Hard and soft acids and bases: atoms and atomic ions.

PubMed

Reed, James L

2008-07-07

The structural origin of hard-soft behavior in atomic acids and bases has been explored using a simple orbital model. The Pearson principle of hard and soft acids and bases has been taken to be the defining statement about hard-soft behavior and as a definition of chemical hardness. There are a number of conditions that are imposed on any candidate structure and associated property by the Pearson principle, which have been exploited. The Pearson principle itself has been used to generate a thermodynamically based scale of relative hardness and softness for acids and bases (operational chemical hardness), and a modified Slater model has been used to discern the electronic origin of hard-soft behavior. Whereas chemical hardness is a chemical property of an acid or base and the operational chemical hardness is an experimental measure of it, the absolute hardness is a physical property of an atom or molecule. A critical examination of chemical hardness, which has been based on a more rigorous application of the Pearson principle and the availability of quantitative measures of chemical hardness, suggests that the origin of hard-soft behavior for both acids and bases resides in the relaxation of the electrons not undergoing transfer during the acid-base interaction. Furthermore, the results suggest that the absolute hardness should not be taken as synonymous with chemical hardness but that the relationship is somewhat more complex. Finally, this work provides additional groundwork for a better understanding of chemical hardness that will inform the understanding of hardness in molecules.

Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data

PubMed Central

Kümmel, Anne; Panke, Sven; Heinemann, Matthias

2006-01-01

As one of the most recent members of the omics family, large-scale quantitative metabolomics data are currently complementing our systems biology data pool and offer the chance to integrate the metabolite level into the functional analysis of cellular networks. Network-embedded thermodynamic analysis (NET analysis) is presented as a framework for mechanistic and model-based analysis of these data. By coupling the data to an operating metabolic network via the second law of thermodynamics and the metabolites' Gibbs energies of formation, NET analysis allows inferring functional principles from quantitative metabolite data; for example it identifies reactions that are subject to active allosteric or genetic regulation as exemplified with quantitative metabolite data from Escherichia coli and Saccharomyces cerevisiae. Moreover, the optimization framework of NET analysis was demonstrated to be a valuable tool to systematically investigate data sets for consistency, for the extension of sub-omic metabolome data sets and for resolving intracompartmental concentrations from cell-averaged metabolome data. Without requiring any kind of kinetic modeling, NET analysis represents a perfectly scalable and unbiased approach to uncover insights from quantitative metabolome data. PMID:16788595

ALARA at nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baum, J.W.

1990-01-01

Implementation of the As Low As Reasonably Achievable (ALARA) principle at nuclear power plants presents a continuing challenge for health physicists at utility corporate and plant levels, for plant designers, and for regulatory agencies. The relatively large collective doses at some plants are being addressed though a variety of dose reduction techniques. It is planned that this report will include material on historical aspects, management, valuation of dose reduction, quantitative and qualitative aspects of optimization, design, operational considerations, and training. The status of this work is summarized in this report. 30 refs., 1 fig., 6 tabs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turkington, T.

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

What Are We Doing When We Translate from Quantitative Models?

PubMed Central

Critchfield, Thomas S; Reed, Derek D

2009-01-01

Although quantitative analysis (in which behavior principles are defined in terms of equations) has become common in basic behavior analysis, translational efforts often examine everyday events through the lens of narrative versions of laboratory-derived principles. This approach to translation, although useful, is incomplete because equations may convey concepts that are difficult to capture in words. To support this point, we provide a nontechnical introduction to selected aspects of quantitative analysis; consider some issues that translational investigators (and, potentially, practitioners) confront when attempting to translate from quantitative models; and discuss examples of relevant translational studies. We conclude that, where behavior-science translation is concerned, the quantitative features of quantitative models cannot be ignored without sacrificing conceptual precision, scientific and practical insights, and the capacity of the basic and applied wings of behavior analysis to communicate effectively. PMID:22478533

Visual Design Principles: An Empirical Study of Design Lore

ERIC Educational Resources Information Center

Kimball, Miles A.

2013-01-01

Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

Computational modeling of brain tumors: discrete, continuum or hybrid?

NASA Astrophysics Data System (ADS)

Wang, Zhihui; Deisboeck, Thomas S.

In spite of all efforts, patients diagnosed with highly malignant brain tumors (gliomas), continue to face a grim prognosis. Achieving significant therapeutic advances will also require a more detailed quantitative understanding of the dynamic interactions among tumor cells, and between these cells and their biological microenvironment. Data-driven computational brain tumor models have the potential to provide experimental tumor biologists with such quantitative and cost-efficient tools to generate and test hypotheses on tumor progression, and to infer fundamental operating principles governing bidirectional signal propagation in multicellular cancer systems. This review highlights the modeling objectives of and challenges with developing such in silico brain tumor models by outlining two distinct computational approaches: discrete and continuum, each with representative examples. Future directions of this integrative computational neuro-oncology field, such as hybrid multiscale multiresolution modeling are discussed.

Computational modeling of brain tumors: discrete, continuum or hybrid?

NASA Astrophysics Data System (ADS)

Wang, Zhihui; Deisboeck, Thomas S.

2008-04-01

In spite of all efforts, patients diagnosed with highly malignant brain tumors (gliomas), continue to face a grim prognosis. Achieving significant therapeutic advances will also require a more detailed quantitative understanding of the dynamic interactions among tumor cells, and between these cells and their biological microenvironment. Data-driven computational brain tumor models have the potential to provide experimental tumor biologists with such quantitative and cost-efficient tools to generate and test hypotheses on tumor progression, and to infer fundamental operating principles governing bidirectional signal propagation in multicellular cancer systems. This review highlights the modeling objectives of and challenges with developing such in silicobrain tumor models by outlining two distinct computational approaches: discrete and continuum, each with representative examples. Future directions of this integrative computational neuro-oncology field, such as hybrid multiscale multiresolution modeling are discussed.

Transfer of associative grouping to novel perceptual contexts in infancy

PubMed Central

Kangas, Ashley; Zieber, Nicole; Hayden, Angela; Quinn, Paul C.; Bhatt, Ramesh S.

2012-01-01

Learning can be highly adaptive if associations learned in one context are generalized to novel contexts. We examined the development of such generalization in infancy in the context of grouping. In Experiment 1, 3- to 4-month-olds and 6- to 7-month-olds were habituated to shapes grouped via the organizational principle of common region and were tested with familiar and novel pairs as determined by the principle of proximity. Older infants generalized from common region to proximity, but younger infants did not. Younger infants failed to generalize when the task was easier (Experiment 2), and their failure was not due to inability to group via proximity (Experiment 3). However, in Experiment 4, even younger infants generalized grouping on the basis of connectedness to proximity. Thus, the ability to transfer learned associations of shapes to novel contexts is evident early in life, although it continues to undergo quantitative change during infancy. Moreover, the operation of this generalization mechanism may be induced by means of bootstrapping onto functional organizational principles, which is consistent with a developmental framework in which core processes scaffold learning. PMID:21826551

Transfer of associative grouping to novel perceptual contexts in infancy.

PubMed

Kangas, Ashley; Zieber, Nicole; Hayden, Angela; Quinn, Paul C; Bhatt, Ramesh S

2011-11-01

Learning can be highly adaptive if associations learned in one context are generalized to novel contexts. We examined the development of such generalization in infancy in the context of grouping. In Experiment 1, 3- to 4-month-olds and 6- to 7-month-olds were habituated to shapes grouped via the organizational principle of common region and were tested with familiar and novel pairs as determined by the principle of proximity. Older infants generalized from common region to proximity, but younger infants did not. Younger infants failed to generalize when the task was easier (Experiment 2), and their failure was not due to inability to group via proximity (Experiment 3). However, in Experiment 4, even younger infants generalized grouping on the basis of connectedness to proximity. Thus, the ability to transfer learned associations of shapes to novel contexts is evident early in life, although it continues to undergo quantitative change during infancy. Moreover, the operation of this generalization mechanism may be induced by means of bootstrapping onto functional organizational principles, which is consistent with a developmental framework in which core processes scaffold learning.

[Fuzzy mathematic quantitative law of composing principle in the study of traditional Chinese medicine].

PubMed

Liu, Ming; Gao, Yue; Xiao, Rui; Zhang, Bo-li

2009-01-01

This study is to analyze microcosmic significance of Chinese medicine composing principle "principal, assistant, complement and mediating guide" and it's fuzzy mathematic quantitative law. According to molecular biology and maximal membership principle, fuzzy subset and membership functions were proposed. Using in vivo experiment on the effects of SiWu Decoction and its ingredients on mice with radiation-induced blood deficiency, it is concluded that DiHuang and DangGui belonged to the principal and assistant subset, BaiShao belonged to the contrary complement subset, ChuanXiong belonged to the mediating guide subset by maximal membership principle. It is discussed that traditional Chinese medicine will be consummate medical science when its theory can be described by mathematic language.

Principles Underlying the Use of Multiple Informants’ Reports

PubMed Central

De Los Reyes, Andres; Thomas, Sarah A.; Goodman, Kimberly L.; Kundey, Shannon M.A.

2014-01-01

Researchers use multiple informants’ reports to assess and examine behavior. However, informants’ reports commonly disagree. Informants’ reports often disagree in their perceived levels of a behavior (“low” vs. “elevated” mood), and examining multiple reports in a single study often results in inconsistent findings. Although researchers often espouse taking a multi-informant assessment approach, they frequently address informant discrepancies using techniques that treat discrepancies as measurement error. Yet, recent work indicates that researchers in a variety of fields often may be unable to justify treating informant discrepancies as measurement error. In this paper, the authors advance a framework (Operations Triad Model) outlining general principles for using and interpreting informants’ reports. Using the framework, researchers can test whether or not they can extract meaningful information about behavior from discrepancies among multiple informants’ reports. The authors provide supportive evidence for this framework and discuss its implications for hypothesis testing, study design, and quantitative review. PMID:23140332

Winning Before the Fight: An Armed Suasion Approach to Countering Near Peer Competition

DTIC Science & Technology

2017-05-25

the risk of unintended escalation. This monograph also proposes a tailored set of principles , separate from the principles of joint operations...Suasion; Deterrence; Compellence; Armed Conflict; Conflict Continuum; Principles of Joint Operations. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...tailored set of principles , separate from the principles of joint operations, which allow a planning staff to balance achieving success with managing

Continuous 30-day measurements utilizing the monkey metabolism pod. [study of weightlessness effects

NASA Technical Reports Server (NTRS)

Pace, N.; Kodama, A. M.; Mains, R. C.; Rahlmann, D. F.; Grunbaum, B. W.

1977-01-01

A fiberglass system was previously described, using which quantitative physiological measurements could be made to study the effects of weightlessness on 10 to 14 kg adult monkeys maintained in comfortable restraint under space flight conditions. Recent improvements in the system have made it possible to obtain continuous measurements of respiratory gas exchange, cardiovascular function, and mineral balance for periods of up to 30 days on pig-tailed monkeys. It has also been possible to operate two pods which share one set of instrumentation, thereby permitting simultaneous measurements to be made on two animals by commutating signal outputs from the pods. In principle, more than two pods could be operated in this fashion. The system is compatible with Spacelab design. Representative physiological data from ground tests of the system are presented.

Assessing the Infusion of Sustainability Principles into University Curricula

ERIC Educational Resources Information Center

Biasutti, Michele; De Baz, Theodora; Alshawa, Hala

2016-01-01

The current paper presents the assessment of the infusion of sustainability principles into university curricula at two Jordanian universities. The peer review process of revising the curricula infusing sustainability principles is also discussed. The research methodology involved quantitative methods to assess the revised courses. The results…

General John J. Pershing: Critical Observations and Experiences in Manchuria and Mexico

DTIC Science & Technology

2017-05-25

operational art and the principles of joint operations. So while General Pershing is not largely recognized as an operational artist in contemporary...writing, his observations and experiences with regards to the elements of operational art and the principles of joint operations before World War I...Japanese War, Punitive Expedition, World War I, AEF, Operational Art, Principles of Joint Operations 16. SECURITY CLASSIFICATION OF: 17

Environment-dependent interfacial strength using first principles thermodynamics: The example of the Pt-HfO2 interface

NASA Astrophysics Data System (ADS)

Cardona Quintero, Y.; Ramanath, Ganpati; Ramprasad, R.

2013-10-01

A parameter-free, quantitative, first-principles methodology to determine the environment-dependent interfacial strength of metal-metal oxide interfaces is presented. This approach uses the notion of the weakest link to identify the most likely cleavage plane, and first principles thermodynamics to calculate the average work of separation as a function of the environment (in this case, temperature and oxygen pressure). The method is applied to the case of the Pt-HfO2 interface, and it is shown that the computed environment-dependent work of separation is in quantitative agreement with available experimental data.

Fusing Quantitative Requirements Analysis with Model-based Systems Engineering

NASA Technical Reports Server (NTRS)

Cornford, Steven L.; Feather, Martin S.; Heron, Vance A.; Jenkins, J. Steven

2006-01-01

A vision is presented for fusing quantitative requirements analysis with model-based systems engineering. This vision draws upon and combines emergent themes in the engineering milieu. "Requirements engineering" provides means to explicitly represent requirements (both functional and non-functional) as constraints and preferences on acceptable solutions, and emphasizes early-lifecycle review, analysis and verification of design and development plans. "Design by shopping" emphasizes revealing the space of options available from which to choose (without presuming that all selection criteria have previously been elicited), and provides means to make understandable the range of choices and their ramifications. "Model-based engineering" emphasizes the goal of utilizing a formal representation of all aspects of system design, from development through operations, and provides powerful tool suites that support the practical application of these principles. A first step prototype towards this vision is described, embodying the key capabilities. Illustrations, implications, further challenges and opportunities are outlined.

Demonstration of a diode-laser-based high spectral resolution lidar (HSRL) for quantitative profiling of clouds and aerosols.

PubMed

Hayman, Matthew; Spuler, Scott

2017-11-27

We present a demonstration of a diode-laser-based high spectral resolution lidar. It is capable of performing calibrated retrievals of aerosol and cloud optical properties at a 150 m range resolution with less than 1 minute integration time over an approximate range of 12 km during day and night. This instrument operates at 780 nm, a wavelength that is well established for reliable semiconductor lasers and detectors, and was chosen because it corresponds to the D2 rubidium absorption line. A heated vapor reference cell of isotopic rubidium 87 is used as an effective and reliable aerosol signal blocking filter in the instrument. In principle, the diode-laser-based high spectral resolution lidar can be made cost competitive with elastic backscatter lidar systems, yet delivers a significant improvement in data quality through direct retrieval of quantitative optical properties of clouds and aerosols.

Oxford Optronix MPM 3S: a clinical assessment of a microvascular perfusion monitor.

PubMed

Dryden, C M; Gray, W M; Asbury, A J

1992-01-01

The Oxford Optronix MPM 3S is a new microvascular perfusion monitor which is promoted as a device for use in the operating theatre. It uses a semiconductor laser diode and applies the Doppler principle to derive a semi-quantitative estimation of microvascular flow. We assessed this instrument with eight healthy volunteers who each performed eight different orthostatic arm manoeuvres while forearm skin blood flow was monitored. The different manoeuvres caused statistically significant changes in the instrument's reading which generally were consistent with expected changes in blood flow. The monitor also was assessed in the theatre environment with four anaesthetized patients. It proved easy to use, and was not subject to electrical interference from other equipment including short-wave diathermy. The major practical limitation of the technique is the semi-quantitative nature of the measurement. The instrument appears to have potential clinical uses in plastic and vascular surgery.

Generalizing Landauer's principle

NASA Astrophysics Data System (ADS)

Maroney, O. J. E.

2009-03-01

In a recent paper [Stud. Hist. Philos. Mod. Phys. 36, 355 (2005)] it is argued that to properly understand the thermodynamics of Landauer’s principle it is necessary to extend the concept of logical operations to include indeterministic operations. Here we examine the thermodynamics of such operations in more detail, extending the work of Landauer to include indeterministic operations and to include logical states with variable entropies, temperatures, and mean energies. We derive the most general statement of Landauer’s principle and prove its universality, extending considerably the validity of previous proofs. This confirms conjectures made that all logical operations may, in principle, be performed in a thermodynamically reversible fashion, although logically irreversible operations would require special, practically rather difficult, conditions to do so. We demonstrate a physical process that can perform any computation without work requirements or heat exchange with the environment. Many widespread statements of Landauer’s principle are shown to be special cases of our generalized principle.

Spatial Generalization in Operant Learning: Lessons from Professional Basketball

PubMed Central

Neiman, Tal; Loewenstein, Yonatan

2014-01-01

In operant learning, behaviors are reinforced or inhibited in response to the consequences of similar actions taken in the past. However, because in natural environments the “same” situation never recurs, it is essential for the learner to decide what “similar” is so that he can generalize from experience in one state of the world to future actions in different states of the world. The computational principles underlying this generalization are poorly understood, in particular because natural environments are typically too complex to study quantitatively. In this paper we study the principles underlying generalization in operant learning of professional basketball players. In particular, we utilize detailed information about the spatial organization of shot locations to study how players adapt their attacking strategy in real time according to recent events in the game. To quantify this learning, we study how a make \\ miss from one location in the court affects the probabilities of shooting from different locations. We show that generalization is not a spatially-local process, nor is governed by the difficulty of the shot. Rather, to a first approximation, players use a simplified binary representation of the court into 2 pt and 3 pt zones. This result indicates that rather than using low-level features, generalization is determined by high-level cognitive processes that incorporate the abstract rules of the game. PMID:24853373

Module Cluster: TTP-001.00 (GSC) Reinforcement Principles for Classroom Use.

ERIC Educational Resources Information Center

Brent, George

The purpose of this module cluster is to enable students to define the basic operant terms, to state the basic operant principles, to read operant measurement charts, and to use operant principles in elementary classrooms with both social and academic behaviors. It is intended for use by teacher education students with the cooperation of an…

MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halama, J.

2016-06-15

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

MO-AB-206-00: Nuclear Medicine Physics and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images for SPECT reconstructions. Become knowledgeable of items to be included in annual acceptance testing reports including CT dosimetry and PACS monitor measurements. T. Turkington, GE Healthcare.« less

Evaluation of an employment program for people with mental illness using the Supported Employment Fidelity Scale.

PubMed

Cocks, Errol; Boaden, Ross

2009-10-01

The Individual Placement and Support (IPS) model aims to achieve open employment for people with mental illness. The Supported Employment Fidelity Scale (SEFS) is a 15-item instrument that evaluates the extent to which a service follows the IPS principles of best practice. This paper describes the IPS model and an evaluation of a specialist employment program for people with mental illness using the SEFS. The SEFS enabled a quantitative assessment of service provision against the criteria of evidence-based practice principles. Data were collected from multiple sources. In addition, a literature review was conducted, and personnel engaged in implementation of the IPS model at other Australian employment programs were consulted. The program achieved a score of 59 of a possible 75 on the SEFS, which is described as fair supported employment. Analysis of the 15-scale items resulted in the identification of strengths, areas for further development, and a set of recommendations. The program was operating substantially in line with evidence-based practice principles and had considerable scope for further development. Issues arising from the evaluation, areas of applicability of the SEFS and the underlying literature, and implications for occupational therapy are highlighted.

Quantifying the biases in metagenome mining for realistic assessment of microbial ecology of naturally fermented foods.

PubMed

Keisam, Santosh; Romi, Wahengbam; Ahmed, Giasuddin; Jeyaram, Kumaraswamy

2016-09-27

Cultivation-independent investigation of microbial ecology is biased by the DNA extraction methods used. We aimed to quantify those biases by comparative analysis of the metagenome mined from four diverse naturally fermented foods (bamboo shoot, milk, fish, soybean) using eight different DNA extraction methods with different cell lysis principles. Our findings revealed that the enzymatic lysis yielded higher eubacterial and yeast metagenomic DNA from the food matrices compared to the widely used chemical and mechanical lysis principles. Further analysis of the bacterial community structure by Illumina MiSeq amplicon sequencing revealed a high recovery of lactic acid bacteria by the enzymatic lysis in all food types. However, Bacillaceae, Acetobacteraceae, Clostridiaceae and Proteobacteria were more abundantly recovered when mechanical and chemical lysis principles were applied. The biases generated due to the differential recovery of operational taxonomic units (OTUs) by different DNA extraction methods including DNA and PCR amplicons mix from different methods have been quantitatively demonstrated here. The different methods shared only 29.9-52.0% of the total OTUs recovered. Although similar comparative research has been performed on other ecological niches, this is the first in-depth investigation of quantifying the biases in metagenome mining from naturally fermented foods.

Resource Theory of Superposition

NASA Astrophysics Data System (ADS)

Theurer, T.; Killoran, N.; Egloff, D.; Plenio, M. B.

2017-12-01

The superposition principle lies at the heart of many nonclassical properties of quantum mechanics. Motivated by this, we introduce a rigorous resource theory framework for the quantification of superposition of a finite number of linear independent states. This theory is a generalization of resource theories of coherence. We determine the general structure of operations which do not create superposition, find a fundamental connection to unambiguous state discrimination, and propose several quantitative superposition measures. Using this theory, we show that trace decreasing operations can be completed for free which, when specialized to the theory of coherence, resolves an outstanding open question and is used to address the free probabilistic transformation between pure states. Finally, we prove that linearly independent superposition is a necessary and sufficient condition for the faithful creation of entanglement in discrete settings, establishing a strong structural connection between our theory of superposition and entanglement theory.

A perspective on bridging scales and design of models using low-dimensional manifolds and data-driven model inference

PubMed Central

Zenil, Hector; Kiani, Narsis A.; Ball, Gordon; Gomez-Cabrero, David

2016-01-01

Systems in nature capable of collective behaviour are nonlinear, operating across several scales. Yet our ability to account for their collective dynamics differs in physics, chemistry and biology. Here, we briefly review the similarities and differences between mathematical modelling of adaptive living systems versus physico-chemical systems. We find that physics-based chemistry modelling and computational neuroscience have a shared interest in developing techniques for model reductions aiming at the identification of a reduced subsystem or slow manifold, capturing the effective dynamics. By contrast, as relations and kinetics between biological molecules are less characterized, current quantitative analysis under the umbrella of bioinformatics focuses on signal extraction, correlation, regression and machine-learning analysis. We argue that model reduction analysis and the ensuing identification of manifolds bridges physics and biology. Furthermore, modelling living systems presents deep challenges as how to reconcile rich molecular data with inherent modelling uncertainties (formalism, variables selection and model parameters). We anticipate a new generative data-driven modelling paradigm constrained by identified governing principles extracted from low-dimensional manifold analysis. The rise of a new generation of models will ultimately connect biology to quantitative mechanistic descriptions, thereby setting the stage for investigating the character of the model language and principles driving living systems. This article is part of the themed issue ‘Multiscale modelling at the physics–chemistry–biology interface’. PMID:27698038

Principles of a clean operating room environment.

PubMed

Howard, James L; Hanssen, Arlen D

2007-10-01

Optimizing the operating room environment is necessary to minimize the prevalence of arthroplasty infection. Reduction of bacterial contamination in the operating room should be a primary focus of all members of the operating room team. However, in recent years, there has been a decline in the emphasis of the basic principles of antisepsis in many operating rooms. The purpose of this review is to highlight important considerations for optimizing the operating room environment. These principles should be actively promoted by orthopedic surgeons in their operating rooms as part of a comprehensive approach to minimizing arthroplasty infection.

Autonomous quantum Maxwell's demon based on two exchange-coupled quantum dots

NASA Astrophysics Data System (ADS)

Ptaszyński, Krzysztof

2018-01-01

I study an autonomous quantum Maxwell's demon based on two exchange-coupled quantum dots attached to the spin-polarized leads. The principle of operation of the demon is based on the coherent oscillations between the spin states of the system which act as a quantum iSWAP gate. Due to the operation of the iSWAP gate, one of the dots acts as a feedback controller which blocks the transport with the bias in the other dot, thus inducing the electron pumping against the bias; this leads to the locally negative entropy production. Operation of the demon is associated with the information transfer between the dots, which is studied quantitatively by mapping the analyzed setup onto the thermodynamically equivalent auxiliary system. The calculated entropy production in a single subsystem and information flow between the subsystems are shown to obey a local form of the second law of thermodynamics, similar to the one previously derived for classical bipartite systems.

Effect of Scaffolding on Helping Introductory Physics Students Solve Quantitative Problems Involving Strong Alternative Conceptions

ERIC Educational Resources Information Center

Lin, Shih-Yin; Singh, Chandralekha

2015-01-01

It is well known that introductory physics students often have alternative conceptions that are inconsistent with established physical principles and concepts. Invoking alternative conceptions in the quantitative problem-solving process can derail the entire process. In order to help students solve quantitative problems involving strong…

Modeling the Effect of Polychromatic Light in Quantitative Absorbance Spectroscopy

ERIC Educational Resources Information Center

Smith, Rachel; Cantrell, Kevin

2007-01-01

Laboratory experiment is conducted to give the students practical experience with the principles of electronic absorbance spectroscopy. This straightforward approach creates a powerful tool for exploring many of the aspects of quantitative absorbance spectroscopy.

Quantitative Boltzmann-Gibbs Principles via Orthogonal Polynomial Duality

NASA Astrophysics Data System (ADS)

Ayala, Mario; Carinci, Gioia; Redig, Frank

2018-06-01

We study fluctuation fields of orthogonal polynomials in the context of particle systems with duality. We thereby obtain a systematic orthogonal decomposition of the fluctuation fields of local functions, where the order of every term can be quantified. This implies a quantitative generalization of the Boltzmann-Gibbs principle. In the context of independent random walkers, we complete this program, including also fluctuation fields in non-stationary context (local equilibrium). For other interacting particle systems with duality such as the symmetric exclusion process, similar results can be obtained, under precise conditions on the n particle dynamics.

Ultrathin conformal devices for precise and continuous thermal characterization of human skin

PubMed Central

Webb, R. Chad; Bonifas, Andrew P.; Behnaz, Alex; Zhang, Yihui; Yu, Ki Jun; Cheng, Huanyu; Shi, Mingxing; Bian, Zuguang; Liu, Zhuangjian; Kim, Yun-Soung; Yeo, Woon-Hong; Park, Jae Suk; Song, Jizhou; Li, Yuhang; Huang, Yonggang; Gorbach, Alexander M.; Rogers, John A.

2013-01-01

Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples. PMID:24037122

Ultrathin conformal devices for precise and continuous thermal characterization of human skin

NASA Astrophysics Data System (ADS)

Webb, R. Chad; Bonifas, Andrew P.; Behnaz, Alex; Zhang, Yihui; Yu, Ki Jun; Cheng, Huanyu; Shi, Mingxing; Bian, Zuguang; Liu, Zhuangjian; Kim, Yun-Soung; Yeo, Woon-Hong; Park, Jae Suk; Song, Jizhou; Li, Yuhang; Huang, Yonggang; Gorbach, Alexander M.; Rogers, John A.

2013-10-01

Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.

Measuring coherence with entanglement concurrence

NASA Astrophysics Data System (ADS)

Qi, Xianfei; Gao, Ting; Yan, Fengli

2017-07-01

Quantum coherence is a fundamental manifestation of the quantum superposition principle. Recently, Baumgratz et al (2014 Phys. Rev. Lett. 113 140401) presented a rigorous framework to quantify coherence from the view of theory of physical resource. Here we propose a new valid quantum coherence measure which is a convex roof measure, for a quantum system of arbitrary dimension, essentially using the generalized Gell-Mann matrices. Rigorous proof shows that the proposed coherence measure, coherence concurrence, fulfills all the requirements dictated by the resource theory of quantum coherence measures. Moreover, strong links between the resource frameworks of coherence concurrence and entanglement concurrence is derived, which shows that any degree of coherence with respect to some reference basis can be converted to entanglement via incoherent operations. Our work provides a clear quantitative and operational connection between coherence and entanglement based on two kinds of concurrence. This new coherence measure, coherence concurrence, may also be beneficial to the study of quantum coherence.

An airborne compatible photofragmentation two-photon laser-induced fluorescence instrument for measuring background tropospheric levels of NO, NO(x), and NO2

NASA Technical Reports Server (NTRS)

Sandholm, S. T.; Bradshaw, J. D.; Dorris, K. S.; Rodgers, M. O.; Davis, D. D.

1990-01-01

The operating principle, design, and performance of a two-photon LIF (TP-LIF) sensor for simultaneous measurements of NO, NO(x) (NO + NO2), and NO2 are described. In this instrument, NO is first measured by direct spectroscopic TP-LIF detection; NO2 is converted to NO by photofragmentation using an XeF excimer laser operating at 353 nm; and the resulting NO is then detected quantitatively by TP-LIF. The detection limits of the instrument are found to be 3.5 parts per trillion by volume (pptv) of NO and 10 pptv for NO2, with integration times of 2 and 6 min, respectively. The in-flight performance of the instrument was evaluated during the NASA Global Tropospheric Experiment Chemical Instrumentation Test and Evaluation 2 program in summer 1986, as reported by Gregory et al. (1990).

Quantitative experimental assessment of hot carrier-enhanced solar cells at room temperature

NASA Astrophysics Data System (ADS)

Nguyen, Dac-Trung; Lombez, Laurent; Gibelli, François; Boyer-Richard, Soline; Le Corre, Alain; Durand, Olivier; Guillemoles, Jean-François

2018-03-01

In common photovoltaic devices, the part of the incident energy above the absorption threshold quickly ends up as heat, which limits their maximum achievable efficiency to far below the thermodynamic limit for solar energy conversion. Conversely, the conversion of the excess kinetic energy of the photogenerated carriers into additional free energy would be sufficient to approach the thermodynamic limit. This is the principle of hot carrier devices. Unfortunately, such device operation in conditions relevant for utilization has never been evidenced. Here, we show that the quantitative thermodynamic study of the hot carrier population, with luminance measurements, allows us to discuss the hot carrier contribution to the solar cell performance. We demonstrate that the voltage and current can be enhanced in a semiconductor heterostructure due to the presence of the hot carrier population in a single InGaAsP quantum well at room temperature. These experimental results substantiate the potential of increasing photovoltaic performances in the hot carrier regime.

Chemically-inducible diffusion trap at cilia (C-IDTc) reveals molecular sieve-like barrier

PubMed Central

Lin, Yu-Chun; Phua, Siew Cheng; Jiao, John; Levchenko, Andre; Inoue, Takafumi; Rohatgi, Rajat; Inoue, Takanari

2013-01-01

Primary cilia function as specialized compartments for signal transduction. The stereotyped structure and signaling function of cilia inextricably depend on the selective segregation of molecules in cilia. However, the fundamental principles governing the access of soluble proteins to primary cilia remain unresolved. We developed a methodology termed Chemically-Inducible Diffusion Trap at Cilia (C-IDTc) to visualize the diffusion process of a series of fluorescent proteins ranging in size from 3.2 to 7.9 nm into primary cilia. We found that the interior of the cilium was accessible to proteins as large as 7.9 nm. The kinetics of ciliary accumulation of this panel of proteins was exponentially limited by their Stokes radii. Quantitative modeling suggests that the diffusion barrier operates as a molecular sieve at the base of cilia. Our study presents a set of powerful, generally applicable tools for the quantitative monitoring of ciliary protein diffusion under both physiological and pathological conditions. PMID:23666116

Creating Feedback Channels With Optical Communications For Information Operations (IO)

DTIC Science & Technology

2016-06-01

amphibious operations. Optical communications technologies, direct marketing principles , and current IO shortfalls are explored to determine whether...technology. First, these concepts are applied to show covert amphibious operations. Optical communications technologies, direct marketing principles , and...power, as per Appendix A. A major portion of the marketing campaign comes in the form of advertising. The correlating principles of advertising in

Teaching customer-centric operations management - evidence from an experiential learning-oriented mass customisation class

NASA Astrophysics Data System (ADS)

Medini, Khaled

2018-01-01

The increase of individualised customer demands and tough competition in the manufacturing sector gave rise to more customer-centric operations management such as products and services (mass) customisation. Mass customisation (MC), which inherits the 'economy of scale' from mass production (MP), aims to meet specific customer demands with near MP efficiency. Such an overarching concept has multiple impacts on operations management. This requires highly qualified and multi-skilled engineers who are well prepared for managing MC. Therefore, this concept should be properly addressed by engineering education curricula which needs to keep up with the emerging business trends. This paper introduces a novel course about MC and variety in operations management which recalls several Experiential Learning (EL) practices consistently with the principle of an active learning. The paper aims to analyse to which extent EL can improve the efficiency of the teaching methods and the retention rate in the context of operations management. The proposed course is given to engineering students whose' perceptions are collected using semi-structured questionnaires and analysed quantitatively and qualitatively. The paper highlights the relevance (i) of teaching MC, and (ii) of active learning in engineering education, through the specific application in the domain of MC.

Operational seasonal forecasting of crop performance.

PubMed

Stone, Roger C; Meinke, Holger

2005-11-29

Integrated, interdisciplinary crop performance forecasting systems, linked with appropriate decision and discussion support tools, could substantially improve operational decision making in agricultural management. Recent developments in connecting numerical weather prediction models and general circulation models with quantitative crop growth models offer the potential for development of integrated systems that incorporate components of long-term climate change. However, operational seasonal forecasting systems have little or no value unless they are able to change key management decisions. Changed decision making through incorporation of seasonal forecasting ultimately has to demonstrate improved long-term performance of the cropping enterprise. Simulation analyses conducted on specific production scenarios are especially useful in improving decisions, particularly if this is done in conjunction with development of decision-support systems and associated facilitated discussion groups. Improved management of the overall crop production system requires an interdisciplinary approach, where climate scientists, agricultural scientists and extension specialists are intimately linked with crop production managers in the development of targeted seasonal forecast systems. The same principle applies in developing improved operational management systems for commodity trading organizations, milling companies and agricultural marketing organizations. Application of seasonal forecast systems across the whole value chain in agricultural production offers considerable benefits in improving overall operational management of agricultural production.

Operational seasonal forecasting of crop performance

PubMed Central

Stone, Roger C; Meinke, Holger

2005-01-01

Integrated, interdisciplinary crop performance forecasting systems, linked with appropriate decision and discussion support tools, could substantially improve operational decision making in agricultural management. Recent developments in connecting numerical weather prediction models and general circulation models with quantitative crop growth models offer the potential for development of integrated systems that incorporate components of long-term climate change. However, operational seasonal forecasting systems have little or no value unless they are able to change key management decisions. Changed decision making through incorporation of seasonal forecasting ultimately has to demonstrate improved long-term performance of the cropping enterprise. Simulation analyses conducted on specific production scenarios are especially useful in improving decisions, particularly if this is done in conjunction with development of decision-support systems and associated facilitated discussion groups. Improved management of the overall crop production system requires an interdisciplinary approach, where climate scientists, agricultural scientists and extension specialists are intimately linked with crop production managers in the development of targeted seasonal forecast systems. The same principle applies in developing improved operational management systems for commodity trading organizations, milling companies and agricultural marketing organizations. Application of seasonal forecast systems across the whole value chain in agricultural production offers considerable benefits in improving overall operational management of agricultural production. PMID:16433097

Application of First Principles Ni-Cd and Ni-H2 Battery Models to Spacecraft Operations

NASA Technical Reports Server (NTRS)

Timmerman, Paul; Bugga, Ratnakumar; DiStefano, Salvador

1997-01-01

The conclusions of the application of first principles model to spacecraft operations are: the first principles of Bi-phasic electrode presented model provides an explanation for many behaviors on voltage fading on LEO cycling.

Early Oscillation Detection for Hybrid DC/DC Converter Fault Diagnosis

NASA Technical Reports Server (NTRS)

Wang, Bright L.

2011-01-01

This paper describes a novel fault detection technique for hybrid DC/DC converter oscillation diagnosis. The technique is based on principles of feedback control loop oscillation and RF signal modulations, and Is realized by using signal spectral analysis. Real-circuit simulation and analytical study reveal critical factors of the oscillation and indicate significant correlations between the spectral analysis method and the gain/phase margin method. A stability diagnosis index (SDI) is developed as a quantitative measure to accurately assign a degree of stability to the DC/DC converter. This technique Is capable of detecting oscillation at an early stage without interfering with DC/DC converter's normal operation and without limitations of probing to the converter.

Humidity measurements in passive heat and moisture exchangers applications: a critical issue.

