Science.gov

Sample records for purpose research complex

  1. Improving Education through Research? From Effectiveness, Causality and Technology to Purpose, Complexity and Culture

    ERIC Educational Resources Information Center

    Biesta, Gert

    2016-01-01

    This paper focuses on the role of research in the improvement of educational practice. I use the "10 Principles for Effective Pedagogy," which were formulated on the basis of research conducted in the UK's Teacher and Learning Research Programme as an example to highlight some common problems in the discussion about research and…

  2. Researching Complexity.

    ERIC Educational Resources Information Center

    Sumara, Dennis J.

    2000-01-01

    Discusses what Complexity Theory (presented as a rubric that collects theoretical understandings from a number of domains such as ecology, biology, neurology, and education) suggests about mind, selfhood, intelligence, and practices of reading, and the import of these reconceptualizations to reader-response researchers. Concludes that developing…

  3. Researching Complexity.

    ERIC Educational Resources Information Center

    Sumara, Dennis J.

    2000-01-01

    Discusses what Complexity Theory (presented as a rubric that collects theoretical understandings from a number of domains such as ecology, biology, neurology, and education) suggests about mind, selfhood, intelligence, and practices of reading, and the import of these reconceptualizations to reader-response researchers. Concludes that developing…

  4. Purposive Sampling in Clinical Research.

    ERIC Educational Resources Information Center

    Royeen, Charlotte Brasic; Fortune, Jim Carlton

    This paper identifies typical sampling problems, including improper application of the Central Limit Theorem, that are associated with the probability-based sampling procedures currently used in clinical psychology research. It then presents two alternative research designs, the theory validation model and the extended case study model, which…

  5. Teaching Research for Academic Purposes

    ERIC Educational Resources Information Center

    Pashaie, Billy

    2010-01-01

    Teaching the ability to find, analyze, evaluate, and synthesize information is an important part of creating an environment in which ESL students feel empowered in the information age. However, a preliminary search of professional literature shows that there is a lack of research in information-literacy programs for ESL learners in higher…

  6. [Accessing medical records for research purposes].

    PubMed

    Alcalde Bezhold, Guillermo; Alfonso Farnós, Iciar

    2013-01-01

    The Organic Law 15/1999 of 13 December on the Protection of Personal Data and the Law 41/2002 of 14 November regulating patient autonomy and rights and obligations of information and clinical documentation are the basic rules which govern the medical history in Spain. However, the lack of development of these laws regarding data protection in clinical research, particularly in terms of access to the medical history, repeatedly causes doubts about its construction by the Research Ethics Committees. Therefore, the aim of this paper is to analyze the rules which govern the access to the medical history for research purposes, with particular emphasis on the common problems that arise in the Committees for the ethical evaluation of these projects and finally setting a series of recommendations. The use for research purpose of genetic personal data contained in the medical history is also addressed in this paper. In this sense, a key contribution of the Law on Biomedical Research is relating to the specific regulation of the genetic personal data, both with respect to their production and access to the data as a support and regarding to its use for research purpose.

  7. Pseudonymisation of radiology data for research purposes

    NASA Astrophysics Data System (ADS)

    Noumeir, Rita; Lemay, Alain; Lina, Jean-Marc

    2005-04-01

    Medical image processing methods and algorithms, developed by researchers, need to be validated and tested. Test data should ideally be real clinical data especially when that clinical data is varied and exists in large volume. In nowadays, clinical data is accessible electronically and has important value for researchers. However, the usage of clinical data for research purposes should respect data confidentiality, patient right to privacy and the patient consent. In fact, clinical data is nominative given that it contains information about the patient such as name, age and identification number. Evidently, clinical data should be de-identified to be exported to research databases. However, the same patient is usually followed during a long period of time. The disease progression and the diagnostic evolution represent extremely valuable information for researchers, as well. Our objective is to build a research database from de-identified clinical data while enabling the database to be easily incremented by exporting new pseudonymous data, acquired over a long period of time. Pseudonymisation is data de-identification such that data belonging to the same individual in the clinical environment bear the same relation to each other in the de-identified research version. In this paper, we propose a software architecture that enables the implementation of a research database that can be incremented in time. We also evaluate its security and discuss its security pitfalls.

  8. Pseudonymization of radiology data for research purposes.

    PubMed

    Noumeir, Rita; Lemay, Alain; Lina, Jean-Marc

    2007-09-01

    Medical image processing methods and algorithms, developed by researchers, need to be validated and tested. Test data would ideally be real clinical data especially that clinical data is varied and exists in large volumes. Nowadays, clinical data is accessible electronically and has important value for researchers. However, the usage of clinical data for research purposes should respect data confidentiality, patient right to privacy, and patient consent. In fact, clinical data is nominative given that it contains information about the patient such as name, age, and identification number. Evidently, clinical data needs to be de-identified to be exported to research databases. However, the same patient is usually followed during a long period of time. The disease progression and the diagnostic evolution represent extremely valuable information for researchers as well. Our objective is to build a research database from de-identified clinical data while enabling the data set to be easily incremented by exporting new pseudonymous data, acquired over a long period of time. Pseudonymization is data de-identification, such that data belonging to an individual in the clinical environment still belong to the same individual in the de-identified research version. In this paper, we explore various software architectures to enable the implementation of an imaging research database that can be incremented in time. We also evaluate their security and discuss their security pitfalls. As most imaging data accessible electronically is available with the digital imaging and communication in medicine (DICOM) standard, we propose a de-identification scheme that closely follows DICOM recommendations. Our work can be used to enable electronic health record (EHR) secondary usage such as public surveillance and research, while maintaining patient confidentiality.

  9. Insect societies as divided organisms: The complexities of purpose and cross-purpose

    PubMed Central

    Strassmann, Joan E.; Queller, David C.

    2007-01-01

    Individual organisms are complex in a special way. The organization and function of their parts seem directed toward a purpose: the survival and reproduction of that individual. Groups of organisms are different. They may also be complex, but that is usually because their parts, the individual organisms, are working at cross-purposes. The most obvious exception to this rule is the social insects. Here, the individuals cooperate in complex ways toward the common goal of the success of the colony, even if it means that most of them do not reproduce. Kin selection theory explains how this can evolve. Nonreproductive individuals help in the reproduction of their kin, who share and transmit their genes. Such help is most favored when individuals can give more to their kin than they give up by not reproducing directly. For example, they can remain at their natal site and help defend a valuable resource (“fortress defenders”), or they can ensure that at least one adult survives to care for helpless young (“life insurers”). Although kin selection explains the extensive cooperation and common purpose of social insect colonies, it also predicts a certain amount of cross-purpose and conflict behavior. Kin selection has predicted how workers and queens disagree over sex ratios, how potential queens struggle to be the colony's head, how workers try to produce sons, and how other workers often prevent them. Kin selection analysis of cooperation and conflict in social insects is one of the outstanding achievements of evolutionary theory. PMID:17494750

  10. Building on Treacherous Ground: Sense-of-Purpose Research and Demarcating Problematic Purposes

    ERIC Educational Resources Information Center

    Waddington, David I.

    2010-01-01

    Developmental psychologist Damon's (Damon, Menon, & Cotton Bronk, 2003) ongoing research program on youth purpose may have important practical implications for education. However, in the course of the development of this research, two fundamental conceptual questions have not yet been resolved satisfactorily: (a) How should "sense of purpose" be…

  11. Building on Treacherous Ground: Sense-of-Purpose Research and Demarcating Problematic Purposes

    ERIC Educational Resources Information Center

    Waddington, David I.

    2010-01-01

    Developmental psychologist Damon's (Damon, Menon, & Cotton Bronk, 2003) ongoing research program on youth purpose may have important practical implications for education. However, in the course of the development of this research, two fundamental conceptual questions have not yet been resolved satisfactorily: (a) How should "sense of purpose" be…

  12. 38 CFR 17.92 - Outpatient care for research purposes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... research purposes. 17.92 Section 17.92 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Outpatient Treatment § 17.92 Outpatient care for research purposes. Subject to the... the treatment to be rendered is part of an approved Department of Veterans Affairs research...

  13. 38 CFR 17.92 - Outpatient care for research purposes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... research purposes. 17.92 Section 17.92 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Outpatient Treatment § 17.92 Outpatient care for research purposes. Subject to the... the treatment to be rendered is part of an approved Department of Veterans Affairs research...

  14. 38 CFR 17.92 - Outpatient care for research purposes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... research purposes. 17.92 Section 17.92 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Outpatient Treatment § 17.92 Outpatient care for research purposes. Subject to the... the treatment to be rendered is part of an approved Department of Veterans Affairs research...

  15. 38 CFR 17.92 - Outpatient care for research purposes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research purposes. 17.92 Section 17.92 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Outpatient Treatment § 17.92 Outpatient care for research purposes. Subject to the... the treatment to be rendered is part of an approved Department of Veterans Affairs research...

  16. 38 CFR 17.45 - Hospital care for research purposes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Hospital care for research purposes. 17.45 Section 17.45 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Hospital, Domiciliary and Nursing Home Care § 17.45 Hospital care for research purposes...

  17. 38 CFR 17.45 - Hospital care for research purposes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Hospital care for research purposes. 17.45 Section 17.45 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Hospital, Domiciliary and Nursing Home Care § 17.45 Hospital care for research purposes...

  18. 38 CFR 17.45 - Hospital care for research purposes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Hospital care for research purposes. 17.45 Section 17.45 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Hospital, Domiciliary and Nursing Home Care § 17.45 Hospital care for research purposes...

  19. 38 CFR 17.45 - Hospital care for research purposes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Hospital care for research purposes. 17.45 Section 17.45 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Hospital, Domiciliary and Nursing Home Care § 17.45 Hospital care for research purposes...

  20. 38 CFR 17.45 - Hospital care for research purposes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Hospital care for research purposes. 17.45 Section 17.45 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Hospital, Domiciliary and Nursing Home Care § 17.45 Hospital care for research purposes...

  1. Qualitative research sampling: the very real complexities.

    PubMed

    Tuckett, Anthony G

    2004-01-01

    In this article Anthony Tuckett discusses the complexities of qualitative research sampling. He analyses a research experience, together with the rationales for and limitations of qualitative research sampling. Further, he examines the reality of establishing and maintaining a purposeful/theoretical sample and how data saturation symbiotically interacts with constant comparison to guide sampling. Additionally sample limitations are countered. This paper is aimed at novice and experienced researchers in nursing interested in the practical reality of research, who are also mindful of the necessity for rigour.

  2. Tidying the Territory: Questioning Terms and Purposes in Work-Learning Research

    ERIC Educational Resources Information Center

    Fenwick, Tara

    2006-01-01

    Purpose: The purpose of this paper is to argue that foundational terms in work-learning research, specifically "learning", "work", and "workplace", are inherently complex and contested as the same as their scope has expanded in different fields to elide various conceptual categories and theoretical positions. Yet…

  3. Applying Research to Enhance Capacity: A Unifying Purpose for an Integrated Profession

    ERIC Educational Resources Information Center

    Keenan, Elizabeth King

    2016-01-01

    For more than a century the social work profession has had a dual purpose: to promote individual well-being and social justice, but the micro-macro divide is fragmenting the profession. This article suggests that the profession's aim might best be realized by adopting a unifying purpose, a just sense of well-being. Research on complex adaptive…

  4. Applying Research to Enhance Capacity: A Unifying Purpose for an Integrated Profession

    ERIC Educational Resources Information Center

    Keenan, Elizabeth King

    2016-01-01

    For more than a century the social work profession has had a dual purpose: to promote individual well-being and social justice, but the micro-macro divide is fragmenting the profession. This article suggests that the profession's aim might best be realized by adopting a unifying purpose, a just sense of well-being. Research on complex adaptive…

  5. 5 CFR 470.201 - Purposes of research programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... conducting personnel management research; or (g) Designs systems for the assessment and transmittal of... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Purposes of research programs. 470.201 Section 470.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS...

  6. A Small Acoustic Goniometer for General Purpose Research

    PubMed Central

    Pook, Michael L.; Loo, Sin Ming

    2016-01-01

    Understanding acoustic events and monitoring their occurrence is a useful aspect of many research projects. In particular, acoustic goniometry allows researchers to determine the source of an event based solely on the sound it produces. The vast majority of acoustic goniometry research projects used custom hardware targeted to the specific application under test. Unfortunately, due to the wide range of sensing applications, a flexible general purpose hardware/firmware system does not exist for this purpose. This article focuses on the development of such a system which encourages the continued exploration of general purpose hardware/firmware and lowers barriers to research in projects requiring the use of acoustic goniometry. Simulations have been employed to verify system feasibility, and a complete hardware implementation of the acoustic goniometer has been designed and field tested. The results are reported, and suggested areas for improvement and further exploration are discussed. PMID:27136563

  7. A Small Acoustic Goniometer for General Purpose Research.

    PubMed

    Pook, Michael L; Loo, Sin Ming

    2016-04-29

    Understanding acoustic events and monitoring their occurrence is a useful aspect of many research projects. In particular, acoustic goniometry allows researchers to determine the source of an event based solely on the sound it produces. The vast majority of acoustic goniometry research projects used custom hardware targeted to the specific application under test. Unfortunately, due to the wide range of sensing applications, a flexible general purpose hardware/firmware system does not exist for this purpose. This article focuses on the development of such a system which encourages the continued exploration of general purpose hardware/firmware and lowers barriers to research in projects requiring the use of acoustic goniometry. Simulations have been employed to verify system feasibility, and a complete hardware implementation of the acoustic goniometer has been designed and field tested. The results are reported, and suggested areas for improvement and further exploration are discussed.

  8. Informed consent to donate embryos for research purposes.

    PubMed

    Nelson, Erin; Mykitiuk, Roxanne; Nisker, Jeff

    2008-09-01

    To develop guidance for clinicians participating in the informed choice process with respect to the donation of human embryos for research purposes. 1. As indicated in the Canadian Institutes of Health Research Guidelines and the Assisted Human Reproduction Act, specific consent from both the gamete and embryo providers is required before embryos can be used for research purposes. The gamete donors may be different individuals than the embryo providers when donated gametes are used to create embryos. 2. The consent process should inform potential donors of the possible types of (and for final consent, the specific) research project(s) for which the embryos will be used; the risks involved in donating embryos to research, such as not having these embryos available for their reproductive purposes; the fact that the woman/couple will not benefit personally from donating embryos to research; the potential for commercial gain by others; the possibility that they will be contacted in future about the disposition of the embryos; the fact that confidentiality cannot be absolutely guaranteed. 3. Designation of cryopreserved embryos no longer be required for reproductive purposes to be donated to research, donated to another couple, or discarded should be discussed prior to gamete retrieval and made at the time of cryopreservation, with the understanding that in the future, final consent will be requested. The final decision as to the donation of cryopreserved embryos research should not be made until after the woman/ couple decide they no longer require the embryos for their reproductive purposes. The decision to end cryopreservation should be made separately from the decision regarding disposition of the embryos. The woman/couple will have to be re-contacted regarding the final disposition of their embryos. 4. As a result of lack of scientific data regarding the predictability of microscopic characterization of embryos and potential for pregnancy, it is recommended that

  9. Sampling in qualitative research. Purposeful and theoretical sampling; merging or clear boundaries?

    PubMed

    Coyne, I T

    1997-09-01

    Sampling is a very complex issue in qualitative research as there are many variations of qualitative sampling described in the literature and much confusion and overlapping of types of sampling, particularly in the case of purposeful and theoretical sampling. The terms purposeful and theoretical are viewed synonomously and used interchangeably in the literature. Many of the most frequent misinterpretations relate to the disparate meanings and usage of the terminology. It is important that the terminology is examined so that underlying assumptions be made more explicit. Lack of shared meanings and terminology in the nursing discourse creates confusion for the neophyte researcher and increases the production of studies with weak methodologies. This paper analyses critically purposeful and theoretical sampling and offers clarification on the use of theoretical sampling for nursing research. The aim is not to make prescriptive statements on sampling; rather, to enhance understanding of the differences between purposeful and theoretical sampling for nursing research.

  10. Small Multi-Purpose Research Facility (SMiRF)

    NASA Image and Video Library

    2015-10-15

    NASA Glenn engineer Monica Guzik in the Small Multi-Purpose Research Facility (SMiRF). The facility provides the ability to simulate the environmental conditions encountered in space for a variety of cryogenic applications such as thermal protection systems, fluid transfer operations and propellant level gauging. SMiRF is a low-cost, small-scale screening facility for concept and component testing of a wide variety of hardware and is capable of testing cryogenic hydrogen, oxygen, methane and nitrogen.

  11. Optimal Design and Purposeful Sampling: Complementary Methodologies for Implementation Research.

    PubMed

    Duan, Naihua; Bhaumik, Dulal K; Palinkas, Lawrence A; Hoagwood, Kimberly

    2015-09-01

    Optimal design has been an under-utilized methodology. However, it has significant real-world applications, particularly in mixed methods implementation research. We review the concept and demonstrate how it can be used to assess the sensitivity of design decisions and balance competing needs. For observational studies, this methodology enables selection of the most informative study units. For experimental studies, it entails selecting and assigning study units to intervention conditions in the most informative manner. We blend optimal design methods with purposeful sampling to show how these two concepts balance competing needs when there are multiple study aims, a common situation in implementation research.

  12. Optimal Design and Purposeful Sampling: Complementary Methodologies for Implementation Research

    PubMed Central

    Duan, Naihua; Bhaumik, Dulal K.; Palinkas, Lawrence A.; Hoagwood, Kimberly

    2015-01-01

    Optimal design has been an under-utilized methodology. However, it has significant real-world applications, particularly in mixed methods implementation research. We review the concept and demonstrate how it can be used to assess the sensitivity of design decisions and balance competing needs. For observational studies, this methodology enables selection of the most informative study units. For experimental studies, it entails selecting and assigning study units to intervention conditions in the most informative manner. We blend optimal design methods with purposeful sampling to show how these two concepts balance competing needs when there are multiple study aims, a common situation in implementation research. PMID:25491200

  13. Medical education: a particularly complex intervention to research.

    PubMed

    Mattick, Karen; Barnes, Rebecca; Dieppe, Paul

    2013-10-01

    Previous debate has explored whether medical education research should become more like health services research in terms of frameworks, collaborations and methodologies. Notable recent changes in health services research include an increasing emphasis on complex interventions, defined as interventions that involve more than one component. The purpose of this study was to explore the extent of thinking about medical education as a complex intervention and to analyse medical education research to determine whether its collaborations and methodologies are becoming more like health services research. Research articles published in three journals over 2 years were analysed to determine the purpose of the research in relation to a framework for evaluating complex interventions, the degree of collaboration, and the methodology. Most studies aimed to develop theory or assess effectiveness and many categories of the complex interventions framework were not represented in the medical education research literature. Studies usually involved only one research site and were predominantly quantitative but not experimental or quasi-experimental. Whilst medical education research has not moved significantly in the direction of health services research over recent years, the complex interventions lens provided insights into why this might be so (namely the significant challenges associated with researching medical education). We recommend that medical education researchers work within a complex interventions framework and look to research fields with similar challenges (e.g. the study of chronic illness in a changing context) for ideas about theories, frameworks, methodologies and collaborations that can illuminate the field of medical education research.

  14. Action Research and Organisational Learning: A Norwegian Approach to Doing Action Research in Complex Organisations

    ERIC Educational Resources Information Center

    Eikeland, Olav

    2012-01-01

    The purpose of this article is to present a specific approach to the practice of action research "in complex organisations". Clearly, there are many approaches to the challenge of doing action research in organisations; approaches that are, and also must be, quite context dependent and specific. But my purpose is neither to give an…

  15. Action Research and Organisational Learning: A Norwegian Approach to Doing Action Research in Complex Organisations

    ERIC Educational Resources Information Center

    Eikeland, Olav

    2012-01-01

    The purpose of this article is to present a specific approach to the practice of action research "in complex organisations". Clearly, there are many approaches to the challenge of doing action research in organisations; approaches that are, and also must be, quite context dependent and specific. But my purpose is neither to give an…

  16. Software architecture for a multi-purpose real-time control unit for research purposes

    NASA Astrophysics Data System (ADS)

    Epple, S.; Jung, R.; Jalba, K.; Nasui, V.

    2017-05-01

    A new, freely programmable, scalable control system for academic research purposes was developed. The intention was, to have a control unit capable of handling multiple PT1000 temperature sensors at reasonable accuracy and temperature range, as well as digital input signals and providing powerful output signals. To take full advantage of the system, control-loops are run in real time. The whole eight bit system with very limited memory runs independently of a personal computer. The two on board RS232 connectors allow to connect further units or to connect other equipment, as required in real time. This paper describes the software architecture for the third prototype that now provides stable measurements and an improvement in accuracy compared to the previous designs. As test case a thermal solar system to produce hot tap water and assist heating in a single-family house was implemented. The solar fluid pump was power-controlled and several temperatures at different points in the hydraulic system were measured and used in the control algorithms. The software architecture proved suitable to test several different control strategies and their corresponding algorithms for the thermal solar system.

  17. Flow characteristics of Korea multi-purpose research reactor

    SciTech Connect

    Heonil Kim; Hee Taek Chae; Byung Jin Jun; Ji Bok Lee

    1995-09-01

    The construction of Korea Multi-purpose Research Reactor (KMRR), a 30 MW{sub th} open-tank-in-pool type, is completed. Various thermal-hydraulic experiments have been conducted to verify the design characteristics of the KMRR. This paper describes the commissioning experiments to determine the flow distribution of KMRR core and the flow characteristics inside the chimney which stands on top of the core. The core flow is distributed to within {+-}6% of the average values, which is sufficiently flat in the sense that the design velocity in the fueled region is satisfied. The role of core bypass flow to confine the activated core coolant in the chimney structure is confirmed.

  18. Scoping review of complexity theory in health services research.

    PubMed

    Thompson, David S; Fazio, Xavier; Kustra, Erika; Patrick, Linda; Stanley, Darren

    2016-03-12

    There are calls for better application of theory in health services research. Research exploring knowledge translation and interprofessional collaboration are two examples, and in both areas, complexity theory has been identified as potentially useful. However, how best to conceptualize and operationalize complexity theory in health services research is uncertain. The purpose of this scoping review was to explore how complexity theory has been incorporated in health services research focused on allied health, medicine, and nursing in order to offer guidance for future application. Given the extensiveness of how complexity theory could be conceptualized and ultimately operationalized within health services research, a scoping review of complexity theory in health services research is warranted. A scoping review of published research in English was conducted using CINAHL, EMBASE, Medline, Cochrane, and Web of Science databases. We searched terms synonymous with complexity theory. We included 44 studies in this review: 27 were qualitative, 14 were quantitative, and 3 were mixed methods. Case study was the most common method. Long-term care was the most studied setting. The majority of research was exploratory and focused on relationships between health care workers. Authors most commonly used complexity theory as a conceptual framework for their study. Authors described complexity theory in their research in a variety of ways. The most common attributes of complexity theory used in health services research included relationships, self-organization, and diversity. A common theme across descriptions of complexity theory is that authors incorporate aspects of the theory related to how diverse relationships and communication between individuals in a system can influence change. Complexity theory is incorporated in many ways across a variety of research designs to explore a multitude of phenomena.. Although complexity theory shows promise in health services research

  19. Offering parents individualized feedback on the results of psychological testing conducted for research purposes with children: ethical issues and recommendations.

    PubMed

    Lefaivre, Marie-josée; Chambers, Christine T; Fernandez, Conrad V

    2007-01-01

    Research protocols involving children often include psychological testing as part of an assessment battery. Inclusion of such testing raises the question of whether parents (or others) should be offered the individualized results of their children's psychological testing conducted for research purposes. The purpose of this article is to provide a review of the ethical issues and principles associated with individualized feedback of psychological testing conducted for research purposes. Two hypothetical cases are offered to illustrate the complexities of this topic. Detailed recommendations for the management of disclosure of the results of psychological testing in research settings are also proposed.

  20. Human Research and Complexity Theory

    ERIC Educational Resources Information Center

    Horn, James

    2008-01-01

    The disavowal of positivist science by many educational researchers has resulted in a deepening polarization of research agendas and an epistemological divide that appears increasingly difficult to span. Despite a turning away from science altogether by some, and thus toward various forms of poststructuralist inquiry, this has not held back the…

  1. Human Research and Complexity Theory

    ERIC Educational Resources Information Center

    Horn, James

    2008-01-01

    The disavowal of positivist science by many educational researchers has resulted in a deepening polarization of research agendas and an epistemological divide that appears increasingly difficult to span. Despite a turning away from science altogether by some, and thus toward various forms of poststructuralist inquiry, this has not held back the…

  2. Action Research Networks: Role and Purpose in the Evaluation of Research Outcomes and Impacts

    ERIC Educational Resources Information Center

    Zornes, Deborah; Ferkins, Lesley; Piggot-Irvine, Eileen

    2016-01-01

    The focus of this paper is to share thinking about networks in action research (AR) and to consider their role, purpose, and how networks' outcomes and impacts might be evaluated. Networks are often a by-product of AR projects, yet research focused on the network itself as part of a project is rare. The paper is one of several associated with the…

  3. Action Research Networks: Role and Purpose in the Evaluation of Research Outcomes and Impacts

    ERIC Educational Resources Information Center

    Zornes, Deborah; Ferkins, Lesley; Piggot-Irvine, Eileen

    2016-01-01

    The focus of this paper is to share thinking about networks in action research (AR) and to consider their role, purpose, and how networks' outcomes and impacts might be evaluated. Networks are often a by-product of AR projects, yet research focused on the network itself as part of a project is rare. The paper is one of several associated with the…

  4. The Research Base in Languages for Specific Purposes.

    ERIC Educational Resources Information Center

    Grosse, Christine Uber

    More than 200 publications regarding Languages for Specific Purposes (LSP) from the past 25 years, excluding work on English for Specific Purposes, are compiled in this literature review. In introductory comments that precede the bibliography, it is noted that most of the activity in this field has occurred in the last decade, with eight…

  5. 40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection Research...

  6. 5 CFR 470.201 - Purposes of research programs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 470.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to... under this subpart are to stimulate and conduct personnel management research which: (a) Develops new...

  7. 5 CFR 470.201 - Purposes of research programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 470.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to... under this subpart are to stimulate and conduct personnel management research which: (a) Develops new...

  8. 5 CFR 470.201 - Purposes of research programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 470.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to... under this subpart are to stimulate and conduct personnel management research which: (a) Develops...

  9. 5 CFR 470.201 - Purposes of research programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 470.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to... under this subpart are to stimulate and conduct personnel management research which: (a) Develops...

  10. Researching the Film Audience: Purposes, Procedures, and Problems.

    ERIC Educational Resources Information Center

    Austin, Bruce A.

    Film audience research complements institutional research, verifying scholarship on the meanings films have to viewers and providing broad-based explanations of film images. Most important, such research focuses on the decision and motivation processes people use before they set foot in the movie theater, thereby helping to construct a context…

  11. Conclusion: Recommendations for How Practitioners, Researchers, and Policymakers Can Promote Youth Purpose

    ERIC Educational Resources Information Center

    Mariano, Jenni Menon

    2011-01-01

    Initially drawing from, yet then expanding on the research discussed in this volume, this article discusses specific measures that practitioners, researchers, and policymakers can take to support purpose among youth. Strategies for educators include utilizing practical purpose teaching tools, such as purpose interviews, purpose-related…

  12. Purposeful Action Research: Reconsidering Science and Technology Teacher Professional Development

    ERIC Educational Resources Information Center

    vanOostveen, Roland

    2017-01-01

    Initial plans for this project arose from a need to address issues of professional development of science and technology teachers that went beyond the norm available within school board settings. Two teams of 4 teachers responded to an invitation to participate in a collaborative action research project. Collaborative action research was chosen in…

  13. Subject Access to "Pornography" for Serious Research Purposes.

    ERIC Educational Resources Information Center

    Moya, Cynde

    2001-01-01

    Examines some of the research needs in academic disciplines for access to pornographic materials, and looks at tools, such as thesauri and Web directories, which have been built to help searchers find materials. Discusses research needs for access to materials; tools built by librarians to subject analyze material; and Internet words for indexing…

  14. 40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection...

  15. 40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection...

  16. 40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection...

  17. 40 CFR 18.3 - Purpose of Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Research Fellowships. 18.3 Section 18.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.3 Purpose of Environmental Protection Research Fellowships. Environmental Protection...

  18. Conclusion: Recommendations for how practitioners, researchers, and policymakers can promote youth purpose.

    PubMed

    Mariano, Jenni Menon

    2011-01-01

    Initially drawing from, yet then expanding on the research discussed in this volume, this article discusses specific measures that practitioners, researchers, and policymakers can take to support purpose among youth. Strategies for educators include utilizing practical purpose teaching tools, such as purpose interviews, purpose-related discussions, whole classroom and school community games, and purpose survey methodologies. Research strategies include expanding the study of youth purpose to more diverse groups of young people, and developing more succinct tools to assess purpose in research. Finally, the article discusses policy measures to promote purpose, including modification of current academic testing practices, expanding the breadth of course and extracurricular experiences in schools to provide opportunities for purpose development, and integrating purpose promotion skill-building into existing teacher education programs.

  19. Background, Purpose, and Scope of the GRE Board Research Program.

    ERIC Educational Resources Information Center

    Crawford, Bryce, Jr.

    The GRE Board established the Research Program to investigate ways to improve the GRE and its overall operation. Approximately 30 projects have been undertaken and funded by the GRE Board; perhaps a third of these have been completed. These projects can be divided into three groups: (1) those dealing with product or process or marketing…

  20. Strategic Implications of Cultural Analysis: Preserving Purpose through Market Research.

    ERIC Educational Resources Information Center

    Wiese, Michael D.

    1990-01-01

    This study investigated how cultural forces influence college choice at Olivet Nazarene University (Illinois), an institution seeking strategic guidance in light of the threat of contracting enrollment. The use of "local-cosmopolitan" dichotomy allowed researchers to determine an individual's pattern of social participation and…

  1. Purpose-driven biomaterials research in liver-tissue engineering.

    PubMed

    Ananthanarayanan, Abhishek; Narmada, Balakrishnan Chakrapani; Mo, Xuejun; McMillian, Michael; Yu, Hanry

    2011-03-01

    Bottom-up engineering of microscale tissue ("microtissue") constructs to recapitulate partially the complex structure-function relationships of liver parenchyma has been realized through the development of sophisticated biomaterial scaffolds, liver-cell sources, and in vitro culture techniques. With regard to in vivo applications, the long-lived stem/progenitor cell constructs can improve cell engraftment, whereas the short-lived, but highly functional hepatocyte constructs stimulate host liver regeneration. With regard to in vitro applications, microtissue constructs are being adapted or custom-engineered into cell-based assays for testing acute, chronic and idiosyncratic toxicities of drugs or pathogens. Systems-level methods and computational models that represent quantitative relationships between biomaterial scaffolds, cells and microtissue constructs will further enable their rational design for optimal integration into specific biomedical applications.

  2. Magnetospheric Exploration: Basic Research with a High Public Purpose

    NASA Astrophysics Data System (ADS)

    Baker, D. N.

    2012-12-01

    From the first in situ measurements of trapped radiation by J.A. Van Allen and coworkers with Explorer 1 to the latest modern satellite observations, magnetospheric research has been an exciting and compelling program of exploration. Evolving understanding of the Earth system and then the extension of this research to the magnetospheres of other planets such as Jupiter, Saturn, and Mercury has been a commingling of certain common themes as well as discovery of strikingly different properties from one system to the next. One key point is that much of the basic research performed concerning the near-Earth magnetospheric region also has profound societal relevance. The studies of magnetospheric properties - especially very high energy particles in the Van Allen belts - are absolutely central to space weather concerns that confront navigation, communications, remote sensing, and other operational human endeavors. It is a privilege as well as a challenge to continue to study magnetospheric problems that both illuminate remote astrophysical processes as well as affect our daily, technology-dependent lives.

  3. Exploitation of Botulinum Neurotoxins for Research and Clinical Purposes

    DTIC Science & Technology

    1993-06-01

    1985) For the protection of human subjects, the investicator~s) adhered to policies of applicable FederlLw4 CFR 46. ___ n conducting research uxci lzg...cmb.nnt’I hnolocy, the investigator(s) adhered to current gui.delines promulgated by tne National institutes of Health. Acce o Si n Date D-Nz TAb L U...induced bit ýkadc of ACh release from Aplysia neurons, when administered intra- neurorally . Investigations towards elucidating the molecular basis of the

  4. Safety management of complex research operations

    NASA Technical Reports Server (NTRS)

    Brown, W. J.

    1981-01-01

    Complex research and technology operations present many varied potential hazards which must be addressed in a disciplined independent safety review and approval process. The research and technology effort at the Lewis Research Center is divided into programmatic areas of aeronautics, space and energy. Potential hazards vary from high energy fuels to hydrocarbon fuels, high pressure systems to high voltage systems, toxic chemicals to radioactive materials and high speed rotating machinery to high powered lasers. A Safety Permit System presently covers about 600 potentially hazardous operations. The Safety Management Program described in this paper is believed to be a major factor in maintaining an excellent safety record at the Lewis Research Center.

  5. Purposeful Sampling for Qualitative Data Collection and Analysis in Mixed Method Implementation Research.

    PubMed

    Palinkas, Lawrence A; Horwitz, Sarah M; Green, Carla A; Wisdom, Jennifer P; Duan, Naihua; Hoagwood, Kimberly

    2015-09-01

    Purposeful sampling is widely used in qualitative research for the identification and selection of information-rich cases related to the phenomenon of interest. Although there are several different purposeful sampling strategies, criterion sampling appears to be used most commonly in implementation research. However, combining sampling strategies may be more appropriate to the aims of implementation research and more consistent with recent developments in quantitative methods. This paper reviews the principles and practice of purposeful sampling in implementation research, summarizes types and categories of purposeful sampling strategies and provides a set of recommendations for use of single strategy or multistage strategy designs, particularly for state implementation research.

  6. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research

    PubMed Central

    Palinkas, Lawrence A.; Horwitz, Sarah M.; Green, Carla A.; Wisdom, Jennifer P.; Duan, Naihua; Hoagwood, Kimberly

    2013-01-01

    Purposeful sampling is widely used in qualitative research for the identification and selection of information-rich cases related to the phenomenon of interest. Although there are several different purposeful sampling strategies, criterion sampling appears to be used most commonly in implementation research. However, combining sampling strategies may be more appropriate to the aims of implementation research and more consistent with recent developments in quantitative methods. This paper reviews the principles and practice of purposeful sampling in implementation research, summarizes types and categories of purposeful sampling strategies and provides a set of recommendations for use of single strategy or multistage strategy designs, particularly for state implementation research. PMID:24193818

  7. A commentary on domestic animals as dual-purpose models that benefit agricultural and biomedical research.

    PubMed

    Ireland, J J; Roberts, R M; Palmer, G H; Bauman, D E; Bazer, F W

    2008-10-01

    Research on domestic animals (cattle, swine, sheep, goats, poultry, horses, and aquatic species) at land grant institutions is integral to improving the global competitiveness of US animal agriculture and to resolving complex animal and human diseases. However, dwindling federal and state budgets, years of stagnant funding from USDA for the Competitive State Research, Education, and Extension Service National Research Initiative (CSREES-NRI) Competitive Grants Program, significant reductions in farm animal species and in numbers at land grant institutions, and declining enrollment for graduate studies in animal science are diminishing the resources necessary to conduct research on domestic species. Consequently, recruitment of scientists who use such models to conduct research relevant to animal agriculture and biomedicine at land grant institutions is in jeopardy. Concerned stakeholders have addressed this critical problem by conducting workshops, holding a series of meetings with USDA and National Institutes of Health (NIH) officials, and developing a white paper to propose solutions to obstacles impeding the use of domestic species as dual-purpose animal models for high-priority problems common to agriculture and biomedicine. In addition to shortfalls in research support and human resources, overwhelming use of mouse models in biomedicine, lack of advocacy from university administrators, long-standing cultural barriers between agriculture and human medicine, inadequate grantsmanship by animal scientists, and a scarcity of key reagents and resources are major roadblocks to progress. Solutions will require a large financial enhancement of USDA's Competitive Grants Program, educational programs geared toward explaining how research using agricultural animals benefits both animal agriculture and human health, and the development of a new mind-set in land grant institutions that fosters greater cooperation among basic and applied researchers. Recruitment of

  8. Complex Plasma Research Under Extreme Conditions

    SciTech Connect

    Ishihara, Osamu

    2008-09-07

    Complex plasma research under extreme conditions is described. The extreme conditions include low-dimensionality for self-organized structures of dust particles, dust magnetization in high magnetic field, criticality in phase transition, and cryogenic environment for Coulomb crystals and dust dynamics.

  9. [Recommendations on the ethical aspects of specimen collections and human biobanks for biomedical research purposes].

    PubMed

    Abascal Alonso, Moisés; de Abajo Iglesias, Francisco J; Campos Castelló, Jaime; Feito Grande, Lydia; Herrera Carranza, Joaquín; Júdez Gutiérrez, Javier; Martín Arribas, M Concepción; Martín, Uranga Amelia; Pàmpols Ros, Teresa; Sánchez Martínez, M José; Terracini, Benedetto

    2007-01-01

    The collecting and storing of human biospecimens and associated data are a historical fact in medicine, but the biobank is a very recent concept. The advent of new technologies making it possible to store all types of specimens, including cells capable of staying alive outside the human body for an indefinite length of time, and to obtain scientific data of all types, including genetic information, has opened up a whole new realm of possibilities for research. All of the above has led to complex ethical issues coming to fore concerning the specimen donors, the researchers handling the specimens and society as a whole. This document is aimed at providing some recommendations to serve as a guideline and encourage responsible deliberation among all those involved, thus contributing to society's recognition and trust in the forthrightness of the research and the solidary end purposes thereof. A total of nineteen recommendations have been drafted concerning the following aspects: Biobank organization and operation, degree of specimen identification, data management guarantees, consent for taking part in research and for the incorporation of specimens into the biobank, the right to know and the right not to know, consent for transferring specimens to third parties, specimen harvesting in deceased individuals, management of the pre-existing biospecimen collections, title to and commercialization of specimens and research findings and resulting payback benefiting the community.

  10. A Comparative Analysis of the Legal and Bioethical Frameworks Governing the Secondary Use of Data for Research Purposes.

    PubMed

    Tassé, Anne-Marie

    2016-06-01

    The secondary use of research and health data for purposes that differ from the original purpose of the collection is becoming a major trend in research, since it allows for the optimal use of already available resources, and reduces the costs of research activities. However, the consent provided at the time of the initial data collection might not have foreseen these new uses of the data. This is especially true for biobanks having collected data under a restricted or a disease-specific consent, and for data linkage, which allows researchers to combine research data with information from the medical record of participants. To protect the participants' privacy, confidentiality, and autonomy, the use of identifiable research and clinical data for secondary research purposes is governed by a rather complex legal and ethical framework. This article aims to: (1) provide a comprehensive analysis of the legal and bioethical framework governing the secondary use of data at the international level, and; (2) identify points of convergence and divergence with regard to the secondary use of data for research purposes, in five countries (Australia, Canada, France, United Kingdom, and United States). While the secondary use of already collected data carries benefits and drawbacks, the international and national legal framework provide guidance to promote a wider (although limited) secondary use of data, while protecting research participants' rights and interests. Despite some differences, the similarities between international and national regulations and norms reveal the emergence of a common set of criteria for the secondary use of data in international research.

  11. Building Consistency between Title, Problem Statement, Purpose, & Research Questions to Improve the Quality of Research Plans and Reports

    ERIC Educational Resources Information Center

    Newman, Isadore; Covrig, Duane M.

    2013-01-01

    Consistency in the title, problem, purpose, and research question improve the logic and transparency of research. When these components of research are aligned research design and planning are more coherent and research reports are more readable. This article reviews the process for checking for and improving consistency. Numerous examples of…

  12. Building Consistency between Title, Problem Statement, Purpose, & Research Questions to Improve the Quality of Research Plans and Reports

    ERIC Educational Resources Information Center

    Newman, Isadore; Covrig, Duane M.

    2013-01-01

    Consistency in the title, problem, purpose, and research question improve the logic and transparency of research. When these components of research are aligned research design and planning are more coherent and research reports are more readable. This article reviews the process for checking for and improving consistency. Numerous examples of…

  13. 9 CFR 314.9 - Specimens for educational, research, and other nonfood purposes; permits for, required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Specimens for educational, research, and other nonfood purposes; permits for, required. 314.9 Section 314.9 Animals and Animal Products... educational, research, and other nonfood purposes; permits for, required. (a) Specimens of condemned or other...

  14. 9 CFR 314.9 - Specimens for educational, research, and other nonfood purposes; permits for, required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Specimens for educational, research, and other nonfood purposes; permits for, required. 314.9 Section 314.9 Animals and Animal Products... educational, research, and other nonfood purposes; permits for, required. (a) Specimens of condemned or other...

  15. 9 CFR 314.9 - Specimens for educational, research, and other nonfood purposes; permits for, required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Specimens for educational, research, and other nonfood purposes; permits for, required. 314.9 Section 314.9 Animals and Animal Products... educational, research, and other nonfood purposes; permits for, required. (a) Specimens of condemned or other...

  16. Safety management of complex research operators

    NASA Technical Reports Server (NTRS)

    Brown, W. J.

    1981-01-01

    Complex research and technology operations present varied potential hazards which are addressed in a disciplined, independent safety review and approval process. Potential hazards vary from high energy fuels to hydrocarbon fuels, high pressure systems to high voltage systems, toxic chemicals to radioactive materials and high speed rotating machinery to high powered lasers. A Safety Permit System presently covers about 600 potentially hazardous operations. The Safety Management Program described is believed to be a major factor in maintaining an excellent safety record.

  17. Introducing video recording in primary care midwifery for research purposes: procedure, dataset, and use.

    PubMed

    Spelten, Evelien R; Martin, Linda; Gitsels, Janneke T; Pereboom, Monique T R; Hutton, Eileen K; van Dulmen, Sandra

    2015-01-01

    video recording studies have been found to be complex; however very few studies describe the actual introduction and enrolment of the study, the resulting dataset and its interpretation. In this paper we describe the introduction and the use of video recordings of health care provider (HCP)-client interactions in primary care midwifery for research purposes. We also report on the process of data management, data coding and the resulting data set. we describe our experience in undertaking a study using video recording to assess the interaction of the midwife and her client in the first antenatal consultation, in a real life clinical practice setting in the Netherlands. Midwives from six practices across the Netherlands were recruited to videotape 15-20 intakes. The introduction, complexity of the study and intrusiveness of the study were discussed within the research group. The number of valid recordings and missing recordings was measured; reasons not to participate, non-response analyses, and the inter-rater reliability of the coded videotapes were assessed. Video recordings were supplemented by questionnaires for midwives and clients. The Roter Interaction Analysis System (RIAS) was used for coding as well as an obstetric topics scale. at the introduction of the study, more initial hesitation in co-operation was found among the midwives than among their clients. The intrusive nature of the recording on the interaction was perceived to be minimal. The complex nature of the study affected recruitment and data collection. Combining the dataset with the questionnaires and medical records proved to be a challenge. The final dataset included videotapes of 20 midwives (7-23 recordings per midwife). Of the 460 eligible clients, 324 gave informed consent. The study resulted in a significant dataset of first antenatal consultations involving recording 269 clients and 194 partners. video recording of midwife-client interaction was both feasible and challenging and resulted

  18. Quantifying complexity in translational research: an integrated approach

    PubMed Central

    Munoz, David A.; Nembhard, Harriet Black; Kraschnewski, Jennifer L.

    2014-01-01

    Purpose This article quantifies complexity in translational research. The impact of major operational steps and technical requirements (TR) is calculated with respect to their ability to accelerate moving new discoveries into clinical practice. Design/Methodology/Approach A three-phase integrated Quality Function Deployment (QFD) and Analytic Hierarchy Process (AHP) method was used to quantify complexity in translational research. A case study in obesity was used to usability. Findings Generally, the evidence generated was valuable for understanding various components in translational research. Particularly, we found that collaboration networks, multidisciplinary team capacity and community engagement are crucial for translating new discoveries into practice. Research limitations/implications As the method is mainly based on subjective opinion, some argue that the results may be biased. However, a consistency ratio is calculated and used as a guide to subjectivity. Alternatively, a larger sample may be incorporated to reduce bias. Practical implications The integrated QFD-AHP framework provides evidence that could be helpful to generate agreement, develop guidelines, allocate resources wisely, identify benchmarks and enhance collaboration among similar projects. Originality/value Current conceptual models in translational research provide little or no clue to assess complexity. The proposed method aimed to fill this gap. Additionally, the literature review includes various features that have not been explored in translational research. PMID:25417380

  19. Understanding the Complexity of Teacher Reflection in Action Research

    ERIC Educational Resources Information Center

    Luttenberg, Johan; Meijer, Paulien; Oolbekkink-Marchand, Helma

    2017-01-01

    Reflection in action research is a complex matter, as is action research itself. In recent years, complexity science has regularly been called upon in order to more thoroughly understand the complexity of action research. The present article investigates the benefits that complexity science may yield for reflection in action research. This article…

  20. Understanding the Complexity of Teacher Reflection in Action Research

    ERIC Educational Resources Information Center

    Luttenberg, Johan; Meijer, Paulien; Oolbekkink-Marchand, Helma

    2017-01-01

    Reflection in action research is a complex matter, as is action research itself. In recent years, complexity science has regularly been called upon in order to more thoroughly understand the complexity of action research. The present article investigates the benefits that complexity science may yield for reflection in action research. This article…

  1. Quantifying complexity in translational research: an integrated approach.

    PubMed

    Munoz, David A; Nembhard, Harriet Black; Kraschnewski, Jennifer L

    2014-01-01

    The purpose of this paper is to quantify complexity in translational research. The impact of major operational steps and technical requirements is calculated with respect to their ability to accelerate moving new discoveries into clinical practice. A three-phase integrated quality function deployment (QFD) and analytic hierarchy process (AHP) method was used to quantify complexity in translational research. A case study in obesity was used to usability. Generally, the evidence generated was valuable for understanding various components in translational research. Particularly, the authors found that collaboration networks, multidisciplinary team capacity and community engagement are crucial for translating new discoveries into practice. As the method is mainly based on subjective opinion, some argue that the results may be biased. However, a consistency ratio is calculated and used as a guide to subjectivity. Alternatively, a larger sample may be incorporated to reduce bias. The integrated QFD-AHP framework provides evidence that could be helpful to generate agreement, develop guidelines, allocate resources wisely, identify benchmarks and enhance collaboration among similar projects. Current conceptual models in translational research provide little or no clue to assess complexity. The proposed method aimed to fill this gap. Additionally, the literature review includes various features that have not been explored in translational research.

  2. Fitness for purpose study of the Field Assessment Conditioning Tool (FACT): a research protocol.

    PubMed

    MacKinnon, Ralph James; Kennedy, Chris; Doherty, Catherine; Shepherd, Michael; Cole, Joanne; Stenfors-Hayes, Terese

    2015-04-13

    As part of a programme of research aiming to improve the outcomes of traumatically injured children, a multisource healthcare advocacy tool has been developed to allow trauma team members and hospital governance administrators to reflect and to act on complex trauma team-hospital systems interactions. We have termed this tool a Field Assessment Conditioning Tool (FACT). The FACT draws on quantitative data including clinical care points in addition to self-reflective qualitative data. The FACT is designed to provide feedback on this assessment data both horizontally across fellow potential team members and vertically to the hospital/organisation governance structure, enabling process gap identification and allowing an agenda of improvements to be realised. The aim of the study described in this paper is to explore the perceived fitness for purpose of the FACT to provide an opportunity for healthcare advocacy by healthcare professionals caring for traumatically injured children. The FACT will be implemented and studied in three district hospitals, each around a major trauma centre in the UK, USA and New Zealand. Using a qualitative approach with standardised semi-structured interviews and thematic analysis we will explore the following question: Is the FACT fit for purpose in terms of providing a framework to evaluate, reflect and act on the individual hospital's own performance (trauma team-hospital interactions) in terms of readiness to receive traumatically injured children? Ethics opinion was sought for each research host organisation participating and deemed not required. The results will be disseminated to participating sites, networks and published in high-impact journals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  3. Fitness for purpose study of the Field Assessment Conditioning Tool (FACT): a research protocol

    PubMed Central

    MacKinnon, Ralph James; Kennedy, Chris; Doherty, Catherine; Shepherd, Michael; Cole, Joanne; Stenfors-Hayes, Terese

    2015-01-01

    Introduction As part of a programme of research aiming to improve the outcomes of traumatically injured children, a multisource healthcare advocacy tool has been developed to allow trauma team members and hospital governance administrators to reflect and to act on complex trauma team-hospital systems interactions. We have termed this tool a Field Assessment Conditioning Tool (FACT). The FACT draws on quantitative data including clinical care points in addition to self-reflective qualitative data. The FACT is designed to provide feedback on this assessment data both horizontally across fellow potential team members and vertically to the hospital/organisation governance structure, enabling process gap identification and allowing an agenda of improvements to be realised. The aim of the study described in this paper is to explore the perceived fitness for purpose of the FACT to provide an opportunity for healthcare advocacy by healthcare professionals caring for traumatically injured children. Methods and analysis The FACT will be implemented and studied in three district hospitals, each around a major trauma centre in the UK, USA and New Zealand. Using a qualitative approach with standardised semi-structured interviews and thematic analysis we will explore the following question: Is the FACT fit for purpose in terms of providing a framework to evaluate, reflect and act on the individual hospital's own performance (trauma team—hospital interactions) in terms of readiness to receive traumatically injured children? Ethics and dissemination Ethics opinion was sought for each research host organisation participating and deemed not required. The results will be disseminated to participating sites, networks and published in high-impact journals. PMID:25869682

  4. Biospecimen Complexity-the Next Challenge for Cancer Research Biobanks?

    PubMed

    Watson, Peter H

    2017-02-15

    Purpose: Biospecimens (e.g., tissues, bloods, fluids) are critical for translational cancer research to generate the necessary knowledge to guide implementation of precision medicine. Rising demand and the need for higher quality biospecimens are already evident.Experimental Design: The recent increase in requirement for biospecimen complexity in terms of linked biospecimen types, multiple preservation formats, and longitudinal data was explored by assessing trends in cancer research publications from 2000 to 2014.Results: A PubMed search shows that there has been an increase in both raw numbers and the relative proportion (adjusted for total numbers of articles in each period) of the subgroups of articles typically associated with the use of biospecimens and both dense treatment and/or outcomes data and multiple biospecimen formats.Conclusions: Increasing biospecimen complexity is a largely unrecognized and new pressure on cancer research biobanks. New approaches to cancer biospecimen resources are needed such as the implementation of more efficient and dynamic consent mechanisms, stronger participant involvement in biobank governance, development of requirements for registration of collections, and models to establish stock targets for biobanks. In particular, the latter two approaches would enable funders to establish a better balance between biospecimen supply and research demand, reduce expenditure on duplicate collections, and encourage increased efficiency of biobanks to respond to the research need for more complex cases. This in turn would also enable biobanks to focus more on quality and standardization that are surely factors in the even more important arena of research reproducibility. Clin Cancer Res; 23(4); 894-8. ©2016 AACR. ©2016 American Association for Cancer Research.

