A graphene based frequency quadrupler

NASA Astrophysics Data System (ADS)

Cheng, Chuantong; Huang, Beiju; Mao, Xurui; Zhang, Zanyun; Zhang, Zan; Geng, Zhaoxin; Xue, Ping; Chen, Hongda

2017-04-01

Benefit from exceptional electrical transport properties, graphene receives worldwide attentions, especially in the domain of high frequency electronics. Due to absence of effective bandgap causing off-state the device, graphene material is extraordinarily suitable for analog circuits rather than digital applications. With this unique ambipolar behavior, graphene can be exploited and utilized to achieve high performance for frequency multipliers. Here, dual-gated graphene field-effect transistors have been firstly used to achieve frequency quadrupling. Two Dirac points in the transfer curves of the designed GFETs can be observed by tuning top-gate voltages, which is essential to generate the fourth harmonic. By applying 200 kHz sinusoid input, arround 50% of the output signal radio frequency power is concentrated at the desired frequency of 800 kHz. Additionally, in suitable operation areas, our devices can work as high performance frequency doublers and frequency triplers. Considered both simple device structure and potential superhigh carrier mobility of graphene material, graphene-based frequency quadruplers may have lots of superiorities in regards to ultrahigh frequency electronic applications in near future. Moreover, versatility of carbon material system is far-reaching for realization of complementary metal-oxide-semiconductor compatible electrically active devices.

Gravitational lensing statistics of amplified supernovae

NASA Technical Reports Server (NTRS)

Linder, Eric V.; Wagoner, Robert V.; Schneider, P.

1988-01-01

Amplification statistics of gravitationally lensed supernovae can provide a valuable probe of the lensing matter in the universe. A general probability distribution for amplification by compact objects is derived which allows calculation of the lensed fraction of supernovae at or greater than an amplification A and at or less than an apparent magnitude. Comparison of the computed fractions with future results from ongoing supernova searches can lead to determination of the mass density of compact dark matter components with masses greater than about 0.001 solar mass, while the time-dependent amplification (and polarization) of the expanding supernovae constrain the individual masses. Type II supernovae are found to give the largest fraction for deep surveys, and the optimum flux-limited search is found to be at approximately 23d magnitude, if evolution of the supernova rate is neglected.

A graphene based frequency quadrupler

PubMed Central

Cheng, Chuantong; Huang, Beiju; Mao, Xurui; Zhang, Zanyun; Zhang, Zan; Geng, Zhaoxin; Xue, Ping; Chen, Hongda

2017-01-01

Benefit from exceptional electrical transport properties, graphene receives worldwide attentions, especially in the domain of high frequency electronics. Due to absence of effective bandgap causing off-state the device, graphene material is extraordinarily suitable for analog circuits rather than digital applications. With this unique ambipolar behavior, graphene can be exploited and utilized to achieve high performance for frequency multipliers. Here, dual-gated graphene field-effect transistors have been firstly used to achieve frequency quadrupling. Two Dirac points in the transfer curves of the designed GFETs can be observed by tuning top-gate voltages, which is essential to generate the fourth harmonic. By applying 200 kHz sinusoid input, arround 50% of the output signal radio frequency power is concentrated at the desired frequency of 800 kHz. Additionally, in suitable operation areas, our devices can work as high performance frequency doublers and frequency triplers. Considered both simple device structure and potential superhigh carrier mobility of graphene material, graphene-based frequency quadruplers may have lots of superiorities in regards to ultrahigh frequency electronic applications in near future. Moreover, versatility of carbon material system is far-reaching for realization of complementary metal-oxide-semiconductor compatible electrically active devices. PMID:28418013

Identification of Microorganisms Isolated From Counterfeit and Unapproved Decorative Contact Lenses.

PubMed

Land, Adrian D; Penno, Katie L; Brzezinski, Jennifer L

2018-03-01

All contact lenses (corrective/noncorrective) are considered Class II or Class III medical devices under the Federal Food, Drug, and Cosmetic Act, which also states that contact lenses can only be obtained with a prescription. The Forensic Chemistry Center of the US Food & Drug Administration has examined over 300 decorative, noncorrective contact lenses obtained without a prescription. Our observations indicate that 60% of the counterfeit lenses and 27% of the unapproved lenses examined were positive for microbial contamination. Twenty-nine different brands of noncorrective contact lenses were examined, and 48% of them had at least one sample positive for microbial contamination. Each microorganism was further identified using DNA sequencing. Contaminated contact lenses are associated with numerous health risks, including ocular infections and conjunctivitis leading to permanent visual impairment or blindness. These results support the contention that acquiring contact lenses without a prescription is a considerable threat to consumer health and safety. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Rabeprazole can overcome the impact of CYP2C19 polymorphism on quadruple therapy.

PubMed

Kuo, Chao-Hung; Wang, Sophie S W; Hsu, Wen-Hung; Kuo, Fu-Chen; Weng, Bi-Chuang; Li, Chia-Jung; Hsu, Ping-I; Chen, Angela; Hung, Wen-Chun; Yang, Yuan-Chieh; Wang, Wen-Ming; Wu, Deng-Chyang

2010-08-01

The prospective study was designed to clarify the impact of CYP2C19 on quadruple therapies and survey the efficacies of rabeprazole-based quadruple therapy for Helicobacter pylori infection after failure of standard triple therapies. From January 2007 to March 2009, 1055 H. pylori-infected patients received standard triple regimens (proton-pump inhibitor (PPI), clarithromycin, and amoxicillin). Helicobacter pylori eradication was achieved in 865 (81.9%) subjects. One hundred ninety eradication-failure patients were enrolled and randomly assigned to receive a 7-day eradication therapy. Ninety-six patients were treated with esomeprazole-based quadruple rescue therapies (EB), while 94 patients were treated with rabeprazole-based quadruple rescue therapies (RB). Follow-up endoscopy was done 16 weeks later to assess the treatment response. Patients' responses, CYP2C19 genotypes, and antibiotics resistances were also examined. Intention-to-treat analysis revealed that RB had better eradication rates than EB (EB: 72.9%; 95% CI: 64.9-80.9% and RB: 78.7%; 95% CI 72.5-84.9%) (p value = .543). Per-protocol results were EB = 75.3%; 95% CI: 70.3-80.3% and RB = 85.1%; 95% CI: 80.6-89.6% (p value = .0401). Both regimens had similar compliance (p value = 0.155) and adverse events (p value = 0.219). We also surveyed those patients without resistance of any antibiotics. RB still showed better outcome than EB. Our data showed that esomeprazole-based regimen and CYP2C19 Hom EM genotype were important predictors for eradication failure. In quadruple therapy, rabeprazole-based regimens had better efficacy than esomeprazole-based regimens. CYP2C19 polymorphism also played an important role in quadruple therapy. It seems advisable to change PPI to rabeprazole in second-line quadruple therapy.

Subaru Weak-Lensing Survey II: Multi-Object Spectroscopy and Cluster Masses

NASA Astrophysics Data System (ADS)

Hamana, Takashi; Miyazaki, Satoshi; Kashikawa, Nobunari; Ellis, Richard S.; Massey, Richard J.; Refregier, Alexandre; Taylor, James E.

2009-08-01

We present the first results of a multi-object spectroscopic campaign to follow up cluster candidates located via weak lensing. Our main goals are to search for spatial concentrations of galaxies that are plausible optical counterparts of the weak-lensing signals, and to determine the cluster redshifts from those of member galaxies. Around each of 36 targeted cluster candidates, we obtained 15-32 galaxy redshifts. For 28 of these targets, we confirmed a secure cluster identification, with more than five spectroscopic galaxies within a velocity of ±3000km s-1. This includes three cases where two clusters at different redshifts are projected along the same line-of-sight. In 6 of the 8 unconfirmed targets, we found multiple small galaxy concentrations at different redshifts, each containing at least three spectroscopic galaxies. The weak-lensing signal around those systems was thus probably created by the projection of groups or small clusters along the same line-of-sight. In both of the remaining two targets, a single small galaxy concentration was found. In some candidate super-cluster systems, we found additional evidence of filaments connecting the main density peak to an additional nearby structure. For a subsample of our most cleanly measured clusters, we investigated the statistical relation between their weak-lensing mass (MNFW, σSIS) and the velocity dispersion of their member galaxies (σv), comparing our sample with optically and X-ray selected samples from the literature. Our lensing-selected clusters are consistent with σv = σSIS, with a similar scatter to that of optically and X-ray selected clusters. We also derived an empirical relation between the cluster mass and the galaxy velocity dispersion, M200E(z) = 11.0 × 1014 × (σv/1000km s-1)3.0 h-1 Modot, which is in reasonable agreement with predictions of N-body simulations in the Λ CDM cosmology.

SKA weak lensing- II. Simulated performance and survey design considerations

NASA Astrophysics Data System (ADS)

Bonaldi, Anna; Harrison, Ian; Camera, Stefano; Brown, Michael L.

2016-12-01

We construct a pipeline for simulating weak lensing cosmology surveys with the Square Kilometre Array (SKA), taking as inputs telescope sensitivity curves; correlated source flux, size and redshift distributions; a simple ionospheric model; source redshift and ellipticity measurement errors. We then use this simulation pipeline to optimize a 2-yr weak lensing survey performed with the first deployment of the SKA (SKA1). Our assessments are based on the total signal to noise of the recovered shear power spectra, a metric that we find to correlate very well with a standard dark energy figure of merit. We first consider the choice of frequency band, trading off increases in number counts at lower frequencies against poorer resolution; our analysis strongly prefers the higher frequency Band 2 (950-1760 MHz) channel of the SKA-MID telescope to the lower frequency Band 1 (350-1050 MHz). Best results would be obtained by allowing the centre of Band 2 to shift towards lower frequency, around 1.1 GHz. We then move on to consider survey size, finding that an area of 5000 deg2 is optimal for most SKA1 instrumental configurations. Finally, we forecast the performance of a weak lensing survey with the second deployment of the SKA. The increased survey size (3π steradian) and sensitivity improves both the signal to noise and the dark energy metrics by two orders of magnitude.

On the Lack of Correlation Between Mg II 2796, 2803 Angstrom and Lyman alpha Emission in Lensed Star-Forming Galaxies

NASA Technical Reports Server (NTRS)

Rigby, Jane Rebecca; Bayliss, M. B.; Gladders, M. D.; Sharon, K.; Wuyts, E.; Dahle, H.

2014-01-01

We examine the Mg II 2796, 2803 Angstrom, Lyman alpha, and nebular line emission in five bright star-forming galaxies at 1.66 less than z less than 1.91 that have been gravitationally lensed by foreground galaxy clusters. All five galaxies show prominent Mg II emission and absorption in a P Cygni profile. We find no correlation between the equivalent widths of Mg II and Lyman alpha emission. The Mg II emission has a broader range of velocities than do the nebular emission line profiles; the Mg II emission is redshifted with respect to systemic by 100 to 200 km s(exp-1). When present, Lyman alpha is even more redshifted. The reddest components of Mg II and Lyman alpha emission have tails to 500-600 km s(exp-1), implying a strong outflow. The lack of correlation in the Mg II and Lyman alpha equivalent widths, the differing velocity profiles, and the high ratios of Mg II to nebular line fluxes together suggest that the bulk of Mg II emission does not ultimately arise as nebular line emission, but may instead be reprocessed stellar continuum emission.

LENSED: a code for the forward reconstruction of lenses and sources from strong lensing observations

NASA Astrophysics Data System (ADS)

Tessore, Nicolas; Bellagamba, Fabio; Metcalf, R. Benton

2016-12-01

Robust modelling of strong lensing systems is fundamental to exploit the information they contain about the distribution of matter in galaxies and clusters. In this work, we present LENSED, a new code which performs forward parametric modelling of strong lenses. LENSED takes advantage of a massively parallel ray-tracing kernel to perform the necessary calculations on a modern graphics processing unit (GPU). This makes the precise rendering of the background lensed sources much faster, and allows the simultaneous optimization of tens of parameters for the selected model. With a single run, the code is able to obtain the full posterior probability distribution for the lens light, the mass distribution and the background source at the same time. LENSED is first tested on mock images which reproduce realistic space-based observations of lensing systems. In this way, we show that it is able to recover unbiased estimates of the lens parameters, even when the sources do not follow exactly the assumed model. Then, we apply it to a subsample of the Sloan Lens ACS Survey lenses, in order to demonstrate its use on real data. The results generally agree with the literature, and highlight the flexibility and robustness of the algorithm.

The MICE Grand Challenge light-cone simulation - III. Galaxy lensing mocks from all-sky lensing maps

NASA Astrophysics Data System (ADS)

Fosalba, P.; Gaztañaga, E.; Castander, F. J.; Crocce, M.

2015-02-01

In Paper I of this series, we presented a new N-body light-cone simulation from the MICE Collaboration, the MICE Grand Challenge (MICE-GC), containing about 70 billion dark-matter particles in a (3 h-1 Gpc)3 comoving volume, from which we built halo and galaxy catalogues using a Halo Occupation Distribution and Halo Abundance Matching technique, as presented in the companion Paper II. Given its large volume and fine mass resolution, the MICE-GC simulation also allows an accurate modelling of the lensing observables from upcoming wide and deep galaxy surveys. In the last paper of this series (Paper III), we describe the construction of all-sky lensing maps, following the `Onion Universe' approach, and discuss their properties in the light-cone up to z = 1.4 with sub-arcminute spatial resolution. By comparing the convergence power spectrum in the MICE-GC to lower mass-resolution (i.e. particle mass ˜1011 h-1 M⊙) simulations, we find that resolution effects are at the 5 per cent level for multipoles ℓ ˜ 103 and 20 per cent for ℓ ˜ 104. Resolution effects have a much lower impact on our simulation, as shown by comparing the MICE-GC to recent numerical fits by Takahashi. We use the all-sky lensing maps to model galaxy lensing properties, such as the convergence, shear, and lensed magnitudes and positions, and validate them thoroughly using galaxy shear auto and cross-correlations in harmonic and configuration space. Our results show that the galaxy lensing mocks here presented can be used to accurately model lensing observables down to arcminute scales. Accompanying this series of papers, we make a first public data release of the MICE-GC galaxy mock, the MICECAT v1.0, through a dedicated web-portal for the MICE simulations, http://cosmohub.pic.es, to help developing and exploiting the new generation of astronomical surveys.

Nonbismuth concomitant quadruple therapy for Helicobacter pylori eradication in Chinese regions: A meta-analysis of randomized controlled trials

PubMed Central

Lin, Lien-Chieh; Hsu, Tzu-Herng; Huang, Kuang-Wei; Tam, Ka-Wai

2016-01-01

AIM: To evaluate the applicability of nonbismuth concomitant quadruple therapy for Helicobacter pylori (H. pylori) eradication in Chinese regions. METHODS: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the efficacy of nonbismuth concomitant quadruple therapy between sequential therapy or triple therapy for H. pylori eradication in Chinese regions. The defined Chinese regions include China, Hong Kong, Taiwan, and Singapore. The primary outcome was the H. pylori eradication rate; the secondary outcome was the compliance with therapy. The PubMed, Embase, Scopus, and Cochrane databases were searched for studies published in the period up to March 2016 with no language restriction. RESULTS: We reviewed six randomized controlled trials and 1616 patients. In 3 trials comparing concomitant quadruple therapy with triple therapy, the H. pylori eradication rate was significantly higher for 7-d nonbismuth concomitant quadruple therapy than for 7-d triple therapy (91.2% vs 77.9%, risk ratio = 1.17, 95%CI: 1.09-1.25). In 3 trials comparing quadruple therapy with sequential therapy, the eradication rate was not significant between groups (86.9% vs 86.0%). However, higher compliance was achieved with concomitant therapy than with sequential therapy. CONCLUSION: The H. pylori eradication rate was higher for nonbismuth concomitant quadruple therapy than for triple therapy. Moreover, higher compliance was achieved with nonbismuth concomitant quadruple therapy than with sequential therapy. Thus, nonbismuth concomitant quadruple therapy should be the first-line treatment in Chinese regions. PMID:27340362

HERSCHEL EXTREME LENSING LINE OBSERVATIONS: [C ii] VARIATIONS IN GALAXIES AT REDSHIFTS z = 1–3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malhotra, Sangeeta; Rhoads, James E.; Yang, Huan

We observed the [C ii] line in 15 lensed galaxies at redshifts 1 < z < 3 using HIFI on the Herschel Space Observatory and detected 14/15 galaxies at 3 σ or better. High magnifications enable even modestly luminous galaxies to be detected in [C ii] with Herschel . The [C ii] luminosity in this sample ranges from 8 × 10{sup 7} L {sub ⊙} to 3.7 × 10{sup 9} L {sub ⊙} (after correcting for magnification), confirming that [C ii] is a strong tracer of the ISM at high redshifts. The ratio of the [C ii] line to themore » total far-infrared (FIR) luminosity serves as a measure of the ratio of gas to dust cooling and thus the efficiency of the grain photoelectric heating process. It varies between 3.3% and 0.09%. We compare the [C ii]/FIR ratio to that of galaxies at z = 0 and at high redshifts and find that they follow similar trends. The [C ii]/FIR ratio is lower for galaxies with higher dust temperatures. This is best explained if increased UV intensity leads to higher FIR luminosity and dust temperatures, but gas heating does not rise due to lower photoelectric heating efficiency. The [C ii]/FIR ratio shows weaker correlation with FIR luminosity. At low redshifts highly luminous galaxies tend to have warm dust, so the effects of dust temperature and luminosity are degenerate. Luminous galaxies at high redshifts show a range of dust temperatures, showing that [C ii]/FIR correlates most strongly with dust temperature. The [C ii] to mid-IR ratio for the HELLO sample is similar to the values seen for low-redshift galaxies, indicating that small grains and PAHs dominate the heating in the neutral ISM, although some of the high [CII]/FIR ratios may be due to turbulent heating.« less

The Optical Gravitational Lensing Experiment: catalogue of stellar proper motions in the OGLE-II Galactic bulge fields

NASA Astrophysics Data System (ADS)

Sumi, T.; Wu, X.; Udalski, A.; Szymański, M.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Woźniak, P.; Żebruń, K.; Szewczyk, O.; Wyrzykowski, Ł.

2004-03-01

We present a proper-motion (μ) catalogue of 5 080 236 stars in 49 Optical Gravitational Lensing Experiment II (OGLE-II) Galactic bulge (GB) fields, covering a range of -11° < l < 11° and -6° < b < 3°, the total area close to 11 deg2. The proper-motion measurements are based on 138-555 I-band images taken during four observing seasons: 1997-2000. The catalogue stars are in the magnitude range 11 < I < 18 mag. In particular, the catalogue includes red clump giants and red giants in the GB, and main-sequence stars in the Galactic disc. The proper motions up to μ= 500 mas yr-1 were measured with a mean accuracy of 0.8-3.5 mas yr-1, depending on the brightness of a star. This catalogue may be useful for studying the kinematics of stars in the GB and the Galactic disc.

Golden gravitational lensing systems from the Sloan Lens ACS Survey - II. SDSS J1430+4105: a precise inner total mass profile from lensing alone

NASA Astrophysics Data System (ADS)

Eichner, Thomas; Seitz, Stella; Bauer, Anne

2012-12-01

We study the Sloan Lens ACS (SLACS) survey strong-lensing system SDSS J1430+4105 at zl = 0.285. The lensed source (zs = 0.575) of this system has a complex morphology with several subcomponents. Its subcomponents span a radial range from 4 to 10 kpc in the plane of the lens. Therefore, we can constrain the slope of the total projected mass profile around the Einstein radius from lensing alone. We measure a density profile that is slightly but not significantly shallower than isothermal at the Einstein radius. We decompose the mass of the lensing galaxy into a de Vaucouleurs component to trace the stars and an additional dark component. The spread of multiple-image components over a large radial range also allows us to determine the amplitude of the de Vaucouleurs and dark matter components separately. We get a mass-to-light ratio of M de Vauc LB ≈ (5.5±1.5) M⊙L⊙,B and a dark matter fraction within the Einstein radius of ≈20 to 40 per cent. Modelling the star formation history assuming composite stellar populations at solar metallicity to the galaxy's photometry yields a mass-to-light ratio of M, salp LB ≈ 4.0-1.3+0.6 M⊙L⊙,B and M, chab LB ≈ 2.3-0.8+0.3 M⊙L⊙,B for Salpeter and Chabrier initial mass functions, respectively. Hence, the mass-to-light ratio derived from lensing is more Salpeter like, in agreement with results for massive Coma galaxies and other nearby massive early-type galaxies. We examine the consequences of the galaxy group in which the lensing galaxy is embedded, showing that it has little influence on the mass-to-light ratio obtained for the de Vaucouleurs component of the lensing galaxy. Finally, we decompose the projected, azimuthally averaged 2D density distribution of the de

Types of Contact Lenses

MedlinePlus

... Consumer Devices Consumer Products Contact Lenses Types of Contact Lenses Share Tweet Linkedin Pin it More sharing ... Orthokeratology (Ortho-K) Decorative (Plano) Contact Lenses Soft Contact Lenses Soft contact lenses are made of soft, ...

[Effect of furazolidone quadruple regimen plus dental plaque removal procedures as rescue treatment of refractory Helicobacter pylori infection].

PubMed

Gao, Wen; Hu, Fu-lian; Wang, Xiao-min

2011-03-29

To observe the effect of furazolidone quadruple regimen plus dental plaque removal procedures as rescue treatment of refractory H. pylori infection. A total of 104 patients with H. pylori positive [(13)C-urea breath test (UBT) or rapid urease test positive] failing in previous treatment two or more were enrolled and divided into 2 groups. One group (n = 64) were given quadruple regimen [proton pump inhibitor (PPI) + bismuth + amoxicillin + furazolidone, 10 days] treatment and dental plaque removal treatment. And the others (n = 40) received only quadruple regimen treatment. The status of H. pylori was detected by (13)C-UBT at 4 weeks post-therapy and the eradication rates of two groups were compared. The eradication rate of quadruple regimen + dental treatment group was 85.9% (55/64) while that of the other group 72.5% (29/40) (P = 0.091). The PPI + bismuth quadruple regimen plus dental plaque removal procedures as rescue treatment may boost the eradication rate of refractory H. pylori infection patients. And the furazolidone quadruple therapy can be chosen for the treatment of refractory H. pylori infection. Oral H. pylori infection may play a role in the failure of H. pylori infection treatment.

[Influence of Saccharomyces boulardii Sachets combined with bismuth quadruple therapy for initial Helicobacter pylori eradication].

PubMed

Zhu, X Y; Du, J; Wu, J; Zhao, L W; Meng, X; Liu, G F

2017-08-08

Objective: To evaluate the efficacy and safety of Saccharomyces boulardii Sachets combined with bismuth quadruple therapy for initial Helicobacter pylori ( H . pylori ) eradication. Methods: From March 2014 to March 2015, 240 participants from the third hospital of Hebei medical university with H . pylori infection were recruited and randomized into three groups: Quadruple therapy group received bismuth potassium citrate 220 mg bid + Rabeprazole 10 mg bid + amoxicillin 1 000 mg bid+ furazolidone 100 mg bid for 10 days. Short-term group and long-term group received the same quadruple therapy for 10 days as above, as well as Saccharomyces boulardii Sachets 500 mg bid for 14 days and 28 days, respectively. H . pylori eradication was confirmed by (13)C/(14)C-UBT at least 4 weeks after completion of therapy. And side effects were investigated during the therapy. Results: The H . pylori eradication rates in quadruple therapy, short-term and long-term group were 80%, 87.5% and 87.5% by ITT analysis ( P =0.321) and 92.8%, 94.6% and 95.9% by PP analysis ( P =0.717), respectively. The overall side effect rate and occurrence of diarrhea and abdominal distension were significantly lower in short-term or long-term group as compared with quadruple therapy group( P =0.007, 0.003, 0.004), but there was no significant difference between the two probiotics groups. Conclusions: Both short and long-term Saccharomyces boulardii Sachets reduced the overall side effect rate and occurrence of diarrhea or abdominal distension when combined with bismuth quadruple therapy for initial H . pylori eradication and no difference was observed in efficacy or safety between the two groups.

The Optical Gravitational Lensing Experiment Catalog of stellar proper motions in the OGLE-II Galactic bulge fields

NASA Astrophysics Data System (ADS)

Sumi, T.; Wu, X.; Udalski, A.; Szymański, M.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Woźniak, P.; Zebruń, K.; Szewczyk, O.; Wyrzykowski, L.

2003-12-01

We present proper motion (μ ) catalogue of 5,078,188 stars in 49 Optical Gravitational Lensing Experiment II (OGLE-II) Galactic bulge fields, with the total area close to 11 square degrees. The proper motion measurements are based on 138 - 555 I-band images taken during four observing seasons: 1997-2000. The catalogue stars are in the magnitude range 11 < I < 18 mag. In particular, the catalogue includes Red Clump Giants (RCGs) and Red Giants in the Galactic Bulge, and main sequence stars in the Galactic disc. The proper motions up to μ = 500 mas yr -1 were measured with the mean accuracy of 0.8 ˜ 3.5 mas yr-1, depending on the brightness of a star. This catalogue may be useful for studying the kinematic of stars in the Galactic Bulge and the Galactic disk with Extinction maps in these fields which are construncted by using two-band photometry of RCGs.

Filterless low-phase-noise frequency-quadrupled microwave generation based on a multimode optoelectronic oscillator

NASA Astrophysics Data System (ADS)

Teng, Yichao; Zhang, Pin; Zhang, Baofu; Chen, Yiwang

2018-02-01

A scheme to realize low-phase-noise frequency-quadrupled microwave generation without any filter is demonstrated. In this scheme, a multimode optoelectronic oscillator is mainly contributed by dual-parallel Mach-Zehnder modulators, fiber, photodetector, and microwave amplifier. The local source signal is modulated by a child MZM (MZMa), which is worked at maximum transmission point. Through properly adjusting the bias voltages of the other child MZM (MZMb) and the parent MZM (MZMc), optical carrier is effectively suppressed and second sidebands are retained, then the survived optical signal is fed back to the photodetector and MZMb to form an optoelectronic hybrid resonator and realize frequency-quadrupled signal generation. Due to the high Q-factor and mode selection effect of the optoelectronic hybrid resonator, compared with the source signal, the generated frequency-quadrupled signal has a lower phase noise. The approach has verified by experiments, and 18, 22, and 26 GHz frequency-quadrupled signal are generated by 4.5, 5.5, and 6.5 GHz local source signals. Compared with 4.5 GHz source signal, the phase noise of generated 18 GHz signal at 10 kHz frequency offset has 26.5 dB reduction.

EPIC 219217635: A Doubly Eclipsing Quadruple System Containing an Evolved Binary

NASA Astrophysics Data System (ADS)

Borkovits, T.; Albrecht, S.; Rappaport, S.; Nelson, L.; Vanderburg, A.; Gary, B. L.; Tan, T. G.; Justesen, A. B.; Kristiansen, M. H.; Jacobs, T. L.; LaCourse, D.; Ngo, H.; Wallack, N.; Ruane, G.; Mawet, D.; Howell, S. B.; Tronsgaard, R.

2018-05-01

We have discovered a doubly eclipsing, bound, quadruple star system in the field of K2 Campaign 7. EPIC 219217635 is a stellar image with Kp = 12.7 that contains an eclipsing binary (`EB') with PA = 3.59470 d and a second EB with PB = 0.61825 d. We have obtained followup radial-velocity (`RV') spectroscopy observations, adaptive optics imaging, as well as ground-based photometric observations. From our analysis of all the observations, we derive good estimates for a number of the system parameters. We conclude that (1) both binaries are bound in a quadruple star system; (2) a linear trend to the RV curve of binary A is found over a 2-year interval, corresponding to an acceleration, \\dot{γ }= 0.0024 ± 0.0007 cm s-2; (3) small irregular variations are seen in the eclipse-timing variations (`ETVs') detected over the same interval; (4) the orbital separation of the quadruple system is probably in the range of 8-25 AU; and (5) the orbital planes of the two binaries must be inclined with respect to each other by at least 25°. In addition, we find that binary B is evolved, and the cooler and currently less massive star has transferred much of its envelope to the currently more massive star. We have also demonstrated that the system is sufficiently bright that the eclipses can be followed using small ground-based telescopes, and that this system may be profitably studied over the next decade when the outer orbit of the quadruple is expected to manifest itself in the ETV and/or RV curves.

The M31 Pixel Lensing PLAN Campaign: MACHO Lensing and Self-lensing Signals

NASA Astrophysics Data System (ADS)

Calchi Novati, S.; Bozza, V.; Bruni, I.; Dall'Ora, M.; De Paolis, F.; Dominik, M.; Gualandi, R.; Ingrosso, G.; Jetzer, Ph.; Mancini, L.; Nucita, A.; Safonova, M.; Scarpetta, G.; Sereno, M.; Strafella, F.; Subramaniam, A.; Gould, A.; PLAN Collaboration

2014-03-01

We present the final analysis of the observational campaign carried out by the PLAN (Pixel Lensing Andromeda) collaboration to detect a dark matter signal in form of MACHOs through the microlensing effect. The campaign consists of about 1 month/year observations carried out over 4 years (2007-2010) at the 1.5 m Cassini telescope in Loiano (Astronomical Observatory of BOLOGNA, OAB) plus 10 days of data taken in 2010 at the 2 m Himalayan Chandra Telescope monitoring the central part of M31 (two fields of about 13' × 12.'6). We establish a fully automated pipeline for the search and the characterization of microlensing flux variations. As a result, we detect three microlensing candidates. We evaluate the expected signal through a full Monte Carlo simulation of the experiment completed by an analysis of the detection efficiency of our pipeline. We consider both "self lensing" and "MACHO lensing" lens populations, given by M31 stars and dark matter halo MACHOs, in M31 and the Milky Way, respectively. The total number of events is consistent with the expected self-lensing rate. Specifically, we evaluate an expected signal of about two self-lensing events. As for MACHO lensing, for full 0.5(10-2) M ⊙ MACHO halos, our prediction is for about four (seven) events. The comparatively small number of expected MACHO versus self-lensing events, together with the small number statistics at our disposal, do not enable us to put strong constraints on that population. Rather, the hypothesis, suggested by a previous analysis, on the MACHO nature of OAB-07-N2, one of the microlensing candidates, translates into a sizeable lower limit for the halo mass fraction in form of the would-be MACHO population, f, of about 15% for 0.5 M ⊙ MACHOs.

Descriptive analysis of the type and design of contact lenses fitted according to keratoconus severity and morphology.

PubMed

Lunardi, Letícia Helena; Arroyo, Danielle; Andrade Sobrinho, Marcelo Vicente de; Lipener, César; Rosa, Juliana Maria da Silva

2016-04-01

Keratoconus is characterized by bilateral asymmetrical corneal ectasia that leads to inferior stromal thinning and corneal protrusion. There is currently a lack of consensus regarding the most efficacious method for fitting contact lenses in patients with keratoconus, given the various topographical patterns and evolution grades observed in affected populations. The purpose of the present study was to evaluate the association between keratoconus evolution grade and topography pattern and the type and design of fitted contact lens. We performed a retrospective analysis of contact lenses fitted in a total of 185 patients with keratoconus (325 eyes). Keratoconus was classified as either grade I, II, III, or IV based on keratometry and cone morphology (nipple, oval, globus, or indeterminate) results. A total of 325 eyes were evaluated in the present study. Of the 62 eyes classified as grade I, 66.1% were fitted with monocurve contact lenses. Of the 162 eyes classified as grade I and II, 51%, 30%, and 19% were fitted with adapted monocurve rigid gas-permeable contact lenses (RGPCL), bicurve lenses, and others lens types, respectively. Bicurve lenses were fitted in 52.1% and 62.2% of eyes classified as grade III and IV, respectively. Of the eyes classified as grade III and IV, monocurve and bicurve RGPCL were fitted in 26% and 55%, respectively. In eyes with oval keratoconus, 45%, 35%, and 20% were fitted with monocurve lenses, bicurve lenses, and other lens types, respectively. In eyes with round cones (nipple morphology), 55%, 30%, and 15% were fitted with bicurve lenses, monocurve lenses, and other lens types, respectively. Monocurve RGPCL were most frequently fitted in patients with mild to moderate keratoconus and oval cones morphology, while bicurve lenses were more frequently fitted in patients with severe and advanced keratoconus. This was probably because bicurve lenses are more appropriate for round cones due to increased corneal asphericity.

Rest-Frame Optical Spectra of Three Strongly Lensed Galaxies at z ~ 2

NASA Astrophysics Data System (ADS)

Hainline, Kevin N.; Shapley, Alice E.; Kornei, Katherine A.; Pettini, Max; Buckley-Geer, Elizabeth; Allam, Sahar S.; Tucker, Douglas L.

2009-08-01

We present Keck II NIRSPEC rest-frame optical spectra for three recently discovered lensed galaxies: the Cosmic Horseshoe (z = 2.38), the Clone (z = 2.00), and SDSS J090122.37+181432.3 (z = 2.26). The boost in signal-to-noise ratio (S/N) from gravitational lensing provides an unusually detailed view of the physical conditions in these objects. A full complement of high S/N rest-frame optical emission lines is measured, spanning from rest frame 3600 to 6800 Å, including robust detections of fainter lines such as Hγ, [S II]λ6717,6732, and in one instance [Ne III]λ3869. SDSS J090122.37+181432.3 shows evidence for active galactic nucleus activity, and therefore we focus our analysis on star-forming regions in the Cosmic Horseshoe and the Clone. For these two objects, we estimate a wide range of physical properties. Current lensing models for the Cosmic Horseshoe and the Clone allow us to correct the measured Hα luminosity and calculated star formation rate. Metallicities have been estimated with a variety of indicators, which span a range of values of 12+ log(O/H) = 8.3-8.8, between ~0.4 and ~1.5 of the solar oxygen abundance. Dynamical masses were computed from the Hα velocity dispersions and measured half-light radii of the reconstructed sources. A comparison of the Balmer lines enabled measurement of dust reddening coefficients. Variations in the line ratios between the different lensed images are also observed, indicating that the spectra are probing different regions of the lensed galaxies. In all respects, the lensed objects appear fairly typical of ultraviolet-selected star-forming galaxies at z ~ 2. The Clone occupies a position on the emission-line diagnostic diagram of [O III]/Hβ versus [N II]/Hα that is offset from the locations of z ~ 0 galaxies. Our new NIRSPEC measurements may provide quantitative insights into why high-redshift objects display such properties. From the [S II] line ratio, high electron densities (~1000 cm-3) are inferred compared

Phakic Intraocular Lenses

MedlinePlus

... Implants and Prosthetics Phakic Intraocular Lenses Phakic Intraocular Lenses Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print Phakic intraocular lenses are new devices used to correct nearsightedness. These ...

Galaxy cluster lensing masses in modified lensing potentials

DOE PAGES

Barreira, Alexandre; Li, Baojiu; Jennings, Elise; ...

2015-10-28

In this study, we determine the concentration–mass relation of 19 X-ray selected galaxy clusters from the Cluster Lensing and Supernova Survey with Hubble survey in theories of gravity that directly modify the lensing potential. We model the clusters as Navarro–Frenk–White haloes and fit their lensing signal, in the Cubic Galileon and Nonlocal gravity models, to the lensing convergence profiles of the clusters. We discuss a number of important issues that need to be taken into account, associated with the use of non-parametric and parametric lensing methods, as well as assumptions about the background cosmology. Our results show that the concentrationmore » and mass estimates in the modified gravity models are, within the error bars, the same as in Λ cold dark matter. This result demonstrates that, for the Nonlocal model, the modifications to gravity are too weak at the cluster redshifts, and for the Galileon model, the screening mechanism is very efficient inside the cluster radius. However, at distances ~ [2–20] Mpc/h from the cluster centre, we find that the surrounding force profiles are enhanced by ~ 20–40% in the Cubic Galileon model. This has an impact on dynamical mass estimates, which means that tests of gravity based on comparisons between lensing and dynamical masses can also be applied to the Cubic Galileon model.« less

Quadruple therapy for eradication of Helicobacter pylori

PubMed Central

Ma, Hai-Jun; Wang, Jin-Liang

2013-01-01

AIM: To investigate quadruple therapy with rabeprazole, amoxicillin, levofloxacin and furazolidone for the eradication of Helicobacter pylori (H. pylori) infection. METHODS: A total of 147 patients were divided into the experimental treatment group (n = 78) and the standard triple treatment group (n = 69). The experimental treatment group received rabeprazole 20 mg, amoxicillin 1.0 g, levofloxacin 0.2 g and furazolidone 0.1 g, twice daily. The standard triple treatment group received omeprazole 20 mg, amoxicillin 1.0 g and clarithromycin 0.5 g, twice daily. RESULTS: One month after treatment, the 13C urea breath test was carried out to detect H. pylori. The eradication rate using per-protocol analysis was 94.3% in the experimental treatment group and 73% in the standard triple treatment group (P < 0.05), and using intention to test analysis, these figures were 86% and 67% in the two groups, respectively. Side effects were observed in 34 patients, and included mild dizziness, nausea, diarrhea and increased bowel movement. Eleven of the 34 patients needed no treatment for their side effects. CONCLUSION: Rabeprazole, amoxicillin, levofloxacin and furazolidone quadruple therapy is a safe method for the eradication of H. pylori with high efficacy and good tolerability. PMID:23429422

Subfactors of Index Less Than 5, Part 3: Quadruple Points

NASA Astrophysics Data System (ADS)

Izumi, Masaki; Jones, Vaughan F. R.; Morrison, Scott; Snyder, Noah

2012-12-01

One major obstacle in extending the classification of small index subfactors beyond {3 +sqrt{3}} is the appearance of infinite families of candidate principal graphs with 4-valent vertices (in particular, the "weeds" {{Q}} and {{Q}'} from Part 1 (Morrison and Snyder in Commun. Math. Phys., doi: 10.1007/s00220-012-1426-y, 2012). Thus instead of using triple point obstructions to eliminate candidate graphs, we need to develop new quadruple point obstructions. In this paper we prove two quadruple point obstructions. The first uses quadratic tangles techniques and eliminates the weed {{Q}'} immediately. The second uses connections, and when combined with an additional number theoretic argument it eliminates both weeds {{Q}} and {{Q}'} . Finally, we prove the uniqueness (up to taking duals) of the 3311 Goodman-de la Harpe-Jones subfactor using a combination of planar algebra techniques and connections.

A novel procedure for the extraction of protein deposits from soft hydrophilic contact lenses for analysis.

PubMed

Keith, D; Hong, B; Christensen, M

1997-05-01

A quick, simple, and efficient extraction technique was developed for the removal of protein from soft hydrophilic contact lenses. An extraction solvent consisting of a 50:50 mix of 0.2% trifluoroacetic acid and acetonitrile was used to remove protein from in vitro laboratory-deposited and human-worn contact lenses. The protein removed was analyzed using HPLC, bicinchoninic acid (BCA) analysis, and SDS-PAGE gel electreophoresis. Extraction efficiency for lysozyme from laboratory-deposited Group IV lenses was determined to be approximately 100%. Group IV human-worn contact lenses were extracted and analyzed for lysozyme by HPLC and total protein by bicinchoninic acid (BCA) analysis. Groups I, II, III, and IV contact lenses deposited with an artificial tear protein solution and human-worn lenses were extracted and analyzed by SDS-PAGE gel electreophoresis and micro-BCA. The ACN/TFA procedure offers a simple, quick, and efficient extraction technique for removal of protein from contact lenses for subsequent analysis.

Dynamic viscoelasticity measurement under alternative torque using electromagnetically spinning method with quadruple electromagnets.

PubMed

Matsuura, Yusuke; Hirano, Taichi; Sakai, Keiji

2017-07-01

In this study, we developed a novel type of rheological measurement system. Here, a spherical probe is driven to rotate periodically by applying torques using quadruple electromagnets in a noncontact manner. Moreover, this system is an enhancement of our electromagnetically spinning (EMS) viscometer, which is widely used for measuring rheological flow curves in various industrial fields. The quadruple EMS method provides the frequency spectrum of viscoelasticity, in addition to shear viscosity, in a steady flow by switching the operation modes of the driving torque. We show the results obtained for Newtonian fluids and viscoelastic materials and demonstrate the validity of the system.

Arcs from gravitational lensing

NASA Technical Reports Server (NTRS)

Grossman, Scott A.; Narayan, Ramesh

1988-01-01

The proposal made by Paczynski (1987) that the arcs of blue light found recently in two cluster cores are gravitationally lensed elongated images of background galaxies is investigated. It is shown that lenses that are circularly symmetric in projection produce pairs of arcs, in conflict with the observations. However, more realistic asymmetric lenses produce single arcs, which can become as elongated as the observed ones whenever the background galaxy is located on or close to a cusp caustic. Detailed computer simulations of lensing by clusters using a reasonable model of the mass distribution are presented. Elongated and curved lensed images longer than 10 arcsec occur in 12 percent of the simulated clusters. It is concluded that the lensing hypothesis must be taken seriously.

Prospective study of the feasibility and effectiveness of a second-trimester quadruple test for Down syndrome in Thailand.

PubMed

Kaewsuksai, Peeranan; Jitsurong, Siroj

2017-11-01

To evaluate the feasibility and effectiveness of a quadruple test for Down syndrome in the second trimester of pregnancy in clinical settings in Thailand. From October 2015 to September 2016, a prospective study was undertaken in 19 hospitals in Songkhla province, Thailand. Women with a singleton pregnancy of 14-18 weeks were enrolled and underwent the quadruple test. The risk cutoff value was set at 1:250. All women with a positive test (risk ≥1:250) were offered amniocentesis. Women were followed up until delivery. Among 2375 women, 206 (8.7%) had a positive quadruple test; 98 (47.6%) of these women voluntarily underwent amniocentesis. Overall, seven pregnancies were complicated with chromosomal abnormalities (2.9 cases in 1000), including four cases of Down syndrome (1.7 in 1000) and three of other abnormalities. The detection, false-positive, and accuracy rates of the quadruple test for Down syndrome were 75.0%, 8.6%, and 91.4%, respectively. The quadruple test was found to be a feasible and efficient method for screening for Down syndrome in the second trimester of pregnancy in a Thai clinical setting. The test should be performed for pregnant women before an invasive test for Down syndrome. © 2017 International Federation of Gynecology and Obstetrics.

COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. III. Redshift of the lensing galaxy in eight gravitationally lensed quasars

NASA Astrophysics Data System (ADS)

Eigenbrod, A.; Courbin, F.; Meylan, G.; Vuissoz, C.; Magain, P.

2006-06-01

Aims.We measure the redshift of the lensing galaxy in eight gravitationally lensed quasars in view of determining the Hubble parameter H0 from the time delay method. Methods.Deep VLT/FORS1 spectra of lensed quasars are spatially deconvolved in order to separate the spectrum of the lensing galaxies from the glare of the much brighter quasar images. A new observing strategy is devised. It involves observations in Multi-Object-Spectroscopy (MOS) which allows the simultaneous observation of the target and of several PSF and flux calibration stars. The advantage of this method over traditional long-slit observations is a much more reliable extraction and flux calibration of the spectra. Results.For the first time we measure the redshift of the lensing galaxy in three multiply-imaged quasars: SDSS J1138+0314 (z_lens = 0.445), SDSS J1226-0006 (z_lens = 0.517), SDSS J1335+0118 (z_lens = 0.440), and we give a tentative estimate of the redshift of the lensing galaxy in Q 1355-2257 (z_lens = 0.701). We confirm four previously measured redshifts: HE 0047-1756 (z_lens = 0.407), HE 0230-2130 (z_lens = 0.523), HE 0435-1223 (z_lens = 0.454) and WFI J2033-4723 (z_lens = 0.661). In addition, we determine the redshift of the second lensing galaxy in HE 0230-2130 (z_lens = 0.526). The spectra of all lens galaxies are typical for early-type galaxies, except for the second lensing galaxy in HE 0230-2130 which displays prominent [OII] emission.

First measurement of the cross-correlation of CMB lensing and galaxy lensing

DOE PAGES

Hand, Nick; Leauthaud, Alexie; Das, Sudeep; ...

2015-03-02

Here, we measure the cross-correlation of cosmic microwave background (CMB) lensing convergence maps derived from Atacama Cosmology Telescope data with galaxy lensing convergence maps as measured by the Canada-France-Hawaii Telescope Stripe 82 Survey. The CMB-galaxy lensing cross power spectrum is measured for the first time with a significance of 4.2 sigma, which corresponds to a 12% constraint on the amplitude of density fluctuations at redshifts ~0.9. With upcoming improved lensing data, this novel type of measurement will become a powerful cosmological probe, providing a precise measurement of the mass distribution at intermediate redshifts and serving as a calibrator for systematicmore » biases in weak lensing measurements.« less

Micro-optofluidic Lenses: A review

PubMed Central

Nguyen, Nam-Trung

2010-01-01

This review presents a systematic perspective on the development of micro-optofluidic lenses. The progress on the development of micro-optofluidic lenses are illustrated by example from recent literature. The advantage of micro-optofluidic lenses over solid lens systems is their tunability without the use of large actuators such as servo motors. Depending on the relative orientation of light path and the substrate surface, micro-optofluidic lenses can be categorized as in-plane or out-of-plane lenses. However, this review will focus on the tunability of the lenses and categorizes them according to the concept of tunability. Micro-optofluidic lenses can be either tuned by the liquid in use or by the shape of the lens. Micro-optofluidic lenses with tunable shape are categorized according to the actuation schemes. Typical parameters of micro-optofluidic lenses reported recently are compared and discussed. Finally, perspectives are given for future works in this field. PMID:20714369

Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

PubMed Central

Kim, Sung Eun; Park, Moo In; Park, Seun Ja; Moon, Won; Kim, Jae Hyun; Jung, Kyoungwon; Kim, Hae Koo; Lee, Young Dal

2017-01-01

AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure. METHODS This study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and tetracycline. RESULTS The overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with H. pylori eradication therapy failure. CONCLUSION The second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure. PMID:28246480

Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.

PubMed

Horvath, Gyongyi; Kekesi, Gabriella; Tuboly, Gabor; Benedek, Gyorgy

2007-06-25

A very interesting and rapidly developing field of pain research is related to the roles of different endogenous ligands. This study determined the antinociceptive interactions of triple and quadruple combinations of different endogenous ligands (endomorphin-1, adenosine, agmatine and kynurenic acid) on carrageenan-induced inflammatory pain model at the spinal level. Intrathecal infusion (60 min) of these drugs alone, in double, triple or quadruple combinations, was followed by a 60-min observation period. During the infusion, antihyperalgesic effect of 0.3 microg/min endomorphin-1 was higher in the triple combinations than those in the double combinations. After cessation of drug administration, only the combination of 0.3 microg/min endomorphin-1, 1 microg/min agmatine, and 0.3 microg/min adenosine was more effective than the double combinations. In quadruple combinations, the antinociceptive effects of both 0.1 and 0.3 microg/min endomorphin-1 were significantly potentiated by the otherwise ineffective triple combination of adenosine, agmatine, and kynurenic acid. No side effects could be observed at these doses. These results demonstrate that triple and quadruple combinations of these endogenous ligands caused more effective antihyperalgesia compared with double combinations. Accordingly, the doses of these substances could be further reduced, thus, reinforcing the view that complex activation and/or inhibition of different systems can be sufficiently effective in blocking nociception without adverse effects. Because all of these drugs had effects on various receptors and systems, the possible types of these interactions were discussed.

Terahertz Brewster lenses.

PubMed

Wichmann, Matthias; Scherger, Benedikt; Schumann, Steffen; Lippert, Sina; Scheller, Maik; Busch, Stefan F; Jansen, Christian; Koch, Martin

2011-12-05

Typical lenses suffer from Fresnel reflections at their surfaces, reducing the transmitted power and leading to interference phenomena. While antireflection coatings can efficiently suppress these reflections for a small frequency window, broadband antireflection coatings remain challenging. In this paper, we report on the simulation and experimental investigation of Brewster lenses in the THz-range. These lenses can be operated under the Brewster angle, ensuring reflection-free transmission of p-polarized light in an extremely broad spectral range. Experimental proof of the excellent focusing capabilities of the Brewster lenses is given by frequency and spatially resolved focus plane measurements using a fiber-coupled THz-TDS system.

Aspherics in spectacle lenses

NASA Astrophysics Data System (ADS)

Dürsteler, Juan Carlos

2016-12-01

A review of the use of aspherics in the last decades, understood in a broad sense as encompassing single-vision lenses with conicoid surfaces and free-form and progressive addition lenses (PALs) as well, is provided. The appearance of conicoid surfaces to correct aphakia and later to provide thinner and more aesthetically appealing plus lenses and the introduction of PALs and free-form surfaces have shaped the advances in spectacle lenses in the last three decades. This document basically considers the main target optical aberrations, the idiosyncrasy of single lenses for correction of refractive errors and the restrictions and particularities of PAL design and their links to science vision and perception.

Berberine containing quadruple therapy for initial Helicobacter pylori eradication: An open-label randomized phase IV trial.

PubMed

Zhang, Di; Ke, Li; Ni, Zhen; Chen, Yu; Zhang, Lin-Hui; Zhu, Shao-Hua; Li, Chan-Juan; Shang, Lei; Liang, Jie; Shi, Yong-Quan

2017-08-01

Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for H pylori eradication. In a randomized, open-label, non-inferiority, phase IV trial between November 25, 2014, and October 15, 2015, 612 treatment-naive patients were randomly assigned to 14-day berberine-containing (n = 308) or 14-day bismuth-containing (n = 304) quadruple therapy. The primary outcomes were eradication rates determined by the C urea breath test (C-UBT) 28 days after the end of treatment. The secondary outcomes were adverse events and compliance. The baseline demographic data including age, gender, body mass index (BMI), general condition and severity score were not statistically different in both groups. The eradication rates in bismuth and berberine groups were 86.4% (266/308) and 90.1% (274/304) in intention-to-treat (ITT) analysis (P = .149), and 89.6% (266/297) and 91.3% (273/299) in per-protocol (PP) analysis (P = .470), respectively. No statistically significant difference was found in the overall incidence of adverse events between both groups (35.7% vs 28.6%, P = .060). Both regimens achieved the recommended efficacy for H pylori eradication. The berberine-containing quadruple regimen was not inferior to bismuth-containing quadruple regimen and can be recommended as an alternative regimen for H pylori eradication in the local region.

Analysis of luminosity distributions of strong lensing galaxies: subtraction of diffuse lensed signal

NASA Astrophysics Data System (ADS)

Biernaux, J.; Magain, P.; Hauret, C.

2017-08-01

Context. Strong gravitational lensing gives access to the total mass distribution of galaxies. It can unveil a great deal of information about the lenses' dark matter content when combined with the study of the lenses' light profile. However, gravitational lensing galaxies, by definition, appear surrounded by lensed signal, both point-like and diffuse, that is irrelevant to the lens flux. Therefore, the observer is most often restricted to studying the innermost portions of the galaxy, where classical fitting methods show some instabilities. Aims: We aim at subtracting that lensed signal and at characterising some lenses' light profile by computing their shape parameters (half-light radius, ellipticity, and position angle). Our objective is to evaluate the total integrated flux in an aperture the size of the Einstein ring in order to obtain a robust estimate of the quantity of ordinary (luminous) matter in each system. Methods: We are expanding the work we started in a previous paper that consisted in subtracting point-like lensed images and in independently measuring each shape parameter. We improve it by designing a subtraction of the diffuse lensed signal, based only on one simple hypothesis of symmetry. We apply it to the cases where it proves to be necessary. This extra step improves our study of the shape parameters and we refine it even more by upgrading our half-light radius measurement method. We also calculate the impact of our specific image processing on the error bars. Results: The diffuse lensed signal subtraction makes it possible to study a larger portion of relevant galactic flux, as the radius of the fitting region increases by on average 17%. We retrieve new half-light radii values that are on average 11% smaller than in our previous work, although the uncertainties overlap in most cases. This shows that not taking the diffuse lensed signal into account may lead to a significant overestimate of the half-light radius. We are also able to measure

An analytical approach to gravitational lensing by an ensemble of axisymmetric lenses

NASA Technical Reports Server (NTRS)

Lee, Man Hoi; Spergel, David N.

1990-01-01

The problem of gravitational lensing by an ensemble of identical axisymmetric lenses randomly distributed on a single lens plane is considered and a formal expression is derived for the joint probability density of finding shear and convergence at a random point on the plane. The amplification probability for a source can be accurately estimated from the distribution in shear and convergence. This method is applied to two cases: lensing by an ensemble of point masses and by an ensemble of objects with Gaussian surface mass density. There is no convergence for point masses whereas shear is negligible for wide Gaussian lenses.

Spatially Resolved Spectroscopy of the PMS Quadruple GG Tau: Evidence for a Substellar Companion

NASA Astrophysics Data System (ADS)

White, R. J.; Ghez, A. M.; Schultz, G.; Reid, I. N.

1998-05-01

We present spatially resolved optical spectra from HST (FOS) and the Keck Telescope (HIRES & LRIS) of the components of the quadruple PMS system GG Tau. According to the latest PMS evolutionary models, the coldest component of this system, GG Tau/c B, appears to be substellar with a preliminary mass of only 50 M_J. This putative brown dwarf is especially intriguing as it shows clear signatures of accretion. The components of this quadruple, which span a wide range in mass, are used to test theoretical low mass PMS evolutionary models under the assumption that the components should be coeval.

Gradient Refractive Index Lenses.

ERIC Educational Resources Information Center

Morton, N.

1984-01-01

Describes the nature of gradient refractive index (GRIN) lenses, focusing on refraction in these materials, focal length of a thin Wood lens, and on manufacturing of such lenses. Indicates that GRIN lenses of small cross section are in limited production with applications suggested for optical communication and photocopying fields. (JN)

Gravitational Lensing in Astronomy.

PubMed

Wambsganss, Joachim

1998-01-01

Deflection of light by gravity was predicted by General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically. Among them were: the possibility of multiple or ring-like images of background sources, the use of lensing as a gravitational telescope on very faint and distant objects, and the possibility of determining Hubble's constant with lensing. It is only relatively recently, (after the discovery of the first doubly imaged quasar in 1979), that gravitational lensing has became an observational science. Today lensing is a booming part of astrophysics. In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered: For example, giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, and weak gravitational lensing. At present, literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, the physics of quasars, dark matter in galaxy halos, and galaxy structure. Looking at these successes in the recent past we predict an even more luminous future for gravitational lensing. Supplementary material is available for this article at 10.12942/lrr-1998-12.

Ternary Polymeric Composites Exhibiting Bulk and Surface Quadruple-Shape Memory Properties.

PubMed

Buffington, Shelby Lois; Posnick, Benjamin M; Paul, Justine Elizabeth; Mather, Patrick T

2018-06-19

We report the design and characterization of a multiphase quadruple shape memory composite capable of switching between 4 programmed shapes, three temporary and one permanent. Our approach combined two previously reported fabrication methods by embedding an electrospun mat of PCL in a miscible blend of epoxy monomers and PMMA as a composite matrix. As epoxy polymerization occurred the matrix underwent phase separation between the epoxy and PMMA materials. This created a multiphase composite with PCL fibers and a two-phase matrix composed of phase-separated epoxy and PMMA. The resulting composite demonstrated three separate thermal transitions and amenability to mechanical programming of three separate temporary shapes in addition to one final, equilibrium shape. In addition, quadruple surface shape memory abilities are successfully demonstrated. The versatility of this approach offers a large degree of design flexibility for multi-shape memory materials. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Andromeda’s Parachute: A Bright Quadruply Lensed Quasar at z = 2.377

NASA Astrophysics Data System (ADS)

Rubin, Kate H. R.; O’Meara, John M.; Cooksey, Kathy L.; Matuszewski, Mateusz; Rizzi, Luca; Doppmann, Greg; Kwok, Shui; Martin, D. Christopher; Moore, Anna M.; Morrissey, Patrick; Neill, James D.

2018-06-01

We present Keck Cosmic Web Imager spectroscopy of the four putative images of the lensed quasar candidate J014710+463040 recently discovered by Berghea et al. The data verify the source as a quadruply lensed, broad absorption-line quasar having {z}{{S}}=2.377 +/- 0.007. We detect intervening absorption in the Fe II λλ2586, 2600, Mg II λλ2796, 2803, and/or C IV λλ1548, 1550 transitions in eight foreground systems, three of which have redshifts consistent with the photometric-redshift estimate reported for the lensing galaxy (z L ≈ 0.57). The source images probe these absorbers over transverse physical scales of ≈0.3–22 kpc, permitting assessment of the variation in metal-line equivalent width {W}{{r}} as a function of sight-line separation. We measure differences in {W}{{r},2796} of <40% across most of the sight-line pairs subtending 8–22 kpc, suggestive of a high degree of spatial coherence for the Mg II-absorbing material. {W}{{r},2600} varies by >50% over the same scales across the majority of sight-line pairs, while C IV absorption exhibits a wide range in {W}{{r},1548} differences of ≈5%–80% within transverse distances of ≲3 kpc. These spatial variations are consistent with those measured in intervening absorbers detected toward lensed quasars drawn from the literature, in which {W}{{r},2796} and {W}{{r},1548} vary by ≤20% in 35 ± 7% and 47 ± 6% of sight lines separated by <10 kpc, respectively. J014710+463040 is one of only a handful of z > 2 quadruply lensed systems for which all four source images are very bright (r = 15.4–17.7 mag) and are easily separated in ground-based seeing conditions. As such, it is an ideal candidate for higher-resolution spectroscopy probing the spatial variation in the kinematic structure and physical state of intervening absorbers.

OT2_eegami_6: SPIRE Snapshot Survey II: Using SPT/CODEX Massive Clusters as Powerful Gravitational Lenses

NASA Astrophysics Data System (ADS)

Egami, E.

2011-09-01

On the extragalactic side, one of the most remarkable results coming out of Herschel is the discovery of extremely bright (>100 mJy in the SPIRE bands) gravitationally lensed galaxies. The great sensitivity and mapping speed of SPIRE have enabled us to find these rare extraordinary objects. What is truly exciting about these bright lensed galaxies is that they enable a variety of detailed multi-wavelength follow-up observations, shedding new light on the physical properties of these high-redshift sources. In this regard, our OT1 program, "SPIRE Snapshot Survey of Massive Galaxy Clusters" turned out to be a great success. After imaging ~50 galaxies out of 279 in the program, we have already found two spectacularly bright lensed galaxies, one of which is at a redshift of 4.69. This type of cluster-lensed sources are not only bright but also spatially stretched over a large scale, so ALMA (or NOEMA in the north) is likely to be able to study them at the level of individual GMCs. Such studies will open up a new frontier in the study of high-redshift galaxies. Here, we propose to extend this highly efficient and effective survey of gravitationally lensed galaxies to another 353 clusters carefully chosen from the SPT and CODEX cluster samples. These samples contain newly discovered high-redshift (z>0.3) massive (>3-4e14 Msun) clusters, which can be used as powerful gravitational lenses to magnify sources at high redshift. With the OT1 and OT2 surveys together, we expect to find ~20 highly magnified SPIRE sources with exceptional brightnesses (assuming a discovery rate of ~1/30). Such a unique sample of extraordinary objects will enable a variety of follow-up sciences, and will therefore remain as a great legacy of the Herschel mission for years to come.

Design of an electron projection system with slider lenses and multiple beams

NASA Astrophysics Data System (ADS)

Moonen, Daniel; Leunissen, Peter L. H. A.; de Jager, Patrick W.; Kruit, Pieter; Bleeker, Arno J.; Van der Mast, Karel D.

2002-07-01

The commercial applicability of electron beam projection lithography systems may be limited at high resolution because of low throughput. The main limitations to the throughput are: (i) Beam current. The Coulomb interaction between electrons result in an image blue. Therefore less beam current can be allowed at higher resolution, impacting the illuminate time of the wafer. (ii) Exposure field size. Early attempts to improve throughput with 'full chip' electron beam projection systems failed, because the system suffered from large off-axis aberrations of the electron optics, which severely restricted the useful field size. This has impact on the overhead time. A new type of projection optics will be proposed in this paper to overcome both limits. A slider lens is proposed that allows an effective field that is much larger than schemes proposed by SCALPEL and PREVAIL. The full width of the die can be exposed without mechanical scanning by sliding the beam through the slit-like bore of the lens. Locally, at the beam position, a 'round'-lens field is created with a combination of a rectangular magnetic field and quadruples that are positioned inside the lens. A die can now be exposed during a single mechanical scan as in state-of-the-art light optical tools. The total beam current can be improved without impact on the Coulomb interaction blur by combining several beams in a single lithography system if these beams do not interfere with each other. Several optical layouts have been proposed that combined up to 5 beams in a projection system consisting of a doublet of slider lenses. This type of projection optics has a potential throughput of 50 WPH at 45 nm with a resist sensitivity of 6 (mu) C/cm2.

Binary Lenses in OGLE-III EWS Database. Seasons 2002-2003

NASA Astrophysics Data System (ADS)

Jaroszynski, M.; Udalski, A.; Kubiak, M.; Szymanski, M.; Pietrzynski, G.; Soszynski, I.; Zebrun, K.; Szewczyk, O.; Wyrzykowski, L.

2004-06-01

We present 15 binary lens candidates from OGLE-III Early Warning System database for seasons 2002-2003. We also found 15 events interpreted as single mass lensing of double sources. The candidates were selected by visual light curves inspection. Examining the models of binary lenses of this and our previous study (10 caustic crossing events of OGLE-II seasons 1997--1999) we find one case of extreme mass ratio binary (q approx 0.005) and the rest in the range 0.1

Weak Gravitational Lensing

NASA Astrophysics Data System (ADS)

Pires, Sandrine; Starck, Jean-Luc; Leonard, Adrienne; Réfrégier, Alexandre

2012-03-01

This chapter reviews the data mining methods recently developed to solve standard data problems in weak gravitational lensing. We detail the different steps of the weak lensing data analysis along with the different techniques dedicated to these applications. An overview of the different techniques currently used will be given along with future prospects. Until about 30 years ago, astronomers thought that the Universe was composed almost entirely of ordinary matter: protons, neutrons, electrons, and atoms. The field of weak lensing has been motivated by the observations made in the last decades showing that visible matter represents only about 4-5% of the Universe (see Figure 14.1). Currently, the majority of the Universe is thought to be dark, that is, does not emit electromagnetic radiation. The Universe is thought to be mostly composed of an invisible, pressure less matter - potentially relic from higher energy theories - called "dark matter" (20-21%) and by an even more mysterious term, described in Einstein equations as a vacuum energy density, called "dark energy" (70%). This "dark" Universe is not well described or even understood; its presence is inferred indirectly from its gravitational effects, both on the motions of astronomical objects and on light propagation. So this point could be the next breakthrough in cosmology. Today's cosmology is based on a cosmological model that contains various parameters that need to be determined precisely, such as the matter density parameter Omega_m or the dark energy density parameter Omega_lambda. Weak gravitational lensing is believed to be the most promising tool to understand the nature of dark matter and to constrain the cosmological parameters used to describe the Universe because it provides a method to directly map the distribution of dark matter (see [1,6,60,63,70]). From this dark matter distribution, the nature of dark matter can be better understood and better constraints can be placed on dark energy

Stress-Detection Lenses

NASA Technical Reports Server (NTRS)

1996-01-01

An Ames Research Center scientist invented an infrared lens used in sunglasses to filter out ultraviolet rays. This product finds its origins in research for military enemy detection. Through a Space Act Agreement, Optical Sales Corporation introduced the Hawkeye Lenses not only as sunglasses but as plant stress detection lenses. The lenses enhance the stressed part of the leaf, which has less chlorophyll than healthy leaves, through dyes that filter out certain wavelengths of light. Plant stress is visible earlier, at a stage when something can be done to save the plants.

Simultaneous quadruple modal nonlinear optical imaging for gastric diseases diagnosis and characterization

NASA Astrophysics Data System (ADS)

Wang, Zi; Zheng, Wei; Lin, Jian; Huang, Zhiwei

2015-03-01

We report the development of a unique simultaneous quadruple-modal nonlinear optical microscopy (i.e., stimulated Raman scattering (SRS), second-harmonic generation (SHG), two-photon excitation fluorescence (TPEF), and third-harmonic generation (THG)) platform for characterization of the gastric diseases (i.e., gastritis, intestinal metaplasia (IM), intestinal type adenocarcinoma). SRS highlights the goblet cells found in IM. SHG images the distribution of collagen in lamina propria. Collagen is found to aggregate for intestinal type adenocarcinoma. TPEF reveals the cell morphology and can reflect the damage inside glands caused by the diseases. THG visualizes the nuclei with high spatial resolution, which facilitates the identification of neutrophils that are usually used as a feature of inflammation. This work shows that the co-registration of quadruple-modal images can be an effective means for diagnosis and characterization of gastric diseases at the cellular and molecular levels.

Additive manufacturing of tunable lenses

NASA Astrophysics Data System (ADS)

Schlichting, Katja; Novak, Tobias; Heinrich, Andreas

2017-02-01

Individual additive manufacturing of optical systems based on 3D Printing offers varied possibilities in design and usage. In addition to the additive manufacturing procedure, the usage of tunable lenses allows further advantages for intelligent optical systems. Our goal is to bring the advantages of additive manufacturing together with the huge potential of tunable lenses. We produced tunable lenses as a bundle without any further processing steps, like polishing. The lenses were designed and directly printed with a 3D Printer as a package. The design contains the membrane as an optical part as well as the mechanical parts of the lens, like the attachments for the sleeves which contain the oil. The dynamic optical lenses were filled with an oil. The focal length of the lenses changes due to a change of the radius of curvature. This change is caused by changing the pressure in the inside of the lens. In addition to that, we designed lenses with special structures to obtain different areas with an individual optical power. We want to discuss the huge potential of this technology for several applications. Further, an appropriate controlling system is needed. Wéll show the possibilities to control and regulate the optical power of the lenses. The lenses could be used for illumination tasks, and in the future, for individual measurement tasks. The main advantage is the individuality and the possibility to create an individual design which completely fulfills the requirements for any specific application.

