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Sample records for q devices

  1. Air-Q intubating laryngeal airway: A study of the second generation supraglottic airway device

    PubMed Central

    Attarde, Viren Bhaskar; Kotekar, Nalini; Shetty, Sarika M

    2016-01-01

    Background and Aims: Air-Q intubating laryngeal mask airway (ILA) is used as a supraglottic airway device and as a conduit for endotracheal intubation. This study aims to assess the efficacy of the Air-Q ILA regarding ease of insertion, adequacy of ventilation, rate of successful intubation, haemodynamic response and airway morbidity. Methods: Sixty patients presenting for elective surgery at our Medical College Hospital were selected. Following adequate premedication, baseline vital parameters, pulse rate and blood pressure were recorded. Air-Q size 3.5 for patients 50-70 kg and size 4.5 for 70-100 kg was selected. After achieving adequate intubating conditions, Air-Q ILA was introduced. Confirming adequate ventilation, appropriate sized endotracheal tube was advanced through the Air-Q blindly to intubate the trachea. Placement of the endotracheal tube in trachea was confirmed. Results: Air-Q ILA was successfully inserted in 88.3% of patients in first attempt and 11.7% patients in second attempt. Ventilation was adequate in 100% of patients. Intubation was successful in 76.7% of patients with Air-Q ILA. 23.3% of patients were intubated by direct laryngoscopy following failure with two attempts using Air-Q ILA. Post-intubation the change in heart rate was statistically significant (P < 0.0001). 10% of patients were noted to have a sore throat and 5% of patients had mild airway trauma. Conclusion: Air-Q ILA is a reliable device as a supraglottic airway ensuring adequate ventilation as well as a conduit for endotracheal intubation. It benefits the patient by avoiding the stress of direct laryngoscopy and is also superior alternative device for use in a difficult airway. PMID:27212722

  2. Measurement-device-independent quantum key distribution with q-plate

    NASA Astrophysics Data System (ADS)

    Chen, Dong; Shang-Hong, Zhao; Ying, Sun

    2015-12-01

    The original measurement-device-independent quantum key distribution is reviewed and a modified protocol using rotation invariant photonic state is proposed. A hybrid encoding approach combined polarization qubit with orbit angular momentum qubit is adopted to overcome the polarization misalignment associated with random rotations in long-distance quantum key distribution. The initial encoding and final decoding of information in our MDI-QKD implementation protocol can be conveniently performed in the polarization space, while the transmission is done in the rotation invariant hybrid space. Our analysis indicates that both the secure key rate and transmission distance can be improved with our modified protocol owing to the lower quantum bit error rate. Furthermore, our hybrid encoding approach only needs to insert four q-plates in practical experiment and to overcome the polarization misalignment problem mentioned above without including any feedback control.

  3. Parallel generation of multiple first-order vector beams with a polarization grating and a q-plate device

    NASA Astrophysics Data System (ADS)

    Badham, Katherine; Moreno, Ignacio; Sánchez-López, María M.; Davis, Jeffrey A.; Hashimoto, Nobuyuki; Kurihara, Makoto; Albero, Jorge; Cottrell, Don M.

    2016-12-01

    Vector beams, usually generated using q-plates, are of interest because their polarization state varies spatially. In general, the q-plate performance is examined by illuminating the device and detecting the output beam with polarization states on the 6 cardinal points on the zero-order Poincaré sphere, requiring a total of 36 separate measurements. In this work we present a powerful technique to generate arbitrary vector beams in parallel, thus reducing the number of measurements required. We begin with a programmable polarization diffraction grating capable to generate an arbitrary number of diffraction orders with defined polarization states selected at will. Then we combine this grating with a segmented q-plate device with q = 1/2 value. Using this combination, the parallel generation of six arbitrary first-order vector beams is achieved in a single shot. Therefore, the analysis of these beams can be greatly reduced.

  4. Description and evaluation of the Res-Q Arrhythmia Control Device.

    PubMed

    Miller, R E; Wilkoff, B L

    1995-02-01

    The Res-Q Arrhythmia Control Device (Intermedics Inc.) is one of the latest entries into the growing implantable cardioverter defibrillator (ICD) market. Dysrhythmias are classified according to their zone of detection, with a bradycardia zone, up to 3 tachycardia zones, and a fibrillation zone. Detection criterion, therapies, and redetection criterion within each zone are independently programmable, tailoring the setup to each individual's needs. In a hierarchical manner, this allows efficacy, urgency, and patient comfort to be appropriately balanced. Tachycardia therapy options include antitachycardia pacing (ATP), low-energy cardioversion, and high-energy shock, while VVI pacing provides bradycardia therapy. ATP programming is extremely flexible. Biphasic waveform and a maximum output of 700 V have yielded a high rate of successful implantation. Unique features include the multiprogrammable sensing autogain, which tracks evoked T waves during pacing, as well as the use of the pulse generator to perform implant testing. Major strengths include programming flexibility and individualized therapy for multiple dysrhythmias. The major shortcoming relates to a lack of stored electrograms. Although long-term follow-up is not yet available, the Res-Q appears to be a capable challenger to a peer group of advanced generation ICDs.

  5. Processing of Diamond for Integrated Optic Devices Using Q-Switched Nd:YAG Laser at Different Wavelengths

    NASA Astrophysics Data System (ADS)

    Sudheer, S. K.; Pillai, V. P. Mahadevan; Nayar, V. U.

    In the present investigation, a Q-switched Nd:YAG laser is used to study the various aspects of diamond processing for fabricating integrated optic and UV optoelectronic devices. Diamond is a better choice of substrate compared to silicon and gallium arsenide for the fabrication of waveguides to perform operations such as modulation, switching, multiplexing, and filtering, particularly in the ultraviolet spectrum. The experimental setup of the present investigation consists of two Q-Switched Nd:YAG lasers capable of operating at wavelengths of 1064 nm and 532 nm. The diamond cutting is performed using these two wavelengths by making the "V"-shaped groove with various opening angle. The variation of material loss of diamond during cutting is noted for the two wavelengths. The cut surface morphology and elemental and structural analysis of graphite formed during processing in both cases are compared using scanning electron microscopy (SEM) and laser Raman spectroscopy. Both the Q-Switched Nd:YAG laser systems (at 1064 nm and 532 nm) show very good performance in terms of peak-to-peak output stability, minimal spot diameter, smaller divergence angle, higher peak power in Q-switched mode, and good fundamental TEM00 mode quality for processing natural diamond stones. Less material loss and minimal micro cracks are achieved with wavelength 532 nm whereas a better diamond cut surface is achieved with processing at 1064 nm with minimum roughness.

  6. Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.

    PubMed

    Vollmer, Frank; Yang, Lan

    2012-12-01

    Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences.

  7. Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

    PubMed Central

    Yang, Lan

    2015-01-01

    Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences. PMID:26918228

  8. Ag-nanoparticle as a Q switched device for tunable C-band fiber laser

    NASA Astrophysics Data System (ADS)

    Ahmad, H.; Ruslan, N. E.; Ali, Z. A.; Reduan, S. A.; Lee, C. S. J.; Shaharuddin, R. A.; Nayan, N.; Ismail, M. A.

    2016-12-01

    The use of silver (Ag)-nanoparticle as saturable absorber (SA) to induce tunable Q-switched fiber laser in C-band is demonstrated. The Ag-nanoparticle SA exhibits modulation depth of 31.6% and saturation intensity of 0.54 MW cm-2. The SA is integrated into the laser cavity by sandwiching it between two fiber ferrules. Lasing in CW region starts at 10 mW, whereas stable self-starting Q-switching with a central wavelength of 1558.4 nm begins at 20 mW. As the pump power increases, the repetition rate varies from 10.5 kHz to 24.4 kHz and the narrowest pulse width obtained is around 6.5 μs. The Q-switched laser has a tuning range of 27.3 nm (1552.9-1580.2 nm). The stability of the pulse is verified from the radio-freqeuncy (RF) spectrum with a measured signal-to-noise ratio (SNR) of 46.22 dB. The ability of Ag-nanoparticle as an effective SA may lead to further development of pulsed fiber laser in the field of photonics.

  9. NIMROD Simulations of Low-q Disruptions in the Compact Toroidal Hybrid Device (CTH)

    NASA Astrophysics Data System (ADS)

    Howell, E. C.; Pandya, M. D.; Hanson, J. D.; Mauer, D. A.; Ennis, D. A.; Hartwell, G. J.

    2016-10-01

    Nonlinear MHD simulations of low-q disruptions in the CTH are presented. CTH is a current carrying stellarator that is used to study the effects of 3D shaping. The application of 3D shaping stabilizes low-q disruptions in CTH. The amount of 3D shaping is controlled by adjusting the external rotational transform, and it is characterized by the ratio of the external rotational transform to the total transform: f =ιvac / ι . Disruptions are routinely observed during operation with weak shaping (f < 0.05). The frequency of disruptions decreases with increasing amounts of 3D shaping, and the disruptions are completely suppressed for f > 0.1 . Nonlinear simulations are performed using the NIMROD code to better understand how the shaping suppresses the disruptions. Comparisons of runs with weak (f = 0.04) and strong (f = 0.10) shaping are shown. This material is based upon work supported by Auburn University and the U.S. Department of Energy, Office of Science, Office of Fusion Energy Sciences under Award Numbers DE-FG02-03ER54692 and DE-FG02-00ER54610.

  10. Electronic structure of donor-spacer-acceptor molecules of potential interest for molecular electronics. IV. Geometry and device properties of P3CNQ and Q3CNQ

    NASA Astrophysics Data System (ADS)

    Broo, Anders; Zerner, Michael C.

    1995-07-01

    Z-β-(1-hexadecyl-4-quinolinium)-α-cyano-4-styryldicyanomethanide (C 16H 33-Q3CNQ) and the pyridinium analogue Z-β-(1-hexadecyl-4-pyridinium)-α-cyano-4-styryldicyanomethanide (C 16H 33-P3NCQ) are two very promising candidates for molecular device design. We obtain the geometry of the ground and excited state of these systems using the PM3 quantum mechanical model. The absorption spectra in vacuum and in solution are calculated using the INDO/Cl model, and compared to experimental spectra. The solvatochromic shift of the absorption spectra was calculated using a self-consistent reaction field approach. The observed bleaching of Langmuir-Blodgett films and solutions of C 16H 33-Q3CNQ and C 16H 33-P3CNQ is explained as resulting from a twisted configuration formed without barrier upon absorption into a twisted intramolecular charge transfer state. The observed rectification is explained from a ground state potential energy surface with two minima, one of which is characterized by a very large dipole moment. The relative energy of these minima is easily shifted by an electric field. The overall electron transport rate is found to be very small due to the small electronic coupling between the mono-layers of the L-B film. Thus, the electron transport through the sample is likely through defects of the L-B film. A way to increase the electronic coupling between the mono-layers is also discussed.

  11. [Nitrous Oxide Exposure-mediated Increases in Cuff Pressure: A Comparison of Disposable Type and Re-use Type air-Q Devices].

    PubMed

    Miyazaki, Yu; Komasawa, Nobuyasu; Fujiawara, Shunsuke; Majima, Nozomi; Tatsumi, Shinichi; Minami, Toshiaki

    2015-02-01

    BaCKGROUND: The present study aimed to compare nitrous oxide-mediated increases in cuff pressure between the disposable type air-Q (air-Q-DT) and re-use type air-Q (air-Q-RU) in a simulated adult airway model. Automated cuff pressure was adjusted to 10, 20, and 30 cmH2O. The air-Q-DT and air-Q-RU were exposed to 80% nitrous oxide and cuff pressure was measured 15 and 30 minutes later. Cuff pressure of the air-Q-DT was significantly lower than that of the air-Q-RU after 15 and 30 minutes, regardless of the initial pressure. The polyvinyl chloride-based air-Q-DT may be more effective than the silicon-based air-Q-RU in preventing hyperinflation of the tracheal tube cuff in response to nitrous oxide exposure.

  12. DIGITAL Q METER

    DOEpatents

    Briscoe, W.L.

    1962-02-13

    A digital Q meter is described for measuring the Q of mechanical or electrical devices. The meter comprises in combination a transducer coupled to an input amplifier, and an upper and lower level discriminator coupled to the amplifier and having their outputs coupled to an anticoincidence gate. The output of the gate is connected to a scaler. The lower level discriminator is adjusted to a threshold level of 36.8 percent of the operating threshold level of the upper level discriminator. (AEC)

  13. [Q fever].

    PubMed

    Frangoulidis, Dimitrios; Fischer, Silke F

    2015-08-01

    The article summarizes some important recently identified findings about the Coxiella burnetii disease, Q fever. Beside new diagnostic parameters for follow-up issues, the importance of a timely identification of chronic Q fever and the peculiarities of the post Q fever fatigue syndrome are depicted. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    SciTech Connect

    Ulrickson, M.A.; Stevens, P.L.; Hino, T.; Hirohata, Y.

    1996-12-01

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage.

  15. Q Fever

    MedlinePlus

    ... infects some animals, such as goats, sheep and cattle. C. burnetii bacteria are found in the birth ... your physician... Diagnosis and Testing Recommended tests… Treatment Antibiotics to treat Q fever... Prevention Avoid getting infected... ...

  16. Q Fever

    PubMed Central

    Maurin, M.; Raoult, D.

    1999-01-01

    Q fever is a zoonosis with a worldwide distribution with the exception of New Zealand. The disease is caused by Coxiella burnetii, a strictly intracellular, gram-negative bacterium. Many species of mammals, birds, and ticks are reservoirs of C. burnetii in nature. C. burnetii infection is most often latent in animals, with persistent shedding of bacteria into the environment. However, in females intermittent high-level shedding occurs at the time of parturition, with millions of bacteria being released per gram of placenta. Humans are usually infected by contaminated aerosols from domestic animals, particularly after contact with parturient females and their birth products. Although often asymptomatic, Q fever may manifest in humans as an acute disease (mainly as a self-limited febrile illness, pneumonia, or hepatitis) or as a chronic disease (mainly endocarditis), especially in patients with previous valvulopathy and to a lesser extent in immunocompromised hosts and in pregnant women. Specific diagnosis of Q fever remains based upon serology. Immunoglobulin M (IgM) and IgG antiphase II antibodies are detected 2 to 3 weeks after infection with C. burnetii, whereas the presence of IgG antiphase I C. burnetii antibodies at titers of ≥1:800 by microimmunofluorescence is indicative of chronic Q fever. The tetracyclines are still considered the mainstay of antibiotic therapy of acute Q fever, whereas antibiotic combinations administered over prolonged periods are necessary to prevent relapses in Q fever endocarditis patients. Although the protective role of Q fever vaccination with whole-cell extracts has been established, the population which should be primarily vaccinated remains to be clearly identified. Vaccination should probably be considered in the population at high risk for Q fever endocarditis. PMID:10515901

  17. Q fever.

    PubMed Central

    Reimer, L G

    1993-01-01

    Q fever is an acute febrile illness first described in 1935 and now seen in many parts of the world. Human infection follows exposure to animals, especially domestic livestock. Recent outbreaks in metropolitan areas have implicated cats as the carrier of disease to humans. The etiologic agent, Coxiella burnetti, belongs to the family Rickettsiaceae, although it has distinct genetic characteristics and modes of transmission. Most recent attention has been focused on a number of large outbreaks of Q fever associated with medical research involving pregnant sheep. Although most infections are self-limited, some patients require prolonged treatment. Recent vaccines have had encouraging success in the prevention of disease in individuals at high risk of exposure. PMID:8358703

  18. Interstitial deletion (6)q13q15

    SciTech Connect

    Gershoni-Baruch, R.; Mandel, H.; Bar El, H.; Bar-Nizan, N.; Borochowitz, Z.; Dar, Hanna

    1996-04-24

    We report on a 2-year-old child with psychomotor retardation, facial and urogenital anomalies. His chromosome constitution was 46,XY,del(6)(q13q15). This case further contributes to the karyotype-phenotype correlation of proximal deletion 6q syndromes. 18 refs., 3 figs., 1 tab.

  19. Open-flavor charm and bottom s q q ¯ Q ¯ and q q q ¯ Q ¯ tetraquark states

    NASA Astrophysics Data System (ADS)

    Chen, Wei; Chen, Hua-Xing; Liu, Xiang; Steele, T. G.; Zhu, Shi-Lin

    2017-06-01

    We provide comprehensive investigations for the mass spectrum of exotic open-flavor charmed/bottom s q q ¯ c ¯ , q q q ¯ c ¯ , s q q ¯ b ¯ , q q q ¯ b ¯ tetraquark states with various spin-parity assignments JP=0+,1+,2+ and 0- , 1- in the framework of QCD sum rules. In the diquark configuration, we construct the diquark-antidiquark interpolating tetraquark currents using the color-antisymmetric scalar and axial-vector diquark fields. The stable mass sum rules are established in reasonable parameter working ranges, which are used to give reliable mass predictions for these tetraquark states. We obtain the mass spectra for the open-flavor charmed/bottom s q q ¯c ¯, q q q ¯c ¯, s q q ¯b ¯, q q q ¯b ¯ tetraquark states with various spin-parity quantum numbers. In addition, we suggest searching for exotic doubly-charged tetraquarks, such as [s d ][u ¯ c ¯ ]→Ds(*)-π- in future experiments at facilities such as BESIII, BelleII, PANDA, LHCb, and CMS, etc.

  20. Laser system to detonate explosive devices

    NASA Technical Reports Server (NTRS)

    Menichelli, V. J.; Yang, L. C.

    1974-01-01

    Detonating system is not affected by electromagnetic interference. System includes laser source, Q-switch, and optical fiber connected to explosive device. Fiber can be branched out and connected to several devices for simultaneous detonation.

  1. Coenzyme Q10 Therapy

    PubMed Central

    Garrido-Maraver, Juan; Cordero, Mario D.; Oropesa-Ávila, Manuel; Fernández Vega, Alejandro; de la Mata, Mario; Delgado Pavón, Ana; de Miguel, Manuel; Pérez Calero, Carmen; Villanueva Paz, Marina; Cotán, David; Sánchez-Alcázar, José A.

    2014-01-01

    For a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ10. Also, at the inner mitochondrial membrane level, CoQ10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ10 levels as well as different ataxias and encephalomyopathies. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit. PMID:25126052

  2. Coenzyme Q10 (PDQ)

    MedlinePlus

    ... healthy. The body also uses CoQ10 as an antioxidant . An antioxidant is a substance that protects cells from chemicals ... of cancer. By protecting cells against free radicals, antioxidants help protect the body against cancer. CoQ10 is ...

  3. Q Fever in Greenland

    PubMed Central

    Svendsen, Claus Bo; Christensen, Jens Jørgen; Bundgaard, Henning; Vindfeld, Lars; Christiansen, Claus Bohn; Kemp, Michael; Villumsen, Steen

    2010-01-01

    We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection. PMID:20202433

  4. Deletion (2)(q37)

    SciTech Connect

    Stratton, R.F.; Tolworthy, J.A.; Young, R.S.

    1994-06-01

    We report on a 5-month-old girl with widely spaced nipples, redundant nuchal skin, coarctation of the aorta, anal atresia with distal fistula, postnatal growth retardation, hypotonia, and sparse scalp hair. Initial clinical assessment suggested the diagnosis of Ullrich-Turner syndrome. Chromosome analysis showed a 46,XX,del(2)(q37) karyotype in peripheral lymphocytes. We compare her findings to those of other reported patients with terminal deletions of 2q. 8 refs., 2 figs., 1 tab.

  5. Emergence of Q fever

    PubMed Central

    Angelakis, E; Raoult, D

    2011-01-01

    Q fever is a worldwide zoonosis with many acute and chronic manifestations caused by the pathogen Coxiella burnetii. Farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. Persons at greatest risk are those in contact with farm animals and include farmers, abattoir workers, and veterinarians. The organs most commonly affected during Q fever are the heart, the arteries, the bones and the liver. The most common clinical presentation is an influenza-like illness with varying degrees of pneumonia and hepatitis. Although acute disease is usually self-limiting, people do occasionally die from this condition. Endocarditis is the most serious and most frequent clinical presentation of chronic Q fever. Vascular infection is the second most frequent presentation of Q fever. The diagnosis of Q fever is based on a significant increase in serum antibody titers. The treatment is effective and well tolerated, but must be adapted to the acute or chronic pattern with the tetracyclines to be considered the mainstay of antibiotic therapy. For the treatment of Q fever during pregnancy the use of long-term cotrimoxazole therapy is proposed. PMID:23113081

  6. Three-region specific microdissection libraries for the long arm of human chromosome 2, regions q33-q35, q31-q32, and q23-q24

    SciTech Connect

    Yu, J.; Tong, S.; Whittier, A.

    1995-09-01

    Three region-specific libraries have been constructed from the long arm of human chromosome 2, including regions 2q33-35 (2Q2 library), 2q31-32 (2Q3) and 2q23-24 (2Q4). Chromosome microdissection and the MboI linker-adaptor microcloning techniques were used in constructing these libraries. The libraries comprised hundreds of thousands of microclones in each library. Approximately half of the microclones in the library contained unique or low-copy number sequence inserts. The insert sizes ranged between 50 and 800 bp, with a mean of 130-190 bp. Southern blot analysis of individual unique sequence microclones showed that 70-94% of the microclones were derived from the dissected region. 31 unique sequence microclones from the 2Q2 library, 31 from 2Q3, and 30 from 2Q4, were analyzed for insert sizes, the hybridizing genomic HindIII fragment sizes, and cross-hybridization to rodent species. These libraries and the short insert microclones derived from the libraries should be useful for high resolution physical mapping, sequence-ready reagents for large scale genomic sequencing, and positional cloning of disease-related genes assigned to these regions, e.g. the recessive familial amyotrophic lateral sclerosis assigned to 2q33-q35, and a type I diabetes susceptibility gene to 2q31-q33. 17 refs., 5 figs., 2 tabs.

  7. Q Q Q ¯Q ¯ states: Masses, production, and decays

    NASA Astrophysics Data System (ADS)

    Karliner, Marek; Nussinov, Shmuel; Rosner, Jonathan L.

    2017-02-01

    The question of whether there exist bound states of two heavy quarks Q =(c ,b ) and antiquarks Q ¯=(c ¯,b ¯), distinct from a pair of quark-antiquark mesons, has been debated for more than forty years. We estimate masses of Q1Q2Q¯3Q¯4 resonant states XQ1Q2Q¯3Q¯4 and suggest a means of producing and observing them. We concentrate on the c c c ¯c ¯ channel which is most easily produced and the b b b ¯b ¯ channel which has a better chance of being relatively narrow. We obtain M (Xc c c ¯ c ¯)=6,192 ±25 MeV and M (Xb b b ¯b ¯)=18,826 ±25 MeV , for the JP C=0++ states involving charmed and bottom tetraquarks, respectively. An experimental search for these states in the predicted mass range is highly desirable.

  8. Depletion-Mode GaN HEMT Q-Spoil Switches for MRI Coils.

    PubMed

    Lu, Jonathan Y; Grafendorfer, Thomas; Zhang, Tao; Vasanawala, Shreyas; Robb, Fraser; Pauly, John M; Scott, Greig C

    2016-12-01

    Q-spoiling is the process of decoupling an MRI receive coil to protect the equipment and patient. Conventionally, Q-spoiling is performed using a PIN diode switch that draws significant current. In this work, a Q-spoiling technique using a depletion-mode Gallium Nitride HEMT device was developed for coil detuning at both 1.5 T and 3 T MRI. The circuits with conventional PIN diode Q-spoiling and the GaN HEMT device were implemented on surface coils. SNR was measured and compared for all surfaces coils. At both 1.5 T and 3 T, comparable SNR was achieved for all coils with the proposed technique and conventional Q-spoiling. The GaN HEMT device has significantly reduced the required power for Q-spoiling. The GaN HEMT device also provides useful safety features by detuning the coil when unpowered.

  9. Coenzyme Q and Mitochondrial Disease

    ERIC Educational Resources Information Center

    Quinzii, Catarina M.; Hirano, Michio

    2010-01-01

    Coenzyme Q[subscript 10] (CoQ[subscript 10]) is an essential electron carrier in the mitochondrial respiratory chain and an important antioxidant. Deficiency of CoQ[subscript 10] is a clinically and molecularly heterogeneous syndrome, which, to date, has been found to be autosomal recessive in inheritance and generally responsive to CoQ[subscript…

  10. Coenzyme Q and Mitochondrial Disease

    ERIC Educational Resources Information Center

    Quinzii, Catarina M.; Hirano, Michio

    2010-01-01

    Coenzyme Q[subscript 10] (CoQ[subscript 10]) is an essential electron carrier in the mitochondrial respiratory chain and an important antioxidant. Deficiency of CoQ[subscript 10] is a clinically and molecularly heterogeneous syndrome, which, to date, has been found to be autosomal recessive in inheritance and generally responsive to CoQ[subscript…

  11. Split Q-balls

    NASA Astrophysics Data System (ADS)

    Bazeia, D.; Losano, L.; Marques, M. A.; Menezes, R.

    2017-02-01

    We investigate the presence of non-topological solutions of the Q-ball type in (1 , 1) spacetime dimensions. The model engenders the global U (1) symmetry and is of the k-field type, since it contains a new term, of the fourth-order power in the derivative of the complex scalar field. It supports analytical solution of the Q-ball type which is stable quantum mechanically. The new solution engenders an interesting behavior, with the charge and energy densities unveiling a splitting profile.

  12. The q-harmonic oscillators, q-coherent states and the q-symplecton

    NASA Technical Reports Server (NTRS)

    Biedenharn, L. C.; Lohe, M. A.; Nomura, Masao

    1993-01-01

    The recently introduced notion of a quantum group is discussed conceptually and then related to deformed harmonic oscillators ('q-harmonic oscillators'). Two developments in applying q-harmonic oscillators are reviewed: q-coherent states and the q-symplecton.

  13. q-bosons and the q-analogue quantized field

    NASA Technical Reports Server (NTRS)

    Nelson, Charles A.

    1995-01-01

    The q-analogue coherent states are used to identify physical signatures for the presence of a 1-analogue quantized radiation field in the q-CS classical limits where the absolute value of z is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/absolute value of z) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H(sub N) = h(omega)(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that (Delta N)(exp 2)/ (N) approaches 0 as the absolute value of z approaches infinity. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, phi(sub q), still exhibits normal classical behavior. The standard number-phase uncertainty-relation, Delta(N) Delta phi(sub q) = 1/2, and the approximate commutation relation, (N, phi(sub q)) = i, still hold for the single-mode q-analogue quantized field. So, N and phi(sub q) are almost canonically conjugate operators in the q-CS classical limit. The q-analogue CS's minimize this uncertainty relation for moderate (absolute value of z)(exp 2).

  14. Propagating q-field and q-ball solution

    NASA Astrophysics Data System (ADS)

    Klinkhamer, F. R.; Volovik, G. E.

    2017-06-01

    One possible solution of the cosmological constant problem involves a so-called q-field, which self-adjusts so as to give a vanishing gravitating vacuum energy density (cosmological constant) in equilibrium. We show that this q-field can manifest itself in other ways. Specifically, we establish a propagating mode (q-wave) in the nontrivial vacuum and find a particular soliton-type solution in flat spacetime, which we call a q-ball by analogy with the well-known Q-ball solution. Both q-waves and q-balls are expected to play a role for the equilibration of the q-field in the very early universe.

  15. Polarization-switchable Q-switched DFB fiber laser.

    PubMed

    Fraser, Alex; Bernier, Martin; Deschênes, Jean-Daniel; Weynant, Eric; Genest, Jérome; Vallée, Réal

    2010-04-01

    A polarization switchable Q-switched distributed feedback (DFB) fiber laser is presented. This what we believe to be a new Q-switching method allows one to obtain linearly polarized laser emission in either x or y direction. The principle of this method is based on a variable birefringent phase shift induced by a lateral stress applied at a precise location along a fiber Bragg grating by a specially designed hyper-elastic device. A piezoelectric actuator controls the amount of stress delivered to the fiber, thus allowing a precise and rapid tuning of the cavity Q-factor.

  16. The q-Fourier transformation of q-generalized functions

    SciTech Connect

    Ol'shanetskii, M A; Rogov, V-B K

    1999-06-30

    A study is made of functions on the lattice generated by the integer powers of q{sup 2}, 0<q<1. A q-analogue of the Fourier transformation is constructed based on the Jackson integral in the space of generalized functions on the lattice.

  17. High-Q gold and silicon nitride bilayer nanostrings

    NASA Astrophysics Data System (ADS)

    Biswas, T. S.; Suhel, A.; Hauer, B. D.; Palomino, A.; Beach, K. S. D.; Davis, J. P.

    2012-08-01

    Low-mass, high-Q, silicon nitride nanostrings are at the cutting edge of nanomechanical devices for sensing applications. Here we show that the addition of a chemically functionalizable gold overlayer does not adversely affect the Q of the fundamental out-of-plane mode. Instead the device retains its mechanical responsiveness while gaining sensitivity to molecular bonding. Furthermore, differences in thermal expansion within the bilayer give rise to internal stresses that can be electrically controlled. In particular, an alternating current (AC) excites resonant motion of the nanostring. This AC thermoelastic actuation is simple, robust, and provides an integrated approach to sensor actuation.

  18. q-bosons and the q-analogue quantized field

    SciTech Connect

    Nelson, C.A.

    1994-12-31

    The q-analogue coherent states {vert_bar}z >{sub q} are used to identify physical signatures for the presence of a q-analogue quantized radiation field in the {vert_bar} >{sub q} classical limit where {vert_bar}z{vert_bar} is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/{vert_bar}z{vert_bar}) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H{sub N} = {Dirac_h}{omega}(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that ({Delta}N){sup 2}/ {yields} 0 as {vert_bar}z{vert_bar} {yields} {infinity}. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, {phi}{sub q}, still exhibits normal classical behavior. The standard number-phase uncertainty-relation, {Delta}N {Delta}{phi}{sub q} = 1/2, and the approximate commutation relation, [N,{phi}{sub q}] = i, still hold for the single-mode q-analogue quantized field. So, N and {phi}{sub q} are almost canonically conjugate operators in the {vert_bar}z >{sub q} classical limit. The {vert_bar}z >{sub q} CS`s minimize this uncertainty relation for moderate {vert_bar}z{vert_bar}{sup 2}.

  19. Photovoltaic device

    DOEpatents

    Reese, Jason A.; Keenihan, James R.; Gaston, Ryan S.; Kauffmann, Keith L.; Langmaid, Joseph A.; Lopez, Leonardo C.; Maak, Kevin D.; Mills, Michael E.; Ramesh, Narayan; Teli, Samar R.

    2015-06-02

    The present invention is premised upon an improved photovoltaic device ("PV device"), more particularly to an improved photovoltaic device with a multilayered photovoltaic cell assembly and a body portion joined at an interface region and including an intermediate layer, at least one interconnecting structural member, relieving feature, unique component geometry, or any combination thereof.

  20. Photovoltaic device

    DOEpatents

    Reese, Jason A; Keenihan, James R; Gaston, Ryan S; Kauffmann, Keith L; Langmaid, Joseph A; Lopez, Leonardo; Maak, Kevin D; Mills, Michael E; Ramesh, Narayan; Teli, Samar R

    2017-03-21

    The present invention is premised upon an improved photovoltaic device ("PV device"), more particularly to an improved photovoltaic device with a multilayered photovoltaic cell assembly and a body portion joined at an interface region and including an intermediate layer, at least one interconnecting structural member, relieving feature, unique component geometry, or any combination thereof.

  1. Photovoltaic device

    DOEpatents

    Reese, Jason A.; Keenihan, James R.; Gaston, Ryan S.; Kauffmann, Keith L.; Langmaid, Joseph A.; Lopez, Leonardo C.; Maak, Kevin D.; Mills, Michael E.; Ramesh, Narayan; Teli, Samar R.

    2015-09-01

    The present invention is premised upon an improved photovoltaic device ("PV device"), more particularly to an improved photovoltaic device (10) with a multilayered photovoltaic cell assembly (100) and a body portion (200) joined at an interface region (410) and including an intermediate layer (500), at least one interconnecting structural member (1500), relieving feature (2500), unique component geometry, or any combination thereof.

  2. Symposium Q: Magnetic Thin Films, Heterostructures, and Device Materials

    DTIC Science & Technology

    2007-05-22

    Quantum so accounting, for example, for little change of TSP and TMR when Well in fully Epitaxial Double Barrier Magnetic Tunnel Co is diluted with...improvement of the 366 quality of the quantum well layer will provides us the realization of SrTiO3 which is formed from localized 3d states of Ti and...and Tampa, New York. magnetic moments as a function of volume as well as band structures Quantum Dots of diluted magnetic semiconductor (DMS) are

  3. Preliminary Planet Population Statistics With Kepler Q1-Q16

    NASA Astrophysics Data System (ADS)

    Burke, Christopher J.; Mullally, Fergal; Christiansen, Jessie; Huber, Daniel; Coughlin, Jeffrey; Thompson, Susan E.; Jenkins, Jon Michael; Batalha, Natalie M.

    2014-06-01

    We present preliminary extrasolar planet population statistics from analysis of the Kepler Q1-Q16 planet candidate sample. The analysis takes advantage of the recent work on the Q1-Q16 Kepler planet candidate sample, extensive Monte-Carlo transit signal injection and recovery tests of the Kepler Pipeline, and updates to the stellar parameters provided by the Kepler Stellar Working Group. We also explore the sensitivity of the results to alternative inputs by considering a machine learning generated planet sample, systematics in the stellar sample properties, orbital eccentricity, and false positive rates.

  4. Gauged Q-balls

    NASA Technical Reports Server (NTRS)

    Lee, Kimyeong; Stein-Schabes, Jaime A.; Watkins, Richard; Widrow, Lawrence M.

    1988-01-01

    Classical non-topological soliton configurations are considered within the theory of a complex scalar field with a gauged U symmetry. Their existence and stability against dispersion are demonstrated and some of their properties are investigated analytically and numerically. The soliton configuration is such that inside the soliton the local U symmetry is broken, the gauge field becomes massive and for a range of values of the coupling constants the soliton becomes a superconductor pushing the charge to the surface. Furthermore, because of the repulsive Coulomb force, there is a maximum size for these objects, making impossible the existence of Q-matter in bulk form. Also briefly discussed are solitons with fermions in a U gauge theory.

  5. The 5q-anomaly.

    PubMed

    Van den Berghe, H; Vermaelen, K; Mecucci, C; Barbieri, D; Tricot, G

    1985-07-01

    A deletion of the long arm of chromosome #5 (5q-) occurs nonrandomly in human malignancies. As a rule, the deletion is interstitial; the distal breakpoint by conventional techniques is usually in band q32, the proximal breakpoints in q12 or q14. Variant breakpoints occur in less than 10% of all cases. As the sole anomaly, 5q- is characteristically found in refractory anemia with or without excess of blasts. It can occur as the sole anomaly in de novo or secondary acute nonlymphocytic leukemia, but is usually accompanied in those disorders by other chromosome changes that are also nonrandomly distributed. In addition, it can be found in lymphoproliferative disorders, and occasionally, also in solid tumors. The 5q- myelodysplastic syndrome typically occurs in older age groups, particularly in females. Characteristic features are macrocytic anemia, normal or elevated platelets in the presence of megakaryocytic anomalies, and a mild clinical course. In cases with 5q- only, transformation into ANLL occurs rarely. Additional chromosome anomalies and male sex are prognostically unfavorable signs. Sex ratio is also at the disadvantage of females in de novo 5q- ANLL, and the latter disorder can occur without being preceded by a myelodysplastic phase. A myelodysplastic phase usually precedes 5q- secondary leukemia, in males as well as in females, and additional chromosome anomalies, especially of chromosome #7, are almost invariably present in those cases. We conclude that 5q- is the most frequently occurring single chromosome anomaly in secondary leukemia. Furthermore, the resemblance between de novo and secondary 5q- MDS and ANLL is striking; clinically, as well as cytogenetically, they are indistinguishable, suggesting that all de novo cases may be due to environmental (chemical) carcinogens. Response to treatment and prognosis are very poor with current therapeutic regimens in de novo as well as in secondary 5q- ANLL. Morphologically, these ANLLs fall into all FAB

  6. Q fever — a review

    PubMed Central

    Marrie, Thomas J.

    1990-01-01

    Q or “query” fever is a zoonosis caused by the organism Coxiella burnetii. Cattle, sheep and goats are the most common reservoirs of this organism. The placenta of infected animals contains high numbers (up to 109/g) of C. burnetii. Aerosols occur at the time of parturition and man becomes infected following inhalation of the microorganism. The spectrum of illness in man is wide and consists of acute and chronic forms. Acute Q fever is most often a self-limited flu-like illness but may include pneumonia, hepatitis, or meningoencephalitis. Chronic Q fever almost always means endocarditis and rarely osteomyelitis. Chronic Q fever is not known to occur in animals other than man. An increased abortion and stillbirth rate are seen in infected domestic ungulates. Four provinces (Nova Scotia, New Brunswick, Ontario and Alberta) reported cases of Q fever in 1989. A vaccine for Q fever has recently been licensed in Australia. ImagesFigure 1. PMID:17423643

  7. The ‘PREXCEL-Q Method’ for qPCR

    PubMed Central

    Gallup, Jack M.; Ackermann, Mark R.

    2008-01-01

    The purpose of this manuscript is to describe a reliable approach to quantitative real-time polymerase chain reaction (qPCR) assay development and project management, which is currently embodied in the Excel 2003-based software program named “PREXCEL-Q” (P-Q) (formerly known as “FocusField2-6Gallup-qPCRSet-upTool-001,” “FF2-6-001 qPCR set-up tool” or “Iowa State University Research Foundation [ISURF] project #03407”). Since its inception from 1997-2007, the program has been well-received and requested around the world and was recently unveiled by its inventor at the 2008 Cambridge Healthtech Institute’s Fourth Annual qPCR Conference in San Diego, CA. P-Q was subsequently mentioned in a review article by Stephen A. Bustin, an acknowledged leader in the qPCR field. Due to its success and growing popularity, and the fact that P-Q introduces a unique/defined approach to qPCR, a concise description of what the program is and what it does has become important. Sample-related inhibitory problems of the qPCR assay, sample concentration limitations, nuclease-treatment, reverse transcription (RT) and master mix formulations are all addressed by the program, enabling investigators to quickly, consistently and confidently design uninhibited, dynamically-sound, LOG-linear-amplification-capable, high-efficiency-of-amplification reactions for any type of qPCR. The current version of the program can handle an infinite number of samples. PMID:19759920

  8. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey L. (Inventor)

    2017-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  9. Sealing device

    SciTech Connect

    Garcia-Crespo, Andres Jose

    2013-12-10

    A sealing device for sealing a gap between a dovetail of a bucket assembly and a rotor wheel is disclosed. The sealing device includes a cover plate configured to cover the gap and a retention member protruding from the cover plate and configured to engage the dovetail. The sealing device provides a seal against the gap when the bucket assemply is subjected to a centrifugal force.

  10. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey (Inventor)

    2015-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  11. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey L. (Inventor)

    2016-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  12. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey L. (Inventor)

    2017-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  13. Q2/Q3 2016 Solar Industry Update

    SciTech Connect

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-10-11

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q2 and Q3 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  14. Q3/Q4 2016 Solar Industry Update

    SciTech Connect

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-12-21

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q3 and Q4 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  15. q-plate for the Generation of Terahertz Cylindrical Vector Beams Fabricated by 3D Printing

    NASA Astrophysics Data System (ADS)

    Hernandez-Serrano, A. I.; Castro-Camus, E.; Lopez-Mago, D.

    2017-08-01

    We present the design, fabrication, and characterization of a q-plate with continuous birefringence variation at terahertz frequencies. This q-plate was fabricated by three-dimensional printing and is a simple solution for the generation of cylindrical vector beams. This device can find a number of applications in future terahertz technologies such as telecommunications.

  16. BRAKE DEVICE

    DOEpatents

    O'Donnell, T.J.

    1959-03-10

    A brake device is described for utilization in connection with a control rod. The device comprises a pair of parallelogram link mechanisms, a control rod moveable rectilinearly therebetween in opposite directions, and shoes resiliently supported by the mechanism for frictional engagement with the control rod.

  17. Josephson Devices

    NASA Astrophysics Data System (ADS)

    Barone, Antonio; Pagano, Sergio

    In this chapter we briefly review the main applications of Josephson effect together with the most successful devices realized. We will give an overview of the various devices, providing also some basic concepts of the underlying physical mechanisms involved, and the associated limit performances. Some considerations on the concrete possibilities of successful "market ready" implementation will also be given.

  18. Optoelectronic devices

    NASA Astrophysics Data System (ADS)

    Sperling, Leslie H.; Murphy, Clarence J.; Rosen, Warren A.; Jain, Himanshu

    1990-07-01

    This invention relates to acrylic polymers and more specifically to polyacrylamides and polyacrylates such as poly(2-((N-2-methyl-5-nitrophenylamino) ethyl acrylate)) and poly((N-2-methyl-4-nitrophenyl)acrylamide). These acrylic polymers are particularly useful as nonlinear optical components in various electrical devices for processing optical signals including interferometors, optical switches, optical amplifiers, generators, computational devices and the like.

  19. Electrochromic devices

    DOEpatents

    Allemand, Pierre M.; Grimes, Randall F.; Ingle, Andrew R.; Cronin, John P.; Kennedy, Steve R.; Agrawal, Anoop; Boulton, Jonathan M.

    2001-01-01

    An electrochromic device is disclosed having a selective ion transport layer which separates an electrochemically active material from an electrolyte containing a redox active material. The devices are particularly useful as large area architectural and automotive glazings due to there reduced back reaction.

  20. Superconducting devices

    SciTech Connect

    Ruggiero, S.T. . Dept. of Physics); Rudman, D.A. . Dept. of Materials Science and Engineering)

    1990-01-01

    This book presents a discussion of the theory, fabrication, and qualification of superconducting device elements and integrated circuitry. A look at issues key to the development of practical superconducting devices and systems is presented. Integrated systems, including the fabrication and application of SQUIDs, Josephson arrays, microwave detectors, digital signal processors and computers, and analog signal processors are discussed.

  1. Comparative Efficacy of the Air-Q Intubating Laryngeal Airway during General Anesthesia in Pediatric Patients: A Systematic Review and Meta-Analysis

    PubMed Central

    Ahn, Eun Jin; Choi, Geun Joo; Kang, Hyun; Baek, Chong Wha; Jung, Yong Hun; Woo, Young Cheol; Bang, Si Ra

    2016-01-01

    Air-Q® (air-Q) is a supraglottic airway device which can be used as a guidance of intubation in pediatric as well as in adult patients. We evaluated the efficacy and safety of air-Q compared to other airway devices during general anesthesia in pediatric patients by conducting a systematic review and meta-analysis. A total of 10 studies including 789 patients were included in the final analysis. Compared with other supraglottic airway devices, air-Q showed no evidence for a difference in leakage pressure and insertion time. The ease of insertion was significantly lower than other supraglottic airway devices. The success rate of intubation was significantly lower than other airway devices. However, fiberoptic view was better through the air-Q than other supraglottic airway devices. Therefore, air-Q could be a safe substitute for other airway devices and may provide better fiberoptic bronchoscopic view. PMID:27419134

  2. PLASMA DEVICE

    DOEpatents

    Gow, J.D.; Wilcox, J.M.

    1961-12-26

    A device is designed for producing and confining highenergy plasma from which neutrons are generated in copious quantities. A rotating sheath of electrons is established in a radial electric field and axial magnetic field produced within the device. The electron sheath serves as a strong ionizing medium to gas introdueed thereto and also functions as an extremely effective heating mechanism to the resulting plasma. In addition, improved confinement of the plasma is obtained by ring magnetic mirror fields produced at the ends of the device. Such ring mirror fields are defined by the magnetic field lines at the ends of the device diverging radially outward from the axis of the device and thereafter converging at spatial annular surfaces disposed concentrically thereabout. (AFC)

  3. Applications and Methods of Operating a Three-dimensional Nano-electro-mechanical Resonator and Related Devices

    NASA Technical Reports Server (NTRS)

    Kaul, Anupama B. (Inventor); Epp, Larry W. (Inventor); Bagge, Leif (Inventor)

    2013-01-01

    Carbon nanofiber resonator devices, methods for use, and applications of said devices are disclosed. Carbon nanofiber resonator devices can be utilized in or as high Q resonators. Resonant frequency of these devices is a function of configuration of various conducting components within these devices. Such devices can find use, for example, in filtering and chemical detection.

  4. Gas sensing with acoustic devices

    SciTech Connect

    Martin, S.J.; Frye, G.C.; Spates, J.J.; Butler, M.A.

    1996-12-31

    A survey is made of acoustic devices that are suitable as gas and vapor sensors. This survey focuses on attributes such as operating frequency, mass sensitivity, quality factor (Q), and their ability to be fabricated on a semiconductor substrate to allow integration with electronic circuitry. The treatment of the device surface with chemically-sensitive films to detect species of interest is discussed. Strategies for improving discrimination are described, including sensor arrays and species concentration and separation schemes. The advantages and disadvantages of integrating sensors with microelectronics are considered, along with the effect on sensitivity of scaling acoustic gas sensors to smaller size.

  5. Excitonic devices

    NASA Astrophysics Data System (ADS)

    Butov, L. V.

    2017-08-01

    Indirect excitons can be controlled by voltage, can travel over large distances before recombination, and can cool down close to the temperature of semiconductor crystal lattice and below the temperature of quantum degeneracy. These properties form the basis for the development of excitonic devices with indirect excitons. In this contribution, we overview our studies of excitonic devices. We present traps, lattices, conveyers, and ramps for studying basic properties of cold indirect excitons - cold bosons in semiconductor materials. We also present proof-of-principle demonstration for excitonic signal processing devices.

  6. High-Q terahertz reconfigurable metamaterials using graphene

    NASA Astrophysics Data System (ADS)

    Arezoomandan, Sara; Sensale Rodriguez, Berardi

    2016-09-01

    We propose and discuss high-Q reconfigurable metamaterials based on graphene. The key components of the device are periodic concentric metallic ring resonators with interdigitated fingers, which are placed in-between the rings and provide for the large Q in the metamaterial, as well as several strategically located gaps where active graphene sheets are placed. We can easily adjust the frequency response of the metamaterial by means of varying a couple of parameters, such as the ring dimensions, number of fingers, etc., but also dynamically by means of varying conductivity in graphene.

  7. Cleaning devices

    NASA Technical Reports Server (NTRS)

    Schneider, Horst W. (Inventor)

    1980-01-01

    Cleaning devices are described which include a vacuum cleaner wherein electrostatically charged brushes that brush dirt off a floor, are electrically grounded to remove charges that could tend to hold dirt to the brushes.

  8. Device Performance

    SciTech Connect

    Not Available

    2006-06-01

    In the Device Performance group, within the National Center for Photovoltaic's Measurements and Characterization Division, we measure the performance of PV cells and modules with respect to standard reporting conditions--defined as a reference temperature (25 C), total irradiance (1000 Wm-2), and spectral irradiance distribution (IEC standard 60904-3). Typically, these are ''global'' reference conditions, but we can measure with respect to any reference set. To determine device performance, we conduct two general categories of measurements: spectral responsivity (SR) and current versus voltage (I-V). We usually perform these measurements using standard procedures, but we develop new procedures when required by new technologies. We also serve as an independent facility for verifying device performance for the entire PV community. We help the PV community solve its special measurement problems, giving advice on solar simulation, instrumentation for I-V measurements, reference cells, measurement procedures, and anomalous results. And we collaborate with researchers to analyze devices and materials.

  9. Deletion (11)(q14.1q21)

    SciTech Connect

    Stratton, R.F.; Lazarus, K.H.; Ritchie, E.J.L.; Bell, A.M.

    1994-02-01

    The authors report on a 4-year-old girl with moderate development delay, horseshoe kidney, bilateral duplication of the ureters with right upper pole obstruction, hydronephrosis and nonfunction, and subsequent Wilms tumor of the right lower pole. She had an interstitial deletion of the long arm of chromosome 11 involving the region 11(q14.1q21). 22 refs., 2 figs., 1 tab.

  10. Device Demonstration

    DTIC Science & Technology

    2006-12-31

    effecting change in the electrical properties of the material. Due to the heating requirement in setting the state, stray radiation does not affect the...device as in traditional binary RAM, thus giving the device radiation-hard properties . Uniformity of the heater elements at a small size below 100 nm is...Molybdenum was chosen for the cathode tube material because it has a low sputtering coefficient, and it’s high temperature properties .. The tubes are

  11. A Q-Modulation Technique for Efficient Inductive Power Transmission.

    PubMed

    Kiani, Mehdi; Lee, Byunghun; Yeon, Pyungwoo; Ghovanloo, Maysam

    2015-12-01

    A fully-integrated power management ASIC for efficient inductive power transmission has been presented capable of automatic load transformation using a method, called Q-modulation. Q-modulation is an adaptive scheme that offers load matching against a wide range of loading (RL ) and coupling distance (d23 ) variations in inductive links to maintain high power transfer efficiency (PTE). It is suitable for inductive powering implantable microelectronic devices (IMDs), recharging mobile electronics, and electric vehicles. In Q-modulation, the zero-crossings of the induced current in the receiver (Rx) LC-tank are detected and a low-loss switch chops the Rx LC-tank for part of the power carrier cycle to form a high-Q LC-tank and store the maximum energy, which is then transferred to RL by opening the switch. By adjusting the duty cycle (D), the loaded-Q of the Rx LC-tank can be dynamically modulated to compensate for variations in RL . A Q-modulation power management (QMPM) prototype chip was fabricated in a 0.35-μm standard CMOS process, occupying 4.8 mm(2). In a 1.45 W wireless power transfer setup, using a class-E power amplifier (PA) operating at 2 MHz, the QMPM successfully increased the inductive link PTE and the overall power efficiency by 98.5% and 120.7% at d23 = 8 cm, respectively, by compensating for 150 Ω variation in RL at D = 45%.

  12. Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.

    PubMed

    Auranen, M; Nieminen, T; Majuri, S; Vanhala, R; Peltonen, L; Järvelä, I

    2000-05-01

    The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1-8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.