  5. Some Thoughts on English for Research Publication Purposes (ERPP) and Related Issues

    ERIC Educational Resources Information Center

    Flowerdew, John

    2015-01-01

    Academic writing for research publication takes place around the globe, involving, according to a recent account, 5.5 million scholars, 2,000 publishers and 17,500 research/higher education institutions (Lillis & Curry 2010: 1). Because so many scholars whose first language is not English are now using English for publication purposes and…

  6. [Ethics guidelines for the creation and use of registries for biomedical research purposes].

    PubMed

    Abajo Iglesias, Francisco J de; Feito Grande, Lydia; Júdez Gutiérrez, Javier; Martín Arribas, M Concepción; Terracini, Benedetto; Pàmpols Ros, Teresa; Campos Castelló, Jaime; Martín Uranga, Amelia; Abascal Alonso, Moisés; Herrera Carranza, Joaquín; Sánchez Martínez, María José

    2008-01-01

    The clinical information stored in registries and records of different types is a fundamental tool for biomedical research. Up until just a few years ago, hardly any limitations existed on the creation and use of epidemiological registries or the use of information from pre-existing records for research purposes. This situation has changed substantially due mainly to the growing importance current laws place upon the safeguarding of the privacy and confidentiality of personal data. Although the legal framework is already quite explicit, a certain degree of leeway exists for ethical debate and prudence advice for the purpose of conducting valid, useful research with this information which will also respect the rights of the subjects and the laws in force. These guidelines deal with those aspects which have been considered relevant from an ethical standpoint in the handling of records and registries for research-related purposes, including not only the use but also the creation proper of the registries. A total of twenty-four recommendations are provided, grouped into ten sections: warranting of the creation of registry, organization and definition of responsibilities, scientific validity of the research project, ethical requirements of the collections of anonymous and anonymized data, ethical requirements of the registries including personal data, uses of medical records for research purposes, use of historical records of deceased individuals, contact with the research subjects, notification of results and review by a Research Ethics Committee.

  7. Some Thoughts on English for Research Publication Purposes (ERPP) and Related Issues

    ERIC Educational Resources Information Center

    Flowerdew, John

    2015-01-01

    Academic writing for research publication takes place around the globe, involving, according to a recent account, 5.5 million scholars, 2,000 publishers and 17,500 research/higher education institutions (Lillis & Curry 2010: 1). Because so many scholars whose first language is not English are now using English for publication purposes and…

  8. Doing Teacher Research: A Qualitative Analysis of Purposes, Processes and Experiences

    ERIC Educational Resources Information Center

    Gewirtz, Sharon; Shapiro, Jan; Maguire, Meg; Mahony, Pat; Cribb, Alan

    2009-01-01

    In this paper we draw upon 14 semi-structured interviews with the participants in a teacher-researcher project on the theme of "ensuring African Caribbean attainment" with the aim of shedding light on the purposes, processes and lived experiences of teacher research in a difficult and contentious intellectual and practical domain. After…

  9. Doing Teacher Research: A Qualitative Analysis of Purposes, Processes and Experiences

    ERIC Educational Resources Information Center

    Gewirtz, Sharon; Shapiro, Jan; Maguire, Meg; Mahony, Pat; Cribb, Alan

    2009-01-01

    In this paper we draw upon 14 semi-structured interviews with the participants in a teacher-researcher project on the theme of "ensuring African Caribbean attainment" with the aim of shedding light on the purposes, processes and lived experiences of teacher research in a difficult and contentious intellectual and practical domain. After…

  10. 9 CFR 314.9 - Specimens for educational, research, and other nonfood purposes; permits for, required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Specimens for educational, research... educational, research, and other nonfood purposes; permits for, required. (a) Specimens of condemned or other inedible materials, including embryos and specimens of animal parasites, may be released for...

  11. Validation of a Cost-Efficient Multi-Purpose SNP Panel for Disease Based Research

    PubMed Central

    Hou, Liping; Phillips, Christopher; Azaro, Marco; Brzustowicz, Linda M.; Bartlett, Christopher W.

    2011-01-01

    Background Here we present convergent methodologies using theoretical calculations, empirical assessment on in-house and publicly available datasets as well as in silico simulations, that validate a panel of SNPs for a variety of necessary tasks in human genetics disease research before resources are committed to larger-scale genotyping studies on those samples. While large-scale well-funded human genetic studies routinely have up to a million SNP genotypes, samples in a human genetics laboratory that are not yet part of such studies may be productively utilized in pilot projects or as part of targeted follow-up work though such smaller scale applications require at least some genome-wide genotype data for quality control purposes such as DNA “barcoding” to detect swaps or contamination issues, determining familial relationships between samples and correcting biases due to population effects such as population stratification in pilot studies. Principal Findings Empirical performance in classification of relative types for any two given DNA samples (e.g., full siblings, parental, etc) indicated that for outbred populations the panel performs sufficiently to classify relationship in extended families and therefore also for smaller structures such as trios and for twin zygosity testing. Additionally, familial relationships do not significantly diminish the (mean match) probability of sharing SNP genotypes in pedigrees, further indicating the uniqueness of the “barcode.” Simulation using these SNPs for an African American case-control disease association study demonstrated that population stratification, even in complex admixed samples, can be adequately corrected under a range of disease models using the SNP panel. Conclusion The panel has been validated for use in a variety of human disease genetics research tasks including sample barcoding, relationship verification, population substructure detection and statistical correction. Given the ease of genotyping

  12. Outlining Purposes, Stating the Nature of the Present Research, and Listing Research Questions or Hypotheses in Academic Papers

    ERIC Educational Resources Information Center

    Shehzad, Wasima

    2011-01-01

    Driving research questions from the prevailing issues and interests and developing from them new theories, formulas, algorithms, methods, and designs, and linking them to the interests of the larger audience is a vital component of scientific research papers. The present article discusses outlining purposes or stating the nature of the present…

  13. Outlining Purposes, Stating the Nature of the Present Research, and Listing Research Questions or Hypotheses in Academic Papers

    ERIC Educational Resources Information Center

    Shehzad, Wasima

    2011-01-01

    Driving research questions from the prevailing issues and interests and developing from them new theories, formulas, algorithms, methods, and designs, and linking them to the interests of the larger audience is a vital component of scientific research papers. The present article discusses outlining purposes or stating the nature of the present…

  14. Academics' Perceptions of the Purpose of Undergraduate Research Experiences in a Research-Intensive Degree

    ERIC Educational Resources Information Center

    Wilson, Anna; Howitt, Susan; Wilson, Kate; Roberts, Pam

    2012-01-01

    The inclusion of research experiences as core components of undergraduate curricula implies that students will be exposed to and situated within the research activities of their university. Such experiences thus provide a new prism through which to view the relations between teaching, research and learning. The intentions and actions of academics…

  15. Academics' Perceptions of the Purpose of Undergraduate Research Experiences in a Research-Intensive Degree

    ERIC Educational Resources Information Center

    Wilson, Anna; Howitt, Susan; Wilson, Kate; Roberts, Pam

    2012-01-01

    The inclusion of research experiences as core components of undergraduate curricula implies that students will be exposed to and situated within the research activities of their university. Such experiences thus provide a new prism through which to view the relations between teaching, research and learning. The intentions and actions of academics…

  16. The Intermediate Complexity Atmospheric Research Model

    NASA Astrophysics Data System (ADS)

    Gutmann, Ethan; Clark, Martyn; Rasmussen, Roy; Arnold, Jeffrey; Brekke, Levi

    2015-04-01

    The high-resolution, non-hydrostatic atmospheric models often used for dynamical downscaling are extremely computationally expensive, and, for a certain class of problems, their complexity hinders our ability to ask key scientific questions, particularly those related to hydrology and climate change. For changes in precipitation in particular, an atmospheric model grid spacing capable of resolving the structure of mountain ranges is of critical importance, yet such simulations can not currently be performed with an advanced regional climate model for long time periods, over large areas, and forced by many climate models. Here we present the newly developed Intermediate Complexity Atmospheric Research model (ICAR) capable of simulating critical atmospheric processes two to three orders of magnitude faster than a state of the art regional climate model. ICAR uses a simplified dynamical formulation based off of linear theory, combined with the circulation field from a low-resolution climate model. The resulting three-dimensional wind field is used to advect heat and moisture within the domain, while sub-grid physics (e.g. microphysics) are processed by standard and simplified physics schemes from the Weather Research and Forecasting (WRF) model. ICAR is tested in comparison to WRF by downscaling a climate change scenario over the Colorado Rockies. Both atmospheric models predict increases in precipitation across the domain with a greater increase on the western half. In contrast, statistically downscaled precipitation using multiple common statistical methods predict decreases in precipitation over the western half of the domain. Finally, we apply ICAR to multiple CMIP5 climate models and scenarios with multiple parameterization options to investigate the importance of uncertainty in sub-grid physics as compared to the uncertainty in the large scale climate scenario. ICAR is a useful tool for climate change and weather forecast downscaling, particularly for orographic

  17. 33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... Definition of Marine Debris for the Purposes of the Marine Debris Research, Prevention, and Reduction Act § 151.3000 Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

  18. 33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... Definition of Marine Debris for the Purposes of the Marine Debris Research, Prevention, and Reduction Act § 151.3000 Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

  19. 33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... Definition of Marine Debris for the Purposes of the Marine Debris Research, Prevention, and Reduction Act § 151.3000 Definition of marine debris for the purposes of the Marine Debris Research, Prevention,...

  20. 33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... Definition of Marine Debris for the Purposes of the Marine Debris Research, Prevention, and Reduction Act § 151.3000 Definition of marine debris for the purposes of the Marine Debris Research, Prevention,...

  1. Recruiting Gamblers from the General Population for Research Purposes: Outcomes from Two Contrasting Approaches

    ERIC Educational Resources Information Center

    Williams, Jeremy D.; Pulford, Justin; Bellringer, Maria; Abbott, Max

    2010-01-01

    Multiple means exist by which gamblers including problem gamblers may be recruited from the general population for research survey purposes. However, there appears to be limited discussion in the published literature about the relative merits of one or other approach. This paper addresses this gap, in part, by reporting the experiences of…

  2. Replication Research in Comparative Genre Analysis in English for Academic Purposes

    ERIC Educational Resources Information Center

    Basturkmen, Helen

    2014-01-01

    In recent years a number of comparative studies based on an established approach to genre analysis have been published in the English for Academic Purposes (EAP) literature. Studies in this emerging strand of research typically aim to identify how the rhetorical structure of a particular genre (a text type) or part of a genre may vary across…

  3. A General-Purpose Computer System for a Research and Development Center

    ERIC Educational Resources Information Center

    Fitzhugh, Robert J.; Glaser, Robert

    1975-01-01

    The evolution of a medium scale, general purpose, multi-language, time sharing computer system at the Learning Research and Development Center (LRDC) at the University of Pittsburgh is detailed. A strategy for the interfacing and control of laboratory devices is described with respect to several application environments; experimentation in the…

  4. 40 CFR 80.1656 - Exemptions for gasoline used for research, development, or testing purposes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Exemptions for gasoline used for... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur § 80.1656 Exemptions for gasoline used for research, development, or testing purposes. (a)...

  5. Recruiting Gamblers from the General Population for Research Purposes: Outcomes from Two Contrasting Approaches

    ERIC Educational Resources Information Center

    Williams, Jeremy D.; Pulford, Justin; Bellringer, Maria; Abbott, Max

    2010-01-01

    Multiple means exist by which gamblers including problem gamblers may be recruited from the general population for research survey purposes. However, there appears to be limited discussion in the published literature about the relative merits of one or other approach. This paper addresses this gap, in part, by reporting the experiences of…

  6. American Indian/Alaska Native willingness to provide biological samples for research purposes.

    PubMed

    Filippi, Melissa K; Young, Kristin L; Nazir, Niaman; Williams, Chandler; Brown, Travis; Choi, Won S; Greiner, K A; Daley, Christine M

    2012-06-01

    This article examines the willingness of American Indian/Alaska Natives (AI/AN) to provide biological samples for research purposes. Prior cases of abuse and misuse of individuals, materials, and data highlight ethical research concerns. Investigators may be hesitant to engage AI/ANs in research projects. We conducted a survey of AI/ANs in the central plains region of the US over 1 year. This convenience sample completed a series of questions on biological samples and research. Survey results (N=998) indicate that 70.15% of AI/ANs would be willing to provide saliva/spit for a specific study with the proper consent and control of samples. In conclusion, researchers should find ways to work with and for AI/ANs, assuring participant input in the research process.

  7. The complexities of nursing research with men.

    PubMed

    White, A; Johnson, M

    1998-01-01

    There has been a proliferation of nursing and other research on women's health over the last thirty years but a similar interest in men's health has not materialised. Within this paper we seek to explore the issues that need to be taken into consideration when conducting research with (or on) men. It outlines the current thinking on men and masculinity and the social development of stereotypes of men. The position of men with regard to the development of feminist thinking is also explored. The paper develops the argument by an examination of the different stages of the research process in nursing. The effect of gender on the setting of the research question; the choice of methodology; obtaining the data; analysis; discussion and dissemination of the findings of research conducted upon men are considered. We suggest that there is a requirement to consider the gender of both researched and researcher during the research process.

  8. Rigour and Complexity in Educational Research. Conducting Educational Research

    ERIC Educational Resources Information Center

    Berry, Kathleen; Kincheloe, Joe

    2004-01-01

    What does it mean to engage in rigorous research? What does a researcher need to know to produce such research? What is specifically involved in multiple method bricolage research? In an era where talk abounds about scientific rigour and evidence-based research in education, this groundbreaking book presents a new and compelling examination of…

  9. The Use of Facebook in Recruiting Participants for Health Research Purposes: A Systematic Review.

    PubMed

    Whitaker, Christopher; Stevelink, Sharon; Fear, Nicola

    2017-08-28

    Social media is a popular online tool that allows users to communicate and exchange information. It allows digital content such as pictures, videos and websites to be shared, discussed, republished and endorsed by its users, their friends and businesses. Adverts can be posted and promoted to specific target audiences by demographics such as region, age or gender. Recruiting for health research is complex with strict requirement criteria imposed on the participants. Traditional research recruitment relies on flyers, newspaper adverts, radio and television broadcasts, letters, emails, website listings, and word of mouth. These methods are potentially poor at recruiting hard to reach demographics, can be slow and expensive. Recruitment via social media, in particular Facebook, may be faster and cheaper. The aim of this study was to systematically review the literature regarding the current use and success of Facebook to recruit participants for health research purposes. A literature review was completed in March 2017 in the English language using MEDLINE, EMBASE, Web of Science, PubMed, PsycInfo, Google Scholar, and a hand search of article references. Papers from the past 12 years were included and number of participants, recruitment period, number of impressions, cost per click or participant, and conversion rate extracted. A total of 35 studies were identified from the United States (n=22), Australia (n=9), Canada (n=2), Japan (n=1), and Germany (n=1) and appraised using the Critical Appraisal Skills Programme (CASP) checklist. All focused on the feasibility of recruitment via Facebook, with some (n=10) also testing interventions, such as smoking cessation and depression reduction. Most recruited young age groups (16-24 years), with the remaining targeting specific demographics, for example, military veterans. Information from the 35 studies was analyzed with median values being 264 recruited participants, a 3-month recruitment period, 3.3 million impressions, cost

  10. Intelligent systems installed in building of research centre for research purposes

    NASA Astrophysics Data System (ADS)

    Matusov, Jozef; Mokry, Marian; Kolkova, Zuzana; Sedivy, Stefan

    2016-06-01

    The attractiveness of intelligent buildings is nowadays directly connected with higher level of comfort and also the economic mode of consumption energy for heating, cooling and the total consumption of electricity for electric devices. The technologies of intelligent buildings compared with conventional solutions allow dynamic optimization in real time and make it easy for operational message. The basic division of functionality in horizontal direction is possible divide in to two areas such as Economical sophisticated residential care about the comfort of people in the building and Security features. The paper deals with description of intelligent systems which has a building of Research Centre. The building has installed the latest technology for utilization of renewable energy and also latest systems of controlling and driving all devices which contribute for economy operation by achieving the highest thermal comfort and overall safety.

  11. 34 CFR 350.2 - What is the purpose of the Disability and Rehabilitation Research Project and Centers Program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... purpose of the Disability and Rehabilitation Research Project and Centers Program? The purpose of the... 34 Education 2 2014-07-01 2013-07-01 true What is the purpose of the Disability and Rehabilitation Research Project and Centers Program? 350.2 Section 350.2 Education Regulations of the Offices of the...

  12. 34 CFR 350.2 - What is the purpose of the Disability and Rehabilitation Research Project and Centers Program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... What is the purpose of the Disability and Rehabilitation Research Project and Centers Program? The purpose of the Disability and Rehabilitation Research Project and Centers Program is to plan and conduct... 34 Education 2 2013-07-01 2013-07-01 false What is the purpose of the Disability and...

  13. 34 CFR 350.2 - What is the purpose of the Disability and Rehabilitation Research Project and Centers Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... purpose of the Disability and Rehabilitation Research Project and Centers Program? The purpose of the... 34 Education 2 2011-07-01 2010-07-01 true What is the purpose of the Disability and Rehabilitation Research Project and Centers Program? 350.2 Section 350.2 Education Regulations of the Offices of the...

  14. 34 CFR 350.2 - What is the purpose of the Disability and Rehabilitation Research Project and Centers Program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... What is the purpose of the Disability and Rehabilitation Research Project and Centers Program? The purpose of the Disability and Rehabilitation Research Project and Centers Program is to plan and conduct... 34 Education 2 2012-07-01 2012-07-01 false What is the purpose of the Disability and...

  15. The Complexities of Conducting Ethnographic Race Research

    ERIC Educational Resources Information Center

    Klaas, Jongi

    2006-01-01

    This paper explores the challenges and dilemmas of conducting ethnographic race research in the context of the South African situation, forming part of my ethnographic race research PhD project, conducted in two historically white, single-sex schools in South Africa. First, it critically examines the theoretical dilemmas on crucial issues of…

  16. Complexity and Educational Research: A Critical Reflection

    ERIC Educational Resources Information Center

    Kuhn, Lesley

    2008-01-01

    Judgements concerning proper or appropriate educational endeavour, methods of investigation and philosophising about education necessarily implicate perspectives, values, assumptions and beliefs. In recent years ideas from the complexity sciences have been utilised in many domains including psychology, economics, architecture, social science and…

  17. Complexity and Truth in Educational Research

    ERIC Educational Resources Information Center

    Radford, Mike

    2008-01-01

    This paper considers the impact of complexity theory on the way in which we see propositions corresponding to the reality that they describe, and our concept of truth in that context. A contingently associated idea is the atomistic expectation that we can reduce language to primitive units of meaning, and tie those in with agreed units of…

  18. The history, purpose, and future of instruction in the responsible conduct of research.

    PubMed

    Steneck, Nicholas H; Bulger, Ruth Ellen

    2007-09-01

    This article discusses the key decisions and steps that have partially formalized instruction in the responsible conduct of research (RCR) in U.S. research institutions, the different purposes for offering and/or requiring such instruction, and suggestions for what needs to be done to enhance the professional development of researchers in the future. RCR education has developed during three distinct eras: the 1980s, when policy makers were most concerned with defining and investigating research misconduct; the 1990s, when there was significant but highly decentralized growth in RCR instruction; and the years since 2000, when there have been a series of reforms and educational developments. There is still a need for scientists, universities, and professional societies to develop consensus on best ethical practices in many areas of scientific research. More also needs to be learned about assessing the quality of RCR instruction and the effects of training on researchers' behavior. To help set the course for RCR instruction in the future, more effort and funding need to be directed to studying actual research behavior and the factors that influence it; RCR educators and administrators must develop a common vocabulary and framework for developing and evaluating the impact of RCR instruction; and research institutions and funding agencies alike need to take a more active role in promoting and supporting RCR instruction.

  19. Research in Complexity Theory and Combinatorial Algorithms

    DTIC Science & Technology

    1980-01-01

    other hand, when k = 1, the problem is obvious polynomial . Somewhere in between, there exists a boundary separating the two classes of problems. As to...input to an algorithm that solved the SHP), the complexity of the problem is not yet comipletely settled. For example, polynomial algorithms for solving...possible. B. Eberle [Ebe] discovered a polynomial time algorithm, O(!Vl4), that yields G with its radius upperbounded by I(r2 + r). .* L . - - T - I - ’U

  20. Complex Systems Thinking and Current Impasses in Health Disparities Research

    PubMed Central

    2011-01-01

    Complex systems approaches have received increasing attention in public health because reductionist approaches yield limited insights in the context of dynamic systems. Most discussions have been highly abstract. There is a need to consider the application of complex systems approaches to specific research questions. I review the features of population health problems for which complex systems approaches are most likely to yield new insights, and discuss possible applications of complex systems to health disparities research. I provide illustrative examples of how complex systems approaches may help address unanswered and persistent questions regarding genetic factors, life course processes, place effects, and the impact of upstream policies. The concepts and methods of complex systems may help researchers move beyond current impasse points in health disparities research. PMID:21778505

  1. Complexity, Methodology and Method: Crafting a Critical Process of Research

    ERIC Educational Resources Information Center

    Alhadeff-Jones, Michel

    2013-01-01

    This paper defines a theoretical framework aiming to support the actions and reflections of researchers looking for a "method" in order to critically conceive the complexity of a scientific process of research. First, it starts with a brief overview of the core assumptions framing Morin's "paradigm of complexity" and Le…

  2. Visual Complexity and Pictorial Memory: A Fifteen Year Research Perspective.

    ERIC Educational Resources Information Center

    Berry, Louis H.

    For 15 years an ongoing research project at the University of Pittsburgh has focused on the effects of variations in visual complexity and color on the storage and retrieval of visual information by learners. Research has shown that visual materials facilitate instruction, but has not fully delineated the interactions of visual complexity and…

  3. Action research to promote medical students' motivation in an English for Specific Purposes class.

    PubMed

    Dehnad, Afsaneh; Nasser, Hayedeh

    2014-01-01

    Action research is an attempt to seek immediate solutions to the problems experienced in educational settings. In this type of research, teachers are the researchers who intend to make instant reforms to develop, and improve their teaching styles and reflect on pedagogical practices. The purpose of this study was to conduct an action research to tackle the problem of students' low motivation in English classes at the medical school of Iran University of Medical Sciences in fall 2010. Participants of this study were 98 third-semester ESP students of medicine. To reform the situation and promote students' motivation to participate in classes more actively and eagerly, the researchers changed the syllabus by applying Kemmis and McTaggart's (1988) cyclical model of action research, and adopting task-based teaching. Data was collected by means of interviews with both teachers and students to determine the changes to be made in the syllabus, classroom observations to monitor students' behavioral changes, and a questionnaire to assess students' attitudes towards the changes. This research study had a number of valuable outcomes the most important of which was a change in classroom behavior of the students.

  4. Public attitudes in New Zealand towards the use of animals for research, testing and teaching purposes.

    PubMed

    Williams, V M; Dacre, I T; Elliott, M

    2007-04-01

    To investigate the awareness of and interest in the use of animals for research, testing and teaching (RTT) purposes, the levels of support and attitudes towards this use of animals, and the awareness of and opinions on regulations governing it within the public in New Zealand. An independent telephone survey was used to collect information including demographics, awareness and interest in the use of animals for RTT, attitudes towards the use of animals for RTT, and awareness of the regulation of the use of animals in RTT and the degree of confidence held in such regulation. Data were obtained from 750 respondents throughout New Zealand. The rim-weighting efficiency figure was 90%, indicating that the sample collected closely matched the population demographics for New Zealand. Overall, 33% of respondents expressed an interest in the issue generally, 39% were interested in the area of animals used for research and testing purposes, and 21% for teaching purposes. A majority of respondents agreed that the use of animals for teaching (72%) and research and testing (68%) purposes was acceptable as long as there was no unnecessary suffering by the animals. Respondents felt animal research was most justified for research into life-threatening and debilitating diseases, and least justified for safety-testing of cosmetics and household chemicals. Only 8% of respondents knew a fair amount (or more) about the legislation pertaining to the use of animals in RTT. The majority of New Zealanders were neither interested nor concerned about the use of animals in RTT. The largest proportion of respondents fell into a category of accepting this use of animals with conditions such as where there is no unnecessary suffering by the animals or where the research is for a serious disease. However, the responses also indicated that attitudes towards the use of animals in RTT as a general issue may change when that use is given a specific context. The understanding of public opinion with

  5. Developments in style and purpose of research on the learning of science

    NASA Astrophysics Data System (ADS)

    Gunstone, Richard F.; White, Richard T.; Fensham, Peter J.

    Recent years have seen a substantial growth in research that probes children's ideas about natural phenomena. This article places the research in a context that enables comprehension of how it informs and influences the practice of science education. To this end, past, present, and developing styles of research are discussed. The predominant style of past research was based on elaborate experimental designs and complex statistical analyses of data. Studies employing that style helped focus concern on questions about individual learning which the studies did not actually seek to answer, e.g., why does the learning resulting from a particular treatment vary between individuals? What is understanding and how can it be assessed? Such questions lie at the heart of current probing of children's ideas. Some issues of importance in the probing of children's ideas are considered, as are ways in which these issues have influenced the development of a current style of research. From this present context, developing styles in the research field are described. These focus particularly on research on the strategies used by learners, and on the continued growth of interaction between research and practice.

  6. Atmospheric performance of the special-purpose Solar Energy Research Institute (SERI) thin-airfoil family

    SciTech Connect

    Tangler, J; Smith, B; Jager, D; Olsen, T

    1990-09-01

    The Solar Energy Research Institute (SERI), in cooperation with SeaWest Energy Group, has completed extensive atmospheric testing of the special-purpose SERI thin-airfoil family during the 1990 wind season. The purpose of this test program was to experimentally verify the predicted performance characteristics of the thin-airfoil family on a geometrically optimized blade, and to compare it to original-equipment blades under atmospheric wind conditions. The tests were run on two identical Micon 65/13 horizontal-axis wind turbines installed side-by-side in a wind farm. The thin-airfoil family 7.96 m blades were installed on one turbine, and AeroStar 7.41 m blades were installed on the other. This paper presents final performance results of the side-by-side comparative field test for both clean and dirty blade conditions. 7 refs., 11 figs., 1 tab.

  7. Addressing Underrepresentation in Sex Work Research: Reflections on Designing a Purposeful Sampling Strategy.

    PubMed

    Bungay, Vicky; Oliffe, John; Atchison, Chris

    2016-06-01

    Men, transgender people, and those working in off-street locales have historically been underrepresented in sex work health research. Failure to include all sections of sex worker populations precludes comprehensive understandings about a range of population health issues, including potential variations in the manifestation of such issues within and between population subgroups, which in turn can impede the development of effective services and interventions. In this article, we describe our attempts to define, determine, and recruit a purposeful sample for a qualitative study examining the interrelationships between sex workers' health and the working conditions in the Vancouver off-street sex industry. Detailed is our application of ethnographic mapping approaches to generate information about population diversity and work settings within distinct geographical boundaries. Bearing in mind the challenges and the overwhelming discrimination sex workers experience, we scope recommendations for safe and effective purposeful sampling inclusive of sex workers' heterogeneity. © The Author(s) 2015.

  8. Action Research and the Challenge of Complexity

    ERIC Educational Resources Information Center

    Radford, Mike

    2007-01-01

    Contemporary models of action research that are complementary to and in some cases promoted in UK Government policy tend to follow a loosely scientific methodology. They are reductionist in character and work on the assumption that linear processes of balanced interaction between causes and effects enables the practitioner to make controlled…

  9. A portable shield for a neutron howitzer used for instructional and research purposes.

    PubMed

    Ali, S; Laherty, M; Laprade, J W; Cala, P M; Lipschultz, F P; Neuhauser, B

    2015-09-01

    Neutron howitzers are routinely used in universities to activate samples for instructional laboratory experiments on radioactivity. They are also a convenient source of neutrons and gammas for research purposes, but they must be used with caution. This paper describes the modeling, design, construction, and testing of a portable, economical shield for a 1.0 Curie neutron howitzer. The Monte Carlo N Particle Transport Code (MCNP5) has been used to model the (239)PuBe source and the howitzer and to design the external neutron and gamma shield.

  10. Semantic Support for Complex Ecosystem Research Environments

    NASA Astrophysics Data System (ADS)

    Klawonn, M.; McGuinness, D. L.; Pinheiro, P.; Santos, H. O.; Chastain, K.

    2015-12-01

    As ecosystems come under increasing stresses from diverse sources, there is growing interest in research efforts aimed at monitoring, modeling, and improving understanding of ecosystems and protection options. We aimed to provide a semantic infrastructure capable of representing data initially related to one large aquatic ecosystem research effort - the Jefferson project at Lake George. This effort includes significant historical observational data, extensive sensor-based monitoring data, experimental data, as well as model and simulation data covering topics including lake circulation, watershed runoff, lake biome food webs, etc. The initial measurement representation has been centered on monitoring data and related provenance. We developed a human-aware sensor network ontology (HASNetO) that leverages existing ontologies (PROV-O, OBOE, VSTO*) in support of measurement annotations. We explicitly support the human-aware aspects of human sensor deployment and collection activity to help capture key provenance that often is lacking. Our foundational ontology has since been generalized into a family of ontologies and used to create our human-aware data collection infrastructure that now supports the integration of measurement data along with simulation data. Interestingly, we have also utilized the same infrastructure to work with partners who have some more specific needs for specifying the environmental conditions where measurements occur, for example, knowing that an air temperature is not an external air temperature, but of the air temperature when windows are shut and curtains are open. We have also leveraged the same infrastructure to work with partners more interested in modeling smart cities with data feeds more related to people, mobility, environment, and living. We will introduce our human-aware data collection infrastructure, and demonstrate how it uses HASNetO and its supporting SOLR-based search platform to support data integration and semantic browsing

  11. Gold Complexes for Therapeutic Purposes: an Updated Patent Review (2010-2015).

    PubMed

    Nardon, Chiara; Pettenuzzo, Nicolò; Fregona, Dolores

    2016-01-01

    Gold has always aroused great interest in the history of mankind. It has been used for thousands of years for jewelry, religious cult valuables, durable goods and in the art world. However, few know that such a precious and noble metal was exploited in the past by the ancients also for its therapeutic properties. More recently, in the twentieth century some complexes containing gold centers in the oxidation state +1 were studied for the treatment of the rheumatoid arthritis and the orally-administered drug Auranofin was approved by the FDA in 1985. From the chemical point of view, gold derivatives deserve special attention due to the unique position of this metal within the periodic table, which results in unconventional relativistic effects and, ultimately, in the highest electronegativity, electron affinity and redox potential among all metals. In this review, after an introduction concerning the use of gold complexes in medicine, we have examined all the patents internationally or nationally published in the years 2010-2015 (until December 31, 2015) and describing new inorganic compounds containing gold(I) and gold(III) with proved therapeutic properties. These patents were filed to mainly protect compounds with promising anticancer and anti-inflammatory activities (total 18 and 4, respectively). In particular, this work explores both coordination compounds containing ligands with various donor atoms (e.g., N-, O-, S- and -P) and organo-gold derivatives with at least one Au-C bond. The toxicological profile and the intracellular targets reported for some among the patented gold derivatives are discussed.

  12. Medical Education: A Particularly Complex Intervention to Research

    ERIC Educational Resources Information Center

    Mattick, Karen; Barnes, Rebecca; Dieppe, Paul

    2013-01-01

    Previous debate has explored whether medical education research should become more like health services research in terms of frameworks, collaborations and methodologies. Notable recent changes in health services research include an increasing emphasis on complex interventions, defined as interventions that involve more than one component. The…

  13. Medical Education: A Particularly Complex Intervention to Research

    ERIC Educational Resources Information Center

    Mattick, Karen; Barnes, Rebecca; Dieppe, Paul

    2013-01-01

    Previous debate has explored whether medical education research should become more like health services research in terms of frameworks, collaborations and methodologies. Notable recent changes in health services research include an increasing emphasis on complex interventions, defined as interventions that involve more than one component. The…

  14. A green-emitting Cu complex for oxygen-sensing purpose: Synthesis, characterization and photophysical features

    NASA Astrophysics Data System (ADS)

    Hui, Han; Wei, Li; Zhentao, Liu; Xiangen, Han

    2015-05-01

    In the present work, a green-emitting Cu(I) complex [Cu(BT-Et)(POP)]BF4 was synthesized and fully characterized, where BT-Et = 4-(1-ethyl-1H-benzo[d]imidazol-2-yl)thiazole, POP = bis(2-(diphenylphosphanyl)phenyl) ether, respectively. An ethyl group was connected onto the diamine ligand to breach π-π attraction within solid [Cu(BT-Et)(POP)]BF4, favoring O2 molecule attack and sensitivity improvement. Its molecular identity was confirmed by single crystal analysis and theoretical calculation. [Cu(BT-Et)(POP)]BF4 emitted long-lived green emission peaking at 521 nm upon photoexcitation which was vulnerable towards O2 molecule, making itself a potential oxygen sensing material. [Cu(BT-Et)(POP)]BF4 was then doped into a silica supporting matrix MCM-41. The resulting composite samples showed sensing behavior towards O2 molecule, with short response time of 10 s and sensitivity of 5.56.

  15. Complexity and interdisciplinary approaches to environmental research

    NASA Astrophysics Data System (ADS)

    Kammen, Daniel M.

    2013-03-01

    The launch of volume 8 of Environmental Research Letters (ERL) comes at a critical time in terms of innovations and exciting areas of science, but particularly in the areas linking environmental research and action. The most recent climate change Conference of the Parties meeting (COP), in Doha in December 2012, has now come and gone. As has been dissected in the press, very little was accomplished. Some will see this as a failure, as I do, and others will reasonably enough note that this meeting, the 18th such COP was1 never intended to be a milestone moment. The current plan, in fact, is for a 'post-Kyoto' international climate agreement to be adopted only at the COP20 summit in December 2015. As we lead up to COP20, and potentially other regional or national approaches to climate protection, innovations in science, innovations in policy tools, and political commitment must come together. The science of climate change only continues to get clearer and clearer, and bleaker [1]. Later this year the IPCC will release its Fifth Assessment Report, AR5. The draft versions are out for review now. ERL has published a number of papers on climate change science, mitigation and adaptation, but one area where the world needs a particular focus is on the nexus of science and action. A summary of the Intergovernmental Panel on Climate Change's findings from the first assessment report (FAR; 1990) to the latest report is presented in figure 1. This graphic is specifically not about the scientific record alone. What is most important about this figure is the juxtaposition of the language of science and the language of ... language. Figure 1. Figure 1. A superposition of the state of climate science in three key data sets, and the dates of the first, second, third and fourth assessment reports (FAR, SAR, TAR, and AR4, respectively) plotted as vertical lines. On the right are the key statements from each of these reports, along with the conclusion of the Special Report on

  16. Offering Parents Individualized Feedback on the Results of Psychological Testing Conducted for Research Purposes with Children: Ethical Issues and Recommendations

    ERIC Educational Resources Information Center

    Lefaivre, Marie-josee; Chambers, Christine T.; Fernandez, Conrad V.

    2007-01-01

    Research protocols involving children often include psychological testing as part of an assessment battery. Inclusion of such testing raises the question of whether parents (or others) should be offered the individualized results of their children's psychological testing conducted for research purposes. The purpose of this article is to provide a…

  17. 33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... Definition of Marine Debris for the Purposes of the Marine Debris Research, Prevention, and Reduction Act...

  18. Research Methodology on Language Development from a Complex Systems Perspective

    ERIC Educational Resources Information Center

    Larsen-Freeman, Diane; Cameron, Lynne

    2008-01-01

    Changes to research methodology motivated by the adoption of a complexity theory perspective on language development are considered. The dynamic, nonlinear, and open nature of complex systems, together with their tendency toward self-organization and interaction across levels and timescales, requires changes in traditional views of the functions…

  19. Research Methodology on Language Development from a Complex Systems Perspective

    ERIC Educational Resources Information Center

    Larsen-Freeman, Diane; Cameron, Lynne

    2008-01-01

    Changes to research methodology motivated by the adoption of a complexity theory perspective on language development are considered. The dynamic, nonlinear, and open nature of complex systems, together with their tendency toward self-organization and interaction across levels and timescales, requires changes in traditional views of the functions…

  20. Rotorcraft research testing in the National Full-Scale Aerodynamics Complex at NASA Ames Research Center

    NASA Technical Reports Server (NTRS)

    Warmbrodt, W.; Smith, C. A.; Johnson, W.

    1985-01-01

    The unique capabilities of the National Full-Scale Aerodynamics Complex (NFAC) for testing rotorcraft systems are described. The test facilities include the 40- by 80-Foot Wind Tunnel, the 80- by 120-Foot Wind Tunnel, and the Outdoor Aerodynamic Research Facility. The Ames 7- by 10-Foot Subsonic Wind Tunnel is also used in support of the rotor research programs conducted in the NFAC. Detailed descriptions of each of the facilities, with an emphasis on helicopter rotor test capability, are presented. The special purpose rotor test equipment used in conducting helicopter research is reviewed. Test rigs to operate full-scale helicopter main rotors, helicopter tail rotors, and tilting prop-rotors are available, as well as full-scale and small-scale rotor systems for use in various research programs. The test procedures used in conducting rotor experiments are discussed together with representative data obtained from previous test programs. Specific examples are given for rotor performance, loads, acoustics, system interactions, dynamic and aeroelastic stability, and advanced technology and prototype demonstration models.

  1. Characterization of the general purpose research furnace for low-G directional solidification experiments

    NASA Technical Reports Server (NTRS)

    Crouch, R. K.; Fripp, A. L.; Debnam, W. J.; Clark, I. O.; Zweiner, J. W.; Carlson, F. M.

    1983-01-01

    Preliminary tests have shown that it is possible to control the temperature settings in NASA's General Purpose Research Furnace in such a manner as to obtain a constant rate of movement of a high temperature isotherm down the length of the furnace. These tests also showed that a temperature gradient on the order of 40 deg cm could be obtained in the furnace while moving the particular isotherm of interest, i.e., 900 C. This provides the possibility of performing directional solidification experiments in the furnace on a MEA flight in the low gravity environment provided by the Shuttle. A functional dependency of growth rate on perturbations during the the growth has been derived and shows the importance of avoiding non-steady growth rates and changing temperature gradients.

  2. Immortalized human hepatic cell lines for in vitro testing and research purposes

    PubMed Central

    Ramboer, Eva; Vanhaecke, Tamara; Rogiers, Vera; Vinken, Mathieu

    2015-01-01

    Summary The ubiquitous shortage of primary human hepatocytes has urged the scientific community to search for alternative cell sources, such as immortalized hepatic cell lines. Over the years, several human hepatic cell lines have been produced, whether or not using a combination of viral oncogenes and human telomerase reverse transcriptase protein. Conditional approaches for hepatocyte immortalization have also been established and allow generation of growth-controlled cell lines. A variety of immortalized human hepatocytes have already proven useful as tools for liver-based in vitro testing and fundamental research purposes. The present chapter describes currently applied immortalization strategies and provides an overview of the actually available immortalized human hepatic cell lines and their in vitro applications. PMID:26272134

  3. Classroom-Oriented Research from a Complex Systems Perspective

    ERIC Educational Resources Information Center

    Larsen-Freeman, Diane

    2016-01-01

    Bringing a complex systems perspective to bear on classroom-oriented research challenges researchers to think differently, seeing the classroom ecology as one dynamic system nested in a hierarchy of such systems at different levels of scale, all of which are spatially and temporally situated. This article begins with an introduction to complex…

  4. Challenging Images of Knowing: Complexity Science and Educational Research

    ERIC Educational Resources Information Center

    Davis, Brent; Sumara, Dennis J.

    2005-01-01

    This article represents an attempt to reconcile discussions of aspects of educational research with recent developments in complexity science. It is argued that current characterizations of and distinctions among research methodologies in education are potentially counterproductive, in large part because they tend to be defined against or in terms…

  5. The Pedagogy of Postgraduate Research Supervision and Its Complexities

    ERIC Educational Resources Information Center

    Lumadi, Mutendwahothe Walter

    2008-01-01

    This article attempts to clarify the role of supervisors in guiding postgraduate research students and the challenges and complexities encountered in the process of supervision. In the analysis and interpretation of data, it became evident that supervision of postgraduate research students varies enormously, depending on the subject area, the…

  6. Challenging Images of Knowing: Complexity Science and Educational Research

    ERIC Educational Resources Information Center

    Davis, Brent; Sumara, Dennis J.

    2005-01-01

    This article represents an attempt to reconcile discussions of aspects of educational research with recent developments in complexity science. It is argued that current characterizations of and distinctions among research methodologies in education are potentially counterproductive, in large part because they tend to be defined against or in terms…

  7. Considerations for conducting qualitative research with pediatric patients for the purpose of PRO development.

    PubMed

    Patel, Zabin S; Jensen, Sally E; Lai, Jin-Shei

    2016-09-01

    To provide an overview of methodological considerations when conducting qualitative research with pediatric patients for the purpose of patient-reported outcome measure development A literature review of qualitative methods in pediatric measure development was completed. Eight clinicians providing care to pediatric patients were interviewed for their expert input. Thematic analysis of the literature and clinician interviews was used to identify themes for consideration. Findings from the literature and expert interviews emphasized the way in which cognitive, linguistic, and social developmental factors affect pediatric patients' understanding of their condition and ability to communicate about their experiences in an interview. There was consensus among the experts that traditional semi-structured interviews with children younger than eight lack characteristics necessary to yield meaningful information about condition and symptom report because they may fail to capture children's understanding and awareness of their condition and may limit their ability to express themselves comfortably. Our findings include recommended strategies to optimize data collected in qualitative interviews with pediatric patients, including modifications to the interview process to establish rapport, construction of interview questions to ensure they are developmentally appropriate, and the use of supplementary techniques to facilitate communication. When employing qualitative methods in pediatric measure development, interview guides, methods, and length require careful tailoring to ensure the child's perspectives are captured. This may be best achieved through research performed with narrow age bands that employs flexibility in methods to allow children a comfortable way in which to communicate about their experiences.

  8. A Model Incorporating the Rationale and Purpose for Conducting Mixed-Methods Research in Special Education and beyond

    ERIC Educational Resources Information Center

    Collins, Kathleen M. T.; Onwuegbuzie, Anthony J.; Sutton, Ida L.

    2006-01-01

    This article provides a typology of reasons for conducting mixed-methods research in special education. The mixed-methods research process is described along with the role of the rationale and purpose of study. The reasons given in the literature for utilizing mixed-methods research are explicated, and the limitations of these reason frameworks…

  9. A Model Incorporating the Rationale and Purpose for Conducting Mixed-Methods Research in Special Education and beyond

    ERIC Educational Resources Information Center

    Collins, Kathleen M. T.; Onwuegbuzie, Anthony J.; Sutton, Ida L.

    2006-01-01

    This article provides a typology of reasons for conducting mixed-methods research in special education. The mixed-methods research process is described along with the role of the rationale and purpose of study. The reasons given in the literature for utilizing mixed-methods research are explicated, and the limitations of these reason frameworks…

  10. Factors that Affect Willingness to Donate Blood for the Purpose of Biospecimen Research in the Korean American Community

    PubMed Central

    Yen, Glorian P.; Davey, Adam

    2015-01-01

    Objective: Biorepositories have been key resources in examining genetically-linked diseases, particularly cancer. Asian Americans contribute to biorepositories at lower rates than other racial groups, but the reasons for this are unclear. We hypothesized that attitudes toward biospecimen research mediate the relationship between demographic and healthcare access factors, and willingness to donate blood for research purposes among individuals of Korean heritage. Methods: Descriptive statistics and bivariate analyses were utilized to characterize the sample with respect to demographic, psychosocial, and behavioral variables. Structural equation modeling with 5000 re-sample bootstrapping was used to assess each component of the proposed simple mediation models. Results: Attitudes towards biospecimen research fully mediate associations between age, income, number of years lived in the United States, and having a regular physician and willingness to donate blood for the purpose of research. Conclusion: Participants were willing to donate blood for the purpose of research despite having neutral feelings towards biospecimen research as a whole. Participants reported higher willingness to donate blood for research purposes when they were older, had lived in the United States longer, had higher income, and had a regular doctor that they visited. Many of the significant relationships between demographic and health care access factors, attitudes towards biospecimen research, and willingness to donate blood for the purpose of research may be explained by the extent of acculturation of the participants in the United States. PMID:25853387

  11. Complexity Thinking and Methodology: The Potential of "Complex Case Study" for Educational Research

    ERIC Educational Resources Information Center

    Hetherington, Lindsay

    2013-01-01

    Complexity theories have in common perspectives that challenge linear methodologies and views of causality. In educational research, relatively little has been written explicitly exploring their implications for educational research methodology in general and case study in particular. In this paper, I offer a rationale for case study as a research…

  12. A call to address complexity in prevention science research.

    PubMed

    Lich, Kristen Hassmiller; Ginexi, Elizabeth M; Osgood, Nathaniel D; Mabry, Patricia L

    2013-06-01

    The problems targeted by preventive interventions are often complex, embedded in multiple levels of social and environmental context, and span the developmental lifespan. Despite this appreciation for multiple levels and systems of influence, prevention science has yet to apply analytic approaches that can satisfactorily address the complexities with which it is faced. In this article, we introduce a systems science approach to problem solving and methods especially equipped to handle complex relationships and their evolution over time. Progress in prevention science may be significantly enhanced by applying approaches that can examine a wide array of complex systems interactions among biology, behavior, and environment that jointly yield unique combinations of developmental risk and protective factors and outcomes. To illustrate the potential utility of a systems science approach, we present examples of current prevention research challenges, and propose how to complement traditional methods and augment research objectives by applying systems science methodologies.

  13. FoCa: a modular treatment planning system for proton radiotherapy with research and educational purposes.

    PubMed

    Sánchez-Parcerisa, D; Kondrla, M; Shaindlin, A; Carabe, A

    2014-12-07

    FoCa is an in-house modular treatment planning system, developed entirely in MATLAB, which includes forward dose calculation of proton radiotherapy plans in both active and passive modalities as well as a generic optimization suite for inverse treatment planning. The software has a dual education and research purpose. From the educational point of view, it can be an invaluable teaching tool for educating medical physicists, showing the insights of a treatment planning system from a well-known and widely accessible software platform. From the research point of view, its current and potential uses range from the fast calculation of any physical, radiobiological or clinical quantity in a patient CT geometry, to the development of new treatment modalities not yet available in commercial treatment planning systems. The physical models in FoCa were compared with the commissioning data from our institution and show an excellent agreement in depth dose distributions and longitudinal and transversal fluence profiles for both passive scattering and active scanning modalities. 3D dose distributions in phantom and patient geometries were compared with a commercial treatment planning system, yielding a gamma-index pass rate of above 94% (using FoCa's most accurate algorithm) for all cases considered. Finally, the inverse treatment planning suite was used to produce the first prototype of intensity-modulated, passive-scattered proton therapy, using 13 passive scattering proton fields and multi-leaf modulation to produce a concave dose distribution on a cylindrical solid water phantom without any field-specific compensator.

  14. FoCa: a modular treatment planning system for proton radiotherapy with research and educational purposes

    NASA Astrophysics Data System (ADS)

    Sánchez-Parcerisa, D.; Kondrla, M.; Shaindlin, A.; Carabe, A.

    2014-12-01

    FoCa is an in-house modular treatment planning system, developed entirely in MATLAB, which includes forward dose calculation of proton radiotherapy plans in both active and passive modalities as well as a generic optimization suite for inverse treatment planning. The software has a dual education and research purpose. From the educational point of view, it can be an invaluable teaching tool for educating medical physicists, showing the insights of a treatment planning system from a well-known and widely accessible software platform. From the research point of view, its current and potential uses range from the fast calculation of any physical, radiobiological or clinical quantity in a patient CT geometry, to the development of new treatment modalities not yet available in commercial treatment planning systems. The physical models in FoCa were compared with the commissioning data from our institution and show an excellent agreement in depth dose distributions and longitudinal and transversal fluence profiles for both passive scattering and active scanning modalities. 3D dose distributions in phantom and patient geometries were compared with a commercial treatment planning system, yielding a gamma-index pass rate of above 94% (using FoCa’s most accurate algorithm) for all cases considered. Finally, the inverse treatment planning suite was used to produce the first prototype of intensity-modulated, passive-scattered proton therapy, using 13 passive scattering proton fields and multi-leaf modulation to produce a concave dose distribution on a cylindrical solid water phantom without any field-specific compensator.

  15. Recent Researches in Metal Supramolecular Complexes as Anticancer Agents.

    PubMed

    Zhou, Cheng-He; Zhang, Yi-Yi; Yan, Cong-Yan; Wan, Kun; Gan, Lin-Ling; Shi, Yuan

    2010-04-12

    The research and development of metal supramolecular complexes as anticancer supramolecular drugs, which are aggregates mainly formed by one or more inorganic metal compounds with one or more either inorganic or organic molecules in general via coordination bonds, has been a quite rapidly developing, increasingly active and newly rising highlight interdisciplinary field. Numerous efforts have been directed toward metal supramolecular complexes as potential anticancer agents and the unprecedented progress has been made. This has opened up a wholly new and infinite space to create novel metal-based bioactive supermolecules. More importantly, metal-based complex supermolecules as potential anticancer agents with wide potential applications have become highlight topics in recent years, and are becoming increasingly useful and important in preventing and treating cancer diseases. In view of the rapid progress in metal complex anticancer supermolecules with rich variation of structural types, this work systematically reviewed the recent research and development of the whole range of metal-based supramolecular complexes as anticancer agents mainly in 2009. The perspectives of the foreseeable future and potential application of metal supramolecular complexes in cancer therapy were also presented. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic metal supramolecular complex anticancer drugs.

  16. Recent researches in metal supramolecular complexes as anticancer agents.

    PubMed

    Zhou, Cheng-He; Zhang, Yi-Yi; Yan, Cong-Yan; Wan, Kun; Gan, Lin-Ling; Shi, Yuan

    2010-06-01

    The research and development of metal supramolecular complexes as anticancer supramolecular drugs, which are aggregates mainly formed by one or more inorganic metal compounds with one or more either inorganic or organic molecules in general via coordination bonds, has been a quite rapidly developing, increasingly active and newly rising highlight interdisciplinary field. Numerous efforts have been directed toward metal supramolecular complexes as potential anticancer agents and the unprecedented progress has been made. This has opened up a wholly new and infinite space to create novel metal-based bioactive supermolecules. More importantly, metal-based complex supermolecules as potential anticancer agents with wide potential applications have become highlight topics in recent years, and are becoming increasingly useful and important in preventing and treating cancer diseases. In view of the rapid progress in metal complex anticancer supermolecules with rich variation of structural types, this work systematically reviewed the recent research and development of the whole range of metal-based supramolecular complexes as anticancer agents mainly in 2009. The perspectives of the foreseeable future and potential application of metal supramolecular complexes in cancer therapy were also presented. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic metal supramolecular complex anticancer drugs.