DeepLensing: The Use of Deep Machine Learning to Find Strong Gravitational Lenses in Astronomical Surveys

NASA Astrophysics Data System (ADS)

Nord, Brian

2017-01-01

Strong gravitational lenses have potential as very powerful probes of dark energy and cosmic structure. However, efficiently finding lenses poses a significant challenge—especially in the era of large-scale cosmological surveys. I will present a new application of deep machine learning algorithms to find strong lenses, as well as the strong lens discovery program of the Dark Energy Survey (DES).Strong lenses provide unique information about the evolution of distant galaxies, the nature of dark energy, and the shapes of dark matter haloes. Current and future surveys, like DES and the Large Synoptic Survey Telescope, present an opportunity to find many thousands of strong lenses, far more than have ever been discovered. By and large, searches have heretofore relied on the time-consuming effort of human scanners. Deep machine learning frameworks, like convolutional neural nets, have revolutionized the task of image recognition, and have a natural place in the processing of astronomical images, including the search for strong lenses.Over five observing seasons, which started in August 2013, DES will carry out a wide-field survey of 5000 square degrees of the Southern Galactic Cap. DES has identified nearly 200 strong lensing candidates in the first two seasons of data. We have performed spectroscopic follow-up on a subsample of these candidates at Gemini South, confirming over a dozen new strong lenses. I will present this DES discovery program, including searches and spectroscopic follow-up of galaxy-scale, cluster-scale and time-delay lensing systems.I will focus, however, on a discussion of the successful search for strong lenses using deep learning methods. In particular, we show that convolutional neural nets present a new set of tools for efficiently finding lenses, and accelerating advancements in strong lensing science.

Prescription compliance in ophthalmic lenses.

PubMed

Yuen, Gloria S-C; Chou, B Ralph; Ngo, Thao Pt; Cheng, Brian B; Dain, Stephen J

2011-07-01

Tolerances required for ophthalmic lenses are set down in national and international standards. It appears that the compliance of manufactured lenses has not been reported previously. Assembling a statistical quantity of lenses of a single prescription is usually an expensive process. It was, secondary to a lens impact study, possible to assemble a large number of plano lenses. In the assessment of the fracture velocity of lenses approximately 20 plano lenses of each material and thickness are required. Prior to using lenses for the impact study, they were checked for prescription. The results of the prescription measurements are reported here and the results of the impact study are reported in a separate paper. Using an automated focimeter, 679 plano lenses in stock thickness, typical occupational eye protector thickness and up to 3.5 mm thick were measured. There were 21 combinations of material/thickness/coating from seven suppliers. The power was evaluated against Australian Standard 2228.1-1992, as the lenses were supplied in Australia. The permitted tolerances are ±0.09 D sphere and ±0.06 D cylinder. When assessed for material/thickness/coating combination, failure rates varied from <0.0001 per cent to 77.5 per cent (with a further 17.3 per cent classified as borderline, because they were within the uncertainty of measurement of the required limit). Grouped by supplier, the failure rates ranged from <0.0001 per cent to 7.6 per cent (with a further 12.3 per cent borderline). To improve understanding of the result, it may be easier to quote the figures without considering uncertainties. When assessed by supplier, the failure rate varies from <0.0001 per cent to 12.6 per cent. Compliance of plano lenses should be among the easiest of tasks for a laboratory. While we know of no defined or required acceptance rates for prescription lenses, a failure rate for a laboratory of 12.6 per cent, which includes a failure rate of 88 per cent in 2.8 mm thick refractive

Standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori eradication

PubMed Central

Gao, Xiao-Zhong; Qiao, Xiu-Li; Song, Wen-Chong; Wang, Xiao-Feng; Liu, Feng

2010-01-01

AIM: To compare the effectiveness of standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori (H. pylori) eradication in a randomized, double-blinded, comparative clinical trial in China. METHODS: A total of 215 H. pylori-positive patients were enrolled in the study and randomly allocated into three groups: group A (n = 72) received a 10-d bismuth pectin quadruple therapy (20 mg rabeprazole bid, 1000 mg amoxicillin bid, 100 mg bismuth pectin qid, and 500 mg levofloxacin qd); group B (n = 72) received the sequential therapy (20 mg omeprazole bid, 1000 mg amoxicillin bid, in 5 d, followed by 20 mg omeprazole bid, 500 mg tinidazole bid, 500 mg clarithromycin bid, for another 5 d); group C (n = 71) received a standard 1-wk triple therapy (20 mg omeprazole bid, 1000 mg amoxicillin bid, 500 mg clarithromycin bid). After all these treatments, 20 mg omeprazole bid was administrated for 3 wk. H. pylori status was assessed by histology, 13C-urea breath test and rapid urease test at baseline and 4-6 wk after completion of treatment. Ulcer cicatrization was assessed by gastroscopy. χ2 test (P < 0.05) was used to compare the eradication rates and ulcer cicatrisation rates among the three groups. RESULTS: The eradication rate was 83.33% (60/72) in group A, 88.89% (64/72) in group B, and 80.56% (58/71) in group C. The ulcer cicatrisation rate was 86.44% (51/59) in group A, 90.16% (55/61) in group B, and 84.91% (45/53) in group C. The sequential therapy yielded a higher eradication rate and ulcer cicatrisation rate than the standard triple and bismuth pectin quadruple therapies. Statistically, the eradication rate of group B was significantly different from groups A and C (P < 0.05), but the difference of ulcer cicatrisation rate and side effects was not statistically significant among the three groups (P > 0.05). The three protocols were generally well tolerated. CONCLUSION: The sequential therapy has achieved a significantly higher eradication

Shatter resistance of spectacle lenses.

PubMed

Vinger, P F; Parver, L; Alfaro, D V; Woods, T; Abrams, B S

1997-01-08

To evaluate the relative strength and shatter resistance of spectacle lenses currently used in sunglasses and dress, sports, and industrial eyewear. Seven lenses that met the US American National Standards Institute (ANSI) Z80 standards for dress glasses (made of high-index plastic, allyl resin plastic, heat tempered glass, chemically tempered glass, and polycarbonate, and with center thickness ranging from 1 mm to 2.2 mm) and 4 lenses that met ANSI Z87 standards for industrial safety eyewear (allyl resin plastic, heat-tempered glass, chemically tempered glass, and polycarbonate, all with 3.0-mm center thickness) were tested for impact resistance to 5 projectiles (air gun pellets, golf balls, tennis balls, lacrosse balls, and baseballs). Impact energy required to shatter spectacle lenses. Based on 348 lens impacts, dress and industrial lenses made from glass, allyl resin plastic, and high-index plastic shattered at impact energies less than those expected to be encountered from the test projectiles during their routine use. Polycarbonate lenses demonstrated resistance to impact for all tested projectiles exceeding the impact potential expected during routine use. Under the test conditions of this study, polycarbonate lenses demonstrated greater impact resistance than other commonly used spectacle lenses that conform to prevailing eyewear standards. These findings suggest that current ANSI Z80 and ANSI Z87 standards should be reevaluated.

Dynamics of quadruple systems composed of two binaries: stars, white dwarfs, and implications for Ia supernovae

NASA Astrophysics Data System (ADS)

Fang, Xiao; Thompson, Todd A.; Hirata, Christopher M.

2018-05-01

We investigate the long-term secular dynamics and Lidov-Kozai (LK) eccentricity oscillations of quadruple systems composed of two binaries at quadrupole and octupole orders in the perturbing Hamiltonian. We show that the fraction of systems reaching high eccentricities is enhanced relative to triple systems, over a broader range of parameter space. We show that this fraction grows with time, unlike triple systems evolved at quadrupole order. This is fundamentally because with their additional degrees of freedom, quadruple systems do not have a maximal set of commuting constants of the motion, even in secular theory at quadrupole order. We discuss these results in the context of star-star and white dwarf-white dwarf (WD) binaries, with emphasis on WD-WD mergers and collisions relevant to the Type Ia supernova problem. For star-star systems, we find that more than 30 per cent of systems reach high eccentricity within a Hubble time, potentially forming triple systems via stellar mergers or close binaries. For WD-WD systems, taking into account general relativistic and tidal precession and dissipation, we show that the merger rate is enhanced in quadruple systems relative to triple systems by a factor of 3.5-10, and that the long-term evolution of quadruple systems leads to a delay-time distribution ˜1/t for mergers and collisions. In gravitational wave-driven mergers of compact objects, we classify the mergers by their evolutionary patterns in phase space and identify a regime in about 8 per cent of orbital shrinking mergers, where eccentricity oscillations occur on the general relativistic precession time-scale, rather than the much longer LK time-scale. Finally, we generalize previous treatments of oscillations in the inner binary eccentricity (evection) to eccentric mutual orbits. We assess the merger rate in quadruple and triple systems and the implications for their viability as progenitors of stellar mergers and Type Ia supernovae.

Antibacterial activity of contact lenses bearing surface-immobilized layers of intact liposomes loaded with levofloxacin.

PubMed

Danion, Anne; Arsenault, Isabelle; Vermette, Patrick

2007-09-01

In vitro methods to evaluate antibacterial activity were used with contact lenses bearing levofloxacin-loaded liposomes developed for the prevention and treatment of bacterial ocular infections such as keratitis. Levofloxacin was incorporated into liposomes before these intact liposomes were immobilized onto the surfaces of soft contact lenses using a multilayer immobilization strategy. The release of levofloxacin from contact lenses bearing 2, 5, and 10 layers of liposomes into a saline buffer at 37 degrees C was monitored by fluorescence. The levofloxacin release, as a function of time, was described by a mechanism taking into account two independent first-order kinetic models. The total release of levofloxacin from the contact lenses was completed within 6 days. The release of levofloxacin from contact lenses bearing 10 layers of liposomes and subsequently soaked overnight in a levofloxacin solution was also studied and compare to that of dried contact lenses without any chemical modification rehydrated in a levofloxacin solution. The antibacterial activity of the liposome-coated contact lenses against Staphylococcus aureus was evaluated by measuring (i) the diameters of the inhibition zone on an agar plate and (ii) the optical density using a broth assay. The liposome-coated lenses showed an antibacterial activity both on agar and in broth following 24 h. When initial bacteria inocula were equal or below 10(6) CFU/mL, all the bacteria were inhibited within 2 h. When using initial bacteria inocula of 10(8) CFU/mL, an initial burst release provided by soaking the liposomal lenses was required for the first hours to inhibit bacteria growth. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

Understanding Quadruple Helix Relationships of University Technology Commercialisation: A Micro-Level Approach

ERIC Educational Resources Information Center

McAdam, Maura; Miller, Kristel; McAdam, Rodney

2018-01-01

Given recent demands for more co-creational university technology commercialisation processes involving industry and end users, this paper adopts a micro-level approach to explore the challenges faced by universities when managing Quadruple Helix stakeholders within technology commercialisation processes. To explore this research question, a…

Gravitational Lensing in Astronomy

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

1998-11-01

In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered: For example, giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, and weak gravitational lensing. At present, literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, the physics of quasars, dark matter in galaxy halos, and galaxy structure. Looking at these successes in the recent past we predict an even more luminous future for gravitational lensing.

Biocompatibility and light transmission of liposomal lenses.

PubMed

Danion, Anne; Doillon, Charles J; Giasson, Claude J; Djouahra, Saliha; Sauvageau, Patrick; Paradis, Renée; Vermette, Patrick

2007-10-01

To validate the biocompatibility and transmittance properties of contact lenses bearing intact liposomes. These liposomal lenses loaded with therapeutics can be used as ophthalmic drug delivery systems. The biocompatibility of soft contact lenses, coated with liposomes was evaluated through in vitro direct and indirect cytocompatibility assays on human corneal epithelial cells, on reconstructed human corneas and on ex vivo rabbit corneas. The direct and indirect transmission spectra of liposome-covered lenses were also evaluated to test if they transmit all wavelengths of the ultraviolet-visible spectrum, to thereby fulfill their optical function, without gross alteration of the colors perception and with a minimum of light dispersion. Contact lenses bearing layers of stable liposomes did not induce any significant changes in cell viability and in cell growth, compared with lenses bearing no liposome. Elution assays revealed that no cytotoxic compound leaks from the lenses whether bearing liposomes or not. Histological analyses of reconstructed human corneas and ex vivo rabbit corneas directly exposed to liposomal lenses revealed neither alteration to the cell nor to the tissue structures. Contact lenses bearing layers of liposomes did not significantly affect light transmission compared with control lenses without liposome at the wavelength of maximal photopic sensitivity, i.e., 550 nm. In addition, the contact lenses afford more eye protection in the ultraviolet spectrum, compared with the control lenses. Liposomal contact lenses are biocompatible and their transmittance properties are not affected in the visible light range.

Gravitational Lensing 2.0

NASA Astrophysics Data System (ADS)

Wittman, David M.; Benson, Bryant

2018-06-01

Weak lensing analyses use the image---the intensity field---of a distant galaxy to infer gravitational effects on that line of sight. What if we analyze the velocity field instead? We show that lensing imprints much more information onto a highly ordered velocity field, such as that of a rotating disk galaxy, than onto an intensity field. This is because shuffling intensity pixels yields a post-lensed image quite similar to an unlensed galaxy with a different orientation, a problem known as "shape noise." We show that velocity field analysis can eliminate shape noise and yield much more precise lensing constraints. Furthermore, convergence as well as shear can be constrained using the same target, and there is no need to assume the weak lensing limit of small convergence. We present Fisher matrix forecasts of the precision achievable with this method. Velocity field observations are expensive, so we derive guidelines for choosing suitable targets by exploring how precision varies with source parameters such as inclination angle and redshift. Finally, we present simulations that support our Fisher matrix forecasts.

30 CFR 18.30 - Windows and lenses.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Windows and lenses. 18.30 Section 18.30 Mineral... § 18.30 Windows and lenses. (a) MSHA may waive testing of materials for windows or lenses except headlight lenses. When tested, material for windows or lenses shall meet the test requirements prescribed in...

A new model to predict weak-lensing peak counts. II. Parameter constraint strategies

NASA Astrophysics Data System (ADS)

Lin, Chieh-An; Kilbinger, Martin

2015-11-01

Context. Peak counts have been shown to be an excellent tool for extracting the non-Gaussian part of the weak lensing signal. Recently, we developed a fast stochastic forward model to predict weak-lensing peak counts. Our model is able to reconstruct the underlying distribution of observables for analysis. Aims: In this work, we explore and compare various strategies for constraining a parameter using our model, focusing on the matter density Ωm and the density fluctuation amplitude σ8. Methods: First, we examine the impact from the cosmological dependency of covariances (CDC). Second, we perform the analysis with the copula likelihood, a technique that makes a weaker assumption than does the Gaussian likelihood. Third, direct, non-analytic parameter estimations are applied using the full information of the distribution. Fourth, we obtain constraints with approximate Bayesian computation (ABC), an efficient, robust, and likelihood-free algorithm based on accept-reject sampling. Results: We find that neglecting the CDC effect enlarges parameter contours by 22% and that the covariance-varying copula likelihood is a very good approximation to the true likelihood. The direct techniques work well in spite of noisier contours. Concerning ABC, the iterative process converges quickly to a posterior distribution that is in excellent agreement with results from our other analyses. The time cost for ABC is reduced by two orders of magnitude. Conclusions: The stochastic nature of our weak-lensing peak count model allows us to use various techniques that approach the true underlying probability distribution of observables, without making simplifying assumptions. Our work can be generalized to other observables where forward simulations provide samples of the underlying distribution.

Gravitational lenses, cosmology, and galaxy structure

NASA Astrophysics Data System (ADS)

Winn, J.

2002-05-01

Gravitational lenses can be used to study dark matter in galaxies and to measure the Hubble constant. The statistics of lensing can be used to measure the cosmological constant. I have been conducting a survey of the southern sky for new lenses at radio wavelengths, which has resulted in 4 confirmed lenses and 3 strong candidates that require further follow-up. I will describe the survey and the scientific results that have been obtained from the new lenses. I will also describe my other life as a science journalist.

[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].

PubMed

Gao, Wen; Hu, Fulian; Cheng, Hong; Wang, Huahong; Yang, Yunsheng; Liang, Hao; Zhang, Shutian; Meng, Fandong; Cui, Meihua; Wei, Hong; Sheng, Jianqiu; An, Hejuan J; Jiang, Bo; Chen, Ye; Li, Yanqing; Zuo, Xiuli; Gong, Jun; Zhao, Ping; Dong, Lei; Wang, Bangmao; Jiang, Kai; Zhang, Guiying; Li, Jiansheng; Zhao, Ye; Gao, Hengjun; Yang, Li

2016-01-26

To observe the effects and safety of quadruple regimens including domestically manufactured rabeprazole used as first line/initial therapy for Helicobacter pylori(H.pylori) eradication in gastritis and duodenal ulcer patients, and to investigate the effects of extended use of bismuth after the quadruple therapy on eradication of H. pylori. From January to August 2013, 430 patients with chronic gastritis or duodenal ulcer who were confirmed as H. pylori positive in gastroscopy for upper gastrointestinal symptoms were enrolled from 12 centers in China for initial treatment using quadruple regimens for H. pylori eradication. The study was a prospective, multicenter, randomized double-blinded double-dummy parallel-controlled clinical trial. The 310 chronic gastritis patients were divided into 2 groups: group A1 was given quadruple regime (rabeprazole+ amoxicillin+ clarithromycin+ bismuth potassium citrate) for 10 days followed by bismuth-placebo for 21 days; group A2 was given the quadruple regimen for 10 days and then bismuth potassium citrate for 21 days. The duodenal ulcer patients were given the quadruple for 10 days, then rabeprazole for 14 days. All the patients took (13)C urea breath test to detect H. pylori 28 days after medicine withdrawal. Altogether 428 cases were enrolled and 404 completed the trial. The total eradication rate in the chronic gastritis patients was 85.1% (262/308, intention-to-treat (ITT)analysis), which was 81.7% (125/153, ITT) in the A1 group and 88.4% (137/155, ITT) in the A2 group; the eradication rate in the duodenal ulcer patients was 85.8% (103/120, ITT). No severe adverse effects were reported. The symptoms (pain, burning sensation, reflux, belching, nausea, and vomiting) improvement status was similar among A1 and A2 groups. The quadruple regimen using rabeprazole manufactured in China and administered for 10 days as first line/initial therapy in chronic gastritis and duodenal ulcer patients could achieve good H. pylori eradication

Weak Lensing Study in VOICE Survey II: Shear Bias Calibrations

NASA Astrophysics Data System (ADS)

Liu, Dezi; Fu, Liping; Liu, Xiangkun; Radovich, Mario; Wang, Chao; Pan, Chuzhong; Fan, Zuhui; Covone, Giovanni; Vaccari, Mattia; Botticella, Maria Teresa; Capaccioli, Massimo; De Cicco, Demetra; Grado, Aniello; Miller, Lance; Napolitano, Nicola; Paolillo, Maurizio; Pignata, Giuliano

2018-05-01

The VST Optical Imaging of the CDFS and ES1 Fields (VOICE) Survey is proposed to obtain deep optical ugri imaging of the CDFS and ES1 fields using the VLT Survey Telescope (VST). At present, the observations for the CDFS field have been completed, and comprise in total about 4.9 deg2 down to rAB ˜ 26 mag. In the companion paper by Fu et al. (2018), we present the weak lensing shear measurements for r-band images with seeing ≤ 0.9 arcsec. In this paper, we perform image simulations to calibrate possible biases of the measured shear signals. Statistically, the properties of the simulated point spread function (PSF) and galaxies show good agreements with those of observations. The multiplicative bias is calibrated to reach an accuracy of ˜3.0%. We study the bias sensitivities to the undetected faint galaxies and to the neighboring galaxies. We find that undetected galaxies contribute to the multiplicative bias at the level of ˜0.3%. Further analysis shows that galaxies with lower signal-to-noise ratio (SNR) are impacted more significantly because the undetected galaxies skew the background noise distribution. For the neighboring galaxies, we find that although most have been rejected in the shape measurement procedure, about one third of them still remain in the final shear sample. They show a larger ellipticity dispersion and contribute to ˜0.2% of the multiplicative bias. Such a bias can be removed by further eliminating these neighboring galaxies. But the effective number density of the galaxies can be reduced considerably. Therefore efficient methods should be developed for future weak lensing deep surveys.

Quantitation of total protein deposits on contact lenses by means of amino acid analysis.

PubMed

Yan, G; Nyquist, G; Caldwell, K D; Payor, R; McCraw, E C

1993-04-01

This study was done to characterize and quantify the protein deposits on worn contact lenses and to measure the residual deposits after extraction in 2% sodium dodecyl sulfate and the total protein deposits on worn vifilcon, atlafilcon, and tefilcon lenses (Food and Drug Administration Types IV, II, and I, respectively). Contact lens extracts were separated with gel electrophoresis, and the amount of protein was estimated after silver staining and densitometry. To determine the residual deposits, the contact lenses were hydrolyzed, and amino acid analysis was carried out by reverse-phase high-performance liquid chromatography after precolumn derivatization with phenylisothiocyanate. Refinement of the hydrolysis conditions was undertaken to minimize interference by the lens polymers. The extraction removed only approximately 25% of the protein deposits. Mild hydrolytic conditions, 20 hr in 6 N HCl at 105 degrees C, were found to cause minimal polymer interference. Of the 350, 10, and 20 micrograms of protein typically determined on whole vifilcon, atlafilcon, and tefilcon lenses, the polymers were estimated to account for 4, 0.5, and less than 0.4 micrograms, respectively. Hydrolysis of worn contact lenses with subsequent amino acid separation can be applied to determine the total protein deposits without the uncertainty inherent in extraction of the deposits.

Gravitational lenses and dark matter - Theory

NASA Technical Reports Server (NTRS)

Gott, J. Richard, III

1987-01-01

Theoretical models are presented for guiding the application of gravitational lenses to probe the characteristics of dark matter in the universe. Analytical techniques are defined for quantifying the mass associated with lensing galaxies (in terms of the image separation), determining the quantity of dark mass of the lensing bodies, and estimating the mass density of the lenses. The possibility that heavy halos are made of low mass stars is considered, along with the swallowing of central images of black holes or cusps in galactic nuclei and the effects produced on a lensed quasar image by nonbaryonic halos. The observable effects of dense groups and clusters and the characteristics of dark matter strings are discussed, and various types of images which are possible due to lensing phenomena and position are described.

Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation.

PubMed

Elanchezhian, R; Sakthivel, M; Isai, M; Geraldine, P; Thomas, P A

2009-07-31

To investigate whether acetyl-L-carnitine (ALCAR) retards L-buthionine-(S,R)-sulfoximine (BSO)-induced cataractogenesis in Wistar rat pups. On postpartum day 3, group I pups received intraperitoneal (ip) saline and group II and group III pups received i.p. injections of BSO once daily for three consecutive days. In addition, group III pups received ip ALCAR once daily from postpartum days 3-15. Both eyes of each pup were examined up from postpartum day 16 to day 30. After sacrifice, extricated pup lenses were analyzed for antioxidant and redox system components. There was dense lenticular opacification in all group II pups, minimal opacification in 40% of group III pups, and no opacification in 60% of group III pups and in all of group I pups. Group II lenses exhibited significantly lower values of antioxidant and redox system components and higher malondialdehyde concentrations than in group I or group III lenses. ALCAR prevents cataractogenesis in the BSO-induced cataract model, possibly by inhibiting depleting antioxidant enzyme and redox system components and inhibiting lipid peroxidation.

Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation

PubMed Central

Elanchezhian, R.; Sakthivel, M.; Isai, M.; Thomas, P.A.

2009-01-01

Purpose To investigate whether acetyl-L-carnitine (ALCAR) retards L-buthionine-(S,R)-sulfoximine (BSO)-induced cataractogenesis in Wistar rat pups. Methods On postpartum day 3, group I pups received intraperitoneal (ip) saline and group II and group III pups received i.p. injections of BSO once daily for three consecutive days. In addition, group III pups received ip ALCAR once daily from postpartum days 3–15. Both eyes of each pup were examined up from postpartum day 16 to day 30. After sacrifice, extricated pup lenses were analyzed for antioxidant and redox system components. Results There was dense lenticular opacification in all group II pups, minimal opacification in 40% of group III pups, and no opacification in 60% of group III pups and in all of group I pups. Group II lenses exhibited significantly lower values of antioxidant and redox system components and higher malondialdehyde concentrations than in group I or group III lenses. Conclusions ALCAR prevents cataractogenesis in the BSO-induced cataract model, possibly by inhibiting depleting antioxidant enzyme and redox system components and inhibiting lipid peroxidation. PMID:19649174

Planck 2015 results. XV. Gravitational lensing

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-09-01

We present the most significant measurement of the cosmic microwave background (CMB) lensing potential to date (at a level of 40σ), using temperature and polarization data from the Planck 2015 full-mission release. Using a polarization-only estimator, we detect lensing at a significance of 5σ. We cross-check the accuracy of our measurement using the wide frequency coverage and complementarity of the temperature and polarization measurements. Public products based on this measurement include an estimate of the lensing potential over approximately 70% of the sky, an estimate of the lensing potential power spectrum in bandpowers for the multipole range 40 ≤ L ≤ 400, and an associated likelihood for cosmological parameter constraints. We find good agreement between our measurement of the lensing potential power spectrum and that found in the ΛCDM model that best fits the Planck temperature and polarization power spectra. Using the lensing likelihood alone we obtain a percent-level measurement of the parameter combination σ8Ω0.25m = 0.591 ± 0.021. We combine our determination of the lensing potential with the E-mode polarization, also measured by Planck, to generate an estimate of the lensing B-mode. We show that this lensing B-mode estimate is correlated with the B-modes observed directly by Planck at the expected level and with a statistical significance of 10σ, confirming Planck's sensitivity to this known sky signal. We also correlate our lensing potential estimate with the large-scale temperature anisotropies, detecting a cross-correlation at the 3σ level, as expected because of dark energy in the concordance ΛCDM model.

Planck 2015 results: XV. Gravitational lensing

DOE PAGES

Ade, P. A. R.; Aghanim, N.; Arnaud, M.; ...

2016-09-20

Here, we present the most significant measurement of the cosmic microwave background (CMB) lensing potential to date (at a level of 40σ), using temperature and polarization data from the Planck 2015 full-mission release. Using a polarization-only estimator, we detect lensing at a significance of 5σ. We cross-check the accuracy of our measurement using the wide frequency coverage and complementarity of the temperature and polarization measurements. Public products based on this measurement include an estimate of the lensing potential over approximately 70% of the sky, an estimate of the lensing potential power spectrum in bandpowers for the multipole range 40 ≤more » L ≤ 400, and an associated likelihood for cosmological parameter constraints. We find good agreement between our measurement of the lensing potential power spectrum and that found in the ΛCDM model that best fits the Planck temperature and polarization power spectra. Using the lensing likelihood alone we obtain a percent-level measurement of the parameter combination σ 8Ω 0.25 m = 0.591 ± 0.021. We combine our determination of the lensing potential with the E-mode polarization, also measured by Planck, to generate an estimate of the lensing B-mode. We show that this lensing B-mode estimate is correlated with the B-modes observed directly by Planck at the expected level and with a statistical significance of 10σ, confirming Planck’s sensitivity to this known sky signal. Finally, we also correlate our lensing potential estimate with the large-scale temperature anisotropies, detecting a cross-correlation at the 3σ level, as expected because of dark energy in the concordance ΛCDM model.« less

[Contact lenses for children. Indications and results].

PubMed

Steinbach, P D; Nover, A

1976-03-18

If it is necessary to prescribe contact lenses for children, this correction should be made as soon as possible. As a consequence of the development of soft (hydrophile) lenses, the above mentioned group of patients has increased considerably. In any case, a monolateral aphakia as well as a manifest anisometropia should be corrected by a contact lense to avoid amblyopia, heterotropia and loss of stereoscopic vision. Usually soft lenses are well tolerated, so that patients suffering from aphakia as well as hyperopia should always use this type of lense. Nevertheless, the hard lense still has its indication in treating myopia and high astigmatism.

Research and analysis on new test lenses for calibration of focimeters used for measuring contact lenses

NASA Astrophysics Data System (ADS)

Zhang, Jiyan; Wang, Liru; Ma, Zhenya

2006-11-01

A focimeter is one of the basic ophthalmic instruments used in every optometric practice, and verification of the accuracy and calibration of the instrument are of the utmost importance. For many years the International Standardization for Organization requires that calibrations for all kinds of focimeters shall be accomplished by using test lenses described in ISO 9342:1996. These test lenses must be of high quality and of nominal back vertex power that is known with high accuracy. With the development of science and technology, ISO 9342 was revised in 2005. A new part ISO 9342-2 had been drafted for test lenses used to calibrate focimeters with contact lens measurement, and the original ISO 9342 was turned into the current ISO 9342-1, which could only be used to calibrate fociemters with spectacle lens measurement. As one of the standard drafters, the background for the newly published ISO 9342-2 is introduced in this study, and comparison between test lenses of ISO 9342-1 and ISO 9342-2 is made. Further, the influence of tolerance and uncertainty in design and production of standard test lenses of ISO 9342-2 is analyzed. The paraxial approximation is used to relate the lens parameters with back vertex power and to calculate the uncertainty budget. Moreover, one set of test lenses conforming to ISO 9342-2 is manufactured and experiments are done with it. Results show that test lenses described in ISO 9342-2 can correct the measurement errors of focimeters used for measuring contact lenses well, especially for spherical aberration, and the correction is more effective for spherical contact lenses with high back vertex power.

A VLT/NACO survey for triple and quadruple systems among visual pre-main sequence binaries

NASA Astrophysics Data System (ADS)

Correia, S.; Zinnecker, H.; Ratzka, Th.; Sterzik, M. F.

2006-12-01

Aims.This paper describes a systematic search for high-order multiplicity among wide visual Pre-Main Sequence (PMS) binaries. Methods: .We conducted an Adaptive Optics survey of a sample of 58 PMS wide binaries from various star-forming regions, which include 52 T Tauri systems with mostly K- and M-type primaries, with the NIR instrument NACO at the VLT. Results: .Of these 52 systems, 7 are found to be triple (2 new) and 7 quadruple (1 new). The new close companions are most likely physically bound based on their probability of chance projection and, for some of them, on their position on a color-color diagram. The corresponding degree of multiplicity among wide binaries (number of triples and quadruples divided by the number of systems) is 26.9 ± 7.2% in the projected separation range ~0.07 arcsec -12'', with the largest contribution from the Taurus-Auriga cloud. We also found that this degree of multiplicity is twice in Taurus compared to Ophiuchus and Chamaeleon for which the same number of sources are present in our sample. Considering a restricted sample composed of systems at distance 140-190 pc, the degree of multiplicity is 26.8 ± 8.1%, in the separation range 10/14 AU-1700/2300 AU (30 binaries, 5 triples, 6 quadruples). The observed frequency agrees with results from previous multiplicity surveys within the uncertainties, although a significant overabundance of quadruple systems compared to triple systems is apparent. Tentatively including the spectroscopic pairs in our restricted sample and comparing the multiplicity fractions to those measured for solar-type main-sequence stars in the solar neighborhood leads to the conclusion that both the ratio of triples to binaries and the ratio of quadruples to triples seems to be in excess among young stars. Most of the current numerical simulations of multiple star formation, and especially smoothed particles hydrodynamics simulations, over-predict the fraction of high-order multiplicity when compared to our

The statistics of gravitational lenses. III - Astrophysical consequences of quasar lensing

NASA Technical Reports Server (NTRS)

Ostriker, J. P.; Vietri, M.

1986-01-01

The method of Schmidt and Green (1983) for calculating the luminosity function of quasars is combined with gravitational-lensing theory to compute expected properties of lensed systems. Multiple quasar images produced by galaxies are of order 0.001 of the observed quasars, with the numbers over the whole sky calculated to be (0.86, 120, 1600) to limiting B magnitudes of (16, 19, 22). The amount of 'false evolution' is small except for an interesting subset of apparently bright, large-redshift objects for which minilensing by starlike objects may be important. Some of the BL Lac objects may be in this category, with the galaxy identified as the parent object really a foreground object within which stars have lensed a background optically violent variable quasar.

Designing future dark energy space missions. II. Photometric redshift of space weak lensing optimized surveys

NASA Astrophysics Data System (ADS)

Jouvel, S.; Kneib, J.-P.; Bernstein, G.; Ilbert, O.; Jelinsky, P.; Milliard, B.; Ealet, A.; Schimd, C.; Dahlen, T.; Arnouts, S.

2011-08-01

Context. With the discovery of the accelerated expansion of the universe, different observational probes have been proposed to investigate the presence of dark energy, including possible modifications to the gravitation laws by accurately measuring the expansion of the Universe and the growth of structures. We need to optimize the return from future dark energy surveys to obtain the best results from these probes. Aims: A high precision weak-lensing analysis requires not an only accurate measurement of galaxy shapes but also a precise and unbiased measurement of galaxy redshifts. The survey strategy has to be defined following both the photometric redshift and shape measurement accuracy. Methods: We define the key properties of the weak-lensing instrument and compute the effective PSF and the overall throughput and sensitivities. We then investigate the impact of the pixel scale on the sampling of the effective PSF, and place upper limits on the pixel scale. We then define the survey strategy computing the survey area including in particular both the Galactic absorption and Zodiacal light variation accross the sky. Using the Le Phare photometric redshift code and realistic galaxy mock catalog, we investigate the properties of different filter-sets and the importance of the u-band photometry quality to optimize the photometric redshift and the dark energy figure of merit (FoM). Results: Using the predicted photometric redshift quality, simple shape measurement requirements, and a proper sky model, we explore what could be an optimal weak-lensing dark energy mission based on FoM calculation. We find that we can derive the most accurate the photometric redshifts for the bulk of the faint galaxy population when filters have a resolution ℛ ~ 3.2. We show that an optimal mission would survey the sky through eight filters using two cameras (visible and near infrared). Assuming a five-year mission duration, a mirror size of 1.5 m and a 0.5 deg2 FOV with a visible pixel

Statistics of gravitational lenses - The uncertainties

NASA Technical Reports Server (NTRS)

Mao, Shude

1991-01-01

The assumptions in the analysis of gravitational lensing statistics are examined. Special emphasis is given to the uncertainties in the theoretical predictions. It is shown that a simple redshift cutoff model, which may result from galaxy evolution, can significantly reduce the lensing probability and explain the large mean separation of images in observed gravitational lenses. This effect may affect the constraint on the contribution of the cosmological constant to producing a flat universe from the number counts of the observed lenses. For the Omega(0) = 1 (filled beam) model, the lensing probability of early-type galaxies with finite core radii is reduced roughly by a factor of 2 for high-redshift quasars as compared with the corresponding singular isothermal sphere model. The finite core radius effect is about 20 percent for a lambda-dominated flat universe. It is also shown that the most recent galaxy luminosity function gives lensing probabilities that are smaller than previously estimated roughly by a factor of 3.

On weak lensing shape noise

NASA Astrophysics Data System (ADS)

Niemi, Sami-Matias; Kitching, Thomas D.; Cropper, Mark

2015-12-01

One of the most powerful techniques to study the dark sector of the Universe is weak gravitational lensing. In practice, to infer the reduced shear, weak lensing measures galaxy shapes, which are the consequence of both the intrinsic ellipticity of the sources and of the integrated gravitational lensing effect along the line of sight. Hence, a very large number of galaxies is required in order to average over their individual properties and to isolate the weak lensing cosmic shear signal. If this `shape noise' can be reduced, significant advances in the power of a weak lensing surveys can be expected. This paper describes a general method for extracting the probability distributions of parameters from catalogues of data using Voronoi cells, which has several applications, and has synergies with Bayesian hierarchical modelling approaches. This allows us to construct a probability distribution for the variance of the intrinsic ellipticity as a function of galaxy property using only photometric data, allowing a reduction of shape noise. As a proof of concept the method is applied to the CFHTLenS survey data. We use this approach to investigate trends of galaxy properties in the data and apply this to the case of weak lensing power spectra.

Glasses and Contact Lenses

MedlinePlus

... vision problems; this includes prescribing eyeglasses and contact lenses, but also doing eye surgery for other eye-related problems. An optometrist ... them clean. The most important thing about contact lenses is good hygiene to prevent infections in your eye. But the really fun part of new glasses ...

Strong Lensing Mass Reconstruction: from Frontier Fields to the Typical Lensing Clusters of Future Surveys

NASA Astrophysics Data System (ADS)

Sharon, Keren; Gladders, Michael D.; Rigby, Jane R.; Bayliss, Matthew B.; Wuyts, Eva; Dahle, Håkon; Johnson, Traci L.; Florian, Michael K.; Dunham, Samuel; Murray, Katherine; Whitaker, Kate; Li, Nan

Driven by the unprecedented wealth of high quality data that is accumulating for the Frontier Fields, they are becoming some of the best-studied strong lensing clusters to date, and probably the next few years. As will be discussed intensively in this focus meeting, the FF prove transformative for many fields: from studies of the high redshift Universe, to the assembly and structure of the clusters themselves. The FF data and the extensive collaborative effort around this program will also allow us to examine and improve upon current lens modeling techniques. Strong lensing is a powerful tool for mass reconstruction of the cores of galaxy clusters of all scales, providing an estimate of the total (dark and seen) projected mass density distribution out to 0.5 Mpc. Though SL mass may be biased by contribution from structures along the line of sight, its strength is that it is relatively insensitive to assumptions on cluster baryon astrophysics and dynamical state. Like the Frontier Fields clusters, the most ``famous'' strong lensing clusters are at the high mass end; they lens dozens of background sources into multiple images, providing ample lensing constraints. In this talk, I will focus on how we can leverage what we learn from modeling the FF clusters in strong lensing studies of the hundreds of clusters that will be discovered in upcoming surveys. In typical clusters, unlike the Frontier Fields, the Bullet Cluster and A1689, we observe only one to a handful of background sources, and have limited lensing constraints. I will describe the limitations that such a configuration imposes on strong lens modeling, highlight measurements that are robust to the richness of lensing evidence, and address the sources of uncertainty and what sort of information can help reduce those uncertainties. This category of lensing clusters is most relevant to the wide cluster surveys of the future.

Strong Lensing Mass Reconstruction: from Frontier Fields to the Typical Lensing Clusters of Future Surveys

NASA Astrophysics Data System (ADS)

Sharon, Keren

2015-08-01

Driven by the unprecedented wealth of high quality data that is accumulating for the Frontier Fields, they are becoming some of the best-studied strong lensing clusters to date, and probably the next few years. As will be discussed intensively in this focus meeting, the FF prove transformative for many fields: from studies of the high redshift Universe, to the assembly and structure of the clusters themselves. The FF data and the extensive collaborative effort around this program will also allow us to examine and improve upon current lens modeling techniques. Strong lensing is a powerful tool for mass reconstruction of the cores of galaxy clusters of all scales, providing an estimate of the total (dark and seen) projected mass density distribution out to ~0.5 Mpc. Though SL mass may be biased by contribution from structures along the line of sight, its strength is that it is relatively insensitive to assumptions on cluster baryon astrophysics and dynamical state. Like the Frontier Fields clusters, the most "famous" strong lensing clusters are at the high mass end; they lens dozens of background sources into multiple images, providing ample lensing constraints. In this talk, I will focus on how we can leverage what we learn from modeling the FF clusters in strong lensing studies of the hundreds of clusters that will be discovered in upcoming surveys. In typical clusters, unlike the Frontier Fields, the Bullet Cluster and A1689, we observe only one to a handful of background sources, and have limited lensing constraints. I will describe the limitations that such a configuration imposes on strong lens modeling, highlight measurements that are robust to the richness of lensing evidence, and address the sources of uncertainty and what sort of information can help reduce those uncertainties. This category of lensing clusters is most relevant to the wide cluster surveys of the future.

RELICS: Reionization Lensing Cluster Survey - Discovering Brightly Lensed Distant Galaxies for JWST

NASA Astrophysics Data System (ADS)

Coe, Dan; Bradley, Larry; Salmon, Brett; Avila, Roberto J.; Ogaz, Sara; Bradac, Marusa; Huang, Kuang-Han; Strait, Victoria; Hoag, Austin; Sharon, Keren q.; Cerny, Catherine; Paterno-Mahler, Rachel; Johnson, Traci Lin; Mahler, Guillaume; Zitrin, Adi; Sendra Server, Irene; Acebron, Ana; Cibirka, Nathália; Rodney, Steven; Strolger, Louis; Riess, Adam; Dawson, William; Jones, Christine; Andrade-Santos, Felipe; Lovisari, Lorenzo; Czakon, Nicole; Umetsu, Keiichi; Trenti, Michele; Vulcani, Benedetta; Carrasco, Daniela; Livermore, Rachael; Stark, Daniel P.; Mainali, Ramesh; Frye, Brenda; Oesch, Pascal; Lam, Daniel; Toft, Sune; Ryan, Russell; Peterson, Avery; Past, Matthew; Kikuchihara, Shotaro; Ouchi, Masami; Oguri, Masamune

2018-01-01

The Reionization Lensing Cluster Survey (RELICS) Hubble Treasury Program has completed observations of 41 massive galaxy clusters with 188 orbits of HST ACS and WFC3/IR imaging and 390 hours of Spitzer IRAC imaging. This poster presents an overview of the program and data releases. Reduced images, catalogs, and lens models for all clusters are now available on MAST. RELICS is studying the clusters, supernovae, and lensed high-redshift galaxies. A companion poster presents our high-redshift results: over 300 lensed z ~ 6 - 10 candidates, including some of the brightest known at these redshifts (Salmon et al. 2018). These will be excellent targets for detailed follow-up study in JWST Cycle 1 GO proposals.

The shortest Th-Th distance from a new type of quadruple bond.

PubMed

Hu, Han-Shi; Kaltsoyannis, Nikolas

2017-02-15

Compounds featuring unsupported metal-metal bonds between actinide elements remain highly sought after yet confined experimentally to inert gas matrix studies. Notwithstanding this paucity, actinide-actinide bonding has been the subject of extensive computational research. In this contribution, high level quantum chemical calculations at both the scalar and spin-orbit levels are used to probe the Th-Th bonding in a range of zero valent systems of general formula LThThL. Several of these compounds have very short Th-Th bonds arising from a new type of Th-Th quadruple bond with a previously unreported electronic configuration featuring two unpaired electrons in 6d-based δ bonding orbitals. H 3 AsThThAsH 3 is found to have the shortest Th-Th bond yet reported (2.590 Å). The Th 2 unit is a highly sensitive probe of ligand electron donor/acceptor ability; we can tune the Th-Th bond from quadruple to triple, double and single by judicious choice of the L group, up to 2.888 Å for singly-bonded ONThThNO.

Thermal lensing in ocular media

NASA Astrophysics Data System (ADS)

Vincelette, Rebecca Lee

2009-12-01

This research was a collaborative effort between the Air Force Research Laboratory (AFRL) and the University of Texas to examine the laser-tissue interaction of thermal lensing induced by continuous-wave, CW, near-infrared, NIR, laser radiation in the eye and its influence on the formation of a retinal lesion from said radiation. CW NIR laser radiation can lead to a thermal lesion induced on the retina given sufficient power and exposure duration as related to three basic parameters; the percent of transmitted energy to, the optical absorption of, and the size of the laser-beam created at the retina. Thermal lensing is a well-known phenomenon arising from the optical absorption, and subsequent temperature rise, along the path of the propagating beam through a medium. Thermal lensing causes the laser-beam profile delivered to the retina to be time dependent. Analysis of a dual-beam, multidimensional, high-frame rate, confocal imaging system in an artificial eye determined the rate of thermal lensing in aqueous media exposed to 1110, 1130, 1150 and 1318-nm wavelengths was related to the power density created along the optical axis and linear absorption coefficient of the medium. An adaptive optics imaging system was used to record the aberrations induced by the thermal lens at the retina in an artificial eye during steady-state. Though the laser-beam profiles changed over the exposure time, the CW NIR retinal damage thresholds between 1110--1319-nm were determined to follow conventional fitting algorithms which neglected thermal lensing. A first-order mathematical model of thermal lensing was developed by conjoining an ABCD beam propagation method, Beer's law of attenuation, and a solution to the heat-equation with respect to radial diffusion. The model predicted that thermal lensing would be strongest for small (< 4-mm) 1/e2 laser-beam diameters input at the corneal plane and weakly transmitted wavelengths where less than 5% of the energy is delivered to the retina

Quadruple-first line drug resistance in Mycobacterium tuberculosis in Vietnam: What can we learn from genes?

PubMed

Nguyen, Huy Quang; Nguyen, Nhung Viet; Contamin, Lucie; Tran, Thanh Hoa Thi; Vu, Thuong Thi; Nguyen, Hung Van; Nguyen, Ngoc Lan Thi; Nguyen, Son Thai; Dang, Anh Duc; Bañuls, Anne-Laure; Nguyen, Van Anh Thi

2017-06-01

In Vietnam, a country with high tuberculosis (137/100.000 population) and multidrug-resistant (MDR)-TB burdens (7.8/100.000 population), little is known about the molecular signatures of drug resistance in general and more particularly of second line drug (SLD) resistance. This study is specifically focused on Mycobacterium tuberculosis isolates resistant to four first-line drugs (FLDs) that make TB much more difficult to treat. The aim is to determine the proportion of SLD resistance in these quadruple drug resistant isolates and the genetic determinants linked to drug resistance to better understand the genetic processes leading to quadruple and extremely drug resistance (XDR). 91 quadruple (rifampicin, isoniazid, ethambutol and streptomycin) FLD resistant and 55 susceptible isolates were included. Spoligotyping and 24-locus MIRU-VNTR techniques were performed and 9 genes and promoters linked to FLD and SLD resistance were sequenced. SLD susceptibility testing was carried out on a subsample of isolates. High proportion of quadruple-FLD resistant isolates was resistant to fluoroquinolones (27%) and second-line injectable drugs (30.2%) by drug susceptibility testing. The sequencing revealed high mutation diversity with prevailing mutations at positions katG315, inhA-15, rpoB531, embB306, rrs1401, rpsL43 and gyrA94. The sensitivity and specificity were high for most drug resistances (>86%), but the sensitivity was lower for injectable drug resistances (<69%). The mutation patterns revealed 23.1% of pre-XDR and 7.7% of XDR isolates, mostly belonging to Beijing family. The genotypic diversity and the variety of mutations reflect the existence of various evolutionary paths leading to FLD and SLD resistance. Nevertheless, particular mutation patterns linked to high-level resistance and low fitness costs seem to be favored. Copyright © 2017 Elsevier B.V. All rights reserved.

Strong Gravitational Lensing: Relativity in Action

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

2009-05-01

Deflection of light by gravity was predicted by Einstein's Theory of General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically, among them measuring the Hubble constant from multiple images of a background source, making use of the magnifying effect as a gravitational telescope, or the possibility of a "relativistic eclipse" as a perfect test of GR. Only in 1979, gravitational lensing became an observational science when the first doubly imaged quasar was discovered. Today lensing is a booming part of astrophysics and cosmology. A whole suite of strong lensing phenomena have been investigated since: multiple quasars, giant luminous arcs, Einstein rings, quasar microlensing, and galactic microlensing. The most recent lensing application is the detection of extrasolar planets. Lensing has contributed significant new results in areas as different as the cosmological distance scale, mass determination of galaxy clusters, physics of quasars, searches for dark matter in galaxy halos, structure of the Milky Way, stellar atmospheres and exoplanets. A guided tour through some of these applications -- with both photometric and astrometric signatures of lensing being discussed -- will illustrate how gravitational lensing has established itself as a very useful universal astrophysical tool.

Self-aligned quadruple patterning-compliant placement

NASA Astrophysics Data System (ADS)

Nakajima, Fumiharu; Kodama, Chikaaki; Nakayama, Koichi; Nojima, Shigeki; Kotani, Toshiya

2015-03-01

Self-Aligned Quadruple Patterning (SAQP) will be one of the leading candidates for sub-14nm node and beyond. However, compared with triple patterning, making a feasible standard cell placement has following problems. (1) When coloring conflicts occur between two adjoining cells, they may not be solved easily since SAQP layout has stronger coloring constraints. (2) SAQP layout cannot use stitch to solve coloring conflict. In this paper, we present a framework of SAQP-aware standard cell placement considering the above problems. When standard cell is placed, the proposed method tries to solve coloring conflicts between two cells by exchanging two of three colors. If some conflicts remain between adjoining cells, dummy space will be inserted to keep coloring constraints of SAQP. We show some examples to confirm effectiveness of the proposed framework. To our best knowledge, this is the first framework of SAQP-aware standard cell placement.

Gravitational lensing in quasar samples

NASA Astrophysics Data System (ADS)

Claeskens, Jean-François; Surdej, Jean

The first cosmic mirage was discovered approximately 20 years ago as the double optical counterpart of a radio source. This phenomenon had been predicted some 70 years earlier as a consequence of General Relativity. We present here a summary of what we have learnt since. The applications are so numerous that we had to concentrate on a few selected aspects of this new field of research. This review is focused on strong gravitational lensing, i.e. the formation of multiple images, in QSO samples. It is intended to give the reader an up-to-date status of the observations and to present an overview of its most interesting potential applications in cosmology and astrophysics, as well as numerous important results achieved so far. The first section follows an intuitive approach to the basics of gravitational lensing and is developed in view of our interest in multiply imaged quasars. The astrophysical and cosmological applications of gravitational lensing are outlined in Sect. 2 and the most important results are presented in Sect. 5. Sections 3 and 4 are devoted to the observations. Finally, conclusions are summarized in the last section. We have tried to avoid duplication with existing (and excellent) introductions to the field of gravitational lensing. For this reason, we did not concentrate on the individual properties of specific lens models, as these are already well presented in Narayan and Bartelmann (1996) and on a more intuitive ground in Refsdal and Surdej (1994). Wambsganss (1998) proposes a broad view on gravitational lensing in astronomy; the reviews by Fort and Mellier (1994) and Hattori et al. (1999) deal with lensing by galaxy clusters; microlensing in the Galaxy and the local group is reviewed by Paczynski (1996) and a general panorama on weak lensing is given by Bartelmann and Schneider (1999) and Mellier (1999). The monograph on the theory of gravitational lensing by Schneider, Ehlers and Falco (1992) also remains a reference in the field.

Microbial adhesion to silicone hydrogel lenses: a review.

PubMed

Willcox, Mark D P

2013-01-01

Microbial adhesion to contact lenses is believed to be one of the initiating events in the formation of many corneal infiltrative events, including microbial keratitis, that occur during contact lens wear. The advent of silicone hydrogel lenses has not reduced the incidence of these events. This may partly be related to the ability of microbes to adhere to these lenses. The aim of this study was to review the published literature on microbial adhesion to contact lenses, focusing on adhesion to silicone hydrogel lenses. The literature on microbial adhesion to contact lenses was searched, along with associated literature on adverse events that occur during contact lens wear. Particular reference was paid to the years 1995 through 2012 because this encompasses the time when the first clinical trials of silicone hydrogel lenses were reported, and their commercial availability and the publication of epidemiology studies on adverse events were studied. In vitro studies of bacterial adhesion to unworn silicone hydrogel lens have shown that generally, bacteria adhere to these lenses in greater numbers than to the hydroxyethyl methacrylate-based soft lenses. Lens wear has different effects on microbial adhesion, and this is dependent on the type of lens and microbial species/genera that is studied. Biofilms that can be formed on any lens type tend to protect the bacteria and fungi from the effects on disinfectants. Fungal hyphae can penetrate the surface of most types of lenses. Acanthamoeba adhere in greater numbers to first-generation silicone hydrogel lenses compared with the second-generation or hydroxyethyl methacrylate-based soft lenses. Microbial adhesion to silicone hydrogel lenses occurs and is associated with the production of corneal infiltrative events during lens wear.

Ultrafast Exciton Delocalization, Localization, and Excimer Formation Dynamics in a Highly Defined Perylene Bisimide Quadruple π-Stack.

PubMed

Kaufmann, Christina; Kim, Woojae; Nowak-Król, Agnieszka; Hong, Yongseok; Kim, Dongho; Würthner, Frank

2018-03-28

An adequately designed, bay-tethered perylene bisimide (PBI) dimer Bis-PBI was synthesized by Pd/Cu-catalyzed Glaser-type oxidative homocoupling of the respective PBI building block. This newly synthesized PBI dimer self-assembles exclusively and with high binding constants of up to 10 6 M -1 into a discrete π-stack of four chromophores. Steady-state absorption and emission spectra show the signatures of H-type excitonic coupling among the dye units. Broadband fluorescence upconversion spectroscopy (FLUPS) reveals an ultrafast dynamics in the optically excited state. An initially coherent Frenkel exciton state that is delocalized over the whole quadruple stack rapidly (τ = ∼200 fs) loses its coherence and relaxes into an excimer state. Comparison with Frenkel exciton dynamics in PBI dimeric and oligomeric H-aggregates demonstrates that in the quadruple stack coherent exciton propagation is absent due to its short length of aggregates, thereby it has only one relaxation pathway to the excimer state. Furthermore, the absence of pump-power dependence in transient absorption experiments suggests that multiexciton cannot be generated in the quadruple stack, which is in line with time-resolved fluorescence measurements.

Strong Gravitational Lensing with LSST

NASA Astrophysics Data System (ADS)

Marshall, Philip J.; Bradac, M.; Chartas, G.; Dobler, G.; Eliasdottir, A.; Falco, E.; Fassnacht, C. D.; Jee, M. J.; Keeton, C. R.; Oguri, M.; Tyson, J. A.; LSST Strong Lensing Science Collaboration

2010-01-01

LSST will find more strong gravitational lensing events than any other survey preceding it, and will monitor them all at a cadence of a few days to a few weeks. We can expect the biggest advances in strong lensing science made with LSST to be in those areas that benefit most from the large volume, and the high accuracy multi-filter time series: studies of, and using, several thousand lensed quasars and several hundred supernovae. However, the high quality imaging will allow us to detect and measure large numbers of background galaxies multiply-imaged by galaxies, groups and clusters. In this poster we give an overview of the strong lensing science enabled by LSST, and highlight the particular associated technical challenges that will have to be faced when working with the survey.

Adhesion of Pseudomonas aeruginosa to orthokeratology and alignment lenses.

PubMed

Choo, Jennifer D; Holden, Brien A; Papas, Eric B; Willcox, Mark D P

2009-02-01

To determine whether contact lenses designed for orthokeratology (OK) are colonized by greater numbers of bacteria compared with standard (alignment fitted) design rigid gas permeable lenses before and after lens wear. Eighteen 1-year-old cats were randomly fitted with an OK lens in one eye and an alignment fitted (AF) lens in the other eye. Both lenses were made in the same diameter and central thickness and of the same material. Two separate wearing periods of 2 weeks and 6 weeks were used. After each wearing period, lenses were soaked in Pseudomonas aeruginosa (6294 or 6206) for 10 min. The lenses were then reinserted onto their respective corneas for a wearing period of 16 hours after which lenses were collected and remaining adhered bacteria quantified. Unworn control lenses were also soaked and bacteria enumerated for comparison. There were no significant differences in the number of bacteria adherent to unworn AF and OK lenses. Analysis of lenses after wear showed OK lenses retained significantly higher numbers of viable bacteria than AF lenses in all studies. OK lenses retain more bacteria than AF rigid gas permeable lenses after bacteria-loaded overnight lens wear. This may increase the risk for an infection in OK patients should suitable conditions be present. Specific education on the cleaning of OK lenses is essential.

TRICARE Policy and Operations: Evolving to Support the Quadruple Aim

DTIC Science & Technology

2011-01-24

Examples of Evolution – TRICARE in Alaska – Autism Services Demonstration 2011 MHS Conference 3 Track L  Evolving to achieve the Quadruple Aim...Heidelberg MEDDAC Lessons Learned 1, 2, 3, 4 1, 2, 3, 4 2 a. TRICARE in Alaska b. Autism Services Demonstration c. A Regional View 3 1 1, 2...3, 4 3 TRICARE Pharmacy Programs 3, 4 4 TRICARE for Reserves and National Guard 1, 2, 3 5 TRICARE Dental Programs 1, 2, 4 6 a

One Episode, Two Lenses

ERIC Educational Resources Information Center

Drijvers, Paul; Godino, Juan D.; Font, Vicenc; Trouche, Luc

2013-01-01

A deep understanding of students' learning processes is one of the core challenges of research in mathematics education. To achieve this, different theoretical lenses are available. The question is how these different lenses compare and contrast, and how they can be coordinated and combined to provide a more comprehensive view on the topic of…

Contact Lenses in the Laboratory.

ERIC Educational Resources Information Center

Kingston, David W.

1981-01-01

Summarizes results of a three-item questionnaire returned by 43 Michigan institutions expressing views on wearing contact lenses in chemical laboratories. Questions focused on eye protection, type of protection, and use of contact lenses. (SK)

Gravitational lensing and the Lyman-alpha forest

NASA Technical Reports Server (NTRS)

Ikeuchi, Satoru; Turner, Edwin L.

1991-01-01

Possible connections between the inhomogeneities responsible for the Lyman-alpha forest in quasar spectra and gravitational lensing effects are investigated. For most models of the Lyman-alpha forest, no significant lensing is expected. For some versions of the CDM model-based minihalo hypothesis, gravitational lensings on scales less than abour 0.1 arcsec would occur with a frequency approaching that with which ordinary galaxies cause arcsecond scale lensing.

Lensing duct

DOEpatents

Beach, R.J.; Benett, W.J.

1994-04-26

A lensing duct to condense (intensify) light using a combination of front surface lensing and reflective waveguiding is described. The duct tapers down from a wide input side to a narrow output side, with the input side being lens-shaped and coated with an antireflective coating for more efficient transmission into the duct. The four side surfaces are uncoated, preventing light from escaping by total internal reflection as it travels along the duct (reflective waveguiding). The duct has various applications for intensifying light, such as in the coupling of diode array pump light to solid state lasing materials, and can be fabricated from inexpensive glass and plastic. 3 figures.

Survey of Gravitationally-lensed Objects in HSC Imaging (SuGOHI). I. Automatic search for galaxy-scale strong lenses

NASA Astrophysics Data System (ADS)

Sonnenfeld, Alessandro; Chan, James H. H.; Shu, Yiping; More, Anupreeta; Oguri, Masamune; Suyu, Sherry H.; Wong, Kenneth C.; Lee, Chien-Hsiu; Coupon, Jean; Yonehara, Atsunori; Bolton, Adam S.; Jaelani, Anton T.; Tanaka, Masayuki; Miyazaki, Satoshi; Komiyama, Yutaka

2018-01-01

The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is an excellent survey for the search for strong lenses, thanks to its area, image quality, and depth. We use three different methods to look for lenses among 43000 luminous red galaxies from the Baryon Oscillation Spectroscopic Survey (BOSS) sample with photometry from the S16A internal data release of the HSC-SSP. The first method is a newly developed algorithm, named YATTALENS, which looks for arc-like features around massive galaxies and then estimates the likelihood of an object being a lens by performing a lens model fit. The second method, CHITAH, is a modeling-based algorithm originally developed to look for lensed quasars. The third method makes use of spectroscopic data to look for emission lines from objects at a different redshift from that of the main galaxy. We find 15 definite lenses, 36 highly probable lenses, and 282 possible lenses. Among the three methods, YATTALENS, which was developed specifically for this study, performs best in terms of both completeness and purity. Nevertheless, five highly probable lenses were missed by YATTALENS but found by the other two methods, indicating that the three methods are highly complementary. Based on these numbers, we expect to find ˜300 definite or probable lenses by the end of the HSC-SSP.

Breaking the imaging symmetry in negative refraction lenses.

PubMed

Ma, Changbao; Liu, Zhaowei

2012-01-30

Optical lenses are pervasive in various areas of sciences and technologies. It is well known that conventional lenses have symmetrical imaging properties along forward and backward directions. In this letter, we show that hyperbolic plasmonic metamaterial based negative refraction lenses perform as either converging lenses or diverging lenses depending on the illumination directions. New imaging equations and properties that are different from those of all the existing optical lenses are also presented. These new imaging properties, including symmetry breaking as well as the super resolving power, significantly expand the horizon of imaging optics and optical system design.

The Quadruple-lined, Doubly Eclipsing System V482 Persei

NASA Astrophysics Data System (ADS)

Torres, Guillermo; Sandberg Lacy, Claud H.; Fekel, Francis C.; Wolf, Marek; Muterspaugh, Matthew W.

2017-09-01

We report spectroscopic and differential photometric observations of the A-type system V482 Per, which reveal it to be a rare hierarchical quadruple system containing two eclipsing binaries. One binary has the previously known orbital period of 2.4 days and a circular orbit, and the other a period of 6 days, a slightly eccentric orbit (e = 0.11), and shallow eclipses only 2.3% deep. The two binaries revolve around their common center of mass in a highly elongated orbit (e = 0.85) with a period of 16.67 yr. Radial velocities are measured for all components from our quadruple-lined spectra and are combined with the light curves and measurements of times of minimum light for the 2.4 day binary to solve for the elements of the inner and outer orbits simultaneously. The line-of-sight inclination angles of the three orbits are similar, suggesting they may be close to coplanar. The available observations appear to indicate that the 6 day binary experiences significant retrograde apsidal motion in the amount of about 60 deg per century. We derive absolute masses for the four stars good to better than 1.5%, along with radii with formal errors of 1.1% and 3.5% for the 2.4 day binary and ˜9% for the 6 day binary. A comparison of these and other physical properties with current stellar evolution models gives excellent agreement for a metallicity of [{Fe}/{{H}}]=-0.15 and an age of 360 Myr.

Solutions for care of silicone hydrogel lenses.

PubMed

Willcox, Mark D P

2013-01-01

During wear of contact lenses on a daily wear basis, it is necessary to disinfect the lens overnight before reinserting the lens the next day. The ability of the solutions used for this to disinfect lenses and lens cases is important for safe lens wear. The literature on the disinfecting ability of multipurpose disinfecting solutions (MPDS) commonly used with silicone hydrogel lenses reported during the period 2000 to 2012 is reviewed, as this is the period of time during which these lenses have been commercially available. Particular emphasis is placed on the ability of disinfecting solutions to control colonization of lens cases by microbes and changes in composition and use of the solutions. In addition, the literature is reviewed on ways of minimizing lens case microbial contamination. Maintaining the hygiene of contact lenses and lens cases is important in minimizing various forms of corneal infiltrative events that occur during lens wear. Although lens case contamination is not associated with different lenses, it is determined by use of different MPDS. MPDS that allow more frequent or heavy contamination of cases by Gram-negative bacteria are associated with a higher incidence of corneal infiltrative events. MPDS are now available that contain dual disinfectants. Wiping lens cases with tissues or using lens cases that incorporate silver are associated with reductions in contamination in clinical trials. Similarly, using MPDS to rub and rinse lenses before disinfection may reduce levels of microbes on lenses. The MPDS also contain surfactants that help reduce deposition and denaturation of proteins on lenses. Improvements in MPDS formulations and hygiene practices may help to reduce the incidence of adverse events that are seen during use with silicone hydrogel lenses.

Weak lensing of the Lyman α forest

NASA Astrophysics Data System (ADS)

Croft, Rupert A. C.; Romeo, Alessandro; Metcalf, R. Benton

2018-06-01

The angular positions of quasars are deflected by the gravitational lensing effect of foreground matter. The Lyman α (Lyα) forest seen in the spectra of these quasars is therefore also lensed. We propose that the signature of weak gravitational lensing of the Lyα forest could be measured using similar techniques that have been applied to the lensed cosmic microwave background (CMB), and which have also been proposed for application to spectral data from 21-cm radio telescopes. As with 21-cm data, the forest has the advantage of spectral information, potentially yielding many lensed `slices' at different redshifts. We perform an illustrative idealized test, generating a high-resolution angular grid of quasars (of order arcminute separation), and lensing the Lyα forest spectra at redshifts z = 2-3 using a foreground density field. We find that standard quadratic estimators can be used to reconstruct images of the foreground mass distribution at z ˜ 1. There currently exists a wealth of Lyα forest data from quasar and galaxy spectral surveys, with smaller sightline separations expected in the future. Lyα forest lensing is sensitive to the foreground mass distribution at redshifts intermediate between CMB lensing and galaxy shear, and avoids the difficulties of shape measurement associated with the latter. With further refinement and application of mass reconstruction techniques, weak gravitational lensing of the high-redshift Lyα forest may become a useful new cosmological probe.

Galaxy–Galaxy Weak-lensing Measurements from SDSS. I. Image Processing and Lensing Signals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Wentao; Yang, Xiaohu; Zhang, Jun

We present our image processing pipeline that corrects the systematics introduced by the point-spread function (PSF). Using this pipeline, we processed Sloan Digital Sky Survey (SDSS) DR7 imaging data in r band and generated a galaxy catalog containing the shape information. Based on our shape measurements of the galaxy images from SDSS DR7, we extract the galaxy–galaxy (GG) lensing signals around foreground spectroscopic galaxies binned in different luminosities and stellar masses. We estimated the systematics, e.g., selection bias, PSF reconstruction bias, PSF dilution bias, shear responsivity bias, and noise rectification bias, which in total is between −9.1% and 20.8% atmore » 2 σ levels. The overall GG lensing signals we measured are in good agreement with Mandelbaum et al. The reduced χ {sup 2} between the two measurements in different luminosity bins are from 0.43 to 0.83. Larger reduced χ {sup 2} from 0.60 to 1.87 are seen for different stellar mass bins, which is mainly caused by the different stellar mass estimator. The results in this paper with higher signal-to-noise ratio are due to the larger survey area than SDSS DR4, confirming that more luminous/massive galaxies bear stronger GG lensing signals. We divide the foreground galaxies into red/blue and star-forming/quenched subsamples and measure their GG lensing signals. We find that, at a specific stellar mass/luminosity, the red/quenched galaxies have stronger GG lensing signals than their counterparts, especially at large radii. These GG lensing signals can be used to probe the galaxy–halo mass relations and their environmental dependences in the halo occupation or conditional luminosity function framework.« less

Microbial adherence to cosmetic contact lenses.

PubMed

Chan, Ka Yin; Cho, Pauline; Boost, Maureen

2014-08-01

To investigate whether cosmetic contact lenses (CCL) with surface pigments affect microbial adherence. Fifteen brands of CCL were purchased from optical, non-optical retail outlets, and via the Internet. A standardized rub-off test was performed on each CCL (five lenses per brand) to confirm the location of the pigments. The rub-off test comprised gentle rubbing on the surfaces of each CCL with wetted cotton buds for a maximum of 20 rubs per surface. A new set of CCL (five lenses per brand) were incubated in Pseudomonas aeruginosa overnight. Viable counts of adhered bacteria were determined by the number of colony-forming units (CFU) on agar media on each lens. The adherence of P. aeruginosa as well as Staphylococcus aureus and Serratia marcescens to three brands of CCL (A-C) (five lenses per brand) were also compared to their adherences on their clear counterparts. Only two of the 15 brands of CCL tested (brands B and C) had pigments that did not detach with the rub-off test. The remaining 13 brands of CCL all failed the rub-off test and these lenses showed higher P. aeruginosa adherence (8.7 × 10(5)-1.9 × 10(6) CFU/lens). Brands B and C lenses showed at least six times less bacterial adhesion than the other 13 brands. Compared to their clear counterparts, bacterial adherence to brands B and C lenses did not differ significantly, whereas brand A lenses showed significantly higher adherence. Surface pigments on CCL resulted in significantly higher bacterial adherence. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Strong gravitational lensing: relativity in action

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

2010-01-01

Deflection of light by gravity was predicted by Einstein's Theory of General Relativity and observationally confirmed in 1919. In the following decades, various aspects of the gravitational lens effect were explored theoretically, among them measuring the Hubble constant from multiple images of a background source, making use of the magnifying effect as a gravitational telescope, or the possibility of a “relativistic eclipse” as a perfect test of GR. Only in 1979, gravitational lensing became an observational science when the first doubly imaged quasar was discovered. Today lensing is a booming part of astrophysics and cosmology. A whole suite of strong lensing phenomena have been investigated: multiple quasars, giant luminous arcs, Einstein rings, quasar microlensing, and galactic microlensing. The most recent lensing application is the detection of extrasolar planets. Lensing has contributed significant new results in areas as different as the cosmological distance scale, mass determination of galaxy clusters, physics of quasars, searches for dark matter in galaxy halos, structure of the Milky Way, stellar atmospheres and exoplanets. A guided tour through some of these applications will illustrate how gravitational lensing has established itself as a very useful universal astrophysical tool.

