Micropaleontology of selected wells and seismic shot holes, northern Alaska

USGS Publications Warehouse

Mickey, Michael B.; Haga, Hideyo; Bird, Kenneth J.

2006-01-01

This report provides micropaleontologic data (foraminifera, pollen, spores, and microplankton) and interpretations of the rocks penetrated by 49 wells and 3,134 seismic shot holes distributed among 73 seismic lines (figs. 1, 2; table 1). All shot holes and 30 wells are located within the National Petroleum Reserve in Alaska (NPRA); the remaining 19 wells are located adjacent to the NPRA. The biostratigraphic zonation scheme, stratigraphy, and geologic ages followed in this study are summarized in figure 3. This update brings paleontologic analyses performed at various times over several decades to a current, unified set of interpretations that benefit from the evolution of northern Alaska biostratigraphic understanding developed during the past 33-years by Mickey and Haga. For each well, paleontologic information includes microfossil distribution charts, data spreadsheets, diversity graphs, and interpretive reports describing age and environments of deposition. Three biostratigraphic well-correlation sections that relate Chukchi Sea wells to onshore northwestern NPRA wells are also included. For all analyzed seismic shot hole samples, foraminiferal age and environmental interpretations are provided; palynological interpretations are provided only for those shot hole samples collected and analyzed after 1976, a little less than half of the total number of samples.

Time to Go Beyond Triple-Gauge-Boson-Coupling Interpretation of W Pair Production.

PubMed

Zhang, Zhengkang

2017-01-06

W boson pair production processes at e^{+}e^{-} and pp colliders have been conventionally interpreted as measurements of WWZ and WWγ triple gauge couplings (TGCs). Such an interpretation is based on the assumption that new physics effects other than anomalous TGCs are negligible. While this "TGC dominance assumption" was well motivated and useful at LEP2 thanks to precision electroweak constraints, it is already challenged by recent LHC data. In fact, contributions from anomalous Z boson couplings that are allowed by electroweak precision data but neglected in LHC analyses, which are enhanced at high energy, can even dominate over those from the anomalous TGCs considered. This limits the generality of the anomalous TGC constraints derived in current analyses and necessitates extension of the analysis framework and a change of physics interpretation. The issue will persist as we continue to explore the high-energy frontier. We clarify and analyze the situation in the effective field theory framework, which provides a useful organizing principle for understanding standard model deviations in the high-energy regime.

Microbiome Networks: A Systems Framework for Identifying Candidate Microbial Assemblages for Disease Management.

PubMed

Poudel, R; Jumpponen, A; Schlatter, D C; Paulitz, T C; Gardener, B B McSpadden; Kinkel, L L; Garrett, K A

2016-10-01

Network models of soil and plant microbiomes provide new opportunities for enhancing disease management, but also challenges for interpretation. We present a framework for interpreting microbiome networks, illustrating how observed network structures can be used to generate testable hypotheses about candidate microbes affecting plant health. The framework includes four types of network analyses. "General network analysis" identifies candidate taxa for maintaining an existing microbial community. "Host-focused analysis" includes a node representing a plant response such as yield, identifying taxa with direct or indirect associations with that node. "Pathogen-focused analysis" identifies taxa with direct or indirect associations with taxa known a priori as pathogens. "Disease-focused analysis" identifies taxa associated with disease. Positive direct or indirect associations with desirable outcomes, or negative associations with undesirable outcomes, indicate candidate taxa. Network analysis provides characterization not only of taxa with direct associations with important outcomes such as disease suppression, biofertilization, or expression of plant host resistance, but also taxa with indirect associations via their association with other key taxa. We illustrate the interpretation of network structure with analyses of microbiomes in the oak phyllosphere, and in wheat rhizosphere and bulk soil associated with the presence or absence of infection by Rhizoctonia solani.

Geologic and mineral and water resources investigations in western Colorado using ERTS-1 data

NASA Technical Reports Server (NTRS)

Knepper, D. H., Jr. (Compiler)

1973-01-01

The author has identified the following significant results. Geologic interpretation of ERTS-1 imagery is dependent on recognition of the distribution, continuity, trend, and geometry of key surface features. In the examination of ERTS-1 imagery, lithology must be interpreted largely from the geomorphic expression of the terrain. ERTS-1 imagery is extremely useful in detecting local structures. Most mapped structures are topographically-expressed. Consequently, ERTS-1 imagery acquired during mid-winter, when the solar illumination angle is low, provides the largest amount of structural information. Stereoscopic analyses of ERTS-1 images significantly aid geologic interpretation. Positive transparencies of ERTS-1 images (1:1,000,000) commonly contain more geologic information than can be adequately annotated during geologic interpretation.

Data and graph interpretation practices among preservice science teachers

NASA Astrophysics Data System (ADS)

Bowen, G. Michael; Roth, Wolff-Michael

2005-12-01

The interpretation of data and construction and interpretation of graphs are central practices in science, which, according to recent reform documents, science and mathematics teachers are expected to foster in their classrooms. However, are (preservice) science teachers prepared to teach inquiry with the purpose of transforming and analyzing data, and interpreting graphical representations? That is, are preservice science teachers prepared to teach data analysis and graph interpretation practices that scientists use by default in their everyday work? The present study was designed to answer these and related questions. We investigated the responses of preservice elementary and secondary science teachers to data and graph interpretation tasks. Our investigation shows that, despite considerable preparation, and for many, despite bachelor of science degrees, preservice teachers do not enact the (authentic) practices that scientists routinely do when asked to interpret data or graphs. Detailed analyses are provided of what data and graph interpretation practices actually were enacted. We conclude that traditional schooling emphasizes particular beliefs in the mathematical nature of the universe that make it difficult for many individuals to deal with data possessing the random variation found in measurements of natural phenomena. The results suggest that preservice teachers need more experience in engaging in data and graph interpretation practices originating in activities that provide the degree of variation in and complexity of data present in realistic investigations.

Electrical-power-system data base for consumables analysis. Volume 1: Electrical equipment list, activity blocks, and time lines

NASA Technical Reports Server (NTRS)

Pipher, M. D.; Green, P. A.; Wolfgram, D. F.

1975-01-01

A standardized data base is described which consists of a space shuttle electrical equipment list, activity blocks defining electrical equipment utilization, and activity-block time lines for specific mission analyses. Information is presented to facilitate utilization of the data base, to provide the basis for the electrical equipment utilization to enable interpretation of analyses based on the data contained herein.

Quantitative interpretation of the magnetic susceptibility frequency dependence

NASA Astrophysics Data System (ADS)

Ustra, Andrea; Mendonça, Carlos A.; Leite, Aruã; Jovane, Luigi; Trindade, Ricardo I. F.

2018-05-01

Low-field mass-specific magnetic susceptibility (MS) measurements using multifrequency alternating fields are commonly used to evaluate concentration of ferrimagnetic particles in the transition of superparamagnetic (SP) to stable single domain (SSD). In classical palaeomagnetic analyses, this measurement serves as a preliminary assessment of rock samples providing rapid, non-destructive, economical and easy information of magnetic properties. The SP-SSD transition is relevant in environmental studies because it has been associated with several geological and biogeochemical processes affecting magnetic mineralogy. MS is a complex function of mineral-type and grain-size distribution, as well as measuring parameters such as external field magnitude and frequency. In this work, we propose a new technique to obtain quantitative information on grain-size variations of magnetic particles in the SP-SSD transition by inverting frequency-dependent susceptibility. We introduce a descriptive parameter named as `limiting frequency effect' that provides an accurate estimation of MS loss with frequency. Numerical simulations show the methodology capability in providing data fitting and model parameters in many practical situations. Real-data applications with magnetite nanoparticles and core samples from sediments of Poggio le Guaine section of Umbria-Marche Basin (Italy) provide additional information not clearly recognized when interpreting cruder MS data. Caution is needed when interpreting frequency dependence in terms of single relaxation processes, which are not universally applicable and depend upon the nature of magnetic mineral in the material. Nevertheless, the proposed technique is a promising tool for SP-SSD content analyses.

Estimation and interpretation of genetic effects with epistasis using the NOIA model.

PubMed

Alvarez-Castro, José M; Carlborg, Orjan; Rönnegård, Lars

2012-01-01

We introduce this communication with a brief outline of the historical landmarks in genetic modeling, especially concerning epistasis. Then, we present methods for the use of genetic modeling in QTL analyses. In particular, we summarize the essential expressions of the natural and orthogonal interactions (NOIA) model of genetic effects. Our motivation for reviewing that theory here is twofold. First, this review presents a digest of the expressions for the application of the NOIA model, which are often mixed with intermediate and additional formulae in the original articles. Second, we make the required theory handy for the reader to relate the genetic concepts to the particular mathematical expressions underlying them. We illustrate those relations by providing graphical interpretations and a diagram summarizing the key features for applying genetic modeling with epistasis in comprehensive QTL analyses. Finally, we briefly review some examples of the application of NOIA to real data and the way it improves the interpretability of the results.

The Black Press and the Bakke Case.

ERIC Educational Resources Information Center

Poindexter, Paula M.; Stroman, Carolyn A.

1980-01-01

Content analyses of four Black newspapers during 1977 indicate that only one newspaper gave the Regents of the University of California v Bakke case substantial front-page coverage and suggest that most items provided only superficial facts about the case rather than interpretative information. (GT)

A perinatal signature of light on chronobiology? If so, numerous questions arise and experimental animal research must provide more information.

PubMed

Erren, Thomas C; Reiter, Russel J; Meyer-Rochow, V Benno

2012-01-01

That light and melatonin rhythms provide both clock and calendar information in humans and numerous other species is beyond dispute; this holds true for all stages of life, including the very early ones. Experimental evidence elucidates that exposure to light and melatonin titres are keys for the very development of circadian and seasonal rhythms. As evinced by a 2011 publication in Nature Neuroscience such awareness could impact considerably on the design and conduct of experimental studies as well as their subsequent analyses, interpretations and comparisons. Therefore "when and how experimental animals were bred, developed and raised" may be critical when experimenting with animals generally, and not just rodents. As long as the suggested imprinting of circadian system stability via light cues is not falsified, the perinatal season or perinatal experimental light:dark [L:D] conditions that an animal was kept under should be routinely recorded, published and considered in analysing and interpreting study data.

Testing Separability and Independence of Perceptual Dimensions with General Recognition Theory: A Tutorial and New R Package (grtools).

PubMed

Soto, Fabian A; Zheng, Emily; Fonseca, Johnny; Ashby, F Gregory

2017-01-01

Determining whether perceptual properties are processed independently is an important goal in perceptual science, and tools to test independence should be widely available to experimental researchers. The best analytical tools to test for perceptual independence are provided by General Recognition Theory (GRT), a multidimensional extension of signal detection theory. Unfortunately, there is currently a lack of software implementing GRT analyses that is ready-to-use by experimental psychologists and neuroscientists with little training in computational modeling. This paper presents grtools , an R package developed with the explicit aim of providing experimentalists with the ability to perform full GRT analyses using only a couple of command lines. We describe the software and provide a practical tutorial on how to perform each of the analyses available in grtools . We also provide advice to researchers on best practices for experimental design and interpretation of results when applying GRT and grtools .

Accelerometer Data Analysis and Presentation Techniques

NASA Technical Reports Server (NTRS)

Rogers, Melissa J. B.; Hrovat, Kenneth; McPherson, Kevin; Moskowitz, Milton E.; Reckart, Timothy

1997-01-01

The NASA Lewis Research Center's Principal Investigator Microgravity Services project analyzes Orbital Acceleration Research Experiment and Space Acceleration Measurement System data for principal investigators of microgravity experiments. Principal investigators need a thorough understanding of data analysis techniques so that they can request appropriate analyses to best interpret accelerometer data. Accelerometer data sampling and filtering is introduced along with the related topics of resolution and aliasing. Specific information about the Orbital Acceleration Research Experiment and Space Acceleration Measurement System data sampling and filtering is given. Time domain data analysis techniques are discussed and example environment interpretations are made using plots of acceleration versus time, interval average acceleration versus time, interval root-mean-square acceleration versus time, trimmean acceleration versus time, quasi-steady three dimensional histograms, and prediction of quasi-steady levels at different locations. An introduction to Fourier transform theory and windowing is provided along with specific analysis techniques and data interpretations. The frequency domain analyses discussed are power spectral density versus frequency, cumulative root-mean-square acceleration versus frequency, root-mean-square acceleration versus frequency, one-third octave band root-mean-square acceleration versus frequency, and power spectral density versus frequency versus time (spectrogram). Instructions for accessing NASA Lewis Research Center accelerometer data and related information using the internet are provided.

Topographic ERP analyses: a step-by-step tutorial review.

PubMed

Murray, Micah M; Brunet, Denis; Michel, Christoph M

2008-06-01

In this tutorial review, we detail both the rationale for as well as the implementation of a set of analyses of surface-recorded event-related potentials (ERPs) that uses the reference-free spatial (i.e. topographic) information available from high-density electrode montages to render statistical information concerning modulations in response strength, latency, and topography both between and within experimental conditions. In these and other ways these topographic analysis methods allow the experimenter to glean additional information and neurophysiologic interpretability beyond what is available from canonical waveform analyses. In this tutorial we present the example of somatosensory evoked potentials (SEPs) in response to stimulation of each hand to illustrate these points. For each step of these analyses, we provide the reader with both a conceptual and mathematical description of how the analysis is carried out, what it yields, and how to interpret its statistical outcome. We show that these topographic analysis methods are intuitive and easy-to-use approaches that can remove much of the guesswork often confronting ERP researchers and also assist in identifying the information contained within high-density ERP datasets.

Vocational students' learning preferences: the interpretability of ipsative data.

PubMed

Smith, P J

2000-02-01

A number of researchers have argued that ipsative data are not suitable for statistical procedures designed for normative data. Others have argued that the interpretability of such analyses of ipsative data are little affected where the number of variables and the sample size are sufficiently large. The research reported here represents a factor analysis of the scores on the Canfield Learning Styles Inventory for 1,252 students in vocational education. The results of the factor analysis of these ipsative data were examined in a context of existing theory and research on vocational students and lend support to the argument that the factor analysis of ipsative data can provide sensibly interpretable results.

Dual Treatments as Starting Point for Integrative Perceptions in Teaching Mathematics

ERIC Educational Resources Information Center

Kërënxhi, Svjetllana; Gjoci, Pranvera

2015-01-01

In this paper, we recommend mathematical teaching through dual treatments. The dual treatments notion, classified in dual interpretations, dual analyses, dual solutions, and dual formulations, is explained through concrete examples taken from mathematical textbooks of elementary education. Dual treatments provide opportunities for creating…

Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial

PubMed Central

Hallgren, Kevin A.

2012-01-01

Many research designs require the assessment of inter-rater reliability (IRR) to demonstrate consistency among observational ratings provided by multiple coders. However, many studies use incorrect statistical procedures, fail to fully report the information necessary to interpret their results, or do not address how IRR affects the power of their subsequent analyses for hypothesis testing. This paper provides an overview of methodological issues related to the assessment of IRR with a focus on study design, selection of appropriate statistics, and the computation, interpretation, and reporting of some commonly-used IRR statistics. Computational examples include SPSS and R syntax for computing Cohen’s kappa and intra-class correlations to assess IRR. PMID:22833776

Personality and job performance: the Big Five revisited.

PubMed

Hurtz, G M; Donovan, J J

2000-12-01

Prior meta-analyses investigating the relation between the Big 5 personality dimensions and job performance have all contained a threat to construct validity, in that much of the data included within these analyses was not derived from actual Big 5 measures. In addition, these reviews did not address the relations between the Big 5 and contextual performance. Therefore, the present study sought to provide a meta-analytic estimate of the criterion-related validity of explicit Big 5 measures for predicting job performance and contextual performance. The results for job performance closely paralleled 2 of the previous meta-analyses, whereas analyses with contextual performance showed more complex relations among the Big 5 and performance. A more critical interpretation of the Big 5-performance relationship is presented, and suggestions for future research aimed at enhancing the validity of personality predictors are provided.

Can Economic Model Transparency Improve Provider Interpretation of Cost-effectiveness Analysis? Evaluating Tradeoffs Presented by the Second Panel on Cost-effectiveness in Health and Medicine.

PubMed

Padula, William V; McQueen, Robert Brett; Pronovost, Peter J

2017-11-01

The Second Panel on Cost-Effectiveness in Health and Medicine convened on December 7, 2016 at the National Academy of Medicine to disseminate their recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses (CEAs). Following its summary, panel proceedings included lengthy discussions including the field's struggle to disseminate findings efficiently through peer-reviewed literature to target audiences. With editors of several medical and outcomes research journals in attendance, there was consensus that findings of cost-effectiveness analyses do not effectively reach other researchers or health care providers. The audience members suggested several solutions including providing additional training to clinicians in cost-effectiveness research and requiring that cost-effectiveness models are made publicly available. However, there remains the questions of whether making economic modelers' work open-access through journals is fair under the defense that these models remain one's own intellectual property, or whether journals can properly manage the peer-review process specifically for cost-effectiveness analyses. In this article, we elaborate on these issues and provide some suggested solutions that may increase the dissemination and application of cost-effectiveness literature to reach its intended audiences and ultimately benefit the patient. Ultimately, it is our combined view as economic modelers and clinicians that cost-effectiveness results need to reach the clinician to improve the efficiency of medical practice, but that open-access models do not improve clinician access or interpretation of the economics of medicine.

Strategic sensemaking and organizational performance: linkages among scanning, interpretation, action, and outcomes.

PubMed

Thomas, J B; Clark, S M; Gioia, D A

1993-04-01

This study investigated the strategic "sensemaking" processes of scanning, interpretation, and action and how those activities are linked to organizational performance. Using path analyses on data from 156 hospitals, we tested the direct and indirect effects among these sensemaking processes and performance outcomes and developed a model of their relationships. In a more general sense, the research represents an attempt to provide insight not only into relationships between cognition and action, but also into the links between those fundamental processes and organizational performance outcomes.

How to interpret a healthcare economic analysis.

PubMed

Brown, Melissa M; Brown, Gary C

2005-06-01

The purpose of the review is to present guidelines to help the clinician to interpret healthcare economic analyses and review pertinent recent analysis in the ophthalmic literature. There are four variants of healthcare economic analyses: (1) cost-minimization analysis; (2) cost-benefit analysis; (3) cost-effectiveness analysis and (4) cost-utility analysis. Cost-utility utility analysis has assumed an increasingly important role in healthcare, with increasing number of analyses occurring in the peer-reviewed ophthalmic literature. These include cost-utility analyses of cataract surgery in the first and second eyes, amblyopia treatment, and cost-utility analyses encompassing the vitreoretinal interventions of the following: (1) laser photocoagulation for exudative macular degeneration; (2) laser treatment for diabetic retinopathy; (3) laser photocoagulation for branch retinal vein obstruction; (4) diabetic vitrectomy; (5) treatment of proliferative retinopathy of prematurity and (6) treatment of retinal detachment associated with proliferative vitreoretinopathy. As an increasing number of cost-utility analyses become available they will provide the information system for the practice of value-based medicine, or medicine based upon the patient-perceived value conferred by interventions. Increasing numbers of cost-utility analysis in the ophthalmic literature suggest that ophthalmic interventions, including vitreoretinal interventions, are cost effective. Cost-utility analysis is a major tool in value-based medicine, the practice of medicine based upon the patient-perceived value conferred by healthcare interventions.

Parental experiences of providing skin-to-skin care to their newborn infant—Part 2: A qualitative meta-synthesis

PubMed Central

Anderzén-Carlsson, Agneta; Lamy, Zeni C.; Tingvall, Maria; Eriksson, Mats

2014-01-01

Aim To synthesize and interpret qualitative research findings focusing on parental experiences of skin-to-skin care (SSC) for newborn infants. Background SSC induces many benefits for newborn infants and their parents. Three meta-analyses have been conducted on physiological outcomes, but no previous qualitative meta-synthesis on parental experiences of SSC has been identified. Design The present meta-synthesis was guided by the methodology described by Paterson and co-workers. Data sources Four databases were searched, without year or language limitations, up until December 2013. Manual searches were also performed. The searches and subsequent quality appraisal resulted in the inclusion of 29 original qualitative papers from 9 countries, reporting experiences from 401 mothers and 94 fathers. Review methods The meta-synthesis entails a meta-data analysis, analysis of meta-method, and meta-theory in the included primary studies. Based on the three analyses, the meta-synthesis represents a new interpretation of a phenomenon. The results of the meta-data analysis have been presented as a qualitative systematic review in a separate paper. Results When synthesizing and interpreting the findings from the included analyses, a theoretical model of Becoming a parent under unfamiliar circumstances emerged. Providing SSC seems to be a restorative as well as an energy-draining experience. A supportive environment has been described as facilitating the restorative experience, whereas obstacles in the environment seem to make the provision of SSC energy-draining for parents. When the process is experienced as positive, it facilitates the growth of parental self-esteem and makes the parents ready to assume full responsibility for their child. Conclusion The results show that SSC can be interpreted not only as a family-including and important health care intervention but also in terms of actually becoming a parent. The process of becoming a parent in this specific situation is influenced by external factors in three different levels; family and friends, community, and society at large. The descriptions of providing SSC are similar to what has previously been described as the natural process of becoming a mother or a father. PMID:25319747

Parental experiences of providing skin-to-skin care to their newborn infant--part 2: a qualitative meta-synthesis.

PubMed

Anderzén-Carlsson, Agneta; Lamy, Zeni C; Tingvall, Maria; Eriksson, Mats

2014-01-01

To synthesize and interpret qualitative research findings focusing on parental experiences of skin-to-skin care (SSC) for newborn infants. SSC induces many benefits for newborn infants and their parents. Three meta-analyses have been conducted on physiological outcomes, but no previous qualitative meta-synthesis on parental experiences of SSC has been identified. The present meta-synthesis was guided by the methodology described by Paterson and co-workers. Four databases were searched, without year or language limitations, up until December 2013. Manual searches were also performed. The searches and subsequent quality appraisal resulted in the inclusion of 29 original qualitative papers from 9 countries, reporting experiences from 401 mothers and 94 fathers. The meta-synthesis entails a meta-data analysis, analysis of meta-method, and meta-theory in the included primary studies. Based on the three analyses, the meta-synthesis represents a new interpretation of a phenomenon. The results of the meta-data analysis have been presented as a qualitative systematic review in a separate paper. When synthesizing and interpreting the findings from the included analyses, a theoretical model of Becoming a parent under unfamiliar circumstances emerged. Providing SSC seems to be a restorative as well as an energy-draining experience. A supportive environment has been described as facilitating the restorative experience, whereas obstacles in the environment seem to make the provision of SSC energy-draining for parents. When the process is experienced as positive, it facilitates the growth of parental self-esteem and makes the parents ready to assume full responsibility for their child. The results show that SSC can be interpreted not only as a family-including and important health care intervention but also in terms of actually becoming a parent. The process of becoming a parent in this specific situation is influenced by external factors in three different levels; family and friends, community, and society at large. The descriptions of providing SSC are similar to what has previously been described as the natural process of becoming a mother or a father.

Interpretation of VLF-EM & VLF-R data using tipper and impedance analyses: A case study from Candi Umbul-Telomoyo, Magelang, Indonesia

NASA Astrophysics Data System (ADS)

Prastyani, Erina; Niasari, Sintia Windhi

2017-07-01

The goal of all geophysical survey techniques is to image the properties of the Earth's subsurface. Very Low Frequency (VLF) is one of the geophysical survey technique that has been commonly used for ore exploration and mapping faults or fracture zones. Faults or fracture zones are necessary components in providing the fluid pathway in geothermal systems. The Candi Umbul-Telomoyo is one of the geothermal prospect sites in Indonesia, which is located in Magelang, Central Java. Recent studies hypothesized that this site was an outflow area of Telomoyo volcano geothermal complex. We used the VLF-EM and VLF-R techniques to infer faults or fracture zones that might be a path for geothermal fluids in the Candi Umbul-Telomoyo. From the measurements, we got tilt angle, ellipticity, primary and secondary magnetic fieldfor VLF-EM data; and apparent resistivity, phase angle, electric and magnetic field for VLF-R data. To interpret the data, we used tipper and impedance analyses. The result of both analyses show similarities in the directions and positions of anomalous current concentrations. We conclude these anomalous current concentrations as faults. Our interpretation is agreeing with the Geologic Map of the Semarang and Magelang Quadrangles that shows the expected fault beneath the Mt. Telomoyo.

Evaluating Research Articles from Start to Finish.

ERIC Educational Resources Information Center

Girden, Ellen R.

This book in intended to train students in reading a research report critically. It uses actual research articles as examples including both good and flawed studies in each category and provides interpretation and evaluation of the appropriateness of the statistical analyses in each study. Individual chapters usually include two sample studies and…

Disrupting the Pipeline: Critical Analyses of Student Pathways through Postsecondary STEM Education

ERIC Educational Resources Information Center

Metcalf, Heather E.

2014-01-01

Critical mixed methods approaches allow us to reflect upon the ways in which we collect, measure, interpret, and analyze data, providing novel alternatives for quantitative analysis. For institutional researchers, whose work influences institutional policies, programs, and practices, the approach has the transformative ability to expose and create…

The Effects of Meal Schedule and Quantity on Problematic Behavior.

ERIC Educational Resources Information Center

Wacker, David P.; And Others

1996-01-01

Two case examples (a toddler with severe developmental delays and a 7-year old with severe mental retardation) illustrating effects of meal schedule and food quantity on displays of problematic behavior are offered. Brief functional analyses of aberrant behavior provided useful information for interpreting distinct patterns of behavior. (DB)

Pedagogy: East and West, Then and Now

ERIC Educational Resources Information Center

Cheng, Kai-Ming

2011-01-01

This is the first of six commentaries discussing Zongjie Wu's essay, "Interpretation, autonomy, and transformation". Wu's analyses of pedagogy have opened a new window for looking at the essence of education. The comparison of Confucius's pedagogy with contemporary teaching in China provides a striking contrast. However, perhaps it is…

Practice of Nursing Care Provided to Clients from Muslim Countries in the Czech Republic.

PubMed

Janků, Tomáš; Linhartová, Lenka; Topinka, Daniel

2017-10-01

Authors deal with practice of nursing care provided to Muslim clients in the Czech Republic. They use the explorative research design. By means of analyses of 21 semi-structured interviews with important social actors in the area of health care (spa resorts and hospitals). The study shows that Muslims are not homogeneous in their behaviour in the field of health care. In the spa environment, three interpretation perspectives can be found: the economic interpretation of a Muslim as the source of income of the Czech spa industry, which faces economic problems, the cultural interpretation developed within the spas (the experience capital of the staff and other clients), and the (a) cultural interpretation of Muslims and Islam brought to spas from the outside (the public opinion). However, in the area of hospitals, Muslims are not separated from the remaining categories of students; Muslim patients represent a small group of persons, and their treatment being conditioned by the distance or closeness of cultures, language skills, adaptation, and experiences with treatment in the Czech environment as perceived by the staff.

Power System Oscillatory Behaviors: Sources, Characteristics, & Analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Follum, James D.; Tuffner, Francis K.; Dosiek, Luke A.

This document is intended to provide a broad overview of the sources, characteristics, and analyses of natural and forced oscillatory behaviors in power systems. These aspects are necessarily linked. Oscillations appear in measurements with distinguishing characteristics derived from the oscillation’s source. These characteristics determine which analysis methods can be appropriately applied, and the results from these analyses can only be interpreted correctly with an understanding of the oscillation’s origin. To describe oscillations both at their source within a physical power system and within measurements, a perspective from the boundary between power system and signal processing theory has been adopted.

How individual participant data meta-analyses have influenced trial design, conduct, and analysis.

PubMed

Tierney, Jayne F; Pignon, Jean-Pierre; Gueffyier, Francois; Clarke, Mike; Askie, Lisa; Vale, Claire L; Burdett, Sarah

2015-11-01

To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses and knowledge of trials in their respective clinical areas. Experts in the field who did not attend were asked to provide any further examples. We then examined relevant trial protocols, publications, and Web sites to verify the impacts of the IPD meta-analyses. A subgroup of workshop attendees sought further examples and identified other aspects of trial design and conduct that may inform IPD meta-analyses. We identified 52 examples of IPD meta-analyses thought to have had a direct impact on the design or conduct of trials. After screening relevant trial protocols and publications, we identified 28 instances where IPD meta-analyses had clearly impacted on trials. They have influenced the selection of comparators and participants, sample size calculations, analysis and interpretation of subsequent trials, and the conduct and analysis of ongoing trials, sometimes in ways that would not possible with systematic reviews of aggregate data. We identified additional potential ways that IPD meta-analyses could be used to influence trials. IPD meta-analysis could be better used to inform the design, conduct, analysis, and interpretation of trials. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

How individual participant data meta-analyses have influenced trial design, conduct, and analysis

PubMed Central

Tierney, Jayne F.; Pignon, Jean-Pierre; Gueffyier, Francois; Clarke, Mike; Askie, Lisa; Vale, Claire L.; Burdett, Sarah; Alderson, P.; Askie, L.; Bennett, D.; Burdett, S.; Clarke, M.; Dias, S.; Emberson, J.; Gueyffier, F.; Iorio, A.; Macleod, M.; Mol, B.W.; Moons, C.; Parmar, M.; Perera, R.; Phillips, R.; Pignon, J.P.; Rees, J.; Reitsma, H.; Riley, R.; Rovers, M.; Rydzewska, L.; Schmid, C.; Shepperd, S.; Stenning, S.; Stewart, L.; Tierney, J.; Tudur Smith, C.; Vale, C.; Welge, J.; White, I.; Whiteley, W.

2015-01-01

Objectives To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. Study Design and Setting Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses and knowledge of trials in their respective clinical areas. Experts in the field who did not attend were asked to provide any further examples. We then examined relevant trial protocols, publications, and Web sites to verify the impacts of the IPD meta-analyses. A subgroup of workshop attendees sought further examples and identified other aspects of trial design and conduct that may inform IPD meta-analyses. Results We identified 52 examples of IPD meta-analyses thought to have had a direct impact on the design or conduct of trials. After screening relevant trial protocols and publications, we identified 28 instances where IPD meta-analyses had clearly impacted on trials. They have influenced the selection of comparators and participants, sample size calculations, analysis and interpretation of subsequent trials, and the conduct and analysis of ongoing trials, sometimes in ways that would not possible with systematic reviews of aggregate data. We identified additional potential ways that IPD meta-analyses could be used to influence trials. Conclusions IPD meta-analysis could be better used to inform the design, conduct, analysis, and interpretation of trials. PMID:26186982

Blood analyses of wolf pups and their ecological and metabolic interpretation

USGS Publications Warehouse

Seal, U.S.; Mech, L.D.; Van Ballenberghe, V.

1975-01-01

Blood samples were obtained from 32 wolf (Canis lupus) pups live-trapped over a three-year period in northern Minnesota. The results of 21 laboratory analyses of hematology and blood chemistry are tabulated and analyzed in terms of study area, age, sex, and year of co11ection. Mean values are compared to those reported for dogs in the same age group. The numerous differences between dog and wolf pups are interpreted in terms of nutritional levels and dietary composition with the suggestion that the wolves are not achieving their full growth potential. Individual abnormal test results are tabulated and possible interpretations are suggested. Abnormal results were observed in 13 animals including 10 of 11 animals sampled in 1972. The results in the 1972 animals indicated a poorer nutrition. This preponderance of abnormal test results in pups from 1972 is correlated with ecological studies on this wolf population indicating decreased survival. The potential value of such long-term integrated field and laboratory studies for providing a more complete understanding of changes in the dynamics of natural populations in terms of the responses of individual animals is demonstrated.

Interpretation of searches for supersymmetry with simplified models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.

The results of searches for supersymmetry by the CMS experiment are interpreted in the framework of simplified models. The results are based on data corresponding to an integrated luminosity of 4.73 to 4.98 inverse femtobarns. The data were collected at the LHC in proton-proton collisions at a center-of-mass energy of 7 TeV. This paper describes the method of interpretation and provides upper limits on the product of the production cross section and branching fraction as a function of new particle masses for a number of simplified models. These limits and the corresponding experimental acceptance calculations can be used to constrainmore » other theoretical models and to compare different supersymmetry-inspired analyses.« less

Biological data for water in Lake Powell and from Glen Canyon Dam releases, Utah and Arizona, 1990–2009

USGS Publications Warehouse

Vernieu, William S.

2015-10-06

The results of these analyses are presented in this report. From this record, further interpretation may be made concerning primary and secondary production in Lake Powell. These data provide a linkage between physical and chemical water-quality data and fisheries investigations in Lake Powell. They also provide information regarding the export of biological material from Glen Canyon Dam.

Genome build information is an essential part of genomic track files.

PubMed

Kanduri, Chakravarthi; Domanska, Diana; Hovig, Eivind; Sandve, Geir Kjetil

2017-09-14

Genomic locations are represented as coordinates on a specific genome build version, but the build information is frequently missing when coordinates are provided. We show that this information is essential to correctly interpret and analyse the genomic intervals contained in genomic track files. Although not a substitute for best practices, we also provide a tool to predict the genome build version of genomic track files.

Using Meta-analyses for Comparative Effectiveness Research

PubMed Central

Ruppar, Todd M.; Phillips, Lorraine J.; Chase, Jo-Ana D.

2012-01-01

Comparative effectiveness research seeks to identify the most effective interventions for particular patient populations. Meta-analysis is an especially valuable form of comparative effectiveness research because it emphasizes the magnitude of intervention effects rather than relying on tests of statistical significance among primary studies. Overall effects can be calculated for diverse clinical and patient-centered variables to determine the outcome patterns. Moderator analyses compare intervention characteristics among primary studies by determining if effect sizes vary among studies with different intervention characteristics. Intervention effectiveness can be linked to patient characteristics to provide evidence for patient-centered care. Moderator analyses often answer questions never posed by primary studies because neither multiple intervention characteristics nor populations are compared in single primary studies. Thus meta-analyses provide unique contributions to knowledge. Although meta-analysis is a powerful comparative effectiveness strategy, methodological challenges and limitations in primary research must be acknowledged to interpret findings. PMID:22789450

The Use of Structure Coefficients to Address Multicollinearity in Sport and Exercise Science

ERIC Educational Resources Information Center

Yeatts, Paul E.; Barton, Mitch; Henson, Robin K.; Martin, Scott B.

2017-01-01

A common practice in general linear model (GLM) analyses is to interpret regression coefficients (e.g., standardized ß weights) as indicators of variable importance. However, focusing solely on standardized beta weights may provide limited or erroneous information. For example, ß weights become increasingly unreliable when predictor variables are…

Faith in Welfare: The Origins of the Open Home Foundation

ERIC Educational Resources Information Center

Troughton, Geoffrey

2013-01-01

This article analyses the origins of the Open Home Foundation (OHF), a Christian social service provider that commenced in New Zealand in 1977. It interprets the Foundation's appeal, paying particular attention to the role of religious values and spirituality within the organisation. The article argues that OHF emerged and flourished from the late…

Genomics and the challenging translation into conservation practice

Treesearch

Aaron B. A. Shafer; Jochen B. W. Wolf; Paulo C. Alves; Linnea Bergstrom; Michael W. Bruford; Ioana Brannstrom; Guy Colling; Love Dalen; Luc De Meester; Robert Ekblom; Katie D. Fawcett; Simone Fior; Mehrdad Hajibabaei; Jason A. Hill; A. Rus Hoezel; Jacob Hoglund; Evelyn L. Jensen; Johannes Krause; Torsten N. Kristensen; Michael Krutzen; John K. McKay; Anita J. Norman; Rob Ogden; E. Martin Osterling; N. Joop Ouborg; John Piccolo; Danijela Popovic; Craig R. Primmer; Floyd A. Reed; Marie Roumet; Jordi Salmona; Tamara Schenekar; Michael K. Schwartz; Gernot Segelbacher; Helen Senn; Jens Thaulow; Mia Valtonen; Andrew Veale; Philippine Vergeer; Nagarjun Vijay; Carles Vila; Matthias Weissensteiner; Lovisa Wennerstrom; Christopher W. Wheat; Piotr Zielinski

2015-01-01

The global loss of biodiversity continues at an alarming rate. Genomic approaches have been suggested as a promising tool for conservation practice as scaling up to genome-wide data can improve traditional conservation genetic inferences and provide qualitatively novel insights. However, the generation of genomic data and subsequent analyses and interpretations remain...

A Proposed Model of Retransformed Qualitative Data within a Mixed Methods Research Design

ERIC Educational Resources Information Center

Palladino, John M.

2009-01-01

Most models of mixed methods research design provide equal emphasis of qualitative and quantitative data analyses and interpretation. Other models stress one method more than the other. The present article is a discourse about the investigator's decision to employ a mixed method design to examine special education teachers' advocacy and…

Geological sampling data and benthic biota classification: Buzzards Bay and Vineyard Sound, Massachusetts

USGS Publications Warehouse

Ackerman, Seth D.; Pappal, Adrienne L.; Huntley, Emily C.; Blackwood, Dann S.; Schwab, William C.

2015-01-01

Sea-floor sample collection is an important component of a statewide cooperative mapping effort between the U.S. Geological Survey (USGS) and the Massachusetts Office of Coastal Zone Management (CZM). Sediment grab samples, bottom photographs, and video transects were collected within Vineyard Sound and Buzzards Bay in 2010 aboard the research vesselConnecticut. This report contains sample data and related information, including analyses of surficial-sediment grab samples, locations and images of sea-floor photography, survey lines along which sea-floor video was collected, and a classification of benthic biota observed in sea-floor photographs and based on the Coastal and Marine Ecological Classification Standard (CMECS). These sample data and analyses information are used to verify interpretations of geophysical data and are an essential part of geologic maps of the sea floor. These data also provide a valuable inventory of benthic habitat and resources. Geographic information system (GIS) data, maps, and interpretations, produced through the USGS and CZM mapping cooperative, are intended to aid efforts to manage coastal and marine resources and to provide baseline information for research focused on coastal evolution and environmental change.

Application of multivariate statistical techniques in microbial ecology.

PubMed

Paliy, O; Shankar, V

2016-03-01

Recent advances in high-throughput methods of molecular analyses have led to an explosion of studies generating large-scale ecological data sets. In particular, noticeable effect has been attained in the field of microbial ecology, where new experimental approaches provided in-depth assessments of the composition, functions and dynamic changes of complex microbial communities. Because even a single high-throughput experiment produces large amount of data, powerful statistical techniques of multivariate analysis are well suited to analyse and interpret these data sets. Many different multivariate techniques are available, and often it is not clear which method should be applied to a particular data set. In this review, we describe and compare the most widely used multivariate statistical techniques including exploratory, interpretive and discriminatory procedures. We consider several important limitations and assumptions of these methods, and we present examples of how these approaches have been utilized in recent studies to provide insight into the ecology of the microbial world. Finally, we offer suggestions for the selection of appropriate methods based on the research question and data set structure. © 2016 John Wiley & Sons Ltd.

Multicollinearity in spatial genetics: separating the wheat from the chaff using commonality analyses.

PubMed

Prunier, J G; Colyn, M; Legendre, X; Nimon, K F; Flamand, M C

2015-01-01

Direct gradient analyses in spatial genetics provide unique opportunities to describe the inherent complexity of genetic variation in wildlife species and are the object of many methodological developments. However, multicollinearity among explanatory variables is a systemic issue in multivariate regression analyses and is likely to cause serious difficulties in properly interpreting results of direct gradient analyses, with the risk of erroneous conclusions, misdirected research and inefficient or counterproductive conservation measures. Using simulated data sets along with linear and logistic regressions on distance matrices, we illustrate how commonality analysis (CA), a detailed variance-partitioning procedure that was recently introduced in the field of ecology, can be used to deal with nonindependence among spatial predictors. By decomposing model fit indices into unique and common (or shared) variance components, CA allows identifying the location and magnitude of multicollinearity, revealing spurious correlations and thus thoroughly improving the interpretation of multivariate regressions. Despite a few inherent limitations, especially in the case of resistance model optimization, this review highlights the great potential of CA to account for complex multicollinearity patterns in spatial genetics and identifies future applications and lines of research. We strongly urge spatial geneticists to systematically investigate commonalities when performing direct gradient analyses. © 2014 John Wiley & Sons Ltd.

Investigation of the mechanical behaviour of the foot skin.

PubMed

Fontanella, C G; Carniel, E L; Forestiero, A; Natali, A N

2014-11-01

The aim of this work was to provide computational tools for the characterization of the actual mechanical behaviour of foot skin, accounting for results from experimental testing and histological investigation. Such results show the typical features of skin mechanics, such as anisotropic configuration, almost incompressible behaviour, material and geometrical non linearity. The anisotropic behaviour is mainly determined by the distribution of collagen fibres along specific directions, usually identified as cleavage lines. To evaluate the biomechanical response of foot skin, a refined numerical model of the foot is developed. The overall mechanical behaviour of the skin is interpreted by a fibre-reinforced hyperelastic constitutive model and the orientation of the cleavage lines is implemented by a specific procedure. Numerical analyses that interpret typical loading conditions of the foot are performed. The influence of fibres orientation and distribution on skin mechanics is outlined also by a comparison with results using an isotropic scheme. A specific constitutive formulation is provided to characterize the mechanical behaviour of foot skin. The formulation is applied within a numerical model of the foot to investigate the skin functionality during typical foot movements. Numerical analyses developed accounting for the actual anisotropic configuration of the skin show lower maximum principal stress fields than results from isotropic analyses. The developed computational models provide reliable tools for the investigation of foot tissues functionality. Furthermore, the comparison between numerical results from anisotropic and isotropic models shows the optimal configuration of foot skin. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation.

PubMed

Pesaran, Bijan; Vinck, Martin; Einevoll, Gaute T; Sirota, Anton; Fries, Pascal; Siegel, Markus; Truccolo, Wilson; Schroeder, Charles E; Srinivasan, Ramesh

2018-06-25

New technologies to record electrical activity from the brain on a massive scale offer tremendous opportunities for discovery. Electrical measurements of large-scale brain dynamics, termed field potentials, are especially important to understanding and treating the human brain. Here, our goal is to provide best practices on how field potential recordings (electroencephalograms, magnetoencephalograms, electrocorticograms and local field potentials) can be analyzed to identify large-scale brain dynamics, and to highlight critical issues and limitations of interpretation in current work. We focus our discussion of analyses around the broad themes of activation, correlation, communication and coding. We provide recommendations for interpreting the data using forward and inverse models. The forward model describes how field potentials are generated by the activity of populations of neurons. The inverse model describes how to infer the activity of populations of neurons from field potential recordings. A recurring theme is the challenge of understanding how field potentials reflect neuronal population activity given the complexity of the underlying brain systems.

Fundamental principles of conducting a surgery economic analysis study.

PubMed

Kotsis, Sandra V; Chung, Kevin C

2010-02-01

The use of economic evaluation in surgery is scarce. Economic evaluation is used even less so in plastic surgery, in which health-related quality of life is of particular importance. This article, part of a tutorial series on evidence-based medicine, focuses on the fundamental principles of conducting a surgery economic analysis. The authors include the essential aspects of conducting a surgical cost-utility analysis by considering perspectives, costs, outcomes, and utilities. The authors also describe and give examples of how to conduct the analyses (including calculating quality-adjusted life-years and discounting), how to interpret the results, and how to report the results. Although economic analyses are not simple to conduct, a well-conducted one provides many rewards, such as recommending the adoption of a more effective treatment. For comparing and interpreting economic analysis publications, it is important that all studies use consistent methodology and report the results in a similar manner.

Water in exoplanets.

PubMed

Tinetti, Giovanna; Tennyson, Jonathan; Griffith, Caitlin A; Waldmann, Ingo

2012-06-13

Exoplanets--planets orbiting around stars other than our own Sun--appear to be common. Significant research effort is now focused on the observation and characterization of exoplanet atmospheres. Species such as water vapour, methane, carbon monoxide and carbon dioxide have been observed in a handful of hot, giant, gaseous planets, but cooler, smaller planets such as Gliese 1214b are now analysable with current telescopes. Water is the key chemical dictating habitability. The current observations of water in exoplanets from both space and the ground are reviewed. Controversies surrounding the interpretation of these observations are discussed. Detailed consideration of available radiative transfer models and linelists are used to analyse these differences in interpretation. Models suggest that there is a clear need for data on the pressure broadening of water transitions by H(2) at high temperatures. The reported detections of water appear to be robust, although final confirmation will have to await the better quality observational data provided by currently planned dedicated space missions.

OMEGA: A NEW COLD X-RAY SIMULATION FACILITY FOR THE EVALUATION OF OPTICAL COATINGS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher, J H; Newlander, C D; Fournier, K B

We report on recent progress for the development of a new cold X-ray optical test capability using the Omega Facility located at the Laboratory for Laser Energetics (LLE) at the University of Rochester. These tests were done on the 30 kJ OMEGA laser at the Laboratory for Laser Energetics (LLE) at the University of Rochester, Rochester, NY. We conducted a six-shot series called OMEGA II on 14 July 2006 in one eight-hour day (supported by the Defense Threat Reduction Agency). The initial testing was performed using simple protected gold optical coatings on fused silica substrates. PUFFTFT analyses were completed andmore » the specimen's thermal lateral stress and transverse stress conditions were calculated and interpreted. No major anomalies were detected. Comparison of the pre- and posttest reflective measurements coupled with the TFCALC analyses proved invaluable in guiding the analyses and interpreting the observed damage. The Omega facility is a high quality facility for performing evaluation of optical coatings and coupons and provides experience for the development of future National Ignition Facility (NIF) testing.« less

Field and laboratory analyses of water from the Columbia aquifer in Eastern Maryland

USGS Publications Warehouse

Bachman, L.J.

1984-01-01

Field and laboratory analyses of pH, alkalinity, and specific conductance from water samples collected from the Columbia aquifer on the Delmarva Peninsula in eastern Maryland were compared to determine if laboratory analyses could be used for making regional water-quality interpretations. Kruskal-Wallis tests of field and laboratory data indicate that the difference between field and laboratory values is usually not enough to affect the outcome of the statistical tests. Thus, laboratory measurements of these constituents may be adequate for making certain regional water-quality interpretations, although they may result in errors if used for geochemical interpretations.

The characteristics and interpretability of land surface change and implications for project design

USGS Publications Warehouse

Sohl, Terry L.; Gallant, Alisa L.; Loveland, Thomas R.

2004-01-01

The need for comprehensive, accurate information on land-cover change has never been greater. While remotely sensed imagery affords the opportunity to provide information on land-cover change over large geographic expanses at a relatively low cost, the characteristics of land-surface change bring into question the suitability of many commonly used methodologies. Algorithm-based methodologies to detect change generally cannot provide the same level of accuracy as the analyses done by human interpreters. Results from the Land Cover Trends project, a cooperative venture that includes the U.S. Geological Survey, Environmental Protection Agency, and National Aeronautics and Space Administration, have shown that land-cover conversion is a relatively rare event, occurs locally in small patches, varies geographically and temporally, and is spectrally ambiguous. Based on these characteristics of change and the type of information required, manual interpretation was selected as the primary means of detecting change in the Land Cover Trends project. Mixtures of algorithm-based detection and manual interpretation may often prove to be the most feasible and appropriate design for change-detection applications. Serious examination of the expected characteristics and measurability of change must be considered during the design and implementation phase of any change analysis project.

Convenient Access to Professional Interpreters in the Hospital Decreases Readmission Rates and Estimated Hospital Expenditures for Patients With Limited English Proficiency.

PubMed

Karliner, Leah S; Pérez-Stable, Eliseo J; Gregorich, Steven E

2017-03-01

Twenty-five million people in the United States have limited English proficiency (LEP); this growing and aging population experiences worse outcomes when hospitalized. Federal requirements that hospitals provide language access services are very challenging to implement in the fast-paced, 24-hour hospital environment. To determine if increasing access to professional interpreters improves hospital outcomes for older patients with LEP. Natural experiment on a medicine floor of an academic hospital. Patients age 50 years or above discharged between January 15, 2007 and January 15, 2010. Dual-handset interpreter telephone at every bedside July 15, 2008 to Mar 14, 2009. Thirty-day readmission, length of stay, estimated hospital expenditures. Of 8077 discharges, 1963 were for LEP, and 6114 for English proficient patients. There was a significant decrease in observed 30-day readmission rates for the LEP group during the 8-month intervention period compared with 18 months preintervention (17.8% vs. 13.4%); at the same time English proficient readmission rates increased (16.7% vs. 19.7%); results remained significant in adjusted analyses. This improved readmission outcome for the LEP group was not maintained during the subsequent postintervention period when the telephones became less accessible. There was no significant intervention impact on length of stay in either unadjusted or adjusted analyses. After accounting for interpreter services costs, the estimated 119 readmissions averted during the intervention period were associated with estimated monthly hospital expenditure savings of $161,404. Comprehensive language access represents an important, high value service that all medical centers should provide to achieve equitable, quality healthcare for vulnerable LEP populations.

Convenient Access to Professional Interpreters in the Hospital Decreases Readmission Rates and Estimated Hospital Expenditures for Patients with Limited English Proficiency

PubMed Central

Karliner, Leah S.; Pérez-Stable, Eliseo J.; Gregorich, Steven E.

2016-01-01

Background Twenty-five million people in the U.S. have limited English proficiency (LEP); this growing and aging population experiences worse outcomes when hospitalized. Federal requirements that hospitals provide language access services are very challenging to implement in the fast-paced, 24-hour hospital environment. Objective Determine if increasing access to professional interpreters improves hospital outcomes for older patients with LEP Design Natural experiment on a medicine floor of an academic hospital Participants Patients age ≥50 discharged between Jan 15, 2007–Jan 15, 2010. Exposure Dual-handset interpreter telephone at every bedside July 15, 2008–Mar 14, 2009 Outcome Measures 30-day readmission, length of stay (LOS), estimated hospital expenditures Results Of 8,077 discharges, 1,963 were for LEP, and 6,114 for English-proficient (EP) patients. There was a significant decrease in observed 30-day readmission rates for the LEP group during the 8-month intervention period compared to 18 months pre-intervention (17.8% vs. 13.4%); at the same time EP readmission rates increased (16.7% vs. 19.7%); results remained significant in adjusted analyses. This improved readmission outcome for the LEP group was not maintained during the subsequent post-intervention period when the telephones became less accessible. There was no significant intervention impact on LOS in either unadjusted or adjusted analyses. After accounting for interpreter services costs, the estimated 119 readmissions averted during the intervention period were associated with estimated monthly hospital expenditure savings of $161,404. Conclusions Comprehensive language access represents an important, high value service that all medical centers should provide in order to achieve equitable, quality healthcare for vulnerable LEP populations. PMID:27579909

Higher Education Policies in Mexico in the 1990s: A Critical Balance

ERIC Educational Resources Information Center

Rodriguez-Gomez, Roberto; Casanova-Cardiel, Hugo

2005-01-01

This article analyses recent policies in higher education in Mexico. The last two decades provide the starting point, and the interpretation centres around higher education policies drawn up by successive presidential administrations of Salinas de Gortari (1988-1994) and Zedillo Ponce de Leon (1994-2000). The second part sets out an initial…

Peer Feedback in Second Language Writing (2005-2014)

ERIC Educational Resources Information Center

Yu, Shulin; Lee, Icy

2016-01-01

This article reviews research on peer feedback in second language (L2) writing published in the last decade (i.e. 2005-2014). We analyse first the theoretical underpinnings that have informed both peer feedback research and the pedagogical use of peer feedback in L2 writing instruction. We also provide a critical interpretation of existing peer…

Providing Choice in Middle Grade Classrooms: An Exploratory Study of Enactment Variability and Student Reflection

ERIC Educational Resources Information Center

Williams, Jasmine D.; Wallace, Tanner LeBaron; Sung, Hannah C.

2016-01-01

Employing descriptive and interpretive analyses of classroom videos and focus group data, this study details how the provision of choice was enacted in instruction, and the subsequent messages students perceived. Participants included six teachers (fourth to eighth grade) and 114 students (age X-bar = 11.28 years, 60% African American). Survey…

Implementation of School Choice Policy: Interpretation and Response by Parents of Students with Special Educational Needs.

ERIC Educational Resources Information Center

Bagley, Carl; Woods, Philip A.; Woods, Glenys

2001-01-01

Provides empirically based insights into preferences, perceptions, and responses of parents of students with special education needs to the 1990s restructured school system in England. Uses analyses of quantitative/qualitative data generated by a large-scale research study on school choice. Reveals depth and range of problems encountered by these…

Psychometric properties of the Epworth Sleepiness Scale: A factor analysis and item-response theory approach.

PubMed

Pilcher, June J; Switzer, Fred S; Munc, Alec; Donnelly, Janet; Jellen, Julia C; Lamm, Claus

2018-04-01

The purpose of this study is to examine the psychometric properties of the Epworth Sleepiness Scale (ESS) in two languages, German and English. Students from a university in Austria (N = 292; 55 males; mean age = 18.71 ± 1.71 years; 237 females; mean age = 18.24 ± 0.88 years) and a university in the US (N = 329; 128 males; mean age = 18.71 ± 0.88 years; 201 females; mean age = 21.59 ± 2.27 years) completed the ESS. An exploratory-factor analysis was completed to examine dimensionality of the ESS. Item response theory (IRT) analyses were used to provide information about the response rates on the items on the ESS and provide differential item functioning (DIF) analyses to examine whether the items were interpreted differently between the two languages. The factor analyses suggest that the ESS measures two distinct sleepiness constructs. These constructs indicate that the ESS is probing sleepiness in settings requiring active versus passive responding. The IRT analyses found that overall, the items on the ESS perform well as a measure of sleepiness. However, Item 8 and to a lesser extent Item 6 were being interpreted differently by respondents in comparison to the other items. In addition, the DIF analyses showed that the responses between German and English were very similar indicating that there are only minor measurement differences between the two language versions of the ESS. These findings suggest that the ESS provides a reliable measure of propensity to sleepiness; however, it does convey a two-factor approach to sleepiness. Researchers and clinicians can use the German and English versions of the ESS but may wish to exclude Item 8 when calculating a total sleepiness score.

Modifying interpretation biases in body dysmorphic disorder: Evaluation of a brief computerized treatment.

PubMed

Summers, Berta J; Cougle, Jesse R

2016-12-01

Individuals meeting diagnostic criteria for body dysmorphic disorder (BDD; N = 40) were enrolled in a randomized, four-session trial comparing interpretation bias modification (IBM) training designed to target social evaluation- and appearance-related interpretation biases with a placebo control training condition (PC). Sessions took place over the course of two weeks (two sessions per week). Analyses indicated that, relative to the PC condition, IBM led to a significant increase in benign biases and reduction in threat biases at post-treatment. IBM also led to greater reductions in BDD symptoms compared to PC, though this effect was present at high but not low levels of pre-treatment BDD symptoms. Additionally, compared to PC, IBM led to lower urge to check and lower fear in response to an in vivo appearance-related stressor (having their picture taken from different angles), though the latter effect was present only among those reporting elevated fear at pre-treatment. The effects of treatment on interpretation biases and BDD symptoms were largely maintained at a one-month follow-up assessment. Moderated-mediation analyses showed that change in threat bias mediated the effect of condition on post-treatment symptoms for individuals high in pre-treatment BDD symptoms. The current study provides preliminary support for the efficacy of IBM for BDD. Copyright © 2016 Elsevier Ltd. All rights reserved.

Social inequality, lifestyles and health - a non-linear canonical correlation analysis based on the approach of Pierre Bourdieu.

PubMed

Grosse Frie, Kirstin; Janssen, Christian

2009-01-01

Based on the theoretical and empirical approach of Pierre Bourdieu, a multivariate non-linear method is introduced as an alternative way to analyse the complex relationships between social determinants and health. The analysis is based on face-to-face interviews with 695 randomly selected respondents aged 30 to 59. Variables regarding socio-economic status, life circumstances, lifestyles, health-related behaviour and health were chosen for the analysis. In order to determine whether the respondents can be differentiated and described based on these variables, a non-linear canonical correlation analysis (OVERALS) was performed. The results can be described on three dimensions; Eigenvalues add up to the fit of 1.444, which can be interpreted as approximately 50 % of explained variance. The three-dimensional space illustrates correspondences between variables and provides a framework for interpretation based on latent dimensions, which can be described by age, education, income and gender. Using non-linear canonical correlation analysis, health characteristics can be analysed in conjunction with socio-economic conditions and lifestyles. Based on Bourdieus theoretical approach, the complex correlations between these variables can be more substantially interpreted and presented.

Non-Western interpreters' experiences of trauma: the protective role of culture following exposure to oppression.

PubMed

Johnson, Howard; Thompson, Andrew; Downs, Maria

2009-08-01

Many people flee their countries of origin after suffering severe trauma and there is a need to explore how socio-cultural factors are implicated in the experience of both trauma and posttraumatic growth. Interpreters who have been through a trauma are in a unique position to be able to reflect on cultural context. This study explored how interpreters working in the UK who had formerly suffered trauma in their country of origin, and who identified themselves as coping well, managed their experience of trauma. The qualitative method Interpretative Phenomenological Analysis (IPA) was used. Nine interpreters were interviewed following a semi-structured guide and the resulting transcripts were analysed according to IPA principles. Three key themes emerged from the data that were labelled as: trauma in the context of wider shared oppression; resisting and responding; and cultural protection and growth. Many participants described their lives prior to arriving in the UK as involving a collective traumatisation as a result of being a victim of oppression related to their cultural identity. The participants described the importance of staying connected to their culture. Giving and providing social support, religious practices, and the role of interpreter facilitated remaining connected. A sense of shared victimisation provided a protective backdrop from which the participants could make sense of the personal traumas they had experienced. The role of interpreting was important as it helped maintain cultural identity. The findings are discussed in relation to theories of both PTSD and Posttraumatic Growth. The results have implications for the work of clinicians supporting non-Western people who have been traumatised.

Using narrative pedagogy: learning and practising interpretive thinking.

PubMed

Ironside, Pamela M

2006-08-01

This paper reports a hermeneutic study undertaken to explicate students' experiences in educational courses in which teachers enact Narrative Pedagogy. International interest in developing and implementing discipline-specific pedagogies is becoming commonplace as teachers respond to the challenges of preparing students for contemporary practice. Lifeworld Pedagogy, developed in Scandinavia, and Narrative Pedagogy, developed in the United States of America, Canada and New Zealand, are two approaches developed from nursing research for nursing education that provide teachers with research-based alternatives to conventional pedagogy. Further research is needed, however, that addresses how new pedagogies are experienced in schools of nursing. Teachers and students from 22 schools of nursing in the United States of America were interviewed over a 4-year period between 2002 and 2005. Using interpretive phenomenology as the philosophical background and Heideggerian hermeneutics as the method, accounts from 52 participants were analysed by a research team. The theme Learning and Practising Interpretive Thinking reveals how reform is occurring in schools of nursing that use Narrative Pedagogy. It documents how Narrative Pedagogy helps students challenge their assumptions and think through and interpret situations they encounter from multiple perspectives. Findings suggest that by focusing teachers' and students' attention on thinking and interpreting as communal experiences, interpretive pedagogies such as Narrative Pedagogy engage teachers and students in pooling their wisdom, challenging their preconceptions, envisioning new possibilities for providing care and engaging with others to ensure patient-centred care and safety. By documenting students' experiences in courses in which Narrative Pedagogy is used, this study provides teachers with research-based evidence to guide their pedagogical decisions. It extends international efforts to develop discipline-specific pedagogies and offers a practical, student-centred approach teachers can use to enhance students' thinking.

Assessing compositional variability through graphical analysis and Bayesian statistical approaches: case studies on transgenic crops.

PubMed

Harrigan, George G; Harrison, Jay M

2012-01-01

New transgenic (GM) crops are subjected to extensive safety assessments that include compositional comparisons with conventional counterparts as a cornerstone of the process. The influence of germplasm, location, environment, and agronomic treatments on compositional variability is, however, often obscured in these pair-wise comparisons. Furthermore, classical statistical significance testing can often provide an incomplete and over-simplified summary of highly responsive variables such as crop composition. In order to more clearly describe the influence of the numerous sources of compositional variation we present an introduction to two alternative but complementary approaches to data analysis and interpretation. These include i) exploratory data analysis (EDA) with its emphasis on visualization and graphics-based approaches and ii) Bayesian statistical methodology that provides easily interpretable and meaningful evaluations of data in terms of probability distributions. The EDA case-studies include analyses of herbicide-tolerant GM soybean and insect-protected GM maize and soybean. Bayesian approaches are presented in an analysis of herbicide-tolerant GM soybean. Advantages of these approaches over classical frequentist significance testing include the more direct interpretation of results in terms of probabilities pertaining to quantities of interest and no confusion over the application of corrections for multiple comparisons. It is concluded that a standardized framework for these methodologies could provide specific advantages through enhanced clarity of presentation and interpretation in comparative assessments of crop composition.

Structure and Filling Characteristics of Paleokarst Reservoirs in the Northern Tarim Basin, Revealed by Outcrop, Core and Borehole Images

NASA Astrophysics Data System (ADS)

Tian, Fei; Lu, Xinbian; Zheng, Songqing; Zhang, Hongfang; Rong, Yuanshuai; Yang, Debin; Liu, Naigui

2017-06-01

The Ordovician paleokarst reservoirs in the Tahe oilfield, with burial depths of over 5300 m, experienced multiple phases of geologic processes and exhibit strong heterogeneity. Core testing can be used to analyse the characteristics of typical points at the centimetre scale, and seismic datasets can reveal the macroscopic outlines of reservoirs at the >10-m scale. However, neither method can identify caves, cave fills and fractures at the meter scale. Guided by outcrop investigations and calibrations based on core sample observations, this paper describes the interpretation of high longitudinal resolution borehole images, the identification of the characteristics of caves, cave fills (sedimentary, breccia and chemical fills) and fractures in single wells, and the identification of structures and fill characteristics at the meter scale in the strongly heterogeneous paleokarst reservoirs. The paleogeomorphology, a major controlling factor in the distribution of paleokarst reservoirs, was also analysed. The results show that one well can penetrate multiple cave layers of various sizes and that the caves are filled with multiple types of fill. The paleogeomorphology can be divided into highlands, slopes and depressions, which controlled the structure and fill characteristics of the paleokarst reservoirs. The results of this study can provide fundamental meter-scale datasets for interpreting detailed geologic features of deeply buried paleocaves, can be used to connect core- and seismic-scale interpretations, and can provide support for the recognition and development of these strongly heterogeneous reservoirs.

Combining Volcano Monitoring Timeseries Analyses with Bayesian Belief Networks to Update Hazard Forecast Estimates

NASA Astrophysics Data System (ADS)

Odbert, Henry; Hincks, Thea; Aspinall, Willy

2015-04-01

Volcanic hazard assessments must combine information about the physical processes of hazardous phenomena with observations that indicate the current state of a volcano. Incorporating both these lines of evidence can inform our belief about the likelihood (probability) and consequences (impact) of possible hazardous scenarios, forming a basis for formal quantitative hazard assessment. However, such evidence is often uncertain, indirect or incomplete. Approaches to volcano monitoring have advanced substantially in recent decades, increasing the variety and resolution of multi-parameter timeseries data recorded at volcanoes. Interpreting these multiple strands of parallel, partial evidence thus becomes increasingly complex. In practice, interpreting many timeseries requires an individual to be familiar with the idiosyncrasies of the volcano, monitoring techniques, configuration of recording instruments, observations from other datasets, and so on. In making such interpretations, an individual must consider how different volcanic processes may manifest as measureable observations, and then infer from the available data what can or cannot be deduced about those processes. We examine how parts of this process may be synthesised algorithmically using Bayesian inference. Bayesian Belief Networks (BBNs) use probability theory to treat and evaluate uncertainties in a rational and auditable scientific manner, but only to the extent warranted by the strength of the available evidence. The concept is a suitable framework for marshalling multiple strands of evidence (e.g. observations, model results and interpretations) and their associated uncertainties in a methodical manner. BBNs are usually implemented in graphical form and could be developed as a tool for near real-time, ongoing use in a volcano observatory, for example. We explore the application of BBNs in analysing volcanic data from the long-lived eruption at Soufriere Hills Volcano, Montserrat. We show how our method provides a route to formal propagation of uncertainties in hazard models. Such approaches provide an attractive route to developing an interface between volcano monitoring analyses and probabilistic hazard scenario analysis. We discuss the use of BBNs in hazard analysis as a tractable and traceable tool for fast, rational assimilation of complex, multi-parameter data sets in the context of timely volcanic crisis decision support.

1997 Savannah River Site annual epidemiologic surveillance report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a summary of epidemiologic surveillance data collected from Savannah River Site from January 1, 1997 through December 31, 1997. The data were collected by a coordinator at Savannah River Site and submitted to the Epidemiologic Surveillance Data Center located at Oak Ridge Institute for Science and Education, where quality control procedures and preliminary data analyses were carried out. The analyses were interpreted and the final report prepared by the DOE Office of Epidemiologic Studies. The information in this report provides highlights of the data analyses conducted on the 1997 data collected from Savannah River Site. The mainmore » sections of the report include: work force characteristics; absences due to injury or illness lasting 5 or more consecutive workdays; workplace illnesses, injuries, and deaths that were reportable to the Occupational Safety and Health Administration (''OSHA-recordable'' events); and disabilities and deaths among current workers. The 199 7 report includes a section on time trends that provides comparative information on the health of the work force from 1994 through 1997.« less

1996 Savannah River Site annual epidemiologic surveillance report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a summary of epidemiologic surveillance data collected from Savannah River Site from January 1, 1996 through December 31, 1996. The data were collected by a coordinator at Savannah River Site and submitted to the Epidemiologic Surveillance Data Center located at Oak Ridge Institute for Science and Education, where quality control procedures and preliminary data analyses were carried out. The analyses were interpreted and the final report prepared by the DOE Office of Epidemiologic Studies. The information in this report provides highlights of the data analyses conducted on the 1996 data collected from Savannah River Site. The mainmore » sections of the report include: work force characteristics; absences due to injury or illness lasting 5 or more consecutive workdays; workplace illnesses, injuries, and deaths that were reportable to the Occupational Safety and Health Administration (''OSHA-recordable'' events); and disabilities and deaths among current workers. The 1996 report includes a new section on time trends that provides comparative information on the health of the work force from 1994 through 1996.« less

Assessment of water quality parameters using multivariate analysis for Klang River basin, Malaysia.

PubMed

Mohamed, Ibrahim; Othman, Faridah; Ibrahim, Adriana I N; Alaa-Eldin, M E; Yunus, Rossita M

2015-01-01

This case study uses several univariate and multivariate statistical techniques to evaluate and interpret a water quality data set obtained from the Klang River basin located within the state of Selangor and the Federal Territory of Kuala Lumpur, Malaysia. The river drains an area of 1,288 km(2), from the steep mountain rainforests of the main Central Range along Peninsular Malaysia to the river mouth in Port Klang, into the Straits of Malacca. Water quality was monitored at 20 stations, nine of which are situated along the main river and 11 along six tributaries. Data was collected from 1997 to 2007 for seven parameters used to evaluate the status of the water quality, namely dissolved oxygen, biochemical oxygen demand, chemical oxygen demand, suspended solids, ammoniacal nitrogen, pH, and temperature. The data were first investigated using descriptive statistical tools, followed by two practical multivariate analyses that reduced the data dimensions for better interpretation. The analyses employed were factor analysis and principal component analysis, which explain 60 and 81.6% of the total variation in the data, respectively. We found that the resulting latent variables from the factor analysis are interpretable and beneficial for describing the water quality in the Klang River. This study presents the usefulness of several statistical methods in evaluating and interpreting water quality data for the purpose of monitoring the effectiveness of water resource management. The results should provide more straightforward data interpretation as well as valuable insight for managers to conceive optimum action plans for controlling pollution in river water.

The flow mechanism in the Chalk based on radio-isotope analyses of groundwater in the London Basin

USGS Publications Warehouse

Downing, R.A.; Pearson, F.J.; Smith, D.B.