  17. Real time capable control design with increased life expectancy for research purposes

    NASA Astrophysics Data System (ADS)

    Epple, S.; Jung, R.; Jalba, K.; Nasui, V.

    2017-05-01

    A new, freely programmable, scalable control system for academic research purposes was developed. The intention was, to have a control unit capable of handling multiple PT1000 temperature sensors at reasonable accuracy and temperature range, as well as digital input signals and providing more powerful output signals at 230V AC than conventional control units. To take full advantage of the system, control-loops are run in real time. The whole system runs independently of a personal computer. The two on-board RS232 connectors allow to connect further units to use more sensors or actuators or to connect other laboratory equipment, as required. To allow usage for long-time experiments, systematically electronic components with low failure-in-time (FIT) rate have been chosen in order to achieve high life expectancy. This paper describes the third prototype, which now provides stable measurements, and an improvement in accuracy compared to the previous designs. A rough estimation about the expected mean time between failures is given. As test case, a thermal solar system to produce hot tap water and assist heating in a single-family house was implemented. The solar fluid pump was power-controlled and several temperatures at different points in the hydraulic system were measured and used in the control algorithms. The hardware design proved suitable to test several different control strategies and their corresponding algorithms for the thermal solar system.

  18. MYRRHA a multi-purpose hybrid research reactor for high-tech applications

    SciTech Connect

    Abderrahim, H. A.; Baeten, P.

    2012-07-01

    MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is the flexible experimental accelerator driven system (ADS) in development at SCK-CEN. MYRRHA is able to work both in subcritical (ADS) as in critical mode. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material developments for generation IV (GEN IV) systems, material developments for fusion reactors, radioisotope production and industrial applications, such as Si-doping. MYRRHA will also demonstrate the ADS full concept by coupling the three components (accelerator, spallation target and subcritical reactor) at reasonable power level to allow operation feedback, scalable to an industrial demonstrator and allow the study of efficient transmutation of high-level nuclear waste. MYRRHA is based on the heavy liquid metal technology and so it will contribute to the development of lead fast reactor (LFR) technology and in critical mode, MYRRHA will play the role of European technology pilot plant in the roadmap for LFR. In this paper the historical evolution of MYRRHA and the rationale behind the design choices is presented and the latest configuration of the reactor core and primary system is described. (authors)

  19. Producing Snow Extent and Snow Water Equivalent Information for Climate Research Purposes - ESA DUE Globsnow Effort

    NASA Astrophysics Data System (ADS)

    Luojus, Kari; Pulliainen, Jouni; Rott, Helmut; Nagler, Thomas; Solberg, Rune; Wiesmann, Andreas; Derksen, Chris; Metsämäki, Sari; Malnes, Eirik; Bojkov, Bojan

    2010-05-01

    The European Space Agency (ESA) Data User Element (DUE) funded GlobSnow project aims at creating a global database of snow parameters for climate research purposes. The main objective is to create a long term dataset on two essential snow parameters. The project will provide information concerning the areal extent of snow (SE) on a global scale and snow water equivalent (SWE) for the Northern Hemisphere. Both products will include the end product derived from the satellite data along with accuracy information for each snow parameter. The temporal span of the SE product will be 15 years and the span for the SWE product will be 30 years. A key improvement of the snow products, when compared with the currently available data sets, will be the inclusion of a statistically derived accuracy estimate accompanying each SE or SWE estimate (on a pixel level). In addition to the SE and SWE time-series, an operational near-real time (NRT) snow information service will be implemented. The service will provide daily snow maps for hydrological, meteorological, and climate research purposes. The snow products will be based on data acquired from optical and passive microwave-based spaceborne sensors combined with ground-based weather station observations. The work was initiated in November 2008, and is being coordinated by the Finnish Meteorological Institute (FMI). Other project partners involved are NR (Norwegian Computing Centre), ENVEO IT GmbH, GAMMA Remote Sensing AG, Finnish Environment Institute (SYKE), Environment Canada (EC) and Northern Research Institute (Norut). Extensive algorithm evaluation efforts were carried out for the candidate SWE and SE algorithms during 2009 using ground truth data gathered from Canada, Scandinavia, Russia and the Alps. The acquired evaluation results have enabled the selection of the algorithms to be utilized for the GlobSnow SE and SWE products. The SWE product is derived using the FMI Algorithm and the SE product is a combination of NR and

  20. Purposeful Variable Selection and Stratification to Impute Missing FAST Data in Trauma Research

    PubMed Central

    Fuchs, Paul A.; del Junco, Deborah J.; Fox, Erin E.; Holcomb, John B.; Rahbar, Mohammad H.; Wade, Charles A.; Alarcon, Louis H.; Brasel, Karen J.; Bulger, Eileen M.; Cohen, Mitchell J.; Myers, John G.; Muskat, Peter; Phelan, Herb A.; Schreiber, Martin A.; Cotton, Bryan A.

    2013-01-01

    Background The Focused Assessment with Sonography for Trauma (FAST) exam is an important variable in many retrospective trauma studies. The purpose of this study was to devise an imputation method to overcome missing data for the FAST exam. Due to variability in patients’ injuries and trauma care, these data are unlikely to be missing completely at random (MCAR), raising concern for validity when analyses exclude patients with missing values. Methods Imputation was conducted under a less restrictive, more plausible missing at random (MAR) assumption. Patients with missing FAST exams had available data on alternate, clinically relevant elements that were strongly associated with FAST results in complete cases, especially when considered jointly. Subjects with missing data (32.7%) were divided into eight mutually exclusive groups based on selected variables that both described the injury and were associated with missing FAST values. Additional variables were selected within each group to classify missing FAST values as positive or negative, and correct FAST exam classification based on these variables was determined for patients with non-missing FAST values. Results Severe head/neck injury (odds ratio, OR=2.04), severe extremity injury (OR=4.03), severe abdominal injury (OR=1.94), no injury (OR=1.94), other abdominal injury (OR=0.47), other head/neck injury (OR=0.57) and other extremity injury (OR=0.45) groups had significant ORs for missing data; the other group odds ratio was not significant (OR=0.84). All 407 missing FAST values were imputed, with 109 classified as positive. Correct classification of non-missing FAST results using the alternate variables was 87.2%. Conclusions Purposeful imputation for missing FAST exams based on interactions among selected variables assessed by simple stratification may be a useful adjunct to sensitivity analysis in the evaluation of imputation strategies under different missing data mechanisms. This approach has the potential

  1. Intelligent mobility research for robotic locomotion in complex terrain

    NASA Astrophysics Data System (ADS)

    Trentini, Michael; Beckman, Blake; Digney, Bruce; Vincent, Isabelle; Ricard, Benoit

    2006-05-01

    The objective of the Autonomous Intelligent Systems Section of Defence R&D Canada - Suffield is best described by its mission statement, which is "to augment soldiers and combat systems by developing and demonstrating practical, cost effective, autonomous intelligent systems capable of completing military missions in complex operating environments." The mobility requirement for ground-based mobile systems operating in urban settings must increase significantly if robotic technology is to augment human efforts in these roles and environments. The intelligence required for autonomous systems to operate in complex environments demands advances in many fields of robotics. This has resulted in large bodies of research in areas of perception, world representation, and navigation, but the problem of locomotion in complex terrain has largely been ignored. In order to achieve its objective, the Autonomous Intelligent Systems Section is pursuing research that explores the use of intelligent mobility algorithms designed to improve robot mobility. Intelligent mobility uses sensing, control, and learning algorithms to extract measured variables from the world, control vehicle dynamics, and learn by experience. These algorithms seek to exploit available world representations of the environment and the inherent dexterity of the robot to allow the vehicle to interact with its surroundings and produce locomotion in complex terrain. The primary focus of the paper is to present the intelligent mobility research within the framework of the research methodology, plan and direction defined at Defence R&D Canada - Suffield. It discusses the progress and future direction of intelligent mobility research and presents the research tools, topics, and plans to address this critical research gap. This research will create effective intelligence to improve the mobility of ground-based mobile systems operating in urban settings to assist the Canadian Forces in their future urban operations.

  2. The JINR Tier1 Site Simulation for Research and Development Purposes

    NASA Astrophysics Data System (ADS)

    Korenkov, V.; Nechaevskiy, A.; Ososkov, G.; Pryahina, D.; Trofimov, V.; Uzhinskiy, A.; Voytishin, N.

    2016-02-01

    Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and executed only once. However big experiments last for years and decades, and the development of their computing system is going on, not only quantitatively but also qualitatively. Even with the substantial efforts invested in the design phase to understand the systems configuration, it would be hard enough to develop a system without additional research of its future evolution. The developers and operators face the problem of the system behaviour predicting after the planned modifications. A system for grid and cloud services simulation is developed at LIT (JINR, Dubna). This simulation system is focused on improving the effciency of the grid/cloud structures development by using the work quality indicators of some real system. The development of such kind of software is very important for making a new grid/cloud infrastructure for such big scientific experiments like the JINR Tier1 site for WLCG. The simulation of some processes of the Tier1 site is considered as an example of our application approach.

  3. Complex Systems and Educational Change: Towards a New Research Agenda

    ERIC Educational Resources Information Center

    Lemke, Jay L.; Sabelli, Nora H.

    2008-01-01

    How might we usefully apply concepts and procedures derived from the study of other complex dynamical systems to analyzing systemic change in education? In this article, we begin to define possible agendas for research toward developing systematic frameworks and shared terminology for such a project. We illustrate the plausibility of defining such…

  4. Change Management and Complexity: The Case for Narrative Action Research

    ERIC Educational Resources Information Center

    Boxelaar, Lucia; Paine, Mark; Beilin, Ruth

    2007-01-01

    Post-modern theorists have challenged the totalizing and unifying ambitions of change management practices. This paper explores how a narrative action research approach may be used to combine our modernist commitment to facilitate change and collaboration in the land management context with a post-modern sensitivity to complexity and difference.…

  5. Change Management and Complexity: The Case for Narrative Action Research

    ERIC Educational Resources Information Center

    Boxelaar, Lucia; Paine, Mark; Beilin, Ruth

    2007-01-01

    Post-modern theorists have challenged the totalizing and unifying ambitions of change management practices. This paper explores how a narrative action research approach may be used to combine our modernist commitment to facilitate change and collaboration in the land management context with a post-modern sensitivity to complexity and difference.…

  6. Complexity, Accuracy and Fluency: Definitions, Measurement and Research

    ERIC Educational Resources Information Center

    Housen, Alex; Kuiken, Folkert; Vedder, Ineke

    2012-01-01

    The theme of this volume, complexity, accuracy and fluency (CAF) as dimensions of second language production, proficiency and development, represents a thriving area of research that addresses two general questions that are at the heart of many studies in second language acquisition and applied linguistics: What makes a second language (L2)…

  7. Research on the complex network of the UNSPSC ontology

    NASA Astrophysics Data System (ADS)

    Xu, Yingying; Zou, Shengrong; Gu, Aihua; Wei, Li; Zhou, Ta

    The UNSPSC ontology mainly applies to the classification system of the e-business and governments buying the worldwide products and services, and supports the logic structure of classification of the products and services. In this paper, the related technologies of the complex network were applied to analyzing the structure of the ontology. The concept of the ontology was corresponding to the node of the complex network, and the relationship of the ontology concept was corresponding to the edge of the complex network. With existing methods of analysis and performance indicators in the complex network, analyzing the degree distribution and community of the ontology, and the research will help evaluate the concept of the ontology, classify the concept of the ontology and improve the efficiency of semantic matching.

  8. Research ethics in dissertations: ethical issues and complexity of reasoning.

    PubMed

    Kjellström, S; Ross, S N; Fridlund, B

    2010-07-01

    Conducting ethically sound research is a fundamental principle of scientific inquiry. Recent research has indicated that ethical concerns are insufficiently dealt with in dissertations. To examine which research ethical topics were addressed and how these were presented in terms of complexity of reasoning in Swedish nurses' dissertations. Analyses of ethical content and complexity of ethical reasoning were performed on 64 Swedish nurses' PhD dissertations dated 2007. A total of seven ethical topics were identified: ethical approval (94% of the dissertations), information and informed consent (86%), confidentiality (67%), ethical aspects of methods (61%), use of ethical principles and regulations (39%), rationale for the study (20%) and fair participant selection (14%). Four of those of topics were most frequently addressed: the majority of dissertations (72%) included 3-5 issues. While many ethical concerns, by their nature, involve systematic concepts or metasystematic principles, ethical reasoning scored predominantly at lesser levels of complexity: abstract (6% of the dissertations), formal (84%) and systematic (10%). Research ethics are inadequately covered in most dissertations by nurses in Sweden. Important ethical concerns are missing, and the complexity of reasoning on ethical principles, motives and implications is insufficient. This is partly due to traditions and norms that discount ethical concerns but is probably also a reflection of the ability of PhD students and supervisors to handle complexity in general. It is suggested that the importance of ethical considerations should be emphasised in graduate and post-graduate studies and that individuals with capacity to deal with systematic and metasystematic concepts are recruited to senior research positions.

  9. Complex critical realism: tenets and application in nursing research.

    PubMed

    Clark, Alexander M; Lissel, Sue L; Davis, Caroline

    2008-01-01

    To outline the main tenets of critical realism (CR), its use, and future application in nursing. Little work has been done to discuss how CR can be applied to nursing research. The tenets of CR include recognition of reality independent of human perceptions, a generative view of causation in open systems, and a focus on explanations and methodological eclecticism using a postdisciplinary approach. Critical realism is useful for (1) understanding complex outcomes, (2) optimizing interventions, and (3) researching biopsychosocial pathways. Such questions are central to evidence-based practice, chronic disease management, and population health. Critical realism is philosophically strong and potentially useful for nursing research.

  10. The Effect of Providing Research Purpose Information When Treatment Is Delayed.

    ERIC Educational Resources Information Center

    Dolly, John P.

    1978-01-01

    Finds that when subjects have a week to reflect on the research hypothesis, they will attempt to prove the hypothesis. Does not find, however, that increased information yields negative research results. (RL)

  11. Robotic Delivery of Complex Radiation Volumes for Small Animal Research

    PubMed Central

    Matinfar, Mohammad; Iordachita, Iulian; Wong, John; Kazanzides, Peter

    2011-01-01

    The Small Animal Radiation Research Platform (SARRP) is a novel and complete system capable of delivering multidirectional (focal), kilo-voltage radiation fields to targets in small animals under robotic control using cone-beam CT (CBCT) image guidance. The capability of the SARRP to deliver highly focused beams to multiple animal models provides new research opportunities that more realistically bridge laboratory research and clinical translation. This paper describes the design and operation of the SARRP for precise radiation delivery. Different delivery procedures are presented which enable the system to radiate through a series of points, representative of a complex shape. A particularly interesting case is shell dose irradiation, where the goal is to deliver a high dose of radiation to the shape surface, with minimal dose to the shape interior. The ability to deliver a dose shell allows mechanistic research of how a tumor interacts with its microenvironment to sustain its growth and lead to its resistance or recurrence. PMID:21643448

  12. The Mission and Purpose of TRUCEN (The Research University Civic Engagement Network)

    ERIC Educational Resources Information Center

    Journal of Higher Education Outreach and Engagement, 2012

    2012-01-01

    The mission of The Research University Civic Engagement Network (TRUCEN) is to advance civic engagement and engaged scholarship among research universities. TRUCEN has adopted the following goals for advancing civic engagement and engaged scholarship as part of the core mission of all research universities: (1) Encourage community-engaged…

  13. "The Purpose of This Study Is to": Connecting Lexical Bundles and Moves in Research Article Introductions

    ERIC Educational Resources Information Center

    Cortes, Viviana

    2013-01-01

    This article presents a group of lexical bundles identified in a corpus of research article introductions as the first step in the analysis of these expressions in the different sections of the research article. A one-million word corpus of research article introductions from various disciplines was compiled and the lexical bundles identified in…

  14. "The Purpose of This Study Is to": Connecting Lexical Bundles and Moves in Research Article Introductions

    ERIC Educational Resources Information Center

    Cortes, Viviana

    2013-01-01

    This article presents a group of lexical bundles identified in a corpus of research article introductions as the first step in the analysis of these expressions in the different sections of the research article. A one-million word corpus of research article introductions from various disciplines was compiled and the lexical bundles identified in…

  15. Developments in Style and Purpose of Research on the Learning of Science.

    ERIC Educational Resources Information Center

    Gunstone, Richard F.; And Others

    Recent years have seen a substantial growth in research that probes children's ideas about natural phenomena. This paper places that research in a context which enables comprehension of how it informs and influences the practice of science education. To this end, past, present, and future styles of research are considered to: (1) demonstrate links…

  16. Embedding research in health systems: lessons from complexity theory.

    PubMed

    Caffrey, Louise; Wolfe, Charles; McKevitt, Christopher

    2016-07-22

    Internationally, there has been increasing focus on creating health research systems. This article aims to investigate the challenges of implementing apparently simple strategies to support the development of a health research system. We focus on a case study of an English National Health Service Hospital Trust that sought to implement the national recommendation that health organisations should introduce a statement about research on all patient admission letters. We apply core concepts from complexity theory to the case study and undertake a documentary analysis of the email dialogue between staff involved in implementing this initiative. The process of implementing a research statement in patient admission letters in one clinical service took 1 year and 21 days. The length of time needed was influenced firstly by adaptive self-organisation, underpinned by competing interests. Secondly, it was influenced by the relationship between systems, rather than simply being a product of issues within those systems. The relationship between the health system and the research system was weaker than might have been expected. Responsibilities were unclear, leading to confusion and delayed action. Conventional ways of thinking about organisations suggest that change happens when leaders and managers change the strategic vision, structure or procedures in an organisation and then persuade others to rationally implement the strategy. However, health research systems are complex adaptive systems characterised by high levels of unpredictability due to self-organisation and systemic interactions, which give rise to 'emergent' properties. We argue for the need to study how micro-processes of organisational dynamics may give rise to macro patterns of behaviour and strategic organisational direction and for the use of systems approaches to investigate the emergent properties of health research systems.

  17. Transdisciplinary research for complex One Health issues: a scoping review of key concepts.

    PubMed

    Min, B; Allen-Scott, L K; Buntain, B

    2013-11-01

    In order to address the complexity inherent in researching One Health (OH) issues, we support the concept that researchers must transcend individual disciplinary and non-disciplinary boundaries, and move into the realm of transdisciplinary (TD) research approaches. For the purposes of this paper we use the term OH and the concept that OH research is conducted to solve complex health challenges at the animal-human--human-ecosystem interface. TD goes beyond interdisciplinary research to engages disciplines and communities through a unified conceptual framework. In this scoping review we investigated key concepts, definitions and themes in OH and TD based on the peer reviewed literature. We identified nine emerging themes in TD research: (1) education, (2) conflict amongst disciplines, (3) effective communication, (4) shared conceptual framework, (5) leadership, (6) perceived power differentials, (7) community-based methodologies, (8) support for TD research and (9) time and effort. This review provides a synthesized knowledge base that describes the nature, extent of evidence and challenges of engaging in TD initiatives. This knowledge base further provides a foundation for those interested in developing improved strategies for TD collaborative and cross-sectoral research in OH.

  18. Parallel Short Forms of the Crandall Social Desirability Test for Children: Shortening Instruments for Research Purposes.

    ERIC Educational Resources Information Center

    Carifio, James

    Researchers and program evaluators would often like to use a particular instrument, but do not because it is too long or would require too much testing time. Having a validated set of objective procedures for reducing the size of an instrument could improve many research and evaluation efforts. This paper reports the results of test reduction or…

  19. Educational Research: Educational Purposes, the Nature of Knowledge and Ethical Issues

    ERIC Educational Resources Information Center

    López-Alvarado, Julio

    2017-01-01

    Educational research should aim at improving educational practice by analysing the world of Education to understand it and make it better. It should be a critical, reflective and professionally oriented activity. Educational research should have three objectives: to explore issues and find answers to questions (for academics), to share policy…

  20. Does the Military Child Care System Serve Its Purpose? Research Brief

    ERIC Educational Resources Information Center

    Zellman, Gail L.; Gates, Susan M.; Cho, Michelle; Shaw Rebecca

    2008-01-01

    This research brief summarizes research suggesting that the U.S. Department of Defense may wish to consider expanding its child care benefits to cover more military families and a broader set of child care needs. [For "Options for Improving the Military Child Care System. Occasional Paper Summary", see ED502782. For the full paper, see ED502783.

  1. Research Article Introductions in English for Specific Purposes: A Comparison between Brazilian Portuguese and English

    ERIC Educational Resources Information Center

    Hirano, Eliana

    2009-01-01

    This paper compares the rhetorical organization of research article introductions in Brazilian Portuguese and in English within a subfield of Applied Linguistics. Using Swales' (1990) CARS model as an analytical tool, this exploratory study investigated 20 research articles. The findings indicate that introductions in Brazilian Portuguese tend to…

  2. Does the Military Child Care System Serve Its Purpose? Research Brief

    ERIC Educational Resources Information Center

    Zellman, Gail L.; Gates, Susan M.; Cho, Michelle; Shaw Rebecca

    2008-01-01

    This research brief summarizes research suggesting that the U.S. Department of Defense may wish to consider expanding its child care benefits to cover more military families and a broader set of child care needs. [For "Options for Improving the Military Child Care System. Occasional Paper Summary", see ED502782. For the full paper, see ED502783.

  3. The University-Academic Connection in Research: Corporate Purposes and Social Responsibilities.

    ERIC Educational Resources Information Center

    David, E. E., Jr.

    An increase in industry-supported academic research is economically and socially desirable. This refers not to industrial philanthropy but to research consistent with a commercial "mission." This increased coupling is advocated because there is fine science and technique created in academia which is not effectively coupled to the nation's…

  4. Research Article Introductions in English for Specific Purposes: A Comparison between Brazilian Portuguese and English

    ERIC Educational Resources Information Center

    Hirano, Eliana

    2009-01-01

    This paper compares the rhetorical organization of research article introductions in Brazilian Portuguese and in English within a subfield of Applied Linguistics. Using Swales' (1990) CARS model as an analytical tool, this exploratory study investigated 20 research articles. The findings indicate that introductions in Brazilian Portuguese tend to…

  5. The University-Academic Connection in Research: Corporate Purposes and Social Responsibilities.

    ERIC Educational Resources Information Center

    David, E. E., Jr.

    An increase in industry-supported academic research is economically and socially desirable. This refers not to industrial philanthropy but to research consistent with a commercial "mission." This increased coupling is advocated because there is fine science and technique created in academia which is not effectively coupled to the nation's…

  6. AR-601 anthropomorphic robot modeling and virtualization toolset for research and education purposes

    NASA Astrophysics Data System (ADS)

    Sirazetdinov, R.; Kamalov, A.; Nikitina, D.; Katsevman, E.

    2016-06-01

    A program toolset for modeling and visualization of anthropomorphic robot AR-601 produced by “NPO Androidnaya technika” was implemented, allowing one to test the components of the control system and to debug control algorithms on a virtual model of the robot. The toolset might be used for both scientific and educational purposes. The work is performed according to the Russian Government Program of Competitive Growth of the Kazan Federal University (KFU).

  7. From the Bronx to Bengifunda (and Other Lines of Flight): Deterritorializing Purposes and Methods in Science Education Research

    ERIC Educational Resources Information Center

    Gough, Noel

    2011-01-01

    In this essay I explore a number of questions about purposes and methods in science education research prompted by my reading of Wesley Pitts' ethnographic study of interactions among four students and their teacher in a chemistry classroom in the Bronx, New York City. I commence three "lines of flight" (small acts of Deleuzo-Guattarian…

  8. From the Bronx to Bengifunda (and Other Lines of Flight): Deterritorializing Purposes and Methods in Science Education Research

    ERIC Educational Resources Information Center

    Gough, Noel

    2011-01-01

    In this essay I explore a number of questions about purposes and methods in science education research prompted by my reading of Wesley Pitts' ethnographic study of interactions among four students and their teacher in a chemistry classroom in the Bronx, New York City. I commence three "lines of flight" (small acts of Deleuzo-Guattarian…

  9. 15 CFR 909.1 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 909.1 Section 909.1 Commerce and... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS MARINE DEBRIS § 909.1 Definition...

  10. 15 CFR 909.1 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 909.1 Section 909.1 Commerce and... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS MARINE DEBRIS § 909.1 Definition of...

  11. 15 CFR 909.1 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 909.1 Section 909.1 Commerce and... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS MARINE DEBRIS § 909.1 Definition of...

  12. 15 CFR 909.1 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 909.1 Section 909.1 Commerce and... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS MARINE DEBRIS § 909.1 Definition of...

  13. 15 CFR 909.1 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 909.1 Section 909.1 Commerce and... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS MARINE DEBRIS § 909.1 Definition of...

  14. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes E Appendix E to Part 197 National Defense Department of... THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. E Appendix E to Part...

  15. Fundamental Complex Plasma Research on Ground and under Microgravity Conditions

    NASA Astrophysics Data System (ADS)

    Thomas, Hubertus; Fortov, Vladimir; Thoma, Markus; Pustylnik, Mikhail; Lipaev, Andrey; Morfill, Gregor; Molotkov, Vladimir; Usachev, Alexander; Nosenko, Vladimir; Fink, Martin; Petrov, Oleg; Rubin-Zuzic, Milenko

    2016-07-01

    Complex (dusty) plasma is plasma containing small solid particles in the sub-mm range. Those "dust" particles are highly charged due to the collection of electrons and ions and they interact electrostatically. Depending on the charge, density, and kinetic temperature of the particles, the interaction may be strong leading to collective effects and the emergence of liquid or solid behavior. In that sense complex plasmas are perfect model systems for the investigation of fundamental processes in classical condensed matter physics since their constituent mesoscopic particles are individually observable and can be regarded as classically interacting "proxy atoms". The term "complex plasmas" is widely used in the literature to distinguish dusty plasmas composed of a weakly ionized gas and charged microparticles specially "designed" for investigations in classical condensed matter, from naturally occurring systems. Gravity influences the complex plasma, the microparticles sediment and stable systems can only be achieved through counteracting gravity with other volume forces, e.g. electric or thermophoretic force. This allows producing two-dimensional - monolayer - systems, or three-dimensional systems under stress. Only under weightlessness conditions, large and homogeneous 3D systems can be formed. Although phenomena in classical condensed matter physics are in the forefront of complex plasma research the basic know-how gained from experiments, theory and numerical simulations can be of importance for the understanding of naturally occurring dusty plasmas in space. Thus, in this presentation I will show recent work on complex plasmas from the ground and first results from the PK-4 facility onboard the International Space Station ISS. Acknowledgements: We would like to acknowledge the joint ESA-ROSCOSMOS Experiment «Plasma Kristall-4» onboard the International Space Station ISS. This work is partly supported by DLR grant 50WM1441/ 50WM1442 and by the Russian Science

  16. Liquid Methane Conditioning Capabilities Developed at the NASA Glenn Research Center's Small Multi- Purpose Research Facility (SMiRF) for Accelerated Lunar Surface Storage Thermal Testing

    NASA Technical Reports Server (NTRS)

    Bamberger, Helmut H.; Robinson, R. Craig; Jurns, John M.; Grasl, Steven J.

    2011-01-01

    Glenn Research Center s Creek Road Cryogenic Complex, Small Multi-Purpose Research Facility (SMiRF) recently completed validation / checkout testing of a new liquid methane delivery system and liquid methane (LCH4) conditioning system. Facility checkout validation was conducted in preparation for a series of passive thermal control technology tests planned at SMiRF in FY10 using a flight-like propellant tank at simulated thermal environments from 140 to 350K. These tests will validate models and provide high quality data to support consideration of LCH4/LO2 propellant combination option for a lunar or planetary ascent stage.An infrastructure has been put in place which will support testing of large amounts of liquid methane at SMiRF. Extensive modifications were made to the test facility s existing liquid hydrogen system for compatibility with liquid methane. Also, a new liquid methane fluid conditioning system will enable liquid methane to be quickly densified (sub-cooled below normal boiling point) and to be quickly reheated to saturation conditions between 92 and 140 K. Fluid temperatures can be quickly adjusted to compress the overall test duration. A detailed trade study was conducted to determine an appropriate technique to liquid conditioning with regard to the SMiRF facility s existing infrastructure. In addition, a completely new roadable dewar has been procured for transportation and temporary storage of liquid methane. A new spherical, flight-representative tank has also been fabricated for integration into the vacuum chamber at SMiRF. The addition of this system to SMiRF marks the first time a large-scale liquid methane propellant test capability has been realized at Glenn.This work supports the Cryogenic Fluid Management Project being conducted under the auspices of the Exploration Technology Development Program, providing focused cryogenic fluid management technology efforts to support NASA s future robotic or human exploration missions.

  17. Veterinary biobank facility: development and management for diagnostic and research purposes.

    PubMed

    Lombardo, Tina; Dotti, Silvia; Villa, Riccardo; Cinotti, Stefano; Ferrari, Maura

    2015-01-01

    Biobanking is an essential tool for ensuring easy availability of high-quality biomaterial collections that combine essential samples and epidemiological, clinical, and research data for the scientific community. Specimen collection is an integral part of clinical research. Indeed, every year throughout the world, millions of biological samples are stored for diagnostics and research, but in many fields the lack of biological material and models is a major hindrance for ongoing research. A biobank facility provides suitable samples for large-scale screening studies and database repositories. Software dedicated to biological banks simplify sample registration and identification, the cataloging of sample properties (type of sample/specimen, associated diseases and/or therapeutic protocols, environmental information, etc.), sample tracking, quality assurance, and specimen availability characterized by well-defined features. Biobank facilities must adopt good laboratory practices (GLPs) and a stringent quality control system and also comply with ethical issues, when required. The creation of a veterinary network can be useful under different aspects: the first one is related to the importance of animal sciences itself to improve research and strategies in the different branches of the veterinary area, and the second aspect is related to the possibility of data management harmonization to improve scientific cooperation.

  18. Troubleshooting Complex Equipment in the Military Services: Research and Prospects.

    DTIC Science & Technology

    1979-12-01

    Cmfnmm u, migde a wwesitIt OW6668Y 410d 1401011100 by’ 11. k M06bo) Troubleshooting of complex equipments in the military rmins a problem for many reasons...Services: Research and Prospects SECrtN I. IMM OUnCxI One of the first experiments on human troubleshooting of K electronic equip ent was conducted in...As another and more surprising example, if a set of K "links’ p of a monotone function are known, an equivalent network can be obtained by placing in

  19. The ESPAT tool: a general-purpose DSS shell for solving stochastic optimization problems in complex river-aquifer systems

    NASA Astrophysics Data System (ADS)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel; Tilmant, Amaury

    2015-04-01

    Stochastic programming methods are better suited to deal with the inherent uncertainty of inflow time series in water resource management. However, one of the most important hurdles in their use in practical implementations is the lack of generalized Decision Support System (DSS) shells, usually based on a deterministic approach. The purpose of this contribution is to present a general-purpose DSS shell, named Explicit Stochastic Programming Advanced Tool (ESPAT), able to build and solve stochastic programming problems for most water resource systems. It implements a hydro-economic approach, optimizing the total system benefits as the sum of the benefits obtained by each user. It has been coded using GAMS, and implements a Microsoft Excel interface with a GAMS-Excel link that allows the user to introduce the required data and recover the results. Therefore, no GAMS skills are required to run the program. The tool is divided into four modules according to its capabilities: 1) the ESPATR module, which performs stochastic optimization procedures in surface water systems using a Stochastic Dual Dynamic Programming (SDDP) approach; 2) the ESPAT_RA module, which optimizes coupled surface-groundwater systems using a modified SDDP approach; 3) the ESPAT_SDP module, capable of performing stochastic optimization procedures in small-size surface systems using a standard SDP approach; and 4) the ESPAT_DET module, which implements a deterministic programming procedure using non-linear programming, able to solve deterministic optimization problems in complex surface-groundwater river basins. The case study of the Mijares river basin (Spain) is used to illustrate the method. It consists in two reservoirs in series, one aquifer and four agricultural demand sites currently managed using historical (XIV century) rights, which give priority to the most traditional irrigation district over the XX century agricultural developments. Its size makes it possible to use either the SDP or

  20. Purposeful Design of Formal Laboratory Instruction as a Springboard to Research Participation

    ERIC Educational Resources Information Center

    Cartrette, David P.; Miller, Matthew L.

    2013-01-01

    An innovative first- and second-year laboratory course sequence is described. The goal of the instructional model is to introduce chemistry and biochemistry majors to the process of research participation earlier in their academic training. To achieve that goal, the instructional model incorporates significant hands-on experiences with chemical…

  1. Reporting Empirical Research on Adolescence: Reflections on the Appeal of Coherence, Purpose and Responsibility

    ERIC Educational Resources Information Center

    Levesque, Roger J. R.

    2006-01-01

    The study of adolescence has come of age. Many successful journals now provide researchers with a wide variety of reasonable options for contributing to our understanding of adolescents and their place in society. This article explores these options and offers suggestions to prospective authors, especially those who expect to publish in the…

  2. Unpacking a Liturgical Framing of Desire for the Purposes of Educational Research

    ERIC Educational Resources Information Center

    Renga, Ian Parker

    2017-01-01

    Much of the public discourse on education arguably reinforces the assumption that most stakeholders share the same desires for teaching and learning--desires reflecting a liberal paradigm that stresses individualism, control, and efficiency. But there are other desires, and additional empirical research informed by a Vygotskian sociocultural…

  3. Centre for Educational Research and iInnovation; Purpose, Programmes, Progress.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The Centre for Educational Research and Innovation (CERI) was established so that educational change in Organisation for Economic Co-Operation and Development (OECD) countries could be accomplished through a coherent, continuing process of development and experimentation. The main objectives for the Centre are to promote and support the…

  4. English for Research Purposes at the University of Santiago de Compostela: A Survey

    ERIC Educational Resources Information Center

    Fernandez Polo, Francisco Javier; Cal Varela, Mario

    2009-01-01

    Although much research has now accumulated on the dominance of English in world science, attention to the specific reality of Southern European countries has been comparatively scarce. This paper intends to partly redress this imbalance by reporting on survey data gathered at the University of Santiago de Compostela, Spain. Data were collected by…

  5. Murine animal models for preclinical islet transplantation: No model fits all (research purposes).

    PubMed

    Cantarelli, Elisa; Citro, Antonio; Marzorati, Simona; Melzi, Raffaella; Scavini, Marina; Piemonti, Lorenzo

    2013-01-01

    Advances in islet transplantation research have led to remarkable improvements in the outcome in humans with type 1 diabetes. However, pitfalls, mainly linked both to early liver-specific inflammatory events and to pre-existing and transplant-induced auto- and allo-specific adaptive immune responses, still remain. In this scenario research into pancreatic islet transplantation, essential to investigate new strategies to overcome open issues, needs very well-designed preclinical studies to obtain consistent and reliable results and select only promising strategies that may be translated into the clinical practice. This review discusses the main shortcomings of the mouse models currently used in islet transplantation research, outlining the main factors and variables to take into account for the design of new preclinical studies. Since several parameters concerning both the graft (i.e., islets) and the recipient (i.e., diabetic mice) may influence transplant outcome, we recommend considering several critical points in designing future bench-to-bedside islet transplantation research.

  6. Reporting Empirical Research on Adolescence: Reflections on the Appeal of Coherence, Purpose and Responsibility

    ERIC Educational Resources Information Center

    Levesque, Roger J. R.

    2006-01-01

    The study of adolescence has come of age. Many successful journals now provide researchers with a wide variety of reasonable options for contributing to our understanding of adolescents and their place in society. This article explores these options and offers suggestions to prospective authors, especially those who expect to publish in the…

  7. English for Research Purposes at the University of Santiago de Compostela: A Survey

    ERIC Educational Resources Information Center

    Fernandez Polo, Francisco Javier; Cal Varela, Mario

    2009-01-01

    Although much research has now accumulated on the dominance of English in world science, attention to the specific reality of Southern European countries has been comparatively scarce. This paper intends to partly redress this imbalance by reporting on survey data gathered at the University of Santiago de Compostela, Spain. Data were collected by…

  8. Purposeful Design of Formal Laboratory Instruction as a Springboard to Research Participation

    ERIC Educational Resources Information Center

    Cartrette, David P.; Miller, Matthew L.

    2013-01-01

    An innovative first- and second-year laboratory course sequence is described. The goal of the instructional model is to introduce chemistry and biochemistry majors to the process of research participation earlier in their academic training. To achieve that goal, the instructional model incorporates significant hands-on experiences with chemical…

  9. Designing a Qualitative Research for Evaluation of English for Academic Purposes Activity in Teacher Education

    ERIC Educational Resources Information Center

    Zascerinska, Jelena

    2010-01-01

    Competence-based teacher education provides new knowledge within the knowledge triangle of education, research and innovation. Communicative competence is of the greatest importance which individuals need for personal fulfilment and development, active citizenship, social inclusion and employment (European Commission, 2004). The successful…

  10. Ethical and Safety Considerations When Obtaining Information From or About Battered Women for Research Purposes

    ERIC Educational Resources Information Center

    Sullivan, Cris M.; Cain, Debra

    2004-01-01

    More and more researchers, evaluators, and policy makers are recognizing that in order to best understand the factors precipitating, supporting, and prohibiting intimate violence against women, we must often gather information directly from battered women themselves. Such data collection, however, is not without its risks to the women involved in…

  11. Research Strategy for Modeling the Complexities of Turbine Heat Transfer

    NASA Technical Reports Server (NTRS)

    Simoneau, Robert J.

    1996-01-01

    The subject of this paper is a NASA research program, known as the Coolant Flow Management Program, which focuses on the interaction between the internal coolant channel and the external film cooling of a turbine blade and/or vane in an aircraft gas turbine engine. The turbine gas path is really a very complex flow field. The combination of strong pressure gradients, abrupt geometry changes and intersecting surfaces, viscous forces, rotation, and unsteady blade/vane interactions all combine to offer a formidable challenge. To this, in the high pressure turbine, we add the necessity of film cooling. The ultimate goal of the turbine designer is to maintain or increase the high level of turbine performance and at the same time reduce the amount of coolant flow needed to achieve this end. Simply stated, coolant flow is a penalty on the cycle and reduces engine thermal efficiency. Accordingly, understanding the flow field and heat transfer associated with the coolant flow is a priority goal. It is important to understand both the film cooling and the internal coolant flow, particularly their interaction. Thus, the motivation for the Coolant Flow Management Program. The paper will begin with a brief discussion of the management and research strategy, will then proceed to discuss the current attack from the internal coolant side, and will conclude by looking at the film cooling effort - at all times keeping sight of the primary goal the interaction between the two. One of the themes of this paper is that complex heat transfer problems of this nature cannot be attacked by single researchers or even groups of researchers, each working alone. It truly needs the combined efforts of a well-coordinated team to make an impact. It is important to note that this is a government/industry/university team effort.

  12. Research Strategy for Modeling the Complexities of Turbine Heat Transfer

    SciTech Connect

    Simoneau, R.J.

    1996-03-01

    The subject of this paper is a NASA research program, known as the Coolant Flow Management Program, which focuses on the interaction between the internal coolant channel and the external film cooling of a turbine blade and/or vane in an aircraft gas turbine engine. The turbine gas path is really a very complex flow field. The combination of strong pressure gradients, abrupt geometry changes and intersecting surfaces, viscous forces, rotation, and unsteady blade/vane interactions all combine to offer a formidable challenge. To this, in the high pressure turbine, one adds the necessity of film cooling. The ultimate goal of the turbine designer is to maintain or increase the high level of turbine performance and at the same time reduce the amount of coolant flow needed to achieve this end. Simply stated, coolant flow is a penalty on the cycle and reduces engine thermal efficiency. Accordingly, understanding the flow field and heat transfer associated with the coolant flow is a priority goal. It is important to understand both the film cooling and the internal coolant flow, particularly their interaction. Thus, the motivation for the Coolant Flow Management Program. The paper will begin with a brief discussion of the management and research strategy, will then proceed to discuss the current attack from the internal coolant side, and will conclude by looking at the film cooling effort - at all times keeping sight of the primary goal the interaction between the two. One of the themes of this paper is that complex heat transfer problems of this nature cannot be attacked by single researchers or even groups of researchers, each working alone. It truly needs the combined efforts of a well-coordinated team to make an impact. It is important to note that this is a government/industry/university team effort.

  13. A proposal for a model of informed consent for the collection, storage and use of biological materials for research purposes.

    PubMed

    Porteri, Corinna; Borry, Pascal

    2008-04-01

    To suggest a model of informed consent for the collection, storage and use of biological materials in local biobanks for health research purposes. Review of the major ethical issues related to collection, storage and use of human biological materials for research purposes. An informed consent form for the collection and use of biological materials in a specific research project, and an informed consent form for the collection, storage and use of biological materials in a biobank were separately developed. Two main rules govern the proposed model, as follows: the informed consent for the use of biological materials shall (i) give donors sufficient information to take informed decisions about possible present and future uses of their biological materials and (ii) consider the specific biological and genetic aims of the research being performed. Even if informed consent for the collection, storage and use of biological materials is a hard process, donors can actually be provided with sufficient information and choices to give a 'really informed consent'. The proposed model can be a useful guideline for the development of specific informed consent forms to be used by researchers. It can also be a good tool to let the donors know which information and guarantees they can request from researchers.

  14. Synergies between plant research conducted for terrestrial and for space purposes

    NASA Astrophysics Data System (ADS)

    André, M.; Chagvardieff, P.

    1999-01-01

    During the past 10 years, the main part of CELSS studies has concerned the exploration of limits of plant productivity. Very high yields were obtained in continuous and high lighting, without reaching any limit. Concepts of mineral nutrition were renewed. CELSS activities now induce a development in the techniques of image processing applied to plants in order to follow the growth, to detect stresses or diseases or to pilot harvesting robots. Notable efforts concern the development of sensors, the study of trace contaminants and the micro-organisms monitoring. In parallel, several instruments for plant culture in closed systems were developed. The advantages of closure are emphasised in comparison with open flow systems. The concept of Artificial Ecosystems developed for space research is more and more taken into account by the scientific community. It is considered as a new tool to study basic and applied problems related to ecology and not especially concerned with space research.

  15. Synergies between plant research conducted for terrestrial and for space purposes.

    PubMed

    Andre, M; Chagvardieff, P

    1999-01-01

    During the past 10 years, the main part of CELSS studies has concerned the exploration of limits of plant productivity. Very high yields were obtained in continuous and high lighting, without reaching any limit. Concepts of mineral nutrition were renewed. CELSS activities now induce a development in the techniques of image processing applied to plants in order to follow the growth, to detect stresses or diseases or to pilot harvesting robots. Notable efforts concern the development of sensors, the study of trace contaminants and the micro-organisms monitoring. In parallel, several instruments for plant culture in closed Systems were developed. The advantages of closure are emphasised in comparison with open flow systems. The concept of Artificial Ecosystems developed for space research is more and more taken into account by the scientific community. It is considered as a new tool to study basic and applied problems related to ecology and not especially concerned with space research.

  16. Purpose, structure, and function of the United States National Dental Practice-Based Research Network

    PubMed Central

    Gilbert, Gregg H.; Williams, O. Dale; Korelitz, James J.; Fellows, Jeffrey L.; Gordan, Valeria V.; Makhija, Sonia K.; Meyerowitz, Cyril; Oates, Thomas W.; Rindal, D. Brad; Benjamin, Paul L.; Foy, Patrick J.

    2013-01-01

    Objective Following a successful2005–2012 phase with three regional practice-based research networks (PBRNs), a single, unified national network called “The National Dental PBRN” was created in 2012 in the United States to improve oral health by conducting practice-based research and serving dental professionals through education and collegiality. Methods Central administration is based in Alabama. Regional centres are based in Alabama, Florida, Minnesota, Oregon, New York and Texas, with a Coordinating Centre in Maryland. Ideas for studies are prioritized by the Executive Committee, comprised mostly of full-time clinicians. Results To date, 2736 persons have enrolled, from all six network regions; enrollment continues to expand. They represent a broad range of practitioners, practice types, and patient populations. Practitioners are actively improving every step of the research process, from idea generation, to study development, field testing, data collection, and presentation and publication. Conclusions Practitioners from diverse settings are partnering with fellow practitioners and academics to improve clinical practice and meet the needs of clinicians and their patients. Clinical significance This “nation’s network” aims to serve as a precious national resource to improve the scientific basis for clinical decision-making and foster movement of the latest evidence into routine practice. PMID:23597500

  17. International Space Science Programs: Basic Research with a High Public Purpose

    NASA Astrophysics Data System (ADS)

    Baker, D. N.

    2009-04-01

    The exploration of outer space, and the use of platforms in space to monitor the Earth, are increasingly international enterprises. The spacefaring nations of the world have programs to study the moon, the Sun, the other planets of the solar system, and the universe beyond. Space is also the domain from which navigation, communication, reconnaissance, and resource management functions are carried out by civilian and military agencies. Recent decades of experience have shown the immense benefits of international cooperation to pursue scientific research goals. In turn, the products of such basic research have immense potential to improve space situational awareness and to mitigate the effects of ''space weather'' on human technology. A key to future success of space exploration is to minimize the impacts of laws and regulations such as ITAR (International Traffic in Arms Regulations) that have already had a devastating effect on space commerce and basic space research. In this presentation I discuss the conduct of forefront science in the context of sensible, prudent international space policy and evolving governmental regulations.

  18. Automated standardized pupillometry with optical method for purposes of clinical practice and research.

    PubMed

    Fotiou, F; Fountoulakis, K N; Goulas, A; Alexopoulos, L; Palikaras, A

    2000-09-01

    The aim of the current study was the introduction and standardization of two experimental conditions for dynamic pupillometry. Pupillometry is a method that can provide valuable data concerning the functioning of the autonomous nervous system. The system for recording the pupil reaction was developed in the Laboratory of Clinical Neurophysiology of the 1st Department of Neurology of Aristotle University of Thessaloniki, in co-operation with the Laboratory of Fluid Mechanics of the Aristotle University of Thessaloniki. This system is fully automated. It includes an infra-red video camera, which has the capacity to record in complete darkness, and an SLE (clinical photic stimulator) lamp. A software application automatically performed all the procedures. During the first experiment, one flash was administered. During the second experiment, a series of 25 flashes (1 Hz frequency) was administered. Fifty physically and mentally healthy subjects aged 23-48 years took part in the study. Means, standard deviations and ranges for all variables characterizing normal subjects during both experimental conditions are reported. Test/re-test results and comparisons of the two eyes are also reported. The combined use of these two experimental conditions in dynamic pupillometry may be a very useful tool in medical research. There are already reports on the usefulness of pupillometry in the research of various diseases, including depression and Alzheimer's disease. It is expected that it will also be a valuable research tool in the study of diabetes, alcoholism, myasthenia gravis, cancer, multiple sclerosis, etc.

  19. Purpose, structure, and function of the United States National Dental Practice-Based Research Network.

    PubMed

    Gilbert, Gregg H; Williams, O Dale; Korelitz, James J; Fellows, Jeffrey L; Gordan, Valeria V; Makhija, Sonia K; Meyerowitz, Cyril; Oates, Thomas W; Rindal, D Brad; Benjamin, Paul L; Foy, Patrick J

    2013-11-01

    Following a successful 2005-2012 phase with three regional practice-based research networks (PBRNs), a single, unified national network called "The National Dental PBRN" was created in 2012 in the United States to improve oral health by conducting practice-based research and serving dental professionals through education and collegiality. Central administration is based in Alabama. Regional centres are based in Alabama, Florida, Minnesota, Oregon, New York and Texas, with a Coordinating Centre in Maryland. Ideas for studies are prioritized by the Executive Committee, comprised mostly of full-time clinicians. To date, 2763 persons have enrolled, from all six network regions; enrollment continues to expand. They represent a broad range of practitioners, practice types, and patient populations. Practitioners are actively improving every step of the research process, from idea generation, to study development, field testing, data collection, and presentation and publication. Practitioners from diverse settings are partnering with fellow practitioners and academics to improve clinical practice and meet the needs of clinicians and their patients. This "nation's network" aims to serve as a precious national resource to improve the scientific basis for clinical decision-making and foster movement of the latest evidence into routine practice. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. AURORA BOREALIS - Icebreaking Deep-Sea Drilling Platform and Multi-Purpose Research Vessel

    NASA Astrophysics Data System (ADS)

    Lembke-Jene, L.; Biebow, N.; Kunz-Pirrung, M.; Thiede, J.; Egerton, P.; Azzolini, R.

    2009-04-01

    Future breakthroughs in scientific deep-sea drilling critically depend on our ability to perform field expeditions with state-of-the-art technologies and modern infrastructures. This will require major investments, both in terms of generating new, as well as maintaining and renovating existing infrastructure. Diverse models for science operations are presently projected, also within the context of scientific needs after the current phase of the IODP will come to an end. In spite of its critical role in global climate and tectonic evolution, the Arctic Ocean is one of the most unexplored ocean basins of the world, its geologic and paleo-environmental history remaining largely unknown. Restricted by circulating sea ice, scientific drilling has been slow to arrive in the Arctic Ocean. This lack of data remains and represents one of the largest gaps of information in modern Earth Science. We here report on the finalised technical planning of a new European research icebreaker and deep-sea drilling vessel, the AURORA BOREALIS, designed with an all-season capability of endurance in permanently ice-covered waters. The icebreaker will be able to carry out deep-sea drilling in ice-covered deep-sea basins primarily during the more favorable summer seasons in order to fulfill the needs of the IODP or its eventual successor as a Mission-Specific Platform. AURORA BOREALIS will be the most advanced polar research vessel in the world with a multi-functional role of drilling in deep ocean basins and supporting climate and environmental research and decision support for stakeholder governments within the next 35-40 years. It will feature the highest attainable icebreaker classification, considerably surpassing in performance all currently operating research icebreakers. New technological features to be implemented include a novel hull design and specialized dynamic positioning systems for operations under closed sea-ice cover conditions with up to 2.5 m ice thickness, combined with

  1. Focused Research Group in Correlated Electron and Complex Materials

    SciTech Connect

    Wang, Ziqiang

    2016-02-17

    While the remarkable physical properties of correlated and complex electronic materials hold great promise for technological applications, one of the key values of the research in this field is its profound impact on fundamental physics. The transition metal oxides, pnictides, and chalcogenides play a key role and occupy an especially important place in this field. The basic reason is that the outer shell of transition metals contains the atomic d-orbitals that have small spatial extent, but not too small to behave as localized orbtials. These d-electrons therefore have a small wave function overlap in a solid, e.g. in an octahedral environment, and form energy bands that are relatively narrow and on the scale of the short-range intra-atomic Coulomb repulsion (Hubbard U). In this intermediate correlation regime lies the challenge of the many-body physics responsible for new and unconventional physical properties. The study of correlated electron and complex materials represents both the challenge and the vitality of condensed matter and materials physics and often demands close collaborations among theoretical and experimental groups with complementary techniques. Our team has a track record and a long-term research goal of studying the unusual complexities and emergent behaviors in the charge, spin, and orbital sectors of the transition metal compounds in order to gain basic knowledge of the quantum electronic states of matter. During the funding period of this grant, the team continued their close collaborations between theory, angle-resolved photoemission spectroscopy, and scanning tunneling microscopy and made significant progress and contributions to the field of iron-based superconductors, copper-oxide high-temperature superconductors, triangular lattice transition metal oxide cobaltates, strontium ruthenates, spin orbital coupled iridates, as well as topological insulators and other topological quantum states of matter. These results include both new

  2. General-Purpose Heat Source: Research and development program: Cold-Process Verification Test Series

    SciTech Connect

    Reimus, M.A.H.; George, T.G.

