -300 nT (once per 10 years), -600 nT (once per 60 years), or -900 nT (once per 100 years), respectively. The extreme d B/d t values of the AE-type GICs are 2000, 4000, and 6000 nT/min at caution, warning, and emergency levels, respectively. For the SC-type GICs, a "transient alert" is also proposed for d B/d t values of 40 nT/s at low latitudes and 110 nT/s at high latitudes, especially when the solar energetic particle flux is unusually high.

Perceptions and practices of fasting in Ramadan during pregnancy in Pakistan

PubMed Central

Mubeen, Syed M.; Mansoor, Salman; Hussain, Asad; Qadir, Shayan

2012-01-01

Background: Islam clearly exempts fasting in Ramadan during sickness, pregnancy, and breastfeeding. Yet, some women prefer to fast despite realizing their increase in nutritional demand during pregnancy. Nurses and other healthcare providers face a difficult task of providing appropriate medical advice to Muslim women regarding the safety and impact of their fasting. The present study was conducted to examine the concepts and practices of maternal fasting during pregnancy in Pakistani Muslim women. Materials and Methods: A cross-sectional study was done in 2008 on 353 females from gynecology departments of hospitals in major cities of two provinces of Pakistan. Non-probability convenient sampling technique was used and a questionnaire was used to collect data from females who had experienced pregnancy during Ramadan at least once in life. Questions related to perceptions and practices of fasting in pregnancy along with demographic data were asked. Analysis was done on SPSS version 16. Chi-square test was used to assess associations and P < 0.05 was considered statistically significant. All ethical considerations were taken into account for the respondents. Results: Out of the total, 309 (87.5%) fasted during their pregnancies while 43 (12.5%) did not fast at all. Among those who fasted, 42.5% (n = 150) fasted for the whole month, 23.8% (n = 84) fasted on alternate days, 10.5% (n = 37) fasted only on weekends/holidays, and 10.8% (n = 38) fasted on particular special days. The majority perceived no harm and risk caused by fasting to them or to fetus during pregnancy. Although adverse effects during fasting were frequently reported, only 24% break their fast. A significant association was found between gravida and education with fasting (P w< 0.05). A total of 88% of women believed that fasting during pregnancy (in good health) is “obligatory” while 12% thought otherwise. Conclusion: Pakistani Muslim women showed a strong compassion for fasting in pregnancy despite overall decrease in maternal health indicators. There is a need for nurses and other healthcare providers in all Muslim countries and especially in non-Muslim countries with cultural diversity to be fully aware of the effects of fasting in pregnancy so that they can act promptly ensuring safe and healthy delivery. PMID:23922591

Coordinated Hard Sphere Mixture (CHaSM): A fast approximate model for oxide and silicate melts at extreme conditions

NASA Astrophysics Data System (ADS)

Wolf, A. S.; Asimow, P. D.; Stevenson, D. J.

2015-12-01

Recent first-principles calculations (e.g. Stixrude, 2009; de Koker, 2013), shock-wave experiments (Mosenfelder, 2009), and diamond-anvil cell investigations (Sanloup, 2013) indicate that silicate melts undergo complex structural evolution at high pressure. The observed increase in cation-coordination (e.g. Karki, 2006; 2007) induces higher compressibilities and lower adiabatic thermal gradients in melts as compared with their solid counterparts. These properties are crucial for understanding the evolution of impact-generated magma oceans, which are dominated by the poorly understood behavior of silicates at mantle pressures and temperatures (e.g. Stixrude et al. 2009). Probing these conditions is difficult for both theory and experiment, especially given the large compositional space (MgO-SiO2-FeO-Al2O3-etc). We develop a new model to understand and predict the behavior of oxide and silicate melts at extreme P-T conditions (Wolf et al., 2015). The Coordinated Hard Sphere Mixture (CHaSM) extends the Hard Sphere mixture model, accounting for the range of coordination states for each cation in the liquid. Using approximate analytic expressions for the hard sphere model, this fast statistical method compliments classical and first-principles methods, providing accurate thermodynamic and structural property predictions for melts. This framework is applied to the MgO system, where model parameters are trained on a collection of crystal polymorphs, producing realistic predictions of coordination evolution and the equation of state of MgO melt over a wide P-T range. Typical Mg-coordination numbers are predicted to evolve continuously from 5.25 (0 GPa) to 8.5 (250 GPa), comparing favorably with first-principles Molecular Dynamics (MD) simulations. We begin extending the model to a simplified mantle chemistry using empirical potentials (generally accurate over moderate pressure ranges, <~30 GPa), yielding predictions rooted in statistical representations of melt structure that compare well with more time-consuming classical MD calculations. This approach also sheds light on the universality of the increasing Grüneisen parameter trend for liquids (opposite that of solids), which directly reflects their progressive evolution toward more compact solid-like structures upon compression.

Statistical emulators of maize, rice, soybean and wheat yields from global gridded crop models

DOE PAGES

Blanc, Élodie

2017-01-26

This study provides statistical emulators of crop yields based on global gridded crop model simulations from the Inter-Sectoral Impact Model Intercomparison Project Fast Track project. The ensemble of simulations is used to build a panel of annual crop yields from five crop models and corresponding monthly summer weather variables for over a century at the grid cell level globally. This dataset is then used to estimate, for each crop and gridded crop model, the statistical relationship between yields, temperature, precipitation and carbon dioxide. This study considers a new functional form to better capture the non-linear response of yields to weather,more » especially for extreme temperature and precipitation events, and now accounts for the effect of soil type. In- and out-of-sample validations show that the statistical emulators are able to replicate spatial patterns of yields crop levels and changes overtime projected by crop models reasonably well, although the accuracy of the emulators varies by model and by region. This study therefore provides a reliable and accessible alternative to global gridded crop yield models. By emulating crop yields for several models using parsimonious equations, the tools provide a computationally efficient method to account for uncertainty in climate change impact assessments.« less

Statistical emulators of maize, rice, soybean and wheat yields from global gridded crop models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanc, Élodie

This study provides statistical emulators of crop yields based on global gridded crop model simulations from the Inter-Sectoral Impact Model Intercomparison Project Fast Track project. The ensemble of simulations is used to build a panel of annual crop yields from five crop models and corresponding monthly summer weather variables for over a century at the grid cell level globally. This dataset is then used to estimate, for each crop and gridded crop model, the statistical relationship between yields, temperature, precipitation and carbon dioxide. This study considers a new functional form to better capture the non-linear response of yields to weather,more » especially for extreme temperature and precipitation events, and now accounts for the effect of soil type. In- and out-of-sample validations show that the statistical emulators are able to replicate spatial patterns of yields crop levels and changes overtime projected by crop models reasonably well, although the accuracy of the emulators varies by model and by region. This study therefore provides a reliable and accessible alternative to global gridded crop yield models. By emulating crop yields for several models using parsimonious equations, the tools provide a computationally efficient method to account for uncertainty in climate change impact assessments.« less

Fasting-induced daily torpor in desert hamsters (Phodopus roborovskii).

PubMed

Chi, Qing-Sheng; Wan, Xin-Rong; Geiser, Fritz; Wang, De-Hua

2016-09-01

Daily torpor is frequently expressed in small rodents when facing energetically unfavorable ambient conditions. Desert hamsters (Phodopus roborovskii, ~20g) appear to be an exception as they have been described as homeothermic. However, we hypothesized that they can use torpor because we observed reversible decreases of body temperature (Tb) in fasted hamsters. To test this hypothesis we (i) randomly exposed fasted summer-acclimated hamsters to ambient temperatures (Tas) ranging from 5 to 30°C or (ii) supplied them with different rations of food at Ta 23°C. All desert hamsters showed heterothermy with the lowest mean Tb of 31.4±1.9°C (minimum, 29.0°C) and 31.8±2.0°C (minimum, 29.0°C) when fasted at Ta of 23°C and 19°C, respectively. Below Ta 19°C, the lowest Tb and metabolic rate increased and the proportion of hamsters using heterothermy declined. At Ta 5°C, nearly all hamsters remained normothermic by increasing heat production, suggesting that the heterothermy only occurs in moderately cold conditions, perhaps to avoid freezing at extremely low Tas. During heterothermy, Tbs below 31°C with metabolic rates below 25% of those during normothermia were detected in four individuals at Ta of 19°C and 23°C. Consequently, by definition, our observations confirm that fasted desert hamsters are capable of shallow daily torpor. The negative correlation between the lowest Tbs and amount of food supply shows that heterothermy was mainly triggered by food shortage. Our data indicate that summer-acclimated desert hamsters can express fasting-induced shallow daily torpor, which may be of significance for energy conservation and survival in the wild. Copyright © 2016 Elsevier Inc. All rights reserved.

Rapid weather information dissemination in Florida

NASA Technical Reports Server (NTRS)

Martsolf, J. D.; Heinemann, P. H.; Gerber, J. F.; Crosby, F. L.; Smith, D. L.

1984-01-01

The development of the Florida Agricultural Services and Technology (FAST) plan to provide ports for users to call for weather information is described. FAST is based on the Satellite Frost Forecast System, which makes a broad base of weather data available to its users. The methods used for acquisition and dissemination of data from various networks under the FAST plan are examined. The system provides color coded IR or thermal maps, precipitation maps, and textural forecast information. A diagram of the system is provided.

Fast protein folding kinetics

PubMed Central

Gelman, Hannah; Gruebele, Martin

2014-01-01

Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

Hydrogen Financial Analysis Scenario Tool (H2FAST). Web Tool User's Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bush, B.; Penev, M.; Melaina, M.

The Hydrogen Financial Analysis Scenario Tool (H2FAST) provides a quick and convenient indepth financial analysis for hydrogen fueling stations. This manual describes how to use the H2FAST web tool, which is one of three H2FAST formats developed by the National Renewable Energy Laboratory (NREL). Although all of the formats are based on the same financial computations and conform to generally accepted accounting principles (FASAB 2014, Investopedia 2014), each format provides a different level of complexity and user interactivity.

CONTROL SYSTEM FOR NEUTRONIC REACTORS

DOEpatents

Crever, F.E.

1962-05-01

BS>A slow-acting shim rod for control of major variations in reactor neutron flux and a fast-acting control rod to correct minor flux variations are employed to provide a sensitive, accurate control system. The fast-acting rod is responsive to an error signal which is produced by changes in the neutron flux from a predetermined optimum level. When the fast rod is thus actuated in a given direction, means is provided to actuate the slow-moving rod in that direction to return the fast rod to a position near the midpoint of its control range. (AEC)

Probing disorder in isometric pyrochlore and related complex oxides

NASA Astrophysics Data System (ADS)

Shamblin, Jacob; Feygenson, Mikhail; Neuefeind, Joerg; Tracy, Cameron L.; Zhang, Fuxiang; Finkeldei, Sarah; Bosbach, Dirk; Zhou, Haidong; Ewing, Rodney C.; Lang, Maik

2016-05-01

There has been an increased focus on understanding the energetics of structures with unconventional ordering (for example, correlated disorder that is heterogeneous across different length scales). In particular, compounds with the isometric pyrochlore structure, A2B2O7, can adopt a disordered, isometric fluorite-type structure, (A, B)4O7, under extreme conditions. Despite the importance of the disordering process there exists only a limited understanding of the role of local ordering on the energy landscape. We have used neutron total scattering to show that disordered fluorite (induced intrinsically by composition/stoichiometry or at far-from-equilibrium conditions produced by high-energy radiation) consists of a local orthorhombic structural unit that is repeated by a pseudo-translational symmetry, such that orthorhombic and isometric arrays coexist at different length scales. We also show that inversion in isometric spinel occurs by a similar process. This insight provides a new basis for understanding order-to-disorder transformations important for applications such as plutonium immobilization, fast ion conduction, and thermal barrier coatings.

VAMPIRES: probing the innermost regions of protoplanetary systems with polarimetric aperture-masking

NASA Astrophysics Data System (ADS)

Norris, Barnaby R. M.; Tuthill, Peter G.; Jovanovic, Nemanja; Schworer, Guillaume; Guyon, Olivier; Martinache, Frantz; Stewart, Paul N.