Recommended coordinate systems for thin spherocylindrical lenses.

PubMed

Deal, F C; Toop, J

1993-05-01

Because the set of thin spherocylindrical lenses forms a vector space, any such lens can be expressed in terms of its cartesian coordinates with respect to whatever set of basis lenses we may choose. Two types of cartesian coordinate systems have become prominent, those having coordinates associated with the lens power matrix and those having coordinates associated with the Humphrey Vision Analyzer. This paper emphasizes the value of a particular cartesian coordinate system of the latter type, and the cylindrical coordinate system related to it, by showing how it can simplify the trigonometry of adding lenses and how it preserves symmetry in depicting the sets of all spherical lenses, all Jackson crossed-cylinders, and all cylindrical lenses. It also discusses appropriate coordinates for keeping statistics on lenses and shows that an easy extension of the lens vector space to include general optical systems is not possible.

Gravitational Lensing

ScienceCinema

Lincoln, Don

2018-01-16

In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

Gravitational Lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter ofmore » the entire universe, including the otherwise-invisible dark matter.« less

Spatially resolved spectroscopy of lensed galaxies in the Frontier Fields

NASA Astrophysics Data System (ADS)

Jones, Tucker; Aff004

The Grism Lens-Amplified Survey from Space (GLASS) has obtained slitless near-infrared spectroscopy of 10 galaxy clusters selected for their strong lensing properties, including all six Hubble Frontier Fields. Slitless grism spectra are ideal for mapping emission lines such as [O ii], [O iii], and Hα at z=1-3. The combination of strong gravitational lensing and Hubble's diffraction limit provides excellent sensitivity with spatial resolution as fine as 100 pc for highly magnified sources, and ~500 pc for less magnified sources near the edge of the field of view. The GLASS survey represents the largest spectroscopic sample with such high resolution at z > 1. GLASS and Hubble Frontier Field data provide the distribution of stellar mass, star formation, gas-phase metallicity, and other aspects of the physical structure of high redshift galaxies, reaching stellar masses as low as ~107 M⊙ at z=2. I discuss precise measurements of these physical properties and implications for galaxy evolution.

Biocompatibility of antimicrobial melimine lenses: rabbit and human studies.

PubMed

Dutta, Debarun; Ozkan, Jerome; Willcox, Mark D P

2014-05-01

Covalent immobilization of antimicrobial peptide melimine onto contact lenses can produce broad-spectrum antimicrobial lenses. The purpose of this study was to investigate the performance of melimine-coated contact lenses in an animal model and human clinical trial. Melimine was covalently attached onto the surface of contact lenses via EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride) coupling. A rabbit model of daily contralateral wear of lenses for 22 days was conducted to assess the lens safety. A prospective, randomized, double-masked, one-day human clinical trial was used to evaluate subjective responses and ocular physiology during contralateral wear of melimine-coated (test) and uncoated (control) lenses. Delayed reactions were monitored during follow-up visits after 1 and 4 weeks. Ex vivo retention of antimicrobial activity of worn lenses was assessed by reduction in numbers of viable Pseudomonas aeruginosa and Staphylococcus aureus. Melimine-coated lenses produced no ocular signs or symptoms that would indicate cytotoxicity during the lens wear of rabbits. No histological changes were found in rabbit corneas. During the human trial, no differences were observed in wettability, surface deposition, lens-fitting centration, movement, tightness, and corneal coverage between test and control lenses (p > 0.05). There were no significant differences in bulbar, limbal, or palpebral redness or conjunctival staining (p > 0.05). Mean corneal (extent, depth, and type) staining was higher for test lenses compared with that for control lenses (p < 0.05). There was no significant difference in subjective responses for lens comfort, dryness, and awareness (p > 0.05). No delayed reactions were associated with the test lenses. Worn test lenses retained more than 1.5 log inhibition against both bacterial types. Melimine-coated contact lenses were worn safely by humans. However, they were associated with higher corneal staining. The melimine-coated lenses

Inflatable lenses for space photovoltaic concentrator arrays

DOE Office of Scientific and Technical Information (OSTI.GOV)

O`Neill, M.J.; Piszczor, M.F.

1997-12-31

For 12 years, ENTECH and NASA Lewis have been developing Fresnel lens concentrator technology for space power applications. ENTECH provided the point-focus mini-dome lenses for the PASP+ array, launched in 1994. These silicone lenses performed well on orbit, with only about 3% optical performance loss after 1 year in elliptical orbit, with high radiation, atomic oxygen, and ultraviolet exposure. The only protection for these silicone lenses was a thin-film coating provided by OCLI. ENTECH also provided the line-focus lenses for the SCARLET 1 and SCARLET 2 arrays in 1995 and 1997, respectively. These lenses are laminated assemblies, with protective ceriamore » glass superstrates over the silicone lens. In March 1997, ENTECH and NASA Lewis began development of inflatable Fresnel lenses, to achieve lower weight, smaller launch volume, reduced cost, less fragility, and other advantages. This paper summarizes the new concentrator approach, including key program results to date.« less

Transmittance of tinted and UV-blocking disposable contact lenses.

PubMed

Harris, M G; Haririfar, M; Hirano, K Y

1999-03-01

Tinted and ultraviolet (UV)-blocking disposable contact lenses have become increasingly popular over the last decade. Wearers of UV-blocking contact lenses could benefit greatly by protecting their eyes from potential UV radiation damage. A Uvikon 930 dual beam spectrophotometer was used to measure three enhancement-tinted lenses (royal blue, evergreen, and aqua), two types of UV-blocking lenses, and two types of non-UV-blocking lenses. Enhancement-tinted lenses did show a decrease in transmittance at certain wavelengths on the visible spectrum, but they did not reduce the transmittance of UV radiation to the extent of the UV-blocking lenses designed specifically for this purpose.

Contamination risk of reusing daily disposable contact lenses.

PubMed

Boost, Maureen; Poon, Kin-Chiu; Cho, Pauline

2011-12-01

This study investigated contamination of saline and daily disposable contact lens (DDCL) stored overnight after use in the original blister pack and the practices of a group of DDCL users. Twenty DDCL wearers placed their lenses after 1 day's use back into the blister pack saline (BPS) and left them overnight before transferring both lens and BPS to a new CL case. The lens and BPS were cultured the following day, and total number of organisms, Staphylococci, and gram negative organisms enumerated. Each subject submitted five pairs of lenses over a 1 month period. Ninety-five percent of subjects had at least one pair of contaminated lenses, and the BPS yielded similar results to the contaminated lenses, with staphylococcal contamination being predominant. Three subjects admitted to not washing their hands before handling their lenses and six to habitual reuse of their lenses with storage in the BPS. There was a higher risk of contamination in male subjects. Reuse of lenses poses an important risk for DDCL users because they are unlikely to have received proper training in cleaning and disinfection of lenses and do not use a lens case or disinfecting solutions. Overnight storage in BPS results in contaminated lenses which if reused increases the infection risk especially with Staphylococci. It is important that practitioners carefully educate their patients in correct use of DDCL and, as cost of lenses is a major factor in willingness to reuse, ensure that DDCL is the most suitable choice when prescribing.

Design and fabrication of the progressive addition lenses

NASA Astrophysics Data System (ADS)

Qin, Linling; Qian, Lin; Yu, Jingchi

2011-11-01

The use of progressive addition lenses (PALs) for the correction of presbyopia has increased dramatically in recent years. These lenses are now being used as the preferred alternative to bifocal and trifocal lenses in many parts of the world. Progressive addition lenses are a kind of opthalmic lenses with freeform surface. The surface curvature of the Progressive addition lenses varies gradually from a minimum value in the upper area, to a maximum value in the lower area. Thus a PAL has a surface with three zones which have very small astigmatism: far-view zone, near-view zone, and intermediate zone. The far view zone and near view zone have relatively constant powers and connected by the intermediate zone with power varies progressively. The design and fabrication technologies of progressive addition lenses have fast progresses because of the massive development of the optical simulation software, multi-axis ultraprecision machining technologies and CNC machining technologies. The design principles of progressive addition lenses are discussed in a historic review. Several kinds of design methods are illustrated, and their advantages and disadvantages are also represented. In the current study, it is shown that the optical characteristics of the different progressive addition lenses designs are significantly different from one another. The different fabrication technologies of Progressive addition lenses are also discussed in the paper. Plastic injection molding and precision-machine turning are the common fabrication technologies for exterior PALs and Interior PALs respectively.

Discovery of a faint, star-forming, multiply lensed, Lyman-α blob

NASA Astrophysics Data System (ADS)

Caminha, G. B.; Karman, W.; Rosati, P.; Caputi, K. I.; Arrigoni Battaia, F.; Balestra, I.; Grillo, C.; Mercurio, A.; Nonino, M.; Vanzella, E.

2016-11-01

We report the discovery of a multiply lensed Lyman-α blob (LAB) behind the galaxy cluster AS1063 using the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT). The background source is at z = 3.117 and is intrinsically faint compared to almost all previously reported LABs. We used our highly precise strong lensing model to reconstruct the source properties, and we find an intrinsic luminosity of LLyα = 1.9 × 1042 erg s-1, extending to 33 kpc. We find that the LAB is associated with a group of galaxies, and possibly a protocluster, in agreement with previous studies that find LABs in overdensities. In addition to Lyman-α (Lyα) emission, we find C iv, He II, and O III] ultraviolet (UV) emission lines arising from the centre of the nebula. We used the compactness of these lines in combination with the line ratios to conclude that the Lyα nebula is likely powered by embedded star formation. Resonant scattering of the Lyα photons then produces the extended shape of the emission. Thanks to the combined power of MUSE and strong gravitational lensing, we are now able to probe the circumgalatic medium of sub-L∗ galaxies at z ≈ 3.

Time delay in Swiss cheese gravitational lensing

NASA Astrophysics Data System (ADS)

Chen, B.; Kantowski, R.; Dai, X.

2010-08-01

We compute time delays for gravitational lensing in a flat Λ dominated cold dark matter Swiss cheese universe. We assume a primary and secondary pair of light rays are deflected by a single point mass condensation described by a Kottler metric (Schwarzschild with Λ) embedded in an otherwise homogeneous cosmology. We find that the cosmological constant’s effect on the difference in arrival times is nonlinear and at most around 0.002% for a large cluster lens; however, we find differences from time delays predicted by conventional linear lensing theory that can reach ˜4% for these large lenses. The differences in predicted delay times are due to the failure of conventional lensing to incorporate the lensing mass into the mean mass density of the universe.

Irregular Corneas: Improve Visual Function With Scleral Contact Lenses.

PubMed

de Luis Eguileor, Beatriz; Etxebarria Ecenarro, Jaime; Santamaria Carro, Alaitz; Feijoo Lera, Raquel

2018-05-01

To assess visual function in patients with irregular cornea who do not tolerate gas permeable (GP) corneal contact lenses and are fitted with GP scleral contact lenses (Rose K2 XL). In this prospective study, we analyzed 15 eyes of 15 patients who did not tolerate GP corneal contact lenses and were fitted with scleral contact lenses (Rose K2 XL). We assessed visual function using visual acuity and the visual function index (VF-14); we used the VF-14 as an indicator of patient satisfaction. The measurements were taken with the optical correction used before and 1 month after the fitting of the Rose K2 XL contact lenses. We also recorded the number of hours lenses had been worn over the first month. Using Rose K2 XL contact lenses, visual acuity was 0.06±0.07 logMAR. In all cases, visual acuity had improved compared with the measurement before fitting the lenses (0.31±0.18 logMAR; P=0.001). VF-14 scores were 72.74±12.38 before fitting of the scleral lenses, and 89.31±10.87 after 1 month of lens use (P=0.003). Patients used these scleral lenses for 9.33±2.99 comfortable hours of wear. Both visual acuity and VF-14 may improve after fitting Rose K2 XL contact lenses in patients with irregular corneas. In addition, in our patients, these lenses can be worn for a longer period than GP corneal contact lenses.

BD -22 5866: A Low-Mass, Quadruple-lined Spectroscopic and Eclipsing Binary

NASA Astrophysics Data System (ADS)

Shkolnik, Evgenya; Liu, Michael C.; Reid, I. Neill; Hebb, Leslie; Cameron, Andrew C.; Torres, Carlos A.; Wilson, David M.

2008-08-01

We report our discovery of an extremely rare, low-mass, quadruple-lined spectroscopic binary BD -22 5866 (=NLTT 53279, integrated spectral type = M0 V), found during an ongoing search for the youngest M dwarfs in the solar neighborhood. From the cross-correlation function, we are able to measure relative flux levels, estimate the spectral types of the components, and set upper limits on the orbital periods and separations. The resulting system is hierarchical, composed of a K7 + K7 binary and an M1 + M2 binary with semimajor axes of aAsin iA <= 0.06 and aBsin iB <= 0.30 AU. A subsequent search of the SuperWASP photometric database revealed that the K7 + K7 binary is eclipsing with a period of 2.21 days and at an inclination angle of 85°. Within uncertainties of 5%, the masses and radii of both components appear to be equal (0.59 M⊙, 0.61 R⊙). These two tightly orbiting stars (a = 0.035 AU) are in synchronous rotation, causing the observed excess Ca II, Hα, X-ray, and UV emission. The fact that the system was unresolved with published adaptive optics imaging, limits the projected physical separation of the two binaries at the time of the observation to dABlesssim 4.1 AU at the photometric distance of 51 pc. The maximum observed radial velocity difference between the A and B binaries limits the orbit to aABsin iAB <= 6.1 AU. As this tight configuration is difficult to reproduce with current formation models of multiple systems, we speculate that an early dynamical process reduced the size of the system, such as the interaction of the two binaries with a circumquadruple disk. Intensive photometric, spectroscopic, and interferometric monitoring, as well as a parallax measurement of this rare quadruple system, is certainly warranted. Based on observations collected at the W. M. Keck Observatory and the Canada-France-Hawaii Telescope (CFHT). The Keck Observatory is operated as a scientific partnership between the California Institute of Technology, the University

Electrowetting-based liquid lenses for endoscopy

NASA Astrophysics Data System (ADS)

Kuiper, S.

2011-03-01

In endoscopy there is a need for cameras with adjustable focus. In flexible and capsule endoscopes conventional focus systems are not suitable, because of restrictions in diameter and lens displacement range. In this paper it is shown that electrowetting-based variable-focus liquid lenses can provide a solution. A theoretical comparison is made between displacing and deforming lenses, and a demonstrator was built to prove the optical feasibility of focusing with liquid lenses in endoscopes.

EDITORIAL: Focus on Gravitational Lensing

NASA Astrophysics Data System (ADS)

Jain, Bhuvnesh

2007-11-01

Gravitational lensing emerged as an observational field following the 1979 discovery of a doubly imaged quasar lensed by a foreground galaxy. In the 1980s and '90s dozens of other multiply imaged systems were observed, as well as time delay measurements, weak and strong lensing by galaxies and galaxy clusters, and the discovery of microlensing in our galaxy. The rapid pace of advances has continued into the new century. Lensing is currently one of best techniques for finding and mapping dark matter over a wide range of scales, and also addresses broader cosmological questions such as understanding the nature of dark energy. This focus issue of New Journal of Physics presents a snapshot of current research in some of the exciting areas of lensing. It provides an occasion to look back at the advances of the last decade and ahead to the potential of the coming years. Just about a decade ago, microlensing was discovered through the magnification of stars in our galaxy by invisible objects with masses between that of Jupiter and a tenth the mass of the Sun. Thus a new component of the mass of our galaxy, dubbed MACHOs, was established (though a diffuse, cold dark matter-like component is still needed to make up most of the galaxy mass). More recently, microlensing led to another exciting discovery—of extra-solar planets with masses ranging from about five times that of Earth to that of Neptune. We can expect many more planets to be discovered through ongoing surveys. Microlensing is the best technique for finding Earth mass planets, though it is not as productive overall as other methods and does not allow for follow up observations. Beyond planet hunting, microlensing has enabled us to observe previously inaccessible systems, ranging from the surfaces of other stars to the accretion disks around the black holes powering distant quasars. Galaxies and galaxy clusters at cosmological distances can produce dramatic lensing effects: multiple images of background galaxies

Gauge-invariant formalism of cosmological weak lensing

NASA Astrophysics Data System (ADS)

Yoo, Jaiyul; Grimm, Nastassia; Mitsou, Ermis; Amara, Adam; Refregier, Alexandre

2018-04-01

We present the gauge-invariant formalism of cosmological weak lensing, accounting for all the relativistic effects due to the scalar, vector, and tensor perturbations at the linear order. While the light propagation is fully described by the geodesic equation, the relation of the photon wavevector to the physical quantities requires the specification of the frames, where they are defined. By constructing the local tetrad bases at the observer and the source positions, we clarify the relation of the weak lensing observables such as the convergence, the shear, and the rotation to the physical size and shape defined in the source rest-frame and the observed angle and redshift measured in the observer rest-frame. Compared to the standard lensing formalism, additional relativistic effects contribute to all the lensing observables. We explicitly verify the gauge-invariance of the lensing observables and compare our results to previous work. In particular, we demonstrate that even in the presence of the vector and tensor perturbations, the physical rotation of the lensing observables vanishes at the linear order, while the tetrad basis rotates along the light propagation compared to a FRW coordinate. Though the latter is often used as a probe of primordial gravitational waves, the rotation of the tetrad basis is indeed not a physical observable. We further clarify its relation to the E-B decomposition in weak lensing. Our formalism provides a transparent and comprehensive perspective of cosmological weak lensing.

Setting limits on q0 from gravitational lensing

NASA Technical Reports Server (NTRS)

Gott, J. Richard, III; Park, Myeong-Gu; Lee, Hyung Mok

1989-01-01

Gravitational lensing by galaxies in a wide variety of cosmological models is considered. For closed models, the lensing depends on the parameter beta(crit). If beta(crit) is greater than zero, a normal lensing case can be obtained with two bright images separated by an angle twice beta(crit) and a third, arbitrarily dim image between them coincident with the position of the lensing galaxy nucleus. As the QSO approaches the antipodal redshift, which can occur in models with large values of the cosmological constant, the cross sections for lensing blow up. An overfocused case where beta(crit) is less than zero can be obtained for a QSO beyond the antipodal redshift. In this case, when a lensing event occurs, only one arbitrarily dim image coincident with the position of the lensing galaxy nucleus is seen. If galaxy rotation curves are always flat or slowly rising, the overfocused case always produces one image.

LBT/LUCIFER Observations of the z ~ 2 Lensed Galaxy J0900+2234

NASA Astrophysics Data System (ADS)

Bian, Fuyan; Fan, Xiaohui; Bechtold, Jill; McGreer, Ian D.; Just, Dennis W.; Sand, David J.; Green, Richard F.; Thompson, David; Peng, Chien Y.; Seifert, Walter; Ageorges, Nancy; Juette, Marcus; Knierim, Volker; Buschkamp, Peter

2010-12-01

We present rest-frame optical images and spectra of the gravitationally lensed, star-forming galaxy J0900+2234 (z = 2.03). The observations were performed with the newly commissioned LUCIFER1 near-infrared (NIR) instrument mounted on the Large Binocular Telescope. We fitted lens models to the rest-frame optical images and found that the galaxy has an intrinsic effective radius of 7.4 ± 0.8 kpc with a lens magnification factor of about 5 for the A and B components. We also discovered a new arc belonging to another lensed high-z source galaxy, which makes this lens system a potential double Einstein ring system. Using the high signal-to-noise ratio rest-frame spectra covered by the H + K band, we detected Hβ, [O III], Hα, [N II], and [S II] emission lines. Detailed physical properties of this high-z galaxy were derived. The extinction toward the ionized H II regions (Eg (B - V)) was computed from the flux ratio of Hα and Hβ and appears to be much higher than that toward the stellar continuum (Es (B - V)), derived from the optical and NIR broadband photometry fitting. The metallicity was estimated using N2 and O3N2 indices. It is in the range of 1/5-1/3 solar abundance, which is much lower than for typical z ~ 2 star-forming galaxies. From the flux ratio of [S II]λ6717 and [S II]λ6732, we found that the electron number density of the H II regions in the high-z galaxy was sime1000 cm-3, consistent with other z ~ 2 galaxies but much higher than that in local H II regions. The star formation rate was estimated via the Hα luminosity, after correction for the lens magnification, to be about 365 ± 69 M sun yr-1. Combining the FWHM of Hα emission lines and the half-light radius, we found that the dynamical mass of the lensed galaxy is (5.8 ± 0.9) × 1010 M sun. The gas mass is (5.1 ± 1.1) × 1010 M sun from the Hα flux surface density using global Kennicutt-Schmidt law, indicating a very high gas fraction of 0.79 ± 0.19 in J0900+2234. Based on data acquired

Stacked lensing estimators and their covariance matrices: Excess surface mass density vs. Lensing shear

NASA Astrophysics Data System (ADS)

Shirasaki, Masato; Takada, Masahiro

2018-05-01

Stacked lensing is a powerful means of measuring the average mass distribution around large-scale structure tracers. There are two stacked lensing estimators used in the literature, denoted as ΔΣ and γ+, which are related as ΔΣ = Σcrγ+, where Σcr(zl, zs) is the critical surface mass density for each lens-source pair (zl and zs are lens and source redshifts, respectively). In this paper we derive a formula for the covariance matrix of ΔΣ-estimator focusing on "weight" function to improve the signal-to-noise (S/N). We assume that the lensing fields and the distribution of lensing objects obey the Gaussian statistics. With this formula, we show that, if background galaxy shapes are weighted by an amount of Σ _cr^{-2}(z_l,z_s), the ΔΣ-estimator maximizes the S/N in the shot noise limited regime. We also show that the ΔΣ-estimator with the weight Σ _cr^{-2} gives a greater (S/N)2 than that of the γ+-estimator by about 5-25% for lensing objects at redshifts comparable with or higher than the median of source galaxy redshifts for hypothetical Subaru HSC and DES surveys. However, for low-redshift lenses such as zl ≲ 0.3, the γ+-estimator has higher (S/N)2 than ΔΣ. We also discuss that the (S/N)2 for ΔΣ at large separations in the sample variance limited regime can be boosted, by up to a factor of 1.5, if one adopts a weight of Σ _cr^{-α } with α > 2. Our formula allows one to explore how the combination of the different estimators can approach an optimal estimator in all regimes of redshifts and separation scales.

Investigations of Galaxy Clusters Using Gravitational Lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiesner, Matthew P.

2014-08-01

In this dissertation, we discuss the properties of galaxy clusters that have been determined using strong and weak gravitational lensing. A galaxy cluster is a collection of galaxies that are bound together by the force of gravity, while gravitational lensing is the bending of light by gravity. Strong lensing is the formation of arcs or rings of light surrounding clusters and weak lensing is a change in the apparent shapes of many galaxies. In this work we examine the properties of several samples of galaxy clusters using gravitational lensing. In Chapter 1 we introduce astrophysical theory of galaxy clusters andmore » gravitational lensing. In Chapter 2 we examine evidence from our data that galaxy clusters are more concentrated than cosmology would predict. In Chapter 3 we investigate whether our assumptions about the number of galaxies in our clusters was valid by examining new data. In Chapter 4 we describe a determination of a relationship between mass and number of galaxies in a cluster at higher redshift than has been found before. In Chapter 5 we describe a model of the mass distribution in one of the ten lensing systems discovered by our group at Fermilab. Finally in Chapter 6 we summarize our conclusions.« less

Contact lenses to slow progression of myopia.

PubMed

Sankaridurg, Padmaja

2017-09-01

The prevalence of myopia has been steadily rising, with 28 per cent of the global population said to be affected in 2010 and to rise to affect nearly 50 per cent by 2050. Increasing levels of myopia increase the risk of vision impairment and in particular, high myopia is associated with the risk of serious and permanent visual disability due to associated sight-threatening complications. To stem the burden associated with higher levels of myopia, there are efforts to slow the progression of myopia, and several optical and pharmaceutical strategies have been found useful in slowing myopia to varying degrees. More recently, numerous multifocal soft contact lenses and extended depth of focus soft contact lenses (collectively referred to as myopia control contact lenses) were found effective in slowing myopia. As opposed to overnight orthokeratology, myopia control contact lenses are worn during the day and the hypotheses proposed to explain the efficacy of these lenses are generally based on the premise that the stimulus for eye growth is a defocused retinal image with hyperopic blur either centrally or peripherally. Although the individual power profiles of the lenses vary, the contact lens generally incorporates 'positive power' to reduce the hyperopic blur and/or impose myopic defocus or in the case of the extended depth of focus lens, has a power profile designed to optimise retinal image quality for points on or in front of the retina. The use of soft contact lenses as a platform for myopia control offers an exciting and effective avenue to manage myopia but there is a need for further research on issues such as the mechanism underlying control of myopia, improving efficacy with lenses, and understanding rebound on discontinuation. More significantly, although contact lenses are generally safe and improve quality of life in older children, one of the major challenges for improved uptake and acceptance of contact lenses centres on the perceived risk of

Gravitational lensing of active galactic nuclei.

PubMed Central

Hewitt, J N

1995-01-01

Most of the known cases of strong gravitational lensing involve multiple imaging of an active galactic nucleus. The properties of lensed active galactic nuclei make them promising systems for astrophysical applications of gravitational lensing; in particular, they show structure on scales of milliseconds of arc to tens of seconds of arc, they are variable, and they are polarized. More than 20 cases of strong gravitational lenses are now known, and about half of them are radio sources. High-resolution radio imaging is making possible the development of well-constrained lens models. Variability studies at radio and optical wavelengths are beginning to yield results of astrophysical interest, such as an independent measure of the distance scale and limits on source sizes. PMID:11607613

Weak Gravitational Lensing of Finite Beams.

PubMed

Fleury, Pierre; Larena, Julien; Uzan, Jean-Philippe

2017-11-10

The standard theory of weak gravitational lensing relies on the infinitesimal light beam approximation. In this context, images are distorted by convergence and shear, the respective sources of which unphysically depend on the resolution of the distribution of matter-the so-called Ricci-Weyl problem. In this Letter, we propose a strong-lensing-inspired formalism to describe the lensing of finite beams. We address the Ricci-Weyl problem by showing explicitly that convergence is caused by the matter enclosed by the beam, regardless of its distribution. Furthermore, shear turns out to be systematically enhanced by the finiteness of the beam. This implies, in particular, that the Kaiser-Squires relation between shear and convergence is violated, which could have profound consequences on the interpretation of weak-lensing surveys.

Gravitational lensing of active galactic nuclei.

PubMed

Hewitt, J N

1995-12-05

Most of the known cases of strong gravitational lensing involve multiple imaging of an active galactic nucleus. The properties of lensed active galactic nuclei make them promising systems for astrophysical applications of gravitational lensing; in particular, they show structure on scales of milliseconds of arc to tens of seconds of arc, they are variable, and they are polarized. More than 20 cases of strong gravitational lenses are now known, and about half of them are radio sources. High-resolution radio imaging is making possible the development of well-constrained lens models. Variability studies at radio and optical wavelengths are beginning to yield results of astrophysical interest, such as an independent measure of the distance scale and limits on source sizes.

Radio weak lensing shear measurement in the visibility domain - II. Source extraction

NASA Astrophysics Data System (ADS)

Rivi, M.; Miller, L.

2018-05-01

This paper extends the method introduced in Rivi et al. (2016b) to measure galaxy ellipticities in the visibility domain for radio weak lensing surveys. In that paper, we focused on the development and testing of the method for the simple case of individual galaxies located at the phase centre, and proposed to extend it to the realistic case of many sources in the field of view by isolating visibilities of each source with a faceting technique. In this second paper, we present a detailed algorithm for source extraction in the visibility domain and show its effectiveness as a function of the source number density by running simulations of SKA1-MID observations in the band 950-1150 MHz and comparing original and measured values of galaxies' ellipticities. Shear measurements from a realistic population of 104 galaxies randomly located in a field of view of 1 \\deg ^2 (i.e. the source density expected for the current radio weak lensing survey proposal with SKA1) are also performed. At SNR ≥ 10, the multiplicative bias is only a factor 1.5 worse than what found when analysing individual sources, and is still comparable to the bias values reported for similar measurement methods at optical wavelengths. The additive bias is unchanged from the case of individual sources, but it is significantly larger than typically found in optical surveys. This bias depends on the shape of the uv coverage and we suggest that a uv-plane weighting scheme to produce a more isotropic shape could reduce and control additive bias.

Gravitational corrections to light propagation in a perturbed FLRW universe and corresponding weak-lensing spectra

NASA Astrophysics Data System (ADS)

Cuesta-Lazaro, Carolina; Quera-Bofarull, Arnau; Reischke, Robert; Schäfer, Björn Malte

2018-06-01

When the gravitational lensing of the large-scale structure is calculated from a cosmological model a few assumptions enter: (i) one assumes that the photons follow unperturbed background geodesics, which is usually referred to as the Born approximation, (ii) the lenses move slowly, (iii) the source-redshift distribution is evaluated relative to the background quantities, and (iv) the lensing effect is linear in the gravitational potential. Even though these approximations are small individually they could sum up, especially since they include local effects such as the Sachs-Wolfe and peculiar motion, but also non-local ones like the Born approximation and the integrated Sachs-Wolfe effect. In this work, we will address all points mentioned and perturbatively calculate the effect on a tomographic cosmic shear power spectrum of each effect individually as well as all cross-correlations. Our findings show that each effect is at least 4-5 orders of magnitude below the leading order lensing signal. Finally, we sum up all effects to estimate the overall impact on parameter estimation by a future cosmological weak-lensing survey such as Euclid in a wcold dark matter cosmology with parametrization Ωm, σ8, ns, h, w0, and wa, using five tomographic bins. We consistently find a parameter bias of 10-5, which is therefore completely negligible for all practical purposes, confirming that other effects such as intrinsic alignments, magnification bias and uncertainties in the redshift distribution will be the dominant systematic source in future surveys.

CMB-lensing beyond the Born approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marozzi, Giovanni; Fanizza, Giuseppe; Durrer, Ruth

2016-09-01

We investigate the weak lensing corrections to the cosmic microwave background temperature anisotropies considering effects beyond the Born approximation. To this aim, we use the small deflection angle approximation, to connect the lensed and unlensed power spectra, via expressions for the deflection angles up to third order in the gravitational potential. While the small deflection angle approximation has the drawback to be reliable only for multipoles ℓ ∼< 2500, it allows us to consistently take into account the non-Gaussian nature of cosmological perturbation theory beyond the linear level. The contribution to the lensed temperature power spectrum coming from the non-Gaussianmore » nature of the deflection angle at higher order is a new effect which has not been taken into account in the literature so far. It turns out to be the leading contribution among the post-Born lensing corrections. On the other hand, the effect is smaller than corrections coming from non-linearities in the matter power spectrum, and its imprint on CMB lensing is too small to be seen in present experiments.« less

The Alvarez and Lohmann refractive lenses revisited.

PubMed

Barbero, Sergio

2009-05-25

Alvarez and Lohmann lenses are variable focus optical devices based on lateral shifts of two lenses with cubic-type surfaces. I analyzed the optical performance of these types of lenses computing the first order optical properties (applying wavefront refraction and propagation) without the restriction of the thin lens approximation, and the spot diagram using a ray tracing algorithm. I proposed an analytic and numerical method to select the most optimum coefficients and the specific configuration of these lenses. The results show that Lohmann composite lens is slightly superior to Alvarez one because the overall thickness and optical aberrations are smaller.

Lenses matching of compound eye for target positioning

NASA Astrophysics Data System (ADS)

Guo, Fang; Zheng, Yan Pei; Wang, Keyi

2012-10-01

Compound eye, as a new imaging method with multi-lens for a large field of view, could complete target positioning and detection fastly, especially at close range. Therefore it could be applicated in the fields of military and medical treatment and aviation with vast market potential and development prospect. Yet the compound eye imaging method designed use three layer construction of multiple lens array arranged in a curved surface and refractive lens and imaging sensor of CMOS. In order to simplify process structure and increase the imaging area of every sub-eye, the imaging area of every eye is coved with the whole CMOS. Therefore, for several imaging point of one target, the corresponding lens of every imaging point is unkonown, and thus to identify. So an algorithm was put forward. Firstly, according to the Regular Geometry relationship of several adjacent lenses, data organization of seven lenses with a main lens was built. Subsequently, by the data organization, when one target was caught by several unknown lenses, we search every combined type of the received lenses. And for every combined type, two lenses were selected to combine and were used to calculate one three-dimensional (3D) coordinate of the target. If the 3D coordinates are same to the some combine type of the lenses numbers, in theory, the lenses and the imaging points are matched. So according to error of the 3D coordinates is calculated by the different seven lenses numbers combines, the unknown lenses could be distinguished. The experimental results show that the presented algorithm is feasible and can complete matching task for imaging points and corresponding lenses.

Quadruple parallel mass Spectrometry for analysis of vitamin D and triacylglycerols in a dietary supplement

USDA-ARS?s Scientific Manuscript database

A ‘dilute-and-shoot’ method for vitamin D and triacylglycerols is demonstrated that employed four mass spectrometers, operating in different ionization modes, for a ‘quadruple parallel mass spectrometry’ analysis, plus three other detectors, for seven detectors overall. Sets of five samples of diet...

Processes for manufacturing multifocal diffractive-refractive intraocular lenses

NASA Astrophysics Data System (ADS)

Iskakov, I. A.

2017-09-01

Manufacturing methods and design features of modern diffractive-refractive intraocular lenses are discussed. The implantation of multifocal intraocular lenses is the most optimal method of restoring the accommodative ability of the eye after removal of the natural lens. Diffractive-refractive intraocular lenses are the most widely used implantable multifocal lenses worldwide. Existing methods for manufacturing such lenses implement various design solutions to provide the best vision function after surgery. The wide variety of available diffractive-refractive intraocular lens designs reflects the demand for this method of vision correction in clinical practice and the importance of further applied research and development of new technologies for designing improved lens models.

Omni-focal refractive focus correction technology as a substitute for bi/multi-focal intraocular lenses, contact lenses, and spectacles

NASA Astrophysics Data System (ADS)

Ben Yaish, Shai; Zlotnik, Alex; Raveh, Ido; Yehezkel, Oren; Belkin, Michael; Lahav, Karen; Zalevsky, Zeev

2009-02-01

We present novel technology for extension in depth of focus of imaging lenses for use in ophthalmic lenses correcting myopia, hyperopia with regular/irregular astigmatism and presbyopia. This technology produces continuous focus without appreciable loss of energy. It is incorporated as a coating or engraving on the surface for spectacles, contact or intraocular lenses. It was fabricated and tested in simulations and in clinical trials. From the various testing this technology seems to provide a satisfactory single-lens solution. Obtained performance is apparently better than those of existing multi/bifocal lenses and it is modular enough to provide solution to various ophthalmic applications.

GLASS: spatially resolved spectroscopy of lensed galaxies in the Frontier Fields

NASA Astrophysics Data System (ADS)

Jones, Tucker; Treu, Tommaso; Brammer, Gabriel; Borello Schmidt, Kasper; Malkan, Matthew A.

2015-08-01

The Grism Lens-Amplified Survey from Space (GLASS) has obtained slitless near-IR spectroscopy of 10 galaxy clusters selected for their strong lensing properties, including all six Hubble Frontier Fields. Slitless grism spectra are ideal for mapping emission lines such as [O II], [O III], and H alpha at z=1-3. The combination of strong gravitational lensing and HST's diffraction limit provides excellent sensitivity with spatial resolution as fine as 100 pc for highly magnified sources, and ~500 pc for less magnified sources near the edge of the field of view. The GLASS survey represents the largest spectroscopic sample with such high resolution at z>1. GLASS and Hubble Frontier Field data provide the distribution of stellar mass, star formation, gas-phase metallicity, and other aspects of the physical structure of high redshift galaxies, reaching unprecedented stellar masses as low as ~10^7 Msun at z=2. I will discuss precise measurements of these physical properties and implications for galaxy evolution.

First-line treatment of Helicobacter pylori in Lebanon: Comparison of bismuth-containing quadruple therapy versus 14-days sequential therapy.

PubMed

Tarhini, Mahdi; Fayyad-Kazan, Mohammad; Fayyad-Kazan, Hussein; Mokbel, Mahmoud; Nasreddine, Mohammad; Badran, Bassam; Kchour, Ghada

2018-04-01

Helicobacter Pylori (H. Pylori) is the most common cause of peptic ulcer disease (PUD) and represents a strong risk factor for gastric cancer. Treatment of H. Pylori is, therefore, a persistent need to avoid serious medical complications. Resistance to antibiotics remains to be the major challenge for H. Pylori eradication. In this study, we determined the prevalence of H. pylori infection and evaluated H. pylori eradication efficacy of bismuth-containing quadruple therapy (Pylera) versus 14-days sequential therapy in treatment naïve-Lebanese patients. 1030 patients, showing symptoms of peptic ulcer (PU) and gastritis, underwent 14 C-Urea Breath Test and esophagogastroduodenoscopy to examine H. Pylori infection and gastrointestinal disorders. Among the H. Pylori-positive patients 60 individuals were randomly selected, separated into two groups (each consisting of 30 patients) and treated with either bismuth-containing quadruple therapy or 14-days sequential therapy. We show that of the 1050 patients tested: 46.2% were H. pylori-positive, 55% had gastritis, 46.2% had both gastritis and H. pylori infection, 8.8% had gastritis but no H. pylori infection, 44.9% had neither gastritis nor H. pylori infection. Following the 14-days sequential therapy, the eradication rate was significantly higher than that obtained upon using bismuth-containing quadruple therapy [80% (24/30) versus 50% (15/30), χ 2  = 5.93, P = 0.015]. In conclusion, we determined H. pylori and gastritis prevalence among Lebanese PU-patients and showed that 14-days sequential therapy is more efficient than bismuth-containing quadruple therapy in terms of H. Pylori-eradication. Published by Elsevier Ltd.

Direct Shear Mapping: Prospects for Weak Lensing Studies of Individual Galaxy-Galaxy Lensing Systems

NASA Astrophysics Data System (ADS)

de Burgh-Day, C. O.; Taylor, E. N.; Webster, R. L.; Hopkins, A. M.

2015-11-01

Using both a theoretical and an empirical approach, we have investigated the frequency of low redshift galaxy-galaxy lensing systems in which the signature of 3D weak lensing might be directly detectable. We find good agreement between these two approaches. Using data from the Galaxy and Mass Assembly redshift survey we estimate the frequency of detectable weak lensing at low redshift. We find that below a redshift of z ~ 0.6, the probability of a galaxy being weakly lensed by γ ⩾ 0.02 is ~ 0.01. We have also investigated the feasibility of measuring the scatter in the M * - Mh relation using shear statistics. We estimate that for a shear measurement error of Δγ = 0.02 (consistent with the sensitivity of the Direct Shear Mapping technique), with a sample of ~50,000 spatially and spectrally resolved galaxies, the scatter in the M * - Mh relation could be measured. While there are currently no existing IFU surveys of this size, there are upcoming surveys that will provide this data (e.g The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX), surveys with Hector, and the Square Kilometre Array (SKA)).

Factors influencing bacterial adhesion to contact lenses.

PubMed

Dutta, Debarun; Cole, Nerida; Willcox, Mark

2012-01-01

The process of any contact lens related keratitis generally starts with the adhesion of opportunistic pathogens to contact lens surface. This article focuses on identifying the factors which have been reported to affect bacterial adhesion to contact lenses. Adhesion to lenses differs between various genera/species/strains of bacteria. Pseudomonas aeruginosa, which is the predominant causative organism, adheres in the highest numbers to both hydrogel and silicone hydrogel lenses in vitro. The adhesion of this strain reaches maximum numbers within 1h in most in vitro studies and a biofilm has generally formed within 24 h of cells adhering to the lens surface. Physical and chemical properties of contact lens material affect bacterial adhesion. The water content of hydroxyethylmethacrylate (HEMA)-based lenses and their iconicity affect the ability of bacteria to adhere. The higher hydrophobicity of silicone hydrogel lenses compared to HEMA-based lenses has been implicated in the higher numbers of bacteria that can adhere to their surfaces. Lens wear has different effects on bacterial adhesion, partly due to differences between wearers, responses of bacterial strains and the ability of certain tear film proteins when bound to a lens surface to kill certain types of bacteria.

Factors influencing bacterial adhesion to contact lenses

PubMed Central

Dutta, Debarun; Willcox, Mark

2012-01-01

The process of any contact lens related keratitis generally starts with the adhesion of opportunistic pathogens to contact lens surface. This article focuses on identifying the factors which have been reported to affect bacterial adhesion to contact lenses. Adhesion to lenses differs between various genera/species/strains of bacteria. Pseudomonas aeruginosa, which is the predominant causative organism, adheres in the highest numbers to both hydrogel and silicone hydrogel lenses in vitro. The adhesion of this strain reaches maximum numbers within 1h in most in vitro studies and a biofilm has generally formed within 24 h of cells adhering to the lens surface. Physical and chemical properties of contact lens material affect bacterial adhesion. The water content of hydroxyethylmethacrylate (HEMA)-based lenses and their iconicity affect the ability of bacteria to adhere. The higher hydrophobicity of silicone hydrogel lenses compared to HEMA-based lenses has been implicated in the higher numbers of bacteria that can adhere to their surfaces. Lens wear has different effects on bacterial adhesion, partly due to differences between wearers, responses of bacterial strains and the ability of certain tear film proteins when bound to a lens surface to kill certain types of bacteria. PMID:22259220

Optical millimeter-wave signal generation by frequency quadrupling using one dual-drive Mach-Zehnder modulator to overcome chromatic dispersion

NASA Astrophysics Data System (ADS)

Zhu, Zihang; Zhao, Shanghong; Yao, Zhoushi; Tan, Qinggui; Li, Yongjun; Chu, Xingchun; Shi, Lei; Zhang, Xi

2012-06-01

We propose a novel approach to generate quadrupling-frequency optical millimeter-wave using a dual-drive Mach-Zehnder modulator (MZM) in radio-over-fiber system. By properly adjusting the phase difference in the two modulation arms of MZM, the direct current (DC) bias, the modulation index and the gain of base-band signal, the quadrupling-frequency optical millimeter-wave with signal only carried by one second-order sideband is generated. As the signal is transmitted along the fiber, there is no time shift of the codes caused by chromatic dispersion. Theoretical analysis and simulation results show that the eye diagram keeps open and clear even when the quadrupling-frequency optical millimeter-wave are transmitted over 110 km and the power penalty is about 0.45 dB after fiber transmission distance of 60 km. Furthermore, due to another second-order sideband carrying no signals, a full duplex radio-over-fiber link based on wavelength reuse is also built to simplify the base station. The bidirectional 2.5 Gbit/s data is successfully transmitted over 40 km standard single mode fiber with less than 0.6 dB power penalty in the simulation.

First quadruple-glycine bridging mono-lanthanide-substituted borotungstate hybrids.

PubMed

Liu, Jiancai; Yu, Jing; Han, Qing; Wen, Yue; Chen, Lijuan; Zhao, Junwei

2016-10-18

A class of novel organic-inorganic hybrid lanthanide (Ln)-substituted Keggin-type borotungstates K 4 Na 4 H 4 [Ln 2 (gly) 4 (α-BW 11 O 39 ) 2 ]·23H 2 O [Ln = Ce 3+ (1), Pr 3+ (2), Nd 3+ (3), Sm 3+ (4), Eu 3+ (5), Tm 3+ (6); gly = glycine] have been synthesized from the reaction of K 8 [BW 11 O 39 H]·13H 2 O, NaAc·6H 2 O and Ln(NO 3 ) 3 ·6H 2 O by employing gly ligands as structure-stabilizing agents in the conventional aqueous solution system and structurally characterized by elemental analyses, IR spectroscopy, thermogravimetric (TG) analyses, powder X-ray diffraction (PXRD) and single-crystal X-ray diffraction. The common prominent structural feature of isomorphic 1-6 is that all of them consist of two mono-Ln-substituted Keggin [Ln(α-BW 11 O 39 )] 6- fragments linked by four gly ligands, furnishing an intriguing dimeric assembly of the quadruple-gly-connective mono-Ln-substituted borotungstate, in which each carboxylic oxygen atom from gly ligands is bound to Ln 3+ cations in the μ 2 -O or μ 3 -O mode. To the best of our knowledge, 1-6 represent the first examples of inorganic-organic hybrid Ln-substituted borotungstates functionalized by quadruple amino acid bridges. The solid-state photoluminescence properties of 3-5 have been determined at ambient temperature and the photoluminescence emission spectra exhibit the characteristic emission bands derived from Ln 3+ centers. The thermostability of 1-6 has been studied and the thermal decomposition procedure of 3 has been comprehensively investigated with the assistance of variable-temperature PXRD patterns and variable-temperature IR spectra. Furthermore, magnetic susceptibility measurements of 1, 2 and 4 have been conducted.

Multifocal lenses in coral reef fishes.

PubMed

Karpestam, Björn; Gustafsson, Jonas; Shashar, Nadav; Katzir, Gadi; Kröger, Ronald H H

2007-08-01

The optical properties of crystalline lenses were studied in eleven species of coral reef fish from the Red Sea in Eilat, Israel. Three species each of diurnal planktivores, nocturnal planktivores and diurnal herbivores constituted three groups of animals with little within-group variability. In addition we studied two predators, which differed with respect to body size, prey preference, hunting method and diel activity period. All species studied have multifocal lenses. There were statistically significant differences in the optical properties of the lenses between the first three groups and between the predatory species. The properties of the lenses correlate well with known complements of visual pigments and feeding habits. Lenticular zones focusing ultraviolet light were found in two diurnal planktivores. The optical properties of the lens seem to be specifically adapted to the visual needs of each species.

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg(2) of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of z(med) similar to 0.7, while the CMB lensing kernel is broad and peaks at z similar to 2. The resulting cross-correlation is maximally sensitivemore » to mass fluctuations at z similar to 0.44. Assuming the Planck 2015 best-fitting cosmology, the amplitude of the DESxSPT cross-power is found to be A(SPT) = 0.88 +/- 0.30 and that from DESxPlanck to be A(Planck) = 0.86 +/- 0.39, where A = 1 corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of 2.9 sigma and 2.2 sigma, respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photo-z uncertainty and CMB lensing systematics. We calculate a value of A = 1.08 +/- 0.36 for DESxSPT when we correct the observations with a simple intrinsic alignment model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation. We provide forecasts for the expected signal-to-noise ratio of the combination of the five-year DES survey and SPT-3G.« less

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

NASA Astrophysics Data System (ADS)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.; Cawthon, R.; Chang, C.; Larsen, P.; Amara, A.; Bacon, D.; Crawford, T. M.; Dodelson, S.; Fosalba, P.; Giannantonio, T.; Holder, G.; Jain, B.; Kacprzak, T.; Lahav, O.; MacCrann, N.; Nicola, A.; Refregier, A.; Sheldon, E.; Story, K. T.; Troxel, M. A.; Vieira, J. D.; Vikram, V.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Becker, M. R.; Benson, B. A.; Bernstein, G. M.; Bernstein, R. A.; Bleem, L. E.; Bonnett, C.; Bridle, S. L.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carlstrom, J. E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Flaugher, B.; Frieman, J.; Gerdes, D. W.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Honscheid, K.; James, D. J.; Jarvis, M.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lima, M.; March, M.; Martini, P.; Melchior, P.; Miller, C. J.; Miquel, R.; Nichol, R. C.; Ogando, R.; Plazas, A. A.; Reichardt, C. L.; Roodman, A.; Rozo, E.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Simard, G.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Wechsler, R. H.; Weller, J.

2016-06-01

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg2 of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of zmed ˜ 0.7, while the CMB lensing kernel is broad and peaks at z ˜ 2. The resulting cross-correlation is maximally sensitive to mass fluctuations at z ˜ 0.44. Assuming the Planck 2015 best-fitting cosmology, the amplitude of the DES×SPT cross-power is found to be ASPT = 0.88 ± 0.30 and that from DES×Planck to be APlanck = 0.86 ± 0.39, where A = 1 corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of 2.9σ and 2.2σ, respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photo-z uncertainty and CMB lensing systematics. We calculate a value of A = 1.08 ± 0.36 for DES×SPT when we correct the observations with a simple intrinsic alignment model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation. We provide forecasts for the expected signal-to-noise ratio of the combination of the five-year DES survey and SPT-3G.

Do swimming goggles limit microbial contamination of contact lenses?

PubMed

Wu, Yvonne T; Tran, Jess; Truong, Michelle; Harmis, Najat; Zhu, Hua; Stapleton, Fiona

2011-04-01

Wearing goggles over contact lenses while swimming is often recommended by eye care professionals. Limited data are available to assess this recommendation. The purpose of this study was to examine whether wearing goggles while swimming limits bacterial colonization on contact lenses and whether the type of lens worn affects contamination rates. Twenty-three subjects underwent two swimming sessions at an ocean (salt water) pool (Maroubra beach Rock Pool, Sydney, Australia). Silicone hydrogel (Ciba Focus Night and Day) or hydrogel lenses (Ciba Focus Daily) were inserted into subjects' eyes before 30 min of swimming sessions, and subjects used modified goggles to mimic goggled and non-goggled conditions. At the end of each session, lenses were collected for microbial investigation. Viable bacterial colonies were classified as gram positive and gram negative and enumerated. The level of bacterial colonization on contact lenses between goggled and non-goggled conditions and between the two lens materials were compared. The range of colony forming units recovered from goggled lenses were 0 to 930 compared with 0 to 1210 on non-goggled lenses. The majority of subjects (16/23) had more microorganisms in the non-goggled condition than when wearing goggles (p = 0.03). Gram negative organisms were found in three non-goggled lenses. No significant difference was shown in the number of bacteria isolated from silicone hydrogel and hydrogel lenses (p > 0.6) irrespective of wearing goggles. Water samples had consistently higher numbers of bacterial counts than those adhered to the lenses; however, no association was found between the number of bacteria in the water sample and those found on the contact lenses. Consistently, fewer bacterial colonies were found on the goggled contact lens, thus suggesting goggles offer some protection against bacterial colonization of contact lenses while swimming. These data would support the recommendation encouraging lens wearers to use goggles

Epi-detected quadruple-modal nonlinear optical microscopy for label-free imaging of the tooth

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Zi; Zheng, Wei; Huang, Zhiwei, E-mail: biehzw@nus.edu.sg

2015-01-19

We present an epi-detected quadruple-modal nonlinear optical microscopic imaging technique (i.e., coherent anti-Stokes Raman scattering (CARS), second-harmonic generation (SHG), third-harmonic generation (THG), and two-photon excited fluorescence (TPEF)) based on a picosecond (ps) laser-pumped optical parametric oscillator system for label-free imaging of the tooth. We demonstrate that high contrast ps-CARS images covering both the fingerprint (500–1800 cm{sup −1}) and high-wavenumber (2500–3800 cm{sup −1}) regions can be acquired to uncover the distributions of mineral and organic biomaterials in the tooth, while high quality TPEF, SHG, and THG images of the tooth can also be acquired under ps laser excitation without damaging the samples. Themore » quadruple-modal nonlinear microscopic images (CARS/SHG/THG/TPEF) acquired provide better understanding of morphological structures and biochemical/biomolecular distributions in the dentin, enamel, and the dentin-enamel junction of the tooth without labeling, facilitating optical diagnosis and characterization of the tooth in dentistry.« less

Cosmology with weak lensing surveys.

PubMed

Munshi, Dipak; Valageas, Patrick

2005-12-15

Weak gravitational lensing is responsible for the shearing and magnification of the images of high-redshift sources due to the presence of intervening mass. Since the lensing effects arise from deflections of the light rays due to fluctuations of the gravitational potential, they can be directly related to the underlying density field of the large-scale structures. Weak gravitational surveys are complementary to both galaxy surveys and cosmic microwave background observations as they probe unbiased nonlinear matter power spectra at medium redshift. Ongoing CMBR experiments such as WMAP and a future Planck satellite mission will measure the standard cosmological parameters with unprecedented accuracy. The focus of attention will then shift to understanding the nature of dark matter and vacuum energy: several recent studies suggest that lensing is the best method for constraining the dark energy equation of state. During the next 5 year period, ongoing and future weak lensing surveys such as the Joint Dark Energy Mission (JDEM; e.g. SNAP) or the Large-aperture Synoptic Survey Telescope will play a major role in advancing our understanding of the universe in this direction. In this review article, we describe various aspects of probing the matter power spectrum and the bi-spectrum and other related statistics with weak lensing surveys. This can be used to probe the background dynamics of the universe as well as the nature of dark matter and dark energy.

A strong-lensing elliptical galaxy in the MaNGA survey

NASA Astrophysics Data System (ADS)

Smith, Russell J.

2017-01-01

I report discovery of a new galaxy-scale gravitational lens system, identified using public data from the Mapping Galaxies at Apache Point Observatory (MaNGA) survey, as part of a systematic search for lensed background line emitters. The lens is SDSS J170124.01+372258.0, a giant elliptical galaxy with velocity dispersion σ = 256 km s-1, at a redshift of zl = 0.122. After modelling and subtracting the target galaxy light, the integral-field data cube reveals [O II], [O III] and Hβ emission lines corresponding to a source at zs = 0.791, forming an identifiable ring around the galaxy centre. If the ring is formed by a single lensed source, then the Einstein radius is REin ≈ 2.3 arcsec, projecting to ˜5 kpc at the distance of the lens. The total projected lensing mass is MEin = (3.6 ± 0.6) × 1011 M⊙, and the total J-band mass-to-light ratio is 3.0 ± 0.7 solar units. Plausible estimates of the likely dark matter content could reconcile this with a Milky Way-like initial mass function (IMF), for which M/L ≈ 1.5 is expected, but heavier IMFs are by no means excluded with the present data. An alternative interpretation of the system, with a more complex source plane, is also discussed. The discovery of this system bodes well for future lens searches based on MaNGA and other integral-field spectroscopic surveys.

Variable practice with lenses improves visuo-motor plasticity

NASA Technical Reports Server (NTRS)

Roller, C. A.; Cohen, H. S.; Kimball, K. T.; Bloomberg, J. J.

2001-01-01

Novel sensorimotor situations present a unique challenge to an individual's adaptive ability. Using the simple and easily measured paradigm of visual-motor rearrangement created by the use of visual displacement lenses, we sought to determine whether an individual's ability to adapt to visuo-motor discordance could be improved through training. Subjects threw small balls at a stationary target during a 3-week practice regimen involving repeated exposure to one set of lenses in block practice (x 2.0 magnifying lenses), multiple sets of lenses in variable practice (x 2.0 magnifying, x 0.5 minifying and up-down reversing lenses) or sham lenses. At the end of training, adaptation to a novel visuo-motor situation (20-degree right shift lenses) was tested. We found that (1) training with variable practice can increase adaptability to a novel visuo-motor situation, (2) increased adaptability is retained for at least 1 month and is transferable to further novel visuo-motor permutations and (3) variable practice improves performance of a simple motor task even in the undisturbed state. These results have implications for the design of clinical rehabilitation programs and countermeasures to enhance astronaut adaptability, facilitating adaptive transitions between gravitational environments.

Radiation Blocking Lenses

NASA Technical Reports Server (NTRS)

1989-01-01

Biomedical Optical Company of America's (BOCA) suntiger lenses, similar in principle to natural filters in the eyes of hawks and eagles, bar 99 percent of potentially harmful wavelengths, while allowing visually useful colors of light (red, orange, green) to pass through. They also improve visual acuity, night vision and haze or fog visibility. The lenses evolved from work done by James B. Stephens and Dr. Charles G. Miller of the Jet Propulsion Laboratory. They developed a formula and produced a commercial welding curtain that absorbs, filters, and scatters light. This research led to protective glasses now used by dentists, workers in hazardous environments, CRT operators and skiers.

Ten-day bismuth-containing quadruple therapy is effective as first-line therapy for Helicobacter pylori-related chronic gastritis: a prospective randomized study in China.

PubMed

Wang, L; Lin, Z; Chen, S; Li, J; Chen, C; Huang, Z; Ye, B; Ding, J; Li, W; Wu, L; Jiang, Y; Meng, L; Du, Q; Si, J

2017-06-01

To investigate the effectiveness of 10-day bismuth-containing quadruple (B-quadruple) treatment as first-line therapy in patients with Helicobacter pylori-related chronic gastritis. A randomized controlled trial was conducted from October 2011 to December 2013 in Zhejiang, China, including patients with H. pylori-related chronic gastritis who were randomly provided either 10-day omeprazole-based triple therapy (OM-triple; omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily) or 10-day B-quadruple therapy (OM-triple + bismuth subcitrate 120 mg four times daily). H. pylori status, pathologic findings and dyspeptic symptoms were assessed at baseline and after 3 months. The primary outcome was H. pylori eradication rates by intention-to-treat (ITT) and per-protocol (PP) analyses. The secondary outcomes were the histologic and symptomatic benefits from H. pylori eradication. A total of 351 patients with H. pylori-related chronic gastritis were recruited. The eradication rates of the OM-triple and B-quadruple groups were 58.4% (108/185) and 86.1% (143/166) respectively according to ITT analysis (p <0.01). PP rates of H. pylori eradication were 63.2% (108/171) and 92.3% (143/155) respectively (p <0.01). According to the PP analysis, active and chronic inflammation in gastric mucosa was substantially improved in all treated patients (n=326). However, pathologic atrophic gastritis and intestinal metaplasia did not regress in both groups (n=326). The reduction of dyspeptic symptoms score was significantly higher in the B-quadruple group than in the OM-triple group (0.59±0.057 vs. 0.39±0.046) (p <0.01). Ten-day B-quadruple therapy is more effective than OM-triple therapy as first-line therapy for patients with H. pylori-induced chronic gastritis in China. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. XVI. Time delays for the quadruply imaged quasar DES J0408-5354 with high-cadence photometric monitoring

NASA Astrophysics Data System (ADS)

Courbin, F.; Bonvin, V.; Buckley-Geer, E.; Fassnacht, C. D.; Frieman, J.; Lin, H.; Marshall, P. J.; Suyu, S. H.; Treu, T.; Anguita, T.; Motta, V.; Meylan, G.; Paic, E.; Tewes, M.; Agnello, A.; Chao, D. C.-Y.; Chijani, M.; Gilman, D.; Rojas, K.; Williams, P.; Hempel, A.; Kim, S.; Lachaume, R.; Rabus, M.; Abbott, T. M. C.; Allam, S.; Annis, J.; Banerji, M.; Bechtol, K.; Benoit-Lévy, A.; Brooks, D.; Burke, D. L.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; D'Andrea, C. B.; da Costa, L. N.; Davis, C.; DePoy, D. L.; Desai, S.; Flaugher, B.; Fosalba, P.; García-Bellido, J.; Gaztanaga, E.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lahav, O.; Lima, M.; Maia, M. A. G.; March, M.; Marshall, J. L.; McMahon, R. G.; Menanteau, F.; Miquel, R.; Nord, B.; Plazas, A. A.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, M.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Tucker, D. L.; Walker, A. R.; Wester, W.

2018-01-01

We present time-delay measurements for the new quadruple imaged quasar DES J0408-5354, the first quadruple imaged quasar found in the Dark Energy Survey (DES). Our result is made possible by implementing a new observational strategy using almost daily observations with the MPIA 2.2 m telescope at La Silla observatory and deep exposures reaching a signal-to-noise ratio of about 1000 per quasar image. This data qualityallows us to catch small photometric variations (a few mmag rms) of the quasar, acting on temporal scales much shorter than microlensing, and hence making the time delay measurement very robust against microlensing. In only seven months we very accurately measured one of the time delays in DES J0408-5354: Δt(AB) = -112.1 ± 2.1 days (1.8%) using only the MPIA 2.2 m data. In combination with data taken with the 1.2 m Euler Swiss telescope, we also measured two delays involving the D component of the system Δt(AD) = -155.5 ± 12.8 days (8.2%) and Δt(BD) = -42.4 ± 17.6 days (41%), where all the error bars include systematics. Turning these time delays into cosmological constraints will require deep Hubble Space Telescope (HST) imaging or ground-based adaptive optics (AO), and information on the velocity field of the lensing galaxy. Lightcurves are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/609/A71

Predicting gravitational lensing by stellar remnants

NASA Astrophysics Data System (ADS)

Harding, Alexander J.; Stefano, R. Di; Lépine, S.; Urama, J.; Pham, D.; Baker, C.

2018-03-01

Gravitational lensing provides a means to measure mass that does not rely on detecting and analysing light from the lens itself. Compact objects are ideal gravitational lenses, because they have relatively large masses and are dim. In this paper, we describe the prospects for predicting lensing events generated by the local population of compact objects, consisting of 250 neutron stars, five black holes, and ≈35 000 white dwarfs. By focusing on a population of nearby compact objects with measured proper motions and known distances from us, we can measure their masses by studying the characteristics of any lensing event they generate. Here, we concentrate on shifts in the position of a background source due to lensing by a foreground compact object. With Hubble Space Telescope, JWST, and Gaia, measurable centroid shifts caused by lensing are relatively frequent occurrences. We find that 30-50 detectable events per decade are expected for white dwarfs. Because relatively few neutron stars and black holes have measured distances and proper motions, it is more difficult to compute realistic rates for them. However, we show that at least one isolated neutron star has likely produced detectable events during the past several decades. This work is particularly relevant to the upcoming data releases by the Gaia mission and also to data that will be collected by JWST. Monitoring predicted microlensing events will not only help to determine the masses of compact objects, but will also potentially discover dim companions to these stellar remnants, including orbiting exoplanets.

Fresnel Lenses for Wide-Aperture Optical Receivers

NASA Technical Reports Server (NTRS)

Hemmati, Hamid

2004-01-01

Wide-aperture receivers for freespace optical communication systems would utilize Fresnel lenses instead of conventional telescope lenses, according to a proposal. Fresnel lenses weigh and cost much less than conventional lenses having equal aperture widths. Plastic Fresnel lenses are commercially available in diameters up to 5 m large enough to satisfy requirements for aperture widths of the order of meters for collecting sufficient light in typical long-distance free-space optical communication systems. Fresnel lenses are not yet suitable for high-quality diffraction-limited imaging, especially in polychromatic light. However, optical communication systems utilize monochromatic light, and there is no requirement for high-quality imaging; instead, the basic requirement for an optical receiver is to collect the incoming monochromatic light over a wide aperture and concentrate the light onto a photodetector. Because of lens aberrations and diffraction, the light passing through any lens is focused to a blur circle rather than to a point. Calculations for some representative cases of wide-aperture non-diffraction-limited Fresnel lenses have shown that it should be possible to attain blur-circle diameters of less than 2 mm. Preferably, the blur-circle diameter should match the width of the photodetector. For most high-bandwidth communication applications, the required photodetector diameters would be about 1 mm. In a less-preferable case in which the blur circle was wider than a single photodetector, it would be possible to occupy the blur circle with an array of photodetectors. As an alternative to using a single large Fresnel lens, one could use an array of somewhat smaller lenses to synthesize the equivalent aperture area. Such a configuration might be preferable in a case in which a single Fresnel lens of the requisite large size would be impractical to manufacture, and the blur circle could not be made small enough. For example one could construct a square array

Autostereoscopic display based on two-layer lenticular lenses.

PubMed

Zhao, Wu-Xiang; Wang, Qiong-Hua; Wang, Ai-Hong; Li, Da-Hai

2010-12-15

An autostereoscopic display based on two-layer lenticular lenses is proposed. The two-layer lenticular lenses include one-layer conventional lenticular lenses and additional one-layer concentrating-light lenticular lenses. Two prototypes of the proposed and conventional autostereoscopic displays are developed. At the optimum three-dimensional view distance, the luminance distribution of the prototypes along the horizontal direction is measured. By calculating the luminance distribution, the crosstalk of the prototypes is obtained. Compared with the conventional autostereoscopic display, the proposed autostereoscopic display has less crosstalk, a wider view angle, and higher efficiency of light utilization.

Effect of lensing non-Gaussianity on the CMB power spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Pratten, Geraint, E-mail: antony@cosmologist.info, E-mail: geraint.pratten@gmail.com

2016-12-01

Observed CMB anisotropies are lensed, and the lensed power spectra can be calculated accurately assuming the lensing deflections are Gaussian. However, the lensing deflections are actually slightly non-Gaussian due to both non-linear large-scale structure growth and post-Born corrections. We calculate the leading correction to the lensed CMB power spectra from the non-Gaussianity, which is determined by the lensing bispectrum. Assuming no primordial non-Gaussianity, the lowest-order result gives ∼ 0.3% corrections to the BB and EE polarization spectra on small-scales. However we show that the effect on EE is reduced by about a factor of two by higher-order Gaussian lensing smoothing,more » rendering the total effect safely negligible for the foreseeable future. We give a simple analytic model for the signal expected from skewness of the large-scale lensing field; the effect is similar to a net demagnification and hence a small change in acoustic scale (and therefore out of phase with the dominant lensing smoothing that predominantly affects the peaks and troughs of the power spectrum).« less

Weak Lensing by Galaxy Clusters: from Pixels to Cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gruen, Daniel

The story of the origin and evolution of our Universe is told, equivalently, by space-time itself and by the structures that grow inside of it. Clusters of galaxies are the frontier of bottom-up structure formation. They are the most massive objects to have collapsed at the present epoch. By that virtue, their abundance and structural parameters are highly sensitive to the composition and evolution of the Universe. The most common probe of cluster cosmology, abundance, uses samples of clusters selected by some observable. Applying a mass-observable relation (MOR), cosmological parameters can be constrained by comparing the sample to predicted clustermore » abundances as a function of observable and redshift. Arguably, however, cluster probes have not yet entered the era of per cent level precision cosmology. The primary reason for this is our imperfect understanding of the MORs. The overall normalization, the slope of mass vs. observable, the redshift evolution, and the degree and correlation of intrinsic scatters of observables at fixed mass have to be constrained for interpreting abundances correctly. Mass measurement of clusters by means of the differential deflection of light from background sources in their gravitational field, i.e. weak lensing, is a powerful approach for achieving this. This thesis presents new methods for and scientific results of weak lensing measurements of clusters of galaxies. The former include, on the data reduction side, (i) the correction of CCD images for non-linear effects due to the electric fields of accumulated charges and (ii) a method for masking artifact features in sets of overlapping images of the sky by comparison to the median image. Also, (iii) I develop a method for the selection of background galaxy samples based on their color and apparent magnitude that includes a new correction for contamination with cluster member galaxies. The main scientific results are the following. (i) For the Hubble Frontier Field cluster

Illumination-redistribution lenses for non-circular spots

NASA Astrophysics Data System (ADS)

Parkyn, William A.; Pelka, David G.