    1996-06-01

    The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of {sup 238}Pu decay to an array of thermoelectric elements. Because any space mission could experience a launch abort or return from orbit, the heat source must be designed and constructed to survive credible accident environments. Previous testing conducted in support of the Galileo and Ulysses missions documented the response of GPHSs and individual GPHS capsules fueled with {sup 238}UO{sub 2} ({sup 235}U-depleted) to a variety of explosive overpressure and impact events. In the early 1990s, Los Alamos National Laboratory (LANL) resumed fabrication of {sup 238}UO{sub 2} GPHS pellets. The Cold-Process Verification (CPV) Test Series was designed to compare the response of GPHS heat sources loaded with recently fabricated hot- and cold-pressed {sup 238}UO{sub 2} pellets to the response of urania pellets used in the Galileo and Ulysses performance tests. This report documents eleven bare-capsule impacts and one impact of a fully loaded GPHS module. All of the failures observed in the bare-clad impact tests were similar to failures observed in previous safety tests. No failures occurred in the module impact test.

  3. General-purpose heat source: Research and development program. Process evaluation, fuel pellet GF-47

    SciTech Connect

    Reimus, M.A.H.; George, T.G.

    1995-12-01

    The general-purpose heat source (GPHS) provides power for space missions by transmitting the heat of {sup 238}Pu decay to an array of thermoelectric elements. Because the potential for a launch abort or return from orbit exists for any space mission, the heat source must be designed and constructed to survive credible accident environments. Previous testing conducted in support of the Galileo and Ulysses missions has documented the response of the GPHS heat source to a variety of fragment-impact, aging, atmospheric reentry, and Earth-impact conditions. Although heat sources for previous missions were fabricated by the Westinghouse Savannah River Company (WSRC), GPHS fueled-clads required for the Cassini mission to Saturn will be fabricated by Los Alamos National Laboratory (LANL). This evaluation is part of an ongoing program to determine the similarity of GPHS fueled clads and fuel pellets fabricated at LANL to those fabricated at WSRC. Pellet GF-47, which was fabricated at LANL in late 1994, was submitted for chemical and ceramographic analysis. The results indicated that the pellet had a chemical makeup and microstructure within the range of material fabricated at WSRC in the early 1980s.

  4. AURORA BOREALIS - Icebreaker, Drilling Platform and Multi-Purpose Research Vessel

    NASA Astrophysics Data System (ADS)

    Kunz-Pirrung, M.; Biebow, N.; Lembke-Jene, L.; Thiede, J.; Egerton, P.

    2007-12-01

    In spite of the critical role of the Arctic Ocean in climate evolution, it is the only sub-basin of the world's oceans that has essentially not been sampled by the drill ships of the Deep-Sea Drilling Project (DSDP) or the Ocean Drilling Program (ODP), and its long-term environmental history and tectonic structure is therefore poorly known. Exceptions are the ODP Leg 151 and the more recent very successful ACEX-expedition of the Integrated Ocean Drilling Program (IODP). This lack of data represents one of the largest gaps of information in modern Earth Science. Therefore, the new research icebreaker AURORA BOREALIS will be equipped with drilling facilities to fulfil the needs of the IODP for a -Mission-Specific Platform- to drill in deep, permanently ice-covered ocean basins. This icebreaker must be also powerful enough to maintain station against the drifting sea-ice cover and will have to be equipped with a dynamic positioning system. This new icebreaker would be conceived as an optimized science platform from the keel up and will allow conducting long, international and interdisciplinary expeditions into the central Arctic Ocean during all seasons of the year. In a long-term perspective the AURORA BOREALIS will also be used to address Antarctic research targets, both in its mode as a regular research vessel as well as a polar drill ship. The construction of AURORA BOREALIS requires several new technical implementations, such as advanced dynamic positioning and deep-sea drilling under a closed sea-ice cover and two moon pools (7 x 7 m), and will provide an extended technical potential and knowledge for marine technology. The scientific and technical details will be presented.

  5. From the Bronx to Bengifunda (and other lines of flight): deterritorializing purposes and methods in science education research

    NASA Astrophysics Data System (ADS)

    Gough, Noel

    2011-03-01

    In this essay I explore a number of questions about purposes and methods in science education research prompted by my reading of Wesley Pitts' ethnographic study of interactions among four students and their teacher in a chemistry classroom in the Bronx, New York City. I commence three `lines of flight' (small acts of Deleuzo-Guattarian deterritorialization) that depart from the conceptual territory regulated by science education's dominant systems of signification and make new connections within and beyond that territory. I offer neither a comprehensive review nor a thorough critique of Wesley's paper but, rather, suggest some alternative directions for science education research in the genre he exemplifies.

  6. AILA Africa Research Network Launch 2007: Research into the Use of the African Languages for Academic Purposes

    ERIC Educational Resources Information Center

    Wildsmith-Cromarty, Rosemary

    2009-01-01

    The aim of the one-day symposium was to bring together scholars in applied linguistics with an interest in the African languages for the launch of the new AILA Africa regional network. Contributions were in the form of invited research papers from several African countries. This report focuses on the South African contribution, which highlighted…

  7. AILA Africa Research Network Launch 2007: Research into the Use of the African Languages for Academic Purposes

    ERIC Educational Resources Information Center

    Wildsmith-Cromarty, Rosemary

    2009-01-01

    The aim of the one-day symposium was to bring together scholars in applied linguistics with an interest in the African languages for the launch of the new AILA Africa regional network. Contributions were in the form of invited research papers from several African countries. This report focuses on the South African contribution, which highlighted…

  8. Will Women Diagnosed with Breast Cancer Provide Biological Samples for Research Purposes?

    PubMed

    Harris, Shelley A; Boucher, Beatrice A; Cotterchio, Michelle

    2015-01-01

    Little is known about the response rates for biological sample donation and attitudes towards control recruitment, especially in younger women. The goals of this pilot study were to determine in women recently diagnosed with breast cancer, the proportion of cases willing to provide biological samples and for purposes of control recruitment, contact information for friends or colleagues. A population-based sample of breast cancer cases (n = 417, 25-74 years) was recruited from the Ontario Cancer Registry in 2010 and self-administered questionnaires were completed to determine willingness to provide samples (spot or 24-hr urine, saliva, blood) and contact information for friends/colleagues for control recruitment. Using Χ2 analyses of contingency tables we evaluated if these proportions varied by age group (<45 and 45+) and other factors such as ethnicity, education, income, body mass index (BMI), smoking status and alcohol consumption. Cases were willing to provide blood samples, by visiting a clinic (62%) or by having a nurse visit the home (61%). Moreover, they would provide saliva (73%), and morning or 24-hr urine samples (66% and 52%). Younger cases (≤45) were 3 times (OR) more likely more than older cases to agree to collect morning urine (95% CI: 1.15-8.35). Only 26% of cases indicated they would provide contact information of friends or work colleagues to act as controls. Educated cases were more likely to agree to provide samples, and cases who consumed alcohol were more willing to provide contact information. Ethnicity, income, BMI and smoking had little effect on response rates. Reasonable response rates for biological sample collection should be expected in future case controls studies in younger women, but other methods of control selection must be devised.

  9. Recommended Ethical Safeguards on Fertilization of Human Germ Cells Derived from Pluripotent Stem Cells Solely for Research Purposes.

    PubMed

    Mizuno, Hiroshi

    2016-08-01

    Production of human fertilized embryos by using germ cells derived from pluripotent stem cells (PSCs) entails ethical issues that differ fundamentally depending on the aim. If the aim is solely to conduct research, then embryo generation, utilization and destruction must respect for the human embryo as having the innate potential to develop into a human being. If the aim is human reproduction, this technology must never be used to manipulate human life, confuse social order, or negatively affect future generations. Researchers should distinguish the aims and then accordingly establish a consensus on the safeguards needed to proceed with scientifically significant and socially accepted research, or otherwise set a moratorium. Currently, in Japan, germ cell production from human PSCs is permitted, whereas fertilization of these germ cells is not. The Japanese Expert Panel on Bioethics in the Cabinet Office has proposed that all of the following conditions must be met to approve fertilization for research purposes: (1) the research is significant for the life sciences and medicine; (2) the benefits or anticipated benefits are socially accepted; (3) human safety is assured; and (4) safeguards are put in place. If fertilization is ethically approved, I recommend the following safeguards: limitation of the purpose to improving conventional ART as an initial step; permitted culture of human embryos until the appearance of the primitive streak; restriction of the number of embryos produced to the minimum necessary; prohibition of transplantation into a human or animal uterus; and provision of human-derived ova that are not required for ART treatment.

  10. Eco-efficiency analysis of an agricultural research complex.

    PubMed

    Reith, Charles C; Guidry, Michael J

    2003-07-01

    The Model Sustainable Agricultural Complex (MSAC) is a 600-acre experimental farm in south-central Louisiana, in the very southern reaches of the United States, approximately 40 km north of the Gulf of Mexico. The MSAC consists of many land uses and facilities, including a dairy, crawfish center, beef herd, sugarcane crop, and equestrian center, as well as numerous features and programs for research, education, and residence. The mission of the MSAC, which is operated by the Department of Renewable Resources at the University of Louisiana at Lafayette, has been to accommodate research and education in production agriculture, while generating revenues through the delivery of food products into the local economy. In recent years, environmental conservation has been increasingly important at the MSAC. Best management practices (BMPs) were implemented to reduce soil loss and mitigate nonpoint source pollution. Research was initiated to quantify the effectiveness of these BMPs, and workshops were conducted to explain preliminary results to local farmers. However, environmental improvements at the MSAC had until 2000 been piecemeal, which may be said as well for agriculture overall. What is needed is a comprehensive integrated approach to analyzing and improving environmental performance, as is possible when implementing an environmental management system (EMS). This manuscript describes our efforts to integrate piecemeal environmental improvements into a farm-wide program of systematic improvement. This process began with a qualitative ranking of the MSAC's inputs and outputs, followed by a quantification of certain key parameters related to the consumption of resources and provision of services at the Complex. Certain measures related to the Complex's eco-efficiency were combined into a ratio that provides a useful target for management and continuous improvement. Eco-efficiency, which is defined as 'the efficiency with which receivables are converted into deliverables

  11. Monitoring of equine health in Denmark: the importance, purpose, research areas and content of a future database.

    PubMed

    Hartig, Wendy; Houe, Hans; Andersen, Pia Haubro

    2013-04-01

    The plentiful data on Danish horses are currently neither organized nor easily accessible, impeding register-based epidemiological studies on Danish horses. A common database could be beneficial. In principle, databases can contain a wealth of information, but no single database can serve every purpose. Hence the establishment of a Danish equine health database should be preceded by careful consideration of its purpose and content, and stakeholder attitudes should be investigated. The objectives of the present study were to identify stakeholder attitudes to the importance, purpose, research areas and content of a health database for horses in Denmark. A cross-sectional study was conducted with 13 horse-related stakeholder groups in Denmark. The groups surveyed included equine veterinarians, researchers, veterinary students, representatives from animal welfare organizations, horse owners, trainers, farriers, authority representatives, ordinary citizens, and representatives from laboratories, insurance companies, medical equipment companies and pharmaceutical companies. Supplementary attitudes were inferred from qualitative responses. The overall response rate for all stakeholder groups was 45%. Stakeholder group-specific response rates were 27-80%. Sixty-eight percent of questionnaire respondents thought a national equine health database was important. Most respondents wanted the database to contribute to improved horse health and welfare, to be used for research into durability and disease heritability, and to serve as a basis for health declarations for individual horses. The generally preferred purpose of the database was thus that it should focus on horse health and welfare rather than on performance or food safety, and that it should be able to function both at a population and an individual horse level. In conclusion, there is a positive attitude to the establishment of a health database for Danish horses. These results could enrich further reflection on the

  12. Complex geophysical research for defining the defensive wall of the archaeological area "Skupi"

    NASA Astrophysics Data System (ADS)

    Delipetrev, Marjan; Zlatkov, Goce; Delipetrev, Todor; Panov, Zoran

    2017-04-01

    Depending on the purpose of the tests, geophysical surveys are much more effective when carried out with application of several geophysical methods which complement interpreted data. Geophysical surveys presented in the scientific work are based on the complementary use of several geophysical methods with which through complex interpretation would give a precise location of the archaeological site with known structure covered with sedimentary material. The adequate geophysical methods are determined based on ground conditions and physical parameters according to which the surface area would be modeled effectively. The research presented in the scientific work is made through the use of geo - electrical, seismic and geo - magnetic surveys. The methods of geo - electric mapping and shallow seismic refraction and reflection is presented as an investigative methodology, while the prospection of the tested area is made with geo - magnetic method. Through the mentioned methods are defined the conductive, geo - mechanical and magnetic characteristics of the geological complex.

  13. DC Motor Drive for Small Autonomous Robots with Educational and Research Purpose

    NASA Astrophysics Data System (ADS)

    Krklješ, Damir; Babković, Kalman; Nagy, László; Borovac, Branislav; Nikolić, Milan

    Many student robot competitions have been established during the last decade. One of them, and the most popular in Europe, is the European competition EUROBOT. The basic aim of this competition is to promote the robotics among young people, mostly students and high school pupils. The additional outcome of the competition is the development of faculty curriculums that are based on this competition. Such curriculum has been developed at the Faculty of Technical Science in Novi Sad. The curriculum duration is two semesters. During the first semester the theoretical basis is presented to the students. During the second semester the students, divided into teams of three to five students, develop the robots which will take part in the incoming EUROBOT competition. Since the time for the robot development is short, the basic electronic kit is provided for the students. The basic parts of the kit are two DC motor drives dedicated to the robot locomotion. The drives will also be used in the research concerning the multi segment robot foot. This paper presents the DC motor drive and its features. The experimental results concerning speed and position regulations and also the current limiting is presented too.

  14. Space Propulsion Research Facility (B-2): An Innovative, Multi-Purpose Test Facility

    NASA Technical Reports Server (NTRS)

    Hill, Gerald M.; Weaver, Harold F.; Kudlac, Maureen T.; Maloney, Christian T.; Evans, Richard K.

    2011-01-01

    The Space Propulsion Research Facility, commonly referred to as B-2, is designed to hot fire rocket engines or upper stage launch vehicles with up to 890,000 N force (200,000 lb force), after environmental conditioning of the test article in simulated thermal vacuum space environment. As NASA s third largest thermal vacuum facility, and the largest designed to store and transfer large quantities of propellant, it is uniquely suited to support developmental testing associated with large lightweight structures and Cryogenic Fluid Management (CFM) systems, as well as non-traditional propulsion test programs such as Electric and In-Space propulsion. B-2 has undergone refurbishment of key subsystems to support the NASA s future test needs, including data acquisition and controls, vacuum, and propellant systems. This paper details the modernization efforts at B-2 to support the Nation s thermal vacuum/propellant test capabilities, the unique design considerations implemented for efficient operations and maintenance, and ultimately to reduce test costs.

  15. Research on complex networks' repairing characteristics due to cascading failure

    NASA Astrophysics Data System (ADS)

    Chaoqi, Fu; Ying, Wang; Xiaoyang, Wang

    2017-09-01

    In reality, most of the topological structures of complex networks are not ideal. Considering the restrictions from all aspects, we cannot timely adjust and improve network defects. Once complex networks collapse under cascading failure, an appropriate repair strategy must be implemented. This repair process is divided into 3 kinds of situations. Based on different types of opening times, we presented 2 repair modes, and researched 4 kinds of repair strategies. Results showed that network efficiency recovered faster when the repair strategies were arranged in descending order by parameters under the immediate opening condition. However, the risk of secondary failure and additional expansion capacity were large. On the contrary, when repair strategies were in ascending order, the demand for additional capacity caused by secondary failure was greatly saved, but the recovery of network efficiency was relatively slow. Compared to immediate opening, delayed opening alleviated the contradiction between network efficiency and additional expansion capacity, particularly to reduce the risk of secondary failure. Therefore, different repair methods have different repair characteristics. This paper investigates the impact of cascading effects on the network repair process, and by presenting a detailed description of the status of each repaired node, helps us understand the advantages and disadvantages of different repair strategies.

  16. KID Project: an internet-based digital video atlas of capsule endoscopy for research purposes.

    PubMed

    Koulaouzidis, Anastasios; Iakovidis, Dimitris K; Yung, Diana E; Rondonotti, Emanuele; Kopylov, Uri; Plevris, John N; Toth, Ervin; Eliakim, Abraham; Wurm Johansson, Gabrielle; Marlicz, Wojciech; Mavrogenis, Georgios; Nemeth, Artur; Thorlacius, Henrik; Tontini, Gian Eugenio

    2017-06-01

     Capsule endoscopy (CE) has revolutionized small-bowel (SB) investigation. Computational methods can enhance diagnostic yield (DY); however, incorporating machine learning algorithms (MLAs) into CE reading is difficult as large amounts of image annotations are required for training. Current databases lack graphic annotations of pathologies and cannot be used. A novel database, KID, aims to provide a reference for research and development of medical decision support systems (MDSS) for CE.  Open-source software was used for the KID database. Clinicians contribute anonymized, annotated CE images and videos. Graphic annotations are supported by an open-access annotation tool (Ratsnake). We detail an experiment based on the KID database, examining differences in SB lesion measurement between human readers and a MLA. The Jaccard Index (JI) was used to evaluate similarity between annotations by the MLA and human readers.  The MLA performed best in measuring lymphangiectasias with a JI of 81 ± 6 %. The other lesion types were: angioectasias (JI 64 ± 11 %), aphthae (JI 64 ± 8 %), chylous cysts (JI 70 ± 14 %), polypoid lesions (JI 75 ± 21 %), and ulcers (JI 56 ± 9 %).  MLA can perform as well as human readers in the measurement of SB angioectasias in white light (WL). Automated lesion measurement is therefore feasible. KID is currently the only open-source CE database developed specifically to aid development of MDSS. Our experiment demonstrates this potential.

  17. Implications of complex adaptive systems theory for the design of research on health care organizations

    PubMed Central

    McDaniel, Reuben R.; Lanham, Holly Jordan; Anderson, Ruth A.

    2013-01-01

    Background Because health care organizations (HCOs) are complex adaptive systems (CASs), phenomena of interest often are dynamic and unfold in unpredictable ways, and unfolding events are often unique. Researchers of HCOs may recognize that the subject of their research is dynamic; however, their research designs may not take this into account. Researchers may also know that unfolding events are often unique, but their design may not have the capacity to obtain information from meager evidence. Purpose These two concerns led us to examine two ideas from organizational theory: (a) the ideas of K. E. Weick (1993) on organizational design as a verb and (b) the ideas of J. G. March, L. S. Sproull, and M. Tamuz (1991) on learning from samples of one or fewer. In this article, we applied these ideas to develop an enriched perspective of research design for studying CASs. Methodology/Approach We conducted a theoretical analysis of organizations as CASs, identifying relevant characteristics for research designs. We then explored two ideas from organizational theory and discussed the implications for research designs. Findings Weick's idea of “design as a verb” helps in understanding dynamic and process-oriented research design. The idea of “learning from samples of one or fewer” of March, Sproull, and Tamuz provides strategies for research design that enables learning from meager evidence. When studying HCOs, research designs are likely to be more effective when they (a) anticipate change, (b) include tension, (c) capitalize on serendipity, and (d) use an “act-then-look” mind set. Implications for practice are discussed. Practice Implications Practitioners who understand HCOs as CASs will be cautious in accepting findings from studies that treat HCOs mechanistically. They will consider the characteristics of CAS when evaluating the evidence base for practice. Practitioners can use the strategies proposed in this article to stimulate discussion with researchers

  18. Applications of complex systems theory in nursing education, research, and practice.

    PubMed

    Clancy, Thomas R; Effken, Judith A; Pesut, Daniel

    2008-01-01

    The clinical and administrative processes in today's healthcare environment are becoming increasingly complex. Multiple providers, new technology, competition, and the growing ubiquity of information all contribute to the notion of health care as a complex system. A complex system (CS) is characterized by a highly connected network of entities (e.g., physical objects, people or groups of people) from which higher order behavior emerges. Research in the transdisciplinary field of CS has focused on the use of computational modeling and simulation as a methodology for analyzing CS behavior. The creation of virtual worlds through computer simulation allows researchers to analyze multiple variables simultaneously and begin to understand behaviors that are common regardless of the discipline. The application of CS principles, mediated through computer simulation, informs nursing practice of the benefits and drawbacks of new procedures, protocols and practices before having to actually implement them. The inclusion of new computational tools and their applications in nursing education is also gaining attention. For example, education in CSs and applied computational applications has been endorsed by The Institute of Medicine, the American Organization of Nurse Executives and the American Association of Colleges of Nursing as essential training of nurse leaders. The purpose of this article is to review current research literature regarding CS science within the context of expert practice and implications for the education of nurse leadership roles. The article focuses on 3 broad areas: CS defined, literature review and exemplars from CS research and applications of CS theory in nursing leadership education. The article also highlights the key role nursing informaticists play in integrating emerging computational tools in the analysis of complex nursing systems.

  19. Managing complex research datasets using electronic tools: A meta-analysis exemplar

    PubMed Central

    Brown, Sharon A.; Martin, Ellen E.; Garcia, Theresa J.; Winter, Mary A.; García, Alexandra A.; Brown, Adama; Cuevas, Heather E.; Sumlin, Lisa L.

    2013-01-01

    Meta-analyses of broad scope and complexity require investigators to organize many study documents and manage communication among several research staff. Commercially available electronic tools, e.g., EndNote, Adobe Acrobat Pro, Blackboard, Excel, and IBM SPSS Statistics (SPSS), are useful for organizing and tracking the meta-analytic process, as well as enhancing communication among research team members. The purpose of this paper is to describe the electronic processes we designed, using commercially available software, for an extensive quantitative model-testing meta-analysis we are conducting. Specific electronic tools improved the efficiency of (a) locating and screening studies, (b) screening and organizing studies and other project documents, (c) extracting data from primary studies, (d) checking data accuracy and analyses, and (e) communication among team members. The major limitation in designing and implementing a fully electronic system for meta-analysis was the requisite upfront time to: decide on which electronic tools to use, determine how these tools would be employed, develop clear guidelines for their use, and train members of the research team. The electronic process described here has been useful in streamlining the process of conducting this complex meta-analysis and enhancing communication and sharing documents among research team members. PMID:23681256

  20. Managing complex research datasets using electronic tools: a meta-analysis exemplar.

    PubMed

    Brown, Sharon A; Martin, Ellen E; Garcia, Theresa J; Winter, Mary A; García, Alexandra A; Brown, Adama; Cuevas, Heather E; Sumlin, Lisa L

    2013-06-01

    Meta-analyses of broad scope and complexity require investigators to organize many study documents and manage communication among several research staff. Commercially available electronic tools, for example, EndNote, Adobe Acrobat Pro, Blackboard, Excel, and IBM SPSS Statistics (SPSS), are useful for organizing and tracking the meta-analytic process as well as enhancing communication among research team members. The purpose of this article is to describe the electronic processes designed, using commercially available software, for an extensive, quantitative model-testing meta-analysis. Specific electronic tools improved the efficiency of (a) locating and screening studies, (b) screening and organizing studies and other project documents, (c) extracting data from primary studies, (d) checking data accuracy and analyses, and (e) communication among team members. The major limitation in designing and implementing a fully electronic system for meta-analysis was the requisite upfront time to decide on which electronic tools to use, determine how these tools would be used, develop clear guidelines for their use, and train members of the research team. The electronic process described here has been useful in streamlining the process of conducting this complex meta-analysis and enhancing communication and sharing documents among research team members.

  1. Alternatives of informed consent for storage and use of human biological material for research purposes: Brazilian regulation.

    PubMed

    Marodin, Gabriela; França, Paulo Henrique Condeixa de; Salgueiro, Jennifer Braathen; Motta, Marcia Luz da; Tannous, Gysélle Saddi; Lopes, Anibal Gil

    2014-12-01

    Informed consent is recognized as a primary ethical requirement to conduct research involving humans. In the investigations with the use of human biological material, informed consent (IC) assumes a differentiated condition on account of the many future possibilities. This work presents suitable alternatives for IC regarding the storage and use of human biological material in research, according to new Brazilian regulations. Both norms - Resolution 441/11 of the National Health Council, approved on 12 May 2011, and Ordinance 2.201 (NATIONAL GUIDELINES FOR BIOREPOSITORIES AND BIOBANKS OF HUMAN BIOLOGICAL MATERIAL FOR RESEARCH PURPOSE) of the Brazil Ministry of Health, approved on 14 September 2011 - state that the consent of subjects for the collection, storage and use of samples stored in Biobanks is necessarily established by means of a Free and Informed Consent Form (ICF). In order to obtain individual and formal statements, this form should contain the following two mutually exclusive options: an explanation about the use of the stored material in each research study, and the need for new consent or the waiver thereof when the material is used for a new study. On the other hand, ICF suitable for Biorepositories must be exclusive and related to specific research. Although Brazilian and international regulations identify the main aspects to be included in the IC, efforts are still necessary to improve the consent process, so that the document will become a bond of trust between subject and researcher. © 2012 John Wiley & Sons Ltd.

  2. Young people's views about the purpose and composition of research ethics committees: findings from the PEARL qualitative study.

    PubMed

    Audrey, Suzanne; Brown, Lindsey; Campbell, Rona; Boyd, Andy; Macleod, John

    2016-09-02

    Avon Longitudinal Study of Parents and Children (ALSPAC) is a birth cohort study within which the Project to Enhance ALSPAC through Record Linkage (PEARL) was established to enrich the ALSPAC resource through linkage between ALSPAC participants and routine sources of health and social data. PEARL incorporated qualitative research to seek the views of young people about data linkage, including their opinions about appropriate safeguards and research governance. In this paper we focus on views expressed about the purpose and composition of research ethics committees. Digitally recorded interviews were conducted with 48 participants aged 17-19 years. Participants were asked about whether medical research should be monitored and controlled, their knowledge of research ethics committees, who should sit on these committees and what their role should be. Interview recordings were fully transcribed and anonymised. Thematic analysis was undertaken, assisted by the Framework approach to data management. The majority of interviewees had little or no specific knowledge of ethics committees. Once given basic information about research ethics committees, only three respondents suggested there was no need for such bodies to scrutinise research. The key tasks of ethics committees were identified as monitoring the research process and protecting research participants. The difficulty of balancing the potential to inhibit research against the need to protect research participants was acknowledged. The importance of relevant research and professional expertise was identified but it was also considered important to represent wider public opinion, and to counter the bias potentially associated with self-selection possibly through a selection process similar to 'jury duty'. There is a need for more education and public awareness about the role and composition of research ethics committees. Despite an initial lack of knowledge, interviewees were able to contribute their ideas and balance

  3. The evaluation of complex interventions in palliative care: an exploration of the potential of case study research strategies.

    PubMed

    Walshe, Catherine

    2011-12-01

    Complex, incrementally changing, context dependent and variable palliative care services are difficult to evaluate. Case study research strategies may have potential to contribute to evaluating such complex interventions, and to develop this field of evaluation research. This paper explores definitions of case study (as a unit of study, a process, and a product) and examines the features of case study research strategies which are thought to confer benefits for the evaluation of complex interventions in palliative care settings. Ten features of case study that are thought to be beneficial in evaluating complex interventions in palliative care are discussed, drawing from exemplars of research in this field. Important features are related to a longitudinal approach, triangulation, purposive instance selection, comprehensive approach, multiple data sources, flexibility, concurrent data collection and analysis, search for proving-disproving evidence, pattern matching techniques and an engaging narrative. The limitations of case study approaches are discussed including the potential for subjectivity and their complex, time consuming and potentially expensive nature. Case study research strategies have great potential in evaluating complex interventions in palliative care settings. Three key features need to be exploited to develop this field: case selection, longitudinal designs, and the use of rival hypotheses. In particular, case study should be used in situations where there is interplay and interdependency between the intervention and its context, such that it is difficult to define or find relevant comparisons.

  4. Comparative evaluation of two Rickettsia typhi-specific quantitative real-time PCRs for research and diagnostic purposes.

    PubMed

    Papp, Stefanie; Rauch, Jessica; Kuehl, Svenja; Richardt, Ulricke; Keller, Christian; Osterloh, Anke

    2017-02-01

    Rickettsioses are caused by intracellular bacteria of the family of Rickettsiaceae. Rickettsia (R.) typhi is the causative agent of endemic typhus. The disease occurs worldwide and is one of the most prevalent rickettsioses. Rickettsial diseases, however, are generally underdiagnosed which is mainly due to the lack of sensitive and specific methods. In addition, methods for quantitative detection of the bacteria for research purposes are rare. We established two qPCRs for the detection of R. typhi by amplification of the outer membrane protein B (ompB) and parvulin-type PPIase (prsA) genes. Both qPCRs are specific and exclusively recognize R. typhi but no other rickettsiae including the closest relative, R. prowazekii. The prsA-based qPCR revealed to be much more sensitive than the amplification of ompB and provided highly reproducible results in the detection of R. typhi in organs of infected mice. Furthermore, as a nested PCR the prsA qPCR was applicable for the detection of R. typhi in human blood samples. Collectively, the prsA-based qPCR represents a reliable method for the quantitative detection of R. typhi for research purposes and is a promising candidate for differential diagnosis.

  5. Audio-visual recording of patient-GP consultations for research purposes: a literature review on recruiting rates and strategies.

    PubMed

    Themessl-Huber, Markus; Humphris, Gerry; Dowell, Jon; Macgillivray, Steve; Rushmer, Rosemary; Williams, Brian

    2008-05-01

    To identify ethical processes and recruitment strategies, participation rates of studies using audio or video recording of primary health care consultations for research purposes, and the effect of recording on the behaviour, attitudes and feelings of participants. A structured literature review using Medline, Embase, Cochrane Library, and Psychinfo. This was followed by extensive hand search. Recording consultations were regarded as ethically acceptable with some additional safeguards recommended. A range of sampling and recruitment strategies were identified although specific detail was often lacking. Non-participation rates in audio-recording studies ranged from 3 to 83% for patients and 7 to 84% for GPs; in video-recording studies they ranged from 0 to 83% for patients and 0 to 93% for GPs. There was little evidence to suggest that recording significantly affects patient or practitioner behaviour. Research involving audio or video recording of consultations is both feasible and acceptable. More detailed reporting of the methodical characteristics of recruitment in the published literature is needed. Researchers should consider the impact of diverse sampling and recruitment strategies on participation levels. Participants should be informed that there is little evidence that recording consultations negatively affects their content or the decisions made. Researchers should increase reporting of ethical and recruitment processes in order to facilitate future reviews and meta-analyses.

  6. Complexity Science and Educational Action Research: Toward a Pragmatics of Transformation

    ERIC Educational Resources Information Center

    Davis, Brent; Sumara, Dennis

    2005-01-01

    In this article, the authors extend Phelps & Hase's (2002) explorations of the theoretical and methodological connections of complexity theory and action research by emphasizing complexity science as the study of learning systems. By emphasizing the importance of "complexity thinking", an argument is made for conceptualizing action research as a…

  7. Dealing with Complexity: New Paradigms for Research in Mathematics Education.

    ERIC Educational Resources Information Center

    Lesh, Richard

    This paper focuses on some of the most important factors that appear to have strongly influenced the development of the dominant research designs used in mathematics education research. Factors discussed that have influenced research design in mathematics education include a concern about increasing the relevance of research to practice and the…

  8. Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents

    PubMed Central

    Wender, Paul A.; Fournogerakis, Dennis N.; Jeffreys, Matthew S.; Quiroz, Ryan V.; Inagaki, Fuyuhiko; Pfaffenbach, Magnus

    2014-01-01

    Multicomponent reactions allow for more bond-forming events per synthetic operation, enabling more step and time economical conversion of simple starting materials to complex and thus value-added targets. These processes invariably require that reactivity be relayed from intermediate to intermediate over several mechanistic steps until a termination event produces the final product. Here we report a multicomponent process in which a novel 1,2,3-butatriene equivalent (TMSBO: TMSCH2C≡CCH2OH) engages chemospecifically as a two-carbon alkyne component in a metal-catalyzed [5+2] cycloaddition with a vinylcyclopropane to produce an intermediate cycloadduct. Under the reaction conditions, this intermediate undergoes a remarkably rapid 1,4-Peterson elimination, producing a reactive four-carbon diene intermediate that is readily intercepted in either a metal-catalyzed or thermal [4+2] cycloaddition. TMSBO thus serves as an yne-to-diene transmissive reagent coupling two powerful and convergent cycloadditions - the homologous Diels-Alder and Diels-Alder cycloadditions - through a vinylogous Peterson elimination, and enabling flexible access to diverse polycycles. PMID:24755598

  9. Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents

    NASA Astrophysics Data System (ADS)

    Wender, Paul A.; Fournogerakis, Dennis N.; Jeffreys, Matthew S.; Quiroz, Ryan V.; Inagaki, Fuyuhiko; Pfaffenbach, Magnus

    2014-05-01

    Multicomponent reactions allow for more bond-forming events per synthetic operation, enabling more step- and time-economical conversion of simple starting materials to complex and thus value-added targets. These processes invariably require that reactivity be relayed from intermediate to intermediate over several mechanistic steps until a termination event produces the final product. Here, we report a multicomponent process in which a novel 1,2,3-butatriene equivalent (TMSBO: TMSCH2C≡CCH2OH) engages chemospecifically as a two-carbon alkyne component in a metal-catalysed [5 + 2] cycloaddition with a vinylcyclopropane to produce an intermediate cycloadduct. Under the reaction conditions, this intermediate undergoes a remarkably rapid 1,4-Peterson elimination, producing a reactive four-carbon diene intermediate that is readily intercepted in either a metal-catalysed or thermal [4 + 2] cycloaddition. TMSBO thus serves as an yne-to-diene transmissive reagent coupling two powerful and convergent cycloadditions—the homologous Diels-Alder and Diels-Alder cycloadditions—through a vinylogous Peterson elimination, and enabling flexible access to diverse polycycles.

  10. Mobile hyper spectral optical complex for under satellite ocean research

    NASA Astrophysics Data System (ADS)

    Nagorniy, Ivan G.; Mayor, Alexander Y.; Salyuk, Pavel A.; Krikun, Vladimir A.

    2015-11-01

    This paper presents the mobile complex to perform continuous measurements of chlorophyll-A concentrations and dissolved organic matter by the laser induced fluorescence method. The obtained data allow evaluating the state of the photosynthetic system of phytoplankton cells. In addition, the complex allows recording the CO2 gas analyzer data, the sea water saltiness sensors, pH, temperature, and solar illumination meter. The mobility this complex ensures a possibility working on different ships and under stationary conditions. The configuration of the complex can be promptly changed for solving the current problem by promptly adding or replacing various devices and sensors. The developed software integrates all devices into the complex. The enclosure of system allows use of conventional laboratory equipment, which is resistant to vibration, but not protected from the effects of the marine environment. Results of in situ measurements performed in Sea of Japan (Peter the Great Bay) by experimental setup are given.

  11. CASE STUDY RESEARCH: THE VIEW FROM COMPLEXITY SCIENCE

    PubMed Central

    Anderson, Ruth; Crabtree, Benjamin F.; Steele, David J.; McDaniel, Reuben R.

    2005-01-01

    Many wonder why there has been so little change in care quality, despite substantial quality improvement efforts. Questioning why current approaches are not making true changes draws attention to the organization as a source of answers. We bring together the case study method and complexity science to suggest new ways to study health care organizations. The case study provides a method for studying systems. Complexity theory suggests that keys to understanding the system are contained in patterns of relationships and interactions among the system’s agents. We propose some of the “objects” of study that are implicated by complexity theory and discuss how studying these using case methods may provide useful maps of the system. We offer complexity theory, partnered with case study method, as a place to begin the daunting task of studying a system as an integrated whole. PMID:15802542

  12. Aerial Survey of Ames Research Center - Flight Simulation Complex' Flight simulators create an

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Aerial Survey of Ames Research Center - Flight Simulation Complex' Flight simulators create an authentic aircraft environment by generating the appropriate physical cues that provide the sensations of flight.

  13. Moving Virtual Research Environments from high maintenance Stovepipes to Multi-purpose Sustainable Service-oriented Science Platforms

    NASA Astrophysics Data System (ADS)

    Klump, Jens; Fraser, Ryan; Wyborn, Lesley; Friedrich, Carsten; Squire, Geoffrey; Barker, Michelle; Moloney, Glenn

    2017-04-01

    The researcher of today is likely to be part of a team distributed over multiple sites that will access data from an external repository and then process the data on a public or private cloud or even on a large centralised supercomputer. They are increasingly likely to use a mixture of their own code, third party software and libraries, or even access global community codes. These components will be connected into a Virtual Research Environments (VREs) that will enable members of the research team who are not co-located to actively work together at various scales to share data, models, tools, software, workflows, best practices, infrastructures, etc. Many VRE's are built in isolation: designed to meet a specific research program with components tightly coupled and not capable of being repurposed for other use cases - they are becoming 'stovepipes'. The limited number of users of some VREs also means that the cost of maintenance per researcher can be unacceptably high. The alternative is to develop service-oriented Science Platforms that enable multiple communities to develop specialised solutions for specific research programs. The platforms can offer access to data, software tools and processing infrastructures (cloud, supercomputers) through globally distributed, interconnected modules. In Australia, the Virtual Geophysics Laboratory (VGL) was initially built to enable a specific set of researchers in government agencies access to specific data sets and a limited number of tools, that is now rapidly evolving into a multi-purpose Earth science platform with access to an increased variety of data, a broader range of tools, users from more sectors and a diversity of computational infrastructures. The expansion has been relatively easy, because of the architecture whereby data, tools and compute resources are loosely coupled via interfaces that are built on international standards and accessed as services wherever possible. In recent years, investments in

  14. 42 CFR 68a.1 - What is the scope and purpose of the NIH Clinical Research Loan Repayment Program for Individuals...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What is the scope and purpose of the NIH Clinical..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.1 What is the scope and purpose of the NIH...

  15. 42 CFR 68a.1 - What is the scope and purpose of the NIH Clinical Research Loan Repayment Program for Individuals...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What is the scope and purpose of the NIH Clinical..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.1 What is the scope and purpose of the NIH...

  16. 42 CFR 68a.1 - What is the scope and purpose of the NIH Clinical Research Loan Repayment Program for Individuals...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What is the scope and purpose of the NIH Clinical..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.1 What is the scope and purpose of the NIH...

  17. Educational Research in the United States: A Survey of Pre-K-12 Teachers' Perceptions Regarding the Purpose, Conceptions, Use, Impact, and Dissemination

    ERIC Educational Resources Information Center

    Mahoney, Shawn

    2013-01-01

    The purpose of this survey study was to collect data from pre-K-12 educators in the U.S. regarding their perceptions of the purpose, conceptions, use, impact, and results of educational research. The survey tool was based on existing questionnaires and case studies in the literature, as well as newly developed items. 3,908 educators in a database…

  18. Data Mining: A Hybrid Methodology for Complex and Dynamic Research

    ERIC Educational Resources Information Center

    Lang, Susan; Baehr, Craig

    2012-01-01

    This article provides an overview of the ways in which data and text mining have potential as research methodologies in composition studies. It introduces data mining in the context of the field of composition studies and discusses ways in which this methodology can complement and extend our existing research practices by blending the best of what…

  19. Adopting the Transformational Leadership Perspective in a Complex Research Environment

    ERIC Educational Resources Information Center

    Atkinson, Timothy N.; Pilgreen, Tom

    2011-01-01

    Transformational Leadership is a popular topic among leadership scholars, but for research administrators, Transformational Leadership might seem like an enigmatic approach given its various contexts. Research administrators might think the transformational approach is only for executives, or that they do not have enough staff to call themselves…

  20. Data Mining: A Hybrid Methodology for Complex and Dynamic Research

    ERIC Educational Resources Information Center

    Lang, Susan; Baehr, Craig

    2012-01-01

    This article provides an overview of the ways in which data and text mining have potential as research methodologies in composition studies. It introduces data mining in the context of the field of composition studies and discusses ways in which this methodology can complement and extend our existing research practices by blending the best of what…

  1. The Challenge of Researching Violent Societies: Navigating Complexities in Ethnography

    ERIC Educational Resources Information Center

    Tshabangu, Icarbord

    2009-01-01

    Through use of a recent study researching democratic education and citizenship in Zimbabwe, this paper examines the methodological dilemmas and challenges faced by an ethnographer, particularly by a research student in a violent context. The article posits a bricolage strategy to navigate some of the dangers and methodological dilemmas inherent so…

  2. Connecting Complex Processes: A Decade of Research on Immigrant Families

    ERIC Educational Resources Information Center

    Glick, Jennifer E.

    2010-01-01

    This review examines research on immigrant families in the United States from the past decade from multiple disciplinary perspectives. This work has used variations on assimilation and acculturation perspectives. In the case of the assimilation perspectives, the focus has largely been on family formation, whereas research using acculturation…

  3. Researching Children, Youth and Religion: Identity, Complexity and Agency

    ERIC Educational Resources Information Center

    Hemming, Peter J.; Madge, Nicola

    2012-01-01

    Research on children, young people and religion is becoming more prevalent following an increased interest in this traditionally under-researched area. However, little discussion has taken place to date on the appropriateness of past frameworks for making sense of children's religious lives. This article calls attention to the issue of religious…

  4. Connecting Complex Processes: A Decade of Research on Immigrant Families

    ERIC Educational Resources Information Center

    Glick, Jennifer E.

    2010-01-01

    This review examines research on immigrant families in the United States from the past decade from multiple disciplinary perspectives. This work has used variations on assimilation and acculturation perspectives. In the case of the assimilation perspectives, the focus has largely been on family formation, whereas research using acculturation…

  5. Research approaches related to phenomenology: negotiating a complex landscape.

    PubMed

    Dowling, Maura; Cooney, Adeline

    2012-01-01

    To provide a comprehensive overview of the many research approaches related to phenomenology and their philosophical underpinnings. Phenomenological research approaches are varied and often difficult to apply appropriately. Some researchers persist in labelling their studies as examples of Heideggerian or Husserlian phenomenology without fully understanding the implications of the underpinning philosophical assumptions. Methodological sources related to phenomenology as a philosophy and phenomenology as a research approach are used to illustrate the range of phenomenological methods and their philosophical underpinnings. The origins of phenomenology are the writings of Husserl and the advancement of his thoughts by Merleau-Ponty, Heidegger, Gadamer and Ricoeur. The importance of fully understanding a methodology and its philosophical underpinnings before using it, or claiming to use it, is emphasised. In addition, the variety of phenomenological research approaches that have evolved over the past 50 years are explored and placed in the context of their philosophical underpinnings. There is no single way to conduct a phenomenological study. There are many approaches from which researchers can choose. This has resulted in a range of labels and often in different descriptions for the same approach. It is essential that researchers planning to use phenomenology are familiar with the many approaches available. This knowledge will help researchers choose the approaches that best suit the aims of their studies.

  6. The Challenge of Researching Violent Societies: Navigating Complexities in Ethnography

    ERIC Educational Resources Information Center

    Tshabangu, Icarbord

    2009-01-01

    Through use of a recent study researching democratic education and citizenship in Zimbabwe, this paper examines the methodological dilemmas and challenges faced by an ethnographer, particularly by a research student in a violent context. The article posits a bricolage strategy to navigate some of the dangers and methodological dilemmas inherent so…

  7. Ethical and Methodological Complexities in Research Involving Sexual Minorities

    ERIC Educational Resources Information Center

    Bettinger, Thomas V.

    2010-01-01

    While there is growing attention to sexual minorities in adult education (AE) and human resource development (HRD) literature, lesbian, gay, bisexual, transgender, and queer (LGBTQ) people have received very little attention in AE or in HRD research. This article captures methodological issues and concerns from LBGTQ-related research from…

  8. Governing Education in a Complex World. Educational Research and Innovation

    ERIC Educational Resources Information Center

    Burns, Tracey, Ed.; Köster, Florian, Ed.

    2016-01-01

    What models of governance are effective in complex education systems? In all systems an increasing number of stakeholders are involved in designing, delivering, and monitoring education. Like our societies, education systems are increasingly diverse regarding students, teachers, and communities, as well as the values and identities we expect…

  9. Structure, Agency, Complexity Theory and Interdisciplinary Research in Education Studies

    ERIC Educational Resources Information Center

    Smith, John A.

    2013-01-01

    This article argues that Education Studies needs to develop its existing interdisciplinarity understanding of structures and agencies by giving greater attention to the modern process theories of self-organisation in the physical, biological, psychological and social sciences, sometimes given the umbrella term "complexity theory". The…

  10. Structure, Agency, Complexity Theory and Interdisciplinary Research in Education Studies

    ERIC Educational Resources Information Center

    Smith, John A.

    2013-01-01

    This article argues that Education Studies needs to develop its existing interdisciplinarity understanding of structures and agencies by giving greater attention to the modern process theories of self-organisation in the physical, biological, psychological and social sciences, sometimes given the umbrella term "complexity theory". The…

  11. Governing Education in a Complex World. Educational Research and Innovation

    ERIC Educational Resources Information Center

    Burns, Tracey, Ed.; Köster, Florian, Ed.

    2016-01-01

    What models of governance are effective in complex education systems? In all systems an increasing number of stakeholders are involved in designing, delivering, and monitoring education. Like our societies, education systems are increasingly diverse regarding students, teachers, and communities, as well as the values and identities we expect…

  12. The Complex Experience of Learning to Do Research

    ERIC Educational Resources Information Center

    Emo, Kenneth; Emo, Wendy; Kimn, Jung-Han; Gent, Stephen

    2015-01-01

    This article examines how student learning is a product of the experiential interaction between person and environment. We draw from the theoretical perspective of complexity to shed light on the emergent, adaptive, and unpredictable nature of students' learning experiences. To understand the relationship between the environment and the student…

  13. The Complex Experience of Learning to Do Research

    ERIC Educational Resources Information Center

    Emo, Kenneth; Emo, Wendy; Kimn, Jung-Han; Gent, Stephen

    2015-01-01

    This article examines how student learning is a product of the experiential interaction between person and environment. We draw from the theoretical perspective of complexity to shed light on the emergent, adaptive, and unpredictable nature of students' learning experiences. To understand the relationship between the environment and the student…

  14. Success case studies contribute to evaluation of complex research infrastructure.

    PubMed

    Hogle, Janice A; Moberg, D Paul

    2014-03-01

    The success case studies approach examines in depth what works well in a program by describing cases and examining factors leading to successful outcomes. In this article, we describe the use of success case studies as part of an evaluation of the transformation of a health sciences research support infrastructure. Using project-specific descriptions and the researchers' perceptions of the impact of improved research infrastructure, we added depth of understanding to the quantitative data required by funding agencies. Each case study included an interview with the lead researcher, along with review of documents about the research, the investigator, and their collaborators. Our analyses elucidated themes regarding contributions of the Clinical and Translational Science Awards program of the National Institutes of Health to scientific achievements and career advancement of investigators in one academic institution.

  15. Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.

    PubMed

    Stec, Wojciech J; Rosiak, Kamila; Siejka, Paulina; Peciak, Joanna; Popeda, Marta; Banaszczyk, Mateusz; Pawlowska, Roza; Treda, Cezary; Hulas-Bigoszewska, Krystyna; Piaskowski, Sylwester; Stoczynska-Fidelus, Ewelina; Rieske, Piotr

    2016-05-31

    Glioblastoma is the most common and malignant brain tumor, characterized by high cellular heterogeneity. About 50% of glioblastomas are positive for EGFR amplification, half of which express accompanying EGFR mutation, encoding truncated and constitutively active receptor termed EGFRvIII. Currently, no cell models suitable for development of EGFRvIII-targeting drugs exist, while the available ones lack the intratumoral heterogeneity or extrachromosomal nature of EGFRvIII.The reports regarding the biology of EGFRvIII expressed in the stable cell lines are often contradictory in observations and conclusions. In the present study, we use DK-MG cell line carrying endogenous non-modified EGFRvIII amplicons and derive a sub-line that is near depleted of amplicons, whilst remaining identical on the chromosomal level. By direct comparison of the two lines, we demonstrate positive effects of EGFRvIII on cell invasiveness and populational growth as a result of elevated cell survival but not proliferation rate. Investigation of the PI3K/Akt indicated no differences between the lines, whilst NFκB pathway was over-active in the line strongly expressing EGFRvIII, finding further supported by the effects of NFκB pathway specific inhibitors. Taken together, these results confirm the important role of EGFRvIII in intrinsic and extrinsic regulation of tumor behavior. Moreover, the proposed models are stable, making them suitable for research purposes as well as drug development process utilizing high throughput approach.

  16. Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes.

    PubMed

    Metcalf, J S; Meriluoto, J A O; Codd, G A

    2006-05-25

    Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guidelines and regulations governing their production, storage, packaging and transportation. In all of these respects, cyanotoxins are coming under the types of controls imposed on a wide range of chemicals and other biotoxins of microbial, plant and animal origin. These controls apply whether cyanotoxins are supplied on a commercial basis, or stored and transported in non-commercial research collaborations and programmes. Included are requirements concerning the transportation of these toxins as documented by the United Nations, the International Air Transport Association (IATA) and national government regulations. The transportation regulations for "dangerous goods", which by definition include cyanotoxins, cover air mail, air freight, and goods checked in and carried on flights. Substances include those of determined toxicity and others of suspected or undetermined toxicity, covering purified cyanotoxins, cyanotoxin-producing laboratory strains and environmental samples of cyanobacteria. Implications of the regulations for the packaging and air-transport of dangerous goods, as they apply to cyanotoxins and toxigenic cyanobacteria, are discussed.