PubMed

Dubini, G; Fumero, R

2000-01-01

A reliable, quantitative assessment of humidification performances of passive heat and moisture exchangers in mechanically-ventilated patients is still to be achieved, although relevant efforts have been made to date. One of the major problems to tackle consists in the difficulty of humidity measurements, both in vivo (during either anaesthesia or intensive care unit treatments) and in vitro set-ups. In this paper a review of the basic operation principles of humidity sensors as well as an analysis of their usage within in vivo and in vitro tests are presented. Particular attention is devoted to the limitations arising from the specific measurement set-up, as they may affect the results notably.

[Evaluation on methodological problems in reports concerning quantitative analysis of syndrome differentiation of diabetes mellitus].

PubMed

Chen, Bi-Cang; Wu, Qiu-Ying; Xiang, Cheng-Bin; Zhou, Yi; Guo, Ling-Xiang; Zhao, Neng-Jiang; Yang, Shu-Yu

2006-01-01

To evaluate the quality of reports published in recent 10 years in China about quantitative analysis of syndrome differentiation for diabetes mellitus (DM) in order to explore the methodological problems in these reports and find possible solutions. The main medical literature databases in China were searched. Thirty-one articles were included and evaluated by the principles of clinical epidemiology. There were many mistakes and deficiencies in these articles, such as clinical trial designs, diagnosis criteria for DM, standards of syndrome differentiation of DM, case inclusive and exclusive criteria, sample size and estimation, data comparability and statistical methods. It is necessary and important to improve the quality of reports concerning quantitative analysis of syndrome differentiation of DM in light of the principles of clinical epidemiology.

Computations in the deep vs superficial layers of the cerebral cortex.

PubMed

Rolls, Edmund T; Mills, W Patrick C

2017-11-01

A fundamental question is how the cerebral neocortex operates functionally, computationally. The cerebral neocortex with its superficial and deep layers and highly developed recurrent collateral systems that provide a basis for memory-related processing might perform somewhat different computations in the superficial and deep layers. Here we take into account the quantitative connectivity within and between laminae. Using integrate-and-fire neuronal network simulations that incorporate this connectivity, we first show that attractor networks implemented in the deep layers that are activated by the superficial layers could be partly independent in that the deep layers might have a different time course, which might because of adaptation be more transient and useful for outputs from the neocortex. In contrast the superficial layers could implement more prolonged firing, useful for slow learning and for short-term memory. Second, we show that a different type of computation could in principle be performed in the superficial and deep layers, by showing that the superficial layers could operate as a discrete attractor network useful for categorisation and feeding information forward up a cortical hierarchy, whereas the deep layers could operate as a continuous attractor network useful for providing a spatially and temporally smooth output to output systems in the brain. A key advance is that we draw attention to the functions of the recurrent collateral connections between cortical pyramidal cells, often omitted in canonical models of the neocortex, and address principles of operation of the neocortex by which the superficial and deep layers might be specialized for different types of attractor-related memory functions implemented by the recurrent collaterals. Copyright © 2017 Elsevier Inc. All rights reserved.

Spaceborne receivers: Basic principles

NASA Technical Reports Server (NTRS)

Stacey, J. M.

1984-01-01

The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.

77 FR 8879 - Agency Information Collection Activities; Proposed Collection; Comment Request: Guidance for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Separator Device Operating by Centrifugal or Filtration Separation Principle AGENCY: Food and Drug... automated blood cell separator device operating by centrifugal or filtration separation principle. DATES... Filtration Separation Principle (OMB Control Number 0910-0594)--Extension Under the Safe Medical Devices Act...

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

PubMed Central

2013-01-01

Background Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Methods Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). Results The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. Conclusions We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials. PMID:23433341

Borehole geophysics applied to ground-water investigations

USGS Publications Warehouse

Keys, W.S.

1990-01-01

The purpose of this manual is to provide hydrologists, geologists, and others who have the necessary background in hydrogeology with the basic information needed to apply the most useful borehole-geophysical-logging techniques to the solution of problems in ground-water hydrology. Geophysical logs can provide information on the construction of wells and on the character of the rocks and fluids penetrated by those wells, as well as on changes in the character of these factors over time. The response of well logs is caused by petrophysical factors, by the quality, temperature, and pressure of interstitial fluids, and by ground-water flow. Qualitative and quantitative analysis of analog records and computer analysis of digitized logs are used to derive geohydrologic information. This information can then be extrapolated vertically within a well and laterally to other wells using logs. The physical principles by which the mechanical and electronic components of a logging system measure properties of rocks, fluids, and wells, as well as the principles of measurement, must be understood if geophysical logs are to be interpreted correctly. Plating a logging operation involves selecting the equipment and the logs most likely to provide the needed information. Information on well construction and geohydrology is needed to guide this selection. Quality control of logs is an important responsibility of both the equipment operator and the log analyst and requires both calibration and well-site standardization of equipment. Logging techniques that are widely used in ground-water hydrology or that have significant potential for application to this field include spontaneous potential, resistance, resistivity, gamma, gamma spectrometry, gamma-gamma, neutron, acoustic velocity, acoustic televiewer, caliper, and fluid temperature, conductivity, and flow. The following topics are discussed for each of these techniques: principles and instrumentation, calibration and standardization, volume of investigation, extraneous effects, and interpretation and applications.

Borehole geophysics applied to ground-water investigations

USGS Publications Warehouse

Keys, W.S.

1988-01-01

The purpose of this manual is to provide hydrologists, geologists, and others who have the necessary training with the basic information needed to apply the most useful borehole-geophysical-logging techniques to the solution of problems in ground-water hydrology. Geophysical logs can provide information on the construction of wells and on the character of the rocks and fluids penetrated by those wells, in addition to changes in the character of these factors with time. The response of well logs is caused by: petrophysical factors; the quality; temperature, and pressure of interstitial fluids; and ground-water flow. Qualitative and quantitative analysis of the analog records and computer analysis of digitized logs are used to derive geohydrologic information. This information can then be extrapolated vertically within a well and laterally to other wells using logs.The physical principles by which the mechanical and electronic components of a logging system measure properties of rocks, fluids and wells, and the principles of measurement need to be understood to correctly interpret geophysical logs. Planning the logging operation involves selecting the equipment and the logs most likely to provide the needed information. Information on well construction and geohydrology are needed to guide this selection. Quality control of logs is an important responsibility of both the equipment operator and log analyst and requires both calibration and well-site standardization of equipment.Logging techniques that are widely used in ground-water hydrology or that have significant potential for application to this field include: spontaneous potential, resistance, resistivity, gamma, gamma spectrometry, gamma-gamma, neutron, acoustic velocity, acoustic televiewer, caliper, and fluid temperature, conductivity, and flow. The following topics are discussed for each of these techniques: principles and instrumentation, calibration and standardization, volume of investigation, extraneous effects, and interpretation and applications.

Some special features of the le chatelier-braun principle

NASA Astrophysics Data System (ADS)

Nesis, E. I.; Skibin, Yu. N.

2000-07-01

The relaxation reaction of a system that follows from the Le Chatelier-Braun principle and weakens the result of an external influence turns out to be more intense under a complex action. A method for quantitative determination of the weakening effect for simple and complex actions is suggested.

Role of Service Learning in Water Quality Studies

ERIC Educational Resources Information Center

Richards, Wilfred Sugumar

2009-01-01

Background: Chemistry students often complain that they are unmotivated because they see no applications of chemical principles in "real life." It was thus decided to put into use the knowledge gained during the course on water quality and analysis. Learning the principles of quantitative chemical analysis requires innovative, hands-on…

The Application of Tissue Engineering Procedures to Repair the Larynx

ERIC Educational Resources Information Center

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

The Impact on Student Achievement Following Professional Development on the Principles of Formative Assessment

ERIC Educational Resources Information Center

DeNome, Evonne C.

2015-01-01

This quantitative study reviews the impact on student achievement following professional development on the principles of formative assessment. The study compared mathematics and reading performance data from student populations with teachers who received training in formative assessment to performance data from student populations with teachers…

28 CFR 23.20 - Operating principles.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL INTELLIGENCE SYSTEMS OPERATING POLICIES § 23.20 Operating principles. (a) A project shall collect and maintain criminal intelligence information concerning... shall not collect or maintain criminal intelligence information about the political, religious or social...

28 CFR 23.20 - Operating principles.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL INTELLIGENCE SYSTEMS OPERATING POLICIES § 23.20 Operating principles. (a) A project shall collect and maintain criminal intelligence information concerning... shall not collect or maintain criminal intelligence information about the political, religious or social...

28 CFR 23.20 - Operating principles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL INTELLIGENCE SYSTEMS OPERATING POLICIES § 23.20 Operating principles. (a) A project shall collect and maintain criminal intelligence information concerning... shall not collect or maintain criminal intelligence information about the political, religious or social...

28 CFR 23.20 - Operating principles.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL INTELLIGENCE SYSTEMS OPERATING POLICIES § 23.20 Operating principles. (a) A project shall collect and maintain criminal intelligence information concerning... shall not collect or maintain criminal intelligence information about the political, religious or social...

28 CFR 23.20 - Operating principles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL INTELLIGENCE SYSTEMS OPERATING POLICIES § 23.20 Operating principles. (a) A project shall collect and maintain criminal intelligence information concerning... shall not collect or maintain criminal intelligence information about the political, religious or social...

12 CFR 223.21 - What valuation and timing principles apply to credit transactions?

Code of Federal Regulations, 2011 CFR

2011-01-01

... compliance with the quantitative limits of §§ 223.11 and 223.12 in connection with any future covered... nonaffiliate) would not exceed the quantitative limits of § 223.11 or 223.12 at the time the nonaffiliate... the quantitative limits of § 223.11 or 223.12 at the time of the stock acquisition. The member bank is...

Extrapolation, uncertainty factors, and the precautionary principle.

PubMed

Steel, Daniel

2011-09-01

This essay examines the relationship between the precautionary principle and uncertainty factors used by toxicologists to estimate acceptable exposure levels for toxic chemicals from animal experiments. It shows that the adoption of uncertainty factors in the United States in the 1950s can be understood by reference to the precautionary principle, but not by cost-benefit analysis because of a lack of relevant quantitative data at that time. In addition, it argues that uncertainty factors continue to be relevant to efforts to implement the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards. Copyright © 2011 Elsevier Ltd. All rights reserved.

Principles for timing at spallation neutron sources based on developments at LANSCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, R. O.; Merl, R. B.; Rose, C. R.

2001-01-01

Due to AC-power-grid frequency fluctuations, the designers for accelerator-based spallation-neutron facilities have worked to optimize the conflicting demands of accelerator and neutron chopper performance. For the first time, we are able to quantitatively access the tradeoffs between these two constraints and design or upgrade a facility to optimize total system performance using powerful new simulation techniques. We have modeled timing systems that integrate chopper controllers and chopper hardware and built new systems. Thus, at LANSCE, we now operate multiple chopper systems and the accelerator as simple slaves to a single master-timing-reference generator. Based on this experience we recommend that spallationmore » neutron sources adhere to three principles. First, timing for pulsed sources should be planned starting with extraction at a fixed phase and working backwards toward the leading edge of the beam pulse. Second, accelerator triggers and storage ring extraction commands from neutron choppers offer only marginal benefits to accelerator-based spallation sources. Third, the storage-ring RF should be phase synchronized with neutron choppers to provide extraction without the one orbit timing uncertainty.« less

Finding the Secret of Image Saliency in the Frequency Domain.

PubMed

Li, Jia; Duan, Ling-Yu; Chen, Xiaowu; Huang, Tiejun; Tian, Yonghong

2015-12-01

There are two sides to every story of visual saliency modeling in the frequency domain. On the one hand, image saliency can be effectively estimated by applying simple operations to the frequency spectrum. On the other hand, it is still unclear which part of the frequency spectrum contributes the most to popping-out targets and suppressing distractors. Toward this end, this paper tentatively explores the secret of image saliency in the frequency domain. From the results obtained in several qualitative and quantitative experiments, we find that the secret of visual saliency may mainly hide in the phases of intermediate frequencies. To explain this finding, we reinterpret the concept of discrete Fourier transform from the perspective of template-based contrast computation and thus develop several principles for designing the saliency detector in the frequency domain. Following these principles, we propose a novel approach to design the saliency detector under the assistance of prior knowledge obtained through both unsupervised and supervised learning processes. Experimental results on a public image benchmark show that the learned saliency detector outperforms 18 state-of-the-art approaches in predicting human fixations.

Temporal maps and informativeness in associative learning.

PubMed

Balsam, Peter D; Gallistel, C Randy

2009-02-01

Neurobiological research on learning assumes that temporal contiguity is essential for association formation, but what constitutes temporal contiguity has never been specified. We review evidence that learning depends, instead, on learning a temporal map. Temporal relations between events are encoded even from single experiences. The speed with which an anticipatory response emerges is proportional to the informativeness of the encoded relation between a predictive stimulus or event and the event it predicts. This principle yields a quantitative account of the heretofore undefined, but theoretically crucial, concept of temporal pairing, an account in quantitative accord with surprising experimental findings. The same principle explains the basic results in the cue competition literature, which motivated the Rescorla-Wagner model and most other contemporary models of associative learning. The essential feature of a memory mechanism in this account is its ability to encode quantitative information.

Temporal maps and informativeness in associative learning

PubMed Central

Balsam, Peter D; Gallistel, C. Randy

2009-01-01

Neurobiological research on learning assumes that temporal contiguity is essential for association formation, but what constitutes temporal contiguity has never been specified. We review evidence that learning depends, instead, on learning a temporal map. Temporal relations between events are encoded even from single experiences. The speed with which an anticipatory response emerges is proportional to the informativeness of the encoded relation between a predictive stimulus or event and the event it predicts. This principle yields a quantitative account of the heretofore undefined, but theoretically crucial, concept of temporal pairing, an account in quantitative accord with surprising experimental findings. The same principle explains the basic results in the cue competition literature, which motivated the Rescorla–Wagner model and most other contemporary models of associative learning. The essential feature of a memory mechanism in this account is its ability to encode quantitative information. PMID:19136158

Toward characterization of Huber's ball-bearing motor

NASA Astrophysics Data System (ADS)

Choo, Joo Liang; Soong, Wen Liang; Abbott, Derek

2005-02-01

A motor that can be powered up by either a DC or AC supply and rotates in either direction, based on the so-called Huber effect, is investigated. For the first time, this paper examines the motor characteristics under both DC and AC conditions, for quantitative comparisons. Earlier work has not examined, in detail, the effect of an AC supply on the Huber motor operation. Previous work on the Huber or ball-bearing motor suffered from alignment problems and here we describe a new methodology to address this. The new construction is also a step toward a micromotor realization. The motor, with its reduced dimensions, also has the advantage of reduced operating current. Since 1959, the principle of operation of this motor has remained an unsolved mystery and various theories exist in the literature. We show various empirical findings that shed some light on the hotly contested debate. The discovery of carbon on the bearings, under AC supply conditions, reported here creates a new open question. Motor acceleration versus torque characteristics are obtained, using a data acquisition system to facilitate dynamic real-time recording.

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XVI, LEARNING ABOUT AC GENERATOR (ALTERNATOR) PRINCIPLES (PART I).

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES OF ALTERNATING CURRENT GENERATORS USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE REVIEWING ELECTRICAL FUNDAMENTALS, AND OPERATING PRINCIPLES OF ALTERNATORS. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL PROGRAMED TRAINING FILM "AC GENERATORS…

Isomer-Specific Hydrogen Bonding as a Design Principle for Bidirectionally Quantitative and Redshifted Hemithioindigo Photoswitches.

PubMed

Zweig, Joshua E; Newhouse, Timothy R

2017-08-16

A new class of bidirectionally quantitative photoswitches based on the hemithioindigo (HTI) scaffold is reported. Incorporation of a pyrrole hydrogen-bond donor leads to a bathochromic shift allowing for quantitative bidirectional isomerization. Additionally, extending conjugation from the electron-rich pyrrole results in quantitative visible-light photoswitches, as well as photoswitches that isomerize with red and near-infrared light. The presence of the hydrogen bond leading to the observed redshift is supported by computational and spectroscopic evidence.

Endoscopic low coherence interferometry in upper airways

NASA Astrophysics Data System (ADS)

Delacrétaz, Yves; Boss, Daniel; Lang, Florian; Depeursinge, Christian

2009-07-01

We introduce Endoscopic Low Coherence Interferometry to obtain topology of upper airways through commonly used rigid endoscopes. Quantitative dimensioning of upper airways pathologies is crucial to provide maximum health recovery chances, for example in order to choose the correct stent to treat endoluminal obstructing pathologies. Our device is fully compatible with procedures used in day-to-day examinations and can potentially be brought to bedside. Besides this, the approach described here can be almost straightforwardly adapted to other endoscopy-related field of interest, such as gastroscopy and arthroscopy. The principle of the method is first exposed, then filtering procedure used to extract the depth information is described. Finally, demonstration of the method ability to operate on biological samples is assessed through measurements on ex-vivo pork bronchi.

Perspective: Theory and simulation of hybrid halide perovskites

PubMed Central

Jung, Young-Kwang

2017-01-01

Organic-inorganic halide perovskites present a number of challenges for first-principles atomistic materials modeling. Such “plastic crystals” feature dynamic processes across multiple length and time scales. These include the following: (i) transport of slow ions and fast electrons; (ii) highly anharmonic lattice dynamics with short phonon lifetimes; (iii) local symmetry breaking of the average crystallographic space group; (iv) strong relativistic (spin-orbit coupling) effects on the electronic band structure; and (v) thermodynamic metastability and rapid chemical breakdown. These issues, which affect the operation of solar cells, are outlined in this perspective. We also discuss general guidelines for performing quantitative and predictive simulations of these materials, which are relevant to metal-organic frameworks and other hybrid semiconducting, dielectric and ferroelectric compounds. PMID:29166078

A new method of search design of refrigerating systems containing a liquid and gaseous working medium based on the graph model of the physical operating principle

NASA Astrophysics Data System (ADS)

Yakovlev, A. A.; Sorokin, V. S.; Mishustina, S. N.; Proidakova, N. V.; Postupaeva, S. G.

2017-01-01

The article describes a new method of search design of refrigerating systems, the basis of which is represented by a graph model of the physical operating principle based on thermodynamical description of physical processes. The mathematical model of the physical operating principle has been substantiated, and the basic abstract theorems relatively semantic load applied to nodes and edges of the graph have been represented. The necessity and the physical operating principle, sufficient for the given model and intended for the considered device class, were demonstrated by the example of a vapour-compression refrigerating plant. The example of obtaining a multitude of engineering solutions of a vapour-compression refrigerating plant has been considered.

6 Principles for Quantitative Reasoning and Modeling

ERIC Educational Resources Information Center

Weber, Eric; Ellis, Amy; Kulow, Torrey; Ozgur, Zekiye

2014-01-01

Encouraging students to reason with quantitative relationships can help them develop, understand, and explore mathematical models of real-world phenomena. Through two examples--modeling the motion of a speeding car and the growth of a Jactus plant--this article describes how teachers can use six practical tips to help students develop quantitative…

40 CFR Appendix F to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Nitrogen Dioxide in the...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) EC08NO91.075 The quantitative nature of this reaction is such that when the NO concentration is known, the... material, for the quantitative reaction of O3 with excess NO. The chamber should be of sufficient volume (V... lower than 2.75 ppm-minutes may be used if it can be determined empirically that quantitative reaction...

40 CFR Appendix F to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Nitrogen Dioxide in the...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) EC08NO91.075 The quantitative nature of this reaction is such that when the NO concentration is known, the... material, for the quantitative reaction of O3 with excess NO. The chamber should be of sufficient volume (V... lower than 2.75 ppm-minutes may be used if it can be determined empirically that quantitative reaction...

40 CFR Appendix F to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Nitrogen Dioxide in the...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) EC08NO91.075 The quantitative nature of this reaction is such that when the NO concentration is known, the... material, for the quantitative reaction of O3 with excess NO. The chamber should be of sufficient volume (V... lower than 2.75 ppm-minutes may be used if it can be determined empirically that quantitative reaction...

40 CFR Appendix F to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Nitrogen Dioxide in the...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) EC08NO91.075 The quantitative nature of this reaction is such that when the NO concentration is known, the... material, for the quantitative reaction of O3 with excess NO. The chamber should be of sufficient volume (V... lower than 2.75 ppm-minutes may be used if it can be determined empirically that quantitative reaction...

40 CFR Appendix F to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Nitrogen Dioxide in the...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) EC08NO91.075 The quantitative nature of this reaction is such that when the NO concentration is known, the... material, for the quantitative reaction of O3 with excess NO. The chamber should be of sufficient volume (V... lower than 2.75 ppm-minutes may be used if it can be determined empirically that quantitative reaction...

Does the Relative Strength of Grouping Principles Modulate the Interactions between them?

PubMed

Montoro, Pedro R; Luna, Dolores

2015-06-05

This study examines the influence of the relative strength of grouping principles on interactions between the intrinsic principle of proximity and the extrinsic principle of common region in the process of perceptual organization. Cooperation and competition between intrinsic and extrinsic principles were examined by presenting the principle either alone or conjoined with another principle. The relative grouping strength of the principles operating alone was varied in two different groups of participants so that it was similar for one group and very different for the other group. Results showed that, when principles acting alone had different strengths, the grouping effect of the strongest principle was similar to that of the cooperation condition, and the effect of the weakest principle was similar to that of competing conjoined principles. In contrast, when the strength of principles acting alone was similar, the effect of conjoined cooperating principles was greater than that of either principle acting alone. Moreover, the effect of conjoined competing principles was smaller than that of either principle operating alone. Results show that cooperation and competition between intrinsic and extrinsic principles are modulated by the relative grouping strength of principles acting alone. Furthermore, performance in these conditions could be predicted on the basis of performance in single-principle conditions.

Quantitation of Localized 31P Magnetic Resonance Spectra Based on the Reciprocity Principle

NASA Astrophysics Data System (ADS)

Kreis, R.; Slotboom, J.; Pietz, J.; Jung, B.; Boesch, C.

2001-04-01

There is a need for absolute quantitation methods in 31P magnetic resonance spectroscopy, because none of the phosphorous-containing metabolites is necessarily constant in pathology. Here, a method for absolute quantitation of in vivo31P MR spectra that provides reproducible metabolite contents in institutional or standard units is described. It relies on the reciprocity principle, i.e., the proportionality between the B1 field map and the map of reception strength for a coil with identical relative current distributions in receive and transmit mode. Cerebral tissue contents of 31P metabolites were determined in a predominantly white matter-containing location in healthy subjects. The results are in good agreement with the literature and the interexamination coefficient of variance is better than that in most previous studies. A gender difference found for some of the 31P metabolites may be explained by different voxel composition.

Protecting solid-state spins from a strongly coupled environment

NASA Astrophysics Data System (ADS)

Chen, Mo; Calvin Sun, Won Kyu; Saha, Kasturi; Jaskula, Jean-Christophe; Cappellaro, Paola

2018-06-01

Quantum memories are critical for solid-state quantum computing devices and a good quantum memory requires both long storage time and fast read/write operations. A promising system is the nitrogen-vacancy (NV) center in diamond, where the NV electronic spin serves as the computing qubit and a nearby nuclear spin as the memory qubit. Previous works used remote, weakly coupled 13C nuclear spins, trading read/write speed for long storage time. Here we focus instead on the intrinsic strongly coupled 14N nuclear spin. We first quantitatively understand its decoherence mechanism, identifying as its source the electronic spin that acts as a quantum fluctuator. We then propose a scheme to protect the quantum memory from the fluctuating noise by applying dynamical decoupling on the environment itself. We demonstrate a factor of 3 enhancement of the storage time in a proof-of-principle experiment, showing the potential for a quantum memory that combines fast operation with long coherence time.

Modeling Bottom Sediment Erosion Process by Swirling the Flow by Tangential Supply of Oil in the Tank

NASA Astrophysics Data System (ADS)

Nekrasov, V. O.

2016-10-01

The article carries out a statistical data processing of quantitative and territorial division of oil tanks operating in Tyumen region, intended for reception, storage and distribution of commercial oil through trunk pipelines. It describes the working principle of the new device of erosion and prevention of oil bottom sediment formation with tangential supply of oil pumped into reservoir. The most significant similarity criteria can be emphasized in modeling rotational flows exerting significant influence on the structure of the circulating flow of oil in tank when operation of the device described. The dependence of the distribution of the linear velocity of a point on the surface along the radius at the circular motion of the oil in the tank is characterized, and on the basis of this dependence, a formula of general kinetic energy of rotational motion of oil and asphalt-resin-paraffin deposits total volume in the oil reservoir is given.

Finite-temperature Gutzwiller approximation from the time-dependent variational principle

NASA Astrophysics Data System (ADS)

Lanatà, Nicola; Deng, Xiaoyu; Kotliar, Gabriel

2015-08-01

We develop an extension of the Gutzwiller approximation to finite temperatures based on the Dirac-Frenkel variational principle. Our method does not rely on any entropy inequality, and is substantially more accurate than the approaches proposed in previous works. We apply our theory to the single-band Hubbard model at different fillings, and show that our results compare quantitatively well with dynamical mean field theory in the metallic phase. We discuss potential applications of our technique within the framework of first-principle calculations.

A miniaturized optoelectronic system for rapid quantitative label-free detection of harmful species in food

NASA Astrophysics Data System (ADS)

Raptis, Ioannis; Misiakos, Konstantinos; Makarona, Eleni; Salapatas, Alexandros; Petrou, Panagiota; Kakabakos, Sotirios; Botsialas, Athanasios; Jobst, Gerhard; Haasnoot, Willem; Fernandez-Alba, Amadeo; Lees, Michelle; Valamontes, Evangelos

2016-03-01

Optical biosensors have emerged in the past decade as the most promising candidates for portable, highly-sensitive bioanalytical systems that can be employed for in-situ measurements. In this work, a miniaturized optoelectronic system for rapid, quantitative, label-free detection of harmful species in food is presented. The proposed system has four distinctive features that can render to a powerful tool for the next generation of Point-of-Need applications, namely it accommodates the light sources and ten interferometric biosensors on a single silicon chip of a less-than-40mm2 footprint, each sensor can be individually functionalized for a specific target analyte, the encapsulation can be performed at the wafer-scale, and finally it exploits a new operation principle, Broad-band Mach-Zehnder Interferometry to ameliorate its analytical capabilities. Multi-analyte evaluation schemes for the simultaneous detection of harmful contaminants, such as mycotoxins, allergens and pesticides, proved that the proposed system is capable of detecting within short time these substances at concentrations below the limits imposed by regulatory authorities, rendering it to a novel tool for the near-future food safety applications.

Principled negotiation and distributed optimization for advanced air traffic management

NASA Astrophysics Data System (ADS)

Wangermann, John Paul

Today's aircraft/airspace system faces complex challenges. Congestion and delays are widespread as air traffic continues to grow. Airlines want to better optimize their operations, and general aviation wants easier access to the system. Additionally, the accident rate must decline just to keep the number of accidents each year constant. New technology provides an opportunity to rethink the air traffic management process. Faster computers, new sensors, and high-bandwidth communications can be used to create new operating models. The choice is no longer between "inflexible" strategic separation assurance and "flexible" tactical conflict resolution. With suitable operating procedures, it is possible to have strategic, four-dimensional separation assurance that is flexible and allows system users maximum freedom to optimize operations. This thesis describes an operating model based on principled negotiation between agents. Many multi-agent systems have agents that have different, competing interests but have a shared interest in coordinating their actions. Principled negotiation is a method of finding agreement between agents with different interests. By focusing on fundamental interests and searching for options for mutual gain, agents with different interests reach agreements that provide benefits for both sides. Using principled negotiation, distributed optimization by each agent can be coordinated leading to iterative optimization of the system. Principled negotiation is well-suited to aircraft/airspace systems. It allows aircraft and operators to propose changes to air traffic control. Air traffic managers check the proposal maintains required aircraft separation. If it does, the proposal is either accepted or passed to agents whose trajectories change as part of the proposal for approval. Aircraft and operators can use all the data at hand to develop proposals that optimize their operations, while traffic managers can focus on their primary duty of ensuring aircraft safety. This thesis describes how an aircraft/airspace system using principled negotiation operates, and reports simulation results on the concept. The results show safety is maintained while aircraft have freedom to optimize their operations.

A Quantitative Evaluation of the Flipped Classroom in a Large Lecture Principles of Economics Course

ERIC Educational Resources Information Center

Balaban, Rita A.; Gilleskie, Donna B.; Tran, Uyen

2016-01-01

This research provides evidence that the flipped classroom instructional format increases student final exam performance, relative to the traditional instructional format, in a large lecture principles of economics course. The authors find that the flipped classroom directly improves performance by 0.2 to 0.7 standardized deviations, depending on…

Preliminary research on quantitative methods of water resources carrying capacity based on water resources balance sheet

NASA Astrophysics Data System (ADS)

Wang, Yanqiu; Huang, Xiaorong; Gao, Linyun; Guo, Biying; Ma, Kai

2018-06-01

Water resources are not only basic natural resources, but also strategic economic resources and ecological control factors. Water resources carrying capacity constrains the sustainable development of regional economy and society. Studies of water resources carrying capacity can provide helpful information about how the socioeconomic system is both supported and restrained by the water resources system. Based on the research of different scholars, major problems in the study of water resources carrying capacity were summarized as follows: the definition of water resources carrying capacity is not yet unified; the methods of carrying capacity quantification based on the definition of inconsistency are poor in operability; the current quantitative research methods of water resources carrying capacity did not fully reflect the principles of sustainable development; it is difficult to quantify the relationship among the water resources, economic society and ecological environment. Therefore, it is necessary to develop a better quantitative evaluation method to determine the regional water resources carrying capacity. This paper proposes a new approach to quantifying water resources carrying capacity (that is, through the compilation of the water resources balance sheet) to get a grasp of the regional water resources depletion and water environmental degradation (as well as regional water resources stock assets and liabilities), figure out the squeeze of socioeconomic activities on the environment, and discuss the quantitative calculation methods and technical route of water resources carrying capacity which are able to embody the substance of sustainable development.

Measurement Invariance: A Foundational Principle for Quantitative Theory Building

ERIC Educational Resources Information Center

Nimon, Kim; Reio, Thomas G., Jr.

2011-01-01

This article describes why measurement invariance is a critical issue to quantitative theory building within the field of human resource development. Readers will learn what measurement invariance is and how to test for its presence using techniques that are accessible to applied researchers. Using data from a LibQUAL+[TM] study of user…

QuantCrit: Education, Policy, "Big Data" and Principles for a Critical Race Theory of Statistics

ERIC Educational Resources Information Center

Gillborn, David; Warmington, Paul; Demack, Sean

2018-01-01

Quantitative research enjoys heightened esteem among policy-makers, media, and the general public. Whereas qualitative research is frequently dismissed as subjective and impressionistic, statistics are often assumed to be objective and factual. We argue that these distinctions are wholly false; quantitative data is no less socially constructed…

Quantitative measures for redox signaling.

PubMed

Pillay, Ché S; Eagling, Beatrice D; Driscoll, Scott R E; Rohwer, Johann M

2016-07-01

Redox signaling is now recognized as an important regulatory mechanism for a number of cellular processes including the antioxidant response, phosphokinase signal transduction and redox metabolism. While there has been considerable progress in identifying the cellular machinery involved in redox signaling, quantitative measures of redox signals have been lacking, limiting efforts aimed at understanding and comparing redox signaling under normoxic and pathogenic conditions. Here we have outlined some of the accepted principles for redox signaling, including the description of hydrogen peroxide as a signaling molecule and the role of kinetics in conferring specificity to these signaling events. Based on these principles, we then develop a working definition for redox signaling and review a number of quantitative methods that have been employed to describe signaling in other systems. Using computational modeling and published data, we show how time- and concentration- dependent analyses, in particular, could be used to quantitatively describe redox signaling and therefore provide important insights into the functional organization of redox networks. Finally, we consider some of the key challenges with implementing these methods. Copyright © 2016 Elsevier Inc. All rights reserved.

Complexity-aware simple modeling.

PubMed

Gómez-Schiavon, Mariana; El-Samad, Hana

2018-02-26

Mathematical models continue to be essential for deepening our understanding of biology. On one extreme, simple or small-scale models help delineate general biological principles. However, the parsimony of detail in these models as well as their assumption of modularity and insulation make them inaccurate for describing quantitative features. On the other extreme, large-scale and detailed models can quantitatively recapitulate a phenotype of interest, but have to rely on many unknown parameters, making them often difficult to parse mechanistically and to use for extracting general principles. We discuss some examples of a new approach-complexity-aware simple modeling-that can bridge the gap between the small-scale and large-scale approaches. Copyright © 2018 Elsevier Ltd. All rights reserved.

[The 80-th anniversary of the use of an operating microscope in otorhinolaryngology. Part II. Technical principle and operation of surgical microscope].

PubMed

Mroczkowski, Edward; Wielgosz, Romuald

2004-01-01

The first step to microsurgery is getting to know about technical principle and operation of the surgical microscopes. Special attention is paid to those modules and items of microscopes, which surgeon use most frequently, such as objectives, binocular tubes, eyepieces.

Beyond Mission Command: Maneuver Warfare for Cyber Command and Control

DTIC Science & Technology

2015-05-18

operation in an A2AD environment. 15. SUBJECT TERMS command and control; maneuver warfare; cyberspace; cyberspace operations; cyber warfare , mission...Some Principles of Cyber Warfare (NWC 2160) (U.S. Naval War College, Joint Military Operations Department, Newport, RI: U.S. Naval War College...research/ innovationleadership.pdf. Crowell, Richard M. Some Principles of Cyber Warfare (NWC 2160). U.S. Naval War College, Joint Military Operations

21 CFR 814.39 - PMA supplements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... sterilization procedures. (5) Changes in packaging. (6) Changes in the performance or design specifications, circuits, components, ingredients, principle of operation, or physical layout of the device. (7) Extension... the performance or design specifications, circuits, components, ingredients, principles of operation...

Integrated and Contextual Basic Science Instruction in Preclinical Education: Problem-Based Learning Experience Enriched with Brain/Mind Learning Principles

ERIC Educational Resources Information Center

Gülpinar, Mehmet Ali; Isoglu-Alkaç, Ümmühan; Yegen, Berrak Çaglayan

2015-01-01

Recently, integrated and contextual learning models such as problem-based learning (PBL) and brain/mind learning (BML) have become prominent. The present study aimed to develop and evaluate a PBL program enriched with BML principles. In this study, participants were 295 first-year medical students. The study used both quantitative and qualitative…

Stand-off thermal IR minefield survey: system concept and experimental results

NASA Astrophysics Data System (ADS)

Cremer, Frank; Nguyen, Thanh T.; Yang, Lixin; Sahli, Hichem

2005-06-01

A detailed description of the CLEARFAST system for thermal IR stand-off minefield survey is given. The system allows (i) a stand-off diurnal observation of hazardous area, (ii) detecting anomalies, i.e. locating and searching for targets which are thermally and spectrally distinct from their surroundings, (iii) estimating the physical parameters, i.e. depth and thermal diffusivity, of the detected anomalies, and (iv) providing panoramic (mosaic) images indicating the locations of suspect objects and known markers. The CLEARFAST demonstrator has been successfully deployed and operated, in November 2004, in a real minefield within the United Nations Buffer Zone in Cyprus. The paper describes the main principles of the system and illustrates the processing chain on a set of real minefield images, together with qualitative and quantitative results.

75 FR 18146 - South Central Idaho Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... operating principles and project proposals. DATES: The meeting will be held May 17, 2010 from 1:30 p.m.-3:30... specifically deal with Operating principles and project proposals that the RAC will use to implement the...

Human factors in operations design

NASA Technical Reports Server (NTRS)

Chafin, R. L.

1982-01-01

The manner in which organizations develop their organizational structure is considered, taking into account an example in which the environment changes for an older organization. In such cases, it would be preferable to have some theoretical foundation on which to base the restructuring of the organization to meet new environmental needs. A description is given of a theoretic foundation based on the principles of Differentiation/Integration and Procedural/Knowledge based operations. The organizational design principle of Differentiation and Integration has been presented by Lawrence and Lorsch (1969). The differentiation/integration processes are related to the organizational structures presented in studies concerning NASA Deep Space Network (DSN) operations. The principles presented provide valuable tools for analyzing operations organization.