  13. Microchannel devices

    SciTech Connect

    Alman, David E.; Wilson, Rick D.

    2001-09-01

    The fabrication of stainless steel microchannel heat exchangers was examined through microlamination, the process of diffusion bonding precision machined metallic foils. The influence of diffusion bonding parameters, as well as the device geometry on the strength of the bond between the foils and embedded channel integrity, was investigated. During diffusion bonding, high temperatures and/or pressures result in well bonded foils, but these conditions cause the embedded channels to deform, which will degrade the efficiency of fluid flow through the channels. Alternatively, low temperatures and/or pressures result in undeformed channels but weakly bonded foils. This causes failure of the device due to fluid leakage. Thus, a processing envelope exists for producing a sound device with no fluid leakage and no degradation of fluid flow properties. The theoretical limit on aspect ratio within two-fluid counter-flow microchannel heat exchangers was also investigated. A counter-flow device is comprised of alternating layers of microchannels, which allow the two fluids to flow in opposite directions separated by fins. A theoretical model for interpreting the span of the fin as a function of the fin thickness was established. The model was verified experimentally by fabricating specimens to simulate the counter-flow device. The results of these investigations were used to aid in the design and processing of prototype microchannel devices.

  14. A constitutional 5q23 deletion.

    PubMed Central

    Rivera, H; Simi, P; Rossi, S; Pardelli, L; Di Paolo, M C

    1990-01-01

    A 14 month old girl was found to have a deletion of the whole of band 5q23. By comparing 19 other cases monosomic for a part of the 5q13-q31 segment, the constitutional 5q interstitial deletions fall into two groups: adult patients with Gardner-like symptoms and mental retardation associated with deletion 5q21-q22, and patients (mostly children) with unspecific signs and symptoms and different deletions. Images PMID:2325108

  15. Graphene actively Q-switched lasers

    NASA Astrophysics Data System (ADS)

    Li, Diao; Xue, Hui; Qi, Mei; Wang, Yadong; Aksimsek, Sinan; Chekurov, Nikolai; Kim, Wonjae; Li, Changfeng; Riikonen, Juha; Ye, Fangwei; Dai, Qing; Ren, Zhaoyu; Bai, Jintao; Hasan, Tawfique; Lipsanen, Harri; Sun, Zhipei

    2017-06-01

    Graphene electro-optic modulators (GEOMs) are emerging as a viable alternative to conventional material-based modulators mainly due to their broadband and ultrafast performance. These GEOMs with combined advantages of small footprint and low energy consumption can potentially enable various high-performance applications that are not possible using conventional approaches. Here, we report the first actively Q-switched lasers with a GEOM. In contrast to the previously reported lasers that are passively modulated by two-dimensional layered material-based saturable absorbers, our actively modulated laser concept represents significant advantages, such as electrically tunable output parameters (e.g. output repetition rate, pulse duration and pulse energy) and electro-optical synchronization. Using a single GEOM, we generate broadband Q-switched pulses at  ∼1.55 and 2 μm with output energies of up to 123 nJ. This indicates the broadband pulse generation capability of the graphene-based active devices, superior to widely used bulk material-based active modulation approaches. Our results demonstrate a simple and viable design towards broadband, high-repetition-rate, electrically modulated ultrafast lasers for various applications, such as telecommunications and spectroscopy.

  16. PLASMA DEVICE

    DOEpatents

    Baker, W.R.; Brathenahl, A.; Furth, H.P.

    1962-04-10

    A device for producing a confined high temperature plasma is described. In the device the concave inner surface of an outer annular electrode is disposed concentrically about and facing the convex outer face of an inner annular electrode across which electrodes a high potential is applied to produce an electric field there between. Means is provided to create a magnetic field perpendicular to the electric field and a gas is supplied at reduced pressure in the area therebetween. Upon application of the high potential, the gas between the electrodes is ionized, heated, and under the influence of the electric and magnetic fields there is produced a rotating annular plasma disk. The ionized plasma has high dielectric constant properties. The device is useful as a fast discharge rate capacitor, in controlled thermonuclear research, and other high temperature gas applications. (AEC)

  17. Interstitial deletions 4q21.1q25 and 4q25q27: Phenotypic variability and relation to Rieger anomaly

    SciTech Connect

    Kulharya, A.S.; Schneider, N.R.; Tonk, V.

    1995-01-16

    We describe clinical and chromosomal findings in two patients with del(4q). Patient 1, with interstitial deletion (4)(q21.1q25), had craniofacial and skeletal anomalies and died at 8 months hydrocephalus. Patient 2, with interstitial deletion (4)(q25q27), had craniofacial and skeletal anomalies with congenital hypotonia and developmental delay. These patients shared certain manifestations with other del(4q) patients but did not have Rieger anomaly. Clinical variability among patients with interstitial deletions of 4q may be related to variable expression, variable deletion, or imprinting of genes within the 4q region. 15 refs., 4 figs., 1 tab.

  18. Analytical Device

    NASA Technical Reports Server (NTRS)

    1983-01-01

    In the mid 60s under contract with NASA, Dr. Benjamin W. Grunbaum was responsible for the development of an automated electrophoresis device that would work in the weightless environment of space. The device was never used in space but was revived during the mid 70s as a technology utilization project aimed at an automated system for use on Earth. The advanced system became known as the Grunbaum System for electrophoresis. It is a versatile, economical assembly for rapid separation of specific blood proteins in very small quantities, permitting their subsequent identification and quantification.

  19. Flux generation in ultra-low- q tokamak discharges

    SciTech Connect

    Schmid, P.; Barrick, G.; Greene, P. ); Robertson, S. )

    1991-04-01

    Spontaneous generation of toroidal flux is observed in a reversed-field pinch device operated as an ultra-low-{ital q} tokamak with a safety factor on axis of 1/4. An initial toroidal bias field of 150 G is increased to 600 G on axis in 300 {mu}sec while the field at the wall is held nearly constant. Sawteeth are observed, which indicate cyclic magnetic reconnection.

  20. Cleaning devices

    NASA Technical Reports Server (NTRS)

    Schneider, Horst W. (Inventor)

    1981-01-01

    Cleaning devices are described which include a vacuum cleaner nozzle with a sharp rim for directing incoming air down against the floor; a vacuum cleaner wherein electrostatically charged brushes that brush dirt off a floor, are electrically grounded to remove charges that could tend to hold dirt to the brushes; a vacuum cleaner head having slots that form a pair of counter-rotating vortices, and that includes an outlet that blows a stream of air at the floor region which lies between the vortices; a cleaning device that sweeps a group of brushes against the ground along a first direction, and then sweeps them along the same ground area but in a second direction angled from the first by an amount such as 90.degree., to sweep up particles lying in crevices extending along any direction; a device that gently cleans a surface to remove bacteria for analysis, including an inclined wall along which cleaning fluid flows onto the surface, a vacuum chamber for drawing in the cleaning fluid, and a dividing wall spaced slightly from the surface to separate the fluid source from the vacuum cleaner chamber; and a device for providing pulses of pressured air including a chamber to which pressured air is supplied, a ball that circulates around the chamber to repeatedly close an outlet, and an air source that directs air circumferentially to move the ball around the chamber.

  1. Detection device

    DOEpatents

    Smith, Jay E.

    1984-01-01

    The present invention is directed to a detection device comprising: (1) an entrance chamber, (2) a central chamber, and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  2. Detection device

    DOEpatents

    Smith, J.E.

    1981-02-27

    The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  3. Electrochemical device

    DOEpatents

    Grimes, Patrick G.; Einstein, Harry; Bellows, Richard J.

    1988-01-12

    A tunnel protected electrochemical device features channels fluidically communicating between manifold, tunnels and cells. The channels are designed to provide the most efficient use of auxiliary power. The channels have a greater hydraulic pressure drop and electrical resistance than the manifold. This will provide a design with the optimum auxiliary energy requirements.

  4. [Intrauterine devices].

    PubMed

    Delavest, P; Engelmann, P

    1980-12-11

    Medicated IUDs such as copper IUDs and progesterone-releasing IUDs represent a new development in this form of contraception. All IUDs act by causing an inflammatory reaction at the endometrial level. Techniques of insertion vary from one model to the other; insertion always requires an experienced practitioner, and postabortion or midmenstruation insertions are to be preferred. Pregnancy with IUD in situ is a rare occurrence; the IUD must then be immediately removed. Ectopic pregnancies are about 5-10% of all pregnancies with the device in situ. IUD complications are uterine perforation, mostly done at time of insertion, and pelvic infection which, if untreated, can cause infertility; this is the reason why an IUD is never recommended to a nullipara. Pain and bleeding are the most common side effects. When the strings of the device are not visible, translocation of the device inside the uterine cavity must be suspected. The choice of the wrong type of IUD or a bad insertion can cause spontaneous expulsion of the device. IUD wearers must be regularly seen by a doctor; there is no correlation between IUD use and cervical or endometrial carcinoma.

  5. Pure partial trisomy 4q syndrome in a child with der(9)ins(9;4)(q34.3;q26q35.2)mat.

    PubMed

    Topcu, V; Ilgin-Ruhi, H; Yurur-Kutlay, N; Ekici, C; Vicdan, A; Tukun, F A

    2014-01-01

    Pure partial trisomy 4q syndrome in a child with der(9)ins(9;4)(q34.3;q26q35.2)mat: Partial trisomy 4q is a rare chromosomal abnormality and mostly results from unbalanced inheritance of balanced parental chromosomal translocations. Here, we present a 5-year-old boy with partial trisomy 4q who exhibited distinctive features of 'pure' partial trisomy 4q syndrome including moderate mental and growth retardation, microcephaly, peculiar face appearance, tooth anomaly, cleft palate, language handicap, preaxial polydactyly, and urogenital anomaly. Karyotype analysis of the child revealed der(9)ins(9;4)(q34.3;q26q35.2) inherited from mother carrying ins(9;4)(q34.3;q26q35.2) resulting in trisomy of the 4q26qter segment. Whole chromosome painting, locus specific, and subtelomeric FISH analysis in mother proved that q26qter of the chromosome 4 segment was directly inserted into the telomeric sequence in chromosome 9, and depending on nature of the rearrangement in mother, karyotype of the child was determined to be pure partial 4q trisomy. This is the first report of this kind of rearrangement causing pure partial trisomy 4q with accompanying white matter change demonstrated by MRI and bilateral preaxial polydactyly of both hands.

  6. Q-enhanced racetrack microresonators

    NASA Astrophysics Data System (ADS)

    Chamorro-Posada, P.

    2017-03-01

    A Q-enhancement strategy for racetrack microresonators is put forward. The design is based on the modification of the resonator geometry in order to mitigate the two main sources of radiation loss in the presence of curved waveguides: the discontinuities at the junctions between straight waveguides and the bent sections, and the continuous loss at the curved waveguide sectors. At the same time, the modifications of the geometry do not affect the versatility of coupling of racetrack resonators in integrated optical circuits, which is their main advantage over ring microresonators. The proposal is applied to the design of high-Q racetrack resonators for the silicon nitride CMOS-compatible platform having bent radii amenable for large-scale photonic integration. Numerical calculations show over 100% improvement of the Q factor in Si3N4/SiO2 resonators.

  7. Josephson junction Q-spoiler

    DOEpatents

    Clarke, J.; Hilbert, C.; Hahn, E.L.; Sleator, T.

    1986-03-25

    An automatic Q-spoiler comprising at least one Josephson tunnel junction connected in an LC circuit for flow of resonant current therethrough. When in use in a system for detecting the magnetic resonance of a gyromagnetic particle system, a high energy pulse of high frequency energy irradiating the particle system will cause the critical current through the Josephson tunnel junctions to be exceeded, causing the tunnel junctions to act as resistors and thereby damp the ringing of the high-Q detection circuit after the pulse. When the current has damped to below the critical current, the Josephson tunnel junctions revert to their zero-resistance state, restoring the Q of the detection circuit and enabling the low energy magnetic resonance signals to be detected.

  8. Josephson junction Q-spoiler

    DOEpatents

    Clarke, John; Hilbert, Claude; Hahn, Erwin L.; Sleator, Tycho

    1988-01-01

    An automatic Q-spoiler comprising at least one Josephson tunnel junction connected in an LC circuit for flow of resonant current therethrough. When in use in a system for detecting the magnetic resonance of a gyromagnetic particle system, a high energy pulse of high frequency energy irradiating the particle system will cause the critical current through the Josephson tunnel junctions to be exceeded, causing the tunnel junctions to act as resistors and thereby damp the ringing of the high-Q detection circuit after the pulse. When the current has damped to below the critical current, the Josephson tunnel junctions revert to their zero-resistance state, restoring the Q of the detection circuit and enabling the low energy magnetic resonance signals to be detected.

  9. Partial monosomy of 7q32 in a case of de novo rcp(7;15)(q32;q15).

    PubMed Central

    D'Alessandro, E; Ligas, C; Lo Re, M L; Marcanio, M P; Gentile, T; Del Porto, G

    1994-01-01

    A de novo apparently balanced translocation between chromosomes 7 and 15 with breakpoints in q32 and q15 respectively is reported in a female child. Clinical features included general growth and psychomotor retardation, feeding problems, microcephaly, low set ears, a short neck, and brachydactyly. These findings suggested possible physical or functional partial monosomy of the 7q32 or 15q15 segments. The phenotype of this case is similar to other cases of 7q deletion. Images PMID:8064823

  10. Analysis of the vertices {Omega}{sub Q}*{Omega}{sub Q{phi}} and radiative decays {Omega}{sub Q}*{yields}{Omega}{sub Q{gamma}}

    SciTech Connect

    Wang Zhigang

    2010-02-01

    In this article, we study the vertices {Omega}{sub Q}*{Omega}{sub Q{phi}} with the light-cone QCD sum rules, then assume the vector meson dominance of the intermediate {phi}(1020), and calculate the radiative decays {Omega}{sub Q}*{yields}{Omega}{sub Q{gamma}}.

  11. Coenzyme q 10 : a review.

    PubMed

    Singh, Deependra; Jain, Vandana; Saraf, Swarnlata; Saraf, S

    2002-10-01

    Ubiquinone or Co Q(10) is essentially a vitamin like substance and is a cofactor of an enzyme. It is an integral part of the memberanes of mitocondria where it is involved in the energy production. It is a nutrient necessary for the function of every cell of the body especially vital organs of the body like heart, liver, brain etc. Studies have shown that coenzyme Q(10) alters the natural history of cardiovascular illness and has the potential of prevention of cardiovascular diseases through the inhibition of LDL cholesterol oxidation by maintenance of optimal cellular and mitochondrial function throughout the ravages of time internal and external stress.

  12. COENZYME Q 10 : A REVIEW

    PubMed Central

    Singh, Deependra; Jain, Vandana; Saraf, Swarnlata; Saraf, S

    2002-01-01

    Ubiquinone or Co Q10 is essentially a vitamin like substance and is a cofactor of an enzyme. It is an integral part of the memberanes of mitocondria where it is involved in the energy production. It is a nutrient necessary for the function of every cell of the body especially vital organs of the body like heart, liver, brain etc. Studies have shown that coenzyme Q10 alters the natural history of cardiovascular illness and has the potential of prevention of cardiovascular diseases through the inhibition of LDL cholesterol oxidation by maintenance of optimal cellular and mitochondrial function throughout the ravages of time internal and external stress. PMID:22557086

  13. Highest Weight Modules Over Quantum Queer Superalgebra {U_q(mathfrak {q}(n))}

    NASA Astrophysics Data System (ADS)

    Grantcharov, Dimitar; Jung, Ji Hye; Kang, Seok-Jin; Kim, Myungho

    2010-06-01

    In this paper, we investigate the structure of highest weight modules over the quantum queer superalgebra {U_q(mathfrak {q}(n))}. The key ingredients are the triangular decomposition of {U_q(mathfrak {q}(n))} and the classification of finite dimensional irreducible modules over quantum Clifford superalgebras. The main results we prove are the classical limit theorem and the complete reducibility theorem for {U_q(mathfrak {q}(n))}-modules in the category {mathcal {O}q^{≥ 0}}.

  14. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2008-08-19

    A laser device includes a virtual source configured to aim laser energy that originates from a true source. The virtual source has a vertical rotational axis during vertical motion of the virtual source and the vertical axis passes through an exit point from which the laser energy emanates independent of virtual source position. The emanating laser energy is collinear with an orientation line. The laser device includes a virtual source manipulation mechanism that positions the virtual source. The manipulation mechanism has a center of lateral pivot approximately coincident with a lateral index and a center of vertical pivot approximately coincident with a vertical index. The vertical index and lateral index intersect at an index origin. The virtual source and manipulation mechanism auto align the orientation line through the index origin during virtual source motion.

  15. LOADING DEVICE

    DOEpatents

    Ohlinger, L.A.

    1958-10-01

    A device is presented for loading or charging bodies of fissionable material into a reactor. This device consists of a car, mounted on tracks, into which the fissionable materials may be placed at a remote area, transported to the reactor, and inserted without danger to the operating personnel. The car has mounted on it a heavily shielded magazine for holding a number of the radioactive bodies. The magazine is of a U-shaped configuration and is inclined to the horizontal plane, with a cap covering the elevated open end, and a remotely operated plunger at the lower, closed end. After the fissionable bodies are loaded in the magazine and transported to the reactor, the plunger inserts the body at the lower end of the magazine into the reactor, then is withdrawn, thereby allowing gravity to roll the remaining bodies into position for successive loading in a similar manner.

  16. Electrooptical Devices.

    DTIC Science & Technology

    1981-09-30

    to monolithically integrate a passive waveguide with a GaInAsP/InP double-heterostructure laser for potential use in fabricating modulators and...HETEROSTRUCTURE DIODE LASERS 5 Ill. INTRACAVITY LOSS MODULATION OF GaInAsP DIODE LASERS 19 IV. MONOLITHIC INTEGRATION OF GaInAsP/InP LASERS WITH PASSIVE... integrating an electroabsorption modulator section with a waveguide section and an optical amplifier section as shown in Fig. III-1. The device

  17. Latching device

    NASA Technical Reports Server (NTRS)

    Ulrich, G. W. (Inventor)

    1975-01-01

    A latching device is suited for use in establishing a substantially motionless connection between a stationary receiver and a movable latching mechanism. The latching mechanism includes a pivotally supported restraining hook continuously urged into a capturing relationship with the receiver, characterized by a spring-biased pawl having a plurality of aligned teeth. The teeth are seated in the surface of the throat of the hook and positionable into restraining engagement with a rigid restraining shoulder projected from the receiver.

  18. Electrooptical Devices.

    DTIC Science & Technology

    1980-03-31

    Si N ’or Pl. The surface-related nature of the leakage currents was confirmed by testing the uncoated devices in several gaseous environments (O, NH ...later- tinre. Z-I.. Liau D. E. Mull .1. J. Ilsiebl J. N. Walpole T. A. Lind 711 G&InkA.P/ p I 643 6-C Fig. IV- t. Intensity distribution of an X-ray beam

  19. Coexistent t(8;21)(q22;q22) Translocation and 5q Deletion in Acute Myeloid Leukemia.

    PubMed

    Yamamoto, Katsuya; Yakushijin, Kimikazu; Sanada, Yukinari; Kawamoto, Shinichiro; Matsuoka, Hiroshi; Minami, Hironobu

    2015-01-01

    The t(8;21)(q22;q22) translocation is specifically observed in acute myeloid leukemia (AML) M2 subtype, whereas del(5q) is one of the most common cytogenetic aberrations in myelodysplastic syndromes (MDS). Thus, t(8;21)(q22;q22) and del(5q) appear to be mutually exclusive, and the association between them has not been characterized yet. Here, we report an 81-year-old woman with coexistent t(8;21)(q22;q22) and del(5q) at initial diagnosis. The bone marrow was infiltrated with 18.4% myeloblasts, and showed marked myeloid and erythroid dysplasia. Myeloblasts were positive for CD19 and CD56 as well as CD13, CD33, CD34 and HLA-DR. G-banding and spectral karyotyping showed 46,XX,del(5)(q?),t(8;21)(q22;q22)[18]/46,XX[2]. Both del(5)(q?) and t(8;21)(q22;q22) were present in a single clone. Fluorescence in situ hybridization (FISH) on metaphase spreads detected a RUNX1/RUNX1T1 fusion signal on the der(8)t(8;21)(q22;q22), and confirmed deletion of CSF1R signaling at 5q33-q34 on the del(5)(q?). Furthermore, FISH on interphase nuclei revealed that the RUNX1/RUNX1T1 fusion signal and deletion of CSF1R signaling were found in 66.0% and 58.0% of interphase cells, respectively, suggesting that del(5)(q?) occurred in cells with RUNX1/RUNX1T1. These results indicated a diagnosis of AML with t(8;21)(q22;q22)/RUNX1/RUNX1T1 rather than MDS, even though the percentage of bone marrow myeloblasts was less than 20%. Based on these findings, together with those of other reported cases, del(5q) seems to be an extremely rare but recurrent secondary aberration in AML with t(8;21)(q22;q22).

  20. Closure device

    SciTech Connect

    Sable, D. E.

    1985-06-11

    A closure device connectible to a well head through which the polished rod of a rod string extends into a well tubing for operating pump means for moving well fluids to a surface flow conductor, the closure device having a tubular ram provided with a packing or plug for closing an annular passage between the polished rod and a tubular body connected to the well head above a lateral port of the tubular body, the tubular ram and the tubular body having thread means for moving the plug between an operative lower position wherein it closes the annular passage when the rod string is stationary and on inoperative upper position; seal means between the ram and the polished rod spaced above the plug; and a plurality of independent seal means between the ram and the tubular body operative when the plug is in its inoperative position. The plug of the closure device is especially adapted to operate under high temperature and pressure conditions of the well, as during steam injection operations when the rod string is stationary, to protect the seal means from high pressures and temperatures as well as any fluids which may be corrosive or otherwise deleterious to the substance of which the seal means are made.

  1. Monosomy 6q1: Syndrome delineation

    SciTech Connect

    Romie, S.S.; Hartsfield, J.K. Jr.; Sutcliffe, M.J.

    1996-03-15

    We report on a girl with a de novo 6q1 interstitial deletion. To our knowledge, this is the second reported case with a deletion of 6q11-q15. We review the phenotype of monosomy 6q1. Our patient has manifestations similar to others with monosomy 6q1 including mental deficiency, growth retardation, short neck, and minor facila anomalies. 18 refs., 5 figs., 3 tabs.

  2. 4q32-q35 and 6q16-q22 are valuable candidate regions for split hand/foot malformation.

    PubMed

    Niedrist, Dunja; Lurie, Iosif W; Schinzel, Albert

    2009-08-01

    On the basis of the Human Cytogenetic Database, a computerized catalog of the clinical phenotypes associated with cytogenetically detectable human chromosome aberrations, we collected from the literature 102 cases with chromosomal aberrations and split hand/foot malformation or absent fingers/toes. Statistical analysis revealed a highly significant association (P<0.001) between the malformation and the chromosomal bands 4q32-q35, 5q15, 6q16-q22 and 7q11.2-q22 (SHFM1). Considering these findings, we suggest additional SHFM loci on chromosome 4q, 6q and probably 5q. The regions 4q and 6q have already been discussed in the literature as additional SHFM loci. We now show further evidence. In the proposed regions, there are interesting candidate genes such as, on 4q: HAND2, FGF2, LEF1 and BMPR1B; on 5q: MSX2, FLT4, PTX1 and PDLIM7; and on 6q: SNX3, GJA1, HEY2 and Tbx18.

  3. New multilevel codes over GF(q)

    NASA Technical Reports Server (NTRS)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1992-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  4. Q methodology in health economics.

    PubMed

    Baker, Rachel; Thompson, Carl; Mannion, Russell

    2006-01-01

    The recognition that health economists need to understand the meaning of data if they are to adequately understand research findings which challenge conventional economic theory has led to the growth of qualitative modes of enquiry in health economics. The use of qualitative methods of exploration and description alongside quantitative techniques gives rise to a number of epistemological, ontological and methodological challenges: difficulties in accounting for subjectivity in choices, the need for rigour and transparency in method, and problems of disciplinary acceptability to health economists. Q methodology is introduced as a means of overcoming some of these challenges. We argue that Q offers a means of exploring subjectivity, beliefs and values while retaining the transparency, rigour and mathematical underpinnings of quantitative techniques. The various stages of Q methodological enquiry are outlined alongside potential areas of application in health economics, before discussing the strengths and limitations of the approach. We conclude that Q methodology is a useful addition to economists' methodological armoury and one that merits further consideration and evaluation in the study of health services.

  5. Q fever in maritime Canada.

    PubMed Central

    Marrie, T. J.; Haldane, E. V.; Noble, M. A.; Faulkner, R. S.; Lee, S. H.; Gough, D.; Meyers, S.; Stewart, J.

    1982-01-01

    Only nine cases of Q fever were recorded in Canada in the 20 years prior to 1978. In the 18 months from August 1979 to January 1981 the disease was diagnosed serologically in six patients from the Maritime provinces. All were epidemiologically unrelated and none had been exposed to animals. Five had pneumonia and one had chronic Q fever with probable prosthetic valve endocarditis. Three of the five pneumonia patients presented with signs and symptoms of an acute lower respiratory tract infection and were indistinguishable clinically from other patients with atypical pneumonias. The other two with pneumonia presented with nonresolving pulmonary infiltrates and complained of decreased energy. Four of the five pneumonia patients responded well to treatment with erythromycin; the fifth required two courses of tetracycline. The patient with chronic Q fever had a large amount of cryoglobulins in his serum and evidence of immune complex disease. These cases indicate that Q fever should be considered as a possible cause of atypical pneumonia in Canada. Images FIG. 1 FIG. 2 FIG. 3 PMID:7074457

  6. Electrooptical Devices.

    DTIC Science & Technology

    1984-09-30

    Table 1-1 10 II-5 Calculated Ij as a Function of the Cap p-Doping 12 III-1 L-I Characteristics of the Five Mass-Transported BH Lasers with Different...343, a = 5.0 /im, W = 1.5 nmy and b = 2.0 pm 9 vni ELECTROOPTICAL DEVICES I. NEW DEVELOPMENTS IN MASS-TRANSPORTED GalnAsP/InP BURIED...HETEROSTRUCTURE LASERS As a potentially very important class of sources in fiber optical communication and inte- grated optics, GalnAsP/InP buried

  7. Electrospray device

    NASA Technical Reports Server (NTRS)

    Demmons, Nathaniel (Inventor); Martin, Roy (Inventor); Hruby, Vladimir (Inventor); Roy, Thomas (Inventor); Spence, Douglas (Inventor); Ehrbar, Eric (Inventor); Zwahlen, Jurg (Inventor)

    2011-01-01

    An electrospray device includes an electrospray emitter adapted to receive electrospray fluid; an extractor plate spaced from the electrospray emitter and having at least one aperture; and a power supply for applying a first voltage between the extractor plate and emitter for generating at least one Taylor cone emission through the aperture to create an electrospray plume from the electrospray fluid, the extractor plate as well as accelerator and shaping plates may include a porous, conductive medium for transporting and storing excess, accumulated electrospray fluid away from the aperture.

  8. Electrochromic device

    SciTech Connect

    Schwendemanm, Irina G; Polcyn, Adam D; Finley, James J; Boykin, Cheri M; Knowles, Julianna M

    2011-03-15

    An electrochromic device includes a first substrate spaced from a second substrate. A first conductive member is formed over at least a portion of the first substrate. A first electrochromic material is formed over at least a portion of the first conductive member. The first electrochromic material includes an organic material. A second conductive member is formed over at least a portion of the second substrate. A second electrochromic material is formed over at least a portion of the second conductive member. The second electrochromic material includes an inorganic material. An ionic liquid is positioned between the first electrochromic material and the second electrochromic material.

  9. Diversionary device

    DOEpatents

    Grubelich, Mark C.

    2001-01-01

    A diversionary device has a housing having at least one opening and containing a non-explosive propellant and a quantity of fine powder packed within the housing, with the powder being located between the propellant and the opening. When the propellant is activated, it has sufficient energy to propel the powder through the opening to produce a cloud of powder outside the housing. An igniter is also provided for igniting the cloud of powder to create a diversionary flash and bang, but at a low enough pressure to avoid injuring nearby people.

  10. Device Connectivity

    PubMed Central

    Walsh, John; Roberts, Ruth; Morris, Richard

    2015-01-01

    Patients with diabetes have to take numerous factors/data into their therapeutic decisions in daily life. Connecting the devices they are using by feeding the data generated into a database/app is supposed to help patients to optimize their glycemic control. As this is not established in practice, the different roadblocks have to be discussed to open the road. That large telecommunication companies are now entering this market might be a big help in pushing this forward. Smartphones offer an ideal platform for connectivity solutions. PMID:25614015

  11. Cooling device

    SciTech Connect

    Teske, L.

    1984-02-21

    A cooling device is claimed for coal dust comprising a housing, a motor-driven conveyor system therein to transport the coal dust over coolable trays in the housing and conveyor-wheel arms of spiral curvature for moving the coal dust from one or more inlets to one or more outlets via a series of communicating passages in the trays over which the conveyor-wheel arms pass under actuation of a hydraulic motor mounted above the housing and driving a vertical shaft, to which the conveyor-wheel arms are attached, extending centrally downwardly through the housing.

  12. OLED devices

    SciTech Connect

    Sapochak, Linda Susan; Burrows, Paul Edward; Bimalchandra, Asanga

    2011-02-22

    An OLED device having an emission layer formed of an ambipolar phosphine oxide host material and a dopant, a hole transport layer in electrical communication with an anode, an electron transport layer in communication with a cathode, wherein the HOMO energy of the hole transport layer is substantially the same as the HOMO energy of the ambipolar host in the emission layer, and the LUMO energy of the electron transport layer is substantially the same as the LUMO energy of the ambipolar host in the emission layer.

  13. Electroexplosive device

    NASA Technical Reports Server (NTRS)

    Menichelli, V. J. (Inventor)

    1978-01-01

    An electroexplosive device is presented which employs a header having contact pins hermetically sealed with glass passing through from a connector end of the header to a cavity filled with a shunt layer of a new nonlinear resistive composition and a heat-sink layer of a new dielectric composition having good thermal conductivity and capacity. The nonlinear resistive layer and the heat-sink layer are prepared from materials by mixing with a low temperature polymerizing resin. The resin is dissolved in a suitable solvent and later evaporated. The resultant solid composite is ground into a powder, press formed into the header and cured (polymerized) at about 250 to 300 F.

  14. Transcriptional map of chromosome region 6q16-->q21.

    PubMed

    Karayianni, E; Magnanini, C; Orphanos, V; Negrini, M; Maniatis, G M; Spathas, D H; Barbanti-Brodano, G; Morelli, C

    1999-01-01

    We present the transcription map of chromosome region 6q16-->q21 by mapping fifteen known genes within this region. Five genes lay in the subregion containing a tumor suppressor gene, eight genes are located in the subregion harboring a senescence gene, and two genes are distal to the latter region. The precise location of the genes was obtained using a previously described translocation and deletion mouse/human hybrid panel. An even more accurate definition was possible for the genes spanning the senescence gene region, since a previously described YAC contig with its restriction map was available. From this transcription map it is possible to derive a large region of synteny with mouse chromosome 10.

  15. Kepler Data Release 25 Notes (Q0-Q17)

    NASA Technical Reports Server (NTRS)

    Mullally, Susan E.; Caldwell, Douglas A.; Barclay, Thomas Stewart; Barentsen, Geert; Clarke, Bruce Donald; Bryson, Stephen T.; Burke, Christopher James; Campbell, Jennifer Roseanna; Catanzarite, Joseph H.; Christiansen, Jessie; hide

    2016-01-01

    These Data Release Notes provide information specific to the current reprocessing and re-export of the Q0-Q17 data. The data products included in this data release include target pixel files, light curve files, FFIs,CBVs, ARP, Background, and Collateral files. This release marks the final processing of the Kepler Mission Data. See Tables 1 and 2 for a list of the reprocessed Kepler cadence data. See Table 3 for a list of the available FFIs. The Long Cadence Data, Short Cadence Data, and FFI data are documented in these data release notes. The ancillary files (i.e., cotrending basis vectors, artifact removal pixels, background, and collateral data) are described in the Archive Manual (Thompson et al., 2016).

  16. Molecular diagnosis of coenzyme Q10 deficiency.

    PubMed

    Yubero, Delia; Montero, Raquel; Armstrong, Judith; Espinós, Carmen; Palau, Francesc; Santos-Ocaña, Carlos; Salviati, Leonardo; Navas, Placido; Artuch, Rafael

    2015-01-01

    Coenzyme Q10 (CoQ) deficiency syndromes comprise a growing number of neurological and extraneurological disorders. Primary-genetic but also secondary CoQ deficiencies have been reported. The biochemical determination of CoQ is a good tool for the rapid identification of CoQ deficiencies but does not allow the selection of candidate genes for molecular diagnosis. Moreover, the metabolic pathway for CoQ synthesis is an intricate and not well-understood process, where a large number of genes are implicated. Thus, only next-generation sequencing techniques (either genetic panels of whole-exome and -genome sequencing) are at present appropriate for a rapid and realistic molecular diagnosis of these syndromes. The potential treatability of CoQ deficiency strongly supports the necessity of a rapid molecular characterization of patients, since primary CoQ deficiencies may respond well to CoQ treatment.

  17. Particle creation from Q-balls

    NASA Astrophysics Data System (ADS)

    Clark, Stephen S.

    2006-11-01

    Non-topological solitons, Q-balls can arise in many particle theories with U(1) global symmetries. As was shown by Cohen et al. [A.G. Cohen, S.R. Coleman, H. Georgi, A. Manohar, The evaporation of Q-balls, Nucl. Phys. B 272 (1986) 301], if the corresponding scalar field couples to massless fermions, large Q-balls are unstable and evaporate, producing a fermion flux proportional to the Q-ball's surface. In this paper we analyse Q-ball instabilities as a function of Q-ball size ans fermion mass. In particular, we construct an exact quantum-mechanical description of the evaporating Q-ball. This new construction provides an alternative method to compute Q-ball's evaporation rates. We shall also find the new expression for the upper bound on evaporation as a function of the produced fermion mass and study the effects of Q ball's size on particle production.

  18. q-integral representations of modified q-Bessel functions and q-Macdonald functions

    NASA Astrophysics Data System (ADS)

    Ol'shanetskii, M. A.; Rogov, V.-B. K.

    1997-08-01

    The q-analogues of modified Bessel functions and Macdonald functions were defined in the previous paper of the authors as general solutions of certain second-order difference equations. Several representations of these functions based on the Jackson integral are presented.

  19. A Q-Modulation Technique for Efficient Inductive Power Transmission

    PubMed Central

    Lee, Byunghun; Yeon, Pyungwoo; Ghovanloo, Maysam

    2015-01-01

    A fully-integrated power management ASIC for efficient inductive power transmission has been presented capable of automatic load transformation using a method, called Q-modulation. Q-modulation is an adaptive scheme that offers load matching against a wide range of loading (RL) and coupling distance (d23) variations in inductive links to maintain high power transfer efficiency (PTE). It is suitable for inductive powering implantable microelectronic devices (IMDs), recharging mobile electronics, and electric vehicles. In Q-modulation, the zero-crossings of the induced current in the receiver (Rx) LC-tank are detected and a low-loss switch chops the Rx LC-tank for part of the power carrier cycle to form a high-Q LC-tank and store the maximum energy, which is then transferred to RL by opening the switch. By adjusting the duty cycle (D), the loaded-Q of the Rx LC-tank can be dynamically modulated to compensate for variations in RL. A Q-modulation power management (QMPM) prototype chip was fabricated in a 0.35-μm standard CMOS process, occupying 4.8 mm2. In a 1.45 W wireless power transfer setup, using a class-E power amplifier (PA) operating at 2 MHz, the QMPM successfully increased the inductive link PTE and the overall power efficiency by 98.5% and 120.7% at d23 = 8 cm, respectively, by compensating for 150 Ω variation in RL at D = 45%. PMID:27087699

  20. 40 CFR Table 1 to Subpart Q of... - General Provisions Applicability to Subpart Q

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Subpart Q 1 Table 1 to Subpart Q of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY.... 63, Subpt. Q, Table 1 Table 1 to Subpart Q of Part 63—General Provisions Applicability to Subpart Q Reference Applies to Subpart Q Comment 63.1 Yes 63.2 Yes 63.3 No 63.4 Yes 63.5 No 63.6 (a), (b), (c), and (j...

  1. Electrochemistry of Q-Graphene

    NASA Astrophysics Data System (ADS)

    Randviir, Edward P.; Brownson, Dale A. C.; Gómez-Mingot, Maria; Kampouris, Dimitrios K.; Iniesta, Jesús; Banks, Craig E.

    2012-09-01

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of <=50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(ii), hexaammine-ruthenium(iii) chloride and hexachloroiridate(iii), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  2. A stationary q-metric

    NASA Astrophysics Data System (ADS)

    Toktarbay, S.; Quevedo, H.

    2014-10-01

    We present a stationary generalization of the static $q-$metric, the simplest generalization of the Schwarzschild solution that contains a quadrupole parameter. It possesses three independent parameters that are related to the mass, quadrupole moment and angular momentum. We investigate the geometric and physical properties of this exact solution of Einstein's vacuum equations, and show that it can be used to describe the exterior gravitational field of rotating, axially symmetric, compact objects.

  3. Electrochemistry of Q-graphene.

    PubMed

    Randviir, Edward P; Brownson, Dale A C; Gómez-Mingot, Maria; Kampouris, Dimitrios K; Iniesta, Jesús; Banks, Craig E

    2012-10-21

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of ≤50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(II), hexaammine-ruthenium(III) chloride and hexachloroiridate(III), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  4. CLOSURE DEVICE

    DOEpatents

    Linzell, S.M.; Dorcy, D.J.

    1958-08-26

    A quick opening type of stuffing box employing two banks of rotatable shoes, each of which has a caraming action that forces a neoprene sealing surface against a pipe or rod where it passes through a wall is presented. A ring having a handle or wrench attached is placed eccentric to and between the two banks of shoes. Head bolts from the shoes fit into slots in this ring, which are so arranged that when the ring is rotated a quarter turn in one direction the shoes are thrust inwardly to cramp the neopnrene about the pipe, malting a tight seal. Moving the ring in the reverse direction moves the shoes outwardly and frees the pipe which then may be readily removed from the stuffing box. This device has particular application as a closure for the end of a coolant tube of a neutronic reactor.

  5. Optoelectronic device

    DOEpatents

    Bonekamp, Jeffrey E.; Boven, Michelle L.; Gaston, Ryan S.

    2014-09-09

    The invention is an optoelectronic device comprising an active portion which converts light to electricity or converts electricity to light, the active portion having a front side for the transmittal of the light and a back side opposite from the front side, at least two electrical leads to the active portion to convey electricity to or from the active portion, an enclosure surrounding the active portion and through which the at least two electrical leads pass wherein the hermetically sealed enclosure comprises at the front side of the active portion a barrier material which allows for transmittal of light, one or more getter materials disposed so as to not impede the transmission of light to or from the active portion, and a contiguous gap pathway to the getter material which pathway is disposed between the active portion and the barrier material.

  6. PLASMA DEVICE

    DOEpatents

    Baker, W.R.

    1961-08-22

    A device is described for establishing and maintaining a high-energy, rotational plasma for use as a fast discharge capacitor. A disc-shaped, current- conducting plasma is formed in an axinl magnetic field and a crossed electric field, thereby creating rotational kinetic enengy in the plasma. Such energy stored in the rotation of the plasma disc is substantial and is convertible tc electrical energy by generator action in an output line electrically coupled to the plasma volume. Means are then provided for discharging the electrical energy into an external circuit coupled to the output line to produce a very large pulse having an extremely rapid rise time in the waveform thereof. (AE C)

  7. Electrophoresis device

    NASA Technical Reports Server (NTRS)

    Rhodes, P. H.; Snyder, R. S. (Inventor)

    1982-01-01

    A device for separating cellular particles of a sample substance into fractionated streams of different cellular species includes a casing having a distribution chamber, a separation chamber, and a collection chamber. The electrode chambers are separated from the separation chamber interior by means of passages such that flow variations and membrane variations around the slotted portion of the electrode chamber do not enduce flow perturbations into the laminar buffer curtain flowing in the separation chamber. The cellular particles of the sample are separated under the influence of the electrical field and the separation chamber into streams of different cellular species. The streams of separated cells enter a partition array in the collection chamber where they are fractionated and collected.

  8. Physical and encoded Q-plates for the generation of switchable vector beams

    NASA Astrophysics Data System (ADS)

    Moreno, Ignacio; Sánchez-López, María. del Mar; Davis, Jeffrey A.; Badham, Katherine; Delaney, Sam W.; Cottrell, Don M.; Hashimoto, Nobuyuki; Tanabe, Ayano; Kurihara, Makoto

    2016-09-01

    In this work we report on our achievements in generating switchable and arbitrary vector beams by means of q-plates. Two kind of q-plates are considered: i) a physical prototype from Citizen Co. and ii) a virtual device that is encoded onto a spatial light modulator (SLM). In both cases experimental and analytical results within the Jones formalism are shown. The performance of a segmented and tunable liquid crystal q-plate prototype is characterized at visible and telecommunications wavelengths, and the generation of first-order vector beams is probed. By using a reflective geometry and tuning the q-plate at half-wave or at quarter-wave retardance, it is shown how the device can operate either as a q-plate with double order. Finally, we show the generation of arbitrary programmable integer and fractional vector beams by encoding a q-plate onto a SLM based system. The system is based on a double-pass configuration that consecutively modulates the vertical and the horizontal polarization components of light using a transmissive LCoS display. Therefore, new and exotic q-plate designs can be analyzed prior to their fabrication.

  9. Absorption band Q model for the Earth

    NASA Technical Reports Server (NTRS)

    Anderson, D. L.; Given, J. W.

    1981-01-01

    Attenuation in solids and liquids, as measured by the quality factor Q, is typically frequency dependent. In seismology, however, Q is usually assumed to be independent of frequency. Body wave, surface wave, and normal mode data are used to place constraints on the frequency dependence of Q in the mantle. Specific features of the absorption band model are: low-Q in the seismic band at both the top and the base of the mantle, low-Q for long-period body waves in the outer core, an inner core Q sub s that increases with period, and low Q sub p/Q sub s at short periods in the middle mantle.

  10. Supersymmetric q-deformed quantum mechanics

    SciTech Connect

    Traikia, M. H.; Mebarki, N.

    2012-06-27

    A supersymmetric q-deformed quantum mechanics is studied in the weak deformation approximation of the Weyl-Heisenberg algebra. The corresponding supersymmetric q-deformed hamiltonians and charges are constructed explicitly.

  11. q-deformed harmonic and Clifford analysis and the q-Hermite and Laguerre polynomials

    NASA Astrophysics Data System (ADS)

    Coulembier, K.; Sommen, F.

    2010-03-01

    We define a q-deformation of the Dirac operator, inspired by the one-dimensional q-derivative. This implies a q-deformation of the partial derivatives. By taking the square of this Dirac operator we find a q-deformation of the Laplace operator. This allows us to construct q-deformed Schrödinger equations in higher dimensions. The equivalence of these Schrödinger equations with those defined on q-Euclidean space in quantum variables is shown. We also define the m-dimensional q-Clifford-Hermite polynomials and show their connection with the q-Laguerre polynomials. These polynomials are orthogonal with respect to an m-dimensional q-integration, which is related to integration on q-Euclidean space. The q-Laguerre polynomials are the eigenvectors of an suq(1|1)-representation.

  12. Localizing chronic Q fever: a challenging query

    PubMed Central

    2013-01-01

    Background Chronic Q fever usually presents as endocarditis or endovascular infection. We investigated whether 18F-FDG PET/CT and echocardiography were able to detect the localization of infection. Also, the utility of the modified Duke criteria was assessed. Methods Fifty-two patients, who had an IgG titre of ≥ 1024 against C. burnetii phase I ≥ 3 months after primary infection or a positive PCR ≥ 1 month after primary infection, were retrospectively included. Data on serology, the results of all imaging studies, possible risk factors for developing proven chronic Q fever and clinical outcome were recorded. Results According to the Dutch consensus on Q fever diagnostics, 18 patients had proven chronic Q fever, 14 probable chronic Q fever, and 20 possible chronic Q fever. Of the patients with proven chronic Q fever, 22% were diagnosed with endocarditis, 17% with an infected vascular prosthesis, and 39% with a mycotic aneurysm. 56% of patients with proven chronic Q fever did not recall an episode of acute Q fever. Ten out of 13 18F-FDG PET/CT-scans in patients with proven chronic Q fever localized the infection. TTE and TEE were helpful in only 6% and 50% of patients, respectively. Conclusions If chronic Q fever is diagnosed, 18F-FDG PET/CT is a helpful imaging technique for localization of vascular infections due to chronic Q fever. Patients with proven chronic Q fever were diagnosed significantly more often with mycotic aneurysms than in previous case series. Definite endocarditis due to chronic Q fever was less frequently diagnosed in the current study. Chronic Q fever often occurs in patients without a known episode of acute Q fever, so clinical suspicion should remain high, especially in endemic regions. PMID:24004470

  13. Two-loop amplitudes for q g →H q and q q ¯ →H g mediated by a nearly massless quark

    NASA Astrophysics Data System (ADS)

    Melnikov, Kirill; Tancredi, Lorenzo; Wever, Christopher

    2017-03-01

    We compute the two-loop QCD corrections to q g →H q and q q ¯ →H g amplitudes mediated by loops of nearly massless quarks. These amplitudes provide the last missing ingredient required to compute the next-to-leading-order QCD corrections to the top-bottom interference contribution to the Higgs boson transverse momentum distribution at hadron colliders.

  14. Clinical and molecular cytogenetic studies in ten patients with hematological malignancies characterized by t(20;21)(q11;q11) resulted from del(20q).

    PubMed

    Wu, Chunxiao; Zhang, Jun; Bai, Shuxiao; Yao, Jianxin; Qiu, Huiying; Xue, Yongquan; Chen, Suning; Wu, Yafang; Shen, Juan; Pan, Jinlan

    2016-10-01

    This study reports 10 patients with hematological malignances with t(20;21)(q11;q11) resulting from del(20q) (for example, der(20)del(20)(q11q13)t(20;21)(q11;q11) and der(21)t(20;21)(q11;q11)) and described their clinical features and the possible prognostic significance of this abnormality. The t(20;21)(q11;q11) was a rare but recurrent abnormality secondary to del(20q) besides i(20q-). The frequency of der(20)del(20)(q11q13)t(20;21)(q11;q11) among our patients with del(20q) was 2.4%. It was considered that the 20q deletion preceded translocation with chromosome 21. This abnormality is often cryptic, occurs predominantly in older men and is observed most often in myelodysplastic syndromes. Patients with this abnormality have an unfavorable prognosis, similar to patients with i(20q-). The molecular consequences of der(20)del(20)(q11q13)t(20;21)(q11;q11) may be different from patients with i(20q-). To the best of our knowledge this is the largest dataset published to date.

  15. Q Methodology, Communication, and the Behavioral Text.

    ERIC Educational Resources Information Center

    McKeown, Bruce

    1990-01-01

    Discusses Q methodology in light of modern philosophy of science and hermeneutics. Outlines and discusses the basic steps of conducting Q-method research. Suggests that Q methodology allows researchers to understand and interpret the subjective text of respondents without confounding them with external categories of theoretical reflection. (RS)

  16. Q-derivatives, coherent states and squeezing

    NASA Technical Reports Server (NTRS)

    Celeghini, E.; Demartino, S.; Desiena, S.; Rasetti, M.; Vitiello, G.

    1994-01-01

    We show that the q-deformation of the Weyl-Heisenberg (q-WH) algebra naturally arises in discretized systems, coherent states, squeezed states and systems with periodic potential on the lattice. We incorporate the q-WH algebra into the theory of (entire) analytical functions, with applications to theta and Bloch functions.

  17. Q Methodology, Communication, and the Behavioral Text.

    ERIC Educational Resources Information Center

    McKeown, Bruce

    1990-01-01

    Discusses Q methodology in light of modern philosophy of science and hermeneutics. Outlines and discusses the basic steps of conducting Q-method research. Suggests that Q methodology allows researchers to understand and interpret the subjective text of respondents without confounding them with external categories of theoretical reflection. (RS)

  18. Intrauterine devices.

    PubMed

    Gromko, L

    1980-01-01

    IUDs were 1st used in Poland in 1909 when Richter introduced a silkworm gut device. Grafenberg's ring, made 1st of silkworm gut and later of gold or silver, was used in Berlin in the 1920s, but dangerous infections were associated with these IUDs. In the early 1960s new biologically inert materials (stainless steel and plastic) were used for the Lippes Loop, the Saf-T-Coil, and the Spiral (associated with a higher expulsion rate). The stainless tell Majzlin Spring was recalled by the FDA because of embedding in the uterine wall. The Dalkon Shield, introduced in the early 1970s, was implicated in midtrimester septic abortions and deaths, and was later withdrawn. Progestasert containing progesterone was 1st used in the mid-1970s, however, side effects included dysmenorrhea, vaso-vagal reaction, and higher ectopic pregnancy rates. Stimulation of the vagus nerve occurring during tenaculum placement can induce symptoms known as the vaso-vagal reaction: bradycardia, hypotension, nausea, pallor, syncope, and cardiac arrest. Moderate symptoms may be relieved by atropine sulfate (.6 mg iv). Baseline pulse and blood pressure must be routinely read before IUD fitting. Sounding the uterus during menstruation and a follow-up visit within 3 months with x-ray if necessary is recommended to rule out perforation. Reported expulsion rates vary from 1 to 24%, mostly among nulliparas. Copper-bearing devices usually require laparotomy for removal. Pregnancy occurs in 1-5% of IUD users. Removal may trigger spontaneous abortion, but the in situ IUD poses more danger. The theoretical efficacy of IUDs is 97-99% (of 100 women correctly using IUDs for 1 year, 1-3 become pregnant). Their disadvantages include increased dysmenorrhea, menstrual cramps, and bleeding. An estimated 5-10% of pregnancies occurring with an IUD in situ are ectopic. Women who use IUDs are several times more likely to develop pelvic inflammatory disease (PID) than nonusers. Recent research substantiates a 4.4 to 9-fold

  19. Status of the 2Q-LEBT facility at ANL.

    SciTech Connect

    Scott, R. H.; Asseev, V. N.; Kulevoy, T. V.; Ostroumov, P. N.; Poklonskaya, E. A.; Sengupta, M.; Vinogradov, N. E.; Physics; ITEP; St. Petersburg Electrochemical Univ.; Northern Illinois Univ.