2014-07-01

VAMPIRES is a high-angular resolution imager developed to directly image planet-forming circumstellar disks, and the signatures of forming planets that lie within. The instrument leverages aperture masking interferometry - providing diffraction-limited imaging despite seeing - in combination with fast-switching differential polarimetry to directly image structure in the inner-most regions of protoplanetary systems. VAMPIRES will use starlight scattered by dust in such systems to precisely map the disk, gaps, knots and waves that are key to understanding disk evolution and planet formation. It also promises to image the dusty circumstellar environments of AGB stars. This instrument perfectly compliments coronagraphic observations in the near-IR, and can operate simultaneously with a coronagraph, as part of the SCExAO extreme-AO system at the Subaru telescope. In this paper the design of the instrument will be presented, along with an explanation of the unique data analysis process and the results of the first on-sky tests.

Distal mdx muscle groups exhibiting up-regulation of utrophin and rescue of dystrophin-associated glycoproteins exemplify a protected phenotype in muscular dystrophy

NASA Astrophysics Data System (ADS)

Dowling, Paul; Culligan, Kevin; Ohlendieck, Kay

2002-02-01

Unique unaffected skeletal muscle fibres, unlike necrotic torso and limb muscles, may pave the way for a more detailed understanding of the molecular pathogenesis of inherited neuromuscular disorders and help to develop new treatment strategies for muscular dystrophies. The sparing of extraocular muscle in Duchenne muscular dystrophy is mostly attributed to the special protective properties of extremely fast-twitching small-diameter fibres, but here we show that distal muscles also represent a particular phenotype that is more resistant to necrosis. Immunoblot analysis of membranes isolated from the well established dystrophic animal model mdx shows that, in contrast to dystrophic limb muscles, the toe musculature exhibits an up-regulation of the autosomal dystrophin homologue utrophin and a concomitant rescue of dystrophin-associated glycoproteins. Thus distal mdx muscle groups provide a cellular system that naturally avoids myofibre degeneration which might be useful in the search for naturally occurring compensatory mechanisms in inherited skeletal muscle diseases.

From kissing to belly stridulation: comparative analysis reveals surprising diversity, rapid evolution, and much homoplasy in the mating behaviour of 27 species of sepsid flies (Diptera: Sepsidae).

PubMed

Puniamoorthy, N; Ismail, M R B; Tan, D S H; Meier, R

2009-11-01

Our understanding of how fast mating behaviour evolves in insects is rather poor due to a lack of comparative studies among insect groups for which phylogenetic relationships are known. Here, we present a detailed study of the mating behaviour of 27 species of Sepsidae (Diptera) for which a well-resolved and supported phylogeny is available. We demonstrate that mating behaviour is extremely diverse in sepsids with each species having its own mating profile. We define 32 behavioural characters and document them with video clips. Based on sister species comparisons, we provide several examples where mating behaviour evolves faster than all sexually dimorphic morphological traits. Mapping the behaviours onto the molecular tree reveals much homoplasy, comparable to that observed for third positions of mitochondrial protein-encoding genes. A partitioned Bremer support (PBS) analysis reveals conflict between the molecular and behavioural data, but behavioural characters have higher PBS values per parsimony-informative character than DNA sequence characters.

TuMore: generation of synthetic brain tumor MRI data for deep learning based segmentation approaches

NASA Astrophysics Data System (ADS)

Lindner, Lydia; Pfarrkirchner, Birgit; Gsaxner, Christina; Schmalstieg, Dieter; Egger, Jan

2018-03-01

Accurate segmentation and measurement of brain tumors plays an important role in clinical practice and research, as it is critical for treatment planning and monitoring of tumor growth. However, brain tumor segmentation is one of the most challenging tasks in medical image analysis. Since manual segmentations are subjective, time consuming and neither accurate nor reliable, there exists a need for objective, robust and fast automated segmentation methods that provide competitive performance. Therefore, deep learning based approaches are gaining interest in the field of medical image segmentation. When the training data set is large enough, deep learning approaches can be extremely effective, but in domains like medicine, only limited data is available in the majority of cases. Due to this reason, we propose a method that allows to create a large dataset of brain MRI (Magnetic Resonance Imaging) images containing synthetic brain tumors - glioblastomas more specifically - and the corresponding ground truth, that can be subsequently used to train deep neural networks.

Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space

PubMed Central

Blainey, Paul C.; Graziano, Vito; Pérez-Berná, Ana J.; McGrath, William J.; Flint, S. Jane; San Martín, Carmen; Xie, X. Sunney; Mangel, Walter F.

2013-01-01

Precursor proteins used in the assembly of adenovirus virions must be processed by the virally encoded adenovirus proteinase (AVP) before the virus particle becomes infectious. An activated adenovirus proteinase, the AVP-pVIc complex, was shown to slide along viral DNA with an extremely fast one-dimensional diffusion constant, 21.0 ± 1.9 × 106 bp2/s. In principle, one-dimensional diffusion can provide a means for DNA-bound proteinases to locate and process DNA-bound substrates. Here, we show that this is correct. In vitro, AVP-pVIc complexes processed a purified virion precursor protein in a DNA-dependent reaction; in a quasi in vivo environment, heat-disrupted ts-1 virions, AVP-pVIc complexes processed five different precursor proteins in DNA-dependent reactions. Sliding of AVP-pVIc complexes along DNA illustrates a new biochemical mechanism by which a proteinase can locate its substrates, represents a new paradigm for virion maturation, and reveals a new way of exploiting the surface of DNA. PMID:23043138

Jitter Reduces Response-Time Variability in ADHD: An Ex-Gaussian Analysis.

PubMed

Lee, Ryan W Y; Jacobson, Lisa A; Pritchard, Alison E; Ryan, Matthew S; Yu, Qilu; Denckla, Martha B; Mostofsky, Stewart; Mahone, E Mark

2015-09-01

"Jitter" involves randomization of intervals between stimulus events. Compared with controls, individuals with ADHD demonstrate greater intrasubject variability (ISV) performing tasks with fixed interstimulus intervals (ISIs). Because Gaussian curves mask the effect of extremely slow or fast response times (RTs), ex-Gaussian approaches have been applied to study ISV. This study applied ex-Gaussian analysis to examine the effects of jitter on RT variability in children with and without ADHD. A total of 75 children, aged 9 to 14 years (44 ADHD, 31 controls), completed a go/no-go test with two conditions: fixed ISI and jittered ISI. ADHD children showed greater variability, driven by elevations in exponential (tau), but not normal (sigma) components of the RT distribution. Jitter decreased tau in ADHD to levels not statistically different than controls, reducing lapses in performance characteristic of impaired response control. Jitter may provide a nonpharmacologic mechanism to facilitate readiness to respond and reduce lapses from sustained (controlled) performance. © 2012 SAGE Publications.

Experimental evidence for superionic water ice using shock compression

NASA Astrophysics Data System (ADS)

Millot, Marius; Hamel, Sebastien; Rygg, J. Ryan; Celliers, Peter M.; Collins, Gilbert W.; Coppari, Federica; Fratanduono, Dayne E.; Jeanloz, Raymond; Swift, Damian C.; Eggert, Jon H.

2018-03-01

In stark contrast to common ice, Ih, water ice at planetary interior conditions has been predicted to become superionic with fast-diffusing (that is, liquid-like) hydrogen ions moving within a solid lattice of oxygen. Likely to constitute a large fraction of icy giant planets, this extraordinary phase has not been observed in the laboratory. Here, we report laser-driven shock-compression experiments on water ice VII. Using time-resolved optical pyrometry and laser velocimetry measurements as well as supporting density functional theory-molecular dynamics (DFT-MD) simulations, we document the shock equation of state of H2O to unprecedented extreme conditions and unravel thermodynamic signatures showing that ice melts near 5,000 K at 190 GPa. Optical reflectivity and absorption measurements also demonstrate the low electronic conductivity of ice, which, combined with previous measurements of the total electrical conductivity under reverberating shock compression, provides experimental evidence for superionic conduction in water ice at planetary interior conditions, verifying a 30-year-old prediction.

Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells.

PubMed

Nordlund, Henri R; Laitinen, Olli H; Uotila, Sanna T H; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S

2005-10-14

The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches.

Gene expression analysis of aquatic angiosperms podostemaceae to gain insight into the evolution of their enigmatic morphology.

PubMed

Koi, Satoshi; Katayama, Natsu

2013-01-01

Podostemaceae is a family of aquatic angiosperms growing submerged on rocks in fast-flowing water and called moss-like or alga-like riverweeds. It evolved remarkable innovations to adapt to such an extreme environment, one of which is reduced shoots borne on roots adhering to rock surface. Recent observations revealed that the basal subfamily Tristichoideae, like most other angiosperms, has typical shoot apical meristems (SAMs). In species of the subfamily Podostemoideae, however, shoot apical meristems (SAMs) are not formed during development and new leaves arise from the meristematic basal region of preexisting leaves. The genetic basis of this shoot organogenesis process, e.g., the expression patterns of genes homologous to transcription factors regulating shoot development, is essential to better understand the evolution of Podostemaceae. A gene expression analysis found that the SAM-less Podostemoideae leaf has mixed identity of SAM and leaf, and provided insight into the evolution of the shoot in Podostemaceae.

Data-driven magnetohydrodynamic modelling of a flux-emerging active region leading to solar eruption

PubMed Central

Jiang, Chaowei; Wu, S. T.; Feng, Xuesheng; Hu, Qiang

2016-01-01

Solar eruptions are well-recognized as major drivers of space weather but what causes them remains an open question. Here we show how an eruption is initiated in a non-potential magnetic flux-emerging region using magnetohydrodynamic modelling driven directly by solar magnetograms. Our model simulates the coronal magnetic field following a long-duration quasi-static evolution to its fast eruption. The field morphology resembles a set of extreme ultraviolet images for the whole process. Study of the magnetic field suggests that in this event, the key transition from the pre-eruptive to eruptive state is due to the establishment of a positive feedback between the upward expansion of internal stressed magnetic arcades of new emergence and an external magnetic reconnection which triggers the eruption. Such a nearly realistic simulation of a solar eruption from origin to onset can provide important insight into its cause, and also has the potential for improving space weather modelling. PMID:27181846

Longitudinal excitations in Mg-Al-O refractory oxide melts studied by inelastic x-ray scattering.

PubMed

Pozdnyakova, I; Hennet, L; Brun, J-F; Zanghi, D; Brassamin, S; Cristiglio, V; Price, D L; Albergamo, F; Bytchkov, A; Jahn, S; Saboungi, M-L

2007-03-21

The dynamic structure factor S(Q,omega) of the refractory oxide melts MgAl2O4 and MgAl4O7 is studied by inelastic x-ray scattering with aerodynamic levitation and laser heating. This technique allows the authors to measure simultaneously the elastic response and transport properties of melts under extreme temperatures. Over the wave vector Q range of 1-8 nm-1 the data can be fitted with a generalized hydrodynamic model that incorporates a slow component described by a single relaxation time and an effectively instantaneous fast component. Their study provides estimates of high-frequency sound velocities and viscosities of the Mg-Al-O melts. In contrast to liquid metals, the dispersion of the high-frequency sound mode is found to be linear, and the generalized viscosity to be Q independent. Both experiment and simulation show a weak viscosity maximum around the MgAl4O7 composition.

Longitudinal excitations in Mg-Al-O refractory oxide melts studied by inelastic x-ray scattering

NASA Astrophysics Data System (ADS)

Pozdnyakova, I.; Hennet, L.; Brun, J.-F.; Zanghi, D.; Brassamin, S.; Cristiglio, V.; Price, D. L.; Albergamo, F.; Bytchkov, A.; Jahn, S.; Saboungi, M.-L.

2007-03-01

The dynamic structure factor S(Q,ω) of the refractory oxide melts MgAl2O4 and MgAl4O7 is studied by inelastic x-ray scattering with aerodynamic levitation and laser heating. This technique allows the authors to measure simultaneously the elastic response and transport properties of melts under extreme temperatures. Over the wave vector Q range of 1-8nm-1 the data can be fitted with a generalized hydrodynamic model that incorporates a slow component described by a single relaxation time and an effectively instantaneous fast component. Their study provides estimates of high-frequency sound velocities and viscosities of the Mg-Al-O melts. In contrast to liquid metals, the dispersion of the high-frequency sound mode is found to be linear, and the generalized viscosity to be Q independent. Both experiment and simulation show a weak viscosity maximum around the MgAl4O7 composition.

Patients' perspectives of fast-track surgery and the role of the fast-track clinical nurse consultant in gynecological oncology.