Layout and flow of dermatology clinics: principles from operations management.

PubMed

Wang, Jordan V

2018-04-15

Dermatology is a medical specialty that experiences high patient demand and long patient wait times. Dermatology clinics should look for ways to improve efficiency through the incorporation of principles from operations management. Addressing the layout and flow of a clinic can lead to operational efficiency. An ideal layout may lead to increased patient volume, satisfaction, and retention.

Operator's manual on the visual-accumulation tube method for sedimentation analysis of sands

USGS Publications Warehouse

Colby, V.C.; Witzgman, F.W.

1958-01-01

The personnel who will be operating these units may have little or no previous knowledge of either the principles involved or the details of opera.ting procedure. This manual is intended as an aid to them in setting up the apparatus, learning the analytical procedure, interpreting the results, and understanding the primary principles encountered.

Determination of Calcium in Cereal with Flame Atomic Absorption Spectroscopy: An Experiment for a Quantitative Methods of Analysis Course

ERIC Educational Resources Information Center

Bazzi, Ali; Kreuz, Bette; Fischer, Jeffrey

2004-01-01

An experiment for determination of calcium in cereal using two-increment standard addition method in conjunction with flame atomic absorption spectroscopy (FAAS) is demonstrated. The experiment is intended to introduce students to the principles of atomic absorption spectroscopy giving them hands on experience using quantitative methods of…

Implementing Response to Intervention in Title I Elementary Schools: A Quantitative Study of Teacher Response Relationships

ERIC Educational Resources Information Center

Webster, Katina F.

2012-01-01

General educators and special educators in Title I elementary schools perceive the relationships between principles of RTI and their state RTI framework, the implementation of RTI, and professional development received in RTI differently. A quantitative survey-based research methodology was employed including the use of Cronbach's alpha to…

Teaching Children How to Include the Inversion Principle in Their Reasoning about Quantitative Relations

ERIC Educational Resources Information Center

Nunes, Terezinha; Bryant, Peter; Evans, Deborah; Bell, Daniel; Barros, Rossana

2012-01-01

The basis of this intervention study is a distinction between numerical calculus and relational calculus. The former refers to numerical calculations and the latter to the analysis of the quantitative relations in mathematical problems. The inverse relation between addition and subtraction is relevant to both kinds of calculus, but so far research…

Practical Stereology Applications for the Pathologist.

PubMed

Brown, Danielle L

2017-05-01

Qualitative histopathology is the gold standard for routine examination of morphological tissue changes in the regulatory or academic environment. The human eye is exceptional for pattern recognition but often cannot detect small changes in quantity. In cases where detection of subtle quantitative changes is critical, more sensitive methods are required. Two-dimensional histomorphometry can provide additional quantitative information and is quite useful in many cases. However, the provided data may not be referent to the entire tissue and, as such, it makes several assumptions, which are sources of bias. In contrast, stereology is design based rather than assumption based and uses stringent sampling methods to obtain accurate and precise 3-dimensional information using geometrical and statistical principles. Recent advances in technology have made stereology more approachable and practical for the pathologist in both regulatory and academic environments. This review introduces pathologists to the basic principles of stereology and walks the reader through some real-world examples for the application of these principles in the workplace.

Analytical insight into "breathing" crack-induced acoustic nonlinearity with an application to quantitative evaluation of contact cracks.

PubMed

Wang, Kai; Liu, Menglong; Su, Zhongqing; Yuan, Shenfang; Fan, Zheng

2018-08-01

To characterize fatigue cracks, in the undersized stage in particular, preferably in a quantitative and precise manner, a two-dimensional (2D) analytical model is developed for interpreting the modulation mechanism of a "breathing" crack on guided ultrasonic waves (GUWs). In conjunction with a modal decomposition method and a variational principle-based algorithm, the model is capable of analytically depicting the propagating and evanescent waves induced owing to the interaction of probing GUWs with a "breathing" crack, and further extracting linear and nonlinear wave features (e.g., reflection, transmission, mode conversion and contact acoustic nonlinearity (CAN)). With the model, a quantitative correlation between CAN embodied in acquired GUWs and crack parameters (e.g., location and severity) is obtained, whereby a set of damage indices is proposed via which the severity of the crack can be evaluated quantitatively. The evaluation, in principle, does not entail a benchmarking process against baseline signals. As validation, the results obtained from the analytical model are compared with those from finite element simulation, showing good consistency. This has demonstrated accuracy of the developed analytical model in interpreting contact crack-induced CAN, and spotlighted its application to quantitative evaluation of fatigue damage. Copyright © 2018 Elsevier B.V. All rights reserved.

Variation Principles and Applications in the Study of Cell Structure and Aging

NASA Technical Reports Server (NTRS)

Economos, Angelos C.; Miquel, Jaime; Ballard, Ralph C.; Johnson, John E., Jr.

1981-01-01

In this report we have attempted to show that "some reality lies concealed in biological variation". This "reality" has its principles, laws, mechanisms, and rules, only a few of which we have sketched. A related idea we pursued was that important information may be lost in the process of ignoring frequency distributions of physiological variables (as is customary in experimental physiology and gerontology). We suggested that it may be advantageous to expand one's "statistical field of vision" beyond simple averages +/- standard deviations. Indeed, frequency distribution analysis may make visible some hidden information not evident from a simple qualitative analysis, particularly when the effect of some external factor or condition (e.g., aging, dietary chemicals) is being investigated. This was clearly illustrated by the application of distribution analysis in the study of variation in mouse liver cellular and fine structure, and may be true of fine structural studies in general. In living systems, structure and function interact in a dynamic way; they are "inseparable," unlike in technological systems or machines. Changes in fine structure therefore reflect changes in function. If such changes do not exceed a certain physiologic range, a quantitative analysis of structure will provide valuable information on quantitative changes in function that may not be possible or easy to measure directly. Because there is a large inherent variation in fine structure of cells in a given organ of an individual and among individuals, changes in fine structure can be analyzed only by studying frequency distribution curves of various structural characteristics (dimensions). Simple averages +/- S.D. do not in general reveal all information on the effect of a certain factor, because often this effect is not uniform; on the contrary, this will be apparent from distribution analysis because the form of the curves will be affected. We have also attempted to show in this chapter that similar general statistical principles and mechanisms may be operative in biological and technological systems. Despite the common belief that most biological and technological characteristics of interest have a symmetric bell-shaped (normal or Gaussian) distribution, we have shown that more often than not, distributions tend to be asymmetric and often resemble a so-called log-normal distribution. We saw that at least three general mechanisms may be operative, i.e., nonadditivity of influencing factors, competition among individuals for a common resource, and existence of an "optimum" value for a studied characteristic; more such mechanisms could exist.

Metabolic networks evolve towards states of maximum entropy production.

PubMed

Unrean, Pornkamol; Srienc, Friedrich

2011-11-01

A metabolic network can be described by a set of elementary modes or pathways representing discrete metabolic states that support cell function. We have recently shown that in the most likely metabolic state the usage probability of individual elementary modes is distributed according to the Boltzmann distribution law while complying with the principle of maximum entropy production. To demonstrate that a metabolic network evolves towards such state we have carried out adaptive evolution experiments with Thermoanaerobacterium saccharolyticum operating with a reduced metabolic functionality based on a reduced set of elementary modes. In such reduced metabolic network metabolic fluxes can be conveniently computed from the measured metabolite secretion pattern. Over a time span of 300 generations the specific growth rate of the strain continuously increased together with a continuous increase in the rate of entropy production. We show that the rate of entropy production asymptotically approaches the maximum entropy production rate predicted from the state when the usage probability of individual elementary modes is distributed according to the Boltzmann distribution. Therefore, the outcome of evolution of a complex biological system can be predicted in highly quantitative terms using basic statistical mechanical principles. Copyright © 2011 Elsevier Inc. All rights reserved.

Alert-QSAR. Implications for Electrophilic Theory of Chemical Carcinogenesis

PubMed Central

Putz, Mihai V.; Ionaşcu, Cosmin; Putz, Ana-Maria; Ostafe, Vasile

2011-01-01

Given the modeling and predictive abilities of quantitative structure activity relationships (QSARs) for genotoxic carcinogens or mutagens that directly affect DNA, the present research investigates structural alert (SA) intermediate-predicted correlations ASA of electrophilic molecular structures with observed carcinogenic potencies in rats (observed activity, A = Log[1/TD50], i.e., ASA=f(X1SA,X2SA,…)). The present method includes calculation of the recently developed residual correlation of the structural alert models, i.e., ARASA=f(A−ASA,X1SA,X2SA,…). We propose a specific electrophilic ligand-receptor mechanism that combines electronegativity with chemical hardness-associated frontier principles, equality of ligand-reagent electronegativities and ligand maximum chemical hardness for highly diverse toxic molecules against specific receptors in rats. The observed carcinogenic activity is influenced by the induced SA-mutagenic intermediate effect, alongside Hansch indices such as hydrophobicity (LogP), polarizability (POL) and total energy (Etot), which account for molecular membrane diffusion, ionic deformation, and stericity, respectively. A possible QSAR mechanistic interpretation of mutagenicity as the first step in genotoxic carcinogenesis development is discussed using the structural alert chemoinformation and in full accordance with the Organization for Economic Co-operation and Development QSAR guidance principles. PMID:21954348

SIMPLE estimate of the free energy change due to aliphatic mutations: superior predictions based on first principles.

PubMed

Bueno, Marta; Camacho, Carlos J; Sancho, Javier

2007-09-01

The bioinformatics revolution of the last decade has been instrumental in the development of empirical potentials to quantitatively estimate protein interactions for modeling and design. Although computationally efficient, these potentials hide most of the relevant thermodynamics in 5-to-40 parameters that are fitted against a large experimental database. Here, we revisit this longstanding problem and show that a careful consideration of the change in hydrophobicity, electrostatics, and configurational entropy between the folded and unfolded state of aliphatic point mutations predicts 20-30% less false positives and yields more accurate predictions than any published empirical energy function. This significant improvement is achieved with essentially no free parameters, validating past theoretical and experimental efforts to understand the thermodynamics of protein folding. Our first principle analysis strongly suggests that both the solute-solute van der Waals interactions in the folded state and the electrostatics free energy change of exposed aliphatic mutations are almost completely compensated by similar interactions operating in the unfolded ensemble. Not surprisingly, the problem of properly accounting for the solvent contribution to the free energy of polar and charged group mutations, as well as of mutations that disrupt the protein backbone remains open. 2007 Wiley-Liss, Inc.

Baseline-free damage detection in composite plates based on the reciprocity principle

NASA Astrophysics Data System (ADS)

Huang, Liping; Zeng, Liang; Lin, Jing

2018-01-01

Lamb wave based damage detection techniques have been widely used in composite structures. In particular, these techniques usually rely on reference signals, which are significantly influenced by the operational and environmental conditions. To solve this issue, this paper presents a baseline-free damage inspection method based on the reciprocity principle. If a localized nonlinear scatterer exists along the wave path, the reciprocity breaks down. Through estimating the loss of reciprocity, the delamination could be detected. A reciprocity index (RI), which compares the discrepancy between the signal received in transducer B when emitting from transducer A and the signal received in A when the same source is located in B, is established to quantitatively analyze the reciprocity. Experimental results show that the RI value of a damaged path is much higher than that of a healthy path. In addition, the effects of the parameters of excitation signal (i.e., central frequency and bandwidth) and the position of delamination on the RI value are discussed. Furthermore, a RI based probabilistic imaging algorithm is proposed for detecting delamination damage of composite plates without reference signals. Finally, the effectiveness of this baseline-free damage detection method is validated by an experimental example.

National Principles of War: Guiding National Power to Victory

DTIC Science & Technology

2006-05-26

label the principles as more Principles of Battle7 than Principles of War. As John I. Alger remarked in his book on the history of the Principles of War...better suited to be Principles of Military Operations than National Principles of War. In his The Quest for Victory, John I. Alger recognizes three...mentioned work, John Alger discusses same those principles but adds the principle unity of command. Not only was this a crucial time for the development of

47 CFR 36.2 - Fundamental principles underlying procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Fundamental principles underlying procedures... Fundamental principles underlying procedures. (a) The following general principles underlie the procedures... operating forces on a unit basis (e.g., conversation-minute-kilometers per message, weighted standard work...

Comparing Pre- and Post-Operative Fontan Hemodynamic Simulations: Implications for the Reliability of Surgical Planning

PubMed Central

Haggerty, Christopher M.; de Zélicourt, Diane A.; Restrepo, Maria; Rossignac, Jarek; Spray, Thomas L.; Kanter, Kirk R.; Fogel, Mark A.; Yoganathan, Ajit P.

2012-01-01

Background Virtual modeling of cardiothoracic surgery is a new paradigm that allows for systematic exploration of various operative strategies and uses engineering principles to predict the optimal patient-specific plan. This study investigates the predictive accuracy of such methods for the surgical palliation of single ventricle heart defects. Methods Computational fluid dynamics (CFD)-based surgical planning was used to model the Fontan procedure for four patients prior to surgery. The objective for each was to identify the operative strategy that best distributed hepatic blood flow to the pulmonary arteries. Post-operative magnetic resonance data were acquired to compare (via CFD) the post-operative hemodynamics with predictions. Results Despite variations in physiologic boundary conditions (e.g., cardiac output, venous flows) and the exact geometry of the surgical baffle, sufficient agreement was observed with respect to hepatic flow distribution (90% confidence interval-14 ± 4.3% difference). There was also good agreement of flow-normalized energetic efficiency predictions (19 ± 4.8% error). Conclusions The hemodynamic outcomes of prospective patient-specific surgical planning of the Fontan procedure are described for the first time with good quantitative comparisons between preoperatively predicted and postoperative simulations. These results demonstrate that surgical planning can be a useful tool for single ventricle cardiothoracic surgery with the ability to deliver significant clinical impact. PMID:22777126

Quantitative prediction of solute strengthening in aluminium alloys.

PubMed

Leyson, Gerard Paul M; Curtin, William A; Hector, Louis G; Woodward, Christopher F

2010-09-01

Despite significant advances in computational materials science, a quantitative, parameter-free prediction of the mechanical properties of alloys has been difficult to achieve from first principles. Here, we present a new analytic theory that, with input from first-principles calculations, is able to predict the strengthening of aluminium by substitutional solute atoms. Solute-dislocation interaction energies in and around the dislocation core are first calculated using density functional theory and a flexible-boundary-condition method. An analytic model for the strength, or stress to move a dislocation, owing to the random field of solutes, is then presented. The theory, which has no adjustable parameters and is extendable to other metallic alloys, predicts both the energy barriers to dislocation motion and the zero-temperature flow stress, allowing for predictions of finite-temperature flow stresses. Quantitative comparisons with experimental flow stresses at temperature T=78 K are made for Al-X alloys (X=Mg, Si, Cu, Cr) and good agreement is obtained.

How quantitative measures unravel design principles in multi-stage phosphorylation cascades.

PubMed

Frey, Simone; Millat, Thomas; Hohmann, Stefan; Wolkenhauer, Olaf

2008-09-07

We investigate design principles of linear multi-stage phosphorylation cascades by using quantitative measures for signaling time, signal duration and signal amplitude. We compare alternative pathway structures by varying the number of phosphorylations and the length of the cascade. We show that a model for a weakly activated pathway does not reflect the biological context well, unless it is restricted to certain parameter combinations. Focusing therefore on a more general model, we compare alternative structures with respect to a multivariate optimization criterion. We test the hypothesis that the structure of a linear multi-stage phosphorylation cascade is the result of an optimization process aiming for a fast response, defined by the minimum of the product of signaling time and signal duration. It is then shown that certain pathway structures minimize this criterion. Several popular models of MAPK cascades form the basis of our study. These models represent different levels of approximation, which we compare and discuss with respect to the quantitative measures.

Software for quantitative analysis of radiotherapy: overview, requirement analysis and design solutions.

PubMed

Zhang, Lanlan; Hub, Martina; Mang, Sarah; Thieke, Christian; Nix, Oliver; Karger, Christian P; Floca, Ralf O

2013-06-01

Radiotherapy is a fast-developing discipline which plays a major role in cancer care. Quantitative analysis of radiotherapy data can improve the success of the treatment and support the prediction of outcome. In this paper, we first identify functional, conceptional and general requirements on a software system for quantitative analysis of radiotherapy. Further we present an overview of existing radiotherapy analysis software tools and check them against the stated requirements. As none of them could meet all of the demands presented herein, we analyzed possible conceptional problems and present software design solutions and recommendations to meet the stated requirements (e.g. algorithmic decoupling via dose iterator pattern; analysis database design). As a proof of concept we developed a software library "RTToolbox" following the presented design principles. The RTToolbox is available as open source library and has already been tested in a larger-scale software system for different use cases. These examples demonstrate the benefit of the presented design principles. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Portable paper-based device for quantitative colorimetric assays relying on light reflectance principle.

PubMed

Li, Bowei; Fu, Longwen; Zhang, Wei; Feng, Weiwei; Chen, Lingxin

2014-04-01

This paper presents a novel paper-based analytical device based on the colorimetric paper assays through its light reflectance. The device is portable, low cost (<20 dollars), and lightweight (only 176 g) that is available to assess the cost-effectiveness and appropriateness of the original health care or on-site detection information. Based on the light reflectance principle, the signal can be obtained directly, stably and user-friendly in our device. We demonstrated the utility and broad applicability of this technique with measurements of different biological and pollution target samples (BSA, glucose, Fe, and nitrite). Moreover, the real samples of Fe (II) and nitrite in the local tap water were successfully analyzed, and compared with the standard UV absorption method, the quantitative results showed good performance, reproducibility, and reliability. This device could provide quantitative information very conveniently and show great potential to broad fields of resource-limited analysis, medical diagnostics, and on-site environmental detection. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Meeting Report: Tissue-based Image Analysis.

PubMed

Saravanan, Chandra; Schumacher, Vanessa; Brown, Danielle; Dunstan, Robert; Galarneau, Jean-Rene; Odin, Marielle; Mishra, Sasmita

2017-10-01

Quantitative image analysis (IA) is a rapidly evolving area of digital pathology. Although not a new concept, the quantification of histological features on photomicrographs used to be cumbersome, resource-intensive, and limited to specialists and specialized laboratories. Recent technological advances like highly efficient automated whole slide digitizer (scanner) systems, innovative IA platforms, and the emergence of pathologist-friendly image annotation and analysis systems mean that quantification of features on histological digital images will become increasingly prominent in pathologists' daily professional lives. The added value of quantitative IA in pathology includes confirmation of equivocal findings noted by a pathologist, increasing the sensitivity of feature detection, quantification of signal intensity, and improving efficiency. There is no denying that quantitative IA is part of the future of pathology; however, there are also several potential pitfalls when trying to estimate volumetric features from limited 2-dimensional sections. This continuing education session on quantitative IA offered a broad overview of the field; a hands-on toxicologic pathologist experience with IA principles, tools, and workflows; a discussion on how to apply basic stereology principles in order to minimize bias in IA; and finally, a reflection on the future of IA in the toxicologic pathology field.

Shared perceptions: morality is embedded in social contexts.

PubMed

Carnes, Nate C; Lickel, Brian; Janoff-Bulman, Ronnie

2015-03-01

Morality helps make social life possible, but social life is embedded in many social contexts. Research on morality has generally neglected this and instead has emphasized people's general beliefs. We therefore investigated the extent to which different moral principles are perceived as embedded in social contexts. We conducted two studies investigating how diverse social contexts influence beliefs about the operative moral principles in distinct group types. Study 1 examined these perceptions using a within-subjects design, whereas Study 2 utilized a between-subjects design. We found a high degree of consensus among raters concerning the operative moral principles in groups, and each group type was characterized by a qualitatively distinct pattern of applicable moral principles. Political orientation, a focus of past research on morality, had a small influence on beliefs about operative moral principles. The implications of these findings for our understanding of morality and its functional role in groups are discussed. © 2015 by the Society for Personality and Social Psychology, Inc.

Principles of project management

NASA Technical Reports Server (NTRS)

1982-01-01

The basic principles of project management as practiced by NASA management personnel are presented. These principles are given as ground rules and guidelines to be used in the performance of research, development, construction or operational assignments.

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care.

PubMed

Steenkamer, Betty; Baan, Caroline; Putters, Kim; van Oers, Hans; Drewes, Hanneke

2018-04-09

Purpose A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative strategies to improve pharmaceutical care and the contextual factors and mechanisms through which these principles operate. Design/methodology/approach The evaluation was informed by a realist methodology examining the links between PHM strategies, their outcomes and the contexts and mechanisms by which these strategies operate. Guiding principles were identified by grouping context-specific strategies with specific outcomes. Findings In total, ten guiding principles were identified: create agreement and commitment based on a long-term vision; foster cooperation and representation at the board level; use layered governance structures; create awareness at all levels; enable interpersonal links at all levels; create learning environments; organize shared responsibility; adjust financial strategies to market contexts; organize mutual gains; and align regional agreements with national policies and regulations. Contextual factors such as shared savings influenced the effectiveness of the guiding principles. Mechanisms by which these guiding principles operate were, for instance, fostering trust and creating a shared sense of the problem. Practical implications The guiding principles highlight how collaboration can be stimulated to improve pharmaceutical care while taking into account local constraints and possibilities. The interdependency of these principles necessitates effectuating them together in order to realize the best possible improvements and outcomes. Originality/value This is the first study using a realist approach to understand the guiding principles underlying collaboration to improve pharmaceutical care.

CRAFT (complete reduction to amplitude frequency table)--robust and time-efficient Bayesian approach for quantitative mixture analysis by NMR.

PubMed

Krishnamurthy, Krish

2013-12-01

The intrinsic quantitative nature of NMR is increasingly exploited in areas ranging from complex mixture analysis (as in metabolomics and reaction monitoring) to quality assurance/control. Complex NMR spectra are more common than not, and therefore, extraction of quantitative information generally involves significant prior knowledge and/or operator interaction to characterize resonances of interest. Moreover, in most NMR-based metabolomic experiments, the signals from metabolites are normally present as a mixture of overlapping resonances, making quantification difficult. Time-domain Bayesian approaches have been reported to be better than conventional frequency-domain analysis at identifying subtle changes in signal amplitude. We discuss an approach that exploits Bayesian analysis to achieve a complete reduction to amplitude frequency table (CRAFT) in an automated and time-efficient fashion - thus converting the time-domain FID to a frequency-amplitude table. CRAFT uses a two-step approach to FID analysis. First, the FID is digitally filtered and downsampled to several sub FIDs, and secondly, these sub FIDs are then modeled as sums of decaying sinusoids using the Bayesian approach. CRAFT tables can be used for further data mining of quantitative information using fingerprint chemical shifts of compounds of interest and/or statistical analysis of modulation of chemical quantity in a biological study (metabolomics) or process study (reaction monitoring) or quality assurance/control. The basic principles behind this approach as well as results to evaluate the effectiveness of this approach in mixture analysis are presented. Copyright © 2013 John Wiley & Sons, Ltd.

Medical devices; hematology and pathology devices: reclassification of automated blood cell separator device operating by centrifugal separation principle. Final rule.

PubMed

2007-11-30

The Food and Drug Administration (FDA) is reclassifying from class III to class II the automated blood cell separator device operating by centrifugal separation principle and intended for the routine collection of blood and blood components. FDA is taking this action on its own initiative based on new information. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of a guidance document that will serve as the special controls for this device, as well as the special controls for the device with the same intended use but operating on a filtration separation principle.

76 FR 49841 - Transmission Planning and Cost Allocation by Transmission Owning and Operating Public Utilities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

.... Each cost allocation method must satisfy six cost allocation principles. DATES: Effective Date: This... 86 c. Commission Determination 99 3. Regional Transmission Planning Principles........ 118 a.... Principles for Regional and Interregional Cost 585 Allocation 1. Use of a Principles-Based Approach 585 a...

Fractography: determining the sites of fracture initiation.

PubMed

Mecholsky, J J

1995-03-01

Fractography is the analysis of fracture surfaces. Here, it refers to quantitative fracture surface analysis (FSA) in the context of applying the principles of fracture mechanics to the topography observed on the fracture surface of brittle materials. The application of FSA is based on the principle that encoded on the fracture surface of brittle materials is the entire history of the fracture process. It is our task to develop the skills and knowledge to decode this information. There are several motivating factors for applying our knowledge of FSA. The first and foremost is that there is specific, quantitative information to be obtained from the fracture surface. This information includes the identification of the size and location of the fracture initiating crack or defect, the stress state at failure, the existence, or not, of local or global residual stress, the existence, or not, of stress corrosion and a knowledge of local processing anomalies which affect the fracture process. The second motivating factor is that the information is free. Once a material is tested to failure, the encoded information becomes available. If we decide to observe the features produced during fracture then we are rewarded with much information. If we decide to ignore the fracture surface, then we are left to guess and/or reason as to the cause of the failure without the benefit of all of the possible information available. This paper addresses the application of quantitative fracture surface analysis to basic research, material and product development, and "trouble-shooting" of in-service failures. First, the basic principles involved will be presented. Next, the methodology necessary to apply the principles will be presented. Finally, a summary of the presentation will be made showing the applicability to design and reliability.

Basic hydraulic principles of open-channel flow

USGS Publications Warehouse

Jobson, Harvey E.; Froehlich, David C.

1988-01-01

The three basic principles of open-channel-flow analysis--the conservation of mass, energy, and momentum--are derived, explained, and applied to solve problems of open-channel flow. These principles are introduced at a level that can be comprehended by a person with an understanding of the principles of physics and mechanics equivalent to that presented in the first college level course of the subject. The reader is assumed to have a working knowledge of algebra and plane geometry as well as some knowledge of calculus. Once the principles have been derived, a number of example applications are presented that illustrate the computation of flow through culverts and bridges, and over structures, such as dams and weirs. Because resistance to flow is a major obstacle to the successful application of the energy principle to open-channel flow, procedures are outlined for the rational selection of flow resistance coefficients. The principle of specific energy is shown to be useful in the prediction of water-surface profiles both in the qualitative and quantitative sense. (USGS)

Bionanomaterials and Bioinspired Nanostructures for Selective Vapor Sensing

NASA Astrophysics Data System (ADS)

Potyrailo, Radislav; Naik, Rajesh R.

2013-07-01

At present, monitoring of air at the workplace, in urban environments, and on battlefields; exhaled air from medical patients; air in packaged food containers; and so forth can be accomplished with different types of analytical instruments. Vapor sensors have their niche in these measurements when an unobtrusive, low-power, and cost-sensitive technical solution is required. Unfortunately, existing vapor sensors often degrade their vapor-quantitation accuracy in the presence of high levels of interferences and cannot quantitate several components in complex gas mixtures. Thus, new sensing approaches with improved sensor selectivity are required. This technological task can be accomplished by the careful design of sensing materials with new performance properties and by coupling these materials with the suitable physical transducers. This review is focused on the assessment of the capabilities of bionanomaterials and bioinspired nanostructures for selective vapor sensing. We demonstrate that these sensing materials can operate with diverse transducers based on electrical, mechanical, and optical readout principles and can provide vapor-response selectivity previously unattainable by using other sensing materials. This ability for selective vapor sensing provides opportunities to significantly impact the major directions in development and application scenarios of vapor sensors.

An advanced application of the quantitative structure-activity relationship concept in electrokinetic chromatography of metal complexes.

PubMed

Oszwałdowski, Sławomir; Timerbaev, Andrei R

2008-02-01

The relevance of the quantitative structure-activity relationship (QSAR) principle in MEKC and microemulsion EKC (MEEKC) of metal-ligand complexes was evaluated for a better understanding of analyte migration mechanism. A series of gallium chelates were applied as test solutes with available experimental migration data in order to reveal the molecular properties that govern the separation. The QSAR models operating with n-octanol-water partition coefficients or van der Waals volumes were found to be valid for estimation of the retention factors (log k') of neutral compounds when using only an aqueous MEEKC electrolyte. On the other hand, consistent approximations of log k' for both uncharged and charged complexes in either EKC mode (and also with hydro-organic BGEs) were achievable with two-parametric QSARs in which the dipole moment is additionally incorporated as a structural descriptor, reflecting the electrostatic solute-pseudostationary phase interaction. The theoretical analysis of significant molecular parameters in MEKC systems, in which the micellar BGE is modified with an organic solvent, confirmed that concomitant consideration of hydrophobic, electrostatic, and solvation factors is essential for explaining the migration behavior of neutral metal complexes.

Monte Carlo modeling and optimization of buffer gas positron traps

NASA Astrophysics Data System (ADS)

Marjanović, Srđan; Petrović, Zoran Lj

2017-02-01

Buffer gas positron traps have been used for over two decades as the prime source of slow positrons enabling a wide range of experiments. While their performance has been well understood through empirical studies, no theoretical attempt has been made to quantitatively describe their operation. In this paper we apply standard models as developed for physics of low temperature collision dominated plasmas, or physics of swarms to model basic performance and principles of operation of gas filled positron traps. The Monte Carlo model is equipped with the best available set of cross sections that were mostly derived experimentally by using the same type of traps that are being studied. Our model represents in realistic geometry and fields the development of the positron ensemble from the initial beam provided by the solid neon moderator through voltage drops between the stages of the trap and through different pressures of the buffer gas. The first two stages employ excitation of N2 with acceleration of the order of 10 eV so that the trap operates under conditions when excitation of the nitrogen reduces the energy of the initial beam to trap the positrons without giving them a chance to become annihilated following positronium formation. The energy distribution function develops from the assumed distribution leaving the moderator, it is accelerated by the voltage drops and forms beams at several distinct energies. In final stages the low energy loss collisions (vibrational excitation of CF4 and rotational excitation of N2) control the approach of the distribution function to a Maxwellian at room temperature but multiple non-Maxwellian groups persist throughout most of the thermalization. Optimization of the efficiency of the trap may be achieved by changing the pressure and voltage drops and also by selecting to operate in a two stage mode. The model allows quantitative comparisons and test of optimization as well as development of other properties.

Distractor Inhibition: Principles of Operation during Selective Attention

ERIC Educational Resources Information Center

Wyatt, Natalie; Machado, Liana

2013-01-01

Research suggests that although target amplification acts as the main determinant of the efficacy of selective attention, distractor inhibition contributes under some circumstances. Here we aimed to gain insight into the operating principles that regulate the use of distractor inhibition during selective attention. The results suggest that, in…

75 FR 64728 - Cooperative Operating Philosophy-Serving the Members of Farm Credit System Institutions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... System (System) institutions are required to operate.\\1\\ The FCA emphasizes cooperative principles by... the management, control, and ownership of their institutions.\\2\\ The FCA also emphasizes cooperative principles in the examination function and Financial Institution Rating System (FIRS) used to categorize the...

An Informal Paper: Teaching the Profoundly Handicapped Child.

ERIC Educational Resources Information Center

Silverrain, Ann

The paper outlines the operative principles for understanding learning and discusses how these principles can help in planning a functional program for a severely or profoundly brain-damaged child. Discussed are: (1) the role of memory in learning; (2) simple associative learning (Pavlovian Conditioning and Operant Conditioning); (3) Piaget's…

Basic principles of variable speed drives

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.

1973-01-01

An understanding of the principles which govern variable speed drive operation is discussed for successful drive application. The fundamental factors of torque, speed ratio, and power as they relate to drive selection are discussed. The basic types of variable speed drives, their operating characteristics and their applications are also presented.

Endorsement of universal health coverage financial principles in Burkina Faso.

PubMed

Agier, Isabelle; Ly, Antarou; Kadio, Kadidiatou; Kouanda, Seni; Ridde, Valéry

2016-02-01

In West Africa, health system funding rarely involves cross-subsidization among population segments. In some countries, a few community-based or professional health insurance programs are present, but coverage is very low. The financial principles underlying universal health coverage (UHC) sustainability and solidarity are threefold: 1) anticipation of potential health risks; 2) risk sharing and; 3) socio-economic status solidarity. In Burkina Faso, where decision-makers are favorable to national health insurance, we measured endorsement of these principles and discerned which management configurations would achieve the greatest adherence. We used a sequential exploratory design. In a qualitative step (9 interviews, 12 focus groups), we adapted an instrument proposed by Goudge et al. (2012) to the local context and addressed desirability bias. Then, in a quantitative step (1255 respondents from the general population), we measured endorsement. Thematic analysis (qualitative) and logistic regressions (quantitative) were used. High levels of endorsement were found for each principle. Actual practices showed that anticipation and risk sharing were not only intentions. Preferences were given to solidarity between socio-economic status (SES) levels and progressivity. Although respondents seemed to prefer the national level for implementation, their current solidarity practices were mainly focused on close family. Thus, contribution levels should be set so that the entire family benefits from healthcare. Some critical conditions must be met to make UHC financial principles a reality through health insurance in Burkina Faso: trust, fair and mandatory contributions, and education. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Fully wireless pressure sensor based on endoscopy images

NASA Astrophysics Data System (ADS)

Maeda, Yusaku; Mori, Hirohito; Nakagawa, Tomoaki; Takao, Hidekuni

2018-04-01

In this paper, the result of developing a fully wireless pressure sensor based on endoscopy images for an endoscopic surgery is reported for the first time. The sensor device has structural color with a nm-scale narrow gap, and the gap is changed by air pressure. The structural color of the sensor is acquired from camera images. Pressure detection can be realized with existing endoscope configurations only. The inner air pressure of the human body should be measured under flexible-endoscope operation using the sensor. Air pressure monitoring, has two important purposes. The first is to quantitatively measure tumor size under a constant air pressure for treatment selection. The second purpose is to prevent the endangerment of a patient due to over transmission of air. The developed sensor was evaluated, and the detection principle based on only endoscopy images has been successfully demonstrated.

Changing the Paradigm: Simulation, a Method of First Resort

DTIC Science & Technology

2011-09-01

Environment xvii USAF United States Air Force USD(I) Under Secretary of Defense (Intelligence) V&V Verification and Validation VIC Vector -in...continued use throughout the operations research community, and is perhaps best known from Harvey Wagner’s seminal textbook Principles of Operations...pages 887 and 890 of Harvey Wagner’s seminal textbook Principles of Operations Research (Wagner, 1969). Why was this the paradigm of the time? Was

A supersonic fan equipped variable cycle engine for a Mach 2.7 supersonic transport

NASA Technical Reports Server (NTRS)

Tavares, T. S.

1985-01-01

The concept of a variable cycle turbofan engine with an axially supersonic fan stage as powerplant for a Mach 2.7 supersonic transport was evaluated. Quantitative cycle analysis was used to assess the effects of the fan inlet and blading efficiencies on engine performance. Thrust levels predicted by cycle analysis are shown to match the thrust requirements of a representative aircraft. Fan inlet geometry is discussed and it is shown that a fixed geometry conical spike will provide sufficient airflow throughout the operating regime. The supersonic fan considered consists of a single stage comprising a rotor and stator. The concept is similar in principle to a supersonic compressor, but differs by having a stator which removes swirl from the flow without producing a net rise in static pressure. Operating conditions peculiar to the axially supersonic fan are discussed. Geometry of rotor and stator cascades are presented which utilize a supersonic vortex flow distribution. Results of a 2-D CFD flow analysis of these cascades are presented. A simple estimate of passage losses was made using empirical methods.

Principles of cooperation across systems: from human sharing to multicellularity and cancer.

PubMed

Aktipis, Athena

2016-01-01

From cells to societies, several general principles arise again and again that facilitate cooperation and suppress conflict. In this study, I describe three general principles of cooperation and how they operate across systems including human sharing, cooperation in animal and insect societies and the massively large-scale cooperation that occurs in our multicellular bodies. The first principle is that of Walk Away: that cooperation is enhanced when individuals can leave uncooperative partners. The second principle is that resource sharing is often based on the need of the recipient (i.e., need-based transfers) rather than on strict account-keeping. And the last principle is that effective scaling up of cooperation requires increasingly sophisticated and costly cheater suppression mechanisms. By comparing how these principles operate across systems, we can better understand the constraints on cooperation. This can facilitate the discovery of novel ways to enhance cooperation and suppress cheating in its many forms, from social exploitation to cancer.

Implementation of utaut model to understand the use of virtual classroom principle in higher education

NASA Astrophysics Data System (ADS)

Aditya, B. R.; Permadi, A.