    2007-07-01

    The concept for a 2 charge state injector for a 'RIA type' accelerator has been presented. Progress toward an operational prototype 2Q-LEBT system at Argonne National Laboratory (ANL) is under way. The existing BIE 100 all permanent magnet ECR has been placed on a high voltage platform capable of a combined >100kV with q/m separation at ground level. Remote control of the devices on the platform has been implemented. Other components of the facility are currently being tested. The components of an achromatic bending system are currently being procured. This paper will present recent work at the facility as well as preliminary development of solid materials using the BIE 100.

  20. Integrated device architectures for electrochromic devices

    DOEpatents

    Frey, Jonathan Mack; Berland, Brian Spencer

    2015-04-21

    This disclosure describes systems and methods for creating monolithically integrated electrochromic devices which may be a flexible electrochromic device. Monolithic integration of thin film electrochromic devices may involve the electrical interconnection of multiple individual electrochromic devices through the creation of specific structures such as conductive pathway or insulating isolation trenches.

  1. Air-Q laryngeal airway for rescue and tracheal intubation.

    PubMed

    Ads, Ayman; Auerbach, Frederic; Ryan, Kelly; El-Ganzouri, Abdel R

    2016-08-01

    We report the successful use of the Air-Q laryngeal airway (Air-Q LA) as a ventilatory device and a conduit for tracheal intubation to rescue the airway in a patient with difficult airway and tracheal stenosis. This is the first case report of the device to secure the airway after two episodes of hypoxemia in the operating room and intensive care unit. Consent for submission of this case report was obtained from our institution's human studies institutional review board given that the patient died a few months after his discharge from the hospital before his personal consent could be obtained and before preparation of this report. All personal identifiers that could lead to his identification have been removed from this report. A 59-year-old man was scheduled for a flexible and rigid bronchoscopy with possible laser excision of tracheal stenosis. He had a history of hypertension, atrial fibrillation, and diabetes. Assessment of airway revealed a thyromental distance of 6.5 cm, Mallampati class II, and body weight of 110 kg. He had hoarseness and audible inspiratory/expiratory stridor with Spo2 90% breathing room air. After induction and muscle relaxation, tracheal intubation and flexible bronchoscopy were achieved without incident. The patient was then extubated and a rigid bronchoscopy was attempted but failed with Spo2 dropping to 92%; rocuronium 60 mg was given, and reintubation was accomplished with a 7.5-mm endotracheal tube. A second rigid bronchoscopy attempt failed, with Spo2 dropping to 63%. Subsequent direct laryngoscopy revealed a bloody hypopharynx. A size 4.5 Air-Q LA was placed successfully and confirmed with capnography, and Spo2 returned to 100%. The airway was suctioned through the Air-Q LA device, and the airway was secured using a fiberoptic bronchoscope to place an endotracheal tube of 7.5-mm internal diameter. The case was canceled because of edema of the upper airway from multiple attempts with rigid bronchoscopy. The patient was transported

  2. High-Q contacted ring microcavities with scatterer-avoiding “wiggler” Bloch wave supermode fields

    SciTech Connect

    Liu, Yangyang Popović, Miloš A.

    2014-05-19

    High-Q ring resonators with contacts to the waveguide core provide a versatile platform for various applications in chip-scale optomechanics, thermo-, and electro-optics. We propose and demonstrate azimuthally periodic contacted ring resonators based on multi-mode Bloch matching that support contacts on both the inner and outer radius edges with small degradation to the optical quality factor (Q). Radiative coupling between degenerate modes of adjacent radial spatial order leads to imaginary frequency (Q) splitting and a scatterer avoiding high-Q “wiggler” supermode field. We experimentally measure Qs up to 258 000 in devices fabricated in a silicon device layer on buried oxide undercladding and up to 139 000 in devices fully suspended in air using an undercut step. Wiggler supermodes are true modes of the microphotonic system that offer additional degrees of freedom in electrical, thermal, and mechanical design.

  3. Physical findings in 21q22 deletion suggest critical region for 21q - phenotype in q22

    SciTech Connect

    Thedoropoulos, D.S.; Cowan, J.M.; Elias, E.R.; Cole, C.

    1995-11-06

    Multiple abnormalities were observed in a newborn infant with a deletion in the long arm of chromosome 21, from band 22q22.1{yields}qter. The phenotype of this infant was similar to that previously described in infants with deletions spanning the long arm of chromosome 21, from the centromere to 21q22. However, as a phenotypically normal child with normal intelligence and with deletion of 21q11.1-21q21.3 has also been identified, this case suggests that the critical region of deletion for the 21q - phenotype lies distal to 21q21, within 21q22.1-22.2. 10 refs., 2 figs.

  4. A girl with 15q overgrowth syndrome and dup(15)(q24q26.3) that included telomeric sequences.

    PubMed

    Gutiérrez-Franco, María de Los Angeles; Madariaga-Campos, María de la Luz; Vásquez-Velásquez, Ana I; Matute, Esmeralda; Guevara-Yáñez, Roberto; Rivera, Horacio

    2010-06-01

    Distal 15q trisomy or tetrasomy is associated with a characteristic phenotype that includes mild to moderate intellectual disability, abnormal behavior, speech impairment, overgrowth, hyperlaxity, long face, prominent nose, puffy cheeks, pointed chin, small ears, and hand anomalies (mainly arachno- and camptodactyly). We present the case of a 13-yr-old girl with the main clinical features of 15q overgrowth syndrome and a 46,XX,dup(15)(q24q26.3)[117]/46,XX[3].ish dup(15)(q24q26.3) (SNPRN+,PML+,subtel++,tel++) de novo karyotype. The findings in this case are consistent with those in the previous distal 15q trisomy cases that presented with overgrowth and mental retardation. Further, the rearranged chromosome had a double set of directly oriented telomeric and subtelomeric sequences.

  5. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2004-11-23

    A laser device includes a target position, an optical component separated a distance J from the target position, and a laser energy source separated a distance H from the optical component, distance H being greater than distance J. A laser source manipulation mechanism exhibits a mechanical resolution of positioning the laser source. The mechanical resolution is less than a spatial resolution of laser energy at the target position as directed through the optical component. A vertical and a lateral index that intersect at an origin can be defined for the optical component. The manipulation mechanism can auto align laser aim through the origin during laser source motion. The laser source manipulation mechanism can include a mechanical index. The mechanical index can include a pivot point for laser source lateral motion and a reference point for laser source vertical motion. The target position can be located within an adverse environment including at least one of a high magnetic field, a vacuum system, a high pressure system, and a hazardous zone. The laser source and an electro-mechanical part of the manipulation mechanism can be located outside the adverse environment. The manipulation mechanism can include a Peaucellier linkage.

  6. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2007-07-10

    A laser device includes a target position, an optical component separated a distance J from the target position, and a laser energy source separated a distance H from the optical component, distance H being greater than distance J. A laser source manipulation mechanism exhibits a mechanical resolution of positioning the laser source. The mechanical resolution is less than a spatial resolution of laser energy at the target position as directed through the optical component. A vertical and a lateral index that intersect at an origin can be defined for the optical component. The manipulation mechanism can auto align laser aim through the origin during laser source motion. The laser source manipulation mechanism can include a mechanical index. The mechanical index can include a pivot point for laser source lateral motion and a reference point for laser source vertical motion. The target position can be located within an adverse environment including at least one of a high magnetic field, a vacuum system, a high pressure system, and a hazardous zone. The laser source and an electro-mechanical part of the manipulation mechanism can be located outside the adverse environment. The manipulation mechanism can include a Peaucellier linkage.

  7. High Q silica microbubble resonators

    NASA Astrophysics Data System (ADS)

    Farnesi, D.; Barucci, A.; Berneschi, S.; Brenci, M.; Cosi, F.; Nunzi Conti, G.; Pelli, S.; Righini, G. C.; Soria, S.

    2012-01-01

    Microbubble resonators (MBRs) combine the unique properties of whispering gallery mode resonators with the intrinsic capability of integrated microfluidics. Here an improved fabrication method of MBRs is presented, based on the heating of a slightly pressurized capillary by a rotating arc discharge. Rotation of the electrodes ensures an homogeneous distribution of the heat all over the capillary surface. The demonstrated MBRs have Q factors up to 107 at 773 nm. Microbubbles were filled with water and aqueous solutions of ethanol in order to test the refractive index sensing capabilities of such resonators, which also show a good temporal stability.

  8. Various endocrine disorders in children with t(13;14)(q10;q10) Robertsonian translocation.

    PubMed

    Choi, Byung Ho; Kim, Uk Hyun; Lee, Kun Soo; Ko, Cheol Woo

    2013-09-01

    45,XY,t(13;14)(q10;q10) karyotype can suggest infertility associated with more or less severe oligospermia in male adults. In addition, 45,XX,t(13;14)(q10;q10) karyotype carries reproductive risks such as miscarriage or infertility in female adults. However, reports on the phenotype of this karyotype in children are very rare. This study was done to observe various phenotypes of this karyotype in children. Between January 2007 and December 2012, children diagnosed with 45,XY,t(13;14)(q10;q10) or 45,XX,t(13;14)(q10;q10) karyotype by chromosome analysis were analyzed retrospectively. Eight children (5 boys and 3 girls) were diagnosed with 45,XY,t(13;14)(q10;q10) or 45,XX,t(13;14)(q10;q10) karyotype. They ranged in age from 5 years and 6 months to 12 years and 4 months. The phenotypes of the study patients consisted of 1 hypogonadotrophic hypogonadism, 1 precocious puberty, 3 early puberty, 2 growth hormone deficiency (GHD) (partial) and 1 idiopathic short stature. As shown here t(13;14)(q10;q10) Robertsonian translocation shows a wide range of phenotypes. It can be said that t(13;14)(q10;q10) Robertsonian translocation shows various phenotypes from GHD to precocious puberty in children. Further large-scale studies are necessary.

  9. Fate of thermal log type Q balls

    SciTech Connect

    Chiba, Takeshi; Kamada, Kohei; Kasuya, Shinta; Yamaguchi, Masahide

    2010-11-15

    We study time evolution of the Q ball in thermal logarithmic potential using lattice simulations. As the temperature decreases due to the cosmic expansion, the thermal logarithmic term in the potential is eventually overcome by a mass term, and we confirm that the Q ball transforms from the thick-wall type to the thin-wall type for a positive coefficient of radiative corrections to the mass term, as recently suggested. Moreover, we find that the Q ball finally ''melts down'' when the Q-ball solution disappears. We also discuss the effects of this phenomenon on the detectability of gravitational waves from the Q-ball formation.

  10. q-entropy for symbolic dynamical systems

    NASA Astrophysics Data System (ADS)

    Zhao, Yun; Pesin, Yakov

    2015-12-01

    For symbolic dynamical systems we use the Carathéodory construction as described in (Pesin 1997 Dimension Theory in Dynamical Systems, ConTemporary Views and Applications (Chicago: University of Chicago Press)) to introduce the notions of q-topological and q-metric entropies. We describe some basic properties of these entropies and in particular, discuss relations between q-metric entropy and local metric entropy. Both q-topological and q-metric entropies are new invariants respectively under homeomorphisms and metric isomorphisms of dynamical systems.

  11. The lagrangian of q- Poincar é gravity

    NASA Astrophysics Data System (ADS)

    Castellani, Leonardo

    1994-05-01

    The gauging of the q- Poincar é algebra of L. Castellani [Differential calculus on ISOq( N), quantum Poincaré algebra and q-gravity, Torino preprint DFTT-70/93, hep-th 9312179] yields a non-commutative generalization of the Einstein-Cartan lagrangian. We prove its invariance under local q-Lorentz rotations and, up to a total derivative, under q-diffeomorphisms. The variations of the fields are given by their q-Lie derivative, in analogy with the q = 1 case. The algebra of q-Lie derivatives is shown to close with field dependent structure functions. The equations of motion are found, generalizing the Einstein equations and the zero-torsion condition.

  12. High Q BPS Monopole Bags are Urchins

    NASA Astrophysics Data System (ADS)

    Evslin, Jarah; Gudnason, Sven Bjarke

    2014-01-01

    It has been known for 30 years that 't Hooft-Polyakov monopoles of charge Q greater than one cannot be spherically symmetric. Five years ago, Bolognesi conjectured that, at some point in their moduli space, BPS monopoles can become approximately spherically symmetric in the high Q limit. In this paper, we determine the sense in which this conjecture is correct. We consider an SU(2) gauge theory with an adjoint scalar field, and numerically find configurations with Q units of magnetic charge and a mass which is roughly linear in Q, for example, in the case Q = 81 we present a configuration whose energy exceeds the BPS bound by about 54%. These approximate solutions are constructed by gluing together Q cones, each of which contains a single unit of magnetic charge. In each cone, the energy is largest in the core, and so a constant energy density surface contains Q peaks and thus resembles a sea urchin.

  13. Generalized q-sampling imaging.

    PubMed

    Yeh, Fang-Cheng; Wedeen, Van Jay; Tseng, Wen-Yih Isaac

    2010-09-01

    Based on the Fourier transform relation between diffusion magnetic resonance (MR) signals and the underlying diffusion displacement, a new relation is derived to estimate the spin distribution function (SDF) directly from diffusion MR signals. This relation leads to an imaging method called generalized q-sampling imaging (GQI), which can obtain the SDF from the shell sampling scheme used in q-ball imaging (QBI) or the grid sampling scheme used in diffusion spectrum imaging (DSI). The accuracy of GQI was evaluated by a simulation study and an in vivo experiment in comparison with QBI and DSI. The simulation results showed that the accuracy of GQI was comparable to that of QBI and DSI. The simulation study of GQI also showed that an anisotropy index, named quantitative anisotropy, was correlated with the volume fraction of the resolved fiber component. The in vivo images of GQI demonstrated that SDF patterns were similar to the ODFs reconstructed by QBI or DSI. The tractography generated from GQI was also similar to those generated from QBI and DSI. In conclusion, the proposed GQI method can be applied to grid or shell sampling schemes and can provide directional and quantitative information about the crossing fibers.

  14. Engineered Carbon Nanotube Materials for High-Q Nanomechanical Resonators

    NASA Technical Reports Server (NTRS)

    Choi, Daniel S.; Hunt, Brian; Bronikowski, Mike; Epp, Larry; Hoenk, Michael; Hoppe, Dan; Kowalczyk, Bob; Wong, Eric; Xu, Jimmy; Adam, Douglas; Young, Rob

    2003-01-01

    This document represents a presentation offered by the Jet Propulsion Laboratory, with assistance from researchers from Brown University and Northrop Grumman. The presentation took place in Seoul, Korea in July 2003 and attempted to demonstrate the fabrication approach regarding the development of high quality factor (high-Q) mechanical oscillators (in the forms of a tunable nanotube resonator and a nanotube array radio frequency [RF] filter) aimed at signal processing and based on carbon nanotubes. The presentation also addressed parallel efforts to develop both in-plane single nanotube resonators as well as vertical array power devices.

  15. Frequency-constant Q, unity and disorder

    SciTech Connect

    Hargreaves, N.D.

    1995-12-31

    In exploration geophysics we obtain information about the earth by observing its response to different types of applied force. The response can cover the full range of possible Q values (where Q, the quality factor, is a measure of energy dissipation), from close to infinity in the case of deep crustal seismic to close to 0 in the case of many electromagnetic methods. When Q is frequency-constant, however, the various types of response have a common scaling behavior and can be described as being self-affine. The wave-equation then takes on a generalised form, changing from the standard wave-equation at Q = {infinity} to the diffusion equation at Q = 0, via lossy, diffusive, propagation at intermediate Q values. Solutions of this wave-diffusion equation at any particular Q value can be converted to an equivalent set of results for any other Q value. In particular it is possible to convert from diffusive to wave propagation by a mapping from Q < {infinity} to Q = {infinity}. In the context of seismic sounding this is equivalent to applying inverse Q-filtering; in a more general context the mapping integrates different geophysical observations by referencing them to the common result at Q = {infinity}. The self-affinity of the observations for frequency-constant Q is an expression of scale invariance in the fundamental physical properties of the medium of propagation, this being the case whether the mechanism of diffusive propagation is scattering of intrinsic attenuation. Scale invariance, or fractal scaling, is a general property of disordered systems; the assumption of frequency-constant Q not only implies a unity between different geophysical observations, but also suggests that it is the disordered nature of the earth`s sub-surface that is the unifying factor.

  16. Maternal uniparental disomy of chromosome 14 in a boy with t(14q14q) associated with a paternal t(13q14q)

    SciTech Connect

    Tomkins, D.J.; Waye, J.S.; Whelan, D.T.

    1994-09-01

    An 11-year-old boy was referred for chromosomal analysis because of precocious development and behavioral problems suggestive of the fragile X syndrome. The cytogenetic fragile X studies were normal, but a routine GTG-banded karyotype revealed an abnormal male karyotype with a Robertsonian translocation between the two chromosome 14`s: 46,XY,t(14q14q). Paternal karyotyping revealed another abnormal karyotype: 46,XY,t(13q14q). A brother had the same karyotype as the father; the mother was deceased. In order to determine if the apparently balanced t(14q14q) in the proband might be the cause of the clinical findings, molecular analysis of the origin of the chromosome 14`s was initiated. Southern blotting and hybridization with D4S13 showed that the proband had two copies of one maternal allele which was shared by his brother. The brother`s second allele corresponded to one of the paternal alleles; the proband had no alleles from the father. Analysis of four other VNTRs demonstrated the probability of paternity to be greater than 99%. Thus, the t(14q14q) was most likely composed of two maternal chromosome 14`s. Further characterization of the t(14q14q) by dinucleotide repeat polymorphic markers is in progress to determine whether it has arisen from maternal isodisomy or heterodisomy. Several cases of uniparental disomy for chromosome 14 have been reported recently. Paternal disomy appears to be associated with more severe congenital anomalies and mental retardation, whereas maternal disomy may be associated with premature puberty and minimal intellectual impairment. The origin of the t(14q14q) in the present case may be related to the paternal translocation, as the segregation of the t(13q14q) in meiosis could lead to sperm that are nullisomic for chromosome 14.

  17. Neuroblastoma in a boy with MCA/MR syndrome, deletion 11q, and duplication 12q

    SciTech Connect

    Koiffmann, C.P.; Vianna-Morgante, A.M.; Wajntal, A.

    1995-07-31

    Deletion 11q23{r_arrow}qter and duplication 12q23{r_arrow}qter are described in a boy with neuroblastoma, multiple congenital anomalies, and mental retardation. The patient has clinical manifestations of 11q deletion and 12q duplication syndromes. The possible involvement of the segment 11q23{r_arrow}24 in the cause of the neuroblastoma is discussed. 18 refs., 2 figs., 1 tab.

  18. Prader-Willi, Angelman, and 15q11-q13 duplication syndromes

    PubMed Central

    2015-01-01

    Three distinct neurodevelopmental disorders arise primarily from deletions or duplications that occur at the 15q11-q13 locus: Prader-Willi syndrome (PWS), Angelman syndrome (AS), and 15q11-q13 duplication syndrome (Dup15q syndrome). Each of these disorders results from the loss of function or over-expression of at least one imprinted gene. Here we discuss the clinical background, genetic etiology, diagnostic strategy, and management for each of these three disorders. PMID:26022164

  19. Medical devices: US medical device regulation.

    PubMed

    Jarow, Jonathan P; Baxley, John H

    2015-03-01

    Medical devices are regulated by the US Food and Drug Administration (FDA) within the Center for Devices and Radiological Health. Center for Devices and Radiological Health is responsible for protecting and promoting the public health by ensuring the safety, effectiveness, and quality of medical devices, ensuring the safety of radiation-emitting products, fostering innovation, and providing the public with accurate, science-based information about the products we oversee, throughout the total product life cycle. The FDA was granted the authority to regulate the manufacturing and marketing of medical devices in 1976. It does not regulate the practice of medicine. Devices are classified based on complexity and level of risk, and "pre-1976" devices were allowed to remain on the market after being classified without FDA review. Post-1976 devices of lower complexity and risk that are substantially equivalent to a marketed "predicate" device may be cleared through the 510(k) premarket notification process. Clinical data are typically not needed for 510(k) clearance. In contrast, higher-risk devices typically require premarket approval. Premarket approval applications must contain data demonstrating reasonable assurance of safety and efficacy, and this information typically includes clinical data. For novel devices that are not high risk, the de novo process allows FDA to simultaneously review and classify new devices. Devices that are not legally marketed are permitted to be used for clinical investigation purposes in the United States under the Investigational Device Exemptions regulation.

  20. RF-MEMS Load Sensors with Enhanced Q-factor and Sensitivity in a Suspended Architecture.

    PubMed

    Melik, Rohat; Unal, Emre; Perkgoz, Nihan Kosku; Puttlitz, Christian; Demir, Hilmi Volkan

    2011-03-01

    In this paper, we present and demonstrate RF-MEMS load sensors designed and fabricated in a suspended architecture that increases their quality-factor (Q-factor), accompanied with an increased resonance frequency shift under load. The suspended architecture is obtained by removing silicon under the sensor. We compare two sensors that consist of 195 μm × 195 μm resonators, where all of the resonator features are of equal dimensions, but one's substrate is partially removed (suspended architecture) and the other's is not (planar architecture). The single suspended device has a resonance of 15.18 GHz with 102.06 Q-factor whereas the single planar device has the resonance at 15.01 GHz and an associated Q-factor of 93.81. For the single planar device, we measured a resonance frequency shift of 430 MHz with 3920 N of applied load, while we achieved a 780 MHz frequency shift in the single suspended device. In the planar triplet configuration (with three devices placed side by side on the same chip, with the two outmost ones serving as the receiver and the transmitter), we observed a 220 MHz frequency shift with 3920 N of applied load while we obtained a 340 MHz frequency shift in the suspended triplet device with 3920 N load applied. Thus, the single planar device exhibited a sensitivity level of 0.1097 MHz/N while the single suspended device led to an improved sensitivity of 0.1990 MHz/N. Similarly, with the planar triplet device having a sensitivity of 0.0561 MHz/N, the suspended triplet device yielded an enhanced sensitivity of 0.0867 MHz/N.

  1. RF-MEMS Load Sensors with Enhanced Q-factor and Sensitivity in a Suspended Architecture

    PubMed Central

    Melik, Rohat; Unal, Emre; Perkgoz, Nihan Kosku; Puttlitz, Christian; Demir, Hilmi Volkan

    2011-01-01

    In this paper, we present and demonstrate RF-MEMS load sensors designed and fabricated in a suspended architecture that increases their quality-factor (Q-factor), accompanied with an increased resonance frequency shift under load. The suspended architecture is obtained by removing silicon under the sensor. We compare two sensors that consist of 195 μm × 195 μm resonators, where all of the resonator features are of equal dimensions, but one’s substrate is partially removed (suspended architecture) and the other’s is not (planar architecture). The single suspended device has a resonance of 15.18 GHz with 102.06 Q-factor whereas the single planar device has the resonance at 15.01 GHz and an associated Q-factor of 93.81. For the single planar device, we measured a resonance frequency shift of 430 MHz with 3920 N of applied load, while we achieved a 780 MHz frequency shift in the single suspended device. In the planar triplet configuration (with three devices placed side by side on the same chip, with the two outmost ones serving as the receiver and the transmitter), we observed a 220 MHz frequency shift with 3920 N of applied load while we obtained a 340 MHz frequency shift in the suspended triplet device with 3920 N load applied. Thus, the single planar device exhibited a sensitivity level of 0.1097 MHz/N while the single suspended device led to an improved sensitivity of 0.1990 MHz/N. Similarly, with the planar triplet device having a sensitivity of 0.0561 MHz/N, the suspended triplet device yielded an enhanced sensitivity of 0.0867 MHz/N. PMID:24944429

  2. Infection risk associated with a closed luer access device.

    PubMed

    Adams, D; Karpanen, T; Worthington, T; Lambert, P; Elliott, T S J

    2006-03-01

    The potential for microbial contamination associated with a recently developed needleless closed luer access device (CLAD) (Q-Syte; Becton Dickinson, Sandy, UT, USA) was evaluated in vitro. Compression seals of 50 multiply activated Q-Syte devices were inoculated with Staphylococcus epidermidis NCTC 9865 in 25% (v/v) human blood and then disinfected with 70% (v/v) isopropyl alcohol followed by flushing with 0.9% (w/v) sterile saline. Forty-eight of 50 (96%) saline flushes passed through devices that had been activated up to a maximum of 70 times remained sterile. A further 25 Q-Syte CLADs that had undergone multiple activations were challenged with prefilled 0.9% (w/v) sterile saline syringes, the external luer tips of which had been inoculated with S. epidermidis NCTC 9865 prior to accessing the devices. None of the devices that had been accessed up to 70 times allowed passage of micro-organisms, despite challenge micro-organisms being detected on both the syringe tip after activation and the compression seals before decontamination. These findings suggest that the Q-Syte CLAD may be activated up to 70 times with no increased risk of microbial contamination within the fluid pathway. The device may also offer protection from the external surface of syringe tips contaminated with micro-organisms.

  3. MultispeQ Beta: a tool for large-scale plant phenotyping connected to the open PhotosynQ network

    SciTech Connect

    Kuhlgert, Sebastian; Austic, Greg; Zegarac, Robert; Osei-Bonsu, Isaac; Hoh, Donghee; Chilvers, Martin I.; Roth, Mitchell G.; Bi, Kevin; TerAvest, Dan; Weebadde, Prabode; Kramer, David M.

    2016-10-26

    Large-scale high-throughput plant phenotyping (sometimes called phenomics) is becoming increasingly important in plant biology and agriculture and is essential to cutting-edge plant breeding and management approaches needed to meet the food and fuel needs for the next century. Currently, the application of these approaches is severely limited by the availability of appropriate instrumentation and by the ability to communicate experimental protocols, results and analyses. To address these issues, we have developed a low-cost, yet sophisticated open-source scientific instrument designed to enable communities of researchers, plant breeders, educators, farmers and citizen scientists to collect high-quality field data on a large scale. The MultispeQ provides measurements in the field or laboratory of both, environmental conditions (light intensity and quality, temperature, humidity, CO2 levels, time and location) and useful plant phenotypes, including photosynthetic parameters—photosystem II quantum yield (ΦII), non-photochemical exciton quenching (NPQ), photosystem II photoinhibition, light-driven proton translocation and thylakoid proton motive force, regulation of the chloroplast ATP synthase and potentially many others—and leaf chlorophyll and other pigments. Plant phenotype data are transmitted from the MultispeQ to mobile devices, laptops or desktop computers together with key metadata that gets saved to the PhotosynQ platform (https://photosynq.org) and provides a suite of web-based tools for sharing, visualization, filtering, dissemination and analyses. We present validation experiments, comparing MultispeQ results with established platforms, and show that it can be usefully deployed in both laboratory and field settings. We present evidence that MultispeQ can be used by communities of researchers to rapidly measure, store and analyse multiple environmental and plant properties, allowing for deeper understanding of the complex

  4. MultispeQ Beta: a tool for large-scale plant phenotyping connected to the open PhotosynQ network

    PubMed Central

    Austic, Greg; Zegarac, Robert; Osei-Bonsu, Isaac; Hoh, Donghee; Chilvers, Martin I.; Roth, Mitchell G.; Bi, Kevin; TerAvest, Dan; Weebadde, Prabode; Kramer, David M.

    2016-01-01

    Large-scale high-throughput plant phenotyping (sometimes called phenomics) is becoming increasingly important in plant biology and agriculture and is essential to cutting-edge plant breeding and management approaches needed to meet the food and fuel needs for the next century. Currently, the application of these approaches is severely limited by the availability of appropriate instrumentation and by the ability to communicate experimental protocols, results and analyses. To address these issues, we have developed a low-cost, yet sophisticated open-source scientific instrument designed to enable communities of researchers, plant breeders, educators, farmers and citizen scientists to collect high-quality field data on a large scale. The MultispeQ provides measurements in the field or laboratory of both, environmental conditions (light intensity and quality, temperature, humidity, CO2 levels, time and location) and useful plant phenotypes, including photosynthetic parameters—photosystem II quantum yield (ΦII), non-photochemical exciton quenching (NPQ), photosystem II photoinhibition, light-driven proton translocation and thylakoid proton motive force, regulation of the chloroplast ATP synthase and potentially many others—and leaf chlorophyll and other pigments. Plant phenotype data are transmitted from the MultispeQ to mobile devices, laptops or desktop computers together with key metadata that gets saved to the PhotosynQ platform (https://photosynq.org) and provides a suite of web-based tools for sharing, visualization, filtering, dissemination and analyses. We present validation experiments, comparing MultispeQ results with established platforms, and show that it can be usefully deployed in both laboratory and field settings. We present evidence that MultispeQ can be used by communities of researchers to rapidly measure, store and analyse multiple environmental and plant properties, allowing for deeper understanding of the complex interactions between plants

  5. MultispeQ Beta: a tool for large-scale plant phenotyping connected to the open PhotosynQ network

    DOE PAGES

    Kuhlgert, Sebastian; Austic, Greg; Zegarac, Robert; ...

    2016-10-26

    Large-scale high-throughput plant phenotyping (sometimes called phenomics) is becoming increasingly important in plant biology and agriculture and is essential to cutting-edge plant breeding and management approaches needed to meet the food and fuel needs for the next century. Currently, the application of these approaches is severely limited by the availability of appropriate instrumentation and by the ability to communicate experimental protocols, results and analyses. To address these issues, we have developed a low-cost, yet sophisticated open-source scientific instrument designed to enable communities of researchers, plant breeders, educators, farmers and citizen scientists to collect high-quality field data on a large scale.more » The MultispeQ provides measurements in the field or laboratory of both, environmental conditions (light intensity and quality, temperature, humidity, CO2 levels, time and location) and useful plant phenotypes, including photosynthetic parameters—photosystem II quantum yield (ΦII), non-photochemical exciton quenching (NPQ), photosystem II photoinhibition, light-driven proton translocation and thylakoid proton motive force, regulation of the chloroplast ATP synthase and potentially many others—and leaf chlorophyll and other pigments. Plant phenotype data are transmitted from the MultispeQ to mobile devices, laptops or desktop computers together with key metadata that gets saved to the PhotosynQ platform (https://photosynq.org) and provides a suite of web-based tools for sharing, visualization, filtering, dissemination and analyses. We present validation experiments, comparing MultispeQ results with established platforms, and show that it can be usefully deployed in both laboratory and field settings. We present evidence that MultispeQ can be used by communities of researchers to rapidly measure, store and analyse multiple environmental and plant properties, allowing for deeper understanding of the complex interactions between

  6. Electromagnetic pulse-induced current measurement device

    NASA Astrophysics Data System (ADS)

    Gandhi, Om P.; Chen, Jin Y.

    1991-08-01

    To develop safety guidelines for exposure to high fields associated with an electromagnetic pulse (EMP), it is necessary to devise techniques that would measure the peak current induced in the human body. The main focus of this project was to design, fabricate, and test a portable, self-contained stand-on device that would measure and hold the peak current and the integrated change Q. The design specifications of the EMP-Induced Current Measurement Device are as follows: rise time of the current pulse, 5 ns; peak current, 20-600 A; charge Q, 0-20 microcoulombs. The device uses a stand-on parallel-plate bilayer sensor and fast high-frequency circuit that are well-shielded against spurious responses to high incident fields. Since the polarity of the incident peak electric field of the EMP may be either positive or negative, the induced peak current can also be positive or negative. Therefore, the device is designed to respond to either of these polarities and measure and hold both the peak current and the integrated charge which are simultaneously displayed on two separate 3-1/2 digit displays. The prototype device has been preliminarily tested with the EMP's generated at the Air Force Weapons Laboratory (ALECS facility) at Kirtland AFB, New Mexico.

  7. 22q11 deletion syndrome: current perspective

    PubMed Central

    Hacıhamdioğlu, Bülent; Hacıhamdioğlu, Duygu; Delil, Kenan

    2015-01-01

    Chromosome 22q11 is characterized by the presence of chromosome-specific low-copy repeats or segmental duplications. This region of the chromosome is very unstable and susceptible to mutations. The misalignment of low-copy repeats during nonallelic homologous recombination leads to the deletion of the 22q11.2 region, which results in 22q11 deletion syndrome (22q11DS). The 22q11.2 deletion is associated with a wide variety of phenotypes. The term 22q11DS is an umbrella term that is used to encompass all 22q11.2 deletion-associated phenotypes. The haploinsufficiency of genes located at 22q11.2 affects the early morphogenesis of the pharyngeal arches, heart, skeleton, and brain. TBX1 is the most important gene for 22q11DS. This syndrome can ultimately affect many organs or systems; therefore, it has a very wide phenotypic spectrum. An increasing amount of information is available related to the pathogenesis, clinical phenotypes, and management of this syndrome in recent years. This review summarizes the current clinical and genetic status related to 22q11DS. PMID:26056486

  8. Q structure of the oceanic crust

    NASA Astrophysics Data System (ADS)

    Wepfer, W. W.; Christensen, N. I.

    1991-08-01

    Compressional wave attenuations and velocities have been measured as a function of confining pressure in ophiolite samples representing a cross-section of the oceanic crust and uppermost mantle. Data are presented for basalts, diabase dikes, gabbros and a suite of serpentinites and peridotites showing a range of serpentization. An ultrasonic pulse-echo spectral ratio technique was used to determine the attenuations to confining pressures of 500 MPa. From this data a Q profile for the oceanic crust and upper mantle is presented. Q is found to moderately increase with depth through the pillow basalts of the upper oceanic crust. The sheeted dike rocks of Layer 2C show an increase in Q with depth due to progressive metamorphism (from greenschist to amphibolite facies). Q drops abruptly from Layer 2C to Layer 3, though it is not clear why the gabbros have such low Q's. The crust-mantle boundary is a Q discontinuity; however, the Q contrast between Layer 3 and the upper mantle could be altered by upper mantle serpentinization, interlayered gabbros and peridotites at the boundary, or serpentinized peridotite diapirs intruding the gabbroic section. Q varies significantly with the percentage of serpentinization in the ultramafic samples, with the largest changes in Q being at the extremes of zero and full serpentinization. Q is sensitive to the overburden pressure for all of the samples.

  9. Clinical applications of coenzyme Q10.

    PubMed

    Garrido-Maraver, Juan; Cordero, Mario D; Oropesa-Avila, Manuel; Vega, Alejandro Fernandez; de la Mata, Mario; Pavon, Ana Delgado; Alcocer-Gomez, Elisabet; Calero, Carmen Perez; Paz, Marina Villanueva; Alanis, Macarena; de Lavera, Isabel; Cotan, David; Sanchez-Alcazar, Jose A

    2014-01-01

    Coenzyme Q10 (CoQ10) or ubiquinone was known for its key role in mitochondrial bioenergetics as electron and proton carrier; later studies demonstrated its presence in other cellular membranes and in blood plasma, and extensively investigated its antioxidant role. These two functions constitute the basis for supporting the clinical indication of CoQ10. Furthermore, recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, ageing-related oxidative stress and carcinogenesis processes, and also a secondary effect of statin treatment. Many neurodegenerative disorders, diabetes, cancer, fibromyalgia, muscular and cardiovascular diseases have been associated with low CoQ10 levels. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral CoQ10 treatment is a frequent mitochondrial energizer and antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

  10. Long Life Nd:YAG Laser Device

    DTIC Science & Technology

    1977-05-01

    lamp approach was derived from the exe- crable lifetime and reliability characteristics of dc-arc lamps. Most of the failure modes of arc lamps are...single-tube device was built based upon a 3CX1500A ceramic triode. The overall power supply efficiency. Including the 208 VAC- HVDC conversion and...reasonable to consider whether appropriate design could reduce P still further. Increasing the number of turns Increases both L and Q, but equation (3

  11. Development and Use of Fluorescent Antibody and qPCR Protocols for the Electrostatic Spore Trap

    USDA-ARS?s Scientific Manuscript database

    Fluorescent antibody (FA) and qPCR protocols were evaluated for the newly developed aerobiological sampler (Ionic Spore Trap), which depends upon electrostatic deposition of particulates onto a 25 mm aluminum disk (stub). This device was originally designed for assessment of captured particulates by...

  12. Antimicrobial therapies for Q fever

    PubMed Central

    Kersh, Gilbert J.

    2015-01-01

    Summary Q fever is caused by the bacterium Coxiella burnetii and has both acute and chronic forms. The acute disease is a febrile illness often with headache and myalgia that can be self-limiting whereas the chronic disease typically presents as endocarditis and can be life threatening. The normal therapy for the acute disease is a two week course of doxycycline, whereas chronic disease requires 18-24 months of doxycycline in combination with hydroxychloroquine. Alternative treatments are used for pregnant women, young children, and those who cannot tolerate doxycycline. Doxycycline resistance is rare but has been reported. Co-trimoxazole is a currently recommended alternative treatment, but quinolones, rifampin, and newer macrolides may also provide some benefit. PMID:24073941

  13. Regional mapping of loci from human chromosome 2q to sheep chromosome 2q

    SciTech Connect

    Ansari, H.A.; Pearce, P.D.; Maher, D.W.; Malcolm, A.A.; Wood, N.J.; Phua, S.H.; Broad, T.E. )

    1994-03-01

    The human chromosome 2q loci, fibronectin 1 (FN1), the [alpha]1 chain of type III collagen (COL3A1), and the [delta] subunit of the muscle acetylcholine receptor (CHRND) have been regionally assigned to sheep chromosome 2q by in situ hybridization. COL3A1 is pericentromeric (2q12-q21), while FN1 and CHRND are in the subterminal region at 2q41-q44 and 2q42-qter, respectively. The mapping of FN1 assigns the sheep synthenic group U11, which contains FN1, villin 1 (VIL1), isocitrate dehydrogenase 1 (IDH1), and [gamma] subunit of the muscle acetylcholine receptor (CHRNG), to sheep chromosome 2q. Inhibin-[alpha] (INHA) is also assigned to sheep chromosome 2q as FN1 and INHA compose sheep linkage group 3. These seven loci are members of a conserved chromosomal segment in human, mouse, and sheep. 23 refs., 2 figs., 1 tab.

  14. Connector device for building integrated photovoltaic device

    DOEpatents

    Keenihan, James R.; Langmaid, Joe A.; Eurich, Gerald K.; Lesniak, Michael J.; Mazor, Michael H.; Cleerman, Robert J.; Gaston, Ryan S.

    2015-11-10

    The present invention is premised upon a connector device and method that can more easily electrically connect a plurality of PV devices or photovoltaic system components and/or locate these devices/components upon a building structure. It also may optionally provide some additional sub-components (e.g. at least one bypass diode and/or an indicator means) and may enhance the serviceability of the device.

  15. Connector device for building integrated photovoltaic device

    DOEpatents

    Keenihan, James R.; Langmaid, Joseph A.; Eurich, Gerald K.; Lesniak, Michael J.; Mazor, Michael H.; Cleereman, Robert J.; Gaston, Ryan S.

    2014-06-03

    The present invention is premised upon a connector device and method that can more easily electrically connect a plurality of PV devices or photovoltaic system components and/or locate these devices/components upon a building structure. It also may optionally provide some additional sub-components (e.g. at least one bypass diode and/or an indicator means) and may enhance the serviceability of the device.

  16. Doubly active Q switching and mode locking of an all-fiber laser.

    PubMed

    Cuadrado-Laborde, Christian; Díez, Antonio; Cruz, Jose L; Andrés, Miguel V

    2009-09-15

    Simultaneous and independent active Q switching and active mode locking of an erbium-doped fiber laser is demonstrated using all-fiber modulation techniques. A magnetostrictive rod attached to the output fiber Bragg grating modulates the Q factor of the Fabry-Perot cavity, whereas active mode locking is achieved by amplitude modulation with a Bragg-grating-based acousto-optic device. Fully modulated Q-switched mode-locked trains of optical pulses were obtained for a wide range of pump powers and repetition rates. For a Q-switched repetition rate of 500 Hz and a pump power of 100 mW, the laser generates trains of 12-14 mode-locked pulses of about 1 ns each, within an envelope of 550 ns, an overall energy of 0.65 microJ, and a peak power higher than 250 W for the central pulses of the train.

  17. Passive Q-switching of a diode-pumped neodymium:YAG laser

    SciTech Connect

    Morris, J.A.

    1991-01-01

    Compact diode-pumped neodymium:YAG lasers are becoming common commercial devices. Such lasers are often Q-switched to enhance peak power or to allow greater harmonic conversion efficiency. Active electrooptic or acoustooptic modulators are usually used to Q-switch YAG lasers. While these techniques work well, they do require expensive and bulky modulators and driving electronics. For some applications a simpler technique, such as passive Q-switching, could replace these active Q-switches. This thesis investigates the suitability of two color center materials as possible saturable absorbers for compact Nd:YAG lasers. The first material, lithium fluoride with F{sub 2}{sup {minus}} defects, has been used previously as a Q-switch for flashlamp-pumped Nd:YAG lasers. The second material, sodium chloride with F{sub 2}{sup +} defects, has not, to the author's knowledge, been used as a saturable absorber in a YAG laser. Lithium fluoride was found to be an excellent Q-switch material for a small diode-pumped YAG laser. The passively Q-switched pulses were comparable to the best results using active Q-switches. The LiF saturable absorber material is compact, inexpensive, and easy to prepare. The only discovered drawback to this material is the observation of a gradual bleaching of the saturable absorption with extended use at high peak powers. This thesis describes the properties and preparation of the LiF Q-switch material. The use of colored sodium chloride as a Q-switch material is also described. This material has the unique property that the amount of saturable loss in a particular crystal direction can be dynamically adjusted through the action of polarized light incident on the crystal.

  18. Compact Q -balls and Q -shells in C PN-type models

    NASA Astrophysics Data System (ADS)

    Klimas, P.; Livramento, L. R.

    2017-07-01

    We show that the C PN model with an odd number of scalar fields and a V -shaped potential possesses some finite energy compact solutions in the form of Q -balls and Q -shells. Such solutions were obtained in 3 +1 dimensions. The Q -balls appear for N =1 and N =3 , whereas the Q -shells are present for higher odd numbers N . We show that the energy of the solutions behaves as E ˜|Q |5 /6 , where Q stands for the Noether charge.

  19. Ectrodactyly and 7q22.1

    SciTech Connect

    Rivera, H.

    1994-10-15

    This succinct `Letter to the Editor` was written in response to a report on a family exhibiting both a t(2;7)(q21.2;q22.1) and split hand/foot anomaly by Genuardi et al. [1993]. Pertinent sections of the article are discussed, with disagreement taken with a lack of mention to work conducted in 1991 by Rivera et al. in assigning the crucial locus to band 7q22 near to the proximal interface. 3 refs.

  20. Electro-optic Q-switch

    NASA Technical Reports Server (NTRS)

    Zou, Yingyin (Inventor); Chen, Qiushui (Inventor); Zhang, Run (Inventor); Jiang, Hua (Inventor)

    2006-01-01

    An electro-optic Q-switch for generating sequence of laser pulses was disclosed. The Q-switch comprises a quadratic electro-optic material and is connected with an electronic unit generating a radio frequency wave with positive and negative pulses alternatively. The Q-switch is controlled by the radio frequency wave in such a way that laser pulse is generated when the radio frequency wave changes its polarity.

  1. High Q Miniature Sapphire Acoustic Resonator

    NASA Technical Reports Server (NTRS)

    Wang, Rabi T.; Tjoelker, R. L.

    2010-01-01

    We have demonstrated high Q measurements in a room temperature Miniature Sapphire Acoustic Resonator (MSAR). Initial measurements of bulk acoustic modes in room temperature sapphire at 39 MHz have demonstrated a Q of 8.8 x 10(exp 6). The long term goal of this work is to integrate such a high Q resonator with small, low noise quartz oscillator electronics, providing a fractional frequency stability better than 1 x 10(exp -14) @ 1s.

  2. RF system calibration for global Q matrix determination.

    PubMed

    Padormo, Francesco; Beqiri, Arian; Malik, Shaihan J; Hajnal, Joseph V

    2016-06-01

    The use of multiple transmission channels (known as Parallel Transmission, or PTx) provides increased control of the MRI signal formation process. This extra flexibility comes at a cost of uncertainty of the power deposited in the patient under examination: the electric fields produced by each transmitter can interfere in such a way to lead to excessively high heating. Although it is not possible to determine local heating, the global Q matrix (which allows the whole-body Specific Absorption Rate (SAR) to be known for any PTx pulse) can be measured in-situ by monitoring the power incident upon and reflected by each transmit element during transmission. Recent observations have shown that measured global Q matrices can be corrupted by losses between the coil array and location of power measurement. In this work we demonstrate that these losses can be accounted for, allowing accurate global Q matrix measurement independent of the location of the power measurement devices. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Medical Device Safety

    MedlinePlus

    ... More Medical Device Recalls Recent Medical Device Safety Communications FDA analyses and recommendations for patients and health ... about ongoing medical device safety issues. FDA Safety Communication Date FDA Warns Of Potentially Contaminated SPS-1 ...

  4. Medical Device Safety

    MedlinePlus

    A medical device is any product used to diagnose, cure, or treat a condition, or to prevent disease. They range ... may need one in a hospital. To use medical devices safely Know how your device works. Keep instructions ...

  5. Infrared criminalistic devices

    NASA Astrophysics Data System (ADS)

    Gibin, Igor S.; Savkov, E. V.; Popov, Pavel G.

    1996-12-01

    We are presenting the devices of near-IR spectral range in this report. The devices may be used in criminalistics, in bank business, in restoration works, etc. the action principle of these devices is describing briefly.

  6. High-frequency nanophotonic devices

    NASA Astrophysics Data System (ADS)

    Bimberg, D.; Fiol, G.; Meuer, C.; Laemmlin, M.; Kuntz, M.

    2007-02-01

    Recent results on GaAs-based high-speed mode-locked quantum dot (QD) lasers and optical amplifiers with an operation wavelength centered at 1290 nm are reviewed and their complex dependence on device and operating parameters is discussed on the basis of experimental data obtained with integrated fiber-based QD device modules. Hybrid and passive mode-locking of QD lasers with repetition frequencies between 5 and 80 GHz, sub-ps pulse widths, ultra-low timing jitter down to 190 fs, high output peak power beyond 1 W and suppression of Q-switching are reported, showing the large potential of this class of devices for O-band optical fiber applications. Results on cw and dynamical characterization of quantum dot semiconductor optical amplifiers are presented. QD amplifiers exhibit a close-to-ideal noise figure of 4 dB and demonstrate multi-wavelength amplification of three CWDM wavelengths simultaneously. Modelling of QD polarization dependence shows that it should be possible to achieve polarization insensitive SOAs using vertically coupled QD stacks. Amplification of ultra-fast 80 GHz optical combs and bit-error-free data signal amplification at 40 Gb/s with QD SOAs show the potential for their application in future 100 Gb Ethernet networks.

  7. A rare case of trisomy 11q23.3-11q25 and trisomy 22q11.1-22q11.21.

    PubMed

    Zou, P-S; Li, H-F; Chen, L-S; Ma, M; Chen, X-H; Xue, D; Cao, D-H

    2016-05-09

    Partial duplication of the long arm of chromosome 11 and the partial trisomy of 22q are uncommon karyotypic abnormalities. Here, we report the case of a 6-year-old girl who showed partial trisomy of 11q and 22q, as a result of a maternal balanced reciprocal translocation (11;22), and exhibited dysmorphic features, severe intellectual disability, brain malformations, and speech delay related to this unique chromosomal abnormality. Array comparative genomic hybridization (array CGH) revealed a gain in copy number on the long arm of chromosome 11, spanning at least 18.22 Mb. Additionally, there was a gain in copy number on the long arm of chromosome 22, spanning at least 3.46 Mb. FISH analysis using a chromosome 11 short arm telomere probe (11p14.2), a chromosome 11 long arm telomere probe (11q24.3), and a chromosome 22 long arm telomere probe (22q13.33) confirmed the origin of the marker chromosome. It has been confirmed by the State Key Laboratory of Medical Genetics of China that this is the first reported instance of the karyotype 47,XX, +der(22)t(11;22)(q23.3;q11.1)mat in the world. Our study reports an additional case that can be used to further characterize and delineate the clinical ramifications of partial trisomy of 11q and 22q.

  8. Biochemical Assessment of Coenzyme Q10 Deficiency.

    PubMed

    Rodríguez-Aguilera, Juan Carlos; Cortés, Ana Belén; Fernández-Ayala, Daniel J M; Navas, Plácido

    2017-03-05

    Coenzyme Q10 (CoQ10) deficiency syndrome includes clinically heterogeneous mitochondrial diseases that show a variety of severe and debilitating symptoms. A multiprotein complex encoded by nuclear genes carries out CoQ10 biosynthesis. Mutations in any of these genes are responsible for the primary CoQ10 deficiency, but there are also different conditions that induce secondary CoQ10 deficiency including mitochondrial DNA (mtDNA) depletion and mutations in genes involved in the fatty acid β-oxidation pathway. The diagnosis of CoQ10 deficiencies is determined by the decrease of its content in skeletal muscle and/or dermal skin fibroblasts. Dietary CoQ10 supplementation is the only available treatment for these deficiencies that require a rapid and distinct diagnosis. Here we review methods for determining CoQ10 content by HPLC separation and identification using alternative approaches including electrochemical detection and mass spectrometry. Also, we review procedures to determine the CoQ10 biosynthesis rate using labeled precursors.