PubMed

Philp, Shannon; Carter, J; Barnett, C; DʼAbrew, N; Pather, S; White, K

2015-01-01

This study examines the role of the fast-track nurse in gynecology from a patient perspective. The fast-track nurse is a specialist nursing role, which coordinates patient care, in addition to providing specialized clinical care. Semistructured interviews were conducted with women who had fast-track surgery for gynecological cancer.

Data management software concept for WEST plasma measurement system

NASA Astrophysics Data System (ADS)

Zienkiewicz, P.; Kasprowicz, G.; Byszuk, A.; Wojeński, A.; Kolasinski, P.; Cieszewski, R.; Czarski, T.; Chernyshova, M.; Pozniak, K.; Zabolotny, W.; Juszczyk, B.; Mazon, D.; Malard, P.

2014-11-01

This paper describes the concept of data management software for the multichannel readout system for the GEM detector used in WEST Plasma experiment. The proposed system consists of three separate communication channels: fast data channel, diagnostics channel, slow data channel. Fast data channel is provided by the FPGA with integrated ARM cores providing direct readout data from Analog Front Ends through 10GbE with short, guaranteed intervals. Slow data channel is provided by multiple, fast CPUs after data processing with detailed readout data with use of GNU/Linux OS and appropriate software. Diagnostic channel provides detailed feedback for control purposes.

Heterogeneous Sensitivity of Tropical Precipitation Extremes during Growth and Mature Phases of Atmospheric Warming

NASA Astrophysics Data System (ADS)

Parhi, P.; Giannini, A.; Lall, U.; Gentine, P.

2016-12-01

Assessing and managing risks posed by climate variability and change is challenging in the tropics, from both a socio-economic and a scientific perspective. Most of the vulnerable countries with a limited climate adaptation capability are in the tropics. However, climate projections, particularly of extreme precipitation, are highly uncertain there. The CMIP5 (Coupled Model Inter- comparison Project - Phase 5) inter-model range of extreme precipitation sensitivity to the global temperature under climate change is much larger in the tropics as compared to the extra-tropics. It ranges from nearly 0% to greater than 30% across models (O'Gorman 2012). The uncertainty is also large in historical gauge or satellite based observational records. These large uncertainties in the sensitivity of tropical precipitation extremes highlight the need to better understand how tropical precipitation extremes respond to warming. We hypothesize that one of the factors explaining the large uncertainty is due to differing sensitivities during different phases of warming. We consider the `growth' and `mature' phases of warming under climate variability case- typically associated with an El Niño event. In the remote tropics (away from tropical Pacific Ocean), the response of the precipitation extremes during the two phases can be through different pathways: i) a direct and fast changing radiative forcing in an atmospheric column, acting top-down due to the tropospheric warming, and/or ii) an indirect effect via changes in surface temperatures, acting bottom-up through surface water and energy fluxes. We also speculate that the insights gained here might be useful in interpreting the large sensitivity under climate change scenarios, since the physical mechanisms during the two warming phases under climate variability case, have some correspondence with an increasing and stabilized green house gas emission scenarios.

Interactivity vs. fairness in networked linux systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Wenji; Crawford, Matt; /Fermilab

In general, the Linux 2.6 scheduler can ensure fairness and provide excellent interactive performance at the same time. However, our experiments and mathematical analysis have shown that the current Linux interactivity mechanism tends to incorrectly categorize non-interactive network applications as interactive, which can lead to serious fairness or starvation issues. In the extreme, a single process can unjustifiably obtain up to 95% of the CPU! The root cause is due to the facts that: (1) network packets arrive at the receiver independently and discretely, and the 'relatively fast' non-interactive network process might frequently sleep to wait for packet arrival. Thoughmore » each sleep lasts for a very short period of time, the wait-for-packet sleeps occur so frequently that they lead to interactive status for the process. (2) The current Linux interactivity mechanism provides the possibility that a non-interactive network process could receive a high CPU share, and at the same time be incorrectly categorized as 'interactive.' In this paper, we propose and test a possible solution to address the interactivity vs. fairness problems. Experiment results have proved the effectiveness of the proposed solution.« less

Recent advances in modeling and simulation of the exposure and response of tungsten to fusion energy conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marian, Jaime; Becquart, Charlotte S.; Domain, Christophe

2017-06-09

Under the anticipated operating conditions for demonstration magnetic fusion reactors beyond ITER, structural materials will be exposed to unprecedented conditions of irradiation, heat flux, and temperature. While such extreme environments remain inaccessible experimentally, computational modeling and simulation can provide qualitative and quantitative insights into materials response and complement the available experimental measurements with carefully validated predictions. For plasma facing components such as the first wall and the divertor, tungsten (W) has been selected as the best candidate material due to its superior high-temperature and irradiation properties. In this paper we provide a review of recent efforts in computational modeling ofmore » W both as a plasma-facing material exposed to He deposition as well as a bulk structural material subjected to fast neutron irradiation. We use a multiscale modeling approach –commonly used as the materials modeling paradigm– to define the outline of the paper and highlight recent advances using several classes of techniques and their interconnection. We highlight several of the most salient findings obtained via computational modeling and point out a number of remaining challenges and future research directions« less

[Osmotic demyelination syndrome in Addison crisis and severe hyponatremia].

PubMed

Andersen, Signe Elisabeth Bødker; Stausbøl-Grøn, Brian; Rasmussen, Torsten Bloch

2008-12-08

Acute adrenal insufficiency is a life threatening disease with dehydration, hypotension, cerebral dysfunction and gastrointestinal symptoms accompanied by low plasma sodium and high plasma potassium. Osmotic demyelination syndrome (ODS) can occur rarely following correction of plasma sodium. We describe a case with extremely low plasma sodium and subsequent development of ODS. Correction which is too slow may lead to cerebral oedema, brain stem herniation and low sodium encephalopathy. Correction which is too fast may cause ODS. The dilemma is accentuated by concomitant Addison crisis.

Sustained transdermal release of diltiazem hydrochloride through electron beam irradiated different PVA hydrogel membranes

NASA Astrophysics Data System (ADS)

Bhunia, Tridib; Goswami, Luna; Chattopadhyay, Dipankar; Bandyopadhyay, Abhijit

2011-08-01

Extremely fast release of diltiazem hydrochloride (water soluble, anti anginal drug used to treat chest pain) together with its faster erosion has been the primary problem in conventional oral therapy. It has been addressed in this paper by encapsulating the drug in electron beam irradiated various poly (vinyl alcohol) hydrogel membranes and delivering it through transdermal route. Results show excellent control over the release of diltiazem hydrochloride through these membranes subject to their physico-mechanicals.

Extreme energy cosmic rays (EECR) observation capabilities of an "Airwatch from Space" mission.

NASA Astrophysics Data System (ADS)

de Marzo, C. N.

1999-01-01

The longitudinal development and other characteristics of the EECR induced atmospheric showers can be studied from space by detecting the fluorescence light induced in the atmospheric nitrogen. According to the Airwatch concept a single fast detector can be used for measuring both intensity and time development of the streak of fluorescence light produced by the atmospheric shower induced by an EECR. In the present communication the detection capabilities for the EECR observation from space are discussed.

Extremely Fast Numerical Integration of Ocean Surface Wave Dynamics: Building Blocks for a Higher Order Method

DTIC Science & Technology

2006-09-30

equation known as the Kadomtsev - Petviashvili (KP) equation ): (ηt + coηx +αηηx + βη )x +γηyy = 0 (4) where γ = co / 2 . The KdV equation ...using the spectral formulation of the Kadomtsev - Petviashvili equation , a standard equation for nonlinear, shallow water wave dynamics that is a... Petviashvili and nonlinear Schroedinger equations and higher order corrections have been developed as prerequisites to coding the Boussinesq and Euler

Analysis of the Suspended H-Waveguide and Other Related Dielectric Waveguide Structures.

DTIC Science & Technology

1983-01-01

energy is concentrated in the disc. In the substrate regions, the fields decay extremely fast. Consequently, the removal of the dielectric substrates...ado re erse ide i f ne oeeary e d IdO tif’ I V Week 110m mke ) 0 In this thesis, the field and propagation characceristicshof’many dielectric waveguide...propagation co*stants and the field distribu- tions of a newly developed suspended H-woveguide based on the mode matching techniques is described. The d

Matrix-Free Polynomial-Based Nonlinear Least Squares Optimized Preconditioning and its Application to Discontinuous Galerkin Discretizations of the Euler Equations

DTIC Science & Technology

2015-06-01

cient parallel code for applying the operator. Our method constructs a polynomial preconditioner using a nonlinear least squares (NLLS) algorithm. We show...apply the underlying operator. Such a preconditioner can be very attractive in scenarios where one has a highly efficient parallel code for applying...repeatedly solve a large system of linear equations where one has an extremely fast parallel code for applying an underlying fixed linear operator

Preliminary In Vitro Evaluation of an Adjunctive Therapy for Extremity Wound Infection Reduction: Rapidly Resorbing Local Antibiotic Delivery

DTIC Science & Technology

2009-07-01

activity of fast- degrading drug delivery vehicles made from cellulose binder and calcium sulfate dihydrate and from conven- tional calcium sulfate...investigations are planned to deter- mine if the in vitro findings of this study correlate to reduced risk of infection, biofilm formation, patient...of bacteria in biofilms . Lancet 358:135–138. 31. Donlan RM. 2002. Biofilms : microbial life on surfaces. Emerg Infect Dis 8:881–890. 32. Sarkisova S

Mercury- Distributed Metadata Management, Data Discovery and Access System

NASA Astrophysics Data System (ADS)

Palanisamy, Giri; Wilson, Bruce E.; Devarakonda, Ranjeet; Green, James M.

2007-12-01

Mercury is a federated metadata harvesting, search and retrieval tool based on both open source and ORNL- developed software. It was originally developed for NASA, and the Mercury development consortium now includes funding from NASA, USGS, and DOE. Mercury supports various metadata standards including XML, Z39.50, FGDC, Dublin-Core, Darwin-Core, EML, and ISO-19115 (under development). Mercury provides a single portal to information contained in disparate data management systems. It collects metadata and key data from contributing project servers distributed around the world and builds a centralized index. The Mercury search interfaces then allow the users to perform simple, fielded, spatial and temporal searches across these metadata sources. This centralized repository of metadata with distributed data sources provides extremely fast search results to the user, while allowing data providers to advertise the availability of their data and maintain complete control and ownership of that data. Mercury supports various projects including: ORNL DAAC, NBII, DADDI, LBA, NARSTO, CDIAC, OCEAN, I3N, IAI, ESIP and ARM. The new Mercury system is based on a Service Oriented Architecture and supports various services such as Thesaurus Service, Gazetteer Web Service and UDDI Directory Services. This system also provides various search services including: RSS, Geo-RSS, OpenSearch, Web Services and Portlets. Other features include: Filtering and dynamic sorting of search results, book-markable search results, save, retrieve, and modify search criteria.

76 FR 20679 - Agency Information Collection Activities; Proposed Collection; Comment Request; Guidance for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

...: Fast Track Drug Development Programs: Designation, Development, and Application Review AGENCY: Food and... licenses for fast track designation as provided in the guidance for industry on fast track drug development... appropriate, and other forms of information technology. Guidance for Industry: Fast Track Drug Development...

Review of Transient Testing of Fast Reactor Fuels in the Transient REActor Test Facility (TREAT)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, C.; Wachs, D.; Carmack, J.

The restart of the Transient REActor Test (TREAT) facility provides a unique opportunity to engage the fast reactor fuels community to reinitiate in-pile experimental safety studies. Historically, the TREAT facility played a critical role in characterizing the behavior of both metal and oxide fast reactor fuels under off-normal conditions, irradiating hundreds of fuel pins to support fast reactor fuel development programs. The resulting test data has provided validation for a multitude of fuel performance and severe accident analysis computer codes. This paper will provide a review of the historical database of TREAT experiments including experiment design, instrumentation, test objectives, andmore » salient findings. Additionally, the paper will provide an introduction to the current and future experiment plans of the U.S. transient testing program at TREAT.« less

Disaster response team FAST skills training with a portable ultrasound simulator compared to traditional training: pilot study.