2018-03-01

This paper describes implementation of Unified Theory of Acceptance and User of Technology (UTAUT) model to assess the use of virtual classroom in support of teaching and learning in higher education. The purpose of this research is how virtual classroom that has fulfilled the basic principle can be accepted and used by students positively. This research methodology uses the quantitative and descriptive approach with a questionnaire as a tool for measuring the height of virtual classroom principle acception. This research uses a sample of 105 students in D3 Informatics Management at Telkom University. The result of this research is that the use of classroom virtual principle are positive and relevant to the students in higher education.

The redoubtable ecological periodic table

EPA Science Inventory

Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

Principles for the formation of an effective concept of multifunctional high-rise construction investment projects

NASA Astrophysics Data System (ADS)

Beliakov, Sergei

2018-03-01

Investment projects of high-rise construction have a number of features that determine specific risks and additional opportunities that require analysis and accounting in the formation of an effective project concept. The most significant features of high-rise construction include long construction time, complexity of technical and technological solutions, complexity of decisions on the organization of construction and operation, high cost of construction and operation, complexity in determining the ratio of areas designed to accommodate different functional areas, when organizing and coordinating the operation of the facility, with internal zoning. Taking into account the specificity of high-rise construction, among the factors determining the effectiveness of projects, it is advisable to consider as key factors: organizational, technological and investment factors. Within the framework of the article, the author singled out key particular functions for each group of factors under consideration, and also developed a system of principles for the formation of an effective concept of multifunctional high-rise construction investment projects, including the principle of logistic efficiency, the principle of optimal functional zoning, the principle of efficiency of equipment use, the principle of optimizing technological processes, the principle maximization of income, the principle of fund management, the principle of risk management . The model of formation of an effective concept of investment projects of multifunctional high-rise construction developed by the author can contribute to the development of methodological tools in the field of managing the implementation of high-rise construction projects, taking into account their specificity in the current economic conditions.

Coordinated Optimization of Visual Cortical Maps (I) Symmetry-based Analysis

PubMed Central

Reichl, Lars; Heide, Dominik; Löwel, Siegrid; Crowley, Justin C.; Kaschube, Matthias; Wolf, Fred

2012-01-01

In the primary visual cortex of primates and carnivores, functional architecture can be characterized by maps of various stimulus features such as orientation preference (OP), ocular dominance (OD), and spatial frequency. It is a long-standing question in theoretical neuroscience whether the observed maps should be interpreted as optima of a specific energy functional that summarizes the design principles of cortical functional architecture. A rigorous evaluation of this optimization hypothesis is particularly demanded by recent evidence that the functional architecture of orientation columns precisely follows species invariant quantitative laws. Because it would be desirable to infer the form of such an optimization principle from the biological data, the optimization approach to explain cortical functional architecture raises the following questions: i) What are the genuine ground states of candidate energy functionals and how can they be calculated with precision and rigor? ii) How do differences in candidate optimization principles impact on the predicted map structure and conversely what can be learned about a hypothetical underlying optimization principle from observations on map structure? iii) Is there a way to analyze the coordinated organization of cortical maps predicted by optimization principles in general? To answer these questions we developed a general dynamical systems approach to the combined optimization of visual cortical maps of OP and another scalar feature such as OD or spatial frequency preference. From basic symmetry assumptions we obtain a comprehensive phenomenological classification of possible inter-map coupling energies and examine representative examples. We show that each individual coupling energy leads to a different class of OP solutions with different correlations among the maps such that inferences about the optimization principle from map layout appear viable. We systematically assess whether quantitative laws resembling experimental observations can result from the coordinated optimization of orientation columns with other feature maps. PMID:23144599

Classroom Demonstrations of Polymer Principles.

ERIC Educational Resources Information Center

Rodriguez, F.

1990-01-01

Classroom demonstrations of selected mechanical properties of polymers are described that can be used to make quantitative measurements. Stiffness, strength, and extensibility are mechanical properties used to distinguish one polymer from another. (KR)

X-ray microprobe analysis of platelets. Principles, methods and review of the literature.

PubMed

Yarom, R

1983-01-01

Platelets are well suited to X-ray microanalysis as there is no need for chemical fixation or sectioning, and the concentrations of calcium and phosphorus are above 10(-3). The principles of the technique, the methods of specimen preparation, instrumental conditions during analysis and ways of quantitation are described. This is followed by a review of published reports and a brief summary of the author's own work in the field.

Differentiating malignant from benign breast tumors on acoustic radiation force impulse imaging using fuzzy-based neural networks with principle component analysis

NASA Astrophysics Data System (ADS)

Liu, Hsiao-Chuan; Chou, Yi-Hong; Tiu, Chui-Mei; Hsieh, Chi-Wen; Liu, Brent; Shung, K. Kirk

2017-03-01

Many modalities have been developed as screening tools for breast cancer. A new screening method called acoustic radiation force impulse (ARFI) imaging was created for distinguishing breast lesions based on localized tissue displacement. This displacement was quantitated by virtual touch tissue imaging (VTI). However, VTIs sometimes express reverse results to intensity information in clinical observation. In the study, a fuzzy-based neural network with principle component analysis (PCA) was proposed to differentiate texture patterns of malignant breast from benign tumors. Eighty VTIs were randomly retrospected. Thirty four patients were determined as BI-RADS category 2 or 3, and the rest of them were determined as BI-RADS category 4 or 5 by two leading radiologists. Morphological method and Boolean algebra were performed as the image preprocessing to acquire region of interests (ROIs) on VTIs. Twenty four quantitative parameters deriving from first-order statistics (FOS), fractal dimension and gray level co-occurrence matrix (GLCM) were utilized to analyze the texture pattern of breast tumors on VTIs. PCA was employed to reduce the dimension of features. Fuzzy-based neural network as a classifier to differentiate malignant from benign breast tumors. Independent samples test was used to examine the significance of the difference between benign and malignant breast tumors. The area Az under the receiver operator characteristic (ROC) curve, sensitivity, specificity and accuracy were calculated to evaluate the performance of the system. Most all of texture parameters present significant difference between malignant and benign tumors with p-value of less than 0.05 except the average of fractal dimension. For all features classified by fuzzy-based neural network, the sensitivity, specificity, accuracy and Az were 95.7%, 97.1%, 95% and 0.964, respectively. However, the sensitivity, specificity, accuracy and Az can be increased to 100%, 97.1%, 98.8% and 0.985, respectively if PCA was performed to reduce the dimension of features. Patterns of breast tumors on VTIs can effectively be recognized by quantitative texture parameters, and differentiated malignant from benign lesions by fuzzy-based neural network with PCA.

The Value of the Operational Principle in Instructional Design

ERIC Educational Resources Information Center

Gibbons, Andrew S.

2009-01-01

Formal design studies are increasing our insight into design processes, including those of instructional design. Lessons are being learned from other design fields, and new techniques and concepts can be imported as they are demonstrated effective. The purpose of this article is to introduce a design concept--the "operational principle"--for…

An Undergraduate Course on Operating Systems Principles.

ERIC Educational Resources Information Center

National Academy of Engineering, Washington, DC. Commission on Education.

This report is from Task Force VIII of the COSINE Committee of the Commission on Education of the National Academy of Engineering. The task force was established to formulate subject matter for an elective undergraduate subject on computer operating systems principles for students whose major interest is in the engineering of computer systems and…

[Operational costs and control of performance in surgical clinics between marketing and planning economics. Risk or perhaps quadrature of the circle].

PubMed

Kraus, T W; Weber, W; Mieth, M; Funk, H; Klar, E; Herfarth, C

2000-03-01

Surgical hospitals can be seen as operational or even industrial production systems. Doctors have a major impact on both medical performance and costs. For active participation in the management process, knowledge of industrial controlling mechanisms is required. German hospitals currently receive no procedure-related financial revenues, such as prices or tariffs for defined medical treatment activities. Maximum clinical revenues are, furthermore, limited by principles of planned economy and can be increased only slightly by greater medical performance. Costs are the only target that can be autonomously influenced by the management. Operative controlling in hospitals aims at horizontal and vertical coordination of subunits and decentralization of process regulations. Hospital medical performance is not clearly defined, its quantitative measurement very problematic. Process-orientated clinical activities are not taken into account. A high percentage of hospital costs are fixed and can be influenced only by major structural interventions in the long term. Variable costs are primarily dependent on the quantity of clinical activities, but also heavily influenced by patient structure (comorbidity and risk profile). The various forms of industrial cost calculations, such as internal budgeting, internal markets or flexible plan-cost balancing, cannot be directly applied in hospital management. Based on these analyses, current operational concepts and strategic trends are listed to describe cost-management options in hospitals with focus on the German health reforms.

A qualitative content analysis of global health engagements in Peacekeeping and Stability Operations Institute's stability operations lessons learned and information management system.

PubMed

Nang, Roberto N; Monahan, Felicia; Diehl, Glendon B; French, Daniel

2015-04-01

Many institutions collect reports in databases to make important lessons-learned available to their members. The Uniformed Services University of the Health Sciences collaborated with the Peacekeeping and Stability Operations Institute to conduct a descriptive and qualitative analysis of global health engagements (GHEs) contained in the Stability Operations Lessons Learned and Information Management System (SOLLIMS). This study used a summative qualitative content analysis approach involving six steps: (1) a comprehensive search; (2) two-stage reading and screening process to identify first-hand, health-related records; (3) qualitative and quantitative data analysis using MAXQDA, a software program; (4) a word cloud to illustrate word frequencies and interrelationships; (5) coding of individual themes and validation of the coding scheme; and (6) identification of relationships in the data and overarching lessons-learned. The individual codes with the most number of text segments coded included: planning, personnel, interorganizational coordination, communication/information sharing, and resources/supplies. When compared to the Department of Defense's (DoD's) evolving GHE principles and capabilities, the SOLLIMS coding scheme appeared to align well with the list of GHE capabilities developed by the Department of Defense Global Health Working Group. The results of this study will inform practitioners of global health and encourage additional qualitative analysis of other lessons-learned databases. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.

Capillary Two-Phase Thermal Devices for Space Applications

NASA Technical Reports Server (NTRS)

Ku, Jentung

2016-01-01

This is the presentation file for an invited seminar for Department of Mechanical and Aerospace Engineering at the Case Western Reserve University. The seminar is scheduled for April 1, 2016.Description: This presentation will discuss operating principles and performance characteristics of heat pipes (HPs) and loop heat pipes (LHPs) and their application for spacecraft thermal control. Topics include: 1) HP operating principles; 2) HP performance characteristics; 3) LHP pressure profiles; 4) LHP operating temperature; 5) LHP operating temperature control; and 6) Examples of using HPs and LHPs on NASA flight projects.

Department of Defense Information Enterprise Architecture Version 1.2

DTIC Science & Technology

2010-05-07

mission. Principles express an organization’s intentions so that design and investment decisions can be made from a common basis of understanding ... Business rules are definitive statements that constrain operations to implement the principle and associated policies. The vision, principles, and

Tapping into tongue motion to substitute or augment upper limbs

NASA Astrophysics Data System (ADS)

Ghovanloo, Maysam; Sahadat, M. Nazmus; Zhang, Zhenxuan; Kong, Fanpeng; Sebkhi, Nordine

2017-05-01

Assistive technologies (AT) play an important role in the lives of people with disabilities. Most importantly, they allow individuals with severe physical disabilities become more independence. Inherent abilities of the human tongue originated from its strong representation in the motor cortex, its direct connection to the brain through well-protected cranial nerves, and easy access without a surgery have resulted in development of a series of tongue-operated ATs that tap into the dexterous, intuitive, rapid, precise, and tireless motion of the tongue. These ATs not only help people with tetraplegia as a result of spinal cord injury or degenerative neurological diseases to access computers/smartphones, drive wheelchairs, and interact with their environments but also have the potential to enhance rehabilitation paradigms for stroke survivors. In this paper, various types of tongue operated ATs are discussed based on their working principles and task based performances. Comparisons are drawn based on widely accepted and standardized quantitative measures, such as throughput, information transfer rate, typing speed/accuracy, tracking error, navigation period, and navigation accuracy as well as qualitative measures, such as user feedback. Finally, the prospects of using variations of these versatile devices to enhance human performance in environments that limit hand and finger movements, such as space exploration or underwater operations are discussed.

MODELING OPERANT BEHAVIOR IN THE PARKINSONIAN RAT

PubMed Central

Avila, Irene; Reilly, Mark P.; Sanabria, Federico; Posadas-Sánchez, Diana; Chavez, Claudia L.; Banerjee, Nikhil; Killeen, Peter; Castañeda, Edward

2009-01-01

Mathematical principles of reinforcement (MPR; Killeen, 1994) is a quantitative model of operant behavior that contains 3 parameters representing motor capacity (δ), motivation (a), and short term memory (λ). The present study applied MPR to characterize the effects of bilateral infusions of 6-OHDA into the substantia nigra pars compacta in the rat, a model of Parkinson’s disease. Rats were trained to lever press under a 5-component fixed ratio (5, 15, 30, 60, and 100) schedule of food reinforcement. Rats were tested for 15 days prior to dopamine lesions and again for 15 days post-lesion. To characterize functional loss relative to lesion size, rats were grouped according to the extent and the degree of lateralization of their dopamine loss. Response rates decreased as a function of dopamine depletion, primarily at intermediate ratios. MPR accounted for 98% of variance in pre- and post-lesion response rates. Consistent with reported disruptions in motor behavior induced by dopaminergic lesions, estimates of δ increased when dopamine was severely depleted. There was no support for different estimates of a based on pre- and post-lesion performance of any lesion group, suggesting that dopamine loss has negligible effects on incentive motivation. The present study demonstrates the usefulness of combining operant techniques with a theoretical model to better understand the effects of a neurochemical manipulation. PMID:19073222

Nonperturbative quark, gluon, and meson correlators of unquenched QCD

NASA Astrophysics Data System (ADS)

Cyrol, Anton K.; Mitter, Mario; Pawlowski, Jan M.; Strodthoff, Nils

2018-03-01

We present nonperturbative first-principle results for quark, gluon, and meson 1PI correlation functions of two-flavor Landau-gauge QCD in the vacuum. These correlation functions carry the full information about the theory. They are obtained by solving their functional renormalization group equations in a systematic vertex expansion, aiming at apparent convergence. This work represents a crucial prerequisite for quantitative first-principle studies of the QCD phase diagram and the hadron spectrum within this framework. In particular, we have computed the gluon, ghost, quark, and scalar-pseudoscalar meson propagators, as well as gluon, ghost-gluon, quark-gluon, quark, quark-meson, and meson interactions. Our results stress the crucial importance of the quantitatively correct running of different vertices in the semiperturbative regime for describing the phenomena and scales of confinement and spontaneous chiral symmetry breaking without phenomenological input.

Does team training work? Principles for health care.

PubMed

Salas, Eduardo; DiazGranados, Deborah; Weaver, Sallie J; King, Heidi

2008-11-01

Teamwork is integral to a working environment conducive to patient safety and care. Team training is one methodology designed to equip team members with the competencies necessary for optimizing teamwork. There is evidence of team training's effectiveness in highly complex and dynamic work environments, such as aviation and health care. However, most quantitative evaluations of training do not offer any insight into the actual reasons why, how, and when team training is effective. To address this gap in understanding, and to provide guidance for members of the health care community interested in implementing team training programs, this article presents both quantitative results and a specific qualitative review and content analysis of team training implemented in health care. Based on this review, we offer eight evidence-based principles for effective planning, implementation, and evaluation of team training programs specific to health care.

Modified Universal Design Survey: Enhancing Operability of Launch Vehicle Ground Crew Worksites

NASA Technical Reports Server (NTRS)

Blume, Jennifer L.

2010-01-01

Operability is a driving requirement for next generation space launch vehicles. Launch site ground operations include numerous operator tasks to prepare the vehicle for launch or to perform preflight maintenance. Ensuring that components requiring operator interaction at the launch site are designed for optimal human use is a high priority for operability. To promote operability, a Design Quality Evaluation Survey based on Universal Design framework was developed to support Human Factors Engineering (HFE) evaluation for NASA s launch vehicles. Universal Design per se is not a priority for launch vehicle processing however; applying principles of Universal Design will increase the probability of an error free and efficient design which promotes operability. The Design Quality Evaluation Survey incorporates and tailors the seven Universal Design Principles and adds new measures for Safety and Efficiency. Adapting an approach proven to measure Universal Design Performance in Product, each principle is associated with multiple performance measures which are rated with the degree to which the statement is true. The Design Quality Evaluation Survey was employed for several launch vehicle ground processing worksite analyses. The tool was found to be most useful for comparative judgments as opposed to an assessment of a single design option. It provided a useful piece of additional data when assessing possible operator interfaces or worksites for operability.

Agile: From Software to Mission Systems

NASA Technical Reports Server (NTRS)

Trimble, Jay; Shirley, Mark; Hobart, Sarah

2017-01-01

To maximize efficiency and flexibility in Mission Operations System (MOS) design, we are evolving principles from agile and lean methods for software, to the complete mission system. This allows for reduced operational risk at reduced cost, and achieves a more effective design through early integration of operations into mission system engineering and flight system design. The core principles are assessment of capability through demonstration, risk reduction through targeted experiments, early test and deployment, and maturation of processes and tools through use.

The Operating Principle of a Fully Solid State Active Magnetic Regenerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdelaziz, Omar

As an alternative refrigeration technology, magnetocaloric refrigeration has the potential to be safer, quieter, more efficient, and more environmentally friendly than the conventional vapor compression refrigeration technology. Most of the reported active magnetic regenerator (AMR) systems that operate based on the magnetocaloric effect use heat transfer fluid to exchange heat, which results in complicated mechanical subsystems and components such as rotating valves and hydraulic pumps. This paper presents an operating principle of a fully solid state AMR, in which an alternative mechanism for heat transfer between the AMR and the heat source/sink is proposed. The operating principle of the fullymore » solid state AMR is based on moving rods/sheets (e.g. copper, brass, iron or aluminum), which are employed to replace the heat transfer fluid. Such fully solid state AMR would provide a significantly higher heat transfer rate than a conventional AMR because the conductivity of moving solid rods/plates is high and it enables the increase in the machine operating frequency hence the cooling capacity. The details of operating principle are presented and discussed here. One of the key enabling features for this technology is the contact between the moving rods/sheets and magnetocaloric material, and heat exchange mechanism at the heat source/sink. This paper provides an overview of the design for a fully solid state magnetocaloric refrigeration system along with guidelines for their optimal design.« less

Analysis of Operating Principles with S-system Models

PubMed Central

Lee, Yun; Chen, Po-Wei; Voit, Eberhard O.

2011-01-01

Operating principles address general questions regarding the response dynamics of biological systems as we observe or hypothesize them, in comparison to a priori equally valid alternatives. In analogy to design principles, the question arises: Why are some operating strategies encountered more frequently than others and in what sense might they be superior? It is at this point impossible to study operation principles in complete generality, but the work here discusses the important situation where a biological system must shift operation from its normal steady state to a new steady state. This situation is quite common and includes many stress responses. We present two distinct methods for determining different solutions to this task of achieving a new target steady state. Both methods utilize the property of S-system models within Biochemical Systems Theory (BST) that steady-states can be explicitly represented as systems of linear algebraic equations. The first method uses matrix inversion, a pseudo-inverse, or regression to characterize the entire admissible solution space. Operations on the basis of the solution space permit modest alterations of the transients toward the target steady state. The second method uses standard or mixed integer linear programming to determine admissible solutions that satisfy criteria of functional effectiveness, which are specified beforehand. As an illustration, we use both methods to characterize alternative response patterns of yeast subjected to heat stress, and compare them with observations from the literature. PMID:21377479

Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging.

PubMed

Jung, Jae-Hwang; Jang, Jaeduck; Park, Yongkeun

2013-11-05

We present a novel spectroscopic quantitative phase imaging technique with a wavelength swept-source, referred to as swept-source diffraction phase microscopy (ssDPM), for quantifying the optical dispersion of microscopic individual samples. Employing the swept-source and the principle of common-path interferometry, ssDPM measures the multispectral full-field quantitative phase imaging and spectroscopic microrefractometry of transparent microscopic samples in the visible spectrum with a wavelength range of 450-750 nm and a spectral resolution of less than 8 nm. With unprecedented precision and sensitivity, we demonstrate the quantitative spectroscopic microrefractometry of individual polystyrene beads, 30% bovine serum albumin solution, and healthy human red blood cells.

Optical Fiber Sensors for Advanced Civil Structures

NASA Astrophysics Data System (ADS)

de Vries, Marten Johannes Cornelius

1995-01-01

The objective of this dissertation is to develop, analyze, and implement optical fiber-based sensors for the nondestructive quantitative evaluation of advanced civil structures. Based on a comparative evaluation of optical fiber sensors that may be used to obtain quantitative information related to physical perturbations in the civil structure, the extrinsic Fabry-Perot interferometric (EFPI) optical fiber sensor is selected as the most attractive sensor. The operation of the EFPI sensor is explained using the Kirchhoff diffraction approach. As is shown in this dissertation, this approach better predicts the signal-to-noise ratio as a function of gap length than methods employed previously. The performance of the optical fiber sensor is demonstrated in three different implementations. In the first implementation, performed with researchers in the Civil Engineering Department at the University of Southern California in Los Angeles, optical fiber sensors were used to obtain quantitative strain information from reinforced concrete interior and exterior column-to-beam connections. The second implementation, performed in cooperation with researchers at the United States Bureau of Mines in Spokane, Washington, used optical fiber sensors to monitor the performance of roof bolts used in mines. The last implementation, performed in cooperation with researchers at the Turner-Fairbanks Federal Highway Administration Research Center in McLean, Virginia, used optical fiber sensors, attached to composite prestressing strands used for reinforcing concrete, to obtain absolute strain information. Multiplexing techniques including time, frequency and wavelength division multiplexing are briefly discussed, whereas the principles of operation of spread spectrum and optical time domain reflectometery (OTDR) are discussed in greater detail. Results demonstrating that spread spectrum and OTDR techniques can be used to multiplex optical fiber sensors are presented. Finally, practical considerations that have to be taken into account when implementing optical fiber sensors into a civil structure environment are discussed, and possible solutions to some of these problems are proposed.

Fiber optic sensor for measurement of pressure fluctuations at high temperatures

NASA Technical Reports Server (NTRS)

Zuckerwar, Allan J.; Cuomo, Frank W.

1989-01-01

A fiber-optic sensor, based on the principle of the fiber-optic lever, is described which features small size, extended bandwidth, and capability to operate at high temeratures, as required for measurements in hypersonic flow. The principle of operation, design features peculiar to the intended application, and expected performance at high temperatures are described.

ON THE STRONG EXTREMUM PRINCIPLE FOR A \\mathrm{D}-(\\Pi, \\Omega)-ELLIPTICALLY CONNECTED OPERATOR OF SECOND ORDER

NASA Astrophysics Data System (ADS)

Kamynin, L. I.; Himčenko, B. N.

1981-02-01

In this paper the strong extremum principle is proved for a certain new class of second order operators with nonnegative characteristic form, without requiring the smoothness of their coefficients, which is essential in the converse of Raševskiĭ's theorem on completely nonholonomic systems. Bibliography: 19 titles.

Leverage principle of retardation signal in titration of double protein via chip moving reaction boundary electrophoresis.

PubMed

Zhang, Liu-Xia; Cao, Yi-Ren; Xiao, Hua; Liu, Xiao-Ping; Liu, Shao-Rong; Meng, Qing-Hua; Fan, Liu-Yin; Cao, Cheng-Xi

2016-03-15

In the present work we address a simple, rapid and quantitative analytical method for detection of different proteins present in biological samples. For this, we proposed the model of titration of double protein (TDP) and its relevant leverage theory relied on the retardation signal of chip moving reaction boundary electrophoresis (MRBE). The leverage principle showed that the product of the first protein content and its absolute retardation signal is equal to that of the second protein content and its absolute one. To manifest the model, we achieved theoretical self-evidence for the demonstration of the leverage principle at first. Then relevant experiments were conducted on the TDP-MRBE chip. The results revealed that (i) there was a leverage principle of retardation signal within the TDP of two pure proteins, and (ii) a lever also existed within these two complex protein samples, evidently demonstrating the validity of TDP model and leverage theory in MRBE chip. It was also showed that the proposed technique could provide a rapid and simple quantitative analysis of two protein samples in a mixture. Finally, we successfully applied the developed technique for the quantification of soymilk in adulterated infant formula. The TDP-MRBE opens up a new window for the detection of adulteration ratio of the poor food (milk) in blended high quality one. Copyright © 2015 Elsevier B.V. All rights reserved.

32 CFR 634.26 - Traffic law enforcement principles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Traffic law enforcement principles. 634.26... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.26 Traffic law enforcement principles. (a) Traffic law enforcement should motivate drivers to operate vehicles...

32 CFR 634.26 - Traffic law enforcement principles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Traffic law enforcement principles. 634.26... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.26 Traffic law enforcement principles. (a) Traffic law enforcement should motivate drivers to operate vehicles...

Quantitative dispersion microscopy

PubMed Central

Fu, Dan; Choi, Wonshik; Sung, Yongjin; Yaqoob, Zahid; Dasari, Ramachandra R.; Feld, Michael

2010-01-01

Refractive index dispersion is an intrinsic optical property and a useful source of contrast in biological imaging studies. In this report, we present the first dispersion phase imaging of living eukaryotic cells. We have developed quantitative dispersion microscopy based on the principle of quantitative phase microscopy. The dual-wavelength quantitative phase microscope makes phase measurements at 310 nm and 400 nm wavelengths to quantify dispersion (refractive index increment ratio) of live cells. The measured dispersion of living HeLa cells is found to be around 1.088, which agrees well with that measured directly for protein solutions using total internal reflection. This technique, together with the dry mass and morphology measurements provided by quantitative phase microscopy, could prove to be a useful tool for distinguishing different types of biomaterials and studying spatial inhomogeneities of biological samples. PMID:21113234

Critical and maximally informative encoding between neural populations in the retina

PubMed Central

Kastner, David B.; Baccus, Stephen A.; Sharpee, Tatyana O.

2015-01-01

Computation in the brain involves multiple types of neurons, yet the organizing principles for how these neurons work together remain unclear. Information theory has offered explanations for how different types of neurons can maximize the transmitted information by encoding different stimulus features. However, recent experiments indicate that separate neuronal types exist that encode the same filtered version of the stimulus, but then the different cell types signal the presence of that stimulus feature with different thresholds. Here we show that the emergence of these neuronal types can be quantitatively described by the theory of transitions between different phases of matter. The two key parameters that control the separation of neurons into subclasses are the mean and standard deviation (SD) of noise affecting neural responses. The average noise across the neural population plays the role of temperature in the classic theory of phase transitions, whereas the SD is equivalent to pressure or magnetic field, in the case of liquid–gas and magnetic transitions, respectively. Our results account for properties of two recently discovered types of salamander Off retinal ganglion cells, as well as the absence of multiple types of On cells. We further show that, across visual stimulus contrasts, retinal circuits continued to operate near the critical point whose quantitative characteristics matched those expected near a liquid–gas critical point and described by the nearest-neighbor Ising model in three dimensions. By operating near a critical point, neural circuits can maximize information transmission in a given environment while retaining the ability to quickly adapt to a new environment. PMID:25675497

Quantitative Visualization of Salt Concentration Distributions in Lithium-Ion Battery Electrolytes during Battery Operation Using X-ray Phase Imaging.

PubMed

Takamatsu, Daiko; Yoneyama, Akio; Asari, Yusuke; Hirano, Tatsumi

2018-02-07

A fundamental understanding of concentrations of salts in lithium-ion battery electrolytes during battery operation is important for optimal operation and design of lithium-ion batteries. However, there are few techniques that can be used to quantitatively characterize salt concentration distributions in the electrolytes during battery operation. In this paper, we demonstrate that in operando X-ray phase imaging can quantitatively visualize the salt concentration distributions that arise in electrolytes during battery operation. From quantitative evaluation of the concentration distributions at steady states, we obtained the salt diffusivities in electrolytes with different initial salt concentrations. Because of no restriction on samples and high temporal and spatial resolutions, X-ray phase imaging will be a versatile technique for evaluating electrolytes, both aqueous and nonaqueous, of many electrochemical systems.

Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study.

PubMed

Hruska, Carrie B; Geske, Jennifer R; Swanson, Tiffinee N; Mammel, Alyssa N; Lake, David S; Manduca, Armando; Conners, Amy Lynn; Whaley, Dana H; Scott, Christopher G; Carter, Rickey E; Rhodes, Deborah J; O'Connor, Michael K; Vachon, Celine M

2018-06-05

Background parenchymal uptake (BPU), which refers to the level of Tc-99m sestamibi uptake within normal fibroglandular tissue on molecular breast imaging (MBI), has been identified as a breast cancer risk factor, independent of mammographic density. Prior analyses have used subjective categories to describe BPU. We evaluate a new quantitative method for assessing BPU by testing its reproducibility, comparing quantitative results with previously established subjective BPU categories, and determining the association of quantitative BPU with breast cancer risk. Two nonradiologist operators independently performed region-of-interest analysis on MBI images viewed in conjunction with corresponding digital mammograms. Quantitative BPU was defined as a unitless ratio of the average pixel intensity (counts/pixel) within the fibroglandular tissue versus the average pixel intensity in fat. Operator agreement and the correlation of quantitative BPU measures with subjective BPU categories assessed by expert radiologists were determined. Percent density on mammograms was estimated using Cumulus. The association of quantitative BPU with breast cancer (per one unit BPU) was examined within an established case-control study of 62 incident breast cancer cases and 177 matched controls. Quantitative BPU ranged from 0.4 to 3.2 across all subjects and was on average higher in cases compared to controls (1.4 versus 1.2, p < 0.007 for both operators). Quantitative BPU was strongly correlated with subjective BPU categories (Spearman's r = 0.59 to 0.69, p < 0.0001, for each paired combination of two operators and two radiologists). Interoperator and intraoperator agreement in the quantitative BPU measure, assessed by intraclass correlation, was 0.92 and 0.98, respectively. Quantitative BPU measures showed either no correlation or weak negative correlation with mammographic percent density. In a model adjusted for body mass index and percent density, higher quantitative BPU was associated with increased risk of breast cancer for both operators (OR = 4.0, 95% confidence interval (CI) 1.6-10.1, and 2.4, 95% CI 1.2-4.7). Quantitative measurement of BPU, defined as the ratio of average counts in fibroglandular tissue relative to that in fat, can be reliably performed by nonradiologist operators with a simple region-of-interest analysis tool. Similar to results obtained with subjective BPU categories, quantitative BPU is a functional imaging biomarker of breast cancer risk, independent of mammographic density and hormonal factors.

The positive impact of structured teaching in the operating room.

PubMed

Leung, Yee; Salfinger, Stuart; Mercer, Annette

2015-12-01

A survey of obstetric and gynaecology trainees in Australia found the trainee's opinion of the consultants' teaching ability for laparoscopic procedures and procedures dealing with complications as 'poor' in 21.2% and 23.4% of responses, respectively (Aust NZ J Obstet Gynaecol 2009; 49: 84). Surgical caseload per trainee is falling for a variety of reasons. Strategies need to be adopted to enhance the surgical learning experience of trainees in the operating room. We describe the use of a structured encounter template to facilitate the teaching of surgery in the operating room and report the response of the trainees to this intervention. Trainees attached to a gynaecologic surgery unit all underwent surgical training using a set format based on the surgical encounter template, including briefing, goal setting and intra-operative teaching aims as well as debriefing. Data on the trainees' experience and perception of their learning experience were then collected and analysed as quantitative and qualitative data sets. The trainees reported satisfaction with the use of a structured encounter template to facilitate the surgical teaching in the operating room. Some trainees had not received such clarity of feedback or the opportunity to complete a procedure independently prior to using the structured encounter template. A structured surgical encounter template based on andragogy principles to focus consultant teaching in the operating room is highly acceptable to obstetric and gynaecology trainees in Australia. Allowing the trainee the opportunity to set objectives and receive feedback empowers the trainee and enhances their educational experience. © 2015 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

Truck driver fatigue risk assessment and management: a multinational survey.

PubMed

Adams-Guppy, Julie; Guppy, Andrew

2003-06-20

As part of an organizational review of safety, interviews and questionnaire surveys were performed on over 700 commercial goods drivers and their managers within a series of related companies operating across 17 countries. The results examine the reported incidence of fatigue-related problems in drivers and their associations with near miss and accident experience as well as work and organizational factors. Experience of fatigue problems while driving was linked to time of day and rotation of shifts, though most associations were small. There were significant associations found between fatigue experiences and driver and management systems of break taking and route scheduling. The quantitative combined with qualitative information suggested that, where feasible, more flexible approaches to managing the scheduling and sequencing of deliveries assisted drivers in managing their own fatigue problems through appropriate break-taking. The results are interpreted within the overarching principles of risk assessment and risk control.

Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors.

PubMed

Mannan, Ahmad A; Liu, Di; Zhang, Fuzhong; Oyarzún, Diego A

2017-10-20

Metabolite biosensors are central to current efforts toward precision engineering of metabolism. Although most research has focused on building new biosensors, their tunability remains poorly understood and is fundamental for their broad applicability. Here we asked how genetic modifications shape the dose-response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we built promoter libraries with variable operator sites that reveal interdependencies between biosensor dynamic range and response threshold. We developed a phenomenological theory to quantify such design constraints in biosensors with various architectures and tunable parameters. Our theory reveals a maximal achievable dynamic range and exposes tunable parameters for orthogonal control of dynamic range and response threshold. Our work sheds light on fundamental limits of synthetic biology designs and provides quantitative guidelines for biosensor design in applications such as dynamic pathway control, strain optimization, and real-time monitoring of metabolism.

Positron emission tomography in cardiology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Correia, J.A.; Alpert, N.M.

1985-12-01

This article reviews the basis of PET imaging and current applications to cardiology. Included is a discussion of physical principles, detectors, quantitative estimation of regional radioactivity concentrations, radiopharmaceuticals, and application to flow and metabolism measurements in the myocardium.

Unassailable Advantage: The British Use of Principles of Joint Operations from 1758-1762

DTIC Science & Technology

2017-05-25

operations are based on the Principles of War developed by Baron Antoine Henri de Jomini. The Art of War (London: Greenhill Books), 1992. 6 JP 3-0, Joint...appointment based on this ability and willingness, rather than seniority.46 Also, the landing boats for the Rochefort operation were unacceptable. The... equipped with rudders and small sails to increase control and speed.47 They had either 16 or 20 oarsmen and could carry about a half a company of

Time Projection Compton Spectrometer (TPCS). User`s guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landron, C.O.; Baldwin, G.T.

1994-04-01

The Time Projection Compton Spectrometer (TPCS) is a radiation diagnostic designed to determine the time-integrated energy spectrum between 100 keV -- 2 MeV of flash x-ray sources. This guide is intended as a reference for the routine operator of the TPCS. Contents include a brief overview of the principle of operation, detailed component descriptions, detailed assembly and disassembly procedures, guide to routine operations, and troubleshooting flowcharts. Detailed principle of operation, signal analysis and spectrum unfold algorithms are beyond the scope of this guide; however, the guide makes reference to sources containing this information.

Distinguishing nanomaterial particles from background airborne particulate matter for quantitative exposure assessment

NASA Astrophysics Data System (ADS)

Ono-Ogasawara, Mariko; Serita, Fumio; Takaya, Mitsutoshi

2009-10-01

As the production of engineered nanomaterials quantitatively expands, the chance that workers involved in the manufacturing process will be exposed to nanoparticles also increases. A risk management system is needed for workplaces in the nanomaterial industry based on the precautionary principle. One of the problems in the risk management system is difficulty of exposure assessment. In this article, examples of exposure assessment in nanomaterial industries are reviewed with a focus on distinguishing engineered nanomaterial particles from background nanoparticles in workplace atmosphere. An approach by JNIOSH (Japan National Institute of Occupational Safety and Health) to quantitatively measure exposure to carbonaceous nanomaterials is also introduced. In addition to real-time measurements and qualitative analysis by electron microscopy, quantitative chemical analysis is necessary for quantitatively assessing exposure to nanomaterials. Chemical analysis is suitable for quantitative exposure measurement especially at facilities with high levels of background NPs.

12 CFR 270.3 - Governing principles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Governing principles. 270.3 Section 270.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE OPEN MARKET OPERATIONS OF... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume...