1979-01-01

14C analyses of groundwaters from the Chalk of the London Basin are re-interpreted and the age of the groundwater is revised. Radio-isotope analyses are used to examine the flow mechanism in the aquifer. The evidence supports the view that a network of micro-fissures and larger intergranular pores in the matrix provides a significant part of the water pumped from Chalk wells and the major fissures distribute the water to the wells. Most of the matrix is fine-grained and contains a very old water. This diffuses into the micro-fissures and larger pores and is carried to the wells by the major fissures. ?? 1979.

Iterative categorization (IC): a systematic technique for analysing qualitative data

PubMed Central

2016-01-01

Abstract The processes of analysing qualitative data, particularly the stage between coding and publication, are often vague and/or poorly explained within addiction science and research more broadly. A simple but rigorous and transparent technique for analysing qualitative textual data, developed within the field of addiction, is described. The technique, iterative categorization (IC), is suitable for use with inductive and deductive codes and can support a range of common analytical approaches, e.g. thematic analysis, Framework, constant comparison, analytical induction, content analysis, conversational analysis, discourse analysis, interpretative phenomenological analysis and narrative analysis. Once the data have been coded, the only software required is a standard word processing package. Worked examples are provided. PMID:26806155

Satisfied Fools: Using J. S. Mill's Notion of Utility to Analyse the Impact of Vocationalism in Education within a Democratic Society

ERIC Educational Resources Information Center

Tarrant, Iona; Tarrant, James

2004-01-01

This paper proposes a new interpretation of John Stuart Mill's notion of utility, which is used to provide a utilitarian justification for an eclectic, rather than a vocational, education. Vocational education is strongly promoted in recent policy documents, which makes it important to raise the question of justification. Many existing…

The Two- and Three-Dimensional Models of the HK-WISC: A Confirmatory Factor Analysis.

ERIC Educational Resources Information Center

Chan, David W.; Lin, Wen-Ying

1996-01-01

Confirmatory analyses on the Hong Kong Wechsler Intelligence Scale for Children (HK-WISC) provided support for composite score interpretation based on the two- and three-dimensional models across age levels. Test sample was comprised of 1,100 children, ranging in age from 5 to 15 years at all 11 age levels specified by the HK-WISC. (KW)

Infrared Spectroscopic Imaging: The Next Generation

PubMed Central

Bhargava, Rohit

2013-01-01

Infrared (IR) spectroscopic imaging seemingly matured as a technology in the mid-2000s, with commercially successful instrumentation and reports in numerous applications. Recent developments, however, have transformed our understanding of the recorded data, provided capability for new instrumentation, and greatly enhanced the ability to extract more useful information in less time. These developments are summarized here in three broad areas— data recording, interpretation of recorded data, and information extraction—and their critical review is employed to project emerging trends. Overall, the convergence of selected components from hardware, theory, algorithms, and applications is one trend. Instead of similar, general-purpose instrumentation, another trend is likely to be diverse and application-targeted designs of instrumentation driven by emerging component technologies. The recent renaissance in both fundamental science and instrumentation will likely spur investigations at the confluence of conventional spectroscopic analyses and optical physics for improved data interpretation. While chemometrics has dominated data processing, a trend will likely lie in the development of signal processing algorithms to optimally extract spectral and spatial information prior to conventional chemometric analyses. Finally, the sum of these recent advances is likely to provide unprecedented capability in measurement and scientific insight, which will present new opportunities for the applied spectroscopist. PMID:23031693

related: an R package for analysing pairwise relatedness from codominant molecular markers.

PubMed

Pew, Jack; Muir, Paul H; Wang, Jinliang; Frasier, Timothy R

2015-05-01

Analyses of pairwise relatedness represent a key component to addressing many topics in biology. However, such analyses have been limited because most available programs provide a means to estimate relatedness based on only a single estimator, making comparison across estimators difficult. Second, all programs to date have been platform specific, working only on a specific operating system. This has the undesirable outcome of making choice of relatedness estimator limited by operating system preference, rather than being based on scientific rationale. Here, we present a new R package, called related, that can calculate relatedness based on seven estimators, can account for genotyping errors, missing data and inbreeding, and can estimate 95% confidence intervals. Moreover, simulation functions are provided that allow for easy comparison of the performance of different estimators and for analyses of how much resolution to expect from a given data set. Because this package works in R, it is platform independent. Combined, this functionality should allow for more appropriate analyses and interpretation of pairwise relatedness and will also allow for the integration of relatedness data into larger R workflows. © 2014 John Wiley & Sons Ltd.

Power, effects, confidence, and significance: an investigation of statistical practices in nursing research.

PubMed

Gaskin, Cadeyrn J; Happell, Brenda

2014-05-01

To (a) assess the statistical power of nursing research to detect small, medium, and large effect sizes; (b) estimate the experiment-wise Type I error rate in these studies; and (c) assess the extent to which (i) a priori power analyses, (ii) effect sizes (and interpretations thereof), and (iii) confidence intervals were reported. Statistical review. Papers published in the 2011 volumes of the 10 highest ranked nursing journals, based on their 5-year impact factors. Papers were assessed for statistical power, control of experiment-wise Type I error, reporting of a priori power analyses, reporting and interpretation of effect sizes, and reporting of confidence intervals. The analyses were based on 333 papers, from which 10,337 inferential statistics were identified. The median power to detect small, medium, and large effect sizes was .40 (interquartile range [IQR]=.24-.71), .98 (IQR=.85-1.00), and 1.00 (IQR=1.00-1.00), respectively. The median experiment-wise Type I error rate was .54 (IQR=.26-.80). A priori power analyses were reported in 28% of papers. Effect sizes were routinely reported for Spearman's rank correlations (100% of papers in which this test was used), Poisson regressions (100%), odds ratios (100%), Kendall's tau correlations (100%), Pearson's correlations (99%), logistic regressions (98%), structural equation modelling/confirmatory factor analyses/path analyses (97%), and linear regressions (83%), but were reported less often for two-proportion z tests (50%), analyses of variance/analyses of covariance/multivariate analyses of variance (18%), t tests (8%), Wilcoxon's tests (8%), Chi-squared tests (8%), and Fisher's exact tests (7%), and not reported for sign tests, Friedman's tests, McNemar's tests, multi-level models, and Kruskal-Wallis tests. Effect sizes were infrequently interpreted. Confidence intervals were reported in 28% of papers. The use, reporting, and interpretation of inferential statistics in nursing research need substantial improvement. Most importantly, researchers should abandon the misleading practice of interpreting the results from inferential tests based solely on whether they are statistically significant (or not) and, instead, focus on reporting and interpreting effect sizes, confidence intervals, and significance levels. Nursing researchers also need to conduct and report a priori power analyses, and to address the issue of Type I experiment-wise error inflation in their studies. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Structural validity of the Wechsler Intelligence Scale for Children-Fifth Edition: Confirmatory factor analyses with the 16 primary and secondary subtests.

PubMed

Canivez, Gary L; Watkins, Marley W; Dombrowski, Stefan C

2017-04-01

The factor structure of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V; Wechsler, 2014a) standardization sample (N = 2,200) was examined using confirmatory factor analyses (CFA) with maximum likelihood estimation for all reported models from the WISC-V Technical and Interpretation Manual (Wechsler, 2014b). Additionally, alternative bifactor models were examined and variance estimates and model-based reliability estimates (ω coefficients) were provided. Results from analyses of the 16 primary and secondary WISC-V subtests found that all higher-order CFA models with 5 group factors (VC, VS, FR, WM, and PS) produced model specification errors where the Fluid Reasoning factor produced negative variance and were thus judged inadequate. Of the 16 models tested, the bifactor model containing 4 group factors (VC, PR, WM, and PS) produced the best fit. Results from analyses of the 10 primary WISC-V subtests also found the bifactor model with 4 group factors (VC, PR, WM, and PS) produced the best fit. Variance estimates from both 16 and 10 subtest based bifactor models found dominance of general intelligence (g) in accounting for subtest variance (except for PS subtests) and large ω-hierarchical coefficients supporting general intelligence interpretation. The small portions of variance uniquely captured by the 4 group factors and low ω-hierarchical subscale coefficients likely render the group factors of questionable interpretive value independent of g (except perhaps for PS). Present CFA results confirm the EFA results reported by Canivez, Watkins, and Dombrowski (2015); Dombrowski, Canivez, Watkins, and Beaujean (2015); and Canivez, Dombrowski, and Watkins (2015). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Towards culturally competent paediatric oncology care. A qualitative study from the perspective of care providers.

PubMed

Suurmond, J; Lieveld, A; van de Wetering, M; Schouten-van Meeteren, A Y N

2017-11-01

In order to gain more insight on the influence of ethnic diversity in paediatric cancer care, the perspectives of care providers were explored. Semi-structured interviews were conducted among 12 paediatric oncologists and 13 nurses of two different paediatric oncology wards and were analysed using a framework method. We found that care providers described the contact with Turkish and Moroccan parents as more difficult. They offered two reasons for this: (1) language barriers between care provider and parents hindered the exchange of information; (2) cultural barriers between care provider and parents about sharing the diagnosis and palliative perspective hindered communication. Care providers reported different solutions to deal with these barriers, such as using an interpreter and improving their cultural knowledge about their patients. They, however, were not using interpreters sufficiently and were unaware of the importance of eliciting parents' perspectives. Communication techniques to overcome dilemmas between parents and care providers were not used and care providers were unaware of stereotypes and prejudice. Care providers should be offered insight in cultural barriers they are unaware of. Training in cultural competence might be a possibility to overcome manifest barriers. © 2017 John Wiley & Sons Ltd.

Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 2.1.

PubMed

Deutsch, Eric W; Overall, Christopher M; Van Eyk, Jennifer E; Baker, Mark S; Paik, Young-Ki; Weintraub, Susan T; Lane, Lydie; Martens, Lennart; Vandenbrouck, Yves; Kusebauch, Ulrike; Hancock, William S; Hermjakob, Henning; Aebersold, Ruedi; Moritz, Robert L; Omenn, Gilbert S

2016-11-04

Every data-rich community research effort requires a clear plan for ensuring the quality of the data interpretation and comparability of analyses. To address this need within the Human Proteome Project (HPP) of the Human Proteome Organization (HUPO), we have developed through broad consultation a set of mass spectrometry data interpretation guidelines that should be applied to all HPP data contributions. For submission of manuscripts reporting HPP protein identification results, the guidelines are presented as a one-page checklist containing 15 essential points followed by two pages of expanded description of each. Here we present an overview of the guidelines and provide an in-depth description of each of the 15 elements to facilitate understanding of the intentions and rationale behind the guidelines, for both authors and reviewers. Broadly, these guidelines provide specific directions regarding how HPP data are to be submitted to mass spectrometry data repositories, how error analysis should be presented, and how detection of novel proteins should be supported with additional confirmatory evidence. These guidelines, developed by the HPP community, are presented to the broader scientific community for further discussion.

Multispectral analysis of ocean dumped materials

NASA Technical Reports Server (NTRS)

Johnson, R. W.

1977-01-01

Experiments conducted in the Atlantic coastal zone indicated that plumes resulting from ocean dumping of acid wastes and sewage sludge have unique spectral characteristics. Remotely sensed wide area synoptic coverage provided information on these pollution features that was not readily available from other sources. Aircraft remotely sensed photographic and multispectral scanner data were interpreted by two methods. First, qualitative analyses in which pollution features were located, mapped, and identified without concurrent sea truth and, second, quantitative analyses in which concurrently collected sea truth was used to calibrate the remotely sensed data and to determine quantitative distributions of one or more parameters in a plume.

ASTROPHYSICAL SHRAPNEL: DISCRIMINATING AMONG NEAR-EARTH STELLAR EXPLOSION SOURCES OF LIVE RADIOACTIVE ISOTOPES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fry, Brian J.; Fields, Brian D.; Ellis, John R.

2015-02-10

We consider the production and deposition on Earth of isotopes with half-lives in the range 10{sup 5}-10{sup 8} yr that might provide signatures of nearby stellar explosions, extending previous analyses of Core-Collapse Supernovae (CCSNe) to include Electron-Capture Supernovae (ECSNe), Super-Asymptotic Giant Branch (SAGB) stars, Thermonuclear/Type Ia Supernovae (TNSNe), and Kilonovae/Neutron Star Mergers (KNe). We revisit previous estimates of the {sup 60}Fe and {sup 26}Al signatures, and extend these estimates to include {sup 244}Pu and {sup 53}Mn. We discuss interpretations of the {sup 60}Fe signals in terrestrial and lunar reservoirs in terms of a nearby stellar ejection ∼2.2 Myr ago, showingmore » that (1) the {sup 60}Fe yield rules out the TNSN and KN interpretations, (2) the {sup 60}Fe signals highly constrain SAGB interpretations but do not completely them rule out, (3) are consistent with a CCSN origin, and (4) are highly compatible with an ECSN interpretation. Future measurements could resolve the radioisotope deposition over time, and we use the Sedov blast wave solution to illustrate possible time-resolved profiles. Measuring such profiles would independently probe the blast properties including distance, and would provide additional constraints for the nature of the explosion.« less

Does time of day influence cancer detection and recall rates in mammography?

NASA Astrophysics Data System (ADS)

Stinton, Chris; Jenkinson, David; Adekanmbi, Victor; Clarke, Aileen; Taylor-Phillips, Sian

2017-03-01

Background: The interpretation of screening mammograms is influenced by factors such as reader experience and their annual interpretative volume. There is some evidence that time of day can also have an effect, with better diagnostic accuracy for readings conducted early in the day. This is not a consistent finding, however. The aim of our study is to provide further evidence on whether there is an effect of time of day on recall- and breast cancer detection rates. Method: We analysed breast screening data from 222,577 women from the Midlands of England. Data were split into three eight hour periods: 0900-1700, 1700-0100, 0100-0900. Differences in recall- and cancer detection rates were analysed using multilevel logistic regression models. Results: Recall rates were lowest for mammograms read between the 1700-0100 time period. Cancer detection rates were lowest during the 0100-0900 time period. Conclusions: Our findings suggest that there are fluctuations in recall- and cancer detection rates over the course of the day.

Investigation of the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV): exploratory and higher order factor analyses.

PubMed

Canivez, Gary L; Watkins, Marley W

2010-12-01

The present study examined the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical and Interpretation Manual (D. Wechsler, 2008b). Results indicated that the WAIS-IV subtests were properly associated with the theoretically proposed first-order factors, but all but one factor-extraction criterion recommended extraction of one or two factors. Hierarchical exploratory analyses with the Schmid and Leiman procedure found that the second-order g factor accounted for large portions of total and common variance, whereas the four first-order factors accounted for small portions of total and common variance. It was concluded that the WAIS-IV provides strong measurement of general intelligence, and clinical interpretation should be primarily at that level.

Interpretation of correlations in clinical research.

PubMed

Hung, Man; Bounsanga, Jerry; Voss, Maren Wright

2017-11-01

Critically analyzing research is a key skill in evidence-based practice and requires knowledge of research methods, results interpretation, and applications, all of which rely on a foundation based in statistics. Evidence-based practice makes high demands on trained medical professionals to interpret an ever-expanding array of research evidence. As clinical training emphasizes medical care rather than statistics, it is useful to review the basics of statistical methods and what they mean for interpreting clinical studies. We reviewed the basic concepts of correlational associations, violations of normality, unobserved variable bias, sample size, and alpha inflation. The foundations of causal inference were discussed and sound statistical analyses were examined. We discuss four ways in which correlational analysis is misused, including causal inference overreach, over-reliance on significance, alpha inflation, and sample size bias. Recent published studies in the medical field provide evidence of causal assertion overreach drawn from correlational findings. The findings present a primer on the assumptions and nature of correlational methods of analysis and urge clinicians to exercise appropriate caution as they critically analyze the evidence before them and evaluate evidence that supports practice. Critically analyzing new evidence requires statistical knowledge in addition to clinical knowledge. Studies can overstate relationships, expressing causal assertions when only correlational evidence is available. Failure to account for the effect of sample size in the analyses tends to overstate the importance of predictive variables. It is important not to overemphasize the statistical significance without consideration of effect size and whether differences could be considered clinically meaningful.

EVIDENCE FOR GRANULATION IN EARLY A-TYPE STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kallinger, Thomas; Matthews, Jaymie M.

2010-03-01

Stars with spectral types earlier than about F0 on (or close) to the main sequence have long been believed to lack observable surface convection, although evolutionary models of A-type stars do predict very thin surface convective zones. We present evidence for granulation in two {delta} Scuti stars of spectral type A2: HD 174936 and HD 50844. Recent analyses of space-based CoRoT data revealed up to some 1000 frequencies in the photometry of these stars. The frequencies were interpreted as individual pulsation modes. If true, there must be large numbers of nonradial modes of very high degree l which should suffermore » cancellation effects in disk-integrated photometry (even of high space-based precision). The p-mode interpretation of all the frequencies in HD 174936 and HD 50844 depends on the assumption of white (frequency-independent) noise. Our independent analyses of the data provide an alternative explanation: most of the peaks in the Fourier spectra are the signature of non-white granulation background noise, and less than about 100 of the frequencies are actual stellar p-modes in each star. We find granulation timescales which are consistent with scaling relations that describe cooler stars with known surface convection. If the granulation interpretation is correct, the hundreds of low-amplitude Fourier peaks reported in recent studies are falsely interpreted as independent pulsation modes and a significantly lower number of frequencies are associated with pulsation, consistent with only modes of low degree.« less

Interpreting problematic behavior: systematic compensatory adaptations as emergent phenomena in autism.

PubMed

Damico, Jack S; Nelson, Ryan L

2005-01-01

Based upon an emergent account of pragmatic ability and disability, this article provides theoretical and empirical support for a conceptually deeper understanding of some systematic behaviors that have served as diagnostic indices in communicatively impaired populations. Specifically, by employing conversation analysis, several examples of problematic behaviors in autism are analysed as a specific type of compensatory adaptation. Theoretical and clinical implications are discussed.

The incredible journey of mankind: Helicobacter pylori as the narrator.

PubMed

Desikan, P

2010-01-01

Over the past decade, sequence differences between microbes from various geographical areas have been studied with the intent to interpret population movements of their hosts. An organism that is a reliable storehouse of such data, by virtue of its long association with its human host, is Helicobacter pylori. Functional and comparative analyses of its genome provide fascinating insights into human behaviour in the ancient past.

Guide to the Job Training Partnership Act. Cumulative Analyses of the Law and Subsequent Policy Issuances. Installment #1.

ERIC Educational Resources Information Center

National Alliance of Business, Inc., Washington, DC.

This guide is the first in a series of interpretive explanations of the Job Training Partnership Act (JTPA). It is designed to provide practitioners and business leaders involved in state and local employment and training programs with an understanding of how to implement the public-private partnership of JTPA. This first edition does the…

Grain-Scale Analyses of Curiosity Data at Marias Pass, Gale Crater, Mars: Methods Comparison and Depositional Interpretation

NASA Astrophysics Data System (ADS)

Sacks, L. E.; Edgar, L. A.; Edwards, C. S.; Anderson, R. B.

2016-12-01

Images acquired by the Mars Hand Lens Imager (MAHLI) and the ChemCam Remote Micro Imager (RMI) onboard the Mars Science Laboratory (MSL) Curiosity rover provide grain-scale data that are critical for interpreting sedimentary deposits. At the location informally known as Marias Pass, Curiosity used both cameras to image the nine rock targets used in this study. We used manual point-counts to measure grain size distributions from those images to compare the abilities of the two cameras. The manually derived results were compared to automated grain size data obtained using pyDGS (Digital Grain Size), an open-source python program. Grain size analyses were used to test the lacustrine and aeolian depositional hypotheses for the Murray and Stimson formations at Marias Pass. Results indicate that the MAHLI and RMI instruments, despite their different fields of view and properties, provide comparable grain size measurements. Additionally, pyDGS does not account for grains smaller than a few pixels and thus does not report representative grain size data and should not be used on images with a large fraction of unresolved grains. Finally, the data collected at Marias Pass are consistent with the existing interpretations of the Murray and Stimson formations. The fine-grained results of the Murray formation analyses support lacustrine deposition, while the mean grain size of the Stimson formation is fine to medium sized sand, consistent with aeolian deposition. However, directly above the contact with the Murray formation, larger rip-up clasts of the Murray formation are present in the Stimson formation. It is possible that water was involved at this stage of erosion and re-deposition, prior to aeolian deposition. Additionally, the grain-scale analyses conducted in this study show that the Dust Removal Tool on Curiosity should be used prior to capturing images for grain-scale analysis. Two images of the target informally named Ronan, taken before and after brushing, resulted in dramatically different grain size results, suggesting that the common, thin layer of dust obscured the true grain size distribution. These grain-scale analyses at Marias Pass have important implications for the collection and processing of image data, as well as the depositional environments recorded in Gale crater. Funded by NSF Grant AST-1461200

Space shuttle orbiter digital data processing system timing sensitivity analysis OFT ascent phase

NASA Technical Reports Server (NTRS)

Lagas, J. J.; Peterka, J. J.; Becker, D. A.

1977-01-01

Dynamic loads were investigated to provide simulation and analysis of the space shuttle orbiter digital data processing system (DDPS). Segments of the ascent test (OFT) configuration were modeled utilizing the information management system interpretive model (IMSIM) in a computerized simulation modeling of the OFT hardware and software workload. System requirements for simulation of the OFT configuration were defined, and sensitivity analyses determined areas of potential data flow problems in DDPS operation. Based on the defined system requirements and these sensitivity analyses, a test design was developed for adapting, parameterizing, and executing IMSIM, using varying load and stress conditions for model execution. Analyses of the computer simulation runs are documented, including results, conclusions, and recommendations for DDPS improvements.

God image and happiness in chronic pain patients: the mediating role of disease interpretation.

PubMed

Dezutter, Jessie; Luyckx, Koen; Schaap-Jonker, Hanneke; Büssing, Arndt; Corveleyn, Jozef; Hutsebaut, Dirk

2010-05-01

The present study explored the role of the emotional experience of God (i.e., positive and negative God images) in the happiness of chronic pain (CP) patients. Framed in the transactional model of stress, we tested a model in which God images would influence happiness partially through its influence on disease interpretation as a mediating mechanism. We expected God images to have both a direct and an indirect (through the interpretation of disease) effect on happiness. A cross-sectional questionnaire design was adopted in order to measure demographics, pain condition, God images, disease interpretation, and happiness. One hundred thirty-six CP patients, all members of a national patients' association, completed the questionnaires. Correlational analyses showed meaningful associations among God images, disease interpretation, and happiness. Path analyses from a structural equation modeling approach indicated that positive God images seemed to influence happiness, both directly and indirectly through the pathway of positive interpretation of the disease. Ancillary analyses showed that the negative influence of angry God images on happiness disappeared after controlling for pain severity. The results indicated that one's emotional experience of God has an influence on happiness in CP patients, both directly and indirectly through the pathway of positive disease interpretation. These findings can be framed within the transactional theory of stress and can stimulate further pain research investigating the possible effects of religion in the adaptation to CP.

XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.

PubMed

Fang, Hai; Knezevic, Bogdan; Burnham, Katie L; Knight, Julian C

2016-12-13

Biological interpretation of genomic summary data such as those resulting from genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) studies is one of the major bottlenecks in medical genomics research, calling for efficient and integrative tools to resolve this problem. We introduce eXploring Genomic Relations (XGR), an open source tool designed for enhanced interpretation of genomic summary data enabling downstream knowledge discovery. Targeting users of varying computational skills, XGR utilises prior biological knowledge and relationships in a highly integrated but easily accessible way to make user-input genomic summary datasets more interpretable. We show how by incorporating ontology, annotation, and systems biology network-driven approaches, XGR generates more informative results than conventional analyses. We apply XGR to GWAS and eQTL summary data to explore the genomic landscape of the activated innate immune response and common immunological diseases. We provide genomic evidence for a disease taxonomy supporting the concept of a disease spectrum from autoimmune to autoinflammatory disorders. We also show how XGR can define SNP-modulated gene networks and pathways that are shared and distinct between diseases, how it achieves functional, phenotypic and epigenomic annotations of genes and variants, and how it enables exploring annotation-based relationships between genetic variants. XGR provides a single integrated solution to enhance interpretation of genomic summary data for downstream biological discovery. XGR is released as both an R package and a web-app, freely available at http://galahad.well.ox.ac.uk/XGR .

Ecological Momentary Assessments and Automated Time Series Analysis to Promote Tailored Health Care: A Proof-of-Principle Study.

PubMed

van der Krieke, Lian; Emerencia, Ando C; Bos, Elisabeth H; Rosmalen, Judith Gm; Riese, Harriëtte; Aiello, Marco; Sytema, Sjoerd; de Jonge, Peter

2015-08-07

Health promotion can be tailored by combining ecological momentary assessments (EMA) with time series analysis. This combined method allows for studying the temporal order of dynamic relationships among variables, which may provide concrete indications for intervention. However, application of this method in health care practice is hampered because analyses are conducted manually and advanced statistical expertise is required. This study aims to show how this limitation can be overcome by introducing automated vector autoregressive modeling (VAR) of EMA data and to evaluate its feasibility through comparisons with results of previously published manual analyses. We developed a Web-based open source application, called AutoVAR, which automates time series analyses of EMA data and provides output that is intended to be interpretable by nonexperts. The statistical technique we used was VAR. AutoVAR tests and evaluates all possible VAR models within a given combinatorial search space and summarizes their results, thereby replacing the researcher's tasks of conducting the analysis, making an informed selection of models, and choosing the best model. We compared the output of AutoVAR to the output of a previously published manual analysis (n=4). An illustrative example consisting of 4 analyses was provided. Compared to the manual output, the AutoVAR output presents similar model characteristics and statistical results in terms of the Akaike information criterion, the Bayesian information criterion, and the test statistic of the Granger causality test. Results suggest that automated analysis and interpretation of times series is feasible. Compared to a manual procedure, the automated procedure is more robust and can save days of time. These findings may pave the way for using time series analysis for health promotion on a larger scale. AutoVAR was evaluated using the results of a previously conducted manual analysis. Analysis of additional datasets is needed in order to validate and refine the application for general use.

Ecological Momentary Assessments and Automated Time Series Analysis to Promote Tailored Health Care: A Proof-of-Principle Study

PubMed Central

Emerencia, Ando C; Bos, Elisabeth H; Rosmalen, Judith GM; Riese, Harriëtte; Aiello, Marco; Sytema, Sjoerd; de Jonge, Peter

2015-01-01

Background Health promotion can be tailored by combining ecological momentary assessments (EMA) with time series analysis. This combined method allows for studying the temporal order of dynamic relationships among variables, which may provide concrete indications for intervention. However, application of this method in health care practice is hampered because analyses are conducted manually and advanced statistical expertise is required. Objective This study aims to show how this limitation can be overcome by introducing automated vector autoregressive modeling (VAR) of EMA data and to evaluate its feasibility through comparisons with results of previously published manual analyses. Methods We developed a Web-based open source application, called AutoVAR, which automates time series analyses of EMA data and provides output that is intended to be interpretable by nonexperts. The statistical technique we used was VAR. AutoVAR tests and evaluates all possible VAR models within a given combinatorial search space and summarizes their results, thereby replacing the researcher’s tasks of conducting the analysis, making an informed selection of models, and choosing the best model. We compared the output of AutoVAR to the output of a previously published manual analysis (n=4). Results An illustrative example consisting of 4 analyses was provided. Compared to the manual output, the AutoVAR output presents similar model characteristics and statistical results in terms of the Akaike information criterion, the Bayesian information criterion, and the test statistic of the Granger causality test. Conclusions Results suggest that automated analysis and interpretation of times series is feasible. Compared to a manual procedure, the automated procedure is more robust and can save days of time. These findings may pave the way for using time series analysis for health promotion on a larger scale. AutoVAR was evaluated using the results of a previously conducted manual analysis. Analysis of additional datasets is needed in order to validate and refine the application for general use. PMID:26254160

Methylation analysis of polysaccharides: Technical advice.

PubMed

Sims, Ian M; Carnachan, Susan M; Bell, Tracey J; Hinkley, Simon F R

2018-05-15

Glycosyl linkage (methylation) analysis is used widely for the structural determination of oligo- and poly-saccharides. The procedure involves derivatisation of the individual component sugars of a polysaccharide to partially methylated alditol acetates which are analysed and quantified by gas chromatography-mass spectrometry. The linkage positions for each component sugar can be determined by correctly identifying the partially methylated alditol acetates. Although the methods are well established, there are many technical aspects to this procedure and both careful attention to detail and considerable experience are required to achieve a successful methylation analysis and to correctly interpret the data generated. The aim of this article is to provide the technical details and critical procedural steps necessary for a successful methylation analysis and to assist researchers (a) with interpreting data correctly and (b) in providing the comprehensive data required for reviewers to fully assess the work. Copyright © 2018 Elsevier Ltd. All rights reserved.

Seeking support: An interpretative phenomenological analysis of an Internet message board for people with Complex Regional Pain Syndrome.

PubMed

Rodham, Karen; McCabe, Candy; Blake, David

2009-07-01

In this article, we report on the findings of a qualitative inquiry into how an online message board for people who have Complex Regional Pain Syndrome (CRPS) was used by its members. All messages (and responses) posted on the CRPS message board over a 4-month period were collected retrospectively. The data were analysed using the method of Interpretative Phenomenological Analysis. Members used the message board to seek (and provide) support to those with CRPS, and also to express their emotions, feelings and experiences linked to their condition. The message board provided an important source of support for a patient group that can otherwise become isolated as a result of their mobility problems. Furthermore, the analysis revealed the unrealistic hopes that patients can hold concerning the anticipated outcomes of their treatment. This is an important issue for healthcare professionals to explicitly address when interacting with the patient group.

Cued Speech Transliteration: Effects of Speaking Rate and Lag Time on Production Accuracy

PubMed Central

Tessler, Morgan P.

2016-01-01

Many deaf and hard-of-hearing children rely on interpreters to access classroom communication. Although the exact level of access provided by interpreters in these settings is unknown, it is likely to depend heavily on interpreter accuracy (portion of message correctly produced by the interpreter) and the factors that govern interpreter accuracy. In this study, the accuracy of 12 Cued Speech (CS) transliterators with varying degrees of experience was examined at three different speaking rates (slow, normal, fast). Accuracy was measured with a high-resolution, objective metric in order to facilitate quantitative analyses of the effect of each factor on accuracy. Results showed that speaking rate had a large negative effect on accuracy, caused primarily by an increase in omitted cues, whereas the effect of lag time on accuracy, also negative, was quite small and explained just 3% of the variance. Increased experience level was generally associated with increased accuracy; however, high levels of experience did not guarantee high levels of accuracy. Finally, the overall accuracy of the 12 transliterators, 54% on average across all three factors, was low enough to raise serious concerns about the quality of CS transliteration services that (at least some) children receive in educational settings. PMID:27221370

Eureka-DMA: an easy-to-operate graphical user interface for fast comprehensive investigation and analysis of DNA microarray data.

PubMed

Abelson, Sagi

2014-02-24

In the past decade, the field of molecular biology has become increasingly quantitative; rapid development of new technologies enables researchers to investigate and address fundamental issues quickly and in an efficient manner which were once impossible. Among these technologies, DNA microarray provides methodology for many applications such as gene discovery, diseases diagnosis, drug development and toxicological research and it has been used increasingly since it first emerged. Multiple tools have been developed to interpret the high-throughput data produced by microarrays. However, many times, less consideration has been given to the fact that an extensive and effective interpretation requires close interplay between the bioinformaticians who analyze the data and the biologists who generate it. To bridge this gap and to simplify the usability of such tools we developed Eureka-DMA - an easy-to-operate graphical user interface that allows bioinformaticians and bench-biologists alike to initiate analyses as well as to investigate the data produced by DNA microarrays. In this paper, we describe Eureka-DMA, a user-friendly software that comprises a set of methods for the interpretation of gene expression arrays. Eureka-DMA includes methods for the identification of genes with differential expression between conditions; it searches for enriched pathways and gene ontology terms and combines them with other relevant features. It thus enables the full understanding of the data for following testing as well as generating new hypotheses. Here we show two analyses, demonstrating examples of how Eureka-DMA can be used and its capability to produce relevant and reliable results. We have integrated several elementary expression analysis tools to provide a unified interface for their implementation. Eureka-DMA's simple graphical user interface provides effective and efficient framework in which the investigator has the full set of tools for the visualization and interpretation of the data with the option of exporting the analysis results for later use in other platforms. Eureka-DMA is freely available for academic users and can be downloaded at http://blue-meduza.org/Eureka-DMA.

Is the statistic value all we should care about in neuroimaging?

PubMed

Chen, Gang; Taylor, Paul A; Cox, Robert W

2017-02-15

Here we address an important issue that has been embedded within the neuroimaging community for a long time: the absence of effect estimates in results reporting in the literature. The statistic value itself, as a dimensionless measure, does not provide information on the biophysical interpretation of a study, and it certainly does not represent the whole picture of a study. Unfortunately, in contrast to standard practice in most scientific fields, effect (or amplitude) estimates are usually not provided in most results reporting in the current neuroimaging publications and presentations. Possible reasons underlying this general trend include (1) lack of general awareness, (2) software limitations, (3) inaccurate estimation of the BOLD response, and (4) poor modeling due to our relatively limited understanding of FMRI signal components. However, as we discuss here, such reporting damages the reliability and interpretability of the scientific findings themselves, and there is in fact no overwhelming reason for such a practice to persist. In order to promote meaningful interpretation, cross validation, reproducibility, meta and power analyses in neuroimaging, we strongly suggest that, as part of good scientific practice, effect estimates should be reported together with their corresponding statistic values. We provide several easily adaptable recommendations for facilitating this process. Published by Elsevier Inc.

A bridge between cultures: interpreters' perspectives of consultations with migrant oncology patients.

PubMed

Butow, Phyllis N; Lobb, Elizabeth; Jefford, Michael; Goldstein, David; Eisenbruch, Maurice; Girgis, Afaf; King, Madeleine; Sze, Ming; Aldridge, Lynley; Schofield, Penelope

2012-02-01

Migration is increasing worldwide. In previous research into people with cancer from culturally and linguistically diverse backgrounds, interpreter accuracy, professionalism and continuity have emerged as key concerns for patients. Little is known about interpreters' perceptions of their role and the challenges they face. This study aimed to obtain their perspective. Thirty interpreters (Greek n = 7, Chinese n = 11, and Arabic n = 12) participated in four focus groups which were audio-taped, transcribed and analysed for themes using N-Vivo software. Skills as an interpreter were broadly perceived as conveying information accurately, being confidential and impartial. Three broad dilemmas faced by interpreters emerged: accuracy versus understanding; translating only versus cultural advocacy and sensitivity; and professionalism versus providing support. Some saw themselves as merely an accurate conduit of information, while others saw their role in broader terms, encompassing patient advocacy, cultural brokerage and provision of emotional support. Perceived challenges in their role included lack of continuity, managing their own emotions especially after bad news consultations, and managing diverse patient and family expectations. Training and support needs included medical terminology, communication and counselling skills and debriefing. Interpreters suggested that oncologists check on interpreter/patient's language or dialect compatibility; use lay language and short sentences; and speak in the first person. Resolving potential conflicts between information provision and advocacy is an important area of cross-cultural communication research. Further training and support is required to enhance interpreters' competence in managing delicate situations from a professional, cultural and psychological perspective; and to assist doctors to collaborate with interpreters to ensure culturally competent communication. Ultimately, this will improve interpreters' well-being and patient care.

Evolution, Discovery, and Interpretations of Arthropod Mushroom Bodies

PubMed Central

Strausfeld, Nicholas J.; Hansen, Lars; Li, Yongsheng; Gomez, Robert S.; Ito, Kei

1998-01-01

Mushroom bodies are prominent neuropils found in annelids and in all arthropod groups except crustaceans. First explicitly identified in 1850, the mushroom bodies differ in size and complexity between taxa, as well as between different castes of a single species of social insect. These differences led some early biologists to suggest that the mushroom bodies endow an arthropod with intelligence or the ability to execute voluntary actions, as opposed to innate behaviors. Recent physiological studies and mutant analyses have led to divergent interpretations. One interpretation is that the mushroom bodies conditionally relay to higher protocerebral centers information about sensory stimuli and the context in which they occur. Another interpretation is that they play a central role in learning and memory. Anatomical studies suggest that arthropod mushroom bodies are predominately associated with olfactory pathways except in phylogenetically basal insects. The prominent olfactory input to the mushroom body calyces in more recent insect orders is an acquired character. An overview of the history of research on the mushroom bodies, as well as comparative and evolutionary considerations, provides a conceptual framework for discussing the roles of these neuropils. PMID:10454370

Deep Space Mission Trend Analyses: A Briefing to the Next Generation EBRE Study Team

NASA Technical Reports Server (NTRS)

Abraham, Douglas S.

2012-01-01

Determination of stakeholder needs for next generation implementations necessitates a multi ]pronged approach. . Future mission set analyses provide a lower gbound h for some of these needs. . Earth ]based analogies provide an upper gbound h for some of these needs. . Interpreting the results requires being mindful of both the near ]term contextual factors and long ]term factors that are in play. . In the context of last year fs analyses, the current budget environment, the potential Pu ]238 shortage, and SMD fs gsingle 34m only h policy may, collectively, create a future deep space mission set that, from a capacity and end ]to ]end link difficulty standpoint, is no more challenging than it is today. . Nonetheless, data rates and volumes continue to increase, suggesting capability and spectrum challenges ahead. These results agree with the results from the Earthbased analogies. . Emerging developments such as smallsats and distributed spacecraft could significantly change the capacity and end ]to ]end link difficulty picture.

A multilocus perspective on the speciation history of a North American aridland toad (Anaxyrus punctatus).

PubMed

Bryson, Robert W; Jaeger, Jef R; Lemos-Espinal, Julio A; Lazcano, David

2012-09-01

Interpretations of phylogeographic patterns can change when analyses shift from single gene-tree to multilocus coalescent analyses. Using multilocus coalescent approaches, a species tree and divergence times can be estimated from a set of gene trees while accounting for gene-tree stochasticity. We utilized the conceptual strengths of a multilocus coalescent approach coupled with complete range-wide sampling to examine the speciation history of a broadly distributed, North American warm-desert toad, Anaxyrus punctatus. Phylogenetic analyses provided strong support for three major lineages within A. punctatus. Each lineage broadly corresponded to one of three desert regions. Early speciation in A. punctatus appeared linked to late Miocene-Pliocene development of the Baja California peninsula. This event was likely followed by a Pleistocene divergence associated with the separation of the Chihuahuan and Sonoran Deserts. Our multilocus coalescent-based reconstruction provides an informative contrast to previous single gene-tree estimates of the evolutionary history of A. punctatus. Copyright © 2012 Elsevier Inc. All rights reserved.

Geological Interpretation of Bathymetric and Backscatter Imagery of the Sea Floor off Eastern Cape Cod, Massachusetts

USGS Publications Warehouse

Poppe, Larry J.; Paskevich, Valerie F.; Butman, Bradford; Ackerman, Seth D.; Danforth, William W.; Foster, Dave S.; Blackwood, Dann S.

2006-01-01

The imagery, interpretive data layers, and data presented herein were derived from multibeam echo-sounder data collected off Eastern Cape Cod, Massachusetts, and from the stations occupied to verify these acoustic data. The basic data layers show sea-floor topography, sun-illuminated shaded relief, and backscatter intensity; interpretive layers show the distributions of surficial sediment and sedimentary environments. Presented verification data include new and historical sediment grain-size analyses and a gallery of still photographs of the seabed. The multibeam data, which cover a narrow band of the sea floor extending from Provincetown around the northern tip of Cape Cod and south southeastward to off Monomoy Island, were collected during transits between concurrent mapping projects in the Stellwagen Bank National Marine Sanctuary (Valentine and others, 2001; Butman and others, 2004; and Valentine, 2005) and Great South Channel (Valentine and others, 2003a, b, c, d). Although originally collected to maximize the use of time aboard ship, these data provide a fundamental framework for research and management activities in this part of the Gulf of Maine (Noji and others, 2004), show the composition and terrain of the seabed, and provide information on sediment transport and benthic habitat. These data and interpretations also support ongoing modeling studies of the lower Cape's aquifer system (Masterson, 2004) and of erosional hotspots along the Cape Cod National Seashore (List and others, 2006).

Shallow Refraction and Rg Analysis at the Source Physics Experiment Site

NASA Astrophysics Data System (ADS)

Rowe, C. A.; Carmichael, J. D.; Patton, H. J.; Snelson, C. M.; Coblentz, D. D.; Larmat, C. S.; Yang, X.

2014-12-01

We present analyses of the two-dimensional (2D) seismic structure beneath Source Physics Experiments (SPE) geophone lines that extended 100 to 2000 m from the source borehole with 100 m spacing. With seismic sources provided only at one end of the geophone lines, standard refraction profiling methods are unable to resolve the seismic velocity structures unambiguously. In previous work we have shown overall agreement between body-wave refraction modeling and Rg dispersion curves for the least complex of the five lines, Line 2, leading us to offer a simplified1D model for this line. A more detailed inspection of Line 2 supports a 2D re-interpretation of the structure on this line. We observe variation along the length of the line, as evidenced by abrupt and consistent changes in the behavior of surface waves at higher frequencies. We interpret this as a manifestation of significant material or structural heterogeneity in the shallowest strata. This interpretation is consistent with P-wave and Rg attenuation observations. Planned additional sources, both at the distal ends of the profiles and intermittently within their lengths, will provide significant enhancement to our ability to resolve this complicated shallow structure.

Arabic-speaking migrants' experiences of the use of interpreters in healthcare: a qualitative explorative study.

PubMed

Hadziabdic, Emina; Hjelm, Katarina

2014-06-16

Arabic-speaking migrants have constituted a growing population in recent years. This entails major challenges to ensure good communication in the healthcare encounter in order to provide individual and holistic healthcare. One of the solutions to ensure good communication between patient and healthcare staff who do not share the same language is to use a professional interpreter. To our knowledge, no previous qualitative studies have been found concerning Arabic-speaking migrants and the use of interpreters. This study aims to ascertain their individual experiences which can help extend our understanding of the studied area. A purposive sample of 13 Arabic-speaking persons with experience of using interpreters in healthcare encounters. Data were collected between November 2012 and March 2013 by four focus-group interviews and analysed with qualitative analysis according to a method described for focus groups. Four categories appeared from the analysis: 1) The professional interpreter as spokesperson; 2) Different types of interpreters and modes of interpretation adapting to the healthcare encounter; 3) The professional interpreter's task and personal properties affected the use of professional interpreters in a healthcare encounter; 4) Future planning of the use of professional interpreters in a healthcare encounter. The main findings were that the use of interpreters was experienced both as a possibility and as a problem. The preferred type of interpreters depended on the interpreter's dialect and ability to interpret correctly. Besides the professional interpreter's qualities of good skill in language and medical terminology, translation ability, neutrality and objectivity, Arabic-speaking participants stated that professional interpreters need to share the same origin, religion, dialect, gender and political views as the patient in order to facilitate the interpreter use and avoid inappropriate treatment. The study showed that the personal qualities of a good interpreter not only cover language ability but also origin, religion, dialect, gender and political views. Thus, there is need to develop strategies for personalized healthcare in order to avoid inappropriate communication, to satisfy the preferences of the person in need of interpreters and improve the impact of interpretation on the quality of healthcare.

Iterative categorization (IC): a systematic technique for analysing qualitative data.

PubMed

Neale, Joanne

2016-06-01

The processes of analysing qualitative data, particularly the stage between coding and publication, are often vague and/or poorly explained within addiction science and research more broadly. A simple but rigorous and transparent technique for analysing qualitative textual data, developed within the field of addiction, is described. The technique, iterative categorization (IC), is suitable for use with inductive and deductive codes and can support a range of common analytical approaches, e.g. thematic analysis, Framework, constant comparison, analytical induction, content analysis, conversational analysis, discourse analysis, interpretative phenomenological analysis and narrative analysis. Once the data have been coded, the only software required is a standard word processing package. Worked examples are provided. © 2016 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

Internal validation of STRmix™ for the interpretation of single source and mixed DNA profiles.

PubMed

Moretti, Tamyra R; Just, Rebecca S; Kehl, Susannah C; Willis, Leah E; Buckleton, John S; Bright, Jo-Anne; Taylor, Duncan A; Onorato, Anthony J

2017-07-01

The interpretation of DNA evidence can entail analysis of challenging STR typing results. Genotypes inferred from low quality or quantity specimens, or mixed DNA samples originating from multiple contributors, can result in weak or inconclusive match probabilities when a binary interpretation method and necessary thresholds (such as a stochastic threshold) are employed. Probabilistic genotyping approaches, such as fully continuous methods that incorporate empirically determined biological parameter models, enable usage of more of the profile information and reduce subjectivity in interpretation. As a result, software-based probabilistic analyses tend to produce more consistent and more informative results regarding potential contributors to DNA evidence. Studies to assess and internally validate the probabilistic genotyping software STRmix™ for casework usage at the Federal Bureau of Investigation Laboratory were conducted using lab-specific parameters and more than 300 single-source and mixed contributor profiles. Simulated forensic specimens, including constructed mixtures that included DNA from two to five donors across a broad range of template amounts and contributor proportions, were used to examine the sensitivity and specificity of the system via more than 60,000 tests comparing hundreds of known contributors and non-contributors to the specimens. Conditioned analyses, concurrent interpretation of amplification replicates, and application of an incorrect contributor number were also performed to further investigate software performance and probe the limitations of the system. In addition, the results from manual and probabilistic interpretation of both prepared and evidentiary mixtures were compared. The findings support that STRmix™ is sufficiently robust for implementation in forensic laboratories, offering numerous advantages over historical methods of DNA profile analysis and greater statistical power for the estimation of evidentiary weight, and can be used reliably in human identification testing. With few exceptions, likelihood ratio results reflected intuitively correct estimates of the weight of the genotype possibilities and known contributor genotypes. This comprehensive evaluation provides a model in accordance with SWGDAM recommendations for internal validation of a probabilistic genotyping system for DNA evidence interpretation. Copyright © 2017. Published by Elsevier B.V.

A tutorial solution to scattering of radiation in a thin atmosphere bounded below by a diffusely reflecting, absorbing surface

NASA Technical Reports Server (NTRS)

Buglia, J. J.

1982-01-01

A simple tutorial method, based on a photon tracking procedure, is described to determine the spherical albedo for a thin atmosphere overlying a reflecting surface. This procedure is used to provide a physical structure with which to interpret the more detailed but highly mathematical analyses presented. The final equations are shown to be in good numerical agreement with more exact solutions for thin atmospheres.

Genome-Scale Metabolic Reconstructions and Theoretical Investigation of Methane Conversion in Methylomicrobium buryatense Strain 5G(B1)

DOE PAGES

de la Torre, Andrea; Metivier, Aisha; Chu, Frances; ...

2015-11-25

Methane-utilizing bacteria (methanotrophs) are capable of growth on methane and are attractive systems for bio-catalysis. However, the application of natural methanotrophic strains to large-scale production of value-added chemicals/biofuels requires a number of physiological and genetic alterations. An accurate metabolic model coupled with flux balance analysis can provide a solid interpretative framework for experimental data analyses and integration.

The use of Spanish by medical students and residents at one university hospital.

PubMed

Yawman, Daniel; McIntosh, Scott; Fernandez, Diana; Auinger, Peggy; Allan, Marjorie; Weitzman, Michael

2006-05-01

To describe how medical trainees report communication with Spanish-speaking patients, and to assess trainees' desire to improve their language skills and have those skills formally evaluated. A questionnaire was mailed to all fourth-year medical students and non-first-year residents in family practice, pediatrics, medicine, medicine-pediatrics, emergency medicine, and obstetrics-gynecology at the University of Rochester School of Medicine and Dentistry in 2004 (N = 263). The response rate was 92% (241/263). Each respondent had at least one year of clinical experience at the hospital. Of the 83% (199/241) who reported less than conversational Spanish language skills, 53% had taken a history and/or provided medical advice directly to Spanish-speaking patients without any form of interpretation. When an interpreter was used, professional interpretation services were used less frequently than other forms of interpretation (42% versus 58%, p < .05). Analyses were performed on the 68% (164/241) who reported having at least rudimentary Spanish skills: 85% reported that they would probably or definitely participate in further individual language training, 70% expressed at least possible willingness to have their Spanish formally evaluated, and 80% predicted that it is at least possible that they will use their Spanish as attending physicians. At the time of this study, this hospital's medical students and residents from multiple specialties used inadequate Spanish language skills to provide direct medical care despite the availability of professional interpretation services. Most of these trainees were motivated to improve their Spanish and would welcome evaluation of their language skills.

Integrated Network Analyses for Functional Genomic Studies in Cancer

PubMed Central

Wilson, Jennifer L.; Hemann, Michael T.; Fraenkel, Ernest; Lauffenburger, Douglas A.

2013-01-01

RNA-interference (RNAi) studies hold great promise for functional investigation of the significance of genetic variations and mutations, as well as potential synthetic lethalities, for understanding and treatment of cancer, yet technical and conceptual issues currently diminish the potential power of this approach. While numerous research groups are usefully employing this kind of functional genomic methodology to identify molecular mediators of disease severity, response, and resistance to treatment, findings are generally confounded by “off-target” effects. These effects arise from a variety of issues beyond non-specific reagent behavior, such as biological cross-talk and feedback processes so thus can occur even with specific perturbation. Interpreting RNAi results in a network framework instead of merely as individual “hits” or “targets” leverages contributions from all hit/target contributions to pathways via their relationships with other network nodes. This interpretation can ameliorate dependence on individual reagent performance and increase confidence in biological validation. Here we provide background on RNAi studies in cancer applications, review key challenges with functional genomics, and motivate the use of network models grounded in pathway analyses. PMID:23811269

A biased review of biases in Twitter studies on political collective action

NASA Astrophysics Data System (ADS)

Cihon, Peter; Yasseri, Taha

2016-08-01

In recent years researchers have gravitated to Twitter and other social media platforms as fertile ground for empirical analysis of social phenomena. Social media provides researchers access to trace data of interactions and discourse that once went unrecorded in the offline world. Researchers have sought to use these data to explain social phenomena both particular to social media and applicable to the broader social world. This paper offers a minireview of Twitter-based research on political crowd behaviour. This literature offers insight into particular social phenomena on Twitter, but often fails to use standardized methods that permit interpretation beyond individual studies. Moreover, the literature fails to ground methodologies and results in social or political theory, divorcing empirical research from the theory needed to interpret it. Rather, investigations focus primarily on methodological innovations for social media analyses, but these too often fail to sufficiently demonstrate the validity of such methodologies. This minireview considers a small number of selected papers; we analyse their (often lack of) theoretical approaches, review their methodological innovations, and offer suggestions as to the relevance of their results for political scientists and sociologists.

Interpreting large-scale experiments on effects of trawling on benthic fauna: an empirical test of the potential effects of spatial confounding in experiments without replicated control and trawled areas.

PubMed

Lindegarth; Valentinsson; Hansson; Ulmestrand

2000-03-15

Disturbances due to trawling and dredging is a serious threat to assemblages of benthic marine animals. We tested hypotheses about effects of trawling on benthic assemblages in a manipulative field experiment, using gear and intensities relevant to future management of trawling in a Swedish fjord. Three trawled and three control sites were sampled at several times before and after trawling was initiated. This paper describes how conclusions about effects of trawling might differ between experiments involving replicate sites and experiments using only one trawled and one control site, as in several recent studies. Analyses of selected taxa showed that abundances of many species changed differently among control sites. Differences in temporal change between pairs of single trawled and control sites were also frequent. Neither the quantitative nor the qualitative nature of differences between treatments could, however, be coherently interpreted among the different combinations of trawled and control sites. This is consistent with results obtained from analyses using all sites, which showed no consistent effects of trawling on any of these taxa. These results provide empirical evidence that spatial confounding may cause serious problems to formal interpretation of experiments, which use only one control and one trawled area. Such potential problems can best be solved by ensuring that the study incorporates more than one control site.

Methods, applications, interpretations and challenges of interrupted time series (ITS) data: protocol for a scoping review.

PubMed

Ewusie, Joycelyne E; Blondal, Erik; Soobiah, Charlene; Beyene, Joseph; Thabane, Lehana; Straus, Sharon E; Hamid, Jemila S

2017-07-02

Interrupted time series (ITS) design involves collecting data across multiple time points before and after the implementation of an intervention to assess the effect of the intervention on an outcome. ITS designs have become increasingly common in recent times with frequent use in assessing impact of evidence implementation interventions. Several statistical methods are currently available for analysing data from ITS designs; however, there is a lack of guidance on which methods are optimal for different data types and on their implications in interpreting results. Our objective is to conduct a scoping review of existing methods for analysing ITS data, to summarise their characteristics and properties, as well as to examine how the results are reported. We also aim to identify gaps and methodological deficiencies. We will search electronic databases from inception until August 2016 (eg, MEDLINE and JSTOR). Two reviewers will independently screen titles, abstracts and full-text articles and complete the data abstraction. The anticipated outcome will be a summarised description of all the methods that have been used in analysing ITS data in health research, how those methods were applied, their strengths and limitations and the transparency of interpretation/reporting of the results. We will provide summary tables of the characteristics of the included studies. We will also describe the similarities and differences of the various methods. Ethical approval is not required for this study since we are just considering the methods used in the analysis and there will not be identifiable patient data. Results will be disseminated through open access peer-reviewed publications. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Ventilation/perfusion SPECT/CT in patients with pulmonary emphysema. Evaluation of software-based analysing.

PubMed

Schreiter, V; Steffen, I; Huebner, H; Bredow, J; Heimann, U; Kroencke, T J; Poellinger, A; Doellinger, F; Buchert, R; Hamm, B; Brenner, W; Schreiter, N F

2015-01-01

The purpose of this study was to evaluate the reproducibility of a new software based analysing system for ventilation/perfusion single-photon emission computed tomography/computed tomography (V/P SPECT/CT) in patients with pulmonary emphysema and to compare it to the visual interpretation. 19 patients (mean age: 68.1 years) with pulmonary emphysema who underwent V/P SPECT/CT were included. Data were analysed by two independent observers in visual interpretation (VI) and by software based analysis system (SBAS). SBAS PMOD version 3.4 (Technologies Ltd, Zurich, Switzerland) was used to assess counts and volume per lung lobe/per lung and to calculate the count density per lung, lobe ratio of counts and ratio of count density. VI was performed using a visual scale to assess the mean counts per lung lobe. Interobserver variability and association for SBAS and VI were analysed using Spearman's rho correlation coefficient. Interobserver agreement correlated highly in perfusion (rho: 0.982, 0.957, 0.90, 0.979) and ventilation (rho: 0.972, 0.924, 0.941, 0.936) for count/count density per lobe and ratio of counts/count density in SBAS. Interobserver agreement correlated clearly for perfusion (rho: 0.655) and weakly for ventilation (rho: 0.458) in VI. SBAS provides more reproducible measures than VI for the relative tracer uptake in V/P SPECT/CTs in patients with pulmonary emphysema. However, SBAS has to be improved for routine clinical use.

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies.

PubMed

Beekhuijzen, Manon; Schneider, Steffen; Barraclough, Narinder; Hallmark, Nina; Hoberman, Alan; Lordi, Sheri; Moxon, Mary; Perks, Deborah; Piersma, Aldert H; Makris, Susan L

2018-05-02

In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward. Copyright © 2018 Elsevier Inc. All rights reserved.

DSC of human hair: a tool for claim support or incorrect data analysis?

PubMed

Popescu, C; Gummer, C

2016-10-01

Differential scanning calorimetry (DSC) data are increasingly used to substantiate product claims of hair repair. Decreasing peak temperatures may indicate structural changes and chemical damage. Increasing the DSC, wet peak temperature is, therefore, often considered as proof of hair repair. A detailed understanding of the technique and hair structure indicates that this may not be a sound approach. Surveying the rich literature on the use of dynamic thermal analysis (DTA) and differential scanning calorimetry (DSC) for the analyses of human hair and the effect of cosmetic treatments, we underline some of the problems of hair structure and data interpretation. To overcome some of the difficulties of data interpretation, we advise that DSC acquired data should be supported by other techniques when used for claim substantiation. In this way, one can provide meaningful interpretation of the hair science and robust data for product claims support. © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Arabic-speaking migrants’ experiences of the use of interpreters in healthcare: a qualitative explorative study

PubMed Central

2014-01-01

Introduction Arabic-speaking migrants have constituted a growing population in recent years. This entails major challenges to ensure good communication in the healthcare encounter in order to provide individual and holistic healthcare. One of the solutions to ensure good communication between patient and healthcare staff who do not share the same language is to use a professional interpreter. To our knowledge, no previous qualitative studies have been found concerning Arabic-speaking migrants and the use of interpreters. This study aims to ascertain their individual experiences which can help extend our understanding of the studied area. Method A purposive sample of 13 Arabic-speaking persons with experience of using interpreters in healthcare encounters. Data were collected between November 2012 and March 2013 by four focus-group interviews and analysed with qualitative analysis according to a method described for focus groups. Results Four categories appeared from the analysis: 1) The professional interpreter as spokesperson; 2) Different types of interpreters and modes of interpretation adapting to the healthcare encounter; 3) The professional interpreter’s task and personal properties affected the use of professional interpreters in a healthcare encounter; 4) Future planning of the use of professional interpreters in a healthcare encounter. The main findings were that the use of interpreters was experienced both as a possibility and as a problem. The preferred type of interpreters depended on the interpreter’s dialect and ability to interpret correctly. Besides the professional interpreter’s qualities of good skill in language and medical terminology, translation ability, neutrality and objectivity, Arabic-speaking participants stated that professional interpreters need to share the same origin, religion, dialect, gender and political views as the patient in order to facilitate the interpreter use and avoid inappropriate treatment. Conclusion The study showed that the personal qualities of a good interpreter not only cover language ability but also origin, religion, dialect, gender and political views. Thus, there is need to develop strategies for personalized healthcare in order to avoid inappropriate communication, to satisfy the preferences of the person in need of interpreters and improve the impact of interpretation on the quality of healthcare. PMID:24934755

Steady-state and transient operation of a heat-pipe radiator system

NASA Technical Reports Server (NTRS)

Sellers, J. P.

1974-01-01

Data obtained on a VCHP heat-pipe radiator system tested in a vacuum environment were studied. Analyses and interpretation of the steady-state results are presented along with an initial analysis of some of the transient data. Particular emphasis was placed on quantitative comparisons of the experimental data with computer model simulations. The results of the study provide a better understanding of the system but do not provide a complete explanation for the observed low VCHP performance and the relatively flat radiator panel temperature distribution. The results of the study also suggest hardware, software, and testing improvements.

Tradeoffs in the design of a system for high level language interpretation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osorio, F.C.C.; Patt, Y.N.

The problem of designing a system for high-level language interpretation (HLLI) is considered. First, a model of the design process is presented where several styles of design, e.g. turing machine interpretation, CISC architecture interpretation and RISC architecture interpretation are treated uniformly. Second, the most significant characteristics of HLLI are analysed in the context of different design styles, and some guidelines are presented on how to identify the most suitable design style for a given high-level language problem. 12 references.

The difference between trivial and scientific names: There were never any true cheetahs in North America.

PubMed

Faurby, S; Werdelin, L; Svenning, J C

2016-05-05

Dobrynin et al. (Genome Biol 16:277, 2015) recently published the complete genome of the cheetah (Acinonyx jubatus) and provided an exhaustive set of analyses supporting the famously low genetic variation in the species, known for several decades. Their genetic analyses represent state-of-the-art and we do not criticize them. However, their interpretation of the results is inconsistent with current knowledge of cheetah evolution. Dobrynin et al. suggest that the causes of the two inferred bottlenecks at ∼ 100,000 and 10,000 years ago were immigration by cheetahs from North America and end-Pleistocene megafauna extinction, respectively, but the first explanation is impossible and the second implausible.

New insights into human primordial germ cells and early embryonic development from single-cell analysis.

PubMed

Otte, Jörg; Wruck, Wasco; Adjaye, James

2017-08-01

Human preimplantation developmental studies are difficult to accomplish due to associated ethical and moral issues. Preimplantation cells are rare and exist only in transient cell states. From a single cell, it is very challenging to analyse the origination of the heterogeneity and complexity inherent to the human body. However, recent advances in single-cell technology and data analysis have provided new insights into the process of early human development and germ cell specification. In this Review, we examine the latest single-cell datasets of human preimplantation embryos and germ cell development, compare them to bulk cell analyses, and interpret their biological implications. © 2017 Federation of European Biochemical Societies.

Assessing the dependence of sensitivity and specificity on prevalence in meta-analysis

PubMed Central

Li, Jialiang; Fine, Jason P.

2011-01-01

We consider modeling the dependence of sensitivity and specificity on the disease prevalence in diagnostic accuracy studies. Many meta-analyses compare test accuracy across studies and fail to incorporate the possible connection between the accuracy measures and the prevalence. We propose a Pearson type correlation coefficient and an estimating equation–based regression framework to help understand such a practical dependence. The results we derive may then be used to better interpret the results from meta-analyses. In the biomedical examples analyzed in this paper, the diagnostic accuracy of biomarkers are shown to be associated with prevalence, providing insights into the utility of these biomarkers in low- and high-prevalence populations. PMID:21525421

Brüstle v. Greenpeace: Implications for Commercialisation of Translational Stem Cell Research.

PubMed

Mansnérus, Juli

2015-04-01

The lack of consensus on a common definition of the term 'embryo' has resulted in legal uncertainty affecting the permissibility of human embryonic stem cell (hESC) research and the commercialisation prospects and patenting of inventions of hESC origin in the EU. The Brüstle v. Greenpeace case, which by providing a very broad definition of a human embryo restricts the patentability of hESC-based inventions, aims at harmonising the patenting practices regarding interpretation of Article 6.2.c of Directive 98/44/ EC. It fills the gaps in national laws by providing binding interpretation guidelines for national courts. As currently no marketing authorisations have been granted to hESC-based products, implications of this judgment for translational hESC research together with other barriers to commercialisation of such research need to be analysed. In addition, whether the main obstacles relate to patenting restrictions or whether something else in the innovation system is impeding the market entry of these innovative products is discussed.

Application of multivariate statistical techniques in microbial ecology

PubMed Central

Paliy, O.; Shankar, V.

2016-01-01

Recent advances in high-throughput methods of molecular analyses have led to an explosion of studies generating large scale ecological datasets. Especially noticeable effect has been attained in the field of microbial ecology, where new experimental approaches provided in-depth assessments of the composition, functions, and dynamic changes of complex microbial communities. Because even a single high-throughput experiment produces large amounts of data, powerful statistical techniques of multivariate analysis are well suited to analyze and interpret these datasets. Many different multivariate techniques are available, and often it is not clear which method should be applied to a particular dataset. In this review we describe and compare the most widely used multivariate statistical techniques including exploratory, interpretive, and discriminatory procedures. We consider several important limitations and assumptions of these methods, and we present examples of how these approaches have been utilized in recent studies to provide insight into the ecology of the microbial world. Finally, we offer suggestions for the selection of appropriate methods based on the research question and dataset structure. PMID:26786791

The Eco-Behavioral Approach to Surveys and Social Accounts for Rural Communities: Exploratory Analyses and Interpretations of Roger G. Barker's Microdata from the Behavior Setting Survey of Midwest, Kansas in 1963-64.

ERIC Educational Resources Information Center

Fox, Karl A.

The concept of behavior settings--the environments shaping individual behavior--was originated by Roger Barker in 1950 in connection with his community surveys in a small Kansas town, code-named Midwest. This book seeks to provide rural social scientists with an understanding of Barker's eco-behavioral approach and proposed adaptations of it to…

Prescriptive models to support decision making in genetics.

PubMed

Pauker, S G; Pauker, S P

1987-01-01

Formal prescriptive models can help patients and clinicians better understand the risks and uncertainties they face and better formulate well-reasoned decisions. Using Bayes rule, the clinician can interpret pedigrees, historical data, physical findings and laboratory data, providing individualized probabilities of various diagnoses and outcomes of pregnancy. With the advent of screening programs for genetic disease, it becomes increasingly important to consider the prior probabilities of disease when interpreting an abnormal screening test result. Decision trees provide a convenient formalism for structuring diagnostic, therapeutic and reproductive decisions; such trees can also enhance communication between clinicians and patients. Utility theory provides a mechanism for patients to understand the choices they face and to communicate their attitudes about potential reproductive outcomes in a manner which encourages the integration of those attitudes into appropriate decisions. Using a decision tree, the relevant probabilities and the patients' utilities, physicians can estimate the relative worth of various medical and reproductive options by calculating the expected utility of each. By performing relevant sensitivity analyses, clinicians and patients can understand the impact of various soft data, including the patients' attitudes toward various health outcomes, on the decision making process. Formal clinical decision analytic models can provide deeper understanding and improved decision making in clinical genetics.

Hydrogeologic applications for historical records and images from rock samples collected at the Nevada National Security Site and vicinity, Nye County, Nevada - A supplement to Data Series 297

USGS Publications Warehouse

Wood, David B.

2018-03-14

Rock samples have been collected, analyzed, and interpreted from drilling and mining operations at the Nevada National Security Site for over one-half of a century. Records containing geologic and hydrologic analyses and interpretations have been compiled into a series of databases. Rock samples have been photographed and thin sections scanned. Records and images are preserved and available for public viewing and downloading at the U.S. Geological Survey ScienceBase, Mercury Core Library and Data Center Web site at https://www.sciencebase.gov/mercury/ and documented in U.S. Geological Survey Data Series 297. Example applications of these data and images are provided in this report.

Acceleration of Convergence to Equilibrium in Markov Chains by Breaking Detailed Balance

NASA Astrophysics Data System (ADS)

Kaiser, Marcus; Jack, Robert L.; Zimmer, Johannes

2017-07-01

We analyse and interpret the effects of breaking detailed balance on the convergence to equilibrium of conservative interacting particle systems and their hydrodynamic scaling limits. For finite systems of interacting particles, we review existing results showing that irreversible processes converge faster to their steady state than reversible ones. We show how this behaviour appears in the hydrodynamic limit of such processes, as described by macroscopic fluctuation theory, and we provide a quantitative expression for the acceleration of convergence in this setting. We give a geometrical interpretation of this acceleration, in terms of currents that are antisymmetric under time-reversal and orthogonal to the free energy gradient, which act to drive the system away from states where (reversible) gradient-descent dynamics result in slow convergence to equilibrium.

Insights into crustal structure of the Eastern North American Margin from community multichannel seismic and potential field data

NASA Astrophysics Data System (ADS)

Davis, J. K.; Becel, A.; Shillington, D. J.; Buck, W. R.

2017-12-01

In the fall of 2014, the R/V Marcus Langseth collected gravity, magnetic, and reflection seismic data as part of the Eastern North American Margin Community Seismic Experiment. The dataset covers a 500 km wide section of the Mid-Atlantic passive margin offshore North Carolina, which formed after the Mesozoic breakup of the supercontinent Pangaea. Using these seismic and potential field data, we present observations and interpretations along two cross margin and one along-margin profiles. Analyses and interpretations are conducted using pre-stack depth migrated reflection seismic profiles in conjunction with forward modeling of shipboard gravity and magnetic anomalies. Preliminary interpretations of the data reveal variations in basement character and structure across the entire transition between continental and oceanic domains. These interpretations help provide insight into the origin and nature of the prominent East Coast and Blake Spur magnetic anomalies, as well as the Inner Magnetic Quiet Zone which occupies the domain between the anomalies. Collectively, these observations can aid in deciphering the rift-to-drift transition during the breakup of North America and West Africa and formation of the Central Atlantic.

On the interpretation of domain averaged Fermi hole analyses of correlated wavefunctions.