PubMed

Paddock, Michael T; Bailitz, John; Horowitz, Russ; Khishfe, Basem; Cosby, Karen; Sergel, Michelle J

2015-03-01

Pre-hospital focused assessment with sonography in trauma (FAST) has been effectively used to improve patient care in multiple mass casualty events throughout the world. Although requisite FAST knowledge may now be learned remotely by disaster response team members, traditional live instructor and model hands-on FAST skills training remains logistically challenging. The objective of this pilot study was to compare the effectiveness of a novel portable ultrasound (US) simulator with traditional FAST skills training for a deployed mixed provider disaster response team. We randomized participants into one of three training groups stratified by provider role: Group A. Traditional Skills Training, Group B. US Simulator Skills Training, and Group C. Traditional Skills Training Plus US Simulator Skills Training. After skills training, we measured participants' FAST image acquisition and interpretation skills using a standardized direct observation tool (SDOT) with healthy models and review of FAST patient images. Pre- and post-course US and FAST knowledge were also assessed using a previously validated multiple-choice evaluation. We used the ANOVA procedure to determine the statistical significance of differences between the means of each group's skills scores. Paired sample t-tests were used to determine the statistical significance of pre- and post-course mean knowledge scores within groups. We enrolled 36 participants, 12 randomized to each training group. Randomization resulted in similar distribution of participants between training groups with respect to provider role, age, sex, and prior US training. For the FAST SDOT image acquisition and interpretation mean skills scores, there was no statistically significant difference between training groups. For US and FAST mean knowledge scores, there was a statistically significant improvement between pre- and post-course scores within each group, but again there was not a statistically significant difference between training groups. This pilot study of a deployed mixed-provider disaster response team suggests that a novel portable US simulator may provide equivalent skills training in comparison to traditional live instructor and model training. Further studies with a larger sample size and other measures of short- and long-term clinical performance are warranted.

Fast sensory–motor reactions in echolocating bats to sudden changes during the final buzz and prey intercept

PubMed Central

Geberl, Cornelia; Brinkløv, Signe; Wiegrebe, Lutz; Surlykke, Annemarie

2015-01-01

Echolocation is an active sense enabling bats and toothed whales to orient in darkness through echo returns from their ultrasonic signals. Immediately before prey capture, both bats and whales emit a buzz with such high emission rates (≥180 Hz) and overall duration so short that its functional significance remains an enigma. To investigate sensory–motor control during the buzz of the insectivorous bat Myotis daubentonii, we removed prey, suspended in air or on water, before expected capture. The bats responded by shortening their echolocation buzz gradually; the earlier prey was removed down to approximately 100 ms (30 cm) before expected capture, after which the full buzz sequence was emitted both in air and over water. Bats trawling over water also performed the full capture behavior, but in-air capture motions were aborted, even at very late prey removals (<20 ms = 6 cm before expected contact). Thus, neither the buzz nor capture movements are stereotypical, but dynamically adapted based on sensory feedback. The results indicate that echolocation is controlled mainly by acoustic feedback, whereas capture movements are adjusted according to both acoustic and somatosensory feedback, suggesting separate (but coordinated) central motor control of the two behaviors based on multimodal input. Bat echolocation, especially the terminal buzz, provides a unique window to extremely fast decision processes in response to sensory feedback and modulation through attention in a naturally behaving animal. PMID:25775538

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Yang; Piper, Daniela M.; Gu, Meng

Surface modification of silicon nanoparticle via molecular layer deposition (MLD) has been recently proved to be an effective way for dramatically enhancing the cyclic performance in lithium ion batteries. However, the fundamental mechanism as how this thin layer of coating function is not known, which is even complicated by the inevitable presence of native oxide of several nanometers on the silicon nanoparticle. Using in-situ TEM, we probed in detail the structural and chemical evolution of both uncoated and coated silicon particles upon cyclic lithiation/delithation. We discovered that upon initial lithiation, the native oxide layer converts to crystalline Li2O islands, whichmore » essentially increases the impedance on the particle, resulting in ineffective lithiation/delithiation, and therefore low coulombic efficiency. In contrast, the alucone MLD coated particles show extremely fast, thorough and highly reversible lithiation behaviors, which are clarified to be associated with the mechanical flexibility and fast Li+/e- conductivity of the alucone coating. Surprisingly, the alucone MLD coating process chemically changes the silicon surface, essentially removing the native oxide layer and therefore mitigates side reaction and detrimental effects of the native oxide. This study provides a vivid picture of how the MLD coating works to enhance the coulombic efficiency and preserve capacity and clarifies the role of the native oxide on silicon nanoparticles during cyclic lithiation and delithiation. More broadly, this work also demonstrated that the effect of the subtle chemical modification of the surface during the coating process may be of equal importance as the coating layer itself.« less

Standoff detection: classification of biological aerosols using laser induced fluorescence (LIF) technique

NASA Astrophysics Data System (ADS)

Hausmann, Anita; Duschek, Frank; Fischbach, Thomas; Pargmann, Carsten; Aleksejev, Valeri; Poryvkina, Larisa; Sobolev, Innokenti; Babichenko, Sergey; Handke, Jürgen

2014-05-01

The challenges of detecting hazardous biological materials are manifold: Such material has to be discriminated from other substances in various natural surroundings. The detection sensitivity should be extremely high. As living material may reproduce itself, already one single bacterium may represent a high risk. Of course, identification should be quite fast with a low false alarm rate. Up to now, there is no single technique to solve this problem. Point sensors may collect material and identify it, but the problems of fast identification and especially of appropriate positioning of local collectors are sophisticated. On the other hand, laser based standoff detection may instantaneously provide the information of some accidental spillage of material by detecting the generated thin cloud. LIF technique may classify but hardly identify the substance. A solution can be the use of LIF technique in a first step to collect primary data and - if necessary- followed by utilizing these data for an optimized positioning of point sensors. We perform studies on an open air laser test range at distances between 20 and 135 m applying LIF technique to detect and classify aerosols. In order to employ LIF capability, we use a laser source emitting two wavelengths alternatively, 280 and 355 nm, respectively. Moreover, the time dependence of fluorescence spectra is recorded by a gated intensified CCD camera. Signal processing is performed by dedicated software for spectral pattern recognition. The direct comparison of all results leads to a basic classification of the various compounds.

Near Real Time Flood Warning System for National Capital Territory of Delhi

NASA Astrophysics Data System (ADS)

Goyal, A.; Yadav, H.; Tyagi, H.; Gosain, A. K.

2017-12-01

Extreme floods are common phenomena during Indian Monsoons. The National Capital Territory area of India, Delhi, frequently experiences fluvial as well as pluvial inundation due to its proximity to river Yamuna and poor functioning of its stormwater drainage system. The urban floods result in severe waterlogging and heavy traffic snarls, bringing life in this megapolis to a halt. The city has witnessed six major floods since 1900 and thus its residents are well conscious of potential flood risks but the city still lacks a flood warning system. The flood related risks can be considerably reduced, if not eliminated, by issuing timely warnings and implementing adaptive measures. Therefore, the present study attempts to develop a web based platform that integrates Web-GIS technology and mathematical simulation modelling to provide an effective and reliable early flood warning service for Delhi. The study makes use of India Metorological Department's Doppler radar-derived near real time rainfall estimates of 15 minutes time step. The developed SWMM model has been validated using information from gauges, monitoring sensors and crowd sourcing techniques and utilises capabilities of cloud computing on server side for fast processing. This study also recommends safe evacuation policy and remedial measures for flooding hotspots as part of flood risk management plan. With heightened risk of floods in fast urbanizing areas, this work becomes highly pertinent as flood warning system with adequate lead time can not only save precious lives but can also substantially reduce flood damages.

Prospective Player-Reported Injuries in Female Youth Fast-Pitch Softball Players

PubMed Central

Smith, Matthew V.; Davis, Randi; Brophy, Robert H.; Prather, Heidi; Garbutt, Jane; Wright, Rick W.

2015-01-01

Background: There is a scarcity of literature evaluating injuries in youth fast-pitch softball players. Purpose: To perform a descriptive analysis of player-reported injuries in youth fast-pitch softball position players and pitchers during a single select-level season. Study Design: Prospective observation cohort study. Level of Evidence: Level 3. Methods: Ninety-eight athletes (48 pitchers, 50 position players) were followed for a single select fast-pitch softball season. Study participants completed web-based surveys every 3 weeks reporting injuries related to participation in fast-pitch softball. Injury was defined as pain causing cessation of participation in the current game or practice that prevents the player’s return to that session or any pain that causes cessation of a player’s customary participation on the day after the day of onset. Results: The median age of the study participants was 14 years (range, 9-18 years). There were 49 reported injuries in 98 athletes. The average age was 13 years for those not injured and 14 years for those who were injured (P < 0.02). There were 31 injuries that were not related to pitching: 19 occurred in position players and 12 occurred in pitchers; 70% of these injuries were to the lower extremity. The proportion of injuries not related to pitching was significantly greater than the proportion of injuries related to pitching (P < 0.02). Eighteen injuries among the 48 pitchers (38%) were directly attributed to pitching. Among the 18 pitching injuries, 11 (61%) involved the shoulder. The majority (78%) of injuries related to pitching occurred in the first 6 weeks of the season. Conclusion: There was a high incidence of injury in this prospective cohort of youth select-level fast-pitch softball players. Better off-season and preseason conditioning may be a key factor for reducing pitching injuries. Clinical Relevance: Recognition of injury patterns in fast-pitch softball players is critical to developing strategies to keep these athletes competing safely. PMID:26502442

Prospective Player-Reported Injuries in Female Youth Fast-Pitch Softball Players.

PubMed

Smith, Matthew V; Davis, Randi; Brophy, Robert H; Prather, Heidi; Garbutt, Jane; Wright, Rick W

2015-01-01

There is a scarcity of literature evaluating injuries in youth fast-pitch softball players. To perform a descriptive analysis of player-reported injuries in youth fast-pitch softball position players and pitchers during a single select-level season. Prospective observation cohort study. Level 3. Ninety-eight athletes (48 pitchers, 50 position players) were followed for a single select fast-pitch softball season. Study participants completed web-based surveys every 3 weeks reporting injuries related to participation in fast-pitch softball. Injury was defined as pain causing cessation of participation in the current game or practice that prevents the player's return to that session or any pain that causes cessation of a player's customary participation on the day after the day of onset. The median age of the study participants was 14 years (range, 9-18 years). There were 49 reported injuries in 98 athletes. The average age was 13 years for those not injured and 14 years for those who were injured (P < 0.02). There were 31 injuries that were not related to pitching: 19 occurred in position players and 12 occurred in pitchers; 70% of these injuries were to the lower extremity. The proportion of injuries not related to pitching was significantly greater than the proportion of injuries related to pitching (P < 0.02). Eighteen injuries among the 48 pitchers (38%) were directly attributed to pitching. Among the 18 pitching injuries, 11 (61%) involved the shoulder. The majority (78%) of injuries related to pitching occurred in the first 6 weeks of the season. There was a high incidence of injury in this prospective cohort of youth select-level fast-pitch softball players. Better off-season and preseason conditioning may be a key factor for reducing pitching injuries. Recognition of injury patterns in fast-pitch softball players is critical to developing strategies to keep these athletes competing safely. © 2015 The Author(s).

Preoperative fasting: knowledge and perceptions.

PubMed

Baril, Patrice; Portman, Harriet

2007-10-01

Preoperative patient fasting is an essential element of the patient preparation process, but patients may be fasting for excessive lengths of time. Investigators at one facility used semi-structured interviews to explore the knowledge and beliefs of patients, nurses, and anesthesia care providers regarding the practice of preoperative patient fasting. Findings indicate that some patients had excessive fasting times, and practitioners had erroneous perceptions about patient knowledge regarding the rationale for fasting and compliance with instructions. Clinicians expressed concern about the effects of excessive fasting but were reluctant to relax the policy.

An Anticipatory Model of Cavitation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allgood, G.O.; Dress, W.B., Jr.; Hylton, J.O.