Beyond Training: New Ideas for Military Forces Operating beyond War

ERIC Educational Resources Information Center

Cornell-d'Echert, Blaise, Jr.

2012-01-01

Most adult education practitioners will understand the special requirements educators should attend to when educating adults. While Malcolm Knowles's adult education principles might not meet the strictest definition of principles, their universal adoption and acceptance by adult educators affords them the same weight as principles. So, as Knowles…

77 FR 64890 - Transmission Planning and Cost Allocation by Transmission Owning and Operating Public Utilities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... each cost allocation method must satisfy six cost allocation principles. DATES: Effective November 23... Interregional Transmission 61 Coordination Requirements III. Cost Allocation 65 1. Cost Allocation Principle 2... must satisfy six cost allocation principles. 3. In Order No. 1000-A, the Commission largely affirmed...

The Aristotelian Principle and Education.

ERIC Educational Resources Information Center

Pekarsky, Daniel

1980-01-01

For the Aristotelian principle to become operative, certain principles must be met. Individuals should be free from anxiety about satisfying basic needs. They cannot enjoy complexity in their lives beyond a certain point. To have satisfying lives, individuals should engage in both passive and active enjoyments, leading from a lower to a higher…

A liquid chromatography–tandem mass spectrometric method for quantitative determination of native 5-methyltetrahydrofolate and its polyglutamyl derivatives in raw vegetables

PubMed Central

Wang, Chao; Riedl, Ken M.; Schwartz, Steven J.

2013-01-01

Folate deficiency is a prevalent phenomenon worldwide especially in underprivileged countries. Polyglutamyl 5-methyltetrahydrofolate (5MTHF) species are the naturally occurring principle folate in store-bought vegetables. Here we report a simple and complete extraction method for the determination of native polyglutamyl 5-methyltetrahydrofolate in vegetables using high performance liquid chromatography with tandem mass spectrometric detection (HPLC–MS/MS). Coarsely chopped samples (18 different vegetables) were steamed to inactivate glutamylase enzymes and liberate folate from binding proteins and extracted in a reducing buffer with 13C5 5MTHF stable isotope added as internal standard. The polyglutamyl 5-methyltetrahydrofolate species were separated in 9 min on a C18 column using a reversed phase system. HPLC eluate was interfaced with a triple quadrupole mass spectrometer operated in electrospray positive mode. The respective pseudomolecular cation of each polyglutamyl 5-methyltetrahydrofolate species was selected for fragmentation to a common daughter ion for detection. We quantitated polyglutamyl 5-methyltetrahydrofolate in store-bought vegetables from families Brassicaceae, Asteraceae and Amaranthaceae (including mustard greens, romaine lettuce and Swiss chard) of which most have not been quantitated previously. Most vegetables from Asteraceae and those from Amaranthaceae contained similar amounts of monoglutamyl 5MTHF and polyglutamyl 5MTHF while Brassicaceae were dominated by polyglutamyls and endive species (Asteraceae) contained mainly monoglutamyl 5MTHF. The precision of the method for the various polyglutamyl 5-methyltetrahydrofolate forms was 1–9% RSD, recovery 84–91%, limit of detection 64–658 fmol and limit of quantitation 193–1994 fmol. Herein we describe a rapid, sensitive and selective HPLC–MS/MS technique to quantitate polyglutamyl 5-methyltetrahydrofolate species. This method may be suitable for analyzing the polyglutamyl 5-methyltetrahydrofolate profile of inherent folates in a wide range of leafy green vegetables. PMID:20888309

Kepler: Analogies in the search for the law of refraction.

PubMed

Cardona, Carlos Alberto

2016-10-01

This paper examines the methodology used by Kepler to discover a quantitative law of refraction. The aim is to argue that this methodology follows a heuristic method based on the following two Pythagorean principles: (1) sameness is made known by sameness, and (2) harmony arises from establishing a limit to what is unlimited. We will analyse some of the author's proposed analogies to find the aforementioned law and argue that the investigation's heuristic pursues such principles. Copyright © 2016 Elsevier Ltd. All rights reserved.

Endobiogeny: a global approach to systems biology (part 1 of 2).

PubMed

Lapraz, Jean-Claude; Hedayat, Kamyar M

2013-01-01

Endobiogeny is a global systems approach to human biology that may offer an advancement in clinical medicine based in scientific principles of rigor and experimentation and the humanistic principles of individualization of care and alleviation of suffering with minimization of harm. Endobiogeny is neither a movement away from modern science nor an uncritical embracing of pre-rational methods of inquiry but a synthesis of quantitative and qualitative relationships reflected in a systems-approach to life and based on new mathematical paradigms of pattern recognition.

The research of statistical properties of colorimetric features of screens with a three-component color formation principle

NASA Astrophysics Data System (ADS)

Zharinov, I. O.; Zharinov, O. O.

2017-12-01

The problem of the research is concerned with quantitative analysis of influence of technological variation of the screen color profile parameters on chromaticity coordinates of the displayed image. Some mathematical expressions which approximate the two-dimensional distribution of chromaticity coordinates of an image, which is displayed on the screen with a three-component color formation principle were proposed. Proposed mathematical expressions show the way to development of correction techniques to improve reproducibility of the colorimetric features of displays.

Electronic structure and microscopic model of CoNb2O6

NASA Astrophysics Data System (ADS)

Molla, Kaimujjaman; Rahaman, Badiur

2018-05-01

We present the first principle density functional calculations to figure out the underlying spin model of CoNb2O6. The first principles calculations define the main paths of superexchange interaction between Co spins in this compound. We discuss the nature of the exchange paths and provide quantitative estimates of magnetic exchange couplings. A microscopic modeling based on analysis of the electronic structure of this system puts it in the interesting class of weakly couple geometrically frustrated isosceles triangular Ising antiferromagnet.

Incorporation of Consumer Products in the Teaching of Analytical Chemistry.

ERIC Educational Resources Information Center

Lieu, Van T.; Kalbus, Gene E.

1988-01-01

Describes eight experiments involving the use of common consumer products that could be incorporated into quantitative and instrumental analysis laboratories. Discusses these activities in terms of illustration of principles, awareness, and critical thinking. (CW)

Vegetation structure from quantitative fusion of hyperspectral optical and radar interferometric remote sensing

NASA Technical Reports Server (NTRS)

Asner, G. P.; Treuhaft, R. N.; Law, B. E.

2000-01-01

One of today's principle objecdtives of remote sensing is carbon accounting in the world's forests via biomass monitoring. Determining carbon sequestration by forest ecosystems requires understanding the carbon budgets of these ecosystems.

Playful Physics

NASA Technical Reports Server (NTRS)

Weaver, David

2008-01-01

Effectively communicate qualitative and quantitative information orally and in writing. Explain the application of fundamental physical principles to various physical phenomena. Apply appropriate problem-solving techniques to practical and meaningful problems using graphical, mathematical, and written modeling tools. Work effectively in collaborative groups.

Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling

PubMed Central

Shin, Young Shik; Remacle, F.; Fan, Rong; Hwang, Kiwook; Wei, Wei; Ahmad, Habib; Levine, R.D.; Heath, James R.

2011-01-01

Protein signaling networks among cells play critical roles in a host of pathophysiological processes, from inflammation to tumorigenesis. We report on an approach that integrates microfluidic cell handling, in situ protein secretion profiling, and information theory to determine an extracellular protein-signaling network and the role of perturbations. We assayed 12 proteins secreted from human macrophages that were subjected to lipopolysaccharide challenge, which emulates the macrophage-based innate immune responses against Gram-negative bacteria. We characterize the fluctuations in protein secretion of single cells, and of small cell colonies (n = 2, 3,···), as a function of colony size. Measuring the fluctuations permits a validation of the conditions required for the application of a quantitative version of the Le Chatelier's principle, as derived using information theory. This principle provides a quantitative prediction of the role of perturbations and allows a characterization of a protein-protein interaction network. PMID:21575571

First-Principles Momentum-Dependent Local Ansatz Wavefunction and Momentum Distribution Function Bands of Iron

NASA Astrophysics Data System (ADS)

Kakehashi, Yoshiro; Chandra, Sumal

2016-04-01

We have developed a first-principles local ansatz wavefunction approach with momentum-dependent variational parameters on the basis of the tight-binding LDA+U Hamiltonian. The theory goes beyond the first-principles Gutzwiller approach and quantitatively describes correlated electron systems. Using the theory, we find that the momentum distribution function (MDF) bands of paramagnetic bcc Fe along high-symmetry lines show a large deviation from the Fermi-Dirac function for the d electrons with eg symmetry and yield the momentum-dependent mass enhancement factors. The calculated average mass enhancement m*/m = 1.65 is consistent with low-temperature specific heat data as well as recent angle-resolved photoemission spectroscopy (ARPES) data.

Deep Learning for Magnetic Resonance Fingerprinting: A New Approach for Predicting Quantitative Parameter Values from Time Series.

PubMed

Hoppe, Elisabeth; Körzdörfer, Gregor; Würfl, Tobias; Wetzl, Jens; Lugauer, Felix; Pfeuffer, Josef; Maier, Andreas

2017-01-01

The purpose of this work is to evaluate methods from deep learning for application to Magnetic Resonance Fingerprinting (MRF). MRF is a recently proposed measurement technique for generating quantitative parameter maps. In MRF a non-steady state signal is generated by a pseudo-random excitation pattern. A comparison of the measured signal in each voxel with the physical model yields quantitative parameter maps. Currently, the comparison is done by matching a dictionary of simulated signals to the acquired signals. To accelerate the computation of quantitative maps we train a Convolutional Neural Network (CNN) on simulated dictionary data. As a proof of principle we show that the neural network implicitly encodes the dictionary and can replace the matching process.

Statistical design of quantitative mass spectrometry-based proteomic experiments.

PubMed

Oberg, Ann L; Vitek, Olga

2009-05-01

We review the fundamental principles of statistical experimental design, and their application to quantitative mass spectrometry-based proteomics. We focus on class comparison using Analysis of Variance (ANOVA), and discuss how randomization, replication and blocking help avoid systematic biases due to the experimental procedure, and help optimize our ability to detect true quantitative changes between groups. We also discuss the issues of pooling multiple biological specimens for a single mass analysis, and calculation of the number of replicates in a future study. When applicable, we emphasize the parallels between designing quantitative proteomic experiments and experiments with gene expression microarrays, and give examples from that area of research. We illustrate the discussion using theoretical considerations, and using real-data examples of profiling of disease.

Coupling of conservative and dissipative forces in frequency-modulation atomic force microscopy

NASA Astrophysics Data System (ADS)

Sader, John E.; Jarvis, Suzanne P.

2006-11-01

Frequency modulation atomic force microscopy (FM-AFM) utilizes the principle of self-excitation to ensure the cantilever probe vibrates at its resonant frequency, regardless of the tip-sample interaction. Practically, this is achieved by fixing the phase difference between tip deflection and driving force at precisely 90° . This, in turn, decouples the frequency shift and excitation amplitude signals, enabling quantitative interpretation in terms of conservative and dissipative tip-sample interaction forces. In this article, we theoretically investigate the effect of phase detuning in the self-excitation mechanism on the coupling between conservative and dissipative forces in FM-AFM. We find that this coupling depends only on the relative difference in the drive and resonant frequencies far from the surface, and is thus very weakly dependent on the actual phase error particularly for high quality factors. This establishes that FM-AFM is highly robust with respect to phase detuning, and enables quantitative interpretation of the measured frequency shift and excitation amplitude, even while operating away from the resonant frequency with the use of appropriate replacements in the existing formalism. We also examine the calibration of phase shifts in FM-AFM measurements and demonstrate that the commonly used approach of minimizing the excitation amplitude can lead to significant phase detuning, particularly in liquid environments.

Communication and team situation awareness in the OR: Implications for augmentative information display.

PubMed

Parush, Avi; Kramer, Chelsea; Foster-Hunt, Tara; Momtahan, Kathryn; Hunter, Aren; Sohmer, Benjamin

2011-06-01

Team Situation Awareness (TSA) is one of the critical factors in effective Operating Room (OR) teamwork and can impact patient safety and quality of care. While previous research showed a relationship between situation awareness, as measured by communication events, and team performance, the implications for developing technology to augment and facilitate TSA were not examined. This research aims to further study situation-related communications in the cardiac OR in order to uncover potential degradation in TSA which may lead to adverse events. The communication loop construct-the full cycle of information flow between the participants in the sequence-was used to assess susceptibility to breakdown. Previous research and the findings here suggest that communication loops that are open, non-directed, or with delayed closure, can be susceptible to information loss. These were quantitatively related to communication indicators of TSA such as questions, replies, and announcements. Taken together, both qualitative and quantitative analyses suggest that a high proportion of TSA-related communication (63%) can be characterized as susceptible to information loss. The findings were then used to derive requirements and design a TSA augmentative display. The design principles and potential benefits of such a display are outlined and discussed. Copyright © 2010 Elsevier Inc. All rights reserved.

Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples

NASA Astrophysics Data System (ADS)

Wang, Chun Wei; Manne, Upender; Reddy, Vishnu B.; Oelschlager, Denise K.; Katkoori, Venkat R.; Grizzle, William E.; Kapoor, Rakesh

2010-11-01

A combination tapered fiber-optic biosensor (CTFOB) dip probe for rapid and cost-effective quantification of proteins in serum samples has been developed. This device relies on diode laser excitation and a charged-coupled device spectrometer and functions on a technique of sandwich immunoassay. As a proof of principle, this technique was applied in a quantitative estimation of interleukin IL-6. The probes detected IL-6 at picomolar levels in serum samples obtained from a patient with lupus, an autoimmune disease, and a patient with lymphoma. The estimated concentration of IL-6 in the lupus sample was 5.9 +/- 0.6 pM, and in the lymphoma sample, it was below the detection limit. These concentrations were verified by a procedure involving bead-based xMAP technology. A similar trend in the concentrations was observed. The specificity of the CTFOB dip probes was assessed by analysis with receiver operating characteristics. This analysis suggests that the dip probes can detect 5-pM or higher concentration of IL-6 in these samples with specificities of 100%. The results provide information for guiding further studies in the utilization of these probes to quantify other analytes in body fluids with high specificity and sensitivity.

Evaluating 'good governance': The development of a quantitative tool in the Greater Serengeti Ecosystem.

PubMed

Kisingo, Alex; Rollins, Rick; Murray, Grant; Dearden, Phil; Clarke, Marlea

2016-10-01

Protected areas (PAs) can provide important benefits to conservation and to communities. A key factor in the effective delivery of these benefits is the role of governance. There has been a growth in research developing frameworks to evaluate 'good' PA governance, usually drawing on a set of principles that are associated with groups of indicators. In contrast to dominant qualitative approaches, this paper describes the development of a quantitative method for measuring effectiveness of protected area governance, as perceived by stakeholders in the Greater Serengeti Ecosystem in Tanzania. The research developed a quantitative method for developing effectiveness measures of PA governance, using a set of 65 statements related to governance principles developed from a literature review. The instrument was administered to 389 individuals from communities located near PAs in the Greater Serengeti Ecosystem. The results of a factor analysis suggest that statements load onto 10 factors that demonstrate high psychometric validity as measured by factor loadings, explained variance, and Cronbach's alpha reliability. The ten common factors that were extracted were: 1) legitimacy, 2) transparency and accountability, 3) responsiveness, 4) fairness, 5) participation, 6) ecosystem based management (EBM) and connectivity, 7) resilience, 8) achievements, 9) consensus orientation, and 10) power. The paper concludes that quantitative surveys can be used to evaluate governance of protected areas from a community-level perspective. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Conceptual Framework for Defense Acquisition Decision Makers: Giving the Schedule its Due

DTIC Science & Technology

2014-01-01

Principles from microeconomic theory and operations research can provide insight into acquisition decisions to produce military capabili- ties in an...models based on economic and operations research principles can yield valuable insight into defense acquisition decisions. This article focuses on models...Department Edmund Conrow (1995) developed an excellent microeconomic framework to investigate the incentives of buyers and sellers in the defense

SLUMLORDS: Aerospace Power in Urban Fights

DTIC Science & Technology

2000-09-01

from the University of Texas, Austin, and a Masters in Organizational Management from George Washington University, Washington, DC. His teaching and...Findings 39 Figures 1. Battlespace Framework 16 2. Urban Terrain Zones 19 3. Urban System Graphic 20 4. Battlespace Framework 26 5. Principles of War... principles of war and military operations other than war (MOOTW). Section Five provides an introduction to operational effects that airmen can

Modular modelling with Physiome standards

PubMed Central

Nickerson, David P.; Nielsen, Poul M. F.; Hunter, Peter J.

2016-01-01

Key points The complexity of computational models is increasing, supported by research in modelling tools and frameworks. But relatively little thought has gone into design principles for complex models.We propose a set of design principles for complex model construction with the Physiome standard modelling protocol CellML.By following the principles, models are generated that are extensible and are themselves suitable for reuse in larger models of increasing complexity.We illustrate these principles with examples including an architectural prototype linking, for the first time, electrophysiology, thermodynamically compliant metabolism, signal transduction, gene regulation and synthetic biology.The design principles complement other Physiome research projects, facilitating the application of virtual experiment protocols and model analysis techniques to assist the modelling community in creating libraries of composable, characterised and simulatable quantitative descriptions of physiology. Abstract The ability to produce and customise complex computational models has great potential to have a positive impact on human health. As the field develops towards whole‐cell models and linking such models in multi‐scale frameworks to encompass tissue, organ, or organism levels, reuse of previous modelling efforts will become increasingly necessary. Any modelling group wishing to reuse existing computational models as modules for their own work faces many challenges in the context of construction, storage, retrieval, documentation and analysis of such modules. Physiome standards, frameworks and tools seek to address several of these challenges, especially for models expressed in the modular protocol CellML. Aside from providing a general ability to produce modules, there has been relatively little research work on architectural principles of CellML models that will enable reuse at larger scales. To complement and support the existing tools and frameworks, we develop a set of principles to address this consideration. The principles are illustrated with examples that couple electrophysiology, signalling, metabolism, gene regulation and synthetic biology, together forming an architectural prototype for whole‐cell modelling (including human intervention) in CellML. Such models illustrate how testable units of quantitative biophysical simulation can be constructed. Finally, future relationships between modular models so constructed and Physiome frameworks and tools are discussed, with particular reference to how such frameworks and tools can in turn be extended to complement and gain more benefit from the results of applying the principles. PMID:27353233

Distinguishing between forensic science and forensic pseudoscience: testing of validity and reliability, and approaches to forensic voice comparison.

PubMed

Morrison, Geoffrey Stewart

2014-05-01

In this paper it is argued that one should not attempt to directly assess whether a forensic analysis technique is scientifically acceptable. Rather one should first specify what one considers to be appropriate principles governing acceptable practice, then consider any particular approach in light of those principles. This paper focuses on one principle: the validity and reliability of an approach should be empirically tested under conditions reflecting those of the case under investigation using test data drawn from the relevant population. Versions of this principle have been key elements in several reports on forensic science, including forensic voice comparison, published over the last four-and-a-half decades. The aural-spectrographic approach to forensic voice comparison (also known as "voiceprint" or "voicegram" examination) and the currently widely practiced auditory-acoustic-phonetic approach are considered in light of this principle (these two approaches do not appear to be mutually exclusive). Approaches based on data, quantitative measurements, and statistical models are also considered in light of this principle. © 2013.

A Simple Model of Entrepreneurship for Principles of Economics Courses

ERIC Educational Resources Information Center

Gunter, Frank R.

2012-01-01

The critical roles of entrepreneurs in creating, operating, and destroying markets, as well as their importance in driving long-term economic growth are still generally either absent from principles of economics texts or relegated to later chapters. The primary difficulties in explaining entrepreneurship at the principles level are the lack of a…

77 FR 68130 - Agency Information Collection Activities; Proposed Collection; Comment Request; Voluntary Hazard...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Critical Control Point (HACCP) principles to reduce the risk of foodborne illness in the operation of... Control Number 0910-0578)--Extension HACCP principles are designed to reduce the occurrence of foodborne... manuals that interpret and promote the application of HACCP principles to reduce the risk of foodborne...

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XVII, LEARNING ABOUT AC GENERATOR (ALTERNATOR) PRINCIPLES (PART II).

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES AND THE SERVICING AND TESTING PROCEDURES FOR ALTERNATING CURRENT (AC) GENERATORS AND REGULATORS USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE REVIEW OF ALTERNATOR PRINCIPLES, ALTERNATOR SERVICING AND TESTING, ALTERNATOR REGULATOR OPERATING…

Modelling the thermomechanical behaviour of the tungsten first wall in HiPER laser fusion scenarios

NASA Astrophysics Data System (ADS)

Garoz, D.; Páramo, A. R.; Rivera, A.; Perlado, J. M.; González-Arrabal, R.

2016-12-01

The behaviour of a tungsten first wall is studied under the irradiation conditions predicted for the different operational scenarios of the European laser fusion project HiPER, which is based on direct drive targets and an evacuated dry wall chamber. The scenarios correspond to different stages in the development of a nuclear fusion reactor, from proof of principle (bunch mode facility) to economic feasibility (pre-commercial power plant). This work constitutes a quantitative study to evaluate first wall performance under realistic irradiation conditions in the different scenarios. We calculated the radiation fluxes assuming the geometrical configurations reported so far for HiPER. Then, we calculated the irradiation-induced evolution of first wall temperature and the thermomechanical response of the material. The results indicate that the first wall will plastically deform up to a few microns underneath the surface. Continuous operation in a power plant leads to fatigue failure with crack generation and growth. Finally, crack propagation and the minimum tungsten thickness required to fulfil the first wall protection role is studied. The response of tungsten as a first wall material as well as its main limitations will be discussed for the HiPER scenarios.

Risk based inspection for atmospheric storage tank

NASA Astrophysics Data System (ADS)

Nugroho, Agus; Haryadi, Gunawan Dwi; Ismail, Rifky; Kim, Seon Jin

2016-04-01

Corrosion is an attack that occurs on a metallic material as a result of environment's reaction.Thus, it causes atmospheric storage tank's leakage, material loss, environmental pollution, equipment failure and affects the age of process equipment then finally financial damage. Corrosion risk measurement becomesa vital part of Asset Management at the plant for operating any aging asset.This paper provides six case studies dealing with high speed diesel atmospheric storage tank parts at a power plant. A summary of the basic principles and procedures of corrosion risk analysis and RBI applicable to the Process Industries were discussed prior to the study. Semi quantitative method based onAPI 58I Base-Resource Document was employed. The risk associated with corrosion on the equipment in terms of its likelihood and its consequences were discussed. The corrosion risk analysis outcome used to formulate Risk Based Inspection (RBI) method that should be a part of the atmospheric storage tank operation at the plant. RBI gives more concern to inspection resources which are mostly on `High Risk' and `Medium Risk' criteria and less on `Low Risk' shell. Risk categories of the evaluated equipment were illustrated through case study analysis outcome.

Determinations of Carbon Dioxide by Titration: New Experiments for General, Physical, and Quantitative Analysis Courses.

ERIC Educational Resources Information Center

Crossno, S. K.; And Others

1996-01-01

Presents experiments involving the analysis of commercial products such as carbonated beverages and antacids that illustrate the principles of acid-base reactions and present interesting problems in stoichiometry for students. (JRH)

Integrating High-Reliability Principles to Transform Access and Throughput by Creating a Centralized Operations Center.

PubMed

Davenport, Paul B; Carter, Kimberly F; Echternach, Jeffrey M; Tuck, Christopher R

2018-02-01

High-reliability organizations (HROs) demonstrate unique and consistent characteristics, including operational sensitivity and control, situational awareness, hyperacute use of technology and data, and actionable process transformation. System complexity and reliance on information-based processes challenge healthcare organizations to replicate HRO processes. This article describes a healthcare organization's 3-year journey to achieve key HRO features to deliver high-quality, patient-centric care via an operations center powered by the principles of high-reliability data and software to impact patient throughput and flow.

A combined qualitative and quantitative procedure for the chemical analysis of urinary calculi

PubMed Central

Hodgkinson, A.

1971-01-01

A better understanding of the physico-chemical principles underlying the formation of calculus has led to a need for more precise information on the chemical composition of stones. A combined qualitative and quantitative procedure for the chemical analysis of urinary calculi which is suitable for routine use is presented. The procedure involves five simple qualitative tests followed by the quantitative determination of calcium, magnesium, inorganic phosphate, and oxalate. These data are used to calculate the composition of the stone in terms of calcium oxalate, apatite, and magnesium ammonium phosphate. Analytical results and derived values for five representative types of calculi are presented. PMID:5551382

Interdependence of PRECIS Role Operators: A Quantitative Analysis of Their Associations.

ERIC Educational Resources Information Center

Mahapatra, Manoranjan; Biswas, Subal Chandra

1986-01-01

Analyzes associations among different role operators quantitatively by taking input strings from 200 abstracts, each related to subject fields of taxation, genetic psychology, and Shakespearean drama, and subjecting them to the Chi-square test. Significant associations by other differencing operators and connectives are discussed. A schema of role…

Principles and application of shock-tubes and shock tunnels

NASA Technical Reports Server (NTRS)

Ried, R. C.; Clauss, H. G., Jr.

1963-01-01

The principles, theoretical flow equations, calculation techniques, limitations and practical performance characteristics of basic and high performance shock tubes and shock tunnels are presented. Selected operating curves are included.

Getting yourself healthy before surgery

MedlinePlus

... care - getting healthy References Neumayer L, Ghalyaie N. Principles of preoperative and operative surgery. In: Townsend CM, ... member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www. ...

Modular acute system for general surgery: hand over the operation, not the patient.

PubMed

Poole, Garth H; Glyn, Tamara; Srinivasa, Sanket; Hill, Andrew G

2012-03-01

Various models have been proposed to effectively provide acute surgical care in Australasia. Recently, General Surgeons Australia (GSA) has published a 12-point plan with guiding principles on this matter. This study describes a model of providing acute general surgical care in a high-volume institution, evaluates clinical outcomes and critically appraises the system against the GSA 12-point plan. The acute care system is qualitatively described with quantitative measures of workload. The outcomes of acute laparoscopic cholecystectomy were used as a proxy of system performance. The system was critically appraised against the GSA 12-point plan. Teams are on call once per week with each surgeon on call once per fortnight. The three key elements of acute management - collecting patients, post-acute ward round and operating - are treated as modules. The patient remains under the care of the admitting consultant but is often operated on by another team. From June 2009 to 2010, there were 7429 acute general surgical admissions (mean: 20.4 patients per day) with 2999 acute operations (mean: 8.4 operations per day). The other activities of the department were not compromised. In that time, 388 acute laparoscopic cholecystectomies were performed with a conversion rate of 1.3% and no major bile duct injury. The system is compatible with the GSA 12-point plan. This study describes an efficient and safe system for providing acute general surgical care in a high-volume setting with satisfactory clinical outcomes. It is compatible with the GSA 12-point plan. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

Voronovskaja's theorem revisited

NASA Astrophysics Data System (ADS)

Tachev, Gancho T.

2008-07-01

We represent a new quantitative variant of Voronovskaja's theorem for Bernstein operator. This estimate improves the recent quantitative versions of Voronovskaja's theorem for certain Bernstein-type operators, obtained by H. Gonska, P. Pitul and I. Rasa in 2006.

Naval Classical Thinkers and Operational Art

DTIC Science & Technology

2009-01-01

Principles and Practice of Military Operations on Land, published in 1911, did not attract as much attention as his previous two major works...thinker. He failed, for example, to consider factors such as social and cultural conditions in the rise of sea power; the rise of the English middle...three key ideas: the inherent value of a strategic central or interior position, the principle of concentration, and the close relationship between

Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein.

PubMed

Looby, Mairead; Ibarra, Neysi; Pierce, James J; Buckley, Kevin; O'Donovan, Eimear; Heenan, Mary; Moran, Enda; Farid, Suzanne S; Baganz, Frank

2011-01-01

This study describes the application of quality by design (QbD) principles to the development and implementation of a major manufacturing process improvement for a commercially distributed therapeutic protein produced in Chinese hamster ovary cell culture. The intent of this article is to focus on QbD concepts, and provide guidance and understanding on how the various components combine together to deliver a robust process in keeping with the principles of QbD. A fed-batch production culture and a virus inactivation step are described as representative examples of upstream and downstream unit operations that were characterized. A systematic approach incorporating QbD principles was applied to both unit operations, involving risk assessment of potential process failure points, small-scale model qualification, design and execution of experiments, definition of operating parameter ranges and process validation acceptance criteria followed by manufacturing-scale implementation and process validation. Statistical experimental designs were applied to the execution of process characterization studies evaluating the impact of operating parameters on product quality attributes and process performance parameters. Data from process characterization experiments were used to define the proven acceptable range and classification of operating parameters for each unit operation. Analysis of variance and Monte Carlo simulation methods were used to assess the appropriateness of process design spaces. Successful implementation and validation of the process in the manufacturing facility and the subsequent manufacture of hundreds of batches of this therapeutic protein verifies the approaches taken as a suitable model for the development, scale-up and operation of any biopharmaceutical manufacturing process. Copyright © 2011 American Institute of Chemical Engineers (AIChE).

Analysis of Ergot Alkaloids

PubMed Central

Crews, Colin

2015-01-01

The principles and application of established and newer methods for the quantitative and semi-quantitative determination of ergot alkaloids in food, feed, plant materials and animal tissues are reviewed. The techniques of sampling, extraction, clean-up, detection, quantification and validation are described. The major procedures for ergot alkaloid analysis comprise liquid chromatography with tandem mass spectrometry (LC-MS/MS) and liquid chromatography with fluorescence detection (LC-FLD). Other methods based on immunoassays are under development and variations of these and minor techniques are available for specific purposes. PMID:26046699

Three-dimensional quantitative flow diagnostics

NASA Technical Reports Server (NTRS)

Miles, Richard B.; Nosenchuck, Daniel M.

1989-01-01

The principles, capabilities, and practical implementation of advanced measurement techniques for the quantitative characterization of three-dimensional flows are reviewed. Consideration is given to particle, Rayleigh, and Raman scattering; fluorescence; flow marking by H2 bubbles, photochromism, photodissociation, and vibrationally excited molecules; light-sheet volume imaging; and stereo imaging. Also discussed are stereo schlieren methods, holographic particle imaging, optical tomography, acoustic and magnetic-resonance imaging, and the display of space-filling data. Extensive diagrams, graphs, photographs, sample images, and tables of numerical data are provided.

Technology study of quantum remote sensing imaging

NASA Astrophysics Data System (ADS)

Bi, Siwen; Lin, Xuling; Yang, Song; Wu, Zhiqiang

2016-02-01

According to remote sensing science and technology development and application requirements, quantum remote sensing is proposed. First on the background of quantum remote sensing, quantum remote sensing theory, information mechanism, imaging experiments and prototype principle prototype research situation, related research at home and abroad are briefly introduced. Then we expounds compress operator of the quantum remote sensing radiation field and the basic principles of single-mode compression operator, quantum quantum light field of remote sensing image compression experiment preparation and optical imaging, the quantum remote sensing imaging principle prototype, Quantum remote sensing spaceborne active imaging technology is brought forward, mainly including quantum remote sensing spaceborne active imaging system composition and working principle, preparation and injection compression light active imaging device and quantum noise amplification device. Finally, the summary of quantum remote sensing research in the past 15 years work and future development are introduced.

Chemical graphs, molecular matrices and topological indices in chemoinformatics and quantitative structure-activity relationships.

PubMed

Ivanciuc, Ovidiu

2013-06-01

Chemical and molecular graphs have fundamental applications in chemoinformatics, quantitative structureproperty relationships (QSPR), quantitative structure-activity relationships (QSAR), virtual screening of chemical libraries, and computational drug design. Chemoinformatics applications of graphs include chemical structure representation and coding, database search and retrieval, and physicochemical property prediction. QSPR, QSAR and virtual screening are based on the structure-property principle, which states that the physicochemical and biological properties of chemical compounds can be predicted from their chemical structure. Such structure-property correlations are usually developed from topological indices and fingerprints computed from the molecular graph and from molecular descriptors computed from the three-dimensional chemical structure. We present here a selection of the most important graph descriptors and topological indices, including molecular matrices, graph spectra, spectral moments, graph polynomials, and vertex topological indices. These graph descriptors are used to define several topological indices based on molecular connectivity, graph distance, reciprocal distance, distance-degree, distance-valency, spectra, polynomials, and information theory concepts. The molecular descriptors and topological indices can be developed with a more general approach, based on molecular graph operators, which define a family of graph indices related by a common formula. Graph descriptors and topological indices for molecules containing heteroatoms and multiple bonds are computed with weighting schemes based on atomic properties, such as the atomic number, covalent radius, or electronegativity. The correlation in QSPR and QSAR models can be improved by optimizing some parameters in the formula of topological indices, as demonstrated for structural descriptors based on atomic connectivity and graph distance.

Semi-quantitative visual detection of loop mediated isothermal amplification (LAMP)-generated DNA by distance-based measurement on a paper device.

PubMed

Hongwarittorrn, Irin; Chaichanawongsaroj, Nuntaree; Laiwattanapaisal, Wanida

2017-12-01

A distance-based paper analytical device (dPAD) for loop mediated isothermal amplification (LAMP) detection based on distance measurement was proposed. This approach relied on visual detection by the length of colour developed on the dPAD with reference to semi-quantitative determination of the initial amount of genomic DNA. In this communication, E. coli DNA was chosen as a template DNA for LAMP reaction. In accordance with the principle, the dPAD was immobilized by polyethylenimine (PEI), which is a strong cationic polymer, in the hydrophilic channel of the paper device. Hydroxynaphthol blue (HNB), a colourimetric indicator for monitoring the change of magnesium ion concentration in the LAMP reaction, was used to react with the immobilized PEI. The positive charges of PEI react with the negative charges of free HNB in the LAMP reaction, producing a blue colour deposit on the paper device. Consequently, the apparently visual distance appeared within 5min and length of distance correlated to the amount of DNA in the sample. The distance-based PAD for the visual detection of the LAMP reaction could quantify the initial concentration of genomic DNA as low as 4.14 × 10 3 copiesµL -1 . This distance-based visual semi-quantitative platform is suitable for choice of LAMP detection method, particular in resource-limited settings because of the advantages of low cost, simple fabrication and operation, disposability and portable detection of the dPAD device. Copyright © 2017 Elsevier B.V. All rights reserved.

Development and optimization of SPE-HPLC-UV/ELSD for simultaneous determination of nine bioactive components in Shenqi Fuzheng Injection based on Quality by Design principles.

PubMed

Wang, Lu; Qu, Haibin

2016-03-01

A method combining solid phase extraction, high performance liquid chromatography, and ultraviolet/evaporative light scattering detection (SPE-HPLC-UV/ELSD) was developed according to Quality by Design (QbD) principles and used to assay nine bioactive compounds within a botanical drug, Shenqi Fuzheng Injection. Risk assessment and a Plackett-Burman design were utilized to evaluate the impact of 11 factors on the resolutions and signal-to-noise of chromatographic peaks. Multiple regression and Pareto ranking analysis indicated that the sorbent mass, sample volume, flow rate, column temperature, evaporator temperature, and gas flow rate were statistically significant (p < 0.05) in this procedure. Furthermore, a Box-Behnken design combined with response surface analysis was employed to study the relationships between the quality of SPE-HPLC-UV/ELSD analysis and four significant factors, i.e., flow rate, column temperature, evaporator temperature, and gas flow rate. An analytical design space of SPE-HPLC-UV/ELSD was then constructed by calculated Monte Carlo probability. In the presented approach, the operating parameters of sample preparation, chromatographic separation, and compound detection were investigated simultaneously. Eight terms of method validation, i.e., system-suitability tests, method robustness/ruggedness, sensitivity, precision, repeatability, linearity, accuracy, and stability, were accomplished at a selected working point. These results revealed that the QbD principles were suitable in the development of analytical procedures for samples in complex matrices. Meanwhile, the analytical quality and method robustness were validated by the analytical design space. The presented strategy provides a tutorial on the development of a robust QbD-compliant quantitative method for samples in complex matrices.