2005-08-01

The design of illumination lenses is far easier under the regime of the small-source approximation, whereby central rays are taken as representative of the entire source. This implies that the lens is much larger than the source's active emitter, and its entire interior surface is nowhere close to the source. Also, a given source luminance requires a minimum lens area to achieve the candlepower necessary for target illumination. We introduce two-surface aspheric lenses for specific illuminations tasks involving ceiling-mounted downlights, lenses that achieve uniform illuminance at the output aperture as well as at the target. This means that squared-off lenses will produce square spots. In particular, a semicircular lens and a vertical mirror will produce a semicircular spot suitable for gambling tables.

Research on Hartmann test for progressive addition lenses

NASA Astrophysics Data System (ADS)

Qin, Lin-ling; Yu, Jing-chi

2009-05-01

Recently, in the world some growing-up measurements for Progressive addition lenses and relevant equipments have been developed. They are single point measurement, moiré deflectometry, Ronchi test techniques. Hartmann test for Progressive addition lenses is proposed in the article. The measurement principle of Hartmann test for ophthalmic lenses and the power compensation of off-axis rays are introduced. The experimental setup used to test lenses is put forward. For experimental test, a spatial filter is used for selecting a clean Gaussian beam; a collimating lens with focal distance f =300 mm is used to produce collimated beam. The Hartmann plate with a square array of holes separated at 2 mm is selected. The selection of laser and CCD camera is critical to the accuracy of experiment and the image processing algorithm. The spot patterns from CCD are obtained from the experimental tests. The power distribution map for lenses can be obtained by image processing in theory. The results indicate that Hartmann test for Progressive addition lenses is convenient and feasible; also its structure is simple.

The Initial Mass Function in the Nearest Strong Lenses from SNELLS: Assessing the Consistency of Lensing, Dynamical, and Spectroscopic Constraints

NASA Astrophysics Data System (ADS)

Newman, Andrew B.; Smith, Russell J.; Conroy, Charlie; Villaume, Alexa; van Dokkum, Pieter

2017-08-01

We present new observations of the three nearest early-type galaxy (ETG) strong lenses discovered in the SINFONI Nearby Elliptical Lens Locator Survey (SNELLS). Based on their lensing masses, these ETGs were inferred to have a stellar initial mass function (IMF) consistent with that of the Milky Way, not the bottom-heavy IMF that has been reported as typical for high-σ ETGs based on lensing, dynamical, and stellar population synthesis techniques. We use these unique systems to test the consistency of IMF estimates derived from different methods. We first estimate the stellar M */L using lensing and stellar dynamics. We then fit high-quality optical spectra of the lenses using an updated version of the stellar population synthesis models developed by Conroy & van Dokkum. When examined individually, we find good agreement among these methods for one galaxy. The other two galaxies show 2-3σ tension with lensing estimates, depending on the dark matter contribution, when considering IMFs that extend to 0.08 M ⊙. Allowing a variable low-mass cutoff or a nonparametric form of the IMF reduces the tension among the IMF estimates to <2σ. There is moderate evidence for a reduced number of low-mass stars in the SNELLS spectra, but no such evidence in a composite spectrum of matched-σ ETGs drawn from the SDSS. Such variation in the form of the IMF at low stellar masses (m ≲ 0.3 M ⊙), if present, could reconcile lensing/dynamical and spectroscopic IMF estimates for the SNELLS lenses and account for their lighter M */L relative to the mean matched-σ ETG. We provide the spectra used in this study to facilitate future comparisons.

Precision cosmology with weak gravitational lensing

NASA Astrophysics Data System (ADS)

Hearin, Andrew P.

In recent years, cosmological science has developed a highly predictive model for the universe on large scales that is in quantitative agreement with a wide range of astronomical observations. While the number and diversity of successes of this model provide great confidence that our general picture of cosmology is correct, numerous puzzles remain. In this dissertation, I analyze the potential of planned and near future galaxy surveys to provide new understanding of several unanswered questions in cosmology, and address some of the leading challenges to this observational program. In particular, I study an emerging technique called cosmic shear, the weak gravitational lensing produced by large scale structure. I focus on developing strategies to optimally use the cosmic shear signal observed in galaxy imaging surveys to uncover the physics of dark energy and the early universe. In chapter 1 I give an overview of a few unsolved mysteries in cosmology and I motivate weak lensing as a cosmological probe. I discuss the use of weak lensing as a test of general relativity in chapter 2 and assess the threat to such tests presented by our uncertainty in the physics of galaxy formation. Interpreting the cosmic shear signal requires knowledge of the redshift distribution of the lensed galaxies. This redshift distribution will be significantly uncertain since it must be determined photometrically. In chapter 3 I investigate the influence of photometric redshift errors on our ability to constrain dark energy models with weak lensing. The ability to study dark energy with cosmic shear is also limited by the imprecision in our understanding of the physics of gravitational collapse. In chapter 4 I present the stringent calibration requirements on this source of uncertainty. I study the potential of weak lensing to resolve a debate over a long-standing anomaly in CMB measurements in chapter 5. Finally, in chapter 6 I summarize my findings and conclude with a brief discussion of my

Bacterial adhesion to unworn and worn silicone hydrogel lenses.

PubMed

Vijay, Ajay Kumar; Zhu, Hua; Ozkan, Jerome; Wu, Duojia; Masoudi, Simin; Bandara, Rani; Borazjani, Roya N; Willcox, Mark D P

2012-08-01

The objective of this study was to determine the bacterial adhesion to various silicone hydrogel lens materials and to determine whether lens wear modulated adhesion. Bacterial adhesion (total and viable cells) of Staphylococcus aureus (31, 38, and ATCC 6538) and Pseudomonas aeruginosa (6294, 6206, and GSU-3) to 10 commercially available different unworn and worn silicone hydrogel lenses was measured. Results of adhesion were correlated to polymer and surface properties of contact lenses. S. aureus adhesion to unworn lenses ranged from 2.8 × 10 to 4.4 × 10 colony forming units per lens. The highest adhesion was to lotrafilcon A lenses, and the lowest adhesion was to asmofilcon A lenses. P. aeruginosa adhesion to unworn lenses ranged from 8.9 × 10 to 3.2 × 10 colony forming units per lens. The highest adhesion was to comfilcon A lenses, and the lowest adhesion was to asmofilcon A and balafilcon A lenses. Lens wear altered bacterial adhesion, but the effect was specific to lens and strain type. Adhesion of bacteria, regardless of genera/species or lens wear, was generally correlated with the hydrophobicity of the lens; the less hydrophobic the lens surface, the greater the adhesion. P. aeruginosa adhered in higher numbers to lenses in comparison with S. aureus strains, regardless of the lens type or lens wear. The effect of lens wear was specific to strain and lens. Hydrophobicity of the silicone hydrogel lens surface influenced the adhesion of bacterial cells.

Fimbrolide-coated antimicrobial lenses: their in vitro and in vivo effects.

PubMed

Zhu, Hua; Kumar, Ajay; Ozkan, Jerome; Bandara, Rani; Ding, Aidong; Perera, Indrani; Steinberg, Peter; Kumar, Naresh; Lao, William; Griesser, Stefani S; Britcher, Leanne; Griesser, Hans J; Willcox, Mark D P

2008-05-01

To examine the ability of contact lenses coated with fimbrolides, inhibitors of bacterial quorum sensing, to prevent microbial adhesion and their safety during short-term clinical assessment. A fimbrolide was covalently attached to commercially available high Dk contact lenses. Subsequently Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, or Acanthamoeba sp. were added to the lenses and control uncoated contact lenses. Lenses plus microbes were incubated for 24 h, then washed thoroughly to remove non-adherent microbes. Lenses were macerated and resulting slurry plated onto agar plates. After appropriate incubation, the numbers of colony forming units of bacteria (or numbers of Acanthamoeba trophozoites measured using a hemocytometer) from fimbrolide-coated and uncoated lenses were examined. A Guinea Pig model of lens wear was used to assess the safety of lenses worn on a continuous basis for 1 month. In a separate study, 10 subjects wore fimbrolide-coated lenses for 24 h. The responses of the Guinea Pigs and human volunteers to the lenses were assessed by slit lamp examination. The fimbrolides-coated lenses reduced the adhesion of all bacterial strains tested, with reductions occurring of between 67 and 92%. For Acanthamoeba a reduction of 70% was seen. There were no significant differences in ocular responses to fimbrolide-coated lenses compared with controls in either the 1 month animal model or overnight human trial. Fimbrolide-coated lenses show promise as an antibacterial and anti-acanthamoebal coating on contact lenses and appear to be safe when worn on the eye in an animal model.

Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirk, D.; Omori, Y.; Benoit-Lévy, A.

We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 degmore » $$^{2}$$ of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of $$z_{\\rm med} {\\sim} 0.7$$, while the CMB lensing kernel is broad and peaks at $$z{\\sim}2$$. The resulting cross-correlation is maximally sensitive to mass fluctuations at $$z{\\sim}0.44$$. Assuming the Planck 2015 best-fit cosmology, the amplitude of the DES$$\\times$$SPT cross-power is found to be $$A = 0.88 \\pm 0.30$$ and that from DES$$\\times$$Planck to be $$A = 0.86 \\pm 0.39$$, where $A=1$ corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of $$2.9 \\sigma$$ and $$2.2 \\sigma$$ respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photometric redshift uncertainty and CMB lensing systematics. Significant intrinsic alignment of galaxy shapes would increase the cross-correlation signal inferred from the data; we calculate a value of $$A = 1.08 \\pm 0.36$$ for DES$$\\times$$SPT when we correct the observations with a simple IA model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation, given the size of the statistical uncertainties and the significant impact of systematic errors, particularly IAs. We provide forecasts for the expected signal-to-noise of the combination of the five-year DES survey and SPT-3G.« less

Gravitational lensing in modified Newtonian dynamics

NASA Astrophysics Data System (ADS)

Mortlock, Daniel J.; Turner, Edwin L.

2001-10-01

Modified Newtonian dynamics (MOND) is an alternative theory of gravity that aims to explain large-scale dynamics without recourse to any form of dark matter. However, the theory is incomplete, lacking a relativistic counterpart, and so makes no definite predictions about gravitational lensing. The most obvious form that MONDian lensing might take is that photons experience twice the deflection of massive particles moving at the speed of light, as in general relativity (GR). In such a theory there is no general thin-lens approximation (although one can be made for spherically symmetric deflectors), but the three-dimensional acceleration of photons is in the same direction as the relativistic acceleration would be. In regimes where the deflector can reasonably be approximated as a single point-mass (specifically low-optical depth microlensing and weak galaxy-galaxy lensing), this naive formulation is consistent with observations. Forthcoming galaxy-galaxy lensing data and the possibility of cosmological microlensing have the potential to distinguish unambiguously between GR and MOND. Some tests can also be performed with extended deflectors, for example by using surface brightness measurements of lens galaxies to model quasar lenses, although the breakdown of the thin-lens approximation allows an extra degree of freedom. None the less, it seems unlikely that simple ellipsoidal galaxies can satisfy both constraints. Furthermore, the low-density universe implied by MOND must be completely dominated by the cosmological constant (to fit microwave background observations), and such models are at odds with the low frequency of quasar lenses. These conflicts might be resolved by a fully consistent relativistic extension to MOND; the alternative is that MOND is not an accurate description of the Universe.

Astrophysical Applications of Gravitational Lensing

NASA Astrophysics Data System (ADS)

Mediavilla, Evencio; Muñoz, Jose A.; Garzón, Francisco; Mahoney, Terence J.

2016-10-01

Contributors; Participants; Preface; Acknowledgements; 1. Lensing basics Sherry H. Suyu; 2. Exoplanet microlensing Andrew Gould; 3. Case studies of microlensing Veronica Motta and Emilio Falco; 4. Microlensing of quasars and AGN Joachim Wambsganss; 5. DM in clusters and large-scale structure Peter Schneider; 6. The future of strong lensing Chris Fassnacht; 7. Methods for strong lens modelling Charles Keeton; 8. Tutorial on inverse ray shooting Jorge Jimenez-Vicente.

Effect of cholesterol deposition on bacterial adhesion to contact lenses.

PubMed

Babaei Omali, Negar; Zhu, Hua; Zhao, Zhenjun; Ozkan, Jerome; Xu, Banglao; Borazjani, Roya; Willcox, Mark D P

2011-08-01

To examine the effect of cholesterol on the adhesion of bacteria to silicone hydrogel contact lenses. Contact lenses, collected from subjects wearing Acuvue Oasys or PureVision lenses, were extracted in chloroform:methanol (1:1, v/v) and amount of cholesterol was estimated by thin-layer chromatography. Unworn lenses were soaked in cholesterol, and the numbers of Pseudomonas aeruginosa strains or Staphylococcus aureus strains that adhered to the lenses were measured. Cholesterol was tested for effects on bacterial growth by incubating bacteria in medium containing cholesterol. From ex vivo PureVision lenses, 3.4 ± 0.3 μg/lens cholesterol was recovered, and from Acuvue Oasys lenses, 2.4 ± 0.2 to 1.0 ± 0.1 μg/lens cholesterol was extracted. Cholesterol did not alter the total or viable adhesion of any strain of P. aeruginosa or S. aureus (p > 0.05). However, worn PureVision lenses reduced the numbers of viable cells of P. aeruginosa (5.8 ± 0.4 log units) compared with unworn lenses (6.4 ± 0.2 log units, p = 0.001). Similarly, there were fewer numbers of S. aureus 031 adherent to worn PureVision (3.05 ± 0.8 log units) compared with unworn PureVision (4.6 ± 0.3 log units, p = 0.0001). Worn Acuvue Oasys lenses did not affect bacterial adhesion. Cholesterol showed no effect on the growth of any test strain. Although cholesterol has been shown to adsorb to contact lenses during wear, this lipid does not appear to modulate bacterial adhesion to a lens surface.

The Initial Mass Function in the Nearest Strong Lenses from SNELLS: Assessing the Consistency of Lensing, Dynamical, and Spectroscopic Constraints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newman, Andrew B.; Smith, Russell J.; Conroy, Charlie

2017-08-20

We present new observations of the three nearest early-type galaxy (ETG) strong lenses discovered in the SINFONI Nearby Elliptical Lens Locator Survey (SNELLS). Based on their lensing masses, these ETGs were inferred to have a stellar initial mass function (IMF) consistent with that of the Milky Way, not the bottom-heavy IMF that has been reported as typical for high- σ ETGs based on lensing, dynamical, and stellar population synthesis techniques. We use these unique systems to test the consistency of IMF estimates derived from different methods. We first estimate the stellar M {sub *}/ L using lensing and stellar dynamics.more » We then fit high-quality optical spectra of the lenses using an updated version of the stellar population synthesis models developed by Conroy and van Dokkum. When examined individually, we find good agreement among these methods for one galaxy. The other two galaxies show 2–3 σ tension with lensing estimates, depending on the dark matter contribution, when considering IMFs that extend to 0.08 M {sub ⊙}. Allowing a variable low-mass cutoff or a nonparametric form of the IMF reduces the tension among the IMF estimates to <2 σ . There is moderate evidence for a reduced number of low-mass stars in the SNELLS spectra, but no such evidence in a composite spectrum of matched- σ ETGs drawn from the SDSS. Such variation in the form of the IMF at low stellar masses ( m ≲ 0.3 M {sub ⊙}), if present, could reconcile lensing/dynamical and spectroscopic IMF estimates for the SNELLS lenses and account for their lighter M {sub *}/ L relative to the mean matched- σ ETG. We provide the spectra used in this study to facilitate future comparisons.« less

Stellar Populations of Highly Magnified Lensed Galaxies Young Starburst at Z to Approximately 2

NASA Technical Reports Server (NTRS)

Wuyts, Eva; Rigby, Jane R.; Gladders, Michael D.; Gilbank, David G.; Sharon, Keren; Gralla, Megan B.; Bayliss, Matthew B.

2011-01-01

We present a comprehensive analysis of the rest-frame UV to near-IR spectral energy distributions and rest-frame optical spectra of four of the brightest gravitationally lensed galaxies in the literature: RCSGA 032727-132609 at z = 170, MS1512-cB58 at z = 2.73, SGAS J152745.1+065219 at z = 2.76 and SGAS J12265L3+215220 at z = 2.92. This includes new Spitzer imaging for RCSGA0327 as well as new spectra, near-IR imaging and Spitzer imaging for SGAS1527 and SGAS1226. Lensing magnifications of 3-4 magnitudes allow a detailed study of the stellar populations and physical conditions. We compare star formation rates as measured from the SED fit, the Ha and [O II] .(lambda)3727 emission lines, and the UV+IR bolometric luminosity where 24micron photometry is available. The SFR estimate from the SED fit is consistently higher than the other indicators, which suggests that the Calzetti dust extinction law used in the SED fitting is too flat for young star-forming galaxies at z approx. 2. Our analysis finds similar stellar population parameters for all four lensed galaxies: stellar masses 3 - 7 x 10(exp 9) Stellar mass, young ages approx. 100 Myr, little dust content E(B - V)=0.10-0.25, and star formation rates around 20- 100 Stellar mass/y. Compared to typical values for the galaxy population at z approx. 2, this suggests we are looking at newly formed, starbursting systems that have only recently started the build-up of stellar mass. These results constitute the first detailed, uniform analysis of a sample of the growing number of strongly lensed galaxies known at z approx. 2. Subject headings: galaxies: high-redshift, strong gravitational lensing, infrared: galaxies

Probing supervoids with weak lensing

NASA Astrophysics Data System (ADS)

Higuchi, Yuichi; Inoue, Kaiki Taro

2018-05-01

The cosmic microwave background (CMB) has non-Gaussian features in the temperature fluctuations. An anomalous cold spot surrounded with a hot ring, called the Cold Spot, is one of such features. If a large underdense region (supervoid) resides towards the Cold Spot, we would be able to detect a systematic shape distortion in the images of background source galaxies via weak lensing effect. In order to estimate the detectability of such signals, we used the data of N-body simulations to simulate full-sky ray-tracing of source galaxies. We searched for a most prominent underdense region using the simulated convergence maps smoothed at a scale of 20° and obtained tangential shears around it. The lensing signal expected in a concordant Λ cold dark matter model can be detected at a signal-to-noise ratio S/N ˜ 3. If a supervoid with a radius of ˜200 h-1 Mpc and a density contrast δ0 ˜ -0.3 at the centre resides at a redshift z ˜ 0.2, on-going and near-future weak gravitational lensing surveys would detect a lensing signal with S/N ≳ 4 without resorting to stacking. From the tangential shear profile, we can obtain a constraint on the projected mass distribution of the supervoid.

PICS: SIMULATIONS OF STRONG GRAVITATIONAL LENSING IN GALAXY CLUSTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Nan; Gladders, Michael D.; Florian, Michael K.

2016-09-01

Gravitational lensing has become one of the most powerful tools available for investigating the “dark side” of the universe. Cosmological strong gravitational lensing, in particular, probes the properties of the dense cores of dark matter halos over decades in mass and offers the opportunity to study the distant universe at flux levels and spatial resolutions otherwise unavailable. Studies of strongly lensed variable sources offer even further scientific opportunities. One of the challenges in realizing the potential of strong lensing is to understand the statistical context of both the individual systems that receive extensive follow-up study, as well as that ofmore » the larger samples of strong lenses that are now emerging from survey efforts. Motivated by these challenges, we have developed an image simulation pipeline, Pipeline for Images of Cosmological Strong lensing (PICS), to generate realistic strong gravitational lensing signals from group- and cluster-scale lenses. PICS uses a low-noise and unbiased density estimator based on (resampled) Delaunay Tessellations to calculate the density field; lensed images are produced by ray-tracing images of actual galaxies from deep Hubble Space Telescope observations. Other galaxies, similarly sampled, are added to fill in the light cone. The pipeline further adds cluster member galaxies and foreground stars into the lensed images. The entire image ensemble is then observed using a realistic point-spread function that includes appropriate detector artifacts for bright stars. Noise is further added, including such non-Gaussian elements as noise window-paning from mosaiced observations, residual bad pixels, and cosmic rays. The aim is to produce simulated images that appear identical—to the eye (expert or otherwise)—to real observations in various imaging surveys.« less

PICS: SIMULATIONS OF STRONG GRAVITATIONAL LENSING IN GALAXY CLUSTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Nan; Gladders, Michael D.; Rangel, Esteban M.

2016-08-29

Gravitational lensing has become one of the most powerful tools available for investigating the “dark side” of the universe. Cosmological strong gravitational lensing, in particular, probes the properties of the dense cores of dark matter halos over decades in mass and offers the opportunity to study the distant universe at flux levels and spatial resolutions otherwise unavailable. Studies of strongly lensed variable sources offer even further scientific opportunities. One of the challenges in realizing the potential of strong lensing is to understand the statistical context of both the individual systems that receive extensive follow-up study, as well as that ofmore » the larger samples of strong lenses that are now emerging from survey efforts. Motivated by these challenges, we have developed an image simulation pipeline, Pipeline for Images of Cosmological Strong lensing (PICS), to generate realistic strong gravitational lensing signals from group- and cluster-scale lenses. PICS uses a low-noise and unbiased density estimator based on (resampled) Delaunay Tessellations to calculate the density field; lensed images are produced by ray-tracing images of actual galaxies from deep Hubble Space Telescope observations. Other galaxies, similarly sampled, are added to fill in the light cone. The pipeline further adds cluster member galaxies and foreground stars into the lensed images. The entire image ensemble is then observed using a realistic point-spread function that includes appropriate detector artifacts for bright stars. Noise is further added, including such non-Gaussian elements as noise window-paning from mosaiced observations, residual bad pixels, and cosmic rays. The aim is to produce simulated images that appear identical—to the eye (expert or otherwise)—to real observations in various imaging surveys.« less

Finding strong lenses in CFHTLS using convolutional neural networks

NASA Astrophysics Data System (ADS)

Jacobs, C.; Glazebrook, K.; Collett, T.; More, A.; McCarthy, C.

2017-10-01

We train and apply convolutional neural networks, a machine learning technique developed to learn from and classify image data, to Canada-France-Hawaii Telescope Legacy Survey (CFHTLS) imaging for the identification of potential strong lensing systems. An ensemble of four convolutional neural networks was trained on images of simulated galaxy-galaxy lenses. The training sets consisted of a total of 62 406 simulated lenses and 64 673 non-lens negative examples generated with two different methodologies. An ensemble of trained networks was applied to all of the 171 deg2 of the CFHTLS wide field image data, identifying 18 861 candidates including 63 known and 139 other potential lens candidates. A second search of 1.4 million early-type galaxies selected from the survey catalogue as potential deflectors, identified 2465 candidates including 117 previously known lens candidates, 29 confirmed lenses/high-quality lens candidates, 266 novel probable or potential lenses and 2097 candidates we classify as false positives. For the catalogue-based search we estimate a completeness of 21-28 per cent with respect to detectable lenses and a purity of 15 per cent, with a false-positive rate of 1 in 671 images tested. We predict a human astronomer reviewing candidates produced by the system would identify 20 probable lenses and 100 possible lenses per hour in a sample selected by the robot. Convolutional neural networks are therefore a promising tool for use in the search for lenses in current and forthcoming surveys such as the Dark Energy Survey and the Large Synoptic Survey Telescope.

Quantitative evaluation of performance of three-dimensional printed lenses

NASA Astrophysics Data System (ADS)

Gawedzinski, John; Pawlowski, Michal E.; Tkaczyk, Tomasz S.

2017-08-01

We present an analysis of the shape, surface quality, and imaging capabilities of custom three-dimensional (3-D) printed lenses. 3-D printing technology enables lens prototypes to be fabricated without restrictions on surface geometry. Thus, spherical, aspherical, and rotationally nonsymmetric lenses can be manufactured in an integrated production process. This technique serves as a noteworthy alternative to multistage, labor-intensive, abrasive processes, such as grinding, polishing, and diamond turning. Here, we evaluate the quality of lenses fabricated by Luxexcel using patented Printoptical©; technology that is based on an inkjet printing technique by comparing them to lenses made with traditional glass processing technologies (grinding, polishing, etc.). The surface geometry and roughness of the lenses were evaluated using white-light and Fizeau interferometers. We have compared peak-to-valley wavefront deviation, root mean square (RMS) wavefront error, radii of curvature, and the arithmetic roughness average (Ra) profile of plastic and glass lenses. In addition, the imaging performance of selected pairs of lenses was tested using 1951 USAF resolution target. The results indicate performance of 3-D printed optics that could be manufactured with surface roughness comparable to that of injection molded lenses (Ra<20 nm). The RMS wavefront error of 3-D printed prototypes was at a minimum 18.8 times larger than equivalent glass prototypes for a lens with a 12.7 mm clear aperture, but, when measured within 63% of its clear aperture, the 3-D printed components' RMS wavefront error was comparable to glass lenses.

Quantitative evaluation of performance of 3D printed lenses

PubMed Central

Gawedzinski, John; Pawlowski, Michal E.; Tkaczyk, Tomasz S.

2017-01-01

We present an analysis of the shape, surface quality, and imaging capabilities of custom 3D printed lenses. 3D printing technology enables lens prototypes to be fabricated without restrictions on surface geometry. Thus, spherical, aspherical and rotationally non-symmetric lenses can be manufactured in an integrated production process. This technique serves as a noteworthy alternative to multistage, labor-intensive, abrasive processes such as grinding, polishing and diamond turning. Here, we evaluate the quality of lenses fabricated by Luxexcel using patented Printoptical© technology that is based on an inkjet printing technique by comparing them to lenses made with traditional glass processing technologies (grinding, polishing etc.). The surface geometry and roughness of the lenses were evaluated using white-light and Fizeau interferometers. We have compared peak-to-valley wavefront deviation, root-mean-squared wavefront error, radii of curvature and the arithmetic average of the roughness profile (Ra) of plastic and glass lenses. Additionally, the imaging performance of selected pairs of lenses was tested using 1951 USAF resolution target. The results indicate performance of 3D printed optics that could be manufactured with surface roughness comparable to that of injection molded lenses (Ra < 20 nm). The RMS wavefront error of 3D printed prototypes was at a minimum 18.8 times larger than equivalent glass prototypes for a lens with a 12.7 mm clear aperture, but when measured within 63% of its clear aperture, 3D printed components’ RMS wavefront error was comparable to glass lenses. PMID:29238114

Line-of-sight structure toward strong lensing galaxy clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayliss, Matthew B.; Johnson, Traci; Sharon, Keren

2014-03-01

We present an analysis of the line-of-sight structure toward a sample of 10 strong lensing cluster cores. Structure is traced by groups that are identified spectroscopically in the redshift range, 0.1 ≤ z ≤ 0.9, and we measure the projected angular and comoving separations between each group and the primary strong lensing clusters in each corresponding line of sight. From these data we measure the distribution of projected angular separations between the primary strong lensing clusters and uncorrelated large-scale structure as traced by groups. We then compare the observed distribution of angular separations for our strong lensing selected lines ofmore » sight against the distribution of groups that is predicted for clusters lying along random lines of sight. There is clear evidence for an excess of structure along the line of sight at small angular separations (θ ≤ 6') along the strong lensing selected lines of sight, indicating that uncorrelated structure is a significant systematic that contributes to producing galaxy clusters with large cross sections for strong lensing. The prevalence of line-of-sight structure is one of several biases in strong lensing clusters that can potentially be folded into cosmological measurements using galaxy cluster samples. These results also have implications for current and future studies—such as the Hubble Space Telescope Frontier Fields—that make use of massive galaxy cluster lenses as precision cosmological telescopes; it is essential that the contribution of line-of-sight structure be carefully accounted for in the strong lens modeling of the cluster lenses.« less

Using Strong Gravitational Lensing to Identify Fossil Group Progenitors

NASA Astrophysics Data System (ADS)

Johnson, Lucas E.; Irwin, Jimmy A.; White, Raymond E., III; Wong, Ka-Wah; Maksym, W. Peter; Dupke, Renato A.; Miller, Eric D.; Carrasco, Eleazar R.

2018-04-01

Fossil galaxy systems are classically thought to be the end result of galaxy group/cluster evolution, as galaxies experiencing dynamical friction sink to the center of the group potential and merge into a single, giant elliptical that dominates the rest of the members in both mass and luminosity. Most fossil systems discovered lie within z < 0.2, which leads to the question, what were these systems’ progenitors? Such progenitors are expected to have imminent or ongoing major merging near the brightest group galaxy that, when concluded, will meet the fossil criteria within the look forward time. Since strong gravitational lensing preferentially selects groups merging along the line of sight, or systems with a high mass concentration like fossil systems, we searched the CASSOWARY survey of strong-lensing events with the goal of determining whether lensing systems have any predisposition to being fossil systems or progenitors. We find that ∼13% of lensing groups are identified as traditional fossils while only ∼3% of nonlensing control groups are. We also find that ∼23% of lensing systems are traditional fossil progenitors compared to ∼17% for the control sample. Our findings show that strong-lensing systems are more likely to be fossil/pre-fossil systems than comparable nonlensing systems. Cumulative galaxy luminosity functions of the lensing and nonlensing groups also indicate a possible, fundamental difference between strong-lensing and nonlensing systems’ galaxy populations, with lensing systems housing a greater number of bright galaxies even in the outskirts of groups.

Probabilistic Cosmological Mass Mapping from Weak Lensing Shear

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, M. D.; Dawson, W. A.; Ng, K. Y.

2017-04-10

We infer gravitational lensing shear and convergence fields from galaxy ellipticity catalogs under a spatial process prior for the lensing potential. We demonstrate the performance of our algorithm with simulated Gaussian-distributed cosmological lensing shear maps and a reconstruction of the mass distribution of the merging galaxy cluster Abell 781 using galaxy ellipticities measured with the Deep Lens Survey. Given interim posterior samples of lensing shear or convergence fields on the sky, we describe an algorithm to infer cosmological parameters via lens field marginalization. In the most general formulation of our algorithm we make no assumptions about weak shear or Gaussian-distributedmore » shape noise or shears. Because we require solutions and matrix determinants of a linear system of dimension that scales with the number of galaxies, we expect our algorithm to require parallel high-performance computing resources for application to ongoing wide field lensing surveys.« less

Probabilistic cosmological mass mapping from weak lensing shear

DOE PAGES

Schneider, M. D.; Ng, K. Y.; Dawson, W. A.; ...

2017-04-10

Here, we infer gravitational lensing shear and convergence fields from galaxy ellipticity catalogs under a spatial process prior for the lensing potential. We demonstrate the performance of our algorithm with simulated Gaussian-distributed cosmological lensing shear maps and a reconstruction of the mass distribution of the merging galaxy cluster Abell 781 using galaxy ellipticities measured with the Deep Lens Survey. Given interim posterior samples of lensing shear or convergence fields on the sky, we describe an algorithm to infer cosmological parameters via lens field marginalization. In the most general formulation of our algorithm we make no assumptions about weak shear ormore » Gaussian-distributed shape noise or shears. Because we require solutions and matrix determinants of a linear system of dimension that scales with the number of galaxies, we expect our algorithm to require parallel high-performance computing resources for application to ongoing wide field lensing surveys.« less

Zoom microscope objective using electrowetting lenses.

PubMed

Li, Lei; Wang, Di; Liu, Chao; Wang, Qiong-Hua

2016-02-08

We report a zoom microscope objective which can achieve continuous zoom change and correct the aberrations dynamically. The objective consists of three electrowetting liquid lenses and two glass lenses. The magnification is changed by applying voltages on the three electrowetting lenses. Besides, the three electrowetting liquid lenses can play a role to correct the aberrations. A digital microscope based on the proposed objective is demonstrated. We analyzed the properties of the proposed objective. In contrast to the conventional objectives, the proposed objective can be tuned from ~7.8 × to ~13.2 × continuously. For our objective, the working distance is fixed, which means no movement parts are needed to refocus or change its magnification. Moreover, the zoom objective can be dynamically optimized for a wide range of wavelength. Using such an objective, the fabrication tolerance of the optical system is larger than that of a conventional system, which can decrease the fabrication cost. The proposed zoom microscope objective cannot only take place of the conventional objective, but also has potential application in the 3D microscopy.

Cosmological test using strong gravitational lensing systems

NASA Astrophysics Data System (ADS)

Yuan, C. C.; Wang, F. Y.

2015-09-01

As one of the probes of universe, strong gravitational lensing systems allow us to compare different cosmological models and constrain vital cosmological parameters. This purpose can be reached from the dynamic and geometry properties of strong gravitational lensing systems, for instance, time-delay Δτ of images, the velocity dispersion σ of the lensing galaxies and the combination of these two effects, Δτ/σ2. In this paper, in order to carry out one-on-one comparisons between ΛCDM universe and Rh = ct universe, we use a sample containing 36 strong lensing systems with the measurement of velocity dispersion from the Sloan Lens Advanced Camera for Surveys (SLACS) and Lens Structure and Dynamic survey (LSD) survey. Concerning the time-delay effect, 12 two-image lensing systems with Δτ are also used. In addition, Monte Carlo simulations are used to compare the efficiency of the three methods as mentioned above. From simulations, we estimate the number of lenses required to rule out one model at the 99.7 per cent confidence level. Comparing with constraints from Δτ and the velocity dispersion σ, we find that using Δτ/σ2 can improve the discrimination between cosmological models. Despite the independence tests of these methods reveal a correlation between Δτ/σ2 and σ, Δτ/σ2 could be considered as an improved method of σ if more data samples are available.

Lensing as a probe of early universe: from CMB to galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hassani, Farbod; Baghram, Shant; Firouzjahi, Hassan, E-mail: farbod@physics.sharif.edu, E-mail: baghram@sharif.edu, E-mail: firouz@ipm.ir

The Cosmic Microwave Background (CMB) radiation lensing is a promising tool to study the physics of early universe. In this work we probe the imprints of deviations from isotropy and scale invariance of primordial curvature perturbation power spectrum on CMB lensing potential and convergence. Specifically, we consider a scale-dependent hemispherical asymmetry in primordial power spectrum. We show that the CMB lensing potential and convergence and also the cross-correlation of the CMB lensing and late time galaxy convergence can probe the amplitude and the scale dependence of the dipole modulation. As another example, we consider a primordial power spectrum with localmore » feature. We show that the CMB lensing and the cross-correlation of the CMB lensing and galaxy lensing can probe the amplitude and the shape of the local feature. We show that the cross correlation of CMB lensing convergence and galaxy lensing is capable to probe the effects of local features in power spectrum on smaller scales than the CMB lensing. Finally we showed that the current data can constrain the amplitude and moment dependence of dipole asymmetry.« less

Paraboloid-aspheric lenses free of spherical aberration

NASA Astrophysics Data System (ADS)

Lozano-Rincón, Ninfa del C.; Valencia-Estrada, Juan Camilo

2017-07-01

A method to design singlet paraboloid-aspheric lenses free of all orders of spherical aberration with maximum aperture is described. This work includes all parametric formulas to describe paraboloid-aspheric or aspheric-paraboloid lenses for any finite conjugated planes. It also includes the Schwarzchilds approximations (which can be used to calculate one rigorous propagation of light waves in physic optics) to design convex paraboloid-aspheric lenses for imaging an object at infinity, with explicit formulas to calculate thicknesses easily. The results were verified with software through ray tracing.

X-Ray Properties of Lensing-Selected Clusters

NASA Astrophysics Data System (ADS)

Paterno-Mahler, Rachel; Sharon, Keren; Bayliss, Matthew; McDonald, Michael; Gladders, Michael; Johnson, Traci; Dahle, Hakon; Rigby, Jane R.; Whitaker, Katherine E.; Florian, Michael; Wuyts, Eva

2017-08-01

I will present preliminary results from the Michigan Swift X-ray observations of clusters from the Sloan Giant Arcs Survey (SGAS). These clusters were lensing selected based on the presence of a giant arc visible from SDSS. I will characterize the morphology of the intracluster medium (ICM) of the clusters in the sample, and discuss the offset between the X-ray centroid, the mass centroid as determined by strong lensing analysis, and the BCG position. I will also present early-stage work on the scaling relation between the lensing mass and the X-ray luminosity.

Weak Gravitational Lensing by the Nearby Cluster Abell 3667.

PubMed

Joffre; Fischer; Frieman; McKay; Mohr; Nichol; Johnston; Sheldon; Bernstein

2000-05-10

We present two weak lensing reconstructions of the nearby (zcl=0.055) merging cluster Abell 3667, based on observations taken approximately 1 yr apart under different seeing conditions. This is the lowest redshift cluster with a weak lensing mass reconstruction to date. The reproducibility of features in the two mass maps demonstrates that weak lensing studies of low-redshift clusters are feasible. These data constitute the first results from an X-ray luminosity-selected weak lensing survey of 19 low-redshift (z<0.1) southern clusters.

Constraints on cosmological models from strong gravitational lensing systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cao, Shuo; Pan, Yu; Zhu, Zong-Hong

Strong lensing has developed into an important astrophysical tool for probing both cosmology and galaxies (their structure, formation, and evolution). Using the gravitational lensing theory and cluster mass distribution model, we try to collect a relatively complete observational data concerning the Hubble constant independent ratio between two angular diameter distances D{sub ds}/D{sub s} from various large systematic gravitational lens surveys and lensing by galaxy clusters combined with X-ray observations, and check the possibility to use it in the future as complementary to other cosmological probes. On one hand, strongly gravitationally lensed quasar-galaxy systems create such a new opportunity by combiningmore » stellar kinematics (central velocity dispersion measurements) with lensing geometry (Einstein radius determination from position of images). We apply such a method to a combined gravitational lens data set including 70 data points from Sloan Lens ACS (SLACS) and Lens Structure and Dynamics survey (LSD). On the other hand, a new sample of 10 lensing galaxy clusters with redshifts ranging from 0.1 to 0.6 carefully selected from strong gravitational lensing systems with both X-ray satellite observations and optical giant luminous arcs, is also used to constrain three dark energy models (ΛCDM, constant w and CPL) under a flat universe assumption. For the full sample (n = 80) and the restricted sample (n = 46) including 36 two-image lenses and 10 strong lensing arcs, we obtain relatively good fitting values of basic cosmological parameters, which generally agree with the results already known in the literature. This results encourages further development of this method and its use on larger samples obtained in the future.« less

Exciting discoveries of strong gravitational lenses from the HSC Survey

NASA Astrophysics Data System (ADS)

More, Anupreeta; Team 1: Masayuki Tanaka, Kenneth Wong, et al.; Team 2: Chien-Hsiu Lee, Masamune Oguri, et al.

2017-01-01

Strong gravitational lenses have numerous applications in astrophysics and cosmology. We expect to discover thousands of strong gravitational lenses from the Hyper Suprime-Cam (HSC) Survey, thanks to its unique combination of deep and wide imaging. I will give highlights on a few interesting gravitational lenses that were discovered recently from early HSC data, for example, the first spectroscopically confirmed double source plane (DSP) lens system dubbed ''Eye of Horus'' and the highest-redshift quadruply-lensed low-luminosity Active Galactic Nucleus (LLAGN).DSP lenses such as ''Eye of Horus'' are even more rare than ordinary lenses but provide tighter constraints on the lens mass distribution and can also be useful to measure cosmological parameters such as Dark Energy and Matter density parameter. The lensed LLAGN discovered recently from HSC is only the second such lens system in our knowledge. LLAGNs are thought to have differentmechanisms driving their nuclear activity compared to their brighter counterparts i.e. quasars. Our knowledge about this abundant but faint population of AGNs is limited to the local universe so far. But lensing magnification will allow studies of distant LLAGNs which should be discovered in large numbers from a deep survey like HSC for the first time. Also, owing to the variable nature of LLAGNs, they could potentially be used as a cosmological probe similar to the lensed quasars.

Plasma surface modification of rigid contact lenses decreases bacterial adhesion.

PubMed

Wang, Yingming; Qian, Xuefeng; Zhang, Xiaofeng; Xia, Wei; Zhong, Lei; Sun, Zhengtai; Xia, Jing

2013-11-01

Contact lens safety is an important topic in clinical studies. Corneal infections usually occur because of the use of bacteria-carrying contact lenses. The current study investigated the impact of plasma surface modification on bacterial adherence to rigid contact lenses made of fluorosilicone acrylate materials. Boston XO and XO2 contact lenses were modified using plasma technology (XO-P and XO2-P groups). Untreated lenses were used as controls. Plasma-treated and control lenses were incubated in solutions containing Staphylococcus aureus or Pseudomonas aeruginosa. MTT colorimetry, colony-forming unit counting method, and scanning electron microscopy were used to measure bacterial adhesion. MTT colorimetry measurements showed that the optical density (OD) values of XO-P and XO2-P were significantly lower than those of XO and XO2, respectively, after incubation with S. aureus (P < 0.01). The OD value of XO-P was also much lower than that of XO after incubation with P. aeruginosa (P < 0.01). Colony-forming unit counting revealed that a significantly lower number of bacterial colonies attached to the XO-P versus XO lenses and to the XO2-P versus XO2 lenses incubated with S. aureus (P < 0.01). Fewer bacterial colonies attached to the XO-P versus XO lenses incubated with P. aeruginosa (P < 0.01). Further, scanning electron microscopy suggested different bacterial adhesion morphology on plasma-treated versus control lenses. Plasma surface modification can significantly decrease bacterial adhesion to fluorosilicone acrylate contact lenses. This study provides important evidence of a unique benefit of plasma technology in contact lens surface modification.

Visual performance with sport-tinted contact lenses in natural sunlight.

PubMed

Erickson, Graham B; Horn, Fraser C; Barney, Tyler; Pexton, Brett; Baird, Richard Y

2009-05-01

The use of tinted and clear contact lenses (CLs) in all aspects of life is becoming a more popular occurrence, particularly in athletic activities. This study broadens previous research regarding performance-tinted CLs and their effects on measures of visual performance. Thirty-three subjects (14 male, 19 female) were fitted with clear B&L Optima 38, 50% visible light transmission Amber and 36% visible light transmission Gray-Green Nike Maxsight CLs in an individualized randomized sequence. Subjects were dark-adapted with welding goggles before testing and in between subtests involving a Bailey-Lovie chart and the Haynes Distance Rock test. The sequence of testing was repeated for each lens modality. The Amber and Gray-Green lenses enabled subjects to recover vision faster in bright sunlight compared with clear lenses. Also, subjects were able to achieve better visual recognition in bright sunlight when compared with clear lenses. Additionally, the lenses allowed the subjects to alternate fixation between a bright and shaded target at a more rapid rate in bright sunlight as compared with clear lenses. Subjects preferred both the Amber and Gray-Green lenses over clear lenses in the bright and shadowed target conditions. The results of the current study show that Maxsight Amber and Gray-Green lenses provide better contrast discrimination in bright sunlight, better contrast discrimination when alternating between bright and shaded target conditions, better speed of visual recovery in bright sunlight, and better overall visual performance in bright and shaded target conditions compared with clear lenses.

Jet printing of convex and concave polymer micro-lenses.

PubMed

Blattmann, M; Ocker, M; Zappe, H; Seifert, A

2015-09-21

We describe a novel approach for fabricating customized convex as well as concave micro-lenses using substrates with sophisticated pinning architecture and utilizing a drop-on-demand jet printer. The polymeric lens material deposited on the wafer is cured by UV light irradiation yielding lenses with high quality surfaces. Surface shape and roughness of the cured polymer lenses are characterized by white light interferometry. Their optical quality is demonstrated by imaging an USAF1951 test chart. The evaluated modulation transfer function is compared to Zemax simulations as a benchmark for the fabricated lenses.

Light scatter on the surface of AcrySof intraocular lenses: part I. Analysis of lenses retrieved from pseudophakic postmortem human eyes.

PubMed

Yaguchi, Shigeo; Nishihara, Hitoshi; Kambhiranond, Waraporn; Stanley, Daniel; Apple, David J

2008-01-01

To investigate the cause of light scatter measured on the surface of AcrySof intraocular lenses (Alcon Laboratories, Inc., Fort Worth, TX) retrieved from pseudophakic postmortem human eyes. Ten intraocular lenses (Alcon AcrySofModel MA60BM) were retrieved postmortem and analyzed for light scatter before and after removal of surface-bound biofilms. Six of the 10 lenses exhibited light scatter that was clearly above baseline levels. In these 6 lenses, both peak and average pixel density were reduced by approximately 80% after surface cleaning. The current study demonstrates that a coating deposited in vivo on the lens surface is responsible for the light scatter observed when incident light is applied.

A gravitationally lensed quasar discovered in OGLE

NASA Astrophysics Data System (ADS)

Kostrzewa-Rutkowska, Zuzanna; Kozłowski, Szymon; Lemon, Cameron; Anguita, T.; Greiner, J.; Auger, M. W.; Wyrzykowski, Ł.; Apostolovski, Y.; Bolmer, J.; Udalski, A.; Szymański, M. K.; Soszyński, I.; Poleski, R.; Pietrukowicz, P.; Skowron, J.; Mróz, P.; Ulaczyk, K.; Pawlak, M.

2018-05-01

We report the discovery of a new gravitationally lensed quasar (double) from the Optical Gravitational Lensing Experiment (OGLE) identified inside the ˜670deg2 area encompassing the Magellanic Clouds. The source was selected as one of ˜60 `red W1 - W2' mid-infrared objects from WISE and having a significant amount of variability in OGLE for both two (or more) nearby sources. This is the first detection of a gravitational lens, where the discovery is made `the other way around', meaning we first measured the time delay between the two lensed quasar images of -132 < tAB < -76 d (90 per cent CL), with the median tAB ≈ -102 d (in the observer frame), and where the fainter image B lags image A. The system consists of the two quasar images separated by 1.5 arcsec on the sky, with I ≈ 20.0 mag and I ≈ 19.6 mag, respectively, and a lensing galaxy that becomes detectable as I ≈ 21.5 mag source, 1.0 arcsec from image A, after subtracting the two lensed images. Both quasar images show clear AGN broad emission lines at z = 2.16 in the New Technology Telescope spectra. The spectral energy distribution (SED) fitting with the fixed source redshift provided the estimate of the lensing galaxy redshift of z ≈ 0.9 ± 0.2 (90 per cent CL), while its type is more likely to be elliptical (the SED-inferred and lens-model stellar mass is more likely present in ellipticals) than spiral (preferred redshift by the lens model).

Effect of Masked Regions on Weak-lensing Statistics

NASA Astrophysics Data System (ADS)

Shirasaki, Masato; Yoshida, Naoki; Hamana, Takashi

2013-09-01

Sky masking is unavoidable in wide-field weak-lensing observations. We study how masks affect the measurement of statistics of matter distribution probed by weak gravitational lensing. We first use 1000 cosmological ray-tracing simulations to examine in detail the impact of masked regions on the weak-lensing Minkowski Functionals (MFs). We consider actual sky masks used for a Subaru Suprime-Cam imaging survey. The masks increase the variance of the convergence field and the expected values of the MFs are biased. The bias then compromises the non-Gaussian signals induced by the gravitational growth of structure. We then explore how masks affect cosmological parameter estimation. We calculate the cumulative signal-to-noise ratio (S/N) for masked maps to study the information content of lensing MFs. We show that the degradation of S/N for masked maps is mainly determined by the effective survey area. We also perform simple χ2 analysis to show the impact of lensing MF bias due to masked regions. Finally, we compare ray-tracing simulations with data from a Subaru 2 deg2 survey in order to address if the observed lensing MFs are consistent with those of the standard cosmology. The resulting χ2/n dof = 29.6/30 for three combined MFs, obtained with the mask effects taken into account, suggests that the observational data are indeed consistent with the standard ΛCDM model. We conclude that the lensing MFs are a powerful probe of cosmology only if mask effects are correctly taken into account.

EFFECT OF MASKED REGIONS ON WEAK-LENSING STATISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shirasaki, Masato; Yoshida, Naoki; Hamana, Takashi, E-mail: masato.shirasaki@utap.phys.s.u-tokyo.ac.jp

2013-09-10

Sky masking is unavoidable in wide-field weak-lensing observations. We study how masks affect the measurement of statistics of matter distribution probed by weak gravitational lensing. We first use 1000 cosmological ray-tracing simulations to examine in detail the impact of masked regions on the weak-lensing Minkowski Functionals (MFs). We consider actual sky masks used for a Subaru Suprime-Cam imaging survey. The masks increase the variance of the convergence field and the expected values of the MFs are biased. The bias then compromises the non-Gaussian signals induced by the gravitational growth of structure. We then explore how masks affect cosmological parameter estimation.more » We calculate the cumulative signal-to-noise ratio (S/N) for masked maps to study the information content of lensing MFs. We show that the degradation of S/N for masked maps is mainly determined by the effective survey area. We also perform simple {chi}{sup 2} analysis to show the impact of lensing MF bias due to masked regions. Finally, we compare ray-tracing simulations with data from a Subaru 2 deg{sup 2} survey in order to address if the observed lensing MFs are consistent with those of the standard cosmology. The resulting {chi}{sup 2}/n{sub dof} = 29.6/30 for three combined MFs, obtained with the mask effects taken into account, suggests that the observational data are indeed consistent with the standard {Lambda}CDM model. We conclude that the lensing MFs are a powerful probe of cosmology only if mask effects are correctly taken into account.« less

Functionalized patchy particles using colloidal lenses

NASA Astrophysics Data System (ADS)

Middleton, Christine

2014-03-01

Colloidal assembly had been limited by the isotropic, nonspecific nature of interactions between spherical colloidal particles. By giving particles patches functionalized with single stranded DNA, these interactions can be made both directional and specific. We create patchy particles by adding patches to spherical emulsion droplets using the depletion interaction. First we make polystyrene particles in the shape of contact lenses to be the patches. The lenses are functionalized with single stranded DNA on their convex side. Then we put the lenses on the surface of oil emulsion droplets using the depletion interaction, creating a patch (or multiple patches) on the surface of each emulsion droplet. The emulsion droplets can now interact with each other in a specific, directional way through DNA functionalized patches.

Gravitational Lensing from a Spacetime Perspective.

PubMed

Perlick, Volker

2004-01-01

The theory of gravitational lensing is reviewed from a spacetime perspective, without quasi-Newtonian approximations. More precisely, the review covers all aspects of gravitational lensing where light propagation is described in terms of lightlike geodesics of a metric of Lorentzian signature. It includes the basic equations and the relevant techniques for calculating the position, the shape, and the brightness of images in an arbitrary general-relativistic spacetime. It also includes general theorems on the classification of caustics, on criteria for multiple imaging, and on the possible number of images. The general results are illustrated with examples of spacetimes where the lensing features can be explicitly calculated, including the Schwarzschild spacetime, the Kerr spacetime, the spacetime of a straight string, plane gravitational waves, and others.

THE CLUSTER LENSING AND SUPERNOVA SURVEY WITH HUBBLE (CLASH): STRONG-LENSING ANALYSIS OF A383 FROM 16-BAND HST/WFC3/ACS IMAGING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zitrin, A.; Broadhurst, T.; Coe, D.

2011-12-01

We examine the inner mass distribution of the relaxed galaxy cluster A383 (z = 0.189), in deep 16 band Hubble Space Telescope/ACS+WFC3 imaging taken as part of the Cluster Lensing And Supernova survey with Hubble (CLASH) multi-cycle treasury program. Our program is designed to study the dark matter distribution in 25 massive clusters, and balances depth with a wide wavelength coverage, 2000-16000 A, to better identify lensed systems and generate precise photometric redshifts. This photometric information together with the predictive strength of our strong-lensing analysis method identifies 13 new multiply lensed images and candidates, so that a total of 27more » multiple images of nine systems are used to tightly constrain the inner mass profile gradient, dlog {Sigma}/dlog r {approx_equal} -0.6 {+-} 0.1 (r < 160 kpc). We find consistency with the standard distance-redshift relation for the full range spanned by the lensed images, 1.01 < z < 6.03, with the higher-redshift sources deflected through larger angles as expected. The inner mass profile derived here is consistent with the results of our independent weak-lensing analysis of wide-field Subaru images, with good agreement in the region of overlap ({approx}0.7-1 arcmin). Combining weak and strong lensing, the overall mass profile is well fitted by a Navarro-Frenk-White profile with M{sub vir} = (5.37{sup +0.70}{sub -0.63} {+-} 0.26) Multiplication-Sign 10{sup 14} M{sub Sun} h{sup -1} and a relatively high concentration, c{sub vir} = 8.77{sup +0.44}{sub -0.42} {+-} 0.23, which lies above the standard c-M relation similar to other well-studied clusters. The critical radius of A383 is modest by the standards of other lensing clusters, r{sub E} {approx_equal} 16 {+-} 2'' (for z{sub s} = 2.55), so the relatively large number of lensed images uncovered here with precise photometric redshifts validates our imaging strategy for the CLASH survey. In total we aim to provide similarly high-quality lensing data for 25

Spectroscopic Observations of the Outflowing Wind in the Lensed Quasar SDSS J1001+5027

NASA Astrophysics Data System (ADS)

Misawa, Toru; Inada, Naohisa; Oguri, Masamune; Charlton, Jane C.; Eracleous, Michael; Koyamada, Suzuka; Itoh, Daisuke

2018-02-01

We performed spectroscopic observations of the small-separation lensed quasar SDSS J1001+5027, whose images have an angular separation θ =2\\buildrel{\\prime\\prime}\\over{.} 86, and placed constraints on the physical properties of gas clouds in the vicinity of the quasar (i.e., in the outflowing wind launched from the accretion disk). The two cylinders of sight to the two lensed images go through the same region of the outflowing wind and they become fully separated with no overlap at a very large distance from the source (∼330 pc). We discovered a clear difference in the profile of the C IV broad absorption line (BAL) detected in the two lensed images in two observing epochs. Because the kinematic components in the BAL profile do not vary in concert, the observed variations cannot be reproduced by a simple change of ionization state. If the variability is due to gas motion around the background source (i.e., the continuum source), the corresponding rotational velocity is {v}rot} ≥ 18,000 km s‑1, and their distance from the source is r≤slant 0.06 pc assuming Keplerian motion. Among three Mg II and three C IV NAL systems that we detected in the spectra, only the Mg II system at {z}abs} = 0.8716 shows a hint of variability in its Mg I profile on a rest-frame timescale of {{Δ }}{t}rest} ≤slant 191 days and an obvious velocity shear between the sightlines whose physical separation is ∼7 kpc. We interpret this as the result of motion of a cosmologically intervening absorber, perhaps located in a foreground galaxy. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

Multiple use of aspheres in cine lenses

NASA Astrophysics Data System (ADS)

Beder, Christian; Gängler, Dietmar

2008-09-01

Today's high performance cine lenses rely more and more on the use of aspheres. These are as powerful in correcting aberrations as they are expensive if it is not possible to use high-volume manufacturing processes. One possible solution to meet the increasing demands of design to cost is the use of identical parts in several lenses. The biggest gain is possible with the most expensive parts: the aspheres. In this presentation a successful as well as an ineffective way of incorporating the same asphere in three lenses which differ by a factor of 1.5 in focal length will be shown.

Thin Film Coating Technology For Ophthalmic Lenses

NASA Astrophysics Data System (ADS)

Guenther, K. H.

1986-05-01

Coating of ophthalmic lenses is an application of high-vacuum coating technology which must satisfy not only physical and technical requirements but also customer demands with respect to aesthetics, color fidelity, and exchangeability of coated ophthalmic lenses. Because this application caters specifically to the consumer market, ophthalmic lenses are subject to certain fashion trends which frequently require quick adaptation of the coating technique. The state-of-the-art of ophthalmic lens coating is reviewed in this paper, with particular emphasis on the durability requirements in daily use by untrained consumers as well as on the applicable testing methods.

Scleral contact lenses for the management of complicated ptosis.

PubMed

Katsoulos, Konstantinos; Rallatos, Gerasimos Livir; Mavrikakis, Ioannis

2018-06-01

To present the management of three patients suffering from ptosis of various etiologies, with scleral contact lenses. Three patients (five eyes) with ptosis resulting from levator dehiscence due to long-term rigid gas permeable contact lens wear for keratoconus, phthisis bulbi, and myopathy due to Kearns-Sayre syndrome were identified during a 2-year period. They were fitted with scleral contact lenses in order to provide cosmesis by lifting the upper eyelid with the bulk of the lens, and simultaneously provide vision correction where applicable. The scleral contact lenses provided comfortable wear, significantly improved cosmesis as both palpebral aperture and marginal reflex distance were increased, and visual acuity was also subjectively and objectively improved. Two of the patients opted for the scleral contact lenses, whereas the parents of the third patient, a 10-year-old girl with Kearns-Sayre syndrome, chose to undergo ptosis surgery due to handling issues of the scleral contact lenses. Scleral contact lenses can be a useful addition to the treatment option for patients with complicated ptosis.

Gravitational lensing frequencies - Galaxy cross-sections and selection effects

NASA Technical Reports Server (NTRS)

Fukugita, Masataka; Turner, Edwin L.

1991-01-01

Four issues - (1) the best currently available data on the galaxy velocity-dispersion distribution, (2) the effects of finite core radii potential ellipticity on lensing cross sections, (3) the predicted distribution of lens image separations compared to observational angular resolutions, and (4) the preferential inclusion of lens systems in flux limited samples - are considered in order to facilitate more realistic predictions of multiple image galaxy-quasar lensing frequencies. It is found that (1) the SIS lensing parameter F equals 0.047 +/-0.019 with almost 90 percent contributed by E and S0 galaxies, (2) observed E and S0 core radii are remarkably small, yielding a factor of less than about 2 reduction in total lensing cross sections, (3) 50 percent of galaxy-quasar lenses have image separations greater than about 1.3 arcsec, and (4) amplification bias factors are large and must be carefully taken into account. It is concluded that flat universe models excessively dominated by the cosmological constant are not favored by the small observed galaxy-quasar lensing rate.

Two-Season Atacama Cosmology Telescope Polarimeter Lensing Power Spectrum

NASA Technical Reports Server (NTRS)

Shewin, Blake D.; van Engelen, Alexander; Sehgal, Neelima; Madhavacheril, Mathew; Addison, Graeme E.; Aiola, Simone; Allison, Rupert; Battaglia, Nicholas; Becker, Daniel T.; Beall, James A.;

Tonopen XL assessment of intraocular pressure through silicone hydrogel contact lenses.

PubMed

Schornack, Muriel; Rice, Melissa; Hodge, David

2012-09-01

To assess the accuracy of Tonopen XL measurement of intraocular pressure (IOP) through low-power (-0.25 to -3.00) and high power (-3.25 to -6.00) silicone hydrogel lenses of 3 different materials (galyfilcon A, senofilcon A, and lotrafilcon B). Seventy-eight patients were recruited for participation in this study. All were habitual wearers of silicone hydrogel contact lenses, and none had been diagnosed with glaucoma, ocular hypertension, or anterior surface disease. IOP was measured with and without lenses in place in the right eye only. Patients were randomized to initial measurement either with or without the lens in place. A single examiner collected all data. No statistically significant differences were noted between IOP measured without lenses and IOP measured through low-power lotrafilcon B lenses or high-power or low-power galyfilcon A and senofilcon A lenses. However, we did find a statistically significant difference between IOP measured without lenses and IOP measured through high-power lotrafilcon B lenses. In general, Tonopen XL measurement of IOP through silicone hydrogel lenses may be sufficiently accurate for clinical purposes. However, Tonopen XL may overestimate IOP if performed through a silicone hydrogel lens of relatively high modulus.

Contact Lenses for Color Blindness.

PubMed

Badawy, Abdel-Rahman; Hassan, Muhammad Umair; Elsherif, Mohamed; Ahmed, Zubair; Yetisen, Ali K; Butt, Haider

2018-06-01

Color vision deficiency (color blindness) is an inherited genetic ocular disorder. While no cure for this disorder currently exists, several methods can be used to increase the color perception of those affected. One such method is the use of color filtering glasses which are based on Bragg filters. While these glasses are effective, they are high cost, bulky, and incompatible with other vision correction eyeglasses. In this work, a rhodamine derivative is incorporated in commercial contact lenses to filter out the specific wavelength bands (≈545-575 nm) to correct color vision blindness. The biocompatibility assessment of the dyed contact lenses in human corneal fibroblasts and human corneal epithelial cells shows no toxicity and cell viability remains at 99% after 72 h. This study demonstrates the potential of the dyed contact lenses in wavelength filtering and color vision deficiency management. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Corneal erosions, bacterial contamination of contact lenses, and microbial keratitis.

PubMed

Willcox, Mark D P; Naduvilath, Thomas J; Vaddavalli, Pravin K; Holden, Brien A; Ozkan, Jerome; Zhu, Hua

2010-11-01

To estimate the rate of corneal erosion coupled with gram-negative bacterial contamination of contact lenses and compare this with the rate of microbial keratitis (MK) with contact lenses. The rate of corneal erosion and contact lens contamination by gram-negative bacteria were calculated from several prospective trials. These rates were used to calculate the theoretical rate of corneal erosion happening at the same time as wearing a contact lens contaminated with gram-negative bacteria. This theoretical rate was then compared with the rates of MK reported in various epidemiological and clinical trials. Corneal erosions were more frequent during extended wear (0.6-2.6% of visits) compared with daily wear (0.01-0.05% of visits). No corneal erosions were observed for lenses worn on a daily disposable basis. Contamination rates for lenses worn on a daily disposable basis were the lowest (2.4%), whereas they were the highest for low Dk lenses worn on an extended wear basis (7.1%). The estimated rate of corneal erosions occurring at the same time as wearing lenses contaminated with gram-negative bacteria was the lowest during daily wear of low Dk lenses (1.56/10,000 [95% CI: 0.23-10.57]) and the highest during extended wear of high Dk lenses (38.55/10,000 [95% CI: 24.77-60.04]). These rates were similar in magnitude to the rates reported for MK of different hydrogel lenses worn on differing wear schedules. The coincidence of corneal erosions during lens wear with gram-negative bacterial contamination of lenses may account for the relative incidence of MK during lens wear with different lens materials and modes of use.

Broad-search algorithms for finding triple-and quadruple-satellite-aided captures at Jupiter from 2020 to 2080

NASA Astrophysics Data System (ADS)

Lynam, Alfred E.

2015-04-01

Multiple-satellite-aided capture is a -efficient technique for capturing a spacecraft into orbit at Jupiter. However, finding the times when the Galilean moons of Jupiter align such that three or four of them can be encountered in a single pass is difficult using standard astrodynamics algorithms such as Lambert's problem. In this paper, we present simple but powerful techniques that simplify the dynamics and geometry of the Galilean satellites so that many of these triple- and quadruple-satellite-aided capture sequences can be found quickly over an extended 60-year time period from 2020 to 2080. The techniques find many low-fidelity trajectories that could be used as initial guesses for future high-fidelity optimization. Results indicate the existence of approximately 3,100 unique triple-satellite-aided capture trajectories and 6 unique quadruple-satellite-aided capture trajectories during the 60-year time period. The entire search takes less than one minute of computational time.

Periodic self-lensing from accreting massive black hole binaries

NASA Astrophysics Data System (ADS)

D'Orazio, Daniel J.; Di Stefano, Rosanne

2018-03-01

Nearly 150 massive black hole binary (MBHB) candidates at sub-pc orbital separations have been reported in recent literature. Nevertheless, the definitive detection of even a single such object remains elusive. If at least one of the black holes is accreting, the light emitted from its accretion disc will be lensed by the other black hole for binary orbital inclinations near to the line of sight. This binary self-lensing could provide a unique signature of compact MBHB systems. We show that, for MBHBs with masses in the range 106-1010 M⊙ and with orbital periods less than ˜10 yr, strong lensing events should occur in one to 10s of per cent of MBHB systems that are monitored for an entire orbit. Lensing events will last from days for the less massive, shorter period MBHBs to a year for the most massive ˜10 year orbital period MBHBs. At small inclinations of the binary orbit to the line of sight, lensing must occur and will be accompanied by periodicity due to the relativistic Doppler boost. Flares at the same phase as the otherwise average flux of the Doppler modulation would be a smoking gun signature of self-lensing and can be used to constrain binary parameters. For MBHBs with separation ≳100 Schwarzschild radii, we show that finite-sized source effects could serve as a probe of MBH accretion disc structure. Finally, we stress that our lensing probability estimate implies that ˜10 of the known MBHB candidates identified through quasar periodicity should exhibit strong lensing flares.

The Master Lens Database and The Orphan Lenses Project

NASA Astrophysics Data System (ADS)

Moustakas, Leonidas

2012-10-01

Strong gravitational lenses are uniquely suited for the study of dark matter structure and substructure within massive halos of many scales, act as gravitational telescopes for distant faint objects, and can give powerful and competitive cosmological constraints. While hundreds of strong lenses are known to date, spanning five orders of magnitude in mass scale, thousands will be identified this decade. To fully exploit the power of these objects presently, and in the near future, we are creating the Master Lens Database. This is a clearinghouse of all known strong lens systems, with a sophisticated and modern database of uniformly measured and derived observational and lens-model derived quantities, using archival Hubble data across several instruments. This Database enables new science that can be done with a comprehensive sample of strong lenses. The operational goal of this proposal is to develop the process and the code to semi-automatically stage Hubble data of each system, create appropriate masks of the lensing objects and lensing features, and derive gravitational lens models, to provide a uniform and fairly comprehensive information set that is ingested into the Database. The scientific goal for this team is to use the properties of the ensemble of lenses to make a new study of the internal structure of lensing galaxies, and to identify new objects that show evidence of strong substructure lensing, for follow-up study. All data, scripts, masks, model setup files, and derived parameters, will be public, and free. The Database will be accessible online and through a sophisticated smartphone application, which will also be free.

An assessment of the measurement of the Lense Thirring effect in the Earth gravity field, in reply to: “On the measurement of the Lense Thirring effect using the nodes of the LAGEOS satellites, in reply to “On the reliability of the so far performed tests for measuring the Lense Thirring effect with the LAGEOS satellites” by L. Iorio,” by I. Ciufolini and E. Pavlis

NASA Astrophysics Data System (ADS)

Iorio, L.