PubMed

Francisco, E; Martín Pendás, A; Costales, Aurora

2014-03-14

Few methods allow for a physically sound analysis of chemical bonds in cases where electron correlation may be a relevant factor. The domain averaged Fermi hole (DAFH) analysis, a tool firstly proposed by Robert Ponec in the 1990's to provide interpretations of the chemical bonding existing between two fragments Ω and Ω' that divide the real space exhaustively, is one of them. This method allows for a partition of the delocalization index or bond order between Ω and Ω' into one electron contributions, but the chemical interpretation of its parameters has been firmly established only for single determinant wavefunctions. In this paper we report a general interpretation based on the concept of excluded density that is also valid for correlated descriptions. Both analytical models and actual computations on a set of simple molecules (H2, N2, LiH, and CO) are discussed, and a classification of the possible DAFH situations is presented. Our results show that this kind of analysis may reveal several correlated assisted bonding patterns that might be difficult to detect using other methods. In agreement with previous knowledge, we find that the effective bond order in covalent links decreases due to localization of electrons driven by Coulomb correlation.

Presentation approaches for enhancing interpretability of patient-reported outcomes (PROs) in meta-analysis: a protocol for a systematic survey of Cochrane reviews.

PubMed

Devji, Tahira; Johnston, Bradley C; Patrick, Donald L; Bhandari, Mohit; Thabane, Lehana; Guyatt, Gordon H

2017-09-27

Meta-analyses of clinical trials often provide sufficient information for decision-makers to evaluate whether chance can explain apparent differences between interventions. Interpretation of the magnitude and importance of treatment effects beyond statistical significance can, however, be challenging, particularly for patient-reported outcomes (PROs) measured using questionnaires with which clinicians have limited familiarity. The objectives of our study are to systematically evaluate Cochrane systematic review authors' approaches to calculation, reporting and interpretation of pooled estimates of patient-reported outcome measures (PROMs) in meta-analyses. We will conduct a methodological survey of a random sample of Cochrane systematic reviews published from 1 January 2015 to 1 April 2017 that report at least one statistically significant pooled result for at least one PRO in the abstract. Author pairs will independently review all titles, abstracts and full texts identified by the literature search, and they will extract data using a standardised data extraction form. We will extract the following: year of publication, number of included trials, number of included participants, clinical area, type of intervention(s) and control(s), type of meta-analysis and use of the Grading of Recommendations, Assessment, Development and Evaluation approach to rate the quality of evidence, as well as information regarding the characteristics of PROMs, calculation and presentation of PROM effect estimates and interpretation of PROM effect estimates. We will document and summarise the methods used for the analysis, reporting and interpretation of each summary effect measure. We will summarise categorical variables with frequencies and percentages and continuous outcomes as means and/or medians and associated measures of dispersion. Ethics approval for this study is not required. We will disseminate the results of this review in peer-reviewed publications and conference presentations. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

On the scale dependence of earthquake stress drop

NASA Astrophysics Data System (ADS)

Cocco, Massimo; Tinti, Elisa; Cirella, Antonella

2016-10-01

We discuss the debated issue of scale dependence in earthquake source mechanics with the goal of providing supporting evidence to foster the adoption of a coherent interpretative framework. We examine the heterogeneous distribution of source and constitutive parameters during individual ruptures and their scaling with earthquake size. We discuss evidence that slip, slip-weakening distance and breakdown work scale with seismic moment and are interpreted as scale dependent parameters. We integrate our estimates of earthquake stress drop, computed through a pseudo-dynamic approach, with many others available in the literature for both point sources and finite fault models. We obtain a picture of the earthquake stress drop scaling with seismic moment over an exceptional broad range of earthquake sizes (-8 < MW < 9). Our results confirm that stress drop values are scattered over three order of magnitude and emphasize the lack of corroborating evidence that stress drop scales with seismic moment. We discuss these results in terms of scale invariance of stress drop with source dimension to analyse the interpretation of this outcome in terms of self-similarity. Geophysicists are presently unable to provide physical explanations of dynamic self-similarity relying on deterministic descriptions of micro-scale processes. We conclude that the interpretation of the self-similar behaviour of stress drop scaling is strongly model dependent. We emphasize that it relies on a geometric description of source heterogeneity through the statistical properties of initial stress or fault-surface topography, in which only the latter is constrained by observations.

Satellite Earth observation data to identify anthropogenic pressures in selected protected areas

NASA Astrophysics Data System (ADS)

Nagendra, Harini; Mairota, Paola; Marangi, Carmela; Lucas, Richard; Dimopoulos, Panayotis; Honrado, João Pradinho; Niphadkar, Madhura; Mücher, Caspar A.; Tomaselli, Valeria; Panitsa, Maria; Tarantino, Cristina; Manakos, Ioannis; Blonda, Palma

2015-05-01

Protected areas are experiencing increased levels of human pressure. To enable appropriate conservation action, it is critical to map and monitor changes in the type and extent of land cover/use and habitat classes, which can be related to human pressures over time. Satellite Earth observation (EO) data and techniques offer the opportunity to detect such changes. Yet association with field information and expert interpretation by ecologists is required to interpret, qualify and link these changes to human pressure. There is thus an urgent need to harmonize the technical background of experts in the field of EO data analysis with the terminology of ecologists, protected area management authorities and policy makers in order to provide meaningful, context-specific value-added EO products. This paper builds on the DPSIR framework, providing a terminology to relate the concepts of state, pressures, and drivers with the application of EO analysis. The type of pressure can be inferred through the detection of changes in state (i.e. changes in land cover and/or habitat type and/or condition). Four broad categories of changes in state are identified, i.e. land cover/habitat conversion, land cover/habitat modification, habitat fragmentation and changes in landscape connectivity, and changes in plant community structure. These categories of change in state can be mapped through EO analyses, with the goal of using expert judgement to relate changes in state to causal direct anthropogenic pressures. Drawing on expert knowledge, a set of protected areas located in diverse socio-ecological contexts and subject to a variety of pressures are analysed to (a) link the four categories of changes in state of land cover/habitats to the drivers (anthropogenic pressure), as relevant to specific target land cover and habitat classes; (b) identify (for pressure mapping) the most appropriate spatial and temporal EO data sources as well as interpretations from ecologists and field data useful in connection with EO data analysis. We provide detailed examples for two protected areas, demonstrating the use of EO data for detection of land cover/habitat change, coupled with expert interpretation to relate such change to specific anthropogenic pressures. We conclude with a discussion of the limitations and feasibility of using EO data and techniques to identify anthropogenic pressures, suggesting additional research efforts required in this direction.

Integration of genomic medicine into pathology residency training: the stanford open curriculum.

PubMed

Schrijver, Iris; Natkunam, Yasodha; Galli, Stephen; Boyd, Scott D

2013-03-01

Next-generation sequencing methods provide an opportunity for molecular pathology laboratories to perform genomic testing that is far more comprehensive than single-gene analyses. Genome-based test results are expected to develop into an integral component of diagnostic clinical medicine and to provide the basis for individually tailored health care. To achieve these goals, rigorous interpretation of high-quality data must be informed by the medical history and the phenotype of the patient. The discipline of pathology is well positioned to implement genome-based testing and to interpret its results, but new knowledge and skills must be included in the training of pathologists to develop expertise in this area. Pathology residents should be trained in emerging technologies to integrate genomic test results appropriately with more traditional testing, to accelerate clinical studies using genomic data, and to help develop appropriate standards of data quality and evidence-based interpretation of these test results. We have created a genomic pathology curriculum as a first step in helping pathology residents build a foundation for the understanding of genomic medicine and its implications for clinical practice. This curriculum is freely accessible online. Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

New geomorphic data on the active Taiwan orogen: A multisource approach

NASA Technical Reports Server (NTRS)

Deffontaines, B.; Lee, J.-C.; Angelier, J.; Carvalho, J.; Rudant, J.-P.

1994-01-01

A multisource and multiscale approach of Taiwan morphotectonics combines different complementary geomorphic analyses based on a new elevation model (DEM), side-looking airborne radar (SLAR), and satellite (SPOT) imagery, aerial photographs, and control from independent field data. This analysis enables us not only to present an integrated geomorphic description of the Taiwan orogen but also to highlight some new geodynamic aspects. Well-known, major geological structures such as the Longitudinal Valley, Lishan, Pingtung, and the Foothills fault zones are of course clearly recognized, but numerous, previously unrecognized structures appear distributed within different regions of Taiwan. For instance, transfer fault zones within the Western Foothills and the Central Range are identified based on analyses of lineaments and general morphology. In many cases, the existence of geomorphic features identified in general images is supported by the results of geological field analyses carried out independently. In turn, the field analyses of structures and mechanisms at some sites provide a key for interpreting similar geomorphic featues in other areas. Examples are the conjugate pattern of strike-slip faults within the Central Range and the oblique fold-and-thrust pattern of the Coastal Range. Furthermore, neotectonic and morphological analyses (drainage and erosional surfaces) has been combined in order to obtain a more comprehensive description and interpretation of neotectonic features in Taiwan, such as for the Longitudinal Valley Fault. Next, at a more general scale, numerical processing of digital elevation models, resulting in average topography, summit level or base level maps, allows identification of major features related to the dynamics of uplift and erosion and estimates of erosion balance. Finally, a preliminary morphotectonic sketch map of Taiwan, combining information from all the sources listed above, is presented.

A design space exploration for control of Critical Quality Attributes of mAb.

PubMed

Bhatia, Hemlata; Read, Erik; Agarabi, Cyrus; Brorson, Kurt; Lute, Scott; Yoon, Seongkyu

2016-10-15

A unique "design space (DSp) exploration strategy," defined as a function of four key scenarios, was successfully integrated and validated to enhance the DSp building exercise, by increasing the accuracy of analyses and interpretation of processed data. The four key scenarios, defining the strategy, were based on cumulative analyses of individual models developed for the Critical Quality Attributes (23 Glycan Profiles) considered for the study. The analyses of the CQA estimates and model performances were interpreted as (1) Inside Specification/Significant Model (2) Inside Specification/Non-significant Model (3) Outside Specification/Significant Model (4) Outside Specification/Non-significant Model. Each scenario was defined and illustrated through individual models of CQA aligning the description. The R(2), Q(2), Model Validity and Model Reproducibility estimates of G2, G2FaGbGN, G0 and G2FaG2, respectively, signified the four scenarios stated above. Through further optimizations, including the estimation of Edge of Failure and Set Point Analysis, wider and accurate DSps were created for each scenario, establishing critical functional relationship between Critical Process Parameters (CPPs) and Critical Quality Attributes (CQAs). A DSp provides the optimal region for systematic evaluation, mechanistic understanding and refining of a QbD approach. DSp exploration strategy will aid the critical process of consistently and reproducibly achieving predefined quality of a product throughout its lifecycle. Copyright © 2016 Elsevier B.V. All rights reserved.

Population Genomics of Fungal and Oomycete Pathogens.

PubMed

Grünwald, Niklaus J; McDonald, Bruce A; Milgroom, Michael G

2016-08-04

We are entering a new era in plant pathology in which whole-genome sequences of many individuals of a pathogen species are becoming readily available. Population genomics aims to discover genetic mechanisms underlying phenotypes associated with adaptive traits such as pathogenicity, virulence, fungicide resistance, and host specialization, as genome sequences or large numbers of single nucleotide polymorphisms become readily available from multiple individuals of the same species. This emerging field encompasses detailed genetic analyses of natural populations, comparative genomic analyses of closely related species, identification of genes under selection, and linkage analyses involving association studies in natural populations or segregating populations resulting from crosses. The era of pathogen population genomics will provide new opportunities and challenges, requiring new computational and analytical tools. This review focuses on conceptual and methodological issues as well as the approaches to answering questions in population genomics. The major steps start with defining relevant biological and evolutionary questions, followed by sampling, genotyping, and phenotyping, and ending in analytical methods and interpretations. We provide examples of recent applications of population genomics to fungal and oomycete plant pathogens.

Characterization of structures of the Nankai Trough accretionary prism from integrated analyses of LWD log response, resistivity images and clay mineralogy of cuttings: Expedition 338 Site C0002

NASA Astrophysics Data System (ADS)

Jurado, Maria Jose; Schleicher, Anja

2014-05-01

The objective of our research is a detailed characterization of structures on the basis of LWD oriented images and logs,and clay mineralogy of cuttings from Hole C0002F of the Nankai Trough accretionary prism. Our results show an integrated interpretation of structures derived from borehole images, petrophysical characterization on LWD logs and cuttings mineralogy. The geometry of the structure intersected at Hole C0002F has been characterized by the interpretation of oriented borehole resistivity images acquired during IODP Expedition 338. The characterization of structural features, faults and fracture zones is based on a detailed post-cruise interpretation of bedding and fractures on borehole images and also on the analysis of Logging While Drilling (LWD) log response (gamma radioactivity, resistivity and sonic logs). The interpretation and complete characterization of structures (fractures, fracture zones, fault zones, folds) was achieved after detailed shorebased reprocessing of resistivity images, which allowed to enhance bedding and fracture's imaging for geometry and orientation interpretation. In order to characterize distinctive petrophysical properties based on LWD log response, it could be compared with compositional changes derived from cuttings analyses. Cuttings analyses were used to calibrate and to characterize log response and to verify interpretations in terms of changes in composition and texture at fractures and fault zones defined on borehole images. Cuttings were taken routinely every 5 m during Expedition 338, indicating a clay-dominated lithology of silty claystone with interbeds of weakly consolidated, fine sandstones. The main mineralogical components are clay minerals, quartz, feldspar and calcite. Selected cuttings were taken from areas of interest as defined on LWD logs and images. The clay mineralogy was investigated on the <2 micron clay-size fraction, with special focus on smectite and illite minerals. Based on X-ray diffraction analysis measured at room temperature and a relative humidity of ~30%, we compared the shape and size of illite and smectite, as well as their water content and their polytypes. The comparison of cuttings mineralogy with logging while drilling (LWD) data allowed us to characterize structural, petrophysical and mineralogical properties at fracture and fault zones. We also analyzed the relationship between deformation structures and compositional and mineralogical changes. We established a correlation between observed results on clay mineralogy and log responses in relation with the structures and trends characterized on logging data. In general, the log data provide a good correlation with the actual mineralogy and the relative abundance of clay. In particular we analyzed trends characterized by smectite water layers as indication of compaction. These trends were correlated with log response (on sonic velocity) within Unit IV. Our results show the integration of logging data and cutting sample analyses as a valuable tool for characterization of petrophysical and mineralogical changes of the structures of the Nankai accretionary prism.

Updating Parameters for Volcanic Hazard Assessment Using Multi-parameter Monitoring Data Streams And Bayesian Belief Networks

NASA Astrophysics Data System (ADS)

Odbert, Henry; Aspinall, Willy

2014-05-01

Evidence-based hazard assessment at volcanoes assimilates knowledge about the physical processes of hazardous phenomena and observations that indicate the current state of a volcano. Incorporating both these lines of evidence can inform our belief about the likelihood (probability) and consequences (impact) of possible hazardous scenarios, forming a basis for formal quantitative hazard assessment. However, such evidence is often uncertain, indirect or incomplete. Approaches to volcano monitoring have advanced substantially in recent decades, increasing the variety and resolution of multi-parameter timeseries data recorded at volcanoes. Interpreting these multiple strands of parallel, partial evidence thus becomes increasingly complex. In practice, interpreting many timeseries requires an individual to be familiar with the idiosyncrasies of the volcano, monitoring techniques, configuration of recording instruments, observations from other datasets, and so on. In making such interpretations, an individual must consider how different volcanic processes may manifest as measureable observations, and then infer from the available data what can or cannot be deduced about those processes. We examine how parts of this process may be synthesised algorithmically using Bayesian inference. Bayesian Belief Networks (BBNs) use probability theory to treat and evaluate uncertainties in a rational and auditable scientific manner, but only to the extent warranted by the strength of the available evidence. The concept is a suitable framework for marshalling multiple strands of evidence (e.g. observations, model results and interpretations) and their associated uncertainties in a methodical manner. BBNs are usually implemented in graphical form and could be developed as a tool for near real-time, ongoing use in a volcano observatory, for example. We explore the application of BBNs in analysing volcanic data from the long-lived eruption at Soufriere Hills Volcano, Montserrat. We discuss the uncertainty of inferences, and how our method provides a route to formal propagation of uncertainties in hazard models. Such approaches provide an attractive route to developing an interface between volcano monitoring analyses and probabilistic hazard scenario analysis. We discuss the use of BBNs in hazard analysis as a tractable and traceable tool for fast, rational assimilation of complex, multi-parameter data sets in the context of timely volcanic crisis decision support.

QED (quantum-electrodynamical) theory of excess spontaneous emission noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milonni, P.W.

1990-01-01

The results of a quantum-electrodynamical theory of excess spontaneous emission noise in lossy resonators will be presented. The Petermann K factor'' does not enter into the spontaneous emission rate of a single atom in the cavity. The QED theory allows different interpretations of the K factor, and we use this fact to justify semiclassical analyses and to provide in one example a simple derivation of K in terms of the amplification of the quantum vacuum field entering the resonator through its mirrors. 17 refs.

Technical basis for nuclear accident dosimetry at the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerr, G.D.; Mei, G.T.

The Oak Ridge National Laboratory (ORNL) Environmental, Safety, and Health Emergency Response Organization has the responsibility of providing analyses of personnel exposures to neutrons and gamma rays from a nuclear accident. This report presents the technical and philosophical basis for the dose assessment aspects of the nuclear accident dosimetry (NAD) system at ORNL. The issues addressed are regulatory guidelines, ORNL NAD system components and performance, and the interpretation of dosimetric information that would be gathered following a nuclear accident.

Not all are desired: providers' views on interpreters' emotional support for patients.

PubMed

Hsieh, Elaine; Hong, Soo Jung

2010-11-01

This study examines (a) providers' expectations and concerns for interpreters' emotional support, and (b) the complexity and dilemma for interpreters to offer emotional support in health care settings. We recruited 39 providers from 5 specialties to participate in in-depth interviews or focus groups. Grounded theory was used for data analysis to identify providers' expectations and concerns for interpreters' emotional support. From the providers' perspective, interpreters' emotional support: (a) is embodied through their physical presence, (b) is to be both a human being but also a professional, (c) represents the extension of the providers' care, and (d) imposes potential risks to quality of care. Emotional support in bilingual health care is accomplished through the alliance of providers and interpreters, complementing each other to support patients' emotional needs. Interpreters should be vigilant about how their emotional support may impact the provider-patient relationship and the providers' therapeutic objectives. Interpreters should be aware that providers also rely on them to provide emotional support, which highlights the importance of giving medical talk and rapport-building talk equal attention in medical encounters. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Research as Praxis: Perspectives on Interpreting Data from a Science and Indigenous Knowledge Systems Project

ERIC Educational Resources Information Center

Nhalevilo, Emilia Afonso; Ogunniyi, Meshach

2014-01-01

This article presents a reflection on an aspect of research methodology, particularly on the interpretation strategy of data from a Science and Indigenous Knowledge Systems Project (SIKSP) in a South African university. The data interpretation problem arose while we were analysing the effects of a series of SIKSP-based workshops on the views of a…

Too close to home? Experiences of Kurdish refugee interpreters working in UK mental health services.

PubMed

Green, Hannah; Sperlinger, David; Carswell, Kenneth

2012-06-01

Despite their essential role in the National Health Service, there is limited research on the experiences of refugee interpreters. To explore Kurdish refugee interpreters' experiences of working in UK mental health services. Six participants were interviewed and data collected were analysed using interpretative phenomenological analysis. The results showed that interpreters often felt overwhelmed by the emotional impact of interpreting in mental health services, particularly at the beginning of their careers. Interpreters struggled to negotiate complex and unclear roles and responsibilities. Interpreting for refugees with shared histories was particularly challenging. The study recommends that interpreters working in mental health services receive training on mental health issues and self-care and are assisted by frameworks to help make sense of the impact of the work, such as supervision.

Cued Speech Transliteration: Effects of Speaking Rate and Lag Time on Production Accuracy.

PubMed

Krause, Jean C; Tessler, Morgan P

2016-10-01

Many deaf and hard-of-hearing children rely on interpreters to access classroom communication. Although the exact level of access provided by interpreters in these settings is unknown, it is likely to depend heavily on interpreter accuracy (portion of message correctly produced by the interpreter) and the factors that govern interpreter accuracy. In this study, the accuracy of 12 Cued Speech (CS) transliterators with varying degrees of experience was examined at three different speaking rates (slow, normal, fast). Accuracy was measured with a high-resolution, objective metric in order to facilitate quantitative analyses of the effect of each factor on accuracy. Results showed that speaking rate had a large negative effect on accuracy, caused primarily by an increase in omitted cues, whereas the effect of lag time on accuracy, also negative, was quite small and explained just 3% of the variance. Increased experience level was generally associated with increased accuracy; however, high levels of experience did not guarantee high levels of accuracy. Finally, the overall accuracy of the 12 transliterators, 54% on average across all three factors, was low enough to raise serious concerns about the quality of CS transliteration services that (at least some) children receive in educational settings. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A Qualitative study of language barriers between South African health care providers and cross-border migrants.

PubMed

Hunter-Adams, Jo; Rother, Hanna-Andrea

2017-01-31

Communication with health care providers represents an essential part of access to health care for the over 230 million cross-border migrants around the world. In this article, we explore the complexity of health communication from the perspective of cross-border migrants seeking antenatal care in Cape Town, South Africa in order to highlight the importance of high quality medical interpretation. As part of a broader study of migrant maternal and infant nutrition, we conducted a secondary data analysis of semi-structured in-depth interviews (N = 23) with Congolese (n = 7), Somali (n = 8) and Zimbabwean (n = 8) women living in Cape Town, as well as nine focus group discussions (including men: n = 3 and women: n = 6) were conducted with migrant Somalis, Congolese, and Zimbabweans (N = 48). We first used content analysis to gather all data related to language and communication. We then analysed this data thematically. Zimbabwean participants described how the inability to speak the local South African language (IsiXhosa) gave rise to labelling and stereotyping by healthcare staff. Congolese and Somali participants described medical procedures, including tubal ligation, which were performed without consent. Partners often tried to play the role of interpreter, which resulted in loss of income and non-professional medical interpretation. Participants' highlighted fears over unwanted procedures or being unable to access care. Challenges of communication without a common language (and without professional medical interpretation), rather than outright denial of care by healthcare professionals, mediated these encounters. Although there are several factors impeding cross-border migrants' access to health care, effective communication is a prerequisite for quality care. Free-to-patient professional medical interpretation would not only benefit migrant populations but would benefit the broader community where language and health literacy are barriers to accessing health care. Novel approaches to language access may include technology-enabled professional interpretation.

Spaceborne radar observations: A guide for Magellan radar-image analysis

NASA Technical Reports Server (NTRS)

Ford, J. P.; Blom, R. G.; Crisp, J. A.; Elachi, Charles; Farr, T. G.; Saunders, R. Stephen; Theilig, E. E.; Wall, S. D.; Yewell, S. B.

1989-01-01

Geologic analyses of spaceborne radar images of Earth are reviewed and summarized with respect to detecting, mapping, and interpreting impact craters, volcanic landforms, eolian and subsurface features, and tectonic landforms. Interpretations are illustrated mostly with Seasat synthetic aperture radar and shuttle-imaging-radar images. Analogies are drawn for the potential interpretation of radar images of Venus, with emphasis on the effects of variation in Magellan look angle with Venusian latitude. In each landform category, differences in feature perception and interpretive capability are related to variations in imaging geometry, spatial resolution, and wavelength of the imaging radar systems. Impact craters and other radially symmetrical features may show apparent bilateral symmetry parallel to the illumination vector at low look angles. The styles of eruption and the emplacement of major and minor volcanic constructs can be interpreted from morphological features observed in images. Radar responses that are governed by small-scale surface roughness may serve to distinguish flow types, but do not provide unambiguous information. Imaging of sand dunes is rigorously constrained by specific angular relations between the illumination vector and the orientation and angle of repose of the dune faces, but is independent of radar wavelength. With a single look angle, conditions that enable shallow subsurface imaging to occur do not provide the information necessary to determine whether the radar has recorded surface or subsurface features. The topographic linearity of many tectonic landforms is enhanced on images at regional and local scales, but the detection of structural detail is a strong function of illumination direction. Nontopographic tectonic lineaments may appear in response to contrasts in small-surface roughness or dielectric constant. The breakpoint for rough surfaces will vary by about 25 percent through the Magellan viewing geometries from low to high Venusian latitudes. Examples of anomalies and system artifacts that can affect image interpretation are described.

How to Make Nothing Out of Something: Analyses of the Impact of Study Sampling and Statistical Interpretation in Misleading Meta-Analytic Conclusions

PubMed Central

Cunningham, Michael R.; Baumeister, Roy F.

2016-01-01

The limited resource model states that self-control is governed by a relatively finite set of inner resources on which people draw when exerting willpower. Once self-control resources have been used up or depleted, they are less available for other self-control tasks, leading to a decrement in subsequent self-control success. The depletion effect has been studied for over 20 years, tested or extended in more than 600 studies, and supported in an independent meta-analysis (Hagger et al., 2010). Meta-analyses are supposed to reduce bias in literature reviews. Carter et al.’s (2015) meta-analysis, by contrast, included a series of questionable decisions involving sampling, methods, and data analysis. We provide quantitative analyses of key sampling issues: exclusion of many of the best depletion studies based on idiosyncratic criteria and the emphasis on mini meta-analyses with low statistical power as opposed to the overall depletion effect. We discuss two key methodological issues: failure to code for research quality, and the quantitative impact of weak studies by novice researchers. We discuss two key data analysis issues: questionable interpretation of the results of trim and fill and Funnel Plot Asymmetry test procedures, and the use and misinterpretation of the untested Precision Effect Test and Precision Effect Estimate with Standard Error (PEESE) procedures. Despite these serious problems, the Carter et al. (2015) meta-analysis results actually indicate that there is a real depletion effect – contrary to their title. PMID:27826272

Static Analysis Using Abstract Interpretation

NASA Technical Reports Server (NTRS)

Arthaud, Maxime

2017-01-01

Short presentation about static analysis and most particularly abstract interpretation. It starts with a brief explanation on why static analysis is used at NASA. Then, it describes the IKOS (Inference Kernel for Open Static Analyzers) tool chain. Results on NASA projects are shown. Several well known algorithms from the static analysis literature are then explained (such as pointer analyses, memory analyses, weak relational abstract domains, function summarization, etc.). It ends with interesting problems we encountered (such as C++ analysis with exception handling, or the detection of integer overflow).

30 CFR 252.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

30 CFR 552.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

30 CFR 552.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

30 CFR 552.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

30 CFR 252.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

30 CFR 252.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... geophysical information. Interpreted geological information means knowledge, often in the form of schematic... geological information. Interpreted geophysical information means knowledge, often in the form of schematic...

Attention training through gaze-contingent feedback: Effects on reappraisal and negative emotions.

PubMed

Sanchez, Alvaro; Everaert, Jonas; Koster, Ernst H W

2016-10-01

Reappraisal is central to emotion regulation but its mechanisms are unclear. This study tested the theoretical prediction that emotional attention bias is linked to reappraisal of negative emotion-eliciting stimuli and subsequent emotional responding using a novel attentional control training. Thirty-six undergraduates were randomly assigned to either the control or the attention training condition and were provided with different task instructions while they performed an interpretation task. Whereas control participants freely created interpretations, participants in the training condition were instructed to allocate attention toward positive words to efficiently create positive interpretations (i.e., recruiting attentional control) while they were provided with gaze-contingent feedback on their viewing behavior. Transfer to attention bias and reappraisal success was evaluated using a dot-probe task and an emotion regulation task which were administered before and after the training. The training condition was effective at increasing attentional control and resulted in beneficial effects on the transfer tasks. Analyses supported a serial indirect effect with larger attentional control acquisition in the training condition leading to negative attention bias reduction, in turn predicting greater reappraisal success which reduced negative emotions. Our results indicate that attentional mechanisms influence the use of reappraisal strategies and its impact on negative emotions. The novel attention training highlights the importance of tailored feedback to train attentional control. The findings provide an important step toward personalized delivery of attention training. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The usefulness of videomanometry for studying pediatric esophageal motor disease.

PubMed

Kawahara, Hisayoshi; Kubota, Akio; Okuyama, Hiroomi; Oue, Takaharu; Tazuke, Yuko; Okada, Akira

2004-12-01

Abnormalities in esophageal motor function underlie various symptoms in the pediatric population. Manometry remains an important tool for studying esophageal motor function, whereas its analyses have been conducted with considerable subjective interpretation. The usefulness of videomanometry with topographic analysis was examined in the current study. Videomanometry was conducted in 5 patients with primary gastroesophageal reflux disease (GERD), 4 with postoperative esophageal atresia (EA), 1 with congenital esophageal stenosis (CES), and 1 with diffuse esophageal spasms (DES). Digitized videofluoroscopic images were recorded synchronously with manometric digital data in a personal computer. Manometric analysis was conducted with a view of concurrent esophageal contour and bolus transit. Primary GERD patients showed esophageal flow proceeding into the stomach during peristaltic contractions recorded manometrically, whereas patients with EA/CES frequently showed impaired esophageal transit during defective esophageal peristaltic contractions. A characteristic corkscrew appearance and esophageal flow in a to-and-fro fashion were seen with high-amplitude synchronous esophageal contractions in a DES patient. The topographic analysis showed distinctive images characteristic of each pathological condition. Videomanometry is helpful in interpreting manometric data by analyzing concurrent fluoroscopic images. Topographic analyses provide characteristic images reflecting motor abnormalities in pediatric esophageal disease.

Large and linked in scientific publishing

PubMed Central

2012-01-01

We are delighted to announce the launch of GigaScience, an online open-access journal that focuses on research using or producing large datasets in all areas of biological and biomedical sciences. GigaScience is a new type of journal that provides standard scientific publishing linked directly to a database that hosts all the relevant data. The primary goals for the journal, detailed in this editorial, are to promote more rapid data release, broader use and reuse of data, improved reproducibility of results, and direct, easy access between analyses and their data. Direct and permanent connections of scientific analyses and their data (achieved by assigning all hosted data a citable DOI) will enable better analysis and deeper interpretation of the data in the future. PMID:23587310

Large and linked in scientific publishing.

PubMed

Goodman, Laurie; Edmunds, Scott C; Basford, Alexandra T

2012-07-12

We are delighted to announce the launch of GigaScience, an online open-access journal that focuses on research using or producing large datasets in all areas of biological and biomedical sciences. GigaScience is a new type of journal that provides standard scientific publishing linked directly to a database that hosts all the relevant data. The primary goals for the journal, detailed in this editorial, are to promote more rapid data release, broader use and reuse of data, improved reproducibility of results, and direct, easy access between analyses and their data. Direct and permanent connections of scientific analyses and their data (achieved by assigning all hosted data a citable DOI) will enable better analysis and deeper interpretation of the data in the future.

Appraisal of ground water for irrigation in the Little Falls area, Morrison County, Minnesota

USGS Publications Warehouse

Helgesen, John O.

1973-01-01

Possible future response to pumping was studied through electric analog analyses by stressing the modeled aquifer system in accordance with areal variations in expected well yields. The model interpretation indicates most of the sustained pumpage would be obtained from intercepted base flow and evapotranspiration. Simulated withdrawals totaling 18,000 acre-feet of water per year for 10 years resulted in little adverse effect on the aquifer system. Simulated larger withdrawals, assumed to represent denser well spacing, caused greater depletion of aquifer storage, streamflow, and lake volumes, excessively so in some areas. Results of model analyses provide a guide for ground-water development by identifying the capability of all parts of the aquifer system to support sustained pumping for irrigation.

Biology Needs Evolutionary Software Tools: Let’s Build Them Right

PubMed Central

Team, Galaxy; Goecks, Jeremy; Taylor, James

2018-01-01

Abstract Research in population genetics and evolutionary biology has always provided a computational backbone for life sciences as a whole. Today evolutionary and population biology reasoning are essential for interpretation of large complex datasets that are characteristic of all domains of today’s life sciences ranging from cancer biology to microbial ecology. This situation makes algorithms and software tools developed by our community more important than ever before. This means that we, developers of software tool for molecular evolutionary analyses, now have a shared responsibility to make these tools accessible using modern technological developments as well as provide adequate documentation and training. PMID:29688462

Geologic and geochemical results from boreholes drilled in Yellowstone National Park, Wyoming, 2007 and 2008

USGS Publications Warehouse

Jaworowski, Cheryl; Susong, David; Heasler, Henry; Mencin, David; Johnson, Wade; Conrey, Rick; Von Stauffenberg, Jennipher

2016-06-01

After drilling the seven PBO boreholes, cuttings were examined and selected for preparation of grain mounts, thin sections, and geochemical analysis. Major ions and trace elements (including rare earth elements) of selected cuttings were determined by x-ray fluorescence (XRF) and inductively coupled plasma-mass spectrometry (ICP-MS); the ICP-MS provided more precise trace-element analysis than XRF. A preliminary interpretation of the results of geochemical analyses generally shows a correlation between borehole cuttings and previously mapped geology. The geochemical data and borehole stratigraphy presented in this report provide a foundation for future petrologic, geochemical, and geophysical studies.

Molecules as diagnostic tools in the interstellar medium

NASA Astrophysics Data System (ADS)

Spielfiedel, A.; Feautrier, N.; Balança, C.; Dayou, F.; Lique, F.; Senent, M.-L.

Analysis of light emission from different regions of the interstellar medium and circumstellar environments provides crucial information about the chemical composition and the physical conditions in these regions. Interpretation of the observed spectra requires the knowledge of collisional excitation rates as well as radiative rates participating to the line formation. In the first part, the paper focuses on collisional excitation rates of molecules relevant to the interstellar medium. It discusses currently available data and outlines new work carried out by the authors. Due to the use of accurate ab initio potential energy surfaces, the new rate coefficients differ significantly from previously published ones. In the second part, it is analysed from two examples how the use of the new rate coefficients could lead to important changes in the interpretation of molecular emission emerging from molecular clouds.

30 CFR 252.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... include, but is not limited to, identification of lithologic and fossil content, core analyses, laboratory... interpreted geophysical information. (l) Interpreted geological information means knowledge, often in the form... the form of schematic cross sections and maps, developed by determining the geological significance of...

Introduction to uses and interpretation of principal component analyses in forest biology.

Treesearch

J. G. Isebrands; Thomas R. Crow

1975-01-01

The application of principal component analysis for interpretation of multivariate data sets is reviewed with emphasis on (1) reduction of the number of variables, (2) ordination of variables, and (3) applications in conjunction with multiple regression.

OSIRIS-REx Asteroid Sample-Return Mission

NASA Astrophysics Data System (ADS)

DellaGiustina, D. N.; Lauretta, D. S.

2016-12-01

Launching in September 2016, the primary objective of the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission is to return a pristine sample of asteroid (101955) Bennu to Earth for sample analysis. Bennu is a carbonaceous primitive near-Earth object, and is expected to be rich in volatile and organic material leftover from the formation of the Solar System. OSIRIS-REx will return a minimum of 60 g of bulk surface material from this body using a novel "touch-and-go" sample acquisition mechanism. Analyses of these samples will provide unprecedented knowledge about presolar history, from the initial stages of planet formation to the origin of life. Before sample acquisition, OSIRIS-REx will perform global mapping of Bennu, detailing the asteroid's composition and texture, resolving surface features, revealing its geologic and dynamic history, and providing context for the returned samples. The mission will also document the sampling site in situ at sub-centimeter scales, as well as the asteroid sampling event. In addition, OSIRIS-REx will measure the Yarkovsky effect, a non-Keplerian force affecting the orbit of this potentially hazardous asteroid, and provide a ground truth data for the interpretation of telescopic observations of carbonaceous asteroids.

Geology and surface geochemistry of the Roosevelt Springs Known Geothermal Resource Area, Utah

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lovell, J.S.; Meyer, W.T.; Atkinson, D.J.

1980-01-01

Available data on the Roosevelt area were synthesized to determine the spatial arrangement of the rocks, and the patterns of mass and energy flow within them. The resulting model lead to a new interpretation of the geothermal system, and provided ground truth for evaluating the application of soil geochemistry to exploration for concealed geothermal fields. Preliminary geochemical studies comparing the surface microlayer to conventional soil sampling methods indicated both practical and chemical advantages for the surface microlayer technique, which was particularly evident in the case of As, Sb and Cs. Subsequent multi-element analyses of surface microlayer samples collected over anmore » area of 100 square miles were processed to produce single element contour maps for 41 chemical parameters. Computer manipulation of the multi-element data using R-mode factor analysis provided the optimum method of interpretation of the surface microlayer data. A trace element association of As, Sb and Cs in the surface microlayer provided the best indication of the leakage of geothermal solutions to the surface, while regional mercury trends may reflect the presence of a mercury vapour anomaly above a concealed heat source.« less

From "Double Vision" to Panorama: Using History of Memory to Bridge "Event Space" When Exploring Interpretations of Nazi Popularity with Year 13

ERIC Educational Resources Information Center

Carroll, James Edward

2017-01-01

Jim Carroll relished the opportunity, in the new A-level specification he was teaching, to find an effective way of teaching his students to analyse interpretations in their coursework essays. Reflecting on the difficulties he had faced as a trainee teacher teaching younger pupils about interpretations, and dissatisfied with examination board…

Anisotropy of magnetic susceptibility as a tool for recognizing core deformation: reevaluation of the paleomagnetic record of Pleistocene sediments from drill hole OL-92, Owens Lake, California

USGS Publications Warehouse

Rosenbaum, Joseph; Reynolds, Richard T.; Smoot, Joseph; Meyer, Robert

2000-01-01

At Owens Lake, California, paleomagnetic data document the Matuyama/Brunhes polarity boundary near the bottom of a 323-m core (OL-92) and display numerous directional fluctuations throughout the Brunhes chron. Many of the intervals of high directional dispersion were previously interpreted to record magnetic excursions. For the upper ~120 m, these interpretations were tested using the anisotropy of magnetic susceptibility (AMS), which typically defines a subhorizontal planar fabric for sediments deposited in quiet water. AMS data from intervals of deformed core, determined from detailed analysis of sedimentary structures, were compared to a reference AMS fabric derived from undisturbed sediment. This comparison shows that changes in the AMS fabric provide a means of screening core samples for deformation and the associated paleomagnetic record for the adverse effects of distortion. For that portion of core OL-92 studied here (about the upper 120 m), the combined analyses of sedimentary structures and AMS data demonstrate that most of the paleomagnetic features, previously interpreted as geomagnetic excursions, are likely the result of core deformation.

Factor structure of the Wechsler Intelligence Scale for Children-Fifth Edition: Exploratory factor analyses with the 16 primary and secondary subtests.

PubMed

Canivez, Gary L; Watkins, Marley W; Dombrowski, Stefan C

2016-08-01

The factor structure of the 16 Primary and Secondary subtests of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V; Wechsler, 2014a) standardization sample was examined with exploratory factor analytic methods (EFA) not included in the WISC-V Technical and Interpretive Manual (Wechsler, 2014b). Factor extraction criteria suggested 1 to 4 factors and results favored 4 first-order factors. When this structure was transformed with the Schmid and Leiman (1957) orthogonalization procedure, the hierarchical g-factor accounted for large portions of total and common variance while the 4 first-order factors accounted for small portions of total and common variance; rendering interpretation at the factor index level less appropriate. Although the publisher favored a 5-factor model where the Perceptual Reasoning factor was split into separate Visual Spatial and Fluid Reasoning dimensions, no evidence for 5 factors was found. It was concluded that the WISC-V provides strong measurement of general intelligence and clinical interpretation should be primarily, if not exclusively, at that level. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Understanding discharge data uncertainty and its consequences for analyses of spatial and temporal change in hydrological response

NASA Astrophysics Data System (ADS)

Westerberg, Ida

2017-04-01

Understanding and quantifying how hydrological response behaviour varies across catchments, or how catchments change with time requires reliable discharge data. For reliable estimation of spatial and temporal change, the change in the response behaviour needs to be larger than the uncertainty in the response behaviour estimates that are compared. Understanding how discharge data uncertainty varies between catchments and over time, and how these uncertainties propagate to information derived from the data, is therefore key to drawing the right conclusions in comparative analyses. Uncertainty in discharge data is often highly place-specific and reliable estimation depends on detailed analyses of the rating curve model and stage-discharge measurements used to calculate discharge time series from stage (water level) at the gauging station. This underlying information is often not available when discharge data is provided by monitoring agencies. However, even without detailed analyses, the chance that the discharge data would be uncertain at particular flow ranges can be assessed based on information about the gauging station, the flow regime, and the catchment. This type of information is often available for most catchments even if the rating curve data are not. Such 'soft information' on discharge uncertainty may aid interpretation of results from regional and temporal change analyses. In particular, it can help reduce the risk of wrongly interpreting differences in response behaviour caused by discharge uncertainty as real changes. In this presentation I draw on several previous studies to discuss some of the factors that affect discharge data uncertainty and give examples from catchments worldwide. I aim to 1) illustrate the consequences of discharge data uncertainty on comparisons of different types of hydrological response behaviour across catchments and when analysing temporal change, and 2) give practical advice as to what factors may help identify catchments with potentially large discharge uncertainty.

On the interpretation of weight vectors of linear models in multivariate neuroimaging.

PubMed

Haufe, Stefan; Meinecke, Frank; Görgen, Kai; Dähne, Sven; Haynes, John-Dylan; Blankertz, Benjamin; Bießmann, Felix

2014-02-15

The increase in spatiotemporal resolution of neuroimaging devices is accompanied by a trend towards more powerful multivariate analysis methods. Often it is desired to interpret the outcome of these methods with respect to the cognitive processes under study. Here we discuss which methods allow for such interpretations, and provide guidelines for choosing an appropriate analysis for a given experimental goal: For a surgeon who needs to decide where to remove brain tissue it is most important to determine the origin of cognitive functions and associated neural processes. In contrast, when communicating with paralyzed or comatose patients via brain-computer interfaces, it is most important to accurately extract the neural processes specific to a certain mental state. These equally important but complementary objectives require different analysis methods. Determining the origin of neural processes in time or space from the parameters of a data-driven model requires what we call a forward model of the data; such a model explains how the measured data was generated from the neural sources. Examples are general linear models (GLMs). Methods for the extraction of neural information from data can be considered as backward models, as they attempt to reverse the data generating process. Examples are multivariate classifiers. Here we demonstrate that the parameters of forward models are neurophysiologically interpretable in the sense that significant nonzero weights are only observed at channels the activity of which is related to the brain process under study. In contrast, the interpretation of backward model parameters can lead to wrong conclusions regarding the spatial or temporal origin of the neural signals of interest, since significant nonzero weights may also be observed at channels the activity of which is statistically independent of the brain process under study. As a remedy for the linear case, we propose a procedure for transforming backward models into forward models. This procedure enables the neurophysiological interpretation of the parameters of linear backward models. We hope that this work raises awareness for an often encountered problem and provides a theoretical basis for conducting better interpretable multivariate neuroimaging analyses. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

A Primer on Health Economic Evaluations in Thoracic Oncology.

PubMed

Whittington, Melanie D; Atherly, Adam J; Bocsi, Gregary T; Camidge, D Ross

2016-08-01

There is growing interest for economic evaluation in oncology to illustrate the value of multiple new diagnostic and therapeutic interventions. As these analyses have started to move from specialist publications into mainstream medical literature, the wider medical audience consuming this information may need additional education to evaluate it appropriately. Here we review standard practices in economic evaluation, illustrating the different methods with thoracic oncology examples where possible. When interpreting and conducting health economic studies, it is important to appraise the method, perspective, time horizon, modeling technique, discount rate, and sensitivity analysis. Guidance on how to do this is provided. To provide a method to evaluate this literature, a literature search was conducted in spring 2015 to identify economic evaluations published in the Journal of Thoracic Oncology. Articles were reviewed for their study design, and areas for improvement were noted. Suggested improvements include using more rigorous sensitivity analyses, adopting a standard approach to reporting results, and conducting complete economic evaluations. Researchers should design high-quality studies to ensure the validity of the results, and consumers of this research should interpret these studies critically on the basis of a full understanding of the methodologies used before considering any of the conclusions. As advancements occur on both the research and consumer sides, this literature can be further developed to promote the best use of resources for this field. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Hablamos Juntos (Together We Speak): Interpreters, Provider Communication, and Satisfaction with Care

PubMed Central

Morales, Leo S.

2010-01-01

BACKGROUND The Hablamos Juntos—Together We Speak (HJ)—national demonstration project targeted the improvement of language access for Spanish-speaking Latinos in areas with rapidly growing Latino populations. The objective of HJ was to improve doctor-patient communication by increasing access to and quality of interpreter services for Spanish-speaking patients. OBJECTIVE To investigate how access to interpreters for adult Spanish-speaking Latinos is associated with ratings of doctor/office staff communication and satisfaction with care. DESIGN Cross-sectional cohort study. PATIENTS A total of 1,590 Spanish-speaking Latino adults from eight sites across the United States who participated in the outpatient HJ evaluation. MEASUREMENTS We analyzed two multi-item measures of doctor communication (4 items) and office staff helpfulness (2 items), and one global item of satisfaction with care by interpreter use. We performed regression analyses to control for patient sociodemographic characteristics, survey year, and clustering at the site of care. RESULTS Ninety-five percent of participants were born outside the US, 81% were females, and survey response rates ranged from 45% to 85% across sites. In this cohort of Spanish-speaking patients, those who needed and always used interpreters reported better experiences with care than their counterparts who needed but had interpreters unavailable. Patients who always used an interpreter had better adjusted ratings of doctor communication [effect size (ES = 0.51)], office staff helpfulness (ES = 0.37), and satisfaction with care (ES = 0.37) than patients who needed but did not always use an interpreter. Patients who needed and always used interpreters also reported better experiences with care in all three domains measured [doctor communication (ES = 0.30), office staff helpfulness (ES = 0.21), and satisfaction with care (ES = 0.23)] than patients who did not need interpreters. CONCLUSIONS Among adult Spanish-speaking Latinos, interpreter use is independently associated with higher satisfaction with doctor communication, office staff helpfulness, and ambulatory care. Increased attention to the need for effective interpreter services is warranted in areas with rapidly growing Spanish-speaking populations. PMID:20703951

The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms

PubMed Central

Semenov, Alexander V; Elsas, Jan Dirk; Glandorf, Debora C M; Schilthuizen, Menno; Boer, Willem F

2013-01-01

Abstract To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on varied experimental designs. The recent EFSA guidance document for environmental risk assessment (2010) does not provide clear and structured suggestions that address the statistics of field trials on effects on NTO's. This review examines existing practices in GM plant field testing such as the way of randomization, replication, and pseudoreplication. Emphasis is placed on the importance of design features used for the field trials in which effects on NTO's are assessed. The importance of statistical power and the positive and negative aspects of various statistical models are discussed. Equivalence and difference testing are compared, and the importance of checking the distribution of experimental data is stressed to decide on the selection of the proper statistical model. While for continuous data (e.g., pH and temperature) classical statistical approaches – for example, analysis of variance (ANOVA) – are appropriate, for discontinuous data (counts) only generalized linear models (GLM) are shown to be efficient. There is no golden rule as to which statistical test is the most appropriate for any experimental situation. In particular, in experiments in which block designs are used and covariates play a role GLMs should be used. Generic advice is offered that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in this testing. The combination of decision trees and a checklist for field trials, which are provided, will help in the interpretation of the statistical analyses of field trials and to assess whether such analyses were correctly applied. We offer generic advice to risk assessors and applicants that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in field testing. PMID:24567836

The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms.

PubMed

Semenov, Alexander V; Elsas, Jan Dirk; Glandorf, Debora C M; Schilthuizen, Menno; Boer, Willem F

2013-08-01

To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on varied experimental designs. The recent EFSA guidance document for environmental risk assessment (2010) does not provide clear and structured suggestions that address the statistics of field trials on effects on NTO's. This review examines existing practices in GM plant field testing such as the way of randomization, replication, and pseudoreplication. Emphasis is placed on the importance of design features used for the field trials in which effects on NTO's are assessed. The importance of statistical power and the positive and negative aspects of various statistical models are discussed. Equivalence and difference testing are compared, and the importance of checking the distribution of experimental data is stressed to decide on the selection of the proper statistical model. While for continuous data (e.g., pH and temperature) classical statistical approaches - for example, analysis of variance (ANOVA) - are appropriate, for discontinuous data (counts) only generalized linear models (GLM) are shown to be efficient. There is no golden rule as to which statistical test is the most appropriate for any experimental situation. In particular, in experiments in which block designs are used and covariates play a role GLMs should be used. Generic advice is offered that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in this testing. The combination of decision trees and a checklist for field trials, which are provided, will help in the interpretation of the statistical analyses of field trials and to assess whether such analyses were correctly applied. We offer generic advice to risk assessors and applicants that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in field testing.

Perspectives of oncology nurses and oncologists regarding barriers to working with patients from a minority background: Systemic issues and working with interpreters.

PubMed

Watts, K J; Meiser, B; Zilliacus, E; Kaur, R; Taouk, M; Girgis, A; Butow, P; Kissane, D W; Hale, S; Perry, A; Aranda, S K; Goldstein, D

2018-03-01

This study aimed to ascertain the systemic barriers encountered by oncology health professionals (HPs) working with patients from ethnic minorities to guide the development of a communication skills training programme. Twelve medical and five radiation oncologists and 21 oncology nurses were invited to participate in this qualitative study. Participants were interviewed individually or in a focus group about their experiences working with people from minority backgrounds. All interviews were transcribed verbatim and analysed thematically. HPs encountered language and communication barriers in their interactions with patients and their families, which were perceived to impact negatively on the quality and amount of information and support provided. There was a shortage of, and poor processes for engaging, interpreters and some HPs were concerned about the accuracy of interpretation. HPs expressed a need for training in cultural awareness and communication skills with a preference for face-to-face delivery. A lack of funding, a culture of "learning on the job", and time constraints were systemic barriers to training. Oncologists and oncology nurses encounter complex challenges in clinical interactions with minority patients and their families, including difficulties working with interpreters. Formal training programmes targeted to the development of culturally competent communication skills are required. © 2017 John Wiley & Sons Ltd.

Comparative facies formation in selected coal beds of the Powder River Basin

USGS Publications Warehouse

Stanton, R.W.; Moore, Timothy A.; Warwick, Peter D.; Crowley, S.S.; Flores, Romeo M.; Flores, Romeo M.; Warwick, Peter D.; Moore, Timothy A.; Glass, Gary; Smith, Archie; Nichols, Douglas J.; Wolfe, Jack A.; Stanton, Ronald W.; Weaver, Jean

1989-01-01

Petrologic studies of thick coal beds [Warwick, 1985; Moore, 1986; Moore and others, 1986; Moore and others, 1987; Warwick and Stanton, in press], which build on sedimentological interpretations [Flores, this volume] of associated units, provide data to interpret and contrast the varieties of peat formation in the Powder River Basin. Detailed analyses of the composition of coal beds lead to more complete interpretations regarding the depositional environment on a regional and local scale. Our efforts in the Powder River Basin [areas A-D in fig. 1 of Flores, this volume] have resulted in a series of site-specific studies that interpret the types of peat formation from the arrangement of different facies which comprise the coal beds and from the spatial form of the coal beds.Our approach was to use a combination of megascopic criteria for facies sampling, and where only core was available, to analyze many interval samples to discriminate facies by their maceral composition. Coal beds in the Powder River Basin are composed of laterally continuous, compositional subunits of the bed (facies) that can be discerned most easily in weathered highwall exposures, less readily in fresh highwalls, and very poorly in fresh-cut core surfaces. In general, very low ash ( 

Cutting Corners: Provider Perceptions of Interpretation Services and Factors Related to Use of an Ad Hoc Interpreter.

PubMed

Mayo, Rachel; Parker, Veronica G; Sherrill, Windsor W; Coltman, Kinneil; Hudson, Matthew F; Nichols, Christina M; Yates, Adam M; Pribonic, Anne Paige

2016-06-01

This study assessed health providers' perceptions of factors related to professional interpretation services and the association between these factors and the potential use of ad hoc interpreters. Data were collected from a convenience sample of 150 health services providers at a large, regional health system in South Carolina. Providers rated "ability to communicate effectively during a clinical encounter" as paramount regarding the use of interpretation services. The most important factors related to the likely use of ad hoc interpreters (cutting corners) included locating a qualified interpreter, having to wait for a qualified interpreter, and technical difficulties regarding phone and video technology. Health care organizations may benefit from increasing staff awareness about patient safety and legal and regulatory risks involved with the use of ad hoc interpreters. © The Author(s) 2016.

Retroreflective Background Oriented Schlieren Imaging Results from the NASA Plume/Shock Interaction Test

NASA Technical Reports Server (NTRS)

Smith, Nathanial T.; Durston, Donald A.; Heineck, James T.

2017-01-01

In support of NASA's Commercial Supersonics Technology (CST) project, a test was conducted in the 9-by-7 ft. supersonic section of the NASA Ames Unitary Plan Wind Tunnel (UPWT). The tests were designed to study the interaction of shocks with a supersonic jet characteristic of those that may occur on a commercial supersonic aircraft. Multiple shock generating geometries were tested to examine the interaction dynamics as they pertain to sonic boom mitigation. An integral part of the analyses of these interactions are the interpretation of the data generated from the retroreflective Background Oriented Schlieren (RBOS) imaging technique employed for this test. The regularization- based optical flow methodology used to generate these data is described. Sample results are compared to those using normalized cross-correlation. The reduced noise, additional feature detail, and fewer false artifacts provided by the optical flow technique produced clearer time-averaged images, allowing for better interpretation of the underlying flow phenomena. These images, coupled with pressure signatures in the near field, are used to provide an overview of the detailed interaction flowfields.

Numerical model for healthy and injured ankle ligaments.

PubMed

Forestiero, Antonella; Carniel, Emanuele Luigi; Fontanella, Chiara Giulia; Natali, Arturo Nicola

2017-06-01

The aim of this work is to provide a computational tool for the investigation of ankle mechanics under different loading conditions. The attention is focused on the biomechanical role of ankle ligaments that are fundamental for joints stability. A finite element model of the human foot is developed starting from Computed Tomography and Magnetic Resonance Imaging, using particular attention to the definition of ankle ligaments. A refined fiber-reinforced visco-hyperelastic constitutive model is assumed to characterize the mechanical response of ligaments. Numerical analyses that interpret anterior drawer and the talar tilt tests reported in literature are performed. The numerical results are in agreement with the range of values obtained by experimental tests confirming the accuracy of the procedure adopted. The increase of the ankle range of motion after some ligaments rupture is also evaluated, leading to the capability of the numerical models to interpret the damage conditions. The developed computational model provides a tool for the investigation of foot and ankle functionality in terms of stress-strain of the tissues and in terms of ankle motion, considering different types of damage to ankle ligaments.

VisRseq: R-based visual framework for analysis of sequencing data

PubMed Central

2015-01-01

Background Several tools have been developed to enable biologists to perform initial browsing and exploration of sequencing data. However the computational tool set for further analyses often requires significant computational expertise to use and many of the biologists with the knowledge needed to interpret these data must rely on programming experts. Results We present VisRseq, a framework for analysis of sequencing datasets that provides a computationally rich and accessible framework for integrative and interactive analyses without requiring programming expertise. We achieve this aim by providing R apps, which offer a semi-auto generated and unified graphical user interface for computational packages in R and repositories such as Bioconductor. To address the interactivity limitation inherent in R libraries, our framework includes several native apps that provide exploration and brushing operations as well as an integrated genome browser. The apps can be chained together to create more powerful analysis workflows. Conclusions To validate the usability of VisRseq for analysis of sequencing data, we present two case studies performed by our collaborators and report their workflow and insights. PMID:26328469

VisRseq: R-based visual framework for analysis of sequencing data.

PubMed

Younesy, Hamid; Möller, Torsten; Lorincz, Matthew C; Karimi, Mohammad M; Jones, Steven J M

2015-01-01

Several tools have been developed to enable biologists to perform initial browsing and exploration of sequencing data. However the computational tool set for further analyses often requires significant computational expertise to use and many of the biologists with the knowledge needed to interpret these data must rely on programming experts. We present VisRseq, a framework for analysis of sequencing datasets that provides a computationally rich and accessible framework for integrative and interactive analyses without requiring programming expertise. We achieve this aim by providing R apps, which offer a semi-auto generated and unified graphical user interface for computational packages in R and repositories such as Bioconductor. To address the interactivity limitation inherent in R libraries, our framework includes several native apps that provide exploration and brushing operations as well as an integrated genome browser. The apps can be chained together to create more powerful analysis workflows. To validate the usability of VisRseq for analysis of sequencing data, we present two case studies performed by our collaborators and report their workflow and insights.

The relationship between multilevel models and non-parametric multilevel mixture models: Discrete approximation of intraclass correlation, random coefficient distributions, and residual heteroscedasticity.

PubMed

Rights, Jason D; Sterba, Sonya K

2016-11-01

Multilevel data structures are common in the social sciences. Often, such nested data are analysed with multilevel models (MLMs) in which heterogeneity between clusters is modelled by continuously distributed random intercepts and/or slopes. Alternatively, the non-parametric multilevel regression mixture model (NPMM) can accommodate the same nested data structures through discrete latent class variation. The purpose of this article is to delineate analytic relationships between NPMM and MLM parameters that are useful for understanding the indirect interpretation of the NPMM as a non-parametric approximation of the MLM, with relaxed distributional assumptions. We define how seven standard and non-standard MLM specifications can be indirectly approximated by particular NPMM specifications. We provide formulas showing how the NPMM can serve as an approximation of the MLM in terms of intraclass correlation, random coefficient means and (co)variances, heteroscedasticity of residuals at level 1, and heteroscedasticity of residuals at level 2. Further, we discuss how these relationships can be useful in practice. The specific relationships are illustrated with simulated graphical demonstrations, and direct and indirect interpretations of NPMM classes are contrasted. We provide an R function to aid in implementing and visualizing an indirect interpretation of NPMM classes. An empirical example is presented and future directions are discussed. © 2016 The British Psychological Society.

Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained.

PubMed

Barber, Chris; Cayley, Alex; Hanser, Thierry; Harding, Alex; Heghes, Crina; Vessey, Jonathan D; Werner, Stephane; Weiner, Sandy K; Wichard, Joerg; Giddings, Amanda; Glowienke, Susanne; Parenty, Alexis; Brigo, Alessandro; Spirkl, Hans-Peter; Amberg, Alexander; Kemper, Ray; Greene, Nigel

2016-04-01

The relative wealth of bacterial mutagenicity data available in the public literature means that in silico quantitative/qualitative structure activity relationship (QSAR) systems can readily be built for this endpoint. A good means of evaluating the performance of such systems is to use private unpublished data sets, which generally represent a more distinct chemical space than publicly available test sets and, as a result, provide a greater challenge to the model. However, raw performance metrics should not be the only factor considered when judging this type of software since expert interpretation of the results obtained may allow for further improvements in predictivity. Enough information should be provided by a QSAR to allow the user to make general, scientifically-based arguments in order to assess and overrule predictions when necessary. With all this in mind, we sought to validate the performance of the statistics-based in vitro bacterial mutagenicity prediction system Sarah Nexus (version 1.1) against private test data sets supplied by nine different pharmaceutical companies. The results of these evaluations were then analysed in order to identify findings presented by the model which would be useful for the user to take into consideration when interpreting the results and making their final decision about the mutagenic potential of a given compound. Copyright © 2015 Elsevier Inc. All rights reserved.

Australian Curriculum Linked Lessons: Statistics

ERIC Educational Resources Information Center

Day, Lorraine

2014-01-01

Students recognise and analyse data and draw inferences. They represent, summarise and interpret data and undertake purposeful investigations involving the collection and interpretation of data… They develop an increasingly sophisticated ability to critically evaluate chance and data concepts and make reasoned judgments and decisions, as well as…

Exploring the potential of analysing visual search behaviour data using FROC (free-response receiver operating characteristic) method: an initial study

NASA Astrophysics Data System (ADS)

Dong, Leng; Chen, Yan; Dias, Sarah; Stone, William; Dias, Joseph; Rout, John; Gale, Alastair G.

2017-03-01

Visual search techniques and FROC analysis have been widely used in radiology to understand medical image perceptual behaviour and diagnostic performance. The potential of exploiting the advantages of both methodologies is of great interest to medical researchers. In this study, eye tracking data of eight dental practitioners was investigated. The visual search measures and their analyses are considered here. Each participant interpreted 20 dental radiographs which were chosen by an expert dental radiologist. Various eye movement measurements were obtained based on image area of interest (AOI) information. FROC analysis was then carried out by using these eye movement measurements as a direct input source. The performance of FROC methods using different input parameters was tested. The results showed that there were significant differences in FROC measures, based on eye movement data, between groups with different experience levels. Namely, the area under the curve (AUC) score evidenced higher values for experienced group for the measurements of fixation and dwell time. Also, positive correlations were found for AUC scores between the eye movement data conducted FROC and rating based FROC. FROC analysis using eye movement measurements as input variables can act as a potential performance indicator to deliver assessment in medical imaging interpretation and assess training procedures. Visual search data analyses lead to new ways of combining eye movement data and FROC methods to provide an alternative dimension to assess performance and visual search behaviour in the area of medical imaging perceptual tasks.

Qualitatively modelling and analysing genetic regulatory networks: a Petri net approach.

PubMed

Steggles, L Jason; Banks, Richard; Shaw, Oliver; Wipat, Anil

2007-02-01

New developments in post-genomic technology now provide researchers with the data necessary to study regulatory processes in a holistic fashion at multiple levels of biological organization. One of the major challenges for the biologist is to integrate and interpret these vast data resources to gain a greater understanding of the structure and function of the molecular processes that mediate adaptive and cell cycle driven changes in gene expression. In order to achieve this biologists require new tools and techniques to allow pathway related data to be modelled and analysed as network structures, providing valuable insights which can then be validated and investigated in the laboratory. We propose a new technique for constructing and analysing qualitative models of genetic regulatory networks based on the Petri net formalism. We take as our starting point the Boolean network approach of treating genes as binary switches and develop a new Petri net model which uses logic minimization to automate the construction of compact qualitative models. Our approach addresses the shortcomings of Boolean networks by providing access to the wide range of existing Petri net analysis techniques and by using non-determinism to cope with incomplete and inconsistent data. The ideas we present are illustrated by a case study in which the genetic regulatory network controlling sporulation in the bacterium Bacillus subtilis is modelled and analysed. The Petri net model construction tool and the data files for the B. subtilis sporulation case study are available at http://bioinf.ncl.ac.uk/gnapn.

Protein molecular data from ancient (>1 million years old) fossil material: pitfalls, possibilities and grand challenges.

PubMed

Schweitzer, Mary Higby; Schroeter, Elena R; Goshe, Michael B

2014-07-15

Advances in resolution and sensitivity of analytical techniques have provided novel applications, including the analyses of fossil material. However, the recovery of original proteinaceous components from very old fossil samples (defined as >1 million years (1 Ma) from previously named limits in the literature) is far from trivial. Here, we discuss the challenges to recovery of proteinaceous components from fossils, and the need for new sample preparation techniques, analytical methods, and bioinformatics to optimize and fully utilize the great potential of information locked in the fossil record. We present evidence for survival of original components across geological time, and discuss the potential benefits of recovery, analyses, and interpretation of fossil materials older than 1 Ma, both within and outside of the fields of evolutionary biology.

Contexts for change in alpine tundra

USGS Publications Warehouse

Malanson, George P.; Rose, Jonathan P.; Schroeder, P. Jason; Fagre, Daniel B.

2011-01-01

Because alpine tundra is responding to climate change, a need exists to understand the meaning of observed changes. To provide context for such interpretation, the relevance of niche and neutral theories of biogeography and the continuum and classification approaches to biogeographic description are assessed. Two extensive studies of alpine tundra, from the Indian Peaks area, Colorado and Glacier National Park, Montana, are combined. The data are ordinated to describe relations. The pattern that emerges is one of a continuum of vegetation, but with the distinctions one might expect from distant sites. The relationships of the similarity of vegetation on all possible pairs of sites to the environmental differences and geographic distances are analyzed using Mantel correlations. Because distance and environmental differences in climate between the two sites are correlated, partial correlations are weak but still significant. More advanced analyses are suggested for this environment prior to interpretation of monitoring efforts such as GLORIA.

Earth Science Studies in Support of Public Policy Development and Land Stewardship - Headwaters Province, Idaho and Montana

USGS Publications Warehouse

U.S. Geological Survey Headwaters Province Project Team Edited by Lund, Karen

2007-01-01

The USGS Headwaters Province project in western Montana and northern and central Idaho was designed to provide geoscience data and interpretations to Federal Land Management Agencies and to respond to specific concerns of USDA Forest Service Regions 1 and 4. The project has emphasized development of digital geoscience data, GIS analyses, topical studies, and new geologic interpretations. Studies were designed to more completely map lithologic units and determine controls of deformation, magmatism, and mineralizing processes. Topical studies of geologic basement control on these processes include study of regional metallogenic patterns and their relation to the composition and architecture of underlying, unexposed basement; timing of igneous and hydrothermal systems, to identify regionally important metallogenic magmatism; and the geologic setting of Proterozoic strata, to better understand how their sedimentary basins developed and to define the origin of sediment-hosted mineral deposits. Interrelated products of the project are at complementary scales.

What exactly do numbers mean?

PubMed Central

Huang, Yi Ting; Spelke, Elizabeth; Snedeker, Jesse

2014-01-01

Number words are generally used to refer to the exact cardinal value of a set, but cognitive scientists disagree about their meanings. Although most psychological analyses presuppose that numbers have exact semantics (two means EXACTLY TWO), many linguistic accounts propose that numbers have lower-bounded semantics (AT LEAST TWO), and that speakers restrict their reference through a pragmatic inference (scalar implicature). We address this debate through studies of children who are in the process of acquiring the meanings of numbers. Adults and 2- and 3-year-olds were tested in a novel paradigm that teases apart semantic and pragmatic aspects of interpretation (the covered box task). Our findings establish that when scalar implicatures are cancelled in the critical trials of this task, both adults and children consistently give exact interpretations for number words. These results, in concert with recent work on real-time processing, provide the first unambiguous evidence that number words have exact semantics. PMID:25285053

Geologic mapping of the Bauru Group in Sao Paulo state by LANDSAT images. [Brazil

NASA Technical Reports Server (NTRS)

Parada, N. D. J. (Principal Investigator); Godoy, A. M.

1983-01-01

The occurrence of the Bauru Group in Sao Paulo State was studied, with emphasis on the western plateau. Regional geological mapping was carried out on a 1:250.000 scale with the help of MSS/LANDSAT images. The visual interpretation of images consisted basically of identifying different spectral characteristics of the geological units using channels 5 and 7. Complementary studies were made for treatment of data with an Interative Image (I-100) analyser in order to facilitate the extraction of information, particularly for areas where visual interpretation proved to be difficult. Regional characteristics provided by MSS/LANDSAT images, coupled with lithostratigraphic studies carried out in the areas of occurrence of Bauru Group sediments, enabled the homogenization of criteria for the subdivision of this group. A spatial distribution of the mapped units was obtained for the entire State of Sao Paulo and results were correlated with proposed stratigraphic divisions.