Katherine Young, P.E. | NREL

Science.gov Websites

) Water rights and resources engineering Database planning and development Research Interests Collection lean principles to streamline exploration and drilling and reduce error/risk Research, development and Groundwater modeling Quantitative methods in water resource engineering Water resource engineering and

Combat Leader Characteristics

DTIC Science & Technology

1990-05-01

from the business schools , namely, principles of bargaining, emotional control, human relations skills, and the technology of quantitative control. They...the managerial mystique being taught in our business schools and practiced in our businesses. (61:6--.7) His logic is still that Jeaders and managers

Calculation of Drug Solubilities by Pharmacy Students.

ERIC Educational Resources Information Center

Cates, Lindley A.

1981-01-01

A method of estimating the solubilities of drugs in water is reported that is based on a principle applied in quantitative structure-activity relationships. This procedure involves correlation of partition coefficient values using the octanol/water system and aqueous solubility. (Author/MLW)

Principles of Economic Rationality in Mice.

PubMed

Rivalan, Marion; Winter, York; Nachev, Vladislav

2017-12-12

Humans and non-human animals frequently violate principles of economic rationality, such as transitivity, independence of irrelevant alternatives, and regularity. The conditions that lead to these violations are not completely understood. Here we report a study on mice tested in automated home-cage setups using rewards of drinking water. Rewards differed in one of two dimensions, volume or probability. Our results suggest that mouse choice conforms to the principles of economic rationality for options that differ along a single reward dimension. A psychometric analysis of mouse choices further revealed that mice responded more strongly to differences in probability than to differences in volume, despite equivalence in return rates. This study also demonstrates the synergistic effect between the principles of economic rationality and psychophysics in making quantitative predictions about choices of healthy laboratory mice. This opens up new possibilities for the analyses of multi-dimensional choice and the use of mice with cognitive impairments that may violate economic rationality.

45 CFR 170.423 - Principles of proper conduct for ONC-ATCBs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Principles of proper conduct for ONC-ATCBs. 170... § 170.423 Principles of proper conduct for ONC-ATCBs. An ONC-ATCB shall: (a) Operate its certification... EHR Module developer conspicuously include the following text on its Web site and in all marketing...

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XIV, UNDERSTANDING DC GENERATOR PRINCIPLES.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES OF DIRECT CURRENT GENERATORS USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE (1) WHAT IS A GENERATOR AND ITS USE, (2) SHUNT GENERATOR PRINCIPLES, (3) POWER AND RATINGS OF A GENERATOR, (4) ARMATURE REACTION, (5) WHAT IS POLARITY, (6) TWO GENERATOR…

Optofluidic time-stretch quantitative phase microscopy.

PubMed

Guo, Baoshan; Lei, Cheng; Wu, Yi; Kobayashi, Hirofumi; Ito, Takuro; Yalikun, Yaxiaer; Lee, Sangwook; Isozaki, Akihiro; Li, Ming; Jiang, Yiyue; Yasumoto, Atsushi; Di Carlo, Dino; Tanaka, Yo; Yatomi, Yutaka; Ozeki, Yasuyuki; Goda, Keisuke

2018-03-01

Innovations in optical microscopy have opened new windows onto scientific research, industrial quality control, and medical practice over the last few decades. One of such innovations is optofluidic time-stretch quantitative phase microscopy - an emerging method for high-throughput quantitative phase imaging that builds on the interference between temporally stretched signal and reference pulses by using dispersive properties of light in both spatial and temporal domains in an interferometric configuration on a microfluidic platform. It achieves the continuous acquisition of both intensity and phase images with a high throughput of more than 10,000 particles or cells per second by overcoming speed limitations that exist in conventional quantitative phase imaging methods. Applications enabled by such capabilities are versatile and include characterization of cancer cells and microalgal cultures. In this paper, we review the principles and applications of optofluidic time-stretch quantitative phase microscopy and discuss its future perspective. Copyright © 2017 Elsevier Inc. All rights reserved.

Positron Emission Tomography: Principles, Technology, and Recent Developments

NASA Astrophysics Data System (ADS)

Ziegler, Sibylle I.

2005-04-01

Positron emission tomography (PET) is a nuclear medical imaging technique for quantitative measurement of physiologic parameters in vivo (an overview of principles and applications can be found in [P.E. Valk, et al., eds. Positron Emission Tomography. Basic Science and Clinical Practice. 2003, Springer: Heidelberg]), based on the detection of small amounts of posi-tron-emitter-labelled biologic molecules. Various radiotracers are available for neuro-logical, cardiological, and oncological applications in the clinic and in research proto-cols. This overview describes the basic principles, technology, and recent develop-ments in PET, followed by a section on the development of a tomograph with ava-lanche photodiodes dedicated for small animal imaging as an example of efforts in the domain of high resolution tomographs.

Principles of adoption of the successful environmental practices used in developed countries into mining industry in developing countries.

NASA Astrophysics Data System (ADS)

Masaitis, Alexandra

2013-04-01

The successful implementation of the environmental practices in the mining industry is of a paramount importance, as it not only prevents both local and trans-border pollution but also guarantees clean and healthy environment for the people regardless of their place of habitation. It is especially important to encourage the progress of the environmental practices implementation in developing countries because such countries have resource-oriented economy based on exploitation of nonrenewable resources. Poor environmental practices in developing countries will lead to local environmental crises that could eventually spill into surrounding countries including the most economically advanced. This abstract is a summary of a two-year research project attempted (1) to determine deficiencies of the mining sector ecological practices in developing countries and (2) to suggest substitute practices from developed countries that could be adapted to the developing countries reality. The following research methods were used: 1. The method of the system analysis, where the system is an interaction of the sets of environmental practices with the global mining sector; 2. The comparative method of inquiry, where the comparison was made between environmental protection practices as implemented in the US (developed country) and the developing countries such as RF, Mongolia mining sectors; 3. Quantitative date analysis, where date was collected from "The collection of statistic data", Russian Geographic Society Annual reports, the US EPA open reports, and the USGS Reports; The following results were obtained: Identified the systemic crisis of the ecological environmental policies and practices in the mining sector in developing countries based on the exploitation of nonrenewable resources, absence of the ecological interest by the mining companies that lack mechanisms of environmental and public health protection, the lack of insurance policy, the lack of risk assistance, and in the presence of the audit and monitoring that do not address the local conditions of the mining operations. Based on the above the following concepts were thought of to improve the environmental conditions in mining sector: 1. Was developed the Regional Environmental Management principle based on the local conditions such as physiographic region, local population, and socioeconomic conditions of the area; 2. Devised were criteria for the risk assessment for developing countries. Where the fundamental principals were public health, both near and far from the operation, environmental and biodiversity impact, waste management, long- and short- term rehabilitation plans, compliance with international standards and norms. 3. Developed was the mechanism of the economic motivation to make mining operations "environmentally friendly" that includes defrayal of expenses from both direct and indirect damages. 4. Identified were spheres of possible cooperation between mining companies, government organizations, and the NGOs. These include development of international standards for Good Neighbor Agreement, exchange of environmental information, exchange of successful environmental, health, and safety practices between mining operations from developed and developing countries. The study showed the dire necessity for the mining industry that operates in developing countries to adopt the successful environmental practices used in developed countries. To achieve this goal the Regional Environmental Management principle, the risk assessment criteria, the mechanism of the economic motivation and the principles for international cooperation can play an extremely important role.

Voltage Imaging of Waking Mouse Cortex Reveals Emergence of Critical Neuronal Dynamics

PubMed Central

Scott, Gregory; Fagerholm, Erik D.; Mutoh, Hiroki; Leech, Robert; Sharp, David J.; Shew, Woodrow L.

2014-01-01

Complex cognitive processes require neuronal activity to be coordinated across multiple scales, ranging from local microcircuits to cortex-wide networks. However, multiscale cortical dynamics are not well understood because few experimental approaches have provided sufficient support for hypotheses involving multiscale interactions. To address these limitations, we used, in experiments involving mice, genetically encoded voltage indicator imaging, which measures cortex-wide electrical activity at high spatiotemporal resolution. Here we show that, as mice recovered from anesthesia, scale-invariant spatiotemporal patterns of neuronal activity gradually emerge. We show for the first time that this scale-invariant activity spans four orders of magnitude in awake mice. In contrast, we found that the cortical dynamics of anesthetized mice were not scale invariant. Our results bridge empirical evidence from disparate scales and support theoretical predictions that the awake cortex operates in a dynamical regime known as criticality. The criticality hypothesis predicts that small-scale cortical dynamics are governed by the same principles as those governing larger-scale dynamics. Importantly, these scale-invariant principles also optimize certain aspects of information processing. Our results suggest that during the emergence from anesthesia, criticality arises as information processing demands increase. We expect that, as measurement tools advance toward larger scales and greater resolution, the multiscale framework offered by criticality will continue to provide quantitative predictions and insight on how neurons, microcircuits, and large-scale networks are dynamically coordinated in the brain. PMID:25505314

Information properties of morphologically complex words modulate brain activity during word reading

PubMed Central

Hultén, Annika; Lehtonen, Minna; Lagus, Krista; Salmelin, Riitta

2018-01-01

Abstract Neuroimaging studies of the reading process point to functionally distinct stages in word recognition. Yet, current understanding of the operations linked to those various stages is mainly descriptive in nature. Approaches developed in the field of computational linguistics may offer a more quantitative approach for understanding brain dynamics. Our aim was to evaluate whether a statistical model of morphology, with well‐defined computational principles, can capture the neural dynamics of reading, using the concept of surprisal from information theory as the common measure. The Morfessor model, created for unsupervised discovery of morphemes, is based on the minimum description length principle and attempts to find optimal units of representation for complex words. In a word recognition task, we correlated brain responses to word surprisal values derived from Morfessor and from other psycholinguistic variables that have been linked with various levels of linguistic abstraction. The magnetoencephalography data analysis focused on spatially, temporally and functionally distinct components of cortical activation observed in reading tasks. The early occipital and occipito‐temporal responses were correlated with parameters relating to visual complexity and orthographic properties, whereas the later bilateral superior temporal activation was correlated with whole‐word based and morphological models. The results show that the word processing costs estimated by the statistical Morfessor model are relevant for brain dynamics of reading during late processing stages. PMID:29524274

Micro-electromembrane extraction across free liquid membranes. Instrumentation and basic principles.

PubMed

Kubáň, Pavel; Boček, Petr

2014-06-13

A micro-electromembrane extraction (μ-EME) technique using electrically induced transfer of charged analytes across free liquid membranes (FLMs) was presented. A disposable extraction unit was proposed and it was made of a short segment of transparent perfluoroalkoxy tubing, which was successively filled with three liquid plugs serving as acceptor solution, FLM and donor solution. These plugs formed a three-phase extraction system, which was precisely defined, that was stable and required μL to sub-μL volumes of all respective solutions. Basic instrumental set-up and extraction principles of μ-EME were examined using an anionic and a cationic dye, 4,5-dihydroxy-3-(p-sulfophenylazo)-2,7-naphthalene disulfonic acid trisodium salt (SPADNS) and crystal violet, respectively. Transfers of the charged dyes from donor into acceptor solutions across FLMs consisting of 1-pentanol were visualized by a microscope camera and quantitative measurements were performed by UV-vis spectrophotometry. The effects of operational parameters of μ-EME system were comprehensively investigated and experimental measurements were accompanied with theoretical calculations. Extraction recoveries above 60% were achieved for 5min μ-EME of 1mM SPADNS at 100V with repeatability values below 5%. Selectivity of FLMs was additionally examined by capillary electrophoretic analyses of acceptor solutions and the potential of FLMs for μ-EME pretreatment of samples with artificial complex matrices was demonstrated. Copyright © 2014 Elsevier B.V. All rights reserved.

Space Weather, Geomagnetic Disturbances and Impact on the High-Voltage Transmission Systems

NASA Technical Reports Server (NTRS)

Pullkkinen, A.

2011-01-01

Geomagnetically induced currents (GIC) affecting the performance of high-voltage power transmission systems are one of the most significant hazards space weather poses on the operability of critical US infrastructure. The severity of the threat was emphasized, for example, in two recent reports: the National Research Council (NRC) report "Severe Space Weather Events--Understanding Societal and Economic Impacts: A Workshop Report" and the North American Electric Reliability Corporation (NERC) report "HighImpact, Low-Frequency Event Risk to the North American Bulk Power System." The NRC and NERC reports demonstrated the important national security dimension of space weather and GIC and called for comprehensive actions to forecast and mitigate the hazard. In this paper we will give a brief overview of space weather storms and accompanying geomagnetic storm events that lead to GIC. We will also review the fundamental principles of how GIC can impact the power transmission systems. Space weather has been a subject of great scientific advances that have changed the wonder of the past to a quantitative field of physics with true predictive power of today. NASA's Solar Shield system aimed at forecasting of GIC in the North American high-voltage power transmission system can be considered as one of the ultimate fruits of those advances. We will review the fundamental principles of the Solar Shield system and provide our view of the way forward in the science of GIC.

[Application of Raman Spectroscopy Technique to Agricultural Products Quality and Safety Determination].

PubMed

Liu, Yan-de; Jin, Tan-tan

2015-09-01

The quality and safety of agricultural products and people health are inseparable. Using the conventional chemical methods which have so many defects, such as sample pretreatment, complicated operation process and destroying the samples. Raman spectroscopy as a powerful tool of analysing and testing molecular structure, can implement samples quickly without damage, qualitative and quantitative detection analysis. With the continuous improvement and the scope of the application of Raman spectroscopy technology gradually widen, Raman spectroscopy technique plays an important role in agricultural products quality and safety determination, and has wide application prospects. There have been a lot of related research reports based on Raman spectroscopy detection on agricultural product quality safety at present. For the understanding of the principle of detection and the current development situation of Raman spectroscopy, as well as tracking the latest research progress both at home and abroad, the basic principles and the development of Raman spectroscopy as well as the detection device were introduced briefly. The latest research progress of quality and safety determination in fruits and vegetables, livestock and grain by Raman spectroscopy technique were reviewed deeply. Its technical problems for agricultural products quality and safety determination were pointed out. In addition, the text also briefly introduces some information of Raman spectrometer and the application for patent of the portable Raman spectrometer, prospects the future research and application.

Development of Team Action Projects in Surgery (TAPS): a multilevel team-based approach to teaching quality improvement.

PubMed

Waits, Seth A; Reames, Bradley N; Krell, Robert W; Bryner, Benjamin; Shih, Terry; Obi, Andrea T; Henke, Peter K; Minter, Rebecca M; Englesbe, Michael J; Wong, Sandra L

2014-01-01

To meet the Accreditation Council for Graduate Medical Education core competency in Practice-Based Learning and Improvement, educational curricula need to address training in quality improvement (QI). We sought to establish a program to train residents in the principles of QI and to provide practical experiences in developing and implementing improvement projects. We present a novel approach for engaging students, residents, and faculty in QI efforts-Team Action Projects in Surgery (TAPS). Large academic medical center and health system. Multiple teams consisting of undergraduate students, medical students, surgery residents, and surgery faculty were assembled and QI projects developed. Using "managing to learn" Lean principles, these multilevel groups approached each project with robust data collection, development of an A3, and implementation of QI activities. A total of 5 resident led QI projects were developed during the TAPS pilot phase. These included a living kidney donor enhanced recovery protocol, consult improvement process, venous thromboembolism prophylaxis optimization, Clostridium difficile treatment standardization, and understanding variation in operative duration of laparoscopic cholecystectomy. Qualitative and quantitative assessment showed significant value for both the learner and stakeholders of QI related projects. Through the development of TAPS, we demonstrate a novel approach to addressing the increasing focus on QI within graduate medical education. Efforts to expand this multilevel team based approach would have value for teachers and learners alike. Copyright © 2014. Published by Elsevier Inc.

Information properties of morphologically complex words modulate brain activity during word reading.

PubMed

Hakala, Tero; Hultén, Annika; Lehtonen, Minna; Lagus, Krista; Salmelin, Riitta

2018-06-01

Neuroimaging studies of the reading process point to functionally distinct stages in word recognition. Yet, current understanding of the operations linked to those various stages is mainly descriptive in nature. Approaches developed in the field of computational linguistics may offer a more quantitative approach for understanding brain dynamics. Our aim was to evaluate whether a statistical model of morphology, with well-defined computational principles, can capture the neural dynamics of reading, using the concept of surprisal from information theory as the common measure. The Morfessor model, created for unsupervised discovery of morphemes, is based on the minimum description length principle and attempts to find optimal units of representation for complex words. In a word recognition task, we correlated brain responses to word surprisal values derived from Morfessor and from other psycholinguistic variables that have been linked with various levels of linguistic abstraction. The magnetoencephalography data analysis focused on spatially, temporally and functionally distinct components of cortical activation observed in reading tasks. The early occipital and occipito-temporal responses were correlated with parameters relating to visual complexity and orthographic properties, whereas the later bilateral superior temporal activation was correlated with whole-word based and morphological models. The results show that the word processing costs estimated by the statistical Morfessor model are relevant for brain dynamics of reading during late processing stages. © 2018 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

The principle and application of new PCR Technologies

NASA Astrophysics Data System (ADS)

Yu, Miao; Cao, Yue; Ji, Yubin

2017-12-01

Polymerase chain reaction (PCR) is essentially a selective DNA amplification technique commonlyapplied for genetic testing and molecular diagnosis because of its high specificity and sensitivity.PCR technologies as the key of molecular biology, has realized that the qualitative detection of absolute quantitative has been changed. It has produced a variety of new PCR technologies, such as extreme PCR, photonic PCR, o-amplification at lower denaturation temperature PCR, nanoparticle PCR and so on. In this paper, the principle and application of PCR technologies are reviewed, and its development is prospected too.

Principles and Applications of Geochemistry, 2nd Edition

NASA Astrophysics Data System (ADS)

Marcantonio, Franco

Many academic geology departments do not include geochemistry in their undergraduate core curriculums. The second edition of Principles and Applications of Geochemistry demonstrates why this should change. Gunter Faure's book clearly shows the important role played by quantitative geochemical analysis in our understanding of Earth processes, both natural and anthropogenic. Intended as an introductory inorganic geochemistry text for senior undergraduates or first-year graduate students, the book makes even the most difficult concepts readily understandable. Beyond its lucid technical explanations, it also includes engaging discussions of the history of geochemistry as a science.

First-principles study of length dependence of conductance in alkanedithiols

NASA Astrophysics Data System (ADS)

Zhou, Y. X.; Jiang, F.; Chen, H.; Note, R.; Mizuseki, H.; Kawazoe, Y.

2008-01-01

Electronic transport properties of alkanedithiols are calculated by a first-principles method based on density functional theory and nonequilibrium Green's function formalism. At small bias, the I-V characteristics are linear and the resistances conform to the Magoga's exponential law. The calculated length-dependent decay constant γ which reflects the effect of internal molecular structure is in accordance with most experiments quantitatively. Also, the calculated effective contact resistance R0 is in good agreement with the results of repeatedly measuring molecule-electrode junctions [B. Xu and N. Tao, Science 301, 1221 (2003)].

The role of biomechanics in maximising distance and accuracy of golf shots.

PubMed

Hume, Patria A; Keogh, Justin; Reid, Duncan

2005-01-01

Golf biomechanics applies the principles and technique of mechanics to the structure and function of the golfer in an effort to improve golf technique and performance. A common recommendation for technical correction is maintaining a single fixed centre hub of rotation with a two-lever one-hinge moment arm to impart force on the ball. The primary and secondary spinal angles are important for conservation of angular momentum using the kinetic link principle to generate high club-head velocity. When the golfer wants to maximise the distance of their drives, relatively large ground reaction forces (GRF) need to be produced. However, during the backswing, a greater proportion of the GRF will be observed on the back foot, with transfer of the GRF on to the front foot during the downswing/acceleration phase. Rapidly stretching hip, trunk and upper limb muscles during the backswing, maximising the X-factor early in the downswing, and uncocking the wrists when the lead arm is about 30 degrees below the horizontal will take advantage of the summation of force principle. This will help generate large angular velocity of the club head, and ultimately ball displacement. Physical conditioning will help to recruit the muscles in the correct sequence and to optimum effect. To maximise the accuracy of chipping and putting shots, the golfer should produce a lower grip on the club and a slower/shorter backswing. Consistent patterns of shoulder and wrist movements and temporal patterning result in successful chip shots. Qualitative and quantitative methods are used to biomechanically assess golf techniques. Two- and three-dimensional videography, force plate analysis and electromyography techniques have been employed. The common golf biomechanics principles necessary to understand golf technique are stability, Newton's laws of motion (inertia, acceleration, action reaction), lever arms, conservation of angular momentum, projectiles, the kinetic link principle and the stretch-shorten cycle. Biomechanics has a role in maximising the distance and accuracy of all golf shots (swing and putting) by providing both qualitative and quantitative evidence of body angles, joint forces and muscle activity patterns. The quantitative biomechanical data needs to be interpreted by the biomechanist and translated into coaching points for golf professionals and coaches. An understanding of correct technique will help the sports medicine practitioner provide sound technical advice and should help reduce the risk of golfing injury.

47 CFR 32.1 - Background.

Code of Federal Regulations, 2010 CFR

2010-10-01

... financial accounting system which reports the results of operational and financial events in a manner which... permit upon the consistency of the well established body of accounting theories and principles commonly referred to as generally accepted accounting principles. ...

Dynamic sealing principles

NASA Technical Reports Server (NTRS)

Zuk, J.

1976-01-01

The fundamental principles governing dynamic sealing operation are discussed. Different seals are described in terms of these principles. Despite the large variety of detailed construction, there appear to be some basic principles, or combinations of basic principles, by which all seals function, these are presented and discussed. Theoretical and practical considerations in the application of these principles are discussed. Advantages, disadvantages, limitations, and application examples of various conventional and special seals are presented. Fundamental equations governing liquid and gas flows in thin film seals, which enable leakage calculations to be made, are also presented. Concept of flow functions, application of Reynolds lubrication equation, and nonlubrication equation flow, friction and wear; and seal lubrication regimes are explained.

Principles of Automation for Patient Safety in Intensive Care: Learning From Aviation.

PubMed

Dominiczak, Jason; Khansa, Lara

2018-06-01

The transition away from written documentation and analog methods has opened up the possibility of leveraging data science and analytic techniques to improve health care. In the implementation of data science techniques and methodologies, high-acuity patients in the ICU can particularly benefit. The Principles of Automation for Patient Safety in Intensive Care (PASPIC) framework draws on Billings's principles of human-centered aviation (HCA) automation and helps in identifying the advantages, pitfalls, and unintended consequences of automation in health care. Billings's HCA principles are based on the premise that human operators must remain "in command," so that they are continuously informed and actively involved in all aspects of system operations. In addition, automated systems need to be predictable, simple to train, to learn, and to operate, and must be able to monitor the human operators, and every intelligent system element must know the intent of other intelligent system elements. In applying Billings's HCA principles to the ICU setting, PAPSIC has three key characteristics: (1) integration and better interoperability, (2) multidimensional analysis, and (3) enhanced situation awareness. PAPSIC suggests that health care professionals reduce overreliance on automation and implement "cooperative automation" and that vendors reduce mode errors and embrace interoperability. Much can be learned from the aviation industry in automating the ICU. Because it combines "smart" technology with the necessary controls to withstand unintended consequences, PAPSIC could help ensure more informed decision making in the ICU and better patient care. Copyright © 2018 The Joint Commission. Published by Elsevier Inc. All rights reserved.

The Best Interest Standard: Same Name but Different Roles in Pediatric Bioethics and Child Rights Frameworks.

PubMed

Ross, Lainie Friedman; Swota, Alissa Hurwitz

2017-01-01

This article explores the intersection of pediatric bioethics and child rights by examining the best interest standard as it operates within the pediatric bioethics framework in the United States and the child rights framework based on the UN 1989 Convention on the Rights of the Child (CRC). While the "best interest of the child" standard is central to both pediatric bioethics and the child rights community, it operates only as a guidance principle, and not as an intervention principle, in decision-making within U.S. pediatric bioethics, whereas it operates as both a guidance and intervention principle in the child rights community. The differences in how the best interest standard is operationalized lead to different roles for the family, the state, and the minor in decision-making processes and outcomes. We examine the recent case of Charlie Gard to illustrate some of these differences.

MEMS actuators and sensors: observations on their performance and selection for purpose

NASA Astrophysics Data System (ADS)

Bell, D. J.; Lu, T. J.; Fleck, N. A.; Spearing, S. M.

2005-07-01

This paper presents an exercise in comparing the performance of microelectromechanical systems (MEMS) actuators and sensors as a function of operating principle. Data have been obtained from the literature for the mechanical performance characteristics of actuators, force sensors and displacement sensors. On-chip and off-chip actuators and sensors are each sub-grouped into families, classes and members according to their principle of operation. The performance of MEMS sharing common operating principles is compared with each other and with equivalent macroscopic devices. The data are used to construct performance maps showing the capability of existing actuators and sensors in terms of maximum force and displacement capability, resolution and frequency. These can also be used as a preliminary design tool, as shown in a case study on the design of an on-chip tensile test machine for materials in thin-film form.

Zebrafish housing systems: a review of basic operating principles and considerations for design and functionality.

PubMed

Lawrence, Christian; Mason, Timothy

2012-01-01

The strategies for housing zebrafish used in biomedical research have evolved considerably over the past three decades. To keep pace with the rapid expansion and development of the zebrafish model system, the field has generally moved from keeping fish at the level of aquarium hobbyist to that of industrialized, recirculating aquaculture. Numerous commercial system vendors now offer increasingly sophisticated housing systems based on design principles that maximize the number of animals that can be housed in a given space footprint, and they are thus able to support large and diverse research programs. This review is designed to provide managers, lab animal veterinarians, investigators, and other parties responsible for care and use of these animals with a comprehensive overview of the basic operating and design principles of zebrafish housing systems. This information can be used to help plan the construction of new facilities and/or the upgrade and maintenance of existing operations.

General quantitative analysis of stress partitioning and boundary conditions in undrained biphasic porous media via a purely macroscopic and purely variational approach

NASA Astrophysics Data System (ADS)

Serpieri, Roberto; Travascio, Francesco

2016-03-01

In poroelasticity, the effective stress law relates the external stress applied to the medium to the macroscopic strain of the solid phase and the interstitial pressure of the fluid saturating the mixture. Such relationship has been formerly introduced by Terzaghi in form of a principle. To date, no poroelastic theory is capable of recovering a stress partitioning law in agreement with Terzaghi's postulated one in the absence of ad hoc constitutive assumptions on the medium. We recently proposed a variational macroscopic continuum description of two-phase poroelasticity to derive a general biphasic formulation at finite deformations, termed variational macroscopic theory of porous media (VMTPM). Such approach proceeds from the inclusion of the intrinsic volumetric strain among the kinematic descriptors aside to macroscopic displacements, and as a variational theory, uses the Hamilton least-action principle as the unique primitive concept of mechanics invoked to derive momentum balance equations. In a previous related work it was shown that, for the subclass of undrained problems, VMTPM predicts that stress is partitioned in the two phases in strict compliance with Terzaghi's law, irrespective of the microstructural and constitutive features of a given medium. In the present contribution, we further develop the linearized framework of VMTPM to arrive at a general operative formula that allows the quantitative determination of stress partitioning in a jacketed test over a generic isotropic biphasic specimen. This formula is quantitative and general, in that it relates the partial phase stresses to the externally applied stress as function of partitioning coefficients that are all derived by strictly following a purely variational and purely macroscopic approach, and in the absence of any specific hypothesis on the microstructural or constitutive features of a given medium. To achieve this result, the stiffness coefficients of the theory are derived by using exclusively variational arguments. We derive the boundary conditions attained across the boundary of a poroelastic saturated medium in contact with an impermeable surface also based on purely variational arguments. A technique to retrieve bounds for the resulting elastic moduli, based on Hashin's composite spheres assemblage method, is also reported. Notably, in spite of the minimal mechanical hypotheses introduced, a rich mechanical behavior is observed.

Machine & electrical double control air dryer for vehicle air braking system

NASA Astrophysics Data System (ADS)

Zhang, Xuan; Yang, Liu; Wang, Xian Yan; Tan, Xiao Yan; Wang, Wei

2017-09-01

As is known to all, a vehicle air brake system, in which usually contains moisture. To solve the problem, it is common to use air dryer to dry compressed air effectively and completely remove the moisture and oil of braking system. However, the existing air dryer is not suitable for all commercial vehicles. According to the operational status of the new energy vehicles in the initial operating period, the structure design principle of the machine & electric control air dryer is expounded from the aspects of the structure and operating principle, research & development process.

40 CFR 60.5130 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, sewage...

40 CFR 60.5130 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

... types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, sewage...

Microeconomics, Private Security, and the Significance to Operational Planning

DTIC Science & Technology

2013-05-23

of microeconomic principles of supply-demand theory by looking at specific conceptual variables to determine the relationship and influence on the... microeconomic principles of supply-demand theory by looking at specific conceptual variables to determine the relationship and influence on the...study to include existing conceptual understandings of the industry, the microeconomic principles of supply- demand theory, the theoretic framework

The Duality Principle in Teaching Arithmetic and Geometric Series

ERIC Educational Resources Information Center

Yeshurun, Shraga

1978-01-01

The author discusses the use of the duality principle in combination with the hierarchy of algebraic operations in helping students to retain and use definitions and rules for arithmetic and geometric sequences and series. (MN)

Quantitating Human Optic Disc Topography

NASA Astrophysics Data System (ADS)

Graebel, William P.; Cohan, Bruce E.; Pearch, Andrew C.

1980-07-01

A method is presented for quantitatively expressing the topography of the human optic disc, applicable in a clinical setting to the diagnosis and management of glaucoma. Pho-tographs of the disc illuminated by a pattern of fine, high contrast parallel lines are digitized. From the measured deviation of the lines as they traverse the disc surface, disc topography is calculated, using the principles of optical sectioning. The quantitators applied to express this topography have the the following advantages : sensitivity to disc shape; objectivity; going beyond the limits of cup-disc ratio estimates and volume calculations; perfect generality in a mathematical sense; an inherent scheme for determining a non-subjective reference frame to compare different discs or the same disc over time.

Complementary techniques: validation of gene expression data by quantitative real time PCR.

PubMed

Provenzano, Maurizio; Mocellin, Simone

2007-01-01

Microarray technology can be considered the most powerful tool for screening gene expression profiles of biological samples. After data mining, results need to be validated with highly reliable biotechniques allowing for precise quantitation of transcriptional abundance of identified genes. Quantitative real time PCR (qrt-PCR) technology has recently reached a level of sensitivity, accuracy and practical ease that support its use as a routine bioinstrumentation for gene level measurement. Currently, qrt-PCR is considered by most experts the most appropriate method to confirm or confute microarray-generated data. The knowledge of the biochemical principles underlying qrt-PCR as well as some related technical issues must be beard in mind when using this biotechnology.

Aspects of operational radiation protection during dismantling of nuclear facilities relevant for the estimation of internal doses.

PubMed

Labarta, T

2007-01-01

Operational radiation protection of workers during the dismantling of nuclear facilities is based on the same radiation protection principles as that applied in its exploitation period with the objective of ensuring proper implementation of the as-low-as-reasonably-achievable (ALARA) principle. These principles are: prior determination of the nature and magnitude of radiological risk; classification of workplaces and workers depending on the risks; implementation of control measures; monitoring of zones and working conditions, including, if necessary, individual monitoring. From the experiences and the lessons learned during the dismantling processes carried out in Spain, several important aspects in the practical implementation of these principles that directly influence and ensure an adequate prevention of exposures and the estimation of internal doses are pointed out, with special emphasis on the estimation of internal doses due to transuranic intakes.

Minimum energy dissipation required for a logically irreversible operation

NASA Astrophysics Data System (ADS)

Takeuchi, Naoki; Yoshikawa, Nobuyuki

2018-01-01

According to Landauer's principle, the minimum heat emission required for computing is linked to logical entropy, or logical reversibility. The validity of Landauer's principle has been investigated for several decades and was finally demonstrated in recent experiments by showing that the minimum heat emission is associated with the reduction in logical entropy during a logically irreversible operation. Although the relationship between minimum heat emission and logical reversibility is being revealed, it is not clear how much free energy is required to be dissipated for a logically irreversible operation. In the present study, in order to reveal the connection between logical reversibility and free energy dissipation, we numerically demonstrated logically irreversible protocols using adiabatic superconductor logic. The calculation results of work during the protocol showed that, while the minimum heat emission conforms to Landauer's principle, the free energy dissipation can be arbitrarily reduced by performing the protocol quasistatically. The above results show that logical reversibility is not associated with thermodynamic reversibility, and that heat is not only emitted from logic devices but also absorbed by logic devices. We also formulated the heat emission from adiabatic superconductor logic during a logically irreversible operation at a finite operation speed.

Space Station overall management approach for operations

NASA Technical Reports Server (NTRS)

Paules, G.

1986-01-01

An Operations Management Concept developed by NASA for its Space Station Program is discussed. The operational goals, themes, and design principles established during program development are summarized. The major operations functions are described, including: space systems operations, user support operations, prelaunch/postlanding operations, logistics support operations, market research, and cost/financial management. Strategic, tactical, and execution levels of operational decision-making are defined.

40 CFR 62.14595 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., including types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, waste...

The measure and significance of Bateman's principles

PubMed Central

Collet, Julie M.; Dean, Rebecca F.; Worley, Kirsty; Richardson, David S.; Pizzari, Tommaso

2014-01-01

Bateman's principles explain sex roles and sexual dimorphism through sex-specific variance in mating success, reproductive success and their relationships within sexes (Bateman gradients). Empirical tests of these principles, however, have come under intense scrutiny. Here, we experimentally show that in replicate groups of red junglefowl, Gallus gallus, mating and reproductive successes were more variable in males than in females, resulting in a steeper male Bateman gradient, consistent with Bateman's principles. However, we use novel quantitative techniques to reveal that current methods typically overestimate Bateman's principles because they (i) infer mating success indirectly from offspring parentage, and thus miss matings that fail to result in fertilization, and (ii) measure Bateman gradients through the univariate regression of reproductive over mating success, without considering the substantial influence of other components of male reproductive success, namely female fecundity and paternity share. We also find a significant female Bateman gradient but show that this likely emerges as spurious consequences of male preference for fecund females, emphasizing the need for experimental approaches to establish the causal relationship between reproductive and mating success. While providing qualitative support for Bateman's principles, our study demonstrates how current approaches can generate a misleading view of sex differences and roles. PMID:24648220

Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

NASA Astrophysics Data System (ADS)

Jun, Suckjoon; Si, Fangwei; Pugatch, Rami; Scott, Matthew

2018-05-01

Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts. In the first part (sections 1–3), we review the first ‘golden era’ of bacterial physiology from the 1940s to early 1970s and provide a complete list of major references from that period. In the second part (sections 4–7), we explain how the pioneering work from the first golden era has influenced various rediscoveries of general quantitative principles and significant further development in modern bacterial physiology. Specifically, section 4 presents the history and current progress of the ‘adder’ principle of cell size homeostasis. Section 5 discusses the implications of coarse-graining the cellular protein composition, and how the coarse-grained proteome ‘sectors’ re-balance under different growth conditions. Section 6 focuses on physiological invariants, and explains how they are the key to understanding the coordination between growth and the cell cycle underlying cell size control in steady-state growth. Section 7 overviews how the temporal organization of all the internal processes enables balanced growth. In the final section 8, we conclude by discussing the remaining challenges for the future in the field.

Enlisting Madison Avenue: The Marketing Approach to Earning Popular Support in Theaters of Operation

DTIC Science & Technology

2007-01-01

equivalent size: 7 Philip Kotler and Gary Armstrong, Principles of Marketing, 11th ed., Upper Saddle River, N.J.: Pearson Education, 2006, p. 196. 8...researchers Philip Kotler , Ned Roberto, and Nancy Lee.146 To illus- trate the application of these steps in an operational theater, we utilize a...2003, p. 18. Kotler , Philip , and Gary Armstrong, Principles of Marketing, 11th ed., Upper Saddle River, N.J.: Pearson Education, 2006. 200

Air Base Ground Defense Wargame: Study of a Security Police Training Device.