2007-03-01

In this paper we reply to recent claims by Ciufolini and Pavlis about certain aspects of the measurement of the general relativistic Lense-Thirring effect in the gravitational field of the Earth. (I) The proposal by such authors of using the existing satellites endowed with some active mechanism of compensation of the non-gravitational perturbations as an alternative strategy to improve the currently ongoing Lense-Thirring tests is unfeasible because of the impact of the uncancelled even zonal harmonics of the geopotential and of some time-dependent tidal perturbations. (II) It is shown that their criticisms about the possibility of using the existing altimeter Jason-1 and laser-ranged Ajisai satellites are groundless. (III) Ciufolini and Pavlis also claimed that we would have explicitly proposed to use the mean anomaly of the LAGEOS satellites in order to improve the accuracy of the Lense-Thirring tests. We prove that it is false. In regard to the mean anomaly of the LAGEOS satellites, Ciufolini himself did use such an orbital element in some previously published tests. About the latest test performed with the LAGEOS satellites, (IV) we discuss the cross-coupling between the inclination errors and the first even zonal harmonic as another possible source of systematic error affecting it with an additional 9% bias. (V) Finally, we stress the weak points of the claims about the origin of the two-nodes LAGEOS-LAGEOS II combination used in that test.

Tear exchange and contact lenses: A review

PubMed Central

Muntz, Alex; Subbaraman, Lakshman N.; Sorbara, Luigina; Jones, Lyndon

2015-01-01

Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. PMID:25575892

Impact of Relational Coordination on Nurse Job Satisfaction, Work Engagement and Burnout: Achieving the Quadruple Aim.

PubMed

Havens, Donna Sullivan; Gittell, Jody Hoffer; Vasey, Joseph

2018-03-01

To explore how relational coordination, known to enhance quality and efficiency outcomes for patients and hospitals, impacts direct care nurse outcomes such as burnout, work engagement, and job satisfaction, addressing the "Quadruple Aim," to improve the experience of providing care. Hospitals are complex organizations in which multiple providers work interdependently, under conditions of uncertainty and time constraints, to deliver safe quality care despite differences in specialization, training, and status. Relational coordination-communicating and relating for the purpose of task integration-is known to improve quality, safety, and efficiency under these conditions, but less is known about its impact on the well-being of direct care providers themselves. Surveys measuring relational coordination among nurses and other types of providers as well as job-related outcomes in 5 acute care community hospitals were completed by direct care RNs. Relational coordination was significantly related to increased job satisfaction, increased work engagement, and reduced burnout. Relational coordination contributes to the well-being of direct care nurses, addressing the Quadruple Aim by improving the experience of providing care.

Chromatic confocal microscope using hybrid aspheric diffractive lenses

NASA Astrophysics Data System (ADS)

Rayer, Mathieu; Mansfield, Daniel

2014-05-01

A chromatic confocal microscope is a single point non-contact distance measurement sensor. For three decades the vast majority of the chromatic confocal microscope use refractive-based lenses to code the measurement axis chromatically. However, such an approach is limiting the range of applications. In this paper the performance of refractive, diffractive and Hybrid aspheric diffractive are compared. Hybrid aspheric diffractive lenses combine the low geometric aberration of a diffractive lens with the high optical power of an aspheric lens. Hybrid aspheric diffractive lenses can reduce the number of elements in an imaging system significantly or create large hyper- chromatic lenses for sensing applications. In addition, diffractive lenses can improve the resolution and the dynamic range of a chromatic confocal microscope. However, to be suitable for commercial applications, the diffractive optical power must be significant. Therefore, manufacturing such lenses is a challenge. We show in this paper how a theoretical manufacturing model can demonstrate that the hybrid aspheric diffractive configuration with the best performances is achieved by step diffractive surface. The high optical quality of step diffractive surface is then demonstrated experimentally. Publisher's Note: This paper, originally published on 5/10/14, was replaced with a corrected/revised version on 5/19/14. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance.

Augmented Quadruple-Phase Contrast Media Administration and Triphasic Scan Protocol Increases Image Quality at Reduced Radiation Dose During Computed Tomography Urography.

PubMed

Saade, Charbel; Mohamad, May; Kerek, Racha; Hamieh, Nadine; Alsheikh Deeb, Ibrahim; El-Achkar, Bassam; Tamim, Hani; Abdul Razzak, Farah; Haddad, Maurice; Abi-Ghanem, Alain S; El-Merhi, Fadi

The aim of this article was to investigate the opacification of the renal vasculature and the urogenital system during computed tomography urography by using a quadruple-phase contrast media in a triphasic scan protocol. A total of 200 patients with possible urinary tract abnormalities were equally divided between 2 protocols. Protocol A used the conventional single bolus and quadruple-phase scan protocol (pre, arterial, venous, and delayed), retrospectively. Protocol B included a quadruple-phase contrast media injection with a triphasic scan protocol (pre, arterial and combined venous, and delayed), prospectively. Each protocol used 100 mL contrast and saline at a flow rate of 4.5 mL. Attenuation profiles and contrast-to-noise ratio of the renal arteries, veins, and urogenital tract were measured. Effective radiation dose calculation, data analysis by independent sample t test, receiver operating characteristic, and visual grading characteristic analyses were performed. In arterial circulation, only the inferior interlobular arteries in both protocols showed a statistical significance (P < 0.05). Venously, the inferior vena cava, proximal and distal renal veins demonstrated a significant opacification reduction in protocol B than in protocol A (P < 0.001). Protocol B showed a significantly higher mean contrast-to-noise ratio than protocol A (protocol B: 22.68 ± 13.72; protocol A: 14.75 ± 5.76; P < 0.001). Radiation dose was significantly reduced in protocol B (7.38 ± 2.22 mSv) than in protocol A (12.28 ± 2.72 mSv) (P < 0.001). Visual grading characteristic (P < 0.027) and receiver operating characteristic (P < 0.0001) analyses demonstrated a significant preference for protocol B. In computed tomography urography, augmented quadruple-phase contrast media and triphasic scan protocol usage increases the image quality at a reduced radiation dose.

Stationary nonimaging lenses for solar concentration.

PubMed

Kotsidas, Panagiotis; Chatzi, Eleni; Modi, Vijay

2010-09-20

A novel approach for the design of refractive lenses is presented, where the lens is mounted on a stationary aperture and the Sun is tracked by a moving solar cell. The purpose of this work is to design a quasi-stationary concentrator by replacing the two-axis tracking of the Sun with internal motion of the miniaturized solar cell inside the module. Families of lenses are designed with a variation of the simultaneous multiple surface technique in which the sawtooth genetic algorithm is implemented to optimize the geometric variables of the optic in order to produce high fluxes for a range of incidence angles. Finally, we show examples of the technique for lenses with 60° and 30° acceptance half-angles, with low to medium attainable concentrations.

CMB ISW-lensing bispectrum from cosmic strings

NASA Astrophysics Data System (ADS)

Yamauchi, Daisuke; Sendouda, Yuuiti; Takahashi, Keitaro

2014-02-01

We study the effect of weak lensing by cosmic (super-)strings on the higher-order statistics of the cosmic microwave background (CMB). A cosmic string segment is expected to cause weak lensing as well as an integrated Sachs-Wolfe (ISW) effect, the so-called Gott-Kaiser-Stebbins (GKS) effect, to the CMB temperature fluctuation, which are thus naturally cross-correlated. We point out that, in the presence of such a correlation, yet another kind of the post-recombination CMB temperature bispectra, the ISW-lensing bispectra, will arise in the form of products of the auto- and cross-power spectra. We first present an analytic method to calculate the autocorrelation of the temperature fluctuations induced by the strings, and the cross-correlation between the temperature fluctuation and the lensing potential both due to the string network. In our formulation, the evolution of the string network is assumed to be characterized by the simple analytic model, the velocity-dependent one scale model, and the intercommutation probability is properly incorporated in order to characterize the possible superstringy nature. Furthermore, the obtained power spectra are dominated by the Poisson-distributed string segments, whose correlations are assumed to satisfy the simple relations. We then estimate the signal-to-noise ratios of the string-induced ISW-lensing bispectra and discuss the detectability of such CMB signals from the cosmic string network. It is found that in the case of the smaller string tension, Gμ << 10-7, the ISW-lensing bispectrum induced by a cosmic string network can constrain the string-model parameters even more tightly than the purely GKS-induced bispectrum in the ongoing and future CMB observations on small scales.

Non-Gaussian information from weak lensing data via deep learning

NASA Astrophysics Data System (ADS)

Gupta, Arushi; Matilla, José Manuel Zorrilla; Hsu, Daniel; Haiman, Zoltán

2018-05-01

Weak lensing maps contain information beyond two-point statistics on small scales. Much recent work has tried to extract this information through a range of different observables or via nonlinear transformations of the lensing field. Here we train and apply a two-dimensional convolutional neural network to simulated noiseless lensing maps covering 96 different cosmological models over a range of {Ωm,σ8} . Using the area of the confidence contour in the {Ωm,σ8} plane as a figure of merit, derived from simulated convergence maps smoothed on a scale of 1.0 arcmin, we show that the neural network yields ≈5 × tighter constraints than the power spectrum, and ≈4 × tighter than the lensing peaks. Such gains illustrate the extent to which weak lensing data encode cosmological information not accessible to the power spectrum or even other, non-Gaussian statistics such as lensing peaks.

Absorbance and light scattering of lenses organ cultured with glucose.

PubMed

Alghamdi, Ali Hendi Sahmi; Mohamed, Hasabelrasoul; Sledge, Samiyyah M; Borchman, Douglas

2018-06-06

Purpose/Aim: Diabetes is one of the major factors related to cataract. Our aim was to determine if the attenuation of light through glucose treated lenses was due to light scattering from structural changes or absorbance from metabolic changes. Human and rat lenses were cultured in a medium with and without 55 mM glucose for a period of five days. Absorbance and light scattering were measured using a ultraviolet spectrometer. Aldose reductase and catalase activity, RAGE, and glutathione were measured using classical assays. Almost all of the glucose related attenuation of light through the human lens was due to light scattering from structural changes. Glucose treatment caused three absorbance band to appear at 484, 540 to 644 and 657 nm in both the rat and human lens. The optimum time point for equilibration of human lenses was found to be between 2 and 3 days in organ culture. Glucose caused a more significant effect on the opacity of human lenses compared with rat lenses. Since the levels of glutathione, catalase and aldose reductase were reduced in glucose treated rat lenses compared with untreated lenses, glucose may have caused oxidative stress on the rat lens. The absorbance and light scattering of glucose treated lenses in organ culture were quantitated for the first time which could be important for future studies designed to test the efficacy of agents to ameliorate the opacity. Almost all of the glucose related attenuation of light through the human lens was due to light scattering from structural changes and not absorbance from metabolic changes. Glucose caused a more significant effect on the opacity of human lenses compared with rat lenses. The lens model employed could be used to study the efficacy of agents that potentially ameliorate lens opacity.

Cosmology with Strong-lensing Systems

NASA Astrophysics Data System (ADS)

Cao, Shuo; Biesiada, Marek; Gavazzi, Raphaël; Piórkowska, Aleksandra; Zhu, Zong-Hong

2015-06-01

In this paper, we assemble a catalog of 118 strong gravitational lensing systems from the Sloan Lens ACS Survey, BOSS emission-line lens survey, Lens Structure and Dynamics, and Strong Lensing Legacy Survey and use them to constrain the cosmic equation of state. In particular, we consider two cases of dark energy phenomenology: the XCDM model, where dark energy is modeled by a fluid with constant w equation-of-state parameter, and in the Chevalier-Polarski-Linder (CPL) parameterization, where w is allowed to evolve with redshift, w(z)={{w}0}+{{w}1}\\frac{z}{1 + z} . We assume spherically symmetric mass distribution in lensing galaxies, but we relax the rigid assumption of the SIS model in favor of a more general power-law index γ, also allowing it to evolve with redshifts γ (z). Our results for the XCDM cosmology show agreement with values (concerning both w and γ parameters) obtained by other authors. We go further and constrain the CPL parameters jointly with γ (z). The resulting confidence regions for the parameters are much better than those obtained with a similar method in the past. They are also showing a trend of being complementary to the Type Ia supernova data. Our analysis demonstrates that strong gravitational lensing systems can be used to probe cosmological parameters like the cosmic equation of state for dark energy. Moreover, they have a potential to judge whether the cosmic equation of state evolved with time or not.

Halloween Safety: Costumes, Candy, and Colored Contact Lenses

MedlinePlus

... Consumer Updates Halloween Safety: Costumes, Candy, and Colored Contact Lenses Share Tweet Linkedin Pin it More sharing ... or witch, poor costume choices—including decorative (colored) contact lenses and flammable costumes—and face paint allergies ...

Reconfigurable and responsive droplet-based compound micro-lenses

PubMed Central

Nagelberg, Sara; Zarzar, Lauren D.; Nicolas, Natalie; Subramanian, Kaushikaram; Kalow, Julia A.; Sresht, Vishnu; Blankschtein, Daniel; Barbastathis, George; Kreysing, Moritz; Swager, Timothy M.; Kolle, Mathias

2017-01-01

Micro-scale optical components play a crucial role in imaging and display technology, biosensing, beam shaping, optical switching, wavefront-analysis, and device miniaturization. Herein, we demonstrate liquid compound micro-lenses with dynamically tunable focal lengths. We employ bi-phase emulsion droplets fabricated from immiscible hydrocarbon and fluorocarbon liquids to form responsive micro-lenses that can be reconfigured to focus or scatter light, form real or virtual images, and display variable focal lengths. Experimental demonstrations of dynamic refractive control are complemented by theoretical analysis and wave-optical modelling. Additionally, we provide evidence of the micro-lenses' functionality for two potential applications—integral micro-scale imaging devices and light field display technology—thereby demonstrating both the fundamental characteristics and the promising opportunities for fluid-based dynamic refractive micro-scale compound lenses. PMID:28266505

Mathematics of gravitational lensing: multiple imaging and magnification

NASA Astrophysics Data System (ADS)

Petters, A. O.; Werner, M. C.

2010-09-01

The mathematical theory of gravitational lensing has revealed many generic and global properties. Beginning with multiple imaging, we review Morse-theoretic image counting formulas and lower bound results, and complex-algebraic upper bounds in the case of single and multiple lens planes. We discuss recent advances in the mathematics of stochastic lensing, discussing a general formula for the global expected number of minimum lensed images as well as asymptotic formulas for the probability densities of the microlensing random time delay functions, random lensing maps, and random shear, and an asymptotic expression for the global expected number of micro-minima. Multiple imaging in optical geometry and a spacetime setting are treated. We review global magnification relation results for model-dependent scenarios and cover recent developments on universal local magnification relations for higher order caustics.

Reconfigurable and responsive droplet-based compound micro-lenses.

PubMed

Nagelberg, Sara; Zarzar, Lauren D; Nicolas, Natalie; Subramanian, Kaushikaram; Kalow, Julia A; Sresht, Vishnu; Blankschtein, Daniel; Barbastathis, George; Kreysing, Moritz; Swager, Timothy M; Kolle, Mathias

2017-03-07

Micro-scale optical components play a crucial role in imaging and display technology, biosensing, beam shaping, optical switching, wavefront-analysis, and device miniaturization. Herein, we demonstrate liquid compound micro-lenses with dynamically tunable focal lengths. We employ bi-phase emulsion droplets fabricated from immiscible hydrocarbon and fluorocarbon liquids to form responsive micro-lenses that can be reconfigured to focus or scatter light, form real or virtual images, and display variable focal lengths. Experimental demonstrations of dynamic refractive control are complemented by theoretical analysis and wave-optical modelling. Additionally, we provide evidence of the micro-lenses' functionality for two potential applications-integral micro-scale imaging devices and light field display technology-thereby demonstrating both the fundamental characteristics and the promising opportunities for fluid-based dynamic refractive micro-scale compound lenses.

Occlusion properties of prosthetic contact lenses for the treatment of amblyopia.

PubMed

Collins, Randall S; McChesney, Megan E; McCluer, Craig A; Schatz, Martha P

2008-12-01

The efficacy of opaque contact lenses as occlusion therapy for amblyopia has been established in the literature. Prosthetic contact lenses use similar tints to improve cosmesis in scarred or deformed eyes and may be an alternative in occlusion therapy. To test this idea, we determined the degree of vision penalization elicited by prosthetic contact lenses and their effect on peripheral fusion. We tested 19 CIBA Vision DuraSoft 3 Prosthetic soft contact lenses with varying iris prints, underprints, and opaque pupil sizes in 10 volunteers with best-corrected Snellen distance visual acuity of 20/20 or better in each eye. Snellen visual acuity and peripheral fusion using the Worth 4-Dot test at near were measured on each subject wearing each of the 19 lenses. Results were analyzed with 3-factor analysis of variance. Mean visual acuity through the various lenses ranged from 20/79 to 20/620. Eight lenses allowed preservation of peripheral fusion in 50% or more of the subjects tested. Iris print pattern and opaque pupil size were significant factors in determining visual acuity (p < 0.05). Sufficient vision penalization can be achieved to make occlusion with prosthetic contact lenses a viable therapy for amblyopia. The degree of penalization can be varied and different iris print patterns and pupil sizes, using peripheral fusion, can be preserved with some lenses. Prosthetic contact lenses can be more cosmetically appealing and more tolerable than other amblyopia treatment modalities. These factors may improve compliance in occlusion therapy.

Direct probe of dark energy through gravitational lensing effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Hong-Jian; Zhang, Zhen, E-mail: hjhe@tsinghua.edu.cn, E-mail: zh.zhang@pku.edu.cn

We show that gravitational lensing can provide a direct method to probe the nature of dark energy at astrophysical scales. For lensing system as an isolated astrophysical object, we derive the dark energy contribution to gravitational potential as a repulsive power-law term, containing a generic equation of state parameter w . We find that it generates w -dependent and position-dependent modification to the conventional light orbital equation of w =−1. With post-Newtonian approximation, we compute its direct effect for an isolated lensing system at astrophysical scales and find that the dark energy force can deflect the path of incident lightmore » rays. We demonstrate that the dark-energy-induced deflection angle Δα{sub DE}∝ M {sup (1+1/3} {sup w} {sup )} (with 1+1/3 w > 0), which increases with the lensing mass M and consistently approaches zero in the limit M → 0. This effect is distinctive because dark energy tends to diffuse the rays and generates concave lensing effect . This is in contrast to the conventional convex lensing effect caused by both visible and dark matter. Measuring such concave lensing effect can directly probe the existence and nature of dark energy. We estimate this effect and show that the current gravitational lensing experiments are sensitive to the direct probe of dark energy at astrophysical scales. For the special case w =−1, our independent study favors the previous works that the cosmological constant can affect light bending, but our prediction qualitatively and quantitatively differ from the literature, including our consistent realization of Δα{sub DE} → 0 (under 0 M → ) at the leading order.« less

Oxygen permeability of hydrogel contact lenses with organosilicon moieties.

PubMed

Compañ, V; Andrio, A; López-Alemany, A; Riande, E; Refojo, M F

2002-07-01

Oxygen transport through two extended wear (day and night) hydrogel contact lenses that contain organosilicon moieties (balafilcon A and lotrafilcon A) was studied in the hydrate (hydrogel) and dry (xerogel) states. The water uptake increased the oxygen permeability [(Dk)app] and transmissibility [Dk/L(av)] coefficients of the dry materials by about 70%. The (Dk)app for the hydrated lenses was determined following the so-called stack procedure. The values obtained were 107 +/- 4 barrer for balafilcon A and 141 +/- 5 barrer for lotrafilcon A, about 5-10 times larger than those previously reported for conventional (without organosilicon moieties) extended wear hydrogels contact lenses. The Dk/L(av) for -3.00 diopter lenses (harmonic average thickness, L(av) = 75 +/- 2 microm for lotrafilcon, and 85 +/- 2 microm for balafilcon) was 123 +/- 6 barrer/cm for balafilcon A and 183 +/- 8 barrer/cm for lotralicon A. The minimum oxygen transmissibility 87 barrer/cm stipulated by Holden and Mertz to avoid corneal edema with extended wear contact can be easily achieved with lotrafilcon and balafilcon lenses of diverse dioptric powers if the central and peripheral thickness of the lenses are kept below the critical level of oxygen transmissibility.

Two-season Atacama Cosmology Telescope polarimeter lensing power spectrum

NASA Astrophysics Data System (ADS)

Sherwin, Blake D.; van Engelen, Alexander; Sehgal, Neelima; Madhavacheril, Mathew; Addison, Graeme E.; Aiola, Simone; Allison, Rupert; Battaglia, Nicholas; Becker, Daniel T.; Beall, James A.; Bond, J. Richard; Calabrese, Erminia; Datta, Rahul; Devlin, Mark J.; Dünner, Rolando; Dunkley, Joanna; Fox, Anna E.; Gallardo, Patricio; Halpern, Mark; Hasselfield, Matthew; Henderson, Shawn; Hill, J. Colin; Hilton, Gene C.; Hubmayr, Johannes; Hughes, John P.; Hincks, Adam D.; Hlozek, Renée; Huffenberger, Kevin M.; Koopman, Brian; Kosowsky, Arthur; Louis, Thibaut; Maurin, Loïc; McMahon, Jeff; Moodley, Kavilan; Naess, Sigurd; Nati, Federico; Newburgh, Laura; Niemack, Michael D.; Page, Lyman A.; Sievers, Jonathan; Spergel, David N.; Staggs, Suzanne T.; Thornton, Robert J.; Van Lanen, Jeff; Vavagiakis, Eve; Wollack, Edward J.

2017-06-01

We report a measurement of the power spectrum of cosmic microwave background (CMB) lensing from two seasons of Atacama Cosmology Telescope polarimeter (ACTPol) CMB data. The CMB lensing power spectrum is extracted from both temperature and polarization data using quadratic estimators. We obtain results that are consistent with the expectation from the best-fit Planck Λ CDM model over a range of multipoles L =80 - 2100 , with an amplitude of lensing Alens=1.06 ±0.15 (stat )±0.06 (sys ) relative to Planck. Our measurement of the CMB lensing power spectrum gives σ8Ωm0.25=0.643 ±0.054 ; including baryon acoustic oscillation scale data, we constrain the amplitude of density fluctuations to be σ8=0.831 ±0.053 . We also update constraints on the neutrino mass sum. We verify our lensing measurement with a number of null tests and systematic checks, finding no evidence of significant systematic errors. This measurement relies on a small fraction of the ACTPol data already taken; more precise lensing results can therefore be expected from the full ACTPol data set.

Gravitational Lenses and the Structure and Evolution of Galaxies

NASA Technical Reports Server (NTRS)

Oliversen, Ronald J. (Technical Monitor); Kochanek, Christopher

2004-01-01

During the first year of the project we completed five papers, each of which represents a new direction in the theory and interpretation of gravitational lenses. In the first paper, The Importance of Einstein Rings, we developed the first theory for the formation and structure of the Einstein rings formed by lensing extended sources like the host galaxies of quasar and radio sources. In the second paper, Cusped Mass Models Of Gravitational Lenses, we introduced a new class of lens models. In the third paper, Global Probes of the Impact of Baryons on Dark Matter Halos, we made the first globally consistent models for the separation distribution of gravitational lenses including both galaxy and cluster lenses. The last two papers explore the properties of two lenses in detail. During the second year we have focused more closely on the relationship of baryons and dark matter. In the third year we have been further examining the relationship between baryons and dark matter. In the present year we extended our statistical analysis of lens mass distributions using a self-similar model for the halo mass distribution as compared to the luminous galaxy.

Lensing of 21-cm fluctuations by primordial gravitational waves.

PubMed

Book, Laura; Kamionkowski, Marc; Schmidt, Fabian

2012-05-25

Weak-gravitational-lensing distortions to the intensity pattern of 21-cm radiation from the dark ages can be decomposed geometrically into curl and curl-free components. Lensing by primordial gravitational waves induces a curl component, while the contribution from lensing by density fluctuations is strongly suppressed. Angular fluctuations in the 21-cm background extend to very small angular scales, and measurements at different frequencies probe different shells in redshift space. There is thus a huge trove of information with which to reconstruct the curl component of the lensing field, allowing tensor-to-scalar ratios conceivably as small as r~10(-9)-far smaller than those currently accessible-to be probed.

Management of complications associated with lathe-cut soft contact lenses.

PubMed

Freeman, M I

1979-06-01

At the present time, nine lathe-cut lenses are FDA approved and commercially available in the United States. Complications of lathe-cut soft contact lenses cover a wide spectrum of problems. Five significant complications of lathe-cut lenses and their prevention and therapeutic management are discussed.

Stellar Populations of Highly Magnified Lensed Galaxies: Young Starbursts at Z approximately 2

NASA Technical Reports Server (NTRS)

Wuyts, Eva; Rigby, Jane R.; Gladders, Michael D.; Gilbank, David G.; Sharon, Keren; Gralla, Megan B.; Bayliss, Matthew B.

2012-01-01

We present a comprehensive analysis of the rest-frame UV to near-IR spectral energy distributions (SEDs) and rest-frame optical spectra of four of the brightest gravitationally lensed galaxies in the literature: RCSGA 032727-132609 at z = 1.70, MS1512-cB58 at z = 2.73, SGAS J152745.1+065219 at z = 2.76, and SGAS J122651.3+215220 at z = 2.92. This includes new Spitzer imaging for RCSGA0327 as well as new spectra, near-IR imaging and Spitzer imaging for SGAS1527 and SGAS1226. Lensing magnifications of 3-4 mag allow a detailed study of the stellar populations and physical conditions. We compare star formation rates (SFRs) as measured from the SED fit, the Ha and [O II] ?3727 emission lines, and the UV+IR bolometric luminosity where 24 micron photometry is available. The SFR estimate from the SED fit is consistently higher than the other indicators, which suggests that the Calzetti dust extinction law used in the SED fitting is too flat for young star-forming galaxies at z 2. Our analysis finds similar stellar population parameters for all four lensed galaxies: stellar masses (3-7) ? 10(exp 9)Solar M young ages approx 100 Myr, little dust content E(B - V) = 0.10-0.25, and SFRs around 20-100 solar M/ yr. Compared to typical values for the galaxy population at z approx. 2, this suggests we are looking at newly formed, starbursting systems that have only recently started the buildup of stellar mass. These results constitute the first detailed, uniform analysis of a sample of the growing number of strongly lensed galaxies known at z approx 2.

Testing the uniqueness of mass models using gravitational lensing

NASA Astrophysics Data System (ADS)

Walls, Levi; Williams, Liliya L. R.

2018-06-01

The positions of images produced by the gravitational lensing of background-sources provide insight to lens-galaxy mass distributions. Simple elliptical mass density profiles do not agree well with observations of the population of known quads. It has been shown that the most promising way to reconcile this discrepancy is via perturbations away from purely elliptical mass profiles by assuming two super-imposed, somewhat misaligned mass distributions: one is dark matter (DM), the other is a stellar distribution. In this work, we investigate if mass modelling of individual lenses can reveal if the lenses have this type of complex structure, or simpler elliptical structure. In other words, we test mass model uniqueness, or how well an extended source lensed by a non-trivial mass distribution can be modeled by a simple elliptical mass profile. We used the publicly-available lensing software, Lensmodel, to generate and numerically model gravitational lenses and “observed” image positions. We then compared “observed” and modeled image positions via root mean square (RMS) of their difference. We report that, in most cases, the RMS is ≤0.05‧‧ when averaged over an extended source. Thus, we show it is possible to fit a smooth mass model to a system that contains a stellar-component with varying levels of misalignment with a DM-component, and hence mass modelling cannot differentiate between simple elliptical versus more complex lenses.

RCSLenS: The Red Cluster Sequence Lensing Survey

NASA Astrophysics Data System (ADS)

Hildebrandt, H.; Choi, A.; Heymans, C.; Blake, C.; Erben, T.; Miller, L.; Nakajima, R.; van Waerbeke, L.; Viola, M.; Buddendiek, A.; Harnois-Déraps, J.; Hojjati, A.; Joachimi, B.; Joudaki, S.; Kitching, T. D.; Wolf, C.; Gwyn, S.; Johnson, N.; Kuijken, K.; Sheikhbahaee, Z.; Tudorica, A.; Yee, H. K. C.

2016-11-01

We present the Red Cluster Sequence Lensing Survey (RCSLenS), an application of the methods developed for the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS) to the ˜785 deg2, multi-band imaging data of the Red-sequence Cluster Survey 2. This project represents the largest public, sub-arcsecond seeing, multi-band survey to date that is suited for weak gravitational lensing measurements. With a careful assessment of systematic errors in shape measurements and photometric redshifts, we extend the use of this data set to allow cross-correlation analyses between weak lensing observables and other data sets. We describe the imaging data, the data reduction, masking, multi-colour photometry, photometric redshifts, shape measurements, tests for systematic errors, and a blinding scheme to allow for more objective measurements. In total, we analyse 761 pointings with r-band coverage, which constitutes our lensing sample. Residual large-scale B-mode systematics prevent the use of this shear catalogue for cosmic shear science. The effective number density of lensing sources over an unmasked area of 571.7 deg2 and down to a magnitude limit of r ˜ 24.5 is 8.1 galaxies per arcmin2 (weighted: 5.5 arcmin-2) distributed over 14 patches on the sky. Photometric redshifts based on four-band griz data are available for 513 pointings covering an unmasked area of 383.5 deg2. We present weak lensing mass reconstructions of some example clusters as well as the full survey representing the largest areas that have been mapped in this way. All our data products are publicly available through Canadian Astronomy Data Centre at http://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/en/community/rcslens/query.html in a format very similar to the CFHTLenS data release.

Statistical and systematic errors in the measurement of weak-lensing Minkowski functionals: Application to the Canada-France-Hawaii Lensing Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shirasaki, Masato; Yoshida, Naoki, E-mail: masato.shirasaki@utap.phys.s.u-tokyo.ac.jp

2014-05-01

The measurement of cosmic shear using weak gravitational lensing is a challenging task that involves a number of complicated procedures. We study in detail the systematic errors in the measurement of weak-lensing Minkowski Functionals (MFs). Specifically, we focus on systematics associated with galaxy shape measurements, photometric redshift errors, and shear calibration correction. We first generate mock weak-lensing catalogs that directly incorporate the actual observational characteristics of the Canada-France-Hawaii Lensing Survey (CFHTLenS). We then perform a Fisher analysis using the large set of mock catalogs for various cosmological models. We find that the statistical error associated with the observational effects degradesmore » the cosmological parameter constraints by a factor of a few. The Subaru Hyper Suprime-Cam (HSC) survey with a sky coverage of ∼1400 deg{sup 2} will constrain the dark energy equation of the state parameter with an error of Δw {sub 0} ∼ 0.25 by the lensing MFs alone, but biases induced by the systematics can be comparable to the 1σ error. We conclude that the lensing MFs are powerful statistics beyond the two-point statistics only if well-calibrated measurement of both the redshifts and the shapes of source galaxies is performed. Finally, we analyze the CFHTLenS data to explore the ability of the MFs to break degeneracies between a few cosmological parameters. Using a combined analysis of the MFs and the shear correlation function, we derive the matter density Ω{sub m0}=0.256±{sub 0.046}{sup 0.054}.« less

Impact of post-Born lensing on the CMB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pratten, Geraint; Lewis, Antony, E-mail: G.Pratten@Sussex.ac.uk, E-mail: antony@cosmologist.info

Lensing of the CMB is affected by post-Born lensing, producing corrections to the convergence power spectrum and introducing field rotation. We show numerically that the lensing convergence power spectrum is affected at the ∼< 0.2% level on accessible scales, and that this correction and the field rotation are negligible for observations with arcminute beam and noise levels ∼> 1 μK arcmin. The field rotation generates ∼ 2.5% of the total lensing B-mode polarization amplitude (0.2% in power on small scales), but has a blue spectrum on large scales, making it highly subdominant to the convergence B modes on scales wheremore » they are a source of confusion for the signal from primordial gravitational waves. Since the post-Born signal is non-linear, it also generates a bispectrum with the convergence. We show that the post-Born contributions to the bispectrum substantially change the shape predicted from large-scale structure non-linearities alone, and hence must be included to estimate the expected total signal and impact of bispectrum biases on CMB lensing reconstruction quadratic estimators and other observables. The field-rotation power spectrum only becomes potentially detectable for noise levels || 1 μK arcmin, but its bispectrum with the convergence may be observable at ∼ 3σ with Stage IV observations. Rotation-induced and convergence-induced B modes are slightly correlated by the bispectrum, and the bispectrum also produces additional contributions to the lensed BB power spectrum.« less

Fabrication of wedged multilayer Laue lenses

DOE PAGES

Prasciolu, M.; Leontowich, A. F. G.; Krzywinski, J.; ...

2015-01-01

We present a new method to fabricate wedged multilayer Laue lenses, in which the angle of diffracting layers smoothly varies in the lens to achieve optimum diffracting efficiency across the entire pupil of the lens. This was achieved by depositing a multilayer onto a flat substrate placed in the penumbra of a straight-edge mask. The distance between the mask and the substrate was calibrated and the multilayer Laue lens was cut in a position where the varying layer thickness and the varying layer tilt simultaneously satisfy the Fresnel zone plate condition and Bragg’s law for all layers in the stack.more » This method can be used to extend the achievable numerical aperture of multilayer Laue lenses to reach considerably smaller focal spot sizes than achievable with lenses composed of parallel layers.« less

Gravitational lensing, time delay, and gamma-ray bursts

NASA Technical Reports Server (NTRS)

Mao, Shude

1992-01-01

The probability distributions of time delay in gravitational lensing by point masses and isolated galaxies (modeled as singular isothermal spheres) are studied. For point lenses (all with the same mass) the probability distribution is broad, and with a peak at delta(t) of about 50 S; for singular isothermal spheres, the probability distribution is a rapidly decreasing function with increasing time delay, with a median delta(t) equals about 1/h month, and its behavior depends sensitively on the luminosity function of galaxies. The present simplified calculation is particularly relevant to the gamma-ray bursts if they are of cosmological origin. The frequency of 'recurrent' bursts due to gravitational lensing by galaxies is probably between 0.05 and 0.4 percent. Gravitational lensing can be used as a test of the cosmological origin of gamma-ray bursts.

CMB ISW-lensing bispectrum from cosmic strings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamauchi, Daisuke; Sendouda, Yuuiti; Takahashi, Keitaro, E-mail: yamauchi@resceu.s.u-tokyo.ac.jp, E-mail: sendouda@cc.hirosaki-u.ac.jp, E-mail: keitaro@sci.kumamoto-u.ac.jp

2014-02-01

We study the effect of weak lensing by cosmic (super-)strings on the higher-order statistics of the cosmic microwave background (CMB). A cosmic string segment is expected to cause weak lensing as well as an integrated Sachs-Wolfe (ISW) effect, the so-called Gott-Kaiser-Stebbins (GKS) effect, to the CMB temperature fluctuation, which are thus naturally cross-correlated. We point out that, in the presence of such a correlation, yet another kind of the post-recombination CMB temperature bispectra, the ISW-lensing bispectra, will arise in the form of products of the auto- and cross-power spectra. We first present an analytic method to calculate the autocorrelation ofmore » the temperature fluctuations induced by the strings, and the cross-correlation between the temperature fluctuation and the lensing potential both due to the string network. In our formulation, the evolution of the string network is assumed to be characterized by the simple analytic model, the velocity-dependent one scale model, and the intercommutation probability is properly incorporated in order to characterize the possible superstringy nature. Furthermore, the obtained power spectra are dominated by the Poisson-distributed string segments, whose correlations are assumed to satisfy the simple relations. We then estimate the signal-to-noise ratios of the string-induced ISW-lensing bispectra and discuss the detectability of such CMB signals from the cosmic string network. It is found that in the case of the smaller string tension, Gμ << 10{sup -7}, the ISW-lensing bispectrum induced by a cosmic string network can constrain the string-model parameters even more tightly than the purely GKS-induced bispectrum in the ongoing and future CMB observations on small scales.« less

Habitual wearers of colored lenses adapt more rapidly to the color changes the lenses produce.

PubMed

Engel, Stephen A; Wilkins, Arnold J; Mand, Shivraj; Helwig, Nathaniel E; Allen, Peter M

2016-08-01

The visual system continuously adapts to the environment, allowing it to perform optimally in a changing visual world. One large change occurs every time one takes off or puts on a pair of spectacles. It would be advantageous for the visual system to learn to adapt particularly rapidly to such large, commonly occurring events, but whether it can do so remains unknown. Here, we tested whether people who routinely wear spectacles with colored lenses increase how rapidly they adapt to the color shifts their lenses produce. Adaptation to a global color shift causes the appearance of a test color to change. We measured changes in the color that appeared "unique yellow", that is neither reddish nor greenish, as subjects donned and removed their spectacles. Nine habitual wearers and nine age-matched control subjects judged the color of a small monochromatic test light presented with a large, uniform, whitish surround every 5s. Red lenses shifted unique yellow to more reddish colors (longer wavelengths), and greenish lenses shifted it to more greenish colors (shorter wavelengths), consistent with adaptation "normalizing" the appearance of the world. In controls, the time course of this adaptation contained a large, rapid component and a smaller gradual one, in agreement with prior results. Critically, in habitual wearers the rapid component was significantly larger, and the gradual component significantly smaller than in controls. The total amount of adaptation was also larger in habitual wearers than in controls. These data suggest strongly that the visual system adapts with increasing rapidity and strength as environments are encountered repeatedly over time. An additional unexpected finding was that baseline unique yellow shifted in a direction opposite to that produced by the habitually worn lenses. Overall, our results represent one of the first formal reports that adjusting to putting on or taking off spectacles becomes easier over time, and may have important

Constraining f (R ) Gravity Theory Using Weak Lensing Peak Statistics from the Canada-France-Hawii-Telescope Lensing Survey

NASA Astrophysics Data System (ADS)

Liu, Xiangkun; Li, Baojiu; Zhao, Gong-Bo; Chiu, Mu-Chen; Fang, Wei; Pan, Chuzhong; Wang, Qiao; Du, Wei; Yuan, Shuo; Fu, Liping; Fan, Zuhui

2016-07-01

In this Letter, we report the observational constraints on the Hu-Sawicki f (R ) theory derived from weak lensing peak abundances, which are closely related to the mass function of massive halos. In comparison with studies using optical or x-ray clusters of galaxies, weak lensing peak analyses have the advantages of not relying on mass-baryonic observable calibrations. With observations from the Canada-France-Hawaii-Telescope Lensing Survey, our peak analyses give rise to a tight constraint on the model parameter |fR 0| for n =1 . The 95% C.L. is log10|fR 0|<-4.82 given WMAP9 priors on (Ωm , As ). With Planck15 priors, the corresponding result is log10|fR 0|<-5.16 .

Prescribing prophylactic antibiotics to users of therapeutic contact lenses.

PubMed

Colomé-Campos, J; Quevedo-Junyent, L; Godoy-Barreda, N; Martínez-Salcedo, I; Romero-Aroca, P

2013-03-01

To describe the benefits and optimum use of prophylactic antibiotics in users of therapeutic contact lenses (TCL). A microbiological study was carried out on samples from 33 patients who continuously wore TCL. The resistance to antibiotics of bacteria isolated in our health region was also reviewed. An assessment was also made on whether there were microorganisms of a higher pathogenic potential in TCL than conventional contact lenses, as reported in the literature. No bacteria were isolated from 17 (52%) of the 33 lenses studied. From the 16 (48%) remaining lenses, coagulase negative Staphylococci were isolated from 10 (62%), Propionibacterium acnes from 4 (25%), and Corynebacterium from 2 (13%). The high number of negative cultures and the presence of saprophytic bacteria indicate that prophylactic antibiotic treatment is not precise. The most frequent pathogenic bacteria found in contact lenses are strongly resistant to the current commercially available antibiotics. Copyright © 2012 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

Lensing bias to CMB measurements of compensated isocurvature perturbations

NASA Astrophysics Data System (ADS)

Heinrich, Chen He; Grin, Daniel; Hu, Wayne

2016-08-01

Compensated isocurvature perturbations (CIPs) are modes in which the baryon and dark matter density fluctuations cancel. They arise in the curvaton scenario as well as some models of baryogenesis. While they leave no observable effects on the cosmic microwave background (CMB) at linear order, they do spatially modulate two-point CMB statistics and can be reconstructed in a manner similar to gravitational lensing. Due to the similarity between the effects of CMB lensing and CIPs, lensing contributes nearly Gaussian random noise to the CIP estimator that approximately doubles the reconstruction noise power. Additionally, the cross correlation between lensing and the integrated Sachs-Wolfe effect generates a correlation between the CIP estimator and the temperature field even in the absence of a correlated CIP signal. For cosmic-variance limited temperature measurements out to multipoles l ≤2500 , subtracting a fixed lensing bias degrades the detection threshold for CIPs by a factor of 1.3, whether or not they are correlated with the adiabatic mode.

Effects of dental magnification lenses on indirect vision: a pilot study.

PubMed

Hoerler, Sarah B; Branson, Bonnie G; High, Anne M; Mitchell, Tanya Villalpando

2012-01-01

The purpose of this pilot study was to evaluate the effect of magnification lenses on the indirect vision skills of dental hygiene students. This pilot study examined the accuracy and efficiency of dental hygiene students' indirect vision skills while using traditional safety lenses and magnification lenses. The sample was comprised of 14 students in their final semester of a dental hygiene program. A crossover study approach was utilized, with each participant randomly assigned to a specific order of eyewear. The study included evaluation of each participant taking part in 2 separate clinical sessions. During the first session, each participant completed a clinical exercise on a dental manikin marked with 15 dots throughout the oral cavity while wearing the randomly as signed eyewear, and then completed a similar exercise on a differently marked dental manikin while wearing the randomly assigned eyewear. This procedure was repeated at a second clinical session, however, the dental manikin and eyewear pairings were reversed. Accuracy was measured on the number of correctly identified dots and efficiency was measured by the time it took to identify the dots. Perceptions of the participants' use of magnification lenses and the participants' opinion of the use of magnification lenses in a dental hygiene curriculum were evaluated using a questionnaire. Comparing the mean of the efficiency scores, students are more efficient at identifying indirect vision points with the use of magnification lenses (3 minutes, 36 seconds) than with traditional safety lenses (3 minutes, 56 seconds). Comparing the measurement of accuracy, students are more accurate at identifying indirect vision points with traditional safety lenses (84%) as com pared to magnification lenses (79%). Overall, the students report ed an increased quality of dental hygiene treatment provided in the clinical setting and an improved clinical posture while treating patients with the use of magnification lenses

Tear exchange and contact lenses: a review.

PubMed

Muntz, Alex; Subbaraman, Lakshman N; Sorbara, Luigina; Jones, Lyndon

2015-01-01

Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. Copyright © 2014 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

Does correcting astigmatism with toric lenses improve driving performance?

PubMed

Cox, Daniel J; Banton, Thomas; Record, Steven; Grabman, Jesse H; Hawkins, Ronald J

2015-04-01

Driving is a vision-based activity of daily living that impacts safety. Because visual disruption can compromise driving safety, contact lens wearers with astigmatism may pose a driving safety risk if they experience residual blur from spherical lenses that do not correct their astigmatism or if they experience blur from toric lenses that rotate excessively. Given that toric lens stabilization systems are continually improving, this preliminary study tested the hypothesis that astigmats wearing toric contact lenses, compared with spherical lenses, would exhibit better overall driving performance and driving-specific visual abilities. A within-subject, single-blind, crossover, randomized design was used to evaluate driving performance in 11 young adults with astigmatism (-0.75 to -1.75 diopters cylinder). Each participant drove a highly immersive, virtual reality driving simulator (210 degrees field of view) with (1) no correction, (2) spherical contact lens correction (ACUVUE MOIST), and (3) toric contact lens correction (ACUVUE MOIST for Astigmatism). Tactical driving skills such as steering, speed management, and braking, as well as operational driving abilities such as visual acuity, contrast sensitivity, and foot and arm reaction time, were quantified. There was a main effect for type of correction on driving performance (p = 0.05). Correction with toric lenses resulted in significantly safer tactical driving performance than no correction (p < 0.05), whereas correction with spherical lenses did not differ in driving safety from no correction (p = 0.118). Operational tests differentiated corrected from uncorrected performance for both spherical (p = 0.008) and toric (p = 0.011) lenses, but they were not sensitive enough to differentiate toric from spherical lens conditions. Given previous research showing that deficits in these tactical skills are predictive of future real-world collisions, these preliminary data suggest that correcting low to moderate

Contact Lenses Wettability In Vitro: Effect of Surface-Active Ingredients

PubMed Central

Lin, Meng C.; Svitova, Tatyana F.

2010-01-01

Purpose To investigate the release of surface-active agents (surfactants) from unworn soft contact lenses and their influence on the lens surface wettability in vitro. Methods Surface tension (ST) of blister pack solutions was measured by pendant-drop technique. STs at the air-aqueous interface and contact angles (CAs) of four conventional and seven silicone hydrogel (SiH) soft contact lenses (SCLs) were evaluated in a dynamic-cycling regime using a modified captive-bubble tensiometer-goniometer. Measurements were performed immediately after removal from blister packs, and after soaking in a glass vial filled with a surfactant-free solution, which was replaced daily for one week. Lens surface wettability was expressed as adhesion energy (AE) according to Young’s equation. Results STs of all blister pack solutions were lower than the reference ST of pure water (72.5 mN/m), indicating the presence of surfactants. When lenses were depleted of surfactants by soaking, the STs of all studied lenses and advancing CAs of selected lenses increased (p < 0.001). Receding CAs of all studied lenses were 12° ± 5° and were not affected by the presence of surfactants. For most of the conventional lenses, the surface wettability was largely dependent on surfactants, and reduced significantly after surfactant depletion. In contrast, most SiH lenses exhibited stable and self-sustained surface wettability in vitro. Conclusions The manufacturer-added surfactants affected wetting properties of all studied SCLs, although to different degrees. PMID:20400924

Parabolic crossed planar polymeric x-ray lenses

NASA Astrophysics Data System (ADS)

Nazmov, V.; Reznikova, E.; Mohr, J.; Saile, V.; Vincze, L.; Vekemans, B.; Bohic, S.; Somogyi, A.

2011-01-01

The principles of design and manufacturing of the polymer planar x-ray lenses focusing in one and two directions, as well as the peculiarities of optical behaviors and the results of the lens test are reported in this paper. The methods of electron and deep x-ray lithography used in lens manufacturing allow the manufacture of ten or more x-ray lenses on one substrate; the lenses show focal lengths down to several centimeters for photon energies between 5 and 40 keV. The measured focus size was 105 nm for a linear lens with an intensity gain of about 407, and 300 × 770 nm for a crossed lens with an intensity gain of 6470.

Exploring cosmic origins with CORE: Gravitational lensing of the CMB

NASA Astrophysics Data System (ADS)

Challinor, A.; Allison, R.; Carron, J.; Errard, J.; Feeney, S.; Kitching, T.; Lesgourgues, J.; Lewis, A.; Zubeldía, Í.; Achucarro, A.; Ade, P.; Ashdown, M.; Ballardini, M.; Banday, A. J.; Banerji, R.; Bartlett, J.; Bartolo, N.; Basak, S.; Baumann, D.; Bersanelli, M.; Bonaldi, A.; Bonato, M.; Borrill, J.; Bouchet, F.; Boulanger, F.; Brinckmann, T.; Bucher, M.; Burigana, C.; Buzzelli, A.; Cai, Z.-Y.; Calvo, M.; Carvalho, C.-S.; Castellano, G.; Chluba, J.; Clesse, S.; Colantoni, I.; Coppolecchia, A.; Crook, M.; d'Alessandro, G.; de Bernardis, P.; de Gasperis, G.; De Zotti, G.; Delabrouille, J.; Di Valentino, E.; Diego, J.-M.; Fernandez-Cobos, R.; Ferraro, S.; Finelli, F.; Forastieri, F.; Galli, S.; Genova-Santos, R.; Gerbino, M.; González-Nuevo, J.; Grandis, S.; Greenslade, J.; Hagstotz, S.; Hanany, S.; Handley, W.; Hernandez-Monteagudo, C.; Hervías-Caimapo, C.; Hills, M.; Hivon, E.; Kiiveri, K.; Kisner, T.; Kunz, M.; Kurki-Suonio, H.; Lamagna, L.; Lasenby, A.; Lattanzi, M.; Liguori, M.; Lindholm, V.; López-Caniego, M.; Luzzi, G.; Maffei, B.; Martinez-González, E.; Martins, C. J. A. P.; Masi, S.; Matarrese, S.; McCarthy, D.; Melchiorri, A.; Melin, J.-B.; Molinari, D.; Monfardini, A.; Natoli, P.; Negrello, M.; Notari, A.; Paiella, A.; Paoletti, D.; Patanchon, G.; Piat, M.; Pisano, G.; Polastri, L.; Polenta, G.; Pollo, A.; Poulin, V.; Quartin, M.; Remazeilles, M.; Roman, M.; Rubino-Martin, J.-A.; Salvati, L.; Tartari, A.; Tomasi, M.; Tramonte, D.; Trappe, N.; Trombetti, T.; Tucker, C.; Valiviita, J.; Van de Weijgaert, R.; van Tent, B.; Vennin, V.; Vielva, P.; Vittorio, N.; Young, K.; Zannoni, M.

2018-04-01

Lensing of the cosmic microwave background (CMB) is now a well-developed probe of the clustering of the large-scale mass distribution over a broad range of redshifts. By exploiting the non-Gaussian imprints of lensing in the polarization of the CMB, the CORE mission will allow production of a clean map of the lensing deflections over nearly the full-sky. The number of high-S/N modes in this map will exceed current CMB lensing maps by a factor of 40, and the measurement will be sample-variance limited on all scales where linear theory is valid. Here, we summarise this mission product and discuss the science that will follow from its power spectrum and the cross-correlation with other clustering data. For example, the summed mass of neutrinos will be determined to an accuracy of 17 meV combining CORE lensing and CMB two-point information with contemporaneous measurements of the baryon acoustic oscillation feature in the clustering of galaxies, three times smaller than the minimum total mass allowed by neutrino oscillation measurements. Lensing has applications across many other science goals of CORE, including the search for B-mode polarization from primordial gravitational waves. Here, lens-induced B-modes will dominate over instrument noise, limiting constraints on the power spectrum amplitude of primordial gravitational waves. With lensing reconstructed by CORE, one can "delens" the observed polarization internally, reducing the lensing B-mode power by 60 %. This can be improved to 70 % by combining lensing and measurements of the cosmic infrared background from CORE, leading to an improvement of a factor of 2.5 in the error on the amplitude of primordial gravitational waves compared to no delensing (in the null hypothesis of no primordial B-modes). Lensing measurements from CORE will allow calibration of the halo masses of the tens of thousands of galaxy clusters that it will find, with constraints dominated by the clean polarization-based estimators. The 19

Effect of Yellow-Tinted Lenses on Visual Attributes Related to Sports Activities

PubMed Central

Kohmura, Yoshimitsu; Murakami, Shigeki; Aoki, Kazuhiro

2013-01-01

The purpose of this study was to clarify the effect of colored lenses on visual attributes related to sports activities. The subjects were 24 students (11 females, 13 males; average age 21.0 ±1.2 years) attending a sports university. Lenses of 5 colors were used: colorless, light yellow, dark yellow, light gray, and dark gray. For each lens, measurements were performed in a fixed order: contrast sensitivity, dynamic visual acuity, depth perception, hand-eye coordination and visual acuity and low-contrast visual acuity. The conditions for the measurements of visual acuity and low-contrast visual acuity were in the order of Evening, Evening+Glare, Day, and Day+Glare. There were no significant differences among lenses in dynamic visual acuity and depth perception. For hand-eye coordination, time was significantly shorter with colorless than dark gray lenses. Contrast sensitivity was significantly higher with colorless, light yellow, and light gray lenses than with dark yellow and dark gray lenses. The low-contrast visual acuity test in the Day+Glare condition showed no significant difference among the lenses. In the Evening condition, low-contrast visual acuity was significantly higher with colorless and light yellow lenses than with dark gray lenses, and in the Evening+Glare condition, low-contrast visual acuity was significantly higher with colorless lenses than with the other colors except light yellow. Under early evening conditions and during sports activities, light yellow lenses do not appear to have an adverse effect on visual attributes. PMID:23717352

Solid explosive plane-wave lenses pressed-to-shape with dies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olinger, B.

2007-11-01

Solid-explosive plane-wave lenses 1", 2" and 4¼" in diameter have been mass-produced from components pressed-to-shape with aluminum dies. The method used to calculate the contour between the solid plane-wave lens components pressed-to-shape with the dies is explained. The steps taken to press, machine, and assemble the lenses are described. The method of testing the lenses, the results of those tests, and the corrections to the dies are reviewed. The work on the ½", 8", and 12" diameter lenses is also discussed.

Are Disposable and Standard Gonioscopy Lenses Comparable?

PubMed

Lee, Bonny; Szirth, Bernard C; Fechtner, Robert D; Khouri, Albert S

2017-04-01

Gonioscopy is important in the evaluation and treatment of glaucoma. With increased scrutiny of acceptable sterilization processes for health care instruments, disposable gonioscopy lenses have recently been introduced. Single-time use lenses are theorized to decrease infection risk and eliminate the issue of wear and tear seen on standard, reusable lenses. However, patient care would be compromised if the quality of images produced by the disposable lens were inferior to those produced by the reusable lens. The purpose of this study was to compare the quality of images produced by disposable versus standard gonioscopy lenses. A disposable single mirror lens (Sensor Medical Technology) and a standard Volk G-1 gonioscopy lens were used to image 21 volunteers who were prospectively recruited for the study. Images of the inferior and temporal angles of each subject's left eye were acquired using a slit-lamp camera through the disposable and standard gonioscopy lens. In total, 74 images were graded using the Spaeth gonioscopic system and for clarity and quality. Clarity was scored as 1 or 2 and defined as either (1) all structures perceived or (2) all structures not perceived. Quality was scored as 1, 2, or 3, and defined as (1) all angle landmarks clear and well focused, (2) some angle landmarks clear, others blurred, or (3) angle landmarks could not be ascertained. The 74 images were divided into images taken with the disposable single mirror lens and images taken with the standard Volk G-1 gonioscopy lens. The clarity and quality scores for each of these 2 image groups were averaged and P-values were calculated. Average quality of images produced with the standard lens was 1.46±0.56 compared with 1.54±0.61 for those produced with the disposable lens (P=0.55). Average clarity of images produced with the standard lens was 1.47±0.51 compared with 1.49±0.51 (P=0.90) with the disposable lens. We conclude that there is no significant difference in quality of images

Fluid Lensing and Applications to Remote Sensing of Aquatic Environments

NASA Technical Reports Server (NTRS)

Chirayath, Ved

2017-01-01

The use of fluid lensing technology on UAVs is presented as a novel means for 3D imaging of aquatic ecosystems from above the water's surface at the centimeter scale. Preliminary results are presented from airborne fluid lensing campaigns conducted over the coral reefs of Ofu Island, American Samoa (2013) and the stromatolite reefs of Shark Bay, Western Australia (2014), covering a combined area of 15km2. These reef ecosystems were revealed with centimetre-scale 2D resolution, and an accompanying 3D bathymetry model was derived using fluid lensing, Structure from Motion and UAV position data. Data products were validated from in-situ survey methods including underwater calibration targets, depth measurements and millimetre-scale high-dynamic range gigapixel photogrammetry. Fluid lensing is an experimental technology that uses water transmitting wavelengths to passively image underwater objects at high-resolution by exploiting time-varying optical lensing events caused by surface waves. Fluid lensing data are captured from low-altitude, cost-effective electric UAVs to achieve multispectral imagery and bathymetry models at the centimetre scale over regional areas. As a passive system, fluid lensing is presently limited by signal-to-noise ratio and water column inherent optical properties to approximately 10 m depth over visible wavelengths in clear waters. The datasets derived from fluid lensing present the first centimetre-scale images of a reef acquired from above the ocean surface, without wave distortion. The 3D multispectral data distinguish coral, fish and invertebrates in American Samoa, and reveal previously undocumented, morphologically distinct, stromatolite structures in Shark Bay. These findings suggest fluid lensing and multirotor electric drones represent a promising advance in the remote sensing of aquatic environments at the centimetre scale, or 'reef scale' relevant to the conservation of reef ecosystems. Pending further development and validation of

Second-line rescue triple therapy with levofloxacin after failure of non-bismuth quadruple "sequential" or "concomitant" treatment to eradicate H. pylori infection.

PubMed

Gisbert, Javier P; Molina-Infante, Javier; Marin, Alicia C; Vinagre, Gemma; Barrio, Jesus; McNicholl, Adrian Gerald

2013-06-01

Non-bismuth quadruple "sequential" and "concomitant" regimens, including a proton pump inhibitor (PPI), amoxicillin, clarithromycin and a nitroimidazole, are increasingly used as first-line treatments for Helicobacter pylori infection. Eradication with rescue regimens may be challenging after failure of key antibiotics such as clarithromycin and nitroimidazoles. To evaluate the efficacy and tolerability of a second-line levofloxacin-containing triple regimen (PPI-amoxicillin-levofloxacin) in the eradication of H. pylori after non-bismuth quadruple-containing treatment failure. prospective multicenter study. in whom a non-bismuth quadruple regimen, administered either sequentially (PPI + amoxicillin for 5 days followed by PPI + clarithromycin + metronidazole for 5 more days) or concomitantly (PPI + amoxicillin + clarithromycin + metronidazole for 10 days) had previously failed. levofloxacin (500 mg b.i.d.), amoxicillin (1 g b.i.d.) and PPI (standard dose b.i.d.) for 10 days. eradication was confirmed with (13)C-urea breath test 4-8 weeks after therapy. Compliance and tolerance: compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by means of a questionnaire. 100 consecutive patients were included (mean age 50 years, 62% females, 12% peptic ulcer and 88% dyspepsia): 37 after "sequential", and 63 after "concomitant" treatment failure. All patients took all medications correctly. Overall, per-protocol and intention-to-treat H. pylori eradication rates were 75.5% (95% CI 66-85%) and 74% (65-83%). Respective intention-to-treat cure rates for "sequential" and "concomitant" failure regimens were 74.4% and 71.4%, respectively. Adverse effects were reported in six (6%) patients; all of them were mild. Ten-day levofloxacin-containing triple therapy constitutes an encouraging second-line strategy in patients with previous non-bismuth quadruple "sequential" or "concomitant" treatment failure.

Searching for massive clusters in weak lensing surveys

NASA Astrophysics Data System (ADS)

Hamana, Takashi; Takada, Masahiro; Yoshida, Naoki

2004-05-01

We explore the ability of weak lensing surveys to locate massive clusters. We use both analytic models of dark matter haloes and mock weak lensing surveys generated from a large cosmological N-body simulation. The analytic models describe the average properties of weak lensing haloes and predict the number counts, enabling us to compute an effective survey selection function. We argue that the detectability of massive haloes depends not only on the halo mass but also strongly on the redshift where the halo is located. We test the model prediction for the peak number counts in weak lensing mass maps against mock numerical data, and find that the noise resulting from intrinsic galaxy ellipticities causes a systematic effect which increases the peak counts. We develop a correction scheme for the systematic effect in an empirical manner, and show that, after correction, the model prediction agrees well with the mock data. The mock data is also used to examine the completeness and efficiency of the weak lensing halo search by fully taking into account the noise and the projection effect by large-scale structures. We show that the detection threshold of S/N = 4 ~ 5 gives an optimal balance between completeness and efficiency. Our results suggest that, for a weak lensing survey with a galaxy number density of ng= 30 arcmin-2 with a mean redshift of z= 1, the mean number of haloes which are expected to cause lensing signals above S/N = 4 is Nhalo(S/N > 4) = 37 per 10 deg2, whereas 23 of the haloes are actually detected with S/N > 4, giving the effective completeness as good as 63 per cent. Alternatively, the mean number of peaks in the same area is Npeak= 62 for a detection threshold of S/N = 4. Among the 62 peaks, 23 are caused by haloes with the expected peak height S/N > 4, 13 result from haloes with 3 < S/N < 4 and the remaining 26 peaks are either the false peaks caused by the noise or haloes with a lower expected peak height. Therefore the contamination rate is 44

Characterization and Modeling of Dual Stage Quadruple Pass Configurations

NASA Astrophysics Data System (ADS)

Sellami, M.; Sellami, A.; Berrah, S.

In this paper, the proposed system achieves a gain of 62dBs. It employs a dual-stage (DS) to enhance the amplification and a tunable band-pass filter (TBF) to filter out the backward amplified spontaneous emission (ASE) that degrades the signal amplification at the input end of the EDFA. The technique there by reduces the effect of ASE self-saturation [1]. This configuration is also useful in reducing the sensitivity of the EDFA to extra strenuous reflections caused by imperfections of the splices and other optical components [2]. as well as improving noise figure and gain. The experimental work will build up by using the active component Silica based EDF (Si-EDF) in Dual Stage Quadruple Pass (DSQP) configuration. By using Tunable Band pass Filter (TBF) in DSQP between the port 1 and port 2 of circulators (CRT2, CRT3) to filter out the unwanted ASE.

Electrical quadruple hysteresis in Pd-doped vanadium pentoxide nanowires due to water adsorption

PubMed Central

Kim, Byung Hoon; Oh, Soon-Young; Yu, Han Young; Hong, Won G; Yun, Yong Ju; Kim, Yark Yeon; Kim, Hae Jin

2010-01-01

Humidity-dependent current–voltage (I–V) characteristics of Pd-doped vanadium pentoxide nanowires (Pd-VONs) were investigated. Electrical quadruple hysteresis (QH) was observed and attributed to the large amount of water molecules adsorbed on the nanowires. Using QH in Pd-VONs, the reaction of water with PdO was interpreted as the water molecules are desorbed and then dissociated with increasing bias voltage. Owing to the dissociated H+ and OH− ions, PdO is reduced and oxidized. As a result, water molecules recombine as the bias voltage is decreased. PMID:27877370

Gravitational Lenses and the Structure and Evolution of Galaxies

NASA Technical Reports Server (NTRS)

Kochanek, Christopher

2003-01-01

The grant has supported the completion of 16 papers and 4 conference proceedings to date. During the first year of the project we completed five papers, each of which represents a new direction in the theory and interpretation of gravitational lenses. In the first paper, "The Importance of Einstein Rings", we developed the first theory for the formation and structure of the Einstein rings formed by lensing extended sources like the host galaxies of quasar and radio sources. We applied the theory to three lenses with lensed host galaxies. For the time delay lens PG 1115+080 we found that the structure of the Einstein ring ruled out models of the gravitational potential which permitted a large Hubble constant (70 km/s Mpc). In the second paper, :Cusped Mass Models Of Gravitational Lenses", we introduced a new class of lens models where the central density is characterized by a cusp ( rho proportional to tau(sup -gamma), 1 less than gamma less than 2) as in most modern models and theories of galaxies rather than a finite core radius. In the third paper, "Global Probes of the Impact of Baryons on Dark Matter Halos", we made the first globally consistent models for the separation distribution of gravitational lenses including both galaxy and cluster lenses. We show that the key physics for the origin of the sharp separation cutoff in the separation distribution near 3 arc sec is the effect of the cooling baryons in galaxies on the density structure of the system.

Material properties that predict preservative uptake for silicone hydrogel contact lenses.

PubMed

Green, J Angelo; Phillips, K Scott; Hitchins, Victoria M; Lucas, Anne D; Shoff, Megan E; Hutter, Joseph C; Rorer, Eva M; Eydelman, Malvina B

2012-11-01

To assess material properties that affect preservative uptake by silicone hydrogel lenses. We evaluated the water content (using differential scanning calorimetry), effective pore size (using probe penetration), and preservative uptake (using high-performance liquid chromatography with spectrophotometric detection) of silicone and conventional hydrogel soft contact lenses. Lenses grouped similarly based on freezable water content as they did based on total water content. Evaluation of the effective pore size highlighted potential differences between the surface-treated and non-surface-treated materials. The water content of the lens materials and ionic charge are associated with the degree of preservative uptake. The current grouping system for testing contact lens-solution interactions separates all silicone hydrogels from conventional hydrogel contact lenses. However, not all silicone hydrogel lenses interact similarly with the same contact lens solution. Based upon the results of our research, we propose that the same material characteristics used to group conventional hydrogel lenses, water content and ionic charge, can also be used to predict uptake of hydrophilic preservatives for silicone hydrogel lenses. In addition, the hydrophobicity of silicone hydrogel contact lenses, although not investigated here, is a unique contact lens material property that should be evaluated for the uptake of relatively hydrophobic preservatives and tear components.

Drug delivery through soft contact lenses.

PubMed Central

Jain, M. R.

1988-01-01

Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours. PMID:3349016

Si/SiGe quadruple quantum dots with direct barrier gates

NASA Astrophysics Data System (ADS)

Ward, Daniel; Gamble, John; Foote, Ryan; Savage, Donald; Lagally, Max; Coppersmith, Susan; Eriksson, Mark

2014-03-01

We have fabricated a quadruple quantum dot in a Si/SiGe heterostructure with the aim of demonstrating a two-qubit quantum gate. This device makes use of direct barrier gates, in which individual gates are placed directly over the quantum dots and tunnel barriers. This design enables rational control of both energies and tunnel rates in coupled quantum dots. In this talk we discuss the design, fabrication, and initial characterization of the device. This work was supported in part by ARO (W911NF-12-0607), NSF (DMR-1206915), and the United States Department of Defense. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressly or implied, of the US Government.

Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses.

PubMed

Hsu, Kuan-Hui; de la Jara, Percy Lazon; Ariyavidana, Amali; Watling, Jason; Holden, Brien; Garrett, Qian; Chauhan, Anuj

2015-03-01

To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness. Profiles of the release of osmoprotectant betaine and moisturizing agent dexpanthenol from senofilcon A and narafilcon B contact lenses were determined in vitro under sink conditions. Both types of lenses were also infused with vitamin E to increase the duration of drug release due to the formation of the vitamin E diffusion barriers in the lenses. The release profiles from vitamin E-infused lenses were compared with those from the control lenses. Both dexpanthenol and betaine are released from commercial silicone hydrogel lenses for only about 10 min. Vitamin E loadings into contact lenses at about 20-23% can increase the release times to about 10 h, which is about 60 times larger compared to the control unmodified lenses. Vitamin E-loaded silicone hydrogel contact lenses released betaine and dexpanthenol in a controlled fashion.