Markov Chain Monte Carlo: an introduction for epidemiologists

PubMed Central

Hamra, Ghassan; MacLehose, Richard; Richardson, David

2013-01-01

Markov Chain Monte Carlo (MCMC) methods are increasingly popular among epidemiologists. The reason for this may in part be that MCMC offers an appealing approach to handling some difficult types of analyses. Additionally, MCMC methods are those most commonly used for Bayesian analysis. However, epidemiologists are still largely unfamiliar with MCMC. They may lack familiarity either with he implementation of MCMC or with interpretation of the resultant output. As with tutorials outlining the calculus behind maximum likelihood in previous decades, a simple description of the machinery of MCMC is needed. We provide an introduction to conducting analyses with MCMC, and show that, given the same data and under certain model specifications, the results of an MCMC simulation match those of methods based on standard maximum-likelihood estimation (MLE). In addition, we highlight examples of instances in which MCMC approaches to data analysis provide a clear advantage over MLE. We hope that this brief tutorial will encourage epidemiologists to consider MCMC approaches as part of their analytic tool-kit. PMID:23569196

Analyses of historical and projected climates to support climate adaptation in the northern Rocky Mountains: Chapter 4

USGS Publications Warehouse

Gross, John E.; Tercek, Michael; Guay, Kevin; Chang, Tony; Talbert, Marian; Rodman, Ann; Thoma, David; Jantz, Patrick; Morisette, Jeffrey T.

2016-01-01

Most of the western United States is experiencing the effects of rapid and directional climate change (Garfin et al. 2013). These effects, along with forecasts of profound changes in the future, provide strong motivation for resource managers to learn about and prepare for future changes. Climate adaptation plans are based on an understanding of historic climate variation and their effects on ecosystems and on forecasts of future climate trends. Frameworks for climate adaptation thus universally identify the importance of a summary of historical, current, and projected climates (Glick, Stein, and Edelson 2011; Cross et al. 2013; Stein et al. 2014). Trends in physical climate variables are usually the basis for evaluating the exposure component in vulnerability assessments. Thus, this chapter focuses on step 2 of the Climate-Smart Conservation framework (chap. 2): vulnerability assessment. We present analyses of historical and current observations of temperature, precipitation, and other key climate measurements to provide context and a baseline for interpreting the ecological impacts of projected climate changes.

Phylogeny of seed plants based on all three genomic compartments: extant gymnosperms are monophyletic and Gnetales' closest relatives are conifers.

PubMed

Bowe, L M; Coat, G; dePamphilis, C W

2000-04-11

Efforts to resolve Darwin's "abominable mystery"-the origin of angiosperms-have led to the conclusion that Gnetales and various fossil groups are sister to angiosperms, forming the "anthophytes." Morphological homologies, however, are difficult to interpret, and molecular data have not provided clear resolution of relationships among major groups of seed plants. We introduce two sequence data sets from slowly evolving mitochondrial genes, cox1 and atpA, which unambiguously reject the anthophyte hypothesis, favoring instead a close relationship between Gnetales and conifers. Parsimony- and likelihood-based analyses of plastid rbcL and nuclear 18S rDNA alone and with cox1 and atpA also strongly support a gnetophyte-conifer grouping. Surprisingly, three of four genes (all but nuclear rDNA) and combined three-genome analyses also suggest or strongly support Gnetales as derived conifers, sister to Pinaceae. Analyses with outgroups screened to avoid long branches consistently identify all gymnosperms as a monophyletic sister group to angiosperms. Combined three- and four-gene rooted analyses resolve the branching order for the remaining major groups-cycads separate from other gymnosperms first, followed by Ginkgo and then (Gnetales + Pinaceae) sister to a monophyletic group with all other conifer families. The molecular phylogeny strongly conflicts with current interpretations of seed plant morphology, and implies that many similarities between gnetophytes and angiosperms, such as "flower-like" reproductive structures and double fertilization, were independently derived, whereas other characters could emerge as synapomorphies for an expanded conifer group including Gnetales. An initial angiosperm-gymnosperm split implies a long stem lineage preceding the explosive Mesozoic radiation of flowering plants and suggests that angiosperm origins and homologies should be sought among extinct seed plant groups.

Cross-Sectional Analysis of Longitudinal Mediation Processes.

PubMed

O'Laughlin, Kristine D; Martin, Monica J; Ferrer, Emilio

2018-01-01

Statistical mediation analysis can help to identify and explain the mechanisms behind psychological processes. Examining a set of variables for mediation effects is a ubiquitous process in the social sciences literature; however, despite evidence suggesting that cross-sectional data can misrepresent the mediation of longitudinal processes, cross-sectional analyses continue to be used in this manner. Alternative longitudinal mediation models, including those rooted in a structural equation modeling framework (cross-lagged panel, latent growth curve, and latent difference score models) are currently available and may provide a better representation of mediation processes for longitudinal data. The purpose of this paper is twofold: first, we provide a comparison of cross-sectional and longitudinal mediation models; second, we advocate using models to evaluate mediation effects that capture the temporal sequence of the process under study. Two separate empirical examples are presented to illustrate differences in the conclusions drawn from cross-sectional and longitudinal mediation analyses. Findings from these examples yielded substantial differences in interpretations between the cross-sectional and longitudinal mediation models considered here. Based on these observations, researchers should use caution when attempting to use cross-sectional data in place of longitudinal data for mediation analyses.

Nearby Type Ia Supernova Follow-up at the Thacher Observatory

NASA Astrophysics Data System (ADS)

Swift, Jonathan; O'Neill, Katie; Kilpatrick, Charles; Foley, Ryan

2018-06-01

Type Ia supernovae (SN Ia) provide an effective way to study the expansion of the universe through analyses of their photometry and spectroscopy. The interpretation of high-redshift SN Ia is dependent on accurate characterization of nearby, low-redshift targets. To help build up samples of nearby SN Ia, the Thacher Observatory has begun a photometric follow-up program in 4 photometric bands. Here we present the observations and analysis of multi-band photometry for several recent supernovae as well as FLOYDS spectra from the Las Cumbres Observatory.

Weather analysis and interpretation procedures developed for the US/Canada wheat and barley exploratory experiment

NASA Technical Reports Server (NTRS)

Trenchard, M. H. (Principal Investigator)

1980-01-01

Procedures and techniques for providing analyses of meteorological conditions at segments during the growing season were developed for the U.S./Canada Wheat and Barley Exploratory Experiment. The main product and analysis tool is the segment-level climagraph which depicts temporally meteorological variables for the current year compared with climatological normals. The variable values for the segment are estimates derived through objective analysis of values obtained at first-order station in the region. The procedures and products documented represent a baseline for future Foreign Commodity Production Forecasting experiments.

Chemical Mixing Model and K-Th-Ti Systematics and HED Meteorites for the Dawn Mission

NASA Technical Reports Server (NTRS)

Usui, T.; McSween, H. Y., Jr.; Mittlefehldt, D. W.; Prettyman, T. H.

2009-01-01

The Dawn mission will explore 4 Vesta, a large differentiated asteroid believed to be the parent body of the howardite, eucrite and diogenite (HED) meteorite suite. The Dawn spacecraft carries a gamma-ray and neutron detector (GRaND), which will measure the abundances of selected elements on the surface of Vesta. This study provides ways to leverage the large geochemical database on HED meteorites as a tool for interpreting chemical analyses by GRaND of mapped units on the surface of Vesta.

Groundwater and streamflow information program Kansas Cooperative Water Science since 1895

USGS Publications Warehouse

Painter, Colin C.; Kramer, Ariele R.; Kelly, Brian P.

2017-05-10

The U.S. Geological Survey, in cooperation with State, local, and other Federal agencies, operates a network of streamgages throughout the State of Kansas. Data provided by this network are used to forecast floods, operate reservoirs, develop water policy, administer regulation of water, and perform interpretive analyses of streamflow. This data collection and analysis effort has been sustained since 1895 through cooperative matching fund programs that allow the USGS to work with cooperative agencies to solve groundwater and surface water challenges that affect citizens locally and throughout the Nation.  

Spectroscopic diagnostics of solar flares

NASA Astrophysics Data System (ADS)

Bely-Dubau, F.; Dubau, J.; Faucher, P.; Loulergue, M.; Steenman-Clarke, L.

Observations made with the X-ray polychromator (XRP) on board the Solar Maximum Mission satellite were analyzed. Data from the bent crystal spectrometer portion of the XRP experiment, in the spectral domain 1 to 3 A, with high spectral and temporal resolution, were used. Results for the spectrum analysis of iron are given. The possibility of polarization effects is considered. Although it is demonstrated that hyperfine analyses of a given spectrum are obtainable, provided calculations include large quantities of high precision atomic data, the interpretation is limited by the hypothesis of homogeneity of the emitting plasma.

Qualitative Data Analysis and Interpretation in Counseling Psychology: Strategies for Best Practices

ERIC Educational Resources Information Center

Yeh, Christine J.; Inman, Arpana G.

2007-01-01

This article presents an overview of various strategies and methods of engaging in qualitative data interpretations and analyses in counseling psychology. The authors explore the themes of self, culture, collaboration, circularity, trustworthiness, and evidence deconstruction from multiple qualitative methodologies. Commonalities and differences…

Video medical interpretation over 3G cellular networks: a feasibility study.

PubMed

Locatis, Craig; Williamson, Deborah; Sterrett, James; Detzler, Isabel; Ackerman, Michael

2011-12-01

To test the feasibility of using cell phone technology to provide video medical interpretation services at a distance. Alternative cell phone services were researched and videoconferencing technologies were tried out to identify video products and telecommunication services needed to meet video medical interpretation requirements. The video and telecommunication technologies were tried out in a pharmacy setting and compared with use of the telephone. Outcomes were similar to findings in previous research involving video medical interpretation with higher bandwidth and video quality. Patients appreciated the interpretation service no matter how it is provided, while health providers and interpreters preferred video. It is possible to provide video medical interpretation services via cellular communication using lower bandwidth videoconferencing technology that provides sufficient quality, at least in pharmacy settings. However, a number of issues need to be addressed to ensure quality of service.

Factors That Influence the Receipt of Eye Care

PubMed Central

Alexander, Robert L.; Miller, Nancy A.; Cotch, Mary Frances; Janiszewski, Rosemary

2010-01-01

Objectives To better understand what factors influence the receipt of eye care so that screening and education programs can be designed to promote early detection and treatment. Methods Twenty focus groups were conducted. Analyses entailed debriefing sessions, coding, and interpreting transcribed data. Results Attitudes about eyesight and eye exams influence the receipt of preventive eye care. Limited knowledge about certain eye diseases and conditions was reported. Participants stated that their primary care providers did not communicate information with them about eyesight nor did they conduct basic eye screenings. Conclusions Improving provider-patient interactions and developing public health messages about eye diseases and preventive eye care can facilitate increased use of appropriate eye care services. PMID:18241139

Abstract Interpreters for Free

NASA Astrophysics Data System (ADS)

Might, Matthew

In small-step abstract interpretations, the concrete and abstract semantics bear an uncanny resemblance. In this work, we present an analysis-design methodology that both explains and exploits that resemblance. Specifically, we present a two-step method to convert a small-step concrete semantics into a family of sound, computable abstract interpretations. The first step re-factors the concrete state-space to eliminate recursive structure; this refactoring of the state-space simultaneously determines a store-passing-style transformation on the underlying concrete semantics. The second step uses inference rules to generate an abstract state-space and a Galois connection simultaneously. The Galois connection allows the calculation of the "optimal" abstract interpretation. The two-step process is unambiguous, but nondeterministic: at each step, analysis designers face choices. Some of these choices ultimately influence properties such as flow-, field- and context-sensitivity. Thus, under the method, we can give the emergence of these properties a graph-theoretic characterization. To illustrate the method, we systematically abstract the continuation-passing style lambda calculus to arrive at two distinct families of analyses. The first is the well-known k-CFA family of analyses. The second consists of novel "environment-centric" abstract interpretations, none of which appear in the literature on static analysis of higher-order programs.

Interpreting the results of a modified gravity model: examining access to primary health care physicians in five Canadian provinces and territories.

PubMed

Crooks, Valorie A; Schuurman, Nadine

2012-08-01

Primary health care (PHC) encompasses an array of health and social services that focus on preventative, diagnostic, and basic care measures to maintain wellbeing and address illnesses. In Canada, PHC involves the provision of first-contact health care services by providers such as family physicians and general practitioners - collectively referred as PHC physicians here. Ensuring access is a key requirement of effective PHC delivery. This is because having access to PHC has been shown to positively impact a number of health outcomes. We build on recent innovations in measuring potential spatial access to PHC physicians using geographic information systems (GIS) by running and then interpreting the findings of a modified gravity model. Elsewhere we have introduced the protocol for this model. In this article we run it for five selected Canadian provinces and territories. Our objectives are to present the results of the modified gravity model in order to: (1) understand how potential spatial access to PHC physicians can be interpreted in these Canadian jurisdictions, and (2) provide guidance regarding how findings of the modified gravity model should be interpreted in other analyses. Regarding the first objective, two distinct spatial patterns emerge regarding potential spatial access to PHC physicians in the five selected Canadian provinces: (1) a clear north-south pattern, where southern areas have greater potential spatial access than northern areas; and (2) while gradients of potential spatial access exist in and around urban areas, access outside of densely-to-moderately populated areas is fairly binary. Regarding the second objective, we identify three principles that others can use to interpret the findings of the modified gravity model when used in other research contexts. Future applications of the modified gravity model are needed in order to refine the recommendations we provide on interpreting its results. It is important that studies are undertaken that can help administrators, policy-makers, researchers, and others with characterizing the state of access to PHC, including potential spatial access. We encourage further research to be done using GIS in order to offer new, spatial perspectives on issues of access to health services given the increased recognition that the place-based nature of health services can benefit from the use of the capabilities of GIS to enhance the role that visualization plays in decision-making.

Interpreting the results of a modified gravity model: examining access to primary health care physicians in five Canadian provinces and territories

PubMed Central

2012-01-01

Background Primary health care (PHC) encompasses an array of health and social services that focus on preventative, diagnostic, and basic care measures to maintain wellbeing and address illnesses. In Canada, PHC involves the provision of first-contact health care services by providers such as family physicians and general practitioners – collectively referred as PHC physicians here. Ensuring access is a key requirement of effective PHC delivery. This is because having access to PHC has been shown to positively impact a number of health outcomes. Methods We build on recent innovations in measuring potential spatial access to PHC physicians using geographic information systems (GIS) by running and then interpreting the findings of a modified gravity model. Elsewhere we have introduced the protocol for this model. In this article we run it for five selected Canadian provinces and territories. Our objectives are to present the results of the modified gravity model in order to: (1) understand how potential spatial access to PHC physicians can be interpreted in these Canadian jurisdictions, and (2) provide guidance regarding how findings of the modified gravity model should be interpreted in other analyses. Results Regarding the first objective, two distinct spatial patterns emerge regarding potential spatial access to PHC physicians in the five selected Canadian provinces: (1) a clear north–south pattern, where southern areas have greater potential spatial access than northern areas; and (2) while gradients of potential spatial access exist in and around urban areas, access outside of densely-to-moderately populated areas is fairly binary. Regarding the second objective, we identify three principles that others can use to interpret the findings of the modified gravity model when used in other research contexts. Conclusions Future applications of the modified gravity model are needed in order to refine the recommendations we provide on interpreting its results. It is important that studies are undertaken that can help administrators, policy-makers, researchers, and others with characterizing the state of access to PHC, including potential spatial access. We encourage further research to be done using GIS in order to offer new, spatial perspectives on issues of access to health services given the increased recognition that the place-based nature of health services can benefit from the use of the capabilities of GIS to enhance the role that visualization plays in decision-making. PMID:22852816

A multidimensional approach to assessing intervention fidelity in a process evaluation of audit and feedback interventions to reduce unnecessary blood transfusions: a study protocol.

PubMed

Lorencatto, Fabiana; Gould, Natalie J; McIntyre, Stephen A; During, Camilla; Bird, Jon; Walwyn, Rebecca; Cicero, Robert; Glidewell, Liz; Hartley, Suzanne; Stanworth, Simon J; Foy, Robbie; Grimshaw, Jeremy M; Michie, Susan; Francis, Jill J

2016-12-12

In England, NHS Blood and Transplant conducts national audits of transfusion and provides feedback to hospitals to promote evidence-based practice. Audits demonstrate 20% of transfusions fall outside guidelines. The AFFINITIE programme (Development & Evaluation of Audit and Feedback INterventions to Increase evidence-based Transfusion practIcE) involves two linked, 2×2 factorial, cluster-randomised trials, each evaluating two theoretically-enhanced audit and feedback interventions to reduce unnecessary blood transfusions in UK hospitals. The first intervention concerns the content/format of feedback reports. The second aims to support hospital transfusion staff to plan their response to feedback and includes a web-based toolkit and telephone support. Interpretation of trials is enhanced by comprehensively assessing intervention fidelity. However, reviews demonstrate fidelity evaluations are often limited, typically only assessing whether interventions were delivered as intended. This protocol presents methods for assessing fidelity across five dimensions proposed by the Behaviour Change Consortium fidelity framework, including intervention designer-, provider- and recipient-levels. (1) Design: Intervention content will be specified in intervention manuals in terms of component behaviour change techniques (BCTs). Treatment differentiation will be examined by comparing BCTs across intervention/standard practice, noting the proportion of unique/convergent BCTs. (2) Training: draft feedback reports and audio-recorded role-play telephone support scenarios will be content analysed to assess intervention providers' competence to deliver manual-specified BCTs. (3) Delivery: intervention materials (feedback reports, toolkit) and audio-recorded telephone support session transcripts will be content analysed to assess actual delivery of manual-specified BCTs during the intervention period. (4) Receipt and (5) enactment: questionnaires, semi-structured interviews based on the Theoretical Domains Framework, and objective web-analytics data (report downloads, toolkit usage patterns) will be analysed to assess hospital transfusion staff exposure to, understanding and enactment of the interventions, and to identify contextual barriers/enablers to implementation. Associations between observed fidelity and trial outcomes (% unnecessary transfusions) will be examined using mediation analyses. If the interventions have acceptable fidelity, then results of the AFFINITIE trials can be attributed to effectiveness, or lack of effectiveness, of the interventions. Hence, this comprehensive assessment of fidelity will be used to interpret trial findings. These methods may inform fidelity assessments in future trials. ISRCTN 15490813 . Registered 11/03/2015.

Hair analyses: worthless for vitamins, limited for minerals.

PubMed

Hambidge, K M

1982-11-01

Despite many major and minor problems with interpretation of analytical data, chemical analyses of human hair have some potential value. Extensive research will be necessary to define this value, including correlation of hair concentrations of specific elements with those in other tissues and metabolic pools and definition of normal physiological concentration ranges. Many factors that may compromise the correct interpretation of analytical data require detailed evaluation for each specific element. Meanwhile, hair analyses are of some value in the comparison of different populations and, for example, in public health community surveys of environmental exposure to heavy metals. On an individual basis, their established usefulness is much more restricted and the limitations are especially notable for evaluation of mineral nutritional status. There is a wide gulf between the limited and mainly tentative scientific justification for their use on an individual basis and the current exploitation of multielement chemical analyses of human hair.

Individuality in harpsichord performance: disentangling performer- and piece-specific influences on interpretive choices

PubMed Central

Gingras, Bruno; Asselin, Pierre-Yves; McAdams, Stephen

2013-01-01

Although a growing body of research has examined issues related to individuality in music performance, few studies have attempted to quantify markers of individuality that transcend pieces and musical styles. This study aims to identify such meta-markers by discriminating between influences linked to specific pieces or interpretive goals and performer-specific playing styles, using two complementary statistical approaches: linear mixed models (LMMs) to estimate fixed (piece and interpretation) and random (performer) effects, and similarity analyses to compare expressive profiles on a note-by-note basis across pieces and expressive parameters. Twelve professional harpsichordists recorded three pieces representative of the Baroque harpsichord repertoire, including three interpretations of one of these pieces, each emphasizing a different melodic line, on an instrument equipped with a MIDI console. Four expressive parameters were analyzed: articulation, note onset asynchrony, timing, and velocity. LMMs showed that piece-specific influences were much larger for articulation than for other parameters, for which performer-specific effects were predominant, and that piece-specific influences were generally larger than effects associated with interpretive goals. Some performers consistently deviated from the mean values for articulation and velocity across pieces and interpretations, suggesting that global measures of expressivity may in some cases constitute valid markers of artistic individuality. Similarity analyses detected significant associations among the magnitudes of the correlations between the expressive profiles of different performers. These associations were found both when comparing across parameters and within the same piece or interpretation, or on the same parameter and across pieces or interpretations. These findings suggest the existence of expressive meta-strategies that can manifest themselves across pieces, interpretive goals, or expressive devices. PMID:24348446

Quantifying and predicting interpretational uncertainty in cross-sections

NASA Astrophysics Data System (ADS)

Randle, Charles; Bond, Clare; Monaghan, Alison; Lark, Murray

2015-04-01

Cross-sections are often constructed from data to create a visual impression of the geologist's interpretation of the sub-surface geology. However as with all interpretations, this vision of the sub-surface geology is uncertain. We have designed and carried out an experiment with the aim of quantifying the uncertainty in geological cross-sections created by experts interpreting borehole data. By analysing different attributes of the data and interpretations we reflect on the main controls on uncertainty. A group of ten expert modellers at the British Geological Survey were asked to interpret an 11.4 km long cross-section from south-east Glasgow, UK. The data provided consisted of map and borehole data of the superficial deposits and shallow bedrock. Each modeller had a unique set of 11 boreholes removed from their dataset, to which their interpretations of the top of the bedrock were compared. This methodology allowed quantification of how far from the 'correct answer' each interpretation is at 11 points along each interpreted cross-section line; through comparison of the interpreted and actual bedrock elevations in the boreholes. This resulted in the collection of 110 measurements of the error to use in further analysis. To determine the potential control on uncertainty various attributes relating to the modeller, the interpretation and the data were recorded. Modellers were asked to fill out a questionnaire asking for information; such as how much 3D modelling experience they had, and how long it took them to complete the interpretation. They were also asked to record their confidence in their interpretations graphically, in the form of a confidence level drawn onto the cross-section. Initial analysis showed the majority of the experts' interpreted bedrock elevations within 5 metres of those recorded in the withheld boreholes. Their distribution is peaked and symmetrical about a mean of zero, indicating that there was no tendency for the experts to either under or over estimate the elevation of the bedrock. More complex analysis was completed in the form of linear mixed effects modelling. The modelling was used to determine if there were any correlations between the error and any other parameter recorded in the questionnaire, section or the initial dataset. This has resulted in the determination of both data based and interpreter based controls on uncertainty, adding insight into how uncertainty can be predicted, as well as how interpretation workflows can be improved. Our results will inform further experiments across a wide variety of geological situations to build understanding and best practice workflows for cross-section interpretation to reduce uncertainty.

An Original Stepwise Multilevel Logistic Regression Analysis of Discriminatory Accuracy: The Case of Neighbourhoods and Health

PubMed Central

Wagner, Philippe; Ghith, Nermin; Leckie, George

2016-01-01

Background and Aim Many multilevel logistic regression analyses of “neighbourhood and health” focus on interpreting measures of associations (e.g., odds ratio, OR). In contrast, multilevel analysis of variance is rarely considered. We propose an original stepwise analytical approach that distinguishes between “specific” (measures of association) and “general” (measures of variance) contextual effects. Performing two empirical examples we illustrate the methodology, interpret the results and discuss the implications of this kind of analysis in public health. Methods We analyse 43,291 individuals residing in 218 neighbourhoods in the city of Malmö, Sweden in 2006. We study two individual outcomes (psychotropic drug use and choice of private vs. public general practitioner, GP) for which the relative importance of neighbourhood as a source of individual variation differs substantially. In Step 1 of the analysis, we evaluate the OR and the area under the receiver operating characteristic (AUC) curve for individual-level covariates (i.e., age, sex and individual low income). In Step 2, we assess general contextual effects using the AUC. Finally, in Step 3 the OR for a specific neighbourhood characteristic (i.e., neighbourhood income) is interpreted jointly with the proportional change in variance (i.e., PCV) and the proportion of ORs in the opposite direction (POOR) statistics. Results For both outcomes, information on individual characteristics (Step 1) provide a low discriminatory accuracy (AUC = 0.616 for psychotropic drugs; = 0.600 for choosing a private GP). Accounting for neighbourhood of residence (Step 2) only improved the AUC for choosing a private GP (+0.295 units). High neighbourhood income (Step 3) was strongly associated to choosing a private GP (OR = 3.50) but the PCV was only 11% and the POOR 33%. Conclusion Applying an innovative stepwise multilevel analysis, we observed that, in Malmö, the neighbourhood context per se had a negligible influence on individual use of psychotropic drugs, but appears to strongly condition individual choice of a private GP. However, the latter was only modestly explained by the socioeconomic circumstances of the neighbourhoods. Our analyses are based on real data and provide useful information for understanding neighbourhood level influences in general and on individual use of psychotropic drugs and choice of GP in particular. However, our primary aim is to illustrate how to perform and interpret a multilevel analysis of individual heterogeneity in social epidemiology and public health. Our study shows that neighbourhood “effects” are not properly quantified by reporting differences between neighbourhood averages but rather by measuring the share of the individual heterogeneity that exists at the neighbourhood level. PMID:27120054

Using and Interpreting Mental Health Measures in the National Social Life, Health, and Aging Project

PubMed Central

Payne, Carolyn; Hedberg, E. C.; Kozloski, Michael; Dale, William

2014-01-01

Introduction. National Social Life, Health, and Aging Project (NSHAP) included five unique mental health measures in Waves 1 and 2 that researchers can use to measure the overall emotional health of participants: depressive symptoms, happiness–unhappiness, anxiety symptoms, perceived stress, and felt loneliness. For each, we detail the rationale for its development and explain how to score, analyze, and interpret results. Method. NSHAP developed its measures by modifying traditional short-form scales to improve response efficiency and reduce respondent burden. Scoring protocols and interpretations were developed for each measure. U.S. population estimates for older adults born between 1920 and 1947 were generated using age-eligible samples from Waves 1 and 2. Results. NSHAP’s protocols yielded U.S. prevalence rates similar to other nationally representative studies of older adults and comparable between waves. Higher estimates of anxiety symptoms and perceived stress in Wave 2 compared with Wave 1 were explained by age, administration mode, and time period. Analytic strategies for longitudinal analyses are provided. In Wave 2, mental health generally was worse at older ages, with women having more symptoms at younger ages than men. Women had fewer anxiety symptoms at the oldest ages. Discussion. NSHAP’s mental health measures were successfully integrated into the project’s survey and showed acceptable external reliability as well as moderately stable individual characteristics across the 5 years between Waves 1 and 2. Depressive symptoms and unhappiness may form a mental health cluster in the elderly, distinct from anxiety symptoms, perceived stress, and felt loneliness. Gender differences in age-specific patterns of mental health were evident using the exact age of participants rather than the traditional decade groupings. Administration mode and time period (between 2005–2006 and 2010–2011) were determined to be potential confounds that need to be accommodated in longitudinal analyses of aging, whereas sample composition was not an issue for interpreting mental health measures. PMID:25360028

Improving Deliverability in Gas Storage Fields by Identifying the Timing and Sources of Damage Using Smart Well Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.H. Frantz Jr; K.G. Brown; W.K. Sawyer

2006-03-01

This report summarizes the work performed under contract DE-FC26-03NT41743. The primary objective of this study was to develop tools that would allow Underground Gas Storage (UGS) operators to use wellhead electronic flow measurement (EFM) data to quickly and efficiently identify trends in well damage over time, thus aiding in the identification of potential causes of the damage. Secondary objectives of this work included: (1) To assist UGS operators in the evaluation of hardware and software requirements for implementing an EFM system similar to the one described in this report, and (2) To provide a cost-benefit analysis framework UGS operators canmore » use to evaluate economic benefits of installing wellhead EFM systems in their particular fields. Assessment of EFM data available for use, and selection of the specific study field are reviewed. The various EFM data processing tasks, including data collection, organization, extraction, processing, and interpretation are discussed. The process of damage assessment via pressure transient analysis of EFM data is outlined and demonstrated, including such tasks as quality control, semi-log analysis, and log-log analysis of pressure transient test data extracted from routinely collected EFM data. Output from pressure transient test analyses for 21 wells is presented, and the interpretation of these analyses to determine the timing of damage development is demonstrated using output from specific study wells. Development of processing and interpretation modules to handle EFM data interpretation in horizontal wells is also a presented and discussed. A spreadsheet application developed to aid underground gas storage operators in the selection of EFM equipment is presented, discussed, and used to determine the cost benefit of installing EFM equipment in a gas storage field. Recommendations for future work related to EFM in gas storage fields are presented and discussed.« less

Neural correlates of early-closure garden-path processing: Effects of prosody and plausibility.

PubMed

den Ouden, Dirk-Bart; Dickey, Michael Walsh; Anderson, Catherine; Christianson, Kiel

2016-01-01

Functional magnetic resonance imaging (fMRI) was used to investigate neural correlates of early-closure garden-path sentence processing and use of extrasyntactic information to resolve temporary syntactic ambiguities. Sixteen participants performed an auditory picture verification task on sentences presented with natural versus flat intonation. Stimuli included sentences in which the garden-path interpretation was plausible, implausible because of a late pragmatic cue, or implausible because of a semantic mismatch between an optionally transitive verb and the following noun. Natural sentence intonation was correlated with left-hemisphere temporal activation, but also with activation that suggests the allocation of more resources to interpretation when natural prosody is provided. Garden-path processing was associated with upregulation in bilateral inferior parietal and right-hemisphere dorsolateral prefrontal and inferior frontal cortex, while differences between the strength and type of plausibility cues were also reflected in activation patterns. Region of interest (ROI) analyses in regions associated with complex syntactic processing are consistent with a role for posterior temporal cortex supporting access to verb argument structure. Furthermore, ROI analyses within left-hemisphere inferior frontal gyrus suggest a division of labour, with the anterior-ventral part primarily involved in syntactic-semantic mismatch detection, the central part supporting structural reanalysis, and the posterior-dorsal part showing a general structural complexity effect.

Dynamics of crystalline acetanilide: Analysis using neutron scattering and computer simulation

NASA Astrophysics Data System (ADS)

Hayward, R. L.; Middendorf, H. D.; Wanderlingh, U.; Smith, J. C.

1995-04-01

The unusual temperature dependence of several optical spectroscopic vibrational bands in crystalline acetanilide has been interpreted as providing evidence for dynamic localization. Here we examine the vibrational dynamics of crystalline acetanilide over a spectral range of ˜20-4000 cm-1 using incoherent neutron scattering experiments, phonon normal mode calculations and molecular dynamics simulations. A molecular mechanics energy function is parametrized and used to perform the normal mode analyses in the full configurational space of the crystal i.e., including the intramolecular and intermolecular degrees of freedom. One- and multiphonon incoherent inelastic neutron scattering intensities are calculated from harmonic analyses in the first Brillouin zone and compared with the experimental data presented here. Phonon dispersion relations and mean-square atomic displacements are derived from the harmonic model and compared with data derived from coherent inelastic neutron scattering and neutron and x-ray diffraction. To examine the temperature effects on the vibrations the full, anharmonic potential function is used in molecular dynamics simulations of the crystal at 80, 140, and 300 K. Several, but not all, of the spectral features calculated from the molecular dynamics simulations exhibit temperature-dependent behavior in agreement with experiment. The significance of the results for the interpretation of the optical spectroscopic results and possible improvements to the model are discussed.

Quality care for persons experiencing dementia: the significance of relational ethics.

PubMed

Sellevold, Gerd S; Egede-Nissen, Veslemøy; Jakobsen, Rita; Sørlie, Venke

2013-05-01

The degree of success in creating quality care for people suffering from dementia is limited despite extensive research. This article describes healthcare providers' experience with the ethical challenges and possibilities in the relationship with patients suffering from dementia and its impact on quality care. The material is based on qualitative, in-depth individual narrative interviews with 12 professional healthcare providers from two different nursing homes. The transcribed interview texts were subjected to a phenomenological-hermeneutical interpretation. To provide quality care to patients with dementia, the healthcare providers emphasized the importance of sensing and understanding the patients' emotional and bodily expressions through sentient attentiveness and recognition of the patient as a person. They also described reciprocity of expressions in the relationship where the patient recognized them both as persons and healthcare providers. The analyses of the findings are, inter alia, discussed in light of Løgstrup's relational philosophy of ethics.

Molecular characterization of breast cancer cell lines through multiple omic approaches.

PubMed

Smith, Shari E; Mellor, Paul; Ward, Alison K; Kendall, Stephanie; McDonald, Megan; Vizeacoumar, Frederick S; Vizeacoumar, Franco J; Napper, Scott; Anderson, Deborah H

2017-06-05

Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained from the American Type Culture Collection (ATCC 30-4500 K) to enable researchers to make more informed decisions in selecting cell lines for specific studies. Information about these cell lines was obtained from a wide variety of sources. In addition, new information about cellular pathways that are activated within each cell line was generated. We determined key protein expression data using immunoblot analyses. In addition, two analyses on serum-starved cells were carried out to identify cellular proteins and pathways that are activated in these cells. These analyses were performed using a commercial PathScan array and a novel and more extensive phosphopeptide-based kinome analysis that queries 1290 phosphorylation events in major signaling pathways. Data about this panel of breast cancer cell lines was also accessed from several online sources, compiled and summarized for the following areas: molecular classification, mRNA expression, mutational status of key proteins and other possible cancer-associated mutations, and the tumorigenic and metastatic capacity in mouse xenograft models of breast cancer. The cell lines that were characterized included 10 estrogen receptor (ER)-positive, 12 human epidermal growth factor receptor 2 (HER2)-amplified and 18 triple negative breast cancer cell lines, in addition to 4 non-tumorigenic breast cell lines. Within each subtype, there was significant genetic heterogeneity that could impact both the selection of model cell lines and the interpretation of the results obtained. To capture the net activation of key signaling pathways as a result of these mutational combinations, profiled pathway activation status was examined. This provided further clarity for which cell lines were particularly deregulated in common or unique ways. These two new kinase or "Kin-OMIC" analyses add another dimension of important data about these frequently used breast cancer cell lines. This will assist researchers in selecting the most appropriate cell lines to use for breast cancer studies and provide context for the interpretation of the emerging results.

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smolders, R., E-mail: roel.smolders@vito.be; Den Hond, E.; Koppen, G.

In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother–child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality andmore » lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making. - Highlights: • External data was collected to interpret HBM data from DEMOCOPHES. • Hg in hair could be related to fish consumption across different countries. • Urinary cotinine was related to strictness of anti-smoking legislation. • Urinary Cd was borderline significantly related to air and food quality. • Lack of comparable data among countries hampered the analysis.« less

Medical Interpreters in Outpatient Practice.

PubMed

Jacobs, Barb; Ryan, Anne M; Henrichs, Katherine S; Weiss, Barry D

2018-01-01

This article provides an overview of the federal requirements related to providing interpreter services for non-English-speaking patients in outpatient practice. Antidiscrimination provisions in federal law require health programs and clinicians receiving federal financial assistance to take reasonable steps to provide meaningful access to individuals with limited English proficiency who are eligible for or likely to be encountered in their health programs or activities. Federal financial assistance includes grants, contracts, loans, tax credits and subsidies, as well as payments through Medicaid, the Children's Health Insurance Program, and most Medicare programs. The only exception is providers whose only federal assistance is through Medicare Part B, an exception that applies to a very small percentage of practicing physicians. All required language assistance services must be free and provided by qualified translators and interpreters. Interpreters must meet specified qualifications and ideally be certified. Although the cost of interpreter services can be considerable, ranging from $45-$150/hour for in-person interpreters, to $1.25-$3.00/minute for telephone interpreters, and $1.95-$3.49/minute for video remote interpreting, it may be reimbursed or covered by a patient's Medicaid or other federally funded medical insurance. Failure to use qualified interpreters can have serious negative consequences for both practitioners and patients. In one study, 1 of every 40 malpractice claims were related, all or in part, to failure to provide appropriate interpreter services. Most importantly, however, the use of qualified interpreters results in better and more efficient patient care. © 2018 Annals of Family Medicine, Inc.

Multivariate analyses of Erzgebirge granite and rhyolite composition: Implications for classification of granites and their genetic relations

USGS Publications Warehouse

Forster, H.-J.; Davis, J.C.; Tischendorf, G.; Seltmann, R.

1999-01-01

High-precision major, minor and trace element analyses for 44 elements have been made of 329 Late Variscan granitic and rhyolitic rocks from the Erzgebirge metallogenic province of Germany. The intrusive histories of some of these granites are not completely understood and exposures of rock are not adequate to resolve relationships between what apparently are different plutons. Therefore, it is necessary to turn to chemical analyses to decipher the evolution of the plutons and their relationships. A new classification of Erzgebirge plutons into five major groups of granites, based on petrologic interpretations of geochemical and mineralogical relationships (low-F biotite granites; low-F two-mica granites; high-F, high-P2O5 Li-mica granites; high-F, low-P2O5 Li-mica granites; high-F, low-P2O5 biotite granites) was tested by multivariate techniques. Canonical analyses of major elements, minor elements, trace elements and ratio variables all distinguish the groups with differing amounts of success. Univariate ANOVA's, in combination with forward-stepwise and backward-elimination canonical analyses, were used to select ten variables which were most effective in distinguishing groups. In a biplot, groups form distinct clusters roughly arranged along a quadratic path. Within groups, individual plutons tend to be arranged in patterns possibly reflecting granitic evolution. Canonical functions were used to classify samples of rhyolites of unknown association into the five groups. Another canonical analysis was based on ten elements traditionally used in petrology and which were important in the new classification of granites. Their biplot pattern is similar to that from statistically chosen variables but less effective at distinguishing the five groups of granites. This study shows that multivariate statistical techniques can provide significant insight into problems of granitic petrogenesis and may be superior to conventional procedures for petrological interpretation.

Semantic Space as a Metapopulation System: Modelling the Wikipedia Information Flow Network

NASA Astrophysics Data System (ADS)

Masucci, A. Paolo; Kalampokis, Alkiviadis; Eguíluz, Víctor M.; Hernández-García, Emilio

The meaning of a word can be defined as an indefinite set of interpretants, which are other words that circumscribe the semantic content of the word they represent (Derrida 1982). In the same way each interpretant has a set of interpretants representing it and so on. Hence the indefinite chain of meaning assumes a rhizomatic shape that can be represented and analysed via the modern techniques of network theory (Dorogovtsev and Mendes 2013).

"When I saw walking I just kind of took it as wheeling": interpretations of mobility-related items in generic, preference-based health state instruments in the context of spinal cord injury.

PubMed

Michel, Yvonne Anne; Engel, Lidia; Rand-Hendriksen, Kim; Augestad, Liv Ariane; Whitehurst, David Gt

2016-11-28

In health economic analyses, health states are typically valued using instruments with few items per dimension. Due to the generic (and often reductionist) nature of such instruments, certain groups of respondents may experience challenges in describing their health state. This study is concerned with generic, preference-based health state instruments that provide information for decisions about the allocation of resources in health care. Unlike physical measurement instruments, preference-based health state instruments provide health state values that are dependent on how respondents interpret the items. This study investigates how individuals with spinal cord injury (SCI) interpret mobility-related items contained within six preference-based health state instruments. Secondary analysis of focus group transcripts originally collected in Vancouver, Canada, explored individuals' perceptions and interpretations of mobility-related items contained within the 15D, Assessment of Quality of Life 8-dimension (AQoL-8D), EQ-5D-5L, Health Utilities Index (HUI), Quality of Well-Being Scale Self-Administered (QWB-SA), and the 36-item Short Form health survey version 2 (SF-36v2). Ritchie and Spencer's 'Framework Approach' was used to perform thematic analysis that focused on participants' comments concerning the mobility-related items only. Fifteen individuals participated in three focus groups (five per focus group). Four themes emerged: wording of mobility (e.g., 'getting around' vs 'walking'), reference to aids and appliances, lack of suitable response options, and reframing of items (e.g., replacing 'walking' with 'wheeling'). These themes reflected item features that respondents perceived as relevant in enabling them to describe their mobility, and response strategies that respondents could use when faced with inaccessible items. Investigating perceptions to mobility-related items within the context of SCI highlights substantial variation in item interpretation across six preference-based health state instruments. Studying respondents' interpretations of items can help to understand discrepancies in the health state descriptions and values obtained from different instruments. This line of research warrants closer attention in the health economics and quality of life literature.

How Methodologic Differences Affect Results of Economic Analyses: A Systematic Review of Interferon Gamma Release Assays for the Diagnosis of LTBI

PubMed Central

Oxlade, Olivia; Pinto, Marcia; Trajman, Anete; Menzies, Dick

2013-01-01

Introduction Cost effectiveness analyses (CEA) can provide useful information on how to invest limited funds, however they are less useful if different analysis of the same intervention provide unclear or contradictory results. The objective of our study was to conduct a systematic review of methodologic aspects of CEA that evaluate Interferon Gamma Release Assays (IGRA) for the detection of Latent Tuberculosis Infection (LTBI), in order to understand how differences affect study results. Methods A systematic review of studies was conducted with particular focus on study quality and the variability in inputs used in models used to assess cost-effectiveness. A common decision analysis model of the IGRA versus Tuberculin Skin Test (TST) screening strategy was developed and used to quantify the impact on predicted results of observed differences of model inputs taken from the studies identified. Results Thirteen studies were ultimately included in the review. Several specific methodologic issues were identified across studies, including how study inputs were selected, inconsistencies in the costing approach, the utility of the QALY (Quality Adjusted Life Year) as the effectiveness outcome, and how authors choose to present and interpret study results. When the IGRA versus TST test strategies were compared using our common decision analysis model predicted effectiveness largely overlapped. Implications Many methodologic issues that contribute to inconsistent results and reduced study quality were identified in studies that assessed the cost-effectiveness of the IGRA test. More specific and relevant guidelines are needed in order to help authors standardize modelling approaches, inputs, assumptions and how results are presented and interpreted. PMID:23505412

Mineral and Lithology Mapping of Drill Core Pulps Using Visible and Infrared Spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, G. R., E-mail: G.Taylor@unsw.edu.au

2000-12-15

A novel approach for using field spectrometry for determining both the mineralogy and the lithology of drill core pulps (powders) is developed and evaluated. The methodology is developed using material from a single drillhole through a mineralized sequence of rocks from central New South Wales. Mineral library spectra are used in linear unmixing routines to determine the mineral abundances in drill core pulps that represent between 1 m and 3 m of core. Comparison with X-Ray Diffraction (XRD) analyses shows that for most major constituents, spectrometry provides an estimate of quantitative mineralogy that is as reliable as that provided bymore » XRD. Confusion between the absorption features of calcite and those of chlorite causes the calcite contents determined by spectrometry to be unreliable. Convex geometry is used to recognize the spectra of those samples that are extreme and are representative of unique lithologies. Linear unmixing is used to determine the abundance of these lithologies in each drillhole sample and these abundances are used to interpret the geology of the drillhole. The interpreted geology agrees well with conventional drillhole logs of the visible geology and photographs of the split core. The methods developed provide a quick and cost-effective way of determining the lithology and alteration mineralogy of drill core pulps.« less

Photogrammetry and photo interpretation applied to analyses of cloud cover, cloud type, and cloud motion

NASA Technical Reports Server (NTRS)

Larsen, P. A.

1972-01-01

A determination was made of the areal extent of terrain obscured by clouds and cloud shadows on a portion of an Apollo 9 photograph at the instant of exposure. This photogrammetrically determined area was then compared to the cloud coverage reported by surface weather observers at approximately the same time and location, as a check on result quality. Stereograms prepared from Apollo 9 vertical photographs, illustrating various percentages of cloud coverage, are presented to help provide a quantitative appreciation of the degradation of terrain photography by clouds and their attendant shadows. A scheme, developed for the U.S. Navy, utilizing pattern recognition techniques for determining cloud motion from sequences of satellite photographs, is summarized. Clouds, turbulence, haze, and solar altitude, four elements of our natural environment which affect aerial photographic missions, are each discussed in terms of their effects on imagery obtained by aerial photography. Data of a type useful to aerial photographic mission planners, expressing photographic ground coverage in terms of flying height above terrain and camera focal length, for a standard aerial photograph format, are provided. Two oblique orbital photographs taken during the Apollo 9 flight are shown, and photo-interpretations, discussing the cloud types imaged and certain visible geographical features, are provided.

Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics

PubMed Central

2011-01-01

Background Clinical researchers have often preferred to use a fixed effects model for the primary interpretation of a meta-analysis. Heterogeneity is usually assessed via the well known Q and I2 statistics, along with the random effects estimate they imply. In recent years, alternative methods for quantifying heterogeneity have been proposed, that are based on a 'generalised' Q statistic. Methods We review 18 IPD meta-analyses of RCTs into treatments for cancer, in order to quantify the amount of heterogeneity present and also to discuss practical methods for explaining heterogeneity. Results Differing results were obtained when the standard Q and I2 statistics were used to test for the presence of heterogeneity. The two meta-analyses with the largest amount of heterogeneity were investigated further, and on inspection the straightforward application of a random effects model was not deemed appropriate. Compared to the standard Q statistic, the generalised Q statistic provided a more accurate platform for estimating the amount of heterogeneity in the 18 meta-analyses. Conclusions Explaining heterogeneity via the pre-specification of trial subgroups, graphical diagnostic tools and sensitivity analyses produced a more desirable outcome than an automatic application of the random effects model. Generalised Q statistic methods for quantifying and adjusting for heterogeneity should be incorporated as standard into statistical software. Software is provided to help achieve this aim. PMID:21473747

Methodological Standards for Meta-Analyses and Qualitative Systematic Reviews of Cardiac Prevention and Treatment Studies: A Scientific Statement From the American Heart Association.

PubMed

Rao, Goutham; Lopez-Jimenez, Francisco; Boyd, Jack; D'Amico, Frank; Durant, Nefertiti H; Hlatky, Mark A; Howard, George; Kirley, Katherine; Masi, Christopher; Powell-Wiley, Tiffany M; Solomonides, Anthony E; West, Colin P; Wessel, Jennifer

2017-09-05

Meta-analyses are becoming increasingly popular, especially in the fields of cardiovascular disease prevention and treatment. They are often considered to be a reliable source of evidence for making healthcare decisions. Unfortunately, problems among meta-analyses such as the misapplication and misinterpretation of statistical methods and tests are long-standing and widespread. The purposes of this statement are to review key steps in the development of a meta-analysis and to provide recommendations that will be useful for carrying out meta-analyses and for readers and journal editors, who must interpret the findings and gauge methodological quality. To make the statement practical and accessible, detailed descriptions of statistical methods have been omitted. Based on a survey of cardiovascular meta-analyses, published literature on methodology, expert consultation, and consensus among the writing group, key recommendations are provided. Recommendations reinforce several current practices, including protocol registration; comprehensive search strategies; methods for data extraction and abstraction; methods for identifying, measuring, and dealing with heterogeneity; and statistical methods for pooling results. Other practices should be discontinued, including the use of levels of evidence and evidence hierarchies to gauge the value and impact of different study designs (including meta-analyses) and the use of structured tools to assess the quality of studies to be included in a meta-analysis. We also recommend choosing a pooling model for conventional meta-analyses (fixed effect or random effects) on the basis of clinical and methodological similarities among studies to be included, rather than the results of a test for statistical heterogeneity. © 2017 American Heart Association, Inc.

Is intramedullary fixation of displaced midshaft clavicle fracture superior to plate fixation? Evidence from a systematic review of discordant meta-analyses.

PubMed

Xu, Bin; Lin, Yongsheng; Wang, Zhihong; Cao, Junming; Yang, Yipeng; Xia, Hehuan; Zhang, Yingze

2017-07-01

An increasing number of meta-analyses comparing intramedullary fixation (IF) with plate fixation (PF) for displaced midshaft clavicle fracture have been reported, but the inconsistent results obtained might confuse decision-making. We systematically reviewed discordant meta-analyses for assisting the decision-maker in interpreting and selecting amongst discordant meta-analyses and providing surgical recommendations for displaced midshaft clavicle fracture according to currently best available evidence. Meta-analyses on IF and PF for displaced midshaft clavicle fracture were identified by searching PubMed, Emabase and the Cochrane Library. A review of meta-analysis quality and data extraction was individually conducted by two reviewers. The meta-analysis providing the best available evidence was identified using the Jadad decision algorithm. Nine studies were included, five of which were of Level-II evidence and four of which were of Level-III evidence. These meta-analyses scored from 6 to 10 according to the Assessment of Multiple Systematic Reviews instrument. With respect to the Jadad decision algorithm, the best meta-analysis was chosen depending upon publication characteristics and methodology of primary studies, language restrictions, and whether data on individual patients were analysed. A meta-analysis incorporating more randomised controlled trials was eventually selected. The best available evidence indicated that the differences between IF and PF were not significant in terms of shoulder function or the rate of treatment failure. However, IF significantly decreased the operative time and the rate of non-operative complications, especially the rate of infection. Based on the best available evidence, IF may be superior to PF for treating displaced midshaft clavicle fracture. Copyright © 2017. Published by Elsevier Ltd.

Interrogating Paradigmatic and Narrative Analyses against a Backdrop of Teacher Professionalism

ERIC Educational Resources Information Center

MacMath, Sheryl

2009-01-01

In response to Denzin and Lincoln's claim that using a variety of interpretive analyses enables a better understanding of the world, I examine two different analyses of the same data set. Using a survey of preservice elementary education students (n = 208) asked to describe their perceptions of teacher professionalism, I contrast the application…

Intentions and actions in molecular self-assembly: perspectives on students' language use

NASA Astrophysics Data System (ADS)

Höst, Gunnar E.; Anward, Jan

2017-04-01

Learning to talk science is an important aspect of learning to do science. Given that scientists' language frequently includes intentions and purposes in explanations of unobservable objects and events, teachers must interpret whether learners' use of such language reflects a scientific understanding or inaccurate anthropomorphism and teleology. In the present study, a framework consisting of three 'stances' (Dennett, 1987) - intentional, design and physical - is presented as a powerful tool for analysing students' language use. The aim was to investigate how the framework can be differentiated and used analytically for interpreting students' talk about a molecular process. Semi-structured group discussions and individual interviews about the molecular self-assembly process were conducted with engineering biology/chemistry (n = 15) and biology/chemistry teacher students (n = 6). Qualitative content analysis of transcripts showed that all three stances were employed by students. The analysis also identified subcategories for each stance, and revealed that intentional language with respect to molecular movement and assumptions about design requirements may be potentially problematic areas. Students' exclusion of physical stance explanations may indicate literal anthropomorphic interpretations. Implications for practice include providing teachers with a tool for scaffolding their use of metaphorical language and for supporting students' metacognitive development as scientific language users.

Family members of older persons with multi-morbidity and their experiences of case managers in Sweden: an interpretive phenomenological approach.

PubMed

Hjelm, Markus; Holmgren, Ann-Charlotte; Willman, Ania; Bohman, Doris; Holst, Göran

2015-01-01

Family members of older persons (75+) with multi-morbidity are likely to benefit from utilising case management services performed by case managers. However, research has not yet explored their experiences of case managers. The aim of the study was to deepen the understanding of the importance of case managers to family members of older persons (75+) with multi-morbidity. The study design was based on an interpretive phenomenological approach. Data were collected through individual interviews with 16 family members in Sweden. The interviews were analysed by means of an interpretive phenomenological approach. The findings revealed one overarching theme: "Helps to fulfil my unmet needs", based on three sub-themes: (1) "Helps me feel secure - Experiencing a trusting relationship", (2) "Confirms and strengthens me - Challenging my sense of being alone" and (3) "Being my personal guide - Increasing my competence". The findings indicate that case managers were able to fulfil unmet needs of family members. The latter recognised the importance of case managers providing them with professional services tailored to their individual needs. The findings can contribute to the improvement of case management models not only for older persons but also for their family members.

30 CFR 251.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., identification of lithologic and fossil content, core analyses, laboratory analyses of physical and chemical..., often in the form of schematic cross sections, 3-dimensional representations, and maps, developed by.... Interpreted geophysical information means knowledge, often in the form of seismic cross sections, 3...

ILDgenDB: integrated genetic knowledge resource for interstitial lung diseases (ILDs).

PubMed

Mishra, Smriti; Shah, Mohammad I; Sarkar, Malay; Asati, Nimisha; Rout, Chittaranjan

2018-01-01

Interstitial lung diseases (ILDs) are a diverse group of ∼200 acute and chronic pulmonary disorders that are characterized by variable amounts of inflammation, fibrosis and architectural distortion with substantial morbidity and mortality. Inaccurate and delayed diagnoses increase the risk, especially in developing countries. Studies have indicated the significant roles of genetic elements in ILDs pathogenesis. Therefore, the first genetic knowledge resource, ILDgenDB, has been developed with an objective to provide ILDs genetic data and their integrated analyses for the better understanding of disease pathogenesis and identification of diagnostics-based biomarkers. This resource contains literature-curated disease candidate genes (DCGs) enriched with various regulatory elements that have been generated using an integrated bioinformatics workflow of databases searches, literature-mining and DCGs-microRNA (miRNAs)-single nucleotide polymorphisms (SNPs) association analyses. To provide statistical significance to disease-gene association, ILD-specificity index and hypergeomatric test scores were also incorporated. Association analyses of miRNAs, SNPs and pathways responsible for the pathogenesis of different sub-classes of ILDs were also incorporated. Manually verified 299 DCGs and their significant associations with 1932 SNPs, 2966 miRNAs and 9170 miR-polymorphisms were also provided. Furthermore, 216 literature-mined and proposed biomarkers were identified. The ILDgenDB resource provides user-friendly browsing and extensive query-based information retrieval systems. Additionally, this resource also facilitates graphical view of predicted DCGs-SNPs/miRNAs and literature associated DCGs-ILDs interactions for each ILD to facilitate efficient data interpretation. Outcomes of analyses suggested the significant involvement of immune system and defense mechanisms in ILDs pathogenesis. This resource may potentially facilitate genetic-based disease monitoring and diagnosis.Database URL: http://14.139.240.55/ildgendb/index.php.

Does Training in Table Creation Enhance Table Interpretation? A Quasi-Experimental Study with Follow-Up

ERIC Educational Resources Information Center

Karazsia, Bryan T.; Wong, Kendal

2016-01-01

Quantitative and statistical literacy are core domains in the undergraduate psychology curriculum. An important component of such literacy includes interpretation of visual aids, such as tables containing results from statistical analyses. This article presents results of a quasi-experimental study with longitudinal follow-up that tested the…

Exploring the Complex Interplay of National Learning and Teaching Policy and Academic Development Practice

ERIC Educational Resources Information Center

Smith, Karen

2016-01-01

Academic developers are important interpreters of policy, yet little research has focussed on the interplay of policy and academic development practice. Using methods from critical discourse analysis, this article analyses a national learning and teaching policy, charts its development, and explores its interpretation by the academic development…

Exploring Prospective Secondary Mathematics Teachers' Interpretation of Student Thinking through Analysing Students' Work in Modelling

ERIC Educational Resources Information Center

Didis, Makbule Gozde; Erbas, Ayhan Kursat; Cetinkaya, Bulent; Cakiroglu, Erdinc; Alacaci, Cengiz

2016-01-01

Researchers point out the importance of teachers' knowledge of student thinking and the role of examining student work in various contexts to develop a knowledge base regarding students' ways of thinking. This study investigated prospective secondary mathematics teachers' interpretations of students' thinking as manifested in students' work that…

University Reform and Institutional Autonomy: A Framework for Analysing the Living Autonomy

ERIC Educational Resources Information Center

Maassen, Peter; Gornitzka, Åse; Fumasoli, Tatiana

2017-01-01

In this article we discuss recent university reforms aimed at enhancing university autonomy, highlighting various tensions in the underlying reform ideologies. We examine how the traditional interpretation of university autonomy has been expanded in the reform rationales. An analytical framework for studying how autonomy is interpreted and used…

Counterbalancing and Other Uses of Repeated-Measures Latin-Square Designs: Analyses and Interpretations.

ERIC Educational Resources Information Center

Reese, Hayne W.

1997-01-01

Recommends that when repeated-measures Latin-square designs are used to counterbalance treatments across a procedural variable or to reduce the number of treatment combinations given to each participant, effects be analyzed statistically, and that in all uses, researchers consider alternative interpretations of the variance associated with the…

California GAMA Special Study: Analysis of Carbamazepine, Oxcarbazepine and Metabolites as Wastewater Tracers in Water Resource Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, J. E.; Vu, A. K.; Esser, B. K.

2010-08-20

The Groundwater Ambient Monitoring and Assessment (GAMA) Program is a comprehensive groundwater quality monitoring program managed by the California State Water Resources Control Board (SWRCB). The GAMA Special Studies project provides analyses and interpretation of constituents of concern that allow assessment of current groundwater conditions. In addition, the Special Studies project develops analyses that will enhance the monitoring and assessment effort by focusing on specific constituents of concern and water quality parameters, such as disinfection byproducts (DBP), wastewater indicators, and redox conditions, as it relates to irrigation and groundwater management. This study developed a robust analytical method for the quantitationmore » of CBZ, OXC, CBZ-E, CBZ-DiOH, and CBZ-10-OH in wastewater treatement plant (WWTP) effluent and in groundwater in the parts per trillion range.« less

A summary of Viking sample-trench analyses for angles of internal friction and cohesions

NASA Technical Reports Server (NTRS)

Moore, H. J.; Clow, G. D.; Hutton, R. E.

1982-01-01

Analyses of sample trenches excavated on Mars, using a theory for plowing by narrow blades, provide estimates of the angles of internal friction and the cohesions of the Martian surface materials. Angles of internal friction appear to be the same as those of many terrestrial soils because they are generally between 27 degrees and 39 degrees. Drift material, at the Lander 1 site, has a low angle of internal friction (near 18 degrees). All the materials excavated have low cohesions, generally between 0.2 and 10 kPa. The occurrence of cross bedding, layers of crusts, and blocky slabs shows that these materials are heterogeneous and that they contain planes of weakness. The results reported here have significant implications for future landed missions, Martian eolian processes, and interpretation of infrared temperatures.

A naturalistic study of the directional interpretation process of discrete emotions during high-stakes table tennis matches.

PubMed

Martinent, Guillaume; Ferrand, Claude

2009-06-01

The purpose of this study was to explore the directional interpretation process of discrete emotions experienced by table tennis players during competitive matches by adopting a naturalistic qualitative video-assisted approach. Thirty self-confrontation interviews were conducted with 11 national table tennis players (2 or 3 matches per participants). Nine discrete emotions were identified through the inductive analyses of the participants' transcriptions: anger, anxiety, discouragement, disappointment, disgust, joy, serenity, relief, and hope. Inductive analyses revealed the emergence of 4 categories and 13 themes among the 9 discrete emotions: positive direction (increased concentration, increased motivation, increased confidence, positive sensations, and adaptive behaviors), negative direction (decreased concentration, decreased motivation, too confident, decreased confidence, negative sensations, and maladaptive behaviors), neutral direction (take more risk and take less risk), and no perceived influence on own performance. Results are discussed in terms of current research on directional interpretation and emotions in sport.

Investigation into stutter ratio variability between different laboratories.

PubMed

Bright, Jo-Anne; Curran, James M

2014-11-01

The determination of parameters such as stutter ratio is important to inform a laboratory's forensic DNA profile interpretation strategy. As part of a large data analysis project to implement a continuous model of DNA profile interpretation we analysed stutter ratio data from eight different forensic laboratories for the Promega PowerPlex(®) 21 multiplex. This allowed a comparison of inter laboratory variation. The maximum difference for any one laboratory from the average of the best fit determined by the model was 0.31%. These results indicate that stutter ratios calculated from samples analysed using the same profiling kit are not expected to differ between laboratories, even those using different capillary electrophoresis platforms. A common set of laboratory parameters are able to be generated and used for profile interpretation at all laboratories using the same multiplex and cycle number, potentially reducing the need for individual laboratories to determine stutter ratios. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Finite-Difference Modeling of Seismic Reflection Data in a Hard Rock Environment: An Example from the Mineralized Otago Schist, New Zealand

NASA Astrophysics Data System (ADS)

Leslie, A.; Gorman, A. R.

2004-12-01

The interpretation of seismic reflection data in non-sedimentary environments is problematic. In the Macraes Flat region near Dunedin (South Island, New Zealand), ongoing mining of mineralized schist has prompted the development of a seismic interpretation scheme that is capable of imaging a gold-bearing shear zone and associated mineralized structures accurately to the meter scale. The anisotropic and complex structural nature of this geological environment necessitates a cost-effective computer-based modeling technique that can provide information on the physical characteristics of the schist. Such a method has been tested on seismic data acquired in 1993 over a region that has since been excavated and logged. Correlation to measured structural data permits a direct comparison between the seismic data and the actual geology. Synthetic modeling utilizes a 2D visco-elastic finite difference routine to constrain the interpretation of observed seismic characteristics, including the velocity, anisotropy, and contrast, of the shear zone structures. Iterative refinements of the model result in a more representative synthetic model that most closely matches the seismic response. The comparison between the actual and synthetic seismic sections provides promising results that will be tested by new data acquisition over the summer of 2004/2005 to identify structures and zones of potential mineralization. As a downstream benefit, this research could also contribute to earthquake risk assessment analyses at active faults with similar characteristics.

Characterizing the role of the hippocampus during episodic simulation and encoding.

PubMed

Thakral, Preston P; Benoit, Roland G; Schacter, Daniel L

2017-12-01

The hippocampus has been consistently associated with episodic simulation (i.e., the mental construction of a possible future episode). In a recent study, we identified an anterior-posterior temporal dissociation within the hippocampus during simulation. Specifically, transient simulation-related activity occurred in relatively posterior portions of the hippocampus and sustained activity occurred in anterior portions. In line with previous theoretical proposals of hippocampal function during simulation, the posterior hippocampal activity was interpreted as reflecting a transient retrieval process for the episodic details necessary to construct an episode. In contrast, the sustained anterior hippocampal activity was interpreted as reflecting the continual recruitment of encoding and/or relational processing associated with a simulation. In the present study, we provide a direct test of these interpretations by conducting a subsequent memory analysis of our previously published data to assess whether successful encoding during episodic simulation is associated with the anterior hippocampus. Analyses revealed a subsequent memory effect (i.e., later remembered > later forgotten simulations) in the anterior hippocampus. The subsequent memory effect was transient and not sustained. Taken together, the current findings provide further support for a component process model of hippocampal function during simulation. That is, unique regions of the hippocampus support dissociable processes during simulation, which include the transient retrieval of episodic information, the sustained binding of such information into a coherent episode, and the transient encoding of that episode for later retrieval. © 2017 Wiley Periodicals, Inc.

Initial interpretation and evaluation of a profile-based classification system for the anxiety and mood disorders: Incremental validity compared to DSM-IV categories.

PubMed

Rosellini, Anthony J; Brown, Timothy A

2014-12-01

Limitations in anxiety and mood disorder diagnostic reliability and validity due to the categorical approach to classification used by the Diagnostic and Statistical Manual of Mental Disorders (DSM) have been long recognized. Although these limitations have led researchers to forward alternative classification schemes, few have been empirically evaluated. In a sample of 1,218 outpatients with anxiety and mood disorders, the present study examined the validity of Brown and Barlow's (2009) proposal to classify the anxiety and mood disorders using an integrated dimensional-categorical approach based on transdiagnostic emotional disorder vulnerabilities and phenotypes. Latent class analyses of 7 transdiagnostic dimensional indicators suggested that a 6-class (i.e., profile) solution provided the best model fit and was the most conceptually interpretable. Interpretation of the classes was further supported when compared with DSM diagnoses (i.e., within-class prevalence of diagnoses, using diagnoses to predict class membership). In addition, hierarchical multiple regression models were used to demonstrate the incremental validity of the profiles; class probabilities consistently accounted for unique variance in anxiety and mood disorder outcomes above and beyond DSM diagnoses. These results provide support for the potential development and utility of a hybrid dimensional-categorical profile approach to anxiety and mood disorder classification. In particular, the availability of dimensional indicators and corresponding profiles may serve as a useful complement to DSM diagnoses for both researchers and clinicians. (c) 2014 APA, all rights reserved.

Initial Interpretation and Evaluation of a Profile-Based Classification System for the Anxiety and Mood Disorders: Incremental Validity Compared to DSM-IV Categories

PubMed Central

Rosellini, Anthony J.; Brown, Timothy A.

2014-01-01

Limitations in anxiety and mood disorder diagnostic reliability and validity due to the categorical approach to classification used by the Diagnostic and Statistical Manual of Mental Disorders (DSM) have been long recognized. Although these limitations have led researchers to forward alternative classification schemes, few have been empirically evaluated. In a sample of 1,218 outpatients with anxiety and mood disorders, the present study examined the validity of Brown and Barlow's (2009) proposal to classify the anxiety and mood disorders using an integrated dimensional-categorical approach based on transdiagnostic emotional disorder vulnerabilities and phenotypes. Latent class analyses of seven transdiagnostic dimensional indicators suggested that a six-class (i.e., profile) solution provided the best model fit and was the most conceptually interpretable. Interpretation of the classes was further supported when compared with DSM-IV diagnoses (i.e., within-class prevalence of diagnoses, using diagnoses to predict class membership). In addition, hierarchical multiple regression models were used to demonstrate the incremental validity of the profiles; class probabilities consistently accounted for unique variance in anxiety and mood disorder outcomes above and beyond DSM diagnoses. These results provide support for the potential development and utility of a hybrid dimensional-categorical profile approach to anxiety and mood disorder classification. In particular, the availability of dimensional indicators and corresponding profiles may serve as a useful complement to DSM diagnoses for both researchers and clinicians. PMID:25265416

Advanced Monitoring to Improve Combustion Turbine/Combined Cycle Reliability, Availability & Maintainability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leonard Angello

2005-09-30

Power generators are concerned with the maintenance costs associated with the advanced turbines that they are purchasing. Since these machines do not have fully established Operation and Maintenance (O&M) track records, power generators face financial risk due to uncertain future maintenance costs. This risk is of particular concern, as the electricity industry transitions to a competitive business environment in which unexpected O&M costs cannot be passed through to consumers. These concerns have accelerated the need for intelligent software-based diagnostic systems that can monitor the health of a combustion turbine in real time and provide valuable information on the machine's performancemore » to its owner/operators. EPRI, Impact Technologies, Boyce Engineering, and Progress Energy have teamed to develop a suite of intelligent software tools integrated with a diagnostic monitoring platform that, in real time, interpret data to assess the 'total health' of combustion turbines. The 'Combustion Turbine Health Management System' (CTHMS) will consist of a series of 'Dynamic Link Library' (DLL) programs residing on a diagnostic monitoring platform that accepts turbine health data from existing monitoring instrumentation. CTHMS interprets sensor and instrument outputs, correlates them to a machine's condition, provide interpretative analyses, project servicing intervals, and estimate remaining component life. In addition, the CTHMS enables real-time anomaly detection and diagnostics of performance and mechanical faults, enabling power producers to more accurately predict critical component remaining useful life and turbine degradation.« less

Exploring the Impact of Language Services on Utilization and Clinical Outcomes for Diabetics

PubMed Central

Hacker, Karen; Choi, Yoon Susan; Trebino, Lisa; Hicks, LeRoi; Friedman, Elisa; Blanchfield, Bonnie; Gazelle, G. Scott

2012-01-01

Background Significant health disparities exist between limited English proficient and English-proficient patients. Little is known about the impact of language services on chronic disease outcomes such as for diabetes. Methods/Principal Findings To determine whether the amount and type of language services received during primary care visits had an impact on diabetes-related outcomes (hospitalization, emergency room utilization, glycemic control) in limited English proficient patients, a retrospective cohort design was utilized. Hospital and medical record data was examined for 1425 limited English proficient patients in the Cambridge Health Alliance diabetes registry. We categorized patients receiving usual care into 7 groups based on the amount and combination of language services (language concordant providers, formal interpretation and nothing) received at primary care visits during a 9 month period. Bivariate analyses and multiple logistic regression were used to determine relationships between language service categories and outcomes in the subsequent 6 months. Thirty-one percent of patients (445) had no documentation of interpreter use or seeing a language concordant provider in any visits. Patients who received 100% of their primary care visits with language concordant providers were least likely to have diabetes-related emergency department visits compared to other groups (p<0001) in the following 6 months. Patients with higher numbers of co-morbidities were more likely to receive formal interpretation. Conclusions/Significance Language concordant providers may help reduce health care utilization for limited English proficient patients with diabetes. However, given the lack of such providers in sufficient numbers to meet patients' communication needs, strategies are needed to both increase their numbers and ensure that the highest risk patients receive the most appropriate language services. In addition, systems serving diverse populations must clarify why some limited English proficient patients do not receive language services at some or all of their visits and whether this has an impact on quality of care. PMID:22675571

Diagnostic performance of dual-energy contrast-enhanced subtracted mammography in dense breasts compared to mammography alone: interobserver blind-reading analysis.