  9. Coenzyme Q as an antiadipogenic factor.

    PubMed

    Bour, Sandy; Carmona, Maria-Carmen; Galinier, Anne; Caspar-Bauguil, Sylvie; Van Gaal, Luc; Staels, Bart; Pénicaud, Luc; Casteilla, Louis

    2011-02-01

    Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice. We sought to determine (i) whether this deficit exists in all species and its relevance in human obesity and (ii) to what extent CoQ could be involved in adipocyte differentiation. Here we identified in rodents as well as in humans a specific very strong nonlinear negative correlation between CoQ content in subcutaneous adipose tissue and obesity indexes. This striking correlation reveals a threshold value similar in both species. This relative deficit in CoQ content in adipose tissue rapidly took place during the time course of high-fat-diet-induced obesity in mice. Adipocyte differentiation was assessed in vitro using the preadipocyte 3T3-F442A cell line. When CoQ synthesis was inhibited by a pharmacological approach using chlorobenzoic acid, this strongly triggered adipose differentiation. In contrast, adipogenesis was strongly inhibited when a long-term increase in CoQ content was obtained by overexpressing human 4-hydroxy benzoate acid polyprenyltransferase gene. Altogether, these data suggest that a strict level of CoQ remains essential for adipocyte differentiation, and its impairment is associated with obesity.

  10. Biochemical Assessment of Coenzyme Q10 Deficiency

    PubMed Central

    Rodríguez-Aguilera, Juan Carlos; Cortés, Ana Belén; Fernández-Ayala, Daniel J. M.; Navas, Plácido

    2017-01-01

    Coenzyme Q10 (CoQ10) deficiency syndrome includes clinically heterogeneous mitochondrial diseases that show a variety of severe and debilitating symptoms. A multiprotein complex encoded by nuclear genes carries out CoQ10 biosynthesis. Mutations in any of these genes are responsible for the primary CoQ10 deficiency, but there are also different conditions that induce secondary CoQ10 deficiency including mitochondrial DNA (mtDNA) depletion and mutations in genes involved in the fatty acid β-oxidation pathway. The diagnosis of CoQ10 deficiencies is determined by the decrease of its content in skeletal muscle and/or dermal skin fibroblasts. Dietary CoQ10 supplementation is the only available treatment for these deficiencies that require a rapid and distinct diagnosis. Here we review methods for determining CoQ10 content by HPLC separation and identification using alternative approaches including electrochemical detection and mass spectrometry. Also, we review procedures to determine the CoQ10 biosynthesis rate using labeled precursors. PMID:28273876

  11. CONTROL LIMITER DEVICE

    DOEpatents

    DeShong, J.A.

    1960-03-01

    A control-limiting device for monltoring a control system is described. The system comprises a conditionsensing device, a condition-varying device exerting a control over the condition, and a control means to actuate the condition-varying device. A control-limiting device integrates the total movement or other change of the condition-varying device over any interval of time during a continuum of overlapping periods of time, and if the tothl movement or change of the condition-varying device exceeds a preset value, the control- limiting device will switch the control of the operated apparatus from automatic to manual control.

  12. Quasi quantum group covariant q-oscillators

    NASA Astrophysics Data System (ADS)

    Schomerus, Volker

    1993-07-01

    If q is a pth rooty of unit there exists a quasi-co-associative truncated quantum group algebra U qT(sl 2) whose indecomposable representations ar the physical representations of U q(sl 2), whose co-product yields the truncated tensor product of physical representations of U q(sl 2), and whose R-matrix satisfies quasi Yang-Baxter equations. These truncated quantum group algebras are examples of weak quasi quantum group algebras [2]. For primitive pth roots q, q = e 2 πi/ p, we consider a two-dimensional q-oscillator which admits U qT(sl 2) as a symmetry algebra. Its wave function lie in a space FqT of "functions on the truncated quantum plane", i.e. of polynomials in noncommuting complex coordinate functions za, on which multiplication operators Za and the elements of U qT(sl 2) can act. This illustrates the concept of quasi quantum planes [1]. Due to the truncation, the Hilbert space of states is finite dimensional. The subspaces FR(n) of monomials in za of nth degree vanish for n⩾ p - 1, and FT(n) carries the (2 J+1)-dimensional irreducible representation of UqT( sl2) if n = 2J, J = 0, {1}/{2},…, {1}/{2}(p-2) . Partial derivatives ∂a are introduced. We find a ∗-operation on the algebra of multiplication operators, Zi and derivatives ∂b such that the adjoints Z a∗ act as differentiation on the truncated quantum plane. Multiplication operators Za ("creation operators") and their adjoints ("annihilation operators") obey q {-1}/{2}- commutation relations. The ∗-operation is used to determine a positive definite scalar product on the truncated quantum plane FqT. Some natural candidates of hamiltonians for the q-oscillators are determined.

  13. P/Q-type calcium channel modulators

    PubMed Central

    Nimmrich, V; Gross, G

    2012-01-01

    P/Q-type calcium channels are high-voltage-gated calcium channels contributing to vesicle release at synaptic terminals. A number of neurological diseases have been attributed to malfunctioning of P/Q channels, including ataxia, migraine and Alzheimer's disease. To date, only two specific P/Q-type blockers are known: both are peptides deriving from the spider venom of Agelenopsis aperta, ω-agatoxins. Other peptidic calcium channel blockers with activity at P/Q channels are available, albeit with less selectivity. A number of low molecular weight compounds modulate P/Q-type currents with different characteristics, and some exhibit a peculiar bidirectional pattern of modulation. Interestingly, there are a number of therapeutics in clinical use, which also show P/Q channel activity. Because selectivity as well as the exact mode of action is different between all P/Q-type channel modulators, the interpretation of clinical and experimental data is complicated and needs a comprehensive understanding of their target profile. The situation is further complicated by the fact that information on potency varies vastly in the literature, which may be the result of different experimental systems, conditions or the splice variants of the P/Q channel. This review attempts to provide a comprehensive overview of the compounds available that affect the P/Q-type channel and should help with the interpretation of results of in vitro experiments and animal models. It also aims to explain some clinical observations by implementing current knowledge about P/Q channel modulation of therapeutically used non-selective drugs. Chances and challenges of the development of P/Q channel-selective molecules are discussed. PMID:22670568

  14. /q-exponential, Weibull, and /q-Weibull distributions: an empirical analysis

    NASA Astrophysics Data System (ADS)

    Picoli, S.; Mendes, R. S.; Malacarne, L. C.

    2003-06-01

    In a comparative study, the q-exponential and Weibull distributions are employed to investigate frequency distributions of basketball baskets, cyclone victims, brand-name drugs by retail sales, and highway length. In order to analyze the intermediate cases, a distribution, the q-Weibull one, which interpolates the q-exponential and Weibull ones, is introduced. It is verified that the basketball baskets distribution is well described by a q-exponential, whereas the cyclone victims and brand-name drugs by retail sales ones are better adjusted by a Weibull distribution. On the other hand, for highway length the q-exponential and Weibull distributions do not give satisfactory adjustment, being necessary to employ the q-Weibull distribution. Furthermore, the introduction of this interpolating distribution gives an illumination from the point of view of the stretched exponential against inverse power law ( q-exponential with q>1) controversy.

  15. Interstitial deletion of 6q21-q23 associated with split hand

    SciTech Connect

    Tsukahara, Masato; Yoneda, Junko; Azuma, Reiko

    1997-03-31

    We report on a 7-month-old boy with interstitial deletion of 6q21-q23 and split-hand defect. He died at 7 months. This is the fifth patient with distal limb anomaly associated with a rearrangement of 6q21 region, and supports previous suggestions that there may be candidate gene(s) for distal limb development in the 6q21 region. 10 refs., 3 figs., 1 tab.

  16. Prader-Willi, Angelman, and 15q11-q13 Duplication Syndromes.

    PubMed

    Kalsner, Louisa; Chamberlain, Stormy J

    2015-06-01

    Three distinct neurodevelopmental disorders arise primarily from deletions or duplications that occur at the 15q11-q13 locus: Prader-Willi syndrome, Angelman syndrome, and 15q11-q13 duplication syndrome. Each of these disorders results from the loss of function or overexpression of at least 1 imprinted gene. This article discusses the clinical background, genetic cause, diagnostic strategy, and management of each of these 3 disorders.

  17. De novo interstitial tandem duplication of chromosome 4(q21-q28)

    SciTech Connect

    Navarro, E.G.; Ramon, F.J.H.; Jimenez, R.D.

    1996-03-29

    We describe a girl with a previously unreported de novo duplication of chromosome 4q involving segment q21-q28. Clinical manifestations included growth and psychomotor retardation, facial asymmetry, hypotelorism, epicanthic folds, mongoloid slant of palpebral fissures, apparently low-set auricles, high nasal bridge, long philtrum, small mouth, short neck, low-set thumbs, and bilateral club foot. This phenotype is compared with that of previously reported cases of duplication 4q. 12 refs., 3 figs., 1 tab.

  18. Biological validation of coenzyme Q redox state by HPLC-EC measurement: relationship between coenzyme Q redox state and coenzyme Q content in rat tissues.

    PubMed

    Galinier, A; Carrière, A; Fernandez, Y; Bessac, A M; Caspar-Bauguil, S; Periquet, B; Comtat, M; Thouvenot, J P; Casteilla, L

    2004-12-03

    The properties of coenzymes Q (CoQ9 and CoQ10) are closely linked to their redox state (CoQox/total CoQ) x 100. In this work, CoQ redox state was biologically validated by high performance liquid chromatography-electrochemical measurement after modulation of mitochondrial electron flow of cultured cells by molecules increasing (rotenone, carbonyl cyanide chlorophenylhydrazone) or decreasing (antimycin) CoQ oxidation. The tissue specificity of CoQ redox state and content were investigated in control and hypoxic rats. In control rats, there was a strong negative linear regression between tissular CoQ redox state and CoQ content. Hypoxia increased CoQ9 redox state and decreased CoQ9 content in a negative linear relationship in the different tissues, except the heart and lung. This result demonstrates that, under conditions of mitochondrial impairment, CoQ redox control is tissue-specific.

  19. Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p.

    PubMed Central

    Petersen, I.; Langreck, H.; Wolf, G.; Schwendel, A.; Psille, R.; Vogt, P.; Reichel, M. B.; Ried, T.; Dietel, M.

    1997-01-01

    The genetic mechanisms that define the malignant behaviour of small-cell lung cancer (SCLC) are poorly understood. We performed comparative genomic hybridization (CGH) on 22 autoptic SCLCs to screen the tumour genome for genomic imbalances. DNA loss of chromosome 3p was a basic alteration that occurred in all tumours. Additionally, deletions were observed on chromosome 10q in 94% of tumours and on chromosomes 4q, 5q, 13q and 17p in 86% of tumours. DNA loss was confirmed by loss of heterozygosity (LOH) analysis for chromosomes 3p, 5q and 10q. Simultaneous mutations of these six most abundant genetic changes were found in 12 cases. One single tumour carried at least five deletions. DNA under-representations were observed less frequently on chromosome 15q (55%) and chromosome 16q (45%). The prevalent imbalances were clearly indicated by the superposition of the 22 tumours to a CGH superkaryogram. In our view, the high incidence of chromosomal loss is an indication that SCLC is defined by a pattern of deletions and that the inactivation of multiple growth-inhibitory pathways contributes in particular to the aggressive phenotype of that type of tumour. Images Figure 1 Figure 3 Figure 4 PMID:9000602

  20. Understanding Insight in the Context of Q

    ERIC Educational Resources Information Center

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  1. Understanding Insight in the Context of Q

    ERIC Educational Resources Information Center

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  2. Q Fever Chronic Osteomyelitis in Two Children.

    PubMed

    Costa, Beatriz; Morais, Andreia; Santos, Ana Sofia; Tavares, Delfin; Seves, Graça; Gouveia, Catarina

    2015-11-01

    We report 2 cases of chronic Q fever osteomyelitis in 10- and 5-year-old girls who presented with distal right femoral and left parasternal granulomatous osteomyelitis, respectively. Both were treated with ciprofloxacin and rifampin with good response. Q fever osteomyelitis is a challenging diagnosis in children, and the choice of antimicrobial treatment is difficult because of limited available data.

  3. Q-Technique and Graphics Research.

    ERIC Educational Resources Information Center

    Kahle, Roger R.

    Because Q-technique is as appropriate for use with visual and design items as for use with words, it is not stymied by the topics one is likely to encounter in graphics research. In particular Q-technique is suitable for studying the so-called "congeniality" of typography, for various copytesting usages, and for multivariate graphics research. The…

  4. The Q2 mitochondrial haplogroup in Oceania.

    PubMed

    Corser, Chris A; McLenachan, Patricia A; Pierson, Melanie J; Harrison, G L Abby; Penny, David

    2012-01-01

    Many details surrounding the origins of the peoples of Oceania remain to be resolved, and as a step towards this we report seven new complete mitochondrial genomes from the Q2a haplogroup, from Papua New Guinea, Fiji and Kiribati. This brings the total to eleven Q2 genomes now available. The Q haplogroup (that includes Q2) is an old and diverse lineage in Near Oceania, and is reasonably common; within our sample set of 430, 97 are of the Q haplogroup. However, only 8 are Q2, and we report 7 here. The tree with all complete Q genomes is proven to be minimal. The dating estimate for the origin of Q2 (around 35 Kya) reinforces the understanding that humans have been in Near Oceania for tens of thousands of years; nevertheless the Polynesian maternal haplogroups remain distinctive. A major focus now, with regard to Polynesian ancestry, is to address the differences and timing of the 'Melanesian' contribution to the maternal and paternal lineages as people moved further and further into Remote Oceania. Input from other fields such as anthropology, history and linguistics is required for a better understanding and interpretation of the genetic data.

  5. The Q2 Mitochondrial Haplogroup in Oceania

    PubMed Central

    Corser, Chris A.; McLenachan, Patricia A.; Pierson, Melanie J.; Harrison, G. L. Abby; Penny, David

    2012-01-01

    Many details surrounding the origins of the peoples of Oceania remain to be resolved, and as a step towards this we report seven new complete mitochondrial genomes from the Q2a haplogroup, from Papua New Guinea, Fiji and Kiribati. This brings the total to eleven Q2 genomes now available. The Q haplogroup (that includes Q2) is an old and diverse lineage in Near Oceania, and is reasonably common; within our sample set of 430, 97 are of the Q haplogroup. However, only 8 are Q2, and we report 7 here. The tree with all complete Q genomes is proven to be minimal. The dating estimate for the origin of Q2 (around 35 Kya) reinforces the understanding that humans have been in Near Oceania for tens of thousands of years; nevertheless the Polynesian maternal haplogroups remain distinctive. A major focus now, with regard to Polynesian ancestry, is to address the differences and timing of the ‘Melanesian’ contribution to the maternal and paternal lineages as people moved further and further into Remote Oceania. Input from other fields such as anthropology, history and linguistics is required for a better understanding and interpretation of the genetic data. PMID:23284859

  6. Stability properties of Q-stars

    NASA Astrophysics Data System (ADS)

    Becerril, R.; Bernal, A.; Guzmán, F. S.; Nucamendi, U.

    2007-12-01

    We present the evolution of Q-star configurations using numerical methods. We solve the full Einstein-Klein-Gordon system of equations and show that: Q-stars can be stable and unstable. The unstable branch is two fold: configurations with negative binding energy that collapse and form black holes, and others with positive binding energy that explode and release the scalar field.

  7. Q-Technique and Graphics Research.

    ERIC Educational Resources Information Center

    Kahle, Roger R.

    Because Q-technique is as appropriate for use with visual and design items as for use with words, it is not stymied by the topics one is likely to encounter in graphics research. In particular Q-technique is suitable for studying the so-called "congeniality" of typography, for various copytesting usages, and for multivariate graphics research. The…

  8. Information entrophy via Glauber's Q-representation

    NASA Technical Reports Server (NTRS)

    Keitel, C. H.; Wodkiewicz, K.

    1993-01-01

    We present a convenient way to evaluate the information entropy of a quantum mechanical state via the Glauber Q-representation. As an example we discuss the information entropy of a thermally relaxing squeezed state in terms of its Q-representation and show the validity of the corresponding entropic uncertainty- and Araki-Lieb inequalities.

  9. Phase Slips in Topological Superconductor Wire Devices

    NASA Astrophysics Data System (ADS)

    Goldberg, Samuel; Bergman, Doron; Pekker, David; Refael, Gil

    2012-02-01

    We make a detailed study of phase slips in topological superconducting wires and devices based on topological wires. We begin by investigating a device composed of a topological superconducting wire connected to a non-topological wire (T-S). In the T-segment only slips of the phase by multiples of 4π are allowed, while in the S-segment slips by 2π are also allowed. We show that near the interface, 2π phase slips are also allowed and we comment on the consequences of such phase slips for the Aharonov-Casher effect. We also consider an implementation of a q-bit consisting of a T-S-T device, where the quantum information is stored in the parity of the two topological segments via the four Majorana modes. We show that the central S-segment of this type of device can support 2π phase-slips which result in the decoherence of the q-bit.

  10. Microwave Reentrant Cavities for Quantum Devices

    NASA Astrophysics Data System (ADS)

    Carvalho, Natalia C.; Bourhill, Jeremy; Creedon, Daniel; Goryachev, Maxim; Galliou, Serge; Tobar, Michael

    A microwave reentrant cavity is a device able to provide a very sensitive high-Q microwave mode. Its design can be highly advantageous for electromechanical devices and quantum measurements. In this sense, a tuneable device based on a narrow-gap superconducting reentrant cavity is under development. The resonant frequency is able to be fine-tuned over a range larger than 500 MHz at 10 mK with an electrical Q-factor of 105. Such a cavity could possibly accommodate a transmon qubit to control and manipulate its quantum state. We are also working on the investigation of bulk acoustic wave (BAW) resonators in microwave reentrant cavities. BAW resonators offer a promising way to process quantum information through the coupling between microwaves and acoustic phonons. Thus, we are developing a device able to excite phonons through non-linearities and the piezoelectricity of the plano-convex quartz crystal. We will detail our experiments that work towards cooling gram scale phonon resonances to the quantum ground state. Funded by ARC Grant No. CE110001013 (Australia) and National Counsel of Technological and Scientific Development (Brazil).

  11. Q and you: The application of Q methodology in recreation research

    Treesearch

    Whitney. Ward

    2010-01-01

    Researchers have used various qualitative and quantitative methods to deal with subjectivity in studying people's recreation experiences. Q methodology has been the most effective approach for analyzing both qualitative and quantitative aspects of experience, including attitudes or perceptions. The method is composed of two main components--Q sorting and Q factor...

  12. Some identities of the q-Laguerre polynomials on q-Umbral calculus

    NASA Astrophysics Data System (ADS)

    Dere, Rahime

    2017-07-01

    Some interesting identities of Sheffer polynomials was given by Roman [11], [12]. In this paper, we study a q-analogue of Laguerre polynomials which are also q-Sheffer polynomials. Furthermore, we give some new properties and formulas of these q-Laguerre polynomials of higher order by using the theory of the umbral algebra and umbral calculus.

  13. 77 FR 65254 - Amendment of Area Navigation Routes Q-42 and Q-480; PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... amendment. SUMMARY: This action amends the legal descriptions of area navigation (RNAV) routes Q-42 and Q... sounding waypoint this will enhance safety within the National Airspace System and does not change the... of the BEETS waypoint in Q-480. Since this action involves only editorial changes to the legal...

  14. Q Model for the Pacific Northwest

    SciTech Connect

    Hearn, Thomas; Phillips, William S.

    2012-07-24

    USArray seismic data can be used to generate high resolution attenuation (1/Q) models using regional wave amplitudes. Our Q models have been produced for purposes of explosion monitoring (discrimination and yield estimation), for which we focus on small signals at local to regional distances (to 2000 km). We present Q models for regional Lg, which is sensitive to crustal properties averaged over depth. The frequency range of the study is 0.5-16 Hz. Details of Q models may have limited effect over the short distances of interest to hazard work; however, maps may be useful for regionalizing high versus low Q areas. This study has been submitted to a PAGEOPH special issue on monitoring seismology.

  15. The geographical distribution of Q fever

    PubMed Central

    Kaplan, Martin M.; Bertagna, P.

    1955-01-01

    The results of a WHO-assisted survey of the distribution of Q fever in 32 countries and an analysis of reports published to date indicate that Q fever exists in 51 countries on five continents. Q-fever infection was most often reported in man and the domestic ruminants, such as cattle, sheep, and goats. The disease was found to exist in most countries where investigations were carried out. Notable exceptions were Ireland, the Netherlands, New Zealand, Poland, and the Scandinavian countries. With the exception of Poland, where the results were inconclusive, all these countries import relatively few domestic ruminants—the most important animal reservoirs of human Q-fever infection. It seems, therefore, that the traffic of infected ruminants may be one of the most important, if not the most important, means for the geographical spread of Q fever. The importance, if any, of ticks associated with such traffic needs to be defined. PMID:13284560

  16. Laser with optically driven Q-switch

    NASA Technical Reports Server (NTRS)

    Hemmati, Hamid (Inventor)

    1995-01-01

    An optically driven interactive Q-switch, i.e., a Q-switch that responds to a short pulse of light, for example, from external light-emitting diodes (LED's) or diode lasers, is provided for producing an output laser pulse from electronic energy stored in a laser medium. Q-switching is thus achieved on demand by electrically pulsing the light source to produce a pulse of light directed onto a Q-switch medium in the laser cavity. Electronic control of the light pulse from the external source will thus provide not only efficient Q-switching frequency but also independent control of output laser pulse width with a fast rise time for each output laser pulse.

  17. Laser with optically driven Q-switch

    NASA Technical Reports Server (NTRS)

    Hemmati, Hamid (Inventor)

    1993-01-01

    An optically driven interactive Q-switch, i.e., a Q-switch that responds to a short pulse of light, for example, from external light-emitting diodes (LEDs) or diode lasers, is provided for producing an output laser pulse from electronic energy stored in a laser medium. Q-switching is thus achieved on demand by electrically pulsing the light source to produce a pulse of light directed onto a Q-switch medium in the laser cavity. Electronic control of the light pulse from the external source will thus provide not only efficient Q-switching frequency but also independent control of output laser pulse width with a fast rise time for each output laser pulse.

  18. Seismic Q of the lunar upper mantle

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Koyama, J.

    1982-01-01

    Shallow moonquake data are used to determine the frequency dependence of Q values for both compressional and shear waves in the upper mantle of the moon at frequencies between 3 and 8 Hz. The seismic P wave Q is estimated to be at least 4000 and is nearly independent of frequency or decreases slightly with increasing frequency, while the S wave Q increases from at least 4000 at 3 Hz to at least 7000 at 8 Hz. The rate of increase of Q(S) is approximately proportional to the 0.7 + or - 0.1 power of the frequency above 5 Hz. With the absence of other dissipation mechanisms, compressional heat loss may be a dominant factor in the lunar interior. Uncertainty remains, however, in the absolute values of Q's owing to the largely unknown detailed structure of the lunar upper mantle.

  19. The geographical distribution of Q fever.

    PubMed

    KAPLAN, M M; BERTAGNA, P

    1955-01-01

    The results of a WHO-assisted survey of the distribution of Q fever in 32 countries and an analysis of reports published to date indicate that Q fever exists in 51 countries on five continents. Q-fever infection was most often reported in man and the domestic ruminants, such as cattle, sheep, and goats.The disease was found to exist in most countries where investigations were carried out. Notable exceptions were Ireland, the Netherlands, New Zealand, Poland, and the Scandinavian countries. With the exception of Poland, where the results were inconclusive, all these countries import relatively few domestic ruminants-the most important animal reservoirs of human Q-fever infection. It seems, therefore, that the traffic of infected ruminants may be one of the most important, if not the most important, means for the geographical spread of Q fever. The importance, if any, of ticks associated with such traffic needs to be defined.

  20. Seismic Q of the lunar upper mantle

    NASA Astrophysics Data System (ADS)

    Nakamura, Y.; Koyama, J.

    1982-06-01

    Shallow moonquake data are used to determine the frequency dependence of Q values for both compressional and shear waves in the upper mantle of the moon at frequencies between 3 and 8 Hz. The seismic P wave Q is estimated to be at least 4000 and is nearly independent of frequency or decreases slightly with increasing frequency, while the S wave Q increases from at least 4000 at 3 Hz to at least 7000 at 8 Hz. The rate of increase of Q(S) is approximately proportional to the 0.7 + or - 0.1 power of the frequency above 5 Hz. With the absence of other dissipation mechanisms, compressional heat loss may be a dominant factor in the lunar interior. Uncertainty remains, however, in the absolute values of Q's owing to the largely unknown detailed structure of the lunar upper mantle.

  1. Implantable CMOS Biomedical Devices

    PubMed Central

    Ohta, Jun; Tokuda, Takashi; Sasagawa, Kiyotaka; Noda, Toshihiko

    2009-01-01

    The results of recent research on our implantable CMOS biomedical devices are reviewed. Topics include retinal prosthesis devices and deep-brain implantation devices for small animals. Fundamental device structures and characteristics as well as in vivo experiments are presented. PMID:22291554

  2. Coenzyme Q10 and male infertility.

    PubMed

    Balercia, G; Mancini, A; Paggi, F; Tiano, L; Pontecorvi, A; Boscaro, M; Lenzi, A; Littarru, G P

    2009-07-01

    We had previously demonstrated that Coenzyme Q10 [(CoQ10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility). Alterations of CoQ10 content were also shown in conditions associated with male infertility, such as asthenozoospermia and varicocele (VAR). The physiological role of this molecule was further clarified by inquiring into its variations in concentrations induced by different medical or surgical procedures used in male infertility treatment. We therefore evaluated CoQ10 concentration and distribution between seminal plasma and spermatozoa in VAR, before and after surgical treatment, and in infertile patients after recombinant human FSH therapy. The effect of CoQ10 on sperm motility and function had been addressed only through some in vitro experiments. In two distinct studies conducted by our group, 22 and 60 patients affected by idiopathic asthenozoospermia were enrolled, respectively. CoQ10 and its reduced form, ubiquinol, increased significantly both in seminal plasma and sperm cells after treatment, as well as spermatozoa motility. A weak linear dependence among the relative variations, at baseline and after treatment, of seminal plasma or intracellular CoQ10, ubiquinol levels and kinetic parameters was found in the treated group. Patients with lower baseline value of motility and CoQ10 levels had a statistically significant higher probability to be responders to the treatment. In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia.

  3. High-Q AlN Contour Mode Resonators with Unattached, Voltage-Actuated Electrodes

    NASA Astrophysics Data System (ADS)

    Schneider, Robert Anthony

    High-Q narrowband filters at ultra-high frequencies hold promise for reducing noise and suppressing interferers in wireless transceivers, yet research efforts confront a daunting challenge. So far, no existing resonator technology can provide the simultaneous high-Q, high electromechanical coupling ( k2eff), frequency tunability, low motional resistance (Rx), stopband rejection, self-switchability, frequency accuracy, and power handling desired to select individual channels or small portions of a band over a wide RF range. Indeed, each technology provides only a subset of the desired properties. Recently introduced "capacitive-piezoelectric" resonators, i.e., piezoelectric resonators with non-contacting transduction electrodes, known for achieving very good Q's, have recently emerged (in the early 2010's) as a contender among existing technologies to address the needs of RF narrowband selection. Several reports of such devices, made from aluminum nitride (AlN), have demonstrated improved Q's over attached electrode counterparts at frequencies up to 1.2 GHz, albeit with reduced transduction efficiency due to the added capacitive gaps. Fabrication challenges, while still allowing for a glimpse of the promise of this technology, have, until now, hindered attempts at more complex devices than just simple resonators with improved Q's. This thesis project demonstrates several key improvements to capacitive-piezo technology, which, taken together, further bolster its case for deployment for frequency control applications. (Abstract shortened by ProQuest.).

  4. CMOS compatible high-Q photonic crystal nanocavity fabricated with photolithography on silicon photonic platform.

    PubMed

    Ooka, Yuta; Tetsumoto, Tomohiro; Fushimi, Akihiro; Yoshiki, Wataru; Tanabe, Takasumi

    2015-06-18

    Progress on the fabrication of ultrahigh-Q photonic-crystal nanocavities (PhC-NCs) has revealed the prospect for new applications including silicon Raman lasers that require a strong confinement of light. Among various PhC-NCs, the highest Q has been recorded with silicon. On the other hand, microcavity is one of the basic building blocks in silicon photonics. However, the fusion between PhC-NCs and silicon photonics has yet to be exploited, since PhC-NCs are usually fabricated with electron-beam lithography and require an air-bridge structure. Here we show that a 2D-PhC-NC fabricated with deep-UV photolithography on a silica-clad silicon-on-insulator (SOI) structure will exhibit a high-Q of 2.2 × 10(5) with a mode-volume of ~ 1.7(λ/n)(3). This is the highest Q demonstrated with photolithography. We also show that this device exhibits an efficient thermal diffusion and enables high-speed switching. The demonstration of the photolithographic fabrication of high-Q silica-clad PhC-NCs will open possibility for mass-manufacturing and boost the fusion between silicon photonics and CMOS devices.

  5. CMOS compatible high-Q photonic crystal nanocavity fabricated with photolithography on silicon photonic platform

    PubMed Central

    Ooka, Yuta; Tetsumoto, Tomohiro; Fushimi, Akihiro; Yoshiki, Wataru; Tanabe, Takasumi

    2015-01-01

    Progress on the fabrication of ultrahigh-Q photonic-crystal nanocavities (PhC-NCs) has revealed the prospect for new applications including silicon Raman lasers that require a strong confinement of light. Among various PhC-NCs, the highest Q has been recorded with silicon. On the other hand, microcavity is one of the basic building blocks in silicon photonics. However, the fusion between PhC-NCs and silicon photonics has yet to be exploited, since PhC-NCs are usually fabricated with electron-beam lithography and require an air-bridge structure. Here we show that a 2D-PhC-NC fabricated with deep-UV photolithography on a silica-clad silicon-on-insulator (SOI) structure will exhibit a high-Q of 2.2 × 105 with a mode-volume of ~1.7(λ/n)3. This is the highest Q demonstrated with photolithography. We also show that this device exhibits an efficient thermal diffusion and enables high-speed switching. The demonstration of the photolithographic fabrication of high-Q silica-clad PhC-NCs will open possibility for mass-manufacturing and boost the fusion between silicon photonics and CMOS devices. PMID:26086849

  6. Observation of the fundamental Nyquist noise limit in an ultra-high Q-factor cryogenic bulk acoustic wave cavity

    SciTech Connect

    Goryachev, Maxim Ivanov, Eugene N.; Tobar, Michael E.; Kann, Frank van; Galliou, Serge

    2014-10-13

    Thermal Nyquist noise fluctuations of high-Q bulk acoustic wave cavities have been observed at cryogenic temperatures with a DC superconducting quantum interference device amplifier. High Q modes with bandwidths of few tens of milliHz produce thermal fluctuations with a signal-to-noise ratio of up to 23 dB. The estimated effective temperature from the Nyquist noise is in good agreement with the physical temperature of the device, confirming the validity of the equivalent circuit model and the non-existence of any excess resonator self-noise. The measurements also confirm that the quality factor remains extremely high (Q > 10{sup 8} at low order overtones) for very weak (thermal) system motion at low temperatures, when compared to values measured with relatively strong external excitation. This result represents an enabling step towards operating such a high-Q acoustic device at the standard quantum limit.

  7. Improvement of vibration energy harvesters mechanical Q-factor through high density proof mass integration

    NASA Astrophysics Data System (ADS)

    Dompierre, A.; Fréchette, L. G.

    2016-11-01

    This paper reports on improvement of the mechanical Q-factor of resonant energy harvesters at ambient pressure via the use of tungsten proof masses by evaluating the impact of the mass size and density on the squeeze film damping. To this end, a simplified model is first proposed to evaluate cantilever beams deflection and the resulting fluid pressure build up between the mass and a near surface. The model, which accounts for simultaneous transverse and rotational motion of very long tip masses as well as for 2D fluid flow in the gap, is used to extract a scaling law for the device fluidic Q-factor Qf. This law states that Qf can be improved by either increasing the linear mass density of the tip mass or by reducing the side lengths compared to the gap height. The first approach is validated experimentally by adding a tungsten proof mass on a silicon based device and observing an improvement of the Q-factor by 103%, going from 430 to 871, while the resonance frequency drops from 457 to 127 Hz. In terms of fluidic Q-factor, this represents an increase from 562 to 1673. These results successfully demonstrate the benefits of integrating a tungsten mass to reduce the fluid losses while potentially reducing the device footprint.

  8. Evaluation of three portable suction devices.

    PubMed

    Simon, E J; Davidson, J A; Boom, S J

    1993-09-01

    Three portable suction devices were evaluated and compared with a wall-mounted vacuum driven suction unit. The Repro-med Res-Q-Vac, the Dräger Sujector 2000 and the Laerdal suction unit were assessed by measuring the time taken to aspirate 140 ml of mock gastric contents. The respective times for each device, expressed as mean and (range) were 7.39 (4.3-10.4), 8.6 (7.8-9.4) and 11.4 (9.4-12.6) s. These compare favourable with the Ohmeda suction unit (7.27 (6.2-8.9)). Each type of device has advantages and disadvantages when factors such as size, power supply and portability are considered, and each will be the most suitable for a particular situation.

  9. Fluid sampling device

    NASA Technical Reports Server (NTRS)

    Studenick, D. K. (Inventor)

    1977-01-01

    An inlet leak is described for sampling gases, more specifically, for selectively sampling multiple fluids. This fluid sampling device includes a support frame. A plurality of fluid inlet devices extend through the support frame and each of the fluid inlet devices include a longitudinal aperture. An opening device that is responsive to a control signal selectively opens the aperture to allow fluid passage. A closing device that is responsive to another control signal selectively closes the aperture for terminating further fluid flow.

  10. De novo interstitial deletion q16.2q21 on chromosome 6

    SciTech Connect

    Villa, A.; Urioste, M.; Luisa, M.

    1995-01-30

    A de novo interstitial deletion of 6q16.2q21 was observed in a 23-month-old boy with mental and psychomotor delay, obese appearance, minor craniofacial anomalies, and brain anomalies. We compare clinical manifestations of this patient with those observed in previously reported cases with similar 6q interstitial deletions. It is interesting to note the clinical similarities between some patients with interstitial deletions of 6q16 or q21 bands and patients with Prader-Willi syndrome (PWS) and it may help to keep in mind cytogenetic studies of patients with some PWS findings. 24 refs., 3 figs., 2 tabs.

  11. Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13.

    PubMed

    Chamberlain, Stormy J; Lalande, Marc

    2010-07-01

    Human chromosome 15q11-q13 is subject to regulation by genomic imprinting, an epigenetic process by which genes are expressed in a parent-of-origin specific manner. Three neurodevelopmental disorders, Prader-Willi syndrome, Angelman syndrome, and 15q duplication syndrome, result from aberrant expression of imprinted genes in this region. Here, we review the current literature pertaining to mouse models and recently identified patients with atypical deletions, which shed light on the epigenetic regulation of the chromosome 15q11-q13 subregion and the genes that are responsible for the phenotypic outcomes of these disorders.

  12. q-Painlevé VI Equation Arising from q-UC Hierarchy

    NASA Astrophysics Data System (ADS)

    Tsuda, Teruhisa; Masuda, Tetsu

    2006-03-01

    We study the q-difference analogue of the sixth Painlevé equation ( q- P VI) by means of tau functions associated with the affine Weyl group of type D 5. We prove that a solution of q- P VI coincides with a self-similar solution of the q-UC hierarchy. As a consequence, we obtain in particular algebraic solutions of q- P VI in terms of the universal character which is a generalization of the Schur polynomial attached to a pair of partitions.

  13. Coupling, Q-Factor, and Integration Aspects of Microsphere Applications

    NASA Technical Reports Server (NTRS)

    Ilchenko, V. S.; Yao, X. S.; Maleki, L.

    2000-01-01

    With suggested applications varying from microlaser and cavity QED through optical locking of diode lasers to modulators and sensors, high-Q silica microspheres with whispering-gallery (WG) modes so far remain the subject of tabletop feasibility demonstrations. Despite the uniquely high quality-factor and submillimeter dimensions suitable for tight packaging, this novel type of high-finesse cavity still has to be adapted to fiber- and integrated-optic hardware. In the visible and near infrared-band experiments (633-850nm) measuring the ringdown time tau of free oscillations, Q = (0.6 to 0.8 ) x 10(exp 10) has been obtained in silica spheres of diameter -800 microns (corresponding tau = 3 to 4 microseconds). It was proved that under normal laboratory conditions, quality-factor is subject to deterioration within several-minute scale down to (2 ... 3 ) x 10(exp 9). The responsible mechanism was identified as adsorption of a monolayer of atmospheric water, so that preservation of the ultimate Q requires manipulation in dry environment, or fast packaging into sealed devices. Larger Q can be expected closer to minimum of attenuation in fused silica alpha = 0.2 dB/km; Q greater than or equal to 1 x 10(exp 11) at lambda=1.55 microns, with corresponding energy storage time tau approx. 0.1ms. Experiments are currently underway to determine whether this high Q can be realized experimentally. The evident difficulty is that OH-related optical absorption has its peaks located near the reported minimum of attenuation in silica. We can also mention here that some of proposed fiber materials, yet not ready for fiber drawing, have been predicted to have smaller attenuation than fused silica and may be suitable for microsphere fabrication (sodium-magnesium silicate glass, alpha = 0.06dB/km). WG modes possess very small radiative loss (it does not prevent Q-10(exp 20) and more) and therefore are electromagnetically isolated and cannot be excited by free-space beams. If no modification

  14. Comparison of Chest Compressions Metrics Measured Using the Laerdal Skill Reporter and Q-CPR: A Simulation Study.

    PubMed

    Davey, Paul; Whatman, Chris; Dicker, Bridget

    2015-10-01

    There has been an increased emphasis on the quality of chest compressions as a part of the cardiopulmonary resuscitation (CPR) bundle of care for recent times. During CPR training, chest compression quality parameters can be measured directly from sensors within a manikin or from external devices placed on the manikin chest that use accelerometer-based technology. The aim of this study was to compare external chest compression data from the manikin-based Laerdal Skill Reporter (LSR) and the accelerometer-based Q-CPR technology, incorporated into the Philips MRx defibrillator, during CPR on a single Resusci Anne Simulator manikin. Each paramedic (n = 15) performed 2 sessions of 2 minutes of chest compressions, with a 2-minute rest period in between sessions. Both over-the-head and from-the-side positions were used on a single manikin. The quality of chest compressions were concurrently measured using both LSR and Philips MRx Q-CPR accelerometer with audiovisual feedback disabled. There was no significant difference in the measurement of the number of chest compressions performed in 2 minutes, the compression rate, total number of compressions of adequate depth, or the number of compressions exhibiting leaning between the LSR and the Phillips Q-CPR devices. There was a significant difference in measurement of compression depth (P < 0.0001) and duty cycle (P < 0.0001) with the MRx Q-CPR accelerometer demonstrating both lower compression depth and duty cycle compared with LSR. There was no significant difference in most chest compression quality metrics measured between the LSR and the Phillips Q-CPR devices when measured on a manikin. However, there were significant differences in the measurement of duty cycle and also the depth of compressions between the 2 devices with the Phillips Q-CPR device measuring lower depth of compression and duty cycle compared with the LSR device.

  15. SLE and C1q: A quantitative ELISA for determining C1q levels in serum

    PubMed Central

    Dillon, Skyler P.; D’Souza, Anil; Kurien, Biji T.; Scofield, R. Hal

    2010-01-01

    C1q is of interest in SLE research due to deficiencies in its activity being associated with the disease. Current published protocols for measuring C1q vary greatly in their results and ease of reproducibility. Due to this, average C1q concentrations have been reported between 56 and 276 µg/ml in non-SLE serum. We present an improved method for quantifying C1q concentrations that employs a sandwich ELISA. This method has improved precision, cost efficiency, up-scaling, reproducibility, and uses significantly lesser volumes of serum sample when compared to RID and other methods for quantifying C1q. We report an average concentration of 113±40 µg/ml for C1q in non-SLE serum. The assay designed here will be useful in the high-throughput measurement of serum C1q in SLE cases. PMID:19370710

  16. Squeezing the fundamental temperature fluctuations of a high-Q microresonator

    NASA Astrophysics Data System (ADS)

    Sun, Xuan; Luo, Rui; Zhang, Xi-Cheng; Lin, Qiang

    2017-02-01

    Temperature fluctuations of an optical resonator underlie a fundamental limit of its cavity stability. Here we show that the fundamental temperature fluctuations of a high-Q microresonator can be suppressed remarkably by pure optical means without cooling the device temperature. An optical wave launched into the cavity is able to produce strong photothermal backaction which dramatically suppresses the spectral intensity of temperature fluctuations and squeezes its overall level by orders of magnitude. The proposed photothermal temperature squeezing is expected to significantly improve the stability of optical resonances, with potentially profound impact on broad applications of high-Q cavities in sensing, metrology, and nonlinear and quantum optics.

  17. Dispersion engineering of high-Q silicon microresonators via thermal oxidation

    SciTech Connect

    Jiang, Wei C.; Zhang, Jidong; Usechak, Nicholas G.; Lin, Qiang

    2014-07-21

    We propose and demonstrate a convenient and sensitive technique for precise engineering of group-velocity dispersion in high-Q silicon microresonators. By accurately controlling the surface-oxidation thickness of silicon microdisk resonators, we are able to precisely manage the zero-dispersion wavelength, while simultaneously further improving the high optical quality of our devices, with the optical Q close to a million. The demonstrated dispersion management allows us to achieve parametric generation with precisely engineerable emission wavelengths, which shows great potential for application in integrated silicon nonlinear and quantum photonics.

  18. Extremely high Q-factor mechanical modes in quartz bulk acoustic wave resonators at millikelvin temperature

    SciTech Connect

    Goryachev, M.; Creedon, D. L.; Ivanov, E. N.; Tobar, M. E.; Galliou, S.; Bourquin, R.

    2014-12-04

    We demonstrate that Bulk Acoustic Wave (BAW) quartz resonator cooled down to millikelvin temperatures are excellent building blocks for hybrid quantum systems with extremely long coherence times. Two overtones of the longitudinal mode at frequencies of 15.6 and 65.4 MHz demonstrate a maximum f.Q product of 7.8×10{sup 16} Hz. With this result, the Q-factor in such devices near the quantum ground state can be four orders of magnitude better than previously attained in other mechanical systems. Tested quartz resonators possess the ultra low acoustic losses crucial for electromagnetic cooling to the phonon ground state.

  19. Gravitational waves from Q-ball formation

    SciTech Connect

    Chiba, Takeshi; Kamada, Kohei; Yamaguchi, Masahide

    2010-04-15

    We study the detectability of the gravitational waves (GWs) from the Q-ball formation associated with the Affleck-Dine (AD) mechanism, taking into account both the dilution effects due to Q-ball domination and to finite temperature. The AD mechanism predicts the formation of nontopological solitons, Q-balls, from which GWs are generated. Q-balls with large conserved charge Q can produce a large amount of GWs. On the other hand, the decay rate of such Q-balls is so small that they may dominate the energy density of the Universe, which implies that GWs are significantly diluted and that their frequencies are redshifted during the Q-ball dominated era. Thus, the detectability of the GWs associated with the formation of Q-balls is determined by these two competing effects. We find that there is a finite but small parameter region where such GWs may be detected by future detectors such as DECIGO or BBO, only in the case when the thermal logarithmic potential dominates the potential of the AD field. Otherwise GWs from Q-balls would not be detectable even by these futuristic detectors: {Omega}{sub GW}{sup 0}<10{sup -21}. Unfortunately, for such parameter region the present baryon asymmetry of the Universe can hardly be explained unless one fine-tunes A-terms in the potential. However the detection of such a GW background may give us an information about the early Universe, for example, it may suggest that the flat directions with B-L=0 are favored.

  20. Adult case of partial trisomy 9q

    PubMed Central

    2010-01-01

    Background Complete and partial trisomy 9 is the fourth most common chromosomal disorder. It is also associated with various congenital characteristics affecting the cranio-facial, skeletal, central nervous, gastrointestinal, cardiac and renal systems. Very few cases have been reported in adults. Partial trisomy 9q is also associated with short stature, poor growth and growth hormone deficiency. This is the first reported case of an extensive endocrinology investigation of short stature in trisomy 9q and the outcome of growth hormone treatment. Case Presentation The case involves a 23-year-old female of pure partial trisomy 9q. The case involves a 23-year old female with pure partial trisomy 9q involving a duplication of 9q22.1 to q32, de novo, confirmed by genetic studies using fluorescene in situ hybridization (FISH) method. The diagnosis was at 6 years of age. She did not demonstrate all the congenital morphologies identified with trisomy 9q disorders especially in relation to multi-organ morphologies. There is also a degree of associated intellectual impairment. At prepuberty, she was referred for poor growth and was diagnosed with partial growth hormone deficiency. She responded very well to treatment with growth hormone and is currently living an independent life with some support. Conclusions Trisomy 9q is associated with short stature and failure to thrive. Growth hormone deficiency should be identified in cases of trisomy 9q and treatment offered. This is the first reported case of response to growth hormone replacement in partial trisomy 9. PMID:20158889

  1. Invertebrate Models for Coenzyme Q10 Deficiency

    PubMed Central

    Fernández-Ayala, Daniel J.M.; Jiménez-Gancedo, Sandra; Guerra, Ignacio; Navas, Plácido

    2014-01-01

    The human syndrome of coenzyme Q (CoQ) deficiency is a heterogeneous mitochondrial disease characterized by a diminution of CoQ content in cells and tissues that affects all the electron transport processes CoQ is responsible for, like the electron transference in mitochondria for respiration and ATP production and the antioxidant capacity that it exerts in membranes and lipoproteins. Supplementation with external CoQ is the main attempt to address these pathologies, but quite variable results have been obtained ranging from little response to a dramatic recovery. Here, we present the importance of modeling human CoQ deficiencies in animal models to understand the genetics and the pathology of this disease, although the election of an organism is crucial and can sometimes be controversial. Bacteria and yeast harboring mutations that lead to CoQ deficiency are unable to grow if they have to respire but develop without any problems on media with fermentable carbon sources. The complete lack of CoQ in mammals causes embryonic lethality, whereas other mutations produce tissue-specific diseases as in humans. However, working with transgenic mammals is time and cost intensive, with no assurance of obtaining results. Caenorhabditis elegans and Drosophila melanogaster have been used for years as organisms to study embryonic development, biogenesis, degenerative pathologies, and aging because of the genetic facilities and the speed of working with these animal models. In this review, we summarize several attempts to model reliable human CoQ deficiencies in invertebrates, focusing on mutant phenotypes pretty similar to those observed in human patients. PMID:25126050

  2. Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.

    PubMed Central

    Schwendel, A.; Richard, F.; Langreck, H.; Kaufmann, O.; Lage, H.; Winzer, K. J.; Petersen, I.; Dietel, M.

    1998-01-01

    Comparative genomic hybridization was applied to map DNA gains and losses in 39 invasive ductal breast carcinomas. Frequent abnormalities included gains on chromosomal regions 1q, 8q, 11q12-13, 16p, 19, 20q and X as well as frequent losses on 1p, 5q, 6q, 9p, 11q, 13q and 16q. Furthermore, frequent losses on 4q (20 cases) and 21q (14 cases) were found for the first time in this tumour type. High copy number amplifications were observed at 8q12-24, 11q11-13 and 20q13-ter. Highly differentiated tumours were associated with gains on 1q and 11q12-13 along with losses on 1p21-22, 4q, 13q, 11q21-ter. Undifferentiated breast carcinomas were characterized by additional DNA imbalances, i.e. deletions of 5q13-23, all of chromosome 9, the centromeric part of chromosome 13 including band 13q14 and the overrepresentation of chromosome X. We speculate that these changes are associated with tumour progression of invasive ductal breast cancer. Images Figure 2 Figure 3 PMID:9743305

  3. [Distribution of ubiquinones (coenzyme Q) in Gram negative bacillae].

    PubMed

    Denis, F A; D'Oultremont, P A; Debacq, J J; Cherel, J M; Brisou, J

    1975-01-01

    The coenzyme Q system was examined on 55 strains of Gram negative aerobic or facultatively anaerobic rods. No bacteria contain Co-Q7 nor Co-Q10. Ubiquinone Q8 predominates in Flavobacterium and in Enterobacteriaceae; Q9 was the only homolog found in the Pseudomonas, and predominates in the Acinetobacter.

  4. The Q sort theory and technique.

    PubMed

    Nyatanga, L

    1989-10-01

    This paper is based on the author's experience of using the Q sort technique with BA Social Sciences (BASS) students, and the community psychiatric nursing (CPN, ENB No 811 course). The paper focuses on two main issues: 1. The theoretical assumptions underpinning the Q Sort technique. Carl Rogers' self theory and some of the values of humanistic psychology are summarised. 2. The actual technique procedure and meaning of results are highlighted. As the Q Sort technique is potentially useful in a variety of sittings some of which are listed in this paper, the emphasis has deliberately been placed in understanding the theoretical underpinning and the operationalisation (sensitive interpretation) of the theory to practice.

  5. The Q field, a variable quaternion basis

    SciTech Connect

    Efremov, A.P.

    1986-06-01

    The author introduces the concept of the Q field as a 2 x 2 matrix representation of the variable basis of vectors satisfying the rule of multiplication of quaternion imaginary numbers and as an element of the group of transformations of the basis preserving the invariance of this multiplication rule. The rule for projecting such matrices on a given direction is determined with the help of the characteristic functions of the matrices-vectors of the Q field. The differential structure of Q fields is studied and the theory developed is illustrated by an example of a model-topological classification of particles according to the magnitude of their spin.

  6. Primitive ideals of C q [ SL(3)

    NASA Astrophysics Data System (ADS)

    Hodges, Timothy J.; Levasseur, Thierry

    1993-10-01

    The primitive ideals of the Hopf algebra C q [ SL(3)] are classified. In particular it is shown that the orbits in Prim C q [ SL(3)] under the action of the representation group H ≅ C *× C * are parameterized naturally by W×W, where W is the associated Weyl group. It is shown that there is a natural one-to-one correspondence between primitive ideals of C q [ SL(3)] and symplectic leaves of the associated Poisson algebraic group SL(3, C).

  7. Inflation Driven by q-de Sitter

    NASA Astrophysics Data System (ADS)

    Setare, M. R.; Momeni, D.; Kamali, V.; Myrzakulov, R.