  17. Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes

    PubMed Central

    Stec, Wojciech J.; Rosiak, Kamila; Siejka, Paulina; Peciak, Joanna; Popeda, Marta; Banaszczyk, Mateusz; Pawlowska, Roza; Treda, Cezary; Hulas-Bigoszewska, Krystyna; Piaskowski, Sylwester; Stoczynska-Fidelus, Ewelina; Rieske, Piotr

    2016-01-01

    Glioblastoma is the most common and malignant brain tumor, characterized by high cellular heterogeneity. About 50% of glioblastomas are positive for EGFR amplification, half of which express accompanying EGFR mutation, encoding truncated and constitutively active receptor termed EGFRvIII. Currently, no cell models suitable for development of EGFRvIII-targeting drugs exist, while the available ones lack the intratumoral heterogeneity or extrachromosomal nature of EGFRvIII. The reports regarding the biology of EGFRvIII expressed in the stable cell lines are often contradictory in observations and conclusions. In the present study, we use DK-MG cell line carrying endogenous non-modified EGFRvIII amplicons and derive a sub-line that is near depleted of amplicons, whilst remaining identical on the chromosomal level. By direct comparison of the two lines, we demonstrate positive effects of EGFRvIII on cell invasiveness and populational growth as a result of elevated cell survival but not proliferation rate. Investigation of the PI3K/Akt indicated no differences between the lines, whilst NFκB pathway was over-active in the line strongly expressing EGFRvIII, finding further supported by the effects of NFκB pathway specific inhibitors. Taken together, these results confirm the important role of EGFRvIII in intrinsic and extrinsic regulation of tumor behavior. Moreover, the proposed models are stable, making them suitable for research purposes as well as drug development process utilizing high throughput approach. PMID:27004406

  18. Research on recognition methods of aphid objects in complex backgrounds

    NASA Astrophysics Data System (ADS)

    Zhao, Hui-Yan; Zhang, Ji-Hong

    2009-07-01

    In order to improve the recognition accuracy among the kinds of aphids in the complex backgrounds, the recognition method among kinds of aphids based on Dual-Tree Complex Wavelet Transform (DT-CWT) and Support Vector Machine (Libsvm) is proposed. Firstly the image is pretreated; secondly the aphid images' texture feature of three crops are extracted by DT-CWT in order to get the training parameters of training model; finally the training model could recognize aphids among the three kinds of crops. By contrasting to Gabor wavelet transform and the traditional extracting texture's methods based on Gray-Level Co-Occurrence Matrix (GLCM), the experiment result shows that the method has a certain practicality and feasibility and provides basic for aphids' recognition between the identification among same kind aphid.

  19. Extending the Theoretical Framing for Physics Education Research: An Illustrative Application of Complexity Science

    ERIC Educational Resources Information Center

    Forsman, Jonas; Moll, Rachel; Linder, Cedric

    2014-01-01

    The viability of using complexity science in physics education research (PER) is exemplified by (1) situating central tenets of student persistence research in complexity science and (2) drawing on the methods that become available from this to illustrate analyzing the structural aspects of students' networked interactions as an important dynamic…

  20. Extending the Theoretical Framing for Physics Education Research: An Illustrative Application of Complexity Science

    ERIC Educational Resources Information Center

    Forsman, Jonas; Moll, Rachel; Linder, Cedric

    2014-01-01

    The viability of using complexity science in physics education research (PER) is exemplified by (1) situating central tenets of student persistence research in complexity science and (2) drawing on the methods that become available from this to illustrate analyzing the structural aspects of students' networked interactions as an important dynamic…

  1. Research on complex turbulent flows at the UW (overall effort)

    NASA Technical Reports Server (NTRS)

    Gessner, F. B.

    1987-01-01

    Development of a pressure-strain model, an algebraic stress model, and wall functions appropriate for flows with spanwise variations in the local wall shear stress are accomplished. Furthermore, a hot-wire measurement technique was also developed for determining the local mean velocity and Reynolds stresses in a complex flow. Experiments were performed on supersonic and subsonic turbulent flow in a square duct, flow about a strut-endwall, flow within a transition duct, and on co-flowing annular jets with swirl. All results are presented in a viewgraph format.

  2. Service-Learning Research: Definitional Challenges and Complexities

    ERIC Educational Resources Information Center

    Chong, Cho See

    2014-01-01

    This article highlights some of the challenges a researcher has to confront when conducting a study on the impacts of service-learning. A review of the literature has revealed that the term "service-learning" has been variously defined and is often misunderstood. This confusion is exacerbated by the inconsistencies in the way…

  3. What Research Says about Text Complexity and Learning to Read

    ERIC Educational Resources Information Center

    Allington, Richard L.; McCuiston, Kimberly; Billen, Monica

    2015-01-01

    The CCSS framework indicates more difficult texts are to be used with students. However, the rationale for increasing text difficulty, decreasing text difficulty, is unsupported by the research that shows texts have been increasing in difficulty for at least 50 years. Oral reading accuracy is a traditional method of estimating text difficulty. For…

  4. What Research Says about Text Complexity and Learning to Read

    ERIC Educational Resources Information Center

    Allington, Richard L.; McCuiston, Kimberly; Billen, Monica

    2015-01-01

    The CCSS framework indicates more difficult texts are to be used with students. However, the rationale for increasing text difficulty, decreasing text difficulty, is unsupported by the research that shows texts have been increasing in difficulty for at least 50 years. Oral reading accuracy is a traditional method of estimating text difficulty. For…

  5. Participatory Action Research in Culturally Complex Societies: Opportunities and Challenges

    ERIC Educational Resources Information Center

    Balakrishnan, Vishalache; Claiborne, Lise

    2017-01-01

    One of the aims of participatory action research (PAR) is to bring realities of lives closer together through dialogue and "conscientization," raising critical awareness among participants from all backgrounds. Promoting participation often assumes a power shift from the decision-makers to the majority of society, who can be the…

  6. A multiscale modelling methodology applicable for regulatory purposes taking into account effects of complex terrain and buildings on pollutant dispersion: a case study for an inner Alpine basin.

    PubMed

    Oettl, D

    2015-11-01

    Dispersion modelling in complex terrain always has been challenging for modellers. Although a large number of publications are dedicated to that field, candidate methods and models for usage in regulatory applications are scarce. This is all the more true when the combined effect of topography and obstacles on pollutant dispersion has to be taken into account. In Austria, largely situated in Alpine regions, such complex situations are quite frequent. This work deals with an approach, which is in principle capable of considering both buildings and topography in simulations by combining state-of-the-art wind field models at the micro- (<1 km) and mesoscale γ (2-20 km) with a Lagrangian particle model. In order to make such complex numerical models applicable for regulatory purposes, meteorological input data for the models need to be readily derived from routine observations. Here, use was made of the traditional way to bin meteorological data based on wind direction, speed, and stability class, formerly mainly used in conjunction with Gaussian-type models. It is demonstrated that this approach leads to reasonable agreements (fractional bias < 0.1) between observed and modelled annual average concentrations in an Alpine basin with frequent low-wind-speed conditions, temperature inversions, and quite complex flow patterns, while keeping the simulation times within the frame of possibility with regard to applications in licencing procedures. However, due to the simplifications in the derivation of meteorological input data as well as several ad hoc assumptions regarding the boundary conditions of the mesoscale wind field model, the methodology is not suited for computing detailed time and space variations of pollutant concentrations.

  7. Research approaches to mass casualty incidents response: development from routine perspectives to complexity science.

    PubMed

    Shen, Weifeng; Jiang, Libing; Zhang, Mao; Ma, Yuefeng; Jiang, Guanyu; He, Xiaojun

    2014-01-01

    To review the research methods of mass casualty incident (MCI) systematically and introduce the concept and characteristics of complexity science and artificial system, computational experiments and parallel execution (ACP) method. We searched PubMed, Web of Knowledge, China Wanfang and China Biology Medicine (CBM) databases for relevant studies. Searches were performed without year or language restrictions and used the combinations of the following key words: "mass casualty incident", "MCI", "research method", "complexity science", "ACP", "approach", "science", "model", "system" and "response". Articles were searched using the above keywords and only those involving the research methods of mass casualty incident (MCI) were enrolled. Research methods of MCI have increased markedly over the past few decades. For now, dominating research methods of MCI are theory-based approach, empirical approach, evidence-based science, mathematical modeling and computer simulation, simulation experiment, experimental methods, scenario approach and complexity science. This article provides an overview of the development of research methodology for MCI. The progresses of routine research approaches and complexity science are briefly presented in this paper. Furthermore, the authors conclude that the reductionism underlying the exact science is not suitable for MCI complex systems. And the only feasible alternative is complexity science. Finally, this summary is followed by a review that ACP method combining artificial systems, computational experiments and parallel execution provides a new idea to address researches for complex MCI.

  8. Using low-frequency IR spectra for the unambiguous identification of metal ion-ligand coordination sites in purpose-built complexes

    NASA Astrophysics Data System (ADS)

    Varga, Gábor; Csendes, Zita; Peintler, Gábor; Berkesi, Ottó; Sipos, Pál; Pálinkó, István

    2014-03-01

    One of the aims of our long-term research is the identification of metal ion-ligand coordination sites in bioinspired metal ion-C- or N-protected amino acid (histidine, tyrosine, cysteine or cystine) complexes immobilised on the surface of chloropropylated silica gel or Merrifield resin. In an attempt to reach this goal, structurally related, but much simpler complexes have been prepared and their metal ion-ligand vibrations were determined from their low-frequency IR spectra. The central ions were Mn(II), Co(II), Ni(II) or Cu(II) and the ligands (imidazole, isopropylamine, monosodium malonate) were chosen to possess only one-type of potential donor group. The low-frequency IR spectra were taken of the complexes for each ion-ligand combination and the typical metal ion-functional group vibration bands were selected and identified. The usefulness of the obtained assignments is demonstrated on exemplary immobilised metal ion-protected amino acid complexes.

  9. Researching a local heroin market as a complex adaptive system.

    PubMed

    Hoffer, Lee D; Bobashev, Georgiy; Morris, Robert J

    2009-12-01

    This project applies agent-based modeling (ABM) techniques to better understand the operation, organization, and structure of a local heroin market. The simulation detailed was developed using data from an 18-month ethnographic case study. The original research, collected in Denver, CO during the 1990s, represents the historic account of users and dealers who operated in the Larimer area heroin market. Working together, the authors studied the behaviors of customers, private dealers, street-sellers, brokers, and the police, reflecting the core elements pertaining to how the market operated. After evaluating the logical consistency between the data and agent behaviors, simulations scaled-up interactions to observe their aggregated outcomes. While the concept and findings from this study remain experimental, these methods represent a novel way in which to understand illicit drug markets and the dynamic adaptations and outcomes they generate. Extensions of this research perspective, as well as its strengths and limitations, are discussed.

  10. 1992 annual report on scientific programs: A broad research program on the sciences of complexity

    SciTech Connect

    Not Available

    1992-12-31

    In 1992 the Santa Fe Institute hosted more than 100 short- and long-term research visitors who conducted a total of 212 person-months of residential research in complex systems. To date this 1992 work has resulted in more than 50 SFI Working Papers and nearly 150 publications in the scientific literature. The Institute`s book series in the sciences of complexity continues to grow, now numbering more than 20 volumes. The fifth annual complex systems summer school brought nearly 60 graduate students and postdoctoral fellows to Santa Fe for an intensive introduction to the field. Research on complex systems-the focus of work at SFI-involves an extraordinary range of topics normally studied in seemingly disparate fields. Natural systems displaying complex adaptive behavior range upwards from DNA through cells and evolutionary systems to human societies. Research models exhibiting complex behavior include spin glasses, cellular automata, and genetic algorithms. Some of the major questions facing complex systems researchers are: (1) explaining how complexity arises from the nonlinear interaction of simple components; (2) describing the mechanisms underlying high-level aggregate behavior of complex systems (such as the overt behavior of an organism, the flow of energy in an ecology, the GNP of an economy); and (3) creating a theoretical framework to enable predictions about the likely behavior of such systems in various conditions.

  11. The 1992 annual report on scientific programs: A broad research program on the sciences of complexity

    NASA Astrophysics Data System (ADS)

    In 1992 the Santa Fe Institute hosted more than 100 short- and long-term research visitors who conducted a total of 212 person-months of residential research in complex systems. To date this 1992 work has resulted in more than 50 SFI Working Papers and nearly 150 publications in the scientific literature. The Institute's book series in the sciences of complexity continues to grow, now numbering more than 20 volumes. The fifth annual complex systems summer school brought nearly 60 graduate students and postdoctoral fellows to Santa Fe for an intensive introduction to the field. Research on complex systems - the focus of work at SFI - involves an extraordinary range of topics normally studied in seemingly disparate fields. Natural systems displaying complex adaptive behavior range upwards from DNA through cells and evolutionary systems to human societies. Research models exhibiting complex behavior include spin glasses, cellular automata, and genetic algorithms. Some of the major questions facing complex systems researchers are: (1) explaining how complexity arises from the nonlinear interaction of simple components; (2) describing the mechanisms underlying high-level aggregate behavior of complex systems (such as the overt behavior of an organism, the flow of energy in an ecology, and the Gross National Product (GNP) of an economy); and (3) creating a theoretical framework to enable predictions about the likely behavior of such systems in various conditions.

  12. Self-Contained Training Materials for Teacher Education: A Derivation from Research on the Learning of Complex Skills. Acquiring Teaching Competencies. Reports and Studies. Report No. 5.

    ERIC Educational Resources Information Center

    Hudgins, Bryce B.

    The purpose of this paper is to select from among the bodies of research on complex skill learning those generalizations that seem to have some applicability to issues in designing training materials for teacher education. That selection entails a review of the principal points and findings within the domain and of the implications of the findings…

  13. Dynamics of Research Team Formation in Complex Networks

    NASA Astrophysics Data System (ADS)

    Sun, Caihong; Wan, Yuzi; Chen, Yu

    Most organizations encourage the formation of teams to accomplish complicated tasks, and vice verse, effective teams could bring lots benefits and profits for organizations. Network structure plays an important role in forming teams. In this paper, we specifically study the dynamics of team formation in large research communities in which knowledge of individuals plays an important role on team performance and individual utility. An agent-based model is proposed, in which heterogeneous agents from research communities are described and empirically tested. Each agent has a knowledge endowment and a preference for both income and leisure. Agents provide a variable input (‘effort’) and their knowledge endowments to production. They could learn from others in their team and those who are not in their team but have private connections in community to adjust their own knowledge endowment. They are allowed to join other teams or work alone when it is welfare maximizing to do so. Various simulation experiments are conducted to examine the impacts of network topology, knowledge diffusion among community network, and team output sharing mechanisms on the dynamics of team formation.

  14. Developing theory from complexity: reflections on a collaborative mixed method participatory action research study.

    PubMed

    Westhues, Anne; Ochocka, Joanna; Jacobson, Nora; Simich, Laura; Maiter, Sarah; Janzen, Rich; Fleras, Augie

    2008-05-01

    Research studies are increasingly complex: They draw on multiple methods to gather data, generate both qualitative and quantitative data, and frequently represent the perspectives of more than one stakeholder. The teams that generate them are increasingly multidisciplinary. A commitment to engaging community members in the research process often adds a further layer of complexity. How to approach a synthesizing analysis of these multiple and varied data sources with a large research team requires considerable reflection and dialogue. In this article, we outline the strategies used by one multidisciplinary team committed to a participatory action research (PAR) approach and engaged in a mixed method program of research to synthesize the findings from four subprojects into a conceptual framework that could guide practice in community mental health organizations. We also summarize factors that hold promise for increasing productivity when managing complex research projects.

  15. Complex research of the areas of the Moon gravity anomalies.

    NASA Astrophysics Data System (ADS)

    Pugacheva, Svetlana

    The report presents the results of a research study of the lunar surface in the areas of gravity anomalies. The source of gravity anomalies of the Moon are large mascons with a high mass concentration at a depth of volcanic plains and lunar Maria. Formation of mascons is connected with intensive development of basaltic volcanism on the Moon in the early periods of its existence. Many volcanic structures have been found by the Grail spacecraft. These are tectonic structures, basins of impact craters, ancient linear gravity anomalies. The article presents the data of physical and mechanical properties of the surface soil layer of the lunar Maria and gives an assessment of the chemical composition of the soil. All measurements have been performed according to the theoretical models of light scattering on the basis of survey of the lunar surface by in-orbit spacecrafts and analysis of the lunar soil samples. There have been calculated heterogeneity parameters of the surface macro-relief of the lunar Maria: albedo, soil density, average grain diameter of the particles forming the surface layer and the volume fraction occupied by particles. Previous articles showed correlation dependence of the chemical composition of rocks on the macrostructure of the lunar surface. The surface macrostructure was evaluated by comparing the local phase function with the lunar spatial scattering indicatrix. Phase function difference at an 18-degree phase is properly consistent with the chemical composition of the surface layer of soil, in particular with the content of thorium and iron oxide. It can be assumed that mascons include rich KREEP rocks with a high content of thorium and iron oxide. KREEP rocks in the areas of the lunar Maria covered by volcanic lava are probably located on the surface or at a shallow depth.

  16. Conceptualizing Debates in Learning and Educational Research: Toward a Complex Systems Conceptual Framework of Learning

    ERIC Educational Resources Information Center

    Jacobson, Michael J.; Kapur, Manu; Reimann, Peter

    2016-01-01

    This article proposes a conceptual framework of learning based on perspectives and methodologies being employed in the study of complex physical and social systems to inform educational research. We argue that the contexts in which learning occurs are complex systems with elements or agents at different levels--including neuronal, cognitive,…

  17. Challenging the Research Base of the Common Core State Standards: A Historical Reanalysis of Text Complexity

    ERIC Educational Resources Information Center

    Gamson, David A.; Lu, Xiaofei; Eckert, Sarah Anne

    2013-01-01

    The widely adopted Common Core State Standards (CCSS) call for raising the level of text complexity in textbooks and reading materials used by students across all grade levels in the United States; the authors of the English Language Arts component of the CCSS build their case for higher complexity in part upon a research base they say shows a…

  18. Moving alcohol prevention research forward-Part I: introducing a complex systems paradigm.

    PubMed

    Apostolopoulos, Yorghos; Lemke, Michael K; Barry, Adam E; Lich, Kristen Hassmiller

    2017-07-22

    The drinking environment is a complex system consisting of a number of heterogeneous, evolving and interacting components, which exhibit circular causality and emergent properties. These characteristics reduce the efficacy of commonly used research approaches, which typically do not account for the underlying dynamic complexity of alcohol consumption and the interdependent nature of diverse factors influencing misuse over time. We use alcohol misuse among college students in the United States as an example for framing our argument for a complex systems paradigm. A complex systems paradigm, grounded in socio-ecological and complex systems theories and computational modeling and simulation, is introduced. Theoretical, conceptual, methodological and analytical underpinnings of this paradigm are described in the context of college drinking prevention research. The proposed complex systems paradigm can transcend limitations of traditional approaches, thereby fostering new directions in alcohol prevention research. By conceptualizing student alcohol misuse as a complex adaptive system, computational modeling and simulation methodologies and analytical techniques can be used. Moreover, use of participatory model-building approaches to generate simulation models can further increase stakeholder buy-in, understanding and policymaking. A complex systems paradigm for research into alcohol misuse can provide a holistic understanding of the underlying drinking environment and its long-term trajectory, which can elucidate high-leverage preventive interventions. © 2017 Society for the Study of Addiction.

  19. Conceptualizing Debates in Learning and Educational Research: Toward a Complex Systems Conceptual Framework of Learning

    ERIC Educational Resources Information Center

    Jacobson, Michael J.; Kapur, Manu; Reimann, Peter

    2016-01-01

    This article proposes a conceptual framework of learning based on perspectives and methodologies being employed in the study of complex physical and social systems to inform educational research. We argue that the contexts in which learning occurs are complex systems with elements or agents at different levels--including neuronal, cognitive,…

  20. 1991 Annual report on scientific programs: A broad research program on the sciences of complexity

    SciTech Connect

    Not Available

    1991-12-31

    1991 was continued rapid growth for the Santa Fe Institute (SFI) as it broadened its interdisciplinary research into the organization, evolution and operation of complex systems and sought deeply the principles underlying their dynamic behavior. Research on complex systems--the focus of work at SFI--involves an extraordinary range of topics normally studied in seemingly disparate fields. Natural systems displaying complex behavior range upwards from proteins and DNA through cells and evolutionary systems to human societies. Research models exhibiting complexity include nonlinear equations, spin glasses, cellular automata, genetic algorithms, classifier systems, and an array of other computational models. Some of the major questions facing complex systems researchers are: (1) explaining how complexity arises from the nonlinear interaction of simples components, (2) describing the mechanisms underlying high-level aggregate behavior of complex systems (such as the overt behavior of an organism, the flow of energy in an ecology, the GNP of an economy), and (3) creating a theoretical framework to enable predictions about the likely behavior of such systems in various conditions. The importance of understanding such systems in enormous: many of the most serious challenges facing humanity--e.g., environmental sustainability, economic stability, the control of disease--as well as many of the hardest scientific questions--e.g., protein folding, the distinction between self and non-self in the immune system, the nature of intelligence, the origin of life--require deep understanding of complex systems.

  1. 1991 Annual report on scientific programs: A broad research program on the sciences of complexity

    SciTech Connect

    Not Available

    1991-01-01

    1991 was continued rapid growth for the Santa Fe Institute (SFI) as it broadened its interdisciplinary research into the organization, evolution and operation of complex systems and sought deeply the principles underlying their dynamic behavior. Research on complex systems--the focus of work at SFI--involves an extraordinary range of topics normally studied in seemingly disparate fields. Natural systems displaying complex behavior range upwards from proteins and DNA through cells and evolutionary systems to human societies. Research models exhibiting complexity include nonlinear equations, spin glasses, cellular automata, genetic algorithms, classifier systems, and an array of other computational models. Some of the major questions facing complex systems researchers are: (1) explaining how complexity arises from the nonlinear interaction of simples components, (2) describing the mechanisms underlying high-level aggregate behavior of complex systems (such as the overt behavior of an organism, the flow of energy in an ecology, the GNP of an economy), and (3) creating a theoretical framework to enable predictions about the likely behavior of such systems in various conditions. The importance of understanding such systems in enormous: many of the most serious challenges facing humanity--e.g., environmental sustainability, economic stability, the control of disease--as well as many of the hardest scientific questions--e.g., protein folding, the distinction between self and non-self in the immune system, the nature of intelligence, the origin of life--require deep understanding of complex systems.

  2. Challenging the Research Base of the Common Core State Standards: A Historical Reanalysis of Text Complexity

    ERIC Educational Resources Information Center

    Gamson, David A.; Lu, Xiaofei; Eckert, Sarah Anne

    2013-01-01

    The widely adopted Common Core State Standards (CCSS) call for raising the level of text complexity in textbooks and reading materials used by students across all grade levels in the United States; the authors of the English Language Arts component of the CCSS build their case for higher complexity in part upon a research base they say shows a…

  3. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.

    PubMed

    Sahin, Mustafa; Henske, Elizabeth P; Manning, Brendan D; Ess, Kevin C; Bissler, John J; Klann, Eric; Kwiatkowski, David J; Roberds, Steven L; Silva, Alcino J; Hillaire-Clarke, Coryse St; Young, Lisa R; Zervas, Mark; Mamounas, Laura A

    2016-07-01

    On March 10 to March 12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland, to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis (http://www.ninds.nih.gov/about_ninds/plans/tscler_research_plan.htm). In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the National Institutes of Health, the Department of Defense Tuberous Sclerosis Complex Research Program, and a broad cross-section of basic scientists and clinicians with expertise in tuberous sclerosis complex along with representatives from the pharmaceutical industry. Here we summarize the outcomes from the extensive premeeting deliberations and final workshop recommendations, including (1) progress in the field since publication of the initial 2003 research plan for tuberous sclerosis complex, (2) the key gaps, needs, and challenges that hinder progress in tuberous sclerosis complex research, and (3) a new set of research priorities along with specific recommendations for addressing the major challenges in each priority area. The new research plan is organized around both short-term and long-term goals with the expectation that progress toward specific objectives can be achieved within a five to ten year time frame. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations from the 2015 Strategic Planning Conference

    PubMed Central

    Sahin, Mustafa; Henske, Elizabeth P.; Manning, Brendan D.; Ess, Kevin C.; Bissler, John J.; Klann, Eric; Kwiatkowski, David J.; Roberds, Steven L.; Silva, Alcino J.; Hillaire-Clarke, Coryse St.; Young, Lisa R.; Zervas, Mark; Mamounas, Laura A.

    2016-01-01

    On March 10–12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis (http://www.ninds.nih.gov/about_ninds/plans/tscler_research_plan.htm). In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the National Institutes of Health, the Department of Defense Tuberous Sclerosis Complex Research Program and a broad cross-section of basic scientists and clinicians with expertise in tuberous sclerosis complex along with representatives from the pharmaceutical industry. This review summarizes outcomes from the extensive pre-meeting deliberations and final workshop recommendations, and includes: 1) progress in the field since publication of the initial 2003 research plan for tuberous sclerosis complex; 2) the key gaps, needs and challenges that hinder progress in tuberous sclerosis complex research; and 3) a new set of research priorities along with specific recommendations for addressing the major challenges in each priority area. The new research plan is organized around both short-term and long-term goals with the expectation that progress toward specific objectives can be achieved within a five- to ten-year timeframe. PMID:27267556

  5. Research and Development of Manufacture Technology of Polymeric Composite Materials of Electrotechnical Purpose Filled with Hydrolytic Lignin

    NASA Astrophysics Data System (ADS)

    Negmatov, S. S.; Salimsakov, Yu. A.; Sobirov, B. B.; Kobilov, N. S.; Negmatova, K. S.; Rakhmanov, B. Sh.

    2008-08-01

    In work the opportunity of manufacture of polymeric composite materials of electro technical purpose filled hydrolytic lignin from wood, cotton of peel and rice husks were shown in view of changes occurring in hydrolytic lignin of conditions of reception and processing press composition.

  6. The center for plant and microbial complex carbohydrates at The University of Georgia Complex Carbohydrate Research Center (CCRC)

    SciTech Connect

    Albersheim, P.; Darvill, A.

    1990-06-01

    The Complex Carbohydrate research Center (CCRC) has about 90 faculty, staff, postdoctoral research associates, and graduate students. The center grant funds are used to support training of graduate students, collaborative carbohydrate research projects with other institutions, service, and equipment maintenance. The subjects extend from oligosaccharides that protect plants against viruses to oligosaccharides that induce explants to flower, from receptors for oligosaccharides that elicit phytoalexins to oligosaccharides that regulate cation transport across plasma membranes, from the structures of pectic and hemicellulosic polysaccharides to the ability of pathogenesis-related enzymes to release phytoalexin elicitors from fungal cell walls, from the cloning of carbohydrate-degrading enzymes to the cloning of glycanase inhibitors, from the identification of oligosaccharides that kill plant cells to the cloning of receptors that perceive those oligosaccharides that inhibit root formation and stimulate flower formation, from characterization of bacterial polysaccharides that have useful physical characteristics to characterization of complex carbohydrates involved in Rhizobium symbioses, and from developing analytical methods to purify and characterize carbohydrates to the development of computer methods to reduce the need to structurally characterize carbohydrates. The CCRC's progress in collaborative research, training, and service is summarized in the appendices accompanying this report.

  7. Ethical aspects of informed consent for the collection, preservation and use of cells and tissues in biological banks for research purposes.

    PubMed

    Petrini, Carlo

    2012-01-01

    This article explores the current and proposed requirements for informed consent for research with biological samples. The establishment of biobanks and the capabilities of collecting, storing, and using cells and tissues for research purposes have noticeably grown. With new abilities come new challenges to ethical questions of consent, specifically concerning genetic information, and unanticipated usage. This paper summarizes these issues in the context of levels of informed consent, subject risk, individual vs. societal benefits, anonymity, legal consensus.

  8. Joint Research Centre Copernicus Climate Change Service (C3S) Fitness-for-Purpose (F4P) Platform

    NASA Astrophysics Data System (ADS)

    Gobron, N.; Adams, J. S.; Cappucci, F.; Lanconelli, C.; Mota, B.; Melin, F.

    2016-08-01

    This paper presents the concept and first results of the Copernicus Climate Change Service Fitness-for-Purpose (C3S F4P) project. The main goal aims at evaluating the efficiency and overall performance of the service, mainly with regard to users information needs and high level requirements. This project will also assess the fitness- for-purpose of the C3S with a specific emphasis on the needs of European Union (EU) Policies and translate these recommendations into programmatic and technical requirements. The C3S Climate Data Records (CDS) include various Essential Climate Variables (ECVs) that are derived from space sensors, including from Copernicus Sentinels sensors. One module of the F4P platform focuses on the benchmarking of data sets and algorithms, in addition to radiative transfer models used towards understanding potential discrepancies between CDS records. Methods and preliminary results of the benchmark platform are presented in this contribution.

  9. 26 CFR 301.6103(l)(2)-2 - Disclosure of returns and return information to Department of Labor for purposes of research and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Department of Labor for purposes of research and studies. 301.6103(l)(2)-2 Section 301.6103(l)(2)-2 Internal... PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6103(l)(2)-2 Disclosure of... rule. Pursuant to the provisions of section 6103(l)(2) of the Internal Revenue Code and subject to...

  10. 26 CFR 301.6103(l)(2)-2 - Disclosure of returns and return information to Department of Labor for purposes of research and...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Department of Labor for purposes of research and studies. 301.6103(l)(2)-2 Section 301.6103(l)(2)-2 Internal... PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6103(l)(2)-2 Disclosure of... rule. Pursuant to the provisions of section 6103(l)(2) of the Internal Revenue Code and subject to the...

  11. 26 CFR 301.6103(l)(2)-2 - Disclosure of returns and return information to Department of Labor for purposes of research and...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Department of Labor for purposes of research and studies. 301.6103(l)(2)-2 Section 301.6103(l)(2)-2 Internal... PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6103(l)(2)-2 Disclosure of... rule. Pursuant to the provisions of section 6103(l)(2) of the Internal Revenue Code and subject to the...

  12. 26 CFR 301.6103(l)(2)-2 - Disclosure of returns and return information to Department of Labor for purposes of research and...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Department of Labor for purposes of research and studies. 301.6103(l)(2)-2 Section 301.6103(l)(2)-2 Internal... PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6103(l)(2)-2 Disclosure of... rule. Pursuant to the provisions of section 6103(l)(2) of the Internal Revenue Code and subject to the...

  13. 26 CFR 301.6103(l)(2)-2 - Disclosure of returns and return information to Department of Labor for purposes of research and...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Department of Labor for purposes of research and studies. 301.6103(l)(2)-2 Section 301.6103(l)(2)-2 Internal... PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6103(l)(2)-2 Disclosure of... rule. Pursuant to the provisions of section 6103(l)(2) of the Internal Revenue Code and subject to the...

  14. [Research on nursing in light of Edgar Morin's concept of complexity].

    PubMed

    Santos, Silvana Sidney Costa

    2003-01-01

    This paper aims at introducing Complexity by showing its importance through research carried out in the Nursing area. It consists of a reflection divided into two parts: the Complexity's principles, by Edgar Morin; and research on Nursing originating from Complexity. By taking into account the Complexity involving the objects of study in Nursing, it is desirable to choose a methodological path which is more appropriate to its comprehension, that is, to choose only one method which is more likely to portray a real picture of the subject. By understanding such method as a path to investigation combined with and originating from theory and not as a support to scientific practice, the concept of Complexity, by Edgar Morin, when used as a theoretical choice, ends up as a guide to a methodological path.

  15. Quantitative Research Methods in Chaos and Complexity: From Probability to Post Hoc Regression Analyses

    ERIC Educational Resources Information Center

    Gilstrap, Donald L.

    2013-01-01

    In addition to qualitative methods presented in chaos and complexity theories in educational research, this article addresses quantitative methods that may show potential for future research studies. Although much in the social and behavioral sciences literature has focused on computer simulations, this article explores current chaos and…

  16. The Complex Learning Difficulties and Disabilities Research Project: Developing Meaningful Pathways to Personalised Learning. Final Report

    ERIC Educational Resources Information Center

    Schools Network, 2011

    2011-01-01

    The Specialist Schools and Academies Trust (SSAT) was commissioned by the Department for Education (DfE) to research ways to improve outcomes for children and young people with the most complex educational needs and disabilities through the development of evidence-based teaching and learning strategies. The programme of research brought together a…

  17. Bifurcation and Hysteresis Effects in Student Performance: The Signature of Complexity and Chaos in Educational Research

    ERIC Educational Resources Information Center

    Stamovlasis, Dimitrios

    2014-01-01

    This paper addresses some methodological issues concerning traditional linear approaches and shows the need for a paradigm shift in education research towards the Complexity and Nonlinear Dynamical Systems (NDS) framework. It presents a quantitative piece of research aiming to test the nonlinear dynamical hypothesis in education. It applies…

  18. The Complex Learning Difficulties and Disabilities Research Project: Developing Meaningful Pathways to Personalised Learning. Executive Summary

    ERIC Educational Resources Information Center

    Schools Network, 2011

    2011-01-01

    The Specialist Schools and Academies Trust (SSAT) was commissioned by the Department for Education (DfE) to research ways to improve outcomes for children and young people with the most complex educational needs and disabilities through the development of evidence-based teaching and learning strategies. The programme of research brought together a…

  19. 1993 Annual report on scientific programs: A broad research program on the sciences of complexity

    SciTech Connect

    1993-12-31

    This report provides a summary of many of the research projects completed by the Santa Fe Institute (SFI) during 1993. These research efforts continue to focus on two general areas: the study of, and search for, underlying scientific principles governing complex adaptive systems, and the exploration of new theories of computation that incorporate natural mechanisms of adaptation (mutation, genetics, evolution).

  20. Plenary Speech: Researching Complex Dynamic Systems--"Retrodictive Qualitative Modelling" in the Language Classroom

    ERIC Educational Resources Information Center

    Dörnyei, Zoltán

    2014-01-01

    While approaching second language acquisition from a complex dynamic systems perspective makes a lot of intuitive sense, it is difficult for a number of reasons to operationalise such a dynamic approach in research terms. For example, the most common research paradigms in the social sciences tend to examine variables in relative isolation rather…

  1. What We Learned about Mentoring Research Assistants Employed in a Complex, Mixed-Methods Health Study

    ERIC Educational Resources Information Center

    Weeks, Lori E.; Villeneuve, Michelle A.; Hutchinson, Susan; Roger, Kerstin; Versnel, Joan; Packer, Tanya

    2015-01-01

    We investigated the experiences of research assistants in their dual role as both employees and trainees, when they were employed in a complex, mixed-methods, Canadian study on the everyday experience of living with and managing a chronic condition. A total of 13 research assistants participated in one or more components of this study: a survey (n…

  2. Plenary Speech: Researching Complex Dynamic Systems--"Retrodictive Qualitative Modelling" in the Language Classroom

    ERIC Educational Resources Information Center

    Dörnyei, Zoltán

    2014-01-01

    While approaching second language acquisition from a complex dynamic systems perspective makes a lot of intuitive sense, it is difficult for a number of reasons to operationalise such a dynamic approach in research terms. For example, the most common research paradigms in the social sciences tend to examine variables in relative isolation rather…

  3. What qualitative research can contribute to a randomized controlled trial of a complex community intervention.

    PubMed

    Nelson, Geoffrey; Macnaughton, Eric; Goering, Paula

    2015-11-01

    Using the case of a large-scale, multi-site Canadian Housing First research demonstration project for homeless people with mental illness, At Home/Chez Soi, we illustrate the value of qualitative methods in a randomized controlled trial (RCT) of a complex community intervention. We argue that quantitative RCT research can neither capture the complexity nor tell the full story of a complex community intervention. We conceptualize complex community interventions as having multiple phases and dimensions that require both RCT and qualitative research components. Rather than assume that qualitative research and RCTs are incommensurate, a more pragmatic mixed methods approach was used, which included using both qualitative and quantitative methods to understand program implementation and outcomes. At the same time, qualitative research was used to examine aspects of the intervention that could not be understood through the RCT, such as its conception, planning, sustainability, and policy impacts. Through this example, we show how qualitative research can tell a more complete story about complex community interventions. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. How to Successfully Incorporate Undergraduate Researchers Into a Complex Research Program at a Large Institution.

    PubMed

    Weldon, Rebecca B; Reyna, Valerie F

    2015-01-01

    One feature of the Laboratory for Rational Decision Making at Cornell University is the integration of a large number of undergraduate students into a relatively elaborate research program. We describe our thorough screening process, laboratory structure, and our expectations for undergraduate researchers in our lab. We have a structure in place that helps maintain organization and enhance productivity, including scheduled weekly and monthly meetings, and selecting undergraduate and graduate team leaders to lead each research project. We discuss how it is important to encourage students to aim high and have a good attitude toward learning and problem solving. We emphasize that both initiative and teamwork are important in a large research laboratory. We also discuss the importance of giving students responsibility in connection with research projects-our undergraduate researchers engage in data analysis, interpretation of results, and have a high-level understanding of theory.

  5. Putting the Pieces Together: Explore the Idea and Purpose of Developing a Research Agenda for Ed Tech. Leaders Sharing--Research Windows

    ERIC Educational Resources Information Center

    Kadel, Robert

    2005-01-01

    Glen Bull's call for a research agenda for one-to-many computing (page 42 of this issue) raises a larger question: what is the status of a research agenda within education technology? This article first considers what a "research agenda" is in general. The Merriam-Webster dictionary defines research as "studious inquiry or examination." (There's…

  6. Neonatal survival in complex humanitarian emergencies: setting an evidence-based research agenda

    PubMed Central

    2014-01-01

    Background Over 40% of all deaths among children under 5 are neonatal deaths (0–28 days), and this proportion is increasing. In 2012, 2.9 million newborns died, with 99% occurring in low- and middle-income countries. Many of the countries with the highest neonatal mortality rates globally are currently or have recently been affected by complex humanitarian emergencies. Despite the global burden of neonatal morbidity and mortality and risks inherent in complex emergency situations, research investments are not commensurate to burden and little is known about the epidemiology or best practices for neonatal survival in these settings. Methods We used the Child Health and Nutrition Research Initiative (CHNRI) methodology to prioritize research questions on neonatal health in complex humanitarian emergencies. Experts evaluated 35 questions using four criteria (answerability, feasibility, relevance, equity) with three subcomponents per criterion. Using SAS 9.2, a research prioritization score (RPS) and average expert agreement score (AEA) were calculated for each question. Results Twenty-eight experts evaluated all 35 questions. RPS ranged from 0.846 to 0.679 and the AEA ranged from 0.667 to 0.411. The top ten research priorities covered a range of issues but generally fell into two categories– epidemiologic and programmatic components of neonatal health. The highest ranked question in this survey was “What strategies are effective in increasing demand for, and use of skilled attendance?” Conclusions In this study, a diverse group of experts used the CHRNI methodology to systematically identify and determine research priorities for neonatal health and survival in complex humanitarian emergencies. The priorities included the need to better understand the magnitude of the disease burden and interventions to improve neonatal health in complex humanitarian emergencies. The findings from this study will provide guidance to researchers and program implementers in

  7. Development of clinically meaningful complex interventions - the contribution of qualitative research.

    PubMed

    Ludvigsen, Mette Spliid; Meyer, Gabriele; Hall, Elisabeth; Fegran, Liv; Aagaard, Hanne; Uhrenfeldt, Lisbeth

    2013-06-01

    The debate about the "right" methods and designs for nursing research is on-going. According to international surveys, studies on the effectiveness and safety of nursing interventions are rare. Since nursing practice deals daily with interventions, nurses ostensibly expose hospital patients and nursing home residents frequently to unproven therapeutic and preventive nursing interventions. Nursing interventions are predominately of a complex nature, consisting of several components depending on and interacting with each other and their complex contextual factors. Thus, evaluation studies are often challenging and need especially careful development, ambitious designs and systematic evaluations. The UK Medical Research Council (MRC) has proposed a framework, where qualitative and quantitative research rely on each other in order to develop theory-based complex interventions, prepare and conduct their optimal delivery, explain how the interventions work and which conditions contributed in case they did not work. The present essay outlines the points where qualitative research contributes towards the development and evaluation of complex interventions. First, the UK MRC framework is introduced, and secondly it is illustrated where qualitative research should necessarily be located using examples from a handful of qualitative studies. Future clinically meaningful and implementable nursing interventions should best be developed by research groups with both excellent qualitative and quantitative research skills.

  8. Using mixed methods to develop and evaluate complex interventions in palliative care research.

    PubMed

    Farquhar, Morag C; Ewing, Gail; Booth, Sara

    2011-12-01

    there is increasing interest in combining qualitative and quantitative research methods to provide comprehensiveness and greater knowledge yield. Mixed methods are valuable in the development and evaluation of complex interventions. They are therefore particularly valuable in palliative care research where the majority of interventions are complex, and the identification of outcomes particularly challenging. this paper aims to introduce the role of mixed methods in the development and evaluation of complex interventions in palliative care, and how they may be used in palliative care research. the paper defines mixed methods and outlines why and how mixed methods are used to develop and evaluate complex interventions, with a pragmatic focus on design and data collection issues and data analysis. Useful texts are signposted and illustrative examples provided of mixed method studies in palliative care, including a detailed worked example of the development and evaluation of a complex intervention in palliative care for breathlessness. Key challenges to conducting mixed methods in palliative care research are identified in relation to data collection, data integration in analysis, costs and dissemination and how these might be addressed. the development and evaluation of complex interventions in palliative care benefit from the application of mixed methods. Mixed methods enable better understanding of whether and how an intervention works (or does not work) and inform the design of subsequent studies. However, they can be challenging: mixed method studies in palliative care will benefit from working with agreed protocols, multidisciplinary teams and engaging staff with appropriate skill sets.

  9. Interdisciplinarity, Qualitative Research, and the Complex Phenomenon: Toward an Integrative Approach to Intercultural Research

    ERIC Educational Resources Information Center

    Ryan, Phillip; Kurtz, Jill Sornsen; Carter, Deanne; Pester, Danielle

    2014-01-01

    This article is a collaboration by the lead faculty member in a Masters program in Intercultural Studies and students who completed the program under his aegis. This article presents the program's approach to its research course sequence, an approach involving the integration of interdisciplinary and qualitative research. The authors first provide…

  10. PRECISION IN RESEARCH ON COMPLEX LEARNING AND TEACHING--THE MATHEMATICAL FORMULATION OF EDUCATIONAL RESEARCH QUESTIONS.

    ERIC Educational Resources Information Center

    SCANDURA, JOSEPH M.

    THE OBJECTIVE OF THIS RESEARCH WAS TO EXTEND, ELABORATE, AND IMPROVE THE SET-FUNCTION LANGUAGE (SFL). THE SFL IS A NEW SCIENTIFIC LANGUAGE FOR FORMULATING RESEARCH QUESTIONS ON MEANINGFUL LEARNING, FRAMED IN TERMS OF THE MATHEMATICAL NOTIONS OF SETS AND FUNCTIONS. IN THE FIRST PAPER, THE SFL IS DESCRIBED. ITS RELATION TO THE STIMULUS RESPONSE…

  11. Interdisciplinarity, Qualitative Research, and the Complex Phenomenon: Toward an Integrative Approach to Intercultural Research

    ERIC Educational Resources Information Center

    Ryan, Phillip; Kurtz, Jill Sornsen; Carter, Deanne; Pester, Danielle

    2014-01-01

    This article is a collaboration by the lead faculty member in a Masters program in Intercultural Studies and students who completed the program under his aegis. This article presents the program's approach to its research course sequence, an approach involving the integration of interdisciplinary and qualitative research. The authors first provide…

  12. Agency for Healthcare Research and Quality Evidence-based Practice Center methods for systematically reviewing complex multicomponent health care interventions.

    PubMed

    Guise, Jeanne-Marie; Chang, Christine; Viswanathan, Meera; Glick, Susan; Treadwell, Jonathan; Umscheid, Craig A; Whitlock, Evelyn; Fu, Rongwei; Berliner, Elise; Paynter, Robin; Anderson, Johanna; Motu'apuaka, Pua; Trikalinos, Tom

    2014-11-01

    The purpose of this Agency for Healthcare Research and Quality Evidence-based Practice Center methods white paper was to outline approaches to conducting systematic reviews of complex multicomponent health care interventions. We performed a literature scan and conducted semistructured interviews with international experts who conduct research or systematic reviews of complex multicomponent interventions (CMCIs) or organizational leaders who implement CMCIs in health care. Challenges identified include lack of consistent terminology for such interventions (eg, complex, multicomponent, multidimensional, multifactorial); a wide range of approaches used to frame the review, from grouping interventions by common features to using more theoretical approaches; decisions regarding whether and how to quantitatively analyze the interventions, from holistic to individual component analytic approaches; and incomplete and inconsistent reporting of elements critical to understanding the success and impact of multicomponent interventions, such as methods used for implementation the context in which interventions are implemented. We provide a framework for the spectrum of conceptual and analytic approaches to synthesizing studies of multicomponent interventions and an initial list of critical reporting elements for such studies. This information is intended to help systematic reviewers understand the options and tradeoffs available for such reviews. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Complexity.

    PubMed

    Gómez-Hernández, J Jaime

    2006-01-01

    It is difficult to define complexity in modeling. Complexity is often associated with uncertainty since modeling uncertainty is an intrinsically difficult task. However, modeling uncertainty does not require, necessarily, complex models, in the sense of a model requiring an unmanageable number of degrees of freedom to characterize the aquifer. The relationship between complexity, uncertainty, heterogeneity, and stochastic modeling is not simple. Aquifer models should be able to quantify the uncertainty of their predictions, which can be done using stochastic models that produce heterogeneous realizations of aquifer parameters. This is the type of complexity addressed in this article.

  14. General-purpose heat source: Research and development program. Radioisotope thermoelectric generator impact tests: RTG-1 and RTG-2

    SciTech Connect

    Reimus, M.A.H.; Hinckley, J.E.; George, T.G.

    1996-07-01

    The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of {sup 238}Pu decay to an array of thermoelectric elements in a radioisotope thermoelectric generator (RTG). Because the potential for a launch abort or return from orbit exists for any space mission, the heat source response to credible accident scenarios is being evaluated. The first two RTG Impact Tests were designed to provide information on the response of a fully loaded RTG to end-on impact against a concrete target. The results of these tests indicated that at impact velocities up to 57 m/s the converter shell and internal components protect the GPHS capsules from excessive deformation. At higher velocities, some of the internal components of the RTG interact with the GPHS capsules to cause excessive localized deformation and failure.

  15. General-purpose heat source: Research and development program, radioisotope thermoelectric generator/thin fragment impact test

    SciTech Connect

    Reimus, M.A.H.; Hinckley, J.E.

    1996-11-01

    The general-purpose heat source provides power for space missions by transmitting the heat of {sup 238}Pu decay to an array of thermoelectric elements in a radioisotope thermoelectric generator (RTG). Because the potential for a launch abort or return from orbit exists for any space mission, the heat source response to credible accident scenarios is being evaluated. This test was designed to provide information on the response of a loaded RTG to impact by a fragment similar to the type of fragment produced by breakup of the spacecraft propulsion module system. The results of this test indicated that impact by a thin aluminum fragment traveling at 306 m/s may result in significant damage to the converter housing, failure of one fueled clad, and release of a small quantity of fuel.

  16. "Why Are You Doing This?" Questions on Purpose, Structure, and Outcomes in Participatory Action Research Engaging Youth and Teacher Candidates

    ERIC Educational Resources Information Center

    Galletta, Anne; Jones, Vanessa

    2010-01-01

    Our article is based on a study of our integration of social foundations coursework with filmmaking and participatory action research, bringing teacher candidates and middle and high school students together. The project was carried out in partnership between an urban university and two nearby public schools within a Midwestern city known for high…

  17. Model-Based Assessments to Support Learning and Accountability: The Evolution of CRESST's Research on Multiple-Purpose Measures

    ERIC Educational Resources Information Center

    Baker, Eva L.

    2007-01-01

    This article describes the history, evidence warrants, and evolution of the Center for Research on Evaluation, Standards, and Student Testing's (CRESST) model-based assessments. It considers alternative interpretations of scientific or practical models and illustrates how model-based assessment addresses both definitions. The components of the…

  18. Model-Based Assessments to Support Learning and Accountability: The Evolution of CRESST's Research on Multiple-Purpose Measures

    ERIC Educational Resources Information Center

    Baker, Eva L.

    2007-01-01

    This article describes the history, evidence warrants, and evolution of the Center for Research on Evaluation, Standards, and Student Testing's (CRESST) model-based assessments. It considers alternative interpretations of scientific or practical models and illustrates how model-based assessment addresses both definitions. The components of the…

  19. Translating the Theoretical into Practical: A Logical Framework of Functional Analytic Psychotherapy Interactions for Research, Training, and Clinical Purposes

    ERIC Educational Resources Information Center

    Weeks, Cristal E.; Kanter, Jonathan W.; Bonow, Jordan T.; Landes, Sara J.; Busch, Andrew M.

    2012-01-01

    Functional analytic psychotherapy (FAP) provides a behavioral analysis of the psychotherapy relationship that directly applies basic research findings to outpatient psychotherapy settings. Specifically, FAP suggests that a therapist's in vivo (i.e., in-session) contingent responding to targeted client behaviors, particularly positive reinforcement…

  20. Bio-Pedagogical Self-Reflection in PETE: Reawakening the Ethical Conscience and Purpose in Pedagogy and Research

    ERIC Educational Resources Information Center

    Fernandez-Balboa, Juan-Miguel

    2009-01-01

    What guides, in ethical terms, our teaching and research in physical education teacher education (PETE)? This is hard to say, because, by and large, the literature in this field has not addressed this question. To shed some light on this matter, in this paper (a) I analyze some reasons for this lack of analysis; (b) I draw from well-known…

  1. Bio-Pedagogical Self-Reflection in PETE: Reawakening the Ethical Conscience and Purpose in Pedagogy and Research

    ERIC Educational Resources Information Center

    Fernandez-Balboa, Juan-Miguel

    2009-01-01

    What guides, in ethical terms, our teaching and research in physical education teacher education (PETE)? This is hard to say, because, by and large, the literature in this field has not addressed this question. To shed some light on this matter, in this paper (a) I analyze some reasons for this lack of analysis; (b) I draw from well-known…

  2. Translating the Theoretical into Practical: A Logical Framework of Functional Analytic Psychotherapy Interactions for Research, Training, and Clinical Purposes

    ERIC Educational Resources Information Center

    Weeks, Cristal E.; Kanter, Jonathan W.; Bonow, Jordan T.; Landes, Sara J.; Busch, Andrew M.