PubMed

Cheung, Yun-Chung; Lin, Yu-Ching; Wan, Yung-Liang; Yeow, Kee-Min; Huang, Pei-Chin; Lo, Yung-Feng; Tsai, Hsiu-Pei; Ueng, Shir-Hwa; Chang, Chee-Jen

2014-10-01

To analyse the accuracy of dual-energy contrast-enhanced spectral mammography in dense breasts in comparison with contrast-enhanced subtracted mammography (CESM) and conventional mammography (Mx). CESM cases of dense breasts with histological proof were evaluated in the present study. Four radiologists with varying experience in mammography interpretation blindly read Mx first, followed by CESM. The diagnostic profiles, consistency and learning curve were analysed statistically. One hundred lesions (28 benign and 72 breast malignancies) in 89 females were analysed. Use of CESM improved the cancer diagnosis by 21.2 % in sensitivity (71.5 % to 92.7 %), by 16.1 % in specificity (51.8 % to 67.9 %) and by 19.8 % in accuracy (65.9 % to 85.8 %) compared with Mx. The interobserver diagnostic consistency was markedly higher using CESM than using Mx alone (0.6235 vs. 0.3869 using the kappa ratio). The probability of a correct prediction was elevated from 80 % to 90 % after 75 consecutive case readings. CESM provided additional information with consistent improvement of the cancer diagnosis in dense breasts compared to Mx alone. The prediction of the diagnosis could be improved by the interpretation of a significant number of cases in the presence of 6 % benign contrast enhancement in this study. • DE-CESM improves the cancer diagnosis in dense breasts compared with mammography. • DE-CESM shows greater consistency than mammography alone by interobserver blind reading. • Diagnostic improvement of DE-CESM is independent of the mammographic reading experience.

A comparison of three types of stimulus material in undergraduate mental health nursing education.

PubMed

Stone, Teresa E; Levett-Jones, Tracy

2014-04-01

The paper discusses an innovative educational approach that compared the use of different textual forms as stimulus materials in the teaching of an introductory mental health course. Practitioners in many disciplines, including nursing, appreciate the value of narratives in making sense of experiences, challenging assumptions and enhancing learning: they enable exploration of reality from different perspectives and create an emotional resonance. Narratives help nursing students to uncover embedded meanings, values and beliefs; they can include written texts, illustrated texts or picture books. 180 students enrolled in an elective undergraduate nursing course. This project afforded students the choice of critically analysing (a) a chapter from one of two autobiographies, (b) an illustrated text, or (c) an illustration from a picture book. Each text was a narrative account from a personal or carer's perspective of the experience of mental illness. Their written submissions were then analysed by means of a qualitative descriptive approach. In analysis of the autobiographies students tended to paraphrase the authors' words and summarise their experiences. Those choosing the illustrated text were able to link the images and text, and provide a deeper and more insightful level of interpretation, albeit influenced by the author's personal account and expressed emotions; however, those analysing a picture book illustration demonstrated a surprising level of critical and creative thinking, and their interpretations were empathetic, insightful and thoughtful. The use of picture books, although not a common approach in nursing education, appears to engage students, challenge them to think more deeply, and stimulate their imagination. © 2013.

Morbidity study of extruder personnel with potential exposure to brominated dioxins and furans. II. Results of clinical laboratory studies.

PubMed

Ott, M G; Zober, A

1996-12-01

To test whether dioxins affect liver and thyroid function, lipid metabolism and glucose or immunological variables, in workers exposed to brominated dioxins and furans. 34 male production employees (29 were extruder operators) and eight technical support personnel were studied, all of whom were potentially exposed to polybrominated dibenzo-p-dioxins (PBDDs) and furans (PBDFs) during production of resins containing polybrominated diphenyl ethers (PBDEs). Controls were from a similar resin producing plant that did not use PBDEs. Blood samples were analysed for tetra, penta, and hexabrominated congeners, but 2,3,7,8-TBDD was the only exposure measure used in the regression analyses. Seven liver function indicators, five measures of blood lipids and glucose, four haematology and blood coagulation measures, and three measures of thyroid function were examined. None of the variables was statistically related to concentration of 2,3,7,8-TBDD in the regression analyses. Cigarette smoking was related to several outcomes at the 0.05 level: aspartate aminotransferase, alanine aminotransferase, glutamate dehydrogenase (GLDH), erythrocyte sedimentation rate, and white blood cell count. Body mass index was also related to alanine aminotransferase, gamma-glutamyltranspeptidase, cholinesterase, GLDH, cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, and glucose concentrations. No definitive associations between liver, blood lipid, thyroid, or immunological variables and exposure to brominated dioxins or blood lipid concentration of 2,3,7,8-TBDD were found. The study population was small and hence the findings must be interpreted with caution. Nevertheless, these results provide a base for interpreting the results of clinical studies in similarly exposed populations.

How to write a systematic review.

PubMed

Harris, Joshua D; Quatman, Carmen E; Manring, M M; Siston, Robert A; Flanigan, David C

2014-11-01

The role of evidence-based medicine in sports medicine and orthopaedic surgery is rapidly growing. Systematic reviews and meta-analyses are also proliferating in the medical literature. To provide the outline necessary for a practitioner to properly understand and/or conduct a systematic review for publication in a sports medicine journal. Review. The steps of a successful systematic review include the following: identification of an unanswered answerable question; explicit definitions of the investigation's participant(s), intervention(s), comparison(s), and outcome(s); utilization of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines and PROSPERO registration; thorough systematic data extraction; and appropriate grading of the evidence and strength of the recommendations. An outline to understand and conduct a systematic review is provided, and the difference between meta-analyses and systematic reviews is described. The steps necessary to perform a systematic review are fully explained, including the study purpose, search methodology, data extraction, reporting of results, identification of bias, and reporting of the study's main findings. Systematic reviews or meta-analyses critically appraise and formally synthesize the best existing evidence to provide a statement of conclusion that answers specific clinical questions. Readers and reviewers, however, must recognize that the quality and strength of recommendations in a review are only as strong as the quality of studies that it analyzes. Thus, great care must be used in the interpretation of bias and extrapolation of the review's findings to translation to clinical practice. Without advanced education on the topic, the reader may follow the steps discussed herein to perform a systematic review. © 2013 The Author(s).

30 CFR 580.1 - What definitions apply to this part?

Code of Federal Regulations, 2014 CFR

2014-07-01

... of lithologic and fossil content, core analyses, laboratory analyses of physical and chemical... the form of schematic cross sections, 3-dimensional representations, and maps, developed by.... Interpreted geophysical information means knowledge, often in the form of seismic cross sections, 3...

30 CFR 580.1 - What definitions apply to this part?

Code of Federal Regulations, 2013 CFR

2013-07-01

... of lithologic and fossil content, core analyses, laboratory analyses of physical and chemical... the form of schematic cross sections, 3-dimensional representations, and maps, developed by.... Interpreted geophysical information means knowledge, often in the form of seismic cross sections, 3...

30 CFR 580.1 - What definitions apply to this part?

Code of Federal Regulations, 2012 CFR

2012-07-01

... of lithologic and fossil content, core analyses, laboratory analyses of physical and chemical... the form of schematic cross sections, 3-dimensional representations, and maps, developed by.... Interpreted geophysical information means knowledge, often in the form of seismic cross sections, 3...

Analysis of the patient-therapist relationship in dynamic psychotherapy: an experimental study of transference interpretations.

PubMed

Høglend, Per; Amlo, Svein; Marble, Alice; Bøgwald, Kjell-Petter; Sørbye, Oystein; Sjaastad, Mary Cosgrove; Heyerdahl, Oscar

2006-10-01

The purpose of this study was to measure the effects of transference interpretations (the assumed core active ingredient) in dynamic psychotherapy, using an experimental design. One hundred patients were randomly assigned to two groups. One group received dynamic psychotherapy over 1 year, with a moderate level of transference interpretations, while the other group received dynamic psychotherapy with no transference interpretations. The most common axis I disorders were depression and anxiety disorders. Forty-six patients fulfilled the general criteria for personality disorder. Seven experienced psychotherapists treated patients in both groups. Five full sessions from each treatment were rated by two evaluators with process measures in order to document treatment integrity. Outcome variables were the Psychodynamic Functioning Scales, Inventory of Interpersonal Problems Scale-Circumplex version, Global Assessment of Functioning Scale, and Symptom Checklist-90-R. Quality of Object Relations Scale (lifelong pattern) and personality disorders were preselected as possible moderators of treatment effects. Change was assessed using linear-mixed models. Clinically significant change was also calculated. The authors could not demonstrate differential treatment effects between the groups. However, the moderator analyses showed that transference interpretations were more helpful for patients with a lifelong history of less mature object relations. Small negative effects were observed for patients with mature object relations. The authors could not show differences in average effectiveness between treatments. However, the moderator analyses indicated that treatment worked through different active ingredients for different patients. Contrary to common expectation, patients with poor object relations profited more from therapy with transference interpretations than from therapy with no transference interpretations.

Evaluating a CCD film digitizer: comparing interpretation accuracy with original film readings

NASA Astrophysics Data System (ADS)

Gitlin, Joseph N.; Scott, William W., Jr.; Bell, Kathryn; Narayan, Anand

2002-04-01

The purpose of the study was to determine if there were differences between the interpretations of radiographic images resulting from digitizing films using a recently developed CCD unit, and the readings of the original films. The general hypothesis to be tested was that there were no significant differences in the measures of accuracy, sensitivity, specificity and ROC analyses when the interpretations related to the two modes were compared. The authors selected 120 radiographic examinations for the study from departmental teaching files, which included chest, abdomen, extremity and other cases that were considered difficult to interpret. The authors also selected six specific abnormalities visualized on 60 of the cases as true positives to classify the reports. After anonymizing the patient identification, the films were digitized and independently interpreted by four board-certified radiologists. Each reader read all of the examinations, half on film alternators and the other half on a high-resolution soft-copy workstation. No reader interpreted the same examination more than once. As of this date, the preliminary results indicate that the hypothesis will be accepted, but more analyses of the data must be performed to confirm the early findings. The additional work will include complete verification of data entry and classification of interpretations, a detailed review of perceived image quality and completion of the ROC analysis by pairs of readers. If the results are confirmed, radiologists, other physicians and administrators will have another reliable option to conventional film practice through increased access to remote primary diagnosis and consultation using high-speed telecommunication media.

An analysis of narratives to identify critical thinking contexts in psychiatric clinical practice.

PubMed

Mun, Mi Suk

2010-02-01

The development of students' critical thinking abilities is one of the greatest challenges facing contemporary nursing educators. Nursing educators should know about what kind of contents or situations need critical thinking. The research was undertaken to identify the critical thinking contexts that nursing students confront in psychiatric clinical practices. Students were asked to document their everyday experience. The narratives were analysed and interpreted from the philosophical notion of hermeneutics. Four themes emerged as critical thinking contexts: anxiety, conflict, hyper-awareness, dilemmas. Writing narratives appear to provide opportunities for reflection in addition to facilitating critical thinking and communicative skills in students. Also, for the instructor, students' clinical narratives could provide insight to understand how students are thinking and to share student's personal difficulties.

Analyses of requirements for computer control and data processing experiment subsystems. Volume 2: ATM experiment S-056 image data processing system software development

NASA Technical Reports Server (NTRS)

1972-01-01

The IDAPS (Image Data Processing System) is a user-oriented, computer-based, language and control system, which provides a framework or standard for implementing image data processing applications, simplifies set-up of image processing runs so that the system may be used without a working knowledge of computer programming or operation, streamlines operation of the image processing facility, and allows multiple applications to be run in sequence without operator interaction. The control system loads the operators, interprets the input, constructs the necessary parameters for each application, and cells the application. The overlay feature of the IBSYS loader (IBLDR) provides the means of running multiple operators which would otherwise overflow core storage.

Sender–receiver systems and applying information theory for quantitative synthetic biology

PubMed Central

Barcena Menendez, Diego; Senthivel, Vivek Raj; Isalan, Mark

2015-01-01

Sender–receiver (S–R) systems abound in biology, with communication systems sending information in various forms. Information theory provides a quantitative basis for analysing these processes and is being applied to study natural genetic, enzymatic and neural networks. Recent advances in synthetic biology are providing us with a wealth of artificial S–R systems, giving us quantitative control over networks with a finite number of well-characterised components. Combining the two approaches can help to predict how to maximise signalling robustness, and will allow us to make increasingly complex biological computers. Ultimately, pushing the boundaries of synthetic biology will require moving beyond engineering the flow of information and towards building more sophisticated circuits that interpret biological meaning. PMID:25282688

Effects of language concordance and interpreter use on therapeutic alliance in Spanish-speaking integrated behavioral health care patients.

PubMed

Villalobos, Bianca T; Bridges, Ana J; Anastasia, Elizabeth A; Ojeda, Carlos A; Rodriguez, Juventino Hernandez; Gomez, Debbie

2016-02-01

The discrepancy between the growing number of Spanish speakers in the U.S. and the availability of bilingual providers creates a barrier to accessing quality mental health care. Use of interpreters provides one strategy for overcoming this linguistic barrier; however, concerns about whether sessions with interpreters, versus bilingual providers, impede therapeutic alliance remain. The current study explored associations between the use of interpreters and therapeutic alliance in a sample of 458 Spanish-speaking patients seen for integrated behavioral health visits at primary care clinics. Patients completed a brief (4 item) therapeutic alliance scale at their behavioral health appointment. In addition, to supplement the quantitative study data, a pilot study of 30 qualitative interviews was conducted with a new sample of 10 Spanish-speaking patients, 10 behavioral health consultants (BHCs), and 10 trained interpreters. Quantitative results showed that interpreter use did not relate to therapeutic alliance, even when controlling for relevant demographic variables. However, qualitative interviews suggested major themes regarding the relative benefits and challenges of using interpreters for patients, interpreters, and BHCs. In interviews, patients expressed a strong preference for bilingual providers. Benefits included greater privacy, sense of trust, and accuracy of communication. However, in their absence, interpreters were seen as increasing access to services and facilitating communication with providers, thereby addressing the behavioral health needs of patients with limited English proficiency. BHCs and interpreters emphasized the importance of interpreter training and a good collaborative relationship with interpreters to minimize negative effects on the quality of care. (c) 2016 APA, all rights reserved).

GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations

PubMed Central

Paila, Umadevi; Chapman, Brad A.; Kirchner, Rory; Quinlan, Aaron R.

2013-01-01

Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable challenge for medical genetics. We have developed GEMINI (GEnome MINIng), a flexible software package for exploring all forms of human genetic variation. Unlike existing tools, GEMINI integrates genetic variation with a diverse and adaptable set of genome annotations (e.g., dbSNP, ENCODE, UCSC, ClinVar, KEGG) into a unified database to facilitate interpretation and data exploration. Whereas other methods provide an inflexible set of variant filters or prioritization methods, GEMINI allows researchers to compose complex queries based on sample genotypes, inheritance patterns, and both pre-installed and custom genome annotations. GEMINI also provides methods for ad hoc queries and data exploration, a simple programming interface for custom analyses that leverage the underlying database, and both command line and graphical tools for common analyses. We demonstrate GEMINI's utility for exploring variation in personal genomes and family based genetic studies, and illustrate its ability to scale to studies involving thousands of human samples. GEMINI is designed for reproducibility and flexibility and our goal is to provide researchers with a standard framework for medical genomics. PMID:23874191

GUILD: GUidance for Information about Linking Data sets†

PubMed Central

Gilbert, Ruth; Lafferty, Rosemary; Hagger-Johnson, Gareth; Zhang, Li-Chun; Smith, Peter; Dibben, Chris; Goldstein, Harvey

2018-01-01

Abstract Record linkage of administrative and survey data is increasingly used to generate evidence to inform policy and services. Although a powerful and efficient way of generating new information from existing data sets, errors related to data processing before, during and after linkage can bias results. However, researchers and users of linked data rarely have access to information that can be used to assess these biases or take them into account in analyses. As linked administrative data are increasingly used to provide evidence to guide policy and services, linkage error, which disproportionately affects disadvantaged groups, can undermine evidence for public health. We convened a group of researchers and experts from government data providers to develop guidance about the information that needs to be made available about the data linkage process, by data providers, data linkers, analysts and the researchers who write reports. The guidance goes beyond recommendations for information to be included in research reports. Our aim is to raise awareness of information that may be required at each step of the linkage pathway to improve the transparency, reproducibility, and accuracy of linkage processes, and the validity of analyses and interpretation of results. PMID:28369581

Pesticides in the atmosphere: distribution, trends, and governing factors

USGS Publications Warehouse

Majewski, Michael S.; Capel, Paul D.

1996-01-01

Most people know about the presence and health effects of pesticide residues in the water they drink. However, they may not realize the impact of atmospheric transportation and deposition of pesticides on water quality. Scientific studies of pesticides in various atmospheric matrices (air, rain, snow, aerosols, and fog) provide some of the answers. Pesticides in the Atmosphere focuses on the review and interpretation of direct measurements of pesticides in the environment. An exhaustive compilation, the book examines hundreds of studies in detailed tabular listings, with accompanying maps that include such features as spatial and temporal domain studies, target analytes, detection limits, and compounds detected. Working with the foundation of forty years of scientific studies, the editors synthesize this research to characterize the common threads and main conclusions. They use this information to identify where we need to improve our understanding of pesticides in the atmosphere and their significance to water quality. Pesticides in the Atmosphere serves as a resource, text, and reference to a wide spectrum of scientists, water managers, and students. It includes extensive compilations of references, interpretive analyses and conclusions. For those not familiar with the atmospheric transportation and deposition of pesticides it provides a comprehensive introduction.

"What If" Analyses: Ways to Interpret Statistical Significance Test Results Using EXCEL or "R"

ERIC Educational Resources Information Center

Ozturk, Elif

2012-01-01

The present paper aims to review two motivations to conduct "what if" analyses using Excel and "R" to understand the statistical significance tests through the sample size context. "What if" analyses can be used to teach students what statistical significance tests really do and in applied research either prospectively to estimate what sample size…

Safety in home care: A research protocol for studying medication management

PubMed Central

2010-01-01

Background Patient safety is an ongoing global priority, with medication safety considered a prevalent, high-risk area of concern. Yet, we have little understanding of the supports and barriers to safe medication management in the Canadian home care environment. There is a clear need to engage the providers and recipients of care in studying and improving medication safety with collaborative approaches to exploring the nature and safety of medication management in home care. Methods A socio-ecological perspective on health and health systems drives our iterative qualitative study on medication safety with elderly home care clients, family members and other informal caregivers, and home care providers. As we purposively sample across four Canadian provinces: Alberta (AB), Ontario (ON), Quebec (QC) and Nova Scotia (NS), we will collect textual and visual data through home-based interviews, participant-led photo walkabouts of the home, and photo elicitation sessions at clients' kitchen tables. Using successive rounds of interpretive description and human factors engineering analyses, we will generate robust descriptions of managing medication at home within each provincial sample and across the four-province group. We will validate our initial interpretations through photo elicitation focus groups with home care providers in each province to develop a refined description of the phenomenon that can inform future decision-making, quality improvement efforts, and research. Discussion The application of interpretive and human factors lenses to the visual and textual data is expected to yield findings that advance our understanding of the issues, challenges, and risk-mitigating strategies related to medication safety in home care. The images are powerful knowledge translation tools for sharing what we learn with participants, decision makers, other healthcare audiences, and the public. In addition, participants engage in knowledge exchange throughout the study with the use of participatory data collection methods. PMID:20525363

Crater-based dating of geological units on Mars: methods and application for the new global geological map

USGS Publications Warehouse

Platz, Thomas; Michael, Gregory; Tanaka, Kenneth L.; Skinner, James A.; Fortezzo, Corey M.

2013-01-01

The new, post-Viking generation of Mars orbital imaging and topographical data provide significant higher-resolution details of surface morphologies, which induced a new effort to photo-geologically map the surface of Mars at 1:20,000,000 scale. Although from unit superposition relations a relative stratigraphical framework can be compiled, it was the ambition of this mapping project to provide absolute unit age constraints through crater statistics. In this study, the crater counting method is described in detail, starting with the selection of image data, type locations (both from the mapper’s and crater counter’s perspectives) and the identification of impact craters. We describe the criteria used to validate and analyse measured crater populations, and to derive and interpret crater model ages. We provide examples of how geological information about the unit’s resurfacing history can be retrieved from crater size–frequency distributions. Three cases illustrate short-, intermediate, and long-term resurfacing histories. In addition, we introduce an interpretation-independent visualisation of the crater resurfacing history that uses the reduction of the crater population in a given size range relative to the expected population given the observed crater density at larger sizes. From a set of potential type locations, 48 areas from 22 globally mapped units were deemed suitable for crater counting. Because resurfacing ages were derived from crater statistics, these secondary ages were used to define the unit age rather than the base age. Using the methods described herein, we modelled ages that are consistent with the interpreted stratigraphy. Our derived model ages allow age assignments to be included in unit names. We discuss the limitations of using the crater dating technique for global-scale geological mapping. Finally, we present recommendations for the documentation and presentation of crater statistics in publications.

Uniform circular motion in general relativity: existence and extendibility of the trajectories

NASA Astrophysics Data System (ADS)

de la Fuente, Daniel; Romero, Alfonso; Torres, Pedro J.

2017-06-01

The concept of uniform circular motion in a general spacetime is introduced as a particular case of a planar motion. The initial value problem of the corresponding differential equation is analysed in detail. Geometrically, an observer that obeys a uniform circular motion is characterized as a Lorentzian helix. The completeness of inextensible trajectories is studied in generalized Robertson-Walker spacetimes and in a relevant family of pp-wave spacetimes. Under reasonable assumptions, the physical interpretation of such results is that a uniform circular observer lives forever, providing the absence of the singularities defined by these timelike curves.

From "Anna O." to Bertha Pappenheim: transforming private pain into public action.

PubMed

Kimball, M M

2000-02-01

Bertha Pappenheim ("Anna O,") was treated for hysteria by Josef Breuer when she was a young adult. As a mature adult she became a leading social worker, writer, and feminist activist in the German Jewish community. This article examines her therapy with Breuer, her own struggle for recovery, and some links between her earlier and later life, in particular the lack of intimate relationships in her life and her work against the victimization of women. Throughout the article psychoanalytic interpretations, social history, and feminist analyses are integrated to provide a contextualized examination of Pappenheim's life.

Interpretive geologic bedrock map of the Tanana B-1 Quadrangle, Central Alaska

USGS Publications Warehouse

Reifenstuh, Rocky R.; Dover, James H.; Newberry, Rainer J.; Calutice, Karen H.; Liss, Shirley A.; Blodgett, Robert B.; Budtzen, Thomas K.; Weber, Florence R.

1997-01-01

This report provides detailed (1:63,360-scale) mapping of the Tanana B-1 Quadrangle (250 square miles; equivalent to four 7.5 minute quadrangles). The area is part of the Manley Hot Springs-Tofty mining districts and adjacent to the Rampart mining district to the north of the Tanana A-1 and A-2 Quadrangles. This report includes detailed bedrock, structural, stratigraphic, and geochronologic data. Based on the resulting geologic maps, field investigations, and laboratory materials analyses, the project has also generated derivative maps of geologic construction materials and geologic hazards.

An algorithm for automatic reduction of complex signal flow graphs

NASA Technical Reports Server (NTRS)

Young, K. R.; Hoberock, L. L.; Thompson, J. G.

1976-01-01

A computer algorithm is developed that provides efficient means to compute transmittances directly from a signal flow graph or a block diagram. Signal flow graphs are cast as directed graphs described by adjacency matrices. Nonsearch computation, designed for compilers without symbolic capability, is used to identify all arcs that are members of simple cycles for use with Mason's gain formula. The routine does not require the visual acumen of an interpreter to reduce the topology of the graph, and it is particularly useful for analyzing control systems described for computer analyses by means of interactive graphics.

30 CFR 280.1 - What definitions apply to this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... of lithologic and fossil content, core analyses, laboratory analyses of physical and chemical..., or sulphur. Interpreted geological information means the knowledge, often in the form of schematic... information means knowledge, often in the form of seismic cross sections, 3-dimensional representations, and...

Statistical analysis and interpretation of prenatal diagnostic imaging studies, Part 2: descriptive and inferential statistical methods.

PubMed

Tuuli, Methodius G; Odibo, Anthony O

2011-08-01

The objective of this article is to discuss the rationale for common statistical tests used for the analysis and interpretation of prenatal diagnostic imaging studies. Examples from the literature are used to illustrate descriptive and inferential statistics. The uses and limitations of linear and logistic regression analyses are discussed in detail.

Application of photometric analyses for interpretation of Mars-Mariner VI and VII imagery

NASA Technical Reports Server (NTRS)

Kinzly, R. E.

1977-01-01

The application of radiometric analysis in the interpretation of Mariner 6 and 7 imagery is investigated and illustrated. The following types of problems were felt could be addressed using this imagery: (1) evaluation of local reflectivity changes; (2) augmentation of geological mapping; (3) discrimination of atmospheric phenomena; and (4) investigation of polar cap structure.

Observations from Secondary School Classrooms in Trinidad and Tobago: Science Teachers' Use of Analogies

ERIC Educational Resources Information Center

Maharaj-Sharma, R.; Sharma, A.

2015-01-01

This study was undertaken to examine and interpret how science teachers in Trinidad and Tobago used analogies in their science teaching. A total of 30 lessons taught by five different teachers were observed and analysed using an interpretative research methodology to develop generalized observations. The findings revealed that in general science…

Missing data and multiple imputation in clinical epidemiological research.

PubMed

Pedersen, Alma B; Mikkelsen, Ellen M; Cronin-Fenton, Deirdre; Kristensen, Nickolaj R; Pham, Tra My; Pedersen, Lars; Petersen, Irene

2017-01-01

Missing data are ubiquitous in clinical epidemiological research. Individuals with missing data may differ from those with no missing data in terms of the outcome of interest and prognosis in general. Missing data are often categorized into the following three types: missing completely at random (MCAR), missing at random (MAR), and missing not at random (MNAR). In clinical epidemiological research, missing data are seldom MCAR. Missing data can constitute considerable challenges in the analyses and interpretation of results and can potentially weaken the validity of results and conclusions. A number of methods have been developed for dealing with missing data. These include complete-case analyses, missing indicator method, single value imputation, and sensitivity analyses incorporating worst-case and best-case scenarios. If applied under the MCAR assumption, some of these methods can provide unbiased but often less precise estimates. Multiple imputation is an alternative method to deal with missing data, which accounts for the uncertainty associated with missing data. Multiple imputation is implemented in most statistical software under the MAR assumption and provides unbiased and valid estimates of associations based on information from the available data. The method affects not only the coefficient estimates for variables with missing data but also the estimates for other variables with no missing data.

Missing data and multiple imputation in clinical epidemiological research

PubMed Central

Pedersen, Alma B; Mikkelsen, Ellen M; Cronin-Fenton, Deirdre; Kristensen, Nickolaj R; Pham, Tra My; Pedersen, Lars; Petersen, Irene

2017-01-01

Missing data are ubiquitous in clinical epidemiological research. Individuals with missing data may differ from those with no missing data in terms of the outcome of interest and prognosis in general. Missing data are often categorized into the following three types: missing completely at random (MCAR), missing at random (MAR), and missing not at random (MNAR). In clinical epidemiological research, missing data are seldom MCAR. Missing data can constitute considerable challenges in the analyses and interpretation of results and can potentially weaken the validity of results and conclusions. A number of methods have been developed for dealing with missing data. These include complete-case analyses, missing indicator method, single value imputation, and sensitivity analyses incorporating worst-case and best-case scenarios. If applied under the MCAR assumption, some of these methods can provide unbiased but often less precise estimates. Multiple imputation is an alternative method to deal with missing data, which accounts for the uncertainty associated with missing data. Multiple imputation is implemented in most statistical software under the MAR assumption and provides unbiased and valid estimates of associations based on information from the available data. The method affects not only the coefficient estimates for variables with missing data but also the estimates for other variables with no missing data. PMID:28352203

Functional Organization of the Action Observation Network in Autism: A Graph Theory Approach.

PubMed

Alaerts, Kaat; Geerlings, Franca; Herremans, Lynn; Swinnen, Stephan P; Verhoeven, Judith; Sunaert, Stefan; Wenderoth, Nicole

2015-01-01

The ability to recognize, understand and interpret other's actions and emotions has been linked to the mirror system or action-observation-network (AON). Although variations in these abilities are prevalent in the neuro-typical population, persons diagnosed with autism spectrum disorders (ASD) have deficits in the social domain and exhibit alterations in this neural network. Here, we examined functional network properties of the AON using graph theory measures and region-to-region functional connectivity analyses of resting-state fMRI-data from adolescents and young adults with ASD and typical controls (TC). Overall, our graph theory analyses provided convergent evidence that the network integrity of the AON is altered in ASD, and that reductions in network efficiency relate to reductions in overall network density (i.e., decreased overall connection strength). Compared to TC, individuals with ASD showed significant reductions in network efficiency and increased shortest path lengths and centrality. Importantly, when adjusting for overall differences in network density between ASD and TC groups, participants with ASD continued to display reductions in network integrity, suggesting that also network-level organizational properties of the AON are altered in ASD. While differences in empirical connectivity contributed to reductions in network integrity, graph theoretical analyses provided indications that also changes in the high-level network organization reduced integrity of the AON.

Overcoming language barriers in health care: costs and benefits of interpreter services.

PubMed

Jacobs, Elizabeth A; Shepard, Donald S; Suaya, Jose A; Stone, Esta-Lee

2004-05-01

We assessed the impact of interpreter services on the cost and the utilization of health care services among patients with limited English proficiency. We measured the change in delivery and cost of care provided to patients enrolled in a health maintenance organization before and after interpreter services were implemented. Compared with English-speaking patients, patients who used the interpreter services received significantly more recommended preventive services, made more office visits, and had more prescriptions written and filled. The estimated cost of providing interpreter services was $279 per person per year. Providing interpreter services is a financially viable method for enhancing delivery of health care to patients with limited English proficiency.

INTERPRETING FOR DEAF PEOPLE, A REPORT OF A WORKSHOP ON INTERPRETING (GOVERNOR BAXTER STATE SCHOOL FOR THE DEAF, PORTLAND, MAINE, JULY 7-27, 1965).

ERIC Educational Resources Information Center

QUIGLEY, STEPHEN P.; YOUNGS, JOSEPH P.

THIS MANUAL, A RESULT OF THE WORKSHOP ON INTERPRETING FOR THE DEAF WHICH WAS HELD AT THE GOVERNOR BAXTER STATE SCHOOL FOR THE DEAF IN MAINE, JULY, 1965, IS DESIGNED TO (1) DEFINE INTERPRETING PROBLEMS AND PROCEDURES, (2) PROVIDE CURRICULUM GUIDELINES, AND (3) PROVIDE INFORMATION FOR INSTRUCTORS AND STUDENTS IN CLASSES ON INTERPRETING. THE…

The State of Phylogenetic Analysis: Narrow Visions and Simple Answers-Examples from the Diptera (flies).

PubMed

Borkent, Art

2018-01-17

The order Diptera is remarkably diverse, not only in species but in morphological variation in every life stage, making them excellent candidates for phylogenetic analysis. Such analysis has been hampered by methods that have severely restricted character state interpretation. Morphological-based phylogenies should be based on a deep understanding of the morphology, development and function of character states, and have extensive outgroup comparisons made to determine their polarity. Character states clearly vary in their value for determining phylogenetic relationships and this needs to be studied and utilized. Characters themselves need more explicit discussion, including how some may be developmentally or functionally related to other characters (and potentially not independent indicators of genealogical relationship). The current practice by many, of filling a matrix with poorly understood character states and highly limited outgroup comparisons, is unacceptable if the results are to be a valid reflection of the actual history of the group.Parsimony analysis is not an objective interpretation of phylogenetic relationships when all characters are treated as equal in value. Exact mathematical values applied to characters are entirely arbitrary and are generally used to produce a phylogeny that the author considers as reasonable. Mathematical appraisal of a given node is similarly inconsequential because characters do not have an intrinsic mathematical value. Bremer support, for example, provides values that have no biological reality but provide the pretence of objectivity. Cladists need to focus their attention on testing the validity of each synapomorphy proposed, as the basis for all further phylogenetic interpretation, rather than the testing of differing phylogenies through various comparative programs.Current phylogenetic analyses have come to increasingly depend on DNA sequence-based characters, in spite of their tumultuous history of inconsistent results. Until such time as sequences can be shown to produce predictive phylogenies (i.e., using Hennigian logic), independent of morphological analysis, they should be viewed with caution and certainly not as a panacea as they are commonly portrayed.The purported comprehensive analyses of phylogenetic relationships between families of Diptera by Wiegmann et al. (2011) and Lambkin et al. (2013) have serious flaws and cannot be considered as the "Periodic Table" of such relationships as originally heralded.Systematists working on Diptera have a plethora of complex and informative morphological synapomorphies in every life stage, either described or awaiting study. Many lineages have the potential of providing a wealth of evolutionary stories to share with other biologists if we produce stable phylogenies based on weighted synapomorphies and interpreted to elucidate the zoogeographic and bionomic divergence of the group. Some lineages are devoid of convincing synapomorphies and, in spite of our desires, should be recognized as being largely uninterpretable.

Working with the Hmong Population in a Genetics Setting: an Interpreter Perspective.

PubMed

Krieger, Meghan; Agather, Aime; Douglass, Kathryn; Reiser, Catherine A; Petty, Elizabeth M

2018-06-01

The aim of this pilot qualitative study was to describe the experiences and beliefs of medical interpreters when working with genetic counselors and other genetic providers caring for Hmong patients who are not native English speakers. Specific goals were to identify interpreters' thoughts and perceptions on (a) their roles during sessions, (b) unique challenges in a genetics session, (c) knowledge genetics providers need when working with Hmong patients and interpreters, and (d) supports and training needed to effectively interpret in a genetics setting. Hmong medical interpreters from Wisconsin and Minnesota were invited by email to participate in the study. Six were interviewed by telephone. Participants had worked with a variety of providers including geneticists, genetic counselors, primary care physicians, and oncologists. Factors identified by Hmong interpreters that made interpretation of content difficult in clinical genetics sessions included: time constraints, technical terms, and unique cultural perspectives of Hmong patients. While all respondents felt their primary role was to interpret session content as close to verbatim as possible, there was notable variation in the description of their interpretation style and other perceived roles in the genetic counseling session. Cultural issues genetics providers could consider when working with Hmong patients and different style issues when working with Hmong interpreters are discussed. Ideas for future studies and suggestions to improve communication with Hmong patients are explored.

Clinical trials, epidemiology, and public confidence.

PubMed

Seigel, Daniel

2003-11-15

Critics in the media have become wary of exaggerated research claims from clinical trials and epidemiological studies. Closer to home, reviews of published studies find a high frequency of poor quality in research methods, including those used for statistical analysis. The statistical literature has long recognized that questionable research findings can occur when investigators fail to set aside their own outcome preferences as they analyse and interpret data. These preferences can be related to financial interests, a concern for patients, peer recognition, and commitment to a hypothesis. Several analyses of published papers provide evidence of an association between financial conflicts of interest and reported results. If we are to regain professional and lay confidence in research findings some changes are required. Clinical journals need to develop more competence in the review of analytic methods and provide space for thorough discussion of published papers whose results are challenged. Graduate schools need to prepare students for the conflicting interests that surround the practice of statistics. Above all, each of us must recognize our responsibility to use analytic procedures that illuminate the research issues rather than those serving special interests. Copyright 2003 John Wiley & Sons, Ltd.

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.

PubMed

Simovski, Boris; Kanduri, Chakravarthi; Gundersen, Sveinung; Titov, Dmytro; Domanska, Diana; Bock, Christoph; Bossini-Castillo, Lara; Chikina, Maria; Favorov, Alexander; Layer, Ryan M; Mironov, Andrey A; Quinlan, Aaron R; Sheffield, Nathan C; Trynka, Gosia; Sandve, Geir K

2018-06-05

Functional genomics assays produce sets of genomic regions as one of their main outputs. To biologically interpret such region-sets, researchers often use colocalization analysis, where the statistical significance of colocalization (overlap, spatial proximity) between two or more region-sets is tested. Existing colocalization analysis tools vary in the statistical methodology and analysis approaches, thus potentially providing different conclusions for the same research question. As the findings of colocalization analysis are often the basis for follow-up experiments, it is helpful to use several tools in parallel and to compare the results. We developed the Coloc-stats web service to facilitate such analyses. Coloc-stats provides a unified interface to perform colocalization analysis across various analytical methods and method-specific options (e.g. colocalization measures, resolution, null models). Coloc-stats helps the user to find a method that supports their experimental requirements and allows for a straightforward comparison across methods. Coloc-stats is implemented as a web server with a graphical user interface that assists users with configuring their colocalization analyses. Coloc-stats is freely available at https://hyperbrowser.uio.no/coloc-stats/.

Analyzing Longitudinal Data with Multilevel Models: An Example with Individuals Living with Lower Extremity Intra-articular Fractures

PubMed Central

Kwok, Oi-Man; Underhill, Andrea T.; Berry, Jack W.; Luo, Wen; Elliott, Timothy R.; Yoon, Myeongsun

2008-01-01

The use and quality of longitudinal research designs has increased over the past two decades, and new approaches for analyzing longitudinal data, including multi-level modeling (MLM) and latent growth modeling (LGM), have been developed. The purpose of this paper is to demonstrate the use of MLM and its advantages in analyzing longitudinal data. Data from a sample of individuals with intra-articular fractures of the lower extremity from the University of Alabama at Birmingham’s Injury Control Research Center is analyzed using both SAS PROC MIXED and SPSS MIXED. We start our presentation with a discussion of data preparation for MLM analyses. We then provide example analyses of different growth models, including a simple linear growth model and a model with a time-invariant covariate, with interpretation for all the parameters in the models. More complicated growth models with different between- and within-individual covariance structures and nonlinear models are discussed. Finally, information related to MLM analysis such as online resources is provided at the end of the paper. PMID:19649151

Utilizing Skylab data in on-going resources management programs in the state of Ohio

NASA Technical Reports Server (NTRS)

Baldridge, P. E. (Principal Investigator); Goesling, P. H.; Martin, T. A.; Wukelic, G. E.; Stephan, J. G.; Smail, H. E.; Ebbert, T. F.

1975-01-01

The author has identified the following significant results. The use of Skylab imagery for total area woodland surveys was found to be more accurate and cheaper than conventional surveys using aerial photo-plot techniques. Machine-aided (primarily density slicing) analyses of Skylab 190A and 190B color and infrared color photography demonstrated the feasibility of using such data for differentiating major timber classes including pines, hardwoods, mixed, cut, and brushland providing such analyses are made at scales of 1:24,000 and larger. Manual and machine-assisted image analysis indicated that spectral and spatial capabilities of Skylab EREP photography are adequate to distinguish most parameters of current, coal surface mining concern associated with: (1) active mining, (2) orphan lands, (3) reclaimed lands, and (4) active reclamation. Excellent results were achieved when comparing Skylab and aerial photographic interpretations of detailed surface mining features. Skylab photographs when combined with other data bases (e.g., census, agricultural land productivity, and transportation networks), provide a comprehensive, meaningful, and integrated view of major elements involved in the urbanization/encroachment process.

Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards.

PubMed

Bottomley, Andrew; Pe, Madeline; Sloan, Jeff; Basch, Ethan; Bonnetain, Franck; Calvert, Melanie; Campbell, Alicyn; Cleeland, Charles; Cocks, Kim; Collette, Laurence; Dueck, Amylou C; Devlin, Nancy; Flechtner, Hans-Henning; Gotay, Carolyn; Greimel, Eva; Griebsch, Ingolf; Groenvold, Mogens; Hamel, Jean-Francois; King, Madeleine; Kluetz, Paul G; Koller, Michael; Malone, Daniel C; Martinelli, Francesca; Mitchell, Sandra A; Moinpour, Carol M; Musoro, Jammbe; O'Connor, Daniel; Oliver, Kathy; Piault-Louis, Elisabeth; Piccart, Martine; Pimentel, Francisco L; Quinten, Chantal; Reijneveld, Jaap C; Schürmann, Christoph; Smith, Ashley Wilder; Soltys, Katherine M; Taphoorn, Martin J B; Velikova, Galina; Coens, Corneel

2016-11-01

Measures of health-related quality of life (HRQOL) and other patient-reported outcomes generate important data in cancer randomised trials to assist in assessing the risks and benefits of cancer therapies and fostering patient-centred cancer care. However, the various ways these measures are analysed and interpreted make it difficult to compare results across trials, and hinders the application of research findings to inform publications, product labelling, clinical guidelines, and health policy. To address these problems, the Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data (SISAQOL) initiative has been established. This consortium, directed by the European Organisation for Research and Treatment of Cancer (EORTC), was convened to provide recommendations on how to standardise the analysis of HRQOL and other patient-reported outcomes data in cancer randomised trials. This Personal View discusses the reasons why this project was initiated, the rationale for the planned work, and the expected benefits to cancer research, patient and provider decision making, care delivery, and policy making. Copyright © 2016 Elsevier Ltd. All rights reserved.

Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.

PubMed

Rappaport, Noa; Fishilevich, Simon; Nudel, Ron; Twik, Michal; Belinky, Frida; Plaschkes, Inbar; Stein, Tsippi Iny; Cohen, Dana; Oz-Levi, Danit; Safran, Marilyn; Lancet, Doron

2017-08-18

A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses. VarElect, our NGS interpretation tool, leverages the broad information in the GeneCards suite databases. MalaCards algorithms unify disease-related terms and annotations from 69 sources. Further, MalaCards defines hierarchical relatedness-aliases, disease families, a related diseases network, categories and ontological classifications. GeneCards and MalaCards delineate and share a multi-tiered, scored gene-disease network, with stringency levels, including the definition of elite status-high quality gene-disease pairs, coming from manually curated trustworthy sources, that includes 4500 genes for 8000 diseases. This unique resource is key to NGS interpretation by VarElect. VarElect, a comprehensive search tool that helps infer both direct and indirect links between genes and user-supplied disease/phenotype terms, is robustly strengthened by the information found in MalaCards. The indirect mode benefits from GeneCards' diverse gene-to-gene relationships, including SuperPaths-integrated biological pathways from 12 information sources. We are currently adding an important information layer in the form of "disease SuperPaths", generated from the gene-disease matrix by an algorithm similar to that previously employed for biological pathway unification. This allows the discovery of novel gene-disease and disease-disease relationships. The advent of whole genome sequencing necessitates capacities to go beyond protein coding genes. GeneCards is highly useful in this respect, as it also addresses 101,976 non-protein-coding RNA genes. In a more recent development, we are currently adding an inclusive map of regulatory elements and their inferred target genes, generated by integration from 4 resources. MalaCards provides a rich big-data scaffold for in silico biomedical discovery within the gene-disease universe. VarElect, which depends significantly on both GeneCards and MalaCards power, is a potent tool for supporting the interpretation of wet-lab experiments, notably NGS analyses of disease. The GeneCards suite has thus transcended its 2-decade role in biomedical research, maturing into a key player in clinical investigation.

The Cross-cultural Utility of Foreign- and Locally-derived Normative Data for Three WHO-endorsed Neuropsychological Tests for South African Adolescents

PubMed Central

Ferrett, Helen L.; Thomas, Kevin G. F.; Tapert, Susan F.; Carey, Paul D.; Conradie, Simone; Cuzen, Natalie L.; Stein, Dan J.; Fein, George

2014-01-01

Interpretation of neuropsychological tests may be hampered by confounding sociodemographic factors and by using inappropriate normative data. We investigated these factors in three tests endorsed by the World Health Organization: the Grooved Pegboard Test (GPT), the Children's Color Trails Test (CCTT), and the WHO/UCLA version of the Auditory Verbal Learning Test (AVLT). In a sample of 12-15-year-old, Afrikaans- and English-speaking adolescents from the Cape Town region of South Africa, analyses of covariance (ANCOVAs) demonstrated that quality of education was the sociodemographic factor with the biggest influence on test performance, and that age also significantly influenced GPT and CCTT performance. Based on those findings, we provide appropriately stratified normative data for the age group in question. Comparisons between diagnostic interpretations made using foreign normative data versus those using the current local data demonstrate that it is imperative to use appropriately stratified normative data to guard against misinterpreting performance. PMID:24526566

Guidelines for Reporting Articles on Psychiatry and Heart rate variability (GRAPH): recommendations to advance research communication

PubMed Central

Quintana, D S; Alvares, G A; Heathers, J A J

2016-01-01

The number of publications investigating heart rate variability (HRV) in psychiatry and the behavioral sciences has increased markedly in the last decade. In addition to the significant debates surrounding ideal methods to collect and interpret measures of HRV, standardized reporting of methodology in this field is lacking. Commonly cited recommendations were designed well before recent calls to improve research communication and reproducibility across disciplines. In an effort to standardize reporting, we propose the Guidelines for Reporting Articles on Psychiatry and Heart rate variability (GRAPH), a checklist with four domains: participant selection, interbeat interval collection, data preparation and HRV calculation. This paper provides an overview of these four domains and why their standardized reporting is necessary to suitably evaluate HRV research in psychiatry and related disciplines. Adherence to these communication guidelines will help expedite the translation of HRV research into a potential psychiatric biomarker by improving interpretation, reproducibility and future meta-analyses. PMID:27163204

The arcsine is asinine: the analysis of proportions in ecology.

PubMed

Warton, David I; Hui, Francis K C

2011-01-01

The arcsine square root transformation has long been standard procedure when analyzing proportional data in ecology, with applications in data sets containing binomial and non-binomial response variables. Here, we argue that the arcsine transform should not be used in either circumstance. For binomial data, logistic regression has greater interpretability and higher power than analyses of transformed data. However, it is important to check the data for additional unexplained variation, i.e., overdispersion, and to account for it via the inclusion of random effects in the model if found. For non-binomial data, the arcsine transform is undesirable on the grounds of interpretability, and because it can produce nonsensical predictions. The logit transformation is proposed as an alternative approach to address these issues. Examples are presented in both cases to illustrate these advantages, comparing various methods of analyzing proportions including untransformed, arcsine- and logit-transformed linear models and logistic regression (with or without random effects). Simulations demonstrate that logistic regression usually provides a gain in power over other methods.

Internal models for interpreting neural population activity during sensorimotor control

PubMed Central

Golub, Matthew D; Yu, Byron M; Chase, Steven M

2015-01-01

To successfully guide limb movements, the brain takes in sensory information about the limb, internally tracks the state of the limb, and produces appropriate motor commands. It is widely believed that this process uses an internal model, which describes our prior beliefs about how the limb responds to motor commands. Here, we leveraged a brain-machine interface (BMI) paradigm in rhesus monkeys and novel statistical analyses of neural population activity to gain insight into moment-by-moment internal model computations. We discovered that a mismatch between subjects’ internal models and the actual BMI explains roughly 65% of movement errors, as well as long-standing deficiencies in BMI speed control. We then used the internal models to characterize how the neural population activity changes during BMI learning. More broadly, this work provides an approach for interpreting neural population activity in the context of how prior beliefs guide the transformation of sensory input to motor output. DOI: http://dx.doi.org/10.7554/eLife.10015.001 PMID:26646183

The cross-cultural utility of foreign- and locally-derived normative data for three WHO-endorsed neuropsychological tests for South African adolescents.

PubMed

Ferrett, Helen L; Thomas, Kevin G F; Tapert, Susan F; Carey, Paul D; Conradie, Simone; Cuzen, Natalie L; Stein, Dan J; Fein, George

2014-06-01

Interpretation of neuropsychological tests may be hampered by confounding sociodemographic factors and by using inappropriate normative data. We investigated these factors in three tests endorsed by the World Health Organization: the Grooved Pegboard Test (GPT), the Children's Color Trails Test (CCTT), and the WHO/UCLA version of the Auditory Verbal Learning Test (AVLT). In a sample of 12-15-year-old, Afrikaans- and English-speaking adolescents from the Cape Town region of South Africa, analyses of covariance (ANCOVAs) demonstrated that quality of education was the sociodemographic factor with the biggest influence on test performance, and that age also significantly influenced GPT and CCTT performance. Based on those findings, we provide appropriately stratified normative data for the age group in question. Comparisons between diagnostic interpretations made using foreign normative data versus those using the current local data demonstrate that it is imperative to use appropriately stratified normative data to guard against misinterpreting performance.

Challenges of ECG monitoring and ECG interpretation in dialysis units.

PubMed

Poulikakos, Dimitrios; Malik, Marek

Patients on hemodialysis (HD) suffer from high cardiovascular morbidity and mortality due to high rates of coronary artery disease and arrhythmias. Electrocardiography (ECG) is often performed in the dialysis units as part of routine clinical assessment. However, fluid and electrolyte changes have been shown to affect all ECG morphologies and intervals. ECG interpretation thus depends on the time of the recording in relation to the HD session. In addition, arrhythmias during HD are common, and dialysis-related ECG artifacts mimicking arrhythmias have been reported. Studies using advanced ECG analyses have examined the impact of the HD procedure on selected repolarization descriptors and heart rate variability indices. Despite the challenges related to the impact of the fluctuant fluid and electrolyte status on conventional and advanced ECG parameters, further research in ECG monitoring during dialysis has the potential to provide clinically meaningful and practically useful information for diagnostic and risk stratification purposes. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Partner aggression and problem drinking across the lifespan: how much do they decline?

PubMed

O'Leary, K Daniel; Woodin, Erica M

2005-11-01

Cross-sectional analyses from nationally-representative samples demonstrate significant age-related trends in partner aggression and problem drinking. Both behaviors are most prevalent in the early to mid-twenties and increasingly less common thereafter. Aggregate associations based on percentage of individuals displaying the behavior in each age range are dramatically stronger than those found when correlating individuals' ages and behavior. Multilevel modeling demonstrates that group-level effects do not mask associations found at the level of the individual for either problem drinking or partner aggression. An analysis of recent abstracts from psychology journals showed that issues of aggregate and individual data are rarely if ever discussed, and even well-known statistics books in psychology rarely discuss such issues. The interpretation of aggregate data will become increasing important as psychologists themselves, and in collaboration with epidemiologists and sociologists, have access to large data sets that allow for data aggregation. Both aggregate and individual analyses are valid, although they provide answers to different questions. Individual analyses are necessary for predicting individual behavior; aggregate analyses are useful in policy planning for large scale prevention and intervention. Strengths and limitations of cross-sectional community samples and aggregate data are also discussed.

A Transparent and Transferable Framework for Tracking Quality Information in Large Datasets

PubMed Central

Smith, Derek E.; Metzger, Stefan; Taylor, Jeffrey R.

2014-01-01

The ability to evaluate the validity of data is essential to any investigation, and manual “eyes on” assessments of data quality have dominated in the past. Yet, as the size of collected data continues to increase, so does the effort required to assess their quality. This challenge is of particular concern for networks that automate their data collection, and has resulted in the automation of many quality assurance and quality control analyses. Unfortunately, the interpretation of the resulting data quality flags can become quite challenging with large data sets. We have developed a framework to summarize data quality information and facilitate interpretation by the user. Our framework consists of first compiling data quality information and then presenting it through 2 separate mechanisms; a quality report and a quality summary. The quality report presents the results of specific quality analyses as they relate to individual observations, while the quality summary takes a spatial or temporal aggregate of each quality analysis and provides a summary of the results. Included in the quality summary is a final quality flag, which further condenses data quality information to assess whether a data product is valid or not. This framework has the added flexibility to allow “eyes on” information on data quality to be incorporated for many data types. Furthermore, this framework can aid problem tracking and resolution, should sensor or system malfunctions arise. PMID:25379884

Interpreting U-Pb data from primary and secondary features in lunar zircon

NASA Astrophysics Data System (ADS)

Grange, M. L.; Pidgeon, R. T.; Nemchin, A. A.; Timms, N. E.; Meyer, C.

2013-01-01

In this paper, we describe primary and secondary microstructures and textural characteristics found in lunar zircon and discuss the relationships between these features and the zircon U-Pb isotopic systems and the significance of these features for understanding lunar processes. Lunar zircons can be classified according to: (i) textural relationships between zircon and surrounding minerals in the host breccias, (ii) the internal microstructures of the zircon grains as identified by optical microscopy, cathodoluminescence (CL) imaging and electron backscattered diffraction (EBSD) mapping and (iii) results of in situ ion microprobe analyses of the Th-U-Pb isotopic systems. Primary zircon can occur as part of a cogenetic mineral assemblage (lithic clast) or as an individual mineral clast and is unzoned, or has sector and/or oscillatory zoning. The age of primary zircon is obtained when multiple ion microprobe analyses across the polished surface of the grain give reproducible and essentially concordant data. A secondary set of microstructures, superimposed on primary zircon, include localised recrystallised domains, localised amorphous domains, crystal-plastic deformation, planar deformation features and fractures, and are associated with impact processes. The first two secondary microstructures often yield internally consistent and close to concordant U-Pb ages that we interpret as dating impact events. Others secondary microstructures such as planar deformation features, crystal-plastic deformation and micro-fractures can provide channels for Pb diffusion and result in partial resetting of the U-Pb isotopic systems.

Sharing clinical trial data on patient level: Opportunities and challenges

PubMed Central

Koenig, Franz; Slattery, Jim; Groves, Trish; Lang, Thomas; Benjamini, Yoav; Day, Simon; Bauer, Peter; Posch, Martin

2015-01-01

In recent months one of the most controversially discussed topics among regulatory agencies, the pharmaceutical industry, journal editors, and academia has been the sharing of patient-level clinical trial data. Several projects have been started such as the European Medicines Agency´s (EMA) “proactive publication of clinical trial data”, the BMJ open data campaign, or the AllTrials initiative. The executive director of the EMA, Dr. Guido Rasi, has recently announced that clinical trial data on patient level will be published from 2014 onwards (although it has since been delayed). The EMA draft policy on proactive access to clinical trial data was published at the end of June 2013 and open for public consultation until the end of September 2013. These initiatives will change the landscape of drug development and publication of medical research. They provide unprecedented opportunities for research and research synthesis, but pose new challenges for regulatory authorities, sponsors, scientific journals, and the public. Besides these general aspects, data sharing also entails intricate biostatistical questions such as problems of multiplicity. An important issue in this respect is the interpretation of multiple statistical analyses, both prospective and retrospective. Expertise in biostatistics is needed to assess the interpretation of such multiple analyses, for example, in the context of regulatory decision-making by optimizing procedural guidance and sophisticated analysis methods. PMID:24942505

Mendelian randomization analyses in cardiometabolic disease: challenges in evaluating causality

PubMed Central

Holmes, Michael V; Ala-Korpela, Mika; Davey Smith, George

2017-01-01

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentrations can help to assess their causal role in disease. However, a more complex relationship between the genetic variants and an exposure can make findings from MR more difficult to interpret. In this Review, we describe some of these challenges in interpreting MR analyses, including those from studies using genetic variants to assess causality of multiple traits (such as branched-chain amino acids and risk of diabetes mellitus); studies describing pleiotropic variants (for example, C-reactive protein and its contribution to coronary heart disease); and those investigating variants that disrupt normal function of an exposure (for example, HDL cholesterol or IL-6 and coronary heart disease). Furthermore, MR studies on variants that encode enzymes responsible for the metabolism of an exposure (such as alcohol) are discussed, in addition to those assessing the effects of variants on time-dependent exposures (extracellular superoxide dismutase), cumulative exposures (LDL cholesterol), and overlapping exposures (triglycerides and non-HDL cholesterol). We elaborate on the molecular features of each relationship, and provide explanations for the likely causal associations. In doing so, we hope to contribute towards more reliable evaluations of MR findings. PMID:28569269

Social Information Processing Mechanisms and Victimization: A Literature Review.

PubMed

van Reemst, Lisa; Fischer, Tamar F C; Zwirs, Barbara W C

2016-01-01

The aim of the current literature review, which is based on 64 empirical studies, was to assess to what extent mechanisms of the Social Information Processing (SIP) model of Crick and Dodge (1994) are related to victimization. The reviewed studies have provided support for the relation between victimization and several social information processing mechanisms, especially the interpretation of cues and self-efficacy (as part of the response decision). The relationship between victimization and other mechanisms, such as the response generation, was only studied in a few articles. Until now research has often focused on just one step of the model, instead of attempting to measure the associations between multiple mechanisms and victimization in multivariate analyses. Such analyses would be interesting to gain more insight into the SIP model and its relationship with victimization. The few available longitudinal studies show that mechanisms both predict victimization (internal locus of control, negative self-evaluations and less assertive response selection) and are predicted by victimization (hostile attribution of intent and negative evaluations of others). Associations between victimization and SIP mechanisms vary across different types and severity of victimization (stronger in personal and severe victimization), and different populations (stronger among young victims). Practice could focus on these stronger associations and the interpretation of cues. More research is needed however, to investigate whether intervention programs that address SIP mechanisms are suitable for victimization and all relevant populations. © The Author(s) 2014.

Mars Infrared Spectroscopy: From Theory and the Laboratory To Field Observations

NASA Technical Reports Server (NTRS)

Kirkland, Laurel (Editor); Mustard, John (Editor); McAfee, John (Editor); Hapke, Bruce (Editor); Ramsey, Michael (Editor)

2002-01-01

The continuity and timely implementation of the Mars exploration strategy relies heavily on the ability of the planetary community to interpret infrared spectral data. However, the increasing mission rate, data volume, and data variety, combined with the small number of spectroscopists within the planetary community, will require a coordinated community effort for effective and timely interpretation of the newly acquired and planned data sets. Relevant spectroscopic instruments include the 1996 TES, 2001 THEMIS, 2003 Pancam, 2003 Mini-TES, 2003 Mars Express OMEGA, 2003 Mars Express PFS, and 2005 CFUSM. In light of that, leaders of the Mars spectral community met June 4-6 to address the question: What terrestrial theoretical, laboratory, and field studies are most needed to best support timely interpretations of current and planned visible infrared spectrometer data sets, in light of the Mars Program goals? A primary goal of the spectral community is to provide a reservoir of information to enhance and expand the exploration of Mars. Spectroscopy has a long history of providing the fundamental compositional discoveries in the solar system, from atmospheric constituents to surface mineralogy, from earth-based to spacecraft-based observations. However, such spectroscopic compositional discoveries, especially surface mineralogies, have usually come after long periods of detailed integration of remote observations, laboratory analyses, and field measurements. Spectroscopic information of surfaces is particularly complex and often is confounded by interference of broad, overlapping absorption features as well as confusing issues of mixtures, coatings, and grain size effects. Thus some spectroscopic compositional discoveries have come only after many years of research. However, we are entering an era of Mars exploration with missions carrying sophisticated spectrometers launching about every 2 years. It is critical that each mission provide answers to relevant questions to optimize the success of the next mission. That will not occur effectively unless the spectroscopic remote sensing data can be processed and understood on an approximate 2-year rate. Our current knowledge of spectral properties of materials and confounding effects of the natural environment are note well enough understood for the accurate interpretations needed for such ambitious and time critical exploration objectives. This workshop focused on identify ing critical gaps in moving the field towards the goal of rapid and accurate analysis and interpretation.

Vertical or horizontal orientation of foot radiographs does not affect image interpretation

PubMed Central

Ferran, Nicholas Antonio; Ball, Luke; Maffulli, Nicola

2012-01-01

Summary This study determined whether the orientation of dorsoplantar and oblique foot radiographs has an effect on radiograph interpretation. A test set of 50 consecutive foot radiographs were selected (25 with fractures, and 25 normal), and duplicated in the horizontal orientation. The images were randomly arranged, numbered 1 through 100, and analysed by six image interpreters. Vertical and horizontal area under the ROC curve, accuracy, sensitivity and specificity were calculated for each image interpreter. There was no significant difference in the area under the ROC curve, accuracy, sensitivity or specificity of image interpretation between images viewed in the vertical or horizontal orientation. While conventions for display of radiographs may help to improve the development of an efficient visual search strategy in trainees, and allow for standardisation of publication of radiographic images, variation from the convention in clinical practice does not appear to affect the sensitivity or specificity of image interpretation. PMID:23738310

Don't panic: interpretation bias is predictive of new onsets of panic disorder.

PubMed

Woud, Marcella L; Zhang, Xiao Chi; Becker, Eni S; McNally, Richard J; Margraf, Jürgen

2014-01-01

Psychological models of panic disorder postulate that interpretation of ambiguous material as threatening is an important maintaining factor for the disorder. However, demonstrations of whether such a bias predicts onset of panic disorder are missing. In the present study, we used data from the Dresden Prediction Study, in which a epidemiologic sample of young German women was tested at two time points approximately 17 months apart, allowing the study of biased interpretation as a potential risk factor. At time point one, participants completed an Interpretation Questionnaire including two types of ambiguous scenarios: panic-related and general threat-related. Analyses revealed that a panic-related interpretation bias predicted onset of panic disorder, even after controlling for two established risk factors: anxiety sensitivity and fear of bodily sensations. This is the first prospective study demonstrating the incremental validity of interpretation bias as a predictor of panic disorder onset. Copyright © 2013 Elsevier Ltd. All rights reserved.

US forests are showing increased rates of decline in response to a changing climate

Treesearch

Warren B. Cohen; Zhiqiang Yang; David M. Bell; Stephen V. Stehman

2015-01-01

How vulnerable are US forest to a changing climate? We answer this question using Landsat time series data and a unique interpretation approach, TimeSync, a plot-based Landsat visualization and data collection tool. Original analyses were based on a stratified two-stage cluster sample design that included interpretation of 3858 forested plots. From these data, we...

Examining the Impact of Unscorable Item Responses on the Validity and Interpretability of MMPI-2/MMPI-2-RF Restructured Clinical (RC) Scale Scores

ERIC Educational Resources Information Center

Dragon, Wendy R.; Ben-Porath, Yossef S.; Handel, Richard W.

2012-01-01

This article examined the impact of unscorable item responses on the psychometric validity and practical interpretability of scores on the Restructured Clinical (RC) Scales of the Minnesota Multiphasic Personality Inventory-2/Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2/MMPI-2-RF). In analyses conducted with five…

Why Education Practitioners and Stakeholders Should Care about Person Fit in Educational Assessments

ERIC Educational Resources Information Center

Walker, A. Adrienne

2017-01-01

In this article, A. Adrienne Walker introduces the concept of person fit to education stakeholders as a source of evidence to inform the trustworthiness of a test score for interpretation and use (validity). Person fit analyses are used in educational measurement research to explore the degree to which a person's test score can be interpreted as a…

Analysing magnetism using scanning SQUID microscopy.

PubMed

Reith, P; Renshaw Wang, X; Hilgenkamp, H

2017-12-01

Scanning superconducting quantum interference device microscopy (SSM) is a scanning probe technique that images local magnetic flux, which allows for mapping of magnetic fields with high field and spatial accuracy. Many studies involving SSM have been published in the last few decades, using SSM to make qualitative statements about magnetism. However, quantitative analysis using SSM has received less attention. In this work, we discuss several aspects of interpreting SSM images and methods to improve quantitative analysis. First, we analyse the spatial resolution and how it depends on several factors. Second, we discuss the analysis of SSM scans and the information obtained from the SSM data. Using simulations, we show how signals evolve as a function of changing scan height, SQUID loop size, magnetization strength, and orientation. We also investigated 2-dimensional autocorrelation analysis to extract information about the size, shape, and symmetry of magnetic features. Finally, we provide an outlook on possible future applications and improvements.

Analysing magnetism using scanning SQUID microscopy

NASA Astrophysics Data System (ADS)

Reith, P.; Renshaw Wang, X.; Hilgenkamp, H.

2017-12-01

Scanning superconducting quantum interference device microscopy (SSM) is a scanning probe technique that images local magnetic flux, which allows for mapping of magnetic fields with high field and spatial accuracy. Many studies involving SSM have been published in the last few decades, using SSM to make qualitative statements about magnetism. However, quantitative analysis using SSM has received less attention. In this work, we discuss several aspects of interpreting SSM images and methods to improve quantitative analysis. First, we analyse the spatial resolution and how it depends on several factors. Second, we discuss the analysis of SSM scans and the information obtained from the SSM data. Using simulations, we show how signals evolve as a function of changing scan height, SQUID loop size, magnetization strength, and orientation. We also investigated 2-dimensional autocorrelation analysis to extract information about the size, shape, and symmetry of magnetic features. Finally, we provide an outlook on possible future applications and improvements.

Association between periodontal disease and dementia: A literature review.

PubMed

Pazos, P; Leira, Y; Domínguez, C; Pías-Peleteiro, J M; Blanco, J; Aldrey, J M

2016-10-22

Periodontal disease and dementia are very prevalent, especially in elderly populations. Multiple studies have shown a link between these diseases; however, the conditions are highly heterogeneous and so is the diagnostic methodology, which may hinder interpretation and comparison of the results. The aim of this article is to provide a critical review of the literature linking these 2 processes. We retrieved 22 studies, most of which were retrospective, and analysed various methodological variables including study population, diagnosis of periodontitis, definition of dementia, adjusted variables, and results. The different aetiopathogenic mechanisms that may affect the progression and interaction of these 2 conditions were also analysed. Although available evidence indicates a positive association between periodontitis and dementia, both the strength of that association and the presence of a causal relationship have yet to be determined. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Educational action research on Facebook®: combining leisure and learning.

PubMed

Labegalini, Célia Maria Gomes; Nogueira, Iara Sescon; Rodrigues, Daysi Mara Murio Ribeiro; Almeida, Elton Carlos; Bueno, Sonia Maria Villela; Baldissera, Vanessa Denardi Antoniassi

2017-04-06

To analyse the path of dialogical education in leisure and mental health in social media. Action research based on the theoretical-methodological framework of Paulo Freire, conducted with 11 nursing students of a public university in the state of Paraná, Brazil, during seven days of June 2015, in a closed group on Facebook®. The dialogues were called, 'Virtual Culture Circles' and preceded by self-administered questionnaires that addressed the relationship between leisure and mental health. The data were analysed in an interpretive way, using the encoding and decoding proposed by Freire. The students related leisure to pleasurable activities and quality of life; however, it is not widely or critically practiced in their personal lives or education. The Virtual Culture Circles provided emancipatory dialogues and a critical analysis of the subject matter, with possible repercussions on the personal and professional lives of the subjects.

Gaining insights from social media language: Methodologies and challenges.

PubMed

Kern, Margaret L; Park, Gregory; Eichstaedt, Johannes C; Schwartz, H Andrew; Sap, Maarten; Smith, Laura K; Ungar, Lyle H

2016-12-01

Language data available through social media provide opportunities to study people at an unprecedented scale. However, little guidance is available to psychologists who want to enter this area of research. Drawing on tools and techniques developed in natural language processing, we first introduce psychologists to social media language research, identifying descriptive and predictive analyses that language data allow. Second, we describe how raw language data can be accessed and quantified for inclusion in subsequent analyses, exploring personality as expressed on Facebook to illustrate. Third, we highlight challenges and issues to be considered, including accessing and processing the data, interpreting effects, and ethical issues. Social media has become a valuable part of social life, and there is much we can learn by bringing together the tools of computer science with the theories and insights of psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Proteogenomic characterization of human colon and rectal cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Bing; Wang, Jing; Wang, Xiaojing

2014-09-18

We analyzed proteomes of colon and rectal tumors previously characterized by the Cancer Genome Atlas (TCGA) and performed integrated proteogenomic analyses. Protein sequence variants encoded by somatic genomic variations displayed reduced expression compared to protein variants encoded by germline variations. mRNA transcript abundance did not reliably predict protein expression differences between tumors. Proteomics identified five protein expression subtypes, two of which were associated with the TCGA "MSI/CIMP" transcriptional subtype, but had distinct mutation and methylation patterns and associated with different clinical outcomes. Although CNAs showed strong cis- and trans-effects on mRNA expression, relatively few of these extend to the proteinmore » level. Thus, proteomics data enabled prioritization of candidate driver genes. Our analyses identified HNF4A, a novel candidate driver gene in tumors with chromosome 20q amplifications. Integrated proteogenomic analysis provides functional context to interpret genomic abnormalities and affords novel insights into cancer biology.« less

Revealing the hidden language of complex networks.