1999-04-05

The Anticipatory System (AS) formalism developed by Robert Rosen provides some insight into the problem of embedding intelligent behavior in machines. AS emulates the anticipatory behavior of biological systems. AS bases its behavior on its expectations about the near future and those expectations are modified as the system gains experience. The expectation is based on an internal model that is drawn from an appeal to physical reality. To be adaptive, the model must be able to update itself. To be practical, the model must run faster than real-time. The need for a physical model and the requirement that the modelmore » execute at extreme speeds, has held back the application of AS to practical problems. Two recent advances make it possible to consider the use of AS for practical intelligent sensors. First, advances in transducer technology make it possible to obtain previously unavailable data from which a model can be derived. For example, acoustic emissions (AE) can be fed into a Bayesian system identifier that enables the separation of a weak characterizing signal, such as the signature of pump cavitation precursors, from a strong masking signal, such as a pump vibration feature. The second advance is the development of extremely fast, but inexpensive, digital signal processing hardware on which it is possible to run an adaptive Bayesian-derived model faster than real-time. This paper reports the investigation of an AS using a model of cavitation based on hydrodynamic principles and Bayesian analysis of data from high-performance AE sensors.« less

Determination of astrophysical parameters of quasars within the Gaia mission

NASA Astrophysics Data System (ADS)

Delchambre, L.

2018-01-01

We describe methods designed to determine the astrophysical parameters of quasars based on spectra coming from the red and blue spectrophotometers of the Gaia satellite. These methods principally rely on two already published algorithms that are the weighted principal component analysis and the weighted phase correlation. The presented approach benefits from a fast implementation, an intuitive interpretation as well as strong diagnostic tools on the potential errors that may arise during predictions. The production of a semi-empirical library of spectra as they will be observed by Gaia is also covered and subsequently used for validation purpose. We detail the pre-processing that is necessary in order for these spectra to be fully exploitable by our algorithms along with the procedures that are used to predict the redshifts of the quasars, their continuum slopes, the total equivalent width of their emission lines and whether these are broad absorption line (BAL) quasars or not. Performances of these procedures were assessed in comparison with the extremely randomized trees learning method and were proven to provide better results on the redshift predictions and on the ratio of correctly classified observations though the probability of detection of BAL quasars remains restricted by the low resolution of these spectra as well as by their limited signal-to-noise ratio. Finally, the triggering of some warning flags allows us to obtain an extremely pure subset of redshift predictions where approximately 99 per cent of the observations come along with absolute errors that are below 0.1.

Funding of community-based interventions for HIV prevention.

PubMed

Poku, Nana K; Bonnel, René

2016-07-01

Since the start of the HIV epidemic, community responses have been at the forefront of the response. Following the extraordinary expansion of global resources, the funding of community responses rose to reach at least US$690 million per year in the period 2005-2009. Since then, many civil society organisations (CSOs) have reported a drop in funding. Yet, the need for strong community responses is even more urgent, as shown by their role in reaching the Joint United Nations Programme on HIV/AIDS (UNAIDS) Fast-Track targets. In the case of antiretroviral treatment, interventions need to be adopted by most people at risk of HIV in order to have a substantial effect on the prevention of HIV at the population level. This paper reviews the published literature on community responses, funding and effectiveness. Additional funding is certainly needed to increase the coverage of community-based interventions (CBIs), but current evidence on their effectiveness is extremely mixed, which does not provide clear guidance to policy makers. This is especially an issue for adolescent girls and young women in Eastern and Southern Africa, who face extremely high infection risk, but the biomedical prevention tools that have been proven effective for the general population still remain pilot projects for this group. Research is especially needed to isolate the factors affecting the likelihood that interventions targeting this group are consistently successful. Such work could be focused on the community organisations that are currently involved in delivering gender-sensitive interventions.

The effect of social integration on outcomes after major lower extremity amputation.

PubMed

Hawkins, Alexander T; Pallangyo, Anthony J; Herman, Ayesiga M; Schaumeier, Maria J; Smith, Ann D; Hevelone, Nathanael D; Crandell, David M; Nguyen, Louis L

2016-01-01

Major lower extremity (MLE) amputation is a common procedure that results in a profound change in a patient's life. We sought to determine the association between social support and outcomes after amputation. We hypothesized that patients with greater social support will have better post amputation outcomes. From November 2011 to May 2013, we conducted a cross-sectional, observational, multicenter study. Social integration was measured by the social integration subset of the Short Form Craig Handicap Assessment and Reporting Technique. Systemic social support was assessed by comparing a United States and Tanzanian population. Walking function was measured using the 6-minute walk test and quality of life (QoL) was measured using the EuroQol-5D. We recruited 102 MLE amputees. Sixty-three patients were enrolled in the United States with a mean age of 58.0. Forty-two (67%) were male. Patients with low social integration were more likely to be unable to ambulate (no walk 39% vs slow walk 23% vs fast walk 10%; P = .01) and those with high social integration were more likely to be fast walkers (no walk 10% vs slow walk 59% vs fast walk 74%; P = .01). This relationship persisted in a multivariable analysis. Increasing social integration scores were also positively associated with increasing QoL scores in a multivariable analysis (β, .002; standard error, 0.0008; P = .02). In comparing the United States population with the Tanzanian cohort (39 subjects), there were no differences between functional or QoL outcomes in the systemic social support analysis. In the United States population, increased social integration is associated with both improved function and QoL outcomes among MLE amputees. Systemic social support, as measured by comparing the United States population with a Tanzanian population, was not associated with improved function or QoL outcomes. In the United States, steps should be taken to identify and aid amputees with poor social integration. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry as a tool for fast identification of protein binders in color layers of paintings.

PubMed

Hynek, Radovan; Kuckova, Stepanka; Hradilova, Janka; Kodicek, Milan

2004-01-01

Identification of materials in color layers of paintings is necessary for correct decisions concerning restoration procedures as well as proving the authenticity of the painting. The proteins are usually important components of the painting layers. In this paper it has been demonstrated that matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) can be used for fast and reliable identification of proteins in color layers even in old, highly aged matrices. The digestion can be easily performed directly on silica wafers which are routinely used for infrared analysis. The amount of material necessary for such an analysis is extremely small. Peptide mass mapping using digestion with trypsin followed by MALDI-TOFMS and identification of the protein was successfully used for determination of the binder from a painting of the 19th century. Copyright 2004 John Wiley & Sons, Ltd.

A Fast-Evolving, Luminous Transient Discovered by K2/Kepler

NASA Astrophysics Data System (ADS)

Rest, Armin; Garnavich, Peter; Khatami, David; Kasen, Daniel; Tucker, Brad; Shaya, Edward; Olling, Robert; Mushotzky, Richard; Zenteno, Alfredo; Margheim, Steven; Strampelli, Giovanni Maria; James, David; Smith, Chris; Forster, Francisco; Villar, Ashley

2018-01-01

For decades optical time-domain searches have been tuned to find ordinary supernovae, which rise and fall in brightness over a period of weeks. Recently, supernova searches have improved their cadences and a handful of fast-evolving luminous transients (FELTs) have been identified. FELTs have peak luminosities comparable to type Ia supernovae, but rise to maximum in <10 days and fade from view in <30 days. Here we present the most extreme example of this class thus far, KSN2015K, with a rise time of only 2.2 days and a time above half-maximum of only 6.8 days. Possible energy sources for KSN2015K are the decay of radioactive elements, a central engine powered by accretion/magnetic fields, or hydrodynamic shock. We show that KSN2015K's luminosity makes it unlikely to be powered by radioactive isotopes, and we find that the shock breakout into a dense wind most likely energized the transient.

The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey

NASA Astrophysics Data System (ADS)

Bannister, K. W.; Shannon, R. M.; Macquart, J.-P.; Flynn, C.; Edwards, P. G.; O'Neill, M.; Osłowski, S.; Bailes, M.; Zackay, B.; Clarke, N.; D'Addario, L. R.; Dodson, R.; Hall, P. J.; Jameson, A.; Jones, D.; Navarro, R.; Trinh, J. T.; Allison, J.; Anderson, C. S.; Bell, M.; Chippendale, A. P.; Collier, J. D.; Heald, G.; Heywood, I.; Hotan, A. W.; Lee-Waddell, K.; Madrid, J. P.; Marvil, J.; McConnell, D.; Popping, A.; Voronkov, M. A.; Whiting, M. T.; Allen, G. R.; Bock, D. C.-J.; Brodrick, D. P.; Cooray, F.; DeBoer, D. R.; Diamond, P. J.; Ekers, R.; Gough, R. G.; Hampson, G. A.; Harvey-Smith, L.; Hay, S. G.; Hayman, D. B.; Jackson, C. A.; Johnston, S.; Koribalski, B. S.; McClure-Griffiths, N. M.; Mirtschin, P.; Ng, A.; Norris, R. P.; Pearce, S. E.; Phillips, C. J.; Roxby, D. N.; Troup, E. R.; Westmeier, T.

2017-05-01

We report the detection of an ultra-bright fast radio burst (FRB) from a modest, 3.4-day pilot survey with the Australian Square Kilometre Array Pathfinder. The survey was conducted in a wide-field fly’s-eye configuration using the phased-array-feed technology deployed on the array to instantaneously observe an effective area of 160 deg2, and achieve an exposure totaling 13200 deg2 hr . We constrain the position of FRB 170107 to a region 8\\prime × 8\\prime in size (90% containment) and its fluence to be 58 ± 6 Jy ms. The spectrum of the burst shows a sharp cutoff above 1400 MHz, which could be due to either scintillation or an intrinsic feature of the burst. This confirms the existence of an ultra-bright (> 20 Jy ms) population of FRBs.

A Universal Organic Cathode for Ultrafast Lithium- and Multivalent Metal Batteries.

PubMed

Fan, Xiulin; Wang, Fei; Ji, Xiao; Wang, Ruixing; Gao, Tao; Hou, Singyuk; Chen, Ji; Deng, Tao; Li, Xiaogang; Chen, Long; Luo, Chao; Wang, Luning; Wang, Chunsheng

2018-04-27

Low-cost multivalent battery chemistries (Mg 2+ , Al 3+ ) have been extensively investigated for large-scale energy storage applications. However, their commercialization is plagued by the poor power density and cycle life of cathodes. A universal polyimides@CNT (PI@CNT) cathode is now presented that can reversibly store various cations with different valences (Li + , Mg 2+ , Al 3+ ) at an extremely fast rate. The ion-coordination charge storage mechanism of PI@CNT is systemically investigated. Full cells using PI@CNT cathodes and corresponding metal anodes exhibit long cycle life (>10000 cycles), fast kinetics (>20 C), and wide operating temperature range (-40 to 50 °C), making the low-cost industrial polyimides universal cathodes for different multivalent metal batteries. The stable ion-coordinated mechanism opens a new foundation for the development of high-energy and high-power multivalent batteries. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Development of Advanced Ods Ferritic Steels for Fast Reactor Fuel Cladding

NASA Astrophysics Data System (ADS)

Ukai, S.; Oono, N.; Ohtsuka, S.; Kaito, T.

Recent progress of the 9CrODS steel development is presented focusing on their microstructure control to improve sufficient high-temperature strength as well as cladding manufacturing capability. The martensitic 9CrODS steel is primarily candidate cladding materials for the Generation IV fast reactor fuel. They are the attractive composite-like materials consisting of the hard residual ferrite and soft tempered martensite, which are able to be easily controlled by α-γ phase transformation. The residual ferrite containing extremely nanosized oxide particles leads to significantly improved creep rupture strength in 9CrODS cladding. The creep strength stability at extended time of 60,000 h at 700 ºC is ascribed to the stable nanosized oxide particles. It was also reviewed that 9CrODS steel has well irradiation stability and fuel pin irradiation test was conducted up to 12 at% burnup and 51 dpa at the cladding temperature of 700ºC.

Improved Data Acquisition Methods for Uninterrupted Signal Monitoring and Ultra-Fast Plasma Diagnostics in LHD

NASA Astrophysics Data System (ADS)

Nakanishi, Hideya; Imazu, Setsuo; Ohsuna, Masaki; Kojima, Mamoru; Nonomura, Miki; Shoji, Mamoru; Emoto, Masahiko; Yoshida, Masanobu; Iwata, Chie; Miyake, Hitoshi; Nagayama, Yoshio; Kawahata, Kazuo

To deal with endless data streams acquired in LHD steady-state experiments, the LHD data acquisition system was designed with a simple concept that divides a long pulse into a consecutive series of 10-s “subshots”. Latest digitizers applying high-speed PCI-Express technology, however, output nonstop gigabyte per second data streams whose subshot intervals would be extremely long if 10-s rule was applied. These digitizers need shorter subshot intervals, less than 10-s long. In contrast, steady-state fusion plants need uninterrupted monitoring of the environment and device soundness. They adopt longer subshot lengths of either 10 min or 1 day. To cope with both uninterrupted monitoring and ultra-fast diagnostics, the ability to vary the subshot length according to the type of operation is required. In this study, a design modification that enables variable subshot lengths was implemented and its practical effectiveness in LHD was verified.