Reconstruction of cluster masses using particle based lensing

NASA Astrophysics Data System (ADS)

Deb, Sanghamitra

Clusters of galaxies are among the richest astrophysical data systems, but to truly understand these systems, we need a detailed study of the relationship between observables and the underlying cluster dark matter distribution. Gravitational lensing is the most direct probe of dark matter, but many mass reconstruction techniques assume that cluster light traces mass, or combine different lensing signals in an ad hoc way. In this talk, we will describe "Particle Based Lensing" (PBL), a new method for cluster mass reconstruction, that avoids many of the pitfalls of previous techniques. PBL optimally combines lensing information of varying signal-to-noise, and makes no assumptions about the relationship between mass and light. We will describe mass reconstructions in three very different, but very illuminating cluster systems: the "Bullet Cluster" (lE 0657-56), A901/902 and A1689. The "Bullet Cluster" is a system of merging clusters made famous by the first unambiguous lensing detection of dark matter. A901/902 is a multi-cluster system with four peaks, and provides an ideal laboratory for studying cluster interaction. We are particularly interested in measuring and correlating the dark matter clump ellipticities. A1689 is one of the richest clusters known, and has significant substructure at the core. It is also my first exercise in optimally combining weak and strong gravitational lensing in a cluster reconstruction. We find that the dark matter distribution is significantly clumpier than indicated by X-ray maps of the gas. We conclude by discussing various potential applications of PBL to existing and future data.

First fluorescent sensor for fluoride based on 2-ureido-4[1H]-pyrimidinone quadruple hydrogen-bonded AADD supramolecular assembly.

PubMed

Zhao, Yao-Peng; Zhao, Chun-Chang; Wu, Li-Zhu; Zhang, Li-Ping; Tung, Chen-Ho; Pan, Yuan-Jiang

2006-03-03

A simple, highly selective, neutral, fluorescent sensor for fluoride anions is reported. It is based on 2-ureido-4[1H]-pyrimidinone quadruple hydrogen-bonded AADD supramolecular assembly, and its assembling and disassembling processes are also able to respond to external stimuli reversibly.

Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses.

PubMed

Selan, Laura; Palma, Stefano; Scoarughi, Gian Luca; Papa, Rosanna; Veeh, Richard; Di Clemente, Daniele; Artini, Marco

2009-01-01

To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa. Laboratory investigation. Biofilm formation on colonized test lenses was evaluated with confocal microscopy and in vitro antibiotic susceptibility assays. The results of the latter assays were compared with those performed on planktonic cultures of the same organism. For both microorganisms, sessile colonies on silicone-hydrogel and pHEMA lenses displayed lower antibiotic susceptibility than their planktonic counterparts. In contrast, the susceptibility of cultures growing on PC-C lenses was comparable with that for planktonic cultures. In particular, minimum inhibitory concentration for Tazocin (piperacillin plus tazobactam; Wyeth Pharmaceuticals, Aprilia, Italy; S. epidermidis) and gentamicin (P. aeruginosa) was identical, either in the presence of PC-C support or in planktonic cultures (Tazocin, lenses (0.4 mug/ml) with respect to planktonic cultures (0.2 mug/ml). Confocal microscopy of lenses colonized for 24 hours with P. aeruginosa green fluorescent protein-expressing cells revealed a sessile colonization on silicone-hydrogel lens and a few isolated bacterial cells scattered widely over the surface of the PC-C lens. An increase in antibiotic susceptibility of bacterial cultures was associated with diminished bacterial adhesion. Our results indicate that PC-C lenses seem to be more resistant than silicone-hydrogel and pHEMA lenses to bacterial adhesion and colonization. This feature may facilitate their disinfection.

Gravitational lensing by a smoothly variable surface mass density

NASA Technical Reports Server (NTRS)

Paczynski, Bohdan; Wambsganss, Joachim

1989-01-01

The statistical properties of gravitational lensing due to smooth but nonuniform distributions of matter are considered. It is found that a majority of triple images had a parity characteristic for 'shear-induced' lensing. Almost all cases of triple or multiple imaging were associated with large surface density enhancements, and lensing objects were present between the images. Thus, the observed gravitational lens candidates for which no lensing object has been detected between the images are unlikely to be a result of asymmetric distribution of mass external to the image circle. In a model with smoothly variable surface mass density, moderately and highly amplified images tended to be single rather than multiple. An opposite trend was found in models which had singularities in the surface mass distribution.

Consequences of wear interruption for discomfort with contact lenses.

PubMed

Papas, Eric B; Tilia, Daniel; Tomlinson, Daniel; Williams, Josh; Chan, Eddy; Chan, Jason; Golebiowski, Blanka

2014-01-01

To establish whether increased end-of-day discomfort during soft contact lens wear is associated with short-term changes occurring to the lens itself. Twenty-seven subjects wore hydrogel lenses (Focus Dailies; Alcon) bilaterally for 10 hours on two separate days. Comfort was reported using 1-100 numerical rating scales (1 = intolerable discomfort, 100 = lens cannot be felt). Day 1 ratings were taken before lens insertion and at 0.05, 5, and 10 hours post-insertion. Day 2 ratings occurred at similar times, but lenses were removed after the 5-hour assessment and either reinserted (n = 14) or newly replaced (n = 12). An additional rating was taken 5 minutes after re-insertion. Wear then continued to the 10-hour point. In a separate study, 24 different subjects repeated these procedures using a silicone hydrogel lens (AirOptix Aqua; Alcon) with wear taking place on 3 days to permit lens replacement to be with existing as well as new lenses in all subjects. For hydrogel lenses, comfort scores (mean ± 95% CI) reported after 10 hours were 79.4 ± 8.3 when lenses were worn un-replaced, compared with 73.2 ± 9.2 for replacement with the existing lens. When replacement was with a brand new lens, the corresponding values were 72.9 ± 10.9 (un-replaced) versus 69.2 ± 12.8 (new lens replacement). For silicone hydrogel lenses, 10-hour comfort was 90.3 ± 3.2 (un-replaced) versus 92.2 ± 2.9 (replacement with existing lens) versus 90.0 ± 3.3 (replacement with new lens). Differences between replacement conditions were not significant in any case (analysis of variance, p > 0.05). Final comfort was not influenced by replacing lenses midway through the wearing period. Comfort decrements experienced by users of these daily contact lenses towards the later part of the wearing period are not caused by changes occurring to the lenses on this time scale. Possible alternative etiological factors include a fatigue-like response in one or more ocular tissues or stimulation of ocular

Lathe-cut hydrophilic contact lenses: report of 100 clinical cases.

PubMed

Espy, J W

1978-10-01

In a review of the literature, it became apparent that there were very few articles describing the advantages, as well as the fitting techniques, of lathe-cut hydrophilic contact lenses. Few practitioners, including those who fit other types of hydrophilic lenses and hard lenses, have had any experience with this lens, and considerable interest has been generated by fragmentary reports of good results. This paper describes in detail the geometry of the first lathe-cut hydrophilic lens approved by the Federal Drug Administration, the fitting methods utilizing trial lenses, and the results of 100 patients successfully fitted.

Large-acceptance diamond planar refractive lenses manufactured by laser cutting.

PubMed

Polikarpov, Maxim; Snigireva, Irina; Morse, John; Yunkin, Vyacheslav; Kuznetsov, Sergey; Snigirev, Anatoly

2015-01-01

For the first time, single-crystal diamond planar refractive lenses have been fabricated by laser micromachining in 300 µm-thick diamond plates which were grown by chemical vapour deposition. Linear lenses with apertures up to 1 mm and parabola apex radii up to 500 µm were manufactured and tested at the ESRF ID06 beamline. The large acceptance of these lenses allows them to be used as beam-conditioning elements. Owing to the unsurpassed thermal properties of single-crystal diamond, these lenses should be suitable to withstand the extreme flux densities expected at the planned fourth-generation X-ray sources.

Recent experience with design and manufacture of cine lenses

NASA Astrophysics Data System (ADS)

Thorpe, Michael D.; Dalzell, Kristen E.

2015-09-01

Modern cine lenses require a high degree of aberration correction over a large and ever expanding image size. At low to medium volume production levels, these highly corrected designs also require a workable tolerance set and compensation scheme for successful manufacture. In this paper we discuss the design and manufacture of cine lenses with reference to current designs both internal and in the patent literature and some experience in design, tolerancing and manufacturing these lenses in medium volume production.

Oxygen, water, and sodium chloride transport in soft contact lenses materials.

PubMed

Gavara, Rafael; Compañ, Vicente

2017-11-01

Oxygen permeability, diffusion coefficient of the sodium ions and water flux and permeability in different conventional hydrogel (Hy) and silicone-hydrogel (Si-Hy) contact lenses have been measured experimentally. The results showed that oxygen permeability and transmissibility requirements of the lens have been addressed through the use of siloxane containing hydrogels. In general, oxygen and sodium chloride permeability values increased with the water content of the lens but there was a percolation phenomenon from a given value of water uptake mainly in the Si-Hy lenses which appeared to be related with the differences between free water and bound water contents. The increase of ion permeability with water content did not follow a unique trend indicating a possible dependence of the chemical structure of the polymer and character ionic and non-ionic of the lens. Indeed, the salt permeability values for silicone hydrogel contact lenses were one order of magnitude below those of conventional hydrogel contact lenses, which can be explained by a diffusion of sodium ions occurring only through the hydrophilic channels. The increase of the ionic permeability in Si-Hy materials may be due to the confinement of ions in nanoscale water channels involving possible decreased degrees of freedom for diffusion of both water and ions. In general, ionic lenses presented values of ionic permeability and diffusivity higher than most non-ionic lenses. The tortuosity of the ionic lenses is lower than the non-ionic Si-Hy lenses. Frequency 55 and PureVision exhibited the highest water permeability and flux values and, these parameters were greater for ionic Si-Hy lenses than for ionic conventional hydrogel lenses. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2218-2231, 2017. © 2016 Wiley Periodicals, Inc.

Electron Lenses for the Large Hadron Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stancari, Giulio; Valishev, Alexander; Bruce, Roderik

Electron lenses are pulsed, magnetically confined electron beams whose current-density profile is shaped to obtain the desired effect on the circulating beam. Electron lenses were used in the Fermilab Tevatron collider for bunch-by-bunch compensation of long-range beam-beam tune shifts, for removal of uncaptured particles in the abort gap, for preliminary experiments on head-on beam-beam compensation, and for the demonstration of halo scraping with hollow electron beams. Electron lenses for beam-beam compensation are being commissioned in RHIC at BNL. Within the US LHC Accelerator Research Program and the European HiLumi LHC Design Study, hollow electron beam collimation was studied as anmore » option to complement the collimation system for the LHC upgrades. This project is moving towards a technical design in 2014, with the goal to build the devices in 2015-2017, after resuming LHC operations and re-assessing needs and requirements at 6.5 TeV. Because of their electric charge and the absence of materials close to the proton beam, electron lenses may also provide an alternative to wires for long-range beam-beam compensation in LHC luminosity upgrade scenarios with small crossing angles.« less

Ultrastructural evaluation of explanted opacified Hydroview (H60M) intraocular lenses

PubMed Central

Cartwright, Nathaniel E Knox; Mayer, Eric J; McDonald, Brendan M; Skinner, Andrew; Salter, Chris J; Tole, Derek M; Sparrow, John M; Dick, Andrew D; Group, The Bristol IOL Study; Ferguson, David J P

2007-01-01

Aim To describe the ultrastructural appearance of explanted opacified Hydroview H60M intraocular lenses. Methods 14 explanted lenses were examined by scanning electron microscopy, and their appearance compared with a non‐implanted H60M lens from the same time period. Wavelength‐dispersive x ray spectroscopy (WDX) was performed on two opacified lenses. Results Subsurface deposits were seen in all explanted opacified lenses. These deposits broke only onto the surface of more densely opacified lenses. WDX confirmed that the deposits contained both calcium and phosphorous, consistent with their being calcium apatite. Conclusion These findings challenge the widely accepted opinion that H60M intraocular lens opacification begins on the surface of the optic. PMID:16987894

Efficacy and durability of ultraviolet tints in CR-39 ophthalmic lenses.

PubMed

Lee, D Y; Brown, W L; Trachimowicz, R

1997-11-01

Ocular protection from solar ultraviolet (UV) radiation has been emphasized in recent years as a result of the thinning of the ozone layer in the atmosphere. The purpose of this study was to evaluate the absorptive properties of UV tints in CR-39 lenses. We used a spectrophotometer to measure the UV transmittance of three groups of UV tinted CR-39 lenses, including (1) lenses tinted by local optical laboratories: (2) lenses tinted by us, using commercially available dyes: and (3) stock UV lenses that have UV absorptive molecules throughout the lens. We also tested the durability of these tints to daily washing/drying by measuring their UV transmittance characteristics at 3, 6, and 12 months. All the tested lenses absorbed all of the UV-B and at least 99% of UV-A. The durability of these UV tints when exposed to daily washing/drying was excellent: all lenses continued to absorb all of the UV-B and at least 99% of UV-A after 1 year. These data suggest that UV tinted CR-39 lenses provide protection against UV radiation that meets the ANSI Z80.3-1996 Standard for non-prescription sunglasses and fashion eyewear. Furthermore, normal daily washing/drying for 1 year does not cause a significant decrease in the protective effect of the UV tint.

RELICS: Reionization Lensing Cluster Survey

NASA Astrophysics Data System (ADS)

Coe, Dan A.; RELICS Team

2017-01-01

Hubble and Spitzer imaging programs observing galaxy cluster lenses have delivered some of the highest redshift galaxy candidates to date (z ~ 9 - 11, or 540 - 410 Myr after the Big Bang). These magnified galaxies are intrinsically faint, and thus more representative of the sources believed to be primarily responsible for reionization. Magnified galaxies are also observed brightly enough to be prime targets for detailed follow-up study with current and future observatories, including JWST. Building on the successes of CLASH and the Frontier Fields, we have begun RELICS, the Reionization Lensing Cluster Survey. By observing 41 massive clusters for the first time at infrared wavelengths, RELICS will deliver more of the best and brightest high-redshift candidates to the community in time for the November 2017 JWST GO Cycle 1 call for proposals. I will present our early results. I will also discuss prospects for JWST to follow-up known candidates and discover new galaxies at even higher redshifts (z > 11). The discovery efficiency gains from lensing will be even more pronounced at z > 11 if luminosity function faint end slopes are steeper than alpha ~ -2, as suggested by current models and observational extrapolations.

Spatially resolved galactic wind in lensed galaxy RCSGA 032727-132609

NASA Astrophysics Data System (ADS)

Bordoloi, Rongmon; Rigby, Jane R.; Tumlinson, Jason; Bayliss, Matthew B.; Sharon, Keren; Gladders, Michael G.; Wuyts, Eva

2016-05-01

We probe the spatial distribution of outflowing gas along four lines of sight separated by up to 6 kpc in a gravitationally lensed star-forming galaxy at z = 1.70. Using Mg II and Fe II emission and absorption as tracers, we find that the clumps of star formation are driving galactic outflows with velocities of -170 to -250 km s-1. The velocities of Mg II emission are redshifted with respect to the systemic velocities of the galaxy, consistent with being back-scattered. By contrast, the Fe II fluorescent emission lines are either slightly blueshifted or at the systemic velocity of the galaxy. Taken together, the velocity structure of the Mg II and Fe II emission is consistent with arising through scattering in galactic winds. Assuming a thin shell geometry for the outflowing gas, the estimated masses carried out by these outflows are large (≳30-50 M⊙ yr- 1), with mass loading factors several times the star formation rate. Almost 20 per cent to 50 per cent of the blueshifted absorption probably escapes the gravitational potential of the galaxy. In this galaxy, the outflow is `locally sourced', that is, the properties of the outflow in each line of sight are dominated by the properties of the nearest clump of star formation; the wind is not global to the galaxy. The mass outflow rates and the momentum flux carried out by outflows in individual star-forming knots of this object are comparable to that of starburst galaxies in the local Universe.

Spatially Resolved Galactic Wind in Lensed Galaxy RCSGA 032727-132609

NASA Technical Reports Server (NTRS)

Bordoloi, Rongmon; Rigby, Jane R.; Tumlinson, Janson; Bayliss, Matthew B.; Sharon, Keren; Gladders, Michael G.; Wuyts, Eva

2016-01-01

We probe the spatial distribution of outflowing gas along four lines of sight separated by up to 6 kpc in a gravitationally lensed star-forming galaxy at z = 1.70. Using Mg II and Fe II emission and absorption as tracers, we find that the clumps of star formation are driving galactic outflows with velocities of - 170 to - 250 km/s. The velocities of Mg II emission are redshifted with respect to the systemic velocities of the galaxy, consistent with being backscattered. By contrast, the Fe II fluorescent emission lines are either slightly blueshifted or at the systemic velocity of the galaxy. Taken together, the velocity structure of the Mg II and Fe II emission is consistent with arising through scattering in galactic winds. Assuming a thin shell geometry for the outflowing gas, the estimated masses carried out by these outflows are large (approx 30-50 M/yr), with mass loading factors several times the star formation rate. Almost 20 per cent to 50 per cent of the blueshifted absorption probably escapes the gravitational potential of the galaxy. In this galaxy, the outflow is 'locally sourced', that is, the properties of the outflow in each line of sight are dominated by the properties of the nearest clump of star formation; the wind is not global to the galaxy. The mass outflow rates and the momentum flux carried out by outflows in individual star-forming knots of this object are comparable to that of starburst galaxies in the local Universe.

Frustration relieved ferrimagnetism in novel A- and B-site-ordered quadruple perovskite.

PubMed

Chen, Wei-tin; Mizumaki, Masaichiro; Saito, Takashi; Shimakawa, Yuichi

2013-07-28

A novel A- and B-site-ordered quadruple perovskite CaCu3Fe2Sb2O12 was obtained and it shows ferrimagnetism below about 170 K. The B-site Fe spin sublattice adapts a tetrahedral framework in a cubic structure and the Fe(3+)-Fe(3+) antiferromagnetic interaction can result in a geometrical spin frustration as seen in a simple perovskite Ca2FeSbO6. With the introduction of Cu(2+) into the A' site, the antiferromagnetic spin frustration is relieved by the strong Cu(2+)-Fe(3+) interaction, and a ferrimagnetic ordering appears at a much higher temperature than the spin-glass transition temperature.

Strong gravitational lensing statistics as a test of cosmogonic scenarios

NASA Technical Reports Server (NTRS)

Cen, Renyue; Gott, J. Richard, III; Ostriker, Jeremiah P.; Turner, Edwin L.

1994-01-01

Gravitational lensing statistics can provide a direct and powerful test of cosmic structure formation theories. Since lensing tests, directly, the magnitude of the nonlinear mass density fluctuations on lines of sight to distant objects, no issues of 'bias' (of mass fluctuations with respect to galaxy density fluctuations) exist here, although lensing observations provide their own ambiguities of interpretation. We develop numerical techniques for generating model density distributions with the very large spatial dynamic range required by lensing considerations and for identifying regions of the simulations capable of multiple image lensing in a conservative and computationally efficient way that should be accurate for splittings significantly larger than 3 seconds. Applying these techniques to existing standard Cold dark matter (CDM) (Omega = 1) and Primeval Baryon Isocurvature (PBI) (Omega = 0.2) simulations (normalized to the Cosmic Background Explorer Satellite (COBE) amplitude), we find that the CDM model predicts large splitting (greater than 8 seconds) lensing events roughly an order-of-magnitude more frequently than the PBI model. Under the reasonable but idealized assumption that lensing structrues can be modeled as singular isothermal spheres (SIS), the predictions can be directly compared to observations of lensing events in quasar samples. Several large splitting (Delta Theta is greater than 8 seconds) cases are predicted in the standard CDM model (the exact number being dependent on the treatment of amplification bias), whereas none is observed. In a formal sense, the comparison excludes the CDM model at high confidence (essentially for the same reason that CDM predicts excessive small-scale cosmic velocity dispersions.) A very rough assessment of low-density but flat CDM model (Omega = 0.3, Lambda/3H(sup 2 sub 0) = 0.7) indicates a far lower and probably acceptable level of lensing. The PBI model is consistent with, but not strongly tested by, the

Influence of protein deposition on bacterial adhesion to contact lenses.

PubMed

Subbaraman, Lakshman N; Borazjani, Roya; Zhu, Hua; Zhao, Zhenjun; Jones, Lyndon; Willcox, Mark D P

2011-08-01

The aim of the study is to determine the adhesion of Gram positive and Gram negative bacteria onto conventional hydrogel (CH) and silicone hydrogel (SH) contact lens materials with and without lysozyme, lactoferrin, and albumin coating. Four lens types (three SH-balafilcon A, lotrafilcon B, and senofilcon A; one CH-etafilcon A) were coated with lysozyme, lactoferrin, or albumin (uncoated lenses acted as controls) and then incubated in Staphylococcus aureus (Saur 31) or either of two strains of Pseudomonas aeruginosa (Paer 6294 and 6206) for 24 h at 37 °C. The total counts of the adhered bacteria were determined using the H-thymidine method and viable counts by counting the number of colony-forming units on agar media. All three strains adhered significantly lower to uncoated etafilcon A lenses compared with uncoated SH lenses (p < 0.05). Lysozyme coating on all four lens types increased binding (total and viable counts) of Saur 31 (p < 0.05). However, lysozyme coating did not influence P. aeruginosa adhesion (p > 0.05). Lactoferrin coating on lenses increased binding (total and viable counts) of Saur 31 (p < 0.05). Lactoferrin-coated lenses showed significantly higher total counts (p < 0.05) but significantly lower viable counts (p < 0.05) of adhered P. aeruginosa strains. There was a significant difference between the total and viable counts (p < 0.05) that were bound to lactoferrin-coated lenses. Albumin coating of lenses increased binding (total and viable counts) of all three strains (p < 0.05). Lysozyme deposited on contact lenses does not possess antibacterial activity against certain bacterial strains, whereas lactoferrin possess an antibacterial effect against strains of P. aeruginosa.

Invited Review Article: Development of crystal lenses for energetic photons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smither, Robert K.

2014-08-15

This paper follows the development of crystal diffraction lenses designed to focus energetic photons. It begins with the search for a solution to the astrophysics problem of how to detect weak astrophysics sources of gamma rays and x-rays. This led to the basic designs for a lens and to the understanding of basic limitations of lens design. The discussion of the development of crystal diffraction lenses is divided into two parts: lenses using crystals with mosaic structure, and lenses that use crystals with curved crystal planes. This second group divides into two sub-groups: (1) Curved crystals that are used tomore » increase the acceptance angle of the diffraction of a monochromatic beam and to increase the energy bandwidth of the diffraction. (2) Curved crystals used to focus gamma ray beams. The paper describes how these two types of crystals affect the design of the corresponding crystal lenses in different fields: astrophysics, medical imaging, detection of weak, distant, gamma-ray sources, etc. The designs of crystal lenses for these applications are given in enough detail to allow the reader to design a lens for his own application.« less

Lensing bias to CMB polarization measurements of compensated isocurvature perturbations

NASA Astrophysics Data System (ADS)

Heinrich, Chen

2018-01-01

Compensated isocurvature perturbations (CIPs) are opposite spatial fluctuations in the baryon and dark matter (DM) densities. They arise in the curvaton model and some models of baryogenesis. While the gravitational effects of baryon fluctuations are compensated by those of DM, leaving no observable impacts on the cosmic microwave background (CMB) at first order, they modulate the sound horizon at recombination, thereby correlating CMB anisotropies at different multipoles. As a result, CIPs can be reconstructed using quadratic estimators similarly to CMB detection of gravitational lensing. Because of these similarities, however, the CIP estimators are biased with lensing contributions that must be subtracted. These lensing contributions for CMB polarization measurement of CIPs are found to roughly triple the noise power of the total CIP estimator on large scales. In addition, the cross power with temperature and E -mode polarization are contaminated by lensing-ISW (integrated Sachs-Wolfe) correlations and reionization-lensing correlations respectively. For a cosmic-variance-limited temperature and polarization experiment measuring out to multipoles lmax=2500 , the lensing noise raises the detection threshold by a factor of 1.5, leaving a 2.7 σ detection possible for the maximal CIP signal in the curvaton model.

Weak lensing in the Dark Energy Survey

NASA Astrophysics Data System (ADS)

Troxel, Michael

2016-03-01

I will present the current status of weak lensing results from the Dark Energy Survey (DES). DES will survey 5000 square degrees in five photometric bands (grizY), and has already provided a competitive weak lensing catalog from Science Verification data covering just 3% of the final survey footprint. I will summarize the status of shear catalog production using observations from the first year of the survey and discuss recent weak lensing science results from DES. Finally, I will report on the outlook for future cosmological analyses in DES including the two-point cosmic shear correlation function and discuss challenges that DES and future surveys will face in achieving a control of systematics that allows us to take full advantage of the available statistical power of our shear catalogs.

Sub-wavelength Laser Nanopatterning using Droplet Lenses

NASA Astrophysics Data System (ADS)

Duocastella, Martí; Florian, Camilo; Serra, Pere; Diaspro, Alberto

2015-11-01

When a drop of liquid falls onto a screen, e.g. a cell phone, the pixels lying underneath appear magnified. This lensing effect is a combination of the curvature and refractive index of the liquid droplet. Here, the spontaneous formation of such lenses is exploited to overcome the diffraction limit of a conventional laser direct-writing system. In particular, micro-droplets are first laser-printed at user-defined locations on a surface and they are later used as lenses to focus the same laser beam. Under conditions described herein, nanopatterns can be obtained with a reduction in spot size primarily limited by the refractive index of the liquid. This all-optics approach is demonstrated by writing arbitrary patterns with a feature size around 280 nm, about one fourth of the processing wavelength.

The Search for Lensed Supernovae

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-01-01

Type Ia supernovae that have multiple images due to gravitational lensing can provide us with a wealth of information both about the supernovae themselves and about our surrounding universe. But how can we find these rare explosions?Clues from Multiple ImagesWhen light from a distant object passes by a massive foreground galaxy, the galaxys strong gravitational pull can bend the light, distorting our view of the backgroundobject. In severe cases, this process can cause multiple images of the distant object to appear in the foreground lensing galaxy.An illustration of gravitational lensing. Light from the distant supernova is bent as it passes through a giant elliptical galaxy in the foreground, causing multiple images of the supernova to appear to be hosted by the elliptical galaxy. [Adapted from image by NASA/ESA/A. Feild (STScI)]Observations of multiply-imaged Type Ia supernovae (explosions that occur when white dwarfs in binary systems exceed their maximum allowed mass) could answer a number of astronomical questions. Because Type Ia supernovae are standard candles, distant, lensed Type Ia supernovae can be used to extend the Hubble diagram to high redshifts. Furthermore, the lensing time delays from the multiply-imaged explosion can provide high-precision constraints on cosmological parameters.The catch? So far, weve only found one multiply-imaged Type Ia supernova: iPTF16geu, discovered late last year. Were going to need a lot more of them to develop a useful sample! So how do we identify themutiply-imaged Type Ias among the many billions of fleeting events discovered in current and future surveys of transients?Searching for AnomaliesAbsolute magnitudes for Type Ia supernovae in elliptical galaxies. None are expected to be above -20 in the B band, so if we calculate a magnitude for a Type Ia supernova thats larger than this, its probably not hosted by the galaxy we think it is! [Goldstein Nugent 2017]Two scientists from University of California, Berkeley and

Weak gravitational lensing analysis of Sloan Digital Sky Survey data

NASA Astrophysics Data System (ADS)

Mandelbaum, Rachel

Weak gravitational lensing, the distortion of images of distant galaxies due to gravitational deflection of light by more nearby masses, is a powerful tool that can address a wide variety of problems in astrophysics and cosmology. Observation of weak lensing requires large amounts of data since it can only be measured as an average over millions of galaxy shapes. This thesis focuses on lensing-related science that can be addressed using data from the Sloan Digital Sky Survey (SDSS), an excellent source of high-quality data. First, we discuss technical issues related to observing lensing in the data, with a description of our Reglens pipeline and constraints on systematic errors in current data. This is followed by a comparison of an analytical model known as the halo model (which can be used to relate the observed lensing signal to properties of the lens galaxies) against the lensing signal in N-body simulations. After these preliminaries, we address several very different science questions using our reductions of the SDSS data. The first is the question of intrinsic alignments of galaxies (alignments of galaxies on the sky due to local structure), which may be a contaminant for future lensing surveys that seek to determine the cosmological model to high precision. Second, we use a halo model analysis of the lensing signal to determine the relationship between galaxy luminosity, stellar mass, and halo mass, and to measure satellite fractions, all of which can help distinguish between models of galaxy formation. The third application we consider is methodology for the detection of dark matter halo ellipticity, including a first attempt at detecting it with SDSS lensing data, these results may be used to distinguish between cosmological models and learn more about galaxy intrinsic alignments. Finally, we measure the matter distributions around Luminous Red Galaxies (LRGs), which not only teaches us about the properties of these galaxies, but also gives us information

THE SERENDIPITOUS OBSERVATION OF A GRAVITATIONALLY LENSED GALAXY AT z = 0.9057 FROM THE BLANCO COSMOLOGY SURVEY: THE ELLIOT ARC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buckley-Geer, E. J.; Lin, H.; Drabek, E. R.

2011-11-20

We report on the serendipitous discovery in the Blanco Cosmology Survey (BCS) imaging data of a z = 0.9057 galaxy that is being strongly lensed by a massive galaxy cluster at a redshift of z = 0.3838. The lens (BCS J2352-5452) was discovered while examining i- and z-band images being acquired in 2006 October during a BCS observing run. Follow-up spectroscopic observations with the Gemini Multi-Object Spectrograph instrument on the Gemini-South 8 m telescope confirmed the lensing nature of this system. Using weak-plus-strong lensing, velocity dispersion, cluster richness N{sub 200}, and fitting to a Navarro-Frenk-White (NFW) cluster mass density profile,more » we have made three independent estimates of the mass M{sub 200} which are all very consistent with each other. The combination of the results from the three methods gives M{sub 200} = (5.1 {+-} 1.3) Multiplication-Sign 10{sup 14} M{sub Sun }, which is fully consistent with the individual measurements. The final NFW concentration c{sub 200} from the combined fit is c{sub 200} = 5.4{sup +1.4}{sub -1.1}. We have compared our measurements of M{sub 200} and c{sub 200} with predictions for (1) clusters from {Lambda}CDM simulations, (2) lensing-selected clusters from simulations, and (3) a real sample of cluster lenses. We find that we are most compatible with the predictions for {Lambda}CDM simulations for lensing clusters, and we see no evidence based on this one system for an increased concentration compared to {Lambda}CDM. Finally, using the flux measured from the [O II]3727 line we have determined the star formation rate of the source galaxy and find it to be rather modest given the assumed lens magnification.« less

Trend of digital camera and interchangeable zoom lenses with high ratio based on patent application over the past 10 years

NASA Astrophysics Data System (ADS)

Sensui, Takayuki

2012-10-01

Although digitalization has tripled consumer-class camera market scale, extreme reductions in prices of fixed-lens cameras has reduced profitability. As a result, a number of manufacturers have entered the market of the System DSC i.e. digital still camera with interchangeable lens, where large profit margins are possible, and many high ratio zoom lenses with image stabilization functions have been released. Quiet actuators are another indispensable component. Design with which there is little degradation in performance due to all types of errors is preferred for good balance in terms of size, lens performance, and the rate of quality to sub-standard products. Decentering, such as that caused by tilting, sensitivity of moving groups is especially important. In addition, image stabilization mechanisms actively shift lens groups. Development of high ratio zoom lenses with vibration reduction mechanism is confronted by the challenge of reduced performance due to decentering, making control over decentering sensitivity between lens groups everything. While there are a number of ways to align lenses (axial alignment), shock resistance and ability to stand up to environmental conditions must also be considered. Naturally, it is very difficult, if not impossible, to make lenses smaller and achieve a low decentering sensitivity at the same time. 4-group zoom construction is beneficial in making lenses smaller, but decentering sensitivity is greater. 5-group zoom configuration makes smaller lenses more difficult, but it enables lower decentering sensitivities. At Nikon, the most advantageous construction is selected for each lens based on specifications. The AF-S DX NIKKOR 18-200mm f/3.5-5.6G ED VR II and AF-S NIKKOR 28-300mm f/3.5-5.6G ED VR are excellent examples of this.

Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

PubMed

Gu, Xiaobo; Jennings, Jacob D; Snarr, Jason; Chaudhary, Vinod; Pollard, Jacob E; Savage, Paul B

2013-09-17

We provided contact lens hydrogels with an antibacterial innate immune function using nonpeptide mimics of endogenous antimicrobial peptides. Antimicrobial peptide mimics, ceragenins, were prepared for either covalent attachment to hydrogels or for controlled elution from lenses. The lipophilicity of the ceragenins was varied incrementally to provide differing levels of association with hydrophobic domains in lenses. Ceragenin-containing lenses were challenged repeatedly with Staphylococcus aureus or Pseudomonas aeruginosa in nutrient media. Bacterial growth and biofilm formation on lenses were quantified. A ceragenin covalently fixed in lenses effectively inhibited S. aureus biofilm formation on lenses in 10% tryptic soy broth (approximately 3-log reduction), but did not reduce biofilm formation in 100% tryptic soy broth. Ceragenins designed to elute from lenses were incorporated at 1% relative to the dry weight of the lenses. The ceragenin with the optimal lipid content, CSA-138, prevented bacterial colonization of lenses for 15 days with P. aeruginosa and for 30 days with S. aureus (daily exchange of growth media and reinoculation with 10⁶ CFU). Measurement of CSA-138 elution showed that concentrations of the ceragenin never exceeded 5 μg/mL in a 24-hour period and that after 4 days of elution, concentrations dropped to <0.5 μg/mL, while maintaining antibacterial activity. Ceragenin CSA-138 appears well suited for providing an innate immune-like function to abiotic hydrogel contact lenses for extended periods of time. Elution of even low concentrations of CSA-138 (<0.5 μg) is sufficient to eliminate inocula of 10⁶ CFU of S. aureus and P. aeruginosa.

Melimine-Coated Antimicrobial Contact Lenses Reduce Microbial Keratitis in an Animal Model.

PubMed

Dutta, Debarun; Vijay, Ajay K; Kumar, Naresh; Willcox, Mark D P

2016-10-01

To determine the ability of antimicrobial peptide melimine-coated contact lenses to reduce the incidence of microbial keratitis (MK) in a rabbit model of contact lens wear. In vitro antimicrobial activity of melimine-coated contact lenses was determined against Pseudomonas aeruginosa by viable count and a radiolabeled assay. The amount of lipopolysaccharide (LPS) associated with bacteria bound to melimine-coated and control lenses was determined. Ocular swabs from rabbit eyes were collected for assessment of ocular microflora. A rabbit model for MK was developed that used overnight wear of contact lenses colonized by P. aeruginosa in the absence of a corneal scratch. During lens wear, detailed ocular examinations were performed, and the incidence of MK was investigated. Bacteria associated with worn lenses and infected corneas were determined by viable plate count. Inhibition in viable and total P. aeruginosa adhesion by melimine-coated contact lenses was 3.1 log10 and 0.4 log10, respectively. After colonization, the amount of LPS on lenses was approximately the same with or without melimine. Gram-positive bacteria were found in all the ocular swabs followed by fungus (42%). Melimine-coated lens wear was protective and significantly (odds ratio 10.12; P = 0.012) reduced the incidence of P. aeruginosa-driven MK in the rabbit model. The antimicrobial lenses were associated with significantly (P < 0.001) lower ocular scores, indicating improved ocular signs compared with controls. This study showed that contaminated contact lenses can produce MK without corneal epithelial defect in an animal model. Melimine-coated contact lenses reduced the incidence of MK associated with P. aeruginosa in vivo. Development of MK requires viable bacteria adherent to contact lenses, and bacterial debris adherent at the lens surface did not cause keratitis.

Pre-coding assisted generation of a frequency quadrupled optical vector D-band millimeter wave with one Mach-Zehnder modulator.

PubMed

Zhou, Wen; Li, Xinying; Yu, Jianjun

2017-10-30

We propose QPSK millimeter-wave (mm-wave) vector signal generation for D-band based on balanced precoding-assisted photonic frequency quadrupling technology employing a single intensity modulator without an optical filter. The intensity MZM is driven by a balanced pre-coding 37-GHz QPSK RF signal. The modulated optical subcarriers are directly sent into the single ended photodiode to generate 148-GHz QPSK vector signal. We experimentally demonstrate 1-Gbaud 148-GHz QPSK mm-wave vector signal generation, and investigate the bit-error-rate (BER) performance of the vector signals at 148-GHz. The experimental results show that the BER value can be achieved as low as 1.448 × 10 -3 when the optical power into photodiode is 8.8dBm. To the best of our knowledge, it is the first time to realize the frequency-quadrupling vector mm-wave signal generation at D-band based on only one MZM without an optical filter.

Personalized Progressive Addition Lenses: Correlation between Performance and Design.

PubMed

Forkel, Johanne; Reiniger, Jenny Lorén; Muschielok, Adam; Welk, Andrea; Seidemann, Anne; Baumbach, Peter

2017-02-01

A continuous set of personalized designs (design space) for progressive addition lenses (PALs) is investigated. The main goals are (1) to study how the subjects' perception of a personalized design depends on its position in the design space and (2) to compare the performance of personalized PALs to a conventional PAL with a fixed design. In a double-blind study, 51 subjects compared Rodenstock Impression FreeSign 3, which is a family of PALs with a continuously controllable personalized design, and Rodenstock Progressiv Life Free, which is a conventional PAL with a single fixed design. The positions and sizes of viewing zones and the softness of gradients of mean power and astigmatism of personalized lenses were customized to individual viewing preferences. These designs were represented as points in a design space comprising a continuum of PAL designs. Subjective ratings and experimental measurements were used to study viewing zone widths, blur gradient smoothness, amount of distortion, the feeling of safety during motion, and overall wearing comfort. (1) Far viewing zone width (experiments and ratings), near viewing zone width (experiments), blur gradient smoothness, and the amount of distortion (ratings) were significantly dependent on the position of the personalized lens design in the design space. This was consistent with the structure of the design space. (2) 82% of the subjects chose personalized lenses as their favorite. Most subjects reported higher wearing comfort and tolerability with personalized lenses than with conventional lenses. The designs of the tested personalized lenses were perceived by the subjects as intended. This is a prerequisite to the successful customization of PALs to individual wearing preferences. Possible reasons for the preference of the tested personalized lenses are the optimization with respect to individual wearing conditions and the personalization.

Complete super-sample lensing covariance in the response approach

NASA Astrophysics Data System (ADS)

Barreira, Alexandre; Krause, Elisabeth; Schmidt, Fabian

2018-06-01

We derive the complete super-sample covariance (SSC) of the matter and weak lensing convergence power spectra using the power spectrum response formalism to accurately describe the coupling of super- to sub-survey modes. The SSC term is completely characterized by the survey window function, the nonlinear matter power spectrum and the full first-order nonlinear power spectrum response function, which describes the response to super-survey density and tidal field perturbations. Generalized separate universe simulations can efficiently measure these responses in the nonlinear regime of structure formation, which is necessary for lensing applications. We derive the lensing SSC formulae for two cases: one under the Limber and flat-sky approximations, and a more general one that goes beyond the Limber approximation in the super-survey mode and is valid for curved sky applications. Quantitatively, we find that for sky fractions fsky ≈ 0.3 and a single source redshift at zS=1, the use of the flat-sky and Limber approximation underestimates the total SSC contribution by ≈ 10%. The contribution from super-survey tidal fields to the lensing SSC, which has not been included in cosmological analyses so far, is shown to represent about 5% of the total lensing covariance on multipoles l1,l2 gtrsim 300. The SSC is the dominant off-diagonal contribution to the total lensing covariance, making it appropriate to include these tidal terms and beyond flat-sky/Limber corrections in cosmic shear analyses.

Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release

PubMed Central

2015-01-01

Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation. PMID:24506583

Photometric redshift requirements for lens galaxies in galaxy-galaxy lensing analyses

NASA Astrophysics Data System (ADS)

Nakajima, R.; Mandelbaum, R.; Seljak, U.; Cohn, J. D.; Reyes, R.; Cool, R.

2012-03-01

Weak gravitational lensing is a valuable probe of galaxy formation and cosmology. Here we quantify the effects of using photometric redshifts (photo-z) in galaxy-galaxy lensing, for both sources and lenses, both for the immediate goal of using galaxies with photo-z as lenses in the Sloan Digital Sky Survey (SDSS) and as a demonstration of methodology for large, upcoming weak lensing surveys that will by necessity be dominated by lens samples with photo-z. We calculate the bias in the lensing mass calibration as well as consequences for absolute magnitude (i.e. k-corrections) and stellar mass estimates for a large sample of SDSS Data Release 8 (DR8) galaxies. The redshifts are obtained with the template-based photo-z code ZEBRA on the SDSS DR8 ugriz photometry. We assemble and characterize the calibration samples (˜9000 spectroscopic redshifts from four surveys) to obtain photometric redshift errors and lensing biases corresponding to our full SDSS DR8 lens and source catalogues. Our tests of the calibration sample also highlight the impact of observing conditions in the imaging survey when the spectroscopic calibration covers a small fraction of its footprint; atypical imaging conditions in calibration fields can lead to incorrect conclusions regarding the photo-z of the full survey. For the SDSS DR8 catalogue, we find σΔz/(1+z)= 0.096 and 0.113 for the lens and source catalogues, with flux limits of r= 21 and 21.8, respectively. The photo-z bias and scatter is a function of photo-z and template types, which we exploit to apply photo-z quality cuts. By using photo-z rather than spectroscopy for lenses, dim blue galaxies and L* galaxies up to z˜ 0.4 can be used as lenses, thus expanding into unexplored areas of parameter space. We also explore the systematic uncertainty in the lensing signal calibration when using source photo-z, and both lens and source photo-z; given the size of existing training samples, we can constrain the lensing signal calibration (and

Development of Ciprofloxacin-loaded contact lenses using fluorous chemistry

PubMed Central

Zhu, Zhiling; Li, Siheng; McDermott, Alison M.

2017-01-01

In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity. PMID:28188995

Effect of phospholipid deposits on adhesion of bacteria to contact lenses.

PubMed

Babaei Omali, Negar; Proschogo, Nicholas; Zhu, Hua; Zhao, Zhenjun; Diec, Jennie; Borazjani, Roya; Willcox, Mark D P

2012-01-01

Protein and lipid deposits on contact lenses may contribute to clinical complications. This study examined the effect of phospholipids on the adhesion of bacteria to contact lenses. Worn balafilcon A (n = 11) and senofilcon A (n = 11) were collected after daily wear and phospholipids were extracted in chloroform:methanol. The amount of phospholipid was measured by electrospray ionization mass spectrometry. Unworn lenses soaked in phospholipids were exposed to Pseudomonas aeruginosa and Staphylococcus aureus. After 18 h incubation, the numbers of P. aeruginosa or S. aureus that adhered to the lenses were measured. Phospholipid was tested for possible effects on bacterial growth. A broad range of sphingomyelins (SM) and phosphatidylcholines (PC) were detected from both types of worn lenses. SM (16:0) (m/z 703) and PC (34:2) (m/z 758) were the major phospholipids detected in the lens extracts. Phospholipids did not alter the adhesion of any strain of P. aeruginosa or S. aureus (p > 0.05). Phospholipids (0.1 mg/mL) showed no effect on the growth of P. aeruginosa 6294 or S. aureus 031. Phospholipids adsorb/absorb to contact lenses during wear, however, the major types of phospholipids adsorbed to lenses do not alter bacterial adhesion or growth.

CLASH: Joint analysis of strong-lensing, weak-lensing shear, and magnification data for 20 galaxy clusters*

DOE PAGES

Umetsu, Keiichi; Zitrin, Adi; Gruen, Daniel; ...

2016-04-20

Here, we present a comprehensive analysis of strong-lensing, weak-lensing shear and magnification data for a sample of 16 X-ray-regular and 4 high-magnification galaxy clusters atmore » $$0.19\\lesssim z\\lesssim 0.69$$ selected from Cluster Lensing And Supernova survey with Hubble (CLASH). Our analysis combines constraints from 16-band Hubble Space Telescope observations and wide-field multi-color imaging taken primarily with Suprime-Cam on the Subaru Telescope, spanning a wide range of cluster radii (10''–16'). We reconstruct surface mass density profiles of individual clusters from a joint analysis of the full lensing constraints, and determine masses and concentrations for all of the clusters. We find the internal consistency of the ensemble mass calibration to be ≤5% ± 6% in the one-halo regime (200–2000 kpc h –1) compared to the CLASH weak-lensing-only measurements of Umetsu et al. For the X-ray-selected subsample of 16 clusters, we examine the concentration–mass (c–M) relation and its intrinsic scatter using a Bayesian regression approach. Our model yields a mean concentration of $$c{| }_{z=0.34}=3.95\\pm 0.35$$ at M200c sime 14 × 1014 M⊙ and an intrinsic scatter of $$\\sigma (\\mathrm{ln}{c}_{200{\\rm{c}}})=0.13\\pm 0.06$$, which is in excellent agreement with Λ cold dark matter predictions when the CLASH selection function based on X-ray morphological regularity and the projection effects are taken into account. We also derive an ensemble-averaged surface mass density profile for the X-ray-selected subsample by stacking their individual profiles. The stacked lensing signal is detected at 33σ significance over the entire radial range ≤4000 kpc h –1, accounting for the effects of intrinsic profile variations and uncorrelated large-scale structure along the line of sight. The stacked mass profile is well described by a family of density profiles predicted for cuspy dark-matter-dominated halos in gravitational equilibrium, namely, the

A New Concept of Coronagraph using Axicon Lenses

NASA Astrophysics Data System (ADS)

Choi, Jae Ho

2017-06-01

High-contrast direct imaging of faint objects nearby bright stellar is essential to investigate planetary systems. The goal of such effort is to find and characterize planets similar to Earth that is a challenging task due to it requires a high angular resolution and high dynamic range detections concurrently. A coronagraph that can be suppressed the bright stellar light or active galactic nuclei during the direct detection of astrophysical activities became one of the essential instruments to image exoplanets. In this presentation, a novel concept of a coronagraph using axicon-lenses is will be presented that is conjunction with a method of noninterferometric quantitative phase imaging for direct imaging of exoplanets. The essential scheme of the axicon-lenses coronagraph is the apodization carried out by excluding evaginated images of the planetary systems by a pair of axicon lens. The laboratory based coronagraph imaging is carried out with the axicon-lenses coronagraph setup which included the axicon lenses optics and phase contrast imaging unit. A simulated stellar and its companion are provided by illuminating light through small holes drilled on a thin metal plate. Those diffracted light at the edge of the holes bears a similarity to the light from the bright stellar. The images are evaginated about the optical axis by passing the first axicon lens. Then the evaginated beams of its external area have cut off by an iris which means the suppressed its central light of the bright stellar light preferentially. A symbolic calculation also is carried out to verify the scheme of the the axicon-lenses coronagraph using the symbolic computation program. The simulation results are shown that the the axicon-lenses coronagraph has feature of ability to achieve the IWA smaller than l/D. The laboratory based coronagraph imaging and simulation results support its potentials in direct imaging for finding exo-planet and various astrophysical activities.

Scleral Lenses in the Management of Corneal Irregularity and Ocular Surface Disease.

PubMed

Shorter, Ellen; Harthan, Jennifer; Nau, Cherie B; Nau, Amy; Barr, Joseph T; Hodge, David O; Schornack, Muriel M

2017-09-29

To describe current practice patterns regarding the use of scleral lens therapy in the management of corneal irregularity and ocular surface disease among eye care providers who fit scleral lenses. The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group conducted an electronic survey of eye care providers from January 15 to March 31, 2015. Respondents ranked management options for corneal irregularity in the order in which they would generally consider their use. Respondents also ranked options for the management of ocular surface disease in the order in which they would use each of the treatments. Results for each option were analyzed as percentage first-place ranking; percentage first-, second-, or third-place ranking; and mean rank score. Survey responses were obtained from 723 providers who had fit 5 or more scleral lenses. Of these respondents, 629 ranked options for management of corneal irregularity and 612 ranked options for management of ocular surface disease. Corneal rigid gas-permeable lenses were the first option for management of corneal irregularity for 44% of respondents, and scleral lenses were the first option for 34% of respondents. Lubricant drops were the first therapeutic recommendation for ocular surface disease for 84% of respondents, and scleral lenses were ranked first by 6% of respondents. Scleral lenses rank second only to corneal rigid gas-permeable lenses for management of corneal irregularity. Scleral lenses are generally considered after other medical intervention and before surgery for the management of ocular surface disease.

Dimensional stability of lathe cut C.A.B. lenses.

PubMed

Pearson, R M

1978-08-01

Measurements of the back central optical radius in the course of 336 hours of hydration of lathe cut corneal lenses disclosed changes in curvature which were more rapid and of greater magnitude than those previously reported for poly (methyl methacrylate) lenses.

Intraocular lenses in age-related macular degeneration.

PubMed

Grzybowski, Andrzej; Wasinska-Borowiec, Weronika; Alio, Jorge L; Amat-Peral, Pedro; Tabernero, Juan

2017-09-01

The aim of this work is to review the lenses, assessing their advantages and disadvantages. We describe a total of seven types of intraocular lenses (IOLs) recommended for age-related macular degeneration (AMD). We used the PubMed web platform to search for implantable devices in various stages of AMD. We searched for both prospective and retrospective studies and also case reports. Clinical results in AMD patients have been described for a total of seven types of IOLs recommended for AMD: an implantable miniature telescope (IMT), IOL-VIP System, Lipshitz macular implant (LMI), sulcus-implanted Lipshitz macular implant, LMI-SI, Fresnel Prism Intraocular Lens, iolAMD and Scharioth Macula Lens. We conclude that to objectively ascertain the effectiveness and safety of these lenses, further independent clinical studies with longer follow-up data are necessary prior to the general use of these optical devices.

High Quality Liquid Crystal Tunable Lenses and Optimization with Floating Electrodes

ERIC Educational Resources Information Center

Li, Liwei

2013-01-01

In addition to the display application, Liquid Crystals (LC) can be very useful in other applications such as beam steering, tunable lenses, etc. Electro-optical LC tunable lenses have been considered as an alternative to conventional glass lenses because of their ability to change their focal length with the application of a control voltage, as…

Ultrathin zoom lens system based on liquid lenses

NASA Astrophysics Data System (ADS)

Li, Lei; Liu, Chao; Wang, Qiong-Hua

2015-07-01

In this paper, we propose an ultrathin zoom lens system based on liquid lenses. The proposed system consists of an annular folded lens and three electrowetting liquid lenses. The annular folded lens has several concentric surfaces. The annular folded lens is used to get the main power and correct aberrations. The three liquid lenses are used to change the focal length and correct aberration. An analysis of the proposed system is presented along with the design, fabrication, and testing of a prototype. All the elements in the proposed system are very thin, so the system is an ultrathin zoom lens system, which has potential application as lightweight, thin, high-quality imagers for aerospace, consumer, and military applications.

Impact of spurious shear on cosmological parameter estimates from weak lensing observables

DOE PAGES

Petri, Andrea; May, Morgan; Haiman, Zoltán; ...

2014-12-30

We research, residual errors in shear measurements, after corrections for instrument systematics and atmospheric effects, can impact cosmological parameters derived from weak lensing observations. Here we combine convergence maps from our suite of ray-tracing simulations with random realizations of spurious shear. This allows us to quantify the errors and biases of the triplet (Ω m,w,σ 8) derived from the power spectrum (PS), as well as from three different sets of non-Gaussian statistics of the lensing convergence field: Minkowski functionals (MFs), low-order moments (LMs), and peak counts (PKs). Our main results are as follows: (i) We find an order of magnitudemore » smaller biases from the PS than in previous work. (ii) The PS and LM yield biases much smaller than the morphological statistics (MF, PK). (iii) For strictly Gaussian spurious shear with integrated amplitude as low as its current estimate of σ sys 2 ≈ 10 -7, biases from the PS and LM would be unimportant even for a survey with the statistical power of Large Synoptic Survey Telescope. However, we find that for surveys larger than ≈ 100 deg 2, non-Gaussianity in the noise (not included in our analysis) will likely be important and must be quantified to assess the biases. (iv) The morphological statistics (MF, PK) introduce important biases even for Gaussian noise, which must be corrected in large surveys. The biases are in different directions in (Ωm,w,σ8) parameter space, allowing self-calibration by combining multiple statistics. Our results warrant follow-up studies with more extensive lensing simulations and more accurate spurious shear estimates.« less

From Triple to Quadruple Aim: Care of the Patient Requires Care of the Provider

PubMed Central

Bodenheimer, Thomas; Sinsky, Christine

2014-01-01

The Triple Aim—enhancing patient experience, improving population health, and reducing costs—is widely accepted as a compass to optimize health system performance. Yet physicians and other members of the health care workforce report widespread burnout and dissatisfaction. Burnout is associated with lower patient satisfaction, reduced health outcomes, and it may increase costs. Burnout thus imperils the Triple Aim. This article recommends that the Triple Aim be expanded to a Quadruple Aim, adding the goal of improving the work life of health care providers, including clinicians and staff. PMID:25384822

The influence of Coulomb correlations on nonequilibrium quantum transport in quadruple quantum-dot structure

NASA Astrophysics Data System (ADS)

Kagan, M. Yu.; Aksenov, S. V.

2018-04-01

The description of quantum transport in a quadruple quantum-dot structure (QQD) is proposed taking into account the Coulomb correlations and nonzero bias voltages. To achieve this goal the combination of nonequilibrium Green's functions and equation-of-motion technique is used. It is shown that the anisotropy of kinetic processes in the QQD leads to negative differential conductance (NDC). The reason of the effect is an interplay of the Fano resonances which are induced by the interdot Coulomb correlations. Different ways to increase the peak-to-valley ratio related to the observed NDC are discussed.

14 day sequential therapy versus 10 day bismuth quadruple therapy containing high-dose esomeprazole in the first-line and second-line treatment of Helicobacter pylori: a multicentre, non-inferiority, randomized trial.

PubMed

Liou, Jyh-Ming; Chen, Chieh-Chang; Fang, Yu-Jen; Chen, Po-Yueh; Chang, Chi-Yang; Chou, Chu-Kuang; Chen, Mei-Jyh; Tseng, Cheng-Hao; Lee, Ji-Yuh; Yang, Tsung-Hua; Chiu, Min-Chin; Yu, Jian-Jyun; Kuo, Chia-Chi; Luo, Jiing-Chyuan; Hsu, Wen-Feng; Hu, Wen-Hao; Tsai, Min-Horn; Lin, Jaw-Town; Shun, Chia-Tung; Twu, Gary; Lee, Yi-Chia; Bair, Ming-Jong; Wu, Ming-Shiang

2018-05-29

Whether extending the treatment length and the use of high-dose esomeprazole may optimize the efficacy of Helicobacter pylori eradication remains unknown. To compare the efficacy and tolerability of optimized 14 day sequential therapy and 10 day bismuth quadruple therapy containing high-dose esomeprazole in first-line therapy. We recruited 620 adult patients (≥20 years of age) with H. pylori infection naive to treatment in this multicentre, open-label, randomized trial. Patients were randomly assigned to receive 14 day sequential therapy or 10 day bismuth quadruple therapy, both containing esomeprazole 40 mg twice daily. Those who failed after 14 day sequential therapy received rescue therapy with 10 day bismuth quadruple therapy and vice versa. Our primary outcome was the eradication rate in the first-line therapy. Antibiotic susceptibility was determined. ClinicalTrials.gov: NCT03156855. The eradication rates of 14 day sequential therapy and 10 day bismuth quadruple therapy were 91.3% (283 of 310, 95% CI 87.4%-94.1%) and 91.6% (284 of 310, 95% CI 87.8%-94.3%) in the ITT analysis, respectively (difference -0.3%, 95% CI -4.7% to 4.4%, P = 0.886). However, the frequencies of adverse effects were significantly higher in patients treated with 10 day bismuth quadruple therapy than those treated with 14 day sequential therapy (74.4% versus 36.7% P < 0.0001). The eradication rate of 14 day sequential therapy in strains with and without 23S ribosomal RNA mutation was 80% (24 of 30) and 99% (193 of 195), respectively (P < 0.0001). Optimized 14 day sequential therapy was non-inferior to, but better tolerated than 10 day bismuth quadruple therapy and both may be used in first-line treatment in populations with low to intermediate clarithromycin resistance.

Protein deposition and its effect on bacterial adhesion to contact lenses.

PubMed

Omali, Negar Babaei; Zhu, Hua; Zhao, Zhenjun; Willcox, Mark D P

2013-06-01

Bacterial adhesion to contact lenses is believed to be the initial step for the development of several adverse reactions that occur during lens wear such as microbial keratitis. This study examined the effect of combinations of proteins on the adhesion of bacteria to contact lenses. Unworn balafilcon A and senofilcon A lenses were soaked in commercially available pure protein mixtures to achieve the same amount of various proteins as found ex vivo. These lenses were then exposed to Pseudomonas aeruginosa and Staphylococcus aureus. Following incubation, the numbers of P. aeruginosa or S. aureus that adhered to the lenses were measured. The possible effect of proteins on bacterial growth was investigated by incubating bacteria in medium containing protein. Although there was a significant (p < 0.003) increase in the total or viable counts of one strain of S. aureus (031) on balafilcon A lenses soaked in the lysozyme/lactoferrin combination, the protein adhered to lenses did not alter the adhesion of any other strains of P. aeruginosa or S. aureus (p > 0.05). Growth of S. aureus 031 (p < 0.0001) but not of P. aeruginosa 6294 was stimulated by addition of lysozyme/lactoferrin combination (2.8/0.5 mg/mL). Addition of lipocalin did not affect the growth of any strains tested (p > 0.05). Adsorption of amounts of lysozyme and lactoferrin or lipocalin equivalent to those extracted from worn contact lenses did not affect the adhesion of most strains of S. aureus or P. aeruginosa to lens surfaces.

Fresnel's Lighthouse Lenses

ERIC Educational Resources Information Center

Greenslade, Thomas B., Jr.

2007-01-01

One of the rewards of walking up the scores of steps winding around the inside of the shaft of a lighthouse is turning inward and examining the glass optical system. This arrangement of prisms, lenses, and reflectors is used to project the light from a relatively small source in a beam that can be seen far at sea.

Salicylate inhibition of acanthamoebal attachment to contact lenses.

PubMed

Beattie, Tara K; Tomlinson, Alan; Seal, David V; McFadyen, Angus K

2011-12-01

Sodium salicylate has shown potential as a component of contact lens care solutions designed to reduce Acanthamoebal attachment to contact lenses. This study determined the minimum effective concentration required to significantly reduce amoebal attachment. Different concentrations of sodium salicylate (10, 15, and 20 mM) were applied during exposure of unworn or bacterial biofilm-coated hydrogel contact lenses to Acanthamoeba castellanii trophozoites. Salicylate was applied at stage 1 intervention during biofilm formation on lenses, at stage 2 intervention during amoebal exposure, or at both stages. A significant reduction in amoebal attachment was achieved when 10 mM salicylate was included during stage 1 alone; however, 15 mM was required for stage 2 intervention to significantly reduce attachment to clean or biofilm-coated lenses. For stages 1 and 2 combined intervention, 10 mM sodium salicylate produced a significant reduction in amoebal attachment. In situ, within a contact lens case, biofilm formation and amoebal attachment would occur concurrently; therefore, stages 1 and 2 intervention would be closest to the real-life situation, thus indicating that 10 mM of salicylate would be an effective minimum concentration for reducing amoebal attachment to hydrogel contact lenses. Inclusion of components in contact lens care solution, such as sodium salicylate, which reduce Acanthamoebal attachment, has the potential to enhance effectiveness, particularly where amoebicidal efficacy may be limited, thus reducing the risk of contact lens-associated Acanthamoebal infection.

Lensing is low: cosmology, galaxy formation or new physics?

NASA Astrophysics Data System (ADS)

Leauthaud, Alexie; Saito, Shun; Hilbert, Stefan; Barreira, Alexandre; More, Surhud; White, Martin; Alam, Shadab; Behroozi, Peter; Bundy, Kevin; Coupon, Jean; Erben, Thomas; Heymans, Catherine; Hildebrandt, Hendrik; Mandelbaum, Rachel; Miller, Lance; Moraes, Bruno; Pereira, Maria E. S.; Rodríguez-Torres, Sergio A.; Schmidt, Fabian; Shan, Huan-Yuan; Viel, Matteo; Villaescusa-Navarro, Francisco

2017-05-01

We present high signal-to-noise galaxy-galaxy lensing measurements of the Baryon Oscillation Spectroscopic Survey constant mass (CMASS) sample using 250 deg2 of weak-lensing data from Canada-France-Hawaii Telescope Lensing Survey and Canada-France-Hawaii Telescope Stripe 82 Survey. We compare this signal with predictions from mock catalogues trained to match observables including the stellar mass function and the projected and two-dimensional clustering of CMASS. We show that the clustering of CMASS, together with standard models of the galaxy-halo connection, robustly predicts a lensing signal that is 20-40 per cent larger than observed. Detailed tests show that our results are robust to a variety of systematic effects. Lowering the value of S_8=σ _8 \\sqrt{Ω _m/0.3} compared to Planck Collaboration XIII reconciles the lensing with clustering. However, given the scale of our measurement (r < 10 h-1 Mpc), other effects may also be at play and need to be taken into consideration. We explore the impact of baryon physics, assembly bias, massive neutrinos and modifications to general relativity on ΔΣ and show that several of these effects may be non-negligible given the precision of our measurement. Disentangling cosmological effects from the details of the galaxy-halo connection, the effect of baryons, and massive neutrinos, is the next challenge facing joint lensing and clustering analyses. This is especially true in the context of large galaxy samples from Baryon Acoustic Oscillation surveys with precise measurements but complex selection functions.

[Laboratory study of the cytotoxicity of colored soft contact lenses].

PubMed

Almesmary, A A

1999-01-01

In the clinical practice we have met with the fact that some patients did not tolerate soft coloured contact lenses even when they used them for a short time. To find whether the cause is the composition of these lenses, mainly the adding of stain, he used the laboratory test to determine cytotoxicity, the test of dynamic observation of cytotoxicity where the cells cultured in vitro are the experimental object. On the basis of the results of this test commonly used for the determination of the cytotoxicity of implantation materials, he thinks that the cause of intolerance of coloured lenses is not their toxicity but other phenomena. An individual hypersensitivity or insufficient care of lenses (the influence of disinfectants) can be among these causes.

Electron lenses for head-on beam-beam compensation in RHIC

DOE PAGES

Gu, X.; Fischer, W.; Altinbas, Z.; ...

2017-02-17

Two electron lenses (e-lenses) have been in operation during 2015 RHIC physics run as part of a head-on beam-beam compensation scheme. While the RHIC lattice was chosen to reduce the beam-beam induced resonance driving terms, the electron lenses reduced the beam-beam induced tune spread. This has been demonstrated for the first time. The beam-beam compensation scheme allows for higher beam-beam parameters and therefore higher intensities and luminosity. In this paper, we detailed the design considerations and verification of the electron beam parameters of the RHIC e-lenses. Lastly, longitudinal and transverse alignments with ion beams and the transverse beam transfer functionmore » (BTF) measurement with head-on electron-proton beam are presented.« less

Surface geometry and optical aberrations of ex-vivo crystalline lenses

NASA Astrophysics Data System (ADS)

Bueno, Juan M.; Schwarz, Christina; Acosta, Eva; Artal, Pablo

2010-02-01

The shape of the surfaces of ex-vivo human crystalline lenses was measured using a shadow photography technique. From these data, the back-focal distance and the contribution of each surface to the main optical aberrations of the lenses were estimated. The aberrations of the lenses were measured separately with two complementary techniques: a Hartmann-Shack wavefront sensor and a point-diffraction interferometer. A laser scanning set-up was also used to measure the actual back-focal length as well as the phase aberration in one meridian section of the lenses. Measured and predicted back-focal length agreed well within the experimental errors. The lens aberrations computed with a ray-tracing approach from the measured surfaces and geometrical data only reproduce quantitatively the measured aberrations.

Electron lenses for head-on beam-beam compensation in RHIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gu, X.; Fischer, W.; Altinbas, Z.

Two electron lenses (e-lenses) have been in operation during 2015 RHIC physics run as part of a head-on beam-beam compensation scheme. While the RHIC lattice was chosen to reduce the beam-beam induced resonance driving terms, the electron lenses reduced the beam-beam induced tune spread. This has been demonstrated for the first time. The beam-beam compensation scheme allows for higher beam-beam parameters and therefore higher intensities and luminosity. In this paper, we detailed the design considerations and verification of the electron beam parameters of the RHIC e-lenses. Lastly, longitudinal and transverse alignments with ion beams and the transverse beam transfer functionmore » (BTF) measurement with head-on electron-proton beam are presented.« less

Flat liquid crystal diffractive lenses with variable focus and magnification

NASA Astrophysics Data System (ADS)

Valley, Pouria

Non-mechanical variable lenses are important for creating compact imaging devices. Various methods employing dielectrically actuated lenses, membrane lenses, and liquid crystal lenses were previously proposed [1-4]. In This dissertation the design, fabrication, and characterization of innovative flat tunable-focus liquid crystal diffractive lenses (LCDL) are presented. LCDL employ binary Fresnel zone electrodes fabricated on Indium-Tin-Oxide using conventional micro-photolithography. The light phase can be adjusted by varying the effective refractive index of a nematic liquid crystal sandwiched between the electrodes and a reference substrate. Using a proper voltage distribution across various electrodes the focal length can be changed between several discrete values. Electrodes are shunted such that the correct phase retardation step sequence is achieved. If the number of 2pi zone boundaries is increased by a factor of m the focal length is changed from f to f/m based on the digitized Fresnel zone equation: f = rm2/2mlambda, where r m is mth zone radius, and lambda is the wavelength. The chromatic aberration of the diffractive lens is addressed and corrected by adding a variable fluidic lens. These LCDL operate at very low voltage levels (+/-2.5V ac input), exhibit fast switching times (20-150 ms), can have large apertures (>10 mm), and small form factor, and are robust and insensitive to vibrations, gravity, and capillary effects that limit membrane and dielectrically actuated lenses. Several tests were performed on the LCDL including diffraction efficiency measurement, switching dynamics, and hybrid imaging with a refractive lens. Negative focal lengths are achieved by adjusting the voltages across electrodes. Using these lenses in combination, magnification can be changed and zoom lenses can be formed. These characteristics make LCDL a good candidate for a variety of applications including auto-focus and zoom lenses in compact imaging devices such as camera

[What is the role of contact lenses within the scope of electronystagmography?].