DTIC Science & Technology

1987-09-01

different locations of the air base under siege. Therefore, AFOSP supports the development of a board wargame training device to compensate for the...commercial wargames available on the market . Eight games were identified as having application to this study due to their use of modern weapons and the...operation under his operational control (9:23). Concentration of MIR Efforts. This principle is a restatement of the universally accepted principle of mass (9

Quantitative site type delineation for pastures in the northeastern United States

USDA-ARS?s Scientific Manuscript database

The Grazing Lands component of the USDA-NRCS Conservation Effects Assessment Project (CEAP) is a national assessment of the environmental effects of management practices used on pasture and rangelands. The pasture subcomponent is based around applying ecological principles to temperate humid grazing...

Development of a nutrition education intervention for food bank clients

USDA-ARS?s Scientific Manuscript database

The focus of this article is the development of a nutrition education intervention for food bank clients. Formative research using mixed-methods (qualitative and quantitative) and community-based participatory research principles was conducted to assess the nutrition education needs of clients obtai...

Behavioral and neural Darwinism: selectionist function and mechanism in adaptive behavior dynamics.

PubMed

McDowell, J J

2010-05-01

An evolutionary theory of behavior dynamics and a theory of neuronal group selection share a common selectionist framework. The theory of behavior dynamics instantiates abstractly the idea that behavior is selected by its consequences. It implements Darwinian principles of selection, reproduction, and mutation to generate adaptive behavior in virtual organisms. The behavior generated by the theory has been shown to be quantitatively indistinguishable from that of live organisms. The theory of neuronal group selection suggests a mechanism whereby the abstract principles of the evolutionary theory may be implemented in the nervous systems of biological organisms. According to this theory, groups of neurons subserving behavior may be selected by synaptic modifications that occur when the consequences of behavior activate value systems in the brain. Together, these theories constitute a framework for a comprehensive account of adaptive behavior that extends from brain function to the behavior of whole organisms in quantitative detail. Copyright (c) 2009 Elsevier B.V. All rights reserved.

Quantitative analysis on electric dipole energy in Rashba band splitting.

PubMed

Hong, Jisook; Rhim, Jun-Won; Kim, Changyoung; Ryong Park, Seung; Hoon Shim, Ji

2015-09-01

We report on quantitative comparison between the electric dipole energy and the Rashba band splitting in model systems of Bi and Sb triangular monolayers under a perpendicular electric field. We used both first-principles and tight binding calculations on p-orbitals with spin-orbit coupling. First-principles calculation shows Rashba band splitting in both systems. It also shows asymmetric charge distributions in the Rashba split bands which are induced by the orbital angular momentum. We calculated the electric dipole energies from coupling of the asymmetric charge distribution and external electric field, and compared it to the Rashba splitting. Remarkably, the total split energy is found to come mostly from the difference in the electric dipole energy for both Bi and Sb systems. A perturbative approach for long wave length limit starting from tight binding calculation also supports that the Rashba band splitting originates mostly from the electric dipole energy difference in the strong atomic spin-orbit coupling regime.

Quantitative analysis on electric dipole energy in Rashba band splitting

PubMed Central

Hong, Jisook; Rhim, Jun-Won; Kim, Changyoung; Ryong Park, Seung; Hoon Shim, Ji

2015-01-01

We report on quantitative comparison between the electric dipole energy and the Rashba band splitting in model systems of Bi and Sb triangular monolayers under a perpendicular electric field. We used both first-principles and tight binding calculations on p-orbitals with spin-orbit coupling. First-principles calculation shows Rashba band splitting in both systems. It also shows asymmetric charge distributions in the Rashba split bands which are induced by the orbital angular momentum. We calculated the electric dipole energies from coupling of the asymmetric charge distribution and external electric field, and compared it to the Rashba splitting. Remarkably, the total split energy is found to come mostly from the difference in the electric dipole energy for both Bi and Sb systems. A perturbative approach for long wave length limit starting from tight binding calculation also supports that the Rashba band splitting originates mostly from the electric dipole energy difference in the strong atomic spin-orbit coupling regime. PMID:26323493

Quantitative (13)C Solid-State NMR Spectra by Multiple-Contact Cross-polarization for Drug Delivery: From Active Principles to Excipients and Drug Carriers.

PubMed

Saïdi, Fadila; Taulelle, Francis; Martineau, Charlotte

2016-08-01

In this contribution, we present an analysis of the main parameters influencing the efficiency of the (1)H → (13)C multiple-contact cross-polarization nuclear magnetic resonance (NMR) experiment in the context of solid pharmaceutical materials. Using the optimum experimental conditions, quantitative (13)C NMR spectra are then obtained for porous metal-organic frameworks (potential drug carriers) and for components present in drug formulations (active principle ingredient and excipients, amorphous or crystalline). Finally, we show that mixtures of components can also be quantified with this method and, hence, that it represents an ideal tool for quantification of pharmaceutical formulations by (13)C cross-polarization under magic-angle spinning NMR in the industry as it is robust and easy to set up, much faster than direct (13)C polarization and is efficient for samples at natural abundance. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

U.S. Military Information Operations in Afghanistan: Effectiveness of Psychological Operations 2001-2010

DTIC Science & Technology

2012-01-01

of target audiences in conflictive areas. Survey research can provide quantitative baselines and trend analyses of key attitudes held by the target...qualitative research , rather than quantitative . .  .  . The PRT [provincial reconstruction team] conducted mis- sions almost daily during the time frame it was...opposed to national-level polls, which might not be representative of target audiences in conflictive areas). Survey research can provide quantitative

BioCapacitor: A novel principle for biosensors.

PubMed

Sode, Koji; Yamazaki, Tomohiko; Lee, Inyoung; Hanashi, Takuya; Tsugawa, Wakako

2016-02-15

Studies regarding biofuel cells utilizing biocatalysts such as enzymes and microorganisms as electrocatalysts have been vigorously conducted over the last two decades. Because of their environmental safety and sustainability, biofuel cells are expected to be used as clean power generators. Among several principles of biofuel cells, enzyme fuel cells have attracted significant attention for their use as alternative energy sources for future implantable devices, such as implantable insulin pumps and glucose sensors in artificial pancreas and pacemakers. However, the inherent issue of the biofuel cell principle is the low power of a single biofuel cell. The theoretical voltage of biofuel cells is limited by the redox potential of cofactors and/or mediators employed in the anode and cathode, which are inadequate for operating any devices used for biomedical application. These limitations inspired us to develop a novel biodevice based on an enzyme fuel cell that generates sufficient stable power to operate electric devices, designated "BioCapacitor." To increase voltage, the enzyme fuel cell is connected to a charge pump. To obtain a sufficient power and voltage to operate an electric device, a capacitor is used to store the potential generated by the charge pump. Using the combination of a charge pump and capacitor with an enzyme fuel cell, high voltages with sufficient temporary currents to operate an electric device were generated without changing the design and construction of the enzyme fuel cell. In this review, the BioCapacitor principle is described. The three different representative categories of biodevices employing the BioCapacitor principle are introduced. Further, the recent challenges in the developments of self-powered stand-alone biodevices employing enzyme fuel cells combined with charge pumps and capacitors are introduced. Finally, the future prospects of biodevices employing the BioCapacitor principle are addressed. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

Principles and Procedures in Technical Assistance: An Approach to Educational Change

ERIC Educational Resources Information Center

Lillie, David L.; Black, Talbot

1976-01-01

The Technical Assistance Development System (TADS) has developed through the years a system for technical assistance and has identified some important principles that should be followed in the operation of organizational support systems. (Author/ER)

Design principles and operating principles: the yin and yang of optimal functioning.

PubMed

Voit, Eberhard O

2003-03-01

Metabolic engineering has as a goal the improvement of yield of desired products from microorganisms and cell lines. This goal has traditionally been approached with experimental biotechnological methods, but it is becoming increasingly popular to precede the experimental phase by a mathematical modeling step that allows objective pre-screening of possible improvement strategies. The models are either linear and represent the stoichiometry and flux distribution in pathways or they are non-linear and account for the full kinetic behavior of the pathway, which is often significantly effected by regulatory signals. Linear flux analysis is simpler and requires less input information than a full kinetic analysis, and the question arises whether the consideration of non-linearities is really necessary for devising optimal strategies for yield improvements. The article analyzes this question with a generic, representative pathway. It shows that flux split ratios, which are the key criterion for linear flux analysis, are essentially sufficient for unregulated, but not for regulated branch points. The interrelationships between regulatory design on one hand and optimal patterns of operation on the other suggest the investigation of operating principles that complement design principles, like a user's manual complements the hardwiring of electronic equipment.

Multi-scale Multi-mechanism Toughening of Hydrogels

NASA Astrophysics Data System (ADS)

Zhao, Xuanhe

Hydrogels are widely used as scaffolds for tissue engineering, vehicles for drug delivery, actuators for optics and fluidics, and model extracellular matrices for biological studies. The scope of hydrogel applications, however, is often severely limited by their mechanical properties. Inspired by the mechanics and hierarchical structures of tough biological tissues, we propose that a general principle for the design of tough hydrogels is to implement two mechanisms for dissipating mechanical energy and maintaining high elasticity in hydrogels. A particularly promising strategy for the design is to integrate multiple pairs of mechanisms across multiple length scales into a hydrogel. We develop a multiscale theoretical framework to quantitatively guide the design of tough hydrogels. On the network level, we have developed micro-physical models to characterize the evolution of polymer networks under deformation. On the continuum level, we have implemented constitutive laws formulated from the network-level models into a coupled cohesive-zone and Mullins-effect model to quantitatively predict crack propagation and fracture toughness of hydrogels. Guided by the design principle and quantitative model, we will demonstrate a set of new hydrogels, based on diverse types of polymers, yet can achieve extremely high toughness superior to their natural counterparts such as cartilages. The work was supported by NSF(No. CMMI- 1253495) and ONR (No. N00014-14-1-0528).

The organizational structure and governing principles of the Food and Drug Administration's Mini-Sentinel pilot program.

PubMed

Forrow, Susan; Campion, Daniel M; Herrinton, Lisa J; Nair, Vinit P; Robb, Melissa A; Wilson, Marcus; Platt, Richard

2012-01-01

The US Food and Drug Administration's Mini-Sentinel pilot program is developing an organizational structure as well as principles and policies to govern its operations. These will inform the structure and function of the eventual Sentinel System. Mini-Sentinel is a collaboration that includes 25 participating institutions. We describe the program's current organizational structure and its major principles and policies. The organization includes a coordinating center with program leadership provided by a principal investigator; a planning board and subcommittees; an operations center; and data, methods, and protocol cores. Ad hoc workgroups are created as needed. A privacy panel advises about protection of individual health information. Principles and policies are intended to ensure that Mini-Sentinel conforms to the principles of fair information practices, protects the privacy of individual health information, maintains the security and integrity of data, assures the confidentiality of proprietary information, provides accurate and timely communications, prevents or manages conflicts of interest, and preserves respect for intellectual property rights. Copyright © 2012 John Wiley & Sons, Ltd.

Uncertainty principle in loop quantum cosmology by Moyal formalism

NASA Astrophysics Data System (ADS)

Perlov, Leonid

2018-03-01

In this paper, we derive the uncertainty principle for the loop quantum cosmology homogeneous and isotropic Friedmann-Lemaiter-Robertson-Walker model with the holonomy-flux algebra. The uncertainty principle is between the variables c, with the meaning of connection and μ having the meaning of the physical cell volume to the power 2/3, i.e., v2 /3 or a plaquette area. Since both μ and c are not operators, but rather the random variables, the Robertson uncertainty principle derivation that works for hermitian operators cannot be used. Instead we use the Wigner-Moyal-Groenewold phase space formalism. The Wigner-Moyal-Groenewold formalism was originally applied to the Heisenberg algebra of the quantum mechanics. One can derive it from both the canonical and path integral quantum mechanics as well as the uncertainty principle. In this paper, we apply it to the holonomy-flux algebra in the case of the homogeneous and isotropic space. Another result is the expression for the Wigner function on the space of the cylindrical wave functions defined on Rb in c variables rather than in dual space μ variables.

Twelve Principles for Green Energy Storage in Grid Applications.

PubMed

Arbabzadeh, Maryam; Johnson, Jeremiah X; Keoleian, Gregory A; Rasmussen, Paul G; Thompson, Levi T

2016-01-19

The introduction of energy storage technologies to the grid could enable greater integration of renewables, improve system resilience and reliability, and offer cost effective alternatives to transmission and distribution upgrades. The integration of energy storage systems into the electrical grid can lead to different environmental outcomes based on the grid application, the existing generation mix, and the demand. Given this complexity, a framework is needed to systematically inform design and technology selection about the environmental impacts that emerge when considering energy storage options to improve sustainability performance of the grid. To achieve this, 12 fundamental principles specific to the design and grid application of energy storage systems are developed to inform policy makers, designers, and operators. The principles are grouped into three categories: (1) system integration for grid applications, (2) the maintenance and operation of energy storage, and (3) the design of energy storage systems. We illustrate the application of each principle through examples published in the academic literature, illustrative calculations, and a case study with an off-grid application of vanadium redox flow batteries (VRFBs). In addition, trade-offs that can emerge between principles are highlighted.

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XVIII, I--UNDERSTAND ENGINE GEARS AND GEARING PRINCIPLES, II--MACK INTER-AXLE POWER DIVIDER.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF DIESEL ENGINE GEARS AND GEARING PRINCIPLES AND THE OPERATING PRINCIPLES AND MAINTENANCE OF POWER DIVIDERS (GEAR BOXES) USED IN DIESEL ENGINE POWER TRANSMISSION. TOPICS ARE (1) THE PURPOSE OF THE ENGINE GEARS, (2) INSPECTING FOR GEAR FAILURES, (3) INSPECTING FOR SHAFT…

Potential scenarios of concern for high speed rail operations

DOT National Transportation Integrated Search

2011-03-16

Currently, multiple operating authorities are proposing the : introduction of high-speed rail service in the United States. : While high-speed rail service shares a number of basic : principles with conventional-speed rail service, the operational : ...

Principles of logic and the use of digital geographic information systems

USGS Publications Warehouse

Robinove, Charles Joseph

1986-01-01

Digital geographic information systems allow many different types of data to be spatially and statistically analyzed. Logical operations can be performed on individual or multiple data planes by algorithms that can be implemented in computer systems. Users and creators of the systems should fully understand these operations. This paper describes the relationships of layers and features in geographic data bases and the principles of logic that can be applied by geographic information systems and suggests that a thorough knowledge of the data that are entered into a geographic data base and of the logical operations will produce results that are most satisfactory to the user. Methods of spatial analysis are reduced to their primitive logical operations and explained to further such understanding.

A Tale of Two Community Networks Program Centers: Operationalizing and Assessing CBPR Principles and Evaluating Partnership Outcomes.

PubMed

Arroyo-Johnson, Cassandra; Allen, Michele L; Colditz, Graham A; Hurtado, G Ali; Davey, Cynthia S; Sanders Thompson, Vetta L; Drake, Bettina F; Svetaz, Maria Veronica; Rosas-Lee, Maira; Goodman, Melody S

2015-01-01

Community Networks Program (CNP) centers are required to use a community-based participatory research (CBPR) approach within their specific priority communities. Not all communities are the same and unique contextual factors and collaborators' priorities shape each CBPR partnership. There are also established CBPR and community engagement (CE) principles shown to lead to quality CBPR in any community. However, operationalizing and assessing CBPR principles and partnership outcomes to understand the conditions and processes in CBPR that lead to achieving program and project level goals is relatively new in the science of CBPR. We sought to describe the development of surveys on adherence to and implementation of CBPR/CE principles at two CNP centers and examine commonalities and differences in program-versus project-level CBPR evaluation. A case study about the development and application of CBPR/CE principles for the Missouri CNP, Program for the Elimination of Cancer Disparities, and Minnesota CNP, Padres Informados/Jovenes Preparados, surveys was conducted to compare project versus program operationalization of principles. Survey participant demographics were provided by CNP. Specific domains found in CBPR/CE principles were identified and organized under an existing framework to establish a common ground. Operational definitions and the number of survey items were provided for each domain by CNP. There are distinct differences in operational definitions of CBPR/CE principles at the program and project levels of evaluation. However, commonalities support further research to develop standards for CBPR evaluation across partnerships and at the program and project levels.

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

CellShape: A user-friendly image analysis tool for quantitative visualization of bacterial cell factories inside.

PubMed

Goñi-Moreno, Ángel; Kim, Juhyun; de Lorenzo, Víctor

2017-02-01

Visualization of the intracellular constituents of individual bacteria while performing as live biocatalysts is in principle doable through more or less sophisticated fluorescence microscopy. Unfortunately, rigorous quantitation of the wealth of data embodied in the resulting images requires bioinformatic tools that are not widely extended within the community-let alone that they are often subject to licensing that impedes software reuse. In this context we have developed CellShape, a user-friendly platform for image analysis with subpixel precision and double-threshold segmentation system for quantification of fluorescent signals stemming from single-cells. CellShape is entirely coded in Python, a free, open-source programming language with widespread community support. For a developer, CellShape enhances extensibility (ease of software improvements) by acting as an interface to access and use existing Python modules; for an end-user, CellShape presents standalone executable files ready to open without installation. We have adopted this platform to analyse with an unprecedented detail the tridimensional distribution of the constituents of the gene expression flow (DNA, RNA polymerase, mRNA and ribosomal proteins) in individual cells of the industrial platform strain Pseudomonas putida KT2440. While the CellShape first release version (v0.8) is readily operational, users and/or developers are enabled to expand the platform further. Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Risk analysis of heat recovery steam generator with semi quantitative risk based inspection API 581

NASA Astrophysics Data System (ADS)

Prayogo, Galang Sandy; Haryadi, Gunawan Dwi; Ismail, Rifky; Kim, Seon Jin

2016-04-01

Corrosion is a major problem that most often occurs in the power plant. Heat recovery steam generator (HRSG) is an equipment that has a high risk to the power plant. The impact of corrosion damage causing HRSG power plant stops operating. Furthermore, it could be threaten the safety of employees. The Risk Based Inspection (RBI) guidelines by the American Petroleum Institute (API) 58 has been used to risk analysis in the HRSG 1. By using this methodology, the risk that caused by unexpected failure as a function of the probability and consequence of failure can be estimated. This paper presented a case study relating to the risk analysis in the HRSG, starting with a summary of the basic principles and procedures of risk assessment and applying corrosion RBI for process industries. The risk level of each HRSG equipment were analyzed: HP superheater has a medium high risk (4C), HP evaporator has a medium-high risk (4C), and the HP economizer has a medium risk (3C). The results of the risk assessment using semi-quantitative method of standard API 581 based on the existing equipment at medium risk. In the fact, there is no critical problem in the equipment components. Damage mechanisms were prominent throughout the equipment is thinning mechanism. The evaluation of the risk approach was done with the aim of reducing risk by optimizing the risk assessment activities.

Spent lead-acid battery recycling in China - A review and sustainable analyses on mass flow of lead.

PubMed

Sun, Zhi; Cao, Hongbin; Zhang, Xihua; Lin, Xiao; Zheng, Wenwen; Cao, Guoqing; Sun, Yong; Zhang, Yi

2017-06-01

Lead is classified to be one of the top heavy metal pollutants in China. The corresponding environmental issues especially during the management of spent lead-acid battery have already caused significant public awareness and concern. This research gives a brief overview on the recycling situation based on an investigation of the lead industry in China and also the development of technologies for spent lead-acid batteries. The main principles and research focuses of different technologies including pyrometallurgy, hydrometallurgy and greener technologies are summarized and compared. Subsequently, the circulability of lead based on the entire life cycle analyses of lead-acid battery is calculated. By considering different recycling schemes, the recycling situation of spent lead-acid battery in China can be understood semi-quantitatively. According to this research, 30% of the primary lead production can be shut down that the lead production can still ensure consecutive life cycle operation of lead-acid battery, if proper management of the spent lead-acid battery is implemented according to current lead industry situation in China. This research provides a methodology on the view of lead circulability in the whole life cycle of a specific product and is aiming to contribute more quantitative guidelines for efficient organization of lead industry in China. Copyright © 2017 Elsevier Ltd. All rights reserved.

TROSY-based z-exchange spectroscopy: application to the determination of the activation energy for intermolecular protein translocation between specific sites on different DNA molecules.

PubMed

Sahu, Debashish; Clore, G Marius; Iwahara, Junji

2007-10-31

A two-dimensional TROSY-based z-exchange 1H-15N correlation experiment for the quantitative analysis of kinetic processes in the slow exchange regime is presented. The pulse scheme converts the product operator terms Nz into 2NzHz and 2NzHz into -Nz in the middle of the z-mixing period, thereby suppressing the buildup of spurious semi-TROSY peaks arising from the different relaxation rates for the Nz and 2NzHz terms and simplifying the behavior of longitudinal magnetization for an exchanging system during the mixing period. Theoretical considerations and experimental data demonstrate that the TROSY-based z-exchange experiment permits quantitative determination of rate constants using the same procedure as that for the conventional non-TROSY 15Nz-exchange experiment. Line narrowing as a consequence of the use of the TROSY principle makes the method particularly suitable for kinetic studies at low temperature, thereby permitting activation energies to be extracted from data acquired over a wider temperature range. We applied this method to the investigation of the process whereby the HoxD9 homeodomain translocates between specific target sites on different DNA molecules via a direct transfer mechanism without going through the intermediary of free protein. The activation enthalpy for intermolecular translocation was determined to be 17 kcal/mol.

Kinesthetic Activities for the Classroom

NASA Astrophysics Data System (ADS)

Mylott, Elliot; Dunlap, Justin; Lampert, Lester; Widenhorn, Ralf

2014-12-01

Educators have found that kinesthetic involvement in an experiment or demonstration can engage students in a powerful way.1-3 With that as our goal, we developed three activities that allow students to connect with and quantitatively explore key physics principles from mechanics with three fun physical challenges. By presenting these activities as competitions, we can challenge students to use what they know about the relevant physics to improve their performance and beat their own score or those of other students. Each activity uses an original, real-time data collecting program that offers students and educators a simple, clear method to demonstrate various physics concepts including: (1) impulse momentum, (2) center of mass (COM), and (3) kinematics. The user interface, written in LabVIEW, is intuitive to operate and only requires Vernier Force Plates,4 a Vernier LabQuest,5 a webcam, and a computer. In this article, we will describe each of these activities, all of which are well suited and readily available for other outreach events or classroom demonstrations.

An in silico algal toxicity model with a wide applicability potential for industrial chemicals and pharmaceuticals.

PubMed

Önlü, Serli; Saçan, Melek Türker

2017-04-01

The authors modeled the 72-h algal toxicity data of hundreds of chemicals with different modes of action as a function of chemical structures. They developed mode of action-based local quantitative structure-toxicity relationship (QSTR) models for nonpolar and polar narcotics as well as a global QSTR model with a wide applicability potential for industrial chemicals and pharmaceuticals. The present study rigorously evaluated the generated models, meeting the Organisation for Economic Co-operation and Development principles of robustness, validity, and transparency. The proposed global model had a broad structural coverage for the toxicity prediction of diverse chemicals (some of which are high-production volume chemicals) with no experimental toxicity data. The global model is potentially useful for endpoint predictions, the evaluation of algal toxicity screening, and the prioritization of chemicals, as well as for the decision of further testing and the development of risk-management measures in a scientific and regulatory frame. Environ Toxicol Chem 2017;36:1012-1019. © 2016 SETAC. © 2016 SETAC.

Materials Science Laboratory - Columnar-to-Equiaxed Transition in Solidification Processing and Microstructure Formation in Casting of Technical Alloys under Diffusive and Magnetically Controlled Convective Conditions

NASA Technical Reports Server (NTRS)

Gandin, Charles-Andre; Ratke, Lorenz

2008-01-01

The Materials Science Laboratory - Columnar-to-Equiaxed Transition in Solidification Processing and Microstructure Formation in Casting of Technical Alloys under Diffusive and Magnetically Controlled Convective Conditions (MSL-CETSOL and MICAST) are two investigations which supports research into metallurgical solidification, semiconductor crystal growth (Bridgman and zone melting), and measurement of thermo-physical properties of materials. This is a cooperative investigation with the European Space Agency (ESA) and National Aeronautics and Space Administration (NASA) for accommodation and operation aboard the International Space Station (ISS). Research Summary: Materials Science Laboratory - Columnar-to-Equiaxed Transition in Solidification Processing (CETSOL) and Microstructure Formation in Casting of Technical Alloys under Diffusive and Magnetically Controlled Convective Conditions (MICAST) are two complementary investigations which will examine different growth patterns and evolution of microstructures during crystallization of metallic alloys in microgravity. The aim of these experiments is to deepen the quantitative understanding of the physical principles that govern solidification processes in cast alloys by directional solidification.

Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum

DOE PAGES

Shin, Jae Yen; Lopez-Garrido, Javier; Lee, Sang-Hyuk; ...

2015-05-07

SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to mediate chromosome translocation and membrane fission during Bacillus subtilis sporulation. Here we use cell-specific protein degradation and quantitative photoactivated localization microscopy in strains with a thick sporulation septum to investigate the architecture and function of the SpoIIIE DNA translocation complex in vivo. We were able to visualize SpoIIIE complexes with approximately equal numbers of molecules in the mother cell and the forespore. Cell-specific protein degradation showed that only the mother cell complex is required to translocate DNA into the forespore, whereas degradation in either cell reverses membranemore » fission. Our data suggest that SpoIIIE assembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to maintain membrane fission during DNA translocation. We show that SpoIIIE can operate, in principle, as a bi-directional motor that exports DNA.« less

Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shin, Jae Yen; Lopez-Garrido, Javier; Lee, Sang-Hyuk

SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to mediate chromosome translocation and membrane fission during Bacillus subtilis sporulation. Here we use cell-specific protein degradation and quantitative photoactivated localization microscopy in strains with a thick sporulation septum to investigate the architecture and function of the SpoIIIE DNA translocation complex in vivo. We were able to visualize SpoIIIE complexes with approximately equal numbers of molecules in the mother cell and the forespore. Cell-specific protein degradation showed that only the mother cell complex is required to translocate DNA into the forespore, whereas degradation in either cell reverses membranemore » fission. Our data suggest that SpoIIIE assembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to maintain membrane fission during DNA translocation. We show that SpoIIIE can operate, in principle, as a bi-directional motor that exports DNA.« less

Structured illumination microscopy for dual-modality 3D sub-diffraction resolution fluorescence and refractive-index reconstruction

PubMed Central

Chowdhury, Shwetadwip; Eldridge, Will J.; Wax, Adam; Izatt, Joseph A.

2017-01-01

Though structured illumination (SI) microscopy is a popular imaging technique conventionally associated with fluorescent super-resolution, recent works have suggested its applicability towards sub-diffraction resolution coherent imaging with quantitative endogenous biological contrast. Here, we demonstrate that SI can efficiently integrate together the principles of fluorescent super-resolution and coherent synthetic aperture to achieve 3D dual-modality sub-diffraction resolution, fluorescence and refractive-index (RI) visualizations of biological samples. We experimentally demonstrate this framework by introducing a SI microscope capable of 3D sub-diffraction resolution fluorescence and RI imaging, and verify its biological visualization capabilities by experimentally reconstructing 3D RI/fluorescence visualizations of fluorescent calibration microspheres as well as alveolar basal epithelial adenocarcinoma (A549) and human colorectal adenocarcinmoa (HT-29) cells, fluorescently stained for F-actin. This demonstration may suggest SI as an especially promising imaging technique to enable future biological studies that explore synergistically operating biophysical/biochemical and molecular mechanisms at sub-diffraction resolutions. PMID:29296504

Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species.

PubMed

Yoshinobu, Tatsuo; Miyamoto, Ko-Ichiro; Werner, Carl Frederik; Poghossian, Arshak; Wagner, Torsten; Schöning, Michael J

2017-06-12

A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.

Elevated atmospheric carbon dioxide concentrations amplify Alternaria alternata sporulation and total antigen production

USDA-ARS?s Scientific Manuscript database

Background: Although the association between rising levels of carbon dioxide, the principle anthropogenic greenhouse gas, and pollen production has been established, few data are available regarding the function of rising carbon dioxide on quantitative or qualitative changes in allergenic fungal sp...

Behavioral Economics and Empirical Public Policy

ERIC Educational Resources Information Center

Hursh, Steven R.; Roma, Peter G.

2013-01-01

The application of economics principles to the analysis of behavior has yielded novel insights on value and choice across contexts ranging from laboratory animal research to clinical populations to national trends of global impact. Recent innovations in demand curve methods provide a credible means of quantitatively comparing qualitatively…

Structured decision making as a framework for linking quantitative decision support to community values

EPA Science Inventory

Community-level decisions can have large impacts on production and delivery of ecosystem services, which ultimately affects community well-being. But engaging stakeholders in a process to explore these impacts is a significant challenge. The principles of Structured Decision Ma...

An Examination of Effective Professional Development Characteristics in Professional Learning Communities

ERIC Educational Resources Information Center

Strickland, Crystal Y.

2013-01-01

The purpose of this quantitative study was to investigate the extent to which professional development practices in professional learning communities are consistent with research-based principles of effective professional development. Additionally, the study investigated potential differences in the content focus, active learning, coherence, and…

Investigating Evolution with Living Plants.

ERIC Educational Resources Information Center

Schlessman, Mark A.

1997-01-01

Describes two investigative labs that use live plants to illustrate important biological principles, include quantitative analysis, and require very little equipment. Each lab is adaptable to a variety of class sizes, course contents, and student backgrounds. Topics include the evolution of flower size in Mimulus and pollination of Brassicas. (DDR)

John Stuart Mill's Concepts of Quality and Pedagogical Norms.

ERIC Educational Resources Information Center

Kim, Ki Su

1986-01-01

Considers the paradoxical relationship between two pervasive educational goals--quality and equality. Sees this paradox embedded in John Stuart Mill's writings on education, which attempted to reconcile the utilitarian pleasure principle (which emphasizes quantitative measures), with a traditional differentiation among levels and kinds of desires…

Production of photocurrent due to intermediate-to-conduction-band transitions: a demonstration of a key operating principle of the intermediate-band solar cell.

PubMed

Martí, A; Antolín, E; Stanley, C R; Farmer, C D; López, N; Díaz, P; Cánovas, E; Linares, P G; Luque, A

2006-12-15

We present intermediate-band solar cells manufactured using quantum dot technology that show for the first time the production of photocurrent when two sub-band-gap energy photons are absorbed simultaneously. One photon produces an optical transition from the intermediate-band to the conduction band while the second pumps an electron from the valence band to the intermediate-band. The detection of this two-photon absorption process is essential to verify the principles of operation of the intermediate-band solar cell. The phenomenon is the cornerstone physical principle that ultimately allows the production of photocurrent in a solar cell by below band gap photon absorption, without degradation of its output voltage.

Exploring the Dynamics and Modeling National Budget as a Supply Chain System: A Proposal for Reengineering the Budgeting Process and for Developing a Management Flight Simulator

DTIC Science & Technology

2012-09-01

Elmendorf, D. W., & Gregory Mankiw , N. (1999). Government debt. Handbook of Macroeconomics , 1, 1615-1669. European Union. European financial stability...budget process, based on the supply chain demand management process principles of operations and it is introduced the idea of developing a Budget... principles of systems dynamics, a proposal for the development of a Budget Management Flight Simulator, that will operate as a learning and educational

The four principles: Can they be measured and do they predict ethical decision making?

PubMed Central

2012-01-01

Background The four principles of Beauchamp and Childress - autonomy, non-maleficence, beneficence and justice - have been extremely influential in the field of medical ethics, and are fundamental for understanding the current approach to ethical assessment in health care. This study tests whether these principles can be quantitatively measured on an individual level, and then subsequently if they are used in the decision making process when individuals are faced with ethical dilemmas. Methods The Analytic Hierarchy Process was used as a tool for the measurement of the principles. Four scenarios, which involved conflicts between the medical ethical principles, were presented to participants who then made judgments about the ethicality of the action in the scenario, and their intentions to act in the same manner if they were in the situation. Results Individual preferences for these medical ethical principles can be measured using the Analytic Hierarchy Process. This technique provides a useful tool in which to highlight individual medical ethical values. On average, individuals have a significant preference for non-maleficence over the other principles, however, and perhaps counter-intuitively, this preference does not seem to relate to applied ethical judgements in specific ethical dilemmas. Conclusions People state they value these medical ethical principles but they do not actually seem to use them directly in the decision making process. The reasons for this are explained through the lack of a behavioural model to account for the relevant situational factors not captured by the principles. The limitations of the principles in predicting ethical decision making are discussed. PMID:22606995

The four principles: can they be measured and do they predict ethical decision making?

PubMed

Page, Katie

2012-05-20

The four principles of Beauchamp and Childress--autonomy, non-maleficence, beneficence and justice--have been extremely influential in the field of medical ethics, and are fundamental for understanding the current approach to ethical assessment in health care. This study tests whether these principles can be quantitatively measured on an individual level, and then subsequently if they are used in the decision making process when individuals are faced with ethical dilemmas. The Analytic Hierarchy Process was used as a tool for the measurement of the principles. Four scenarios, which involved conflicts between the medical ethical principles, were presented to participants who then made judgments about the ethicality of the action in the scenario, and their intentions to act in the same manner if they were in the situation. Individual preferences for these medical ethical principles can be measured using the Analytic Hierarchy Process. This technique provides a useful tool in which to highlight individual medical ethical values. On average, individuals have a significant preference for non-maleficence over the other principles, however, and perhaps counter-intuitively, this preference does not seem to relate to applied ethical judgements in specific ethical dilemmas. People state they value these medical ethical principles but they do not actually seem to use them directly in the decision making process. The reasons for this are explained through the lack of a behavioural model to account for the relevant situational factors not captured by the principles. The limitations of the principles in predicting ethical decision making are discussed.

40 CFR 60.2635 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Environmental concerns, including types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, waste charging, and shutdown procedures. (iv) Combustion controls and monitoring. (v) Operation...

40 CFR 60.2070 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Environmental concerns, including types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, waste charging, and shutdown procedures. (iv) Combustion controls and monitoring. (v) Operation...

Development, characterization, and modeling of a tunable filter camera

NASA Astrophysics Data System (ADS)

Sartor, Mark Alan

1999-10-01

This paper describes the development, characterization, and modeling of a Tunable Filter Camera (TFC). The TFC is a new multispectral instrument with electronically tuned spectral filtering and low-light-level sensitivity. It represents a hybrid between hyperspectral and multispectral imaging spectrometers that incorporates advantages from each, addressing issues such as complexity, cost, lack of sensitivity, and adaptability. These capabilities allow the TFC to be applied to low- altitude video surveillance for real-time spectral and spatial target detection and image exploitation. Described herein are the theory and principles of operation for the TFC, which includes a liquid crystal tunable filter, an intensified CCD, and a custom apochromatic lens. The results of proof-of-concept testing, and characterization of two prototype cameras are included, along with a summary of the design analyses for the development of a multiple-channel system. A significant result of this effort was the creation of a system-level model, which was used to facilitate development and predict performance. It includes models for the liquid crystal tunable filter and intensified CCD. Such modeling was necessary in the design of the system and is useful for evaluation of the system in remote-sensing applications. Also presented are characterization data from component testing, which included quantitative results for linearity, signal to noise ratio (SNR), linearity, and radiometric response. These data were used to help refine and validate the model. For a pre-defined source, the spatial and spectral response, and the noise of the camera, system can now be predicted. The innovation that sets this development apart is the fact that this instrument has been designed for integrated, multi-channel operation for the express purpose of real-time detection/identification in low- light-level conditions. Many of the requirements for the TFC were derived from this mission. In order to provide background for the design requirements for the TFC development, the mission and principles of operation behind the multi-channel system will be reviewed. Given the combination of the flexibility, simplicity, and sensitivity, the TFC and its multiple-channel extension can play a significant role in the next generation of remote-sensing instruments.

Autonomous intelligent cars: proof that the EPSRC Principles are future-proof

NASA Astrophysics Data System (ADS)

de Cock Buning, Madeleine; de Bruin, Roeland

2017-07-01

Principle 2 of the EPSRC's principles of robotics (AISB workshop on Principles of Robotics, 2016) proves to be future proof when applied to the current state of the art of law and technology surrounding autonomous intelligent cars (AICs). Humans, not AICS, are responsible agents. AICs should be designed; operated as far as is practicable to comply with existing laws and fundamental rights and freedoms, including privacy by design. It will show that some legal questions arising from autonomous intelligent driving technology can be answered by the technology itself.