    2016-02-01

    We propose a generalised de Sitter scale factor for the cosmology of early and late time universe, including single scalar field is called as inflaton. This form of scale factor has a free parameter q is called as nonextensivity parameter. When q = 1, the scale factor is de Sitter. This scale factor is an intermediate form between power-law and de Sitter. We study cosmology of such families. We show that both kinds of dark components, dark energy and dark matter simultaneously are described by this family of solutions. As a motivated idea, we investigate inflation in the framework of q-de Sitter. We consider three types of scenarios for inflation. In a single inflation scenario, we observe that, inflation ended without any specific ending inflation ϕ e n d , the spectral index and the associated running of the spectral index are n s - 1 ˜ -2 𝜖, α s ≡ 0. To end the inflation: we should have q={3}/{4}. We deduce that the inflation ends when the evolution of the scale factor is a( t) = e 3/4( t). With this scale factor there is no need to specify ϕ e n d . As an alternative to have inflation with ending point, We will study q-inflation model in the context of warm inflation. We propose two forms of damping term Γ. In the first case when Γ = Γ0, we show the scale invariant spectrum, (Harrison-Zeldovich spectrum, i.e. n s = 1) may be approximately presented by (q={9}/{10}, ~N=70). Also there is a range of values of R and n s which is compatible with the BICEP2 data where q={9}/{10}. In case Γ = Γ1 V( ϕ), it is observed that small values of a number of e-folds are assured for small values of q parameter. Also in this case, the scale-invariant spectrum may be represented by (q,N) = ({9}/{10},70). For q={9}/{10} a range of values of R and n s is compatible with the BICEP2 data. Consequently, the proposal of q-de Sitter is consistent with observational data. We observe that the non-extensivity parameter q plays a significant role in inflationary scenario.

  8. Rotating boson stars and Q-balls

    SciTech Connect

    Kleihaus, Burkhard; Kunz, Jutta; List, Meike

    2005-09-15

    We consider axially symmetric, rotating boson stars. Their flat-space limits represent spinning Q-balls. We discuss their properties and determine their domain of existence. Q-balls and boson stars are stationary solutions and exist only in a limited frequency range. The coupling to gravity gives rise to a spiral-like frequency dependence of the boson stars. We address the flat-space limit and the limit of strong gravitational coupling. For comparison we also determine the properties of spherically symmetric Q-balls and boson stars.

  9. Using Q Methodology in Quality Improvement Projects.

    PubMed

    Tiernon, Paige; Hensel, Desiree; Roy-Ehri, Leah

    Q methodology consists of a philosophical framework and procedures to identify subjective viewpoints that may not be well understood, but its use in nursing is still quite limited. We describe how Q methodology can be used in quality improvement projects to better understand local viewpoints that act as facilitators or barriers to the implementation of evidence-based practice. We describe the use of Q methodology to identify nurses' attitudes about the provision of skin-to-skin care after cesarean birth. Copyright © 2017 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

  10. The q-Laguerre matrix polynomials.

    PubMed

    Salem, Ahmed

    2016-01-01

    The Laguerre polynomials have been extended to Laguerre matrix polynomials by means of studying certain second-order matrix differential equation. In this paper, certain second-order matrix q-difference equation is investigated and solved. Its solution gives a generalized of the q-Laguerre polynomials in matrix variable. Four generating functions of this matrix polynomials are investigated. Two slightly different explicit forms are introduced. Three-term recurrence relation, Rodrigues-type formula and the q-orthogonality property are given.

  11. Characteristics of Low-q(a) Disruptions in the Compact Toroidal Hybrid

    NASA Astrophysics Data System (ADS)

    Pandya, M. D.; Archmiller, M. C.; Ennis, D. A.; Hartwell, G. J.; Maurer, D. A.

    2014-10-01

    Tokamak disruptions are dramatic events that lead to a sudden loss of plasma confinement. Disruptions that occur at low edge safety-factor, q (a) , limit the operation of tokamaks to q (a) >= 2 . The Compact Toroidal Hybrid (CTH) is a torsatron-tokamak hybrid with a helical field coil and vertical field coils to establish a stellartor equilibrium, while an ohmic coil induces plasma current. A feature of the CTH device is the ability to adjust the vacuum rotational transform, tvac (t =1/q ), by varying the ratio of current in the helical and toroidal field coils. The value of edge tvac can be varied from about 0.02 to 0.3 (qvac (a) ~ 50 to 3.3). Plasma discharges in CTH are routinely observed to operate with q (a) < 2 , and in some cases as low as q (a) ~ 1 . 1 . In CTH, low-q(a) disruptions are observed with a dominant m/n=3/2 precursor. The disruptivity of plasma discharges is over 80% when tvac (a) < 0 . 04 (qvac (a) < 25) and as tvac (a) is increased further, the disruptivity of the plasma discharges decreases. The disruptions are completely suppressed for tvac (a) > 0 . 07 (qvac (a) ~ 14) . This work is supported by US Department of Energy Grant No. DE-FG02-00ER54610.

  12. Effects of Aperture Size on Q factor and Shielding Effectiveness of a Cubic Resonator

    NASA Astrophysics Data System (ADS)

    Parr, Stefan; Chromy, Stephan; Dickmann, Stefan; Schaarschmidt, Martin

    2017-09-01

    The EMC properties of a cubic metallic shield are highly affected by its resonances. At the resonant frequencies, the shielding effectiveness (SE) collapses, which results in high field strengths inside the cavity. This can cause failure or even breakdown of electronic devices inside the shield. The resonant behaviour is mainly determined by the quality or Q factor of the shield. In this paper, the effects of the aperture size on the Q factor and the SE of an electrically large, cubic shield are analysed. At first, a method is developed in order to determine the Q factor based on the resonance behaviour of the shield in time domain. Only the first resonance of the shield is considered therefore. The results are evaluated for different aperture diameters and compared with theory for the Q factor. The dominant coupling mechanism of electromagnetic energy into the shield is thus identified. Then the effect of aperture size on the SE is analysed. The excitation of resonances is very probable if the interfering signal is an ultrawideband (UWB) pulse, which constitutes a typical intentional electromagnetic interference (IEMI) scenario. Therefore, the relation between aperture size and SE is analysed using the theory of the transient SE for a broadband signal with a constant spectral density distribution. The results show, that a <q>worst caseq> aperture size exists, where the SE has its minimum.

  13. Hi-Q Rotor - Low Wind Speed Technology

    SciTech Connect

    Todd E. Mills; Judy Tatum

    2010-01-11

    The project objective was to optimize the performance of the Hi-Q Rotor. Early research funded by the California Energy Commission indicated the design might be advantageous over state-of-the-art turbines for collecting wind energy in low wind conditions. The Hi-Q Rotor is a new kind of rotor targeted for harvesting wind in Class 2, 3, and 4 sites, and has application in areas that are closer to cities, or 'load centers.' An advantage of the Hi-Q Rotor is that the rotor has non-conventional blade tips, producing less turbulence, and is quieter than standard wind turbine blades which is critical to the low-wind populated urban sites. Unlike state-of-the-art propeller type blades, the Hi-Q Rotor has six blades connected by end caps. In this phase of the research funded by DOE's Inventions and Innovation Program, the goal was to improve the current design by building a series of theoretical and numeric models, and composite prototypes to determine a best of class device. Development of the rotor was performed by aeronautical engineering and design firm, DARcorporation. From this investigation, an optimized design was determined and an 8-foot diameter, full-scale rotor was built and mounted using a Bergey LX-1 generator and furling system which were adapted to support the rotor. The Hi-Q Rotor was then tested side-by-side against the state-of-the-art Bergey XL-1 at the Alternative Energy Institute's Wind Test Center at West Texas State University for six weeks, and real time measurements of power generated were collected and compared. Early wind tunnel testing showed that the cut-in-speed of the Hi-Q rotor is much lower than a conventional tested HAWT enabling the Hi-Q Wind Turbine to begin collecting energy before a conventional HAWT has started spinning. Also, torque at low wind speeds for the Hi-Q Wind Turbine is higher than the tested conventional HAWT and enabled the wind turbine to generate power at lower wind speeds. Based on the data collected, the results of

  14. Coordinates of the quantum plane as q-tensor operators in U{sub q} (su(2) * su(2))

    SciTech Connect

    Biedenharn, L.C.; Lohe, M.A.

    1995-01-13

    The relation between the set of transformations M{sub q}(2) of the quantum plane and the quantum universal enveloping algebra U{sub q}(u(2)) is investigated by constructing representations of the factor algebra U{sub q} (u(2) * u(2)). The non-commuting coordinates of M{sub q}(2), on which U{sub q}(2) * U{sub q}(2) acts, are realized as q-spinors with respect to each U{sub q}(u(2)) algebra. The representation matrices of U{sub q}(2) are constructed as polynomials in these spinor components. This construction allows a derivation of the commutation relations of the noncommuting coordinates of M{sub q}(2) directly from properties of U{sub q}(u(2)). The generalization of these results to U{sub q}(u(n)) and M{sub q}(n) is also discussed.

  15. Misunderstandings about Q and 'Cochran's Q test' in meta-analysis.

    PubMed

    Hoaglin, David C

    2016-02-20

    Many meta-analyses report using 'Cochran's Q test' to assess heterogeneity of effect-size estimates from the individual studies. Some authors cite work by W. G. Cochran, without realizing that Cochran deliberately did not use Q itself to test for heterogeneity. Further, when heterogeneity is absent, the actual null distribution of Q is not the chi-squared distribution assumed for 'Cochran's Q test'. This paper reviews work by Cochran related to Q. It then discusses derivations of the asymptotic approximation for the null distribution of Q, as well as work that has derived finite-sample moments and corresponding approximations for the cases of specific measures of effect size. Those results complicate implementation and interpretation of the popular heterogeneity index I(2) . Also, it turns out that the test-based confidence intervals used with I(2) are based on a fallacious approach. Software that outputs Q and I(2) should use the appropriate reference value of Q for the particular measure of effect size and the current meta-analysis. Q is a key element of the popular DerSimonian-Laird procedure for random-effects meta-analysis, but the assumptions of that procedure and related procedures do not reflect the actual behavior of Q and may introduce bias. The DerSimonian-Laird procedure should be regarded as unreliable. Copyright © 2015 John Wiley & Sons, Ltd.

  16. Predisposition for breast cancer in carriers of constitutional translocation 11q; 22q

    SciTech Connect

    Lindblom, A.; Dumanski, J.; White, I.; Nordenskjoeld, M.; Larsson, C.; Sandelin, K.; Iselius, L. )

    1994-05-01

    A translocation between the long arms of chromosomes 11 and 22, t(11;22)(q23;q11), is the most frequent constitutional reciprocal translocation in man. This chromosome abnormality has not previously been reported to be associated with an increased risk for neoplasia. The observation of one patient with a constitutional translocation t(11q;22q) and breast cancer prompted study of the relationship between these two conditions. The incidence of breast cancer was determined in carriers of t(11q;22q). The karyotypes were determined by QFQ-banding, and the breakpoints were then further characterized by fluorescent in situ hybridization. Eight families with a total of 22 balanced carriers were found. In five of these families there was one case of breast cancer each. In another family a case of an unknown malignancy was reported in one member. No other malignancies were found among these patients. The number of breast cancer cases were significantly higher than expected among the translocation carriers (P<.0001). The chromosomal breakpoints showed the same localization with the markers used, in the seven families studied. The association of constitutional translocation t(11q;22q) and breast cancer identifies a subset of patients with a highly increased risk for breast cancer who would benefit from counseling and screening. It also suggests the involvement of genes on 11q and/or 22q, in the tumorigenesis of breast cancer. 36 refs., 2 figs.

  17. Genetics Home Reference: 5q minus syndrome

    MedlinePlus

    ... shortage of these cells ( anemia ). In addition, the red blood cells that are present are unusually large (macrocytic). Although many people with 5q- syndrome have no symptoms related to anemia, especially in the early ...

  18. Environmental Chemistry Methods (ECM) Index - Q

    EPA Pesticide Factsheets

    Laboratories use testing methods to identify pesticides in water and soil. Environmental chemistry methods test soil and water samples to determine the fate of pesticides in the environment. Find methods for chemicals with Q as the first character.

  19. Bayesian Estimation of the DINA Q matrix.

    PubMed

    Chen, Yinghan; Culpepper, Steven Andrew; Chen, Yuguo; Douglas, Jeffrey

    2017-08-31

    Cognitive diagnosis models are partially ordered latent class models and are used to classify students into skill mastery profiles. The deterministic inputs, noisy "and" gate model (DINA) is a popular psychometric model for cognitive diagnosis. Application of the DINA model requires content expert knowledge of a Q matrix, which maps the attributes or skills needed to master a collection of items. Misspecification of Q has been shown to yield biased diagnostic classifications. We propose a Bayesian framework for estimating the DINA Q matrix. The developed algorithm builds upon prior research (Chen, Liu, Xu, & Ying, in J Am Stat Assoc 110(510):850-866, 2015) and ensures the estimated Q matrix is identified. Monte Carlo evidence is presented to support the accuracy of parameter recovery. The developed methodology is applied to Tatsuoka's fraction-subtraction dataset.

  20. Current laboratory diagnosis of Q fever.

    PubMed

    Scola, Bernard La

    2002-10-01

    Q fever is a worldwide zoonosis caused by the strictly intracellular bacterium Coxiella burnetii. Among symptomatic patients (one-half of patients remain asymptomatic), acute Q fever most frequently manifests as a self-limited febrile illness, pneumonia, or hepatitis. Endocarditis is the predominant form of chronic Q fever. All the classical techniques of bacteriology may be used for diagnosis of C burnetii infection. Nonetheless, because of the risk of contamination, isolation must be performed in biosafety level 3 laboratories. Moreover, to date no diagnostic tests for detection by polymerase chain reaction or specific antibodies for immunochemistry are available commercially. Hence, Q fever is diagnosed in most cases by serology. The most reliable technique appears to be micro-immunofluorescence, which exhibits both good sensitivity and specificity. A wider use of this serology in cases of blood culture-negative endocarditis, atypical pneumonia, unexplained fever, and hepatitis should lead to an increase of diagnosed cases. Copyright 2002, Elsevier Science (USA). All rights reserved.

  1. Exploration Enterprise Workshop - Q&A

    NASA Image and Video Library

    Q&A session from May 25, 2010, at the end of Day 1 of NASA's Exploration Enterprise Workshop held in Galveston, TX. The purpose of this workshop was to present NASA's initial plans for the potentia...

  2. Chromosome 10q tetrasomy: First reported case

    SciTech Connect

    Blackston, R.D.; May, K.M.; Jones, F.D.

    1994-09-01

    While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

  3. [22q11.2 microdeletion].

    PubMed

    Schneider, M; Eliez, S

    2010-04-01

    22q11.2 deletion syndrome (22q11DS), most frequently caused by a de novo microdeletion on the long arm of chromosome 22, is one of the most common neurogenetic syndromes. The cognitive and behavioral characteristics associated with the 22q11.2 phenotype can be quite heterogeneous, part of the reason the syndrome is often detected very late, if at all. Though in individuals with more severe cardiac, respiratory, or speech and language problems, 22q11DS is more easily detected at a young age. The cognitive profile in 22q11DS varies between borderline IQ and mild mental retardation. Less than half children have mental retardation but a majority suffer from learning difficulties. It is also typically characterized by a verbal-visual dissociation, with verbal abilities higher than visuo-spatial and abstract reasoning. Psychiatric comorbidity is also frequent in 22q11DS, and the presence of psychotic symptoms in pre-adolescence may be unique to the syndrome. In older adolescents and young adults, social withdrawal often becomes more intense and can be an indicator of psychiatric disorder. Neuroimaging studies in 22q11DS indicate different patterns of structural alterations in affected children and adults that directly relate to cognitive impairments in the syndrome. For these reasons, we believe that treatment of persons affected by 22q11DS should include periodic evaluations and frequent clinical check-ups that integrate recommendations for medical, speech, psychiatric, and academic problems. Copyright 2009 Elsevier Masson SAS. All rights reserved.

  4. Coenzyme Q10: Can It Prevent Statin Side Effects?

    MedlinePlus

    ... Q10: Can it prevent statin side effects? Can coenzyme Q10 reduce the risk of side effects from ... Francisco Lopez-Jimenez, M.D. At this time, coenzyme Q10 isn't universally recommended for preventing side ...

  5. Isochromosome 17q in Chronic Lymphocytic Leukemia

    PubMed Central

    Alhourani, Eyad; Rincic, Martina; Melo, Joana B.; Carreira, Isabel M.; Glaser, Anita; Pohle, Beate; Schlie, Cordula; Liehr, Thomas

    2015-01-01

    In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH). Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q); surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the TP53 deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q); it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone. PMID:26697230

  6. Radial q-space sampling for DSI.

    PubMed

    Baete, Steven H; Yutzy, Stephen; Boada, Fernando E

    2016-09-01

    Diffusion spectrum imaging (DSI) has been shown to be an effective tool for noninvasively depicting the anatomical details of brain microstructure. Existing implementations of DSI sample the diffusion encoding space using a rectangular grid. Here we present a different implementation of DSI whereby a radially symmetric q-space sampling scheme for DSI is used to improve the angular resolution and accuracy of the reconstructed orientation distribution functions. Q-space is sampled by acquiring several q-space samples along a number of radial lines. Each of these radial lines in q-space is analytically connected to a value of the orientation distribution functions at the same angular location by the Fourier slice theorem. Computer simulations and in vivo brain results demonstrate that radial diffusion spectrum imaging correctly estimates the orientation distribution functions when moderately high b-values (4000 s/mm2) and number of q-space samples (236) are used. The nominal angular resolution of radial diffusion spectrum imaging depends on the number of radial lines used in the sampling scheme, and only weakly on the maximum b-value. In addition, the radial analytical reconstruction reduces truncation artifacts which affect Cartesian reconstructions. Hence, a radial acquisition of q-space can be favorable for DSI. Magn Reson Med 76:769-780, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  7. Interactive model building for Q-learning.

    PubMed

    Laber, Eric B; Linn, Kristin A; Stefanski, Leonard A

    2014-10-20

    Evidence-based rules for optimal treatment allocation are key components in the quest for efficient, effective health care delivery. Q-learning, an approximate dynamic programming algorithm, is a popular method for estimating optimal sequential decision rules from data. Q-learning requires the modeling of nonsmooth, nonmonotone transformations of the data, complicating the search for adequately expressive, yet parsimonious, statistical models. The default Q-learning working model is multiple linear regression, which is not only provably misspecified under most data-generating models, but also results in nonregular regression estimators, complicating inference. We propose an alternative strategy for estimating optimal sequential decision rules for which the requisite statistical modeling does not depend on nonsmooth, nonmonotone transformed data, does not result in nonregular regression estimators, is consistent under a broader array of data-generation models than Q-learning, results in estimated sequential decision rules that have better sampling properties, and is amenable to established statistical approaches for exploratory data analysis, model building, and validation. We derive the new method, IQ-learning, via an interchange in the order of certain steps in Q-learning. In simulated experiments IQ-learning improves on Q-learning in terms of integrated mean squared error and power. The method is illustrated using data from a study of major depressive disorder.

  8. Alerts and Notices (Devices)

    MedlinePlus

    ... Medical Devices Medical Device Safety Safety Communications Safety Communications Share Tweet Linkedin Pin it More sharing options ... Older safety communications are listed below. Older Safety Communications 2015 Safety Communications 2014 Safety Communications 2013 Safety ...

  9. Liquid Crystal Devices.

    ERIC Educational Resources Information Center

    Bradshaw, Madeline J.

    1983-01-01

    The nature of liquid crystals and several important liquid crystal devices are described. Ideas for practical experiments to illustrate the properties of liquid crystals and their operation in devices are also described. (Author/JN)

  10. Sealed container sampling device

    NASA Technical Reports Server (NTRS)

    Hennigan, T. J.

    1969-01-01

    Sampling device, by means of a tapered needle, pierces a sealed container while maintaining the seal and either evacuates or pressurizes the container. This device has many applications in the chemical, preservative and battery-manufacturing industries.

  11. GAS DISCHARGE DEVICES

    DOEpatents

    Arrol, W.J.; Jefferson, S.

    1957-08-27

    The construction of gas discharge devices where the object is to provide a gas discharge device having a high dark current and stabilized striking voltage is described. The inventors have discovered that the introduction of tritium gas into a discharge device with a subsequent electrical discharge in the device will deposit tritium on the inside of the chamber. The tritium acts to emit beta rays amd is an effective and non-hazardous way of improving the abovementioned discharge tube characteristics

  12. Pulse flux measuring device

    DOEpatents

    Riggan, William C.

    1985-01-01

    A device for measuring particle flux comprises first and second photodiode detectors for receiving flux from a source and first and second outputs for producing first and second signals representing the flux incident to the detectors. The device is capable of reducing the first output signal by a portion of the second output signal, thereby enhancing the accuracy of the device. Devices in accordance with the invention may measure distinct components of flux from a single source or fluxes from several sources.

  13. Devices for continence.

    PubMed

    Smith, D A

    1994-09-01

    Ameliorating the acute and chronic forms of incontinence is usually possible. When the functional status of the patient prohibits toileting, then devices are often necessary. The practicing nurse must make decisions on what devices are appropriate and how to teach clients to use them. Often, knowing the device exists is a start in the nurse's ability to eliminate functional incontinence. This article focuses on devices that collect urine, inhibit incontinence, and aid staff and clients to use the toilet.

  14. Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).

    PubMed Central

    Sheer, D.; Lister, T. A.; Amess, J.; Solomon, E.

    1985-01-01

    Cytogenetic analysis was carried out on peripheral blood cultures from seven patients with acute promyelocytic leukaemia (APL-M3). A reciprocal 15;17 chromosome translocation, t(15q+;17q-), was found in all cases, and the breakpoints estimated to be 15q22 and 17q12-21. In addition to the t(15q+;17q-), trisomy 10 was found in 50% of cells analysed in one case. These results suggest that the 15;17 chromosome translocation may be observed in most cases of APL where the leukaemic cells are cultured before cytogenetic analysis is performed. The use of conditioned media in the culture of leukaemic cells is also described. Images Figure 1 PMID:3860247

  15. Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: a case presentation.

    PubMed

    Curley, Cameron; Kennedy, Glen; Haughton, Anne; Love, Amanda; McCarthy, Catherine; Boyd, Andrew

    2010-06-01

    Diabetes insipidus (DI) is a rare presenting complication of acute myeloid leukaemia (AML). Typically, the combination of DI and AML is associated with structural abnormalities of the neurohypophysis. We present a case of AML and DI presenting without any abnormalities of the neurohypophysis on radiological scanning and with normal cerebrospinal fluid examination. The AML karyotype at presentation was characterized by the presence of a t(3; 3)(q21; q26) translocation and monosomy 7. After treatment with induction chemotherapy, the patient achieved a complete remission and his DI resolved. At subsequent AML relapse, characterized by a complex karyotype without the t(3; 3)(q21; q26) translocation or monosomy 7, DI did not recur. Our case provides clinical support to the hypothesis that the t(3; 3)(q21; q26) translocation and/or monosomy 7 in AML may directly result in dysregulation of transcription factors resulting in development of DI in AML patients.

  16. Removal of Tattoos by Q-Switched Nanosecond Lasers.

    PubMed

    Karsai, Syrus

    2017-01-01

    Tattoo removal by Q-switched nanosecond laser devices is generally a safe and effective method, albeit a time-consuming one. Despite the newest developments in laser treatment, it is still not possible to remove every tattoo completely and without complications. Incomplete removal remains one of the most common challenges. As a consequence, particular restraint should be exercised when treating multicoloured tattoos, and patients need to be thoroughly informed about remaining pigment. Other frequent adverse effects include hyper- and hypopigmentation as well as ink darkening; the latter is particularly frequent in permanent make-up. Scarring is also possible, although it is rare when treatment is performed correctly. It is becoming more widespread for laser operators to encounter allergic reactions and even malignant tumours in tattoos, and treating these conditions requires a nuanced approach. © 2017 S. Karger AG, Basel.

  17. Twin photon pairs in a high-Q silicon microresonator

    NASA Astrophysics Data System (ADS)

    Rogers, Steven; Lu, Xiyuan; Jiang, Wei C.; Lin, Qiang

    2015-07-01

    We report the generation of high-purity twin photon pairs through cavity-enhanced non-degenerate four-wave mixing (FWM) in a high-Q silicon microdisk resonator. Twin photon pairs are created within the same cavity mode and are consequently expected to be identical in all degrees of freedom. The device is able to produce twin photons at telecommunication wavelengths with a pair generation rate as large as (3.96 ± 0.03) × 105 pairs/s, within a narrow bandwidth of 0.72 GHz. A coincidence-to-accidental ratio of 660 ± 62 was measured, the highest value reported to date for twin photon pairs, at a pair generation rate of (2.47 ± 0.04) × 104 pairs/s. Through careful engineering of the dispersion matching window, we have reduced the ratio of photons resulting from degenerate FWM to non-degenerate FWM to less than 0.15.

  18. Theory of the optimally coupled Q-switched laser

    NASA Technical Reports Server (NTRS)

    Degnan, John J.

    1989-01-01

    The general equations describing Q-switched laser operation are transcendental in nature and require numerical solutions, which greatly complicates the optimization of real devices. Here, it is shown that, using the mathematical technique of Lagrange multipliers, one can derive simple analytic expressions for all of the key parameters of the optimally coupled laser, i.e., one which uses an optimum reflector to obtain maximum laser efficiency for a given pump level. These parameters can all be expressed as functions of a single dimensionless variable z, defined as the ratio of the unsaturated small-signal gain to the dissipative (nonuseful) optical loss, multiplied by a few simple constants. Laser design tradeoff studies and performance projections can be accomplished quickly with the help of several graphs and a simple hand calculator. Sample calculations for a high-gain Nd:YAG and a low-gain alexandrite laser are presented as illustrations of the technique.

  19. Theory of the optimally coupled Q-switched laser

    NASA Technical Reports Server (NTRS)

    Degnan, John J.

    1989-01-01

    The general equations describing Q-switched laser operation are transcendental in nature and require numerical solutions, which greatly complicates the optimization of real devices. Here, it is shown that, using the mathematical technique of Lagrange multipliers, one can derive simple analytic expressions for all of the key parameters of the optimally coupled laser, i.e., one which uses an optimum reflector to obtain maximum laser efficiency for a given pump level. These parameters can all be expressed as functions of a single dimensionless variable z, defined as the ratio of the unsaturated small-signal gain to the dissipative (nonuseful) optical loss, multiplied by a few simple constants. Laser design tradeoff studies and performance projections can be accomplished quickly with the help of several graphs and a simple hand calculator. Sample calculations for a high-gain Nd:YAG and a low-gain alexandrite laser are presented as illustrations of the technique.

  20. A malformed newborn with 9p and 4q trisomy.

    PubMed

    Fryns, J P; Azou, M; Devliegher, H; Eggermont, E; van den Berghe, H

    1981-01-01

    A malformed male newborn with partial trisomy 9p (qter-9q13) and distal 4q trisomy (4qter-4q31), being the unbalanced product of a balanced reciprocal translocation in the mother karyotype: 46,XX,t(4;9)(q31;q13) is reported. Besides the typical craniofacial stigmata of pure 9q trisomy the child presented with poor neurological condition and failure to thrive.

  1. 46 CFR 117.72 - Personal flotation devices carried in addition to life jackets.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Personal flotation devices carried in addition to life... devices carried in addition to life jackets. (a) Equipment carried under this section is not acceptable in....064 in subchapter Q of this chapter, or other standard specified by the Commandant, may be carried as...

  2. 46 CFR 180.72 - Personal flotation devices carried in addition to life jackets.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Personal flotation devices carried in addition to life... Jackets § 180.72 Personal flotation devices carried in addition to life jackets. (a) Equipment carried...,” approved in accordance with § 160.064 in subchapter Q of this chapter, or other standard specified by the...

  3. 46 CFR 180.72 - Personal flotation devices carried in addition to life jackets.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Personal flotation devices carried in addition to life... Jackets § 180.72 Personal flotation devices carried in addition to life jackets. (a) Equipment carried...,” approved in accordance with § 160.064 in subchapter Q of this chapter, or other standard specified by the...

  4. Photovoltaic device and method

    DOEpatents

    Cleereman, Robert; Lesniak, Michael J.; Keenihan, James R.; Langmaid, Joe A.; Gaston, Ryan; Eurich, Gerald K.; Boven, Michelle L.

    2015-11-24

    The present invention is premised upon an improved photovoltaic device ("PVD") and method of use, more particularly to an improved photovoltaic device with an integral locator and electrical terminal mechanism for transferring current to or from the improved photovoltaic device and the use as a system.

  5. Photovoltaic device and method

    DOEpatents

    Cleereman, Robert J; Lesniak, Michael J; Keenihan, James R; Langmaid, Joe A; Gaston, Ryan; Eurich, Gerald K; Boven, Michelle L

    2015-01-27

    The present invention is premised upon an improved photovoltaic device ("PVD") and method of use, more particularly to an improved photovoltaic device with an integral locator and electrical terminal mechanism for transferring current to or from the improved photovoltaic device and the use as a system.

  6. Amorphous silicon photovoltaic devices

    DOEpatents

    Carlson, David E.; Lin, Guang H.; Ganguly, Gautam

    2004-08-31

    This invention is a photovoltaic device comprising an intrinsic or i-layer of amorphous silicon and where the photovoltaic device is more efficient at converting light energy to electric energy at high operating temperatures than at low operating temperatures. The photovoltaic devices of this invention are suitable for use in high temperature operating environments.

  7. Organic photosensitive devices

    DOEpatents

    Rand, Barry P; Forrest, Stephen R

    2013-11-26

    The present invention generally relates to organic photosensitive optoelectronic devices. More specifically, it is directed to organic photosensitive optoelectronic devices having a photoactive organic region containing encapsulated nanoparticles that exhibit plasmon resonances. An enhancement of the incident optical field is achieved via surface plasmon polariton resonances. This enhancement increases the absorption of incident light, leading to a more efficient device.

  8. Articulating feedstock delivery device

    DOEpatents

    Jordan, Kevin

    2013-11-05

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  9. 18q- and 18q+ mosaicism in a mentally retarded boy

    SciTech Connect

    Ausems, M.G.E.M.; Bhola, S.L.; France, H.F. de; Post-Blok, C.A.; Hennekam, R.C.M.

    1994-11-15

    A mentally retarded boy was found to have an unusual chromosomal mosaicism [46,XY,del(18) (q22)/46,XY,iso psu dic(18)(q23)]. The clinical manifestations are compatible with the 18q- syndrome. The chromosome alteration was defined by high resolution banding and fluorescence in situ hybridization (FISH). A mechanism to explain the origin of the two cell lines is presented and discussed. 6 refs., 4 figs., 1 tab.

  10. q-generalized representation of the d-dimensional Dirac delta and q-Fourier transform

    NASA Astrophysics Data System (ADS)

    Sicuro, Gabriele; Tsallis, Constantino

    2017-08-01

    We introduce a generalized representation of the Dirac delta function in d dimensions in terms of q-exponential functions. We apply this new representation to the study of the so-called q-Fourier transform and we establish the analytical procedure through which it can be inverted for any value of d. We finally illustrate the effect of the q-deformation on the Gibbs phenomenon of Fourier series expansions.

  11. Complex q-ANALYSIS and Scalar Field Theory on a q-LATTICE

    NASA Astrophysics Data System (ADS)

    Ubriaco, Marcelo R.

    We develop the basic formalism of complex q-analysis to study the solutions of second order q-difference equations which reduce, in the q → 1 limit, to the ordinary Laplace equation in Euclidean and Minkowski space. After defining an inner product on the function space we construct and study the properties of the solutions, and then apply this formalism to the Schrödinger equation and two-dimensional scalar field theory.

  12. Genotype-phenotype correlation in 13q13.3-q21.3 deletion.

    PubMed

    Tosca, Lucie; Brisset, Sophie; Petit, François M; Metay, Corinne; Latour, Stéphanie; Lautier, Benoît; Lebas, Axel; Druart, Luc; Picone, Olivier; Mas, Anne-Elisabeth; Prévot, Sophie; Tardieu, Marc; Goossens, Michel; Tachdjian, Gérard

    2011-01-01

    Pure interstitial deletions of the long arm of chromosome 13 are correlated with variable phenotypes according to the size and the location of the deleted region. Deletions involving the 13q13q21 region are rare. In order to establish interstitial 13q genotype-phenotype correlation, we used high resolution 244K oligonucleotide array in addition to conventional karyotype and molecular (fluorescent in situ hybridization, microsatellite markers analysis) techniques in two independent probands carrying a deletion 13q13 to 13q21. First patient was a 3-year-old girl with mental retardation and dysmorphy carrying a 13q13.3q21.31 de novo deletion diagnosed post-natally. The second one was a fetus with de novo del(13)(q14q21.2) associated with first trimester increased nuchal translucency. We showed that specific dysmorphic features (macrocephaly, high forehead, hypertelorism, large nose, large and malformed ears and retrognathia) were correlated to the common 13q14q21 chromosomal segment. Physical examination revealed overgrowth with global measurement up to the 95th percentile in both probands. This is the second description of overgrowth in patients carrying a 13q deletion. Haploinsufficiency of common candidates genes such as CKAP2, SUGT1, LECT1, DCLK1 and SMAD9, involved in cell division and bone development, is a possible mechanism that could explain overgrowth in both patients. This study underlines also that cytogenetic analysis could be performed in patients with overgrowth. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  13. Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source

    NASA Astrophysics Data System (ADS)

    Yang, Y.; Sun, L. T.; Feng, Y. C.; Fang, X.; Lu, W.; Zhang, W. H.; Cao, Y.; Zhang, X. Z.; Zhao, H. W.

    2014-08-01

    Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented.

  14. Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source.

    PubMed

    Yang, Y; Sun, L T; Feng, Y C; Fang, X; Lu, W; Zhang, W H; Cao, Y; Zhang, X Z; Zhao, H W

    2014-08-01

    Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented.

  15. Partial trisomy 18 in a family with a translocation (18;21)(q21;q22).

    PubMed Central

    Niazi, M; Coleman, D V; Saldaña-Garcia, P

    1978-01-01

    A family is described in which 2 sibs had similar congenital abnormalities. Chromosome investigation of the mother and another child disclosed they were carriers of a translocation t(18;21)(q21;q22). The karyotype of one of the abnormal infants was determined and was found to be consistent with partial trisomy 18,46,XY,-21,+der (21),t(18;21) ((18pter leads to 18q21::21q22 leads to 2 lqter)mat. Images PMID:641950

  16. Allelic loss of chromosomes 16q and 10q in human prostate cancer

    SciTech Connect

    Carter, B.S.; Ewing, C.M.; Ward, W.S.; Treiger, B.F.; Isaacs, W.B.; Epstein, J.I. ); Aalders, T.W.; Schalken, J.A. )

    1990-11-01

    Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes. The authors have examines allelic loss in the most common tumor in men, prostate cancer. Twenty-eight prostate cancer specimens have been examined for loss of heterozygosity at 11 different chromosomal arms including 3p, 7q, 9q, 10p, 10q, 11p, 13q, 16p, 17p, and 18q. Fifty-four percent (13/24) of clinically localized tumors and 4 of 4 metastatic tumors showed loss of heterozygosity on at least one chromosome. Chromosomes 16q and 10q exhibited the highest frequency of loss of heterozygosity with 30% of tumors showing loss at these chromosomes. These data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.

  17. Robertsonian (15q;15q) translocation in a child with Angelman syndrome: Evidence of uniparental disomy

    SciTech Connect

    Tonk, V.; Schultz, R.A.; Wilson, G.N.; Schultz, R.A.

    1996-12-30

    A balanced Robertsonian translocation 45,XY,t(15q15q) was detected in a patient with mental retardation, microcephaly, and hypertonia. Deletion of the 15q11q13 region was unlikely based on fluorescence in situ hybridization studies that revealed hybridization of appropriate DNA probes to both arms of the Robertsonian chromosome. Inheritance of alleles from 13 highly polymorphic DNA markers on chromosome 15 showed paternal uniparental isodisomy. The clinical, cytogenetic, and molecular results are consistent with a diagnosis of Angelman syndrome. 8 refs., 3 figs.

  18. Planet Population Statistics With Kepler Q1-Q16: Stellar Effective Temperature Dependence

    NASA Astrophysics Data System (ADS)

    Burke, Christopher J.; Mullally, Fergal; Christiansen, Jessie; Huber, Daniel; Seader, Shawn; Catanzarite, Joseph; Bryson, Steve; Coughlin, Jeffrey; Rowe, Jason; Thompson, Susan E.; Clarke, Bruce; Tenenbaum, Peter; Batalha, Natalie M.; Haas, Michael R.; Jenkins, Jon Michael; Kepler Project

    2015-01-01

    We explore extrasolar planet population statistics and the dependence of planet occurrence rates on stellar effective temperature from analysis of the Kepler Q1-Q16 planet candidate sample. The analysis takes advantage of the recent work on the Q1-Q16 Kepler planet candidate sample, extensive Monte-Carlo transit signal injection and recovery tests of the Kepler Pipeline, and updates to the stellar parameters provided by the Kepler Stellar Working Group. Results focus of intermediate orbital periods, 50< Porb<300 day, where astrophysical and instrumental contamination of the planet sample is low.

  19. Portable data collection device

    DOEpatents

    French, P.D.

    1996-06-11

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of a time. 7 figs.

  20. Portable data collection device

    DOEpatents

    French, Patrick D.

    1996-01-01

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of a time.

  1. Active cleaning technique device

    NASA Technical Reports Server (NTRS)

    Shannon, R. L.; Gillette, R. B.

    1973-01-01

    The objective of this program was to develop a laboratory demonstration model of an active cleaning technique (ACT) device. The principle of this device is based primarily on the technique for removing contaminants from optical surfaces. This active cleaning technique involves exposing contaminated surfaces to a plasma containing atomic oxygen or combinations of other reactive gases. The ACT device laboratory demonstration model incorporates, in addition to plasma cleaning, the means to operate the device as an ion source for sputtering experiments. The overall ACT device includes a plasma generation tube, an ion accelerator, a gas supply system, a RF power supply and a high voltage dc power supply.

  2. Biomechanics of Interspinous Devices

    PubMed Central

    Parchi, Paolo D.; Evangelisti, Gisberto; Vertuccio, Antonella; Piolanti, Nicola; Andreani, Lorenzo; Cervi, Valentina; Giannetti, Christian; Calvosa, Giuseppe; Lisanti, Michele

    2014-01-01

    A number of interspinous devices (ISD) have been introduced in the lumbar spine implant market. Unfortunately, the use of these devices often is not associated with real comprehension of their biomechanical role. The aim of this paper is to review the biomechanical studies about interspinous devices available in the literature to allow the reader a better comprehension of the effects of these devices on the treated segment and on the adjacent segments of the spine. For this reason, our analysis will be limited to the interspinous devices that have biomechanical studies published in the literature. PMID:25114923

  3. Unitary lens semiconductor device

    DOEpatents

    Lear, K.L.

    1997-05-27

    A unitary lens semiconductor device and method are disclosed. The unitary lens semiconductor device is provided with at least one semiconductor layer having a composition varying in the growth direction for unitarily forming one or more lenses in the semiconductor layer. Unitary lens semiconductor devices may be formed as light-processing devices such as microlenses, and as light-active devices such as light-emitting diodes, photodetectors, resonant-cavity light-emitting diodes, vertical-cavity surface-emitting lasers, and resonant cavity photodetectors. 9 figs.

  4. Unitary lens semiconductor device

    DOEpatents

    Lear, Kevin L.

    1997-01-01

    A unitary lens semiconductor device and method. The unitary lens semiconductor device is provided with at least one semiconductor layer having a composition varying in the growth direction for unitarily forming one or more lenses in the semiconductor layer. Unitary lens semiconductor devices may be formed as light-processing devices such as microlenses, and as light-active devices such as light-emitting diodes, photodetectors, resonant-cavity light-emitting diodes, vertical-cavity surface-emitting lasers, and resonant cavity photodetectors.

  5. High Q-factor colloidal nanocrystal-based vertical microcavity by hot embossing technology

    NASA Astrophysics Data System (ADS)

    Martiradonna, Luigi; Carbone, Luigi; De Giorgi, Milena; Manna, Liberato; Gigli, Giuseppe; Cingolani, Roberto; De Vittorio, Massimo

    2006-05-01

    We report on the fabrication and optical characterization of vertical hybrid microcavities in which a layer of colloidal nanocrystals dispersed in an organic matrix is embedded between two inorganic mirrors. The devices are fabricated by a technique based on the unconventional use of the hot embossing technology, which allows a very fine control of the cavity length. The technique exploits a λ-thick microstructured dielectric top mirror pressed onto the bottom one, previously coated with the active layer, to sandwich the cavity and precisely control its thickness. Room-temperature photoluminescence measurements show a Q factor as high as 146 for our devices.

  6. Simultaneous electrical and optical readout of graphene-coated high Q silicon nitride resonators

    NASA Astrophysics Data System (ADS)

    Adiga, V. P.; De Alba, R.; Storch, I. R.; Yu, P. A.; Ilic, B.; Barton, R. A.; Lee, S.; Hone, J.; McEuen, P. L.; Parpia, J. M.; Craighead, H. G.

    2013-09-01

    Resonant mechanics of high quality factor (Q) graphene coated silicon nitride devices have been explored using optical and electrical transduction schemes. With the addition of the graphene layer, we retain the desirable mechanical properties of silicon nitride but utilize the electrical and optical properties of graphene to transduce and tune the resonant motion by both optical and electrical means. By positioning the graphene-on-silicon-nitride drums in a tunable optical cavity, we observe position dependent damping and resonant frequency control of the devices due to optical absorption by graphene.

  7. Support loss and Q factor enhancement for a rocking mass microgyroscope.

    PubMed

    Wang, Xiong; Xiao, Dingbang; Zhou, Zelong; Wu, Xuezhong; Chen, Zhihua; Li, Shengyi

    2011-01-01

    A rocking mass gyroscope (RMG) is a kind of vibrating mass gyroscope with high sensitivity, whose driving mode and sensing mode are completely uniform. MEMS RMG devices are a research hotspot now because they have the potential to be used in space applications. Support loss is the dominant energy loss mechanism influencing their high sensitivity. An accurate analytical model of support loss for RMGs is presented to enhance their Q factors. The anchor type and support loss mechanism of an RMG are analyzed. Firstly, the support loads, powers flowing into support structure, and vibration energy of an RMG are all developed. Then the analytical model of support loss for the RMG is developed, and its sensitivities to the main structural parameters are also analyzed. High-Q design guidelines for rocking mass microgyroscopes are deduced. Finally, the analytical model is validated by the experimental data and the data from the existing literature. The thicknesses of the prototypes are reduced from 240 μm to 60 μm, while Q factors increase from less than 150 to more than 800. The derived model is general and applicable to various beam resonators, providing significant insight to the design of high-Q MEMS devices.

  8. Electrochromic display device

    NASA Astrophysics Data System (ADS)

    Nicholson, M. M.

    1984-07-01

    This invention relates to electrochromic devices. In one aspect it relates to electrically controllable display devices. In another aspect it relates to electrically tunable optical or light filters. In yet another aspect it relates to a chemical sensor device which employs a color changing film. There are many uses for electrically controllable display devices. A number of such devices have been in commercial use for some time. These display devices include liquid crystal displays, light emitting diode displays, plasma displays, and the like. Light emitting diode displays and plasma display panels both suffer from the fact that they are active. Light emissive devices which require substantial power for their operation, In addition, it is difficult to fabricate light emitting diode displays in a manner which renders them easily distinguishable under bright ambient illumination. Liquid crystal displays suffer from the disadvantage that they are operative only over a limited temperature range and have substantially no memory within the liquid crystal material.

  9. Partial monosomy 8q and partial trisomy 9q due to the maternal translocation t(8;9(q24.3;q34.1): a case report.

    PubMed

    Tos, T; Alp, M Y; Eker, H K; Cebi, A H; Ikbal, M

    2014-01-01

    Partial trisomy 9q34-qter and partial monosomy 8q24.3-qter are very rare chromosomal abnormalities. Characteristic features of partial trisomy 9q34-qter are hypotonia, developmental delay, mild intellectual disability, dolichocephaly, distinct facial phenotype, long and thin fingers, and cardiac anomalies. Unlike the partial trisomy 9q34-qter, partial monosomy 8q24.3-qter has no distinct phenotype. Here we report a four years old female patient with partial trisomy 9q34-qter and partial monosomy 8q24.3-qter due to the maternal translocation t(8;9)(q24.3;q34. I). She has developmental delay, brachycephaly, facial dysmorphism, hand and foot anomalies, bilateral hearing loss, cardiac defect and abnormal brain MRI findings. To the best of our knowledge, this is the first report of the combination of partial trisomy 9q and partial monosomy 8q.

  10. Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma

    PubMed Central

    Kanayama, H.; Lui, W.; Takahashi, M.; Naroda, T.; Kedra, D.; Wong, F. K.; Kuroki, Y.; Nakahori, Y.; Larsson, C.; Kagawa, S.; Teh, B. T.

    2001-01-01

    Four cases of late onset clear cell renal cell carcinoma (RCC), a case of gastric cancer, and a case of exocrine pancreatic cancer were identified in a Japanese family. In order to elucidate the underlying mechanism for tumorigenesis in this family, extensive genetic studies were performed including routine and spectral karyotyping (SKY), fluorescence in situ hybridisation (FISH), comparative genomic hybridisation (CGH), loss of heterozygosity studies (LOH), and VHL mutation analysis. A germline translocation t(1;3)(q32-q41;q13-q21) was identified by karyotyping in five members of the family including all three RCC cases tested. The translocation was refined to t(1;3)(q32;q13.3) by FISH analysis using locus specific genomic clones, and the two breakpoints were mapped to a 5 cM region in 3q13.3 and a 3.6 cM region in 1q32. Both CGH and allelotyping using microsatellite markers showed loss of the derivative chromosome 3 carrying a 1q segment in the three familial RCCs analysed. Additional chromosomal imbalances were identified by CGH, including amplifications of chromosomes 5 and 7 and loss of 8p and 9. No germline VHL mutation was found but two different somatic mutations, a splice (IVS1-2A>C) and a frameshift (726delG), were identified in two RCCs from the same patient confirming their distinct origin.Taken together, these results firmly support a three step model for tumorigenesis in this family. A constitutional translocation t(1q;3q) increased the susceptibility to loss of the derivative chromosome 3 which is then followed by somatic mutations of the RCC related tumour suppressor gene VHL located in the remaining copy of chromosome 3.


Keywords: familial renal cell carcinoma; translocation; von Hippel-Lindau disease; loss of heterozygosity PMID:11238683

  11. Q c and Q S wave attenuation of South African earthquakes

    NASA Astrophysics Data System (ADS)

    Brandt, Martin B. C.

    2016-04-01

    Quality factor Q, which describes the attenuation of seismic waves with distance, was determined for South Africa using data recorded by the South African National Seismograph Network. Because of an objective paucity of seismicity in South Africa and modernisation of the seismograph network only in 2007, I carried out a coda wave decay analysis on only 13 tectonic earthquakes and 7 mine-related events for the magnitude range 3.6 ≤ M L ≤ 4.4. Up to five seismograph stations were utilised to determine Q c for frequencies at 2, 4, 8 and 16 Hz resulting in 84 individual measurements. The constants Q 0 and α were determined for the attenuation relation Q c( f) = Q 0 f α . The result was Q 0 = 396 ± 29 and α = 0.72 ± 0.04 for a lapse time of 1.9*( t s - t 0) (time from origin time t 0 to the start of coda analysis window is 1.9 times the S-travel time, t s) and a coda window length of 80 s. This lapse time and coda window length were found to fit the most individual frequencies for a signal-to-noise ratio of at least 3 and a minimum absolute correlation coefficient for the envelope of 0.5. For a positive correlation coefficient, the envelope amplitude increases with time and Q c was not calculated. The derived Q c was verified using the spectral ratio method on a smaller data set consisting of nine earthquakes and one mine-related event recorded by up to four seismograph stations. Since the spectral ratio method requires absolute amplitudes in its calculations, site response tests were performed to select four appropriate stations without soil amplification and/or signal distortion. The result obtained for Q S was Q 0 = 391 ± 130 and α = 0.60 ± 0.16, which agrees well with the coda Q c result.

  12. A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome

    PubMed Central

    Frohlich, Joel; Senturk, Damla; Saravanapandian, Vidya; Golshani, Peyman; Reiter, Lawrence T.; Sankar, Raman; Thibert, Ronald L.; DiStefano, Charlotte; Huberty, Scott; Cook, Edwin H.; Jeste, Shafali S.

    2016-01-01

    Background Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked whether EEG power in the beta band, as well as in other frequency bands, distinguished children with Dup15q syndrome from those with non-syndromic ASD and then examined the clinical correlates of this electrophysiological biomarker in Dup15q syndrome. Methods In the first study, we recorded spontaneous EEG from children with Dup15q syndrome (n = 11), age-and-IQ-matched children with ASD (n = 10) and age-matched typically developing (TD) children (n = 9) and computed relative power in 6 frequency bands for 9 regions of interest (ROIs). Group comparisons were made using a repeated measures analysis of variance. In the second study, we recorded spontaneous EEG from a larger cohort of individuals with Dup15q syndrome (n = 27) across two sites and examined age, epilepsy, and duplication type as predictors of beta power using simple linear regressions. Results In the first study, spontaneous beta1 (12–20 Hz) and beta2 (20–30 Hz) power were significantly higher in Dup15q syndrome compared with both comparison groups, while delta (1–4 Hz) was significantly lower than both comparison groups. Effect sizes in all three frequency bands were large (|d| > 1). In the second study, we found that beta2 power was significantly related to epilepsy diagnosis in Dup15q syndrome. Conclusions Here, we have identified an electrophysiological biomarker of Dup15q syndrome that may facilitate clinical stratification, treatment monitoring, and measurement of target engagement for future clinical trials. Future work will investigate the genetic and neural underpinnings of this electrophysiological signature as well as the functional consequences of excessive beta oscillations in Dup15q syndrome. PMID:27977700

  13. Holoprosencephaly with cerebellar vermis hypoplasia in 13q deletion syndrome: Critical region for cerebellar dysgenesis within 13q32.2q34.