PubMed

Schmäl, F; Stoll, W

1997-10-01

During electronystagmography it is necessary to correct detective vision for calibration, smooth pursuit, and saccadic eye movements. Therefore more and more people use contact lenses instead of normal glasses. Given the lack of detailed information about this phenomenon, in the current literature we decided to investigate the influence of soft contact lenses on electronystagmography. The aim of this study was to find out differences in the results of electronystagmography between using glasses or contact lenses. Our investigation involved 20 vestibular healthy human subjects with myopia. In the first part of the examination they used their contact lenses and in the second part they were wearing normal glasses. After measuring the calibration potential we wanted to see if contact lenses would increase the rate of artifacts in the electronystagmogram. Then we attempted to determine whether contact lenses would an influence on the registration of the optokinetic nystagmus. Induced saccadic eye movements were recorded and analysed. Contact lenses had a negative influence neither on the calibration potential nor on the rate of artifacts. The latency of the saccadic eye movements also showed no differences between both parts of this investigation. Only the velocity of the saccades and the gain value during the optokinetic test were reduced when glasses were used. Contact lenses may stimulate the secretory function of the lacrimal gland and thus decrease friction forces. It is also possible that the reduced image size produced or the reduction-effect of minus by glasses in near sighted persons negatively influences eyeball velocity. In summary, our study demonstrates that contact lenses do not have a negative influence on electronystagmography. Therefore electronystagmographic studies of patients with contact lenses are permissible for purposes of documenting a medical opinion.

Lensed Type Ia supernovae as probes of cluster mass models

Science.gov Websites

SAO/NASA ADS Astronomy Abstract Service Title: Lensed Type Ia supernovae as probes of cluster mass Origin: OUP Astronomy Keywords: gravitational lensing: strong, supernovae: general, galaxies: clusters

Interpreting the Strongly Lensed Supernova iPTF16geu: Time Delay Predictions, Microlensing, and Lensing Rates

DOE Office of Scientific and Technical Information (OSTI.GOV)

More, Anupreeta; Oguri, Masamune; More, Surhud

2017-02-01

We present predictions for time delays between multiple images of the gravitationally lensed supernova, iPTF16geu, which was recently discovered from the intermediate Palomar Transient Factory (iPTF). As the supernova is of Type Ia where the intrinsic luminosity is usually well known, accurately measured time delays of the multiple images could provide tight constraints on the Hubble constant. According to our lens mass models constrained by the Hubble Space Telescope F814W image, we expect the maximum relative time delay to be less than a day, which is consistent with the maximum of 100 hr reported by Goobar et al. but placesmore » a stringent upper limit. Furthermore, the fluxes of most of the supernova images depart from expected values suggesting that they are affected by microlensing. The microlensing timescales are small enough that they may pose significant problems to measure the time delays reliably. Our lensing rate calculation indicates that the occurrence of a lensed SN in iPTF is likely. However, the observed total magnification of iPTF16geu is larger than expected, given its redshift. This may be a further indication of ongoing microlensing in this system.« less

Low Cost DIY Lenses kit For High School Teaching

NASA Astrophysics Data System (ADS)

Thepnurat, Meechai; Saphet, Parinya; Tong-on, Anusorn

2017-09-01

A set of lenses was fabricated from a low cost materials in a DIY (Do it yourself) process. The purpose was to demonstrate to teachers and students in high schools how to construct lenses by themselves with the local available materials. The lenses could be applied in teaching Physics, about the nature of a lens such as focal length and light rays passing through lenses in either direction, employing a set of simple laser pointers. This instrumental kit was made from a transparent 2 mm thick of acrylic Perspex. It was cut into rectangular pieces with dimensions of 2x15 cm2 and bent into curved shape by a hot air blower on a cylindrical wooden rod with curvature radii of about 3-4.5 cm. Then a pair of these Perspex were formed into a hollow thick lenses with a base supporting platform, so that any appropriate liquids could be filled in. The focal length of the lens was measured from laser beam drawing on a paper. The refractive index, n (n) of a filling liquid could be calculated from the measured focal length (f). The kit was low cost and DIY but was greatly applicable for optics teaching in high school laboratory.

[Infectious keratitis and cosmetic lenses: a five-case retrospective study].

PubMed

Guyomarch, J; van Nuoï, D N'guyen; Beral, L; Donnio, A; Desbois, N; Olive, C; Theodose, R; Merle, H

2010-04-01

To determine the characteristics of infectious keratitis related to plano cosmetic lenses. Retrospective case study of a series of infectious keratitis among plano cosmetic lenses wearers. The main parameters were demographic data, medical history, risk factors for infectious complications and keratitis severity criteria, microbiological results, clinical course, and final visual acuity. Five patients were included, all females, ranging from 15 to 50 years of age. Four were emmetropic. One patient had undergone refractive photokeratectomy a few months before. All had risk factors for infectious complications. The fundamental causes of infections were diverse: bacterial abscesses, keratomycosis, and amoebic keratitis. All presented severity criteria. In two cases, the keratitis led to severe consequences with legal blindness requiring penetrating keratoplasty in one case. Infectious keratitis in plano cosmetic lenses wearers is not rare and may have dramatic consequences. Sales are specifically regulated and the lenses are considered cosmetic products, not medical devices. The sales regulations for plano cosmetic lenses should be updated, as several countries have already done after encountering many serious incidents. Copyright 2010 Elsevier Masson SAS. All rights reserved.

Discovery of the Lensed Quasar System DES J0408-5354

DOE PAGES

Lin, H.; Buckley-Geer, E.; Agnello, A.; ...

2017-03-27

We report the discovery and spectroscopic confirmation of the quad-like lensed quasar system DES J0408-5354 found in the Dark Energy Survey (DES) Year 1 (Y1) data. This system was discovered during a search for DES Y1 strong lensing systems using a method that identified candidates as red galaxies with multiple blue neighbors. DES J0408-5354 consists of a central red galaxy surrounded by three bright (more » $$i\\lt 20$$) blue objects and a fourth red object. Subsequent spectroscopic observations using the Gemini South telescope confirmed that the three blue objects are indeed the lensed images of a quasar with redshift z = 2.375, and that the central red object is an early-type lensing galaxy with redshift z = 0.597. DES J0408-5354 is the first quad lensed quasar system to be found in DES and begins to demonstrate the potential of DES to discover and dramatically increase the sample size of these very rare objects.« less

Cluster-lensing: A Python Package for Galaxy Clusters and Miscentering

NASA Astrophysics Data System (ADS)

Ford, Jes; VanderPlas, Jake

2016-12-01

We describe a new open source package for calculating properties of galaxy clusters, including Navarro, Frenk, and White halo profiles with and without the effects of cluster miscentering. This pure-Python package, cluster-lensing, provides well-documented and easy-to-use classes and functions for calculating cluster scaling relations, including mass-richness and mass-concentration relations from the literature, as well as the surface mass density {{Σ }}(R) and differential surface mass density {{Δ }}{{Σ }}(R) profiles, probed by weak lensing magnification and shear. Galaxy cluster miscentering is especially a concern for stacked weak lensing shear studies of galaxy clusters, where offsets between the assumed and the true underlying matter distribution can lead to a significant bias in the mass estimates if not accounted for. This software has been developed and released in a public GitHub repository, and is licensed under the permissive MIT license. The cluster-lensing package is archived on Zenodo. Full documentation, source code, and installation instructions are available at http://jesford.github.io/cluster-lensing/.

Discovery of the Lensed Quasar System DES J0408-5354

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, H.; Buckley-Geer, E.; Agnello, A.

We report the discovery and spectroscopic confirmation of the quad-like lensed quasar system DES J0408-5354 found in the Dark Energy Survey (DES) Year 1 (Y1) data. This system was discovered during a search for DES Y1 strong lensing systems using a method that identified candidates as red galaxies with multiple blue neighbors. DES J0408-5354 consists of a central red galaxy surrounded by three bright (more » $$i\\lt 20$$) blue objects and a fourth red object. Subsequent spectroscopic observations using the Gemini South telescope confirmed that the three blue objects are indeed the lensed images of a quasar with redshift z = 2.375, and that the central red object is an early-type lensing galaxy with redshift z = 0.597. DES J0408-5354 is the first quad lensed quasar system to be found in DES and begins to demonstrate the potential of DES to discover and dramatically increase the sample size of these very rare objects.« less

Microbiologic study of soft contact lenses after laser subepithelial keratectomy for myopia.

PubMed

Hondur, Ahmet; Bilgihan, Kamil; Cirak, Meltem Yalinay; Dogan, Ozgur; Erdinc, Alper; Hasanreisoglu, Berati

2008-01-01

To evaluate the extent and agents of bacterial contamination of bandage disposable soft contact lenses after laser subepithelial keratectomy (LASEK) and to correlate the findings with clinical data. Disposable soft contact lenses were collected from 52 eyes of 26 consecutive patients treated with LASEK for myopia. The patients were treated with a fixed combination of tobramycin and diclofenac until epithelial closure. The lenses were removed on the fourth or fifth postoperative day with sterile forceps and immediately placed in sterile tubes containing culture media brain-heart infusion broth. The lenses were evaluated for microbial colonization. Of the 52 contact lenses analyzed, six (11.5%) had positive cultures. However, no clinical finding of infection was noted. Isolated microorganisms were coagulase-negative staphylococci (two lenses), Stenotrophomonas maltophilia (two lenses), Acinetobacter species (one lens), and Aeromonas hydrophila (one lens). Except for one case, the microorganisms were sensitive to the administered antibiotic. The risk of infectious keratitis after LASEK seems to be low. Except for staphylococci, the isolated microorganisms have not been previously reported to colonize the ocular surface or cause keratitis after refractive surgery. These findings may suggest a changing trend of potentially infectious agents after surface ablation.

Evaluation of antioxidants and argpyrimidine in normal and cataractous lenses in north Indian population

PubMed Central

Mynampati, Bharani K; Ghosh, Sujata; Muthukumarappa, Thungapathra; Ram, Jagat

2017-01-01

AIM To assess the level of glutathione, thioltransferase, and argpyrimidine in nuclear and cortical cataractous lenses as well as in the clear lenses in the north Indian population. METHODS Human cataractous lenses were collected from the patients who underwent extracapsular cataract extraction surgery; clear lenses were collected from the freshly donated eye bank eyes. Antioxidant molecules such as glutathione and thioltransferase enzyme activity were measured; simultaneously in these lenses a blue fluorophore argpyrimidine, an advanced glycation end (AGE) product level was assessed using high performance liquid chromatography (HPLC). RESULTS The protein concentration was found to be present at higher levels in the control lenses compared to cataract lenses. A significant decrease in the glutathione level was observed in the nuclear cataractous lenses compared to cortical cataractous (P=0.004) and clear lenses (P≤0.005), but no significant change in the level of antioxidant enzyme thioltransferase was observed. Further, argpyrimidine a blue fluorophore (AGE) was found to be significantly higher in the nuclear cataract (P=0.013) compared to cortical cataract lenses. CONCLUSION Antioxidants such as glutathione significantly decrease in age-related nuclear and cortical cataract and an AGE, argpyrimidine are present at significantly higher levels in nuclear cataract. PMID:28730112

Gravitational lensing in a cold dark matter universe

NASA Technical Reports Server (NTRS)

Narayan, Ramesh; White, Simon D. M.

1988-01-01

Gravitational lensing due to mass condensations in a biased cold dark matter (CDM) universe is investigated using the Press-Schechter (1974) theory with density fluctuation amplitudes taken from previous N-body work. Under the critical assumption that CDM haloes have small core radii, a distribution of image angular separations for high-z lensed quasars with a peak at about 1 arcsec and a half-width of a factor of about 10. Allowing for selection effects at small angular separations, this is in good agreement with the observed separations. The estimated frequency of lensing is somewhat lower than that observed, but the discrepancy can be removed by invoking amplification bias and by making a small upward adjustment to the density fluctuation amplitudes assumed in the CDM model.

Using cross correlations to calibrate lensing source redshift distributions: Improving cosmological constraints from upcoming weak lensing surveys

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Putter, Roland; Doré, Olivier; Das, Sudeep

2014-01-10

Cross correlations between the galaxy number density in a lensing source sample and that in an overlapping spectroscopic sample can in principle be used to calibrate the lensing source redshift distribution. In this paper, we study in detail to what extent this cross-correlation method can mitigate the loss of cosmological information in upcoming weak lensing surveys (combined with a cosmic microwave background prior) due to lack of knowledge of the source distribution. We consider a scenario where photometric redshifts are available and find that, unless the photometric redshift distribution p(z {sub ph}|z) is calibrated very accurately a priori (bias andmore » scatter known to ∼0.002 for, e.g., EUCLID), the additional constraint on p(z {sub ph}|z) from the cross-correlation technique to a large extent restores the cosmological information originally lost due to the uncertainty in dn/dz(z). Considering only the gain in photo-z accuracy and not the additional cosmological information, enhancements of the dark energy figure of merit of up to a factor of four (40) can be achieved for a SuMIRe-like (EUCLID-like) combination of lensing and redshift surveys, where SuMIRe stands for Subaru Measurement of Images and Redshifts). However, the success of the method is strongly sensitive to our knowledge of the galaxy bias evolution in the source sample and we find that a percent level bias prior is needed to optimize the gains from the cross-correlation method (i.e., to approach the cosmology constraints attainable if the bias was known exactly).« less

Simulations for 21 cm radiation lensing at EoR redshifts

NASA Astrophysics Data System (ADS)

Romeo, Alessandro; Metcalf, Robert Benton; Pourtsidou, Alkistis

2018-02-01

We introduce simulations aimed at assessing how well weak gravitational lensing of 21cm radiation from the Epoch of Reionization (z ˜ 8) can be measured by a Square Kilometre Array (SKA)-like radio telescope. A simulation pipeline has been implemented to study the performance of lensing reconstruction techniques. We show how well the lensing signal can be reconstructed using the 3D quadratic lensing estimator in Fourier space assuming different survey strategies. The numerical code introduced in this work is capable of dealing with issues that cannot be treated analytically such as the discreteness of visibility measurements and the inclusion of a realistic model for the antennas distribution. This paves the way for future numerical studies implementing more realistic re-ionization models, foreground subtraction schemes, and testing the performance of lensing estimators that take into account the non-Gaussian distribution of HI after re-ionization. If multiple frequency channels covering z ˜ 7-11.6 are combined, Phase 1 of SKA-Low should be able to obtain good quality images of the lensing potential with a total resolution of ˜1.6 arcmin. The SKA-Low Phase 2 should be capable of providing images with high fidelity even using data from z ˜ 7.7 to 8.3. We perform tests aimed at evaluating the numerical implementation of the mapping reconstruction. We also discuss the possibility of measuring an accurate lensing power spectrum. Combining data from z ˜ 7 to 11.6 using the SKA2-Low telescope model, we find constraints comparable to sample variance in the range L < 1000, even for survey areas as small as 25 deg2.

Power profiles of single vision and multifocal soft contact lenses.

PubMed

Wagner, Sandra; Conrad, Fabian; Bakaraju, Ravi C; Fedtke, Cathleen; Ehrmann, Klaus; Holden, Brien A

2015-02-01

The purpose of this study was to investigate the optical zone power profile of the most commonly prescribed soft contact lenses to assess their potential impact on peripheral refractive error and hence myopia progression. The optical power profiles of six single vision and ten multifocal contact lenses of five manufacturers in the powers -1.00 D, -3.00 D, and -6.00 D were measured using the SHSOphthalmic (Optocraft GmbH, Erlangen, Germany). Instrument repeatability was also investigated. Instrument repeatability was dependent on the distance from the optical centre, manifesting unreliable data for the central 1mm of the optic zone. Single vision contact lens measurements of -6.00 D lenses revealed omafilcon A having the most negative spherical aberration, lotrafilcon A having the least. Somofilcon A had the highest minus power and lotrafilcon A the biggest deviation in positive direction, relative to their respective labelled powers. Negative spherical aberration occurred for almost all of the multifocal contact lenses, including the centre-distance designs etafilcon A bifocal and omafilcon A multifocal. Lotrafilcon B and balafilcon A seem to rely predominantly on the spherical aberration component to provide multifocality. Power profiles of single vision soft contact lenses varied greatly, many having a negative spherical aberration profile that would exacerbate myopia. Some lens types and powers are affected by large intra-batch variability or power offsets of more than 0.25 dioptres. Evaluation of power profiles of multifocal lenses was derived that provides helpful information for prescribing lenses for presbyopes and progressing myopes. Copyright © 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Planck intermediate results. XLI. A map of lensing-induced B-modes

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davis, R. J.; de Bernardis, P.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Doré, O.; Ducout, A.; Dupac, X.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gruppuso, A.; Gudmundsson, J. E.; Harrison, D. L.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hornstrup, A.; Hovest, W.; Hurier, G.; Jaffe, A. H.; Jones, W. C.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Leonardi, R.; Levrier, F.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Meinhold, P. R.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-12-01

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced an all-sky template map of the lensing-induced B-modes using a real-space algorithm that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. It will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.

BIASES IN PHYSICAL PARAMETER ESTIMATES THROUGH DIFFERENTIAL LENSING MAGNIFICATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Er Xinzhong; Ge Junqiang; Mao Shude, E-mail: xer@nao.cas.cn

2013-06-20

We study the lensing magnification effect on background galaxies. Differential magnification due to different magnifications of different source regions of a galaxy will change the lensed composite spectra. The derived properties of the background galaxies are therefore biased. For simplicity, we model galaxies as a superposition of an axis-symmetric bulge and a face-on disk in order to study the differential magnification effect on the composite spectra. We find that some properties derived from the spectra (e.g., velocity dispersion, star formation rate, and metallicity) are modified. Depending on the relative positions of the source and the lens, the inferred results canmore » be either over- or underestimates of the true values. In general, for an extended source at strong lensing regions with high magnifications, the inferred physical parameters (e.g., metallicity) can be strongly biased. Therefore, detailed lens modeling is necessary to obtain the true properties of the lensed galaxies.« less

Planar Diffractive Lenses: Fundamentals, Functionalities, and Applications.

PubMed

Huang, Kun; Qin, Fei; Liu, Hong; Ye, Huapeng; Qiu, Cheng-Wei; Hong, Minghui; Luk'yanchuk, Boris; Teng, Jinghua

2018-06-01

Traditional objective lenses in modern microscopy, based on the refraction of light, are restricted by the Rayleigh diffraction limit. The existing methods to overcome this limit can be categorized into near-field (e.g., scanning near-field optical microscopy, superlens, microsphere lens) and far-field (e.g., stimulated emission depletion microscopy, photoactivated localization microscopy, stochastic optical reconstruction microscopy) approaches. However, they either operate in the challenging near-field mode or there is the need to label samples in biology. Recently, through manipulation of the diffraction of light with binary masks or gradient metasurfaces, some miniaturized and planar lenses have been reported with intriguing functionalities such as ultrahigh numerical aperture, large depth of focus, and subdiffraction-limit focusing in far-field, which provides a viable solution for the label-free superresolution imaging. Here, the recent advances in planar diffractive lenses (PDLs) are reviewed from a united theoretical account on diffraction-based focusing optics, and the underlying physics of nanofocusing via constructive or destructive interference is revealed. Various approaches of realizing PDLs are introduced in terms of their unique performances and interpreted by using optical aberration theory. Furthermore, a detailed tutorial about applying these planar lenses in nanoimaging is provided, followed by an outlook regarding future development toward practical applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Detections of Planets in Binaries Through the Channel of Chang–Refsdal Gravitational Lensing Events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, Cheongho; Shin, In-Gu; Jung, Youn Kil

Chang–Refsdal (C–R) lensing, which refers to the gravitational lensing of a point mass perturbed by a constant external shear, provides a good approximation in describing lensing behaviors of either a very wide or a very close binary lens. C–R lensing events, which are identified by short-term anomalies near the peak of high-magnification lensing light curves, are routinely detected from lensing surveys, but not much attention is paid to them. In this paper, we point out that C–R lensing events provide an important channel to detect planets in binaries, both in close and wide binary systems. Detecting planets through the C–Rmore » lensing event channel is possible because the planet-induced perturbation occurs in the same region of the C–R lensing-induced anomaly and thus the existence of the planet can be identified by the additional deviation in the central perturbation. By presenting the analysis of the actually observed C–R lensing event OGLE-2015-BLG-1319, we demonstrate that dense and high-precision coverage of a C–R lensing-induced perturbation can provide a strong constraint on the existence of a planet in a wide range of planet parameters. The sample of an increased number of microlensing planets in binary systems will provide important observational constraints in giving shape to the details of planet formation, which have been restricted to the case of single stars to date.« less

Statistics of Dark Matter Halos from Gravitational Lensing.

PubMed

Jain; Van Waerbeke L

2000-02-10

We present a new approach to measure the mass function of dark matter halos and to discriminate models with differing values of Omega through weak gravitational lensing. We measure the distribution of peaks from simulated lensing surveys and show that the lensing signal due to dark matter halos can be detected for a wide range of peak heights. Even when the signal-to-noise ratio is well below the limit for detection of individual halos, projected halo statistics can be constrained for halo masses spanning galactic to cluster halos. The use of peak statistics relies on an analytical model of the noise due to the intrinsic ellipticities of source galaxies. The noise model has been shown to accurately describe simulated data for a variety of input ellipticity distributions. We show that the measured peak distribution has distinct signatures of gravitational lensing, and its non-Gaussian shape can be used to distinguish models with different values of Omega. The use of peak statistics is complementary to the measurement of field statistics, such as the ellipticity correlation function, and is possibly not susceptible to the same systematic errors.

Probabilities for gravitational lensing by point masses in a locally inhomogeneous universe

NASA Technical Reports Server (NTRS)

Isaacson, Jeffrey A.; Canizares, Claude R.

1989-01-01

Probability functions for gravitational lensing by point masses that incorporate Poisson statistics and flux conservation are formulated in the Dyer-Roeder construction. Optical depths to lensing for distant sources are calculated using both the method of Press and Gunn (1973) which counts lenses in an otherwise empty cone, and the method of Ehlers and Schneider (1986) which projects lensing cross sections onto the source sphere. These are then used as parameters of the probability density for lensing in the case of a critical (q0 = 1/2) Friedmann universe. A comparison of the probability functions indicates that the effects of angle-averaging can be well approximated by adjusting the average magnification along a random line of sight so as to conserve flux.

HERSCHEL-ATLAS: TOWARD A SAMPLE OF {approx}1000 STRONGLY LENSED GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonzalez-Nuevo, J.; Lapi, A.; Bressan, S.

2012-04-10

While the selection of strongly lensed galaxies (SLGs) with 500 {mu}m flux density S{sub 500} > 100 mJy has proven to be rather straightforward, for many applications it is important to analyze samples larger than the ones obtained when confining ourselves to such a bright limit. Moreover, only by probing to fainter flux densities is it possible to exploit strong lensing to investigate the bulk of the high-z star-forming galaxy population. We describe HALOS (the Herschel-ATLAS Lensed Objects Selection), a method for efficiently selecting fainter candidate SLGs, reaching a surface density of {approx_equal} 1.5-2 deg{sup -2}, i.e., a factor ofmore » about 4-6 higher than that at the 100 mJy flux limit. HALOS will allow the selection of up to {approx}1000 candidate SLGs (with amplifications {mu} {approx}> 2) over the full H-ATLAS survey area. Applying HALOS to the H-ATLAS Science Demonstration Phase field ({approx_equal} 14.4 deg{sup 2}) we find 31 candidate SLGs, whose candidate lenses are identified in the VIKING near-infrared catalog. Using the available information on candidate sources and candidate lenses we tentatively estimate a {approx_equal} 72% purity of the sample. As expected, the purity decreases with decreasing flux density of the sources and with increasing angular separation between candidate sources and lenses. The redshift distribution of the candidate lensed sources is close to that reported for most previous surveys for lensed galaxies, while that of candidate lenses extends to redshifts substantially higher than found in the other surveys. The counts of candidate SLGs are also in good agreement with model predictions. Even though a key ingredient of the method is the deep near-infrared VIKING photometry, we show that H-ATLAS data alone allow the selection of a similarly deep sample of candidate SLGs with an efficiency close to 50%; a slightly lower surface density ({approx_equal} 1.45 deg{sup -2}) can be reached with a {approx}70% efficiency.« less

Integrated quadruple stress echocardiography.

PubMed

Picano, Eugenio; Morrone, Doralisa; Scali, Maria C; Huqi, Alda; Coviello, Katia; Ciampi, Quirino

2018-04-11

Stress Echocardiography (SE) is an established diagnostic technique. For 40 years, the cornerstone of the technique has been the detection of regional wall motion abnormalities (RWMA), due to the underlying physiologically-relevant epicardial coronary artery stenosis. In the last decade, three new parameters (more objective than RWMA) have shown the potential to integrate and comple- ment RWMA: 1- B-lines, also known as ultrasound lung comets, as a marker of extra-vascular lung water, measured using lung ultrasound with the 4-site simplified scan symmetrically of the antero- lateral thorax on the third intercostal space, from mid-axillary to anterior axillary and mid- clavicular line; 2-left ventricular contractile reserve (LVCR), assessed as the peak stress/rest ratio of left ventricular force, also known as elastance (systolic arterial pressure by cuff sphygmomanome- ter/end-systolic volume from 2D echocardiography); 3- coronary flow velocity reserve (CFVR) on left anterior descending coronary artery, calculated as peak stress/rest ratio of diastolic peak flow velocity assessed using pulsed-wave Doppler. The 4 parameters (RWMA, B-lines, LVCR and CFVR) now converge conceptually, logistically, and methodologically in the Integrated Quadruple (IQ)-SE. IQ-SE optimizes the versatility of SE to include in a one-stop shop the core "ABCD" (Asynergy+B-lines+Contractile reserve+Doppler flowmetry) protocol. It allows a synoptic assess- ment of parameters mirroring the epicardial artery stenosis (RWMA), interstitial lung water (B- lines), myocardial function (LVCR) and small coronary vessels (CFVR). Each variable has a clear clinical correlate, different and complementary to all others: RWMA identify an ischemic vs non- ischemic heart; B-lines a wet vs dry lung; LVCR a strong vs weak heart; CFVR a warm vs cold heart. IQ-SE is highly feasible, with minimal increase in the imaging and analysis time, and obvi- ous diagnostic and prognostic impact also beyond coronary artery

Mechanically triggered solute uptake in soft contact lenses.

PubMed

Tavazzi, Silvia; Ferraro, Lorenzo; Fagnola, Matteo; Cozza, Federica; Farris, Stefano; Bonetti, Simone; Simonutti, Roberto; Borghesi, Alessandro

2015-06-01

Molecular arrangement plays a role in the diffusion of water and solutes across soft contact lenses. In particular, the uptake of solutes in hydrated contact lenses can occur as long as free water is available for diffusion. In this work, we investigated the effect of mechanical vibrations of low frequency (200 Hz) on the solute uptake. Hyaluronan, a polysaccharide of ophthalmic use, was taken as example of solute of interest. For a specific water-hydrated hydrogel material, differential scanning calorimetry experiments showed that a large fraction of the hydration water accounted for loosely-bound water, both before and after one week of daily-wear of the lenses. The size (of the order of magnitude of few hundreds of nanometers) of hyaluronan in aqueous solution was found to be less than the size of the pores of the lens observed by scanning electron microscopy. However, solute uptake in already-hydrated lenses was negligible by simple immersion, while a significant increase occurred under mechanical vibrations of 200 Hz, thus providing experimental evidence of mechanically triggered enhanced solute uptake, which is attributed to the release of interfacial loosely-bound water. Also other materials were taken into consideration. However, the effectiveness of mechanical vibrations for hyaluronan uptake is restricted to lenses containing interfacial loosely-bound water. Indeed, loosely-bound water is expected to be bound to the polymer with bonding energies of the order of magnitude of 10-100 J/g, which are compatible with the energy input supplied by the vibrations. Copyright © 2015 Elsevier B.V. All rights reserved.

Power Profiles of Commercial Multifocal Soft Contact Lenses.

PubMed

Kim, Eon; Bakaraju, Ravi C; Ehrmann, Klaus

2017-02-01

To evaluate the optical power profiles of commercially available soft multifocal contact lenses and compare their optical designs. The power profiles of 38 types of multifocal contact lenses-three lenses each-were measured in powers +6D, +3D, +1D, -1D, -3D, and -6D using NIMO TR1504 (Lambda-X, Belgium). All lenses were measured in phosphate buffered saline across 8 mm optic zone diameter. Refractive index of each lens material was measured using CLR 12-70 (Index Instruments, UK), which was used for converting measured power in the medium to in-air radial power profiles. Three basic types of power profiles were identified: center-near, center-distance, and concentric-zone ring-type designs. For most of the lens types, the relative plus with respect to prescription power was lower than the corresponding spectacle add. For some lens types, the measured power profiles were shifted by up to 1D across the power range relative to their labeled power. Most of the lenses were designed with noticeable amounts of spherical aberration. The sign and magnitude of spherical aberration can either be power dependent or consistent across the power range. Power profiles can vary widely between the different lens types; however, certain similarities were also observed between some of the center-near designs. For the more recently released lens types, there seems to be a trend emerging to reduce the relative plus with respect to prescription power, include negative spherical aberration, and keep the power profiles consistent across the power range.

Direct shear mapping - a new weak lensing tool

NASA Astrophysics Data System (ADS)

de Burgh-Day, C. O.; Taylor, E. N.; Webster, R. L.; Hopkins, A. M.

2015-08-01

We have developed a new technique called direct shear mapping (DSM) to measure gravitational lensing shear directly from observations of a single background source. The technique assumes the velocity map of an unlensed, stably rotating galaxy will be rotationally symmetric. Lensing distorts the velocity map making it asymmetric. The degree of lensing can be inferred by determining the transformation required to restore axisymmetry. This technique is in contrast to traditional weak lensing methods, which require averaging an ensemble of background galaxy ellipticity measurements, to obtain a single shear measurement. We have tested the efficacy of our fitting algorithm with a suite of systematic tests on simulated data. We demonstrate that we are in principle able to measure shears as small as 0.01. In practice, we have fitted for the shear in very low redshift (and hence unlensed) velocity maps, and have obtained null result with an error of ±0.01. This high-sensitivity results from analysing spatially resolved spectroscopic images (i.e. 3D data cubes), including not just shape information (as in traditional weak lensing measurements) but velocity information as well. Spirals and rotating ellipticals are ideal targets for this new technique. Data from any large Integral Field Unit (IFU) or radio telescope is suitable, or indeed any instrument with spatially resolved spectroscopy such as the Sydney-Australian-Astronomical Observatory Multi-Object Integral Field Spectrograph (SAMI), the Atacama Large Millimeter/submillimeter Array (ALMA), the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) and the Square Kilometer Array (SKA).

Gap Junctional Coupling in Lenses from α8 Connexin Knockout Mice

PubMed Central

Baldo, George J.; Gong, Xiaohua; Martinez-Wittinghan, Francisco J.; Kumar, Nalin M.; Gilula, Norton B.; Mathias, Richard T.

2001-01-01

Lens fiber cell gap junctions contain α3 (Cx46) and α8 (Cx50) connexins. To examine the roles of the two different connexins in lens physiology, we have genetically engineered mice lacking either α3 or α8 connexin. Intracellular impedance studies of these lenses were used to measure junctional conductance and its sensitivity to intracellular pH. In Gong et al. 1998, we described results from α3 connexin knockout lenses. Here, we present original data from α8 connexin knockout lenses and a comparison with the previous results. The lens has two functionally distinct domains of fiber cell coupling. In wild-type mouse lenses, the outer shell of differentiating fibers (see 1, DF) has an average coupling conductance per area of cell–cell contact of ∼1 S/cm2, which falls to near zero when the cytoplasm is acidified. In the inner core of mature fibers (see 1, MF), the average coupling conductance is ∼0.4 S/cm2, and is insensitive to acidification of the cytoplasm. Both connexin isoforms appear to contribute about equally in the DF since the coupling conductance for either heterozygous knockout (+/−) was ∼70% of normal and 30–40% of the normal for both −/− lenses. However, their contribution to the MF was different. About 50% of the normal coupling conductance was found in the MF of α3 +/− lenses. In contrast, the coupling of MF in the α8 +/− lenses was the same as normal. Moreover, no coupling was detected in the MF of α3 −/− lenses. Together, these results suggest that α3 connexin alone is responsible for coupling MF. The pH- sensitive gating of DF junctions was about the same in wild-type and α3 connexin −/− lenses. However, in α8 −/− lenses, the pure α3 connexin junctions did not gate closed in the response to acidification. Since α3 connexin contributes about half the coupling conductance in DF of wild-type lenses, and that conductance goes to zero when the cytoplasmic pH drops, it appears α8 connexin regulates the gating

What is Gravitational Lensing? (LBNL Summer Lecture Series)

ScienceCinema

Leauthaud, Alexie [Univ. of California, Berkeley, CA (United States). Berkeley Center for Cosmological Physics (BCCP); Nakajima, Reiko [Univ. of California, Berkeley, CA (United States). Berkeley Center for Cosmological Physics (BCCP)

2018-05-04

Summer Lecture Series 2009: Gravitational lensing is explained by Einstein's general theory of relativity: galaxies and clusters of galaxies, which are very massive objects, act on spacetime by causing it to become curved. Alexie Leauthaud and Reiko Nakajima, astrophysicists with the Berkeley Center for Cosmological Physics, will discuss how scientists use gravitational lensing to investigate the nature of dark energy and dark matter in the universe.

What is Gravitational Lensing? (LBNL Summer Lecture Series)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leauthaud, Alexie; Nakajima, Reiko

2009-07-28

Summer Lecture Series 2009: Gravitational lensing is explained by Einstein's general theory of relativity: galaxies and clusters of galaxies, which are very massive objects, act on spacetime by causing it to become curved. Alexie Leauthaud and Reiko Nakajima, astrophysicists with the Berkeley Center for Cosmological Physics, will discuss how scientists use gravitational lensing to investigate the nature of dark energy and dark matter in the universe.

Creating School Change: Discovering a Choice of Lenses for the School Administrator.

ERIC Educational Resources Information Center

Amatea, Ellen S.; And Others

1996-01-01

Proposes a variety of epistemological lenses for viewing the school change process for school administrators' use. Applies these lenses in an actual case study depicting school change, illustrating how administrators can shift focus, position, and mode of inquiry from their usual rational viewpoint. Analyzes implications of using such lenses for…

Precise strong lensing mass profile of the CLASH galaxy cluster MACS 2129

NASA Astrophysics Data System (ADS)

Monna, A.; Seitz, S.; Balestra, I.; Rosati, P.; Grillo, C.; Halkola, A.; Suyu, S. H.; Coe, D.; Caminha, G. B.; Frye, B.; Koekemoer, A.; Mercurio, A.; Nonino, M.; Postman, M.; Zitrin, A.

2017-04-01

We present a detailed strong lensing (SL) mass reconstruction of the core of the galaxy cluster MACS J2129.4-0741 (zcl = 0.589) obtained by combining high-resolution Hubble Space Telescope photometry from the CLASH (Cluster Lensing And Supernovae survey with Hubble) survey with new spectroscopic observations from the CLASH-VLT (Very Large Telescope) survey. A background bright red passive galaxy at zsp = 1.36, sextuply lensed in the cluster core, has four radial lensed images located over the three central cluster members. Further 19 background lensed galaxies are spectroscopically confirmed by our VLT survey, including 3 additional multiple systems. A total of 31 multiple images are used in the lensing analysis. This allows us to trace with high precision the total mass profile of the cluster in its very inner region (R < 100 kpc). Our final lensing mass model reproduces the multiple images systems identified in the cluster core with high accuracy of 0.4 arcsec. This translates to a high-precision mass reconstruction of MACS 2129, which is constrained at a level of 2 per cent. The cluster has Einstein parameter ΘE = (29 ± 4) arcsec and a projected total mass of Mtot(<ΘE) = (1.35 ± 0.03) × 1014 M⊙ within such radius. Together with the cluster mass profile, we provide here also the complete spectroscopic data set for the cluster members and lensed images measured with VLT/Visible Multi-Object Spectrograph within the CLASH-VLT survey.

Democracy and environment as references for quadruple and quintuple helix innovation systems

NASA Astrophysics Data System (ADS)

Carayannis, Elias G.; Campbell, David F. J.; Orr, Barron J.

2015-04-01

The perspective of democracy and the ecological context define key references for knowledge production and innovation in innovation systems. Particularly under conditions of environmental change where enhancing the potential for adaptation is critical, this requires a closer look at ecological responsibility and sensitivity in the different innovation models and governance regimes. The "Quintuple Helix" innovation model is an approach that stresses the necessary socio-ecological transition of society and economy by adding an environment helix to an innovation system already made up of three (university-industry-government) or four (civil society relations) helices in a way that supports adaptation by incorporating global warming as both a challenge to and a driver of innovation. There is the proposition that knowledge production and innovation co-evolve with democracy (Carayannis and Campbell, 2014). In the Triple Helix model (Etzkowitz and Leydesdorff, 2000) the existence of a democracy does not appear to be necessary for knowledge production and innovation. However, the Quadruple Helix (Carayannis and Campbell, 2009, 2010 and 2014) is defined and represented by additional key attributes and components: "media-based and culture-based public", "civil society" and "arts, artistic research and arts-based innovation" (Bast, Carayannis and Campbell, 2015). Implications of this are that the fourth helix in the Quadruple Helix innovation systems brings in and represents the perspective of "dimension of democracy" or the "context of democracy" for knowledge in general and knowledge production and innovation in more particular. Within theories of democracy there is a competition between narrow and broader concepts of democracy (Campbell, 2013). This is particularly true when democracy is to be understood to transcend more substantially the narrow understanding of being primarily based on or being primarily rooted in government institutions (within a Triple Helix

The CASTLES Imaging Survey of Gravitational Lenses

NASA Astrophysics Data System (ADS)

Peng, C. Y.; Falco, E. E.; Lehar, J.; Impey, C. D.; Kochanek, C. S.; McLeod, B. A.; Rix, H.-W.

1997-12-01

The CASTLES survey (Cfa-Arizona-(H)ST-Lens-Survey) is imaging most known small-separation gravitational lenses (or lens candidates), using the NICMOS camera (mostly H-band) and the WFPC2 (V and I band) on HST. To date nearly half of the IR imaging survey has been completed. The main goals are: (1) to search for lens galaxies where none have been directly detected so far; (2) obtain photometric redshift estimates (VIH) for the lenses where no spectroscopic redshifts exist; (3) study and model the lens galaxies in detail, in part to study the mass distribution within them, in part to identify ``simple" systems that may permit accurate time delay estimates for H_0; (3) measure the M/L evolution of the sample of lens galaxies with look-back time (to z ~ 1); (4) determine directly which fraction of sources are lensed by ellipticals vs. spirals. We will present the survey specifications and the images obtained so far.

Gravitational Lensing: Einstein's unfinished symphony

NASA Astrophysics Data System (ADS)

Treu, Tommaso; Ellis, Richard S.

2015-01-01

Gravitational lensing - the deflection of light rays by gravitating matter - has become a major tool in the armoury of the modern cosmologist. Proposed nearly a hundred years ago as a key feature of Einstein's theory of general relativity, we trace the historical development since its verification at a solar eclipse in 1919. Einstein was apparently cautious about its practical utility and the subject lay dormant observationally for nearly 60 years. Nonetheless there has been rapid progress over the past twenty years. The technique allows astronomers to chart the distribution of dark matter on large and small scales thereby testing predictions of the standard cosmological model which assumes dark matter comprises a massive weakly-interacting particle. By measuring the distances and tracing the growth of dark matter structure over cosmic time, gravitational lensing also holds great promise in determining whether the dark energy, postulated to explain the accelerated cosmic expansion, is a vacuum energy density or a failure of general relativity on large scales. We illustrate the wide range of applications which harness the power of gravitational lensing, from searches for the earliest galaxies magnified by massive clusters to those for extrasolar planets which temporarily brighten a background star. We summarise the future prospects with dedicated ground and space-based facilities designed to exploit this remarkable physical phenomenon.

Efficient dielectric metasurface collimating lenses for mid-infrared quantum cascade lasers.

PubMed

Arbabi, Amir; Briggs, Ryan M; Horie, Yu; Bagheri, Mahmood; Faraon, Andrei

2015-12-28

Light emitted from single-mode semiconductor lasers generally has large divergence angles, and high numerical aperture lenses are required for beam collimation. Visible and near infrared lasers are collimated using aspheric glass or plastic lenses, yet collimation of mid-infrared quantum cascade lasers typically requires more costly aspheric lenses made of germanium, chalcogenide compounds, or other infrared-transparent materials. Here we report mid-infrared dielectric metasurface flat lenses that efficiently collimate the output beam of single-mode quantum cascade lasers. The metasurface lenses are composed of amorphous silicon posts on a flat sapphire substrate and can be fabricated at low cost using a single step conventional UV binary lithography. Mid-infrared radiation from a 4.8 μm distributed-feedback quantum cascade laser is collimated using a polarization insensitive metasurface lens with 0.86 numerical aperture and 79% transmission efficiency. The collimated beam has a half divergence angle of 0.36° and beam quality factor of M2=1.02.

Efficient dielectric metasurface collimating lenses for mid-infrared quantum cascade lasers

DOE PAGES

Arbabi, Amir; Briggs, Ryan M.; Horie, Yu; ...

2015-01-01

Light emitted from single-mode semiconductor lasers generally has large divergence angles, and high numerical aperture lenses are required for beam collimation. Visible and near infrared lasers are collimated using aspheric glass or plastic lenses, yet collimation of mid-infrared quantum cascade lasers typically requires more costly aspheric lenses made of germanium, chalcogenide compounds, or other infrared-transparent materials. We report mid-infrared dielectric metasurface flat lenses that efficiently collimate the output beam of single-mode quantum cascade lasers. The metasurface lenses are composed of amorphous silicon posts on a flat sapphire substrate and can be fabricated at low cost using a single step conventionalmore » UV binary lithography. Mid-infrared radiation from a 4.8 μm distributed-feedback quantum cascade laser is collimated using a polarization insensitive metasurface lens with 0.86 numerical aperture and 79% transmission efficiency. The collimated beam has a half divergence angle of 0.36° and beam quality factor of M² =1.02.« less

Glutathione Preservation during Storage of Rat Lenses in Optisol-GS and Castor Oil

PubMed Central

Holm, Thomas; Brøgger-Jensen, Martin Rocho; Johnson, Leif; Kessel, Line

2013-01-01

Background Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. The aim of the study was to examine the effects of Optisol-GS and castor oil on lens condition, determined from their ability to maintain glutathione concentrations. Methodology/Principal Findings Rat lenses were stored in the two types of storage media at varying time intervals up to 3 days. Glutathione concentration was afterwards determined in an enzymatic detection assay, specific for both reduced and oxidized forms. Lenses removed immediately after death exhibited a glutathione concentration of 4.70±0.29 mM. In vitro stored lenses in Optisol-GS lost glutathione quickly, ending with a concentration of 0.60±0.34 mM after 3 days while castor oil stored lenses exhibited a slower decline and ended at 3 times the concentration. A group of lenses were additionally stored under post mortem conditions within the host for 6 hours before its removal. Total glutathione after 6 hours was similar to that of lenses removed immediately after death, but with altered GSH and GSSG concentrations. Subsequent storage of these lenses in media showed changes similar to those in the first series of experiments, albeit to a lesser degree. Conclusions/Significance It was determined that storage in Optisol-GS resulted in a higher loss of glutathione than lenses stored in castor oil. Storage for more than 12 hours reduced glutathione to half its original concentration, and was considered unusable after 24 hours. PMID:24260265

Planck intermediate results: XLI. A map of lensing-induced B-modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ade, P. A. R.; Aghanim, N.; Ashdown, M.

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced in this paper an all-sky template map of the lensing-induced B-modes using a real-space algorithmmore » that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. Finally, it will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.« less

Planck intermediate results: XLI. A map of lensing-induced B-modes

DOE PAGES

Ade, P. A. R.; Aghanim, N.; Ashdown, M.; ...

2016-12-12

The secondary cosmic microwave background (CMB) B-modes stem from the post-decoupling distortion of the polarization E-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced B-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB B-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization E-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced in this paper an all-sky template map of the lensing-induced B-modes using a real-space algorithmmore » that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) B-mode map can be used to measure the lensing B-mode power spectrum at multipoles up to 2000. In particular, when cross-correlating with the B-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced B-mode power spectrum measurement at a significance level of 12σ, which agrees with the theoretical expectation derived from the Planck best-fit Λ cold dark matter model. This unique nearly all-sky secondary B-mode template, which includes the lensing-induced information from intermediate to small (10 ≲ ℓ ≲ 1000) angular scales, is delivered as part of the Planck 2015 public data release. Finally, it will be particularly useful for experiments searching for primordial B-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB B-modes.« less

Strong Lens Models for Massive Galaxy Clusters in the Reionization Lensing Cluster Survey

NASA Astrophysics Data System (ADS)

Cerny, Catherine; Sharon, Keren; Coe, Dan A.; Paterno-Mahler, Rachel; Jones, Christine; Czakon, Nicole G.; Umetsu, Keiichi; Stark, Daniel; Bradley, Larry D.; Trenti, Michele; Johnson, Traci; Bradac, Marusa; Dawson, William; Rodney, Steven A.; Strolger, Louis-Gregory; RELICS Team

2017-01-01

We present strong lensing models for five galaxy clusters from the Planck SZ cluster catalog as a part of the Reionization Lensing Cluster Survey (RELICS), a program that seeks to constrain the galaxy luminosity function past z~9 by conducting a wide field survey of massive galaxy clusters with HST (GO-14096, PI: Coe). The strong gravitational lensing effects of these clusters significantly magnify background galaxies, which enhances our ability to discover the large numbers of high redshift galaxies at z~9-12 needed to create a representative sample. We use strong lensing models for these clusters to study their mass distribution and magnification, which allows us to quantify the lensing effect on the background galaxies. These models can then be utilized in the RELICS survey in order to identify high redshift galaxy candidates that may be lensed by the clusters. The intrinsic properties of these galaxy candidates can be derived by removing the lensing effect as predicted by our models, which will meet the science goals of the RELICS survey. We use HST WFC3 and ACS imaging to create lensing models for the clusters RXC J0142.9+4438, ACO-2537, ACO-2163, RXCJ2211.7-0349, and ACT-CLJ0102-49151.

Oxidation enhances calpain-induced turbidity in young rat lenses.

PubMed

Nakamura, Y; Fukiage, C; Azuma, M; Shearer, T R

1999-07-01

To determine if oxidation enhances turbidity after proteolysis of rat lens crystallins by the calcium-activated protease calpain (EC 3.4.22.17). Total soluble proteins from young rat lens were hydrolyzed for 24 hr by endogenous lens calpain, and the proteins were further incubated with the oxidant diamide for up to 7 days. Turbidity was measured daily at 405 nm. To measure proteolysis and turbidity in cultured lenses, rat lenses were cultured for 6 days in low calcium medium and diamide. The lenses were then photographed to assess transmission of light. SDS-PAGE and immunoblotting assessed proteolysis of crystallins, alpha-spectrin, and activation of calpain. Appreciable in vitro turbidity occurred in soluble proteins from young rat lenses after proteolysis of crystallins by endogenous calpain. Calpain inhibitor E64, or anti-oxidants DTE and GSH, inhibited this turbidity. On the other hand, the oxidant diamide markedly enhanced calpain-induced turbidity. Cultured rat lenses showed elevated intralenticular calcium and proteolysis of crystallins by calpain, but no nuclear cataract. Addition of diamide to the culture medium caused development of nuclear cataract. Diamide enhanced turbidity only when crystallins were proteolyzed. Oxidation may be one of the factors promoting light scatter and insolubilization after proteolysis. These data are consistent with the hypothesis that proteolysis of crystallins from young rat lens may expose cysteine residues, which are then oxidized, become insoluble and scatter light.

Star Formation at z = 2.481 in the Lensed Galaxy SDSS J1110+6459. II. What is Missed at the Normal Resolution of the Hubble Space Telescope?

NASA Astrophysics Data System (ADS)

Rigby, J. R.; Johnson, T. L.; Sharon, K.; Whitaker, K.; Gladders, M. D.; Florian, M.; Lotz, J.; Bayliss, M.; Wuyts, E.

2017-07-01

For lensed galaxy SGAS J111020.0+645950.8 at redshift z = 2.481, which is magnified by a factor of 28 ± 8, we analyze the morphology of star formation, as traced by rest-frame ultraviolet emission, in both the highly magnified source plane and simulations of how this galaxy would appear without lensing magnification. Were this galaxy not lensed, but rather drawn from a Hubble Space Telescope deep field, we would conclude that almost all its star formation arises from an exponential disk (Sérsic index of 1.0 ± 0.4) with an effective radius of {r}e=2.7+/- 0.3 {kpc} measured from two-dimensional fitting to F606W using Galfit, and {r}e=1.9+/- 0.1 {kpc} measured by fitting a radial profile to F606W elliptical isophotes. At the normal spatial resolution of the deep fields, there is no sign of clumpy star formation within SGAS J111020.0+645950.8. However, the enhanced spatial resolution enabled by gravitational lensing tells a very different story; much of the star formation arises in two dozen clumps with sizes of r = 30-50 pc spread across the 7 kpc length of the galaxy. The color and spatial distribution of the diffuse component suggests that still-smaller clumps are unresolved. Despite this clumpy, messy morphology, the radial profile is still well-characterized by an exponential profile. In this lensed galaxy, stars are forming in complexes with sizes well below 100 pc such sizes are wholly unexplored by surveys of galaxy evolution at 1< z< 3.

On Using a Space Telescope to Detect Weak-lensing Shear

NASA Astrophysics Data System (ADS)

Tung, Nathan; Wright, Edward

2017-11-01

Ignoring redshift dependence, the statistical performance of a weak-lensing survey is set by two numbers: the effective shape noise of the sources, which includes the intrinsic ellipticity dispersion and the measurement noise, and the density of sources that are useful for weak-lensing measurements. In this paper, we provide some general guidance for weak-lensing shear measurements from a “generic” space telescope by looking for the optimum wavelength bands to maximize the galaxy flux signal-to-noise ratio (S/N) and minimize ellipticity measurement error. We also calculate an effective galaxy number per square degree across different wavelength bands, taking into account the density of sources that are useful for weak-lensing measurements and the effective shape noise of sources. Galaxy data collected from the ultra-deep UltraVISTA Ks-selected and R-selected photometric catalogs (Muzzin et al. 2013) are fitted to radially symmetric Sérsic galaxy light profiles. The Sérsic galaxy profiles are then stretched to impose an artificial weak-lensing shear, and then convolved with a pure Airy Disk PSF to simulate imaging of weak gravitationally lensed galaxies from a hypothetical diffraction-limited space telescope. For our model calculations and sets of galaxies, our results show that the peak in the average galaxy flux S/N, the minimum average ellipticity measurement error, and the highest effective galaxy number counts all lie around the K-band near 2.2 μm.

Lensing convergence in galaxy clustering in ΛCDM and beyond

NASA Astrophysics Data System (ADS)

Villa, Eleonora; Di Dio, Enea; Lepori, Francesca

2018-04-01

We study the impact of neglecting lensing magnification in galaxy clustering analyses for future galaxy surveys, considering the ΛCDM model and two extensions: massive neutrinos and modifications of General Relativity. Our study focuses on the biases on the constraints and on the estimation of the cosmological parameters. We perform a comprehensive investigation of these two effects for the upcoming photometric and spectroscopic galaxy surveys Euclid and SKA for different redshift binning configurations. We also provide a fitting formula for the magnification bias of SKA. Our results show that the information present in the lensing contribution does improve the constraints on the modified gravity parameters whereas the lensing constraining power is negligible for the ΛCDM parameters. For photometric surveys the estimation is biased for all the parameters if lensing is not taken into account. This effect is particularly significant for the modified gravity parameters. Conversely for spectroscopic surveys the bias is below one sigma for all the parameters. Our findings show the importance of including lensing in galaxy clustering analyses for testing General Relativity and to constrain the parameters which describe its modifications.

Gravitational lenses: The current sample, recent results, and continuing searches

NASA Technical Reports Server (NTRS)

Hewitt, Jacqueline N.

1991-01-01

Gravitational lensing is one of the topics in astrophysics that was quite extensively discussed over time before it was actually discovered. Ten years after the discovery of the first one, it is interesting to note how the field has developed. After an initial slow rate of discovery, the last few years have seen an explosion in the number of reported cases. Attention was drawn to the first few cases because quasars at the same red shift, with similar optical spectra, were observed with angular separations of only a few arc seconds. Most observational effort has been devoted to searching for new candidate lens systems and carefully measuring their properties, both to test whether they are indeed lensed and to provide constraints for modeling. A classification of the lenses is into rings, arcs, multiples, and doubles, where the progression is from sources close to the optical axis to far from the optical axis. The known candidate systems are listed. The searches for gravitational lenses are proving to be successful, and more lenses continue to be discovered serendipitously. Many searches are under way, along with instruments that will routinely increase the resolution of astronomical imaging.

Source Plane Reconstruction of the Bright Lensed Galaxy RCSGA 032727-132609

NASA Technical Reports Server (NTRS)

Sharon, Keren; Gladders, Michael D.; Rigby, Jane R.; Wuyts, Eva; Koester, Benjamin P.; Bayliss, Matthew B.; Barrientos, L. Felipe

2011-01-01

We present new HST/WFC3 imaging data of RCS2 032727-132609, a bright lensed galaxy at z=1.7 that is magnified and stretched by the lensing cluster RCS2 032727-132623. Using this new high-resolution imaging, we modify our previous lens model (which was based on ground-based data) to fully understand the lensing geometry, and use it to reconstruct the lensed galaxy in the source plane. This giant arc represents a unique opportunity to peer into 100-pc scale structures in a high redshift galaxy. This new source reconstruction will be crucial for a future analysis of the spatially-resolved rest-UV and rest-optical spectra of the brightest parts of the arc.

Dense arrays of millimeter-sized glass lenses fabricated at wafer-level.

PubMed

Albero, Jorge; Perrin, Stéphane; Bargiel, Sylwester; Passilly, Nicolas; Baranski, Maciej; Gauthier-Manuel, Ludovic; Bernard, Florent; Lullin, Justine; Froehly, Luc; Krauter, Johann; Osten, Wolfgang; Gorecki, Christophe

2015-05-04

This paper presents the study of a fabrication technique of lenses arrays based on the reflow of glass inside cylindrical silicon cavities. Lenses whose sizes are out of the microfabrication standards are considered. In particular, the case of high fill factor arrays is discussed in detail since the proximity between lenses generates undesired effects. These effects, not experienced when lenses are sufficiently separated so that they can be considered as single items, are corrected by properly designing the silicon cavities. Complete topographic as well as optical characterizations are reported. The compatibility of materials with Micro-Opto-Electromechanical Systems (MOEMS) integration processes makes this technology attractive for the miniaturization of inspection systems, especially those devoted to imaging.

Lensing of the CMB: non-Gaussian aspects.

PubMed

Zaldarriaga, M

2001-06-01

We compute the small angle limit of the three- and four-point function of the cosmic microwave background (CMB) temperature induced by the gravitational lensing effect by the large-scale structure of the universe. We relate the non-Gaussian aspects presented in this paper with those in our previous studies of the lensing effects. We interpret the statistics proposed in previous work in terms of different configurations of the four-point function and show how they relate to the statistic that maximizes the S/N.

Features of optical surfaces of multifocal diffractive-refractive eye lenses

NASA Astrophysics Data System (ADS)

Lenkova, G. A.

2017-09-01

This paper considers shape features of the surface structures of multifocal intraocular lenses (IOLs), which, unlike bifocal IOLs, generate additional foci or extends the depth of focus, which not only corrects near and far vision but also provides good vision at intermediate distances. Expansion of the field of clear vision is achieved due to the effects of diffraction, interference, and refraction (change in the radius of curvature of the lens surface). The optical characteristics of the most famous multifocal IOLs (trifocal and quadrafocal lenses and lenses with extended focal area) are given.

Efficiency and coherence preservation studies of Be refractive lenses for XFELO application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolodziej, Tomasz; Stoupin, Stanislav; Grizolli, Walan

2018-02-14

Performance tests of parabolic beryllium refractive lenses, considered as X-ray focusing elements in the future X-ray free-electron laser oscillator (XFELO), are reported. Single and double refractive lenses were subject to X-ray tests, which included: surface profile, transmissivity measurements, imaging capabilities and wavefront distortion with grating interferometry. Optical metrology revealed that surface profiles were close to the design specification in terms of the figure and roughness. The transmissivity of the lenses is >94% at 8 keV and >98% at 14.4 and 18 keV. These values are close to the theoretical values of ideal lenses. Images of the bending-magnet source obtained withmore » the lenses were close to the expected ones and did not show any significant distortion. Grating interferometry revealed that the possible wavefront distortions produced by surface and bulk lens imperfections were on the level of ~λ/60 for 8 keV photons. Thus the Be lenses can be succesfully used as focusing and beam collimating elements in the XFELO.« less

What is Gravitational Lensing?(LBNL Summer Lecture Series)

ScienceCinema

Alexie, Leauthaud; Reiko, Nakajima [Berkeley Center for Cosmological Physics, Berkely, California, United States

2017-12-09

July 28, 2009 Berkeley Lab summer lecture: Gravitational lensing is explained by Einstein's general theory of relativity: galaxies and clusters of galaxies, which are very massive objects, act on spacetime by causing it to become curved. Alexie Leauthaud and Reiko Nakajima, astrophysicists with the Berkeley Center for Cosmological Physics, will discuss how scientists use gravitational lensing to investigate the nature of dark energy and dark matter in the universe.

Adhesion of Pseudomonas aeruginosa and Staphylococcus epidermidis to silicone-hydrogel contact lenses.

PubMed

Henriques, Mariana; Sousa, Cláudia; Lira, Madalena; Elisabete, M; Oliveira, Real; Oliveira, Rosário; Azeredo, Joana

2005-06-01

The purpose of this study is to compare the adhesion capabilities of the most important etiologic agents of microbial ocular infection to the recently available silicone-hydrogel lenses with those to a conventional hydrogel lens. In vitro static adhesion assays of Pseudomonas aeruginosa 10,145, Staphylococcus epidermidis 9142 (biofilm-positive), and 12,228 (biofilm-negative) to two extended-wear silicone-hydrogel lenses (balafilcon A and lotrafilcon A), a daily wear silicone-hydrogel lens (galyfilcon A) and a conventional hydrogel (etafilcon A) were performed. To interpret the adhesion results, lens surface relative hydrophobicity was assessed by water contact angle measurements. P. aeruginosa and S. epidermidis 9142 exhibited greater adhesion capabilities to the extended wear silicone-hydrogel lenses than to the daily wear silicone- and conventional hydrogel lenses (p < 0.05). No statistical differences were found between the adhesion extent of these strains to galyfilcon A and etafilcon A. The biofilm negative strain of S. epidermidis adhered in larger extents to the silicone-hydrogel lenses than to the conventional hydrogel (p < 0.05), but in much lower amounts than the biofilm-positive strain. The water contact angle measurements revealed that the extended wear silicone-hydrogel lenses are hydrophobic, whereas the daily wear silicone- and conventional hydrogel lenses are hydrophilic. As a result of their hydrophobicity, the extended wear silicone-hydrogel lenses (lotrafilcon A and balafilcon A) may carry higher risk of microbial contamination than both the hydrophilic daily wear silicone-hydrogel lens, galyfilcon A and the conventional hydrogel lens, etafilcon A.

In vitro power profiles of daily disposable contact lenses.

PubMed

Belda-Salmerón, Lurdes; Madrid-Costa, David; Ferrer-Blasco, Teresa; García-Lázaro, Santiago; Montés-Micó, Robert

2013-10-01

To evaluate and compare the distribution of refractive power within the optic zone of different soft contact lenses and to investigate the effect of lens decentration on the power profiles. The Nimo TR1504 instrument was used to measure the optical power across different aperture diameters (from 1.5mm to 5.5mm in steps of 0.5mm) of four daily disposable contact lenses: DAILIES TOTAL1, Proclear 1-Day, SofLens daily disposable and 1-DAY ACUVUE MOIST. Measurements were performed using a wet cell. Power data were evaluated when contact lenses were in its centered position and after inducing different amounts of lens decentration (from 0.2mm to 1.0mm in steps of 0.2mm). All contact lenses showed an increase - more negative - in lens power with distance from the lens center. The amount of change varied depending on the lens. It was about 10% of lens power for DAILIES TOTAL1 (-0.29diopters (D)), SofLens daily disposable (-0.36D), and Proclear 1-Day (-0.32D) whereas 1-DAY ACUVUE MOIST showed a percentage variation of 3.3% (-0.10D). After inducing a lens decentration up to 1mm, the power curves were shifted in the negative direction. However, the change obtained in lens power compared with well-centered position was always lower than a quarter of diopter both for all the lenses and aperture diameters. Our results showed a variation of the refractive power from the lens center, becoming more negative toward the periphery, with a negligible effect of the decentration for all disposable contact lenses studied. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Direct Laser Writing of Nanophotonic Structures on Contact Lenses.

PubMed

AlQattan, Bader; Yetisen, Ali K; Butt, Haider

2018-04-24

Contact lenses are ubiquitous biomedical devices used for vision correction and cosmetic purposes. Their application as quantitative analytical devices is highly promising for point-of-care diagnostics. However, it is a challenge to integrate nanoscale features into commercial contact lenses for application in low-cost biosensors. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm, 3 ns pulse, 240 mJ) in holographic interference patterning mode was utilized to produce optical nanostructures over the surface of a hydrogel contact lens. One-dimensional (925 nm) and two-dimensional (925 nm × 925 nm) nanostructures were produced on contact lenses and analyzed by spectroscopy and angle-resolve measurements. The holographic properties of these nanostructures were tested in ambient moisture, fully hydrated, and artificial tear conditions. The measurements showed a rapid tuning of optical diffraction from these nanostructures from 41 to 48°. The nanostructures were patterned near the edges of the contact lens to avoid any interference and obstruction to the human vision. The formation of 2D nanostructures on lenses increased the diffraction efficiency by more than 10%. The versatility of the holographic laser ablation method was demonstrated by producing four different 2D nanopattern geometries on contact lenses. Hydrophobicity of the contact lens was characterized by contact angle measurements, which increased from 59.0° at pristine condition to 62.5° at post-nanofabrication. The holographic nanostructures on the contact lens were used to sense the concentration of Na + ions. Artificial tear solution was used to simulate the conditions in dry eye syndrome, and nanostructures on the contact lenses were used to detect the electrolyte concentration changes (±47 mmol L -1 ). Nanopatterns on a contact lens may be used to sense other ocular diseases in early stages at point-of-care settings.

Broad spectrum antimicrobial activity of melimine covalently bound to contact lenses.

PubMed

Dutta, Debarun; Cole, Nerida; Kumar, Naresh; Willcox, Mark D P

2013-01-07

To develop a stable antimicrobial contact lens, which is effective against the International Organization for Standardization (ISO) panel microorganisms, Acanthamoeba castellanii and drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Melimine was covalently incorporated into etafilcon A lenses. The amount of peptide present on the lens surface was quantified using amino acid analysis. After coating, the heat stability (121°C), lens surface hydrophobicity (by captive bubble), and in vitro cytotoxicity to mouse L929 cells of the lenses were investigated. Antimicrobial activity against the micro-organisms was evaluated by viable plate count and fluorescence microscopy, measuring the proportion of cell death compared with control lenses with no melimine. The most effective concentration was determined to be 152 ± 44 μg lens(-1) melimine on the lens surface. After coating, lenses were relatively hydrophilic and were nontoxic to mammalian cells. The activity remained high after autoclaving (e.g., 3.1, 3.9, 1.2, and 1.0 log inhibition against P. aeruginosa, S. aureus, A. castellanii, and Fusarium solani, respectively). Fluorescence microscopy confirmed significantly reduced (P < 0.001) adhesion of viable bacteria to melimine contact lenses. Viable count confirmed that lenses were active against all the bacteria and fungi from the ISO panel, Acanthamoeba and gave at least 2 log inhibition against all the multidrug resistant S. aureus and P. aeruginosa strains. Melimine may offer excellent potential for development as a broad spectrum antimicrobial coating for contact lenses, showing activity against all the bacterial and fungal ISO panel microorganisms, Acanthamoeba, and antibiotic resistant strains of P. aeruginosa and S. aureus.

On the Contribution of Large-Scale Structure to Strong Gravitational Lensing

NASA Astrophysics Data System (ADS)

Faure, C.; Kneib, J.-P.; Hilbert, S.; Massey, R.; Covone, G.; Finoguenov, A.; Leauthaud, A.; Taylor, J. E.; Pires, S.; Scoville, N.; Koekemoer, Anton M.

2009-04-01

We study the correlation between the locations of galaxy-galaxy strong-lensing candidates and tracers of large-scale structure from both weak lensing (WL) or X-ray emission. The Cosmological Evolution Survey (COSMOS) is a unique data set, combining deep, high resolution and contiguous imaging in which strong lenses have been discovered, plus unparalleled multiwavelength coverage. To help interpret the COSMOS data, we have also produced mock COSMOS strong- and WL observations, based on ray-tracing through the Millennium Simulation. In agreement with the simulations, we find that strongly lensed images with the largest angular separations are found in the densest regions of the COSMOS field. This is explained by a prevalence among the lens population in dense environments of elliptical galaxies with high total-to-stellar mass ratios, which can deflect light through larger angles. However, we also find that the overall fraction of elliptical galaxies with strong gravitational lensing is independent of the local mass density; this observation is not true of the simulations, which predict an increasing fraction of strong lenses in dense environments. The discrepancy may be a real effect, but could also be explained by various limitations of our analysis. For example, our visual search of strong lens systems could be incomplete and suffer from selection bias; the luminosity function of elliptical galaxies may differ between our real and simulated data; or the simplifying assumptions and approximations used in our lensing simulations may be inadequate. Work is therefore ongoing. Automated searches for strong lens systems will be particularly important in better constraining the selection function.

Spectral transmittance of UV-blocking soft contact lenses: a comparative study.

PubMed

Rahmani, Saeed; Mohammadi Nia, Mohadeseh; Akbarzadeh Baghban, Alireza; Nazari, Mohammad Reza; Ghassemi-Broumand, Mohammad

2014-12-01

Three major parts of sunlight consist of visible, ultraviolet and infrared radiation. Exposure to ultraviolet radiation (UVR) can result in a spectrum of skin and ocular diseases. UV-blocking contact lenses help provide protection against harmful UV radiation. We studied the ultraviolet and visible light rays transmission in some soft UV-blocking contact lenses. Four available tinted soft lenses (Acuvue Moist, Zeiss CONTACT Day 30 Air spheric, Pretty Eyes and Sauflon 56 UV) have been evaluated for UV and visible transmission. One-way ANOVA testing was performed to establish is there a statistically significant difference between the UV regions and visible spectra means for the contact lenses (α=0.05). Pretty Eyes, Zeiss CONTACT, Acuvue Moist and Sauflon 56 UV showed UV-B transmittance value of 0.65%, 10.69%, 1.22%, and 5.78%, respectively. Pretty Eyes and Acuvue Moist had UV-A transmittance values of 32% and 34%, Sauflon 56 UV and Zeiss CONTACT had transmittance values of 48% and 43%, respectively. All of the studied lenses transmitted at least 94.6% on the visible spectrum. The results of the one-way ANOVA statistical analysis show that a statistically significant difference exists within the group of contact lenses tested for the visible (p<0.001), UV-B (p<0.001) and UV-A (p<0.001) portions of the spectrum (α=0.05). Acuvue Moist has the best UV-blocking property and also visible transmission between other tested contact lenses in this study. Copyright © 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Evidence of lensing of the cosmic microwave background by dark matter halos.