PubMed

Yaveroğlu, Ömer Nebil; Malod-Dognin, Noël; Davis, Darren; Levnajic, Zoran; Janjic, Vuk; Karapandza, Rasa; Stojmirovic, Aleksandar; Pržulj, Nataša

2014-04-01

Sophisticated methods for analysing complex networks promise to be of great benefit to almost all scientific disciplines, yet they elude us. In this work, we make fundamental methodological advances to rectify this. We discover that the interaction between a small number of roles, played by nodes in a network, can characterize a network's structure and also provide a clear real-world interpretation. Given this insight, we develop a framework for analysing and comparing networks, which outperforms all existing ones. We demonstrate its strength by uncovering novel relationships between seemingly unrelated networks, such as Facebook, metabolic, and protein structure networks. We also use it to track the dynamics of the world trade network, showing that a country's role of a broker between non-trading countries indicates economic prosperity, whereas peripheral roles are associated with poverty. This result, though intuitive, has escaped all existing frameworks. Finally, our approach translates network topology into everyday language, bringing network analysis closer to domain scientists.

What Can the Diffusion Model Tell Us About Prospective Memory?

PubMed Central

Horn, Sebastian S.; Bayen, Ute J.; Smith, Rebekah E.

2011-01-01

Cognitive process models, such as Ratcliff’s (1978) diffusion model, are useful tools for examining cost- or interference effects in event-based prospective memory (PM). The diffusion model includes several parameters that provide insight into how and why ongoing-task performance may be affected by a PM task and is ideally suited to analyze performance because both reaction time and accuracy are taken into account. Separate analyses of these measures can easily yield misleading interpretations in cases of speed-accuracy tradeoffs. The diffusion model allows us to measure possible criterion shifts and is thus an important methodological improvement over standard analyses. Performance in an ongoing lexical decision task (Smith, 2003) was analyzed with the diffusion model. The results suggest that criterion shifts play an important role when a PM task is added, but do not fully explain the cost effect on RT. PMID:21443332

Deaf college students' attitudes toward racial/ethnic diversity, campus climate, and role models.

PubMed

Parasnis, Ila; Samar, Vincent J; Fischer, Susan D

2005-01-01

Deaf college students' attitudes toward a variety of issues related to racial/ethnic diversity were surveyed by contacting all racial/ethnic minority deaf students and a random sample of Caucasian deaf students attending the National Technical Institute for the Deaf (NTID), Rochester Institute of Technology; 38% completed the survey. Although racial/ethnic groups similarly perceived NTID's commitment and efforts related to diversity, they differed significantly on some items related to campus climate and role models. Furthermore, the racial/ethnic minority groups differed from each other in their perceptions of campus comfort level, racial conflict, friendship patterns, and availability of role models. Educational satisfaction was positively correlated with campus comfort level; both correlated negatively with perception of discrimination and racial conflict. Qualitative data analyses supported quantitative data analyses and provided rich detail that facilitated interpretation of deaf students' experiences related to racial/ethnic diversity.

Building a Data Science capability for USGS water research and communication

NASA Astrophysics Data System (ADS)

Appling, A.; Read, E. K.

2015-12-01

Interpreting and communicating water issues in an era of exponentially increasing information requires a blend of domain expertise, computational proficiency, and communication skills. The USGS Office of Water Information has established a Data Science team to meet these needs, providing challenging careers for diverse domain scientists and innovators in the fields of information technology and data visualization. Here, we detail the experience of building a Data Science capability as a bridging element between traditional water resources analyses and modern computing tools and data management techniques. This approach includes four major components: 1) building reusable research tools, 2) documenting data-intensive research approaches in peer reviewed journals, 3) communicating complex water resources issues with interactive web visualizations, and 4) offering training programs for our peers in scientific computing. These components collectively improve the efficiency, transparency, and reproducibility of USGS data analyses and scientific workflows.

Ion Irradiation Experiments on the Murchison CM2 Carbonaceous Chondrite: Simulating Space Weathering of Primitive Asteroids

NASA Technical Reports Server (NTRS)

Keller, L. P.; Christoffersen, R.; Dukes, C. A.; Baragiola, R. A.; Rahman, Z.

2015-01-01

Remote sensing observations show that space weathering processes affect all airless bodies in the Solar System to some degree. Sample analyses and lab experiments provide insights into the chemical, spectroscopic and mineralogic effects of space weathering and aid in the interpretation of remote- sensing data. For example, analyses of particles returned from the S-type asteroid Itokawa by the Hayabusa mission revealed that space-weathering on that body was dominated by interactions with the solar wind acting on LL ordinary chondrite-like materials [1, 2]. Understanding and predicting how the surface regoliths of primitive carbonaceous asteroids respond to space weathering processes is important for future sample return missions (Hayabusa 2 and OSIRIS-REx) that are targeting objects of this type. Here, we report the results of our preliminary ion irradiation experiments on a hydrated carbonaceous chondrite with emphasis on microstructural and infrared spectral changes.

Toward Establishing the Validity of the Resource Interpreter's Self-Efficacy Instrument

NASA Astrophysics Data System (ADS)

Smith, Grant D.

Interpretive rangers serve as one of the major educational resources that visitors may encounter during their visit to a park or other natural area, yet our understanding of their professional growth remains limited. This study helps address this issue by developing an instrument that evaluates the beliefs of resource interpreters regarding their capabilities of communicating with the public. The resulting 11-item instrument was built around the construct of Albert Bandura's self-efficacy theory (Bandura, 1977, 1986, 1997), used guidelines and principles developed over the course of 30 years of teacher efficacy studies (Bandura, 2006; Gibson & Dembo, 1984; Riggs & Enochs, 1990; Tschannen-Moran & Hoy, 2001; Tschannen-Moran, Hoy, & Hoy, 1998), and probed areas of challenge that are unique to the demands of resource interpretation (Brochu & Merriman, 2002; Ham, 1992; Knudson, Cable, & Beck, 2003; Larsen, 2003; Tilden, 1977). A voluntary convenience sample of 364 National Park Service rangers was collected in order to conduct the statistical analyses needed to winnow the draft instrument down from 47 items in its original form to 11 items in its final state. Statistical analyses used in this process included item-total correlation, index of discrimination, exploratory factor analysis, and confirmatory factor analysis.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants

PubMed Central

Reuter, Miriam S.; Walker, Susan; Thiruvahindrapuram, Bhooma; Whitney, Joe; Cohn, Iris; Sondheimer, Neal; Yuen, Ryan K.C.; Trost, Brett; Paton, Tara A.; Pereira, Sergio L.; Herbrick, Jo-Anne; Wintle, Richard F.; Merico, Daniele; Howe, Jennifer; MacDonald, Jeffrey R.; Lu, Chao; Nalpathamkalam, Thomas; Sung, Wilson W.L.; Wang, Zhuozhi; Patel, Rohan V.; Pellecchia, Giovanna; Wei, John; Strug, Lisa J.; Bell, Sherilyn; Kellam, Barbara; Mahtani, Melanie M.; Bassett, Anne S.; Bombard, Yvonne; Weksberg, Rosanna; Shuman, Cheryl; Cohn, Ronald D.; Stavropoulos, Dimitri J.; Bowdin, Sarah; Hildebrandt, Matthew R.; Wei, Wei; Romm, Asli; Pasceri, Peter; Ellis, James; Ray, Peter; Meyn, M. Stephen; Monfared, Nasim; Hosseini, S. Mohsen; Joseph-George, Ann M.; Keeley, Fred W.; Cook, Ryan A.; Fiume, Marc; Lee, Hin C.; Marshall, Christian R.; Davies, Jill; Hazell, Allison; Buchanan, Janet A.; Szego, Michael J.; Scherer, Stephen W.

2018-01-01

BACKGROUND: The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. METHODS: Volunteers were screened for eligibility and provided informed consent for open data sharing. Using blood DNA, we performed whole genome sequencing and identified all possible classes of DNA variants. A genetic counsellor explained the implication of the results to each participant. RESULTS: Whole genome sequencing of the first 56 participants identified 207 662 805 sequence variants and 27 494 copy number variations. We analyzed a prioritized disease-associated data set (n = 1606 variants) according to standardized guidelines, and interpreted 19 variants in 14 participants (25%) as having obvious health implications. Six of these variants (e.g., in BRCA1 or mosaic loss of an X chromosome) were pathogenic or likely pathogenic. Seven were risk factors for cancer, cardiovascular or neurobehavioural conditions. Four other variants — associated with cancer, cardiac or neurodegenerative phenotypes — remained of uncertain significance because of discrepancies among databases. We also identified a large structural chromosome aberration and a likely pathogenic mitochondrial variant. There were 172 recessive disease alleles (e.g., 5 individuals carried mutations for cystic fibrosis). Pharmacogenomics analyses revealed another 3.9 potentially relevant genotypes per individual. INTERPRETATION: Our analyses identified a spectrum of genetic variants with potential health impact in 25% of participants. When also considering recessive alleles and variants with potential pharmacologic relevance, all 56 participants had medically relevant findings. Although access is mostly limited to research, whole genome sequencing can provide specific and novel information with the potential of major impact for health care. PMID:29431110

A formal approach to the analysis of clinical computer-interpretable guideline modeling languages.

PubMed

Grando, M Adela; Glasspool, David; Fox, John

2012-01-01

To develop proof strategies to formally study the expressiveness of workflow-based languages, and to investigate their applicability to clinical computer-interpretable guideline (CIG) modeling languages. We propose two strategies for studying the expressiveness of workflow-based languages based on a standard set of workflow patterns expressed as Petri nets (PNs) and notions of congruence and bisimilarity from process calculus. Proof that a PN-based pattern P can be expressed in a language L can be carried out semi-automatically. Proof that a language L cannot provide the behavior specified by a PNP requires proof by exhaustion based on analysis of cases and cannot be performed automatically. The proof strategies are generic but we exemplify their use with a particular CIG modeling language, PROforma. To illustrate the method we evaluate the expressiveness of PROforma against three standard workflow patterns and compare our results with a previous similar but informal comparison. We show that the two proof strategies are effective in evaluating a CIG modeling language against standard workflow patterns. We find that using the proposed formal techniques we obtain different results to a comparable previously published but less formal study. We discuss the utility of these analyses as the basis for principled extensions to CIG modeling languages. Additionally we explain how the same proof strategies can be reused to prove the satisfaction of patterns expressed in the declarative language CIGDec. The proof strategies we propose are useful tools for analysing the expressiveness of CIG modeling languages. This study provides good evidence of the benefits of applying formal methods of proof over semi-formal ones. Copyright © 2011 Elsevier B.V. All rights reserved.

Overcoming Language Barriers in Health Care: Costs and Benefits of Interpreter Services

PubMed Central

Jacobs, Elizabeth A.; Shepard, Donald S.; Suaya, Jose A.; Stone, Esta-Lee

2004-01-01

Objectives. We assessed the impact of interpreter services on the cost and the utilization of health care services among patients with limited English proficiency. Methods. We measured the change in delivery and cost of care provided to patients enrolled in a health maintenance organization before and after interpreter services were implemented. Results. Compared with English-speaking patients, patients who used the interpreter services received significantly more recommended preventive services, made more office visits, and had more prescriptions written and filled. The estimated cost of providing interpreter services was $279 per person per year. Conclusions. Providing interpreter services is a financially viable method for enhancing delivery of health care to patients with limited English proficiency. PMID:15117713

Exploration of Heterogeneity in Distributed Research Network Drug Safety Analyses

ERIC Educational Resources Information Center

Hansen, Richard A.; Zeng, Peng; Ryan, Patrick; Gao, Juan; Sonawane, Kalyani; Teeter, Benjamin; Westrich, Kimberly; Dubois, Robert W.

2014-01-01

Distributed data networks representing large diverse populations are an expanding focus of drug safety research. However, interpreting results is difficult when treatment effect estimates vary across datasets (i.e., heterogeneity). In a previous study, risk estimates were generated for selected drugs and potential adverse outcomes. Analyses were…

The utility of atmospheric analyses for the mitigation of artifacts in InSAR

USGS Publications Warehouse

Foster, James; Kealy, John; Cherubini, Tiziana; Businger, S.; Lu, Zhong; Murphy, Michael

2013-01-01

The numerical weather models (NWMs) developed by the meteorological community are able to provide accurate analyses of the current state of the atmosphere in addition to the predictions of the future state. To date, most attempts to apply the NWMs to estimate the refractivity of the atmosphere at the time of satellite synthetic aperture radar (SAR) data acquisitions have relied on predictive models. We test the hypothesis that performing a final assimilative routine, ingesting all available meteorological observations for the times of SAR acquisitions, and generating customized analyses of the atmosphere at those times will better mitigate atmospheric artifacts in differential interferograms. We find that, for our study area around Mount St. Helens (Amboy, Washington, USA), this approach is unable to model the refractive changes and provides no mean benefit for interferogram analysis. The performance is improved slightly by ingesting atmospheric delay estimates derived from the limited local GPS network; however, the addition of water vapor products from the GOES satellites reduces the quality of the corrections. We interpret our results to indicate that, even with this advanced approach, NWMs are not a reliable mitigation technique for regions such as Mount St. Helens with highly variable moisture fields and complex topography and atmospheric dynamics. It is possible, however, that the addition of more spatially dense meteorological data to constrain the analyses might significantly improve the performance of weather modeling of atmospheric artifacts in satellite radar interferograms.

Bringing organic carbon isotopes and phytoliths to the table as additional constraints on paleoelevation

NASA Astrophysics Data System (ADS)

Sheldon, N. D.; Cotton, J. M.; Hren, M. T.; Hyland, E. G.; Smith, S. Y.; Strömberg, C. A. E.

2015-12-01

A commonly used tool in paleotectonic and paleoaltimetry studies is the oxygen isotopic composition of authigenic carbonates formed that formed in lakes or soils, with both spatial (e.g., shoreline to mountain top) or temporally resolved records potentially providing constraints. However, in many cases there is a substantial spread in the oxygen isotope data for a given time period, often to the point of allowing for essentially any interpretation of the data depending upon how they have been used by the investigator. One potential way of distinguishing between different potential paleotectonic or paleoaltimetric interpretations is to use carbon isotope and plant microfossil (phytolith) analyses from the same paleosols to screen the oxygen isotope data by looking for evidence of evaporative enrichment. For example, if both inorganic (carbonate) and organic carbon isotopes are measured from the same paleosol, then in it possible to determine if the two isotope record equilibrium conditions or if they record disequilibrium driven by kinetic effects. In the former case, the oxygen isotope results can be considered reliable whereas in the latter case, the oxygen isotope results can be considered unreliable and could be culled from the interpretation. Similarly, because the distribution of C4 plants varies as a function of temperature and elevation, the presence/absence or abundance of C4 plant phytoliths, or of carbon isotope compositions that require a component of C4 vegetation can also be used to constrain paleoelevation by providing a maximum elevation constraint. Worked examples will include the late Miocene-Pliocene of Catamarca, Argentina, where phytoliths and organic carbon isotopes provide a maximum elevation constraint and can be used to demonstrate that oxygen isotopes do not provide a locally useful constraint on paleoelevation, and Eocene-Miocene of southwestern Montana where organic matter and phytoliths can be used to select between different potential uplift histories as indicated by pedogenic carbonate oxygen isotope data.

Aging in deep gray matter and white matter revealed by diffusional kurtosis imaging.

PubMed

Gong, Nan-Jie; Wong, Chun-Sing; Chan, Chun-Chung; Leung, Lam-Ming; Chu, Yiu-Ching

2014-10-01

Diffusion tensor imaging has already been extensively used to probe microstructural alterations in white matter tracts, and scarcely, in deep gray matter. However, results in literature regarding age-related degenerative mechanisms in white matter tracts and parametric changes in the putamen are inconsistent. Diffusional kurtosis imaging is a mathematical extension of diffusion tensor imaging, which could more comprehensively mirror microstructure, particularly in isotropic tissues such as gray matter. In this study, we used the diffusional kurtosis imaging method and a white-matter model that provided metrics of explicit neurobiological interpretations in healthy participants (58 in total, aged from 25 to 84 years). Tract-based whole-brain analyses and regions-of-interest (anterior and posterior limbs of the internal capsule, cerebral peduncle, fornix, genu and splenium of corpus callosum, globus pallidus, substantia nigra, red nucleus, putamen, caudate nucleus, and thalamus) analyses were performed to examine parametric differences across regions and correlations with age. In white matter tracts, evidence was found supportive for anterior-posterior gradient and not completely supportive for retrogenesis theory. Age-related degenerations appeared to be broadly driven by axonal loss. Demyelination may also be a major driving mechanism, although confined to the anterior brain. In terms of deep gray matter, higher mean kurtosis and fractional anisotropy in the globus pallidus, substantia nigra, and red nucleus reflected higher microstructural complexity and directionality compared with the putamen, caudate nucleus, and thalamus. In particular, the unique age-related positive correlations for fractional anisotropy, mean kurtosis, and radial kurtosis in the putamen opposite to those in other regions call for further investigation of exact underlying mechanisms. In summary, the results suggested that diffusional kurtosis can provide measurements in a new dimension that were complementary to diffusivity metrics. Kurtosis together with diffusivity can more comprehensively characterize microstructural compositions and age-related changes than diffusivity alone. Combined with proper model, it may also assist in providing neurobiological interpretations of the identified alterations. Copyright © 2014 Elsevier Inc. All rights reserved.

From vulnerability to passion in the end-of-life care: The lived experience of nurses.

PubMed

Liu, Ying-Chun; Chiang, Hsien-Hsien

2017-12-01

End-of-life (EOL) care is considered to be inherently difficult and vulnerable for patients and nurses. It also seems hard to develop passion for care during these problematic times. This study elucidates how EOL nurses interpret their care experience and how they transform their experience and mindset. This study was conducted by organizing a reflective group based on the concept of group analysis for oncology and hospice nurses to share their experience. Thirteen registered nurses were enrolled from a medical center in northern Taiwan. Data drawn from the group dialogue was derived from six digitally recorded sessions and then analysed alone with the researcher's diaries and participants' feedback sheets. Interpretative Phenomenological Analysis (IPA) was used to analyze the data. The results showed that nurses who provide EOL care actually experience suffering by witnessing patients' suffering. However, the suffering authentically drives the nurses to encounter their own inner selves, to induce the shift of mindset, and then allow them to continuously provide and maintain the passion in EOL care. This study provides a new viewpoint for understanding of EOL nurses' experiences, indicating that this line of work may be recognized as a privilege. We recommend that the setting of a nurse reflective group is important and it may be considered in providing EOL care training for nurses. Hopefully the study results could shed lights for future policies regarding EOL care. Copyright © 2017 Elsevier Ltd. All rights reserved.

Access to hospital interpreter services for limited English proficient patients in New Jersey: a statewide evaluation.

PubMed

Flores, Glenn; Torres, Sylvia; Holmes, Linda Janet; Salas-Lopez, Debbie; Youdelman, Mara K; Tomany-Korman, Sandra C

2008-05-01

We surveyed New Jersey (NJ) hospitals to assess current language services and identify policy recommendations on meeting limited English proficiency (LEP) patients' needs. Survey with 37 questions regarding hospital/patient features, interpreter services, and resources/policies needed to provide quality interpreter services. Sixty-seven hospitals responded (55% response rate). Most NJ hospitals have no interpreter services department, 80% provide no staff training on working with interpreters, 31% lack multilingual signs, and 19% offer no written translation services. Only 3% of hospitals have full-time interpreters, a ratio of 1 interpreter:240,748 LEP NJ residents. Most hospitals stated third-party reimbursement for interpreters would be beneficial, by reducing costs, adding interpreters, meeting population growth, and improving communication. Most NJ hospitals have no full-time interpreters, interpreter services department, or staff training on working with interpreters, and deficiencies exist in hospital signage and translation services. Most NJ hospitals stated third-party reimbursement for interpreter services would be beneficial.

Man versus machine: comparison of radiologists' interpretations and NeuroQuant® volumetric analyses of brain MRIs in patients with traumatic brain injury.

PubMed

Ross, David E; Ochs, Alfred L; Seabaugh, Jan M; Shrader, Carole R

2013-01-01

NeuroQuant® is a recently developed, FDA-approved software program for measuring brain MRI volume in clinical settings. The purpose of this study was to compare NeuroQuant with the radiologist's traditional approach, based on visual inspection, in 20 outpatients with mild or moderate traumatic brain injury (TBI). Each MRI was analyzed with NeuroQuant, and the resulting volumetric analyses were compared with the attending radiologist's interpretation. The radiologist's traditional approach found atrophy in 10.0% of patients; NeuroQuant found atrophy in 50.0% of patients. NeuroQuant was more sensitive for detecting brain atrophy than the traditional radiologist's approach.

Court Interpretation: The Need for a Certification Process.

ERIC Educational Resources Information Center

Barnwell, David

A discussion of the role of court interpreters looks at the need for competent interpreters, the kinds and demands of court interpretation, and New Jersey's leadership in recognizing the necessity for court interpretation. Demographic and legal reasons for providing interpreters in today's courts are outlined. Three court interpreting functions…

Laboratory longitudinal diffusion tests: 1. Dimensionless formulations and validity of simplified solutions

NASA Astrophysics Data System (ADS)

Takeda, M.; Nakajima, H.; Zhang, M.; Hiratsuka, T.

2008-04-01

To obtain reliable diffusion parameters for diffusion testing, multiple experiments should not only be cross-checked but the internal consistency of each experiment should also be verified. In the through- and in-diffusion tests with solution reservoirs, test interpretation of different phases often makes use of simplified analytical solutions. This study explores the feasibility of steady, quasi-steady, equilibrium and transient-state analyses using simplified analytical solutions with respect to (i) valid conditions for each analytical solution, (ii) potential error, and (iii) experimental time. For increased generality, a series of numerical analyses are performed using unified dimensionless parameters and the results are all related to dimensionless reservoir volume (DRV) which includes only the sorptive parameter as an unknown. This means the above factors can be investigated on the basis of the sorption properties of the testing material and/or tracer. The main findings are that steady, quasi-steady and equilibrium-state analyses are applicable when the tracer is not highly sorptive. However, quasi-steady and equilibrium-state analyses become inefficient or impractical compared to steady state analysis when the tracer is non-sorbing and material porosity is significantly low. Systematic and comprehensive reformulation of analytical models enables the comparison of experimental times between different test methods. The applicability and potential error of each test interpretation can also be studied. These can be applied in designing, performing, and interpreting diffusion experiments by deducing DRV from the available information for the target material and tracer, combined with the results of this study.

Approach to interpret images produced by new generations of multidetector CT scanners in post-operative spine.

PubMed

Zeitoun, Rania; Hussein, Manar

2017-11-01

To reach a practical approach to interpret MDCT findings in post-operative spine cases and to change the false belief of CT failure in the setting of instruments secondary to related artefacts. We performed observational retrospective analysis of premier, early and late MDCT scans in 68 post-operative spine patients, with emphasis on instruments related complications and osseous fusion status. We used a grading system for assessment of osseous fusion in 35 patients and we further analysed the findings in failure of fusion, grade (D). We observed a variety of instruments related complications (mostly screws medially penetrating the pedicle) and osseous fusion status in late scans. We graded 11 interbody and 14 posterolateral levels as osseous fusion failure, showing additional instruments related complications, end plates erosive changes, adjacent segments spondylosis and malalignment. Modern MDCT scanners provide high quality images and are strongly recommended in assessment of the instruments and status of osseous fusion. In post-operative imaging of the spine, it is essential to be aware for what you are looking for, in relevance to the date of surgery. Advances in knowledge: Modern MDCT scanners allow assessment of instruments position and integrity and osseous fusion status in post-operative spine. We propose a helpful algorithm to simplify interpreting post-operative spine imaging.

Financial Forecasting and Stochastic Modeling: Predicting the Impact of Business Decisions.

PubMed

Rubin, Geoffrey D; Patel, Bhavik N

2017-05-01

In health care organizations, effective investment of precious resources is critical to assure that the organization delivers high-quality and sustainable patient care within a supportive environment for patients, their families, and the health care providers. This holds true for organizations independent of size, from small practices to large health systems. For radiologists whose role is to oversee the delivery of imaging services and the interpretation, communication, and curation of imaging-informed information, business decisions influence where and how they practice, the tools available for image acquisition and interpretation, and ultimately their professional satisfaction. With so much at stake, physicians must understand and embrace the methods necessary to develop and interpret robust financial analyses so they effectively participate in and better understand decision making. This review discusses the financial drivers upon which health care organizations base investment decisions and the central role that stochastic financial modeling should play in support of strategically aligned capital investments. Given a health care industry that has been slow to embrace advanced financial analytics, a fundamental message of this review is that the skills and analytical tools are readily attainable and well worth the effort to implement in the interest of informed decision making. © RSNA, 2017 Online supplemental material is available for this article.

Challenges of mediated communication, disclosure and patient autonomy in cross-cultural cancer care

PubMed Central

Kai, J; Beavan, J; Faull, C

2011-01-01

Background: Evidence concerning the influence of ethnic diversity on clinical encounters in cancer care is sparse. We explored health providers' experiences in this context. Methods: Focus groups were conducted with a purposeful sample of 106 health professionals of differing disciplines, in 18 UK primary and secondary care settings. Qualitative data were analysed using constant comparison and processes for validation. Results: Communication and the quality of information exchanged with patients about cancer and their treatment was commonly frustrated within interpreter-mediated consultations, particularly those involving a family member. Relatives' approach to ownership of information and decision making could hinder assessment, informed consent and discussion of care with patients. This magnified the complexity of disclosing information sensitively and appropriately at the end of life. Professionals' concern to be patient-centred, and regard for patient choice and autonomy, were tested in these circumstances. Conclusion: Health professionals require better preparation to work effectively not only with trained interpreters, but also with the common reality of patients' families interpreting for patients, to improve quality of cancer care. Greater understanding of cultural and individual variations in concepts of disclosure, patient autonomy and patient-centredness is needed. The extent to which these concepts may be ethnocentric and lack universality deserves wider consideration. PMID:21863029

Family members of older persons with multi-morbidity and their experiences of case managers in Sweden: an interpretive phenomenological approach

PubMed Central

Hjelm, Markus; Holmgren, Ann-Charlotte; Willman, Ania; Bohman, Doris; Holst, Göran

2015-01-01

Background Family members of older persons (75+) with multi-morbidity are likely to benefit from utilising case management services performed by case managers. However, research has not yet explored their experiences of case managers. Objectives The aim of the study was to deepen the understanding of the importance of case managers to family members of older persons (75+) with multi-morbidity. Design The study design was based on an interpretive phenomenological approach. Method Data were collected through individual interviews with 16 family members in Sweden. The interviews were analysed by means of an interpretive phenomenological approach. Results The findings revealed one overarching theme: “Helps to fulfil my unmet needs”, based on three sub-themes: (1) “Helps me feel secure – Experiencing a trusting relationship”, (2) “Confirms and strengthens me – Challenging my sense of being alone” and (3) “Being my personal guide – Increasing my competence”. Conclusion and discussion The findings indicate that case managers were able to fulfil unmet needs of family members. The latter recognised the importance of case managers providing them with professional services tailored to their individual needs. The findings can contribute to the improvement of case management models not only for older persons but also for their family members. PMID:25918497

Chemistry of diagenetic features analyzed by ChemCam at Pahrump Hills, Gale crater, Mars

DOE PAGES

Nachon, M.; Mangold, N.; Forni, O.; ...

2017-09-01

The Curiosity rover's campaign at Pahrump Hills provides the first analyses of lower Mount Sharp strata. We report ChemCam elemental composition of a diverse assemblage of post-depositional features embedded in, or cross-cutting, the host rock. ChemCam results demonstrate their compositional diversity, especially compared to the surrounding host rock: (i) Dendritic aggregates and relief enhanced features, characterized by a magnesium enhancement and sulfur detection, and interpreted as Mg-sulfates; (ii) A localized observation that displays iron enrichment associated with sulfur, interpreted as Fe-sulfate; (iii) Dark raised ridges with varying Mg- and Ca-enriched compositions compared to host rock; (iv) Several dark-toned veins withmore » calcium enhancement associated with fluorine detection, interpreted as fluorite veins. (v) Light-toned veins with enhanced calcium associated with sulfur detection, and interpreted as Ca-sulfates. The diversity of the Pahrump Hills diagenetic assemblage suggests a complex post-depositional history for fine-grained sediments for which the origin has been interpreted as fluvial and lacustrine. Assessment of the spatial and relative temporal distribution of these features shows that the Mg-sulfate features are predominant in the lower part of the section, suggesting local modification of the sediments by early diagenetic fluids. Conversely, light-toned Ca-sulfate veins occur in the whole section and cross-cut all other features. A relatively late stage shift in geochemical conditions could explain this observation. The Pahrump Hills diagenetic features have no equivalent compared to targets analyzed in other locations at Gale crater. Only the light-toned Ca-sulfate veins are present elsewhere, along Curiosity's path, suggesting they formed through a common late-stage process that occurred at over a broad area.« less

Chemistry of diagenetic features analyzed by ChemCam at Pahrump Hills, Gale crater, Mars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nachon, M.; Mangold, N.; Forni, O.

The Curiosity rover's campaign at Pahrump Hills provides the first analyses of lower Mount Sharp strata. We report ChemCam elemental composition of a diverse assemblage of post-depositional features embedded in, or cross-cutting, the host rock. ChemCam results demonstrate their compositional diversity, especially compared to the surrounding host rock: (i) Dendritic aggregates and relief enhanced features, characterized by a magnesium enhancement and sulfur detection, and interpreted as Mg-sulfates; (ii) A localized observation that displays iron enrichment associated with sulfur, interpreted as Fe-sulfate; (iii) Dark raised ridges with varying Mg- and Ca-enriched compositions compared to host rock; (iv) Several dark-toned veins withmore » calcium enhancement associated with fluorine detection, interpreted as fluorite veins. (v) Light-toned veins with enhanced calcium associated with sulfur detection, and interpreted as Ca-sulfates. The diversity of the Pahrump Hills diagenetic assemblage suggests a complex post-depositional history for fine-grained sediments for which the origin has been interpreted as fluvial and lacustrine. Assessment of the spatial and relative temporal distribution of these features shows that the Mg-sulfate features are predominant in the lower part of the section, suggesting local modification of the sediments by early diagenetic fluids. Conversely, light-toned Ca-sulfate veins occur in the whole section and cross-cut all other features. A relatively late stage shift in geochemical conditions could explain this observation. The Pahrump Hills diagenetic features have no equivalent compared to targets analyzed in other locations at Gale crater. Only the light-toned Ca-sulfate veins are present elsewhere, along Curiosity's path, suggesting they formed through a common late-stage process that occurred at over a broad area.« less

A comparison of two- and three-dimensional stochastic models of regional solute movement

USGS Publications Warehouse

Shapiro, A.M.; Cvetkovic, V.D.

1990-01-01

Recent models of solute movement in porous media that are based on a stochastic description of the porous medium properties have been dedicated primarily to a three-dimensional interpretation of solute movement. In many practical problems, however, it is more convenient and consistent with measuring techniques to consider flow and solute transport as an areal, two-dimensional phenomenon. The physics of solute movement, however, is dependent on the three-dimensional heterogeneity in the formation. A comparison of two- and three-dimensional stochastic interpretations of solute movement in a porous medium having a statistically isotropic hydraulic conductivity field is investigated. To provide an equitable comparison between the two- and three-dimensional analyses, the stochastic properties of the transmissivity are defined in terms of the stochastic properties of the hydraulic conductivity. The variance of the transmissivity is shown to be significantly reduced in comparison to that of the hydraulic conductivity, and the transmissivity is spatially correlated over larger distances. These factors influence the two-dimensional interpretations of solute movement by underestimating the longitudinal and transverse growth of the solute plume in comparison to its description as a three-dimensional phenomenon. Although this analysis is based on small perturbation approximations and the special case of a statistically isotropic hydraulic conductivity field, it casts doubt on the use of a stochastic interpretation of the transmissivity in describing regional scale movement. However, by assuming the transmissivity to be the vertical integration of the hydraulic conductivity field at a given position, the stochastic properties of the hydraulic conductivity can be estimated from the stochastic properties of the transmissivity and applied to obtain a more accurate interpretation of solute movement. ?? 1990 Kluwer Academic Publishers.

Chemistry of diagenetic features analyzed by ChemCam at Pahrump Hills, Gale crater, Mars

USGS Publications Warehouse

Nachon, Marion; Mangold, Nicolas; Forni, Olivier; Kah, Linda C.; Cousin, Agnes; Wiens, Roger C.; Anderson, Ryan; Blaney, Diana L.; Blank, Jen G.; Calef, Fred J.; Clegg, Samuel M.; Fabre, Cecile; Fisk, Martin R.; Gasnault, Olivier; Grotzinger, John P.; Kronyak, Rachel; Lanza, Nina L.; Lasue, Jeremie; Le Deit, Laetitia; Le Mouelic, Stephane; Maurice, Sylvestre; Meslin, Pierre-Yves; Oehler, D. Z.; Payre, Valerie; Rapin, William; Schroder, Susanne; Stack, Katherine M.; Sumner, Dawn

2017-01-01

The Curiosity rover's campaign at Pahrump Hills provides the first analyses of lower Mount Sharp strata. Here we report ChemCam elemental composition of a diverse assemblage of post-depositional features embedded in, or cross-cutting, the host rock. ChemCam results demonstrate their compositional diversity, especially compared to the surrounding host rock: (i) Dendritic aggregates and relief enhanced features, characterized by a magnesium enhancement and sulfur detection, and interpreted as Mg-sulfates; (ii) A localized observation that displays iron enrichment associated with sulfur, interpreted as Fe-sulfate; (iii) Dark raised ridges with varying Mg- and Ca-enriched compositions compared to host rock; (iv) Several dark-toned veins with calcium enhancement associated with fluorine detection, interpreted as fluorite veins. (v) Light-toned veins with enhanced calcium associated with sulfur detection, and interpreted as Ca-sulfates. The diversity of the Pahrump Hills diagenetic assemblage suggests a complex post-depositional history for fine-grained sediments for which the origin has been interpreted as fluvial and lacustrine. Assessment of the spatial and relative temporal distribution of these features shows that the Mg-sulfate features are predominant in the lower part of the section, suggesting local modification of the sediments by early diagenetic fluids. In contrast, light-toned Ca-sulfate veins occur in the whole section and cross-cut all other features. A relatively late stage shift in geochemical conditions could explain this observation. The Pahrump Hills diagenetic features have no equivalent compared to targets analyzed in other locations at Gale crater. Only the light-toned Ca-sulfate veins are present elsewhere, along Curiosity's path, suggesting they formed through a common late-stage process that occurred at over a broad area.

Geological, geomorphological, facies and allostratigraphic maps of the Eberswalde fan delta

NASA Astrophysics Data System (ADS)

Pondrelli, M.; Rossi, A. P.; Platz, T.; Ivanov, A.; Marinangeli, L.; Baliva, A.

2011-09-01

Geological, facies, geomorphological and allostratigraphic map of the Eberswalde fan delta area are presented. The Eberswalde fan delta is proposed as a sort of prototype area to map sedimentary deposits, because of its excellent data coverage and its variability in depositional as well as erosional morphologies and sedimentary facies. We present a report to distinguish different cartographic products implying an increasing level of interpretation. The geological map - in association with the facies map - represents the most objective mapping product. Formations are distinguished on the basis of objectively observable parameters: texture, color, sedimentary structures and geographic distribution. Stratigraphic relations are evaluated using Steno's principles. Formations can be interpreted in terms of depositional environment, but an eventual change of the genetic interpretation would not lead to a change in the geological map. The geomorphological map is based on the data represented in the geological map plus the association of the morphological elements, in order to infer the depositional sub-environments. As a consequence, it is an interpretative map focused on the genetic reconstruction. The allostratigraphic map is based on the morphofacies analysis - expressed by the geomorphological map - and by the recognition of surfaces which reflect allogenic controls, such as water level fluctuations: unconformities, erosional truncations and flooding surfaces. As a consequence, this is an even more interpretative map than the geomorphological one, since it focuses on the control on the sedimentary systems. Geological maps represent the most suitable cartographic product for a systematic mapping, which can serve as a prerequisite for scientific or landing site analyses. Geomorphological and allostratographic maps are suitable tools to broaden scientific analysis or to provide scientific background to landing site selection.

Ultraweak photon emission and proteomics analyses in soybean under abiotic stress.

PubMed

Komatsu, Setsuko; Kamal, Abu Hena Mostafa; Makino, Takahiro; Hossain, Zahed

2014-07-01

Biophotons are ultraweak photon emissions that are closely related to various biological activities and processes. In mammals, biophoton emissions originate from oxidative bursts in immunocytes during immunological responses. Biophotons emitted from plant organs provide novel information about the physiological state of plant under in vivo condition. In this review, the principles and recent advances in the measurement of biophoton emissions in plants are described. Furthermore, examples of biophoton emission and proteomics in soybean under abiotic stress are reviewed and discussed. Finally, this review suggests that the application of proteomics should provide a better interpretation of plant response to biophoton emission and allow the identification of genes that will allow the screening of crops able to produce maximal yields, even in stressful environments. Copyright © 2014 Elsevier B.V. All rights reserved.

Decision making within a community provider organization.

PubMed

Berggren, Ingela; Carlstrom, Eric

2010-12-01

To explore community nurses' experiences of decision making within the community provider organization. Recent changes in health care with an increasing number of patients being cared for outside of institutions can put considerable pressure on the nurse with respect to decision making. In-depth interviews were performed with 6 registered nurses in two communities. The interviews were analysed by means of phenomenological hermeneutics. The community nurses' experiences of decision making were interpreted as spiders or octopuses, consultants and troubleshooters. The subthemes were; networking and structuring, responsibility, availability and knowledge, assessment power, information selection, avoiding rules and bypassing managers. In accordance with hermeneutical phenomenology, the findings were discussed and explained with reference to Ofstad's philosophy of freedom to make decisions. In their decision making, community nurses are committed to finding administrative solutions that satisfy patient needs.

Morbidity study of extruder personnel with potential exposure to brominated dioxins and furans. II. Results of clinical laboratory studies.

PubMed Central

Ott, M G; Zober, A

1996-01-01

OBJECTIVE: To test whether dioxins affect liver and thyroid function, lipid metabolism and glucose or immunological variables, in workers exposed to brominated dioxins and furans. METHODS: 34 male production employees (29 were extruder operators) and eight technical support personnel were studied, all of whom were potentially exposed to polybrominated dibenzo-p-dioxins (PBDDs) and furans (PBDFs) during production of resins containing polybrominated diphenyl ethers (PBDEs). Controls were from a similar resin producing plant that did not use PBDEs. Blood samples were analysed for tetra, penta, and hexabrominated congeners, but 2,3,7,8-TBDD was the only exposure measure used in the regression analyses. Seven liver function indicators, five measures of blood lipids and glucose, four haematology and blood coagulation measures, and three measures of thyroid function were examined. RESULTS: None of the variables was statistically related to concentration of 2,3,7,8-TBDD in the regression analyses. Cigarette smoking was related to several outcomes at the 0.05 level: aspartate aminotransferase, alanine aminotransferase, glutamate dehydrogenase (GLDH), erythrocyte sedimentation rate, and white blood cell count. Body mass index was also related to alanine aminotransferase, gamma-glutamyltranspeptidase, cholinesterase, GLDH, cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, and glucose concentrations. No definitive associations between liver, blood lipid, thyroid, or immunological variables and exposure to brominated dioxins or blood lipid concentration of 2,3,7,8-TBDD were found. CONCLUSIONS: The study population was small and hence the findings must be interpreted with caution. Nevertheless, these results provide a base for interpreting the results of clinical studies in similarly exposed populations. PMID:8994404

Research applications for an Object and Action Naming Battery to assess naming skills in adult Spanish-English bilingual speakers.

PubMed

Edmonds, Lisa A; Donovan, Neila J

2014-06-01

Virtually no valid materials are available to evaluate confrontation naming in Spanish-English bilingual adults in the U.S. In a recent study, a large group of young Spanish-English bilingual adults were evaluated on An Object and Action Naming Battery (Edmonds & Donovan in Journal of Speech, Language, and Hearing Research 55:359-381, 2012). Rasch analyses of the responses resulted in evidence for the content and construct validity of the retained items. However, the scope of that study did not allow for extensive examination of individual item characteristics, group analyses of participants, or the provision of testing and scoring materials or raw data, thereby limiting the ability of researchers to administer the test to Spanish-English bilinguals and to score the items with confidence. In this study, we present the in-depth information described above on the basis of further analyses, including (1) online searchable spreadsheets with extensive empirical (e.g., accuracy and name agreeability) and psycholinguistic item statistics; (2) answer sheets and instructions for scoring and interpreting the responses to the Rasch items; (3) tables of alternative correct responses for English and Spanish; (4) ability strata determined for all naming conditions (English and Spanish nouns and verbs); and (5) comparisons of accuracy across proficiency groups (i.e., Spanish dominant, English dominant, and balanced). These data indicate that the Rasch items from An Object and Action Naming Battery are valid and sensitive for the evaluation of naming in young Spanish-English bilingual adults. Additional information based on participant responses for all of the items on the battery can provide researchers with valuable information to aid in stimulus development and response interpretation for experimental studies in this population.

U.S. Geological Survey: A synopsis of Three-dimensional Modeling

USGS Publications Warehouse

Jacobsen, Linda J.; Glynn, Pierre D.; Phelps, Geoff A.; Orndorff, Randall C.; Bawden, Gerald W.; Grauch, V.J.S.

2011-01-01

The U.S. Geological Survey (USGS) is a multidisciplinary agency that provides assessments of natural resources (geological, hydrological, biological), the disturbances that affect those resources, and the disturbances that affect the built environment, natural landscapes, and human society. Until now, USGS map products have been generated and distributed primarily as 2-D maps, occasionally providing cross sections or overlays, but rarely allowing the ability to characterize and understand 3-D systems, how they change over time (4-D), and how they interact. And yet, technological advances in monitoring natural resources and the environment, the ever-increasing diversity of information needed for holistic assessments, and the intrinsic 3-D/4-D nature of the information obtained increases our need to generate, verify, analyze, interpret, confirm, store, and distribute its scientific information and products using 3-D/4-D visualization, analysis, modeling tools, and information frameworks. Today, USGS scientists use 3-D/4-D tools to (1) visualize and interpret geological information, (2) verify the data, and (3) verify their interpretations and models. 3-D/4-D visualization can be a powerful quality control tool in the analysis of large, multidimensional data sets. USGS scientists use 3-D/4-D technology for 3-D surface (i.e., 2.5-D) visualization as well as for 3-D volumetric analyses. Examples of geological mapping in 3-D include characterization of the subsurface for resource assessments, such as aquifer characterization in the central United States, and for input into process models, such as seismic hazards in the western United States.

Cyclic and Fatigue Behaviour of Rock Materials: Review, Interpretation and Research Perspectives

NASA Astrophysics Data System (ADS)

Cerfontaine, B.; Collin, F.

2018-02-01

The purpose of this paper is to provide a comprehensive state of the art of fatigue and cyclic loading of natural rock materials. Papers published in the literature are classified and listed in order to ease bibliographical review, to gather data (sometimes contradictory) on classical experimental results and to analyse the main interpretation concepts. Their advantages and limitations are discussed, and perspectives for further work are highlighted. The first section summarises and defines the different experimental set-ups (type of loading, type of experiment) already applied to cyclic/fatigue investigation of rock materials. The papers are then listed based on these different definitions. Typical results are highlighted in next section. Fatigue/cyclic loading mainly results in accumulation of plastic deformation and/or damage cycle after cycle. A sample cyclically loaded at constant amplitude finally leads to failure even if the peak load is lower than its monotonic strength. This subcritical crack is due to a diffuse microfracturing and decohesion of the rock structure. The third section reviews and comments the concepts used to interpret the results. The fatigue limit and S- N curves are the most common concepts used to describe fatigue experiments. Results published from all papers are gathered into a single figure to highlight the tendency. Predicting the monotonic peak strength of a sample is found to be critical in order to compute accurate S- N curves. Finally, open questions are listed to provide a state of the art of grey areas in the understanding of fatigue mechanisms and challenges for the future.

Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review.

PubMed

Camomilla, Valentina; Cereatti, Andrea; Cutti, Andrea Giovanni; Fantozzi, Silvia; Stagni, Rita; Vannozzi, Giuseppe

2017-08-18

Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. ground reaction forces, skin marker trajectories, etc.) through biomechanical modelling. In particular, the estimation of joint moments during motion is grounded on several modelling assumptions: (1) body segmental and joint kinematics is derived from the trajectories of markers and by modelling the human body as a kinematic chain; (2) joint resultant (net) loads are, usually, derived from force plate measurements through a model of segmental dynamics. Therefore, both measurement errors and modelling assumptions can affect the results, to an extent that also depends on the characteristics of the motor task analysed (i.e. gait speed). Errors affecting the trajectories of joint centres, the orientation of joint functional axes, the joint angular velocities, the accuracy of inertial parameters and force measurements (concurring to the definition of the dynamic model), can weigh differently in the estimation of clinically interpretable joint moments. Numerous studies addressed all these methodological aspects separately, but a critical analysis of how these aspects may affect the clinical interpretation of joint dynamics is still missing. This article aims at filling this gap through a systematic review of the literature, conducted on Web of Science, Scopus and PubMed. The final objective is hence to provide clear take-home messages to guide laboratories in the estimation of joint moments for the clinical practice.

Using and interpreting mental health measures in the National Social Life, Health, and Aging Project.

PubMed

Payne, Carolyn; Hedberg, E C; Kozloski, Michael; Dale, William; McClintock, Martha K

2014-11-01

National Social Life, Health, and Aging Project (NSHAP) included five unique mental health measures in Waves 1 and 2 that researchers can use to measure the overall emotional health of participants: depressive symptoms, happiness-unhappiness, anxiety symptoms, perceived stress, and felt loneliness. For each, we detail the rationale for its development and explain how to score, analyze, and interpret results. NSHAP developed its measures by modifying traditional short-form scales to improve response efficiency and reduce respondent burden. Scoring protocols and interpretations were developed for each measure. U.S. population estimates for older adults born between 1920 and 1947 were generated using age-eligible samples from Waves 1 and 2. NSHAP's protocols yielded U.S. prevalence rates similar to other nationally representative studies of older adults and comparable between waves. Higher estimates of anxiety symptoms and perceived stress in Wave 2 compared with Wave 1 were explained by age, administration mode, and time period. Analytic strategies for longitudinal analyses are provided. In Wave 2, mental health generally was worse at older ages, with women having more symptoms at younger ages than men. Women had fewer anxiety symptoms at the oldest ages. NSHAP's mental health measures were successfully integrated into the project's survey and showed acceptable external reliability as well as moderately stable individual characteristics across the 5 years between Waves 1 and 2. Depressive symptoms and unhappiness may form a mental health cluster in the elderly, distinct from anxiety symptoms, perceived stress, and felt loneliness. Gender differences in age-specific patterns of mental health were evident using the exact age of participants rather than the traditional decade groupings. Administration mode and time period (between 2005-2006 and 2010-2011) were determined to be potential confounds that need to be accommodated in longitudinal analyses of aging, whereas sample composition was not an issue for interpreting mental health measures. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Methodologies for Reservoir Characterization Using Fluid Inclusion Gas Chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dilley, Lorie M.

2015-04-13

The purpose of this project was to: 1) evaluate the relationship between geothermal fluid processes and the compositions of the fluid inclusion gases trapped in the reservoir rocks; and 2) develop methodologies for interpreting fluid inclusion gas data in terms of the chemical, thermal and hydrological properties of geothermal reservoirs. Phase 1 of this project was designed to conduct the following: 1) model the effects of boiling, condensation, conductive cooling and mixing on selected gaseous species; using fluid compositions obtained from geothermal wells, 2) evaluate, using quantitative analyses provided by New Mexico Tech (NMT), how these processes are recorded bymore » fluid inclusions trapped in individual crystals; and 3) determine if the results obtained on individual crystals can be applied to the bulk fluid inclusion analyses determined by Fluid Inclusion Technology (FIT). Our initial studies however, suggested that numerical modeling of the data would be premature. We observed that the gas compositions, determined on bulk and individual samples were not the same as those discharged by the geothermal wells. Gases discharged from geothermal wells are CO 2-rich and contain low concentrations of light gases (i.e. H 2, He, N, Ar, CH4). In contrast many of our samples displayed enrichments in these light gases. Efforts were initiated to evaluate the reasons for the observed gas distributions. As a first step, we examined the potential importance of different reservoir processes using a variety of commonly employed gas ratios (e.g. Giggenbach plots). The second technical target was the development of interpretational methodologies. We have develop methodologies for the interpretation of fluid inclusion gas data, based on the results of Phase 1, geologic interpretation of fluid inclusion data, and integration of the data. These methodologies can be used in conjunction with the relevant geological and hydrological information on the system to create fluid models for the system. The hope is that the methodologies developed will allow bulk fluid inclusion gas analysis to be a useful tool for estimating relative temperatures, identifying the sources and origins of the geothermal fluids, and developing conceptual models that can be used to help target areas of enhanced permeability.« less

Legal and Ethical Imperatives for Using Certified Sign Language Interpreters in Health Care Settings: How to "Do No Harm" When "It's (All) Greek" (Sign Language) to You.

PubMed

Nonaka, Angela M

2016-09-01

Communication obstacles in health care settings adversely impact patient-practitioner interactions by impeding service efficiency, reducing mutual trust and satisfaction, or even endangering health outcomes. When interlocutors are separated by language, interpreters are required. The efficacy of interpreting, however, is constrained not just by interpreters' competence but also by health care providers' facility working with interpreters. Deaf individuals whose preferred form of communication is a signed language often encounter communicative barriers in health care settings. In those environments, signing Deaf people are entitled to equal communicative access via sign language interpreting services according to the Americans with Disabilities Act and Executive Order 13166, the Limited English Proficiency Initiative. Yet, litigation in states across the United States suggests that individual and institutional providers remain uncertain about their legal obligations to provide equal communicative access. This article discusses the legal and ethical imperatives for using professionally certified (vs. ad hoc) sign language interpreters in health care settings. First outlining the legal terrain governing provision of sign language interpreting services, the article then describes different types of "sign language" (e.g., American Sign Language vs. manually coded English) and different forms of "sign language interpreting" (e.g., interpretation vs. transliteration vs. translation; simultaneous vs. consecutive interpreting; individual vs. team interpreting). This is followed by reviews of the formal credentialing process and of specialized forms of sign language interpreting-that is, certified deaf interpreting, trilingual interpreting, and court interpreting. After discussing practical steps for contracting professional sign language interpreters and addressing ethical issues of confidentiality, this article concludes by offering suggestions for working more effectively with Deaf clients via professional sign language interpreters.

Probabilistic seismic hazard analyses for ground motions and fault displacement at Yucca Mountain, Nevada

USGS Publications Warehouse

Stepp, J.C.; Wong, I.; Whitney, J.; Quittmeyer, R.; Abrahamson, N.; Toro, G.; Young, S.R.; Coppersmith, K.; Savy, J.; Sullivan, T.

2001-01-01

Probabilistic seismic hazard analyses were conducted to estimate both ground motion and fault displacement hazards at the potential geologic repository for spent nuclear fuel and high-level radioactive waste at Yucca Mountain, Nevada. The study is believed to be the largest and most comprehensive analyses ever conducted for ground-shaking hazard and is a first-of-a-kind assessment of probabilistic fault displacement hazard. The major emphasis of the study was on the quantification of epistemic uncertainty. Six teams of three experts performed seismic source and fault displacement evaluations, and seven individual experts provided ground motion evaluations. State-of-the-practice expert elicitation processes involving structured workshops, consensus identification of parameters and issues to be evaluated, common sharing of data and information, and open exchanges about the basis for preliminary interpretations were implemented. Ground-shaking hazard was computed for a hypothetical rock outcrop at -300 m, the depth of the potential waste emplacement drifts, at the designated design annual exceedance probabilities of 10-3 and 10-4. The fault displacement hazard was calculated at the design annual exceedance probabilities of 10-4 and 10-5.

Consistency of QSAR models: Correct split of training and test sets, ranking of models and performance parameters.

PubMed

Rácz, A; Bajusz, D; Héberger, K

2015-01-01

Recent implementations of QSAR modelling software provide the user with numerous models and a wealth of information. In this work, we provide some guidance on how one should interpret the results of QSAR modelling, compare and assess the resulting models, and select the best and most consistent ones. Two QSAR datasets are applied as case studies for the comparison of model performance parameters and model selection methods. We demonstrate the capabilities of sum of ranking differences (SRD) in model selection and ranking, and identify the best performance indicators and models. While the exchange of the original training and (external) test sets does not affect the ranking of performance parameters, it provides improved models in certain cases (despite the lower number of molecules in the training set). Performance parameters for external validation are substantially separated from the other merits in SRD analyses, highlighting their value in data fusion.

The cost and utilisation patterns of a pilot sign language interpreter service for primary health care services in South Africa

PubMed Central

Heap, Marion; Sinanovic, Edina

2017-01-01

Background The World Health Organisation estimates disabling hearing loss to be around 5.3%, while a study of hearing impairment and auditory pathology in Limpopo, South Africa found a prevalence of nearly 9%. Although Sign Language Interpreters (SLIs) improve the communication challenges in health care, they are unaffordable for many signing Deaf people and people with disabling hearing loss. On the other hand, there are no legal provisions in place to ensure the provision of SLIs in the health sector in most countries including South Africa. To advocate for funding of such initiatives, reliable cost estimates are essential and such data is scarce. To bridge this gap, this study estimated the costs of providing such a service within a South African District health service based on estimates obtained from a pilot-project that initiated the first South African Sign Language Interpreter (SASLI) service in health-care. Methods The ingredients method was used to calculate the unit cost per SASLI-assisted visit from a provider perspective. The unit costs per SASLI-assisted visit were then used in estimating the costs of scaling up this service to the District Health Services. The average annual SASLI utilisation rate per person was calculated on Stata v.12 using the projects’ registry from 2008–2013. Sensitivity analyses were carried out to determine the effect of changing the discount rate and personnel costs. Results Average Sign Language Interpreter services’ utilisation rates increased from 1.66 to 3.58 per person per year, with a median of 2 visits, from 2008–2013. The cost per visit was US$189.38 in 2013 whilst the estimated costs of scaling up this service ranged from US$14.2million to US$76.5million in the Cape Metropole District. These cost estimates represented 2.3%-12.2% of the budget for the Western Cape District Health Services for 2013. Conclusions In the presence of Sign Language Interpreters, Deaf Sign language users utilise health care service to a similar extent as the hearing population. However, this service requires significant capital investment by government to enable access to healthcare for the Deaf. PMID:29272272

The cost and utilisation patterns of a pilot sign language interpreter service for primary health care services in South Africa.

PubMed

Zulu, Tryphine; Heap, Marion; Sinanovic, Edina

2017-01-01

The World Health Organisation estimates disabling hearing loss to be around 5.3%, while a study of hearing impairment and auditory pathology in Limpopo, South Africa found a prevalence of nearly 9%. Although Sign Language Interpreters (SLIs) improve the communication challenges in health care, they are unaffordable for many signing Deaf people and people with disabling hearing loss. On the other hand, there are no legal provisions in place to ensure the provision of SLIs in the health sector in most countries including South Africa. To advocate for funding of such initiatives, reliable cost estimates are essential and such data is scarce. To bridge this gap, this study estimated the costs of providing such a service within a South African District health service based on estimates obtained from a pilot-project that initiated the first South African Sign Language Interpreter (SASLI) service in health-care. The ingredients method was used to calculate the unit cost per SASLI-assisted visit from a provider perspective. The unit costs per SASLI-assisted visit were then used in estimating the costs of scaling up this service to the District Health Services. The average annual SASLI utilisation rate per person was calculated on Stata v.12 using the projects' registry from 2008-2013. Sensitivity analyses were carried out to determine the effect of changing the discount rate and personnel costs. Average Sign Language Interpreter services' utilisation rates increased from 1.66 to 3.58 per person per year, with a median of 2 visits, from 2008-2013. The cost per visit was US$189.38 in 2013 whilst the estimated costs of scaling up this service ranged from US$14.2million to US$76.5million in the Cape Metropole District. These cost estimates represented 2.3%-12.2% of the budget for the Western Cape District Health Services for 2013. In the presence of Sign Language Interpreters, Deaf Sign language users utilise health care service to a similar extent as the hearing population. However, this service requires significant capital investment by government to enable access to healthcare for the Deaf.

Doubly blind: a systematic review of gender in randomised controlled trials.

PubMed

Phillips, Susan P; Hamberg, Katarina

2016-01-01

Although observational data show social characteristics such as gender or socio-economic status to be strong predictors of health, their impact is seldom investigated in randomised controlled studies (RCTs). Using a random sample of recent RCTs from high-impact journals, we examined how the most often recorded social characteristic, sex/gender, is considered in design, analysis, and interpretation. Of 712 RCTs published from September 2008 to 31 December 2013 in the Annals of Internal Medicine, British Medical Journal, Lancet, Canadian Medical Association Journal, or New England Journal of Medicine, we randomly selected 57 to analyse funding, methods, number of centres, documentation of social circumstances, inclusion/exclusion criteria, proportions of women/men, and reporting about sex/gender in analyses and discussion. Participants' sex was recorded in most studies (52/57). Thirty-nine percent included men and women approximately equally. Overrepresentation of men in 43% of studies without explicit exclusions for women suggested interference in selection processes. The minority of studies that did analyse sex/gender differences (22%) did not discuss or reflect upon these, or dismissed significant findings. Two studies reinforced traditional beliefs about women's roles, finding no impact of breastfeeding on infant health but nevertheless reporting possible benefits. Questionable methods such as changing protocols mid-study, having undefined exclusion criteria, allowing local researchers to remove participants from studies, and suggesting possible benefit where none was found were evident, particularly in industry-funded research. Social characteristics like sex/gender remain hidden from analyses and interpretation in RCTs, with loss of information and embedding of error all along the path from design to interpretation, and therefore, to uptake in clinical practice. Our results suggest that to broaden external validity, in particular, more refined trial designs and analyses that account for sex/gender and other social characteristics are needed.

Interpretation biases in paranoia.

PubMed

Savulich, George; Freeman, Daniel; Shergill, Sukhi; Yiend, Jenny

2015-01-01

Information in the environment is frequently ambiguous in meaning. Emotional ambiguity, such as the stare of a stranger, or the scream of a child, encompasses possible good or bad emotional consequences. Those with elevated vulnerability to affective disorders tend to interpret such material more negatively than those without, a phenomenon known as "negative interpretation bias." In this study we examined the relationship between vulnerability to psychosis, measured by trait paranoia, and interpretation bias. One set of material permitted broadly positive/negative (valenced) interpretations, while another allowed more or less paranoid interpretations, allowing us to also investigate the content specificity of interpretation biases associated with paranoia. Regression analyses (n=70) revealed that trait paranoia, trait anxiety, and cognitive inflexibility predicted paranoid interpretation bias, whereas trait anxiety and cognitive inflexibility predicted negative interpretation bias. In a group comparison those with high levels of trait paranoia were negatively biased in their interpretations of ambiguous information relative to those with low trait paranoia, and this effect was most pronounced for material directly related to paranoid concerns. Together these data suggest that a negative interpretation bias occurs in those with elevated vulnerability to paranoia, and that this bias may be strongest for material matching paranoid beliefs. We conclude that content-specific biases may be important in the cause and maintenance of paranoid symptoms. Copyright © 2014. Published by Elsevier Ltd.

Kidney function changes with aging in adults: comparison between cross-sectional and longitudinal data analyses in renal function assessment.

PubMed

Chung, Sang M; Lee, David J; Hand, Austin; Young, Philip; Vaidyanathan, Jayabharathi; Sahajwalla, Chandrahas

2015-12-01

The study evaluated whether the renal function decline rate per year with age in adults varies based on two primary statistical analyses: cross-section (CS), using one observation per subject, and longitudinal (LT), using multiple observations per subject over time. A total of 16628 records (3946 subjects; age range 30-92 years) of creatinine clearance and relevant demographic data were used. On average, four samples per subject were collected for up to 2364 days (mean: 793 days). A simple linear regression and random coefficient models were selected for CS and LT analyses, respectively. The renal function decline rates per year were 1.33 and 0.95 ml/min/year for CS and LT analyses, respectively, and were slower when the repeated individual measurements were considered. The study confirms that rates are different based on statistical analyses, and that a statistically robust longitudinal model with a proper sampling design provides reliable individual as well as population estimates of the renal function decline rates per year with age in adults. In conclusion, our findings indicated that one should be cautious in interpreting the renal function decline rate with aging information because its estimation was highly dependent on the statistical analyses. From our analyses, a population longitudinal analysis (e.g. random coefficient model) is recommended if individualization is critical, such as a dose adjustment based on renal function during a chronic therapy. Copyright © 2015 John Wiley & Sons, Ltd.

When Is the Story in the Subgroups? Strategies for Interpreting and Reporting Intervention Effects on Subgroups. MDRC Working Papers on Research Methodology

ERIC Educational Resources Information Center

Bloom, Howard S.; Michalopoulos, Charles

2010-01-01

This paper examines strategies for interpreting and reporting estimates of intervention effects for subgroups of a study sample. Specifically, the paper considers: why and how subgroup findings are important for applied research, the importance of pre-specifying sub- groups before analyses are conducted, the importance of using existing theory and…

Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared With Other Therapies in the Treatment of Knee Osteoarthritis? A Systematic Review of Overlapping Meta-analyses.

PubMed

Campbell, Kirk A; Saltzman, Bryan M; Mascarenhas, Randy; Khair, M Michael; Verma, Nikhil N; Bach, Bernard R; Cole, Brian J

2015-11-01

The aims of this study were (1) to perform a systematic review of meta-analyses evaluating platelet-rich plasma (PRP) injection in the treatment of knee joint cartilage degenerative pathology, (2) to provide a framework for analysis and interpretation of the best available evidence to provide recommendations for use (or lack thereof) of PRP in the setting of knee osteoarthritis (OA), and (3) to identify literature gaps where continued investigation would be suggested. Literature searches were performed for meta-analyses examining use of PRP versus corticosteroids, hyaluronic acid, oral nonsteroidal anti-inflammatory drugs, or placebo. Clinical data were extracted, and meta-analysis quality was assessed. The Jadad algorithm was applied to determine meta-analyses that provided the highest level of evidence. Three meta-analyses met the eligibility criteria and ranged in quality from Level II to Level IV evidence. All studies compared outcomes of treatment with intra-articular platelet-rich plasma (IA-PRP) versus control (intra-articular hyaluronic acid or intra-articular placebo). Use of PRP led to significant improvements in patient outcomes at 6 months after injection, and these improvements were seen starting at 2 months and were maintained for up to 12 months. It is unclear if the use of multiple PRP injections, the double-spinning technique, or activating agents leads to better outcomes. Patients with less radiographic evidence of arthritis benefit more from PRP treatment. The use of multiple PRP injections may increase the risk of self-limited local adverse reactions. After application of the Jadad algorithm, 3 concordant high-quality meta-analyses were selected and all showed that IA-PRP provided clinically relevant improvements in pain and function compared with the control treatment. IA-PRP is a viable treatment for knee OA and has the potential to lead to symptomatic relief for up to 12 months. There appears to be an increased risk of local adverse reactions after multiple PRP injections. IA-PRP offers better symptomatic relief to patients with early knee degenerative changes, and its use should be considered in patients with knee OA. Level IV, systematic review of Level II through IV studies. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Supercritical fluid extraction of the non-polar organic compounds in meteorites

NASA Astrophysics Data System (ADS)

Sephton, M. A.; Pillinger, C. T.; Gilmour, I.

2001-01-01

The carbonaceous chondrite meteorites contain a variety of extraterrestrial organic molecules. These organic components provide a valuable insight into the formation and evolution of the solar system. Attempts at obtaining and interpreting this information source are hampered by the small sample sizes available for study and the interferences from terrestrial contamination. Supercritical fluid extraction represents an efficient and contamination-free means of isolating extraterrestrial molecules. Gas chromatography-mass spectrometry analyses of extracts from Orgueil and Cold Bokkeveld reveal a complex mixture of free non-polar organic molecules which include normal alkanes, isoprenoid alkanes, tetrahydronaphthalenes and aromatic hydrocarbons. These organic assemblages imply contributions from both terrestrial and extraterrestrial sources.

"We are all there silently coping." The hidden experiences of parents of adults with Asperger syndrome.

PubMed

Griffith, Gemma M; Totsika, Vasiliki; Nash, Susie; Jones, Robert S P; Hastings, Richard P

2012-09-01

The experiences of older parents of adults with Asperger syndrome have not been explored in the research literature. Four families who had middle-aged offspring with Asperger syndrome were interviewed (3 mothers and 1 couple), and the interviews were analysed using interpretative phenomenological analysis (IPA). Six themes emerged from the analysis: (a) providers of "hidden" support, (b) role of advocate, (c) social isolation, (d) intrafamilial relationships, (e) support for parents, and (f) future concerns. The findings of this study offer insight into the experience of parents of adult sons with Asperger syndrome. Implications for future support interventions and research are suggested.

MWASTools: an R/bioconductor package for metabolome-wide association studies.

PubMed

Rodriguez-Martinez, Andrea; Posma, Joram M; Ayala, Rafael; Neves, Ana L; Anwar, Maryam; Petretto, Enrico; Emanueli, Costanza; Gauguier, Dominique; Nicholson, Jeremy K; Dumas, Marc-Emmanuel

2018-03-01

MWASTools is an R package designed to provide an integrated pipeline to analyse metabonomic data in large-scale epidemiological studies. Key functionalities of our package include: quality control analysis; metabolome-wide association analysis using various models (partial correlations, generalized linear models); visualization of statistical outcomes; metabolite assignment using statistical total correlation spectroscopy (STOCSY); and biological interpretation of metabolome-wide association studies results. The MWASTools R package is implemented in R (version  > =3.4) and is available from Bioconductor: https://bioconductor.org/packages/MWASTools/. m.dumas@imperial.ac.uk. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

"Association or causation?" The debate on the scientific status of risk factor epidemiology, 1947-c. 1965.

PubMed

Berlivet, Luc

2005-01-01

In the second half of the twentieth century, epidemiology came to shape public health discourses and practices to an unprecedented extent. The chapter explores the transformation of the discipline after World War Two and analyses the crucial debate on the notion of "causation" that sprung from the growing interest in non-transmissible, chronic diseases. A landmark in this history was the controversy over the interpretation of the statistical relationship between smoking and lung cancer prompted by American and British publications in 1950. This sometimes heated debate also provided Austin Bradford Hill with the opportunity to set out his "pragmatics" of risk factor epidemiology.

NASA's Aviation Safety and Modeling Project

NASA Technical Reports Server (NTRS)

Chidester, Thomas R.; Statler, Irving C.

2006-01-01

The Aviation Safety Monitoring and Modeling (ASMM) Project of NASA's Aviation Safety program is cultivating sources of data and developing automated computer hardware and software to facilitate efficient, comprehensive, and accurate analyses of the data collected from large, heterogeneous databases throughout the national aviation system. The ASMM addresses the need to provide means for increasing safety by enabling the identification and correcting of predisposing conditions that could lead to accidents or to incidents that pose aviation risks. A major component of the ASMM Project is the Aviation Performance Measuring System (APMS), which is developing the next generation of software tools for analyzing and interpreting flight data.