    PubMed

    Mimaki, Masakazu; Shiihara, Takashi; Watanabe, Mio; Hirakata, Kyoko; Sakazume, Satoru; Ishiguro, Akio; Shimojima, Keiko; Yamamoto, Toshiyuki; Oka, Akira; Mizuguchi, Masashi

    2015-08-01

    We describe two unrelated patients with terminal deletions in the long arm of chromosome 13 showing brain malformation consisting of holoprosencephaly and cerebellar vermis hypoplasia. Array comparative genomic hybridization analysis revealed a pure terminal deletion of 13q31.3q34 in one patient and a mosaic ring chromosome with 13q32.2q34 deletion in the other. Mutations in ZIC2, located within region 13q32, cause holoprosencephaly, whereas the 13q32.2q32.3 region is associated with cerebellar vermis hypoplasia (Dandy-Walker syndrome). The rare concurrence of these major brain malformations in our patients provides further evidence that 13q32.2q32.3 deletion, harboring ZIC2 and ZIC5, leads to cerebellar dysgenesis.

  14. Chromosome 11q13 deletion syndrome

    PubMed Central

    Kim, Yu-Seon; Kim, Gun-Ha; Byeon, Jung Hye; Eun, So-Hee

    2016-01-01

    Chromosome 11q13 deletion syndrome has been previously reported as either otodental syndrome or oculo-oto-dental syndrome. The otodental syndrome is characterized by dental abnormalities and high-frequency sensorineural hearing loss, and by ocular coloboma in some cases. The underlying genetic defect causing otodental syndrome is a hemizygous microdeletion involving the FGF3 gene on chromosome 11q13.3. Recently, a new form of severe deafness, microtia (small ear) and small teeth, without the appearance of eye abnormalities, was also reported. In this report, we describe a 1-year-old girl presenting with ptosis of the left upper eyelid, right auricular deformity, high-arched palate, delayed dentition, simian line on the right hand, microcephaly, and developmental delay. In this patient, we identified a deletion in the chromosome 11q13.2-q13.3 (2.75 Mb) region by using an array-comparative genomic hybridization analysis. The deletion in chromosome 11q13 results in a syndrome characterized by variable clinical manifestations. Some of these manifestations involve craniofacial dysmorphology and require a functional workup for hearing, ophthalmic examinations, and long-term dental care. PMID:28018436

  15. k and q Dedicated to Paul Callaghan

    NASA Astrophysics Data System (ADS)

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion.

  16. Q-Thruster Breadboard Campaign Project

    NASA Technical Reports Server (NTRS)

    White, Harold

    2014-01-01

    Dr. Harold "Sonny" White has developed the physics theory basis for utilizing the quantum vacuum to produce thrust. The engineering implementation of the theory is known as Q-thrusters. During FY13, three test campaigns were conducted that conclusively demonstrated tangible evidence of Q-thruster physics with measurable thrust bringing the TRL up from TRL 2 to early TRL 3. This project will continue with the development of the technology to a breadboard level by leveraging the most recent NASA/industry test hardware. This project will replace the manual tuning process used in the 2013 test campaign with an automated Radio Frequency (RF) Phase Lock Loop system (precursor to flight-like implementation), and will redesign the signal ports to minimize RF leakage (improves efficiency). This project will build on the 2013 test campaign using the above improvements on the test implementation to get ready for subsequent Independent Verification and Validation testing at Glenn Research Center (GRC) and Jet Propulsion Laboratory (JPL) in FY 2015. Q-thruster technology has a much higher thrust to power than current forms of electric propulsion (7x Hall thrusters), and can significantly reduce the total power required for either Solar Electric Propulsion (SEP) or Nuclear Electric Propulsion (NEP). Also, due to the high thrust and high specific impulse, Q-thruster technology will greatly relax the specific mass requirements for in-space nuclear reactor systems. Q-thrusters can reduce transit times for a power-constrained architecture.

  17. Q-FANSTM for general aviation aircraft

    NASA Technical Reports Server (NTRS)

    Worobel, R.; Mayo, M. G.

    1973-01-01

    Continued growth of general aviation over the next 10 to 15 years is dependent on continuing improvement in aircraft safety, utility, performance and cost. Moreover, these advanced aircraft will need to conform to expected government regulations controlling propulsion system emissions and noise levels. An attractive compact low noise propulsor concept, the Q-FANTM when matched to piston, rotary combustion, or gas turbine engines opens up the exciting prospect of new, cleaner airframe designs for the next generation of general aviation aircraft which will provide these improvements and meet the expected noise and pollution restriction of the 1980 time period. New Q-FAN methodology which was derived to predict Q-FAN noise, weight and cost is presented. Based on this methodology Q-FAN propulsion system performance, weight, noise, and cost trends are discussed. Then the impact of this propulsion system type on the complete aircraft is investigated for several representative aircraft size categories. Finally, example conceptual designs for Q-FAN/engine integration and aircraft installations are presented.

  18. k and q Dedicated to Paul Callaghan.

    PubMed

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Holographic superconductor on Q-lattice

    NASA Astrophysics Data System (ADS)

    Ling, Yi; Liu, Peng; Niu, Chao; Wu, Jian-Pin; Xian, Zhuo-Yu

    2015-02-01

    We construct the simplest gravitational dual model of a superconductor on Q-lattices. We analyze the condition for the existence of a critical temperature at which the charged scalar field will condense. In contrast to the holographic superconductor on ionic lattices, the presence of Q-lattices will suppress the condensate of the scalar field and lower the critical temperature. In particular, when the Q-lattice background is dual to a deep insulating phase, the condensation would never occur for some small charges. Furthermore, we numerically compute the optical conductivity in the superconducting regime. It turns out that the presence of Q-lattice does not remove the pole in the imaginary part of the conductivity, ensuring the appearance of a delta function in the real part. We also evaluate the gap which in general depends on the charge of the scalar field as well as the Q-lattice parameters. Nevertheless, when the charge of the scalar field is relatively large and approaches the probe limit, the gap becomes universal with ω g ≃ 9 T c which is consistent with the result for conventional holographic superconductors.

  20. High-Q AlN/SiO2 symmetric composite thin film bulk acoustic wave resonators.

    PubMed

    Artieda, Alvaro; Muralt, Paul

    2008-11-01

    High-Q, bulk acoustic wave composite resonators based on a symmetric layer sequence of SiO(2)-AlN-SiO(2) sandwiched between electrodes have been developed. Acoustic isolation was achieved by means of deep silicon etching to obtain membrane type thin film bulk acoustic wave resonators (TFBARs). Three different device versions were investigated. The SiO(2) film thicknesses were varied (0 nm, 70 nm, 310 nm, and 770 nm) while the piezoelectric AlN film had a constant thickness of 1.2 microm. The sputter-deposited AlN film grown on the amorphous, sputter-deposited SiO(2) layer exhibited a d(33,f) of 4.0 pm/V. Experimental results of quality factors (Q) and coupling coefficients (k(t)(2)) are in agreement with finite element calculations. A Q of 2000 is observed for the first harmonic of the 310 nm oxide devices. The most intense resonance of the 770 nm oxide device is the third harmonic reaching Q factors of 1450. The temperature drift reveals the impact of the SiO(2) layers, which is more pronounced on the first harmonic, reducing the TCF to 4 ppm/K for the 3rd harmonic of the 310 nm oxide devices.

  1. Characterization of a balanced reciprocal translocation, rcp(9;11)(q27;q11) in cattle.

    PubMed

    De Lorenzi, L; De Giovanni, A; Molteni, L; Denis, C; Eggen, A; Parma, P

    2007-01-01

    Cytogenetic analysis of a phenotypically normal young bull from Marchigiana breed revealed the presence of an abnormal karyotype. The observation of longer and smaller chromosomes than BTA1 and BTA29, respectively in all metaphases suggested the presence of a reciprocal translocation. RBG-banding confirmed this hypothesis revealing the involvement of BTA9 and BTA11. FISH analyses using cattle-specific BAC clones (474A12 and 293G09 for BTA9; 035D03 for BTA11) identified rcp(9;11)(q27;q11) in the two regions affected. Moreover analyses performed on both parents established the 'de novo' origin of the anomaly. Comparison with human homologue sequences (HSA6q24.3-->q25.3 for BTA9q27 and HSA2q11.1-->q12.1 for BTA11q11) revealed that both breakpoint regions are gene rich as up to date at least 200 genes have been localized in these regions. Thus, further analyses are required to identify the sequences disrupted by the breakpoints and to verify their consequences on rcp carrier phenotype. Copyright (c) 2008 S. Karger AG, Basel.

  2. Recurrent spontaneous abortions due to a homologous Robertsonian translocation (14q14q)

    PubMed Central

    Gracias-Espinal, R; Roberts, S H; Duckett, D P; Laurence, K M

    1982-01-01

    A female with a history of recurrent spontaneous abortions was shown to carry a balanced Robertsonian translocation involving the No 14 homologues. One abortus had trisomy 14 with a 46,XX,-14,+t(14q14q)mat karyotype. Images PMID:7154046

  3. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis.

    PubMed

    Jackson, A; Carrara, P; Duke, V; Sinclair, P; Papaioannou, M; Harrison, C J; Foroni, L

    2000-06-01

    Two distinct regions of minimal deletion (RMD) have been identified at 6q25-q27 in non-Hodgkin's lymphoma (RMD-1), and at 6q21-q23 in acute lymphoblastic leukemia (ALL; RMD-2) by loss of heterozygosity and fluorescence in situ hybridization studies. In this study, 30 overlapping yeast artificial chromosomes (YACs), 1 expressed sequence tag, and 11 novel YAC ends were identified using bidirectional YAC walks between markers D6S447 (proximal) and D6S246 (distal) in RMD-2. The genes AF6q21, human homologue of the Drosophila tailless (HTLX), CD24 antigen, the Kruppel-like zinc finger BLIMP1, and cyclin C (CCNC), previously mapped to 6q21, were accurately positioned in a telomere-to-centromere orientation. Approximately 3.5 Mb were found to separate the BLIMP1 (adjacent to D6S447) and AF6q21 genes (telomeric to D6S246). Deletions of 6q were investigated in 21 cases of ALL using the newly characterized YAC clones in dual-color fluorescence in situ hybridization studies. A region centromeric to D6S447 (containing marker D6S283) and a region telomeric to marker CHLC.GGAT16CO2 (and containing marker D6S268) were identified as distinct and nonoverlapping regions of deletion in ALL.

  4. Even–odd layer-dependent magnetotransport of high-mobility Q-valley electrons in transition metal disulfides

    PubMed Central

    Wu, Zefei; Xu, Shuigang; Lu, Huanhuan; Khamoshi, Armin; Liu, Gui-Bin; Han, Tianyi; Wu, Yingying; Lin, Jiangxiazi; Long, Gen; He, Yuheng; Cai, Yuan; Yao, Yugui; Zhang, Fan; Wang, Ning

    2016-01-01

    In few-layer transition metal dichalcogenides (TMDCs), the conduction bands along the ΓK directions shift downward energetically in the presence of interlayer interactions, forming six Q valleys related by threefold rotational symmetry and time reversal symmetry. In even layers, the extra inversion symmetry requires all states to be Kramers degenerate; whereas in odd layers, the intrinsic inversion asymmetry dictates the Q valleys to be spin-valley coupled. Here we report the transport characterization of prominent Shubnikov-de Hass (SdH) oscillations and the observation of the onset of quantum Hall plateaus for the Q-valley electrons in few-layer TMDCs. Universally in the SdH oscillations, we observe a valley Zeeman effect in all odd-layer TMDC devices and a spin Zeeman effect in all even-layer TMDC devices, which provide a crucial information for understanding the unique properties of multi-valley band structures of few-layer TMDCs. PMID:27651106

  5. Even-odd layer-dependent magnetotransport of high-mobility Q-valley electrons in transition metal disulfides

    NASA Astrophysics Data System (ADS)

    Wu, Zefei; Xu, Shuigang; Lu, Huanhuan; Khamoshi, Armin; Liu, Gui-Bin; Han, Tianyi; Wu, Yingying; Lin, Jiangxiazi; Long, Gen; He, Yuheng; Cai, Yuan; Yao, Yugui; Zhang, Fan; Wang, Ning

    2016-09-01

    In few-layer transition metal dichalcogenides (TMDCs), the conduction bands along the ΓK directions shift downward energetically in the presence of interlayer interactions, forming six Q valleys related by threefold rotational symmetry and time reversal symmetry. In even layers, the extra inversion symmetry requires all states to be Kramers degenerate; whereas in odd layers, the intrinsic inversion asymmetry dictates the Q valleys to be spin-valley coupled. Here we report the transport characterization of prominent Shubnikov-de Hass (SdH) oscillations and the observation of the onset of quantum Hall plateaus for the Q-valley electrons in few-layer TMDCs. Universally in the SdH oscillations, we observe a valley Zeeman effect in all odd-layer TMDC devices and a spin Zeeman effect in all even-layer TMDC devices, which provide a crucial information for understanding the unique properties of multi-valley band structures of few-layer TMDCs.

  6. Automatic determination of coenzyme Q10 in food using cresyl violet encapsulated into magnetoliposomes.

    PubMed

    Román-Pizarro, Vanessa; Fernández-Romero, Juan Manuel; Gómez-Hens, Agustina

    2017-04-15

    A new type of magnetoliposomes (MLs), containing hydrophobic magnetic-gold nanoparticles and the long wavelength fluorophore cresyl violet, has been used for the determination of coenzyme Q10 (CoQ10). MLs were concentrated just before the detector, using a flow system and an external electromagnet device. The subsequent introduction of Triton X-100 and CoQ10 causes the MLs lysis and the cresyl violet oxidation, obtaining a decrease in the fluorescence signal. The dynamic range of the calibration graph was 0.03-0.50μmolL(-1) CoQ10, and the detection limit was 0.008μmolL(-1). The precision (relative standard deviation) was in the range of 1.3-4.5%. The method showed a sampling frequency of 12h(-1) and was applied to the determination of CoQ10 in several food samples. The results were compared with those obtained using a previously described chromatographic method. Also, recovery values were in the range of 83.5-101.3%.

  7. [Difficult airway management using the air-Q in a patient with Klippel-Feil syndrome].

    PubMed

    Komasawa, Nobuyasu; Miyazaki, Shinichiro; Soen, Masako; Kusunoki, Tomohiro; Tatsumi, Shinichi; Minami, Toshiaki

    2014-06-01

    Patients with Klippel-Feil syndrome (KFS) frequently encounter difficult airway management due to skeletal abnormalities, including fusion of two or more vertebrae and short neck. We report successful tracheal intubation using the air-Q supraglottic airway device (air-Q). A 46-year-old woman (height, 149 cm; weight, 62 kg) with KFS was scheduled to undergo vertebral arch plasty for cervical spondylotic myelopathy. She could open her mouth sufficiently but could not tilt her head due to C1-3 fusion. Following administration of fentanyl 100 microg and propofol 120 mg, mask ventilation was achieved with jaw thrust maneuver. We then administered rocuronium 50 mg for immobilization and attempted tracheal intubation using the Pentax-AWS Airwayscope with a thin pediatric Intlock. However, we could not target the glottis, and ventilation via a size 3 i-gel or size 3.5 air-Q was unsuccessful. Using a size 2.5 air-Q, sufficient ventilation was finally achieved. We performed fiberoptic tracheal intubation through the air-Q using a tube with an internal diameter of 6.0-mm. We then exchanged the 6.0-mm tracheal tube with a 7.0-mm spiral tube using a 10 Fr tracheal tube introducer.

  8. Passive Q Switching of a Solar-Pumped Nd:YAG Laser

    NASA Astrophysics Data System (ADS)

    Lando, Mordechai; Shimony, Yehoshua; Noter, Yoram; Benmair, Roth M. J.; Yogev, Amnon

    2000-04-01

    Passive Q switching is a preferable choice for switching the Q factor of a solar-pumped laser because it requires neither a driver nor an electrical power supply. The superior thermal characteristics and durability of Cr 4 :YAG single crystals as passive Q switches for lamp and diode-pumped high-power lasers has been demonstrated. Here we report on an average power of 37 W and a switching efficiency of 80% obtained by use of a solar-pumped Nd:YAG laser Q switched by a Cr 4 :YAG saturable absorber. Concentration of the pumping solar energy on the laser crystal was obtained with a three-stage concentrator, composed of 12 heliostats, a three-dimensional compound parabolic concentrator (CPC) and a two-dimensional CPC. The water-cooled passive Q switch also served as the laser rear mirror. Repetition rates of as much as 50 kHz, at pulse durations between 190 and 310 ns (FWHM) were achieved. From the experimental results, the saturated single-pass power absorption of the Cr 4 :YAG device was estimated as 3 1%.

  9. Wind in November, Q Fever in December

    PubMed Central

    Tissot-Dupont, Hervé; Amadei, Marie-Antoinette; Nezri, Meyer

    2004-01-01

    Q fever, a worldwide zoonosis caused by Coxiella burnetii, can be transmitted from animal reservoirs to humans by the inhalation of infected aerosols. We investigated the epidemiology of Q fever in the Bouches-du-Rhone district of southern France, particularly the role of wind and rainfall in C. burnetii transmission. During the winter of 1998 to 1999, an unexpected number of cases were diagnosed in the area. This statistically higher incidence was associated with an increased frequency of the mistral 1 month before onset of disease, i.e., shortly after the main lambing season. These data confirm that wind plays a role in C. burnetii transmission, a factor that can be monitored but not prevented. Further studies are needed to identify and confirm preventable individual behavioral risk factors for Q fever. PMID:15324547

  10. Superconductivity devices: Commercial use of space

    NASA Technical Reports Server (NTRS)

    Haertling, Gene; Hsi, Chi-Shiung; Mcintyre, Ladawn; Li, Guang

    1992-01-01

    The high T(sub c) superconducting ceramic materials, developed in 1987, are now being extensively investigated for a variety of engineering applications. These applications include such devices as conducting links, rotating and linear bearings, sensors, filters, switches, high Q cavities, magnets, and motors. Some of these devices take advantage of the material's ability to lose all electrical resistance at a critical temperature, T(sub c), while others make use of the repulsion forces generated between the magnetic field of a permanent magnet and a superconductor which is cooled below its T(sub c), Meissner effect. This report describes the work accomplished to date by: (1) reviewing the present state of the art in actuator technology, (2) evaluating processing and fabrication of high strain electrostrictive materials, and (3) testing these electrostrictive materials.

  11. Exploring Carbon Nanotubes for Nanoscale Devices

    NASA Technical Reports Server (NTRS)

    Han, Jie; Dai; Anantram; Jaffe; Saini, Subhash (Technical Monitor)

    1998-01-01

    Carbon nanotubes (CNTs) are shown to promise great opportunities in nanoelectronic devices and nanoelectromechanical systems (NEMS) because of their inherent nanoscale sizes, intrinsic electric conductivities, and seamless hexagonal network architectures. I present our collaborative work with Stanford on exploring CNTs for nanodevices in this talk. The electrical property measurements suggest that metallic tubes are quantum wires. Furthermore, two and three terminal CNT junctions have been observed experimentally. We have proposed and studied CNT-based molecular switches and logic devices for future digital electronics. We also have studied CNTs based NEMS inclusing gears, cantilevers, and scanning probe microscopy tips. We investigate both chemistry and physics based aspects of the CNT NEMS. Our results suggest that CNT have ideal stiffness, vibrational frequencies, Q-factors, geometry-dependent electric conductivities, and the highest chemical and mechanical stabilities for the NEMS. The use of CNT SPM tips for nanolithography is presented for demonstration of the advantages of the CNT NEMS.

  12. A new deletion of 18q23 with few typical features of the 18q- syndrome.

    PubMed Central

    Kohonen-Corish, M; Strathdee, G; Overhauser, J; McDonald, T; Jammu, V

    1996-01-01

    We report on a patient with a deletion of 18q23. At both 2 and 4 years of age, she displayed few of the facial features or other clinical features associated with the 18q- syndrome. Fluorescent in situ hybridisation and microsatellite marker and RFLP analysis were performed to characterise the extent of the deletion, and a terminal deletion of 18q23 was confirmed. The deleted region includes the gene for myelin basic protein, suggesting that hemizygosity of this gene does not invariably lead to mental and developmental delay. The clinical presentation of this patient suggests that either she is not deleted for the genes involved in the 18q- clinical phenotype or this patient represents one end of the spectrum of the clinical variability seen with 18q terminal deletions. Images PMID:8728701

  13. RNAs of the human chromsome 15q11-q13 imprinted region

    PubMed Central

    Chamberlain, Stormy J.

    2012-01-01

    The human chromosome 15q11-q13 region hosts a wide variety of coding and non-coding RNAs, and is also the site of nearly every imaginable type of RNA processing. To deepen the intrigue, the transcripts in the human chromosome 15q11-q13 region are subject to regulation by genomic imprinting, and some of these transcripts are imprinted in a tissue-specific manner. Since the region is critically important for three human neurogenetic disorders, Angelman syndrome, Prader-Willi syndrome, and 15q duplication syndrome, there is intense interest in understanding the types of RNA and RNA processing that occurs among the imprinted genes. This review summarizes what is known about the various RNAs within the imprinted domain, including a novel type of RNA that was only very recently identified. PMID:23208756

  14. A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22.

    PubMed

    Dierks, C; Mömke, S; Drögemüller, C; Leeb, T; Chowdhary, B P; Distl, O

    2006-10-01

    In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene-associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12-q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12-q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human-equine comparative map, which allows the identification of candidate genes underlying traits of interest.

  15. Calcium binding and transport by coenzyme Q.

    PubMed

    Bogeski, Ivan; Gulaboski, Rubin; Kappl, Reinhard; Mirceski, Valentin; Stefova, Marina; Petreska, Jasmina; Hoth, Markus

    2011-06-22

    Coenzyme Q10 (CoQ10) is one of the essential components of the mitochondrial electron-transport chain (ETC) with the primary function to transfer electrons along and protons across the inner mitochondrial membrane (IMM). The concomitant proton gradient across the IMM is essential for the process of oxidative phosphorylation and consequently ATP production. Cytochrome P450 (CYP450) monoxygenase enzymes are known to induce structural changes in a variety of compounds and are expressed in the IMM. However, it is unknown if CYP450 interacts with CoQ10 and how such an interaction would affect mitochondrial function. Using voltammetry, UV-vis spectrometry, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), fluorescence microscopy and high performance liquid chromatography-mass spectrometry (HPLC-MS), we show that both CoQ10 and its analogue CoQ1, when exposed to CYP450 or alkaline media, undergo structural changes through a complex reaction pathway and form quinone structures with distinct properties. Hereby, one or both methoxy groups at positions 2 and 3 on the quinone ring are replaced by hydroxyl groups in a time-dependent manner. In comparison with the native forms, the electrochemically reduced forms of the new hydroxylated CoQs have higher antioxidative potential and are also now able to bind and transport Ca(2+) across artificial biomimetic membranes. Our results open new perspectives on the physiological importance of CoQ10 and its analogues, not only as electron and proton transporters, but also as potential regulators of mitochondrial Ca(2+) and redox homeostasis.

  16. Nonclassical Properties of Q-Deformed Superposition Light Field State

    NASA Technical Reports Server (NTRS)

    Ren, Min; Shenggui, Wang; Ma, Aiqun; Jiang, Zhuohong

    1996-01-01

    In this paper, the squeezing effect, the bunching effect and the anti-bunching effect of the superposition light field state which involving q-deformation vacuum state and q-Glauber coherent state are studied, the controllable q-parameter of the squeezing effect, the bunching effect and the anti-bunching effect of q-deformed superposition light field state are obtained.

  17. Smart portable rehabilitation devices.

    PubMed

    Mavroidis, Constantinos; Nikitczuk, Jason; Weinberg, Brian; Danaher, Gil; Jensen, Katherine; Pelletier, Philip; Prugnarola, Jennifer; Stuart, Ryan; Arango, Roberto; Leahey, Matt; Pavone, Robert; Provo, Andrew; Yasevac, Dan

    2005-07-12

    The majority of current portable orthotic devices and rehabilitative braces provide stability, apply precise pressure, or help maintain alignment of the joints with out the capability for real time monitoring of the patient's motions and forces and without the ability for real time adjustments of the applied forces and motions. Improved technology has allowed for advancements where these devices can be designed to apply a form of tension to resist motion of the joint. These devices induce quicker recovery and are more effective at restoring proper biomechanics and improving muscle function. However, their shortcoming is in their inability to be adjusted in real-time, which is the most ideal form of a device for rehabilitation. This introduces a second class of devices beyond passive orthotics. It is comprised of "active" or powered devices, and although more complicated in design, they are definitely the most versatile. An active or powered orthotic, usually employs some type of actuator(s). In this paper we present several new advancements in the area of smart rehabilitation devices that have been developed by the Northeastern University Robotics and Mechatronics Laboratory. They are all compact, wearable and portable devices and boast re-programmable, real time computer controlled functions as the central theme behind their operation. The sensory information and computer control of the three described devices make for highly efficient and versatile systems that represent a whole new breed in wearable rehabilitation devices. Their applications range from active-assistive rehabilitation to resistance exercise and even have applications in gait training. The three devices described are: a transportable continuous passive motion elbow device, a wearable electro-rheological fluid based knee resistance device, and a wearable electrical stimulation and biofeedback knee device. Laboratory tests of the devices demonstrated that they were able to meet their design

  18. Smart portable rehabilitation devices

    PubMed Central

    Mavroidis, Constantinos; Nikitczuk, Jason; Weinberg, Brian; Danaher, Gil; Jensen, Katherine; Pelletier, Philip; Prugnarola, Jennifer; Stuart, Ryan; Arango, Roberto; Leahey, Matt; Pavone, Robert; Provo, Andrew; Yasevac, Dan

    2005-01-01

    Background The majority of current portable orthotic devices and rehabilitative braces provide stability, apply precise pressure, or help maintain alignment of the joints with out the capability for real time monitoring of the patient's motions and forces and without the ability for real time adjustments of the applied forces and motions. Improved technology has allowed for advancements where these devices can be designed to apply a form of tension to resist motion of the joint. These devices induce quicker recovery and are more effective at restoring proper biomechanics and improving muscle function. However, their shortcoming is in their inability to be adjusted in real-time, which is the most ideal form of a device for rehabilitation. This introduces a second class of devices beyond passive orthotics. It is comprised of "active" or powered devices, and although more complicated in design, they are definitely the most versatile. An active or powered orthotic, usually employs some type of actuator(s). Methods In this paper we present several new advancements in the area of smart rehabilitation devices that have been developed by the Northeastern University Robotics and Mechatronics Laboratory. They are all compact, wearable and portable devices and boast re-programmable, real time computer controlled functions as the central theme behind their operation. The sensory information and computer control of the three described devices make for highly efficient and versatile systems that represent a whole new breed in wearable rehabilitation devices. Their applications range from active-assistive rehabilitation to resistance exercise and even have applications in gait training. The three devices described are: a transportable continuous passive motion elbow device, a wearable electro-rheological fluid based knee resistance device, and a wearable electrical stimulation and biofeedback knee device. Results Laboratory tests of the devices demonstrated that they were able to

  19. Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ

    PubMed Central

    2016-01-01

    Recently, a novel pathway for heme b biosynthesis in Gram-positive bacteria has been proposed. The final poorly understood step is catalyzed by an enzyme called HemQ and includes two decarboxylation reactions leading from coproheme to heme b. Coproheme has been suggested to act as both substrate and redox active cofactor in this reaction. In the study presented here, we focus on HemQs from Listeria monocytogenes (LmHemQ) and Staphylococcus aureus (SaHemQ) recombinantly produced as apoproteins in Escherichia coli. We demonstrate the rapid and two-phase uptake of coproheme by both apo forms and the significant differences in thermal stability of the apo forms, coproheme-HemQ and heme b-HemQ. Reduction of ferric high-spin coproheme-HemQ to the ferrous form is shown to be enthalpically favored but entropically disfavored with standard reduction potentials of −205 ± 3 mV for LmHemQ and −207 ± 3 mV for SaHemQ versus the standard hydrogen electrode at pH 7.0. Redox thermodynamics suggests the presence of a pronounced H-bonding network and restricted solvent mobility in the heme cavity. Binding of cyanide to the sixth coproheme position is monophasic but relatively slow (∼1 × 104 M–1 s–1). On the basis of the available structures of apo-HemQ and modeling of both loaded forms, molecular dynamics simulation allowed analysis of the interaction of coproheme and heme b with the protein as well as the role of the flexibility at the proximal heme cavity and the substrate access channel for coproheme binding and heme b release. Obtained data are discussed with respect to the proposed function of HemQ in monoderm bacteria. PMID:27599156

  20. Distinctive Phenotype in 9 Patients with Deletion of Chromosome 1q24-q25

    PubMed Central

    Burkardt, Deepika D’Cunha; Rosenfeld, Jill A.; Helgeson, Maria; Angle, Brad; Banks, Valerie; Smith, Wendy; Gripp, Karen W.; Moline, Jessica; Moran, Rocio; Niyazov, Dmitriy M.; Stevens, Cathy; Zackai, Elaine; Lebel, Robert Roger; Ashley, Douglas; Kramer, Nancy; Lachman, Ralph S.; Graham, John M.

    2011-01-01

    Reports of individuals with deletions of 1q24→q25 share common features of prenatal onset growth deficiency, microcephaly, small hands and feet, dysmorphic face and severe cognitive deficits. We report nine individuals with 1q24q25 deletions, who show distinctive features of a clinically recognizable 1q24q25 microdeletion syndrome: prenatal-onset microcephaly and proportionate growth deficiency, severe cognitive disability, small hands and feet with distinctive brachydactyly, single transverse palmar flexion creases, fifth finger clinodactyly and distinctive facial features: upper eyelid fullness, small ears, short nose with bulbous nasal tip, tented upper lip, and micrognathia. Radiographs demonstrate disharmonic osseous maturation with markedly delayed bone age. Occasional features include cleft lip and/or palate, cryptorchidism, brain and spinal cord defects, and seizures. Using oligonucleotide-based array comparative genomic hybridization, we defined the critical deletion region as 1.9 Mb at 1q24.3q25.1 (chr1: 170135865–172099327, hg18 coordinates), containing 13 genes and including CENPL, which encodes centromeric protein L, a protein essential for proper kinetochore function and mitotic progression. The growth deficiency in this syndrome is similar to what is seen in other types of primordial short stature with microcephaly, such as Majewski osteodysplastic primordial dwarfism, type II (MOPD2) and Seckel syndrome, which result from loss-of-function mutations in genes coding for centrosomal proteins. DNM3 is also in the deleted region and expressed in the brain, where it participates in the Shank-Homer complex and increases synaptic strength. Therefore, DNM3 is a candidate for the cognitive disability, and CENPL is a candidate for growth deficiency in this 1q24q25 microdeletion syndrome. PMID:21548129

  1. Q-Balls with Scalar Charge

    NASA Astrophysics Data System (ADS)

    Levin, A.; Rubakov, V.

    We consider Friedberg-Lee-Sirlin Q-balls in a (3+1)-dimensional model with vanishing scalar potential of one of the fields. We show that, unlike in (2+1) and (1+1) dimensions, the Q-ball is stabilized by the gradient energy of this field and carries scalar charge, over and beyond the global charge. The latter property is also inherent in a model with the scalar potential that does not vanish in a finite field region near the origin.

  2. q-Virasoro constraints in matrix models

    NASA Astrophysics Data System (ADS)

    Nedelin, Anton; Zabzine, Maxim

    2017-03-01

    The Virasoro constraints play the important role in the study of matrix models and in understanding of the relation between matrix models and CFTs. Recently the localization calculations in supersymmetric gauge theories produced new families of matrix models and we have very limited knowledge about these matrix models. We concentrate on elliptic generalization of hermitian matrix model which corresponds to calculation of partition function on S 3 × S 1 for vector multiplet. We derive the q-Virasoro constraints for this matrix model. We also observe some interesting algebraic properties of the q-Virasoro algebra.

  3. Q-switched laser prelase detection circuit

    NASA Technical Reports Server (NTRS)

    Lockard, George E.

    1991-01-01

    A compact electronic circuit was developed to detect prelasing in Q-swithed pulsed laser systems and once detected to shut down the laser before the next laser pulse occurs. The circuit is small, compact, and uses a minimum of components which makes it quite economical, thus readily lending itself to commercial applications. It can easily be incorporated into virtually any Q-switched laser system or reliability of a laser system by reducing a source of possible costly optical damage. The circuit operation and instrument requirements necessary to incorporate the circuit into a laser system are discussed.

  4. HYDRAULIC CONDUCTIVITY OF SALTSTONE FORMULATED USING 1Q11, 2Q11 AND 3Q11 TANK 50 SLURRY SAMPLES

    SciTech Connect

    Reigel, M.; Nichols, R.

    2012-06-27

    As part of the Saltstone formulation work requested by Waste Solidification Engineering (WSE), Savannah River National Laboratory (SRNL) was tasked with preparing Saltstone samples for fresh property analysis and hydraulic conductivity measurements using actual Tank 50 salt solution rather than simulated salt solution. Samples of low level waste salt solution collected from Tank 50H during the first, second, and third quarters of 2011 were used to formulate the Saltstone samples. The salt solution was mixed with premix (45 wt % slag, 45 wt % fly ash, and 10 wt % cement), in a ratio consistent with facility operating conditions during the quarter of interest. The fresh properties (gel, set, bleed) of each mix were evaluated and compared to the recommended acceptance criteria for the Saltstone Production Facility. ASTM D5084-03, Method C was used to measure the hydraulic conductivity of the Saltstone samples. The hydraulic conductivity of Saltstone samples prepared from 1Q11 and 2Q11 samples of Tank 50H is 4.2E-9 cm/sec and 2.6E-9 cm/sec, respectively. Two additional 2Q11 and one 3Q11 sample were not successfully tested due to the inability to achieve stable readings during saturation and testing. The hydraulic conductivity of the samples made from Tank 50H salt solution compare well to samples prepared with simulated salt solution and cured under similar conditions (1.4E-9 - 4.9E-8 cm/sec).

  5. Use of the On-Q Pain Pump in Alveolar Bone Grafting: Effect on Hospital Length of Stay.

    PubMed

    Muzaffar, Arshad R; Warren, Abby; Baker, C Lynette

    2016-03-01

    Alveolar bone grafting (ABG) with iliac crest bone graft can be associated with significant pain at the donor site. The On-Q pain pump has been shown to be efficacious in treating postsurgical pain. The aim of this study was to compare the length of postoperative hospital stay in patients undergoing ABG who received the On-Q pain pump at the iliac crest donor site (On-Q+) with that of patients who did not receive the On-Q pain pump (On-Q-). A retrospective, cohort study, approved by institutional review board, was performed. Thirty-one consecutive patients in the On-Q- group were compared with 38 consecutive patients in the On-Q+ group. The two cohorts were assessed for length of stay. Statistical analysis was performed using the Fisher exact probability test. Tertiary care academic medical center. Sixty-nine patients with cleft lip and/or cleft palate (CL/P) undergoing secondary ABG with iliac crest bone graft were operated on between May 1993 and January 2014. Length of postoperative hospital stay. Mean length of stay in the On-Q- patients was 0.52 days versus 0.37 days for the On-Q+ patients. This difference between the two cohorts was not statistically significant (P = .234). Although there is a trend toward a shorter length of stay in our patients who received the On-Q pump, this finding was not statistically significant. Given the expense and additional burden of care associated with the device, we have become more selective in its utilization.

  6. Stretchable Organic Semiconductor Devices.

    PubMed

    Qian, Yan; Zhang, Xinwen; Xie, Linghai; Qi, Dianpeng; Chandran, Bevita K; Chen, Xiaodong; Huang, Wei

    2016-11-01

    Stretchable electronics are essential for the development of intensely packed collapsible and portable electronics, wearable electronics, epidermal and bioimplanted electronics, 3D surface compliable devices, bionics, prosthesis, and robotics. However, most stretchable devices are currently based on inorganic electronics, whose high cost of fabrication and limited processing area make it difficult to produce inexpensive, large-area devices. Therefore, organic stretchable electronics are highly attractive due to many advantages over their inorganic counterparts, such as their light weight, flexibility, low cost and large-area solution-processing, the reproducible semiconductor resources, and the easy tuning of their properties via molecular tailoring. Among them, stretchable organic semiconductor devices have become a hot and fast-growing research field, in which great advances have been made in recent years. These fantastic advances are summarized here, focusing on stretchable organic field-effect transistors, light-emitting devices, solar cells, and memory devices.

  7. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in Autism Spectrum Disorder Brazilian Individuals with and without Epilepsy

    PubMed Central

    Moreira, Danielle P.; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L.; Lourenço, Naila C. V.; Takahashi, Vanessa N. O.; da Rocha, Kátia M.; Moreira, Eloisa S.; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; Halloran, Eoghan O’; Magalhães, Tiago R.; Fett-Conte, Agnes C.; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy. PMID:25255310

  8. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy.

    PubMed

    Moreira, Danielle P; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L; Lourenço, Naila C V; Takahashi, Vanessa N O; da Rocha, Kátia M; Moreira, Eloisa S; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; O'Halloran, Eoghan; Magalhães, Tiago R; Fett-Conte, Agnes C; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy.

  9. Fuzzy Q-Learning for Generalization of Reinforcement Learning

    NASA Technical Reports Server (NTRS)

    Berenji, Hamid R.

    1996-01-01

    Fuzzy Q-Learning, introduced earlier by the author, is an extension of Q-Learning into fuzzy environments. GARIC is a methodology for fuzzy reinforcement learning. In this paper, we introduce GARIC-Q, a new method for doing incremental Dynamic Programming using a society of intelligent agents which are controlled at the top level by Fuzzy Q-Learning and at the local level, each agent learns and operates based on GARIC. GARIC-Q improves the speed and applicability of Fuzzy Q-Learning through generalization of input space by using fuzzy rules and bridges the gap between Q-Learning and rule based intelligent systems.

  10. Fuzzy Q-Learning for Generalization of Reinforcement Learning

    NASA Technical Reports Server (NTRS)

    Berenji, Hamid R.

    1996-01-01

    Fuzzy Q-Learning, introduced earlier by the author, is an extension of Q-Learning into fuzzy environments. GARIC is a methodology for fuzzy reinforcement learning. In this paper, we introduce GARIC-Q, a new method for doing incremental Dynamic Programming using a society of intelligent agents which are controlled at the top level by Fuzzy Q-Learning and at the local level, each agent learns and operates based on GARIC. GARIC-Q improves the speed and applicability of Fuzzy Q-Learning through generalization of input space by using fuzzy rules and bridges the gap between Q-Learning and rule based intelligent systems.

  11. Sensor sentinel computing device

    DOEpatents

    Damico, Joseph P.

    2016-08-02

    Technologies pertaining to authenticating data output by sensors in an industrial environment are described herein. A sensor sentinel computing device receives time-series data from a sensor by way of a wireline connection. The sensor sentinel computing device generates a validation signal that is a function of the time-series signal. The sensor sentinel computing device then transmits the validation signal to a programmable logic controller in the industrial environment.

  12. Barrier breaching device

    DOEpatents

    Honodel, C.A.

    1983-06-01

    A barrier breaching device that is designed primarily for opening holes in interior walls of buildings uses detonating fuse for explosive force. The fuse acts as the ribs or spokes of an umbrella-like device that may be opened up to form a cone. The cone is placed against the wall so that detonating fuse that rings the base of the device and which is ignited by the spoke-like fuses serves to cut a circular hole in the wall.

  13. Barrier breaching device

    DOEpatents

    Honodel, Charles A.

    1985-01-01

    A barrier breaching device that is designed primarily for opening holes in interior walls of buildings uses detonating fuse for explosive force. The fuse acts as the ribs or spokes of an umbrella-like device that may be opened up to form a cone. The cone is placed against the wall so that detonating fuse that rings the base of the device and which is ignited by the spoke-like fuses serves to cut a circular hole in the wall.

  14. Current state of coenzyme Q(10) production and its applications.

    PubMed

    Jeya, Marimuthu; Moon, Hee-Jung; Lee, Jeong-Lim; Kim, In-Won; Lee, Jung-Kul

    2010-02-01

    Coenzyme Q(10) (CoQ(10)), an obligatory cofactor in the aerobic respiratory electron transfer for energy generation, is formed from the conjugation of a benzoquinone ring with a hydrophobic isoprenoid chain. CoQ(10) is now used as a nutritional supplement because of its antioxidant properties and is beneficial in the treatment of several human diseases when administered orally. Bioprocesses have been developed for the commercial production of CoQ(10) because of its increased demand, and these bioprocesses depend on microbes that produce high levels of CoQ(10) naturally. However, as knowledge of the biosynthetic enzymes and the regulatory mechanisms modulating CoQ(10) production increases, approaches arise for the genetic engineering of CoQ(10) production in Escherichia coli and Agrobacterium tumefaciens. This review focused on approaches for CoQ(10) production, strategies used to engineer CoQ(10) production in microbes, and potential applications of CoQ(10).

  15. Ion trap device

    DOEpatents

    Ibrahim, Yehia M.; Smith, Richard D.

    2016-01-26

    An ion trap device is disclosed. The device includes a series of electrodes that define an ion flow path. A radio frequency (RF) field is applied to the series of electrodes such that each electrode is phase shifted approximately 180 degrees from an adjacent electrode. A DC voltage is superimposed with the RF field to create a DC gradient to drive ions in the direction of the gradient. A second RF field or DC voltage is applied to selectively trap and release the ions from the device. Further, the device may be gridless and utilized at high pressure.

  16. [New Medical Device Evaluation].

    PubMed

    Ikeda, Koji

    2016-01-01

    In this presentation, as a member of the Harmonization by Doing (HBD) project, I discuss the significance of regulatory science in global medical device development and our experience in the international collaboration process for medical devices. In Japan, most innovative medical therapeutic devices were previously developed and exported by foreign-based companies. Due to this device lag, Japanese had minimal opportunities for receiving treatment with innovative medical devices. To address this issue, the Japanese government has actively accepted foreign clinical trial results and promoted global clinical trials in projects such as HBD. HBD is a project with stakeholders from academia, regulatory authorities, and industry in the US and Japan to promote global clinical trials and reduce device lags. When the project started, medical device clinical trials were not actively conducted in Japan at not just hospitals but also at medical device companies. We started to identify issues under the concept of HBD. After 10 years, we have now become key members in global clinical trials and able to obtain approvals without delay. Recently, HBD has started promoting international convergence. Physicians and regulatory authorities play central roles in compiling guidelines for the clinical evaluation of medical device development, which will be a more active field in the near future. The guidelines compiled will be confirmed with members of academia and regulatory authorities in the United Sates.

  17. New unorthodox semiconductor devices

    NASA Astrophysics Data System (ADS)

    Board, K.

    1985-12-01

    A range of new semiconductor devices, including a number of structures which rely entirely upon new phenomena, are discussed. Unipolar two-terminal devices, including impurity-controlled barriers and graded composition barriers, are considered, as are new transistor structures, including the hot-electron camel transistor, the planar-doped barrier transistor, the thermionic emission transistor, and the permeable base transistor. Regenerative switching devices are addressed, including the metal-tunnel insulator-semiconductor switch, the polysilicon switch, MIS, and MISIM switching structures, and the triangular-barrier switch. Heterostructure devices are covered, including the heterojunction bipolar transistor, the selectively doped heterojunction transistor, heterojunction lasers, and quantum-well structures.

  18. Interconnected semiconductor devices

    DOEpatents

    Grimmer, Derrick P.; Paulson, Kenneth R.; Gilbert, James R.

    1990-10-23

    Semiconductor layer and conductive layer formed on a flexible substrate, divided into individual devices and interconnected with one another in series by interconnection layers and penetrating terminals.

  19. Simple piezoelectric translation device

    NASA Astrophysics Data System (ADS)

    Niedermann, Ph.; Emch, R.; Descouts, P.

    1988-02-01

    We describe a piezoelectric device which allows continuous movement and high-resolution micropositioning, without distance limitation. Both mechanical construction and the electronics for the device are very simple. The movement is obtained via a stick-slip mechanism, and steps as small as 10 nm are obtained. A displacement speed of 0.4 mm/s has been attained, and the device was capable of carrying several times its own weight, exerting a horizontal force, or climbing a plane inclined by 7°. Due to its compact construction, the device shows prospects for miniaturization.

  20. High efficiency photovoltaic device

    DOEpatents

    Guha, Subhendu; Yang, Chi C.; Xu, Xi Xiang

    1999-11-02

    An N-I-P type photovoltaic device includes a multi-layered body of N-doped semiconductor material which has an amorphous, N doped layer in contact with the amorphous body of intrinsic semiconductor material, and a microcrystalline, N doped layer overlying the amorphous, N doped material. A tandem device comprising stacked N-I-P cells may further include a second amorphous, N doped layer interposed between the microcrystalline, N doped layer and a microcrystalline P doped layer. Photovoltaic devices thus configured manifest improved performance, particularly when configured as tandem devices.

  1. 3D printing and milling a real-time PCR device for infectious disease diagnostics.

    PubMed

    Mulberry, Geoffrey; White, Kevin A; Vaidya, Manjusha; Sugaya, Kiminobu; Kim, Brian N

    2017-01-01

    Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device. The key advantage of this approach is the ability to upload the digital format of the design files on the internet for wide distribution so that people at any location can simply download and feed into their 3D printers for quick manufacturing. The material and design are carefully selected to minimize the number of custom parts that depend on advanced manufacturing processes which lower accessibility. The presented 3D manufactured qPCR device is tested with 20-μL samples that contain various concentrations of lentivirus, the same type as HIV. A reverse-transcription step is a part of the device's operation, which takes place prior to the qPCR step to reverse transcribe the target RNA from the lentivirus into complementary DNA (cDNA). This is immediately followed by qPCR which quantifies the target sequence molecules in the sample during the PCR amplification process. The entire process of thermal control and time-coordinated fluorescence reading is automated by closed-loop feedback and a microcontroller. The resulting device is portable and battery-operated, with a size of 12 × 7 × 6 cm3 and mass of only 214 g. By uploading and sharing the design files online, the presented low-cost qPCR device may provide easier access to a robust diagnosis protocol for various infectious diseases, such as HIV and malaria.

  2. A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia.

    PubMed

    Kato, Takayasu; Hangaishi, Akira; Ichikawa, Motoshi; Motokura, Toru; Takahashi, Tsuyoshi; Kurokawa, Mineo

    2009-03-01

    Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report the case of a 44-year-old man with APL carrying a new complex variant translocation (15;22;17). Karyotypic analysis with G-banding of bone marrow cells revealed t(15;22;17) (q22;q11.2;q21). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals. RT-PCR analysis showed long-form PML/RARA fusion transcripts. A complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). This is the first report of a new three-way translocation of 22q11 involvement with APL.

  3. Female pseudohermaphroditism in a fetus with a deletion 9(q22.2q31.1).

    PubMed

    L'Herminé, A Coulomb; Aboura, A; Simon-Bouy, B; Robin, F; Audibert, F; Strouk, N; Capron, F; Frydman, R; Tachdjian, G

    2002-08-01

    Interstitial deletions of chromosomal region 9q are rarely seen. We report the first prenatal diagnosis of a de novo interstitial deletion 9q. The fetus was karyotyped for intrauterine growth retardation (IUGR). Conventional and molecular cytogenetics showed female karyotype with a de novo deletion of the chromosomal region 9(q22.2q31.1) leading to a partial monosomy 9q. At autopsy, the fetus showed growth retardation, dysmorphy, and a female pseudohermaphroditism. These results suggest that a gene(s) for genital development reside in chromosomal region 9q22.2q31.1. Copyright 2002 John Wiley & Sons, Ltd.

  4. New multi-level codes over GF(q)

    NASA Technical Reports Server (NTRS)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1990-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  5. Molecular cytogenetic characterization of a 2q35-q37 duplication and a 4q35.1-q35.2 deletion in two cousins: a genotype-phenotype analysis.

    PubMed

    Ronzoni, Luisa; Peron, Angela; Bianchi, Vera; Baccarin, Marco; Guerneri, Silvana; Silipigni, Rosamaria; Lalatta, Faustina; Bedeschi, Maria Francesca

    2015-07-01

    The 2q3 duplication and 4q3 deletion are two distinct conditions with variable phenotypes including developmental delay, intellectual disability, Pierre Robin sequence (PRS), and cardiovascular, craniofacial, digital and skeletal anomalies. We describe two cousins, a 37-year-old man (Patient 1) and a 17-year-old girl (Patient 2), with a derivative chromosome leading to a 4q35 deletion-2q35q37 duplication. Conventional karyotype showed in both patients the same rearrangement derived from unbalanced segregation of a parental reciprocal translocation involving the long arms of chromosome 2 and 4. Patient 1's father and Patient 2's mother were identified as the carriers of a balanced translocation t(2;4)(q35;q35). Array-CGH analysis, performed to characterize the rearrangement, documented in both patients the presence of a 26 Mb duplication of the 2q35-q37.3 region of chromosome 2 and a 6.3 Mb deletion of the 4q35.1-q35.2 region of chromosome 4. Both patients showed intellectual disability, minor facial, and digital anomalies, hearing, ocular, and genitourinary abnormalities. The comparison of their features with those of published cases of 2q3 duplication and 4q3 deletion allowed us to further delineate the genotype-phenotype correlation as well as the combined effect of partial 2q duplication and 4q deletion syndromes in adulthood.

  6. Extended q -Gaussian and q -exponential distributions from gamma random variables

    NASA Astrophysics Data System (ADS)

    Budini, Adrián A.

    2015-05-01

    The family of q -Gaussian and q -exponential probability densities fit the statistical behavior of diverse complex self-similar nonequilibrium systems. These distributions, independently of the underlying dynamics, can rigorously be obtained by maximizing Tsallis "nonextensive" entropy under appropriate constraints, as well as from superstatistical models. In this paper we provide an alternative and complementary scheme for deriving these objects. We show that q -Gaussian and q -exponential random variables can always be expressed as a function of two statistically independent gamma random variables with the same scale parameter. Their shape index determines the complexity q parameter. This result also allows us to define an extended family of asymmetric q -Gaussian and modified q -exponential densities, which reduce to the standard ones when the shape parameters are the same. Furthermore, we demonstrate that a simple change of variables always allows relating any of these distributions with a beta stochastic variable. The extended distributions are applied in the statistical description of different complex dynamics such as log-return signals in financial markets and motion of point defects in a fluid flow.