PubMed

Madhavacheril, Mathew; Sehgal, Neelima; Allison, Rupert; Battaglia, Nick; Bond, J Richard; Calabrese, Erminia; Caligiuri, Jerod; Coughlin, Kevin; Crichton, Devin; Datta, Rahul; Devlin, Mark J; Dunkley, Joanna; Dünner, Rolando; Fogarty, Kevin; Grace, Emily; Hajian, Amir; Hasselfield, Matthew; Hill, J Colin; Hilton, Matt; Hincks, Adam D; Hlozek, Renée; Hughes, John P; Kosowsky, Arthur; Louis, Thibaut; Lungu, Marius; McMahon, Jeff; Moodley, Kavilan; Munson, Charles; Naess, Sigurd; Nati, Federico; Newburgh, Laura; Niemack, Michael D; Page, Lyman A; Partridge, Bruce; Schmitt, Benjamin; Sherwin, Blake D; Sievers, Jon; Spergel, David N; Staggs, Suzanne T; Thornton, Robert; Van Engelen, Alexander; Ward, Jonathan T; Wollack, Edward J

2015-04-17

We present evidence of the gravitational lensing of the cosmic microwave background by 10(13) solar mass dark matter halos. Lensing convergence maps from the Atacama Cosmology Telescope Polarimeter (ACTPol) are stacked at the positions of around 12 000 optically selected CMASS galaxies from the SDSS-III/BOSS survey. The mean lensing signal is consistent with simulated dark matter halo profiles and is favored over a null signal at 3.2σ significance. This result demonstrates the potential of microwave background lensing to probe the dark matter distribution in galaxy group and galaxy cluster halos.

The effects of two different types of bandage contact lenses on the healthy canine eye.

PubMed

Braus, Barbara Katharina; Riedler, Daniela; Tichy, Alexander; Spergser, Joachim; Schwendenwein, Ilse

2018-02-06

To compare two types of bandage contact lenses on the healthy canine eye. Six healthy Beagles. Two different types of bandage contact lenses (single sized human silicone contact lens 'PureVision 2' (Bausch & Lomb Incorporated, Rochester, NY, USA) and specially designed veterinary hydrogel contact lens 'AcriVet Pat D' (Bausch & Lomb Incorporated) were placed in 12 eyes of healthy Beagle dogs. Retention times and the effects of the lenses regarding irritation of the eye, changes in tear production, impact of contact lenses on tonometric readings, and cytologic and microbiological alterations of the canine eye were investigated. Mean retention times for veterinary hydrogel lenses with special dimensions were significantly shorter (2 days) than for one size human silicon lenses (8.8 days). Irritation scores were overall low for both types of lenses apart from one human lens causing severe irritation and keratoconjunctivitis as a sequel to folding and displacement. Tear production remained stable in human contact lenses. Intraocular pressure readings with a contact lens in place were only slightly altered; the most accurate readings were obtained through a human lens with an applanation tonometer. Cytology revealed a slight, nonsignificant increase in neutrophilic granulocytes with both types of lenses; the microflora did not change significantly. Human silicone lenses have significantly longer retention times and are less expensive than veterinary hydrogel lenses. In regard to irritation, bacterial growth and inflammation, both types of lenses can be recommended for use in canine eyes. © 2018 American College of Veterinary Ophthalmologists.

Gravitational lensing of gravitational waves: a statistical perspective

NASA Astrophysics Data System (ADS)

Li, Shun-Sheng; Mao, Shude; Zhao, Yuetong; Lu, Youjun

2018-05-01

In this paper, we study the strong gravitational lensing of gravitational waves (GWs) from a statistical perspective, with particular focus on the high frequency GWs from stellar binary black hole coalescences. These are most promising targets for ground-based detectors such as Advanced Laser Interferometer Gravitational Wave Observatory (aLIGO) and the proposed Einstein Telescope (ET) and can be safely treated under the geometrical optics limit for GW propagation. We perform a thorough calculation of the lensing rate, by taking account of effects caused by the ellipticity of lensing galaxies, lens environments, and magnification bias. We find that in certain GW source rate scenarios, we should be able to observe strongly lensed GW events once per year (˜1 yr-1) in the aLIGO survey at its design sensitivity; for the proposed ET survey, the rate could be as high as ˜80 yr-1. These results depend on the estimate of GW source abundance, and hence can be correspondingly modified with an improvement in our understanding of the merger rate of stellar binary black holes. We also compute the fraction of four-image lens systems in each survey, predicting it to be ˜30 per cent for the aLIGO survey and ˜6 per cent for the ET survey. Finally, we evaluate the possibility of missing some images due to the finite survey duration, by presenting the probability distribution of lensing time delays. We predict that this selection bias will be insignificant in future GW surveys, as most of the lens systems ({˜ } 90{per cent}) will have time delays less than ˜1 month, which will be far shorter than survey durations.

Weak Lensing Results of the Merging Cluster A1758

NASA Technical Reports Server (NTRS)

Markevitch, M.; Gonzalez, A. H.; Bradac, M.

2011-01-01

Here we present the weak lensing results of A1758, which is known to have four cluster members undergoing two separate mergers, A1758N and A1758S. Weak lensing results of A1758N agree with previous weak lensing results of clusters lE0657-558 (Bullet cluster) and MACS J0025.4-1222, whose X-ray gas components were found to be largely separated from their clusters' gravitational potentials. A1758N has a geometry that is different from previously published mergers in that one of its X-ray peaks overlays the corresponding gravitational potential and the other X-ray peak is well separated from its cluster's gravitational potential.

Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome.

PubMed

Maulvi, Furqan A; Soni, Tejal G; Shah, Dinesh O

2015-01-01

Current dry eye treatment includes delivering comfort enhancing agents to the eye via eye drops, but low residence time of eye drops leads to low bioavailability. Frequent administration leads to incompliance in patients, so there is a great need for medical device such as contact lenses to treat dry eye. Studies in the past have demonstrated the efficacy of hyaluronic acid (HA) in the treatment of dry eyes using eye drops. In this paper, we present two methods to load HA in hydrogel contact lenses, soaking method and direct entrapment. The contact lenses were characterized by studying their optical and physical properties to determine their suitability as extended wear contact lenses. HA-laden hydrogel contact lenses prepared by soaking method showed release up to 48 h with acceptable physical and optical properties. Hydrogel contact lenses prepared by direct entrapment method showed significant sustained release in comparison to soaking method. HA entrapped in hydrogels resulted in reduction in % transmittance, sodium ion permeability and surface contact angle, while increase in % swelling. The impact on each of these properties was proportional to HA loading. The batch with 200-μg HA loading showed all acceptable values (parameters) for contact lens use. Results of cytotoxicity study indicated the safety of hydrogel contact lenses. In vivo pharmacokinetics studies in rabbit tear fluid showed dramatic increase in HA mean residence time and area under the curve with lenses in comparison to eye drop treatment. The study demonstrates the promising potential of delivering HA through contact lenses for the treatment of dry eye syndrome.

Probing small-scale structure in galaxies with strong gravitational lensing

NASA Astrophysics Data System (ADS)

Congdon, Arthur Benjamin

We use gravitational lensing to study the small-scale distribution of matter in galaxies. First, we examine galaxies and their dark matter halos. Roughly half of all observed four-image quasar lenses have image flux ratios that differ from the values predicted by simple lens potentials. We show that smooth departures from elliptical symmetry fail to explain anomalous radio fluxes, strengthening the case for dark matter substructure. Our results have important implications for the "missing satellites'' problem. We then consider how time delays between lensed images can be used to identify lens galaxies containing small-scale structure. We derive an analytic relation for the time delay between the close pair of images in a "fold'' lens, and perform Monte Carlo simulations to investigate the utility of time delays for probing small- scale structure in realistic lens populations. We compare our numerical predictions with systems that have measured time delays and discover two anomalous lenses. Next, we consider microlensing, where stars in the lens galaxy perturb image magnifications. This is relevant at optical wavelengths, where the size of the lensed source is comparable to the Einstein radius of a typical star. Our simulations of negative-parity images show that raising the fraction of dark matter relative to stars increases image flux variability for small sources, and decreases it for large sources. This suggests that quasar accretion disks and broad-emission-line regions may respond differently to microlensing. We also consider extended sources with a range of ellipticities, which has relevance to a population of inclined accretion disks. Depending on their orientation, more elongated sources lead to more rapid variability, which may complicate the interpretation of microlensing light curves. Finally, we consider prospects for observing strong lensing by the supermassive black hole at the center of the Milky Way, Sgr A*. Assuming a black hole on the million

COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses: XVI. Time delays for the quadruply imaged quasar DES J0408–5354 with high-cadence photometric monitoring* [COSMOGRAIL XVI: Time delays for the quadruply imaged quasar DES J0408–5354 with high-cadence photometric monitoring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Courbin, F.; Bonvin, V.; Buckley-Geer, E.

Here, we present time-delay measurements for the new quadruple imaged quasar DES J0408–5354, the first quadruple imaged quasar found in the Dark Energy Survey (DES). Our result is made possible by implementing a new observational strategy using almost daily observations with the MPIA 2.2 m telescope at La Silla observatory and deep exposures reaching a signal-to-noise ratio of about 1000 per quasar image. This data qualityallows us to catch small photometric variations (a few mmag rms) of the quasar, acting on temporal scales much shorter than microlensing, and hence making the time delay measurement very robust against microlensing. In onlymore » seven months we very accurately measured one of the time delays in DES J0408–5354: Δt(AB) = –112.1 ± 2.1 days (1.8%) using only the MPIA 2.2 m data. In combination with data taken with the 1.2 m Euler Swiss telescope, we also measured two delays involving the D component of the system Δt(AD) = –155.5 ± 12.8 days (8.2%) and Δt(BD) = –42.4 ± 17.6 days (41%), where all the error bars include systematics. Turning these time delays into cosmological constraints will require deep Hubble Space Telescope (HST) imaging or ground-based adaptive optics (AO), and information on the velocity field of the lensing galaxy.« less

COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses: XVI. Time delays for the quadruply imaged quasar DES J0408–5354 with high-cadence photometric monitoring* [COSMOGRAIL XVI: Time delays for the quadruply imaged quasar DES J0408–5354 with high-cadence photometric monitoring

DOE PAGES

Courbin, F.; Bonvin, V.; Buckley-Geer, E.; ...

2018-01-09

Here, we present time-delay measurements for the new quadruple imaged quasar DES J0408–5354, the first quadruple imaged quasar found in the Dark Energy Survey (DES). Our result is made possible by implementing a new observational strategy using almost daily observations with the MPIA 2.2 m telescope at La Silla observatory and deep exposures reaching a signal-to-noise ratio of about 1000 per quasar image. This data qualityallows us to catch small photometric variations (a few mmag rms) of the quasar, acting on temporal scales much shorter than microlensing, and hence making the time delay measurement very robust against microlensing. In onlymore » seven months we very accurately measured one of the time delays in DES J0408–5354: Δt(AB) = –112.1 ± 2.1 days (1.8%) using only the MPIA 2.2 m data. In combination with data taken with the 1.2 m Euler Swiss telescope, we also measured two delays involving the D component of the system Δt(AD) = –155.5 ± 12.8 days (8.2%) and Δt(BD) = –42.4 ± 17.6 days (41%), where all the error bars include systematics. Turning these time delays into cosmological constraints will require deep Hubble Space Telescope (HST) imaging or ground-based adaptive optics (AO), and information on the velocity field of the lensing galaxy.« less

Postoperative inflammatory reactions to intraocular lense sterilized with ethylene-oxide.

PubMed

Stark, W J; Rosenblum, P; Maumenee, A E; Cowan, C L

1980-05-01

Postoperative inflammatory complications after intraocular lens implantation have increased since we have been using lenses manufactured by American companies and sterilized with ethylene-oxide, as compared with lenses from European companies sterilized by sodium hydroxide. The possible sources of this complication are discussed.

Cosmetic Cleansing Oil Absorption by Soft Contact Lenses in Dry and Wet Conditions.

PubMed

Tsukiyama, Junko; Miyamoto, Yuko; Kodama, Aya; Fukuda, Masahiko; Shimomura, Yoshikazu

2017-09-01

Previous reports showed that cosmetic cleansing oil for removing makeup, which contains mineral oil and surfactant, can deform some silicone hydrogel contact lenses (SHCLs) when applied directly to the lenses, although plasma-coated SHCLs (lotrafilcon A and B) were not affected. In the present study, we investigated hydrogel lenses and SHCLs in both wet and dry conditions. Several brands of hydrogel and SHCLs were immersed in a cleansing oil solution containing Sudan Black B for 5 min under wet and dry conditions. The lenses under the wet condition were simply picked up from the saline, whereas those under the dry condition were blotted with paper wipes. After immersing, the excess solution remaining on the lenses was removed by finger rubbing with a multipurpose solution. The lenses were then examined using a stereomicroscope, and their mean brightness was measured and compared. The cosmetic cleansing oil was not absorbed by the hydrogel lenses under wet or dry conditions. However, four of seven brands of SHCLs absorbed the cosmetic cleansing oil under both conditions (dry and wet), whereas asmofilcon A absorbed it only under the dry condition. Lotrafilcon B and delefilcon A did not absorb cleansing oil even under the dry condition. Hydrogel lenses resist cosmetic cleansing oil. However, SHCLs have different degrees of resistance depending on the lens material. Some SHCLs absorbed cosmetic cleansing oil more under dry conditions than under wet conditions.

Lensing-induced morphology changes in CMB temperature maps in modified gravity theories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munshi, D.; Coles, P.; Hu, B.

2016-04-01

Lensing of the Cosmic Microwave Background (CMB) changes the morphology of pattern of temperature fluctuations, so topological descriptors such as Minkowski Functionals can probe the gravity model responsible for the lensing. We show how the recently introduced two-to-two and three-to-one kurt-spectra (and their associated correlation functions), which depend on the power spectrum of the lensing potential, can be used to probe modified gravity theories such as f ( R ) theories of gravity and quintessence models. We also investigate models based on effective field theory, which include the constant-Ω model, and low-energy Hořava theories. Estimates of the cumulative signal-to-noise formore » detection of lensing-induced morphology changes, reaches O(10{sup 3}) for the future planned CMB polarization mission COrE{sup +}. Assuming foreground removal is possible to ℓ{sub max}=3000, we show that many modified gravity theories can be rejected with a high level of significance, making this technique comparable in power to galaxy weak lensing or redshift surveys. These topological estimators are also useful in distinguishing lensing from other scattering secondaries at the level of the four-point function or trispectrum. Examples include the kinetic Sunyaev-Zel'dovich (kSZ) effect which shares, with lensing, a lack of spectral distortion. We also discuss the complication of foreground contamination from unsubtracted point sources.« less

Evaluation of optical changes of three types of lenses: hard PMMA, hydrogel, and heparin surface modified hard lenses effected by silicone oil, used clinically as a substitute of the vitreous body.

PubMed

Prokopowicz, Magdalena; Czarnobaj, Katarzyna; Raczyńska, Krystyna; Łukasiak, Jerzy; Przyjazny, Andrzej

2002-01-01

The objective of these investigations was an in vitro evaluation whether silicone oil OXANE of viscosity 5700 cSt clinically used in eye surgery as a substitute of the vitreous body, being in contact with an artificial polymer lens used as an implant of human lens, causes the changes in its optical properties. The paper presents the results of spectral analysis of transmission of visible (VIS) radiation of three types of artificial lenses: hard PMMA, hydrogel, heparin surface modified (HSM) hard PMMA, and the same lenses damaged by YAG laser radiation with an energy increasing from 1.7 mJ to 3.7 mJ, exposed to clinically applied silicone oil. The studies were carried out, in two-week intervals, over a period of 20 weeks. Hard PMMA and HSM lenses were found not to have changed their optical properties after 20 weeks of exposure to silicone oil. The measured transmittance values were within the range of instrumental error (+/- 1%). Optical properties of hydrogel lenses exposed to silicone oils deteriorated with exposure and after 20-week exposure to silicone oil the average transmittance value decreased by about 18%, reaching its final value of 67.08 +/- 2.37% (RSD = 5.56%). A minimal decrease of the initial transmittance values was observed only for the lenses exposed to laser radiation of highest energy (3.7 mJ). After completed exposure to silicone oil, two kinds of lenses were found to have a slightly improved transmittance: hard PMMA lenses by about 4% and HSM lenses by about 2%. On the other hand, in case of hydrogel lenses the deterioration of optical properties to the extent comparable to that of hydrogel lenses not damaged by laser radiation was observed.

Lenses that provide the transformation between two given wavefronts

NASA Astrophysics Data System (ADS)

Criado, C.; Alamo, N.

2016-12-01

We give an original method to design four types of lenses solving the following problems: focusing a given wavefront in a given point, and performing the transformation between two arbitrary incoming and outgoing wavefronts. The method to design the lenses profiles is based on the optical properties of the envelopes of certain families of Cartesian ovals of revolution.

30 CFR 18.66 - Tests of windows and lenses.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Tests of windows and lenses. 18.66 Section 18... Tests § 18.66 Tests of windows and lenses. (a) Impact tests. A 4-pound cylindrical weight with a 1-inch-diameter hemispherical striking surface shall be dropped (free fall) to strike the window or lens in its...

Anisotropic Galaxy-Galaxy Lensing in the Illustris-1 Simulation

NASA Astrophysics Data System (ADS)

Brainerd, Tereasa G.

2017-06-01

In Cold Dark Matter universes, the dark matter halos of galaxies are expected to be triaxial, leading to a surface mass density that is not circularly symmetric. In principle, this "flattening" of the dark matter halos of galaxies should be observable as an anisotropy in the weak galaxy-galaxy lensing signal. The degree to which the weak lensing signal is observed to be anisotropic, however, will depend strongly on the degree to which mass (i.e., the dark matter) is aligned with light in the lensing galaxies. That is, the anisotropy will be maximized when the major axis of the projected mass distribution is well aligned with the projected light distribution of the lens galaxies. Observational studies of anisotropic galaxy-galaxy lensing have found an anisotropic weak lensing signal around massive, red galaxies. Detecting the signal around blue, disky galaxies has, however, been more elusive. A possible explanation for this is that mass and light are well aligned within red galaxies and poorly aligned within blue galaxies (an explanation that is supported by studies of the locations of satellites of large, relatively isolated galaxies). Here we compute the weak lensing signal of isolated central galaxies in the Illustris-1 simulation. We compute the anisotropy of the weak lensing signal using two definitions of the geometry: [1] the major axis of the projected dark matter mass distribution and [2] the major axis of the projected stellar mass. On projected scales less than 15% of the virial radius, an anisotropy of order 10% is found for both definitions of the geometry. On larger scales, the anisotropy computed relative to the major axis of the projected light distribution is less than the anisotropy computed relative to the major axis of the projected dark matter. On projected scales of order the virial radius, the anisotropy obtained when using the major axis of the light is an order of magnitude less than the anisotropy obtained when using the major axis of the

Defect inspection of actuator lenses using swept-source optical coherence tomography

NASA Astrophysics Data System (ADS)

Lee, Jaeyul; Shirazi, Muhammad Faizan; Park, Kibeom; Jeon, Mansik; Kim, Jeehyun

2017-12-01

Actuator lens industries have gained an enormous interest with the enhancement of various latest communication devices, such as mobile phone and notebooks. The quality of the aforementioned devices can be degraded due to the internal defects of actuator lenses. Therefore, in this study, we implemented swept-source optical coherence tomography (SS-OCT) system to inspect defects of actuator lenses. Owing to the high-resolution of the SS-OCT system, defected foreign substances between the actuator lenses, defective regions of lenses and surface stains were more clearly distinguished through three-dimensional (3D) and two-dimensional (2D) cross-sectional OCT images. Therefore, the implemented SS-OCT system can be considered as a potential application to defect inspection of actuator lens.

Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks.

PubMed

Wildsoet, C; Wallman, J

1995-05-01

It is known that when hyperopic or myopic defocus is imposed on chick eyes by spectacle lenses, they rapidly compensate, becoming myopic or hyperopic respectively, by altering the depth of their vitreous chamber. Changes in two components--ocular length and choroidal thickness--underlie this rapid compensation. With monocular lens treatment, hyperopic defocus imposed by negative lenses resulted in substantially increased ocular elongation and a slight thinning of the choroid, both changes resulting in myopia; myopic defocus imposed by positive lenses resulted a dramatic increase in choroidal thickness, which pushed the retina forward toward the image plane, and a slight decrease in ocular elongation, both changes resulting in hyperopia. The refractive error after 5 days of lens wear correlated well with vitreous chamber depth, which reflected the changes in both choroidal thickness and ocular length. The degree of compensation for lenses was not affected by whether the fellow eye was covered or open. Both form-deprivation myopia and lens-induced myopia declined with age in parallel, but wearing a -15 D lens produced more myopia than did form deprivation. The spectacle lenses affected the refractive error not only of the lens-wearing eye, but also, to a much lesser degree, of the untreated fellow eye. At lens removal refractive errors were opposite in sign to the lense worn, and the subsequent changes in choroidal thickness and ocular length were also opposite to those that occurred when the lenses were in place. In this situation as well, effects of the spectacle lenses on the fellow eyes were observed. Eyes with no functional afferent connection to the brain because of either prior optic nerve section or intraocular tetrodotoxin injections showed compensatory changes to imposed defocus, but these were limited to compensation for imposed myopic defocus, at least for the eyes with optic nerve section. In addition, optic nerve section, but not tetrodotoxin treatment

Dexamethasone diffusion across contact lenses is inhibited by Staphylococcus epidermidis biofilms in vitro.

PubMed

Brothers, Kimberly M; Nau, Amy C; Romanowski, Eric G; Shanks, Robert M Q

2014-10-01

This study was designed to measure the impact of bacterial biofilms on diffusion of an ocular therapeutic through silicone hydrogel bandage lenses in vitro. An assay was designed to study the passage of a commonly used steroid, dexamethasone, through silicone hydrogel soft contact lenses. Diffused dexamethasone was measured using a spectrophotometer over a period of 18 hours and quantified using a standard curve. This assay was performed with control and Staphylococcus epidermidis biofilm-coated contact lenses comprised of lotrafilcon A and methafilcon. Biofilms were formed in brain heart infusion broth supplemented with D-glucose. The presented data validate a simple in vitro model that can be used to measure the penetration of a topical therapeutic through silicone hydrogel soft contact lenses. Using this model, we measured a reduction in dexamethasone diffusion up to 88% through S. epidermidis biofilm-coated silicone hydrogel lenses compared with control lenses. The results of this in vitro study demonstrate that bacterial biofilms impede dexamethasone diffusion through silicone hydrogel contact lenses and warrant future studies regarding the clinical benefit of using ocular therapeutics in the setting of bandage contact lens use for corneal epithelial defects.

Dexamethasone diffusion across contact lenses is inhibited by Staphylococcus epidermidis biofilms in vitro

PubMed Central

Brothers, Kimberly M.; Nau, Amy C.; Romanowski, Eric G.; Shanks, Robert M. Q.

2014-01-01

Purpose This study was designed to measure the impact of bacterial biofilms on diffusion of an ocular therapeutic through silicone hydrogel bandage lenses in vitro. Methods An assay was designed to study the passage of a commonly used steroid dexamethasone through the silicone hydrogel soft contact lenses. Diffused dexamethasone was measured using a spectrophotometer over a period of 18 hours and quantified using a standard curve. This assay was performed with control and Staphylococcus epidermidis biofilm-coated contact lenses composed of lotrafilcon A and methafilcon. Biofilms were formed in brain heart infusion broth supplemented with D-glucose. Results The presented data validate a simple in vitro model that can be used to measure penetration of a topical therapeutic through silicone hydrogel soft contact lenses. Using this model we measured a reduction of dexamethasone diffusion by up to 88% through S. epidermidis biofilm-coated silicon hydrogel lenses compared to control lenses. Conclusions The results of this in vitro study demonstrate that bacterial biofilms impede dexamethasone diffusion through silicon hydrogel contact lenses, and warrant future studies regarding the clinical benefit of using ocular therapeutics in the setting of bandage contact lens use for corneal epithelial defects. PMID:25090165

The epidemiology of microbial keratitis with silicone hydrogel contact lenses.

PubMed

Stapleton, Fiona; Keay, Lisa; Edwards, Katie; Holden, Brien

2013-01-01

It was widely anticipated that after the introduction of silicone hydrogel lenses, the risk of microbial keratitis would be lower than with hydrogel lenses because of the reduction in hypoxic effects on the corneal epithelium. Large-scale epidemiological studies have confirmed that the absolute and relative risk of microbial keratitis is unchanged with overnight use of silicone hydrogel materials. The key findings include the following: (1) The risk of infection with 30 nights of silicone hydrogel use is equivalent to 6 nights of hydrogel extended wear; (2) Occasional overnight lens use is associated with a greater risk than daily lens use; (3) The rate of vision loss due to corneal infection with silicone hydrogel contact lenses is similar to that seen in hydrogel lenses; (4) The spectrum of causative organisms is similar to that seen in hydrogel lenses, and the material type does not impact the corneal location of presumed microbial keratitis; and (5) Modifiable risk factors for infection include overnight lens use, the degree of exposure, failing to wash hands before lens handling, and storage case hygiene practice. The lack of change in the absolute risk of disease would suggest that exposure to large number of pathogenic organisms can overcome any advantages obtained from eliminating the hypoxic effects of contact lenses. Epidemiological studies remain important in the assessment of new materials and modalities. Consideration of an early adopter effect with studies involving new materials and modalities and further investigation of the impact of second-generation silicone hydrogel materials is warranted.

The effect of UV-blocking contact lenses as a therapy for canine chronic superficial keratitis.

PubMed

Denk, Nora; Fritsche, Jens; Reese, Sven

2011-05-01

To evaluate the effect of UV-blocking soft contact lenses in treatment for chronic superficial keratitus (CSK). Twenty six dogs with CSK were treated continuously with UV-blocking contact lenses for 6 months. A contact lens was placed on one eye of each dog; the other eye remained without a lens as a control eye. After this primary study, five of the dogs were further treated and they wore then contact lenses in both eyes. Continuously, all patients were concurrently treated topically with cyclosporine. The contact lenses were changed every 4 weeks and an ophthalmic examination performed. Evaluation criteria included corneal alterations as pigmentation, edema, pannus and vascularization. To determine the transmittance characteristics of the contact lenses before and after use, 32 contact lenses were measured with a UV-vis-NIR spectrophotometer. Pigmentation increased in eyes wearing lenses and in control eyes over the evaluation period of 6 months. Corneal edema increased in the eyes wearing lenses, but remained unaffected in the control eyes. A significant difference in the incidence of pannus and the extent of corneal vascularisation could not be evaluated. Adverse effects were noted in six cases (corneal edema and vascularisation, conjunctivitis, blepharospasm). All new lenses studied reduced UV-radiation to a safe level, whereas used lenses did not maintain their transmittance characteristics. No positive effect of UV-blocking contact lenses could be proven with the study design used. © 2011 American College of Veterinary Ophthalmologists.

Cluster richness-mass calibration with cosmic microwave background lensing

NASA Astrophysics Data System (ADS)

Geach, James E.; Peacock, John A.

2017-11-01

Identifying galaxy clusters through overdensities of galaxies in photometric surveys is the oldest1,2 and arguably the most economical and mass-sensitive detection method3,4, compared with X-ray5-7 and Sunyaev-Zel'dovich effect8 surveys that detect the hot intracluster medium. However, a perennial problem has been the mapping of optical `richness' measurements onto total cluster mass3,9-12. Emitted at a conformal distance of 14 gigaparsecs, the cosmic microwave background acts as a backlight to all intervening mass in the Universe, and therefore has been gravitationally lensed13-15. Experiments such as the Atacama Cosmology Telescope16, South Pole Telescope17-19 and the Planck20 satellite have now detected gravitational lensing of the cosmic microwave background and produced large-area maps of the foreground deflecting structures. Here we present a calibration of cluster optical richness at the 10% level by measuring the average cosmic microwave background lensing measured by Planck towards the positions of large numbers of optically selected clusters, detecting the deflection of photons by structures of total mass of order 1014 M⊙. Although mainly aimed at the study of larger-scale structures, the Planck estimate of the cosmic microwave background lensing field can be used to recover a nearly unbiased lensing signal for stacked clusters on arcminute scales15,21. This approach offers a clean measure of total cluster masses over most of cosmic history, largely independent of baryon physics.

Rotation of the cosmic microwave background polarization from weak gravitational lensing.

PubMed

Dai, Liang

2014-01-31

When a cosmic microwave background (CMB) photon travels from the surface of last scatter through spacetime metric perturbations, the polarization vector may rotate about its direction of propagation. This gravitational rotation is distinct from, and occurs in addition to, the lensing deflection of the photon trajectory. This rotation can be sourced by linear vector or tensor metric perturbations and is fully coherent with the curl deflection field. Therefore, lensing corrections to the CMB polarization power spectra as well as the temperature-polarization cross correlations due to nonscalar perturbations are modified. The rotation does not affect lensing by linear scalar perturbations, but needs to be included when calculations go to higher orders. We present complete results for weak lensing of the full-sky CMB power spectra by general linear metric perturbations, taking into account both deflection of the photon trajectory and rotation of the polarization. For the case of lensing by gravitational waves, we show that the B modes induced by the rotation largely cancel those induced by the curl component of deflection.

Application and System Design of Elastomer Based Optofluidic Lenses

NASA Astrophysics Data System (ADS)

Savidis, Nickolaos

Adaptive optic technology has revolutionized real time correction of wavefront aberrations. Optofluidic based applied optic devices have offered an opportunity to produce flexible refractive lenses in the correction of wavefronts. Fluidic lenses have superiority relative to their solid lens counterparts in their capabilities of producing tunable optical systems, that when synchronized, can produce real time variable systems with no moving parts. We have developed optofluidic fluidic lenses for applications of applied optical devices, as well as ophthalmic optic devices. The first half of this dissertation discusses the production of fluidic lenses as optical devices. In addition, the design and testing of various fluidic systems made with these components are evaluated. We begin with the creation of spherical or defocus singlet fluidic lenses. We then produced zoom optical systems with no moving parts by synchronizing combinations of these fluidic spherical lenses. The variable power zoom system incorporates two singlet fluidic lenses that are synchronized. The coupled device has no moving parts and has produced a magnification range of 0.1 x to 10 x or a 20 x magnification range. The chapter after fluidic zoom technology focuses on producing achromatic lens designs. We offer an analysis of a hybrid diffractive and refractive achromat that offers discrete achromatized variable focal lengths. In addition, we offer a design of a fully optofluidic based achromatic lens. By synchronizing the two membrane surfaces of the fluidic achromat we develop a design for a fluidic achromatic lens. The second half of this dissertation discusses the production of optofluidic technology in ophthalmic applications. We begin with an introduction to an optofluidic phoropter system. A fluidic phoropter is designed through the combination of a defocus lens with two cylindrical fluidic lenses that are orientated 45° relative to each other. Here we discuss the designs of the fluidic

The Use of Contact Lenses in Industrial Environments: An Assessment of Current Research and Policy.

ERIC Educational Resources Information Center

Connors, Terry

2001-01-01

Attempts to dispel rumors concerning contact lenses and tries to supply prudent-use practices for allowing contact lenses in industry and laboratories. Discusses federal regulations that impact the use of contact lenses in industry, policy statements from medical organizations on use of contact lenses in industrial environments, and the…

Pulsar emission amplified and resolved by plasma lensing in an eclipsing binary.

PubMed

Main, Robert; Yang, I-Sheng; Chan, Victor; Li, Dongzi; Lin, Fang Xi; Mahajan, Nikhil; Pen, Ue-Li; Vanderlinde, Keith; van Kerkwijk, Marten H

2018-05-01

Radio pulsars scintillate because their emission travels through the ionized interstellar medium along multiple paths, which interfere with each other. It has long been realized that, independent of their nature, the regions responsible for the scintillation could be used as 'interstellar lenses' to localize pulsar emission regions 1,2 . Most such lenses, however, resolve emission components only marginally, limiting results to statistical inferences and detections of small positional shifts 3-5 . As lenses situated close to their source offer better resolution, it should be easier to resolve emission regions of pulsars located in high-density environments such as supernova remnants 6 or binaries in which the pulsar's companion has an ionized outflow. Here we report observations of extreme plasma lensing in the 'black widow' pulsar, B1957+20, near the phase in its 9.2-hour orbit at which its emission is eclipsed by its companion's outflow 7-9 . During the lensing events, the observed radio flux is enhanced by factors of up to 70-80 at specific frequencies. The strongest events clearly resolve the emission regions: they affect the narrow main pulse and parts of the wider interpulse differently. We show that the events arise naturally from density fluctuations in the outer regions of the outflow, and we infer a resolution of our lenses that is comparable to the pulsar's radius, about 10 kilometres. Furthermore, the distinct frequency structures imparted by the lensing are reminiscent of what is observed for the repeating fast radio burst FRB 121102, providing observational support for the idea that this source is observed through, and thus at times strongly magnified by, plasma lenses 10 .

Pulsar emission amplified and resolved by plasma lensing in an eclipsing binary

NASA Astrophysics Data System (ADS)

Main, Robert; Yang, I.-Sheng; Chan, Victor; Li, Dongzi; Lin, Fang Xi; Mahajan, Nikhil; Pen, Ue-Li; Vanderlinde, Keith; van Kerkwijk, Marten H.

2018-05-01

Radio pulsars scintillate because their emission travels through the ionized interstellar medium along multiple paths, which interfere with each other. It has long been realized that, independent of their nature, the regions responsible for the scintillation could be used as `interstellar lenses' to localize pulsar emission regions1,2. Most such lenses, however, resolve emission components only marginally, limiting results to statistical inferences and detections of small positional shifts3-5. As lenses situated close to their source offer better resolution, it should be easier to resolve emission regions of pulsars located in high-density environments such as supernova remnants6 or binaries in which the pulsar's companion has an ionized outflow. Here we report observations of extreme plasma lensing in the `black widow' pulsar, B1957+20, near the phase in its 9.2-hour orbit at which its emission is eclipsed by its companion's outflow7-9. During the lensing events, the observed radio flux is enhanced by factors of up to 70-80 at specific frequencies. The strongest events clearly resolve the emission regions: they affect the narrow main pulse and parts of the wider interpulse differently. We show that the events arise naturally from density fluctuations in the outer regions of the outflow, and we infer a resolution of our lenses that is comparable to the pulsar's radius, about 10 kilometres. Furthermore, the distinct frequency structures imparted by the lensing are reminiscent of what is observed for the repeating fast radio burst FRB 121102, providing observational support for the idea that this source is observed through, and thus at times strongly magnified by, plasma lenses10.

ALMA observations of lensed Herschel sources: testing the dark matter halo paradigm

NASA Astrophysics Data System (ADS)

Amvrosiadis, A.; Eales, S. A.; Negrello, M.; Marchetti, L.; Smith, M. W. L.; Bourne, N.; Clements, D. L.; De Zotti, G.; Dunne, L.; Dye, S.; Furlanetto, C.; Ivison, R. J.; Maddox, S. J.; Valiante, E.; Baes, M.; Baker, A. J.; Cooray, A.; Crawford, S. M.; Frayer, D.; Harris, A.; Michałowski, M. J.; Nayyeri, H.; Oliver, S.; Riechers, D. A.; Serjeant, S.; Vaccari, M.

2018-04-01

With the advent of wide-area submillimetre surveys, a large number of high-redshift gravitationally lensed dusty star-forming galaxies have been revealed. Because of the simplicity of the selection criteria for candidate lensed sources in such surveys, identified as those with S500 μm > 100 mJy, uncertainties associated with the modelling of the selection function are expunged. The combination of these attributes makes submillimetre surveys ideal for the study of strong lens statistics. We carried out a pilot study of the lensing statistics of submillimetre-selected sources by making observations with the Atacama Large Millimeter Array (ALMA) of a sample of strongly lensed sources selected from surveys carried out with the Herschel Space Observatory. We attempted to reproduce the distribution of image separations for the lensed sources using a halo mass function taken from a numerical simulation that contains both dark matter and baryons. We used three different density distributions, one based on analytical fits to the haloes formed in the EAGLE simulation and two density distributions [Singular Isothermal Sphere (SIS) and SISSA] that have been used before in lensing studies. We found that we could reproduce the observed distribution with all three density distributions, as long as we imposed an upper mass transition of ˜1013 M⊙ for the SIS and SISSA models, above which we assumed that the density distribution could be represented by a Navarro-Frenk-White profile. We show that we would need a sample of ˜500 lensed sources to distinguish between the density distributions, which is practical given the predicted number of lensed sources in the Herschel surveys.

Antifouling leaching technique for optical lenses

USGS Publications Warehouse

Strahle, William J.; Perez, C. L.; Martini, Marinna A.

1994-01-01

The effectiveness of optical lenses deployed in water less than 100 m deep is significantly reduced by biofouling caused by the settlement of macrofauna, such as barnacles, hydroids, and tunicates. However, machineable porous plastic rings can be used to dispense antifoulant into the water in front of the lens to retard macrofaunal growth without obstructing the light path. Unlike coatings which can degrade the optical performance, antifouling rings do not interfere with the instrument optics. The authors have designed plastic, reusable cup-like antifouling rings to slip over the optical lenses of a transmissometer. These rings have been used for several deployments on shallow moorings in Massachusetts Bay, MA and have increased the time before fouling degrades optical characteristics

Estimating the weak-lensing rotation signal in radio cosmic shear surveys

NASA Astrophysics Data System (ADS)

Thomas, Daniel B.; Whittaker, Lee; Camera, Stefano; Brown, Michael L.

2017-09-01

Weak lensing has become an increasingly important tool in cosmology and the use of galaxy shapes to measure cosmic shear has become routine. The weak-lensing distortion tensor contains two other effects in addition to the two components of shear: the convergence and rotation. The rotation mode is not measurable using the standard cosmic shear estimators based on galaxy shapes, as there is no information on the original shapes of the images before they were lensed. Due to this, no estimator has been proposed for the rotation mode in cosmological weak-lensing surveys, and the rotation mode has never been constrained. Here, we derive an estimator for this quantity, which is based on the use of radio polarization measurements of the intrinsic position angles of galaxies. The rotation mode can be sourced by physics beyond Λ cold dark matter (ΛCDM), and also offers the chance to perform consistency checks of ΛCDM and of weak-lensing surveys themselves. We present simulations of this estimator and show that, for the pedagogical example of cosmic string spectra, this estimator could detect a signal that is consistent with the constraints from Planck. We examine the connection between the rotation mode and the shear B modes and thus how this estimator could help control systematics in future radio weak-lensing surveys.

A Laboratory Assessment of Factors That Affect Bacterial Adhesion to Contact Lenses

PubMed Central

Dutta, Debarun; Willcox, Mark DP

2013-01-01

Adhesion of pathogenic microbes, particularly bacteria, to contact lenses is implicated in contact lens related microbial adverse events. Various in vitro conditions such as type of bacteria, the size of initial inoculum, contact lens material, nutritional content of media, and incubation period can influence bacterial adhesion to contact lenses and the current study investigated the effect of these conditions on bacterial adhesion to contact lenses. There was no significant difference in numbers of bacteria that adhered to hydrogel etafilcon A or silicone hydrogel senofilcon A contact lenses. Pseudomonas aeruginosa adhered in higher numbers compared to Staphylococcus aureus. Within a genera/species, adhesion of different bacterial strains did not differ appreciably. The size of initial inoculum, nutritional content of media, and incubation period played significant roles in bacterial adhesion to lenses. A set of in vitro assay conditions to help standardize adhesion between studies have been recommended. PMID:24833224

Compact Groups analysis using weak gravitational lensing

NASA Astrophysics Data System (ADS)

Chalela, Martín; Gonzalez, Elizabeth Johana; Garcia Lambas, Diego; Foëx, Gael

2017-05-01

We present a weak lensing analysis of a sample of Sloan Digital Sky Survey compact groups (CGs). Using the measured radial density contrast profile, we derive the average masses under the assumption of spherical symmetry, obtaining a velocity dispersion for the singular isothermal spherical model, σV = 270 ± 40 km s-1, and for the NFW model, R_{200}=0.53± 0.10 h_{70}^{-1} Mpc. We test three different definitions of CG centres to identify which best traces the true dark matter halo centre, concluding that a luminosity-weighted centre is the most suitable choice. We also study the lensing signal dependence on CG physical radius, group surface brightness and morphological mixing. We find that groups with more concentrated galaxy members show steeper mass profiles and larger velocity dispersions. We argue that both, a possible lower fraction of interloper and a true steeper profile, could be playing a role in this effect. Straightforward velocity dispersion estimates from member spectroscopy yield σV ≈ 230 km s-1 in agreement with our lensing results.

Quadruple primary urogenital cancers - A case report.

PubMed

Elec, Florin-Ioan; Zaharie, Andreea; Ene, Bogdan-Mihai; Ghervan, Liviu

2017-01-01

Urogenital cancers are not an uncommon occurrence in daily practice. Prostate cancer is the second most frequent cancer in men, kidney cancer accounts for 2.4% of all cancers and bladder cancers represent 3.1% of cancers in both men and women [1]. However, the cases of a simultaneous development of all three cancers, including one with a neuroendocrine component, are very few and far between. Our case report involves a case of a patient with prostate adenocarcinoma, clear-cell renal carcinoma, papillary renal carcinoma and small-cell bladder cancer. The patient was treated as if he had separate pathologies by a multidisciplinary team: surgical and oncological, performing radical cystoprostatectomy with left perifascial nephroureterectomy, right ureterostomy and adjuvant chemotherapy, with excellent outcome even four years after the initial diagnosis. The distinct features of this case are the occurence of four different malignancies of the urogenital system, the family history of colon cancer, the development of small-cell carcinoma of the bladder, which is extremely rare and the good outcome, despite the quadruple malignancies and the aggresivity of the small-cell carcinoma. Mutiple primary malignancies are a relatively rare pathology, but should be considered as a possibility in patients who already had a second malignancy. Cases of patients with MPMs should be supervised by a multidisciplinary team and should be followed closely. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Fabrication of three-focal diffractive lenses by two-photon polymerization technique

NASA Astrophysics Data System (ADS)

Osipov, Vladimir; Doskolovich, Leonid L.; Bezus, Evgeni A.; Cheng, Wei; Gaidukeviciute, Arune; Chichkov, Boris

2012-06-01

Fabrication of submicron-height relief of three-focal diffractive lenses using two-photon polymerization is studied. Optical properties of the designed lenses are investigated theoretically and experimentally. The proposed design of the combined diffractive-refractive lenses is promising for the realization of three-focal optical ophthalmological implants with predetermined light intensity distribution between the foci. The realized three-focal optical element has a diameter size of 2.7 mm with the focal distances in the range of 27-34 mm.

Two-week, high-dose proton pump inhibitor, moxifloxacin triple Helicobacter pylori therapy after failure of standard triple or non-bismuth quadruple treatments.

PubMed

Gisbert, Javier P; Romano, Marco; Molina-Infante, Javier; Lucendo, Alfredo J; Medina, Enrique; Modolell, Inés; Rodríguez-Tellez, Manuel; Gomez, Blas; Barrio, Jesús; Perona, Monica; Ortuño, Juan; Ariño, Inés; Domínguez-Muñoz, Juan Enrique; Perez-Aisa, Ángeles; Bermejo, Fernando; Domínguez, Jose Luis; Almela, Pedro; Gomez-Camarero, Judith; Millastre, Judith; Martin-Noguerol, Elisa; Gravina, Antonietta G; Martorano, Marco; Miranda, Agnese; Federico, Alessandro; Fernandez-Bermejo, Miguel; Angueira, Teresa; Ferrer-Barcelo, Luis; Fernández, Nuria; Marín, Alicia C; McNicholl, Adrián G

2015-02-01

Aim was to evaluate the efficacy and tolerability of a moxifloxacin-containing second-line triple regimen in patients whose previous Helicobacter pylori eradication treatment failed. Prospective multicentre study including patients in whom a triple therapy or a non-bismuth-quadruple-therapy failed. Moxifloxacin (400mg qd), amoxicillin (1g bid), and esomeprazole (40 mg bid) were prescribed for 14 days. Eradication was confirmed by (13)C-urea-breath-test. Compliance was determined through questioning and recovery of empty medication envelopes. 250 patients were consecutively included (mean age 48 ± 15 years, 11% with ulcer). Previous (failed) therapy included: standard triple (n = 179), sequential (n = 27), and concomitant (n = 44); 97% of patients took all medications, 4 were lost to follow-up. Intention-to-treat and per-protocol eradication rates were 82.4% (95% CI, 77-87%) and 85.7% (95% CI, 81-90%). Cure rates were similar independently of diagnosis (ulcer, 77%; dyspepsia, 82%) and previous treatment (standard triple, 83%; sequential, 89%; concomitant, 77%). At multivariate analysis, only age was associated with eradication (OR = 0.957; 95% CI, 0.933-0.981). Adverse events were reported in 25.2% of patients: diarrhoea (9.6%), abdominal pain (9.6%), and nausea (9.2%). 14-day moxifloxacin-containing triple therapy is an effective and safe second-line strategy in patients whose previous standard triple therapy or non-bismuth quadruple (sequential or concomitant) therapy has failed, providing a simple alternative to bismuth quadruple regimen. Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Parabolic single-crystal diamond lenses for coherent x-ray imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terentyev, Sergey; Blank, Vladimir; Polyakov, Sergey

2015-09-14

We demonstrate parabolic single-crystal diamond compound refractive lenses designed for coherent x-ray imaging resilient to extreme thermal and radiation loading expected from next generation light sources. To ensure the preservation of coherence and resilience, the lenses are manufactured from the highest-quality single-crystalline synthetic diamond material grown by a high-pressure high-temperature technique. Picosecond laser milling is applied to machine lenses to parabolic with a similar or equal to 1 mu m precision and surface roughness. A compound refractive lens comprised of six lenses with a radius of curvature R = 200 mu m at the vertex of the parabola and amore » geometrical aperture A = 900 mu m focuses 10 keV x-ray photons from an undulator source at the Advanced Photon Source facility to a focal spot size of similar or equal to 20 x 90 mu m(2) with a gain factor of similar or equal to 50 - 100. (C) 2015 Author(s).« less

Parabolic single-crystal diamond lenses for coherent x-ray imaging

DOE PAGES

Terentyev, Sergey; Blank, Vladimir; Polyakov, Sergey; ...

2015-09-18

We demonstrate parabolic single-crystal diamond compound refractive lenses designed for coherent x-ray imaging resilient to extreme thermal and radiation loading expected from next generation light sources. To ensure the preservation of coherence and resilience, the lenses are manufactured from the highest-quality single-crystalline synthetic diamond material grown by a high-pressure high-temperature technique. Picosecond laser milling is applied to machine lenses to parabolic shapes with a ≃1 μm precision and surface roughness. The compound refractive lens comprised of six lenses with a radius of curvature R=200 μm at the vertex of the parabola and a geometrical aperture A=900 μm focuses 10 keVmore » x-ray photons from an undulator source at the Advanced Photon Source facility to a focal spot size of ≃20×90 μm 2 with a gain factor of ≃50-100.« less

[Some special indications for wearing contact lenses (author's transl)].

PubMed

Müller, K

1978-12-01

The typical distinguishing features of special cases which require contact lenses for satisfactory vision are described. Hence in the first case with anisometria associated with irregular astigmatism of one eye, to which a toric soft contact lens was adapted. In the second case a visual acuity of only 0,6 monocular was attained with the best spectacle lens, however with contact lense the visual acuity was 1.25. Here a verdict from a social court is mentioned, which obliged the sickness insurance to take over the costs for such a case. In the third case the adaptation of contact lenses was undertaken after radical bilateral keratoplasty because of parenchymatous keratitis, and an improvement in visual acuity of at least 400% resulted.

Amplification and polarization of supernovae by gravitational lensing

NASA Technical Reports Server (NTRS)

Schneider, P.; Wagoner, Robert V.

1987-01-01

The gravitational lensing of supernovae by individual masses which could comprise the dark matter is analyzed. Detailed predictions of the amplification and polarization are presented, including effects of a galactic environment. Their time dependence is produced by the expansion of the supernovae beam within the lens. The fraction of supernovae which might thus be identified as being lensed in surveys at proposed limiting magnitudes is estimated. These two effects could provide the only known unique signature of microlensing.

Solar concentration properties of flat fresnel lenses with large F-numbers

NASA Technical Reports Server (NTRS)

Cosby, R. M.

1978-01-01

The solar concentration performances of flat, line-focusing sun-tracking Fresnel lenses with selected f-numbers between 0.9 and 2.0 were analyzed. Lens transmittance was found to have a weak dependence on f-number, with a 2% increase occuring as the f-number is increased from 0.9 to 2.0. The geometric concentration ratio for perfectly tracking lenses peaked for an f-number near 1.35. Intensity profiles were more uniform over the image extent for large f-number lenses when compared to the f/0.9 lens results. Substantial decreases in geometri concentration ratios were observed for transverse tracking errors equal to or below 1 degree for all f-number lenses. With respect to tracking errors, the solar performance is optimum for f-numbers between 1.25 and 1.5.

Gravitational Lensing: Recent Progress & Future Goals

NASA Technical Reports Server (NTRS)

Brainerd, Tereasa

2001-01-01

This award was intended to provide financial support for an international astrophysics conference on gravitational lensing which was held at Boston University from July 25 to July 30, 1999. Because of the nature of the award, no specific research was proposed, nor was any carried out. The participants at the conference presented results of their on-going research efforts, and written summaries of their presentations have been published by the Astronomical Society of the Pacific as part of their conference series. The reference to the conference proceedings book is Gravitational Lensing: Recent Progress and Future Goals, ASP Conference Series volume 237, eds. T. G. Brainerd and C. S. Kochanek (2001). The ISBN number of this book is 1-58381-074-9. The goal of the conference was to bring together both senior and junior investigators who were actively involved in all aspects of gravitational lensing research. This was the first conference in four years to address gravitational lensing from such a broad perspective (the previous such conference being IAU Symposium 173 held in Melbourne, Australia in July 1995). The conference was attended by 190 participants, who represented of order 70 different institutions and of order 15 different countries. The Scientific Organizing Committee members were Matthias Bartelmann (co-chair), Tereasa Brainerd (co-chair), Ian Browne, Richard Ellis, Nick Kaiser, Yannick Mellier, Sjur Refsdal, HansWalter Rix, Joachim Wambsganss, and Rachel Webster. The Local Organizing Committee members were Tereasa Brainerd (chair), Emilio Falco, Jacqueline Hewitt, Christopher Kochanek, and Irwin Shapiro. The oral sessions were organized around specific applications of gravitational lensing and included invited reviews, invited 'targeted talks', and contributed talks. The review speakers were Roger Blandford, Tereasa Brainerd, Gus Evrard, Nick Kaiser, Guinevere Kaufmann, Chris Kochanek, Charley Lineweaver, Gerry Luppino, Shude Mao, Paul Schechter, Peter

Noise estimates for measurements of weak lensing from the Ly α forest

NASA Astrophysics Data System (ADS)

Metcalf, R. Benton; Croft, Rupert A. C.; Romeo, Alessandro

2018-06-01

Lensing changes the apparent separation between pixels in the Ly α forest of separate quasars or high-redshift objects by changing their observed positions on the sky. This changes the implied correlations in the absorption and in particular makes the Ly α forest correlation function, or power spectrum, locally anisotropic in the plane of the sky. We have proposed a method for measuring weak lensing using this effect. Here, we estimate the noise expected in weak lensing maps and power spectra for different sets of observational parameters. We find that surveys of the size and quality of the ones being done today and ones planned for the future will be able to measure the lensing power spectrum at a source redshift of z ≃ 2.5 with high precision and even be able to image the distribution of foreground matter with high fidelity on degree scales. For example, we predict that Ly α forest lensing measurements from the DESI and WEAVE surveys should yield the mass fluctuation amplitude with a statistical error of ˜3 per cent, eBOSS ˜6 per cent. and the proposed MSE survey less than 1 per cent. By dividing the redshift range into multiple bins, some tomographic lensing information should be accessible as well. This would allow for cosmological lensing measurements at higher redshift than are accessible with galaxy shear surveys and correspondingly better constraints on the evolution of dark energy at relatively early times.

Cosmic string lensing and closed timelike curves

NASA Astrophysics Data System (ADS)

Shlaer, Benjamin; Tye, S.-H. Henry

2005-08-01

In an analysis of the gravitational lensing by two relativistic cosmic strings, we argue that the formation of closed timelike curves proposed by Gott is unstable in the presence of particles (e.g. the cosmic microwave background radiation). Because of the attractorlike behavior of the closed timelike curve, we argue that this instability is very generic. A single graviton or photon in the vicinity, no matter how soft, is sufficient to bend the strings and prevent the formation of closed timelike curves. We also show that the gravitational lensing due to a moving cosmic string is enhanced by its motion, not suppressed.

Microlensing makes lensed quasar time delays significantly time variable

NASA Astrophysics Data System (ADS)

Tie, S. S.; Kochanek, C. S.

2018-01-01

The time delays of gravitationally lensed quasars are generally believed to be unique numbers whose measurement is limited only by the quality of the light curves and the models for the contaminating contribution of gravitational microlensing to the light curves. This belief is incorrect - gravitational microlensing also produces changes in the actual time delays on the ∼day(s) light-crossing time-scale of the emission region. This is due to a combination of the inclination of the disc relative to the line of sight and the differential magnification of the temperature fluctuations producing the variability. We demonstrate this both mathematically and with direct calculations using microlensing magnification patterns. Measuring these delay fluctuations can provide a physical scale for microlensing observations, removing the need for priors on either the microlens masses or the component velocities. That time delays in lensed quasars are themselves time variable likely explains why repeated delay measurements of individual lensed quasars appear to vary by more than their estimated uncertainties. This effect is also a new important systematic problem for attempts to use time delays in lensed quasars for cosmology or to detect substructures (satellites) in lens galaxies.

Emission-angle and polarization-rotation effects in the lensed CMB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Hall, Alex; Challinor, Anthony, E-mail: antony@cosmologist.info, E-mail: ahall@roe.ac.uk, E-mail: a.d.challinor@ast.cam.ac.uk

Lensing of the CMB is an important effect, and is usually modelled by remapping the unlensed CMB fields by a lensing deflection. However the lensing deflections also change the photon path so that the emission angle is no longer orthogonal to the background last-scattering surface. We give the first calculation of the emission-angle corrections to the standard lensing approximation from dipole (Doppler) sources for temperature and quadrupole sources for temperature and polarization. We show that while the corrections are negligible for the temperature and E-mode polarization, additional large-scale B-modes are produced with a white spectrum that dominates those from post-Bornmore » field rotation (curl lensing). On large scales about one percent of the total lensing-induced B-mode amplitude is expected to be due to this effect. However, the photon emission angle does remain orthogonal to the perturbed last-scattering surface due to time delay, and half of the large-scale emission-angle B modes cancel with B modes from time delay to give a total contribution of about half a percent. While not important for planned observations, the signal could ultimately limit the ability of delensing to reveal low amplitudes of primordial gravitational waves. We also derive the rotation of polarization due to multiple deflections between emission and observation. The rotation angle is of quadratic order in the deflection angle, and hence negligibly small: polarization typically rotates by less than an arcsecond, orders of magnitude less than a small-scale image rotates due to post-Born field rotation (which is quadratic in the shear). The field-rotation B modes dominate the other effects on small scales.« less

ICE-COLA: fast simulations for weak lensing observables

NASA Astrophysics Data System (ADS)

Izard, Albert; Fosalba, Pablo; Crocce, Martin

2018-01-01

Approximate methods to full N-body simulations provide a fast and accurate solution to the development of mock catalogues for the modelling of galaxy clustering observables. In this paper we extend ICE-COLA, based on an optimized implementation of the approximate COLA method, to produce weak lensing maps and halo catalogues in the light-cone using an integrated and self-consistent approach. We show that despite the approximate dynamics, the catalogues thus produced enable an accurate modelling of weak lensing observables one decade beyond the characteristic scale where the growth becomes non-linear. In particular, we compare ICE-COLA to the MICE Grand Challenge N-body simulation for some fiducial cases representative of upcoming surveys and find that, for sources at redshift z = 1, their convergence power spectra agree to within 1 per cent up to high multipoles (i.e. of order 1000). The corresponding shear two point functions, ξ+ and ξ-, yield similar accuracy down to 2 and 20 arcmin respectively, while tangential shear around a z = 0.5 lens sample is accurate down to 4 arcmin. We show that such accuracy is stable against an increased angular resolution of the weak lensing maps. Hence, this opens the possibility of using approximate methods for the joint modelling of galaxy clustering and weak lensing observables and their covariance in ongoing and future galaxy surveys.

Hydrogen peroxide mechanosynthesis in siloxane-hydrogel contact lenses.

PubMed

Tavazzi, Silvia; Ferraro, Lorenzo; Cozza, Federica; Pastori, Valentina; Lecchi, Marzia; Farris, Stefano; Borghesi, Alessandro

2014-11-26

Drug-loaded contact lenses are emerging as the preferred treatment method for several ocular diseases, and efforts are being directed to promote extended and controlled delivery. One strategy is based on delivery induced by environmental triggers. One of these triggers can be hydrogen peroxide, since many platforms based on drug-loaded nanoparticles were demonstrated to be hydrogen-peroxide responsive. This is particularly interesting when hydrogen peroxide is the result of a specific pathophysiological condition. Otherwise, an alternative route to induce drug delivery is here proposed, namely the mechano-synthesis. The present work represents the proof-of-concept of the mechanosynthesis of hydrogen peroxide in siloxane-hydrogel contact lenses as a consequence of the cleavage of siloxane bonds at the interface between the polymer and water in aqueous phase. Their spongy morphology makes contact lenses promising systems for mechanical-to-chemical energy conversion, since the amount of hydrogen peroxide is expected to scale with the interfacial area between the polymer and water. The eyelid pressure during wear is sufficient to induce the hydrogen peroxide synthesis with concentrations which are biocompatible and suitable to trigger the drug release through hydrogen-peroxide-responsive platforms. For possible delivery on demand, the integration of piezoelectric polymers in the siloxane-hydrogel contact lenses could be designed, whose mechanical deformation could be induced by an applied wireless-controlled voltage.

Exploring a Potential Bias in Dark Matter Investigations Using Strongly Lensed Quasars

NASA Astrophysics Data System (ADS)

Hsueh, Jen-Wei; Fassnacht, Christopher; Vegetti, Simona; Springola, Cristiana; Oldham, Lindsay; Despali, Giulia; Auger, Matthew; Xu, Dandan; Metcalf, Benton; McKean, John; Koopmans, Leon; Lagattuta, David

2018-01-01

Simulations based on ΛCDM cosmology predict thousands of substructures under galactic scale have not been detected in the local universe. One hypothesis proposes that most of these substructures are dark for various astrophysical reasons. Gravitational lensing provides a powerful alternative way to probe dark substructures in distant galaxies by detecting their gravitational perturbations and therefore provides insights into the nature of dark matter. Lensed quasars with certain image configurations are especially promising for probing substructure abundance in lens galaxy halos. When the observed flux ratios of the lensed quasar images deviate from the smooth mass model predictions, these “flux-ratio anomalies” are considered to be the evidence of gravitational perturbations. While the standard analysis of flux-ratio anomalies assumes that substructures are the only cause of anomalies, we found that in two edge-on disk lenses, B1555+375 and B0712+472, their flux anomalies can be explained by including disk components into their mass models. Our results bring up a concern with a potential bias in the previous analyses of flux-ratio anomalies. To further investigate the baryonic effects in flux-ratio anomalies, we create mock quasar lenses by selecting disk and elliptical galaxies in the Illustris simulation. Our analysis shows that baryon-induced flux anomalies can be found in all morphological types of lens galaxies. The baryonic effects increase the probability of finding lenses with strong anomalies by 8% in ellipticals and 10~20% in disk lenses, showing that the baryonic effects are unneglectable in the analysis. As future large-scale surveys are expected to bring numerous lensed quasar samples, further investigations on baryonic effects should be done in order to achieve precise constraints on dark matter in the future.

Accurate spectroscopic redshift of the multiply lensed quasar PSOJ0147 from the Pan-STARRS survey

NASA Astrophysics Data System (ADS)

Lee, C.-H.

2017-09-01

Context. The gravitational lensing time delay method provides a one-step determination of the Hubble constant (H0) with an uncertainty level on par with the cosmic distance ladder method. However, to further investigate the nature of the dark energy, a H0 estimate down to 1% level is greatly needed. This requires dozens of strongly lensed quasars that are yet to be delivered by ongoing and forthcoming all-sky surveys. Aims: In this work we aim to determine the spectroscopic redshift of PSOJ0147, the first strongly lensed quasar candidate found in the Pan-STARRS survey. The main goal of our work is to derive an accurate redshift estimate of the background quasar for cosmography. Methods: To obtain timely spectroscopically follow-up, we took advantage of the fast-track service programme that is carried out by the Nordic Optical Telescope. Using a grism covering 3200-9600 Å, we identified prominent emission line features, such as Lyα, N V, O I, C II, Si IV, C IV, and [C III] in the spectra of the background quasar of the PSOJ0147 lens system. This enables us to determine accurately the redshift of the background quasar. Results: The spectrum of the background quasar exhibits prominent absorption features bluewards of the strong emission lines, such as Lyα, N V, and C IV. These blue absorption lines indicate that the background source is a broad absorption line (BAL) quasar. Unfortunately, the BAL features hamper an accurate determination of redshift using the above-mentioned strong emission lines. Nevertheless, we are able to determine a redshift of 2.341 ± 0.001 from three of the four lensed quasar images with the clean forbidden line [C III]. In addition, we also derive a maximum outflow velocity of 9800 km s-1 with the broad absorption features bluewards of the C IV emission line. This value of maximum outflow velocity is in good agreement with other BAL quasars.

Biochemical analyses of lipids deposited on silicone hydrogel lenses

PubMed Central

Hatou, Shin; Fukui, Masaki; Yatsui, Keiichi; Mochizuki, Hiroshi; Akune, Yoko; Yamada, Masakazu

2010-01-01

Purpose This study was performed to determine the levels of lipids deposited on in vivo worn silicone hydrogel lenses. Methods Three silicone hydrogel materials, galyfilcon A, senofilcon A, and asmofilcon A, were worn for 2 weeks by 35 normal subjects. Total lipid deposition was determined by the sulfo-phospho-vanillin reaction. Cholesterol was estimated by a colorimetric probe through enzymatic oxidation. Phospholipid level was estimated by determining phosphorus with ammonium molybdate through enzymatic digestion. Results The total lipid content recovered from galyfilcon A, senofilcon A, and asmofilcon A was 32.9 ± 33.8, 42.1 ± 14.0, and 36.6 ± 31.9 μg/lens, respectively. The cholesterol content recovered from galyfilcon A, senofilcon A, and asmofilcon A was 26.2 ± 26.9, 28.6 ± 19.4, and 31.1 ± 21.1 μg/lens, respectively. There were no statistically significant differences in total lipids and cholesterol among the contact lens types. However, the quantity of phospholipid recovered from the asmofilcon A (7.0 ± 5.5 μg/lens) lenses was significantly higher than from galyfilcon A (1.1 ± 0.8 μg/lens) and senofilcon A (2.4 ± 0.8 mg/lens) lenses (p < 0.05, Mann-Whitney test). Conclusions The quantity of total lipid and cholesterol deposited on the 3 silicone hydrogel lenses tested did not differ. However, there were significant differences in the amounts of phospholipid deposited among the 3 silicone hydrogel lenses, of which clinical significance should be explored in the future study.

The effect of clulstering of galaxies on the statistics of gravitational lenses

NASA Technical Reports Server (NTRS)

Anderson, N.; Alcock, C.

1986-01-01

It is examined whether clustering of galaxies can significantly alter the statistical properties of gravitational lenses? Only models of clustering that resemble the observed distribution of galaxies in the properties of the two-point correlation function are considered. Monte-Carlo simulations of the imaging process are described. It is found that the effect of clustering is too small to be significant, unless the mass of the deflectors is so large that gravitational lenses become common occurrences. A special model is described which was concocted to optimize the effect of clustering on gravitational lensing but still resemble the observed distribution of galaxies; even this simulation did not satisfactorily produce large numbers of wide-angle lenses.

Gravitational lensing by eigenvalue distributions of random matrix models

NASA Astrophysics Data System (ADS)

Martínez Alonso, Luis; Medina, Elena

2018-05-01

We propose to use eigenvalue densities of unitary random matrix ensembles as mass distributions in gravitational lensing. The corresponding lens equations reduce to algebraic equations in the complex plane which can be treated analytically. We prove that these models can be applied to describe lensing by systems of edge-on galaxies. We illustrate our analysis with the Gaussian and the quartic unitary matrix ensembles.

Spectroscopy of Giant Arcs Behind the Strongest Lenses in the Universe

NASA Astrophysics Data System (ADS)

Hennawi, Joseph F.; Gladders, Michael; Oguri, Masamune; Koester, Benjamin; Bayliss, Matt; Dahle, Hakon; Natarajan, Priya

2009-02-01

We have conducted a deep ((mu)_g ≲ 24) imaging survey using the WIYN 4-m telescope, the UH 88-inch telescope, and the 2.5m Nordic Optical Telescope (NOT) to search for giant arcs behind the richest clusters identified in the Gpc^3 volume of the SDSS. By imaging nearly 500 massive clusters, this ongoing survey has uncovered some of the most dramatic examples of gravitational lensing ever discovered, similar to `poster-children' like Abell 1689 and CL0024+1654. We propose to use GMOS on Gemini-North and the Blue Channel Spectrograph on the MMT to determine arc redshifts in these new lenses. When combined with our GMOS data from a similar program in 2008A, this proposal will result in a sample of 60 gravitationally lensed galaxies behind ~ 25 clusters. These arc redshifts pinpoint the mass of dark matter interior to the Einstein radius in the cluster core (R < 200 kpc; comoving). The larger scale (R ~ 1-5 Mpc) weak lensing shear has been measured for more than half of our targets from deep imaging at NOT, WIYN, Subaru, and using archival data from HST. GMOS arc redshifts combined with weak and strong lensing will allow us to measure the density profile of dark matter halos on scales 200 kpc < R < 5 Mpc for the statistical sample of lensing clusters, providing a powerful test of the (Lambda)CDM paradigm.

Use of Corrective Lenses among Adolescents: Findings from the National Health and Nutrition Examination Survey