    2012-01-01

    Functional analytic psychotherapy (FAP) provides a behavioral analysis of the psychotherapy relationship that directly applies basic research findings to outpatient psychotherapy settings. Specifically, FAP suggests that a therapist's in vivo (i.e., in-session) contingent responding to targeted client behaviors, particularly positive reinforcement…

  3. Analyzing Heterogeneous Complexity in Complementary and Alternative Medicine Research: A Systems Biology Solution via Parsimony Phylogenetics

    PubMed Central

    Abu-Asab, Mones; Koithan, Mary; Shaver, Joan; Amri, Hakima

    2012-01-01

    Summary Systems biology offers cutting-edge tools for the study of complementary and alternative medicine (CAM). The advent of ‘omics’ techniques and the resulting avalanche of scientific data have introduced an unprecedented level of complexity and heterogeneous data to biomedical research, leading to the development of novel research approaches. Statistical averaging has its limitations and is unsuitable for the analysis of heterogeneity, as it masks diversity by homogenizing otherwise heterogeneous populations. Unfortunately, most researchers are unaware of alternative methods of analysis capable of accounting for individual variability. This paper describes a systems biology solution to data complexity through the application of parsimony phylogenetic analysis. Maximum parsimony (MP) provides a data-based modeling paradigm that will permit a priori stratification of the study cohort(s), better assessment of early diagnosis, prognosis, and treatment efficacy within each stratum, and a method that could be used to explore, identify and describe complex human patterning. PMID:22327551

  4. New Directions of Research in Complex Plasmas on the International Space Station

    SciTech Connect

    Thomas, H. M.; Morfill, G. E.; Ivlev, A. V.; Hagl, T.; Rothermel, H.; Khrapak, S. A.; Suetterlin, K. R.; Rubin-Zuzic, M.; Schwabe, M.; Zhdanov, S. K.; Raeth, C.; Fortov, V. E.; Molotkov, V. I.; Lipaev, A. M.; Petrov, O. F.; Tokarev, V. I.; Malenchenko, Y. I.; Turin, M. V.; Vinogradov, P. V.; Yurchikhin, F. N.

    2008-09-07

    PK-3 Plus is the second generation laboratory for investigations of complex plasmas under microgravity conditions on the International Space Station. Compared to its pre-cursor PKE-Nefedov, operational 2001-2005, it has an advanced hardware and software. Improved diagnostics and especially a much better homogeneity of the complex plasma allow more detailed investigations, helping to understand the fundamentals of complex plasmas. Typical investigations are performed to observe the structure of homogeneous and isotropic complex plasmas and instabilities occurring at high particle densities. In addition, the new setup allows the tuning of the interaction potential between the microparticles by using external ac electric fields. Thus, we are able to initiate electrorheological phenomena in complex plasma fluids in the PK-3 Plus laboratory, and observe the phase transition from a normal fluid to a string fluid state at the individual particle level for the first time. Such new possibilities open up new directions of research under microgravity conditions.

  5. [Research progress of cell-scaffold complex in tendon tissue engineering].

    PubMed

    Zhu, Ying; Li, Min

    2013-04-01

    To review the research progress of cell-scaffold complex in the tendon tissue engineering. Recent literature concerning cell-scaffold complex in the tendon tissue engineering was reviewed, the research situation of the cell-scaffold complex was elaborated in the aspects of seed cells, scaffolds, cell culture, and application. In tendon tissue engineering, a cell-scaffold complex is built by appropriate seed cells and engineered scaffolds. Experiments showed that modified seed cells had better therapeutic effects. Further, scaffold functionality could be improved through surface modification, growth factor cure, mechanical stimulation, and contact guidance. Among these methods, mechanical stimulation revealed the most significant results in promoting cell proliferation and function. Through a variety of defect models, it is demonstrated that the use of cell-scaffold complex could achieve satisfactory results for tendon regeneration. The cell-scaffold complex for tendon tissue engineering is a popular research topic. Although it has not yet met the requirement of clinical use, it has broad application prospects.

  6. Being scientifical: Popularity, purpose and promotion of amateur research and investigation groups in the U.S

    NASA Astrophysics Data System (ADS)

    Hill, Sharon A.

    21st century television and the Internet are awash in content regarding amateur paranormal investigators and research groups. These groups proliferated after reality investigation programs appeared on television. Exactly how many groups are active in the U.S. at any time is not known. The Internet provides an ideal means for people with niche interests to find each other and organize activities. This study collected information from 1000 websites of amateur research and investigation groups (ARIGs) to determine their location, area of inquiry, methodology and, particularly, to determine if they state that they use science as part of their mission, methods or goals. 57.3% of the ARIGs examined specifically noted or suggested use of science as part of the groups' approach to investigation and research. Even when not explicit, ARIGs often used science-like language, symbols and methods to describe their groups' views or activities. Yet, non-scientific and subjective methods were described as employed in conjunction with objective methods. Furthermore, what were considered scientific processes by ARIGs did not match with established methods and the ethos of the scientific research community or scientific processes of investigation. ARIGs failed to display fundamental understanding regarding objectivity, methodological naturalism, peer review, critical thought and theoretical plausibility. The processes of science appear to be mimicked to present a serious and credible reputation to the non-scientific public. These processes are also actively promoted in the media and directly to the local public as "scientific". These results highlight the gap between the scientific community and the lay public regarding the understanding of what it means to do science and what criteria are necessary to establish reliable knowledge about the world.

  7. How to make complexity look simple? Conveying ecosystems restoration complexity for socio-economic research and public engagement

    PubMed Central

    Glenk, Klaus; Byg, Anja

    2017-01-01

    Ecosystems degradation represents one of the major global challenges at the present time, threating people’s livelihoods and well-being worldwide. Ecosystem restoration therefore seems no longer an option, but an imperative. Restoration challenges are such that a dialogue has begun on the need to re-shape restoration as a science. A critical aspect of that reshaping process is the acceptance that restoration science and practice needs to be coupled with socio-economic research and public engagement. This inescapably means conveying complex ecosystem’s information in a way that is accessible to the wider public. In this paper we take up this challenge with the ultimate aim of contributing to making a step change in science’s contribution to ecosystems restoration practice. Using peatlands as a paradigmatically complex ecosystem, we put in place a transdisciplinary process to articulate a description of the processes and outcomes of restoration that can be understood widely by the public. We provide evidence of the usefulness of the process and tools in addressing four key challenges relevant to restoration of any complex ecosystem: (1) how to represent restoration outcomes; (2) how to establish a restoration reference; (3) how to cope with varying restoration time-lags and (4) how to define spatial units for restoration. This evidence includes the way the process resulted in the creation of materials that are now being used by restoration practitioners for communication with the public and in other research contexts. Our main contribution is of an epistemological nature: while ecosystem services-based approaches have enhanced the integration of academic disciplines and non-specialist knowledge, this has so far only followed one direction (from the biophysical underpinning to the description of ecosystem services and their appreciation by the public). We propose that it is the mix of approaches and epistemological directions (including from the public to the

  8. How to make complexity look simple? Conveying ecosystems restoration complexity for socio-economic research and public engagement.

    PubMed

    Martin-Ortega, Julia; Glenk, Klaus; Byg, Anja

    2017-01-01

    Ecosystems degradation represents one of the major global challenges at the present time, threating people's livelihoods and well-being worldwide. Ecosystem restoration therefore seems no longer an option, but an imperative. Restoration challenges are such that a dialogue has begun on the need to re-shape restoration as a science. A critical aspect of that reshaping process is the acceptance that restoration science and practice needs to be coupled with socio-economic research and public engagement. This inescapably means conveying complex ecosystem's information in a way that is accessible to the wider public. In this paper we take up this challenge with the ultimate aim of contributing to making a step change in science's contribution to ecosystems restoration practice. Using peatlands as a paradigmatically complex ecosystem, we put in place a transdisciplinary process to articulate a description of the processes and outcomes of restoration that can be understood widely by the public. We provide evidence of the usefulness of the process and tools in addressing four key challenges relevant to restoration of any complex ecosystem: (1) how to represent restoration outcomes; (2) how to establish a restoration reference; (3) how to cope with varying restoration time-lags and (4) how to define spatial units for restoration. This evidence includes the way the process resulted in the creation of materials that are now being used by restoration practitioners for communication with the public and in other research contexts. Our main contribution is of an epistemological nature: while ecosystem services-based approaches have enhanced the integration of academic disciplines and non-specialist knowledge, this has so far only followed one direction (from the biophysical underpinning to the description of ecosystem services and their appreciation by the public). We propose that it is the mix of approaches and epistemological directions (including from the public to the

  9. Taking ethical photos of children for medical and research purposes in low-resource settings: an exploratory qualitative study.

    PubMed

    Devakumar, Delan; Brotherton, Helen; Halbert, Jay; Clarke, Andrew; Prost, Audrey; Hall, Jennifer

    2013-07-09

    Photographs are commonly taken of children in medical and research contexts. With the increased availability of photographs through the internet, it is increasingly important to consider their potential for negative consequences and the nature of any consent obtained. In this research we explore the issues around photography in low-resource settings, in particular concentrating on the challenges in gaining informed consent. Exploratory qualitative study using focus group discussions involving medical doctors and researchers who are currently working or have recently worked in low-resource settings with children. Photographs are a valuable resource but photographers need to be mindful of how they are taken and used. Informed consent is needed when taking photographs but there were a number of problems in doing this, such as different concepts of consent, language and literacy barriers and the ability to understand the information. There was no consensus as to the form that the consent should take. Participants thought that while written consent was preferable, the mode of consent should depend on the situation. Photographs are a valuable but potentially harmful resource, thus informed consent is required but its form may vary by context. We suggest applying a hierarchy of dissemination to gauge how detailed the informed consent should be. Care should be taken not to cause harm, with the rights of the child being the paramount consideration.

  10. Taking ethical photos of children for medical and research purposes in low-resource settings: an exploratory qualitative study

    PubMed Central

    2013-01-01

    Background Photographs are commonly taken of children in medical and research contexts. With the increased availability of photographs through the internet, it is increasingly important to consider their potential for negative consequences and the nature of any consent obtained. In this research we explore the issues around photography in low-resource settings, in particular concentrating on the challenges in gaining informed consent. Methods Exploratory qualitative study using focus group discussions involving medical doctors and researchers who are currently working or have recently worked in low-resource settings with children. Results Photographs are a valuable resource but photographers need to be mindful of how they are taken and used. Informed consent is needed when taking photographs but there were a number of problems in doing this, such as different concepts of consent, language and literacy barriers and the ability to understand the information. There was no consensus as to the form that the consent should take. Participants thought that while written consent was preferable, the mode of consent should depend on the situation. Conclusions Photographs are a valuable but potentially harmful resource, thus informed consent is required but its form may vary by context. We suggest applying a hierarchy of dissemination to gauge how detailed the informed consent should be. Care should be taken not to cause harm, with the rights of the child being the paramount consideration. PMID:23835013

  11. Fine tuning of the digit symbol paired associate recall test for practitioner purposes in clinical and research settings.

    PubMed

    Shuttleworth-Edwards, Ann B

    2002-08-01

    Guidelines are presented to facilitate the use of the WAIS Digit Symbol measure of paired associate recall as a neuropsychological instrument. Currently three formal variants of the test exist with accompanying normative data (the original WAIS-R-NI form; a WAIS-R Short Form; a longer WAIS-III form), providing a potential source of confusion which may limit its application. To circumvent this, the present article critically evaluates: (i) variations in test forms and their advantages; (ii) available norms in terms of age and education, with pointers for more differentiated guidelines in this regard; and (iii) the desirability of incorporating a delayed recall variant of the test. Finally, a synopsis of data is presented that supports the screening potential of Digit Symbol paired associate recall in cases of mild neurocognitive dysfunction. For the purposes of this paper, the term WAIS is used with broad reference to all variations of the original Wechsler Adult Intelligence Scale (1955) upon which they were based, including the WAIS-R (1981) and WAIS-III (1997) updated editions, and the South African WAIS (1969). The terms South African WAIS (South African Wechsler Adult Intelligence Scale), WAIS-R (Wechsler Adult Intelligence Scale - Revised), and WAIS-III (Wechsler Adult Intelligence Scale-III), refer to these specific versions of the test.

  12. A qualitative inquiry into the challenges and complexities of research supervision: viewpoints of postgraduate students and faculty members

    PubMed Central

    YOUSEFI, ALIREZA; BAZRAFKAN, LEILA; YAMANI, NIKOO

    2015-01-01

    Introduction The supervision of academic theses at the Universities of Medical Sciences is one of the most important issues with several challenges. The aim of the present study is to discover the nature of problems and challenges of thesis supervision in Iranian universities of medical sciences. Methods The study was conducted with a qualitative method using conventional content analysis approach. Nineteen faculty members, using purposive sampling, and 11 postgraduate medical sciences students (Ph.D students and residents) were selected on the basis of theoretical sampling. The data were gathered through semi-structured interviews and field observations in Shiraz and Isfahan universities of medical sciences from September 2012 to December 2014. The qualitative content analysis was used with a conventional approach to analyze the data. Results While experiencing the nature of research supervision process, faculties and the students faced some complexities and challenges in the research supervision process. The obtained codes were categorized under 4 themes Based on the characteristics; included “contextual problem”, “role ambiguity in thesis supervision”, “poor reflection in supervision” and “ethical problems”. Conclusion The result of this study revealed that there is a need for more attention to planning and defining the supervisory, and research supervision. Also, improvement of the quality of supervisor and students relationship must be considered behind the research context improvement in research supervisory area. PMID:26269785

  13. A qualitative inquiry into the challenges and complexities of research supervision: viewpoints of postgraduate students and faculty members.

    PubMed

    Yousefi, Alireza; Bazrafkan, Leila; Yamani, Nikoo

    2015-07-01

    The supervision of academic theses at the Universities of Medical Sciences is one of the most important issues with several challenges. The aim of the present study is to discover the nature of problems and challenges of thesis supervision in Iranian universities of medical sciences. The study was conducted with a qualitative method using conventional content analysis approach. Nineteen faculty members, using purposive sampling, and 11 postgraduate medical sciences students (Ph.D students and residents) were selected on the basis of theoretical sampling. The data were gathered through semi-structured interviews and field observations in Shiraz and Isfahan universities of medical sciences from September 2012 to December 2014. The qualitative content analysis was used with a conventional approach to analyze the data. While experiencing the nature of research supervision process, faculties and the students faced some complexities and challenges in the research supervision process. The obtained codes were categorized under 4 themes Based on the characteristics; included "contextual problem", "role ambiguity in thesis supervision", "poor reflection in supervision" and "ethical problems". The result of this study revealed that there is a need for more attention to planning and defining the supervisory, and research supervision. Also, improvement of the quality of supervisor and students relationship must be considered behind the research context improvement in research supervisory area.

  14. Communities of Purpose

    ERIC Educational Resources Information Center

    Stukes, Felesia

    2016-01-01

    Communities of Purpose are commonly known to enact their purposes through social movements, grassroots efforts, semi-formal groups, and through organizations in the voluntary sector. They carry out charitable missions and goals and are often committed to the pursuit of social welfare and social change. In this research, I explain why Communities…

  15. Communities of Purpose

    ERIC Educational Resources Information Center

    Stukes, Felesia

    2016-01-01

    Communities of Purpose are commonly known to enact their purposes through social movements, grassroots efforts, semi-formal groups, and through organizations in the voluntary sector. They carry out charitable missions and goals and are often committed to the pursuit of social welfare and social change. In this research, I explain why Communities…

  16. Complex Geodetic Research in Ukrainian Antarctic Station "Academician Vernadsky" (Years 2002 - 2005, 2013-2014)

    NASA Astrophysics Data System (ADS)

    Tretyak, Kornyliy; Hlotov, Volodymyr; Holubinka, Yuriy; Marusazh, Khrystyna

    2016-06-01

    In this paper is given an information about complex geodetic research in Ukrainian Antarctic station "Academician Vernadsky". Research were carried by Lviv polytechnic scientists, during Antarctic expeditions in years 2002 - 2005, 2013, 2014. Main objectives of the studies were: (a) study of the islands glaciers surface volumes changes in Antarctic archipelago and Antarctic Peninsula using terestrial laser scaning and digital terrestrial stereophotogrammetry survey; (b) investigation of Penola strain tectonic fault, using the results of precise GNSS observations.

  17. Role of stem cell research in therapeutic purpose--a hope for new horizon in medical biotechnology.

    PubMed

    Saxena, Ajit Kumar; Singh, Divya; Gupta, Jyoti

    2010-01-01

    regulation). Efforts are being done to grow both embryonic and adult stem cells using "tissue culture engineering" in vitro. SCs could be used for various therapeutic purposes like Parkinson's patients, Alzheimer's disease & other neurological disorders patients, repairing for damaged heart muscles and for type I diabetes patients as an alternative source of chemotherapy including trauma patients which is not only expensive but lack of side effect too.

  18. Modeling of the mechano-chemical behaviour of the nuclear pore complex: current research and perspectives.

    PubMed

    Garcia, Alberto; Rodriguez Matas, Jose F; Raimondi, Manuela T

    2016-10-10

    Recent evidence suggests that mechanical deformation of the cell nucleus regulates the nuclear import of the transcriptional activators of genes involved in primary physiological cell responses such as stem cell differentiation. In addition, this nuclear mechanosensing response is de-regulated in pathological states, such as cancer and neurodegeneration. One hypothesis that could greatly advance the field is that the deformation of the nuclear envelope activates nuclear pore complexes through a direct mechanical link. The understanding of this possible mechanism for nuclear pore complex stretch-activation entails studying the mechanical connection of this complex to the nuclear envelope at the nanoscale. The nanomechanics of the nuclear pore complex is thus emerging as a novel research field, bridging nanoscience with nanotechnology. This review examines the frontier of research methodologies that are potentially useful for building a computational model of this interaction. This includes, for example, electron tomography to assess the geometrical features of the nuclear pore complex and nanoindentation to estimate its mechanical properties and that of the nuclear envelope. In order to summarize the state-of-the-art and perspectives in the field of NPC nanomechanics, this review covers highly interdisciplinary experimental and theoretical research methodologies pertaining to the fields of physics, chemistry, biology, materials and mechanics.

  19. Modeling of the mechano-chemical behaviour of the nuclear pore complex: current research and perspectives

    PubMed Central

    Rodriguez Matas, Jose F.; Raimondi, Manuela T.

    2016-01-01

    Recent evidence suggests that mechanical deformation of the cell nucleus regulates the nuclear import of the transcriptional activators of genes involved in primary physiological cell responses such as stem cell differentiation. In addition, this nuclear mechanosensing response is de-regulated in pathological states, such as cancer and neurodegeneration. One hypothesis that could greatly advance the field is that the deformation of the nuclear envelope activates nuclear pore complexes through a direct mechanical link. The understanding of this possible mechanism for nuclear pore complex stretch-activation entails studying the mechanical connection of this complex to the nuclear envelope at the nanoscale. The nanomechanics of the nuclear pore complex is thus emerging as a novel research field, bridging nanoscience with nanotechnology. This review examines the frontier of research methodologies that are potentially useful for building a computational model of this interaction. This includes, for example, electron tomography to assess the geometrical features of the nuclear pore complex and nanoindentation to estimate its mechanical properties and that of the nuclear envelope. In order to summarize the state-of-the-art and perspectives in the field of NPC nanomechanics, this review covers highly interdisciplinary experimental and theoretical research methodologies pertaining to the fields of physics, chemistry, biology, materials and mechanics. PMID:27713975

  20. A broad research program on the sciences of complexity: Annual report

    SciTech Connect

    Not Available

    1988-12-20

    1988 was the first full year of operation on the Santa Fe Institute, under multiyear grants from the Department of Energy and the National Science Foundation, with additional major grants from Citicorp, Russell Sage Foundation, and MacArthur Foundation. The research, educational, and publishing program of the Institute developed rapidly, especially in the last half of 1988. All of the seemingly disparate subjects in the program represent examples of complex systems with certain common properties that help define the content of an emerging general science of complexity. Major elements of progress in the SFI program were as follows: Economy; Theoretical Immunology; Global Security; Other Research; Summer School; Publishing Program; and Computer Support. This report describes proposed extensions of the 1988 programs into 1989 as well as proposed new workshops and research programs on complex adaptive systems; complexity, entropy, and the physics of information; 1989 complex systems summer school; evolution of human language; organization and evolution of prehistoric southwestern society; public policy studies; modeling human cognition and emotion; proteins, glasses, and spin glasses; theoretical ecology; and computational learning systems.

  1. Developing self-evaluation skills: a pragmatic research-based approach for complex areas of nursing.

    PubMed

    Hek, Gill

    2003-01-01

    Using a newly established community rehabilitation service as the research context, Gill Hek explores ways in which practitioners pragmatically developed self-evaluation research skills. Within the practice setting, community practitioners learnt how to conduct and analyse interviews with service users, and to develop connected database records that could be used across health and social services. The teaching-learning process and the teacher-learner relationship were used as models for researching in this complex area. The project demonstrated how community rehabilitation teams developed self-evaluation research skills to a point where they were able to reflect critically on the service they were providing. Supported by a research team, they were able to use research skills to analyse the volume and throughput of their service. They were also able to establish what needed to be done next within the challenging environment at the interface of health and social care in the community.

  2. Challenges in Integrating a Complex Systems Computer Simulation in Class: An Educational Design Research

    ERIC Educational Resources Information Center

    Loke, Swee-Kin; Al-Sallami, Hesham S.; Wright, Daniel F. B.; McDonald, Jenny; Jadhav, Sheetal; Duffull, Stephen B.

    2012-01-01

    Complex systems are typically difficult for students to understand and computer simulations offer a promising way forward. However, integrating such simulations into conventional classes presents numerous challenges. Framed within an educational design research, we studied the use of an in-house built simulation of the coagulation network in four…

  3. Exploring the Use of Complexity Theory and Action Research as Frameworks for Curriculum Change

    ERIC Educational Resources Information Center

    Wood, Phil; Butt, Graham

    2014-01-01

    This paper considers the impact of a small-scale action research project which focused on the development of an emergent approach to curriculum making in a general certificate in secondary education course in geography. In this context, we argue that complexity thinking offers a useful theoretical foundation from which to understand the nature of…

  4. When Complexity Theory Meets Critical Realism: A Platform for Research on Initial Teacher Education

    ERIC Educational Resources Information Center

    Cochran-Smith, Marilyn; Ell, Fiona; Grudnoff, Lexie; Ludlow, Larry; Haigh, Mavis; Hill, Mary

    2014-01-01

    Many scholars have concluded that teacher education research needs to take a complex view, resist simplification, and account more fully for teacher education's contexts and processes as well as its impact on teacher candidates' and school students' learning (Cochran-Smith & Zeichner, 2005; Grossman & McDonald, 2008; Opfer & Pedder,…

  5. Challenges in Integrating a Complex Systems Computer Simulation in Class: An Educational Design Research

    ERIC Educational Resources Information Center

    Loke, Swee-Kin; Al-Sallami, Hesham S.; Wright, Daniel F. B.; McDonald, Jenny; Jadhav, Sheetal; Duffull, Stephen B.

    2012-01-01

    Complex systems are typically difficult for students to understand and computer simulations offer a promising way forward. However, integrating such simulations into conventional classes presents numerous challenges. Framed within an educational design research, we studied the use of an in-house built simulation of the coagulation network in four…

  6. Envisioning Complexity: Towards a New Conceptualization of Educational Research for Sustainability

    ERIC Educational Resources Information Center

    Pipere, Anita

    2016-01-01

    This paper aims to present some conceptual insights into the research paradigm of complexity that deals with such problems like sustainability, education, and, more specifically--sustainability education. The transdisciplinary perspective and cognitive approaches of a hermeneutical cycle and semantic waves used in argumentation assist in grasping…

  7. A Complex Systems Framework for Research on Leadership and Organizational Dynamics in Academic Libraries

    ERIC Educational Resources Information Center

    Gilstrap, Donald L.

    2009-01-01

    This article provides a historiographical analysis of major leadership and organizational development theories that have shaped our thinking about how we lead and administrate academic libraries. Drawing from behavioral, cognitive, systems, and complexity theories, this article discusses major theorists and research studies appearing over the past…

  8. Becoming a Bricoleur: Constructing Sculptures to Explore Complex and Troublesome Dimensions in Educational Research

    ERIC Educational Resources Information Center

    Selkrig, Mark Andrew

    2014-01-01

    During a recent research project, it became apparent that the conventional taxonomic, textual and linguistic devices used to develop the narrative of a manuscript would not allow me to make sense, or tell the complex story, of my inquiry. I needed to employ multimodal approaches to grapple with the project related to artists who work in…

  9. Exploring the Use of Complexity Theory and Action Research as Frameworks for Curriculum Change

    ERIC Educational Resources Information Center

    Wood, Phil; Butt, Graham

    2014-01-01

    This paper considers the impact of a small-scale action research project which focused on the development of an emergent approach to curriculum making in a general certificate in secondary education course in geography. In this context, we argue that complexity thinking offers a useful theoretical foundation from which to understand the nature of…

  10. A Complex Systems Framework for Research on Leadership and Organizational Dynamics in Academic Libraries

    ERIC Educational Resources Information Center

    Gilstrap, Donald L.

    2009-01-01

    This article provides a historiographical analysis of major leadership and organizational development theories that have shaped our thinking about how we lead and administrate academic libraries. Drawing from behavioral, cognitive, systems, and complexity theories, this article discusses major theorists and research studies appearing over the past…

  11. Use of Movement Imagery in Neurorehabilitation: Researching Effects of a Complex Intervention

    ERIC Educational Resources Information Center

    Braun, Susy M.; Wade, Derick T.; Beurskens, Anna J. H. M.

    2011-01-01

    Since the beginning of the new millennium, the use of mental practice and movement imagery within several medical professions in rehabilitation and therapy has received an increased attention. Before this introduction in healthcare, the use of movement imagery was mainly researched in sports science. Mental practice is a complex intervention. When…

  12. A Dynamic Ensemble for Second Language Research: Putting Complexity Theory into Practice

    ERIC Educational Resources Information Center

    Hiver, Phil; Al-Hoorie, Ali H.

    2016-01-01

    In this article, we introduce a template of methodological considerations, termed "the dynamic ensemble," for scholars doing or evaluating empirical second language development (SLD) research within a complexity/dynamic systems theory (CDST) framework. Given that CDST principles have yielded significant insight into SLD and have become…

  13. Use of Movement Imagery in Neurorehabilitation: Researching Effects of a Complex Intervention

    ERIC Educational Resources Information Center

    Braun, Susy M.; Wade, Derick T.; Beurskens, Anna J. H. M.

    2011-01-01

    Since the beginning of the new millennium, the use of mental practice and movement imagery within several medical professions in rehabilitation and therapy has received an increased attention. Before this introduction in healthcare, the use of movement imagery was mainly researched in sports science. Mental practice is a complex intervention. When…

  14. A Dynamic Ensemble for Second Language Research: Putting Complexity Theory into Practice

    ERIC Educational Resources Information Center

    Hiver, Phil; Al-Hoorie, Ali H.

    2016-01-01

    In this article, we introduce a template of methodological considerations, termed "the dynamic ensemble," for scholars doing or evaluating empirical second language development (SLD) research within a complexity/dynamic systems theory (CDST) framework. Given that CDST principles have yielded significant insight into SLD and have become…

  15. Diseases of complex etiology in small populations: Ethnic differences and research approaches

    SciTech Connect

    Chakraborty, R.; Szathmary, E.J.E.

    1985-01-01

    These proceedings discuss the papers presented at the conference on the subject of complex diseases and genetics. Some of the papers discussed were on ethnic differences of epidemiology of diseases and research programs on genetics. Role of environment in diseases, genetic variability, diseases of unknown etiology like - multiple sclerosis and population dynamics are briefly discussed.

  16. Envisioning Complexity: Towards a New Conceptualization of Educational Research for Sustainability

    ERIC Educational Resources Information Center

    Pipere, Anita

    2016-01-01

    This paper aims to present some conceptual insights into the research paradigm of complexity that deals with such problems like sustainability, education, and, more specifically--sustainability education. The transdisciplinary perspective and cognitive approaches of a hermeneutical cycle and semantic waves used in argumentation assist in grasping…

  17. A cross-sectional pilot study to investigate patient attitudes and perception regarding the use of real time digital recording of urological procedures for research and teaching purposes

    PubMed Central

    Sharp, Gary; Mazzon, Giorgio; Thilagarajah, Ranjan

    2015-01-01

    Little conclusive evidence exists regarding the best way to educate and evaluate skill acquisition of advanced surgical trainees, despite it being recognised as one of the most important aspects of training. Many laparoscopic trainers have been produced with complex engineering at great cost, but, there seems to be a reluctance to use the most precious entity available to us; the patient. We thus propose the use of real time digital recording of urological procedures for research and teaching purposes. This study was prompted by the lack of literature regarding such issues. A 19 question questionnaire was circulated at a single urology out-patient department (Essex, England) over a 6 month period to evaluate attitudes and perceptions of urological patients on potentially having their procedure digitally recorded for educational and research purposes. 11 patients declined, 187 questionnaires were included in the final analysis. Male patients are more willing to consent than female patients. Older patients resulted to have a higher propensity in being recorded for medical teaching. Greater than 50% believe being recorded is intrusive but the majority do not think privacy is an issue. Lastly, the vast majority require a formal debrief post operatively. Our results show that a percentage of the public are potentially willing to be digitally recorded but many financial and social barriers exist. We have also highlighted areas of possible future research, namely the reluctance behind young urology patients to consent and questions regarding how best to educate possible study participants to ensure proper informed consent is gained. PMID:26005568

  18. [Collections of human biological resources for research purposes: from regulations to the need of a guide of good collection practices].

    PubMed

    Le Roux, N; de Montgolfier, S; di Donato, J-H; Boccon-Gibod, L; Teillac, P; Hervé, C; Berthon, P

    2003-12-01

    In France, collections of human biological resources are regulated by the "Bioethics Law", currently in revision. Hence, we analyse the regulatory and ethical issues of these practices in the context of scientific research. The ultimate aim of such collections is to improve biological and medical knowledge. We think that the French regulatory system is quite complicated and non-explicit for "collection holders". The multiplicity of legal texts concerning this activity has made their application difficult, especially in the absence of application decrees. The project amending the actual law has clarified the legal status of collections but it did not shed light on the status of human body detached parts. Furthermore, the text is still very far from the international bioethical recommendations, and does not reflect the actual collection's implementation. The establishment of a guideline of Good Collection Practices, based on clear principles, should help to simplify the situation, especially when it is imbedded in the regulation and linked to control procedures. It would allow a balance between collective interests and the protection of individuals, taking into account of the international highly competitive scientific and economical constraints. The major issue is to preserve and to perpetuate the existing and future collections because of their precious value as an important tool for biomedical knowledge. The efficiency of a regulation depends on its legibility and accessibility, two requirements that seem to determine the acceptance of the regulatory tool and its application allowing subsequently to reach fairness in proceedings.

  19. Challenges in researching violence affecting health service delivery in complex security environments.

    PubMed

    Foghammar, Ludvig; Jang, Suyoun; Kyzy, Gulzhan Asylbek; Weiss, Nerina; Sullivan, Katherine A; Gibson-Fall, Fawzia; Irwin, Rachel

    2016-08-01

    Complex security environments are characterized by violence (including, but not limited to "armed conflict" in the legal sense), poverty, environmental disasters and poor governance. Violence directly affecting health service delivery in complex security environments includes attacks on individuals (e.g. doctors, nurses, administrators, security guards, ambulance drivers and translators), obstructions (e.g. ambulances being stopped at checkpoints), discrimination (e.g. staff being pressured to treat one patient instead of another), attacks on and misappropriation of health facilities and property (e.g. vandalism, theft and ambulance theft by armed groups), and the criminalization of health workers. This paper examines the challenges associated with researching the context, scope and nature of violence directly affecting health service delivery in these environments. With a focus on data collection, it considers how these challenges affect researchers' ability to analyze the drivers of violence and impact of violence. This paper presents key findings from two research workshops organized in 2014 and 2015 which convened researchers and practitioners in the fields of health and humanitarian aid delivery and policy, and draws upon an analysis of organizational efforts to address violence affecting healthcare delivery and eleven in-depth interviews with representatives of organizations working in complex security environments. Despite the urgency and impact of violence affecting healthcare delivery, there is an overall lack of research that is of health-specific, publically accessible and comparable, as well as a lack of gender-disaggregated data, data on perpetrator motives and an assessment of the 'knock-on' effects of violence. These gaps limit analysis and, by extension, the ability of organizations operating in complex security environments to effectively manage the security of their staff and facilities and to deliver health services. Increased research

  20. Community-based participatory research in complex settings: clean mind-dirty hands.

    PubMed

    Makhoul, Jihad; Nakkash, Rima; Harpham, Trudy; Qutteina, Yara

    2014-09-01

    Despite the abundance of the literature which discusses factors supporting or inhibiting effective participation of community members in community-based research, there is a paucity of publications analysing challenges to participation in complex settings. This manuscript describes an intervention built on researcher-community partnership amid complex social conditions which challenged participation of community members at different stages of the research process. The research took place in a Palestinian refugee camp in Beirut, Lebanon and 1 of 12 in Lebanon which suffer from deteriorating social, economic and physical conditions perpetuated by state-imposed restrictions. The research team developed a community coalition which was involved in all stages of planning, designing, implementation and dissemination. In all those stages the aim was to maintain rigorous research, to follow a 'clean mind' approach to research, but maintain principles of community participation which necessitate 'a dirty hand'. Despite commitment to the principles of community-based participatory research, participation of community members (including youth, parents and teachers) was affected to a great extent by the social, physical and structural conditions of the community context. Characteristics of the context where research is conducted and how it affects community members should not be overlooked since multiple factors beyond the researchers' control could interfere with the rigour of scientific research. Researchers need to develop a plan for participation with the community from the beginning with an understanding of the community forces that affect meaningful participation and address possible deterrence. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine

    PubMed Central

    Wang, Xiaoyan; Laubenbacher, Reinhard C.

    2017-01-01

    Background Investigations into the factors behind coauthorship growth in biomedical research have mostly focused on specific disciplines or journals, and have rarely controlled for factors in combination or considered changes in their effects over time. Observers often attribute the growth to the increasing complexity or competition (or both) of research practices, but few attempts have been made to parse the contributions of these two likely causes. Objectives We aimed to assess the effects of complexity and competition on the incidence and growth of coauthorship, using a sample of the biomedical literature spanning multiple journals and disciplines. Methods Article-level bibliographic data from PubMed were combined with publicly available bibliometric data from Web of Science and SCImago over the years 1999–2007. We selected four predictors of coauthorship were selected, two (study type, topical scope of the study) associated with complexity and two (financial support for the project, popularity of the publishing journal) associated with competition. A negative binomial regression model was used to estimate the effects of each predictor on coauthorship incidence and growth. A second, mixed-effect model included the journal as a random effect. Results Coauthorship increased at about one author per article per decade. Clinical trials, supported research, and research of broader scope produced articles with more authors, while review articles credited fewer; and more popular journals published higher-authorship articles. Incidence and growth rates varied widely across journals and were themselves uncorrelated. Most effects remained statistically discernible after controlling for the publishing journal. The effects of complexity-associated factors held constant or diminished over time, while competition-related effects strengthened. These trends were similar in size but not discernible from subject-specific subdata. Conclusions Coauthorship incidence rates are

  2. Infrastructure and resources for an aging population: embracing complexity in translational research.

    PubMed

    High, Kevin P

    2014-05-01

    The population of the United States and most industrialized nations is undergoing rapid expansion of persons aged 65 years and older. This group experiences more illness, disability, and dependency than young adults and consumes the majority of heath care resources. This demographic change presents a number of challenges to current research infrastructure aimed at translating discoveries to improved human health. Key issues include the need to expand the workforce trained in aging research, development of specific resources and harmonization of measures and outcomes, and a culture change within the scientific community. In particular, complexity must be represented within research design and embraced as an important aspect of review panel critiques.

  3. High-Performance, Low-Complexity Codes Researched for Communication Channels

    NASA Technical Reports Server (NTRS)

    Kwatra, Subhash C.; Jones, Robert E.

    1999-01-01

    NASA Lewis Research Center s Communications Technology Division has an ongoing program in the development of efficient channel coding schemes for satellite communications applications. Through a university grant, as a part of this research, the University of Toledo is investigating the performance of turbocodes, which use parallel concatenation of non-systematic convolutional encoders with an interleaver. The error correcting capacity of these codes is close to the Shannon limit. The research emphasis is on the development of low-complexity, but higher rate (greater than one half), turbocodes and on the iterative decoding of block codes.

  4. Public responses to the sharing and linkage of health data for research purposes: a systematic review and thematic synthesis of qualitative studies.

    PubMed

    Aitken, Mhairi; de St Jorre, Jenna; Pagliari, Claudia; Jepson, Ruth; Cunningham-Burley, Sarah

    2016-11-10

    The past 10 years have witnessed a significant growth in sharing of health data for secondary uses. Alongside this there has been growing interest in the public acceptability of data sharing and data linkage practices. Public acceptance is recognised as crucial for ensuring the legitimacy of current practices and systems of governance. Given the growing international interest in this area this systematic review and thematic synthesis represents a timely review of current evidence. It highlights the key factors influencing public responses as well as important areas for further research. This paper reports a systematic review and thematic synthesis of qualitative studies examining public attitudes towards the sharing or linkage of health data for research purposes. Twenty-five studies were included in the review. The included studies were conducted primarily in the UK and North America, with one study set in Japan, another in Sweden and one in multiple countries. The included studies were conducted between 1999 and 2013 (eight studies selected for inclusion did not report data collection dates). The qualitative methods represented in the studies included focus groups, interviews, deliberative events, dialogue workshops and asynchronous online interviews. Key themes identified across the corpus of studies related to the conditions necessary for public support/acceptability, areas of public concern and implications for future research. The results identify a growing body of evidence pointing towards widespread general-though conditional-support for data linkage and data sharing for research purposes. Whilst a variety of concerns were raised (e.g. relating to confidentiality, individuals' control over their data, uses and abuses of data and potential harms arising) in cases where participants perceived there to be actual or potential public benefits from research and had trust in the individuals or organisations conducting and/or overseeing data linkage/sharing, they

  5. Establishing an Environmental Simulation Facility For Complex (Dusty) Space Plasma Research

    NASA Astrophysics Data System (ADS)

    Laufer, Rene; Matthews, Lorin; Herdrich, Georg; Srama, Ralf; Roeser, Hans-Peter

    Over the past decade, investigations into complex dusty plasmas have improved our under-standing of planetary environments, moons (including Earth's Moon), ring systems and comets. They have also been instrumental in the advancement of semiconductor development, nanofab-rication and are proving helpful in mitigating the dust contamination problems found within nuclear fusion devices such as ITER. Recently, the Lunar Exploration Analysis Group (LEAG) identified a need for research on the lunar dust and plasma environment. As part of its goal to expand current research capability in this area, the Center for Astrophysics, Space Physics and Engineering Research (CASPER) at Baylor University and its partners plan to establish a highly flexible space plasma environment simulation facility. This facility will consist of an adjustable inductively-heated plasma generator (IPG) coupled to a variety of systems allowing the introduction of the additional components (e.g. levitating or accelerated dust, UV light, ionized particles) necessary to accurately simulate a given plasma environment. Potential re-search for such a device includes investigations of complex (dusty) plasma effects on the surface of planets, moons and comets, interactions between complex (dusty) plasma and spacecraft materials and components, in-situ instrument development and testing as well as research and development for industrial applications. All of these will be discussed.

  6. S2O - A software tool for integrating research data from general purpose statistic software into electronic data capture systems.

    PubMed

    Bruland, Philipp; Dugas, Martin

    2017-01-07

    Data capture for clinical registries or pilot studies is often performed in spreadsheet-based applications like Microsoft Excel or IBM SPSS. Usually, data is transferred into statistic software, such as SAS, R or IBM SPSS Statistics, for analyses afterwards. Spreadsheet-based solutions suffer from several drawbacks: It is generally not possible to ensure a sufficient right and role management; it is not traced who has changed data when and why. Therefore, such systems are not able to comply with regulatory requirements for electronic data capture in clinical trials. In contrast, Electronic Data Capture (EDC) software enables a reliable, secure and auditable collection of data. In this regard, most EDC vendors support the CDISC ODM standard to define, communicate and archive clinical trial meta- and patient data. Advantages of EDC systems are support for multi-user and multicenter clinical trials as well as auditable data. Migration from spreadsheet based data collection to EDC systems is labor-intensive and time-consuming at present. Hence, the objectives of this research work are to develop a mapping model and implement a converter between the IBM SPSS and CDISC ODM standard and to evaluate this approach regarding syntactic and semantic correctness. A mapping model between IBM SPSS and CDISC ODM data structures was developed. SPSS variables and patient values can be mapped and converted into ODM. Statistical and display attributes from SPSS are not corresponding to any ODM elements; study related ODM elements are not available in SPSS. The S2O converting tool was implemented as command-line-tool using the SPSS internal Java plugin. Syntactic and semantic correctness was validated with different ODM tools and reverse transformation from ODM into SPSS format. Clinical data values were also successfully transformed into the ODM structure. Transformation between the spreadsheet format IBM SPSS and the ODM standard for definition and exchange of trial data is feasible

  7. The center for plant and microbial complex carbohydrates at the University of Georgia Complex Carbohydrate Research Center

    SciTech Connect

    Albersheim, P.; Darvill, A.

    1991-08-01

    Research from the Complex Carbohydrates Research Center at the University of Georgia is presented. Topics include: Structural determination of soybean isoflavones which specifically induce Bradyrhizobium japonicum nodD1 but not the nodYABCSUIJ operon; structural analysis of the lipopolysaccharides (LPSs) from symbiotic mutants of Bradyrhizobium japonicum; structural characterization of lipooligosaccharides from Bradyrhizobium japonicum that are required for the specific nodulation of soybean; structural characterization of the LPSs from R. Leguminosarum biovar phaseoli, the symbiont of bean; characterization of bacteroid-specific LPS epitopes in R. leguminosarum biovar viciae; analysis of the surface polysaccharides of Rhizobium meliloti mutants whose lipopolysaccharides and extracellular polysaccharides can have the same function in symbiosis; characterization of a polysaccharide produced by certain Bradyrhizobium japonicum strains within soybean nodules; structural analysis of a streptococcal adhesin polysaccharide receptor; conformational studies of xyloglucan, the role of the fucosylated side chain in surface-specific cellulose-xyloglucan interactions; the structure of an acylated glucosamine oligosaccharide signal molecule (nod factor) involved in the symbiosis of Rhizobium leguminosarum biovar viciae with its host Vicia sativa; investigating membrane responses induced by oligogalacturonides in cultured cells; the polygalacturonase inhibitor protein; characterization of the self-incompatability glycoproteins from Petunia hybrida; investigation of the cell wall polysaccharide structures of Arabidopsis thaliana; and the glucan inhibition of virus infection of tabacco.

  8. Sustainability, Complexity and Learning: Insights from Complex Systems Approaches

    ERIC Educational Resources Information Center

    Espinosa, A.; Porter, T.

    2011-01-01

    Purpose: The purpose of this research is to explore core contributions from two different approaches to complexity management in organisations aiming to improve their sustainability,: the Viable Systems Model (VSM), and the Complex Adaptive Systems (CAS). It is proposed to perform this by summarising the main insights each approach offers to…

  9. Sustainability, Complexity and Learning: Insights from Complex Systems Approaches

    ERIC Educational Resources Information Center

    Espinosa, A.; Porter, T.

    2011-01-01

    Purpose: The purpose of this research is to explore core contributions from two different approaches to complexity management in organisations aiming to improve their sustainability,: the Viable Systems Model (VSM), and the Complex Adaptive Systems (CAS). It is proposed to perform this by summarising the main insights each approach offers to…

  10. Extending the theoretical framing for physics education research: An illustrative application of complexity science

    NASA Astrophysics Data System (ADS)

    Forsman, Jonas; Moll, Rachel; Linder, Cedric

    2014-12-01

    The viability of using complexity science in physics education research (PER) is exemplified by (1) situating central tenets of student persistence research in complexity science and (2) drawing on the methods that become available from this to illustrate analyzing the structural aspects of students' networked interactions as an important dynamic in student persistence. By drawing on the most cited characterizations of student persistence, we theorize that university environments are made up of social and academic systems, which PER work on student persistence has largely ignored. These systems are interpreted as being constituted from rules of interaction that affect the structural aspects of students' social and academic network interactions from a complexity science perspective. To illustrate this empirically, an exploration of the nature of the social and academic networks of university-level physics students is undertaken. This is done by combining complexity science with social network analysis to characterize structural similarities and differences of the social and academic networks of students in two courses. It is posited that framing a social network analysis within a complexity science perspective offers a new and powerful applicability across a broad range of PER topics.

  11. Towards Advancing Knowledge Translation of AAC Outcomes Research for Children and Youth with Complex Communication Needs.

    PubMed

    Ryan, Stephen E; Shepherd, Tracy; Renzoni, Anne Marie; Anderson, Colleen; Barber, Mary; Kingsnorth, Shauna; Ward, Karen

    2015-06-01

    The production of new knowledge in augmentative and alternative communication (AAC) requires effective processes to leverage the different perspectives of researchers and knowledge users and improve prospects for utilization in clinical settings. This article describes the motivation, planning, process, and outcomes for a novel knowledge translation workshop designed to influence future directions for AAC outcomes research for children with complex communication needs. Invited knowledge users from 20 pediatric AAC clinics and researchers engaged in the collaborative development of research questions using a framework designed for the AAC field. The event yielded recommendations for research and development priorities that extend from the early development of language, communication, and literacy skills in very young children, to novel but unproven strategies that may advance outcomes in transitioning to adulthood.

  12. An open debate about the object and purpose of global health knowledge in the context of an interdisciplinary research partnership on HIV/STI prevention priorities in Peru.

    PubMed

    Suarez, Eliana Barrios; Logie, Carmen; Arocha, Jose F

    2014-05-21

    With the failure of the latest vaccine trial, HVTN-505, HIV prevention efforts remain critical. Social and structural factors contributing to HIV and STI transmission include stigma regarding sexual violence, HIV infection and sexual orientation. For instance, HIV prevention and overall sexual health programs in Peru have been implemented yet key populations of youth (sex workers, male and transgender youth) continue to be overrepresented in new cases of HIV and STI. This suggests that interventions must take new directions and highlights the need for additional research. While interdisciplinary, international research collaborations often are indicated as best practice in developing new knowledge in global health and an important component of the leadership in health systems, this does not mean they are free of challenges. In this debate we document our reflections on some of the challenges in developing an interdisciplinary and international research team to understand HIV and STI prevention priorities among youth in two culturally diverse cities in Peru: Lima, the capital city, and Ayacucho, in the Andean region. Rather than offering solutions we aim to contribute to the debate about the object and purpose of global health research in the context of developing international research partnerships that genuinely promote a reciprocal and bidirectional flow of knowledge between the Global South and the Global North, and researchers at intersections of these locations.

  13. An open debate about the object and purpose of global health knowledge in the context of an interdisciplinary research partnership on HIV/STI prevention priorities in Peru

    PubMed Central

    2014-01-01

    Background With the failure of the latest vaccine trial, HVTN-505, HIV prevention efforts remain critical. Social and structural factors contributing to HIV and STI transmission include stigma regarding sexual violence, HIV infection and sexual orientation. For instance, HIV prevention and overall sexual health programs in Peru have been implemented yet key populations of youth (sex workers, male and transgender youth) continue to be overrepresented in new cases of HIV and STI. This suggests that interventions must take new directions and highlights the need for additional research. Discussion While interdisciplinary, international research collaborations often are indicated as best practice in developing new knowledge in global health and an important component of the leadership in health systems, this does not mean they are free of challenges. In this debate we document our reflections on some of the challenges in developing an interdisciplinary and international research team to understand HIV and STI prevention priorities among youth in two culturally diverse cities in Peru: Lima, the capital city, and Ayacucho, in the Andean region. Summary Rather than offering solutions we aim to contribute to the debate about the object and purpose of global health research in the context of developing international research partnerships that genuinely promote a reciprocal and bidirectional flow of knowledge between the Global South and the Global North, and researchers at intersections of these locations. PMID:24886493

  14. Systems and complexity thinking in general practice. Part 2: application in primary care research.

    PubMed

    Sturmberg, Joachim P

    2007-04-01

    Systems organise themselves upward toward larger wholes, and downward toward ever smaller parts. The upward view describes holism or emergence (complexity science view), the downward view reductionism or analysis (Newtonian science view). Both views provide valid and valuable information, one being contextual, the other specific. A systems and complexity view allows a simultaneous understanding of a phenomenon from different perspectives, providing the opportunity to identify potentially different outcomes from a single action. The findings from studies on prescribing antibiotics and continuity of care will demonstrate and draw attention to the potential of this approach for primary care research.

  15. A hardware-software complex for modelling and research of near navigation based on pseudolites

    NASA Astrophysics Data System (ADS)

    Gladyshev, A. B.; Dmitriev, D. D.; Veysov, E. A.; Tyapkin, V. N.

    2017-01-01

    The paper considers a hardware-software complex for research of characteristics of accuracy and noise immunity of a near navigation system based on pseudolites. The complex is implemented on the basis of the “National Instruments” hardware platform and “LabView” coding environment. It provides a simulated navigation field, the analysis of the received signals, the determination of the errors of measurement of navigation parameters for pseudolites signals, comparing the measured error with the characteristics of a standard GNSS receiver.

  16. [Application of hair analysis of selected psychoactive substances for medico-legal purposes. Part II. Cases of complex fatal poisonings: interactions of heroine - cocaine - amphetamines].

    PubMed

    Rojek, Sebastian; Kłys, Małgorzata; Rzepecka-Woźniak, Ewa; Konopka, Tomasz

    2010-01-01

    The study represents an attempt at employing segmental hair analysis in complex poisonings with xenobiotic mixtures of heroine - cocaine - amphetamines in the context of the cause of death as a consequence of complex interaction mechanisms which occurred prior to death. Two cases of complex poisonings: heroine - cocaine and heroine - cocaine - amphetamines were analyzed and documented with macro- and microscopic examinations and complex toxicological examinations, including the analysis of classic biological material, i.e. samples of selective blood, and alternative material, i.e. hair samples. Determinations of opioids, cocaine and its metabolite and amphetamines in the hair biological matrix were performed using high performance liquid chromatography--atmospheric pressure chemical ionization--tandem mass spectrometry (HPLC-APCI-MS-MS). Segmental hair analysis of the investigated cases indicated a prolonged intake of similar psychoactive substances and a developed adaptation of the addicted to interaction mechanisms, which, however, led gradually to multiorgan anatomopathological changes, and in consequence to death.