Applying Beliefs and Resources Frameworks to the Psychometric Analyses of an Epistemology Survey

ERIC Educational Resources Information Center

Yerdelen-Damar, Sevda; Elby, Andrew; Eryilmaz, Ali

2012-01-01

This study explored how researchers' views about the form of students' epistemologies influence how the researchers develop and refine surveys and how they interpret survey results. After running standard statistical analyses on 505 physics students' responses to the Turkish version of the Maryland Physics Expectations-II survey, probing students'…

The effect of somatic cell count data adjustment and interpretation, as outlined in European Union legislation, on herd eligibility to supply raw milk for processing of dairy products.

PubMed

More, S J; Clegg, T A; Lynch, P J; O'Grady, L

2013-06-01

Somatic cell count (SCC) limits are a key component of national and international regulation for milk quality. As yet, very limited work has been published on SCC regulatory standards, including on the effect of different approaches to SCC data adjustment and interpretation. This study examines the effect of SCC data adjustment and interpretation, as outlined in current European Union (EU) legislation, on herd eligibility to supply raw milk for processing of dairy products for human consumption, using Irish data for illustration. The study used Irish milk-recording data as a proxy for bulk tank SCC (BTSCC) data, to calculate an unadjusted monthly SCC value for each herd during each month of participation. Subsequently, 4 data adjustments were applied, as outlined in EU and national legislation: seasonal adjustment; 3-mo rolling geometric average, without accounting for a break in the supply; 3-mo rolling geometric average, after accounting for a break in the supply; and seasonal adjustment and 3-mo rolling geometric average combined, after accounting for a break in the supply. Analyses were conducted to examine the effect, during the period from 2004 to 2010, of data adjustment on the percentage of herds with herd SCC >400,000 cells/mL. In all, 4 interpretation scenarios, incorporating different data adjustment combinations, were used to estimate herd eligibility (compliant, under warning, or suspended, as defined by legislation) to supply raw milk for processing. The 4 methods of data adjustment each led to a sizable reduction (6.7, 5.0, 5.3, and 11.1 percentage points, respectively, compared with the unadjusted data) in the percentage of herds exceeding a herd SCC of 400,000 cells/mL. Herd eligibility varied by interpretation scenarios, in particular those incorporating seasonal adjustment. The study provides new perspectives on the effect of data adjustment on herd SCC and of interpretation scenarios on herd eligibility. The results provide an illustrative, rather than definitive, picture of this effect, as national authorities use BTSCC data when determining herd eligibility, whereas this study was conducted using milk-recording data as a proxy. Some aspects of the primary EU legislation are unclear, which may lead to differences in interpretation and application. The potential impact of data adjustment and milk purchaser pricing on farm-level mastitis control in Ireland is considered. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Explaining Support Vector Machines: A Color Based Nomogram

PubMed Central

Van Belle, Vanya; Van Calster, Ben; Van Huffel, Sabine; Suykens, Johan A. K.; Lisboa, Paulo

2016-01-01

Problem setting Support vector machines (SVMs) are very popular tools for classification, regression and other problems. Due to the large choice of kernels they can be applied with, a large variety of data can be analysed using these tools. Machine learning thanks its popularity to the good performance of the resulting models. However, interpreting the models is far from obvious, especially when non-linear kernels are used. Hence, the methods are used as black boxes. As a consequence, the use of SVMs is less supported in areas where interpretability is important and where people are held responsible for the decisions made by models. Objective In this work, we investigate whether SVMs using linear, polynomial and RBF kernels can be explained such that interpretations for model-based decisions can be provided. We further indicate when SVMs can be explained and in which situations interpretation of SVMs is (hitherto) not possible. Here, explainability is defined as the ability to produce the final decision based on a sum of contributions which depend on one single or at most two input variables. Results Our experiments on simulated and real-life data show that explainability of an SVM depends on the chosen parameter values (degree of polynomial kernel, width of RBF kernel and regularization constant). When several combinations of parameter values yield the same cross-validation performance, combinations with a lower polynomial degree or a larger kernel width have a higher chance of being explainable. Conclusions This work summarizes SVM classifiers obtained with linear, polynomial and RBF kernels in a single plot. Linear and polynomial kernels up to the second degree are represented exactly. For other kernels an indication of the reliability of the approximation is presented. The complete methodology is available as an R package and two apps and a movie are provided to illustrate the possibilities offered by the method. PMID:27723811

The implementation of an AR (augmented reality) approach to support mammographic interpretation training: an initial feasibility study

NASA Astrophysics Data System (ADS)

Tang, Qiang; Chen, Yan; Gale, Alastair G.

2017-03-01

Appropriate feedback plays an important role in optimising mammographic interpretation training whilst also ensuring good interpretation performance. The traditional keyboard, mouse and workstation technical approach has a critical limitation in providing supplementary image-related information and providing complex feedback in real time. Augmented Reality (AR) provides a possible superior approach in this situation, as feedback can be provided directly overlaying the displayed mammographic images so making a generic approach which can also be vendor neutral. In this study, radiological feedback was dynamically remapped virtually into the real world, using perspective transformation, in order to provide a richer user experience in mammographic interpretation training. This is an initial attempt of an AR approach to dynamically superimpose pre-defined feedback information of a DICOM image on top of a radiologist's view, whilst the radiologist is examining images on a clinical workstation. The study demonstrates the feasibility of the approach, although there are limitations on interactive operations which are due to the hardware used. The results of this fully functional approach provide appropriate feedback/image correspondence in a simulated mammographic interpretation environment. Thus, it is argued that employing AR is a feasible way to provide rich feedback in the delivery of mammographic interpretation training.

Understanding genetic variation - the value of systems biology.

PubMed

Hütt, Marc-Thorsten

2014-04-01

Pharmacology is currently transformed by the vast amounts of genome-associated information available for system-level interpretation. Here I review the potential of systems biology to facilitate this interpretation, thus paving the way for the emerging field of systems pharmacology. In particular, I will show how gene regulatory and metabolic networks can serve as a framework for interpreting high throughput data and as an interface to detailed dynamical models. In addition to the established connectivity analyses of effective networks, I suggest here to also analyze higher order architectural properties of effective networks. © 2013 The British Pharmacological Society.

Differences in reporting of analyses in internal company documents versus published trial reports: comparisons in industry-sponsored trials in off-label uses of gabapentin.

PubMed

Vedula, S Swaroop; Li, Tianjing; Dickersin, Kay

2013-01-01

Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our objective was to compare the description of types of analyses and criteria for including participants in the publication (i.e., what was reported) with descriptions in the corresponding internal company documents (i.e., what was planned and what was done). Trials were for off-label uses of gabapentin sponsored by Pfizer and Parke-Davis, and documents were obtained through litigation. For each trial, we compared internal company documents (protocols, statistical analysis plans, and research reports, all unpublished), with publications. One author extracted data and another verified, with a third person verifying discordant items and a sample of the rest. Extracted data included the number of participants randomized and analyzed for efficacy, and types of analyses for efficacy and safety and their definitions (i.e., criteria for including participants in each type of analysis). We identified 21 trials, 11 of which were published randomized controlled trials, and that provided the documents needed for planned comparisons. For three trials, there was disagreement on the number of randomized participants between the research report and publication. Seven types of efficacy analyses were described in the protocols, statistical analysis plans, and publications, including ITT and six others. The protocol or publication described ITT using six different definitions, resulting in frequent disagreements between the two documents (i.e., different numbers of participants were included in the analyses). Descriptions of analyses conducted did not agree between internal company documents and what was publicly reported. Internal company documents provide extensive documentation of methods planned and used, and trial findings, and should be publicly accessible. Reporting standards for randomized controlled trials should recommend transparent descriptions and definitions of analyses performed and which study participants are excluded.

Using software agents to preserve individual health data confidentiality in micro-scale geographical analyses.

PubMed

Kamel Boulos, Maged N; Cai, Qiang; Padget, Julian A; Rushton, Gerard

2006-04-01

Confidentiality constraints often preclude the release of disaggregate data about individuals, which limits the types and accuracy of the results of geographical health analyses that could be done. Access to individually geocoded (disaggregate) data often involves lengthy and cumbersome procedures through review boards and committees for approval (and sometimes is not possible). Moreover, current data confidentiality-preserving solutions compatible with fine-level spatial analyses either lack flexibility or yield less than optimal results (because of confidentiality-preserving changes they introduce to disaggregate data), or both. In this paper, we present a simulation case study to illustrate how some analyses cannot be (or will suffer if) done on aggregate data. We then quickly review some existing data confidentiality-preserving techniques, and move on to explore a solution based on software agents with the potential of providing flexible, controlled (software-only) access to unmodified confidential disaggregate data and returning only results that do not expose any person-identifiable details. The solution is thus appropriate for micro-scale geographical analyses where no person-identifiable details are required in the final results (i.e., only aggregate results are needed). Our proposed software agent technique also enables post-coordinated analyses to be designed and carried out on the confidential database(s), as needed, compared to a more conventional solution based on the Web Services model that would only support a rigid, pre-coordinated (pre-determined) and rather limited set of analyses. The paper also provides an exploratory discussion of mobility, security, and trust issues associated with software agents, as well as possible directions/solutions to address these issues, including the use of virtual organizations. Successful partnerships between stakeholder organizations, proper collaboration agreements, clear policies, and unambiguous interpretations of laws and regulations are also much needed to support and ensure the success of any technological solution.

Limited English proficient Hmong- and Spanish-speaking patients' perceptions of the quality of interpreter services.

PubMed

Lor, Maichou; Xiong, Phia; Schwei, Rebecca J; Bowers, Barbara J; Jacobs, Elizabeth A

2016-02-01

Language barriers are a large and growing problem for patients in the US and around the world. Interpreter services are a standard solution for addressing language barriers and most research has focused on utilization of interpreter services and their effect on health outcomes for patients who do not speak the same language as their healthcare providers including nurses. However, there is limited research on patients' perceptions of these interpreter services. To examine Hmong- and Spanish-speaking patients' perceptions of interpreter service quality in the context of receiving cancer preventive services. Twenty limited English proficient Hmong (n=10) and Spanish-speaking participants (n=10) ranging in age from 33 to 75 years were interviewed by two bilingual researchers in a Midwestern state. Interviews were audio taped, transcribed verbatim, and translated into English. Analysis was done using conventional content analysis. The two groups shared perceptions about the quality of interpreter services as variable along three dimensions. Specifically, both groups evaluated quality of interpreters based on the interpreters' ability to provide: (a) literal interpretation, (b) cultural interpretation, and (c) emotional interpretation during the health care encounter. The groups differed, however, on how they described the consequences of poor interpretation quality. Hmong participants described how poor quality interpretation could lead to: (a) poor interpersonal relationships among patients, providers, and interpreters, (b) inability of patients to follow through with treatment plans, and (c) emotional distress for patients. Our study highlights the fact that patients are discerning consumers of interpreter services; and could be effective partners in efforts to reform and enhance interpreter services. Copyright © 2015 Elsevier Ltd. All rights reserved.

The property of the Japanese version of the Recovery Knowledge Inventory (RKI) among mental health service providers: a cross sectional study.

PubMed

Chiba, Rie; Umeda, Maki; Goto, Kyohei; Miyamoto, Yuki; Yamaguchi, Sosei; Kawakami, Norito

2017-01-01

The Recovery Knowledge Inventory (RKI) is one of the influential scales to assess knowledge and attitude toward recovery-oriented practices among mental health service providers. In the present study, we aimed to develop a Japanese version of RKI and examine the validity and reliability. We translated RKI into Japanese by reference to the guidelines for translating and adapting psychometric scales. A cross-sectional questionnaire survey was conducted with mental health service providers. Of a total of 475 eligible professionals, we used data from the 299 participants without missing value for the analyses (valid response rate = 62.9%). The questionnaire included Japanese RKI, Recovery Attitudes Questionnaire, The positive attitudes scale, and Japanese-language version of the Social Distance Scale. To examine the factorial validity of RKI, explanatory factor analysis and confirmatory factor analysis was employed. Convergent validity was assessed by calculating Pearson's correlation coefficients between the total RKI score and the scores for the other three scales. We also calculated Cronbach's α coefficients for the total score and for each domain of RKI to assess internal consistency reliability. The participants' mean age was 40.4 years and 30.4% were men. 20-item RKI did not provide any adequate or interpretable factor solutions at any number of factors by EFAs. Thus four items (#1, 4, 5, and 13) were subsequently eliminated in stages, then 16-item RKI was employed as a consequence for further analyses. EFA with four factor structures yielded marginally interpretable constitution. Each factor represented the knowledge regarding psychiatric symptoms and recovery; knowledge about the recovery process; the understanding of what is important for recovery; and the understanding of the challenges and responsibility in recovery, respectively. Subsequent CFA suggested good fit to the data. Good convergent validity and understandable internal consistency reliability were also observed. The Japanese 16-item RKI revealed reasonable factorial validity, good convergent validity, and understandable internal consistency reliability among mental health professionals. Japanese cultural settings seemed to influence the four-factor structure in the present study. It can be used for future study in Japan, while future large-scale research is required to ensure robust verification.

What dementia reveals about proverb interpretation and its neuroanatomical correlates.

PubMed

Kaiser, Natalie C; Lee, Grace J; Lu, Po H; Mather, Michelle J; Shapira, Jill; Jimenez, Elvira; Thompson, Paul M; Mendez, Mario F

2013-08-01

Neuropsychologists frequently include proverb interpretation as a measure of executive abilities. A concrete interpretation of proverbs, however, may reflect semantic impairments from anterior temporal lobes, rather than executive dysfunction from frontal lobes. The investigation of proverb interpretation among patients with different dementias with varying degrees of temporal and frontal dysfunction may clarify the underlying brain-behavior mechanisms for abstraction from proverbs. We propose that patients with behavioral variant frontotemporal dementia (bvFTD), who are characteristically more impaired on proverb interpretation than those with Alzheimer's disease (AD), are disproportionately impaired because of anterior temporal-mediated semantic deficits. Eleven patients with bvFTD and 10 with AD completed the Delis-Kaplan Executive Function System (D-KEFS) Proverbs Test and a series of neuropsychological measures of executive and semantic functions. The analysis included both raw and age-adjusted normed data for multiple choice responses on the D-KEFS Proverbs Test using independent samples t-tests. Tensor-based morphometry (TBM) applied to 3D T1-weighted MRI scans mapped the association between regional brain volume and proverb performance. Computations of mean Jacobian values within select regions of interest provided a numeric summary of regional volume, and voxel-wise regression yielded 3D statistical maps of the association between tissue volume and proverb scores. The patients with bvFTD were significantly worse than those with AD in proverb interpretation. The worse performance of the bvFTD patients involved a greater number of concrete responses to common, familiar proverbs, but not to uncommon, unfamiliar ones. These concrete responses to common proverbs correlated with semantic measures, whereas concrete responses to uncommon proverbs correlated with executive functions. After controlling for dementia diagnosis, TBM analyses indicated significant correlations between impaired proverb interpretation and the anterior temporal lobe region (left>right). Among two dementia groups, those with bvFTD, demonstrated a greater number of concrete responses to common proverbs compared to those with AD, and this performance correlated with semantic deficits and the volume of the left anterior lobe, the hub of semantic knowledge. The findings of this study suggest that common proverb interpretation is greatly influenced by semantic dysfunction and that the use of proverbs for testing executive functions needs to include the interpretation of unfamiliar proverbs. Published by Elsevier Ltd.

Interpreting sulci on hominin endocasts: old hypotheses and new findings

PubMed Central

Falk, Dean

2014-01-01

Paleoneurologists analyze internal casts (endocasts) of fossilized braincases, which provide information about the size, shape and, to a limited degree, sulcal patterns reproduced from impressions left by the surface of the brain. When interpreted in light of comparative data from the brains of living apes and humans, sulcal patterns reproduced on hominin endocasts provide important information for studying the evolution of the cerebral cortex and cognition in human ancestors. Here, new evidence is discussed for the evolution of sulcal patterns associated with cortical reorganization in three parts of the hominin brain: (1) the parietotemporo-occipital association cortex, (2) Broca's speech area, and (3) dorsolateral prefrontal association cortex. Of the three regions, the evidence regarding the last is the clearest. Compared to great apes, Australopithecus endocasts reproduce a clear middle frontal sulcus in the dorsolateral prefrontal cortex that is derived toward the human condition. This finding is consistent with data from comparative cytoarchitectural studies of ape and human brains as well as shape analyses of australopithecine endocasts. The comparative and direct evidence for all three regions suggests that hominin brain reorganization was underway by at least the time of Australopithecus africanus (~2.5 to 3.0 mya), despite the ape-sized brains of these hominins, and that it entailed expansion of both rostral and caudal association cortices. PMID:24822043

Airborne electromagnetic mapping of the base of aquifer in areas of western Nebraska

USGS Publications Warehouse

Abraham, Jared D.; Cannia, James C.; Bedrosian, Paul A.; Johnson, Michaela R.; Ball, Lyndsay B.; Sibray, Steven S.

2012-01-01

Airborne geophysical surveys of selected areas of the North and South Platte River valleys of Nebraska, including Lodgepole Creek valley, collected data to map aquifers and bedrock topography and thus improve the understanding of groundwater - surface-water relationships to be used in water-management decisions. Frequency-domain helicopter electromagnetic surveys, using a unique survey flight-line design, collected resistivity data that can be related to lithologic information for refinement of groundwater model inputs. To make the geophysical data useful to multidimensional groundwater models, numerical inversion converted measured data into a depth-dependent subsurface resistivity model. The inverted resistivity model, along with sensitivity analyses and test-hole information, is used to identify hydrogeologic features such as bedrock highs and paleochannels, to improve estimates of groundwater storage. The two- and three-dimensional interpretations provide the groundwater modeler with a high-resolution hydrogeologic framework and a quantitative estimate of framework uncertainty. The new hydrogeologic frameworks improve understanding of the flow-path orientation by refining the location of paleochannels and associated base of aquifer highs. These interpretations provide resource managers high-resolution hydrogeologic frameworks and quantitative estimates of framework uncertainty. The improved base of aquifer configuration represents the hydrogeology at a level of detail not achievable with previously available data.

Multiattribute evaluation of regional cotton variety trials.

PubMed

Basford, K E; Kroonenberg, P M; Delacy, I H; Lawrence, P K

1990-02-01

The Australian Cotton Cultivar Trials (ACCT) are designed to investigate various cotton [Gossypium hirsutum (L.)] lines in several locations in New South Wales and Queensland each year. If these lines are to be assessed by the simultaneous use of yield and lint quality data, then a multivariate technique applicable to three-way data is desirable. Two such techniques, the mixture maximum likelihood method of clustering and three-mode principal component analysis, are described and used to analyze these data. Applied together, the methods enhance each other's usefulness in interpreting the information on the line response patterns across the locations. The methods provide a good integration of the responses across environments of the entries for the different attributes in the trials. For instance, using yield as the sole criterion, the excellence of the namcala and coker group for quality is overlooked. The analyses point to a decision in favor of either high yields of moderate to good quality lint or moderate yield but superior lint quality. The decisions indicated by the methods confirmed the selections made by the plant breeders. The procedures provide a less subjective, relatively easy to apply and interpret analytical method of describing the patterns of performance and associations in complex multiattribute and multilocation trials. This should lead to more efficient selection among lines in such trials.

Threshold concepts in prosthetics.

PubMed

Hill, Sophie

2017-12-01

Curriculum documents identify key concepts within learning prosthetics. Threshold concepts provide an alternative way of viewing the curriculum, focussing on the ways of thinking and practicing within prosthetics. Threshold concepts can be described as an opening to a different way of viewing a concept. This article forms part of a larger study exploring what students and staff experience as difficult in learning about prosthetics. To explore possible threshold concepts within prosthetics. Qualitative, interpretative phenomenological analysis. Data from 18 students and 8 staff at two universities with undergraduate prosthetics and orthotics programmes were generated through interviews and questionnaires. The data were analysed using an interpretative phenomenological analysis approach. Three possible threshold concepts arose from the data: 'how we walk', 'learning to talk' and 'considering the person'. Three potential threshold concepts in prosthetics are suggested with possible implications for prosthetics education. These possible threshold concepts involve changes in both conceptual and ontological knowledge, integrating into the persona of the individual. This integration occurs through the development of memories associated with procedural concepts that combine with disciplinary concepts. Considering the prosthetics curriculum through the lens of threshold concepts enables a focus on how students learn to become prosthetists. Clinical relevance This study provides new insights into how prosthetists learn. This has implications for curriculum design in prosthetics education.

The mortality reducing effect of aspirin in colorectal cancer patients: Interpreting the evidence.

PubMed

Frouws, Martine A; van Herk-Sukel, Myrthe P P; Maas, Huub A; Van de Velde, Cornelis J H; Portielje, Johanneke E A; Liefers, Gerrit-Jan; Bastiaannet, Esther

2017-04-01

In 1971 the first study appeared that suggested a relationship between aspirin and cancer. Currently publications on the subject of aspirin and cancer are numerous, with both a beneficial effect of aspirin on cancer incidence and a beneficial effect on cancer survival. This review focusses on the relation between the use of aspirin and improved survival in colorectal cancer patients. Various study designs have been used, with the main part being observational studies and post hoc meta-analyses of cancer outcomes in cardiovascular prevention trials. The results of these studies are unambiguously pointing towards an effect of aspirin on colorectal cancer survival, and several randomised controlled trials are currently ongoing. Some clinicians feel that the current evidence is conclusive and that the time has come for aspirin to be prescribed as adjuvant therapy. However, until this review, not much attention has been paid to the specific types of bias associated with these studies. One of these biases is confounding by indication, because aspirin is indicated for patients as secondary prevention for cardiovascular disease. This review aims to provide perspective on these biases and provide tools for the interpretation of the current evidence. Albeit promising, the current evidence is not sufficient to already prescribe aspirin as adjuvant therapy for colorectal cancer. Copyright © 2016 Elsevier Ltd. All rights reserved.

Basic Interpretation of EKG's. N203.

ERIC Educational Resources Information Center

Hall, Laura T.

A description is provided of an associate degree in nursing science course, "Rapid Interpretation of Electrocardiograms (EKG's)," designed to emphasize the nurse's role in the interpretation of the basic EKG and the medical interventions necessary to treat arrythmias. The first section of the course description provides information on…

Functional Organization of the Action Observation Network in Autism: A Graph Theory Approach

PubMed Central

Alaerts, Kaat; Geerlings, Franca; Herremans, Lynn; Swinnen, Stephan P.; Verhoeven, Judith; Sunaert, Stefan; Wenderoth, Nicole

2015-01-01

Background The ability to recognize, understand and interpret other’s actions and emotions has been linked to the mirror system or action-observation-network (AON). Although variations in these abilities are prevalent in the neuro-typical population, persons diagnosed with autism spectrum disorders (ASD) have deficits in the social domain and exhibit alterations in this neural network. Method Here, we examined functional network properties of the AON using graph theory measures and region-to-region functional connectivity analyses of resting-state fMRI-data from adolescents and young adults with ASD and typical controls (TC). Results Overall, our graph theory analyses provided convergent evidence that the network integrity of the AON is altered in ASD, and that reductions in network efficiency relate to reductions in overall network density (i.e., decreased overall connection strength). Compared to TC, individuals with ASD showed significant reductions in network efficiency and increased shortest path lengths and centrality. Importantly, when adjusting for overall differences in network density between ASD and TC groups, participants with ASD continued to display reductions in network integrity, suggesting that also network-level organizational properties of the AON are altered in ASD. Conclusion While differences in empirical connectivity contributed to reductions in network integrity, graph theoretical analyses provided indications that also changes in the high-level network organization reduced integrity of the AON. PMID:26317222

Age of UHP metamorphism in the Western Mediterranean: Insight from rutile and minute zircon inclusions in a diamond-bearing garnet megacryst (Edough Massif, NE Algeria)

NASA Astrophysics Data System (ADS)

Bruguier, Olivier; Bosch, Delphine; Caby, Renaud; Vitale-Brovarone, Alberto; Fernandez, Laure; Hammor, Dalila; Laouar, Rabah; Ouabadi, Aziouz; Abdallah, Nachida; Mechati, Mehdi

2017-09-01

Diamond-bearing UHP metamorphic rocks witness for subduction of lithospheric slabs into the mantle and their return to shallow levels. In this study we present U-Pb and trace elements analyses of zircon and rutile inclusions from a diamond-bearing garnet megacryst collected in a mélange unit exposed on the northern margin of Africa (Edough Massif, NE Algeria). Large rutile crystals (up to 300 μm in size) analyzed in situ provide a U-Pb age of 32.4 ± 3.3 Ma interpreted as dating the prograde to peak subduction stage of the mafic protolith. Trace element analyses of minute zircons (≤30 μm) indicate that they formed in equilibrium with the garnet megacryst at a temperature of 740-810 °C, most likely during HP retrograde metamorphism. U-Pb analyses provide a significantly younger age of 20.7 ± 2.3 Ma attributed to exhumation of the UHP units. This study allows bracketing the age of UHP metamorphism in the Western Mediterranean Orogen to the Oligocene/early Miocene, thus unambiguously relating UHP metamorphism to the Alpine history. Exhumation of these UHP units is coeval with the counterclockwise rotation of the Corsica-Sardinia block and most likely resulted from subduction rollback that was driven by slab pull.

The human alimentary tract transfer and body retention of environmental polonium-210.

PubMed

Hunt, G J; Rumney, H S

2007-12-01

This paper presents the results of a 4 year study to investigate the human alimentary tract transfer factor (f(A) value) and body retention of 210 Po in shellfish. In the first 3 years, mussels (Mytilus edulis L.), cockles (Cerastoderma edule L.) and brown meat from crab (Cancer pagurus L.) were successively studied. In each year five volunteers (from a pool of seven) ate a suitable portion of the shellfish and provided 24 h samples of excreta usually for 3 days before and for at least 7 days during and after eating. Subsamples of shellfish were analysed to determine the intakes of 210 Po. Faeces were analysed and the data used to assess apparent fA values. Urine samples were analysed in the mussel and crab studies to provide urinary excretion parameters. Pb-210 was also analysed during the mussel study; the levels were low, leading to large uncertainties, but confirming the negligible effect of radioactive decay to its granddaughter 210 Po in the main study. In the fourth year, larger samples of brown crab meat were eaten by five volunteers and faecal samples were taken at suitable times over periods of up to 43 days to study body retention of 210 Po. The first approximately 7 days provided additional data on fA values. Pooled results for the apparent fA for the whole study lay in the range 0.15-0.65 with a mean of 0.46; corrections for endogenous excretion suggest a true fA value of approximately 0.51, supporting the value of 0.5 currently used by the International Commission on Radiological Protection (ICRP). The retention data suggest a biological half-time of about 40 days, in broad consistency with the 50 days currently used by the ICRP. Thus there is no strong evidence from this study suggesting a change in dose coefficient for 210 Po. Full experimental data are provided to allow independent further interpretation.

Rates and Predictors of Professional Interpreting Provision for Patients With Limited English Proficiency in the Emergency Department and Inpatient Ward

PubMed Central

Ryan, Jennifer; Abbato, Samantha; Greer, Ristan; Vayne-Bossert, Petra; Good, Phillip

2017-01-01

The provision of professional interpreting services in the hospital setting decreases communication errors of clinical significance and improves clinical outcomes. A retrospective audit was conducted at a tertiary referral adult hospital in Brisbane, Australia. Of 20 563 admissions of patients presenting to the hospital emergency department (ED) and admitted to a ward during 2013-2014, 582 (2.8%) were identified as requiring interpreting services. In all, 19.8% of admissions were provided professional interpreting services in the ED, and 26.1% were provided on the ward. Patients were more likely to receive interpreting services in the ED if they were younger, spoke an Asian language, or used sign language. On the wards, using sign language was associated with 3 times odds of being provided an interpreter compared with other languages spoken. Characteristics of patients including their age and type of language spoken influence the clinician’s decision to engage a professional interpreter in both the ED and inpatient ward. PMID:29144184

Introduction to bifactor polytomous item response theory analysis.

PubMed

Toland, Michael D; Sulis, Isabella; Giambona, Francesca; Porcu, Mariano; Campbell, Jonathan M

2017-02-01

A bifactor item response theory model can be used to aid in the interpretation of the dimensionality of a multifaceted questionnaire that assumes continuous latent variables underlying the propensity to respond to items. This model can be used to describe the locations of people on a general continuous latent variable as well as on continuous orthogonal specific traits that characterize responses to groups of items. The bifactor graded response (bifac-GR) model is presented in contrast to a correlated traits (or multidimensional GR model) and unidimensional GR model. Bifac-GR model specification, assumptions, estimation, and interpretation are demonstrated with a reanalysis of data (Campbell, 2008) on the Shared Activities Questionnaire. We also show the importance of marginalizing the slopes for interpretation purposes and we extend the concept to the interpretation of the information function. To go along with the illustrative example analyses, we have made available supplementary files that include command file (syntax) examples and outputs from flexMIRT, IRTPRO, R, Mplus, and STATA. Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j.jsp.2016.11.001. Data needed to reproduce analyses in this article are available as supplemental materials (online only) in the Appendix of this article. Copyright © 2016 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

Understanding and Using the Fermi Science Tools

NASA Astrophysics Data System (ADS)

Asercion, Joseph

2018-01-01

The Fermi Science Support Center (FSSC) provides information, documentation, and tools for the analysis of Fermi science data, including both the Large-Area Telescope (LAT) and the Gamma-ray Burst Monitor (GBM). Source and binary versions of the Fermi Science Tools can be downloaded from the FSSC website, and are supported on multiple platforms. An overview document, the Cicerone, provides details of the Fermi mission, the science instruments and their response functions, the science data preparation and analysis process, and interpretation of the results. Analysis Threads and a reference manual available on the FSSC website provide the user with step-by-step instructions for many different types of data analysis: point source analysis - generating maps, spectra, and light curves, pulsar timing analysis, source identification, and the use of python for scripting customized analysis chains. We present an overview of the structure of the Fermi science tools and documentation, and how to acquire them. We also provide examples of standard analyses, including tips and tricks for improving Fermi science analysis.

38 CFR 21.152 - Interpreter service for the hearing impaired.

Code of Federal Regulations, 2010 CFR

2010-07-01

... development and pursuit of a rehabilitation program. This service will be provided if: (1) A VA physician... determines that the veteran: (i) Can benefit from language and speech training; and (ii) Agrees to undertake language and speech training. (b) Periods during which interpreter service may be provided. Interpreter...

Limited English proficient Hmong- and Spanish-speaking patients’ perceptions of the quality of interpreter services

PubMed Central

Lor, Maichou; Xiong, Phia; Schweia, Rebecca J.; Bowers, Barbara; Jacobs, Elizabeth A.

2015-01-01

Background Language barriers are a large and growing problem for patients in the U.S. and around the world. Interpreter services are a standard solution for addressing language barriers and most research has focused on utilization of interpreter services and their effect on health outcomes for patients who do not speak the same language as their healthcare providers including nurses. However, there is limited research on patients’ perceptions of these interpreter services. Objective To examine Hmong- and Spanish-speaking patients’ perceptions of interpreter service quality in the context of receiving cancer preventive services. Methods Twenty limited English proficient Hmong (n=10) and Spanish-speaking participants (N=10) ranging in age from 33 to 75 years were interviewed by two bilingual researchers in a Midwestern state. Interviews were audio taped, transcribed verbatim, and translated into English. Analysis was done using conventional content analysis. Results The two groups shared perceptions about the quality of interpreter services as variable along three dimensions. Specifically, both groups evaluated quality of interpreters based on the interpreters’ ability to provide: (a) literal interpretation, (b) cultural interpretation, and (c) emotional interpretation during the health care encounter. The groups differed, however, on how they described the consequences of poor interpretation quality. Hmong participants described how poor quality interpretation could lead to: (a) poor interpersonal relationships among patients, providers, and interpreters, (b) inability of patients to follow through with treatment plans, and (c) emotional distress for patients. Conclusions Our study highlights the fact that patients are discerning consumers of interpreter services; and could be effective partners in efforts to reform and enhance interpreter services. PMID:25865517

Multi-instrument data analysis for interpretation of the Martian North polar layered deposits

NASA Astrophysics Data System (ADS)

Mirino, Melissa; Sefton-Nash, Elliot; Witasse, Olivier; Frigeri, Alessandro

2017-04-01

The Martian polar caps have engendered substantial study due to their spiral morphology, layered structure and the seasonal variability in thickness of the uppermost H2O and CO2 ice layers. We demonstrate a multi-instrument study of exposed and buried north polar layers using data from ESA's Mars Express (MEx) and NASA's Mars Reconnaissance Orbiter (MRO) missions. We perform analysis of high resolution images from MRO's HiRISE, which provide textural and morphological information about surface features larger than 0.3m, with NIR hyperspectral data from MRO CRISM, which allows study of surface mineralogy at a maximum resolution of 18 m/pixel. Stereo-derived topography is provided by MEx's HRSC. Together with these surficial observations we interpret radargrams from MRO SHARAD to obtain information about layered structures at a horizontal resolution between 0.3 and 3 kilometers and a free-space vertical resolution of 15 meters (vertical resolution depends on the dielectric properties of the medium). This combination of datasets allows us to attempt to correlate polar layering, made visible by dielectric interfaces between beds, with surface mineralogies and structures outcropping at specific stratigraphic levels. We analyse two opposite areas of the north polar cap with the intention to characterise in multiple datasets each geologic unit identified in the north polar cap's stratigraphy (mapped by e.g. [1]). We selected deposits observed in Chasma Boreale and Olympia Cavi because these areas allow us to observe and map strata at opposing sides of the north polar cap. Using the CRISM Analysis Tool and spectral summary parameters [2] we map the spectral characteristics of the two areas that show H2O and CO2 ice layering exposed on polar scarps. Through spatial-registration in a GIS with HRSC topography and HiRISE imagery we assess the mineralogical and morphological characteristics of exposed layers. In order to constrain the cross section between the two selected localities we choose SHARAD radargrams that most closely align with the transect between the sites. We interpret sub-horizontal features to be due to dielectric interfaces involving the deposits analysed. Our interpretation of radargrams in the context of compositional and structural constraints, from areas where pertinent beds outcrop, illustrates how joint analysis of surface and sub-surface data can benefit geological interpretation of planetary surfaces and subsurfaces. This technique applied to Mars' north polar layered deposits may offer additional constraint on morphology of internal layering resulting from seasonal deposition/sublimation cycles over varying obliquity [3]. References: [1] Tanaka et al. (2008), Icarus, 196, p. 318-358, doi:10.1016/j.icarus.2008.01.021. [2] Viviano-Beck et al. (2014), J. Geophys. Res. Planets, 119, p. 1403-1431, doi:10.1002/2014JE004627..[3] Putzig et al. (2009), Icarus, 204, p. 443-457, doi:10.1016/j.icarus.2009.07.034.

Creating a Meeting Point of Understanding: Interpreters' Experiences in Swedish Childhood Cancer Care.

PubMed

Granhagen Jungner, Johanna; Tiselius, Elisabet; Lützén, Kim; Blomgren, Klas; Pergert, Pernilla

2016-01-01

Children and families with a foreign background and limited Swedish proficiency have to communicate through interpreters in childhood cancer care centers in Sweden. Interpreter-mediated events deal with many difficulties that potentially hinder the transfer of information. The purpose of our study was to explore interpreters' experiences of interpreting between health care staff and limited Swedish proficiency patients/families in childhood cancer care. Using purposive samples, we interviewed 11 interpreters individually. The interviews were analyzed using qualitative content analysis. Analyses of the data resulted in the main theme of creating a meeting point of understanding, constructed from 3 subthemes: balancing between cultures, bridging the gaps of knowledge, and balancing between compassion and professionalism. Our result shows that in order to create a sustainable meeting point of understanding, it is necessary to explain both the context and cultural differences. These results suggest that the responsibility for information transfer lies with both the health care profession and the interpreters. Tools have to be developed for both parties to contribute to creating the meeting point of understanding. © 2015 by Association of Pediatric Hematology/Oncology Nurses.

Spiritual Well-Being Scale Ethnic Differences between Caucasians and African-Americans: Follow Up Analyses.

ERIC Educational Resources Information Center

Miller, Geri; Gridley, Betty; Fleming, Willie

This follow up study is in response to Miller, Fleming, and Brown-Andersons (1998) study of ethnic differences between Caucasians and African-Americans where the authors suggested that the Spiritual Well-Being (SWB) Scale may need to be interpreted differently depending on ethnicity. In this study, confirmatory factor analyses were conducted for…

Are Different Students Expected to Learn Norms Differently in the Mathematics Classroom?

ERIC Educational Resources Information Center

Planas, Nuria; Gorgorio, Nuria

2004-01-01

We analyse social interactions during the first days of class in a secondary mathematics classroom (15 and 16-year-olds) with a high percentage of immigrant students. Our analyses show the co-existence of different models for both the interpretation and the use of classroom social norms and socio-mathematical norms. Valorising some behaviours over…

Comments on `A Cautionary Note on the Interpretation of EOFs'.

NASA Astrophysics Data System (ADS)

Behera, Swadhin K.; Rao, Suryachandra A.; Saji, Hameed N.; Yamagata, Toshio

2003-04-01

The misleading aspect of the statistical analyses used in Dommenget and Latif, which raises concerns on some of the reported climate modes, is demonstrated. Adopting simple statistical techniques, the physical existence of the Indian Ocean dipole mode is shown and then the limitations of varimax and regression analyses in capturing the climate mode are discussed.

Reporting Data with "Over-the-Counter" Data Analysis Supports Improves Educators' Data Analyses

ERIC Educational Resources Information Center

Rankin, Jenny Grant

2014-01-01

The benefits of making data-informed decisions to improve learning rely on educators correctly interpreting given data. Many educators routinely misinterpret data, even at districts with proactive support for data use. The tool most educators use for data analyses, which is an information technology data system or its reports, typically reports…

Geologist's Field Assistant: Developing Image and Spectral Analyses Algorithms for Remote Science Exploration

NASA Technical Reports Server (NTRS)

Gulick, V. C.; Morris, R. L.; Bishop, J.; Gazis, P.; Alena, R.; Sierhuis, M.

2002-01-01

We are developing science analyses algorithms to interface with a Geologist's Field Assistant device to allow robotic or human remote explorers to better sense their surroundings during limited surface excursions. Our algorithms will interpret spectral and imaging data obtained by various sensors. Additional information is contained in the original extended abstract.

The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses

PubMed Central

2010-01-01

Background Proton Magnetic Resonance (MR) Spectroscopy (MRS) is a widely available technique for those clinical centres equipped with MR scanners. Unlike the rest of MR-based techniques, MRS yields not images but spectra of metabolites in the tissues. In pathological situations, the MRS profile changes and this has been particularly described for brain tumours. However, radiologists are frequently not familiar to the interpretation of MRS data and for this reason, the usefulness of decision-support systems (DSS) in MRS data analysis has been explored. Results This work presents the INTERPRET DSS version 3.0, analysing the improvements made from its first release in 2002. Version 3.0 is aimed to be a program that 1st, can be easily used with any new case from any MR scanner manufacturer and 2nd, improves the initial analysis capabilities of the first version. The main improvements are an embedded database, user accounts, more diagnostic discrimination capabilities and the possibility to analyse data acquired under additional data acquisition conditions. Other improvements include a customisable graphical user interface (GUI). Most diagnostic problems included have been addressed through a pattern-recognition based approach, in which classifiers based on linear discriminant analysis (LDA) were trained and tested. Conclusions The INTERPRET DSS 3.0 allows radiologists, medical physicists, biochemists or, generally speaking, any person with a minimum knowledge of what an MR spectrum is, to enter their own SV raw data, acquired at 1.5 T, and to analyse them. The system is expected to help in the categorisation of MR Spectra from abnormal brain masses. PMID:21114820

Quantifying the Diversity and Similarity of Surgical Procedures Among Hospitals and Anesthesia Providers.

PubMed

Dexter, Franklin; Ledolter, Johannes; Hindman, Bradley J

2016-01-01

In this Statistical Grand Rounds, we review methods for the analysis of the diversity of procedures among hospitals, the activities among anesthesia providers, etc. We apply multiple methods and consider their relative reliability and usefulness for perioperative applications, including calculations of SEs. We also review methods for comparing the similarity of procedures among hospitals, activities among anesthesia providers, etc. We again apply multiple methods and consider their relative reliability and usefulness for perioperative applications. The applications include strategic analyses (e.g., hospital marketing) and human resource analytics (e.g., comparisons among providers). Measures of diversity of procedures and activities (e.g., Herfindahl and Gini-Simpson index) are used for quantification of each facility (hospital) or anesthesia provider, one at a time. Diversity can be thought of as a summary measure. Thus, if the diversity of procedures for 48 hospitals is studied, the diversity (and its SE) is being calculated for each hospital. Likewise, the effective numbers of common procedures at each hospital can be calculated (e.g., by using the exponential of the Shannon index). Measures of similarity are pairwise assessments. Thus, if quantifying the similarity of procedures among cases with a break or handoff versus cases without a break or handoff, a similarity index represents a correlation coefficient. There are several different measures of similarity, and we compare their features and applicability for perioperative data. We rely extensively on sensitivity analyses to interpret observed values of the similarity index.

Validation of the INCEPT: A Multisource Feedback Tool for Capturing Different Perspectives on Physicians' Professional Performance.

PubMed

van der Meulen, Mirja W; Boerebach, Benjamin C M; Smirnova, Alina; Heeneman, Sylvia; Oude Egbrink, Mirjam G A; van der Vleuten, Cees P M; Arah, Onyebuchi A; Lombarts, Kiki M J M H

2017-01-01

Multisource feedback (MSF) instruments are used to and must feasibly provide reliable and valid data on physicians' performance from multiple perspectives. The "INviting Co-workers to Evaluate Physicians Tool" (INCEPT) is a multisource feedback instrument used to evaluate physicians' professional performance as perceived by peers, residents, and coworkers. In this study, we report on the validity, reliability, and feasibility of the INCEPT. The performance of 218 physicians was assessed by 597 peers, 344 residents, and 822 coworkers. Using explorative and confirmatory factor analyses, multilevel regression analyses between narrative and numerical feedback, item-total correlations, interscale correlations, Cronbach's α and generalizability analyses, the psychometric qualities, and feasibility of the INCEPT were investigated. For all respondent groups, three factors were identified, although constructed slightly different: "professional attitude," "patient-centeredness," and "organization and (self)-management." Internal consistency was high for all constructs (Cronbach's α ≥ 0.84 and item-total correlations ≥ 0.52). Confirmatory factor analyses indicated acceptable to good fit. Further validity evidence was given by the associations between narrative and numerical feedback. For reliable total INCEPT scores, three peer, two resident and three coworker evaluations were needed; for subscale scores, evaluations of three peers, three residents and three to four coworkers were sufficient. The INCEPT instrument provides physicians performance feedback in a valid and reliable way. The number of evaluations to establish reliable scores is achievable in a regular clinical department. When interpreting feedback, physicians should consider that respondent groups' perceptions differ as indicated by the different item clustering per performance factor.

Lower Extremity Muscle Activity during Cycling in Adolescents with and without Cerebral Palsy

PubMed Central

Lauer, Richard T.; Johnston, Therese E.; Smith, Brian T.; Lee, Samuel C.K.

2008-01-01

Background In individuals with cerebral palsy (CP), adaptation and plasticity in the neuromuscular system can lead to detrimental changes affecting gait. Cycling may be an effective method to improve mobility. The biomechanics of cycling in adolescents with CP have been studied, but further analysis of the frequency and amplitude characteristics of the electromyographic (EMG) signals can assist with interpretation of the cycling kinematics. Methods Data were analyzed from ten adolescents with typical development (TD) (mean = 14.9 SD = 1.4 years) and ten adolescents with CP (mean = 15.6 SD = 1.8 years) as they cycled at two different cadences. Analyses of the lower extremity EMG signals involved frequency and amplitude analysis across the cycling revolution. Findings Examination of cycling cadence revealed that adolescents with CP had altered EMG characteristics in comparison to adolescents with typical development across the entire crank revolution for all muscles. Analyses of individual muscles indicated both inappropriate muscle activation and weakness. Interpretation A more comprehensive analysis of EMG activity has the potential to provide insight into how a task is accomplished. In this study, the control of the several muscles, especially the rectus femoris, was significantly different in adolescents with cerebral palsy. This, combined with muscle weakness, may have contributed to the observed deviations in joint kinematics. Interventions that increase muscle strength with feedback to the nervous system about appropriate activation timing may be beneficial to allow individuals with CP to cycle more efficiently. PMID:18082920

The link between autism and skills such as engineering, maths, physics and computing: a reply to Jarrold and Routh.

PubMed

Wheelwright, S; Baron-Cohen, S

2001-06-01

In the first edition of this journal, we published a paper reporting that fathers and grandfathers of children with autism were over-represented in the field of engineering. This result was interpreted as providing supporting evidence for the folk-psychology/folk-physics theory of autism. After carrying out further analyses on the same data, Jarrold and Routh found that fathers of children with autism were also over-represented in accountancy and science. They suggested that these results could either provide additional support for the folk-psychology/folk-physics theory or be accounted for by an over-representation of professionals amongst the fathers of children with autism. Here we present evidence that engineers are still over-represented among fathers of children with autism, even taking into account the professional bias.

The matching law: a tutorial for practitioners.

PubMed

Reed, Derek D; Kaplan, Brent A

2011-01-01

The application of the matching law has historically been limited to use as a quantitative measurement tool in the experimental analysis of behavior to describe temporally extended patterns of behavior-environment relations. In recent years, however, applications of the matching law have been translated to clinical settings and populations to gain a better understanding of how naturally-occurring events affect socially important behaviors. This tutorial provides a brief background of the conceptual foundations of matching, an overview of the various matching equations that have been used in research, and a description of how to interpret the data derived from these equations in the context of numerous examples of matching analyses conducted with socially important behavior. An appendix of resources is provided to direct readers to primary sources, as well as useful articles and books on the topic.

Analyzing gene expression data in mice with the Neuro Behavior Ontology.

PubMed

Hoehndorf, Robert; Hancock, John M; Hardy, Nigel W; Mallon, Ann-Marie; Schofield, Paul N; Gkoutos, Georgios V

2014-02-01

We have applied the Neuro Behavior Ontology (NBO), an ontology for the annotation of behavioral gene functions and behavioral phenotypes, to the annotation of more than 1,000 genes in the mouse that are known to play a role in behavior. These annotations can be explored by researchers interested in genes involved in particular behaviors and used computationally to provide insights into the behavioral phenotypes resulting from differences in gene expression. We developed the OntoFUNC tool and have applied it to enrichment analyses over the NBO to provide high-level behavioral interpretations of gene expression datasets. The resulting increase in the number of gene annotations facilitates the identification of behavioral or neurologic processes by assisting the formulation of hypotheses about the relationships between gene, processes, and phenotypic manifestations resulting from behavioral observations.

The Matching Law: A Tutorial for Practitioners

PubMed Central

Kaplan, Brent A

2011-01-01

The application of the matching law has historically been limited to use as a quantitative measurement tool in the experimental analysis of behavior to describe temporally extended patterns of behavior-environment relations. In recent years, however, applications of the matching law have been translated to clinical settings and populations to gain a better understanding of how naturally-occurring events affect socially important behaviors. This tutorial provides a brief background of the conceptual foundations of matching, an overview of the various matching equations that have been used in research, and a description of how to interpret the data derived from these equations in the context of numerous examples of matching analyses conducted with socially important behavior. An appendix of resources is provided to direct readers to primary sources, as well as useful articles and books on the topic. PMID:22649575

Interpreters, Interpreting, and the Study of Bilingualism.

ERIC Educational Resources Information Center

Valdes, Guadalupe; Angelelli, Claudia

2003-01-01

Discusses research on interpreting focused specifically on issues raised by this literature about the nature of bilingualism. Suggests research carried out on interpreting--while primarily produced with a professional audience in mind and concerned with improving the practice of interpreting--provides valuable insights about complex aspects of…

ETE: a python Environment for Tree Exploration.

PubMed

Huerta-Cepas, Jaime; Dopazo, Joaquín; Gabaldón, Toni

2010-01-13

Many bioinformatics analyses, ranging from gene clustering to phylogenetics, produce hierarchical trees as their main result. These are used to represent the relationships among different biological entities, thus facilitating their analysis and interpretation. A number of standalone programs are available that focus on tree visualization or that perform specific analyses on them. However, such applications are rarely suitable for large-scale surveys, in which a higher level of automation is required. Currently, many genome-wide analyses rely on tree-like data representation and hence there is a growing need for scalable tools to handle tree structures at large scale. Here we present the Environment for Tree Exploration (ETE), a python programming toolkit that assists in the automated manipulation, analysis and visualization of hierarchical trees. ETE libraries provide a broad set of tree handling options as well as specific methods to analyze phylogenetic and clustering trees. Among other features, ETE allows for the independent analysis of tree partitions, has support for the extended newick format, provides an integrated node annotation system and permits to link trees to external data such as multiple sequence alignments or numerical arrays. In addition, ETE implements a number of built-in analytical tools, including phylogeny-based orthology prediction and cluster validation techniques. Finally, ETE's programmable tree drawing engine can be used to automate the graphical rendering of trees with customized node-specific visualizations. ETE provides a complete set of methods to manipulate tree data structures that extends current functionality in other bioinformatic toolkits of a more general purpose. ETE is free software and can be downloaded from http://ete.cgenomics.org.

ETE: a python Environment for Tree Exploration

PubMed Central

2010-01-01

Background Many bioinformatics analyses, ranging from gene clustering to phylogenetics, produce hierarchical trees as their main result. These are used to represent the relationships among different biological entities, thus facilitating their analysis and interpretation. A number of standalone programs are available that focus on tree visualization or that perform specific analyses on them. However, such applications are rarely suitable for large-scale surveys, in which a higher level of automation is required. Currently, many genome-wide analyses rely on tree-like data representation and hence there is a growing need for scalable tools to handle tree structures at large scale. Results Here we present the Environment for Tree Exploration (ETE), a python programming toolkit that assists in the automated manipulation, analysis and visualization of hierarchical trees. ETE libraries provide a broad set of tree handling options as well as specific methods to analyze phylogenetic and clustering trees. Among other features, ETE allows for the independent analysis of tree partitions, has support for the extended newick format, provides an integrated node annotation system and permits to link trees to external data such as multiple sequence alignments or numerical arrays. In addition, ETE implements a number of built-in analytical tools, including phylogeny-based orthology prediction and cluster validation techniques. Finally, ETE's programmable tree drawing engine can be used to automate the graphical rendering of trees with customized node-specific visualizations. Conclusions ETE provides a complete set of methods to manipulate tree data structures that extends current functionality in other bioinformatic toolkits of a more general purpose. ETE is free software and can be downloaded from http://ete.cgenomics.org. PMID:20070885

More than just records: analysing natural history collections for biodiversity planning.

PubMed

Ward, Darren F

2012-01-01

Natural History Collections (NHCs) play a central role as sources of data for biodiversity and conservation. Yet, few NHCs have examined whether the data they contain is adequately representative of local biodiversity. I examined over 15,000 databased records of Hymenoptera from 1435 locations across New Zealand collected over the past 90 years. These records are assessed in terms of their geographical, temporal, and environmental coverage across New Zealand. Results showed that the spatial coverage of records was significantly biased, with the top four areas contributing over 51% of all records. Temporal biases were also evident, with a large proportion (40%) of records collected within a short time period. The lack of repeat visits to specific locations indicated that the current set of NHC records would be of limited use for long-term ecological research. Consequently, analyses and interpretation of historical data, for example, shifts in community composition, would be limited. However, in general, NHC records provided good coverage of the diversity of New Zealand habitats and climatic environments, although fewer NHC records were represented at cooler temperatures (<5°C) and the highest rainfalls (>5000 mm/yr). Analyses of NHCs can be greatly enhanced by using simple techniques that examine collection records in terms of environmental and geographical space. NHCs that initiate a systematic sampling strategy will provide higher quality data for biodiversity research than ad hoc or point samples, as is currently the norm. Although NHCs provide a rich source of information they could be far better utilised in a range of large-scale ecological and conservation studies.

More Than Just Records: Analysing Natural History Collections for Biodiversity Planning

PubMed Central

Ward, Darren F.

2012-01-01

Natural History Collections (NHCs) play a central role as sources of data for biodiversity and conservation. Yet, few NHCs have examined whether the data they contain is adequately representative of local biodiversity. I examined over 15,000 databased records of Hymenoptera from 1435 locations across New Zealand collected over the past 90 years. These records are assessed in terms of their geographical, temporal, and environmental coverage across New Zealand. Results showed that the spatial coverage of records was significantly biased, with the top four areas contributing over 51% of all records. Temporal biases were also evident, with a large proportion (40%) of records collected within a short time period. The lack of repeat visits to specific locations indicated that the current set of NHC records would be of limited use for long-term ecological research. Consequently, analyses and interpretation of historical data, for example, shifts in community composition, would be limited. However, in general, NHC records provided good coverage of the diversity of New Zealand habitats and climatic environments, although fewer NHC records were represented at cooler temperatures (<5°C) and the highest rainfalls (>5000 mm/yr). Analyses of NHCs can be greatly enhanced by using simple techniques that examine collection records in terms of environmental and geographical space. NHCs that initiate a systematic sampling strategy will provide higher quality data for biodiversity research than ad hoc or point samples, as is currently the norm. Although NHCs provide a rich source of information they could be far better utilised in a range of large-scale ecological and conservation studies. PMID:23185605

Importance of contraction history on muscle force of porcine urinary bladder smooth muscle.

PubMed

Menzel, Robin; Böl, Markus; Siebert, Tobias

2017-02-01

The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturition, the circumference of the urinary bladder changes enormously. Thus, FD might be an important phenomenon during smooth muscle contraction. Electrically stimulated, intact urinary bladder strips from pigs (n = 10) were suspended in an aerated-filled organ bath, and different isometric, isotonic, and isokinetic contraction protocols were performed to determine the force-length and the force-velocity relation. FD and FE were assessed in concentric and eccentric contractions with different ramp lengths and ramp velocities. Bladder smooth muscles exhibit considerable amounts of FD and FE. The amount of FD increased significantly with ramp length, while FE did not change. However, FE and FD were independent of ramp velocity. The results imply that smooth muscle bladder strips exhibit similar muscle properties and history-dependent behaviour compared to striated muscles. The provided dataset of muscle properties is important for bladder modelling as well as for the analyses and interpretation of dynamic bladder filling and voiding.

CytoCom: a Cytoscape app to visualize, query and analyse disease comorbidity networks.

PubMed

Moni, Mohammad Ali; Xu, Haoming; Liò, Pietro

2015-03-15

CytoCom is an interactive plugin for Cytoscape that can be used to search, explore, analyse and visualize human disease comorbidity network. It represents disease-disease associations in terms of bipartite graphs and provides International Classification of Diseases, Ninth Revision (ICD9)-centric and disease name centric views of disease information. It allows users to find associations between diseases based on the two measures: Relative Risk (RR) and [Formula: see text]-correlation values. In the disease network, the size of each node is based on the prevalence of that disease. CytoCom is capable of clustering disease network based on the ICD9 disease category. It provides user-friendly access that facilitates exploration of human diseases, and finds additional associated diseases by double-clicking a node in the existing network. Additional comorbid diseases are then connected to the existing network. It is able to assist users for interpretation and exploration of the human diseases by a variety of built-in functions. Moreover, CytoCom permits multi-colouring of disease nodes according to standard disease classification for expedient visualization. © The Author 2014. Published by Oxford University Press.

AHRQ series on complex intervention systematic reviews-paper 6: PRISMA-CI extension statement and checklist.

PubMed

Guise, Jeanne-Marie; Butler, Mary E; Chang, Christine; Viswanathan, Meera; Pigott, Terri; Tugwell, Peter

2017-10-01

Complex interventions are widely used in health systems, public health, education, and communities and are increasingly the subject of systematic reviews. Oversimplification and inconsistencies in reporting about complex interventions can limit the usability of review findings. Although guidance exists to ensure that reports of individual studies and systematic reviews adhere to accepted scientific standards, their design-specific focus leaves important reporting gaps relative to complex interventions in health care. This paper provides a stand-alone extension to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting tool for complex interventions-PRISMA-CI-to help authors, publishers, and readers understand and apply to systematic reviews of complex interventions. PRISMA-CI development followed the Enhancing the QUAlity and Transparency Of health Research Network guidance for extensions and focused on adding or modifying only essential items that are truly unique to complex interventions and are not covered by broader interpretation of current PRISMA guidance. PRISMA-CI provides an important structure and guidance for systematic reviews and meta-analyses for the highly prevalent and dynamic field of complex interventions. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Hydroclimatological data and analyses from a headwaters region of Mongolia as boundary objects in interdisciplinary climate change research

NASA Astrophysics Data System (ADS)

Venable, N. B. H.

2017-09-01

Collaborative work on increasingly complex hydroclimatic investigations often crosses disciplinary boundaries. Elements of scientific inquiry, such as data or the results of analyses can become objectified, or capable of being adopted and/or adapted by users from multiple disciplinary realms. These objects often provide a bridge for collaborative endeavors, or are used as tools by individuals pursuing multi-disciplinary work. Boundary object terminology was first formalized and applied by social scientists. However, few examples of the application of this useful framework are found in the hydrologic literature. The construct is applied here to identify and discuss how common research products and processes are used both internally and externally through providing examples from a project examining the historical and paleo proxy-based hydroclimatology of a headwaters region of Mongolia. The boundary object concept is valuable to consider when conducting and critiquing basic research, collaborating across multiple disciplinary teams as when studying climate change issues, as an individual researcher working in a cross boundary sense using methods from differing disciplines to answer questions, and/or when one group adapts the work of another to their own research problems or interpretive needs, as occurred with selected products of this project.

Basic data from five core holes in the Raft River geothermal area, Cassia County, Idaho

USGS Publications Warehouse

Crosthwaite, E. G.

1976-01-01

meters) were completed in the area (Crosthwaite, 1974), and the Aerojet Nuclear Company, under the auspices of the U.S. Energy Research and Development Administration, was planning some deep drilling 4,000 to 6,000 feet (1,200 to 1,800 meters) (fig. 1). The purpose of the core drilling was to provide information to test geophysical interpretations of the subsurface structure and lithology and to provide hydrologic and geologic data on the shallow part of the geothermal system. Samples of the core were made available to several divisions and branches of the Geological Survey and to people and agencies outside the Survey. This report presents the basic data from the core holes that had been collected to September 1, 1975, and includes lithologic and geophysical well logs, chemical analyses of water (table 1), and laboratory analyses of cores (table 2) that were completed as of the above date. The data were collected by the Idaho District office, Hydrologic Laboratory, Borehole Geophysics Research Project, and Drilling, Sampling, and Testing Section, all of the Water Resources Division, and the Branch of Central Environmental Geology of the Geologic Divison.

Heart rate and sentiment experimental data with common timeline.

PubMed

Salamon, Jaromír; Mouček, Roman

2017-12-01

Sentiment extraction and analysis using spoken utterances or written corpora as well as collection and analysis of human heart rate data using sensors are commonly used techniques and methods. On the other hand, these have been not combined yet. The collected data can be used e.g. to investigate the mutual dependence of human physical and emotional activity. The paper describes the procedure of parallel acquisition of heart rate sensor data and tweets expressing sentiment and difficulties related to this procedure. The obtained datasets are described in detail and further discussed to provide as much information as possible for subsequent analyses and conclusions. Analyses and conclusions are not included in this paper. The presented experiment and provided datasets serve as the first basis for further studies where all four presented data sources can be used independently, combined in a reasonable way or used all together. For instance, when the data is used all together, performing studies comparing human sensor data, acquired noninvasively from the surface of the human body and considered as more objective, and human written data expressing the sentiment, which is at least partly cognitively interpreted and thus considered as more subjective, could be beneficial.

Just Do It: Resources for Interpretive Planning

ERIC Educational Resources Information Center

Koepler, Jes

2008-01-01

Now that you have finished reading this journal issue and understand what interpretive planning is and when to apply it, how can you get started and just "do" it? This article provides an annotated list of practical handbooks and internet resources that provide guidelines for museum practitioners to engage in interpretive planning at institutions…

Environmental change at the southern Cape coast of South Africa as inferred from a high-resolution Holocene sediment record from Eilandvlei

NASA Astrophysics Data System (ADS)

Wündsch, Michael; Haberzettl, Torsten; Meadows, Michael E.; Kirsten, Kelly L.; Meschner, Stephanie; Frenzel, Peter; Baade, Jussi; Daut, Gerhard; Mäusbacher, Roland; Kasper, Thomas; Quick, Lynne J.; Cawthra, Hayley C.; Zabel, Matthias

2016-04-01

The RAIN project (Regional Archives for Integrated iNvestigations), funded by the German Federal Ministry of Education and Research (BMBF), focuses on closely integrated investigations of terrestrial and marine geoarchives from southern Africa in order to assess environmental changes during the late Quaternary. For this purpose, various marine and terrestrial sediment records from the three major rainfall zones of South Africa (winter-, summer- and year-round rainfall zone) were recovered and analysed applying a wide range of methods (e.g., sedimentology, seismic stratigraphy, geochronology, organic and inorganic geochemistry, mineralogy, stable isotopes, micropalaeontology, palynology). In this contribution, we present results and interpretations obtained from a 30.5 m sediment core retrieved from the coastal lake Eilandvlei located within the year-round rainfall zone. Geochemical investigations (Ca, Sr, total inorganic carbon) indicate major changes in the sediment carbonate contents which were linked to variations in the marine influence received at the site throughout the covered period. The interpretation of carbonates reflecting a varying marine influence is corroborated by micropalaeontological analyses (viz. ostracod and diatom assemblages) which reveal strong similarities with the geochemical data. In order to establish a reliable radiocarbon (14C) chronology for this record, it is of particular importance to consider the impact of 14C-depleted ("old") marine carbon contained in the measured samples causing reservoir effects. Therefore, two marine molluscan shells collected alive before AD 1950 ("pre-bomb") were analysed to determine the regional marine reservoir offset (ΔR). The obtained ΔR values of 134 ± 38 and 161 ± 38 14C yrs represent the first data available for the south coast of South Africa. However, the application of the resulting average ΔR = 148 ± 54 14C yrs for the calibration of the entire Eilandvlei record underestimates the reservoir effects for the older deposits. This indicates a temporal variability on the degree of old marine carbon affecting Eilandvlei during the Holocene, which was possibly caused by changes in the connectivity between the lake system and the ocean as well as changes in the extent of upwelling along the coast. To solve this problem, variable past reservoir effects were determined based on the dating of sample pairs which were assumingly deposited contemporaneously and are composed of different source material (marine/terrestrial). This approach provides the most reliable chronology revealing a median basal age of 8880 +145/220 cal BP. Thus, the Eilandvlei core represents an ultra-high-resolution record of environmental change during the Holocene, which is a unique discovery for entire southern Africa. Palaeoenvironmental interpretations of the this record strongly suggest that sedimentation conditions at Eilandvlei were closely coupled to global sea level changes. Moreover, the multi-proxy approach provides great potential for palaeoclimatic interpretations of this record. For example, geochemical proxies reflecting the varying input of terrestrial material suggest changes in the discharge of inflowing rivers which, in turn, may be linked to variations in rainfall and hence climate within the year-round rainfall zone of South Africa.

Bayesian Estimation of Small Effects in Exercise and Sports Science.

PubMed

Mengersen, Kerrie L; Drovandi, Christopher C; Robert, Christian P; Pyne, David B; Gore, Christopher J

2016-01-01

The aim of this paper is to provide a Bayesian formulation of the so-called magnitude-based inference approach to quantifying and interpreting effects, and in a case study example provide accurate probabilistic statements that correspond to the intended magnitude-based inferences. The model is described in the context of a published small-scale athlete study which employed a magnitude-based inference approach to compare the effect of two altitude training regimens (live high-train low (LHTL), and intermittent hypoxic exposure (IHE)) on running performance and blood measurements of elite triathletes. The posterior distributions, and corresponding point and interval estimates, for the parameters and associated effects and comparisons of interest, were estimated using Markov chain Monte Carlo simulations. The Bayesian analysis was shown to provide more direct probabilistic comparisons of treatments and able to identify small effects of interest. The approach avoided asymptotic assumptions and overcame issues such as multiple testing. Bayesian analysis of unscaled effects showed a probability of 0.96 that LHTL yields a substantially greater increase in hemoglobin mass than IHE, a 0.93 probability of a substantially greater improvement in running economy and a greater than 0.96 probability that both IHE and LHTL yield a substantially greater improvement in maximum blood lactate concentration compared to a Placebo. The conclusions are consistent with those obtained using a 'magnitude-based inference' approach that has been promoted in the field. The paper demonstrates that a fully Bayesian analysis is a simple and effective way of analysing small effects, providing a rich set of results that are straightforward to interpret in terms of probabilistic statements.

Thinker, Soldier, Scribe: cross-sectional study of researchers' roles and author order in the Annals of Internal Medicine

PubMed Central

Perneger, Thomas V; Poncet, Antoine; Carpentier, Marc; Agoritsas, Thomas; Combescure, Christophe; Gayet-Ageron, Angèle

2017-01-01

Objective How researchers’ contributions relate to author order on the byline remains unclear. We sought to identify researchers’ contributions associated with author order, and to explore the existence of author profiles. Design Observational study. Setting Published record. Participants 1139 authors of 119 research articles published in 2015 in the Annals of Internal Medicine. Primary outcomes Presence or absence of 10 contributions, reported by each author, published in the journal. Results On average, first authors reported 7.1 contributions, second authors 5.2, middle authors 4.0, penultimate authors 4.5 and last authors 6.4 (p<0.001). The first author made the greatest contributions to drafting the article, designing the study, analysing and interpreting the data, and providing study materials or patients. The second author contributed to data analysis as well and to drafting the article. The last author was most involved in obtaining the funding, critically revising the article, designing the study and providing support. Factor analysis yielded three author profiles—Thinker (study design, revision of article, obtaining funding), Soldier (providing material or patients, providing administrative and logistical support, collecting data) and Scribe (analysis and interpretation of data, drafting the article, statistical expertise). These profiles do not strictly correspond to byline position. Conclusions First, second and last authors of research articles made distinct contributions to published research. Three authorship profiles can be used to summarise author contributions. These findings shed light on the organisation of clinical research teams and may help researchers discuss, plan and report authorship in a more transparent way. PMID:28647720

Tools to Support Interpreting Multiple Regression in the Face of Multicollinearity

PubMed Central

Kraha, Amanda; Turner, Heather; Nimon, Kim; Zientek, Linda Reichwein; Henson, Robin K.

2012-01-01

While multicollinearity may increase the difficulty of interpreting multiple regression (MR) results, it should not cause undue problems for the knowledgeable researcher. In the current paper, we argue that rather than using one technique to investigate regression results, researchers should consider multiple indices to understand the contributions that predictors make not only to a regression model, but to each other as well. Some of the techniques to interpret MR effects include, but are not limited to, correlation coefficients, beta weights, structure coefficients, all possible subsets regression, commonality coefficients, dominance weights, and relative importance weights. This article will review a set of techniques to interpret MR effects, identify the elements of the data on which the methods focus, and identify statistical software to support such analyses. PMID:22457655

Tools to support interpreting multiple regression in the face of multicollinearity.

PubMed

Kraha, Amanda; Turner, Heather; Nimon, Kim; Zientek, Linda Reichwein; Henson, Robin K

2012-01-01

While multicollinearity may increase the difficulty of interpreting multiple regression (MR) results, it should not cause undue problems for the knowledgeable researcher. In the current paper, we argue that rather than using one technique to investigate regression results, researchers should consider multiple indices to understand the contributions that predictors make not only to a regression model, but to each other as well. Some of the techniques to interpret MR effects include, but are not limited to, correlation coefficients, beta weights, structure coefficients, all possible subsets regression, commonality coefficients, dominance weights, and relative importance weights. This article will review a set of techniques to interpret MR effects, identify the elements of the data on which the methods focus, and identify statistical software to support such analyses.