Movement decoupling control for two-axis fast steering mirror

NASA Astrophysics Data System (ADS)

Wang, Rui; Qiao, Yongming; Lv, Tao

2017-02-01

Based on flexure hinge and piezoelectric actuator of two-axis fast steering mirror is a complex system with time varying, uncertain and strong coupling. It is extremely difficult to achieve high precision decoupling control with the traditional PID control method. The feedback error learning method was established an inverse hysteresis model which was based inner product dynamic neural network nonlinear and no-smooth for piezo-ceramic. In order to improve the actuator high precision, a method was proposed, which was based piezo-ceramic inverse model of two dynamic neural network adaptive control. The experiment result indicated that, compared with two neural network adaptive movement decoupling control algorithm, static relative error is reduced from 4.44% to 0.30% and coupling degree is reduced from 12.71% to 0.60%, while dynamic relative error is reduced from 13.92% to 2.85% and coupling degree is reduced from 2.63% to 1.17%.

Muscle Strength Imbalance in the Hip Joint Caused by Fast Movements

NASA Astrophysics Data System (ADS)

Pontaga, I.

2003-07-01

Eleven male sportsmen at the age of 24.3 ± 4.5 were examined. Their hip joint flexors and extensors were tested by an "REV-9000" Technogym dynamometer system during isokinetic movements at angular velocities of 100 (low) and 200 (high) °/s. The range of hip joint movements was from 30 (in flexion) to 130° (in extension). Torque values and their ratios for hip flexors and extensors at different angular positions were obtained and compared. It is shown that, at high speeds, the flexion movement significantly raises ( p < 0.001) the torque ratios of flexors and extensors in flexion positions of the hip (50 and 60°). These ratios approximately twofold exceed their values at moderate velocities. The weakness of hip joint extensors in extreme flexion positions of the hip may cause injury of this group of muscles at fast movements.

A fast low-power optical memory based on coupled micro-ring lasers

NASA Astrophysics Data System (ADS)

Hill, Martin T.; Dorren, Harmen J. S.; de Vries, Tjibbe; Leijtens, Xaveer J. M.; den Besten, Jan Hendrik; Smalbrugge, Barry; Oei, Yok-Siang; Binsma, Hans; Khoe, Giok-Djan; Smit, Meint K.

2004-11-01

The increasing speed of fibre-optic-based telecommunications has focused attention on high-speed optical processing of digital information. Complex optical processing requires a high-density, high-speed, low-power optical memory that can be integrated with planar semiconductor technology for buffering of decisions and telecommunication data. Recently, ring lasers with extremely small size and low operating power have been made, and we demonstrate here a memory element constructed by interconnecting these microscopic lasers. Our device occupies an area of 18 × 40µm2 on an InP/InGaAsP photonic integrated circuit, and switches within 20ps with 5.5fJ optical switching energy. Simulations show that the element has the potential for much smaller dimensions and switching times. Large numbers of such memory elements can be densely integrated and interconnected on a photonic integrated circuit: fast digital optical information processing systems employing large-scale integration should now be viable.

Structural basis for the fast maturation of Arthropoda green fluorescent protein

PubMed Central

Evdokimov, Artem G; Pokross, Matthew E; Egorov, Nikolay S; Zaraisky, Andrey G; Yampolsky, Ilya V; Merzlyak, Ekaterina M; Shkoporov, Andrey N; Sander, Ian; Lukyanov, Konstantin A; Chudakov, Dmitriy M

2006-01-01

Since the cloning of Aequorea victoria green fluorescent protein (GFP) in 1992, a family of known GFP-like proteins has been growing rapidly. Today, it includes more than a hundred proteins with different spectral characteristics cloned from Cnidaria species. For some of these proteins, crystal structures have been solved, showing diversity in chromophore modifications and conformational states. However, we are still far from a complete understanding of the origin, functions and evolution of the GFP family. Novel proteins of the family were recently cloned from evolutionarily distant marine Copepoda species, phylum Arthropoda, demonstrating an extremely rapid generation of fluorescent signal. Here, we have generated a non-aggregating mutant of Copepoda fluorescent protein and solved its high-resolution crystal structure. It was found that the protein β-barrel contains a pore, leading to the chromophore. Using site-directed mutagenesis, we showed that this feature is critical for the fast maturation of the chromophore. PMID:16936637

Vibrational dynamics of aniline (N2)1 clusters in their first excited singlet state

NASA Astrophysics Data System (ADS)

Hineman, M. F.; Kim, S. K.; Bernstein, E. R.; Kelley, D. F.

1992-04-01

The first excited singlet state S1 vibrational dynamics of aniline(N2)1 clusters are studied and compared to previous results on aniline(CH4)1 and aniline(Ar)1. Intramolecular vibrational energy redistribution (IVR) and vibrational predissociation (VP) rates fall between the two extremes of the CH4 (fast IVR, slow VP) and Ar (slow IVR, fast VP) cluster results as is predicted by a serial IVR/VP model using Fermi's golden rule to describe IVR processes and a restricted Rice-Ramsperger-Kassel-Marcus (RRKM) theory to describe unimolecular VP rates. The density of states is the most important factor determining the rates. Two product states, 00 and 10b1, of bare aniline and one intermediate state ˜(00) in the overall IVR/VP process are observed and time resolved measurements are obtained for the 000 and ˜(000) transitions. The results are modeled with the serial mechanism described above.

A 10MHz Fiber-Coupled Photodiode Imaging Array for Plasma Diagnostics

NASA Astrophysics Data System (ADS)

Brockington, Samuel; Case, Andrew; Witherspoon, F. Douglas

2013-10-01

HyperV Technologies has been developing an imaging diagnostic comprised of arrays of fast, low-cost, long-record-length, fiber-optically-coupled photodiode channels to investigate plasma dynamics and other fast, bright events. By coupling an imaging fiber bundle to a bank of amplified photodiode channels, imagers and streak imagers of 100 to 10,000 pixels can be constructed. By interfacing analog photodiode systems directly to commercial analog to digital convertors and modern memory chips, a prototype pixel with an extremely deep record length (128 k points at 40 Msamples/s) has been achieved for a 10 bit resolution system with signal bandwidths of at least 10 MHz. Progress on a prototype 100 Pixel streak camera employing this technique is discussed along with preliminary experimental results and plans for a 10,000 pixel imager. Work supported by USDOE Phase 1 SBIR Grant DE-SC0009492.

Is fast food addictive?

PubMed

Garber, Andrea K; Lustig, Robert H

2011-09-01

Studies of food addiction have focused on highly palatable foods. While fast food falls squarely into that category, it has several other attributes that may increase its salience. This review examines whether the nutrients present in fast food, the characteristics of fast food consumers or the presentation and packaging of fast food may encourage substance dependence, as defined by the American Psychiatric Association. The majority of fast food meals are accompanied by a soda, which increases the sugar content 10-fold. Sugar addiction, including tolerance and withdrawal, has been demonstrated in rodents but not humans. Caffeine is a "model" substance of dependence; coffee drinks are driving the recent increase in fast food sales. Limited evidence suggests that the high fat and salt content of fast food may increase addictive potential. Fast food restaurants cluster in poorer neighborhoods and obese adults eat more fast food than those who are normal weight. Obesity is characterized by resistance to insulin, leptin and other hormonal signals that would normally control appetite and limit reward. Neuroimaging studies in obese subjects provide evidence of altered reward and tolerance. Once obese, many individuals meet criteria for psychological dependence. Stress and dieting may sensitize an individual to reward. Finally, fast food advertisements, restaurants and menus all provide environmental cues that may trigger addictive overeating. While the concept of fast food addiction remains to be proven, these findings support the role of fast food as a potentially addictive substance that is most likely to create dependence in vulnerable populations.

Case report : tuberculosis liver abscess in male alcoholism patient

NASA Astrophysics Data System (ADS)

Siahaan, W. P.; Ginting, F.

2018-03-01

A liver abscess often occurs in low-middle income countries such as Indonesia. Two most common liver abscesses are amoebic and pyogenic liver abscess. Data that reported tuberculosis liver abscess (TLA) is extremely rare. A diagnostic criterion for tuberculosis liver abscess is rare and remains unclear. A 52-year-old man developed a TLA which was not associated with any pulmonary or gastrointestinal tract foci of tuberculosis. An ultrasonogram and abdominal scan showed an abscess in the right lobe. We performed paracentesis, and the pus from the lesion was positive tubercular bacilli on acid-fast bacilli staining. The patient was started on systemic antitubercular therapy to which he responded favorably. This report emphasizes the fact that, although a TLA is a very rare entity, it should be included in the differential diagnosis of liver abscess especially in Indonesia where the prevalence of tuberculosis is extremely high.

Extreme ecosystem instability suppressed tropical dinosaur dominance for 30 million years.

PubMed

Whiteside, Jessica H; Lindström, Sofie; Irmis, Randall B; Glasspool, Ian J; Schaller, Morgan F; Dunlavey, Maria; Nesbitt, Sterling J; Smith, Nathan D; Turner, Alan H

2015-06-30

A major unresolved aspect of the rise of dinosaurs is why early dinosaurs and their relatives were rare and species-poor at low paleolatitudes throughout the Late Triassic Period, a pattern persisting 30 million years after their origin and 10-15 million years after they became abundant and speciose at higher latitudes. New palynological, wildfire, organic carbon isotope, and atmospheric pCO2 data from early dinosaur-bearing strata of low paleolatitudes in western North America show that large, high-frequency, tightly correlated variations in δ(13)Corg and palynomorph ecotypes occurred within a context of elevated and increasing pCO2 and pervasive wildfires. Whereas pseudosuchian archosaur-dominated communities were able to persist in these same regions under rapidly fluctuating extreme climatic conditions until the end-Triassic, large-bodied, fast-growing tachymetabolic dinosaurian herbivores requiring greater resources were unable to adapt to unstable high CO2 environmental conditions of the Late Triassic.

Earth's magnetosphere and outer radiation belt under sub-Alfvénic solar wind

PubMed Central

Lugaz, Noé; Farrugia, Charles J.; Huang, Chia-Lin; Winslow, Reka M.; Spence, Harlan E.; Schwadron, Nathan A.

2016-01-01

The interaction between Earth's magnetic field and the solar wind results in the formation of a collisionless bow shock 60,000–100,000 km upstream of our planet, as long as the solar wind fast magnetosonic Mach (hereafter Mach) number exceeds unity. Here, we present one of those extremely rare instances, when the solar wind Mach number reached steady values <1 for several hours on 17 January 2013. Simultaneous measurements by more than ten spacecraft in the near-Earth environment reveal the evanescence of the bow shock, the sunward motion of the magnetopause and the extremely rapid and intense loss of electrons in the outer radiation belt. This study allows us to directly observe the state of the inner magnetosphere, including the radiation belts during a type of solar wind-magnetosphere coupling which is unusual for planets in our solar system but may be common for close-in extrasolar planets. PMID:27694887

Extreme ecosystem instability suppressed tropical dinosaur dominance for 30 million years

NASA Astrophysics Data System (ADS)

Whiteside, Jessica H.; Lindström, Sofie; Irmis, Randall B.; Glasspool, Ian J.; Schaller, Morgan F.; Dunlavey, Maria; Nesbitt, Sterling J.; Smith, Nathan D.; Turner, Alan H.

2015-06-01

A major unresolved aspect of the rise of dinosaurs is why early dinosaurs and their relatives were rare and species-poor at low paleolatitudes throughout the Late Triassic Period, a pattern persisting 30 million years after their origin and 10-15 million years after they became abundant and speciose at higher latitudes. New palynological, wildfire, organic carbon isotope, and atmospheric pCO2 data from early dinosaur-bearing strata of low paleolatitudes in western North America show that large, high-frequency, tightly correlated variations in δ13Corg and palynomorph ecotypes occurred within a context of elevated and increasing pCO2 and pervasive wildfires. Whereas pseudosuchian archosaur-dominated communities were able to persist in these same regions under rapidly fluctuating extreme climatic conditions until the end-Triassic, large-bodied, fast-growing tachymetabolic dinosaurian herbivores requiring greater resources were unable to adapt to unstable high CO2 environmental conditions of the Late Triassic.