  17. Research design issues for evaluating complex multicomponent interventions in neighborhoods and communities.

    PubMed

    Komro, Kelli A; Flay, Brian R; Biglan, Anthony; Wagenaar, Alexander C

    2016-03-01

    Major advances in population health will not occur unless we translate existing knowledge into effective multicomponent interventions, implement and maintain these in communities, and develop rigorous translational research and evaluation methods to ensure continual improvement and sustainability. We discuss challenges and offer approaches to evaluation that are key for translational research stages 3 to 5 to advance optimized adoption, implementation, and maintenance of effective and replicable multicomponent strategies. The major challenges we discuss concern (a) multiple contexts of evaluation/research, (b) complexity of packages of interventions, and (c) phases of evaluation/research questions. We suggest multiple alternative research designs that maintain rigor but accommodate these challenges and highlight the need for measurement systems. Longitudinal data collection and a standardized continuous measurement system are fundamental to the evaluation and refinement of complex multicomponent interventions. To be useful to T3-T5 translational research efforts in neighborhoods and communities, such a system would include assessments of the reach, implementation, effects on immediate outcomes, and effects of the comprehensive intervention package on more distal health outcomes.

  18. Using video-based observation research methods in primary care health encounters to evaluate complex interactions

    PubMed Central

    Asan, Onur; Montague, Enid

    2015-01-01

    Objective The purpose of this paper is to describe the use of video-based observation research methods in primary care environment and highlight important methodological considerations and provide practical guidance for primary care and human factors researchers conducting video studies to understand patient-clinician interaction in primary care settings. Methods We reviewed studies in the literature which used video methods in health care research and, we also used our own experience based on the video studies we conducted in primary care settings. Results This paper highlighted the benefits of using video techniques such as multi-channel recording and video coding and compared “unmanned” video recording with the traditional observation method in primary care research. We proposed a list, which can be followed step by step to conduct an effective video study in a primary care setting for a given problem. This paper also described obstacles researchers should anticipate when using video recording methods in future studies. Conclusion With the new technological improvements, video-based observation research is becoming a promising method in primary care and HFE research. Video recording has been under-utilized as a data collection tool because of confidentiality and privacy issues. However, it has many benefits as opposed to traditional observations, and recent studies using video recording methods have introduced new research areas and approaches. PMID:25479346

  19. Using video-based observation research methods in primary care health encounters to evaluate complex interactions.

    PubMed

    Asan, Onur; Montague, Enid

    2014-01-01

    The purpose of this paper is to describe the use of video-based observation research methods in primary care environment and highlight important methodological considerations and provide practical guidance for primary care and human factors researchers conducting video studies to understand patient-clinician interaction in primary care settings. We reviewed studies in the literature which used video methods in health care research, and we also used our own experience based on the video studies we conducted in primary care settings. This paper highlighted the benefits of using video techniques, such as multi-channel recording and video coding, and compared "unmanned" video recording with the traditional observation method in primary care research. We proposed a list that can be followed step by step to conduct an effective video study in a primary care setting for a given problem. This paper also described obstacles, researchers should anticipate when using video recording methods in future studies. With the new technological improvements, video-based observation research is becoming a promising method in primary care and HFE research. Video recording has been under-utilised as a data collection tool because of confidentiality and privacy issues. However, it has many benefits as opposed to traditional observations, and recent studies using video recording methods have introduced new research areas and approaches.

  20. [The use of the functional dynamic complex of verbal skills for the purpose of forensic medical personality identification of the speaker].

    PubMed

    Kaganov, A Sh

    2013-01-01

    The objective of this work was to analyse the functional dynamic complex (FDC) of verbal skills and to substantiate the possibility of using such complexes for personality identification of the speaker. The problems of formation, manifestations, and stability of verbal skill FDCs as well as their role as a source of medico-criminalistic information are discussed. This report is based on the review of the literature publications and materials of practical forensic medical investigations.

  1. Performance of the Research Animal Holding Facility (RAHF) and General Purpose Work Station (GPWS) and other hardware in the microgravity environment

    NASA Technical Reports Server (NTRS)

    Hogan, Robert P.; Dalton, Bonnie P.

    1991-01-01

    This paper discusses the performance of the Research Animal Holding Facility (RAHF) and General Purpose Work Station (GPWS) plus other associated hardware during the recent flight of Spacelab Life Sciences 1 (SLS-1). The RAHF was developed to provide proper housing (food, water, temperature control, lighting and waste management) for up to 24 rodents during flights on the Spacelab. The GPWS was designed to contain particulates and toxic chemicals generated during plant and animal handling and dissection/fixation activities during space flights. A history of the hardware development involves as well as the redesign activities prior to the actual flight are discussed.

  2. Performance of the Research Animal Holding Facility (RAHF) and General Purpose Work Station (GPWS) and other hardware in the microgravity environment

    NASA Technical Reports Server (NTRS)

    Hogan, Robert P.; Dalton, Bonnie P.

    1991-01-01

    This paper discusses the performance of the Research Animal Holding Facility (RAHF) and General Purpose Work Station (GPWS) plus other associated hardware during the recent flight of Spacelab Life Sciences 1 (SLS-1). The RAHF was developed to provide proper housing (food, water, temperature control, lighting and waste management) for up to 24 rodents during flights on the Spacelab. The GPWS was designed to contain particulates and toxic chemicals generated during plant and animal handling and dissection/fixation activities during space flights. A history of the hardware development involves as well as the redesign activities prior to the actual flight are discussed.

  3. A complex, nonlinear dynamic systems perspective on Ayurveda and Ayurvedic research.

    PubMed

    Rioux, Jennifer

    2012-07-01

    The fields of complexity theory and nonlinear dynamic systems (NDS) are relevant for analyzing the theory and practice of Ayurvedic medicine from a Western scientific perspective. Ayurvedic definitions of health map clearly onto the tenets of both systems and complexity theory and focus primarily on the preservation of organismic equanimity. Health care research informed by NDS and complexity theory would prioritize (1) ascertaining patterns reflected in whole systems as opposed to isolating components; (2) relationships and dynamic interaction rather than static end-points; (3) transitions, change and cumulative effects, consistent with delivery of therapeutic packages in the reality of the clinical setting; and (4) simultaneously exploring both local and global levels of healing phenomena. NDS and complexity theory are useful in examining nonlinear transitions between states of health and illness; the qualitative nature of shifts in health status; and looking at emergent properties and behaviors stemming from interactions between organismic and environmental systems. Complexity and NDS theory also demonstrate promise for enhancing the suitability of research strategies applied to Ayurvedic medicine through utilizing core concepts such as initial conditions, emergent properties, fractal patterns, and critical fluctuations. In the Ayurvedic paradigm, multiple scales and their interactions are addressed simultaneously, necessitating data collection on change patterns that occur on continuums of both time and space, and are viewed as complementary rather than isolated and discrete. Serious consideration of Ayurvedic clinical understandings will necessitate new measurement options that can account for the relevance of both context and environmental factors, in terms of local biology and the processual features of the clinical encounter. Relevant research design issues will need to address clinical tailoring strategies and provide mechanisms for mapping patterns of

  4. A Complex, Nonlinear Dynamic Systems Perspective on Ayurveda and Ayurvedic Research

    PubMed Central

    2012-01-01

    Abstract The fields of complexity theory and nonlinear dynamic systems (NDS) are relevant for analyzing the theory and practice of Ayurvedic medicine from a Western scientific perspective. Ayurvedic definitions of health map clearly onto the tenets of both systems and complexity theory and focus primarily on the preservation of organismic equanimity. Health care research informed by NDS and complexity theory would prioritize (1) ascertaining patterns reflected in whole systems as opposed to isolating components; (2) relationships and dynamic interaction rather than static end-points; (3) transitions, change and cumulative effects, consistent with delivery of therapeutic packages in the reality of the clinical setting; and (4) simultaneously exploring both local and global levels of healing phenomena. NDS and complexity theory are useful in examining nonlinear transitions between states of health and illness; the qualitative nature of shifts in health status; and looking at emergent properties and behaviors stemming from interactions between organismic and environmental systems. Complexity and NDS theory also demonstrate promise for enhancing the suitability of research strategies applied to Ayurvedic medicine through utilizing core concepts such as initial conditions, emergent properties, fractal patterns, and critical fluctuations. In the Ayurvedic paradigm, multiple scales and their interactions are addressed simultaneously, necessitating data collection on change patterns that occur on continuums of both time and space, and are viewed as complementary rather than isolated and discrete. Serious consideration of Ayurvedic clinical understandings will necessitate new measurement options that can account for the relevance of both context and environmental factors, in terms of local biology and the processual features of the clinical encounter. Relevant research design issues will need to address clinical tailoring strategies and provide mechanisms for mapping

  5. DNA methylation in complex disease: applications in nursing research, practice, and policy.

    PubMed

    Wright, Michelle L; Ralph, Jody L; Ohm, Joyce E; Anderson, Cindy M

    2013-01-01

    DNA methylation is an epigenomic modification that is essential to normal human development and biological processes. DNA methylation patterns are heritable and dynamic throughout the life span. Environmental exposures can alter DNA methylation patterns, contributing to the development of complex disease. Identification and modulation of environmental factors influencing disease susceptibility through alterations in DNA methylation are amenable to nursing intervention and form the basis for individualized patient care. Here we describe the evidence supporting the translation of DNA methylation analyses as a tool for screening, diagnosis, and treatment of complex disease in nursing research and practice. The ethical, legal, social, and economic considerations of advances in genomics are considered as a model for epigenomic policy. We conclude that contemporary and informed nurse scientists and clinicians are uniquely poised to apply innovations in epigenomic research to clinical populations and develop appropriate policies that guide equitable and ethical use of new strategies to improve patient care.

  6. Developing a framework for qualitative engineering: Research in design and analysis of complex structural systems

    NASA Technical Reports Server (NTRS)

    Franck, Bruno M.

    1990-01-01

    The research is focused on automating the evaluation of complex structural systems, whether for the design of a new system or the analysis of an existing one, by developing new structural analysis techniques based on qualitative reasoning. The problem is to identify and better understand: (1) the requirements for the automation of design, and (2) the qualitative reasoning associated with the conceptual development of a complex system. The long-term objective is to develop an integrated design-risk assessment environment for the evaluation of complex structural systems. The scope of this short presentation is to describe the design and cognition components of the research. Design has received special attention in cognitive science because it is now identified as a problem solving activity that is different from other information processing tasks (1). Before an attempt can be made to automate design, a thorough understanding of the underlying design theory and methodology is needed, since the design process is, in many cases, multi-disciplinary, complex in size and motivation, and uses various reasoning processes involving different kinds of knowledge in ways which vary from one context to another. The objective is to unify all the various types of knowledge under one framework of cognition. This presentation focuses on the cognitive science framework that we are using to represent the knowledge aspects associated with the human mind's abstraction abilities and how we apply it to the engineering knowledge and engineering reasoning in design.

  7. Final report: A Broad Research Project in the Sciences of Complexity

    SciTech Connect

    2000-02-01

    Previous DOE support for ''A Broad Research Program in the Sciences of Complexity'' permitted the Santa Fe Institute to initiate new collaborative research within its Integrative Core activities as well as to host visitors to participate in research on specific topics that serve as motivation and testing-ground for the study of general principles of complex systems. The critical aspect of this support is its effectiveness in seeding new areas of research. Indeed, this Integrative Core has been the birthplace of dozens of projects that later became more specifically focused and then won direct grant support independent of the core grants. But at early stages most of this multidisciplinary research was unable to win grant support as individual projects--both because it did not match well with existing grant program guidelines, and because the amount of handing needed was often too modest to justify a formal proposal to an agency. In fact, one of the attributes of core support has been that it permitted SFI to encourage high-risk activities because the cost was quite low. What is significant is how many of those initial efforts have been productive in the SFI environment. Many of SFI'S current research foci began with a short visit from a researcher new to the SFI community, or as small working groups that brought together carefully selected experts from a variety of fields. As mentioned above, many of the ensuing research projects are now being supported by other funding agencies or private foundations. Some of these successes are described.

  8. Final Report: A Broad Research Project on the Sciences of Complexity, September 15, 1994 - November 15, 1999

    SciTech Connect

    2000-02-01

    DOE support for a broad research program in the sciences of complexity permitted the Santa Fe Institute to initiate new collaborative research within its integrative core activities as well as to host visitors to participate in research on specific topics that serve as motivation and testing ground for the study of the general principles of complex systems. Results are presented on computational biology, biodiversity and ecosystem research, and advanced computing and simulation.

  9. Unmanned Aerial Vehicle - A Tool for Acquiring Spatial Data for Research and Commercial Purposes. New Course in the Geography and Cartography Curriculum in Higher Education

    NASA Astrophysics Data System (ADS)

    Jeziorska, J.

    2014-04-01

    This paper describes the syllabus for the innovative course "Unmanned aerial observations of Terrain" introduced to the curriculum by the Department of Geoinformatics and Cartography of the University of Wroclaw (Poland). It indicates the objectives of the new subject, its didactic purpose, methods used in the teaching process, specifications of teaching materials, and the knowledge and skills that students are expected to acquire. Finally, it presents the content of the course and description of lesson units. The subject will be obligatory for graduate students majoring in Geography, who are participants in the Geoinformatics and Cartography Master's program. Thirty-eight hours in a summer semester has been earmarked for the course. That includes 30 hours of instructor-guided laboratory and fieldtrip work, and 8 hours of individual work. The course aims to prepare future geographers to conduct a multi-step process that includes defining the purpose of using UAV in light of the chosen research problem, preparation of the mission, flight execution; geoprocessing of acquired aerial imagery; generation of cartomertic final products, and analysis of outcomes in order to answer the initially asked research question. This comprehensive approach will allow students, future experts in the field of geoinformatics and cartography, to gain the skills needed to acquire spatial data using an UAV, process them, and apply the results of their analysis in practice.

  10. Designing AAC Research and Intervention to Improve Outcomes for Individuals with Complex Communication Needs.

    PubMed

    Light, Janice; Mcnaughton, David

    2015-06-01

    There is a rapidly growing body of research that demonstrates the positive effects of augmentative and alternative communication (AAC) intervention on the communication of children and adults with complex communication needs. Despite the positive impact of many AAC interventions, however, many individuals with complex communication needs continue to experience serious challenges participating in educational, vocational, healthcare, and community environments. In this paper, we apply the framework proposed by the International Classification of Functioning, Disability and Health (ICF) to illustrate the need to re-think AAC intervention to improve outcomes for individuals with complex communication needs, and to foster a new generation of intervention research that will provide a solid foundation for improved services. Specifically, the paper emphasizes the need to take a more holistic view of communication intervention and highlights the following key principles to guide AAC intervention and research: (a) build on the individual's strengths and focus on the integration of skills to maximize communication, (b) focus on the individual's participation in real-world contexts,

  11. Exome Sequencing and Unrelated Findings in the Context of Complex Disease Research: Ethical and Clinical Implications

    PubMed Central

    Lyon, Gholson J.; Jiang, Tao; Van Wijk, Richard; Wang, Wei; Bodily, Paul Mark; Xing, Jinchuan; Tian, Lifeng; Robison, Reid J.; Clement, Mark; Lin, Yang; Zhang, Peng; Liu, Ying; Moore, Barry; Glessner, Joseph T.; Elia, Josephine; Reimherr, Fred; van Solinge, Wouter W.; Yandell, Mark; Hakonarson, Hakon; Wang, Jun; Johnson, William Evan; Wei, Zhi; Wang, Kai

    2012-01-01

    Exome sequencing has identified the causes of several Mendelian diseases, although it has rarely been used in a clinical setting to diagnose the genetic cause of an idiopathic disorder in a single patient. We performed exome sequencing on a pedigree with several members affected with attention deficit/hyperactivity disorder (ADHD), in an effort to identify candidate variants predisposing to this complex disease. While we did identify some rare variants that might predispose to ADHD, we have not yet proven the causality for any of them. However, over the course of the study, one subject was discovered to have idiopathic hemolytic anemia (IHA), which was suspected to be genetic in origin. Analysis of this subject’s exome readily identified two rare non-synonymous mutations in PKLR gene as the most likely cause of the IHA, although these two mutations had not been documented before in a single individual. We further confirmed the deficiency by functional biochemical testing, consistent with a diagnosis of red blood cell pyruvate kinase deficiency. Our study implies that exome and genome sequencing will certainly reveal additional rare variation causative for even well-studied classical Mendelian diseases, while also revealing variants that might play a role in complex diseases. Furthermore, our study has clinical and ethical implications for exome and genome sequencing in a research setting; how to handle unrelated findings of clinical significance, in the context of originally planned complex disease research, remains a largely uncharted area for clinicians and researchers. PMID:21794208

  12. International Microgravity Plasma Facility IMPF: A Multi-User Modular Research Facility for Complex Plasma Research on ISS

    NASA Astrophysics Data System (ADS)

    Seurig, R.; Burfeindt, J.; Castegini, R.; Griethe, W.; Hofmann, P.

    2002-01-01

    On March 03, 2001, the PKE-Nefedov plasma experiment was successfully put into operation on board ISS. This complex plasma experiment is the predecessor for the semi-autonomous multi-user facility IMPF (International Microgravity Plasma Facility) to be flown in 2006 with an expected operational lifetime of 10 years. IMPF is envisioned to be an international research facility for investigators in the field of multi-component plasmas containing ions, electrons, and charged microparticles. This research filed is often referred to as "complex plasmas". The actual location of IMPF on ISS is not decided yet; potential infrastructure under consideration are EXPRESS Rack, Standard Interface Rack SIR, European Drawer Rack EDR, or a to be designed custom rack infrastructure on the Russian Segment. The actual development status of the DLR funded Pre-phase B Study for IMPF will be presented. For this phase, IMPF was assumed to be integrated in an EXPRESS Rack requiring four middeck lockers with two 4-PU ISIS drawers for accommodation. Technical and operational challenges, like a 240 Mbytes/sec continuous experimental data stream for 60 minutes, will be addressed. The project was funded by the German Space Agency (DLR) and was performed in close cooperation with scientists from the Max-Planck-Institute for Extraterrestical Physics in Munich, Germany.

  13. Organizational Influences on Interdisciplinary Interactions during Research and Design of Large-Scale Complex Engineered Systems

    NASA Technical Reports Server (NTRS)

    McGowan, Anna-Maria R.; Seifert, Colleen M.; Papalambros, Panos Y.

    2012-01-01

    The design of large-scale complex engineered systems (LaCES) such as an aircraft is inherently interdisciplinary. Multiple engineering disciplines, drawing from a team of hundreds to thousands of engineers and scientists, are woven together throughout the research, development, and systems engineering processes to realize one system. Though research and development (R&D) is typically focused in single disciplines, the interdependencies involved in LaCES require interdisciplinary R&D efforts. This study investigates the interdisciplinary interactions that take place during the R&D and early conceptual design phases in the design of LaCES. Our theoretical framework is informed by both engineering practices and social science research on complex organizations. This paper provides preliminary perspective on some of the organizational influences on interdisciplinary interactions based on organization theory (specifically sensemaking), data from a survey of LaCES experts, and the authors experience in the research and design. The analysis reveals couplings between the engineered system and the organization that creates it. Survey respondents noted the importance of interdisciplinary interactions and their significant benefit to the engineered system, such as innovation and problem mitigation. Substantial obstacles to interdisciplinarity are uncovered beyond engineering that include communication and organizational challenges. Addressing these challenges may ultimately foster greater efficiencies in the design and development of LaCES and improved system performance by assisting with the collective integration of interdependent knowledge bases early in the R&D effort. This research suggests that organizational and human dynamics heavily influence and even constrain the engineering effort for large-scale complex systems.

  14. How acceptable is it for HIV positive African, Caribbean and Black women to provide breast milk/fluid samples for research purposes?

    PubMed

    Kapiriri, L; Tharao, W; Muchenje, M; Khatundi, I M; Ongoiba, F

    2017-01-03

    The African, Caribbean and Black communities have been found to be reluctant to participate in health research in North America. This is partly attributed to historical experiences as well as their cultural beliefs. Cultural beliefs about the uses of breast milk/fluids could further hinder the participation of African, Caribbean, and Black communities in research involving the collection of breast milk/fluids samples. We conducted 17 in-depth interviews and three group interviews (n = 10) with HIV+ African, Caribbean and Black women living in Ontario, Canada to explore their cultural beliefs about breast milk/fluids and their acceptance of participating in research that involves the provision of breast fluid samples. Qualitative study involving in-depth interviews. Our respondents believed that breast milk/fluids should be used for infant feeding and for curative purposes for a variety of children's health ailments as well as ailments experienced by other family members. The cultural belief that breast milk/fluids could be used to bewitch the baby and mother and the perception that it is intrusive (equating breast milk/fluids research to DNA testing), could prevent African, Caribbean and Black women from participating in research involving the collection of breast milk/fluids. Despite these fears, some respondents expressed that they would participate if the research results would benefit them directly, for example, by finding a cure for HIV, enabling HIV+ mothers to breastfeed, or contributing to developing new drugs or vaccines for HIV. Women's recommendations to facilitate successful recruitment included giving incentives to participants, and employing a recruiter who was trustworthy, informed, and culturally sensitive. Cultural beliefs could present barriers to recruitment and participation of Africa, Caribbean and Black communities in health research involving breast milk/fluid samples. Successful recruitment for future studies would necessitate researchers

  15. Theory and research in audiology education: understanding and representing complexity through informed methodological decisions.

    PubMed

    Ng, Stella L

    2013-05-01

    The discipline of audiology has the opportunity to embark on research in education from an informed perspective, learning from professions that began this journey decades ago. The goal of this article is to position our discipline as a new member in the academic field of health professional education (HPE), with much to learn and contribute. In this article, I discuss the need for theory in informing HPE research. I also stress the importance of balancing our research goals by selecting appropriate methodologies for relevant research questions, to ensure that we respect the complexity of social processes inherent in HPE. Examples of relevant research questions are used to illustrate the need to consider alternative methodologies and to rethink the traditional hierarchy of evidence. I also provide an example of the thought processes and decisions that informed the design of an educational research study using a constructivist grounded theory methodology. As audiology enters the scholarly field of HPE, we need to arm ourselves with some of the knowledge and perspective that informs the field. Thus, we need to broaden our conceptions of what we consider to be appropriate styles of academic writing, relevant research questions, and valid evidence. Also, if we are to embark on qualitative inquiry into audiology education (or other audiology topics), we need to ensure that we conduct this research with an adequate understanding of the theories and methodologies informing such approaches. We must strive to conduct high quality, rigorous qualitative research more often than uninformed, generic qualitative research. These goals are imperative to the advancement of the theoretical landscape of audiology education and evolving the place of audiology in the field of HPE. American Academy of Audiology.

  16. Perception and mobility research at Defence R&D Canada for UGVs in complex terrain

    NASA Astrophysics Data System (ADS)

    Trentini, Michael; Collier, Jack; Beckman, Blake; Digney, Bruce; Vincent, Isabelle

    2007-04-01

    The Autonomous Intelligent Systems Section at Defence R&D Canada - Suffield envisions autonomous systems contributing to decisive operations in the urban battle space. In this vision, teams of unmanned ground, air, and marine vehicles, and unattended ground sensors will gather and coordinate information, formulate plans, and complete tasks. The mobility requirement for ground-based mobile systems operating in urban settings must increase significantly if robotic technology is to augment human efforts in military relevant roles and environments. In order to achieve its objective, the Autonomous Intelligent Systems Section is pursuing research that explores the use of intelligent mobility algorithms designed to improve robot mobility. Intelligent mobility uses sensing and perception, control, and learning algorithms to extract measured variables from the world, control vehicle dynamics, and learn by experience. These algorithms seek to exploit available world representations of the environment and the inherent dexterity of the robot to allow the vehicle to interact with its surroundings and produce locomotion in complex terrain. However, a disconnect exists between the current state-of-the-art in perception systems and the information required for novel platforms to interact with their environment to improve mobility in complex terrain. The primary focus of the paper is to present the research tools, topics, and plans to address this gap in perception and control research. This research will create effective intelligence to improve the mobility of ground-based mobile systems operating in urban settings to assist the Canadian Forces in their future urban operations.

  17. Capturing complexity in work disability research: application of system dynamics modeling methodology.

    PubMed

    Jetha, Arif; Pransky, Glenn; Hettinger, Lawrence J

    2016-01-01

    Work disability (WD) is characterized by variable and occasionally undesirable outcomes. The underlying determinants of WD outcomes include patterns of dynamic relationships among health, personal, organizational and regulatory factors that have been challenging to characterize, and inadequately represented by contemporary WD models. System dynamics modeling (SDM) methodology applies a sociotechnical systems thinking lens to view WD systems as comprising a range of influential factors linked by feedback relationships. SDM can potentially overcome limitations in contemporary WD models by uncovering causal feedback relationships, and conceptualizing dynamic system behaviors. It employs a collaborative and stakeholder-based model building methodology to create a visual depiction of the system as a whole. SDM can also enable researchers to run dynamic simulations to provide evidence of anticipated or unanticipated outcomes that could result from policy and programmatic intervention. SDM may advance rehabilitation research by providing greater insights into the structure and dynamics of WD systems while helping to understand inherent complexity. Challenges related to data availability, determining validity, and the extensive time and technical skill requirements for model building may limit SDM's use in the field and should be considered. Contemporary work disability (WD) models provide limited insight into complexity associated with WD processes. System dynamics modeling (SDM) has the potential to capture complexity through a stakeholder-based approach that generates a simulation model consisting of multiple feedback loops. SDM may enable WD researchers and practitioners to understand the structure and behavior of the WD system as a whole, and inform development of improved strategies to manage straightforward and complex WD cases.

  18. Race, Socioeconomic Status and Health: Complexities, Ongoing Challenges and Research Opportunities

    PubMed Central

    Williams, David R.; Mohammed, Selina A.; Leavell, Jacinta; Collins, Chiquita

    2012-01-01

    This paper provides an overview of racial variations in health and shows that differences in socioeconomic status (SES) across racial groups are a major contributor to racial disparities in health. However, race reflects multiple dimensions of social inequality and individual and household indicators of SES capture relevant but limited aspects of this phenomenon. Research is needed that will comprehensively characterize the critical pathogenic features of social environments and identify how they combine with each other to affect health over the life course. Migration history and status are also important predictors of health and research is needed that will enhance understanding of the complex ways in which race, SES, and immigrant status combine to affect health. Fully capturing the role of race in health also requires rigorous examination of the conditions under which medical care and genetic factors can contribute to racial and SES differences in health. The paper identifies research priorities in all of these areas. PMID:20201869

  19. Increasing complexity of clinical research in gastroenterology: implications for the training of clinician-scientists.

    PubMed

    Scott, Frank I; McConnell, Ryan A; Lewis, Matthew E; Lewis, James D

    2012-04-01

    Significant advances have been made in clinical and epidemiologic research methods over the past 30 years. We sought to demonstrate the impact of these advances on published gastroenterology research from 1980 to 2010. Twenty original clinical articles were randomly selected from each of three journals from 1980, 1990, 2000, and 2010. Each article was assessed for topic, whether the outcome was clinical or physiologic, study design, sample size, number of authors and centers collaborating, reporting of various statistical methods, and external funding. From 1980 to 2010, there was a significant increase in analytic studies, clinical outcomes, number of authors per article, multicenter collaboration, sample size, and external funding. There was increased reporting of P values, confidence intervals, and power calculations, and increased use of large multicenter databases, multivariate analyses, and bioinformatics. The complexity of clinical gastroenterology and hepatology research has increased dramatically, highlighting the need for advanced training of clinical investigators.

  20. Adapting practice-based intervention research to electronic environments: opportunities and complexities at two institutions.

    PubMed

    Stille, Christopher J; Lockhart, Steven A; Maertens, Julie A; Madden, Christi A; Darden, Paul M

    2015-01-01

    Primary care practice-based research has become more complex with increased use of electronic health records (EHRs). Little has been reported about changes in study planning and execution that are required as practices change from paper-based to electronic-based environments. We describe the evolution of a pediatric practice-based intervention study as it was adapted for use in the electronic environment, to enable other practice-based researchers to plan efficient, effective studies. We adapted a paper-based pediatric office-level intervention to enhance parent-provider communication about subspecialty referrals for use in two practice-based research networks (PBRNs) with partially and fully electronic environments. We documented the process of adaptation and its effect on study feasibility and efficiency, resource use, and administrative and regulatory complexities, as the study was implemented in the two networks. Considerable time and money was required to adapt the paper-based study to the electronic environment, requiring extra meetings with institutional EHR-, regulatory-, and administrative teams, and increased practice training. Institutional unfamiliarity with using EHRs in practice-based research, and the consequent need to develop new policies, were major contributors to delays. Adapting intervention tools to the EHR and minimizing practice disruptions was challenging, but resulted in several efficiencies as compared with a paper-based project. In particular, recruitment and tracking of subjects and data collection were easier and more efficient. Practice-based intervention research in an electronic environment adds considerable cost and time at the outset of a study, especially for centers unfamiliar with such research. Efficiencies generated have the potential of easing the work of study enrollment, subject tracking, and data collection.

  1. Embracing Complexity of Crop Phytobiomes with a Multidisciplinary Roadmap for Phytobiomes Research and an Industry-Academic Research Alliance

    NASA Astrophysics Data System (ADS)

    Eversole, K.

    2016-12-01

    To meet the demands of a global human population expected to exceed 9.6 billion by 2055, crop productivity in sustainable agricultural systems must improve considerably in the face of a steadily changing climate and increased biotic and abiotic stressors. Traditional agricultural sciences have relied mostly on research within individual disciplines and linear, reductionist approaches for crop improvement. While significant advancements have been made in developing and characterizing genetic and genomic resources for crops, we still have a very limited understanding of genotype by environment x management (GxExM) interactions that determine productivity, sustainability, quality, and the ability to withstand biotic and abiotic stressors. Embracing complexity and the non-linear organization and regulation of biological systems would enable a paradigm shift in breeding and crop production by allowing us to move towards a holistic, systems level approach that integrates a wide range of disciplines (e.g., geophysics, biology, agronomy, physiology, genomics, genetics, breeding, physics, pattern recognition, feedback loops, modeling, and engineering) and knowledge about crop phytobiomes (i.e., plants, their associated macro- and micro-organisms, and the geophysical environment of distinct geographical sites). By focusing on the phytobiome, we will be able to elucidate, quantify, model, predict, act, manipulate, and prevent and ultimately prescribe the cropping systems, methods, and management practices most suited for a particular farm, grassland, or forest. The recently released, multidisciplinary roadmap entitled Phytobiomes: A Roadmap for Research and Translation and the new International Alliance for Phytobiomes Research, an industry-academic consortium, will be presented.

  2. A complex systems science perspective for whole systems of complementary and alternative medicine research.

    PubMed

    Koithan, Mary; Bell, Iris R; Niemeyer, Kathryn; Pincus, David

    2012-01-01

    Whole systems complementary and alternative medicine (WS-CAM) approaches share a basic worldview that embraces interconnectedness; emergent, non-linear outcomes to treatment that include both local and global changes in the human condition; a contextual view of human beings that are inseparable from and responsive to their environments; and interventions that are complex, synergistic, and interdependent. These fundamental beliefs and principles run counter to the assumptions of reductionism and conventional biomedical research methods that presuppose unidimensional simple causes and thus dismantle and individually test various interventions that comprise only single aspects of the WSCAM system. This paper will demonstrate the superior fit and practical advantages of using complex adaptive systems (CAS) and related modeling approaches to develop the scientific basis for WS-CAM. Furthermore, the details of these CAS models will be used to provide working hypotheses to explain clinical phenomena such as (a) persistence of changes for weeks to months between treatments and/or after cessation of treatment, (b) nonlocal and whole systems changes resulting from therapy, (c) Hering's law, and (d) healing crises. Finally, complex systems science will be used to offer an alternative perspective on cause, beyond the simple reductionism of mainstream mechanistic ontology and more parsimonious than the historical vitalism of WS-CAM. Rather, complex systems science provides a scientifically rigorous, yet essentially holistic ontological perspective with which to conceptualize and empirically explore the development of disease and illness experiences, as well as experiences of healing and wellness.

  3. Using participatory action research in a community-based initiative addressing complex mental health needs.

    PubMed

    Knightbridge, Stephen M; King, Robert; Rolfe, Timothy J

    2006-04-01

    This paper describes the first phase of a larger project that utilizes participatory action research to examine complex mental health needs across an extensive group of stakeholders in the community. Within an objective qualitative analysis of focus group discussions the social ecological model is utilized to explore how integrative activities can be informed, planned and implemented across multiple elements and levels of a system. Seventy-one primary care workers, managers, policy-makers, consumers and carers from across the southern metropolitan and Gippsland regions of Victoria, Australia took part in seven focus groups. All groups responded to an identical set of focusing questions. Participants produced an explanatory model describing the service system, as it relates to people with complex needs, across the levels of social ecological analysis. Qualitative themes analysis identified four priority areas to be addressed in order to improve the system's capacity for working with complexity. These included: (i) system fragmentation; (ii) integrative case management practices; (iii) community attitudes; and (iv) money and resources. The emergent themes provide clues as to how complexity is constructed and interpreted across the system of involved agencies and interest groups. The implications these findings have for the development and evaluation of this community capacity-building project were examined from the perspective of constructing interventions that address both top-down and bottom-up processes.

  4. Research on Extraction of Ship Target in Complex Sea-sky Background

    NASA Astrophysics Data System (ADS)

    Kang, W. J.; Ding, X. M.; Cui, J. W.; Ao, L.

    2006-10-01

    Research on the extraction of ship target in complex sea-sky background has important value to improve the capability of imaging-typed sea navigation and nautical traffic control systems. According to the imaging property of complex sea-sky background, a reliable ship target extraction method is proposed in this paper. The general guide line is that getting the sea-sky division line as a priori knowledge and then the target potential area is determined through discontinuous region of the sea-sky division line. Firstly, a local selective window filter is adopted to filter the image; secondly, eight directions Sobel operator edge detection method and gradient Hough transform are combined to extract sea-sky division line in the image; then a multi-histogram matching technique is adopted to remove the sea and sky background and thus ship target is extracted from complex background. The experiments show that our method has the merits of robustness to noise, small computational complexity and stability.

  5. Diverse Complexities, Complex Diversities: Resisting "Normal Science" in Pedagogical and Research Methodologies. A Perspective from Aotearoa (New Zealand)

    ERIC Educational Resources Information Center

    Ritchie, Jenny

    2016-01-01

    This paper offers an overview of complexities of the contexts for education in Aotearoa, which include the need to recognise and include Maori (Indigenous) perspectives, but also to extend this inclusion to the context of increasing ethnic diversity. These complexities include the situation of worsening disparities between rich and poor which…

  6. Cardinal John Henry Newman and 'the ideal state and purpose of a university': nurse education, research and practice development for the twenty-first century.

    PubMed

    Rolfe, Gary

    2012-06-01

    Cardinal John Henry Newman's book, The Idea of a University, first published in the mid nineteenth century, is often invoked as the epitome of the liberal Enlightenment University in discussions and debates about the role and purpose of nurse education. In this article I will examine Newman's book in greater detail and with a more critical eye than is generally the case in the writing of nurse academics. In particular, I will focus on the claims that Newman was a champion of the Enlightenment University of the nineteenth century, that he promoted the idea of 'disinterested' universal knowledge for its own sake, that he was an early advocate of the pursuit of knowledge through scientific research, and the supposition that he would have welcomed the discipline of nursing into the University. In each case, I will suggest that these claims are based on an extremely selective reading of Newman's work. I will conclude by employing the example of practice development to propose an alternative way for nursing to find its place in the modern University that does not involve a retreat into what I will argue is an outdated and nostalgic view of the aims and purpose of higher education.

  7. Development of item bank to measure deliberate self-harm behaviours: facilitating tailored scales and computer adaptive testing for specific research and clinical purposes.

    PubMed

    Latimer, Shane; Meade, Tanya; Tennant, Alan

    2014-07-30

    The purpose of this study was to investigate the application of item banking to questionnaire items intended to measure Deliberate Self-Harm (DSH) behaviours. The Rasch measurement model was used to evaluate behavioural items extracted from seven published DSH scales administered to 568 Australians aged 18-30 years (62% university students, 21% mental health patients, and 17% community members). Ninety four items were calibrated in the item bank (including 12 items with differential item functioning for gender and age). Tailored scale construction was demonstrated by extracting scales covering different combinations of DSH methods but with the same raw score for each person location on the latent DSH construct. A simulated computer adaptive test (starting with common self-harm methods to minimise presentation of extreme behaviours) demonstrated that 11 items (on average) were needed to achieve a standard error of measurement of 0.387 (corresponding to a Cronbach׳s Alpha of 0.85). This study lays the groundwork for advancing DSH measurement to an item bank approach with the flexibility to measure a specific definitional orientation (e.g., non-suicidal self-injury) or a broad continuum of self-harmful acts, as appropriate to a particular research/clinical purpose. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  8. [Researches on genetics and genetic epidemiology of common complex diseases: challenge and strategies].

    PubMed

    Gu, Dong-feng

    2006-04-01

    With the rapid development of human genome project, increased genetic and population-based association studies are focused on the identification of the underlying susceptibility genes and contributions from gene-environment interaction to common complex diseases. Whole-genome association study with high-density single nucleotide polymorphisms is one of the most important milestones in that process. However, problems still exist in study design, data processing, and results interpretation. Large-scale cohort study or population-based case-control design with sufficient statistical power, new approaches to assess the gene-gene and gene-environment interactions, as guarantee of the consistency and replicability of these researches are crucial in the exploration of the causes of these common complex diseases.

  9. Real-Gas Flow Properties for NASA Langley Research Center Aerothermodynamic Facilities Complex Wind Tunnels

    NASA Technical Reports Server (NTRS)

    Hollis, Brian R.

    1996-01-01

    A computational algorithm has been developed which can be employed to determine the flow properties of an arbitrary real (virial) gas in a wind tunnel. A multiple-coefficient virial gas equation of state and the assumption of isentropic flow are used to model the gas and to compute flow properties throughout the wind tunnel. This algorithm has been used to calculate flow properties for the wind tunnels of the Aerothermodynamics Facilities Complex at the NASA Langley Research Center, in which air, CF4. He, and N2 are employed as test gases. The algorithm is detailed in this paper and sample results are presented for each of the Aerothermodynamic Facilities Complex wind tunnels.

  10. Behavior of complex mixtures in aquatic environments: a synthesis of PNL ecological research

    SciTech Connect

    Fickeisen, D.H.; Vaughan, B.E.

    1984-06-01

    The term complex mixture has been recently applied to energy-related process streams, products and wastes that typically contain hundreds or thousands of individual organic compounds, like petroleum or synthetic fuel oils; but it is more generally applicable. A six-year program of ecological research has focused on four areas important to understanding the environmental behavior of complex mixtures: physicochemical variables, individual organism responses, ecosystems-level determinations, and metabolism. Of these areas, physicochemical variables and organism responses were intensively studied; system-level determinations and metabolism represent more recent directions. Chemical characterization was integrated throughout all areas of the program, and state-of-the-art methods were applied. 155 references, 35 figures, 4 tables.

  11. Researching Complex and Multi-Level Workplace Factors Affecting Disability and Prolonged Sickness Absence.

    PubMed

    Kristman, Vicki L; Shaw, William S; Boot, Cécile R L; Delclos, George L; Sullivan, Michael J; Ehrhart, Mark G

    2016-12-01

    Purpose There is growing research evidence that workplace factors influence disability outcomes, but these variables reflect a variety of stakeholder perspectives, measurement tools, and methodologies. The goal of this article is to summarize existing research of workplace factors in relation to disability, compare this with employer discourse in the grey literature, and recommend future research priorities. Methods The authors participated in a year-long collaboration that ultimately led to an invited 3-day conference, "Improving Research of Employer Practices to Prevent Disability, held October 14-16, 2015, in Hopkinton, Massachusetts, USA. The collaboration included a topical review of the literature, group conference calls to identify key areas and challenges, drafting of initial documents, review of industry publications, and a conference presentation that included feedback from peer researchers and a question/answer session with a special panel of knowledge experts with direct employer experience. Results Predominant factors in the scientific literature were categorized as physical or psychosocial job demands, work organization and support, and workplace beliefs and attitudes. Employees experiencing musculoskeletal disorders in large organizations were the most frequently studied population. Research varied with respect to the basic unit of assessment (e.g., worker, supervisor, policy level) and whether assessments should be based on worker perceptions, written policies, or observable practices. The grey literature suggested that employers focus primarily on defining roles and responsibilities, standardizing management tools and procedures, being prompt and proactive, and attending to the individualized needs of workers. Industry publications reflected a high reliance of employers on a strict biomedical model in contrast to the more psychosocial framework that appears to guide research designs. Conclusion Assessing workplace factors at multiple levels, within

  12. The complexities of air pollution regulation: the need for an integrated research and regulatory perspective.

    PubMed

    Nadadur, Srikanth S; Miller, C Andrew; Hopke, Philip K; Gordon, Terry; Vedal, Sverre; Vandenberg, John J; Costa, Daniel L

    2007-12-01

    The Clean Air Act mandates the U.S. Environmental Protection Agency to periodically reassess existing and new science that underlie the regulation of major ambient pollutants -- particulate matter (PM) and tropospheric ozone being most notable. While toxic effects have been ascribed individually to these and other pollutants in the air, it is clear that mixtures of these contaminants have the potential to interact and thereby influence their overall toxic outcomes. It follows that a more comprehensive assessment of the potential health effects of the air pollution complex might better protect human health; however, traditional regulatory drivers and funding constraints have impeded progress to such a goal. Despite difficulties in empirically conducting studies of complex mixtures of air pollutants and acquiring relevant exposure data, there remains a need to develop integrated, interdisciplinary research and analytical strategies to provide more comprehensive (and relevant) assessments of associated health outcomes and risks. The research and assessment communities are endeavoring to dissect this complexity using varied approaches Here we present five interdisciplinary perspectives of this evolving line of thought among researchers and those who use such data in assessment: (1) analyses that coordinate air quality-health analyses utilizing representative polluted U.S. air sheds to apportion source and component-specific health risks; (2) novel approaches to characterize air quality in terms of emission sources and how emission reduction strategies might effectively impact pollutant levels; (3) insights from present-day studies of effects of single ambient pollutants in animal and controlled clinical toxicology studies and how these are evolving to address air pollution; (4) refinements in epidemiologic health assessments that take advantage of the complexities of existent air quality conditions; and (5) new approaches to integrative analyses to establish the

  13. Research of complex loading of polycrystals with consideration for internal structure evolution

    NASA Astrophysics Data System (ADS)

    Loevets, Dmitry A.; Volegov, Pavel S.

    2016-11-01

    The paper discusses some questions related to the description of inelastic deformation of the representative volume of polycrystals with consideration for the evolution of its internal structure as well as to the study of the stress "dive" effect occurring at the complex deformation trajectories with a kink. For research, we use a two-level model of inelastic deformation of the representative volume of polycrystals and the analysis of the results performed using the approach of the Ilyushin theory to elastoplastic processes. According to the results of numerical experiments, it is established the relation between hardening parameters of the two-level model and the degree of manifestation of the stress "dive" effect.

  14. Collaborative Research. Damage and Burst Dynamics in Failure of Complex Geomaterials. A Statistical Physics Approach to Understanding the Complex Emergent Dynamics in Near Mean-Field Geological Materials

    SciTech Connect

    Rundle, John B.; Klein, William

    2015-09-29

    We have carried out research to determine the dynamics of failure in complex geomaterials, specifically focusing on the role of defects, damage and asperities in the catastrophic failure processes (now popularly termed “Black Swan events”). We have examined fracture branching and flow processes using models for invasion percolation, focusing particularly on the dynamics of bursts in the branching process. We have achieved a fundamental understanding of the dynamics of nucleation in complex geomaterials, specifically in the presence of inhomogeneous structures.

  15. Regeneration of tissues of the oral complex: current clinical trends and research advances.

    PubMed

    Nguyen, Thomas T; Mui, Brennan; Mehrabzadeh, Mahsa; Chea, Yannie; Chaudhry, Zoya; Chaudhry, Kamran; Tran, Simon D

    2013-01-01

    Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.

  16. Purpose Plus: Supporting Youth Purpose, Control, and Academic Achievement

    ERIC Educational Resources Information Center

    Pizzolato, Jane Elizabeth; Brown, Elizabeth Levine; Kanny, Mary Allison

    2011-01-01

    Research in the past decade suggests that a persistent achievement gap between students from low-income minority backgrounds and higher-income white backgrounds may be rooted in theories of student motivation and youth purpose. Yet limited research exists regarding the role of purpose on positive youth development as it pertains to academic…

  17. Purpose Plus: Supporting Youth Purpose, Control, and Academic Achievement

    ERIC Educational Resources Information Center

    Pizzolato, Jane Elizabeth; Brown, Elizabeth Levine; Kanny, Mary Allison

    2011-01-01

    Research in the past decade suggests that a persistent achievement gap between students from low-income minority backgrounds and higher-income white backgrounds may be rooted in theories of student motivation and youth purpose. Yet limited research exists regarding the role of purpose on positive youth development as it pertains to academic…

  18. The essence of life purpose.

    PubMed

    Hodges, Pamela J

    2009-01-01

    Life purpose is an important thread of critical care nursing. However, no consensus exists for a definition of life purpose. In addition, ambiguity prevails regarding the manner in which life purpose is incorporated into nursing practice and research. Therefore, through a conceptual synthesis process, this article aims to clarify the essence of life purpose with relevance to health and critical care nursing today. The outcome of the conceptual synthesis is an operational definition to be used in future nursing research. Information was obtained from a literature search of scholarly articles using (1) searches of electronic databases of literature about life purpose and (2) research studies addressing conceptual, substantive, and methodological domains. Topics consisted of the philosophical underpinnings of life purpose, its attributes, definitions, and theoretical frameworks, along with differences in theories and empirical support. Finally, emerging from this process, the article culminates with a proposed conceptual definition of life purpose, which may be applied broadly to older adults in various critical care settings.

  19. The Einstein Observatory: A New Public/Private Observatory Complex for Community Education and Scientific Research

    NASA Astrophysics Data System (ADS)

    Sowell, J.

    1999-12-01

    The Development Authority of Cherokee County (Georgia) is leading a public/private partnership of business/industry professionals, educators, and university scientists that seeks to develop a national prototype educational and scientific research facility for grades K-12, as well as college-level research, that will inspire our youth to become literate in science and technology. In particular, the goal is to make this complex a science, math, and engineering magnet learning facility and to raise the average SAT scores of local area students by 100 points. A dark-site mountain, nestled on the foothills of the Blue Ridge Mountains at the northern-most edge of Atlanta, will become the home for the "Einstein" Observatory. The complex will have four telescopes: one 50-inch, one 24-inch, and two 16-inch telescopes. Each telescope will have digital cameras and an optic-fiber feed to a single, medium-resolution spectroscope. All four telescopes will be electronically accessible from local schools. Professional astronomers will establish suitable observational research projects and will lead K-12 and college students in the acquisition and analysis of data. Astronomers will also assist the local area schoolteachers in methods for nurturing children's scientific inquiry. The observatory mountain will have 100 platform locations for individual viewing by visiting families, school groups, and amateur astronomers. The Atlanta Astronomer Club will provide numerous evening programs and viewing opportunities for the general public. An accompanying Planetarium & Science Center will be located on the nearby campus of Reinhardt College. The Planetarium & Science Center will be integrated with Reinhardt College's theme of learning focused upon studying the past and present as a basis for projecting the future.

  20. Generating Automated Text Complexity Classifications That Are Aligned with Targeted Text Complexity Standards. Research Report. ETS RR-10-28

    ERIC Educational Resources Information Center

    Sheehan, Kathleen M.; Kostin, Irene; Futagi, Yoko; Flor, Michael

    2010-01-01

    The Common Core Standards call for students to be exposed to a much greater level of text complexity than has been the norm in schools for the past 40 years. Textbook publishers, teachers, and assessment developers are being asked to refocus materials and methods to ensure that students are challenged to read texts at steadily increasing…

  1. The Use of Complex Adaptive Systems as a Generative Metaphor in an Action Research Study of an Organisation

    ERIC Educational Resources Information Center

    Brown, Callum

    2008-01-01

    Understanding the dynamic behaviour of organisations is challenging and this study uses a model of complex adaptive systems as a generative metaphor to address this challenge. The research question addressed is: How might a conceptual model of complex adaptive systems be used to assist in understanding the dynamic nature of organisations? Using an…

  2. The Use of Complex Adaptive Systems as a Generative Metaphor in an Action Research Study of an Organisation

    ERIC Educational Resources Information Center

    Brown, Callum

    2008-01-01

    Understanding the dynamic behaviour of organisations is challenging and this study uses a model of complex adaptive systems as a generative metaphor to address this challenge. The research question addressed is: How might a conceptual model of complex adaptive systems be used to assist in understanding the dynamic nature of organisations? Using an…

  3. Multiple and Complex Needs: Researching the Views of Pupils with Multiple and Complex Needs. Is It Worth Doing and Whose Interests Are Served by It?

    ERIC Educational Resources Information Center

    Wright, Kevin

    2008-01-01

    Because of what are perceived by some as potential challenges it is still commonplace for research to fail to seek the opinions of pupils with multiple and complex needs. While many such pupils do have significant communication difficulties, along with other disabilities, which are undoubtedly a constraint, it is crucial in order to be inclusive,…

  4. Enriching gender in physics education research: A binary past and a complex future

    NASA Astrophysics Data System (ADS)

    Traxler, Adrienne

    2017-01-01

    This talk draws on research in physics, science education, and women's studies to propose a more nuanced treatment of gender in physics education research (PER). A growing body of PER has examined gender differences in students' participation, performance, and attitudes toward physics. Though valuable, this body of work often follows a ``binary deficit'' model of gender, where the achievements of men are implicitly taken as the most appropriate standard and where individual experiences and student identities are undervalued. I will discuss more up-to-date viewpoints on gender from other fields, as well as work on the intersection of identities [e.g., gender with race and ethnicity, or with lesbian, gay, bisexual, and transgender (LGBT) status]. A few PER studies examine the intersection of gender and race, and identify the lack of a unitary identity as a key challenge of ``belonging'' in physics. Acknowledging this complexity of identity allows further critique of the binary deficit model, which casts gender as a fixed binary trait and frames research questions around investigating deficiencies in women rather than issues of systemic bias. More nuanced models of gender allow a greater range and fluidity of gender identities, and highlight deficiencies in data that exclude women's experiences. I will conclude by suggesting new investigations that might build on an expanded gender framework in PER.

  5. NCAR's Research Data Archive: OPeNDAP Access for Complex Datasets

    NASA Astrophysics Data System (ADS)

    Dattore, R.; Worley, S. J.