  7. Linkage studies with 17q and 18q markers in a breast/ovarian cancer family

    SciTech Connect

    Milner, B.J.; Allan, L.A.; Kelly, K.F.; Johnston, A.; Haites, N. ); Cruickshank, D.; Hall, M.; Kitchener, H.; Parkin, D. )

    1993-04-01

    Genes on chromosomes 17q and 18q have been shown to code for putative tumor suppressors. By a combination of allele-loss studies on sporadic ovarian carcinomas and linkage analysis on a breast/ovarian cancer family, the authors have investigated the involvement of such genes in these diseases. Allele loss occurred in sporadic tumors from both chromosome 17p, in 18/26 (69%) cases, and chromosome 17q, in 15/22 (68%) cases. In the three familial tumors studied, allele loss also occurred on chromosome 17 (in 2/3 cases for 17p markers and in 2/2 cases for a 17q allele). Allele loss on chromosome 18q, at the DCC (deleted in colorectal carcinomas) locus, was not as common (6/16 cases [38%]) in sporadic ovarian tumors but had occurred in all three familial tumors. The results of linkage analysis on the breast/ovarian cancer family suggested linkage between the disease locus and 17q markers, with a maximum lod score of 1.507 obtained with Mfd188 (D17S579) polymorphism at 5% recombination. The maximum lod score for DCC was 0.323 at 0.1% recombination. In this family the results are consistent with a predisposing gene for breast/ovarian cancer being located at chromosome 17q21. 24 refs., 1 fig., 3 tabs.

  8. Beyond low beta-decay Q values

    SciTech Connect

    Mustonen, M. T.; Suhonen, J.

    2010-11-24

    Beta decays with low Q values can be utilized in the quest to determine the neutrino mass scale. This is being realized in two experiments, KATRIN and MARE, using tritium and {sup 187}Re, respectively. The beta-decay of {sup 187}Re had the lowest known Q value until 2005, when the beta decay of {sup 115}In to the first excited state of {sup 115}Sn was discovered in Gran Sasso underground laboratory. Last year two independent ion trap measurements confirmed that this decay breaks the former record by an order of magnitude.Our theoretical study on this tiny decay channel complemented the experimental effort by the JYFLTRAP group in Finland and HADES underground laboratory in Belgium. A significant discrepancy between the experimental and theoretical results was found. This might be explained by various atomic contributions known to grow larger as the Q value decreases. However, the traditional recipes for taking these effects into account break down on this new ultra-low Q value regime, providing new challenges for theorists on the borderline between nuclear and atomic physics.

  9. Deletion 5q35.3

    SciTech Connect

    Stratton, R.F.; Tedrowe, N.A.; Tolworthy, J.A.; Patterson, R.M.; Ryan, S.G.; Young, R.S.

    1994-06-01

    The authors report on a 15-month-old boy with a de novo deletion of the terminal band of 5q, macrocephaly, mild retrognathia, anteverted nares with low flat nasal bridge, telecanthus, minor earlobe anomalies, bellshaped chest, diastasis recti, short fingers, and mild developmental delay.

  10. Q-Method Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Zanetti, Renato; Ainscough, Thomas; Christian, John; Spanos, Pol D.

    2012-01-01

    A new algorithm is proposed that smoothly integrates non-linear estimation of the attitude quaternion using Davenport s q-method and estimation of non-attitude states through an extended Kalman filter. The new method is compared to a similar existing algorithm showing its similarities and differences. The validity of the proposed approach is confirmed through numerical simulations.

  11. A Q-Analysis of Television Programmes.

    ERIC Educational Resources Information Center

    Johnson, J. H.

    1978-01-01

    Documents an experiment in the application of R. H. Atkin's methodology of Q-analysis in the field of television which demonstrates how it may be applied to program schedules. A theoretical discussion illustrates the relationships between the program-time interval backcloth and the viewing patterns it can support. (Author/VT)

  12. Q-Switching in a Neodymium Laser

    ERIC Educational Resources Information Center

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  13. A Q-Analysis of Television Programmes.

    ERIC Educational Resources Information Center

    Johnson, J. H.

    1978-01-01

    Documents an experiment in the application of R. H. Atkin's methodology of Q-analysis in the field of television which demonstrates how it may be applied to program schedules. A theoretical discussion illustrates the relationships between the program-time interval backcloth and the viewing patterns it can support. (Author/VT)

  14. Decay of (p,q)-Fourier coefficients.

    PubMed

    Edmunds, David E; Gurka, Petr; Lang, Jan

    2014-10-08

    We show that essentially the speed of decay of the Fourier sine coefficients of a function in a Lebesgue space is comparable to that of the corresponding coefficients with respect to the basis formed by the generalized sine functions sin p,q .

  15. High Q silicon carbide microdisk resonator

    SciTech Connect

    Lu, Xiyuan; Lee, Jonathan Y.; Feng, Philip X.-L.; Lin, Qiang

    2014-05-05

    We demonstrate a silicon carbide (SiC) microdisk resonator with optical Q up to 5.12 × 10{sup 4}. The high optical quality, together with the diversity of whispering-gallery modes and the tunability of external coupling, renders SiC microdisk a promising platform for integrated quantum photonics applications.

  16. Deletion 14q and pericentric inversion 14.

    PubMed Central

    Nielsen, J; Homma, A; Rasmussen, K; Ried, E; Sorensen, K; Saldana-Garcia, P

    1978-01-01

    A woman with deletion 14q as well as inversion 14 is presented, and physical signs are compared with those of patients with deletion long arm 13. No previous case of deletion long arm 14 has been published. Images PMID:671492

  17. [Q-fever in the Zadar region].

    PubMed

    Barić, D; Vrkić, L

    1995-01-01

    The occurrence of Q fever in a population of Zadar region (2787 km2) which has five microregions (Zadar, Benkovac, Biograd, Obrovac and Pag microregion) is presented. In 1986, nine cases of Q fever were reported. Five patients were detected in Zadar community, one in Pag microregion and 3 in Biograd community and microregion, respectively. In 1989, two cases in Zadar and, in 1988 and 1991, one case in each year from the territory of Zadar were found. A total of 13 cases of Q fever were treated and reported. The personnel of the Zadar Veterinary Stations were not able to provide information since blood samples from the suspected animals were not taken. The agent was therefore not isolated. It is known that there were more serologically proven cases of Q fever, but they were not registered by the Epidemiologic Service of the Zadar Department for Health Protection. Clinical manifestation in a form of pulmonary affection is a very significant data in this zoonosis and it is therefore most commonly detected at the hospital departments for lung diseases, what was one of the reasons for undertaking this study.

  18. Q-Switching in a Neodymium Laser

    ERIC Educational Resources Information Center

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  19. Genetics Home Reference: 15q24 microdeletion

    MedlinePlus

    ... 15q24 microdeletion have occurred in people with no history of the condition in their family. The chromosomal change likely occurs as a random event during the formation of reproductive cells (eggs or sperm) or in early fetal development. Related Information What does it mean ...

  20. Familial complex chromosomal rearrangement resulting in duplication/deletion of 6q14 to 6q16.

    PubMed

    Roland, B; Lowry, R B; Cox, D M; Ferreira, P; Lin, C C

    1993-03-01

    A familial complex chromosomal rearrangement (CCR) was ascertained through a mentally retarded, dysmorphic individual. Carriers of the CCR have the karyotype 46,XX or XY, t(6;15)(q16;q21), ins(3;6)(q12;q14q16), and malsegregation of the CCR resulted in loss of the segment 6q14 to 6q16 in the proband, and in an additional copy of the same segment in three members of the extended family. The proband has features similar to other reported cases with deletion of 6q1. The individuals with duplication of 6q14 to 6q16 have moderate mental retardation, short stature, obesity, microcephaly, brachycephaly, a short smooth philtrum, central hair whorl, simian creases, 5th finger brachydactyly and skeletal disproportion. In the 4-generation family, CCR carriers have a 20% empiric risk of phenotypically abnormal livebirths.

  1. On the q-type distributions

    NASA Astrophysics Data System (ADS)

    Nadarajah, Saralees; Kotz, Samuel

    2007-04-01

    Various q-type distributions have appeared in the physics literature in the recent years, see e.g. L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236 (1997) 52-57. It is pointed out in the paper that many of these are the same as or particular cases of what has been known in the statistics literature. Several of these statistical distributions are discussed and references provided. We feel that this paper could be of assistance for modeling problems of the type considered by L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236

  2. Partial trisomy 14q and monosomy 20q due to an unbalanced familial translocation

    SciTech Connect

    Menasse-Palmer, L; Leo, J.; Cannizaro, L.

    1994-09-01

    Partial trisomy of distal 14q and monosomy of 20q are rare. There have been several reports of a partial distal trisomy 14q with characteristic clinical findings, including hypogonadism and a conotruncal cardiac anomaly. There is no deletion distal 20q syndrome. We have recently examined a newborn with this unique duplication/deletion syndrome. Case report: J.S. was the 2980 gm product of a term uneventful pregnancy delivered to a 24-year-old gravida 2, para 1001 mother. The newborn exam revealed a dysmorphic newborn male with a sloping forehead, bitemporal narrowing, glabellar furrowing and micrognathia. A systolic murmur was audible. The genital abnormalities were micropenis, hypospadias with chordee and bifid scrotum with prominent raphe, and gonads were palpable. A CAT scan of the head revealed grade I IVH. An echocardiogram showed a VSD, ASD and an AP window. A sonogram of the liver showed absence of the gallbladder. Chromosome analysis revealed an abnormal male karyotype containing a derivative 20, subsequently shown to be inherited as a result of malsegregation of a paternal translocation: 46,XY,-20,+der(20)t(14;20)(q32.1;q13.3)pat. The infant fed poorly and required tube feedings and was treated for congestive heart failure with Digoxin, Lasix and oxygen. A decreased cortisol level and cholestasis were noted. The infant died after a cardiopulmonary arrest at one month of age. No post-mortem was obtained. Clinical cytogenetic correlation (conotruncal abnormality and hypogonadism) with partial duplication of distal 14q was positive. This case helps to further delineate duplication 14q and a syndrome due to partial deletion 20q.

  3. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively

    SciTech Connect

    Tamimi, R.M.; Montgomery-Dyer, K.; Tapscott, S.J.

    1997-03-01

    NEUROD2 and NEUROD3 are transcription factors involved in neurogenesis that are related to the basic helix-loop-helix protein NEUROD. NEUROD2 maps to human chromosome 17q12 and mouse chromosome 11. NEUROD3 maps to human chromosome 5q23-q31 and mouse chromosome 13. 16 refs., 2 figs.

  4. q-deformed Painlevé τ function and q-deformed conformal blocks

    NASA Astrophysics Data System (ADS)

    Bershtein, M. A.; Shchechkin, A. I.

    2017-02-01

    We propose the q-deformation of the Gamayun–Iorgov–Lisovyy formula for the Painlevé τ function. Namely, we propose the formula for the τ function for the q-difference Painlevé equation corresponding to the A7(1)\\prime surface (and the A1(1) symmetry) in the Sakai classification. In this formula, the τ function equals the series of q-Virasoro Whittaker conformal blocks (equivalently, the Nekrasov partition functions for pure SU(2) 5d theory).

  5. Study of structural and optical properties of ZnAlQ{sub 5} (zinc aluminum quinolate) organic phosphor for OLED applications

    SciTech Connect

    Nagpure, I. M. Painuly, Deepshikha; Rabanal, Maria Eugenia

    2016-05-06

    The various composition of ZnAlQ{sub 5} such as Zn{sub 1.5}A{sub 10.5}Q{sub 5}, Zn{sub 1}Al{sub 1}Q{sub 5}, Zn{sub 0.5}Al{sub 1.5}Q{sub 5} organic phosphors were prepared via simple cost effective co-precipitation method. The FTIR, SEM, photoluminescence analysis of the prepared phosphors were reported. ZnQ{sub 2} and AlQ{sub 3} were also prepared by similar method and their properties were compared with different composition of ZnAlQ{sub 5}. The structural elucidation in the form of stretching frequencies of chemical bonds of the prepared phosphor was carried out using Fourier Transform Infrared Spectroscopy (FTIR). The stretching frequency analysis confirms the formation of prepared phosphor materials. The SEM analysis shows the surface morphological behavior of prepared phosphor materials. Greenish photoluminescence were observed at 505 to 510 nm for the different composition of ZnAlQ{sub 5},in which Zn{sub 1.5}Al{sub 0.5}Q{sub 5} shows maximum luminescence intensity at 505 nm. PL emission of ZnQ{sub 2} was observed at 515 nm, while for AlQ{sub 3} at 520 nm. The blue shift of 10 nm was observed in Zn{sub 1.5}A{sub 10.5}Q{sub 5} due to modification of energy level due to presence of Zn{sup 2+} and Al{sup 3+}. The enhancement in PL intensity was observed in Zn{sub 1.5}A{sub 10.5}Q{sub 5} compared to the other composition due to transfer of energy between Zn{sup 2+} and quinolate complex. Optical properties of the prepared materials were evaluated for possible applications in organic light emitting devices (OLED).

  6. Assistive Listening Devices

    ERIC Educational Resources Information Center

    Warick, Ruth; Clark, Catherine; Dancer, Jesse; Sinclair, Stephen

    1997-01-01

    For most hard of hearing students, and for some who are deaf, hearing aids and related sound amplification devices are of great benefit in their communication and learning. Technology has more recently produced an additional array of electronic devices which benefit many hard of hearing students. This report will deal primarily with the relatively…

  7. Capillary interconnect device

    SciTech Connect

    Renzi, Ronald F

    2013-11-19

    An interconnecting device for connecting a plurality of first fluid-bearing conduits to a corresponding plurality of second fluid-bearing conduits thereby providing fluid communication between the first fluid-bearing conduits and the second fluid-bearing conduits. The device includes a manifold and one or two ferrule plates that are held by compressive axial forces.

  8. Devices and Educational Change

    ERIC Educational Resources Information Center

    Nespor, Jan

    2011-01-01

    This paper uses Actor Network Theory to examine two cases of device-mediated educational change, one involving a computer-assisted interactive video module that provided a half-hour of instruction for a university course, the other an assistive communication device that proved a supposedly retarded pre-school child to be intelligent. The paper…

  9. Device for removing blackheads

    DOEpatents

    Berkovich, Tamara

    1995-03-07

    A device for removing blackheads from pores in the skin having a elongated handle with a spoon shaped portion mounted on one end thereof, the spoon having multiple small holes piercing therethrough. Also covered is method for using the device to remove blackheads.

  10. Vaginal mechanical contraceptive devices.

    PubMed

    Smith, M; Barwin, B N

    1983-10-01

    The alleged adverse effects of oral contraceptives and intrauterine devices have led to increased consumer and physician demand for vaginal contraceptive devices. The efficacy and the advantages and disadvantages of vaginal sponges, cervical caps and diaphragms are discussed and compared in this article.

  11. Self-actuated device

    DOEpatents

    Hecht, Samuel L.

    1984-01-01

    A self-actuated device, of particular use as a valve or an orifice for nuclear reactor fuel and blanket assemblies, in which a gas produced by a neutron induced nuclear reaction gradually accumulates as a function of neutron fluence. The gas pressure increase occasioned by such accumulation of gas is used to actuate the device.

  12. Advanced resistive exercise device

    NASA Technical Reports Server (NTRS)

    Raboin, Jasen L. (Inventor); Niebuhr, Jason (Inventor); Cruz, Santana F. (Inventor); Lamoreaux, Christopher D. (Inventor)

    2008-01-01

    The present invention relates to an exercise device, which includes a vacuum cylinder and a flywheel. The flywheel provides an inertial component to the load, which is particularly well suited for use in space as it simulates exercising under normal gravity conditions. Also, the present invention relates to an exercise device, which has a vacuum cylinder and a load adjusting armbase assembly.

  13. Mechanical Device Traces Parabolas

    NASA Technical Reports Server (NTRS)

    Soper, Terry A.

    1989-01-01

    Mechanical device simplifies generation of parabolas of various focal lengths. Based on fundamental geometrical construction of parabola. Constancy of critical total distance enforced by maintaining cable in tension. Applications of device include design of paraboloidal antennas, approximating catenaries on drawings of powerlines or long-wire antennas, and general tracing of parabolas on drawings.

  14. Microfabricated particle focusing device

    DOEpatents

    Ravula, Surendra K.; Arrington, Christian L.; Sigman, Jennifer K.; Branch, Darren W.; Brener, Igal; Clem, Paul G.; James, Conrad D.; Hill, Martyn; Boltryk, Rosemary June

    2013-04-23

    A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

  15. Emergency-escape device

    NASA Technical Reports Server (NTRS)

    Broussard, P. M.

    1973-01-01

    Relatively simple inexpensive device uses reeled steel cable, is controlled by automotive-type shock absorber, and allows safe descent from burning building. Device is cheap to manufacture and assemble and requires neither skill, special knowledge, or athletic ability to operate. It is reliable and fireproof and can be deployed instantly.

  16. STORM INLET FILTRATION DEVICE

    EPA Science Inventory

    Five field tests were conducted to evaluate the effectiveness of the Storm and Groundwater Enhancement Systems (SAGES) device for removing contaminants from stormwater. The SAGES device is a three-stage filtering system that could be used as a best management practices (BMP) retr...

  17. Inverted organic photosensitive devices

    DOEpatents

    Forrest, Stephen R.; Bailey-Salzman, Rhonda F.

    2016-12-06

    The present disclosure relates to organic photosensitive optoelectronic devices grown in an inverted manner. An inverted organic photosensitive optoelectronic device of the present disclosure comprises a reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode on top of the donor-acceptor heterojunction.

  18. Assistive Listening Devices

    ERIC Educational Resources Information Center

    Warick, Ruth; Clark, Catherine; Dancer, Jesse; Sinclair, Stephen

    1997-01-01

    For most hard of hearing students, and for some who are deaf, hearing aids and related sound amplification devices are of great benefit in their communication and learning. Technology has more recently produced an additional array of electronic devices which benefit many hard of hearing students. This report will deal primarily with the relatively…

  19. STORM INLET FILTRATION DEVICE

    EPA Science Inventory

    Five field tests were conducted to evaluate the effectiveness of the Storm and Groundwater Enhancement Systems (SAGES) device for removing contaminants from stormwater. The SAGES device is a three-stage filtering system that could be used as a best management practices (BMP) retr...

  20. Devices and Educational Change

    ERIC Educational Resources Information Center

    Nespor, Jan

    2011-01-01

    This paper uses Actor Network Theory to examine two cases of device-mediated educational change, one involving a computer-assisted interactive video module that provided a half-hour of instruction for a university course, the other an assistive communication device that proved a supposedly retarded pre-school child to be intelligent. The paper…

  1. Emergency descent device

    NASA Technical Reports Server (NTRS)

    Belew, R. R.

    1974-01-01

    Device includes cable wound on reel; special assembly enclosed in fluid medium controls unwinding speed of cable during descent. Device is compact and reliable. It can be rewound quickly because reel disengages from latches when it is turned in opposite direction.

  2. Microwave device investigations

    NASA Technical Reports Server (NTRS)

    Choudhury, K. K. D.; Haddad, G. I.; Kwok, S. P.; Masnari, N. A.; Trew, R. J.

    1972-01-01

    Materials, devices and novel schemes for generation, amplification and detection of microwave and millimeter wave energy are studied. Considered are: (1) Schottky-barrier microwave devices; (2) intermodulation products in IMPATT diode amplifiers; and (3) harmonic generation using Read diode varactors.

  3. Statement on intrauterine devices.

    PubMed

    1981-12-01

    These policy statements and guidelines from the International Planned Parenthood Federation's (IPPF) International Medical Advisory Panel (IMAP) concern IUDs. The following contraindications to IUD use are recognized: 1) pelvic inflaminatory disease, 2) known or suspected pregnancy, 3) history of previous ectopic pregnancy, 4) gynecological bleeding disorders, 5) suspected malignancy of the genital tract, 6) congenital uterine abnormalities or fibroids distorting the cavity, and 7) anemia, blood coagulation, severe cervical stenosis, copper allergy, Wilson's disease, and others. Generalities regarding appropriate IUDs are: 1) non-medicated devices (e.g. Lippes Loop) are studied for women who may not return for regular check-ups, 2) smaller medicated devices usually cause less menstrual blood loss than the non-medicated devices, 3) smaller devices are better for a smaller uterus and larger devices for the larger uterus, and 4) when a smaller device is expelled it is advisable to try a larger one and vice versa. Dalkon Shields should not be used by the IPPF system and all women using them should have the device removed. Correct insertion of IUDs is important and should be done by properly trained personnel. The timing of insertion is best during the menstrual period. Withdrawal of the applicator while leaving the device in place is the recommended insertion technique. Sterilization of IUDs should follow instructions on bulk-packaged IUDs. Complications include perforation, bleeding and pain, infection, and ectopic pregnancy. IUD removal should be done during menstruation. Good clinical management and follow-up care are recommended.

  4. Heat tube device

    NASA Technical Reports Server (NTRS)

    Khattar, Mukesh K. (Inventor)

    1990-01-01

    The present invention discloses a heat tube device through which a working fluid can be circulated to transfer heat to air in a conventional air conditioning system. The heat tube device is disposable about a conventional cooling coil of the air conditioning system and includes a plurality of substantially U-shaped tubes connected to a support structure. The support structure includes members for allowing the heat tube device to be readily positioned about the cooling coil. An actuatable adjustment device is connected to the U-shaped tubes for allowing, upon actuation thereof, for the heat tubes to be simultaneously rotated relative to the cooling coil for allowing the heat transfer from the heat tube device to air in the air conditioning system to be selectively varied.

  5. Fluidic nanotubes and devices

    DOEpatents

    Yang, Peidong; He, Rongrui; Goldberger, Joshua; Fan, Rong; Wu, Yiying; Li, Deyu; Majumdar, Arun

    2010-01-10

    Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

  6. Fluidic nanotubes and devices

    DOEpatents

    Yang, Peidong [Berkeley, CA; He, Rongrui [El Cerrito, CA; Goldberger, Joshua [Berkeley, CA; Fan, Rong [El Cerrito, CA; Wu, Yiying [Albany, CA; Li, Deyu [Albany, CA; Majumdar, Arun [Orinda, CA

    2008-04-08

    Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

  7. Fluidic nanotubes and devices

    DOEpatents

    Yang, Peidong; He, Rongrui; Goldberger, Joshua; Fan, Rong; Wu, Yiying; Li, Deyu; Majumdar, Arun

    2008-04-08

    Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

  8. Device for cutting protrusions

    DOEpatents

    Bzorgi, Fariborz M [Knoxville, TN

    2011-07-05

    An apparatus for clipping a protrusion of material is provided. The protrusion may, for example, be a bolt head, a nut, a rivet, a weld bead, or a temporary assembly alignment tab protruding from a substrate surface of assembled components. The apparatus typically includes a cleaver having a cleaving edge and a cutting blade having a cutting edge. Generally, a mounting structure configured to confine the cleaver and the cutting blade and permit a range of relative movement between the cleaving edge and the cutting edge is provided. Also typically included is a power device coupled to the cutting blade. The power device is configured to move the cutting edge toward the cleaving edge. In some embodiments the power device is activated by a momentary switch. A retraction device is also generally provided, where the retraction device is configured to move the cutting edge away from the cleaving edge.

  9. Planar electrochemical device assembly

    DOEpatents

    Jacobson, Craig P.; Visco, Steven J.; De Jonghe, Lutgard C.

    2007-06-19

    A pre-fabricated electrochemical device having a dense electrolyte disposed between an anode and a cathode preferably deposited as thin films is bonded to a porous electrically conductive support. A second porous electrically conductive support may be bonded to a counter electrode of the electrochemical device. Multiple electrochemical devices may be bonded in parallel to a single porous support, such as a perforated sheet to provide a planar array. Planar arrays may be arranged in a stacked interconnected array. A method of making a supported electrochemical device is disclosed wherein the method includes a step of bonding a pre-fabricated electrochemical device layer to an existing porous metal or porous metal alloy layer.

  10. Planar electrochemical device assembly

    DOEpatents

    Jacobson; Craig P. , Visco; Steven J. , De Jonghe; Lutgard C.

    2010-11-09

    A pre-fabricated electrochemical device having a dense electrolyte disposed between an anode and a cathode preferably deposited as thin films is bonded to a porous electrically conductive support. A second porous electrically conductive support may be bonded to a counter electrode of the electrochemical device. Multiple electrochemical devices may be bonded in parallel to a single porous support, such as a perforated sheet to provide a planar array. Planar arrays may be arranged in a stacked interconnected array. A method of making a supported electrochemical device is disclosed wherein the method includes a step of bonding a pre-fabricated electrochemical device layer to an existing porous metal or porous metal alloy layer.

  11. The Value of Coenzyme Q10 Determination in Mitochondrial Patients

    PubMed Central

    Yubero, Delia; Allen, George; Artuch, Rafael; Montero, Raquel

    2017-01-01

    Coenzyme Q10 (CoQ) is a lipid that is ubiquitously synthesized in tissues and has a key role in mitochondrial oxidative phosphorylation. Its biochemical determination provides insight into the CoQ status of tissues and may detect CoQ deficiency that can result from either an inherited primary deficiency of CoQ metabolism or may be secondary to different genetic and environmental conditions. Rapid identification of CoQ deficiency can also allow potentially beneficial treatment to be initiated as early as possible. CoQ may be measured in different specimens, including plasma, blood mononuclear cells, platelets, urine, muscle, and cultured skin fibroblasts. Blood and urinary CoQ also have good utility for CoQ treatment monitoring. PMID:28338638

  12. Ordered-subset analysis of savant skills in autism for 15q11-q13.

    PubMed

    Ma, D Q; Jaworski, J; Menold, M M; Donnelly, S; Abramson, R K; Wright, H H; Delong, G R; Gilbert, J R; Pericak-Vance, M A; Cuccaro, Michael L

    2005-05-05

    Autism is a complex disorder characterized by genetic and phenotypic heterogeneity. Analysis of phenotypically homogeneous subtypes has been used to both confirm and narrow potential autism linkage regions such as the chromosomal region 15q11-q13. Increased evidence for linkage in this region had been found in a subgroup of 21 autism families (total families = 94) stratified based on a savant skill factor (SSF) from the Autism Diagnostic Interview, Revised (ADI-R). We examined the savant phenotypic finding in our sample of 91 multiplex autism families. Using two-point parametric analysis in stratification with a cutoff point of a savant skill score of 0.16, our families failed to demonstrate linkage to 15q11-q13. In addition, ordered subset analysis (OSA) using SSF as a covariate also failed to show evidence for linkage. Our findings do not support savant skills as an informative phenotypic subset for linkage in our sample. Copyright 2005 Wiley-Liss, Inc.

  13. De novo direct duplication of chromosome segment 22q11.2-q13.1

    SciTech Connect

    Fujimoto, Atsuko; Lin, Ming S.

    1996-03-29

    Lindsay et al. [1995] reported a case of de novo duplication of the segment 22q11-q12. Molecular cytogenetics studies showed that the segment includes the regions responsible for the {open_quotes}cat eye,{close_quotes} DiGeorge, and velo-cardio-facial syndrome, and extends distal to the breakpoint cluster region. The phenotype was milder than that of complete trisomy 22 and der(22)t(11;22) (q23;q11) syndrome and was similar in type and severity to that of {open_quotes}cat eye{close_quotes} syndrome (CES). They suggested that trisomy of gene(s) responsible for the CES might have a predominant phenotypic effect over other genes present in the region duplicated in their patient. 3 refs., 2 figs.

  14. Wave functions of the Q .Q interaction in terms of unitary 9-j coefficients

    NASA Astrophysics Data System (ADS)

    Zamick, Larry; Harper, Matthew

    2015-03-01

    We obtain wave functions for two protons and two neutrons in the g9 /2 shell expressed as column vectors with amplitudes D (Jp,Jn) . When we use a quadrupole-quadrupole interaction (Q .Q ) we get, in many cases, a very strong overlap with wave functions given by a single set of unitary 9-j coefficients—U 9 j =<(jj ) 2 j(jjJB|(jj ) Jp(jj ) Jn) I> . Here JB=9 for even I T =0 states. For both even and odd T =1 states we take JB equal to 8 whilst for odd I ,T =0 we take JB to be 7. We compare the Q .Q results with those of a more realistic interaction.

  15. Selective excitation of high-Q resonant modes in a bottle/quasi-cylindrical microresonator

    NASA Astrophysics Data System (ADS)

    Dong, Yongchao; Jin, Xueying; Wang, Keyi

    2016-08-01

    We fabricate a bottle/quasi-cylindrical microresonator by using a fusion splicer. This method does not require a real-time control of the translation stages and can easily fabricate a resonator with expected size and shape. Selective excitation of whispering gallery modes (WGMs) in the resonator is realized with a fiber taper coupled at various positions of the resonator along the bottle axis. Most importantly, we obtain a clean and regular spectrum with very high quality factor (Q) modes up to 3.1×107 in the quasi-cylindrical region of the resonator. Moreover, we package the coupling system into a whole device that can be moved freely. The vibration performance tests of the packaged device show that the coupling system with the taper coupled at the quasi-cylindrical region has a remarkable anti-vibration ability. The portability and robustness of the device make it attractive in practical applications.

  16. Optical thin film devices

    NASA Astrophysics Data System (ADS)

    Mao, Shuzheng

    1991-11-01

    Thin film devices are applied to almost all modern scientific instruments, and these devices, especially optical thin film devices, play an essential role in the performances of the instruments, therefore, they are attracting more and more attention. Now there are numerous kinds of thin film devices and their applications are very diversified. The 300-page book, 'Thin Film Device and Applications,' by Prof. K. L. Chopra gives some general ideas, and my paper also outlines the designs, fabrication, and applications of some optical thin film devices made in my laboratory. Optical thin film devices have been greatly developed in the recent decades. Prof. A. Thelan has given a number of papers on the theory and techniques, Prof. H. A. Macleod's book, 'Thin Film Optical Filters,' has concisely concluded the important concepts of optical thin film devices, and Prof. J. A. Dobrowobski has proposed many successful designs for optical thin film devices. Recently, fully-automatic plants make it easier to produce thin film devices with various spectrum requirements, and some companies, such as Balzers, Leybold AG, Satis Vacuum AG, etc., have manufactured such kinds of coating plants for research or mass-production, and the successful example is the production of multilayer antireflection coatings with high stability and reproducibility. Therefore, it could be said that the design of optical thin film devices and coating plants is quite mature. However, we cannot expect that every problem has been solved, the R&D work still continues, the competition still continues, and new design concepts, new techniques, and new film materials are continually developed. Meanwhile, the high-price of fully-automatic coating plants makes unpopular, and automatic design of coating stacks is only the technique for optimizing the manual design according to the physical concepts and experience, in addition, not only the optical system, but also working environment should be taken into account when

  17. Deletion 22q13.3 syndrome.

    PubMed

    Phelan, Mary C

    2008-05-27

    The deletion 22q13.3 syndrome (deletion 22q13 syndrome or Phelan-McDermid syndrome) is a chromosome microdeletion syndrome characterized by neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, and minor dysmorphic features. The deletion occurs with equal frequency in males and females and has been reported in mosaic and non-mosaic forms. Due to lack of clinical recognition and often insufficient laboratory testing, the syndrome is under-diagnosed and its true incidence remains unknown. Common physical traits include long eye lashes, large or unusual ears, relatively large hands, dysplastic toenails, full brow, dolicocephaly, full cheeks, bulbous nose, and pointed chin. Behavior is autistic-like with decreased perception of pain and habitual chewing or mouthing. The loss of 22q13.3 can result from simple deletion, translocation, ring chromosome formation and less common structural changes affecting the long arm of chromosome 22, specifically the region containing the SHANK3 gene. The diagnosis of deletion 22q13 syndrome should be considered in all cases of hypotonia of unknown etiology and in individuals with absent speech. Although the deletion can sometimes be detected by high resolution chromosome analysis, fluorescence in situ hybridization (FISH) or array comparative genomic hybridization (CGH) is recommended for confirmation. Differential diagnosis includes syndromes associated with hypotonia, developmental delay, speech delay and/or autistic-like affect (Prader-Willi, Angelman, Williams, Smith-Magenis, Fragile X, Sotos, FG, trichorhinophalangeal and velocardiofacial syndromes, autism spectrum disorders, cerebral palsy). Genetic counseling is recommended and parental laboratory studies should be considered to identify cryptic rearrangements and detect parental mosaicism. Prenatal diagnosis should be offered for future pregnancies in those families with inherited rearrangements. Individuals with

  18. Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13.

    PubMed Central

    Cannizzaro, L A; Croce, C M; Griffin, C A; Simeone, A; Boncinelli, E; Huebner, K

    1987-01-01

    Four human homeo box-containing cDNAs isolated from mRNA of an SV40-transformed human fibroblast cell line have been regionally localized on the human gene map. One cDNA clone, c10, was found to be nearly identical to the previously mapped Hox-2.1 gene at 17q21. A second cDNA clone, c1, which is 87% homologous to Hox-2.2 at the nucleotide level but is distinct from Hox-2.1 and Hox-2.2, also maps to this region of human chromosome 17 and is probably another member of the Hox-2 cluster of homeo box-containing genes. The third cDNA clone, c8, in which the homeo box is approximately 84% homologous to the mouse Hox-1.1 homeo box region on mouse chromosome 6, maps to chromosome region 12q12----12q13, a region that is involved in chromosome abnormalities in human seminomas and teratomas. The fourth cDNA clone, c13, whose homeo box is approximately 73% homologous to the Hox-2.2 homeo box sequence, is located at chromosome region 2q31----q37. The human homeo box-containing cluster of genes at chromosome region 17q21 is the human cognate of the mouse homeo box-containing gene cluster on mouse chromosome 11. Other mouse homeo box-containing genes of the Antennapedia class (class I) map to mouse chromosomes 6 (Hox-1, proximal to the IgK locus) and 15 (Hox-3). A mouse gene, En-1, with an engrailed-like homeo box (class II) and flanking region maps to mouse chromosome 1 (near the dominant hemimelia gene). Neither of the class I homeo box-containing genes--c8 and c13--maps to a region of obvious homology to chromosomal positions of the presently known mouse homeo box-containing genes. Images Fig. 2 Fig. 3 Fig. 5 PMID:2886047

  19. Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)

    PubMed Central

    2014-01-01

    Summary A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules. PMID:24991286

  20. Comparison of the Q-switched alexandrite, Nd:YAG, and ruby lasers in treating blue-black tattoos.

    PubMed

    Leuenberger, M L; Mulas, M W; Hata, T R; Goldman, M P; Fitzpatrick, R E; Grevelink, J M

    1999-01-01

    A new generation of highly selective short-pulsed lasers has emerged in recent years for the treatment of tattoos. Several studies (including reports by the present investigators) have proven the efficacy of each of the three commercially available, FDA approved devices; namely, the Q-switched alexandrite, Q-switched Nd:YAG and Q-switched ruby lasers. Considerable differences among the three have been reported in relation to the rate of clearing of the tattoo ink particles, tissue effects, beam profile, wound healing, and side effects. This study was primarily conducted to examine and compare the clinical response of patients with blue-black tattoos simultaneously treated with three different Q-switched lasers (alexandrite, Nd:YAG, ruby) with a focus on the percentage of tattoo lightening/clearance and the occurrence or non-occurrence of pigmentary change as a side effect. A total of forty-two blue-black tattoos seen at two laser centers (Massachusetts General Hospital Dermatology Laser Center and Laser and Skin Surgery Center of La Jolla) were simultaneously treated with three types of Q-switched lasers: a Candela Q-switched alexandrite laser (755nm 50-100 nanoseconds, 3.0 mm spot size, 6-8 J/cm2); a Continuum Biomedical Q-switched Nd:YAG laser (1064nm, 10-20 nanoseconds, 3.0 mm spot size, 5-10 J/cm2); and a Spectrum Q-switched ruby laser (694 nm, 25-40 nanoseconds, 5.0 mm spot size, 4-10 J/cm2). Paired t-tests and McNemar tests were used to compare the treatment outcome and pigmentation side effects between sites per tattoo, with each site representative of one of the three lasers. The statistical significance level was set at p < .05. Overall, the Q-switched ruby laser had a significant difference in tattoo lightening versus the Q-switched Nd:YAG and Q-switched alexandrite lasers. An increase in the number of treatments paralleled a statistically significant increase in tattoo clearance for all three Q-switched lasers. The Q-switched ruby laser had the highest

  1. Dermatoglyphics and Reproductive Risk in a Family with Robertsonian Translocation 14q;21q

    PubMed Central

    Kolgeci, Selim; Kolgeci, Jehona; Azemi, Mehmedali; Daka, Aferdita; Shala-Beqiraj, Ruke; Kurtishi, Ilir; Sopjani, Mentor

    2015-01-01

    Aim: The present study is carried out to evaluate the risk of giving birth to children with Down syndrome in a family with Robertsonian translocation 14q;21q, and to find the dermatoglyphic changes present in carriers of this translocation. Methods: Cytogenetics diagnosis has been made according to Moorhead and Seabright method, while the analysis of prints (dermatoglyphics analysis) was made with the Cummins and Midlo method. Results: Cytogenetic diagnosis has been made in a couple who suffered the spontaneous miscarriages and children with Down syndrome. Robertsonian translocation between chromosomes 14 and 21 (45, XX, der (14; 21) (q10; q10)) was found in a female partner who had four pregnancies, in two of which was found fetus karyotype with trisomy in chromosome 21 and pregnancies were terminated. The outcome of fourth pregnancy was twin birth, one of them with normal karyotype and another with Down syndrome due to Robertsonian translocation inherited by mother side. Specific dermatoglyphics traits are found in the child carrying Down syndrome, whereas several traits of dermatoglyphics characteristic of Down syndrome have been displayed among the silent carriers of Robertsonian translocation 14q;21q. Conclusion: Robertsonian translocation found in female partner was the cause of spontaneous miscarriages, of giving birth to a child with Down syndrome, and of trisomy of chromosome 21 due to translocation in two pregnancies. PMID:26236088

  2. Common variants at 6q22 and 17q21 are associated with intracranial volume

    PubMed Central

    Ikram, M. Arfan; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhold; Debette, Stéphanie; Vrooman, Henri A.; Sigurdsson, Sigurdur; Ropele, Stefan; Taal, H. Rob; Mook-Kanamori, Dennis O.; Coker, Laura H.; Longstreth, W.T.; Niessen, Wiro J.; DeStefano, Anita L.; Beiser, Alexa; Zijdenbos, Alex P.; Struchalin, Maksim; Jack, Clifford R.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Knopman, David S.; Hartikainen, Anna-Liisa; Pennell, Craig E.; Thiering, Elisabeth; Steegers, Eric A.P.; Hakonarson, Hakon; Heinrich, Joachim; Palmer, Lyle J; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Grant, Struan F.A.; St Pourcain, Beate; Timpson, Nicholas J; Smith, George Davey; Sovio, Ulla; Nalls, Mike A.; Au, Rhoda; Hofman, Albert; Gudnason, Haukur; van der Lugt, Aad; Harris, Tamara B.; Meeks, William M.; Vernooij, Meike W.; van Buchem, Mark A.; Catellier, Diane; Jaddoe, Vincent W.V.; Gudnason, Vilmundur; Windham, B. Gwen; Wolf, Philip A.; van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Helena; Launer, Lenore J.; Breteler, Monique M.B.; DeCarli, Charles

    2012-01-01

    During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study in 8,175 community-dwelling elderly did not reveal any genome-wide significant associations (p<5*10−8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (p=3.4*10−11), a known height locus on chromosome 6q22, and rs9915547, tagging the inversion on chromosome 17q21 (p=1.5*10−12). We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 older persons (p=1.1*10−3 for 6q22 and p=1.2*10−3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age 14.5 months). Our data identify two loci associated with head size, with the inversion on 17q21 also likely involved in attaining maximal brain size. PMID:22504418

  3. Generalization of the possible algebraic basis of q-triplets

    NASA Astrophysics Data System (ADS)

    Tsallis, Constantino

    2017-02-01

    The so called q-triplets were conjectured in 2004 [C. Tsallis, Physica A 340, 1 (2004)] and then found in nature in 2005 [L.F. Burlaga, A.F. Vinas, Physica A 356, 375 (2005)]. A relevant further step was achieved in 2005 [C. Tsallis, M. Gell-Mann, Y. Sato, PNAS 102, 15377 (2005)] when the possibility was advanced that they could reflect an entire infinite algebra based on combinations of the self-dual relations q → 2 - q ( additive duality) and q → 1/ q ( multiplicative duality). The entire algebra collapses into the single fixed point q = 1, corresponding to the Boltzmann-Gibbs entropy and statistical mechanics. For q ≠ 1, an infinite set of indices q appears, corresponding in principle to an infinite number of physical properties of a given complex system describable in terms of the so called q-statistics. The basic idea that is put forward is that, for a given universality class of systems, a small number (typically one or two) of independent q indices exist, the infinite others being obtained from these few ones by simply using the relations of the algebra. The q-triplets appear to constitute a few central elements of the algebra. During the last decade, an impressive amount of q-triplets have been exhibited in analytical, computational, experimental and observational results in natural, artificial and social systems. Some of them do satisfy the available algebra constructed solely with the additive and multiplicative dualities, but some others seem to violate it. In the present work we generalize those two dualities with the hope that a wider set of systems can be handled within. The basis of the generalization is given by the selfdual relation qq a ( q) ≡ (( a+2)- aq) / ( a-( a-2) q) ( a ∈ R). We verify that q a (1) = 1, and that q 2( q) = 2 - q and q 0( q) = 1/ q. To physically motivate this generalization, we briefly review illustrative applications of q-statistics, in order to exhibit possible candidates where the present generalized

  4. Ectrodactyly and proximal/intermediate interstitial deletion 7q

    SciTech Connect

    McElveen, C.; Carvajal, M.V.; Moscatello, D.

    1995-03-13

    We report on an individual with severe mental retardation, seizures, microcephaly, unusual face, scoliosis, and cleft feet and cleft right hand. The chromosomal study showed a proximal interstitial deletion 7q (q11.23q22). From our review of the literature, 11 patients have been reported with ectrodactyly (split hand/split foot malformation) and proximal/intermediate interstitial deletions or rearrangements of 7q. The critical segment for ectrodactyly seems to be located between 7q21.2 and 7q22.1. This malformation is present in 41% of the patients whose deletion involves the critical segment. 37 refs., 3 figs., 1 tab.

  5. A novel five-way translocation, t(3;9;13;8;14)(q27;p13;q32;q24;q32), with concurrent MYC and BCL6 rearrangements in a primary bone marrow B-cell lymphoma.

    PubMed

    Yamamoto, Katsuya; Matsuoka, Hiroshi; Yakushijin, Kimikazu; Funakoshi, Yohei; Okamura, Atsuo; Hayashi, Yoshitake; Minami, Hironobu

    2011-09-01

    Chromosomal translocations involving MYC at 8q24 are found in Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL (BCLU). Here, we describe a novel five-way translocation, t(3;9;13;8;14)(q27;p13;q32;q24;q32), involving MYC, BCL6, and the immunoglobulin heavy locus (IGH@) in a 73-year-old man with BCLU. The bone marrow was massively infiltrated with 95.6% abnormal medium- to large-sized lymphoid cells without vacuoles. Flow cytometric analyses indicated that the infiltrating cells were positive for CD10, CD19, CD20, CD25, HLA-DR, and κ chain. Immunohistochemistry revealed that they were also positive for BCL2 and CD10, and weakly positive for BCL6. The MIB1 index was approximately 99%. G-banding and spectral karyotyping demonstrated the presence of a t(3;9;13;8;14)(q27;p13;q32;q24;q32). Fluorescence in situ hybridization detected an IGH/MYC fusion signal on the der(14)t(8;14)(q24;q32). In addition, 5' and 3'BCL6 signals were separated onto the der(9)t(3;9)(q27;p13) and the der(3)t(3;14)(q27;q32), respectively. Unexpectedly, no BCL6 signal was found on the non-translocated chromosome 3. Finally, the revised karyotype was as follows: 49,XY,del(3)(q27q27),t(3;9;13;8;14)(q27;p13;q32;q24;q32), +der(6)t(6;13)(q13;q32)t(9;13)(p13;q32),+7,+12,i(18)(q10)[2]/50,sl,+7[2]/50,sl,+2[1]. These results suggest that this five-way translocation could bring about the deregulated expression of MYC on the der(14)t(8;14) and BCL6 on the der(3)t(3;14) by the IGH@ enhancer/promoter in a single event and may have contributed to the development of this BCLU.

  6. The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice.

    PubMed

    Lönnrot, K; Holm, P; Lagerstedt, A; Huhtala, H; Alho, H

    1998-04-01

    The effect of lifelong oral supplementation with ubiquinone Q10 (10 mg/kg/day) was examined in Sprague-Dawley rats and C57/B17 mice. There were no significant differences in survival or life-span found in either rats or mice. Histopathologic examination of different rat tissues showed no differences between the groups. In Q10 supplemented rats, plasma and liver Q10 levels were 2.6 to 8.4 times higher at all age points than in control rats. Interestingly, in supplemented rats the Q9 levels also were significantly higher (p<0.05) in plasma and liver at ages 18 and 24 months. Neither Q9 nor Q10 levels were affected by supplementation in kidney, heart, or brain tissues. In spite of the significant changes in plasma and liver ubiquinone concentrations, lifelong Q10 supplementation did not prolong or shorten the lifespan of either rats or mice.

  7. Enhancing the resonance stability of a high-Q micro/nanoresonator by an optical means

    NASA Astrophysics Data System (ADS)

    Sun, Xuan; Luo, Rui; Zhang, Xi-Cheng; Lin, Qiang

    2016-02-01

    High-quality optical resonators underlie many important applications ranging from optical frequency metrology, precision measurement, nonlinear/quantum photonics, to diverse sensing such as detecting single biomolecule, electromagnetic field, mechanical acceleration/rotation, among many others. All these applications rely essentially on the stability of optical resonances, which, however, is ultimately limited by the fundamental thermal fluctuations of the devices. The resulting thermo-refractive and thermo-elastic noises have been widely accepted for nearly two decades as the fundamental thermodynamic limit of an optical resonator, limiting its resonance uncertainty to a magnitude 10-12 at room temperature. Here we report a novel approach that is able to significantly improve the resonance stability of an optical resonator. We show that, in contrast to the common belief, the fundamental temperature fluctuations of a high-Q micro/nanoresonator can be suppressed remarkably by pure optical means without cooling the device temperature, which we term as temperature squeezing. An optical wave with only a fairly moderate power launched into the device is able to produce strong photothermal backaction that dramatically suppresses the spectral intensity of temperature fluctuations by five orders of magnitudes and squeezes the overall level (root-mean-square value) of temperature fluctuations by two orders of magnitude. The proposed approach is universally applicable to various micro/nanoresonator platforms and the optimal temperature squeezing can be achieved with an optical Q around 106-107 that is readily available in various current devices. The proposed photothermal temperature squeezing is expected to have profound impact on broad applications of high-Q cavities in sensing, metrology, and integrated nonlinear/quantum photonics.

  8. Enabling ICH Q10 Implementation--Part 1. Striving for Excellence by Embracing ICH Q8 and ICH Q9.

    PubMed

    Calnan, Nuala; O'Donnell, Kevin; Greene, Anne

    2013-01-01

    This article is the first in a series of articles that will focus on understanding the implementation essentials necessary to deliver operational excellence through a International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Q10-based pharmaceutical quality system (PQS). The authors examine why, despite the fact that the ICH Q10 guideline has been with us since 2008, the transformation of the traditional Quality Management Systems QMS in use within the pharmaceutical industry is a work in progress for only a few forward-thinking organisations. Unfortunately, this transformation remains a mere aspiration for the majority of organisations. We explore the apparent lack of progress by the pharmaceutical sector in adopting six sigma and related quality management techniques to ensure the availability of high-quality medicines worldwide. The authors propose that the desired progress can be delivered through two key shifts in our current practices; by embodying the principles of operational excellence in every aspect of our business and by learning how to unlock the scientific and tacit knowledge within our organisations. It has been ten years since The Wall Street Journal revealed the pharmaceutical industry's "little secret" comparing the perceived level of manufacturing expertise in the industry as lagging far behind those of potato-chip and laundry-soap makers. Would you consider the quality and manufacturing strategies in place today in your organisation to be more efficient and scientifically based than those of 2003? If so, what evidence exists for you to draw any conclusion regarding enhanced performance? Do your current practices drive innovation and facilitate continual improvement and if so, how? Ultimately, can you confidently affirm that patient-related risks associated with the product(s) manufactured by your organisation have been reduced due to the quality assurance program now applied

  9. Cosmetics Safety Q&A: Shelf Life

    MedlinePlus

    ... page Labeling & Label Claims Potential Contaminants Products & Ingredients Product Testing Recalls & Alerts Resources for Consumers FDA Basics Cosmetics ... Areas back Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products

  10. Mobile Ad-Hoc Networking on Android Devices

    DTIC Science & Technology

    2014-03-01

    2012 Android and iOS devices dominated the market share with 75.0% and 14.9%, respectively (5). This strongly suggested Android devices as our platform...networks, it lacks the ability to create them. This lack of ability and the fact that the Android operating system is open source, while iOS is very...Battlefield Scenarios; U.S. Army Research Laboratory: Aberdeen Proving Ground, MD To be published in 2014. 4. Kerr, D. Android beats iOS 5-to-1 in Q3

  11. INTERNAL CUTTING DEVICE

    DOEpatents

    Russell, W.H. Jr.