Earth's magnetosphere and outer radiation belt under sub-Alfvénic solar wind.

PubMed

Lugaz, Noé; Farrugia, Charles J; Huang, Chia-Lin; Winslow, Reka M; Spence, Harlan E; Schwadron, Nathan A

2016-10-03

The interaction between Earth's magnetic field and the solar wind results in the formation of a collisionless bow shock 60,000-100,000 km upstream of our planet, as long as the solar wind fast magnetosonic Mach (hereafter Mach) number exceeds unity. Here, we present one of those extremely rare instances, when the solar wind Mach number reached steady values <1 for several hours on 17 January 2013. Simultaneous measurements by more than ten spacecraft in the near-Earth environment reveal the evanescence of the bow shock, the sunward motion of the magnetopause and the extremely rapid and intense loss of electrons in the outer radiation belt. This study allows us to directly observe the state of the inner magnetosphere, including the radiation belts during a type of solar wind-magnetosphere coupling which is unusual for planets in our solar system but may be common for close-in extrasolar planets.

Percolation technique for galaxy clustering

NASA Technical Reports Server (NTRS)

Klypin, Anatoly; Shandarin, Sergei F.

1993-01-01

We study percolation in mass and galaxy distributions obtained in 3D simulations of the CDM, C + HDM, and the power law (n = -1) models in the Omega = 1 universe. Percolation statistics is used here as a quantitative measure of the degree to which a mass or galaxy distribution is of a filamentary or cellular type. The very fast code used calculates the statistics of clusters along with the direct detection of percolation. We found that the two parameters mu(infinity), characterizing the size of the largest cluster, and mu-squared, characterizing the weighted mean size of all clusters excluding the largest one, are extremely useful for evaluating the percolation threshold. An advantage of using these parameters is their low sensitivity to boundary effects. We show that both the CDM and the C + HDM models are extremely filamentary both in mass and galaxy distribution. The percolation thresholds for the mass distributions are determined.

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

PubMed

Schneider, Elena K; Reyes-Ortega, Felisa; Velkov, Tony; Li, Jian

2017-02-28

The emergence of antimicrobial resistance of Gram-negative pathogens has become a worldwide crisis. The status quo for combating resistance is to employ synergistic combinations of antibiotics. Faced with this fast-approaching post-antibiotic era, it is critical that we devise strategies to prolong and maximize the clinical efficacy of existing antibiotics. Unfortunately, reports of extremely drug-resistant (XDR) Gram-negative pathogens have become more common. Combining antibiotics such as polymyxin B or the broad-spectrum tetracycline and minocycline with various FDA-approved non-antibiotic drugs have emerged as a novel combination strategy against otherwise untreatable XDR pathogens. This review surveys the available literature on the potential benefits of employing antibiotic-non-antibiotic drug combination therapy. The apex of this review highlights the clinical utility of this novel therapeutic strategy for combating infections caused by 'superbugs'. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Motor Unit Changes Seen With Skeletal Muscle Sarcopenia in Oldest Old Rats

PubMed Central

Kung, Theodore A.; van der Meulen, Jack H.; Urbanchek, Melanie G.; Kuzon, William M.; Faulkner, John A.

2014-01-01

Sarcopenia leads to many changes in skeletal muscle that contribute to atrophy, force deficits, and subsequent frailty. The purpose of this study was to characterize motor unit remodeling related to sarcopenia seen in extreme old age. Whole extensor digitorum longus muscle and motor unit contractile properties were measured in 19 adult (11–13 months) and 12 oldest old (36–37 months) Brown-Norway rats. Compared with adults, oldest old rats had significantly fewer motor units per muscle, smaller muscle cross-sectional area, and lower muscle specific force. However, mean motor unit force generation was similar between the two groups due to an increase in innervation ratio by the oldest old rats. These findings suggest that even in extreme old age both fast- and slow-twitch motor units maintain the ability to undergo motor unit remodeling that offsets some effects of sarcopenia. PMID:24077596

Extreme ecosystem instability suppressed tropical dinosaur dominance for 30 million years

PubMed Central

Whiteside, Jessica H.; Lindström, Sofie; Irmis, Randall B.; Glasspool, Ian J.; Schaller, Morgan F.; Dunlavey, Maria; Nesbitt, Sterling J.; Smith, Nathan D.; Turner, Alan H.

2015-01-01

A major unresolved aspect of the rise of dinosaurs is why early dinosaurs and their relatives were rare and species-poor at low paleolatitudes throughout the Late Triassic Period, a pattern persisting 30 million years after their origin and 10–15 million years after they became abundant and speciose at higher latitudes. New palynological, wildfire, organic carbon isotope, and atmospheric pCO2 data from early dinosaur-bearing strata of low paleolatitudes in western North America show that large, high-frequency, tightly correlated variations in δ13Corg and palynomorph ecotypes occurred within a context of elevated and increasing pCO2 and pervasive wildfires. Whereas pseudosuchian archosaur-dominated communities were able to persist in these same regions under rapidly fluctuating extreme climatic conditions until the end-Triassic, large-bodied, fast-growing tachymetabolic dinosaurian herbivores requiring greater resources were unable to adapt to unstable high CO2 environmental conditions of the Late Triassic. PMID:26080428

Plans for the extreme ultraviolet explorer data base

NASA Technical Reports Server (NTRS)

Marshall, Herman L.; Dobson, Carl A.; Malina, Roger F.; Bowyer, Stuart

1988-01-01

The paper presents an approach for storage and fast access to data that will be obtained by the Extreme Ultraviolet Explorer (EUVE), a satellite payload scheduled for launch in 1991. The EUVE telescopes will be operated remotely from the EUVE Science Operation Center (SOC) located at the University of California, Berkeley. The EUVE science payload consists of three scanning telescope carrying out an all-sky survey in the 80-800 A spectral region and a Deep Survey/Spectrometer telescope performing a deep survey in the 80-250 A spectral region. Guest Observers will remotely access the EUVE spectrometer database at the SOC. The EUVE database will consist of about 2 X 10 to the 10th bytes of information in a very compact form, very similar to the raw telemetry data. A history file will be built concurrently giving telescope parameters, command history, attitude summaries, engineering summaries, anomalous events, and ephemeris summaries.

Forecasting Financial Extremes: A Network Degree Measure of Super-Exponential Growth.

PubMed

Yan, Wanfeng; van Tuyll van Serooskerken, Edgar

2015-01-01

Investors in stock market are usually greedy during bull markets and scared during bear markets. The greed or fear spreads across investors quickly. This is known as the herding effect, and often leads to a fast movement of stock prices. During such market regimes, stock prices change at a super-exponential rate and are normally followed by a trend reversal that corrects the previous overreaction. In this paper, we construct an indicator to measure the magnitude of the super-exponential growth of stock prices, by measuring the degree of the price network, generated from the price time series. Twelve major international stock indices have been investigated. Error diagram tests show that this new indicator has strong predictive power for financial extremes, both peaks and troughs. By varying the parameters used to construct the error diagram, we show the predictive power is very robust. The new indicator has a better performance than the LPPL pattern recognition indicator.

Health beliefs and practices of Muslim women during Ramadan.

PubMed

Kridli, Suha Al-Oballi

2011-01-01

There are clear exemptions in Islam from fasting in Ramadan during sickness, pregnancy, and breastfeeding. Yet, some Muslim women still elect to fast while sick, pregnant, or breastfeeding because of a confluence of social, religious, and cultural factors. Little is known about the physiological effects of fasting during Ramadan on the mother or her unborn baby, and thus nurses and other healthcare providers are faced with the difficult task of providing appropriate medical advice to Muslim women regarding the safety and impact of their fasting. This article describes what is known about this topic and suggests that healthcare professionals learn as much as possible about the multicultural best practices and research-driven information about fasting in order to help Muslim women make informed decisions.

Improved methods for simulating nearly extremal binary black holes

NASA Astrophysics Data System (ADS)

Scheel, Mark A.; Giesler, Matthew; Hemberger, Daniel A.; Lovelace, Geoffrey; Kuper, Kevin; Boyle, Michael; Szilágyi, Béla; Kidder, Lawrence E.

2015-05-01

Astrophysical black holes could be nearly extremal (that is, rotating nearly as fast as possible); therefore, nearly extremal black holes could be among the binaries that current and future gravitational-wave observatories will detect. Predicting the gravitational waves emitted by merging black holes requires numerical-relativity simulations, but these simulations are especially challenging when one or both holes have mass m and spin S exceeding the Bowen-York limit of S/{{m}2}=0.93. We present improved methods that enable us to simulate merging, nearly extremal black holes (i.e., black holes with S/{{m}2}\\gt 0.93) more robustly and more efficiently. We use these methods to simulate an unequal-mass, precessing binary black hole (BBH) coalescence, where the larger black hole has S/{{m}2}=0.99. We also use these methods to simulate a non-precessing BBH coalescence, where both black holes have S/{{m}2}=0.994, nearly reaching the Novikov-Thorne upper bound for holes spun up by thin accretion disks. We demonstrate numerical convergence and estimate the numerical errors of the waveforms; we compare numerical waveforms from our simulations with post-Newtonian and effective-one-body waveforms; we compare the evolution of the black hole masses and spins with analytic predictions; and we explore the effect of increasing spin magnitude on the orbital dynamics (the so-called ‘orbital hangup’ effect).

Rapid decadal convective precipitation increase over Eurasia during the last three decades of the 20th century.

PubMed

Ye, Hengchun; Fetzer, Eric J; Wong, Sun; Lambrigtsen, Bjorn H

2017-01-01

Convective precipitation-localized, short-lived, intense, and sometimes violent-is at the root of challenges associated with observation, simulation, and prediction of precipitation. The understanding of long-term changes in convective precipitation characteristics and their role in precipitation extremes and intensity over extratropical regions are imperative to future water resource management; however, they have been studied very little. We show that annual convective precipitation total has been increasing astonishingly fast, at a rate of 18.4%/°C, of which 16% is attributable to an increase in convective precipitation occurrence, and 2.4% is attributable to increased daily intensity based on the 35 years of two (combined) historical data sets of 3-hourly synoptic observations and daily precipitation. We also reveal that annual daily precipitation extreme has been increasing at a rate of about 7.4%/°C in convective events only. Concurrently, the overall increase in mean daily precipitation intensity is mostly due to increased convective precipitation, possibly at the expanse of nonconvective precipitation. As a result, transitional seasons are becoming more summer-like as convective becomes the dominant precipitation type that has accompanied higher daily extremes and intensity since the late 1980s. The data also demonstrate that increasing convective precipitation and daily extremes appear to be directly linearly associated with higher atmospheric water vapor accompanying a warming climate over northern Eurasia.

Rapid decadal convective precipitation increase over Eurasia during the last three decades of the 20th century

PubMed Central

Ye, Hengchun; Fetzer, Eric J.; Wong, Sun; Lambrigtsen, Bjorn H.

2017-01-01

Convective precipitation—localized, short-lived, intense, and sometimes violent—is at the root of challenges associated with observation, simulation, and prediction of precipitation. The understanding of long-term changes in convective precipitation characteristics and their role in precipitation extremes and intensity over extratropical regions are imperative to future water resource management; however, they have been studied very little. We show that annual convective precipitation total has been increasing astonishingly fast, at a rate of 18.4%/°C, of which 16% is attributable to an increase in convective precipitation occurrence, and 2.4% is attributable to increased daily intensity based on the 35 years of two (combined) historical data sets of 3-hourly synoptic observations and daily precipitation. We also reveal that annual daily precipitation extreme has been increasing at a rate of about 7.4%/°C in convective events only. Concurrently, the overall increase in mean daily precipitation intensity is mostly due to increased convective precipitation, possibly at the expanse of nonconvective precipitation. As a result, transitional seasons are becoming more summer-like as convective becomes the dominant precipitation type that has accompanied higher daily extremes and intensity since the late 1980s. The data also demonstrate that increasing convective precipitation and daily extremes appear to be directly linearly associated with higher atmospheric water vapor accompanying a warming climate over northern Eurasia. PMID:28138545

Muslim patients in Ramadan: A review for primary care physicians

PubMed Central

Abolaban, Heba; Al-Moujahed, Ahmad

2017-01-01

Fasting Ramadan, in which Muslims abstain from specific habits and behaviors from dawn to sunset, is one of the five Pillars of Islam. While there are several exemptions from fasting, many Muslim patients with acute or chronic medical conditions still choose to fast, which may adversely affect their health if not addressed properly. Some patients may not be well educated about the effects of some medical treatments and procedures on the validity of their fast, which can unnecessarily lead to suboptimal management of their conditions or treatment nonadherence. Since spirituality, religiosity, and personal beliefs affect patients' health behaviors and adherence to treatments, health-care providers need to learn how fasting Ramadan can affect the health of their Muslim patients, especially those with chronic medical conditions, and how to help them achieve safe fasting. This article aims to provide an overview of the main topics that primary care physicians may need to know in order to improve their cultural competence when caring for their fasting Muslim patients. PMID:28791239

Diabetes Canada Position Statement for People with Types 1 and 2 Diabetes Who Fast During Ramadan.