    2014-12-01

    Many datasets have complex structures including hundreds of parameters and numerous vertical levels, grid resolutions, and temporal products. Making these data accessible is a challenge for a data provider. OPeNDAP is powerful protocol for delivering in real-time multi-file datasets that can be ingested by many analysis and visualization tools, but for these datasets there are too many choices about how to aggregate. Simple aggregation schemes can fail to support, or at least make it very challenging, for many potential studies based on complex datasets. We address this issue by using a rich file content metadata collection to create a real-time customized OPeNDAP service to match the full suite of access possibilities for complex datasets. The Climate Forecast System Reanalysis (CFSR) and it's extension, the Climate Forecast System Version 2 (CFSv2) datasets produced by the National Centers for Environmental Prediction (NCEP) and hosted by the Research Data Archive (RDA) at the Computational and Information Systems Laboratory (CISL) at NCAR are examples of complex datasets that are difficult to aggregate with existing data server software. CFSR and CFSv2 contain 141 distinct parameters on 152 vertical levels, six grid resolutions and 36 products (analyses, n-hour forecasts, multi-hour averages, etc.) where not all parameter/level combinations are available at all grid resolution/product combinations. These data are archived in the RDA with the data structure provided by the producer; no additional re-organization or aggregation have been applied. Since 2011, users have been able to request customized subsets (e.g. - temporal, parameter, spatial) from the CFSR/CFSv2, which are processed in delayed-mode and then downloaded to a user's system. Until now, the complexity has made it difficult to provide real-time OPeNDAP access to the data. We have developed a service that leverages the already-existing subsetting interface and allows users to create a virtual dataset

  6. Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding Future Research: A Case Study Involving the Oral Carcinogenicity of Hexavalent Chromium

    PubMed Central

    Thompson, Chad M.; Haws, Laurie C.; Harris, Mark A.; Gatto, Nicole M.; Proctor, Deborah M.

    2011-01-01

    Mode of action (MOA) analysis provides a systematic description of key events leading to adverse health effects in animal bioassays for the purpose of informing human health risk assessment. Uncertainties and data gaps identified in the MOA analysis may also be used to guide future research to improve understanding of the MOAs underlying a specific toxic response and foster development of toxicokinetic and toxicodynamic models. An MOA analysis, consistent with approaches outlined in the MOA Framework as described in the Guidelines for Carcinogen Risk Assessment, was conducted to evaluate small intestinal tumors observed in mice chronically exposed to relatively high concentrations of hexavalent chromium (Cr(VI)) in drinking water. Based on review of the literature, key events in the MOA are hypothesized to include saturation of the reductive capacity of the upper gastrointestinal tract, absorption of Cr(VI) into the intestinal epithelium, oxidative stress and inflammation, cell proliferation, direct and/or indirect DNA modification, and mutagenesis. Although available data generally support the plausibility of these key events, several unresolved questions and data gaps were identified, highlighting the need for obtaining critical toxicokinetic and toxicodynamic data in the target tissue and in the low-dose range. Experimental assays that can address these data gaps are discussed along with strategies for comparisons between responsive and nonresponsive tissues and species. This analysis provides a practical application of MOA Framework guidance and is instructive for the design of studies to improve upon the information available for quantitative risk assessment. PMID:20947717

  7. 7 CFR 3430.501 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Integrated Research, Education, and Extension Competitive Grants Program § 3430.501 Purpose. The purpose of this subpart is to make competitive grants for integrated, multifunctional agricultural...

  8. 7 CFR 3430.501 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Integrated Research, Education, and Extension Competitive Grants Program § 3430.501 Purpose. The purpose of this subpart is to make competitive grants for integrated, multifunctional agricultural...

  9. 7 CFR 3430.501 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Integrated Research, Education, and Extension Competitive Grants Program § 3430.501 Purpose. The purpose of this subpart is to make competitive grants for integrated, multifunctional agricultural...

  10. 7 CFR 3430.501 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Integrated Research, Education, and Extension Competitive Grants Program § 3430.501 Purpose. The purpose of this subpart is to make competitive grants for integrated, multifunctional agricultural...

  11. Social epidemiology and complex system dynamic modelling as applied to health behaviour and drug use research

    PubMed Central

    Galea, Sandro; Hall, Chris; Kaplan, George A

    2009-01-01

    A social epidemiologic perspective considers factors at multiple levels of influence (e.g., social networks, neighborhoods, states) that may individually or jointly affect health and health behaviour. This provides a useful lens through which to understand the production of health behaviours in general, and drug use in particular. However, the analytic models that are commonly applied in population health sciences limit the inference we are able to draw about the determination of health behaviour by factors, likely interrelated, across levels of influence. Complex system dynamic modelling techniques may be useful in enabling the adoption of a social epidemiologic approach in health behaviour and drug use research. We provide an example of a model that aims to incorporate factors at multiple levels of influence in understanding drug dependence. We conclude with suggestions about future directions in the field and how such models may serve as virtual laboratories for policy experiments aimed at improving health behaviour. PMID:18930649

  12. Complex PTSD: research directions for nosology/assessment, treatment, and public health

    PubMed Central

    Ford, Julian D.

    2015-01-01

    Complex posttraumatic stress disorder (CPTSD) in children and adolescents extends beyond the core PTSD symptoms to dysregulation in three psychobiological domains: (1) emotion processing, (2) self-organization (including bodily integrity), and (3) relational functioning. CPTSD research directions for the next decade and beyond are identified in three areas: (1) diagnostic classification (establishing the empirical integrity of CPTSD as a distinct form of psychopathology) and psychometric assessment [validation and refinement of measures of childhood polyvictimization and developmental trauma disorder (DTD)], (2) rigorous evaluation and refinement of interventions (and algorithms for their delivery) developed or adapted for CPTSD and DTD, and (3) the epidemiology of CPTSD and DTD, and their public health and safety impact, across the lifespan and intergenerationally, for populations, nations, and cultures. PMID:25994023

  13. Social epidemiology and complex system dynamic modelling as applied to health behaviour and drug use research.

    PubMed

    Galea, Sandro; Hall, Chris; Kaplan, George A

    2009-05-01

    A social epidemiologic perspective considers factors at multiple levels of influence (e.g., social networks, neighbourhoods, states) that may individually or jointly affect health and health behaviour. This provides a useful lens through which to understand the production of health behaviours in general, and drug use in particular. However, the analytic models that are commonly applied in population health sciences limit the inference we are able to draw about the determination of health behaviour by factors, likely interrelated, across levels of influence. Complex system dynamic modelling techniques may be useful in enabling the adoption of a social epidemiologic approach in health behaviour and drug use research. We provide an example of a model that aims to incorporate factors at multiple levels of influence in understanding drug dependence. We conclude with suggestions about future directions in the field and how such models may serve as virtual laboratories for policy experiments aimed at improving health behaviour.

  14. Systems Engineering Design Via Experimental Operation Research: Complex Organizational Metric for Programmatic Risk Environments (COMPRE)

    NASA Technical Reports Server (NTRS)

    Mog, Robert A.

    1999-01-01

    Unique and innovative graph theory, neural network, organizational modeling, and genetic algorithms are applied to the design and evolution of programmatic and organizational architectures. Graph theory representations of programs and organizations increase modeling capabilities and flexibility, while illuminating preferable programmatic/organizational design features. Treating programs and organizations as neural networks results in better system synthesis, and more robust data modeling. Organizational modeling using covariance structures enhances the determination of organizational risk factors. Genetic algorithms improve programmatic evolution characteristics, while shedding light on rulebase requirements for achieving specified technological readiness levels, given budget and schedule resources. This program of research improves the robustness and verifiability of systems synthesis tools, including the Complex Organizational Metric for Programmatic Risk Environments (COMPRE).

  15. Assessing the evaluability of complex public health interventions: five questions for researchers, funders, and policymakers.

    PubMed

    Ogilvie, David; Cummins, Steven; Petticrew, Mark; White, Martin; Jones, Andy; Wheeler, Kathryn

    2011-06-01

    Evidence to support government programs to improve public health often is weak. Recognition of this "knowledge gap" has led to calls for more and better evaluation, but decisions about priorities for evaluation also need to be addressed in regard to financial restraint. Using England's Healthy Community Challenge Fund as a case study, this article presents a set of questions to stimulate and structure debate among researchers, funders, and policymakers and help make decisions about evaluation within and between complex public health interventions as they evolve from initial concept to dissemination of full-scale intervention packages. This approach can be used to identify the types of knowledge that might be generated from any evaluation, given the strength of evidence available in response to each of five questions, and to support a more systematic consideration of resource allocation decisions, depending on the types of knowledge required. The principles of this approach may be generalizable, and should be tested and refined for other complex public health and wider social interventions. © 2011 Milbank Memorial Fund. Published by Wiley Periodicals Inc.

  16. Calibration of Cosmic Ray Neutron Probes in complex systems: open research issues

    NASA Astrophysics Data System (ADS)

    Piussi, Laura; Tomelleri, Enrico; Bertoldi, Giacomo; Zebisch, Marc; Niedrist, Georg; Tonon, Giustino

    2017-04-01

    Soil moisture is a key variable for environmental monitoring, hydrological and climate change research as it controls mass and energy fluxes in the soil-plant-atmosphere continuum. Actual soil moisture monitoring methods are capable of providing observations either at a very big spatial scale and timely spotty satellite observations or at a very small scale and timely continuous point measurements. In this framework, meso-scale timely continuous measurements appear of key relevance, thus, recently, Cosmic Ray Neutron Sensing (CRNS) is gaining more and more importance, because of its capacity to deliver long time-series of observations within a footprint of 500m of diameter. Even if during the last years a remarkable number of papers have been published, the calibration of Cosmic Ray Neutron Probes (CRPs) in heterogeneous ecosystems is still an open issue. The CRP is sensitive to all the Hydrogen species and their distribution within the footprint, thus in environments that can be assumed as homogeneous a good accordance between the CRNS data and observed soil moisture can be reached, but, where Hydrogen distributions are complex, different calibration campaigns lead to different results. In order to improve the efficiency of the method, a better understanding of the effects of combined spatial and temporal variability has to be reached. The aim of the actual work is to better understand the effects of multiple Hydrogen sources that vary in time and space and evaluate different approaches in calibration over complex terrain in a mountain area. We present different calibration approaches used for an alpine pasture, which is a research site of the LTER network in South-Tyrol (Italy). In the study site long-term soil moisture observations are present and are used for remote-sensing data validation. For this specific and highly heterogeneous site, the effects of heterogeneous land-cover and topography on CRP calibration are evaluated and some hypotheses on the major

  17. Rapid qualitative research methods during complex health emergencies: A systematic review of the literature.

    PubMed

    Johnson, Ginger A; Vindrola-Padros, Cecilia

    2017-09-01

    The 2013-2016 Ebola outbreak in West Africa highlighted both the successes and limitations of social science contributions to emergency response operations. An important limitation was the rapid and effective communication of study findings. A systematic review was carried out to explore how rapid qualitative methods have been used during global heath emergencies to understand which methods are commonly used, how they are applied, and the difficulties faced by social science researchers in the field. We also asses their value and benefit for health emergencies. The review findings are used to propose recommendations for qualitative research in this context. Peer-reviewed articles and grey literature were identified through six online databases. An initial search was carried out in July 2016 and updated in February 2017. The PRISMA checklist was used to guide the reporting of methods and findings. The articles were assessed for quality using the MMAT and AACODS checklist. From an initial search yielding 1444 articles, 22 articles met the criteria for inclusion. Thirteen of the articles were qualitative studies and nine used a mixed-methods design. The purpose of the rapid studies included: the identification of causes of the outbreak, and assessment of infrastructure, control strategies, health needs and health facility use. The studies varied in duration (from 4 days to 1 month). The main limitations identified by the authors were: the low quality of the collected data, small sample sizes, and little time for cross-checking facts with other data sources to reduce bias. Rapid qualitative methods were seen as beneficial in highlighting context-specific issues that need to be addressed locally, population-level behaviors influencing health service use, and organizational challenges in response planning and implementation. Recommendations for carrying out rapid qualitative research in this context included the early designation of community leaders as a point of

  18. 75 FR 16149 - Notice Of Amendment-OS ARRA Expansion of Research Capabilities To Study CE Complex Patients (R24...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Notice Of Amendment--OS ARRA Expansion of Research Capabilities To Study CE Complex Patients (R24) SEP Meeting With this correction notice,...

  19. Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research

    PubMed Central

    Michel, Maximilian; Lyons, Lisa C.

    2014-01-01

    Across phylogeny, the endogenous biological clock has been recognized as providing adaptive advantages to organisms through coordination of physiological and behavioral processes. Recent research has emphasized the role of circadian modulation of memory in generating peaks and troughs in cognitive performance. The circadian clock along with homeostatic processes also regulates sleep, which itself impacts the formation and consolidation of memory. Thus, the circadian clock, sleep and memory form a triad with ongoing dynamic interactions. With technological advances and the development of a global 24/7 society, understanding the mechanisms underlying these connections becomes pivotal for development of therapeutic treatments for memory disorders and to address issues in cognitive performance arising from non-traditional work schedules. Invertebrate models, such as Drosophila melanogaster and the mollusks Aplysia and Lymnaea, have proven invaluable tools for identification of highly conserved molecular processes in memory. Recent research from invertebrate systems has outlined the influence of sleep and the circadian clock upon synaptic plasticity. In this review, we discuss the effects of the circadian clock and sleep on memory formation in invertebrates drawing attention to the potential of in vivo and in vitro approaches that harness the power of simple invertebrate systems to correlate individual cellular processes with complex behaviors. In conclusion, this review highlights how studies in invertebrates with relatively simple nervous systems can provide mechanistic insights into corresponding behaviors in higher organisms and can be used to outline possible therapeutic options to guide further targeted inquiry. PMID:25136297

  20. Dynamic Systems (Complexity) theory as a new conceptual model for researching PBL in dental education.

    PubMed

    Townsend, G C; Kim, M; Sankey, D

    2012-02-01

    Although problem-based learning (PBL) was introduced into dental education some 20 years ago, there have been relatively few well-designed studies carried out to clarify whether, how or why it works in a dental context. This paper introduces the Dynamic Systems (Complexity) theory as a new and potentially productive theoretical framework for researching PBL in dental education. This framework emphasises the importance of emergent self-organisation, perception and brain plasticity in learning. In this paper, a brief overview of the history of PBL in dentistry is presented and then the fundamentals of a Dynamic Systems Approach (DSA) are explained, drawing on two recently published papers advocating the DSA in medical education and teacher education. We focus on three key points related to this new approach: emergent self-organisation rather than simple construction of knowledge; the notion that perception drives the learning process; and the brain as the substrate of all learning. The paper also suggests how the DSA can help us move forward, both in terms of the future application of PBL in dental education and also in relation to posing new types of research questions.

  1. THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX AS A PARADIGM IN GENOMICS RESEARCH

    PubMed Central

    Vandiedonck, Claire; Knight, Julian C

    2010-01-01

    Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in numerous diseases, the MHC has been considered as a model region for genomics, being the first substantial region to be sequenced and establishing fundamental concepts of linkage disequilibrium, haplotypic structure and meiotic recombination. Recently, the MHC became the first genomic region to be entirely re-sequenced for common haplotypes, while studies mapping gene expression phenotypes across the genome have strongly implicated variation in the MHC. This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics. PMID:19468039

  2. Dealing with complexity in research processes and findings: how do older women negotiate and challenge images of aging?

    PubMed

    Hogan, Susan; Warren, Lorna

    2012-01-01

    The Representing Self-Representing Ageing initiative has been funded by the ESRC as part of the New Dynamics of Ageing cross-council research program. It has consisted of four projects with older women using visual research methods and participatory approaches to enable women to articulate their experiences of aging and to create alternative images of aging. Complex research processes were utilized. Innovative methods included the use of art elicitation, photo diaries, film booths, and phototherapy.

  3. Realist complex intervention science: Applying realist principles across all phases of the Medical Research Council framework for developing and evaluating complex interventions

    PubMed Central

    Fletcher, Adam; Jamal, Farah; Moore, Graham; Evans, Rhiannon E.; Murphy, Simon; Bonell, Chris

    2016-01-01

    The integration of realist evaluation principles within randomised controlled trials (‘realist RCTs’) enables evaluations of complex interventions to answer questions about what works, for whom and under what circumstances. This allows evaluators to better develop and refine mid-level programme theories. However, this is only one phase in the process of developing and evaluating complex interventions. We describe and exemplify how social scientists can integrate realist principles across all phases of the Medical Research Council framework. Intervention development, modelling, and feasibility and pilot studies need to theorise the contextual conditions necessary for intervention mechanisms to be activated. Where interventions are scaled up and translated into routine practice, realist principles also have much to offer in facilitating knowledge about longer-term sustainability, benefits and harms. Integrating a realist approach across all phases of complex intervention science is vital for considering the feasibility and likely effects of interventions for different localities and population subgroups. PMID:27478401

  4. The contribution of qualitative research in designing a complex intervention for secondary prevention of coronary heart disease in two different healthcare systems

    PubMed Central

    Corrrigan, Mairead; Cupples, Margaret E; Smith, Susan M; Byrne, Molly; Leathem, Claire S; Clerkin, Pauline; Murphy, Andrew W

    2006-01-01

    Background Developing complex interventions for testing in randomised controlled trials is of increasing importance in healthcare planning. There is a need for careful design of interventions for secondary prevention of coronary heart disease (CHD). It has been suggested that integrating qualitative research in the development of a complex intervention may contribute to optimising its design but there is limited evidence of this in practice. This study aims to examine the contribution of qualitative research in developing a complex intervention to improve the provision and uptake of secondary prevention of CHD within primary care in two different healthcare systems. Methods In four general practices, one rural and one urban, in Northern Ireland and the Republic of Ireland, patients with CHD were purposively selected. Four focus groups with patients (N = 23) and four with staff (N = 29) informed the development of the intervention by exploring how it could be tailored and integrated with current secondary prevention activities for CHD in the two healthcare settings. Following an exploratory trial the acceptability and feasibility of the intervention were discussed in four focus groups (17 patients) and 10 interviews (staff). The data were analysed using thematic analysis. Results Integrating qualitative research into the development of the intervention provided depth of information about the varying impact, between the two healthcare systems, of different funding and administrative arrangements, on their provision of secondary prevention and identified similar barriers of time constraints, training needs and poor patient motivation. The findings also highlighted the importance to patients of stress management, the need for which had been underestimated by the researchers. The qualitative evaluation provided depth of detail not found in evaluation questionnaires. It highlighted how the intervention needed to be more practical by minimising administration, integrating

  5. Advanced recycling and research complexes: A second strategic use for installations on the base closure list

    SciTech Connect

    Walter, D.W.; Kuusinen, T.L.; Beck, J.E.

    1993-05-01

    Obstacles currently facing the solid waste recycling industry are often related to a lack of public and investor confidence, issues of profitability and liability, and insufficient consumer identification with products made from recycled materials. Resolution of these issues may not be possible without major changes in the way the solid waste recycling business is structured. At the same time, we are faced with opportunities which will not likely recur in our lifetimes: access to educated, well trained work forces; and large tracts of land that are contiguous with metropolitan areas and are developed for heavy industry and transportation. Military installations are being converted to civilian use just in time to serve as important a role in our national resource conservation policy. The future of recycling in North America converges with the future of selected bases on the closure list and takes the form of converting these bases into Advanced Recycling and Research Complexes. The premise is simple: use these strategically-located facilities as industrial parks where a broad range of secondary wastes are separated, refined, or converted and made into new products on site. The wastes would include municipal solid waste (MSW), demolition waste, landscape trimmings, used tires, scrap metal, agricultural waste, food processing waste, and other non-hazardous materials. The park would consist of separation and conversion facilities, research and product standards laboratories, and industries that convert the materials into products and fuels. Energy conversion systems using some waste streams as fuel could be located at the park to supplement energy demands of the industrial operations. The strategic co-location of the resource providers and user industries would minimize transportation costs.

  6. Handling Complexity in Learning Environments: Theory and Research. Advances in Learning and Instruction

    ERIC Educational Resources Information Center

    Elen, Jan, Ed.; Clark, Richard, Ed.

    2006-01-01

    What is meant when people say that "learning environments are increasingly complex"? What is known about the cognitive processing that occurs during complex learning? How can educators provide effective instructional support for students who must learn and apply complex knowledge? These questions, and related issues, have fascinated educators and…

  7. Handling Complexity in Learning Environments: Theory and Research. Advances in Learning and Instruction

    ERIC Educational Resources Information Center

    Elen, Jan, Ed.; Clark, Richard, Ed.

    2006-01-01

    What is meant when people say that "learning environments are increasingly complex"? What is known about the cognitive processing that occurs during complex learning? How can educators provide effective instructional support for students who must learn and apply complex knowledge? These questions, and related issues, have fascinated educators and…

  8. Embracing Complexity: Findings from a Comparative Analysis of Representations of Teachers in the British Press and Research Literature

    ERIC Educational Resources Information Center

    Zemke, Emily

    2007-01-01

    This paper follows an empirical study of how teachers were represented in British newspapers during the 1990s. Its purpose is to describe some of the findings arising from a comparison of the data and representations of teachers in educational research literature. The topic of teacher representation was a matter of personal interest to the…

  9. Serodiagnosis of Mycobacterium avium complex disease in humans: translational research from basic mycobacteriology to clinical medicine.

    PubMed

    Kobayashi, Kazuo

    2014-01-01

    Rapid and accurate diagnosis of infectious diseases, including mycobacterial disease such as tuberculosis (TB) and diseases due to nontuberculous mycobacteria (NTM), is a very important element of global health. The gold standard in diagnosis of mycobacterial diseases remains clinical examination, combined with direct microscopic examination of sputum and culture of bacteria. Culture of slowly growing mycobacteria, including Mycobacterium tuberculosis and NTM (such as M. avium complex: MAC), can take up to 4 to 6 weeks, and in 10-20% of cases the bacillus is not successfully cultivated. Diagnosis of MAC pulmonary disease (MAC-PD) is complicated and time-consuming (usually at least 1 month). I have characterized the nature of MAC antigens and immune responses from the aspect of basic mycobacteriology, and then translated to clinical science. My multicenter study in Japan has demonstrated the usefulness of a serodiagnostic test to determine serum IgA antibodies against mycobacterial glycopeptidolipid (GPL) core antigen for diagnosing MAC-PD within a few hours. To validate in a larger number of patients, at diverse geographic locations, and among other races, the test was also assessed the usefulness internationally in the United States and Taiwan. In this review, I discuss development of serodiagnosis of MAC-PD by translational research and international collaboration study.

  10. PlasmaLab/EkoPlasma - The Future of Complex Plasma Research in Space

    NASA Astrophysics Data System (ADS)

    Knapek, Christina; Fortov, Vladimir; Huber, Peter; Mohr, Daniel; Konopka, Uwe; Lipaev, Andrey; Molotkov, Vladimir; Petrov, Oleg; Zähringer, Erich; Thomas, Hubertus

    2016-07-01

    The PlasmaLab project, a Russian-German cooperation, has the aim to develop a future laboratory for the investigation of complex plasmas under microgravity conditions on the International Space Station (ISS). Within the project, a new plasma chamber, the Zyflex chamber, has been developed and is now being prepared to be launched to the ISS in 2020 as a laboratory setup with the name EkoPlasma (Experiment komplex Plasma). The Zyflex chamber is a large, cylindrical plasma chamber with parallel, rf-driven electrodes and a flexible inner geometry. It is designed to extend the accessible experimental parameter range and to allow an independent control of the plasma parameters, therefore increasing the experimental possibilities and expected knowledge gain significantly. Further, a 3D optical diagnostic will allow for the study of particle dynamics in 3D realtime. Possible future research topics include e.g. phase transitions, the dynamics of liquids, phase separation, or turbulence. The experimental setup will be presented, as well as some preliminary results of experiments on earth and in parabolic flights to visualize the possibilities of this new laboratory. This work and some of the authors are funded by DLR/BMWi (FKZ 50WM1441).

  11. Systems biology in psychiatric research: from complex data sets over wiring diagrams to computer simulations.

    PubMed

    Tretter, Felix; Gebicke-Haerter, Peter J

    2012-01-01

    The classification of psychiatric disorders has always been a problem in clinical settings. The present debate about the major systems in clinical practice, DSM-IV and ICD-10, has resulted in attempts to improve and replace those schemes by some that include more endophenotypic and molecular features. However, these disorders not only require more precise diagnostic tools, but also have to be viewed more extensively in their dynamic behaviors, which require more precise data sets related to their origins and developments. This enormous challenge in brain research has to be approached on different levels of the biological system by new methods, including improvements in electroencephalography, brain imaging, and molecular biology. All these methods entail accumulations of large data sets that become more and more difficult to interpret. In particular, on the molecular level, there is an apparent need to use highly sophisticated computer programs to tackle these problems. Evidently, only interdisciplinary work among mathematicians, physicists, biologists, and clinicians can further improve our understanding of complex diseases of the brain.

  12. The Results of Complex Research of GSS "SBIRS-Geo 2" Behavior in the Orbit

    NASA Astrophysics Data System (ADS)

    Sukhov, P. P.; Epishev, V. P.; Sukhov, K. P.; Karpenko, G. F.; Motrunich, I. I.

    2017-04-01

    The new generation of geosynchronous satellites SBIRS of US Air Force early warning system series (Satellite Early Warning System) replaced the previous DSP-satellite series (Defense Support Program). Currently from the territory of Ukraine, several GSS of DSP series and one "SBIRS-Geo 2" are available to observation. During two years of observations, we have received and analyzed for two satellites more than 30 light curves in B, V, R photometric system. As a result of complex research, we propose a model of "SBIRS-Geo" 2 orbital behavior compared with the same one of the DSP-satellite. To control the entire surface of the Earth with 15-16 sec interval, including the polar regions, 4 SBIRS satellites located every 90 deg. along the equator are enough in GEO orbit. Since DSP-satellites provide the coverage of the Earth's surface to 83 deg. latitudes with a period of 50 sec, DSP-satellites should be 8. All the conclusions were made based on an analysis of photometric and coordinate observations using the simulation of the dynamics of their orbital behavior.

  13. Research on infrared dim-point target detection and tracking under sea-sky-line complex background

    NASA Astrophysics Data System (ADS)

    Dong, Yu-xing; Li, Yan; Zhang, Hai-bo

    2011-08-01

    Target detection and tracking technology in infrared image is an important part of modern military defense system. Infrared dim-point targets detection and recognition under complex background is a difficulty and important strategic value and challenging research topic. The main objects that carrier-borne infrared vigilance system detected are sea-skimming aircrafts and missiles. Due to the characteristics of wide field of view of vigilance system, the target is usually under the sea clutter. Detection and recognition of the target will be taken great difficulties .There are some traditional point target detection algorithms, such as adaptive background prediction detecting method. When background has dispersion-decreasing structure, the traditional target detection algorithms would be more useful. But when the background has large gray gradient, such as sea-sky-line, sea waves etc .The bigger false-alarm rate will be taken in these local area .It could not obtain satisfactory results. Because dim-point target itself does not have obvious geometry or texture feature ,in our opinion , from the perspective of mathematics, the detection of dim-point targets in image is about singular function analysis .And from the perspective image processing analysis , the judgment of isolated singularity in the image is key problem. The foregoing points for dim-point targets detection, its essence is a separation of target and background of different singularity characteristics .The image from infrared sensor usually accompanied by different kinds of noise. These external noises could be caused by the complicated background or from the sensor itself. The noise might affect target detection and tracking. Therefore, the purpose of the image preprocessing is to reduce the effects from noise, also to raise the SNR of image, and to increase the contrast of target and background. According to the low sea-skimming infrared flying small target characteristics , the median filter is used to

  14. Research on the optimal selection method of image complexity assessment model index parameter

    NASA Astrophysics Data System (ADS)

    Zhu, Yong; Duan, Jin; Qian, Xiaofei; Xiao, Bo

    2015-10-01

    Target recognition is widely used in national economy, space technology and national defense and other fields. There is great difference between the difficulty of the target recognition and target extraction. The image complexity is evaluating the difficulty level of extracting the target from background. It can be used as a prior evaluation index of the target recognition algorithm's effectiveness. The paper, from the perspective of the target and background characteristics measurement, describe image complexity metrics parameters using quantitative, accurate mathematical relationship. For the collinear problems between each measurement parameters, image complexity metrics parameters are clustered with gray correlation method. It can realize the metrics parameters of extraction and selection, improve the reliability and validity of image complexity description and representation, and optimize the image the complexity assessment calculation model. Experiment results demonstrate that when gray system theory is applied to the image complexity analysis, target characteristics image complexity can be measured more accurately and effectively.

  15. A model for integrating clinical care and basic science research, and pitfalls of performing complex research projects for addressing a clinical challenge.

    PubMed

    Steck, R; Epari, D R; Schuetz, M A

    2010-07-01

    The collaboration of clinicians with basic science researchers is crucial for addressing clinically relevant research questions. In order to initiate such mutually beneficial relationships, we propose a model where early career clinicians spend a designated time embedded in established basic science research groups, in order to pursue a postgraduate qualification. During this time, clinicians become integral members of the research team, fostering long term relationships and opening up opportunities for continuing collaboration. However, for these collaborations to be successful there are pitfalls to be avoided. Limited time and funding can lead to attempts to answer clinical challenges with highly complex research projects characterised by a large number of "clinical" factors being introduced in the hope that the research outcomes will be more clinically relevant. As a result, the complexity of such studies and variability of its outcomes may lead to difficulties in drawing scientifically justified and clinically useful conclusions. Consequently, we stress that it is the basic science researcher and the clinician's obligation to be mindful of the limitations and challenges of such multi-factorial research projects. A systematic step-by-step approach to address clinical research questions with limited, but highly targeted and well defined research projects provides the solid foundation which may lead to the development of a longer term research program for addressing more challenging clinical problems. Ultimately, we believe that it is such models, encouraging the vital collaboration between clinicians and researchers for the work on targeted, well defined research projects, which will result in answers to the important clinical challenges of today. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  16. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-12-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment.

  17. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed Central

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-01-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment. PMID:12634133

  18. The center for plant and microbial complex carbohydrates at the University of Georgia Complex Carbohydrate Research Center. Five-year report, September 15, 1987--December 31, 1992

    SciTech Connect

    Albersheim, Peter; Darvill, Alan

    1992-05-01

    The Complex Carbohydrate Research Center (CCRC) is the home of ten independent but complementary interdisciplinary research groups led by nine regular faculty and one adjunct faculty. The research of these groups represents a broad spectrum of interests, and they are involved in about 90 collaborations with their CCRC and UGA colleagues and with scientists at other institutions and companies in the US, Canada, Europe, Israel, and Japan. The hallmark of the CCRC is the collaborative, interactive environment encouraged by its directors, faculty and tong-term staff. Newcomers to the CCRC or short-term members soon learn that everyone benefits from this process. The team-oriented approach in carbohydrate science translates into the day-today generous giving of one's time and expertise to the work of others, whether it be in sharing specialized instrumentation, participating in the design of experiments and interpretalon of data, providing service to scientists outside the CCRC, or joining collaborative projects. The CCRC is founded on the principle that the cross-fertilization of ideas and know-how leads to the synergistic advancement of science. This report contains a series of appendices that document the extent and breadth of the Plant and Microbial Carbohydrate Center's contributions to collaborative research and education. Several collaborative research projects that have received postdoctoral research associate support from the Grant are highlighted, as these projects are particularly illustrative of the wide-ranging collaborations that have evolved as a result of this Grant and the quality of the science that the Grant enables.

  19. Modeling, Simulation and Analysis of Complex Networked Systems: A Program Plan for DOE Office of Advanced Scientific Computing Research

    SciTech Connect

    Brown, D L

    2009-05-01

    Many complex systems of importance to the U.S. Department of Energy consist of networks of discrete components. Examples are cyber networks, such as the internet and local area networks over which nearly all DOE scientific, technical and administrative data must travel, the electric power grid, social networks whose behavior can drive energy demand, and biological networks such as genetic regulatory networks and metabolic networks. In spite of the importance of these complex networked systems to all aspects of DOE's operations, the scientific basis for understanding these systems lags seriously behind the strong foundations that exist for the 'physically-based' systems usually associated with DOE research programs that focus on such areas as climate modeling, fusion energy, high-energy and nuclear physics, nano-science, combustion, and astrophysics. DOE has a clear opportunity to develop a similarly strong scientific basis for understanding the structure and dynamics of networked systems by supporting a strong basic research program in this area. Such knowledge will provide a broad basis for, e.g., understanding and quantifying the efficacy of new security approaches for computer networks, improving the design of computer or communication networks to be more robust against failures or attacks, detecting potential catastrophic failure on the power grid and preventing or mitigating its effects, understanding how populations will respond to the availability of new energy sources or changes in energy policy, and detecting subtle vulnerabilities in large software systems to intentional attack. This white paper outlines plans for an aggressive new research program designed to accelerate the advancement of the scientific basis for complex networked systems of importance to the DOE. It will focus principally on four research areas: (1) understanding network structure, (2) understanding network dynamics, (3) predictive modeling and simulation for complex networked systems

  20. Experience in Remote Demolition of the Activated Biological Shielding of the Multi Purpose Research Reactor (MZFR) on the German Karlsruhe Site - 12208

    SciTech Connect

    Eisenmann, Beata; Fleisch, Joachim; Prechtl, Erwin; Suessdorf, Werner; Urban, Manfred

    2012-07-01

    In 2009, WAK Decommissioning and Waste Management GmbH (WAK) became owner and operator of the waste treatment facilities of Karlsruhe Institute of Technology (KIT) as well as of the prototype reactors, the Compact Sodium-Cooled Fast Reactor (KNK) and Multi-Purpose Reactor (MZFR), both being in an advanced stage of dismantling. Together with the dismantling and decontamination activities of the former WAK reprocessing facility since 1990, the envisaged demolishing of the R and D reactor FR2 and a hot cell facility, all governmentally funded nuclear decommissioning projects on the Karlsruhe site are concentrated under the WAK management. The small space typical of prototype research reactors represented a challenge also during the last phase of activated dismantling, dismantling of the activated biological shield of the MZFR. Successful demolition of the biological shield required detailed planning and extensive testing in the years before. In view of the limited space and the ambient dose rate that was too high for manual work, it was required to find a tool carrier system to take up and control various demolition and dismantling tools in a remote manner. The strategy formulated in the concept of dismantling the biological shield by means of a modified electro-hydraulic demolition excavator in an adaptable working scaffolding turned out to be feasible. The following boundary conditions were essential: - Remote exchange of the dismantling and removal tools in smallest space. - Positioning of various supply facilities on the working platform. - Avoiding of interfering edges. - Optimization of mass flow (removal of the dismantled mass from the working area). - Maintenance in the surroundings of the dismantling area (in the controlled area). - Testing and qualification of the facilities and training of the staff. Both the dismantling technique chosen and the proceeding selected proved to be successful. Using various designs of universal cutters developed on the basis of

  1. Development of a complex type of pour point-viscosity depressant and infrared spectrum research

    SciTech Connect

    Zhang Fusheng; Wang Biao

    1995-11-01

    EMS, a complex type of pour point-viscosity depressant for crudes, is composed of EVA, MVA [molecular structure shown for both in the paper] and Surfactant. After adding EMS into the crudes, a very nice result in reducing pour point and viscosity for Daqing, Jianghan and Jidong crudes was obtained. From the research result of infrared spectroscopy of the interactions between EMS or its components and wax or mixture of resin and asphaltene isolated from three crudes, it has been shown that the area ratio of the double absorption peaks of 719 cm{sup {minus}1} and 729 cm{sup {minus}1} or 1,368 cm{sup {minus}1} and 1,378 cm{sup {minus}1} changed remarkably after EMS or its components were added into wax. It can be inferred that the cocrystallization probably happened between the EMS or its components and the wax. The position of the 4,000--3,000 cm{sup {minus}1} infrared absorption peak of the mixture of resin and asphaltene moved to the lower wavenumber, and the ratio of the area of 1,373 cm{sup {minus}1} absorption peak (methyl) to the combination area of 748, 810 and 871 cm{sup {minus}1} absorption peak (aromatics) increased remarkably. It can be inferred that the pour point-viscosity depressant molecules destroyed the original hydrogen bonds and overlapping of the aromatic ring planes among resin and asphaltene molecules to form a new cubic molecular structure and new hydrogen bonds with the results the viscosity of crude oil will be reduced.

  2. Enriching gender in physics education research: A binary past and a complex future

    NASA Astrophysics Data System (ADS)

    Traxler, Adrienne L.; Cid, Ximena C.; Blue, Jennifer; Barthelemy, Ramón

    2016-12-01

    [This paper is part of the Focused Collection on Gender in Physics.] In this article, we draw on previous reports from physics, science education, and women's studies to propose a more nuanced treatment of gender in physics education research (PER). A growing body of PER examines gender differences in participation, performance, and attitudes toward physics. We have three critiques of this work: (i) it does not question whether the achievements of men are the most appropriate standard, (ii) individual experiences and student identities are undervalued, and (iii) the binary model of gender is not questioned. Driven by these critiques, we propose a conception of gender that is more up to date with other fields and discuss gender as performance as an extended example. We also discuss work on the intersection of identities [e.g., gender with race and ethnicity, socioeconomic status, lesbian, gay, bisexual, and transgender (LGBT) status], much of which has been conducted outside of physics. Within PER, some studies examine the intersection of gender and race, and identify the lack of a single identity as a key challenge of "belonging" in physics. Acknowledging this complexity enables us to further critique what we term a binary gender deficit model. This framework, which is implicit in much of the gender-based PER, casts gender as a fixed binary trait and suggests that women are deficient in characteristics necessary to succeed. Alternative models of gender allow a greater range and fluidity of gender identities, and highlight deficiencies in data that exclude women's experiences. We suggest new investigations that diverge from this expanded gender framework in PER.

  3. Listen to me, too! Lessons from involving children with complex healthcare needs in research about multi-agency services.

    PubMed

    Watson, D; Abbott, D; Townsley, R

    2007-01-01

    Children with complex healthcare needs are often excluded, both from active involvement in research projects and from direct consultation in services. During a 3-year research study into multi-agency services for children with complex healthcare needs, the authors involved children in a number of innovative ways and endeavoured to discover what impact, if any, multi-agency working made to them. The researchers 'spent time' with 18 children with complex healthcare needs. They used a variety of methods to engage with the children in a meaningful way. More than half of the children had no verbal communication, so it was necessary in some cases to work with an advocate, usually the parent, to aid the process. Children with complex healthcare needs can take part in research as long as the research is set up sensitively and flexibly. In terms of the impact of multi-agency working, the authors concluded significant advances had been achieved for this group: almost all the children were living at home and attending school. However, there were significant gaps in addressing children's human rights in relation to communication, independence and relationships. In addition, many of the children had very little effective direct consultation with the multi-agency services. There are significant advances in involving disabled children in research and in service delivery, but there is still some way to go in involving those with complex healthcare needs. The challenges are considerable, but the benefits far outweigh these, not least being the value that parents, carers and the children themselves place upon being listened to.

  4. General Purpose Ground Forces: What Purpose?

    DTIC Science & Technology

    1993-04-06

    RCH~V~AL COPY NATIONAL WAR COLLEGE "GENERAL PURPOSE GROUND FORCES" WHAT PURPOSE ?" LTC DAN CHALLIS 6 APRIL 1993 N A T I O N A L...06-04-1993 to 06-04-1993 4. TITLE AND SUBTITLE General Purpose Ground Forces: What Purpose ? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...The ~Jarm glow of a much heralded Cold War victory, plus the Gulf War t:ciumph, the growth of democracy in developing countries, and the apparent

  5. Affordances and Constraints in the Context of Teacher Collaboration for the Purpose of Data Use

    ERIC Educational Resources Information Center

    Datnow, Amanda; Park, Vicki; Kennedy-Lewis, Brianna

    2013-01-01

    Purpose: An increasing number of schools and districts across the US are requiring teachers to collaborate for the purpose of data-driven decision making. Research suggests that both data use and teacher collaboration are important ingredients in the school improvement process. Existing studies also reveal the complexities of teacher collaboration…

  6. A Comparative Study of the Variables Used to Measure Syntactic Complexity and Accuracy in Task-Based Research

    ERIC Educational Resources Information Center

    Inoue, Chihiro

    2016-01-01

    The constructs of complexity, accuracy and fluency (CAF) have been used extensively to investigate learner performance on second language tasks. However, a serious concern is that the variables used to measure these constructs are sometimes used conventionally without any empirical justification. It is crucial for researchers to understand how…

  7. A Comparative Study of the Variables Used to Measure Syntactic Complexity and Accuracy in Task-Based Research

    ERIC Educational Resources Information Center

    Inoue, Chihiro

    2016-01-01

    The constructs of complexity, accuracy and fluency (CAF) have been used extensively to investigate learner performance on second language tasks. However, a serious concern is that the variables used to measure these constructs are sometimes used conventionally without any empirical justification. It is crucial for researchers to understand how…

  8. COORDINATING, COMMUNICATING AND PERFORMING COMPLEX RESEARCH THAT IDENTIFIES VULNERABLE STREAM ECOSYSTEM IN THE MID-ATLANTIC REGION

    EPA Science Inventory

    The USEPA's Regional Vulnerability Assessment (ReVA) program was created to advance the scientific basis for protecting vulnerable ecosystems at a regional scale. As a first step, the ReVa program will coordinate, communicate and perform complex research that will identify vulner...

  9. Use of the Medical Research Council Framework to Develop a Complex Intervention in Pediatric Occupational Therapy: Assessing Feasibility

    ERIC Educational Resources Information Center

    Missiuna, Cheryl; Pollock, Nancy; Campbell, Wenonah N.; Bennett, Sheila; Hecimovich, Catherine; Gaines, Robin; DeCola, Cindy; Cairney, John; Russell, Dianne; Molinaro, Elizabeth

    2012-01-01

    The United Kingdom Medical Research Council recommends use of a conceptual framework for designing and testing complex therapeutic interventions. "Partnering for Change" (P4C) is an innovative school-based intervention for children with Developmental Coordination Disorder (DCD) that was developed by an interdisciplinary team who were…

  10. Reactions to "Ethical Challenges and Complexities of Including People with Intellectual Disability as Participants in Research" by Dr Teresa Iacono

    ERIC Educational Resources Information Center

    Aman, Michael G.; Handen, Benjamin

    2006-01-01

    The authors' reaction to Dr Teresa Iacono's article "Ethical challenges and complexities of including people with intellectual disability as participants in research" is presented. Among other things, they find that Dr Iacono has done an outstanding job of describing creative solutions for obtaining appropriate informed consent from people with…

  11. Use of the Medical Research Council Framework to Develop a Complex Intervention in Pediatric Occupational Therapy: Assessing Feasibility

    ERIC Educational Resources Information Center

    Missiuna, Cheryl; Pollock, Nancy; Campbell, Wenonah N.; Bennett, Sheila; Hecimovich, Catherine; Gaines, Robin; DeCola, Cindy; Cairney, John; Russell, Dianne; Molinaro, Elizabeth

    2012-01-01

    The United Kingdom Medical Research Council recommends use of a conceptual framework for designing and testing complex therapeutic interventions. "Partnering for Change" (P4C) is an innovative school-based intervention for children with Developmental Coordination Disorder (DCD) that was developed by an interdisciplinary team who were…

  12. Reactions to "Ethical Challenges and Complexities of Including People with Intellectual Disability as Participants in Research" by Dr Teresa Iacono

    ERIC Educational Resources Information Center

    Aman, Michael G.; Handen, Benjamin

    2006-01-01

    The authors' reaction to Dr Teresa Iacono's article "Ethical challenges and complexities of including people with intellectual disability as participants in research" is presented. Among other things, they find that Dr Iacono has done an outstanding job of describing creative solutions for obtaining appropriate informed consent from people with…

  13. Protocol for the process evaluation of a complex intervention designed to increase the use of research in health policy and program organisations (the SPIRIT study).

    PubMed

    Haynes, Abby; Brennan, Sue; Carter, Stacy; O'Connor, Denise; Schneider, Carmen Huckel; Turner, Tari; Gallego, Gisselle

    2014-09-27

    Process evaluation is vital for understanding how interventions function in different settings, including if and why they have different effects or do not work at all. This is particularly important in trials of complex interventions in 'real world' organisational settings where causality is difficult to determine. Complexity presents challenges for process evaluation, and process evaluations that tackle complexity are rarely reported. This paper presents the detailed protocol for a process evaluation embedded in a randomised trial of a complex intervention known as SPIRIT (Supporting Policy In health with Research: an Intervention Trial). SPIRIT aims to build capacity for using research in health policy and program agencies. We describe the flexible and pragmatic methods used for capturing, managing and analysing data across three domains: (a) the intervention as it was implemented; (b) how people participated in and responded to the intervention; and (c) the contextual characteristics that mediated this relationship and may influence outcomes. Qualitative and quantitative data collection methods include purposively sampled semi-structured interviews at two time points, direct observation and coding of intervention activities, and participant feedback forms. We provide examples of the data collection and data management tools developed. This protocol provides a worked example of how to embed process evaluation in the design and evaluation of a complex intervention trial. It tackles complexity in the intervention and its implementation settings. To our knowledge, it is the only detailed example of the methods for a process evaluation of an intervention conducted as part of a randomised trial in policy organisations. We identify strengths and weaknesses, and discuss how the methods are functioning during early implementation. Using 'insider' consultation to develop methods is enabling us to optimise data collection while minimising discomfort and burden for

  14. Because Trucks Aren't Bicycles: Orthographic Complexity as an Important Variable in Reading Research

    ERIC Educational Resources Information Center

    Galletly, Susan A.; Knight, Bruce Allen

    2013-01-01

    Severe enduring reading- and writing-accuracy difficulties seem a phenomenon largely restricted to nations using complex orthographies, notably Anglophone nations, given English's highly complex orthography (Geva and Siegel, "Read Writ" 12:1-30, 2000; Landerl et al., "Cognition" 63:315-334, 1997; Share, "Psychol Bul"l…

  15. Using Multiple Sources of Information in Establishing Text Complexity. Reading Research Report. #11.03

    ERIC Educational Resources Information Center

    Hiebert, Elfrieda H.

    2011-01-01

    A focus of the Common Core State Standards/English Language Arts (CCSS/ELA) is that students become increasingly more capable with complex text over their school careers. This focus has redirected attention to the measurement of text complexity. Although CCSS/ELA suggests multiple criteria for this task, the standards offer a single measure of…

  16. Enthused research on DNA-binding and DNA-cleavage aptitude of mixed ligand metal complexes

    NASA Astrophysics Data System (ADS)

    Mahalakshmi, Rajkumar; Raman, Natarajan

    2013-08-01

    Five new Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) mixed ligand complexes have been synthesized using a Schiff base precursor (obtained by the condensation of N-(4-aminophenyl)acetamide and 4-chlorobenzaldehyde) as main ligand and 1,10-phenanthroline as co-ligand. They have been characterized by microanalytical data, IR, UV-Vis, magnetic moment values, conductivity and electrochemical measurements. The spectral data reveal that all the complexes exhibit octahedral geometry. The high electrical conductance of the complexes supports their electrolytic nature. The monomeric nature of the complexes has been assessed from their magnetic susceptibility values. These complexes are better antimicrobial active agents than the free ligands. DNA (CT) binding properties of these complexes have been explored by UV-Vis., viscosity measurements, cyclic voltammetry, and differential pulse voltammetry measurements. The oxidative cleavage activity of the complexes has been studied using supercoiled pUC19 DNA by gel electrophoresis. The experimental results show that the complexes are good intercalators.

  17. Because Trucks Aren't Bicycles: Orthographic Complexity as an Important Variable in Reading Research

    ERIC Educational Resources Information Center

    Galletly, Susan A.; Knight, Bruce Allen

    2013-01-01

    Severe enduring reading- and writing-accuracy difficulties seem a phenomenon largely restricted to nations using complex orthographies, notably Anglophone nations, given English's highly complex orthography (Geva and Siegel, "Read Writ" 12:1-30, 2000; Landerl et al., "Cognition" 63:315-334, 1997; Share, "Psychol Bul"l…

  18. Enthused research on DNA-binding and DNA-cleavage aptitude of mixed ligand metal complexes.

    PubMed

    Mahalakshmi, Rajkumar; Raman, Natarajan

    2013-08-01

    Five new Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) mixed ligand complexes have been synthesized using a Schiff base precursor (obtained by the condensation of N-(4-aminophenyl)acetamide and 4-chlorobenzaldehyde) as main ligand and 1,10-phenanthroline as co-ligand. They have been characterized by microanalytical data, IR, UV-Vis, magnetic moment values, conductivity and electrochemical measurements. The spectral data reveal that all the complexes exhibit octahedral geometry. The high electrical conductance of the complexes supports their electrolytic nature. The monomeric nature of the complexes has been assessed from their magnetic susceptibility values. These complexes are better antimicrobial active agents than the free ligands. DNA (CT) binding properties of these complexes have been explored by UV-Vis., viscosity measurements, cyclic voltammetry, and differential pulse voltammetry measurements. The oxidative cleavage activity of the complexes has been studied using supercoiled pUC19 DNA by gel electrophoresis. The experimental results show that the complexes are good intercalators.

  19. Working with lay people in health service research: a model of co-evolution based on complexity theory.

    PubMed

    Kernick, David; Mitchell, Annie

    2010-01-01

    Involving lay researchers is an important part of Government policy in the United Kingdom within the context of the National Health Service. Here we draw upon insights from complexity theory to suggest a model that we call consensual qualitative research where lay researchers and professionals are co-producers of knowledge. The focus of attention is on understanding and facilitating the patterns that emerge from non-linear interaction at a local level. We describe some core principles that can facilitate the development of such a model and conclude that the resources in terms of time and effort that such an approach requires, should not be underestimated.

  20. Experiences and challenges in implementing complex community-based research project: the Pacific Obesity Prevention in Communities project.

    PubMed

    Schultz, J T; Moodie, M; Mavoa, H; Utter, J; Snowdon, W; McCabe, M P; Millar, L; Kremer, P; Swinburn, B A

    2011-11-01

    Policy makers throughout the world are struggling to find effective ways to prevent the rising trend of obesity globally, particularly among children. The Pacific Obesity Prevention in Communities project was the first large-scale, intervention research project conducted in the Pacific aiming to prevent obesity in adolescents. The project spanned four countries: Australia, New Zealand, Fiji and Tonga. This paper reports on the strengths and challenges experienced from this complex study implemented from 2004 to 2009 across eight cultural groups in different community settings. The key strengths of the project were its holistic collaborative approach, participatory processes and capacity building. The challenges inherent in such a large complex project were underestimated during the project's development. These related to the scale, complexity, duration, low research capacity in some sites and overall coordination across four different countries. Our experiences included the need for a longer lead-in time prior to intervention for training and up-skilling of staff in Fiji and Tonga, investment in overall coordination, data quality management across all sites and the need for realistic capacity building requirements for research staff. The enhanced research capacity and skills across all sites include the development and strengthening of research centres, knowledge translation and new obesity prevention projects.