12 CFR Appendix D to Part 230 - Issuance of Staff Interpretations

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Issuance of Staff Interpretations D Appendix D...—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff interpretations of this part. These interpretations provide the...

12 CFR Appendix D to Part 230 - Issuance of Staff Interpretations

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Issuance of Staff Interpretations D Appendix D...—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff interpretations of this part. These interpretations provide the...

12 CFR Appendix D to Part 230 - Issuance of Staff Interpretations

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Issuance of Staff Interpretations D Appendix D...—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff interpretations of this part. These interpretations provide the...

Development of Cognitive Bias Modification (CBM) Tools to Promote Adjustment During Reintegration Following Deployment

DTIC Science & Technology

2015-11-01

addressed in Study 1, was to measure the associations between state and trait anger and biases in anger-related attention and interpretation. This aim was...presented in the recent MOMRP conference, and physiological SCR data are in the last stages of analyses. 15. SUBJECT TERMS anger, aggression, attention ...threat conditions, ranging from safety to acute danger, considerable plasticity in threat-related attention and threat interpretation is required

Quality of core collections for effective utilisation of genetic resources review, discussion and interpretation.

PubMed

Odong, T L; Jansen, J; van Eeuwijk, F A; van Hintum, T J L

2013-02-01

Definition of clear criteria for evaluation of the quality of core collections is a prerequisite for selecting high-quality cores. However, a critical examination of the different methods used in literature, for evaluating the quality of core collections, shows that there are no clear guidelines on the choices of quality evaluation criteria and as a result, inappropriate analyses are sometimes made leading to false conclusions being drawn regarding the quality of core collections and the methods to select such core collections. The choice of criteria for evaluating core collections appears to be based mainly on the fact that those criteria have been used in earlier publications rather than on the actual objectives of the core collection. In this study, we provide insight into different criteria used for evaluating core collections. We also discussed different types of core collections and related each type of core collection to their respective evaluation criteria. Two new criteria based on genetic distance are introduced. The consequences of the different evaluation criteria are illustrated using simulated and experimental data. We strongly recommend the use of the distance-based criteria since they not only allow the simultaneous evaluation of all variables describing the accessions, but they also provide intuitive and interpretable criteria, as compared with the univariate criteria generally used for the evaluation of core collections. Our findings will provide genebank curators and researchers with possibilities to make informed choices when creating, comparing and using core collections.

On observation of local strong heterogeneity in the Earth's inner core below southeastern Asia

NASA Astrophysics Data System (ADS)

Krasnoshchekov, D. N.; Kaazik, P. B.; Ovtchinnikov, V. M.

2016-12-01

The dimensions and nature of multi-scale structural heterogeneities in the Earth's inner core (IC) provide important constraints on its mineralogy and formation history. Teleseismic body waves with turn points close to the inner core boundary (ICB) provide a unique tool for imaging the fine structure of the upper IC. In this study, we invoke differential travel times and amplitudes of PKPBC and PKPDF waveforms observed in crossing polar and equatorial paths to provide more constraints on the heterogeneity previously located in the quasi-eastern hemisphere of the IC (Kaazik et al., 2015; Krasnoshchekov et al., 2016). A more refined analysis of quasi-polar PKPBC/PKPDF amplitude ratios measured within the heterogeneity indicates that seismic attenuation is both frequency and depth dependent, and its relatively low Q-factor at 1 Hz of approximately 118 tends to grow with depth. Outside the heterogeneity, no pronounced polar-equatorial differences are observed; the estimated Q factor is about twice as large and not directionally dependent. We also analyse new differential travel times of rays that enable sampling of the anomaly at greater depths. The analysis exhibits the polar - equatorial contrasts observed in the heterogeneity terminate at approximately 520 km below the ICB, which we interpret to be its bottom. The earlier interpretation of the heterogeneity in terms of strong anisotropic volume amidst the almost isotropic eastern hemisphere of the IC can be retained, and the lower bound of anisotropy strength within the anomaly is determined to be 2%.

Monitoring population status of sea otters (Enhydra lutris) in Glacier Bay National Park and Preserve, Alaska: options and considerations

USGS Publications Warehouse

Esslinger, George G.; Esler, Daniel N.; Howlin, S.; Starcevich, L.A.

2015-06-25

After many decades of absence from southeast Alaska, sea otters (Enhydra lutris) are recolonizing parts of their former range, including Glacier Bay, Alaska. Sea otters are well known for structuring nearshore ecosystems and causing community-level changes such as increases in kelp abundance and changes in the size and number of other consumers. Monitoring population status of sea otters in Glacier Bay will help park researchers and managers understand and interpret sea otter-induced ecosystem changes relative to other sources of variation, including potential human-induced impacts such as ocean acidification, vessel disturbance, and oil spills. This report was prepared for the National Park Service (NPS), Southeast Alaska Inventory and Monitoring Network following a request for evaluation of options for monitoring sea otter population status in Glacier Bay National Park and Preserve. To meet this request, we provide a detailed consideration of the primary method of assessment of abundance and distribution, aerial surveys, including analyses of power to detect interannual trends and designs to reduce variation around annual abundance estimates. We also describe two alternate techniques for evaluating sea otter population status—(1) quantifying sea otter diets and energy intake rates, and (2) detecting change in ages at death. In addition, we provide a brief section on directed research to identify studies that would further our understanding of sea otter population dynamics and effects on the Glacier Bay ecosystem, and provide context for interpreting results of monitoring activities.

Attitudes to and implementation of video interpretation in a Danish hospital: A cross-sectional study.

PubMed

Mottelson, Ida Nygaard; Sodemann, Morten; Nielsen, Dorthe Susanne

2018-03-01

Immigrants, refugees, and their descendants comprise 12% of Denmark's population. Some of these people do not speak or understand Danish well enough to communicate with the staff in a healthcare setting and therefore need interpreter services. Interpretation through video conferencing equipment (video interpretation) is frequently used and creates a forum where the interpreter is not physically present in the medical consultation. The aim of this study was to investigate the attitudes to and experiences with video interpretation among charge nurses in a Danish university hospital. An electronic questionnaire was sent to 99 charge nurses. The questionnaire comprised both closed and open-ended questions. The answers were analysed using descriptive statistics and thematic text condensation. Of the 99 charge nurses, 78 (79%) completed the questionnaire. Most charge nurses, 21 (91%) of the daily/monthly users, and 21 (72%) of the monthly/yearly users, said that video interpretation increased the quality of their conversations with patients. A total of 19 (24%) departments had not used video interpretation within the last 12 months. The more the charge nurses used video interpretation, the more satisfied they were. Most of the charge nurses using video interpretation expressed satisfaction with the technology and found it easy to use. Some charge nurses are still content to allow family or friends to interpret. To reach its full potential, video interpretation technology has to be reliable and easily accessible for any consultation, including at the bedside.

Perception of mental health in Pakistani nomads: An interpretative phenomenological analyses

PubMed Central

Choudhry, Fahad Riaz; Bokharey, Iram Zehra

2013-01-01

The study was conducted to explore the mental health issues of Pakistani nomads and to uncover their concept, ideation, and perception about mental health and illnesses. It was an exploratory study situated in the qualitative paradigm. The research strategy used was Interpretative Phenomenological Analysis (IPA), as the study was planned to explore the lived experiences of nomads regarding mental health and coping strategies and how they interpret those experiences. For data collection, focus group discussions (FGDs) were conducted. Seven participants were included in the FGDs, and two FGDs were conducted composed of both genders. The responses were recorded, and data were transcribed and analysed using IPA. Data verification procedures of peer review, which help to clarify researcher bias and rich thick description, were used. The major themes were lack of resources and myriad unfulfilled needs, specifically the basic needs (food, shelter, and drinking and bathing water). Moreover, a strong desire to fulfil the secondary needs of enjoyment and having luxuries was also reflected. A list of recommendations was forwarded for policy making of this marginalized community and to create awareness regarding mental health. PMID:24369779

Perception of mental health in Pakistani nomads: an interpretative phenomenological analyses.

PubMed

Choudhry, Fahad Riaz; Bokharey, Iram Zehra

2013-12-19

The study was conducted to explore the mental health issues of Pakistani nomads and to uncover their concept, ideation, and perception about mental health and illnesses. It was an exploratory study situated in the qualitative paradigm. The research strategy used was Interpretative Phenomenological Analysis (IPA), as the study was planned to explore the lived experiences of nomads regarding mental health and coping strategies and how they interpret those experiences. For data collection, focus group discussions (FGDs) were conducted. Seven participants were included in the FGDs, and two FGDs were conducted composed of both genders. The responses were recorded, and data were transcribed and analysed using IPA. Data verification procedures of peer review, which help to clarify researcher bias and rich thick description, were used. The major themes were lack of resources and myriad unfulfilled needs, specifically the basic needs (food, shelter, and drinking and bathing water). Moreover, a strong desire to fulfil the secondary needs of enjoyment and having luxuries was also reflected. A list of recommendations was forwarded for policy making of this marginalized community and to create awareness regarding mental health.

Hawaiian temples and their orientations: issues of method and interpretation

NASA Astrophysics Data System (ADS)

Ruggles, Clive L. N.

2015-08-01

In 2002 I began a collaboration with Pat Kirch (Berkeley) to survey the temple sites (heiau) in the Kahikinui and Kaupo districts of southern Maui, and study their orientations and potential astronomical significance. Our investigations of over 70 temples in the area were completed in 2011 and are due for publication in 2016. Pat Kirch will present some of our main conclusions in his keynote talk within FM2. In this paper I propose to concentrate on issues of field methodology and procedure that have wider implications for developments in method and practice within archaeoastronomy. Methodologically, temple sites in the Hawaiian Islands constitute a "halfway house" between prehistoric monuments in Europe, where the only evidence is archaeological and studies of orientations tend to follow formal, "data-driven" or statistical, approaches, and Mesoamerica, where the existence of pre-conquest written records and inscriptions and post-conquest ethnohistory relegate "alignment studies" to a secondary role. In Hawai‘i, cultural data, including oral histories recorded after conquest, provide a finer balance between historical accounts and the physical evidence. Selection issues at the Maui temple sites include distinguishing marginal temple sites from house sites and identifying the intended direction of orientation at complex structures. Initial analyses of the principal orientations identified clusterings in orientation which were interpreted as relating to different gods, and particular the war-god Ku and the god of dryland agriculture, Lono. Later, more comprehensive surveys revealed evidence of observing platforms and foresights at some of the Lono temples, suggesting that systematic observations were made of the Pleiades, known from the ethnohistory to be of particular calendrical significance. This type of alignment evidence is too subjective to be sustained on the basis of a formal analysis alone but, given the historical context, provides a more robust cultural interpretation.

Exploratory Visual Analysis of Statistical Results from Microarray Experiments Comparing High and Low Grade Glioma

PubMed Central

Reif, David M.; Israel, Mark A.; Moore, Jason H.

2007-01-01

The biological interpretation of gene expression microarray results is a daunting challenge. For complex diseases such as cancer, wherein the body of published research is extensive, the incorporation of expert knowledge provides a useful analytical framework. We have previously developed the Exploratory Visual Analysis (EVA) software for exploring data analysis results in the context of annotation information about each gene, as well as biologically relevant groups of genes. We present EVA as a flexible combination of statistics and biological annotation that provides a straightforward visual interface for the interpretation of microarray analyses of gene expression in the most commonly occuring class of brain tumors, glioma. We demonstrate the utility of EVA for the biological interpretation of statistical results by analyzing publicly available gene expression profiles of two important glial tumors. The results of a statistical comparison between 21 malignant, high-grade glioblastoma multiforme (GBM) tumors and 19 indolent, low-grade pilocytic astrocytomas were analyzed using EVA. By using EVA to examine the results of a relatively simple statistical analysis, we were able to identify tumor class-specific gene expression patterns having both statistical and biological significance. Our interactive analysis highlighted the potential importance of genes involved in cell cycle progression, proliferation, signaling, adhesion, migration, motility, and structure, as well as candidate gene loci on a region of Chromosome 7 that has been implicated in glioma. Because EVA does not require statistical or computational expertise and has the flexibility to accommodate any type of statistical analysis, we anticipate EVA will prove a useful addition to the repertoire of computational methods used for microarray data analysis. EVA is available at no charge to academic users and can be found at http://www.epistasis.org. PMID:19390666

An Improved Method for Interpretation of Concentration-Discharge Relationships in Riverine Water-Quality Data

NASA Astrophysics Data System (ADS)

Zhang, Q.; Harman, C. J.; Ball, W. P.

2016-12-01

Riverine concentration-discharge (C-Q) relationships are powerful indicators that can provide important clues toward understanding nutrient and sediment export dynamics from river systems, and the analysis of such relations has been a long-standing topic of importance in hydrologic literature. Proper interpretation of such relationships can be made complex, however, if the relationships of ln(C) ln(Q) are nonlinear or if the relationships change over time, season, or discharge. Methods of addressing these issues by "binning" data or smoothing trends can introduce artifacts and ambiguities that obscure underlying interactions among time, discharge, and season. Here we illustrate these issues with examples and propose an alternative method that uses the regression coefficients of the recently-developed WRTDS ("Weighted Regressions on Time, Discharge, and Season") model for examining riverine C-Q relationships, including their uncertainty. The method is applied to sediment concentration data from Susquehanna River at Conowingo Dam (Maryland, USA) to illustrate how the WRTDS coefficients can be accessed and presented in ways that provide additional insights toward the interpretation of river water-quality data. For this case, the results clearly reveal that sediment concentration in the reservoir effluent has become more sensitive to discharge at moderate and high flows (but not very low flows) as it approaches sediment storage capacity, reaffirming the recently-documented decadal-scale decline in reservoir trapping performance. The study also highlights an additional benefit of the method, which is the ability to perform uncertainty analyses. The proposed approach can be implemented by running additional R codes within the WRTDS software - such codes are made available to users through a DOI-referenced archive site (http://dx.doi.org/10.7281/T18G8HM0) that will be maintained for at least five years after publication.

Using HEC-RAS to Enhance Interpretive Capabilities of Geomorphic Assessments

NASA Astrophysics Data System (ADS)

Keefer, L. L.

2005-12-01

The purpose of a geomorphic assessment is to characterize and evaluate a fluvial system for determining the past watershed and channel conditions, current geomorphic character and potential future channel adjustments. The geomorphic assessment approach utilized by the Illinois State Water Survey assesses channel response to disturbance at multiple temporal and spatial scales to help identify the underlying factors and events which led to the existing channel morphology. This is accomplished through two phases of investigation that involve a historical and physical analysis of the watershed, disturbance history, and field work at increasing levels of detail. To infer future channel adjustments, the geomorphic assessment protocol combines two methods of analyses that are dependent on the quantity and detail of the available data. The first method is the compilation of multiple lines of evidence using qualitative information related to the dominant fluvial environment, channel gradient, stream power thresholds, and channel evolution models. The second method is the use of hydraulic models which provide additional interpretative skills to evaluate potential channel adjustments. The structured data collection framework of the geomorphic assessment approach is used for the development of a HEC-RAS model. The model results are then used as another tool to determine the influence of bridges and control structures on channel stability, stream power profiles to identify potential channel bed degradation zones, and provide data for physically-based bank stability models. This poster will demonstrate the advantages of using a hydraulic model, such as HEC-RAS, to expand the interpretive capabilities of geomorphic assessments. The results from applying this approach will be demonstrated for the Big Creek watershed of the Cache River Basin in southern Illinois.

Post-examination interpretation of objective test data: monitoring and improving the quality of high-stakes examinations--a commentary on two AMEE Guides.

PubMed

Tavakol, Mohsen; Dennick, Reg

2012-01-01

As great emphasis is rightly placed upon the importance of assessment to judge the quality of our future healthcare professionals, it is appropriate not only to choose the most appropriate assessment method, but to continually monitor the quality of the tests themselves, in a hope that we may continually improve the process. This article stresses the importance of quality control mechanisms in the exam cycle and briefly outlines some of the key psychometric concepts including reliability measures, factor analysis, generalisability theory and item response theory. The importance of such analyses for the standard setting procedures is emphasised. This article also accompanies two new AMEE Guides in Medical Education (Tavakol M, Dennick R. Post-examination Analysis of Objective Tests: AMEE Guide No. 54 and Tavakol M, Dennick R. 2012. Post examination analysis of objective test data: Monitoring and improving the quality of high stakes examinations: AMEE Guide No. 66) which provide the reader with practical examples of analysis and interpretation, in order to help develop valid and reliable tests.

Cost-Effectiveness Models in Age-Related Macular Degeneration: Issues and Challenges.

PubMed

Schmier, Jordana K; Hulme-Lowe, Carolyn K

2016-03-01

Age-related macular degeneration (AMD) is a common ophthalmic condition that can have few symptoms in its early stage but can progress to major visual impairment. While there are no treatments for early-stage AMD, there are multiple modalities of treatment for advanced disease. Given the increasing prevalence of the disease, there are dozens of analyses of cost effectiveness of AMD treatments, but methods and approaches vary broadly. The goal of this review was to identify, characterize, and critique published models in AMD and provide guidance for their interpretation. After a literature review was performed to identify studies, and exclusion criteria applied to limit the review to studies comparing treatments for AMD, we compared methods across the 36 studies meeting the review criteria. To some extent, variation was related to targeting different audiences or acknowledging the most appropriate population for a given treatment. However, the review identified potential areas of uncertainty and difficulty in interpretation, particularly regarding duration of observation periods and the importance of visual acuity as an endpoint or a proxy for patient-reported utilities. We urge thoughtful consideration of these study characteristics when comparing results.

Short-wave infrared reflectance investigation of sites of paleobiological interest: applications for Mars exploration.

PubMed

Brown, Adrian; Walter, Malcolm; Cudahy, Thomas

2004-01-01

Rover missions to the rocky bodies of the Solar System and especially to Mars require lightweight, portable instruments that use minimal power, require no sample preparation, and provide suitably diagnostic mineralogical information to an Earth-based exploration team. Short-wave infrared (SWIR) spectroscopic instruments such as the Portable Infrared Mineral Analyser (PIMA, Integrated Spectronics Pty Ltd., Baulkham Hills, NSW, Australia) fulfill all these requirements. We describe an investigation of a possible Mars analogue site using a PIMA instrument. A survey was carried out on the Strelley Pool Chert, an outcrop of stromatolitic, silicified Archean carbonate and clastic succession in the Pilbara Craton, interpreted as being modified by hydrothermal processes. The results of this study demonstrate the capability of SWIR techniques to add significantly to the geological interpretation of such hydrothermally altered outcrops. Minerals identified include dolomite, white micas such as illite-muscovite, and chlorite. In addition, the detection of pyrophyllite in a bleached and altered unit directly beneath the succession suggests acidic, sulfur-rich hydrothermal activity may have interacted with the silicified sediments of the Strelley Pool Chert.

Disclosing discourses: biomedical and hospitality discourses in patient education materials.

PubMed

Öresland, Stina; Friberg, Febe; Määttä, Sylvia; Öhlen, Joakim

2015-09-01

Patient education materials have the potential to strengthen the health literacy of patients. Previous studies indicate that readability and suitability may be improved. The aim of this study was to explore and analyze discourses inherent in patient education materials since analysis of discourses could illuminate values and norms inherent in them. Clinics in Sweden that provided colorectal cancer surgery allowed access to written information and 'welcome letters' sent to patients. The material was analysed by means of discourse analysis, embedded in Derrida's approach of deconstruction. The analysis revealed a biomedical discourse and a hospitality discourse. In the biomedical discourse, the subject position of the personnel was interpreted as the messenger of medical information while that of the patients as the carrier of diagnoses and recipients of biomedical information. In the hospitality discourse, the subject position of the personnel was interpreted as hosts who invite and welcome the patients as guests. The study highlights the need to eliminate paternalism and fosters a critical reflective stance among professionals regarding power and paternalism inherent in health care communication. © 2015 John Wiley & Sons Ltd.

What is preexisting strength? Predicting free association probabilities, similarity ratings, and cued recall probabilities.

PubMed

Nelson, Douglas L; Dyrdal, Gunvor M; Goodmon, Leilani B

2005-08-01

Measuring lexical knowledge poses a challenge to the study of the influence of preexisting knowledge on the retrieval of new memories. Many tasks focus on word pairs, but words are embedded in associative networks, so how should preexisting pair strength be measured? It has been measured by free association, similarity ratings, and co-occurrence statistics. Researchers interpret free association response probabilities as unbiased estimates of forward cue-to-target strength. In Study 1, analyses of large free association and extralist cued recall databases indicate that this interpretation is incorrect. Competitor and backward strengths bias free association probabilities, and as with other recall tasks, preexisting strength is described by a ratio rule. In Study 2, associative similarity ratings are predicted by forward and backward, but not by competitor, strength. Preexisting strength is not a unitary construct, because its measurement varies with method. Furthermore, free association probabilities predict extralist cued recall better than do ratings and co-occurrence statistics. The measure that most closely matches the criterion task may provide the best estimate of the identity of preexisting strength.

Evaluating clinically meaningful change on the ITP-PAQ: preliminary estimates of minimal important differences.

PubMed

Mathias, Susan D; Gao, Sue K; Rutstein, Mark; Snyder, Claire F; Wu, Albert W; Cella, David

2009-02-01

Interpretation of data from health-related quality of life (HRQoL) questionnaires can be enhanced with the availability of minimally important difference (MID) estimates. This information will aid clinicians in interpreting HRQoL differences within patients over time and between treatment groups. The Immune Thrombocytopenic Purpura (ITP)-Patient Assessment Questionnaire (PAQ) is the only comprehensive HRQoL questionnaire available for adults with ITP. Forty centers from within the US and Europe enrolled ITP patients into one of two multicenter, randomized, placebo-controlled, double-blind, 6-month, phase III clinical trials of romiplostim. Patients enrolled in these studies self-administered the ITP-PAQ and two items assessing global change (anchors) at baseline and weeks 4, 12, and 24. Using data from the ITP-PAQ and these two anchors, an anchor-based estimate was computed and combined with the standard error of measurement and standard deviation to compute a distribution-based estimate in order to provide an MID range for each of the 11 scales of the ITP-PAQ. A total of 125 patients participated in these clinical trials and provided data for use in these analyses. Combining results from anchor- and distribution-based approaches, MID values were computed for 9 of the 11 scales. MIDs ranged from 8 to 12 points for Symptoms, Bother, Psychological, Overall QOL, Social Activity, Menstrual Symptoms, and Fertility, while the range was 10 to 15 points for the Fatigue and Activity scales of the ITP-PAQ. These estimates, while slightly higher than other published MID estimates, were consistent with moderate effect sizes. These MID estimates will serve as a useful tool to researchers and clinicians using the ITP-PAQ, providing guidance for interpretation of baseline scores as well as changes in ITP-PAQ scores over time. Additional work should be done to finalize these initial estimates using more appropriate anchors that correlate more highly with the ITP-PAQ scales.

Making comparative performance information more comprehensible: an experimental evaluation of the impact of formats on consumer understanding

PubMed Central

Damman, Olga C; De Jong, Anco; Hibbard, Judith H; Timmermans, Danielle R M

2016-01-01

Study objectives We aimed to investigate how different presentation formats influence comprehension and use of comparative performance information (CPI) among consumers. Methods An experimental between-subjects and within-subjects design with manipulations of CPI presentation formats. We enrolled both consumers with lower socioeconomic status (SES)/cognitive skills and consumers with higher SES/cognitive skills, recruited through an online access panel. Respondents received fictitious CPI and completed questions about interpretation and information use. Between subjects, we tested (1) displaying an overall performance score (yes/no); (2) displaying a small number of quality indicators (5 vs 9); and (3) displaying different types of evaluative symbols (star ratings, coloured dots and word icons vs numbers and bar graphs). Within subjects, we tested the effect of a reduced number of healthcare providers (5 vs 20). Data were analysed using descriptive analysis, analyses of variance and paired-sampled t tests. Results A total of 902 (43%) respondents participated. Displaying an overall performance score and the use of coloured dots and word icons particularly enhanced consumer understanding. Importantly, respondents provided with coloured dots most often correctly selected the top three healthcare providers (84.3%), compared with word icons (76.6% correct), star ratings (70.6% correct), numbers (62.0%) and bars (54.2%) when viewing performance scores of 20 providers. Furthermore, a reduced number of healthcare providers appeared to support consumers, for example, when provided with 20 providers, 69.5% correctly selected the top three, compared with 80.2% with five providers. Discussion Particular presentation formats enhanced consumer understanding of CPI, most importantly the use of overall performance scores, word icons and coloured dots, and a reduced number of providers displayed. Public report efforts should use these formats to maximise impact on consumers. PMID:26543066

a Kml-Based Approach for Distributed Collaborative Interpretation of Remote Sensing Images in the Geo-Browser

NASA Astrophysics Data System (ADS)

Huang, L.; Zhu, X.; Guo, W.; Xiang, L.; Chen, X.; Mei, Y.

2012-07-01

Existing implementations of collaborative image interpretation have many limitations for very large satellite imageries, such as inefficient browsing, slow transmission, etc. This article presents a KML-based approach to support distributed, real-time, synchronous collaborative interpretation for remote sensing images in the geo-browser. As an OGC standard, KML (Keyhole Markup Language) has the advantage of organizing various types of geospatial data (including image, annotation, geometry, etc.) in the geo-browser. Existing KML elements can be used to describe simple interpretation results indicated by vector symbols. To enlarge its application, this article expands KML elements to describe some complex image processing operations, including band combination, grey transformation, geometric correction, etc. Improved KML is employed to describe and share interpretation operations and results among interpreters. Further, this article develops some collaboration related services that are collaboration launch service, perceiving service and communication service. The launch service creates a collaborative interpretation task and provides a unified interface for all participants. The perceiving service supports interpreters to share collaboration awareness. Communication service provides interpreters with written words communication. Finally, the GeoGlobe geo-browser (an extensible and flexible geospatial platform developed in LIESMARS) is selected to perform experiments of collaborative image interpretation. The geo-browser, which manage and visualize massive geospatial information, can provide distributed users with quick browsing and transmission. Meanwhile in the geo-browser, GIS data (for example DEM, DTM, thematic map and etc.) can be integrated to assist in improving accuracy of interpretation. Results show that the proposed method is available to support distributed collaborative interpretation of remote sensing image

SAM Gcms Chromatography Performed at Mars : Elements of Interpretation

NASA Astrophysics Data System (ADS)

Szopa, C.; Coll, P. J.; Buch, A.; François, P.; Cabane, M.; Coscia, D.; Teinturier, S.; Navarro-Gonzalez, R.; Glavin, D. P.; Freissinet, C.; Mahaffy, P. R.

2013-12-01

The characterisation of the chemical and mineralogical composition of regolith samples collected with the Curiosity rover is a primary objective of the SAM experiment. These data should provide essential clues on the past habitability of Gale crater. Interpretation of the data collected after SAM pyrolysis evolved gas analysis (EGA) and gas chromatography mass spectrometry (GC-MS) experiments on the first soil samples collected by MSL at the Rocknest Aeolian Deposit in Gale Crater has been challenging due to the concomitant presence in the ovens of an oxychlorine phase present in the samples, and a derivatization agent coming from the SAM wet chemistry experiment (Glavin et al., 2013). Moreover, accurate identification and quantification, in the SAM EGA mode, of volatiles released from the heated sample, or generated by reactions occurring in the SAM pyrolysis oven, is also difficult for a few compounds due to evolution over similar temperature ranges and overlap of their MS signatures. Hence, the GC analyses, coupled with MS, enabled the separation and identification and quantification of most of the volatile compounds detected. These results can have been obtained through tests and calibration done with GC individual spare components and with the SAM testbed. This paper will present a view of the interpretation of the chromatograms obtained when analyzing the Rocknest and John Klein solid samples delivered to SAM, on sols 96 and 199 respectively, supported by laboratory calibrations.

Post-ecological discourse in the making.

PubMed

Zeyer, Albert; Roth, Wolff-Michael

2013-01-01

This article analyses the discourse of 15- to16-year-old Swiss junior high school students in order to understand public discourse on the environment and environmental protection. Discourse analysis reveals four interpretive repertoires as the building blocks for the so-called post-ecological discourse, which can be used to describe important aspects of current ways of talking about ecological issues in Europe. We show that 10 theoretically identifiable dimensions of this discourse can be understood in terms of a mutual interplay between the four interpretive repertoires. Post-ecological discourse in today's (Swiss) society appears to be at its core a loss-of-control-discourse, which leads (in our students) to a latent eco-depression. Thus, the public understanding of science can be affected by unintended consequences of the talk itself (in this case an unintended environmental depression), that is, by the inherent characteristics of the involved repertoires, here especially the so-called folk science repertoire. Fostering public understanding of science is thus not merely a question of providing the public with scientific 'facts'. It is also an issue of paying attention to the available discursive repertoires. If necessary, viable alternative repertoires may have to be offered. In school, for example, conversations about the nature of science, and about complexity and applied ethics might help students learn new interpretive repertoires and how to mobilize these in talking about the environment and environmental protection.

A Critical Review on the Use of Support Values in Tree Viewers and Bioinformatics Toolkits.

PubMed

Czech, Lucas; Huerta-Cepas, Jaime; Stamatakis, Alexandros

2017-06-01

Phylogenetic trees are routinely visualized to present and interpret the evolutionary relationships of species. Most empirical evolutionary data studies contain a visualization of the inferred tree with branch support values. Ambiguous semantics in tree file formats can lead to erroneous tree visualizations and therefore to incorrect interpretations of phylogenetic analyses. Here, we discuss problems that arise when displaying branch values on trees after rerooting. Branch values are typically stored as node labels in the widely-used Newick tree format. However, such values are attributes of branches. Storing them as node labels can therefore yield errors when rerooting trees. This depends on the mostly implicit semantics that tools deploy to interpret node labels. We reviewed ten tree viewers and ten bioinformatics toolkits that can display and reroot trees. We found that 14 out of 20 of these tools do not permit users to select the semantics of node labels. Thus, unaware users might obtain incorrect results when rooting trees. We illustrate such incorrect mappings for several test cases and real examples taken from the literature. This review has already led to improvements in eight tools. We suggest tools should provide options that explicitly force users to define the semantics of node labels. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Analysing Key Debates in Education and Sustainable Development in Relation to ESD Practice in Viet Nam

ERIC Educational Resources Information Center

Balls, Emily

2016-01-01

This article is based on qualitative field research carried out in Ha Noi, Viet Nam, in 2013 for an MA dissertation in Education and International Development at the UCL Institute of Education. It analyses interpretations of education for sustainable development (ESD) in Viet Nam, relating these to key debates around instrumental and democratic…

An Exploration of the Validity and Potential of Adult Ego Development for Enhancing Understandings of School Leadership

ERIC Educational Resources Information Center

James, Chris; James, Jane; Potter, Ian

2017-01-01

An adult ego development (AED) perspective accepts that the way adults interpret and interact in the social world can change during their life-span. This article seeks to analyse the validity and potential of AED for enhancing understandings of educational leadership practice and development. We analysed the AED literature and interviewed 16…

A geochemical atlas of North Carolina, USA

USGS Publications Warehouse

Reid, J.C.

1993-01-01

A geochemical atlas of North Carolina, U.S.A., was prepared using National Uranium Resource Evaluation (NURE) stream-sediment data. Before termination of the NURE program, sampling of nearly the entire state (48,666 square miles of land area) was completed and geochemical analyses were obtained. The NURE data are applicable to mineral exploration, agriculture, waste disposal siting issues, health, and environmental studies. Applications in state government include resource surveys to assist mineral exploration by identifying geochemical anomalies and areas of mineralization. Agriculture seeks to identify areas with favorable (or unfavorable) conditions for plant growth, disease, and crop productivity. Trace elements such as cobalt, copper, chromium, iron, manganese, zinc, and molybdenum must be present within narrow ranges in soils for optimum growth and productivity. Trace elements as a contributing factor to disease are of concern to health professionals. Industry can use pH and conductivity data for water samples to site facilities which require specific water quality. The North Carolina NURE database consists of stream-sediment samples, groundwater samples, and stream-water analyses. The statewide database consists of 6,744 stream-sediment sites, 5,778 groundwater sample sites, and 295 stream-water sites. Neutron activation analyses were provided for U, Br, Cl, F, Mn, Na, Al, V, Dy in groundwater and stream water, and for U, Th, Hf, Ce, Fe, Mn, Na, Sc, Ti, V, Al, Dy, Eu, La, Sm, Yb, and Lu in stream sediments. Supplemental analyses by other techniques were reported on U (extractable), Ag, As, Ba, Be, Ca, Co, Cr, Cu, K, Li, Mg, Mo, Nb, Ni, P, Pb, Se, Sn, Sr, W, Y, and Zn for 4,619 stream-sediment samples. A small subset of 334 stream samples was analyzed for gold. The goal of the atlas was to make available the statewide NURE data with minimal interpretation to enable prospective users to modify and manipulate the data for their end use. The atlas provides only very general indication of geochemical distribution patterns and should not be used for site specific studies. The atlas maps for each element were computer-generated at the state's geographic information system (Center for Geographic Information and Analysis [CGIA]). The Division of Statistics and Information Services provided input files. The maps in the atlas are point maps. Each sample is represented by a symbol generally corresponding to a quartile class. Other reports will transmit sample and analytical data for state regions. Data are tentatively planned to be available on disks in spreadsheet format for personal computers. During the second phase of this project, stream-sediment samples are being assigned to state geologic map unit names using a GIS system to determine background and anomaly values. Subsequent publications will make this geochemical data and accompanying interpretations available to a wide spectrum of interdisciplinary users. ?? 1993.

Use of Health Care Claims Data to Study Patients with Ophthalmologic Conditions

PubMed Central

Stein, Joshua D.; Lum, Flora; Lee, Paul P.; Rich, William L.; Coleman, Anne L.

2014-01-01

Objective To describe what information is or is not included in health care claims data, provide an overview of the main advantages and limitations of performing analyses using health care claims data, and offer general guidance on how to report and interpret findings of ophthalmology-related claims data analyses. Design Systematic review. Participants Not applicable. Methods A literature review and synthesis of methods for claims-based data analyses. Main Outcome Measures Not applicable. Results Some advantages of using claims data for analyses include large, diverse sample sizes, longitudinal follow-up, lack of selection bias, and potential for complex, multivariable modeling. The disadvantages include (a) the inherent limitations of claims data, such as incomplete, inaccurate, or missing data, or the lack of specific billing codes for some conditions; and (b) the inability, in some circumstances, to adequately evaluate the appropriateness of care. In general, reports of claims data analyses should include clear descriptions of the following methodological elements: the data source, the inclusion and exclusion criteria, the specific billing codes used, and the potential confounding factors incorporated in the multivariable models. Conclusions The use of claims data for research is expected to increase with the enhanced availability of data from Medicare and other sources. The use of claims data to evaluate resource use and efficiency and to determine the basis for supplementary payment methods for physicians is anticipated. Thus, it will be increasingly important for eye care providers to use accurate and descriptive codes for billing. Adherence to general guidance on the reporting of claims data analyses, as outlined in this article, is important to enhance the credibility and applicability of findings. Guidance on optimal ways to conduct and report ophthalmology-related investigations using claims data will likely continue to evolve as health services researchers refine the metrics to analyze large administrative data sets. PMID:24433971

Dimerization of a flocculent protein from Moringa oleifera: experimental evidence and in silico interpretation.

PubMed

Pavankumar, Asalapuram R; Kayathri, Rajarathinam; Murugan, Natarajan A; Zhang, Qiong; Srivastava, Vaibhav; Okoli, Chuka; Bulone, Vincent; Rajarao, Gunaratna K; Ågren, Hans

2014-01-01

Many proteins exist in dimeric and other oligomeric forms to gain stability and functional advantages. In this study, the dimerization property of a coagulant protein (MO2.1) from Moringa oleifera seeds was addressed through laboratory experiments, protein-protein docking studies and binding free energy calculations. The structure of MO2.1 was predicted by homology modelling, while binding free energy and residues-distance profile analyses provided insight into the energetics and structural factors for dimer formation. Since the coagulation activities of the monomeric and dimeric forms of MO2.1 were comparable, it was concluded that oligomerization does not affect the biological activity of the protein.

A subgeneric classification of the genus Vaccinium and the metamorphosis of V. section Bracteata Nakai: more terrestrial and less epiphytic in habit, more continental and less insular in distribution.

PubMed

Vander Kloet, S P; Dickinson, T A

2009-05-01

The taxonomic integrity of Vaccinium section Bracteata sensu Sleumer was assessed using a variety of numerical measures on a data matrix created from 46 OTUs scored for 65 descriptors. These analyses supported a much restricted ambit for section Bracteata and the concomitant resurrection of section Nesococcus and section Euepigynium, a more cosmopolitan interpretation for section Eococcus and section Pyxothamnus as well as a new taxon, Vaccinium section Baccula-nigra Kloet, sect. nov. to accommodate V. fragile Franch. and its conspecifics. A key to all the sections as well as a brief description for each section is also provided.

Single molecule data under scrutiny. Comment on "Extracting physics of life at the molecular level: A review of single-molecule data analyses" by W. Colomb & S.K. Sarkar

NASA Astrophysics Data System (ADS)

Wohland, Thorsten

2015-06-01

Single Molecule Detection and Spectroscopy have grown from their first beginnings into mainstream, mature research areas that are widely applied in the biological sciences. However, despite the advances in technology and the application of many single molecule techniques even in in vivo settings, the data analysis of single molecule experiments is complicated by noise, systematic errors, and complex underlying processes that are only incompletely understood. Colomb and Sarkar provide in this issue an overview of single molecule experiments and the accompanying problems in data analysis, which have to be overcome for a proper interpretation of the experiments [1].

Mitochondria in anthropology and forensic medicine.

PubMed

Grzybowski, Tomasz; Rogalla, Urszula

2012-01-01

Mitochondria's role in crucial metabolic pathways is probably the first answer which comes to our minds for the question: what do these tiny organelles serve for? However, specific features of their DNA made them extremely useful also in the field of anthropology and forensics. MtDNA analyses became a milestone in the complex task of unraveling earliest human migrations. Evidence provided by these experiments left no doubts on modern humans origins pointing to Africa being our cradle. It also contributed to interpretation of putative ways of our dispersal around Asia and Americas thousands years ago. On the other hand, analysis of mtDNA is well established and valuable tool in forensic genetics. When other definitely more popular markers give no answer on identity, it is the time to employ information carried by mitochondria. This chapter summarizes not only current reports on the role of mitochondria in forensics and reconstruction of modern humans phylogeny, but also calls one's attention to a broad range of difficulties and constraints associated with mtDNA analyses.

Integrating public health and medical intelligence gathering into homeland security fusion centres.

PubMed

Lenart, Brienne; Albanese, Joseph; Halstead, William; Schlegelmilch, Jeffrey; Paturas, James

Homeland security fusion centres serve to gather, analyse and share threat-related information among all levels of governments and law enforcement agencies. In order to function effectively, fusion centres must employ people with the necessary competencies to understand the nature of the threat facing a community, discriminate between important information and irrelevant or merely interesting facts and apply domain knowledge to interpret the results to obviate or reduce the existing danger. Public health and medical sector personnel routinely gather, analyse and relay health-related inform-ation, including health security risks, associated with the detection of suspicious biological or chemical agents within a community to law enforcement agencies. This paper provides a rationale for the integration of public health and medical personnel in fusion centres and describes their role in assisting law enforcement agencies, public health organisations and the medical sector to respond to natural or intentional threats against local communities, states or the nation as a whole.

The Effect(s) of Teen Pregnancy: Reconciling Theory, Methods, and Findings.

PubMed

Diaz, Christina J; Fiel, Jeremy E

2016-02-01

Although teenage mothers have lower educational attainment and earnings than women who delay fertility, causal interpretations of this relationship remain controversial. Scholars argue that there are reasons to predict negative, trivial, or even positive effects, and different methodological approaches provide some support for each perspective. We reconcile this ongoing debate by drawing on two heuristics: (1) each methodological strategy emphasizes different women in estimation procedures, and (2) the effects of teenage fertility likely vary in the population. Analyses of the Child and Young Adult Cohorts of the National Longitudinal Survey of Youth (N = 3,661) confirm that teen pregnancy has negative effects on most women's attainment and earnings. More striking, however, is that effects on college completion and early earnings vary considerably and are most pronounced among those least likely to experience an early pregnancy. Further analyses suggest that teen pregnancy is particularly harmful for those with the brightest socioeconomic prospects and who are least prepared for the transition to motherhood.

Hypothesis for cognitive effects of transcranial direct current stimulation: Externally- and internally-directed cognition.

PubMed

Greenwood, Pamela M; Blumberg, Eric J; Scheldrup, Melissa R

2018-03-01

A comprehensive explanation is lacking for the broad array of cognitive effects modulated by transcranial direct current stimulation (tDCS). We advanced the testable hypothesis that tDCS to the default mode network (DMN) increases processing of goals and stored information at the expense of external events. We further hypothesized that tDCS to the dorsal attention network (DAN) increases processing of external events at the expense of goals and stored information. A literature search (PsychINFO) identified 42 empirical studies and 3 meta-analyses examining effects of prefrontal and/or parietal tDCS on tasks that selectively required external and/or internal processing. Most, though not all, of the studies that met our search criteria supported our hypothesis. Three meta-analyses supported our hypothesis. The hypothesis we advanced provides a framework for the design and interpretation of results in light of the role of large-scale intrinsic networks that govern attention. Copyright © 2017 Elsevier Ltd. All rights reserved.

Conducting Meta-Analyses Based on p Values

PubMed Central

van Aert, Robbie C. M.; Wicherts, Jelte M.; van Assen, Marcel A. L. M.

2016-01-01

Because of overwhelming evidence of publication bias in psychology, techniques to correct meta-analytic estimates for such bias are greatly needed. The methodology on which the p-uniform and p-curve methods are based has great promise for providing accurate meta-analytic estimates in the presence of publication bias. However, in this article, we show that in some situations, p-curve behaves erratically, whereas p-uniform may yield implausible estimates of negative effect size. Moreover, we show that (and explain why) p-curve and p-uniform result in overestimation of effect size under moderate-to-large heterogeneity and may yield unpredictable bias when researchers employ p-hacking. We offer hands-on recommendations on applying and interpreting results of meta-analyses in general and p-uniform and p-curve in particular. Both methods as well as traditional methods are applied to a meta-analysis on the effect of weight on judgments of importance. We offer guidance for applying p-uniform or p-curve using R and a user-friendly web application for applying p-uniform. PMID:27694466

Twitter discussions about the predicaments of robots in geriatric nursing: forecast of nursing robotics in aged care.

PubMed

Eriksson, Henrik; Salzmann-Erikson, Martin

2018-02-01

People use social media to express perceptions, attitudes and a wide range of concerns regarding human life. This study aims at analysing the ongoing discussions on the internet microblog Twitter and offers some coming predicaments regarding developments in geriatric nursing regarding nursing robots. Data were retrospectively collected from Twitter. 1322 mentions were included in the final analyses, where principles of interpreting data by using netnography were utilized. Many ideas are presented expressing functional, psychological and social aspects of robots in nursing care. Most postings come from metropolitan cities around the globe. The discussion focuses on market-driven, science fiction solutions for aged care. Twitter users overall seem to be positive using various nursing robots in aged care. These discussions offer a window into the attitudes and ideas of this group of users. We suggest that monitoring Twitter discussions on social media can provide valuable insights into current attitudes as well as forecast coming trends.

Supercomputer description of human lung morphology for imaging analysis.

PubMed

Martonen, T B; Hwang, D; Guan, X; Fleming, J S

1998-04-01

A supercomputer code that describes the three-dimensional branching structure of the human lung has been developed. The algorithm was written for the Cray C94. In our simulations, the human lung was divided into a matrix containing discrete volumes (voxels) so as to be compatible with analyses of SPECT images. The matrix has 3840 voxels. The matrix can be segmented into transverse, sagittal and coronal layers analogous to human subject examinations. The compositions of individual voxels were identified by the type and respective number of airways present. The code provides a mapping of the spatial positions of the almost 17 million airways in human lungs and unambiguously assigns each airway to a voxel. Thus, the clinician and research scientist in the medical arena have a powerful new tool to be used in imaging analyses. The code was designed to be integrated into diverse applications, including the interpretation of SPECT images, the design of inhalation exposure experiments and the targeted delivery of inhaled pharmacologic drugs.

Revealing the Hidden Language of Complex Networks

PubMed Central

Yaveroğlu, Ömer Nebil; Malod-Dognin, Noël; Davis, Darren; Levnajic, Zoran; Janjic, Vuk; Karapandza, Rasa; Stojmirovic, Aleksandar; Pržulj, Nataša

2014-01-01

Sophisticated methods for analysing complex networks promise to be of great benefit to almost all scientific disciplines, yet they elude us. In this work, we make fundamental methodological advances to rectify this. We discover that the interaction between a small number of roles, played by nodes in a network, can characterize a network's structure and also provide a clear real-world interpretation. Given this insight, we develop a framework for analysing and comparing networks, which outperforms all existing ones. We demonstrate its strength by uncovering novel relationships between seemingly unrelated networks, such as Facebook, metabolic, and protein structure networks. We also use it to track the dynamics of the world trade network, showing that a country's role of a broker between non-trading countries indicates economic prosperity, whereas peripheral roles are associated with poverty. This result, though intuitive, has escaped all existing frameworks. Finally, our approach translates network topology into everyday language, bringing network analysis closer to domain scientists. PMID:24686408

A Continental-Wide Perspective: The Genepool of Nuclear Encoded Ribosomal DNA and Single-Copy Gene Sequences in North American Boechera (Brassicaceae)

PubMed Central

Kiefer, Christiane; Koch, Marcus A.

2012-01-01

74 of the currently accepted 111 taxa of the North American genus Boechera (Brassicaceae) were subject to pyhlogenetic reconstruction and network analysis. The dataset comprised 911 accessions for which ITS sequences were analyzed. Phylogenetic analyses yielded largely unresolved trees. Together with the network analysis confirming this result this can be interpreted as an indication for multiple, independent, and rapid diversification events. Network analyses were superimposed with datasets describing i) geographical distribution, ii) taxonomy, iii) reproductive mode, and iv) distribution history based on phylogeographic evidence. Our results provide first direct evidence for enormous reticulate evolution in the entire genus and give further insights into the evolutionary history of this complex genus on a continental scale. In addition two novel single-copy gene markers, orthologues of the Arabidopsis thaliana genes At2g25920 and At3g18900, were analyzed for subsets of taxa and confirmed the findings obtained through the ITS data. PMID:22606266

Underserved Pregnant and Postpartum Women's Access and Use of Their Health Records.

PubMed

Guo, Yuqing; Hildebrand, Janet; Rousseau, Julie; Brown, Brandon; Pimentel, Pamela; Olshansky, Ellen

The purpose of this study was to examine knowledge of and experiences with use of their electronic health record (EHR) among mostly Hispanic women during pregnancy and postpartum. Women who were in the MOMS Orange County prenatal or postpartum home visitation program completed surveys and participated in focus groups. Descriptive and content analyses were used. Twenty-six women participated. Nearly all women (24, 92.3%) knew what health records were and most (80.8%) felt that keeping their records would increase or greatly increase their confidence in caring for themselves and their families. Approximately one third reported already keeping a copy of their health records. Common barriers to accessing and understanding health records included healthcare providers' noncompliance with the Health Information Technology for Economic and Clinical Health Act, limited EHR adoption, unfriendly patient portals, complicated medical terminology, rushed appointments with healthcare providers, lack of Spanish interpreters, and lack of Spanish-speaking healthcare providers. Programs are needed to educate and support women and providers in using health records to promote health literacy, pregnancy management, and patient-provider relationships in underserved populations.

Assessment of self-organizing maps to analyze sole-carbon source utilization profiles.

PubMed

Leflaive, Joséphine; Céréghino, Régis; Danger, Michaël; Lacroix, Gérard; Ten-Hage, Loïc

2005-07-01

The use of community-level physiological profiles obtained with Biolog microplates is widely employed to consider the functional diversity of bacterial communities. Biolog produces a great amount of data which analysis has been the subject of many studies. In most cases, after some transformations, these data were investigated with classical multivariate analyses. Here we provided an alternative to this method, that is the use of an artificial intelligence technique, the Self-Organizing Maps (SOM, unsupervised neural network). We used data from a microcosm study of algae-associated bacterial communities placed in various nutritive conditions. Analyses were carried out on the net absorbances at two incubation times for each substrates and on the chemical guild categorization of the total bacterial activity. Compared to Principal Components Analysis and cluster analysis, SOM appeared as a valuable tool for community classification, and to establish clear relationships between clusters of bacterial communities and sole-carbon sources utilization. Specifically, SOM offered a clear bidimensional projection of a relatively large volume of data and were easier to interpret than plots commonly obtained with multivariate analyses. They would be recommended to pattern the temporal evolution of communities' functional diversity.

Electrostatically confined nanoparticle interactions and dynamics.

PubMed

Eichmann, Shannon L; Anekal, Samartha G; Bevan, Michael A

2008-02-05

We report integrated evanescent wave and video microscopy measurements of three-dimensional trajectories of 50, 100, and 250 nm gold nanoparticles electrostatically confined between parallel planar glass surfaces separated by 350 and 600 nm silica colloid spacers. Equilibrium analyses of single and ensemble particle height distributions normal to the confining walls produce net electrostatic potentials in excellent agreement with theoretical predictions. Dynamic analyses indicate lateral particle diffusion coefficients approximately 30-50% smaller than expected from predictions including the effects of the equilibrium particle distribution within the gap and multibody hydrodynamic interactions with the confining walls. Consistent analyses of equilibrium and dynamic information in each measurement do not indicate any roles for particle heating or hydrodynamic slip at the particle or wall surfaces, which would both increase diffusivities. Instead, lower than expected diffusivities are speculated to arise from electroviscous effects enhanced by the relative extent (kappaa approximately 1-3) and overlap (kappah approximately 2-4) of electrostatic double layers on the particle and wall surfaces. These results demonstrate direct, quantitative measurements and a consistent interpretation of metal nanoparticle electrostatic interactions and dynamics in a confined geometry, which provides a basis for future similar measurements involving other colloidal forces and specific biomolecular interactions.

Expressing and amplifying positive emotions facilitate goal attainment in workplace interactions.

PubMed

Wong, Elena; Tschan, Franziska; Messerli, Laurence; Semmer, Norbert K

2013-01-01

Expressing emotions has social functions; it provides information, affects social interactions, and shapes relationships with others. Expressing positive emotions could be a strategic tool for improving goal attainment during social interactions at work. Such effects have been found in research on social contagion, impression management, and emotion work. However, expressing emotions one does not feel entails the risk of being perceived as inauthentic. This risk may well be worth taking when the emotions felt are negative, as expressing negative emotions usually has negative effects. When experiencing positive emotions, however, expressing them authentically promises benefits, and the advantage of amplifying them is not so obvious. We postulated that expressing, and amplifying, positive emotions would foster goal attainment in social interactions at work, particularly when dealing with superiors. Analyses are based on 494 interactions involving the pursuit of a goal by 113 employes. Multilevel analyses, including polynomial analyses, show that authentic display of positive emotions supported goal attainment throughout. However, amplifying felt positive emotions promoted goal attainment only in interactions with superiors, but not with colleagues. Results are discussed with regard to the importance of hierarchy for detecting, and interpreting, signs of strategic display of positive emotions.

Expressing and Amplifying Positive Emotions Facilitate Goal Attainment in Workplace Interactions

PubMed Central

Wong, Elena; Tschan, Franziska; Messerli, Laurence; Semmer, Norbert K.

2013-01-01

Expressing emotions has social functions; it provides information, affects social interactions, and shapes relationships with others. Expressing positive emotions could be a strategic tool for improving goal attainment during social interactions at work. Such effects have been found in research on social contagion, impression management, and emotion work. However, expressing emotions one does not feel entails the risk of being perceived as inauthentic. This risk may well be worth taking when the emotions felt are negative, as expressing negative emotions usually has negative effects. When experiencing positive emotions, however, expressing them authentically promises benefits, and the advantage of amplifying them is not so obvious. We postulated that expressing, and amplifying, positive emotions would foster goal attainment in social interactions at work, particularly when dealing with superiors. Analyses are based on 494 interactions involving the pursuit of a goal by 113 employes. Multilevel analyses, including polynomial analyses, show that authentic display of positive emotions supported goal attainment throughout. However, amplifying felt positive emotions promoted goal attainment only in interactions with superiors, but not with colleagues. Results are discussed with regard to the importance of hierarchy for detecting, and interpreting, signs of strategic display of positive emotions. PMID:23675358

Geomorphology, tectonics, and exploration

NASA Technical Reports Server (NTRS)

Sabins, F. F., Jr.

1985-01-01

Explorationists interpret satellite images for tectonic features and patterns that may be clues to mineral and energy deposits. The tectonic features of interest range in scale from regional (sedimentary basins, fold belts) to local (faults, fractures) and are generally expressed as geomorphic features in remote sensing images. Explorationists typically employ classic concepts of geomorphology and landform analysis for their interpretations, which leads to the question - Are there new and evolving concepts in geomorphology that may be applicable to tectonic analyses of images?

U-interpreter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arvind; Gostelow, K.P.

1982-02-01

The author argues that by giving a unique name to every activity generated during a computation, the u-interpreter can provide greater concurrency in the interpretation of data flow graphs. 19 references.

The 'radiographer-referrer game': image interpretation dynamics in rural practice.

PubMed

Squibb, Kathryn; Smith, Anthony; Dalton, Lisa; Bull, Rosalind M

2016-03-01

Effective interprofessional communication is intrinsic to safe health care. Despite the identified positive impact of collaborative radiographic interpretation between rural radiographers and referrers, communication difficulties still exist. This article describes the strategies that Australian rural radiographers use for communication of their radiographic opinion to the referring doctor. In a two-phase interpretive doctoral study completed in 2012, data were collected from radiographers working in rural New South Wales, Western Australia and Tasmania using a paper based questionnaire followed by in-depth semistructured interviews. Data were analysed thematically in order to identify, analyse and report the emergent themes. The overarching theme was Patient Advocacy, where in the interest of patient care radiographers took measures to ensure that a referring doctor did not miss radiographic abnormalities. Strong interprofessional relationships enabled direct communication pathways. Interprofessional boundaries shaped by historical hierarchical relationships, together with a lack of confidence and educational preparation for radiographic interpretation result in barriers to direct communication pathways. These barriers prompted radiographers to pursue indirect communication pathways, such as side-stepping and hint and hope. A lack of formal communication pathways and educational preparation for this role has resulted in radiographers playing the radiographer-referrer game to overtly or covertly assist referrers in reaching a radiographic diagnosis. The findings from this study may be used to plan interventions for strengthening interprofessional communication pathways and improve quality of healthcare for patients.

Doubly blind: a systematic review of gender in randomised controlled trials

PubMed Central

Phillips, Susan P; Hamberg, Katarina

2016-01-01

Background Although observational data show social characteristics such as gender or socio-economic status to be strong predictors of health, their impact is seldom investigated in randomised controlled studies (RCTs). Objective & design Using a random sample of recent RCTs from high-impact journals, we examined how the most often recorded social characteristic, sex/gender, is considered in design, analysis, and interpretation. Of 712 RCTs published from September 2008 to 31 December 2013 in the Annals of Internal Medicine, British Medical Journal, Lancet, Canadian Medical Association Journal, or New England Journal of Medicine, we randomly selected 57 to analyse funding, methods, number of centres, documentation of social circumstances, inclusion/exclusion criteria, proportions of women/men, and reporting about sex/gender in analyses and discussion. Results Participants’ sex was recorded in most studies (52/57). Thirty-nine percent included men and women approximately equally. Overrepresentation of men in 43% of studies without explicit exclusions for women suggested interference in selection processes. The minority of studies that did analyse sex/gender differences (22%) did not discuss or reflect upon these, or dismissed significant findings. Two studies reinforced traditional beliefs about women's roles, finding no impact of breastfeeding on infant health but nevertheless reporting possible benefits. Questionable methods such as changing protocols mid-study, having undefined exclusion criteria, allowing local researchers to remove participants from studies, and suggesting possible benefit where none was found were evident, particularly in industry-funded research. Conclusions Social characteristics like sex/gender remain hidden from analyses and interpretation in RCTs, with loss of information and embedding of error all along the path from design to interpretation, and therefore, to uptake in clinical practice. Our results suggest that to broaden external validity, in particular, more refined trial designs and analyses that account for sex/gender and other social characteristics are needed. PMID:27087576

Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies.

PubMed

Ponce, Rafael; Abad, Leslie; Amaravadi, Lakshmi; Gelzleichter, Thomas; Gore, Elizabeth; Green, James; Gupta, Shalini; Herzyk, Danuta; Hurst, Christopher; Ivens, Inge A; Kawabata, Thomas; Maier, Curtis; Mounho, Barbara; Rup, Bonita; Shankar, Gopi; Smith, Holly; Thomas, Peter; Wierda, Dan

2009-07-01

An evaluation of potential antibody formation to biologic therapeutics during the course of nonclinical safety studies and its impact on the toxicity profile is expected under current regulatory guidance and is accepted standard practice. However, approaches for incorporating this information in the interpretation of nonclinical safety studies are not clearly established. Described here are the immunological basis of anti-drug antibody formation to biopharmaceuticals (immunogenicity) in laboratory animals, and approaches for generating and interpreting immunogenicity data from nonclinical safety studies of biotechnology-derived therapeutics to support their progression to clinical evaluation. We subscribe that immunogenicity testing strategies should be adapted to the specific needs of each therapeutic development program, and data generated from such analyses should be integrated with available clinical and anatomic pathology, pharmacokinetic, and pharmacodynamic data to properly interpret nonclinical studies.

Inter-Rater Reliability of Provider Interpretations of Irritable Bowel Syndrome Food and Symptom Journals

PubMed Central

Chung, Chia-Fang; Xu, Kaiyuan; Dong, Yi; Schenk, Jeanette M.; Cain, Kevin; Munson, Sean; Heitkemper, Margaret M.

2017-01-01

There are currently no standardized methods for identifying trigger food(s) from irritable bowel syndrome (IBS) food and symptom journals. The primary aim of this study was to assess the inter-rater reliability of providers’ interpretations of IBS journals. A second aim was to describe whether these interpretations varied for each patient. Eight providers reviewed 17 IBS journals and rated how likely key food groups (fermentable oligo-di-monosaccharides and polyols, high-calorie, gluten, caffeine, high-fiber) were to trigger IBS symptoms for each patient. Agreement of trigger food ratings was calculated using Krippendorff’s α-reliability estimate. Providers were also asked to write down recommendations they would give to each patient. Estimates of agreement of trigger food likelihood ratings were poor (average α = 0.07). Most providers gave similar trigger food likelihood ratings for over half the food groups. Four providers gave the exact same written recommendation(s) (range 3–7) to over half the patients. Inter-rater reliability of provider interpretations of IBS food and symptom journals was poor. Providers favored certain trigger food likelihood ratings and written recommendations. This supports the need for a more standardized method for interpreting these journals and/or more rigorous techniques to accurately identify personalized IBS food triggers. PMID:29113044

Cued Speech Transliteration: Effects of Speaking Rate and Lag Time on Production Accuracy

ERIC Educational Resources Information Center

Krause, Jean C.; Tessler, Morgan P.

2016-01-01

Many deaf and hard-of-hearing children rely on interpreters to access classroom communication. Although the exact level of access provided by interpreters in these settings is unknown, it is likely to depend heavily on interpreter accuracy (portion of message correctly produced by the interpreter) and the factors that govern interpreter accuracy.…

Using American sign language interpreters to facilitate research among deaf adults: lessons learned.

PubMed

Sheppard, Kate

2011-04-01

Health care providers commonly discuss depressive symptoms with clients, enabling earlier intervention. Such discussions rarely occur between providers and Deaf clients. Most culturally Deaf adults experience early-onset hearing loss, self-identify as part of a unique culture, and communicate in the visual language of American Sign Language (ASL). Communication barriers abound, and depression screening instruments may be unreliable. To train and use ASL interpreters for a qualitative study describing depressive symptoms among Deaf adults. Training included research versus community interpreting. During data collection, interpreters translated to and from voiced English and ASL. Training eliminated potential problems during data collection. Unexpected issues included participants asking for "my interpreter" and worrying about confidentiality or friendship in a small community. Lessons learned included the value of careful training of interpreters prior to initiating data collection, including resolution of possible role conflicts and ensuring conceptual equivalence in real-time interpreting.

Training interpretation biases among individuals with body dysmorphic disorder symptoms.

PubMed

Premo, Julie E; Sarfan, Laurel D; Clerkin, Elise M

2016-03-01

The current study provided an initial test of a Cognitive Bias Modification for Interpretations (CBM-I) training paradigm among a sample with elevated BDD symptoms (N=86). As expected, BDD-relevant interpretations were reduced among participants who completed a positive (vs. comparison) training program. Results also pointed to the intriguing possibility that modifying biased appearance-relevant interpretations is causally related to changes in biased, socially relevant interpretations. Further, providing support for cognitive behavioral models, residual change in interpretations was associated with some aspects of in vivo stressor responding. However, contrary to expectations there were no significant effects of condition on emotional vulnerability to a BDD stressor, potentially because participants in both training conditions experienced reductions in biased socially-threatening interpretations following training (suggesting that the "comparison" condition was not inert). These findings have meaningful theoretical and clinical implications, and fit with transdiagnostic conceptualizations of psychopathology. Copyright © 2015 Elsevier Ltd. All rights reserved.

Personalized genomic analyses for cancer mutation discovery and interpretation

PubMed Central

Jones, Siân; Anagnostou, Valsamo; Lytle, Karli; Parpart-Li, Sonya; Nesselbush, Monica; Riley, David R.; Shukla, Manish; Chesnick, Bryan; Kadan, Maura; Papp, Eniko; Galens, Kevin G.; Murphy, Derek; Zhang, Theresa; Kann, Lisa; Sausen, Mark; Angiuoli, Samuel V.; Diaz, Luis A.; Velculescu, Victor E.

2015-01-01

Massively parallel sequencing approaches are beginning to be used clinically to characterize individual patient tumors and to select therapies based on the identified mutations. A major question in these analyses is the extent to which these methods identify clinically actionable alterations and whether the examination of the tumor tissue alone is sufficient or whether matched normal DNA should also be analyzed to accurately identify tumor-specific (somatic) alterations. To address these issues, we comprehensively evaluated 815 tumor-normal paired samples from patients of 15 tumor types. We identified genomic alterations using next-generation sequencing of whole exomes or 111 targeted genes that were validated with sensitivities >95% and >99%, respectively, and specificities >99.99%. These analyses revealed an average of 140 and 4.3 somatic mutations per exome and targeted analysis, respectively. More than 75% of cases had somatic alterations in genes associated with known therapies or current clinical trials. Analyses of matched normal DNA identified germline alterations in cancer-predisposing genes in 3% of patients with apparently sporadic cancers. In contrast, a tumor-only sequencing approach could not definitively identify germline changes in cancer-predisposing genes and led to additional false-positive findings comprising 31% and 65% of alterations identified in targeted and exome analyses, respectively, including in potentially actionable genes. These data suggest that matched tumor-normal sequencing analyses are essential for precise identification and interpretation of somatic and germline alterations and have important implications for the diagnostic and therapeutic management of cancer patients. PMID:25877891

What did we do and what can we do with our global soil resources?

NASA Astrophysics Data System (ADS)

Stoorvogel, Jetse

2017-04-01

Our global soil resources increasingly meet the headlines: soil degradation leads to irreversible changes and a loss of the global production potential, soil resources play a key role to reach the sustainable development goals, and soils are seen as a potential solution to some of the climate change mitigation through carbon sequestration. However, global assessments of soil degradation, soil resources, and the potential of soils to provide ecosystem services are not very consistent. This study aims to contribute to the discussion by providing a realistic opportunity space on the options for our soil resources. First, the natural and current soil conditions are estimated using the S-World methodology. S-World has been developed to provide global maps of soil properties at a 30 arc-second resolution for environmental modelling. By running the S-world methodology for current but also for natural land cover, natural and current soil conditions are estimated. This analysis tells us what we did to our global soil resources. Subsequently, the same methodology is used to analyse a range of different scenarios for the future to explore the potential for soil restoration and carbon sequestration. Although the actual management interventions required are not analysed, the analysis does provide the opportunity space and thus what we can do with our soil resources in terms of realistic ranges. The results are interpreted in the context of the Sustainable Development Goals and the recent 4‰-initiative for climate change mitigation.

Omics Metadata Management Software (OMMS).

PubMed

Perez-Arriaga, Martha O; Wilson, Susan; Williams, Kelly P; Schoeniger, Joseph; Waymire, Russel L; Powell, Amy Jo

2015-01-01

Next-generation sequencing projects have underappreciated information management tasks requiring detailed attention to specimen curation, nucleic acid sample preparation and sequence production methods required for downstream data processing, comparison, interpretation, sharing and reuse. The few existing metadata management tools for genome-based studies provide weak curatorial frameworks for experimentalists to store and manage idiosyncratic, project-specific information, typically offering no automation supporting unified naming and numbering conventions for sequencing production environments that routinely deal with hundreds, if not thousands of samples at a time. Moreover, existing tools are not readily interfaced with bioinformatics executables, (e.g., BLAST, Bowtie2, custom pipelines). Our application, the Omics Metadata Management Software (OMMS), answers both needs, empowering experimentalists to generate intuitive, consistent metadata, and perform analyses and information management tasks via an intuitive web-based interface. Several use cases with short-read sequence datasets are provided to validate installation and integrated function, and suggest possible methodological road maps for prospective users. Provided examples highlight possible OMMS workflows for metadata curation, multistep analyses, and results management and downloading. The OMMS can be implemented as a stand alone-package for individual laboratories, or can be configured for webbased deployment supporting geographically-dispersed projects. The OMMS was developed using an open-source software base, is flexible, extensible and easily installed and executed. The OMMS can be obtained at http://omms.sandia.gov. The OMMS can be obtained at http://omms.sandia.gov.

Omics Metadata Management Software (OMMS)

PubMed Central

Perez-Arriaga, Martha O; Wilson, Susan; Williams, Kelly P; Schoeniger, Joseph; Waymire, Russel L; Powell, Amy Jo

2015-01-01

Next-generation sequencing projects have underappreciated information management tasks requiring detailed attention to specimen curation, nucleic acid sample preparation and sequence production methods required for downstream data processing, comparison, interpretation, sharing and reuse. The few existing metadata management tools for genome-based studies provide weak curatorial frameworks for experimentalists to store and manage idiosyncratic, project-specific information, typically offering no automation supporting unified naming and numbering conventions for sequencing production environments that routinely deal with hundreds, if not thousands of samples at a time. Moreover, existing tools are not readily interfaced with bioinformatics executables, (e.g., BLAST, Bowtie2, custom pipelines). Our application, the Omics Metadata Management Software (OMMS), answers both needs, empowering experimentalists to generate intuitive, consistent metadata, and perform analyses and information management tasks via an intuitive web-based interface. Several use cases with short-read sequence datasets are provided to validate installation and integrated function, and suggest possible methodological road maps for prospective users. Provided examples highlight possible OMMS workflows for metadata curation, multistep analyses, and results management and downloading. The OMMS can be implemented as a stand alone-package for individual laboratories, or can be configured for webbased deployment supporting geographically-dispersed projects. The OMMS was developed using an open-source software base, is flexible, extensible and easily installed and executed. The OMMS can be obtained at http://omms.sandia.gov. Availability The OMMS can be obtained at http://omms.sandia.gov PMID:26124554