PubMed

Bajaj, Harpreet Singh; Abouhassan, Tyceer; Ahsan, Muhammad Rauf; Arnaout, Amel; Hassanein, Mohamed; Houlden, Robyn L; Khan, Tayyab; Khandwala, Hasnain; Verma, Subodh

2018-04-27

Fasting from dawn to dusk during Ramadan, including abstaining from water and food, is 1 of the pillars of Islam and is observed by the majority of Muslims. Most research concerning diabetes and fasting during Ramadan originates from Middle Eastern or South Asian countries; however, differences exist in hours of work and fasting, pharmacotherapy and blood glucose monitoring between these countries and Canada. An expert forum of 7 Canadian experts and 1 international expert collaborated to develop Canadian guidelines using the same evidence-based principles, with the exception of an independent methods review used for the Diabetes Canada clinical practice guidelines. Diabetes Canada scientific leadership and Canadian health-care providers performed independent external reviews. Religious leaders endorsed the position statement and provided letters of support. An informed patient participated in the position-statement development. Each recommendation was approved with 100% consensus of the expert forum. Recommendations for risk stratification, education, pharmacotherapy and blood glucose monitoring for adults with type 1 and type 2 diabetes who intend to fast during Ramadan have been developed. This is the first Canadian position statement on the topic of Ramadan fasting and diabetes. It was developed by an expert faculty and endorsed by Diabetes Canada, and provides guidance about pharmacotherapy and glucose monitoring for health-care providers so that they can assist Canadian Muslims living with diabetes to observe fasting during Ramadan safely. Copyright © 2018. Published by Elsevier Inc.

Availability of healthier options in traditional and nontraditional rural fast-food outlets

PubMed Central

Creel, Jennifer S; Sharkey, Joseph R; McIntosh, Alex; Anding, Jenna; Huber, J Charles

2008-01-01

Background Food prepared away from home has become increasingly popular to U.S. families, and may contribute to obesity. Sales have been dominated by fast food outlets, where meals are purchased for dining away from home or in the home. Although national chain affiliated fast-food outlets are considered the main source for fast food, fast foods are increasingly available in convenience stores and supermarkets/grocery stores. In rural areas, these nontraditional fast-food outlets may provide most of the opportunities for procurement of fast foods. Methods Using all traditional and nontraditio nal fast-food outlets identified in six counties in rural Texas, the type and number of regular and healthiermenu options were surveyed using on-site observation in all food venues that were primarily fast food, supermarket/grocery store, and convenience store and compared with 2005 Dietary Guidelines. Results Traditional fast-food outlets represented 84 (41%) of the 205 opportunities for procurement of fast food; 109 (53.2%) were convenience stores and 12 (5.8%) supermarkets/grocery stores. Although a s imilar variety of regular breakfast and lunch/dinner entrées were available in traditional fast-food outlets and convenience stores, the variety of healthier breakfast and lunch/dinner entrées was significantly greater in fast food outlets. Compared with convenience stores, supermarkets/grocery stores provided a greater variety of regular and healthier entrées and lunch/dinner side dishes. Conclusion Convenience stores and supermarkets/grocery stores more than double the potential access to fast foods in this rural area than traditional fast-food outlets alone; however, traditional fast food outlets offer greater opportunity for healthier fast food options than convenience stores. A complete picture of fast food environment and the availability of healthier fast food options are essential to understand environmental influences on diet and health outcomes, and identify potential targets for intervention. PMID:19040722

Assessing the features of extreme smog in China and the differentiated treatment strategy

NASA Astrophysics Data System (ADS)

Deng, Lu; Zhang, Zhengjun

2018-01-01

Extreme smog can have potentially harmful effects on human health, the economy and daily life. However, the average (mean) values do not provide strategically useful information on the hazard analysis and control of extreme smog. This article investigates China's smog extremes by applying extreme value analysis to hourly PM2.5 data from 2014 to 2016 obtained from monitoring stations across China. By fitting a generalized extreme value (GEV) distribution to exceedances over a station-specific extreme smog level at each monitoring location, all study stations are grouped into eight different categories based on the estimated mean and shape parameter values of fitted GEV distributions. The extreme features characterized by the mean of the fitted extreme value distribution, the maximum frequency and the tail index of extreme smog at each location are analysed. These features can provide useful information for central/local government to conduct differentiated treatments in cities within different categories and conduct similar prevention goals and control strategies among those cities belonging to the same category in a range of areas. Furthermore, hazardous hours, breaking probability and the 1-year return level of each station are demonstrated by category, based on which the future control and reduction targets of extreme smog are proposed for the cities of Beijing, Tianjin and Hebei as an example.

Readout concepts for the suppression of the slow component of BaF2 for the upgrade of the TAPS spectrometer at ELSA

NASA Astrophysics Data System (ADS)

Diehl, Stefan; Novotny, Rainer W.; Wohlfahrt, Benjamin; Beck, Reinhard

2015-02-01

For the measurement at extremely high interaction rates with fast scintillators, pile-up of consecutive events is a limiting factor. With a decay time of 600 ps of the fast crossluminescence component, Barium Fluoride (BaF2) is one of the fastest inorganic scintillators known today. However, the dominating slow component with a 3 orders of magnitude longer decay time of 630 ns limits the rate capability. To circumvent this limit, different approaches have been made in the past. The slow component can be suppressed for example by doping the crystals with rare earth ions like La3+. The paper will give an overview over the various concepts investigated in the past and present the suppression via optical band pass filters. This method has been chosen for the upgrade of the BaF2 crystals in the most forward region of the TAPS-spectrometer at ELSA in Bonn. It allows to reuse the existing crystals and to achieve a high degree of suppression of the slow component. The focus of the paper will be on the selection of the filters, the achievable rate capability and the energy resolution of the fast component.

Fast assessment of planar chromatographic layers quality using pulse thermovision method.

PubMed

Suszyński, Zbigniew; Świta, Robert; Loś, Joanna; Zarzycka, Magdalena B; Kaleniecka, Aleksandra; Zarzycki, Paweł K

2014-12-19

The main goal of this paper is to demonstrate capability of pulse thermovision (thermal-wave) methodology for sensitive detection of photothermal non-uniformities within light scattering and semi-transparent planar stationary phases. Successful visualization of stationary phases defects required signal processing protocols based on wavelet filtration, correlation analysis and k-means 3D segmentation. Such post-processing data handling approach allows extremely sensitive detection of thickness and structural changes within commercially available planar chromatographic layers. Particularly, a number of TLC and HPTLC stationary phases including silica, cellulose, aluminum oxide, polyamide and octadecylsilane coated with adsorbent layer ranging from 100 to 250μm were investigated. Presented detection protocol can be used as an efficient tool for fast screening the overall heterogeneity of any layered materials. Moreover, described procedure is very fast (few seconds including acquisition and data processing) and may be applied for fabrication processes online controlling. In spite of planar chromatographic plates this protocol can be used for assessment of different planar separation tools like paper based analytical devices or micro total analysis systems, consisted of organic and non-organic layers. Copyright © 2014 Elsevier B.V. All rights reserved.

Fast detection of peroxidase (POD) activity in tomato leaves which infected with Botrytis cinerea using hyperspectral imaging

NASA Astrophysics Data System (ADS)

Kong, Wenwen; Liu, Fei; Zhang, Chu; Bao, Yidan; Yu, Jiajia; He, Yong

2014-01-01

Tomatoes are cultivated around the world and gray mold is one of its most prominent and destructive diseases. An early disease detection method can decrease losses caused by plant diseases and prevent the spread of diseases. The activity of peroxidase (POD) is very important indicator of disease stress for plants. The objective of this study is to examine the possibility of fast detection of POD activity in tomato leaves which infected with Botrytis cinerea using hyperspectral imaging data. Five pre-treatment methods were investigated. Genetic algorithm-partial least squares (GA-PLS) was applied to select optimal wavelengths. A new fast learning neural algorithm named extreme learning machine (ELM) was employed as multivariate analytical tool in this study. 21 optimal wavelengths were selected by GA-PLS and used as inputs of three calibration models. The optimal prediction result was achieved by ELM model with selected wavelengths, and the r and RMSEP in validation were 0.8647 and 465.9880 respectively. The results indicated that hyperspectral imaging could be considered as a valuable tool for POD activity prediction. The selected wavelengths could be potential resources for instrument development.

Personality matters: individual variation in reactions of naive bird predators to aposematic prey.

PubMed

Exnerová, Alice; Svádová, Katerina Hotová; Fucíková, Eva; Drent, Pieter; Stys, Pavel

2010-03-07

Variation in reactions to aposematic prey is common among conspecific individuals of bird predators. It may result from different individual experience but it also exists among naive birds. This variation may possibly be explained by the effect of personality--a complex of correlated, heritable behavioural traits consistent across contexts. In the great tit (Parus major), two extreme personality types have been defined. 'Fast' explorers are bold, aggressive and routine-forming; 'slow' explorers are shy, non-aggressive and innovative. Influence of personality type on unlearned reaction to aposematic prey, rate of avoidance learning and memory were tested in naive, hand-reared great tits from two opposite lines selected for exploration (slow against fast). The birds were subjected to a sequence of trials in which they were offered aposematic adult firebugs (Pyrrhocoris apterus). Slow birds showed a greater degree of unlearned wariness and learned to avoid the firebugs faster than fast birds. Although birds of both personality types remembered their experience, slow birds were more cautious in the memory test. We conclude that not only different species but also populations of predators that differ in proportions of personality types may have different impacts on survival of aposematic insects under natural conditions.

76 FR 38360 - Workshop-Monitoring Changes in Extreme Storm Statistics: State of Knowledge; Notice of Open...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... Changes in Extreme Storm Statistics: State of Knowledge; Notice of Open Public Workshop AGENCY: National... .) SUPPLEMENTARY INFORMATION: This workshop will provide an update to the climate science surrounding extreme... storms. Specific topics include: Severe Thunderstorms (and associated hail and winds), tornadoes, extreme...

Complete genome sequence, metabolic model construction and phenotypic characterization of Geobacillus LC300, an extremely thermophilic, fast growing, xylose-utilizing bacterium.

PubMed

Cordova, Lauren T; Long, Christopher P; Venkataramanan, Keerthi P; Antoniewicz, Maciek R

2015-11-01

We have isolated a new extremely thermophilic fast-growing Geobacillus strain that can efficiently utilize xylose, glucose, mannose and galactose for cell growth. When grown aerobically at 72 °C, Geobacillus LC300 has a growth rate of 2.15 h(-1) on glucose and 1.52 h(-1) on xylose (doubling time less than 30 min). The corresponding specific glucose and xylose utilization rates are 5.55 g/g/h and 5.24 g/g/h, respectively. As such, Geobacillus LC300 grows 3-times faster than E. coli on glucose and xylose, and has a specific xylose utilization rate that is 3-times higher than the best metabolically engineered organism to date. To gain more insight into the metabolism of Geobacillus LC300 its genome was sequenced using PacBio's RS II single-molecule real-time (SMRT) sequencing platform and annotated using the RAST server. Based on the genome annotation and the measured biomass composition a core metabolic network model was constructed. To further demonstrate the biotechnological potential of this organism, Geobacillus LC300 was grown to high cell-densities in a fed-batch culture, where cells maintained a high xylose utilization rate under low dissolved oxygen concentrations. All of these characteristics make Geobacillus LC300 an attractive host for future metabolic engineering and biotechnology applications. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.