    1959-06-30

    A device is described for removing material from the interior of a hollow workpiece so as to form a true spherical internal surface in a workpiece, or to cut radial slots of an adjustable constant depth in an already established spherical internal surface. This is accomplished by a spring loaded cutting tool adapted to move axially wherein the entire force urging the tool against the workpiece is derived from the spring. Further features of importance involve the provision of a seal between the workpiece and the cutting device and a suction device for carrying away particles of removed material.

  12. Wireless quantified reflex device

    NASA Astrophysics Data System (ADS)

    Lemoyne, Robert Charles

    The deep tendon reflex is a fundamental aspect of a neurological examination. The two major parameters of the tendon reflex are response and latency, which are presently evaluated qualitatively during a neurological examination. The reflex loop is capable of providing insight for the status and therapy response of both upper and lower motor neuron syndromes. Attempts have been made to ascertain reflex response and latency, however these systems are relatively complex, resource intensive, with issues of consistent and reliable accuracy. The solution presented is a wireless quantified reflex device using tandem three dimensional wireless accelerometers to obtain response based on acceleration waveform amplitude and latency derived from temporal acceleration waveform disparity. Three specific aims have been established for the proposed wireless quantified reflex device: 1. Demonstrate the wireless quantified reflex device is reliably capable of ascertaining quantified reflex response and latency using a quantified input. 2. Evaluate the precision of the device using an artificial reflex system. 3.Conduct a longitudinal study respective of subjects with healthy patellar tendon reflexes, using the wireless quantified reflex evaluation device to obtain quantified reflex response and latency. Aim 1 has led to the steady evolution of the wireless quantified reflex device from a singular two dimensional wireless accelerometer capable of measuring reflex response to a tandem three dimensional wireless accelerometer capable of reliably measuring reflex response and latency. The hypothesis for aim 1 is that a reflex quantification device can be established for reliably measuring reflex response and latency for the patellar tendon reflex, comprised of an integrated system of wireless three dimensional MEMS accelerometers. Aim 2 further emphasized the reliability of the wireless quantified reflex device by evaluating an artificial reflex system. The hypothesis for aim 2 is that

  13. Automobile maneuvering device

    SciTech Connect

    Ricciardi, R.

    1987-08-18

    An automobile maneuvering device is described which consists of: a chassis comprising transport wheels for permitting movement of the device along the ground, a drive wheel operably rotatably connected to the chassis, and means for rotating the drive wheel, clamp means operably connected to the chassis and spaced from and opposed to the drive wheel, the chassis including means to move the clamp means to engage one portion of an automobile tire with the drive wheel engaged at another portion of the automobile tire, and means to actuate the rotating means, so that with rotation of the drive wheel the automobile tire is rotated and the automobile and device moved along the ground.

  14. Rain sampling device

    DOEpatents

    Nelson, Danny A.; Tomich, Stanley D.; Glover, Donald W.; Allen, Errol V.; Hales, Jeremy M.; Dana, Marshall T.

    1991-01-01

    The present invention constitutes a rain sampling device adapted for independent operation at locations remote from the user which allows rainfall to be sampled in accordance with any schedule desired by the user. The rain sampling device includes a mechanism for directing wet precipitation into a chamber, a chamber for temporarily holding the precipitation during the process of collection, a valve mechanism for controllably releasing samples of said precipitation from said chamber, a means for distributing the samples released from the holding chamber into vessels adapted for permanently retaining these samples, and an electrical mechanism for regulating the operation of the device.

  15. Contamination sampling device

    NASA Technical Reports Server (NTRS)

    Delgado, Felix A. (Inventor); Stern, Susan M. (Inventor)

    1998-01-01

    A contamination sample collection device has a wooden dowel with a cotton swab at one end, the cotton being covered by a nylon cloth and the wooden dowel being encapsulated by plastic tubing which is heat shrunk onto the dowel and onto a portion of the cotton swab to secure the cotton in place. Another plastic tube is heat shrunk onto the plastic that encapsulates the dowel and a portion of the nylon cloth to secure the nylon cloth in place. The device may thereafter be covered with aluminum foil protector. The device may be used for obtaining samples of contamination in clean room environments.

  16. Corneal seal device

    NASA Technical Reports Server (NTRS)

    Baehr, E. F. (Inventor)

    1977-01-01

    A corneal seal device is provided which, when placed in an incision in the eye, permits the insertion of a surgical tool or instrument through the device into the eye. The device includes a seal chamber which opens into a tube which is adapted to be sutured to the eye and serves as an entry passage for a tool. A sealable aperture in the chamber permits passage of the tool through the chamber into the tube and hence into the eye. The chamber includes inlet ports adapted to be connected to a regulated source of irrigation fluid which provides a safe intraocular pressure.

  17. SLUG HANDLING DEVICES

    DOEpatents

    Gentry, J.R.

    1958-09-16

    A device is described for handling fuel elements of a neutronic reactor. The device consists of two concentric telescoped contalners that may fit about the fuel element. A number of ratchet members, equally spaced about the entrance to the containers, are pivoted on the inner container and spring biased to the outer container so thnt they are forced to hear against and hold the fuel element, the weight of which tends to force the ratchets tighter against the fuel element. The ratchets are released from their hold by raising the inner container relative to the outer memeber. This device reduces the radiation hazard to the personnel handling the fuel elements.

  18. Rain sampling device

    DOEpatents

    Nelson, D.A.; Tomich, S.D.; Glover, D.W.; Allen, E.V.; Hales, J.M.; Dana, M.T.

    1991-05-14

    The present invention constitutes a rain sampling device adapted for independent operation at locations remote from the user which allows rainfall to be sampled in accordance with any schedule desired by the user. The rain sampling device includes a mechanism for directing wet precipitation into a chamber, a chamber for temporarily holding the precipitation during the process of collection, a valve mechanism for controllably releasing samples of the precipitation from the chamber, a means for distributing the samples released from the holding chamber into vessels adapted for permanently retaining these samples, and an electrical mechanism for regulating the operation of the device. 11 figures.

  19. Introduction to Semiconductor Devices

    NASA Astrophysics Data System (ADS)

    Brennan, Kevin F.

    2005-03-01

    This volume offers a solid foundation for understanding the most important devices used in the hottest areas of electronic engineering today, from semiconductor fundamentals to state-of-the-art semiconductor devices in the telecommunications and computing industries. Kevin Brennan describes future approaches to computing hardware and RF power amplifiers, and explains how emerging trends and system demands of computing and telecommunications systems influence the choice, design and operation of semiconductor devices. In addition, he covers MODFETs and MOSFETs, short channel effects, and the challenges faced by continuing miniaturization. His book is both an excellent senior/graduate text and a valuable reference for practicing engineers and researchers.

  20. Purcell enhancement of fast-dephasing spontaneous emission from electron-hole droplets in high-Q silicon photonic crystal nanocavities

    NASA Astrophysics Data System (ADS)

    Sumikura, Hisashi; Kuramochi, Eiichi; Taniyama, Hideaki; Notomi, Masaya

    2016-11-01

    We have observed electron-hole droplet emission enhanced by silicon photonic crystal nanocavities with different Q values and simulated their Purcell effect using a semiclassical theory considering the temporal dephasing of the emission. When the photon loss rate of the nanocavities is smaller than the dephasing rate of the emission, the cavity-enhanced integrated photoluminescence (PL) intensity is unchanged by the cavity Q value. This is because the Purcell enhancement of the spontaneous emission rate is saturated in a high-Q region. In contrast, the peak intensity of the cavity-enhanced PL is proportional to the cavity Q value without saturation. These results suggest that a high-Q nanocavity is suitable for fabricating bright narrowband light emitting devices that concentrate the broadband emission energy of fast-dephasing emitters in a narrowband cavity resonance.

  1. Chronic Q Fever in the Netherlands 5 Years after the Start of the Q Fever Epidemic: Results from the Dutch Chronic Q Fever Database

    PubMed Central

    Delsing, Corine E.; Groenwold, Rolf H. H.; Wegdam-Blans, Marjolijn C. A.; Bleeker-Rovers, Chantal P.; de Jager-Leclercq, Monique G. L.; Hoepelman, Andy I. M.; van Kasteren, Marjo E.; Buijs, Jacqueline; Renders, Nicole H. M.; Nabuurs-Franssen, Marrigje H.; Oosterheert, Jan Jelrik; Wever, Peter C.

    2014-01-01

    Coxiella burnetii causes Q fever, a zoonosis, which has acute and chronic manifestations. From 2007 to 2010, the Netherlands experienced a large Q fever outbreak, which has offered a unique opportunity to analyze chronic Q fever cases. In an observational cohort study, baseline characteristics and clinical characteristics, as well as mortality, of patients with proven, probable, or possible chronic Q fever in the Netherlands, were analyzed. In total, 284 chronic Q fever patients were identified, of which 151 (53.7%) had proven, 64 (22.5%) probable, and 69 (24.3%) possible chronic Q fever. Among proven and probable chronic Q fever patients, vascular infection focus (56.7%) was more prevalent than endocarditis (34.9%). An acute Q fever episode was recalled by 27.0% of the patients. The all-cause mortality rate was 19.1%, while the chronic Q fever-related mortality rate was 13.0%, with mortality rates of 9.3% among endocarditis patients and 18% among patients with a vascular focus of infection. Increasing age (P = 0.004 and 0.010), proven chronic Q fever (P = 0.020 and 0.002), vascular chronic Q fever (P = 0.024 and 0.005), acute presentation with chronic Q fever (P = 0.002 and P < 0.001), and surgical treatment of chronic Q fever (P = 0.025 and P < 0.001) were significantly associated with all-cause mortality and chronic Q fever-related mortality, respectively. PMID:24599987

  2. Coupling Ideality of Integrated Planar High-Q Microresonators

    NASA Astrophysics Data System (ADS)

    Pfeiffer, Martin H. P.; Liu, Junqiu; Geiselmann, Michael; Kippenberg, Tobias J.

    2017-02-01

    Chip-scale optical microresonators with integrated planar optical waveguides are useful building blocks for linear, nonlinear, and quantum-optical photonic devices alike. Loss reduction through improving fabrication processes results in several integrated microresonator platforms attaining quality (Q ) factors of several millions. Beyond the improvement of the quality factor, the ability to operate the microresonator with high coupling ideality in the overcoupled regime is of central importance. In this regime, the dominant source of loss constitutes the coupling to a single desired output channel, which is particularly important not only for quantum-optical applications such as the generation of squeezed light and correlated photon pairs but also for linear and nonlinear photonics. However, to date, the coupling ideality in integrated photonic microresonators is not well understood, in particular, design-dependent losses and their impact on the regime of high ideality. Here we investigate design-dependent parasitic losses described by the coupling ideality of the commonly employed microresonator design consisting of a microring-resonator waveguide side coupled to a straight bus waveguide, a system which is not properly described by the conventional input-output theory of open systems due to the presence of higher-order modes. By systematic characterization of multimode high-Q silicon nitride microresonator devices, we show that this design can suffer from low coupling ideality. By performing 3D simulations, we identify the coupling to higher-order bus waveguide modes as the dominant origin of parasitic losses which lead to the low coupling ideality. Using suitably designed bus waveguides, parasitic losses are mitigated with a nearly unity ideality and strong overcoupling (i.e., a ratio of external coupling to internal resonator loss rate >9 ) are demonstrated. Moreover, we find that different resonator modes can exchange power through the coupler, which, therefore

  3. Q Fever Outbreak in Industrial Setting

    PubMed Central

    Mason, Brendan W.; Nehaul, Lika K.; Smith, Robert; Salmon, Roland L.; Healy, Brendan; Valappil, Manoj; Westmoreland, Diana; de Martin, Sarah; Evans, Meirion R.; Lloyd, Graham; Hamilton-Kirkwood, Marysia; Williams, Nina S.

    2004-01-01

    An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. Ninety-five cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred August 5–9, 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38–9.06). The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board. PMID:15324550

  4. Q|R: quantum-based refinement.

    PubMed

    Zheng, Min; Reimers, Jeffrey R; Waller, Mark P; Afonine, Pavel V

    2017-01-01

    Quantum-based refinement utilizes chemical restraints derived from quantum-chemical methods instead of the standard parameterized library-based restraints used in refinement packages. The motivation is twofold: firstly, the restraints have the potential to be more accurate, and secondly, the restraints can be more easily applied to new molecules such as drugs or novel cofactors. Here, a new project called Q|R aimed at developing quantum-based refinement of biomacromolecules is under active development by researchers at Shanghai University together with PHENIX developers. The central focus of this long-term project is to develop software that is built on top of open-source components. A development version of Q|R was used to compare quantum-based refinements with standard refinement using a small model system.

  5. Millimeter wave I-Q standoff biosensor

    NASA Astrophysics Data System (ADS)

    Liao, Shaolin; Bakhtiari, Sasan; Elmer, Thomas; Raptis, Apostolos C.; Mikhelson, Ilya V.; Sahakian, Alan V.

    2012-06-01

    A continuous wave (CW) 94-GHz millimeter wave (mmW) standoff biosensor has been developed for remote biometric sensing applications. The sensor measures the demodulated in-phase (I) and quadrature-phase (Q) components of the received reflected mmW signal from a subject. Both amplitude and phase of the reflected signal are obtained from downconverted I and Q channels from the quadrature mixer. The mmW sensor can faithfully monitor human vital signs (heartbeat and respiration) at relatively long standoff distances. Principle Component Analysis (PCA) is used to extract the heartbeat, the respiration and the body motion signals. The approach allows one to deduce information about amplitude and beat-to-beat rate of the respiration and the heartbeat. Experimental results collected from a subject were analyzed and compared to the signal obtained with a three-electrode ECG monitoring instrument.

  6. Hypoplastic Left Heart Syndrome Links to Chromosomes 10q and 6q and Is Genetically Related to Bicuspid Aortic Valve

    PubMed Central

    Hinton, Robert B.; Martin, Lisa J.; Rame-Gowda, Smitha; Tabangin, Meredith E.; Cripe, Linda H.; Benson, D. Woodrow

    2009-01-01

    Objectives This study was designed to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic relationship between HLHS and bicuspid aortic valve (BAV). Background Previously, we identified that HLHS and BAV exhibit complex inheritance, and both HLHS and BAV kindreds are enriched for BAV. However, the genetic basis of HLHS and its relationship to BAV remains unclear. Methods Family-based nonparametric genome-wide linkage analysis was performed in kindreds ascertained by either an HLHS or BAV proband. Echocardiograms were performed on 1,013 participants using a sequential sampling strategy (33 HLHS kindreds, 102 BAV kindreds). Results The recurrence risk ratio of BAV in HLHS families (8.05) was nearly identical to that in BAV families (8.77). Linkage to chromosomal regions 10q22 and 6q23 with maximum logarithm of odds scores of 3.2 and 3.1, respectively, was identified in HLHS kindreds. In addition, 5 suggestive loci were identified (7q31, 11q22, 12q13, 14q23, and 20q11). We previously identified loci at chromosomes 18q22, 13q34, and 5q21 in BAV kindreds. The relationship between these loci was examined in the combined HLHS and BAV cohort and associations between loci were demonstrated (5q21, 13q34, and 14q23; 6q23 and 10q22; 7q31 and 20q11). Subsequent subsets linkage analysis showed a significant improvement in the logarithm of odds score at 14q23 only (4.1, p < 0.0001). Conclusions These studies demonstrate linkage to multiple loci identifying HLHS as genetically heterogeneous. Subsets linkage analyses and recurrence risk ratios in a combined cohort provide evidence that some HLHS and BAV are genetically related. PMID:19298921

  7. Q-Flex Accelerometer Thermal Performance Study

    DTIC Science & Technology

    1976-09-01

    bridge between the sensor assembly and its stainless steel cover have been retained. Mounting Flange Stress- The Q-Flex mounting flange is flat when...Flex accelerometer are entirely stainless steel , except for the solder-plated pins and glass of the unit header. There are no maintenance schedules...or considered on development systems such as ATIGS and RCG. f^\\ With the aforementioned systems, where the Ring Laser Gyro provides "instant-on

  8. [Q fever. Description of a case].

    PubMed

    Peña-Irún, Á; González Santamaría, A R; Munguía Rozadilla, F; Herrero González, J L

    2013-01-01

    Q fever is a zoonosis of global distribution with an incidence of 3 cases per 100,000 inhabitants/year. A variety of animals can be the coxiella reservoir which always must be taken into account when faced with a fever process in a compatible context. Rapid diagnosis and treatment are essential to improve the prognosis, and prevent the development of chronic infection or other potential complications associated with the coxelliosis.

  9. Genomic disorders on 22q11.

    PubMed

    McDermid, Heather E; Morrow, Bernice E

    2002-05-01

    The 22q11 region is involved in chromosomal rearrangements that lead to altered gene dosage, resulting in genomic disorders that are characterized by mental retardation and/or congenital malformations. Three such disorders-cat-eye syndrome (CES), der(22) syndrome, and velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS)-are associated with four, three, and one dose, respectively, of parts of 22q11. The critical region for CES lies centromeric to the deletion region of VCFS/DGS, although, in some cases, the extra material in CES extends across the VCFS/DGS region. The der(22) syndrome region overlaps both the CES region and the VCFS/DGS region. Molecular approaches have revealed a set of common chromosome breakpoints that are shared between the three disorders, implicating specific mechanisms that cause these rearrangements. Most VCFS/DGS and CES rearrangements are likely to occur by homologous recombination events between blocks of low-copy repeats (e.g., LCR22), whereas nonhomologous recombination mechanisms lead to the constitutional t(11;22) translocation. Meiotic nondisjunction events in carriers of the t(11;22) translocation can then lead to offspring with der(22) syndrome. The molecular basis of the clinical phenotype of these genomic disorders has also begun to be addressed. Analysis of both the genomic sequence for the 22q11 interval and the orthologous regions in the mouse has identified >24 genes that are shared between VCFS/DGS and der(22) syndrome and has identified 14 putative genes that are shared between CES and der(22) syndrome. The ability to manipulate the mouse genome aids in the identification of candidate genes in these three syndromes. Research on genomic disorders on 22q11 will continue to expand our knowledge of the mechanisms of chromosomal rearrangements and the molecular basis of their phenotypic consequences.

  10. Q-Ships of the Great War

    DTIC Science & Technology

    2000-04-01

    commanded by Lieutenant Commander Godfrey Herbert, an ex-submariner considered by many to be a maverick for his unconventional methods, roistering...Review 22(7):26-40. Bennett, Geoffrey . 1968. Naval Battles of the First World War. New York: Charles Scribner‘s Sons. Beyer, Kenneth M. 1999. Q...War I. Annapolis, Maryland: Naval Institute Press. Hattendorf, John B., Knight, R.J.B., Pearsall, A.W.H., Rodger, N.A.M., and Till, Geoffrey . 1993

  11. Q-Bursts: Natural ELF Radio Transients

    NASA Astrophysics Data System (ADS)

    Nickolaenko, A. P.; Hayakawa, M.; Hobara, Y.

    2010-07-01

    We overview resonance spectra and present analytical expressions for the waveforms of natural extremely low frequency transient events (Q-bursts). It is shown that model and observed waveforms are similar when a wideband receiver is used at a place with low level of industrial interference. We also describe how to detect a natural ELF transient signal embedded in the man-made noise by using the singular spectral analysis.

  12. The Rebirth of D-Q University

    ERIC Educational Resources Information Center

    Valdata, Patricia

    2006-01-01

    The Phoenix is a traditional symbol of rebirth, but for D-Q University, a bolt cutter may be a more appropriate image. After more than 30 years as California's only two-year tribal college, the school lost its accreditation in January 2005. The board of directors tried to keep the school open, but last summer they began packing up student records,…

  13. Physical Review X Q&A Session

    NASA Astrophysics Data System (ADS)

    2014-03-01

    Physical Review X (PRX) is already being recognized as a top-quality journal in physics. What are its current standards and strengths? How will it grow and evolve in the coming years? Why is PRX a journal for you? PRX editors and the Editorial Board invite you to a Q & A session, where we will answer these questions and others you have about the journal. Bring your questions and learn more about PRX. Light refreshments will be provided.

  14. Multiple acousto-optic q-switch

    DOEpatents

    Deason, Vance A.

    1993-01-01

    An improved dynamic moire interferometer comprised of a lasing medium providing a plurality of beams of coherent light, a multiple q-switch producing multiple trains of 100,000 or more pulses per second, a combining means collimating multiple trains of pulses into substantially a single train and directing beams to specimen gratings affixed to a test material, and a controller, triggering and sequencing the emission of the pulses with the occurrence and recording of a dynamic loading event.

  15. Multiple acousto-optic q-switch

    DOEpatents

    Deason, Vance A.

    1993-12-07

    An improved dynamic moire interferometer comprised of a lasing medium providing a plurality of beams of coherent light, a multiple q-switch producing multiple trains of 100,000 or more pulses per second, a combining means collimating multiple trains of pulses into substantially a single train and directing beams to specimen gratings affixed to a test material, and a controller, triggering and sequencing the emission of the pulses with the occurrence and recording of a dynamic loading event.

  16. 22q11.2 deletion syndrome

    PubMed Central

    McDonald-McGinn, Donna M.; Sullivan, Kathleen E.; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A. S.; Zackai, Elaine H.; Emanuel, Beverly S.; Vermeesch, Joris R.; Morrow, Bernice E.; Scambler, Peter J.; Bassett, Anne S.

    2016-01-01

    22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness — all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population. PMID:27189754

  17. Degradation of AF1Q by chaperone-mediated autophagy

    SciTech Connect

    Li, Peng; Ji, Min; Lu, Fei; Zhang, Jingru; Li, Huanjie; Cui, Taixing; Li Wang, Xing; Tang, Dongqi; Ji, Chunyan

    2014-09-10

    AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid leukemia (AML), adult AML with normal cytogenetic and adult myelodysplastic syndrome. AF1Q is highly regulated during hematopoietic progenitor differentiation and development but its regulatory mechanism has not been defined clearly. In the present study, we used pharmacological and genetic approaches to influence chaperone-mediated autophagy (CMA) and explored the degradation mechanism of AF1Q. Pharmacological inhibitors of lysosomal degradation, such as chloroquine, increased AF1Q levels, whereas activators of CMA, including 6-aminonicotinamide and nutrient starvation, decreased AF1Q levels. AF1Q interacts with HSPA8 and LAMP-2A, which are core components of the CMA machinery. Knockdown of HSPA8 or LAMP-2A increased AF1Q protein levels, whereas overexpression showed the opposite effect. Using an amino acid deletion AF1Q mutation plasmid, we identified that AF1Q had a KFERQ-like motif which was recognized by HSPA8 for CMA-dependent proteolysis. In conclusion, we demonstrate for the first time that AF1Q can be degraded in lysosomes by CMA. - Highlights: • Chaperone-mediated autophagy (CMA) is involved in the degradation of AF1Q. • Macroautophagy does not contribute to the AF1Q degradation. • AF1Q has a KFERQ-like motif that is recognized by CMA core components.

  18. Searching for Q-balls with HAWC

    NASA Astrophysics Data System (ADS)

    Karn, Peter

    2013-04-01

    The High Altitude Water Cherenkov (HAWC) Observatory is a gamma-ray experiment currently under construction at Sierra Negra in the state of Puebla, Mexico. Once completed, it will consist of a 20,000 square meter array of 300 water Cherenkov detectors. Although the HAWC Observatory is designed to study gamma rays from galactic and extra-galactic sources, the large instrumented volume of water gives the opportunity to search for more exotic species. One such target, predicted by several varieties of supersymmetric theory, is the Q-ball. Q-balls are very massive, sub-relativistic particles that can have a large baryon number, and can be stable since their creation in the early universe. They are also an appealing candidate for the dark matter of the universe, but their large masses must mean that their flux is very low. The data acquisition system of the HAWC Observatory is flexible enough that, with a dedicated trigger algorithm for non-relativistic particles, it allows the search for Q-balls traversing the detector. The trigger algorithm and preliminary analysis will be presented.

  19. THE Q/U IMAGING EXPERIMENT INSTRUMENT

    SciTech Connect

    Bischoff, C.; Brizius, A.; Buder, I.; Kusaka, A.; Smith, K. M.; Bogdan, M.; Chinone, Y.; Cleary, K.; Reeves, R.; Monsalve, R.; Bustos, R.; Naess, S. K.; Nixon, G.; Vanderlinde, K.; Wehus, I. K.; Church, S. E.; Davis, R.; Dickinson, C.; and others

    2013-05-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the cosmic microwave background, targeting the imprint of inflationary gravitational waves at large angular scales({approx}1 Degree-Sign ). Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4 m side-fed Dragonian telescope. The polarimeters that form the focal planes use a compact design based on high electron mobility transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 {mu}Ks{sup 1/2}) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0.1. The 84-element W-band polarimeter array has a sensitivity of 87 {mu}Ks{sup 1/2} at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0.01. The two arrays together cover multipoles in the range l {approx} 25-975. These are the largest HEMT-based arrays deployed to date. This article describes the design, calibration, performance, and sources of systematic error of the instrument.

  20. Ytterbium-doped Q-switched fiber laser based upon manganese dioxide (MnO2) saturable absorber.

    PubMed

    Hattori, Haroldo T; Khaleque, Abdul; Liu, Liming; Greck, Michael R

    2016-11-10

    Manganese dioxide (MnO2) is an abundant material that is widely used in many devices, such as alkaline batteries. At infrared frequencies, MnO2 is lossy and strongly absorbs light. These characteristics make MnO2 a potential candidate as a low-cost saturable absorber in Q-switched lasers. In this paper, we examine the performance of MnO2 as a saturable absorber in an ytterbium-doped Q-switched fiber laser: we show that it can produce pulses with durations ranging from 300 to 1800 ns.

  1. Thermoelectric materials and devices

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); Choi, Sang H. (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor); Talcott, Noel A. (Inventor)

    2011-01-01

    New thermoelectric materials comprise highly [111]-oriented twinned group IV alloys on the basal plane of trigonal substrates, which exhibit a high thermoelectric figure of merit and good material performance, and devices made with these materials.

  2. Adhesion testing device

    NASA Technical Reports Server (NTRS)

    LaPeyronnie, Glenn M. (Inventor); Huff, Charles M. (Inventor)

    2010-01-01

    The present invention provides a testing apparatus and method for testing the adhesion of a coating to a surface. The invention also includes an improved testing button or dolly for use with the testing apparatus and a self aligning button hook or dolly interface on the testing apparatus. According to preferred forms, the apparatus and method of the present invention are simple, portable, battery operated rugged, and inexpensive to manufacture and use, are readily adaptable to a wide variety of uses, and provide effective and accurate testing results. The device includes a linear actuator driven by an electric motor coupled to the actuator through a gearbox and a rotatable shaft. The electronics for the device are contained in the head section of the device. At the contact end of the device, is positioned a self aligning button hook, attached below the load cell located on the actuator shaft.

  3. Blood Glucose Monitoring Devices

    MedlinePlus

    ... is to use pain associated with using the product testing speed overall size ability to store test results ... Areas back Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products

  4. Marine Sanitation Devices (MSDs)

    EPA Pesticide Factsheets

    Marine sanitation devices treat or retain sewage from vessels, and have performance standards set by the EPA. This page provides information on MSDs, including who must use an MSD, states' roles, types of MSDs and standards.

  5. Devices for hearing loss

    MedlinePlus

    ... sounds, such as the doorbell or a ringing phone. They can also alert you to things happening ... telephone. Devices called amplifiers make sound louder. Some phones have amplifiers built-in. You can also attach ...

  6. Water-walking devices

    NASA Astrophysics Data System (ADS)

    Hu, David L.; Prakash, Manu; Chan, Brian; Bush, John W. M.

    2007-11-01

    We report recent efforts in the design and construction of water-walking machines inspired by insects and spiders. The fundamental physical constraints on the size, proportion and dynamics of natural water-walkers are enumerated and used as design criteria for analogous mechanical devices. We report devices capable of rowing along the surface, leaping off the surface and climbing menisci by deforming the free surface. The most critical design constraint is that the devices be lightweight and non-wetting. Microscale manufacturing techniques and new man-made materials such as hydrophobic coatings and thermally actuated wires are implemented. Using high-speed cinematography and flow visualization, we compare the functionality and dynamics of our devices with those of their natural counterparts.

  7. Development of electrochromic devices.

    PubMed

    Pawlicka, A

    2009-01-01

    Electrochromic devices (ECD) are systems of considerable commercial interest due to their controllable transmission, absorption and/or reflectance. For instance, these devices are mainly applied to glare attenuation in automobile rearview mirrors and also in some smart windows that can regulate the solar gains of buildings. Other possible applications of ECDs include solar cells, small- and large-area flat panel displays, and frozen food monitoring and document authentication also are of great interest. Over the past 20 years almost 1000 patents and 1500 papers in journals and proceedings have been published with the key words "electrochromic windows". Most of these documents report on materials for electrochromic devices and only some of them about complete electrochromic devices. This paper describes the first patents and some of the recent ones on ECDs, whose development is possible due to the advances in nanotechnology.

  8. External incontinence devices

    MedlinePlus

    ... devices have a drainable pouch attached to an adhesive wafer. This wafer has a hole cut through ... medicines and disposable garments such as Depends. The systems for men most often consist of a pouch ...

  9. Advanced underwater lift device

    NASA Technical Reports Server (NTRS)

    Flanagan, David T.; Hopkins, Robert C.

    1993-01-01

    Flexible underwater lift devices ('lift bags') are used in underwater operations to provide buoyancy to submerged objects. Commercially available designs are heavy, bulky, and awkward to handle, and thus are limited in size and useful lifting capacity. An underwater lift device having less than 20 percent of the bulk and less than 10 percent of the weight of commercially available models was developed. The design features a dual membrane envelope, a nearly homogeneous envelope membrane stress distribution, and a minimum surface-to-volume ratio. A proof-of-concept model of 50 kg capacity was built and tested. Originally designed to provide buoyancy to mock-ups submerged in NASA's weightlessness simulators, the device may have application to water-landed spacecraft which must deploy flotation upon impact, and where launch weight and volume penalties are significant. The device may also be useful for the automated recovery of ocean floor probes or in marine salvage applications.

  10. Microreactor Array Device

    NASA Astrophysics Data System (ADS)

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; Labaer, Joshua

    2015-03-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented.

  11. Head Impact Measurement Devices.

    PubMed

    Williams, Richelle M; Dowling, Margaret; O'Connor, Kathryn L

    Concussive injuries are at the forefront of sports medicine research. Recently, researchers have used a variety of head- and helmet-based impact-monitoring devices to quantify impacts sustained during contact sport participation. This review provides an up-to-date collection of head accelerometer use at the youth, high school, and collegiate levels. PubMed was searched for articles published between 1980 and 2015 using the terms accelerometer and concussion, impact sensor and concussion, head impact telemetry system, head impact telemetry, and linear acceleration and concussion. An additional Google search was performed to capture devices without publications. Clinical review. Level 4. Twenty-four products track and/or record head impact for clinical or research use. Ten of these head impact devices have publications supporting their utility. Head impact measuring devices can describe athlete exposure in terms of magnitude and/or frequency, highlighting their utility within a multimodal approach for concussion assessment and diagnosis.

  12. Devices for Arrhythmia

    MedlinePlus

    ... Disease Venous Thromboembolism Aortic Aneurysm More Devices for Arrhythmia Updated:Dec 21,2016 In a medical emergency, ... This content was last reviewed September 2016. Printable Arrhythmia Information Sheets What is Arrhythmia? What is Atrial ...

  13. Geometry and Cloaking Devices

    NASA Astrophysics Data System (ADS)

    Ochiai, T.; Nacher, J. C.

    2011-09-01

    Recently, the application of geometry and conformal mappings to artificial materials (metamaterials) has attracted the attention in various research communities. These materials, characterized by a unique man-made structure, have unusual optical properties, which materials found in nature do not exhibit. By applying the geometry and conformal mappings theory to metamaterial science, it may be possible to realize so-called "Harry Potter cloaking device". Although such a device is still in the science fiction realm, several works have shown that by using such metamaterials it may be possible to control the direction of the electromagnetic field at will. We could then make an object hidden inside of a cloaking device. Here, we will explain how to design invisibility device using differential geometry and conformal mappings.

  14. Optical devices: A compilation

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Technological developments in the field of optics devices which have potential utility outside the aerospace community are described. Optical instrumentation, light generation and transmission, and laser techniques are among the topics covered. Patent information is given.

  15. Ferroelectric Light Control Device

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); Choi, Sang H. (Inventor); King, Glen C. (Inventor); Kim, Jae-Woo (Inventor); Elliott, Jr., James R. (Inventor)

    2008-01-01

    A light control device is formed by ferroelectric material and N electrodes positioned adjacent thereto to define an N-sided regular polygonal region or circular region there between where N is a multiple of four.

  16. Microreactor Array Device

    PubMed Central

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; LaBaer, Joshua

    2015-01-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented. PMID:25736721

  17. Dielectrophoretically tunable optofluidic devices

    NASA Astrophysics Data System (ADS)

    Xu, Su; Ren, Hongwen; Wu, Shin-Tson

    2013-12-01

    Tunable optofluidic devices exhibit some unique characteristics that are not achievable in conventional solid-state photonic devices. They provide exciting opportunities for emerging applications in imaging, information processing, sensing, optical communication, lab-on-a-chip and biomedical engineering. A dielectrophoresis effect is an important physical mechanism to realize tunable optofluidic devices. Via balancing the voltage-induced dielectric force and interfacial tension, the liquid interface can be dynamically manipulated and the optical output reconfigured or adaptively tuned in real time. Dielectrophoretically tunable optofluidic devices offer several attractive features, such as rapid prototyping, miniaturization, easy integration and low power consumption. In this review paper, we first explain the underlying operation principles and then review some recent progress in this field, covering the topics of adaptive lens, beam steering, iris, grating, optical switch/attenuator and single pixel display. Finally, the future perspectives are discussed.

  18. Intrauterine device (image)

    MedlinePlus

    ... uses copper as the active contraceptive, others use progesterone in a plastic device. IUDs are very effective ... less than 2% chance per year for the progesterone IUD, less than 1% chance per year for ...

  19. Authenticated sensor interface device

    SciTech Connect

    Coleman, Jody Rustyn; Poland, Richard W.

    2016-10-18

    A system and method for the secure storage and transmission of data is provided. A data aggregate device can be configured to receive secure data from a data source, such as a sensor, and encrypt the secure data using a suitable encryption technique, such as a shared private key technique, a public key encryption technique, a Diffie-Hellman key exchange technique, or other suitable encryption technique. The encrypted secure data can be provided from the data aggregate device to different remote devices over a plurality of segregated or isolated data paths. Each of the isolated data paths can include an optoisolator that is configured to provide one-way transmission of the encrypted secure data from the data aggregate device over the isolated data path. External data can be received through a secure data filter which, by validating the external data, allows for key exchange and other various adjustments from an external source.

  20. Water-walking devices

    NASA Astrophysics Data System (ADS)

    Hu, David L.; Prakash, Manu; Chan, Brian; Bush, John W. M.

    We report recent efforts in the design and construction of water-walking machines inspired by insects and spiders. The fundamental physical constraints on the size, proportion and dynamics of natural water-walkers are enumerated and used as design criteria for analogous mechanical devices. We report devices capable of rowing along the surface, leaping off the surface and climbing menisci by deforming the free surface. The most critical design constraint is that the devices be lightweight and non-wetting. Microscale manufacturing techniques and new man-made materials such as hydrophobic coatings and thermally actuated wires are implemented. Using highspeed cinematography and flow visualization, we compare the functionality and dynamics of our devices with those of their natural counterparts.

  1. Slit injection device

    DOEpatents

    Alger, Terry W.; Schlitt, Leland G.; Bradley, Laird P.

    1976-06-15

    A laser cavity electron beam injection device provided with a single elongated slit window for passing a suitably shaped electron beam and means for varying the current density of the injected electron beam.

  2. High temperature measuring device

    DOEpatents

    Tokarz, Richard D.

    1983-01-01

    A temperature measuring device for very high design temperatures (to 2,000.degree. C.). The device comprises a homogenous base structure preferably in the form of a sphere or cylinder. The base structure contains a large number of individual walled cells. The base structure has a decreasing coefficient of elasticity within the temperature range being monitored. A predetermined quantity of inert gas is confined within each cell. The cells are dimensionally stable at the normal working temperature of the device. Increases in gaseous pressure within the cells will permanently deform the cell walls at temperatures within the high temperature range to be measured. Such deformation can be correlated to temperature by calibrating similarly constructed devices under known time and temperature conditions.

  3. Implantable Medical Devices

    MedlinePlus

    ... a Heart Attack Treatment of a Heart Attack Life After a Heart Attack Heart Failure About Heart Failure ... Attack Introduction Medications Surgical Procedures Implantable Medical Devices • Life After a Heart Attack • Heart Attack Tools & Resources • Support ...

  4. Single molecule electronic devices.

    PubMed

    Song, Hyunwook; Reed, Mark A; Lee, Takhee

    2011-04-12

    Single molecule electronic devices in which individual molecules are utilized as active electronic components constitute a promising approach for the ultimate miniaturization and integration of electronic devices in nanotechnology through the bottom-up strategy. Thus, the ability to understand, control, and exploit charge transport at the level of single molecules has become a long-standing desire of scientists and engineers from different disciplines for various potential device applications. Indeed, a study on charge transport through single molecules attached to metallic electrodes is a very challenging task, but rapid advances have been made in recent years. This review article focuses on experimental aspects of electronic devices made with single molecules, with a primary focus on the characterization and manipulation of charge transport in this regime. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Gelatin in electrochromic devices

    NASA Astrophysics Data System (ADS)

    Silva, M. M.; Barbosa, P. C.; Rodrigues, L. C.; Gonçalves, A.; Costa, C.; Fortunato, E.

    2010-04-01

    A gelatin-based electrolyte has been developed and characterized by impedance spectroscopy and thermal analysis. These electrolytes are promising materials to be applied in electrochromic devices because gelatine is a material available in nature, it is cheap, easy to handle and to prepare. In this study the characterization of a solid-state electrochromic device based on gelatin is reported and results obtained suggest that this electrolyte is very attractive for electrochemical device applications. Gelatin-based electrolytes were successfully used in the assembly of prototype electrochromic devices (ECDs) and exhibited good optical density. The ECD display incorporating gelatine I and gelatine II samples presented in the visible region an average transmittance above 68% in the bleached state. After coloration the structure assembled with gelatine I composition presented an average transmittance in the visible wavelength region above 21% and 36% for gelatin II.

  6. Nanowire Thermoelectric Devices

    NASA Technical Reports Server (NTRS)

    Borshchevsky, Alexander; Fleurial, Jean-Pierre; Herman, Jennifer; Ryan, Margaret

    2005-01-01

    Nanowire thermoelectric devices, now under development, are intended to take miniaturization a step beyond the prior state of the art to exploit the potential advantages afforded by shrinking some device features to approximately molecular dimensions (of the order of 10 nm). The development of nanowire-based thermoelectric devices could lead to novel power-generating, cooling, and sensing devices that operate at relatively low currents and high voltages. Recent work on the theory of thermoelectric devices has led to the expectation that the performance of such a device could be enhanced if the diameter of the wires could be reduced to a point where quantum confinement effects increase charge-carrier mobility (thereby increasing the Seebeck coefficient) and reduce thermal conductivity. In addition, even in the absence of these effects, the large aspect ratios (length of the order of tens of microns diameter of the order of tens of nanometers) of nanowires would be conducive to the maintenance of large temperature differences at small heat fluxes. The predicted net effect of reducing diameters to the order of tens of nanometers would be to increase its efficiency by a factor of .3. Nanowires made of thermoelectric materials and devices that comprise arrays of such nanowires can be fabricated by electrochemical growth of the thermoelectric materials in templates that contain suitably dimensioned pores (10 to 100 nm in diameter and 1 to 100 microns long). The nanowires can then be contacted in bundles to form devices that look similar to conventional thermoelectric devices, except that a production version may contain nearly a billion elements (wires) per square centimeter, instead of fewer than a hundred as in a conventional bulk thermoelectric device or fewer than 100,000 as in a microdevice. It is not yet possible to form contacts with individual nanowires. Therefore, in fabricating a nanowire thermoelectric device, one forms contacts on nanowires in bundles of the

  7. A compact and efficient four-wavelength Q-switched Nd:YAP laser

    NASA Astrophysics Data System (ADS)

    Huang, C. H.; Zhang, G.; Wei, Y.; Zhu, H. Y.; Huang, L. X.

    2010-04-01

    In this paper, a four-wavelength electro-optic (E-O) Q-switched solid-state laser system was presented. This laser system only use one Nd:YAP laser crystal, which irradiates 1079.5 nm and 1341.4 nm fundamental wavelengths. Both of these wavelength lasers and their second harmonic generation (SHG) compose a four-wavelength Nd:YAP Q-switched laser. The Q-switched output energies of 277 mJ for 1079.5 nm and 61 mJ for 539.8 nm and that of 190 mJ for 1341.4 nm and 51 mJ for 670.7 nm wavelengths were achieved. The pulse durations of 1079.5 and 539.8 nm lasers and that of 1341.4 and 670.7 nm lasers are 20 and 40 ns, respectively. Due to this laser system has the larger chance and convenience for selecting the wavelengths and operation modes by moving a stepping motor and controlling the Q-switched devices, it will broaden applications in the fields of laser cosmetology, dermatotis therapy, material processing and laser display etc.

  8. High-Q plasmonic infrared absorber for sensing of molecular resonances in hybrid lead halide perovskites

    NASA Astrophysics Data System (ADS)

    Dayal, Govind; Solanki, Ankur; Yu Chin, Xin; Sum, Tze Chien; Soci, Cesare; Singh, Ranjan

    2017-08-01

    Plasmonic resonances in sub-wavelength metal-dielectric-metal cavities have been shown to exhibit strong optical field enhancement. The large field enhancements that occur in sub-wavelength regions of the cavity can drastically boost the performance of microcavity based detectors, electromagnetic wave absorbers, metasurface hologram, and nonlinear response of the material in a cavity. The performance efficiencies of these plasmonic devices can be further improved by designing tunable narrow-band high-Q cavities. Here, we experimentally and numerically demonstrate high-Q resonances in metal-dielectric-metal cavity consisting of an array of conductively coupled annular and rectangular apertures separated from the bottom continuous metal film by a thin dielectric spacer. Both, the in-plane and out of plane coupling between the resonators and the continuous metal film have been shown to support fundamental and higher order plasmonic resonances which result in high-Q response at mid-infrared frequencies. As a sensor application of the high-Q cavity, we sense the vibrational resonances of an ultrathin layer of solution-processed organic-inorganic hybrid lead halide perovskites.

  9. Wireless device monitoring systems and monitoring devices, and associated methods

    DOEpatents

    McCown, Steven H; Derr, Kurt W; Rohde, Kenneth W

    2014-05-27

    Wireless device monitoring systems and monitoring devices include a communications module for receiving wireless communications of a wireless device. Processing circuitry is coupled with the communications module and configured to process the wireless communications to determine whether the wireless device is authorized or unauthorized to be present at the monitored area based on identification information of the wireless device. Methods of monitoring for the presence and identity of wireless devices are also provided.

  10. Electrochromic Display Device

    DTIC Science & Technology

    1976-04-01

    an electrochromic device consisting of: Glass - SnO / EC / EC / Metal where EC. is a known electrochromic material such as WO^ or MoO and EC_ is...PROTECTIVE COATING -COUNTER ELECTRODE -INSULATOR ELECTROCHROMIC TRANSPARENT CONDUCTOR GLASS FUNCTION GEN. MONOCHROMATIC LIGHT SOURCE hV ■C...DOCUMENTATION PAGE 2. GOVT ACCfcSSION NO RBAO 1NSTKUCTK)NS HKIOKK COMPLETINO FORM 3 RECIPIKNT’S CATALOG NUMBER ELECTROCHROMIC DISPUY DEVICE

  11. Nitinol Temperature Monitoring Devices

    DTIC Science & Technology

    1976-01-09

    AD-A021 578 NITINOL TEMPERATURE MONITORING DEVICES William J. Buehler, et al Naval Surface Weapons Center Silver Spring, Maryland 9 January 1976...LABORATORY S NITINOL TEMPERATURE MONITORING DEVICES 9 JANUARY 1976 NAVAL SURFACE WEAPONS CENTER WHITE OAK LABORATORY SILVER SPRING, MARYLAND 20910 * Approved...GOVT ACCESSION NO. 3. RECIPIIENT’S CATALOG NUMBER NSWC/WOL/TR 75-140 ____ ______ 4 TITLE (and Subtitle) 5. TYPE OF REPCRT & PERIOD COVERED Nitinol

  12. Biomaterials and Biomedical Devices

    NASA Astrophysics Data System (ADS)

    Hanker, Jacob S.; Giammara, Beverly L.

    1988-11-01

    This review discusses the factors important in the incorporation or integration of biomaterials and devices by tissue. Methods for surface modification and surface-sensitive techniques for analysis are cited. In vitro methods to evaluate the biocompatibility or efficacy of certain biomaterials and devices are presented. Present and future directions in neural prostheses, cardiovascular materials, blood or bone substitutes, controlled drug delivery, orthopedic prostheses, dental materials, artificial organs, plasma- and cytapheresis, and dialysis are discussed.

  13. Atherectomy devices: technology update

    PubMed Central

    Akkus, Nuri I; Abdulbaki, Abdulrahman; Jimenez, Enrique; Tandon, Neeraj

    2015-01-01

    Atherectomy is a procedure which is performed to remove atherosclerotic plaque from diseased arteries. Atherosclerotic plaques are localized in either coronary or peripheral arterial vasculature and may have different characteristics depending on the texture of the plaque. Atherectomy has been used effectively in treatment of both coronary and peripheral arterial disease. Atherectomy devices are designed differently to either cut, shave, sand, or vaporize these plaques and have different indications. In this article, current atherectomy devices are reviewed. PMID:25565904

  14. The intrauterine contraceptive device.

    PubMed Central

    Barwin, B. N.; Tuttle, S.; Jolly, E. E.

    1978-01-01

    This presentation brings into perspective the most recent information on intrauterine contraceptive devices. A comprehensive review of the literature is presented in a manner meaningful to the clinician. The advantages and disadvantages of this method of contraception, the problems that arise and the recommended methods of management are discussed. An updated review of the literature with regard to bleeding, pain, expulsion of the device, infection, uterine perforation and pregnancy is also presented. PMID:620385

  15. Inverted organic photosensitive device

    DOEpatents

    Forrest, Stephen R.; Tong, Xiaoran; Lee, Jun Yeob; Cho, Yong Joo

    2015-09-08

    There is disclosed a method for preparing the surface of a metal substrate. The present disclosure also relates to an organic photovoltaic device including a metal substrate made by such method. Also disclosed herein is an inverted photosensitive device including a stainless steel foil reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode over the donor-acceptor heterojunction.

  16. Commercialization of microfluidic devices.

    PubMed

    Volpatti, Lisa R; Yetisen, Ali K

    2014-07-01

    Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited diffusion into consumer products. This article analyzes the microfluidics market, identifies issues, and highlights successful commercialization strategies. Addressing niche markets and establishing compatibility with existing workflows will accelerate market penetration. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Raney nickel catalytic device

    DOEpatents

    O'Hare, Stephen A.

    1978-01-01

    A catalytic device for use in a conventional coal gasification process which includes a tubular substrate having secured to its inside surface by expansion a catalytic material. The catalytic device is made by inserting a tubular catalytic element, such as a tubular element of a nickel-aluminum alloy, into a tubular substrate and heat-treating the resulting composite to cause the tubular catalytic element to irreversibly expand against the inside surface of the substrate.

  18. Exhaust gas purification device

    SciTech Connect

    Fujiwara, H.; Hibi, T.; Sayo, S.; Sugiura, Y.; Ueda, K.

    1980-02-19

    The exhaust gas purification device includes an exhaust manifold , a purification cylinder connected with the exhaust manifold through a first honey-comb shaped catalyst, and a second honeycomb shaped catalyst positioned at the rear portion of the purification cylinder. Each catalyst is supported by steel wool rings including coarse and dense portions of steel wool. The purification device further includes a secondary air supplying arrangement.

  19. Infrared thermal annealing device

    NASA Astrophysics Data System (ADS)

    Gladys, M. J.; Clarke, I.; O'Connor, D. J.

    2003-07-01

    A device for annealing samples within an ultrahigh vacuum (UHV) scanning tunneling microscopy system was designed, constructed, and tested. The device is based on illuminating the sample with infrared radiation from outside the UHV chamber with a tungsten projector bulb. The apparatus uses an elliptical mirror to focus the beam through a sapphire viewport for low absorption. Experiments were conducted on clean Pd(100) and annealing temperatures in excess of 1000 K were easily reached.

  20. Design and processing of organic electroluminescent devices

    NASA Astrophysics Data System (ADS)

    Pardo-Guzman, Dino Alejandro

    2000-11-01

    The present dissertation compiles three aspects of my Ph.D. work on OLED device design, fabrication and characterization. The first chapter is a review of the concepts and theories describing the mechanisms of organic electroluminescence. The second chapter makes use of these concepts to articulate some basic principles for the design of efficient and stable OLEDs. The third chapter describes the main characterization and sample preparation techniques used along this dissertation. Chapter IV describes the processing of efficient organic electroluminescent EL devices with ITO/TPD/AIQ3/Mg:Ag structures. The screen printing technique of a hole transport polymeric blend was used in an unusual mode to render thin films in the order of 60-80 nm. EL devices were then fabricated on top of these sp films to provide ~0.9% quantum efficiencies, comparable to spin coating with the same structures. Various polymer:TPD and solvent combinations were studied to find the paste with the best rheological properties. The same technique was also used to deposit a patterned MEH-PPV film. Chapter V describes my research work on the wetting of TPD on ITO substrates. The wetting was monitored by following its surface morphology evolution as a function of temperature. The effect of these surface changes was then correlated to the I-V-L characteristics of devices made with these TPD films. The surface roughness was measured with tapping AFM showed island formation at temperatures as low as 50-60°C. I Also investigated the effect of the purity of materials like AlQ3 on the device EL performance, as described in Chapter VI. In order to improve the purity of these environmentally degradable complexes a new in situ purification technique was developed with excellent enhancement of the EL cell properties. The in situ purification process was then used to purify/deposit organic dyes with improved film formation and EL characteristics.