Assessment of and standardization for quantitative nondestructive test

NASA Technical Reports Server (NTRS)

Neuschaefer, R. W.; Beal, J. B.

1972-01-01

Present capabilities and limitations of nondestructive testing (NDT) as applied to aerospace structures during design, development, production, and operational phases are assessed. It will help determine what useful structural quantitative and qualitative data may be provided from raw materials to vehicle refurbishment. This assessment considers metal alloys systems and bonded composites presently applied in active NASA programs or strong contenders for future use. Quantitative and qualitative data has been summarized from recent literature, and in-house information, and presented along with a description of those structures or standards where the information was obtained. Examples, in tabular form, of NDT technique capabilities and limitations have been provided. NDT techniques discussed and assessed were radiography, ultrasonics, penetrants, thermal, acoustic, and electromagnetic. Quantitative data is sparse; therefore, obtaining statistically reliable flaw detection data must be strongly emphasized. The new requirements for reusable space vehicles have resulted in highly efficient design concepts operating in severe environments. This increases the need for quantitative NDT evaluation of selected structural components, the end item structure, and during refurbishment operations.

Business Management for Independent Schools. Third Edition.

ERIC Educational Resources Information Center

National Association of Independent Schools, Boston, MA.

This business management manual discusses school accounting and reporting principles; in particular, financial management, computerization, and records retention techniques. First is described the basic accounting principles, plant funds, endowment funds, operational funds, chart of accounts, and financial states of the school's annual financial…

Organizing for Sustainability

ERIC Educational Resources Information Center

Brown, William M.; Hamburger, Michael W.

2012-01-01

A successful campus sustainability effort catalyzes broad engagement of the campus community and integration of sustainability principles into the academic and operational components of campus life. Although many universities have embraced sustainability as a new core value, others have been more sluggish in adopting sustainability principles to…

48 CFR 852.211-70 - Service data manuals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... applicable, flow charts and narrative descriptions of software shall be provided. If programming is either...) Section IV, Principles of Operation. This section shall describe in narrative form the principles of... the recommended frequency of performance shall be included for visual inspection, cleaning...

Human error identification for laparoscopic surgery: Development of a motion economy perspective.

PubMed

Al-Hakim, Latif; Sevdalis, Nick; Maiping, Tanaphon; Watanachote, Damrongpan; Sengupta, Shomik; Dissaranan, Charuspong

2015-09-01

This study postulates that traditional human error identification techniques fail to consider motion economy principles and, accordingly, their applicability in operating theatres may be limited. This study addresses this gap in the literature with a dual aim. First, it identifies the principles of motion economy that suit the operative environment and second, it develops a new error mode taxonomy for human error identification techniques which recognises motion economy deficiencies affecting the performance of surgeons and predisposing them to errors. A total of 30 principles of motion economy were developed and categorised into five areas. A hierarchical task analysis was used to break down main tasks of a urological laparoscopic surgery (hand-assisted laparoscopic nephrectomy) to their elements and the new taxonomy was used to identify errors and their root causes resulting from violation of motion economy principles. The approach was prospectively tested in 12 observed laparoscopic surgeries performed by 5 experienced surgeons. A total of 86 errors were identified and linked to the motion economy deficiencies. Results indicate the developed methodology is promising. Our methodology allows error prevention in surgery and the developed set of motion economy principles could be useful for training surgeons on motion economy principles. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Quantitative determination of testosterone levels with biolayer interferometry.

PubMed

Zhang, Hao; Li, Wei; Luo, Hong; Xiong, Guangming; Yu, Yuanhua

2017-10-01

Natural and synthetic steroid hormones are widely spread in the environment and are considered as pollutants due to their endocrine activities, even at low concentrations, which are harmful to human health. To detect steroid hormones in the environment, a novel biosensor system was developed based on the principle of biolayer interferometry. Detection is based on changes in the interference pattern of white light reflected from the surface of an optical fiber with bound biomolecules. Monitoring interactions between molecules does not require radioactive, enzymatic, or fluorescent labels. Here, 2 double-stranded DNA fragments of operator 1 (OP1) and OP2 containing 10-bp palindromic sequences in chromosomal Comamonas testosteroni DNA (ATCC11996) were surface-immobilized to streptavidin sensors. Interference changes were detected when repressor protein RepA bound the DNA sequences. DNA-protein interactions were characterized and kinetic parameters were obtained. The dissociation constants between the OP1 and OP2 DNA sequences and RepA were 9.865 × 10 -9  M and 2.750 × 10 -8  M, respectively. The reactions showed high specifically and affinity. Because binding of the 10-bp palindromic sequence and RepA was affected by RepA-testosterone binding, the steroid could be quantitatively determined rapidly using the biosensor system. The mechanism of the binding assay was as follows. RepA could bind both OP1 and testosterone. RepA binding to testosterone changed the protein conformation, which influenced the binding between RepA and OP1. The percentage of the signal detected negative correlation with the testosterone concentration. A standard curve was obtained, and the correlation coefficient value was approximately 0.97. We could quantitatively determine testosterone levels between 2.13 and 136.63 ng/ml. Each sample could be quantitatively detected in 17 min. These results suggested that the specific interaction between double-stranded OP1 DNA and the RepA protein could be used to rapidly and quantitatively determine environmental testosterone levels by the biolayer interferometry technique. Copyright © 2017 Elsevier B.V. All rights reserved.

Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03281a

PubMed Central

Shah, Kavit; Bentley, Emma; Tyler, Adam; Richards, Kevin S. R.; Wright, Edward; Easterbrook, Linda; Lee, Diane; Cleaver, Claire; Usher, Louise; Burton, Jane E.; Pitman, James K.; Bruce, Christine B.; Edge, David; Lee, Martin; Nazareth, Nelson; Norwood, David A.

2017-01-01

The West African Ebola virus outbreak underlined the importance of delivering mass diagnostic capability outside the clinical or primary care setting in effectively containing public health emergencies caused by infectious disease. Yet, to date, there is no solution for reliably deploying at the point of need the gold standard diagnostic method, real time quantitative reverse transcription polymerase chain reaction (RT-qPCR), in a laboratory infrastructure-free manner. In this proof of principle work, we demonstrate direct performance of RT-qPCR on fresh blood using far-red fluorophores to resolve fluorogenic signal inhibition and controlled, rapid freeze/thawing to achieve viral genome extraction in a single reaction chamber assay. The resulting process is entirely free of manual or automated sample pre-processing, requires no microfluidics or magnetic/mechanical sample handling and thus utilizes low cost consumables. This enables a fast, laboratory infrastructure-free, minimal risk and simple standard operating procedure suited to frontline, field use. Developing this novel approach on recombinant bacteriophage and recombinant human immunodeficiency virus (HIV; Lentivirus), we demonstrate clinical utility in symptomatic EBOV patient screening using live, infectious Filoviruses and surrogate patient samples. Moreover, we evidence assay co-linearity independent of viral particle structure that may enable viral load quantification through pre-calibration, with no loss of specificity across an 8 log-linear maximum dynamic range. The resulting quantitative rapid identification (QuRapID) molecular diagnostic platform, openly accessible for assay development, meets the requirements of resource-limited countries and provides a fast response solution for mass public health screening against emerging biosecurity threats. PMID:29163915

Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography

PubMed Central

Pauling, Linus; Robinson, Arthur B.; Teranishi, Roy; Cary, Paul

1971-01-01

When a human being is placed for several days on a completely defined diet, consisting almost entirely of small molecules that are absorbed from the stomach into the blood, intestinal flora disappear because of lack of nutrition. By this technique, the composition of body fluids can be made constant (standard deviation about 10%) after a few days, permitting significant quantitative analyses to be performed. A method of temperature-programmed gas-liquid partition chromatography has been developed for this purpose. It permits the quantitative determination of about 250 substances in a sample of breath, and of about 280 substances in a sample of urine vapor. The technique should be useful in the application of the principles of orthomolecular medicine. PMID:5289873

Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography.

PubMed

Pauling, L; Robinson, A B; Teranishi, R; Cary, P

1971-10-01

When a human being is placed for several days on a completely defined diet, consisting almost entirely of small molecules that are absorbed from the stomach into the blood, intestinal flora disappear because of lack of nutrition. By this technique, the composition of body fluids can be made constant (standard deviation about 10%) after a few days, permitting significant quantitative analyses to be performed. A method of temperature-programmed gas-liquid partition chromatography has been developed for this purpose. It permits the quantitative determination of about 250 substances in a sample of breath, and of about 280 substances in a sample of urine vapor. The technique should be useful in the application of the principles of orthomolecular medicine.

Quantification of Microbial Phenotypes

PubMed Central

Martínez, Verónica S.; Krömer, Jens O.

2016-01-01

Metabolite profiling technologies have improved to generate close to quantitative metabolomics data, which can be employed to quantitatively describe the metabolic phenotype of an organism. Here, we review the current technologies available for quantitative metabolomics, present their advantages and drawbacks, and the current challenges to generate fully quantitative metabolomics data. Metabolomics data can be integrated into metabolic networks using thermodynamic principles to constrain the directionality of reactions. Here we explain how to estimate Gibbs energy under physiological conditions, including examples of the estimations, and the different methods for thermodynamics-based network analysis. The fundamentals of the methods and how to perform the analyses are described. Finally, an example applying quantitative metabolomics to a yeast model by 13C fluxomics and thermodynamics-based network analysis is presented. The example shows that (1) these two methods are complementary to each other; and (2) there is a need to take into account Gibbs energy errors. Better estimations of metabolic phenotypes will be obtained when further constraints are included in the analysis. PMID:27941694

Quantitation without Calibration: Response Profile as an Indicator of Target Amount.

PubMed

Debnath, Mrittika; Farace, Jessica M; Johnson, Kristopher D; Nesterova, Irina V

2018-06-21

Quantitative assessment of biomarkers is essential in numerous contexts from decision-making in clinical situations to food quality monitoring to interpretation of life-science research findings. However, appropriate quantitation techniques are not as widely addressed as detection methods. One of the major challenges in biomarker's quantitation is the need to have a calibration for correlating a measured signal to a target amount. The step complicates the methodologies and makes them less sustainable. In this work we address the issue via a new strategy: relying on position of response profile rather than on an absolute signal value for assessment of a target's amount. In order to enable the capability we develop a target-probe binding mechanism based on a negative cooperativity effect. A proof-of-concept example demonstrates that the model is suitable for quantitative analysis of nucleic acids over a wide concentration range. The general principles of the platform will be applicable toward a variety of biomarkers such as nucleic acids, proteins, peptides, and others.

A computational model of selection by consequences: log survivor plots.

PubMed

Kulubekova, Saule; McDowell, J J

2008-06-01

[McDowell, J.J, 2004. A computational model of selection by consequences. J. Exp. Anal. Behav. 81, 297-317] instantiated the principle of selection by consequences in a virtual organism with an evolving repertoire of possible behaviors undergoing selection, reproduction, and mutation over many generations. The process is based on the computational approach, which is non-deterministic and rules-based. The model proposes a causal account for operant behavior. McDowell found that the virtual organism consistently showed a hyperbolic relationship between response and reinforcement rates according to the quantitative law of effect. To continue validation of the computational model, the present study examined its behavior on the molecular level by comparing the virtual organism's IRT distributions in the form of log survivor plots to findings from live organisms. Log survivor plots did not show the "broken-stick" feature indicative of distinct bouts and pauses in responding, although the bend in slope of the plots became more defined at low reinforcement rates. The shape of the virtual organism's log survivor plots was more consistent with the data on reinforced responding in pigeons. These results suggest that log survivor plot patterns of the virtual organism were generally consistent with the findings from live organisms providing further support for the computational model of selection by consequences as a viable account of operant behavior.

QUANTITATIVE DECISION TOOLS AND MANAGEMENT DEVELOPMENT PROGRAMS.

ERIC Educational Resources Information Center

BYARS, LLOYD L.; NUNN, GEOFFREY E.

THIS ARTICLE OUTLINED THE CURRENT STATUS OF QUANTITATIVE METHODS AND OPERATIONS RESEARCH (OR), SKETCHED THE STRENGTHS OF TRAINING EFFORTS AND ISOLATED WEAKNESSES, AND FORMULATED WORKABLE CRITERIA FOR EVALUATING SUCCESS OF OPERATIONS RESEARCH TRAINING PROGRAMS. A SURVEY OF 105 COMPANIES REVEALED THAT PERT, INVENTORY CONTROL THEORY AND LINEAR…

Reconfigurable manufacturing systems: Principles, design, and future trends

NASA Astrophysics Data System (ADS)

Koren, Yoram; Gu, Xi; Guo, Weihong

2018-06-01

Reconfigurable manufacturing systems (RMSs), which possess the advantages of both dedicated serial lines and flexible manufacturing systems, were introduced in the mid-1990s to address the challenges initiated by globalization. The principal goal of an RMS is to enhance the responsiveness of manufacturing systems to unforeseen changes in product demand. RMSs are costeffective because they boost productivity, and increase the lifetime of the manufacturing system. Because of the many streams in which a product may be produced on an RMS, maintaining product precision in an RMS is a challenge. But the experience with RMS in the last 20 years indicates that product quality can be definitely maintained by inserting in-line inspection stations. In this paper, we formulate the design and operational principles for RMSs, and provide a state-of-the-art review of the design and operations methodologies of RMSs according to these principles. Finally, we propose future research directions, and deliberate on how recent intelligent manufacturing technologies may advance the design and operations of RMSs.

Zebrafish Housing Systems: A Review of Basic Operating Principles and Considerations for Design and Functionality

PubMed Central

Lawrence, Christian; Mason, Timothy

2015-01-01

The strategies for housing zebrafish used in biomedical research have evolved considerably over the past three decades. To keep pace with the rapid expansion and development of the zebrafish model system, the field has generally moved from keeping fish at the level of aquarium hobbyist to that of industrialized, recirculating aquaculture. Numerous commercial system vendors now offer increasingly sophisticated housing systems based on design principles that maximize the number of animals that can be housed in a given space footprint, and they are thus able to support large and diverse research programs. This review is designed to provide managers, lab animal veterinarians, investigators, and other parties responsible for care and use of these animals with a comprehensive overview of the basic operating and design principles of zebrafish housing systems. This information can be used to help plan the construction of new facilities and/or the upgrade and maintenance of existing operations. PMID:23382349

Quantum heat engine operating between thermal and spin reservoirs

NASA Astrophysics Data System (ADS)

Wright, Jackson S. S. T.; Gould, Tim; Carvalho, André R. R.; Bedkihal, Salil; Vaccaro, Joan A.

2018-05-01

Landauer's erasure principle is a cornerstone of thermodynamics and information theory [R. Landauer, IBM J. Res. Dev. 5, 183 (1961), 10.1147/rd.53.0183]. According to this principle, erasing information incurs a minimum energy cost. Recently, Vaccaro and Barnett [J. A. Vaccaro and S. M. Barnett, Proc. R. Soc. A 467, 1770 (2011), 10.1098/rspa.2010.0577] explored information erasure in the context of multiple conserved quantities and showed that the erasure cost can be solely in terms of spin angular momentum. As Landauer's erasure principle plays a fundamental role in heat engines, their result considerably widens the possible configurations that heat engines can have. Motivated by this, we propose here an optical heat engine that operates under a single thermal reservoir and a spin angular momentum reservoir coupled to a three-level system with two energy degenerate ground states. The proposed heat engine operates without producing waste heat and goes beyond the traditional Carnot engine where the working fluid is subjected to two thermal baths at different temperatures.

Minimization of Vibroacoustic Effects as a Criterion for Operation of Gear Transmissions in Accordance with Sustainable Development Principles

NASA Astrophysics Data System (ADS)

Wieczorek, Andrzej N.; Kruk, Radosław

2016-03-01

In correctly functioning maintenance systems it is most important to prevent possible failures. A reduction of the vibroacoustic effects accompanying the operation of machines and equipment, including transmissions, is among the factors that lower the probability of a failure. The paper presents the results of the research on the impact of operational factors on vibroacoustic conditions of transmissions. The factors covered by the analysis included a change in the mating conditions of gear wheels associated with the wear of tooth surfaces, operation of transmissions in subharmonic conditions of the main resonance and the temperature of the lubricating oil. The study demonstrated that it was possible to reduce the vibroacoustic effects generated by gear transmissions by changing the conditions of their operation. Based on the results obtained, it has been found that the operation of gear transmissions in accordance with the sustainable development principles requires technical services to take active measures consisting in the search for optimal operating conditions in terms of the vibroacoustic conditions.

Extraction and Antibacterial Properties of Thyme Leaf Extracts: Authentic Practice of Green Chemistry

ERIC Educational Resources Information Center

Purcell, Sean C.; Pande, Prithvi; Lin, Yingxin; Rivera, Ernesto J.; Paw U, Latisha; Smallwood, Luisa M.; Kerstiens, Geri A.; Armstrong, Laura B.; Robak, MaryAnn T.; Baranger, Anne M.; Douskey, Michelle C.

2016-01-01

In this undergraduate analytical chemistry experiment, students quantitatively assess the antibacterial activity of essential oils found in thyme leaves ("Thymus vulgaris") in an authentic, research-like environment. This multi-week experiment aims to instill green chemistry principles as intrinsic to chemical problem solving. Students…

Developing a Survey of Transformative Learning Outcomes and Processes Based on Theoretical Principles

ERIC Educational Resources Information Center

Stuckey, Heather L.; Taylor, Edward W.; Cranton, Patricia

2013-01-01

The purpose of this research was to develop an inclusive evaluation of "transformative learning theory" that encompassed varied perspectives of transformative learning. We constructed a validated quantitative survey to assess the potential outcomes and processes of how transformative learning may be experienced by college-educated…

Kinesthetic Activities for the Classroom

ERIC Educational Resources Information Center

Mylott, Elliot; Dunlap, Justin; Lampert, Lester; Widenhorn, Ralf

2014-01-01

Educators have found that kinesthetic involvement in an experiment or demonstration can engage students in a powerful way. With that as our goal, we developed three activities that allow students to connect with and quantitatively explore key physics principles from mechanics with three fun physical challenges. By presenting these activities as…

Research in Education: Evidence-Based Inquiry, 7th Edition. MyEducationLab Series

ERIC Educational Resources Information Center

McMillan, James H.; Schumacher, Sally

2010-01-01

This substantially revised text provides a comprehensive, highly accessible, and student friendly introduction to the principles, concepts, and methods currently used in educational research. This text provides a balanced combination of quantitative and qualitative methods and enables students to master skills in reading, understanding,…

Review of Federal Reference Method for Ozone: Nitric Oxide-Chemiluminescence

EPA Science Inventory

•The proposed new FRM measurement principle for ozone is based on quantitative measurement of the chemiluminescence emission from the gas-phase reaction of ozone in an air sample with nitric oxide (NO).•The chemiluminescence from the NO-O3 reaction (with excess NO) is p...

How Dispositional Learning Analytics Helps Understanding the Worked-Example Principle

ERIC Educational Resources Information Center

Tempelaar, Dirk

2017-01-01

This empirical study aims to demonstrate how Dispositional Learning Analytics can contribute in the investigation of the effectiveness of didactical scenarios in authentic settings, where previous research has mostly been laboratory based. Using a showcase based on learning processes of 1080 students in a blended introductory quantitative course,…

Real-time PCR: Advanced technologies and applications

USDA-ARS?s Scientific Manuscript database

This book brings together contributions from 20 experts in the field of PCR, providing a broad perspective of the applications of quantitative real-time PCR (qPCR). The editors state in the preface that the aim is to provide detailed insight into underlying principles and methods of qPCR to provide ...

Examining the Relationship between Electronic Health Record Interoperability and Quality Management

ERIC Educational Resources Information Center

Purcell, Bernice M.

2013-01-01

A lack of interoperability impairs data quality among health care providers' electronic health record (EHR) systems. The problem is whether the International Organization for Standardization (ISO) 9000 principles relate to the problem of interoperability in implementation of EHR systems. The purpose of the nonexperimental quantitative research…

La Methode Experimentale en Pedagogie (The Experimental Method in Pedagogy)

ERIC Educational Resources Information Center

Rouquette, Michel-Louis

1975-01-01

The pedagogue is caught between the qualitative and quantitative or regularized aspects of his work, a situation not automatically conducive to scientific study. The article refreshes the instructor on the elementary principles of experimentation: observation, systematization, elaboration of hypothesis, and startegies of comparison. (Text is in…

Quantum Theory, the Uncertainty Principle, and the Alchemy of Standardized Testing.

ERIC Educational Resources Information Center

Wassermann, Selma

2001-01-01

Argues that reliance on the outcome of quantitative standardized tests to assess student performance is misplaced quest for certainty in an uncertain world. Reviews and lauds Canadian teacher-devised qualitative diagnostic tool, "Profiles of Student Behaviors," composed of 20 behavioral patterns in student knowledge, attitude, and skill.…

Bioinformatics for Undergraduates: Steps toward a Quantitative Bioscience Curriculum

ERIC Educational Resources Information Center

Chapman, Barbara S.; Christmann, James L.; Thatcher, Eileen F.

2006-01-01

We describe an innovative bioinformatics course developed under grants from the National Science Foundation and the California State University Program in Research and Education in Biotechnology for undergraduate biology students. The project has been part of a continuing effort to offer students classroom experiences focused on principles and…

Main principles and technique of electronystagmography (a brief survey of the literature)

NASA Technical Reports Server (NTRS)

Tanchev, K. S.

1980-01-01

Electronystagmography (ENG) is one of the modern methods for objective recording of nystagmus, its quantitative and qualitative assessment. It is used more and more often in clinical practice. A brief review of the history of recording of nystagmus and a survey of the relevant literature is presented.

Some heat engine cycles in which liquids can work.

PubMed

Allen, P C; Paulson, D N; Wheatley, J C

1981-01-01

Liquids can work in heat engine cycles that employ regeneration. Four such cycles are discussed: Stirling, Malone, Stirling-Malone, and Brayton. Both regeneration and the role of the second thermodynamic medium are treated, and the principles are verified by quantitative measurements with propylene in a Stirling-Malone cycle.

Some heat engine cycles in which liquids can work

PubMed Central

Allen, P. C.; Paulson, D. N.; Wheatley, J. C.

1981-01-01

Liquids can work in heat engine cycles that employ regeneration. Four such cycles are discussed: Stirling, Malone, Stirling-Malone, and Brayton. Both regeneration and the role of the second thermodynamic medium are treated, and the principles are verified by quantitative measurements with propylene in a Stirling-Malone cycle. PMID:16592952

Research Methods Tutorial

NASA Technical Reports Server (NTRS)

Aguilera, Frank J.

2015-01-01

A guiding principle for conducting research in technology, science, and engineering, leading to innovation is based on our use of research methodology (both qualitative and quantitative). A brief review of research methodology will be presented with an overview of NASA process in developing aeronautics technologies and other things to consider in research including what is innovation.

Job-Embedded Professional Development: Its Impact on Teacher Self-Efficacy and Student Performance

ERIC Educational Resources Information Center

Althauser, Krista

2015-01-01

A quantitative approach was used to investigate the impact of a district-wide, job-embedded mathematics professional development program on elementary teachers' general and personal efficacy. This investigation was based on the principles of mathematics professional development, efficacy theory, and student achievement. It was designed to…

A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening

PubMed Central

Soraya, Gita V.; Nguyen, Thanh C.; Abeyrathne, Chathurika D.; Huynh, Duc H.; Chan, Jianxiong; Nguyen, Phuong D.; Nasr, Babak; Chana, Gursharan; Kwan, Patrick; Skafidas, Efstratios

2017-01-01

The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 µg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems. PMID:28475117

Human-Centered Aviation Automation: Principles and Guidelines

NASA Technical Reports Server (NTRS)

Billings, Charles E.

1996-01-01

This document presents principles and guidelines for human-centered automation in aircraft and in the aviation system. Drawing upon operational experience with highly automated aircraft, it describes classes of problems that have occurred in these vehicles, the effects of advanced automation on the human operators of the aviation system, and ways in which these problems may be avoided in the design of future aircraft and air traffic management automation. Many incidents and a few serious accidents suggest that these problems are related to automation complexity, autonomy, coupling, and opacity, or inadequate feedback to operators. An automation philosophy that emphasizes improved communication, coordination and cooperation between the human and machine elements of this complex, distributed system is required to improve the safety and efficiency of aviation operations in the future.

A Blueprint for Success. Operation Rescue.

ERIC Educational Resources Information Center

National Foundation for the Improvement of Education, Washington, DC.

A set of principles that focus on issues concerning implementation of a successful dropout prevention program is presented by a consortium of national educational organizations. The key elements of this "blueprint" consider local adaptations and effective results among various programs. The booklet discusses seven principles for dropout…

40 CFR 60.613 - Monitoring of emissions and operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., photoionization, or thermal conductivity, each equipped with a continuous recorder. (2) Where a condenser is the... detection principle such as infra-red, photoionization, or thermal conductivity, each equipped with a... based on a detection principle such as infra-red, photoionization, or thermal conductivity, each...

48 CFR 970.3102-05-6 - Compensation for personal services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contract Cost Principles and... of the contract. This personnel appendix shall be negotiated using the principles and policies of 48... related expenses allowable under the contract and documents personnel policies, practices and plans which...

Operational Risk Defined Through a Complex Operating Environment

DTIC Science & Technology

2015-02-26

including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed , and completing and reviewing...This argument defines operational risk as any environmental, institutional, or social impediment to the principles of joint operations that disrupt...Restraint, Perseverance, and Legitimacy. This argument defines operational risk as any environmental, institutional, or social impediment to the

GUIDING PRINCIPLES FOR GOOD PRACTICES IN HOSPITAL-BASED HEALTH TECHNOLOGY ASSESSMENT UNITS.

PubMed

Sampietro-Colom, Laura; Lach, Krzysztof; Pasternack, Iris; Wasserfallen, Jean-Blaise; Cicchetti, Americo; Marchetti, Marco; Kidholm, Kristian; Arentz-Hansen, Helene; Rosenmöller, Magdalene; Wild, Claudia; Kahveci, Rabia; Ulst, Margus

2015-01-01

Health technology assessment (HTA) carried out for policy decision making has well-established principles unlike hospital-based HTA (HB-HTA), which differs from the former in the context characteristics and ways of operation. This study proposes principles for good practices in HB-HTA units. A framework for good practice criteria was built inspired by the EFQM excellence business model and information from six literature reviews, 107 face-to-face interviews, forty case studies, large-scale survey, focus group, Delphi survey, as well as local and international validation. In total, 385 people from twenty countries have participated in defining the principles for good practices in HB-HTA units. Fifteen guiding principles for good practices in HB-HTA units are grouped in four dimensions. Dimension 1 deals with principles of the assessment process aimed at providing contextualized information for hospital decision makers. Dimension 2 describes leadership, strategy and partnerships of HB-HTA units which govern and facilitate the assessment process. Dimension 3 focuses on adequate resources that ensure the operation of HB-HTA units. Dimension 4 deals with measuring the short- and long-term impact of the overall performance of HB-HTA units. Finally, nine core guiding principles were selected as essential requirements for HB-HTA units based on the expertise of the HB-HTA units participating in the project. Guiding principles for good practices set up a benchmark for HB-HTA because they represent the ideal performance of HB-HTA units; nevertheless, when performing HTA at hospital level, context also matters; therefore, they should be adapted to ensure their applicability in the local context.

A Tale of Two Community Networks Program Centers: Operationalizing and Assessing CBPR Principles and Evaluating Partnership Outcomes

PubMed Central

Arroyo-Johnson, Cassandra; Allen, Michele L.; Colditz, Graham A.; Hurtado, G. Ali; Davey, Cynthia S.; Sanders Thompson, Vetta L.; Drake, Bettina F.; Svetaz, Maria Veronica; Rosas-Lee, Maira; Goodman, Melody S.

2016-01-01

Background Community Networks Program (CNP) centers are required to use a community-based participatory research (CBPR) approach within their specific priority communities. Not all communities are the same and unique contextual factors and collaborators’ priorities shape each CBPR partnership. There are also established CBPR and community engagement (CE) principles shown to lead to quality CBPR in any community. However, operationalizing and assessing CBPR principles and partnership outcomes to understand the conditions and processes in CBPR that lead to achieving program and project level goals is relatively new in the science of CBPR. Objectives We sought to describe the development of surveys on adherence to and implementation of CBPR/CE principles at two CNP centers and examine commonalities and differences in program- versus project-level CBPR evaluation. Methods A case study about the development and application of CBPR/CE principles for the Missouri CNP, Program for the Elimination of Cancer Disparities, and Minnesota CNP, Padres Informados/Jovenes Preparados, surveys was conducted to compare project versus program operationalization of principles. Survey participant demographics were provided by CNP. Specific domains found in CBPR/CE principles were identified and organized under an existing framework to establish a common ground. Operational definitions and the number of survey items were provided for each domain by CNP. Conclusion There are distinct differences in operational definitions of CBPR/CE principles at the program and project levels of evaluation. However, commonalities support further research to develop standards for CBPR evaluation across partnerships and at the program and project levels. PMID:26213405

Representing Operational Modes for Situation Awareness

NASA Astrophysics Data System (ADS)

Kirchhübel, Denis; Lind, Morten; Ravn, Ole

2017-01-01

Operating complex plants is an increasingly demanding task for human operators. Diagnosis of and reaction to on-line events requires the interpretation of real time data. Vast amounts of sensor data as well as operational knowledge about the state and design of the plant are necessary to deduct reasonable reactions to abnormal situations. Intelligent computational support tools can make the operator’s task easier, but they require knowledge about the overall system in form of some model. While tools used for fault-tolerant control design based on physical principles and relations are valuable tools for designing robust systems, the models become too complex when considering the interactions on a plant-wide level. The alarm systems meant to support human operators in the diagnosis of the plant-wide situation on the other hand fail regularly in situations where these interactions of systems lead to many related alarms overloading the operator with alarm floods. Functional modelling can provide a middle way to reduce the complexity of plant-wide models by abstracting from physical details to more general functions and behaviours. Based on functional models the propagation of failures through the interconnected systems can be inferred and alarm floods can potentially be reduced to their root-cause. However, the desired behaviour of a complex system changes due to operating procedures that require more than one physical and functional configuration. In this paper a consistent representation of possible configurations is deduced from the analysis of an exemplary start-up procedure by functional models. The proposed interpretation of the modelling concepts simplifies the functional modelling of distinct modes. The analysis further reveals relevant links between the quantitative sensor data and the qualitative perspective of the diagnostics tool based on functional models. This will form the basis for the ongoing development of a novel real-time diagnostics system based on the on-line adaptation of the underlying MFM model.

Integrated standardization concept for Angelica botanicals using quantitative NMR

PubMed Central

Gödecke, Tanja; Yao, Ping; Napolitano, José G.; Nikolić, Dejan; Dietz, Birgit M.; Bolton, Judy L.; van Breemen, Richard B.; Farnsworth, Norman R.; Chen, Shao-Nong; Lankin, David C.; Pauli, Guido F.

2011-01-01

Despite numerous in vitro/vivo and phytochemical studies, the active constituents of Angelica sinensis (AS) have not been conclusively identified for the standardization to bioactive markers. Phytochemical analyses of AS extracts and fractions that demonstrate activity in a panel of in vitro bioassays, have repeatedly pointed to ligustilide as being (associated with) the active principle(s). Due to the chemical instability of ligustilide and related issues in GC/LC analyses, new methods capable of quantifying ligustilide in mixtures that do not rely on an identical reference standard are in high demand. This study demonstrates how NMR can satisfy the requirement for simultaneous, multi-target quantification and qualitative identification. First, the AS activity was concentrated into a single fraction by RP-solid-phase extraction, as confirmed by an (anti-)estrogenicity and cytotoxicity assay. Next, a quantitative 1H NMR (qHNMR) method was established and validated using standard compounds and comparing processing methods. Subsequent 1D/2D NMR and qHNMR analysis led to the identification and quantification of ligustilide and other minor components in the active fraction, and to the development of quality criteria for authentic AS preparations. The absolute and relative quantities of ligustilide, six minor alkyl phthalides, and groups of phenylpropanoids, polyynes, and poly-unsaturated fatty acids were measured by a combination of qHNMR and 2D COSY. The qNMR approach enables multi-target quality control of the bioactive fraction, and enables the integrated biological and chemical standardization of AS botanicals. This methodology can potentially be transferred to other botanicals with active principles that act synergistically, or that contain closely related and/or constituents, which have not been conclusively identified as the active principles. PMID:21907766

Cosmological constant implementing Mach principle in general relativity

NASA Astrophysics Data System (ADS)

Namavarian, Nadereh; Farhoudi, Mehrdad

2016-10-01

We consider the fact that noticing on the operational meaning of the physical concepts played an impetus role in the appearance of general relativity (GR). Thus, we have paid more attention to the operational definition of the gravitational coupling constant in this theory as a dimensional constant which is gained through an experiment. However, as all available experiments just provide the value of this constant locally, this coupling constant can operationally be meaningful only in a local area. Regarding this point, to obtain an extension of GR for the large scale, we replace it by a conformal invariant model and then, reduce this model to a theory for the cosmological scale via breaking down the conformal symmetry through singling out a specific conformal frame which is characterized by the large scale characteristics of the universe. Finally, we come to the same field equations that historically were proposed by Einstein for the cosmological scale (GR plus the cosmological constant) as the result of his endeavor for making GR consistent with the Mach principle. However, we declare that the obtained field equations in this alternative approach do not carry the problem of the field equations proposed by Einstein for being consistent with Mach's principle (i.e., the existence of de Sitter solution), and can also be considered compatible with this principle in the Sciama view.

43 CFR 418.33 - Purpose of the implementation strategy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... implement through their discretionary actions, operating strategies which achieve the principles of this... project operations, economics, and environmental effects. (c) The efficiency target will be used as a...

To what extent can PBL principles be applied in blended learning: Lessons learned from health master programs.

PubMed

de Jong, N; Krumeich, J S M; Verstegen, D M L

2017-02-01

Maastricht University has been actively exploring blended learning approaches to PBL in Health Master Programs. Key principles of PBL are, learning should be constructive, self-directed, collaborative, and contextual. The purpose is to explore whether these principles are applicable in blended learning. The programs, Master of Health Services Innovation (case 1), Master Programme in Global Health (case 2), and the Master of Health Professions Education (case 3), used a Virtual Learning Environment for exchanging material and were independently analyzed. Quantitative data were collected for cases 1 and 2. Simple descriptive analyses such as frequencies were performed. Qualitative data for cases 1 and 3 were collected via (focus group) interviews. All PBL principles could be recognized in case 1. Case 2 seemed to be more project-based. In case 3, collaboration between students was not possible because of a difference in time-zones. Important educational aspects: agreement on rules for (online) sessions; visual contact (student-student and student-teacher), and frequent feedback. PBL in a blended learning format is perceived to be an effective strategy. The four principles of PBL can be unified in PBL with a blended learning format, although the extent to which each principle can be implemented can differ.

Strategic, Analytic and Operational Domains of Information Management.

ERIC Educational Resources Information Center

Diener, Richard AV

1992-01-01

Discussion of information management focuses on three main areas of activities and their interrelationship: (1) strategic, including establishing frameworks and principles of operations; (2) analytic, or research elements, including user needs assessment, data gathering, and data analysis; and (3) operational activities, including reference…

Principles of Sociology in Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Andrews, James G.; Larsen, Jordan A.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, often with different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated with all relevant information informing system decisions. Robert K. Merton studied the sociological principles of the sciences and the sociological principles he developed apply to systems engineering. Concepts such as specification of ignorance, common terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that should be employed by the systems engineer. In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, insider-outsider behavior, unintended consequences, and the self-fulfilling prophecy. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information. This also helps identify key sociological barriers to information flow through the organization. This paper will discuss this theoretical basis for the application of sociological principles to systems engineering.

An Evaporative Cooling Model for Teaching Applied Psychrometrics

ERIC Educational Resources Information Center

Johnson, Donald M.

2004-01-01

Evaporative cooling systems are commonly used in controlled environment plant and animal production. These cooling systems operate based on well defined psychrometric principles. However, students often experience considerable difficulty in learning these principles when they are taught in an abstract, verbal manner. This article describes an…

Some algebraic clues towards a syntactic view on the Principles of Non-Contradiction and Excluded-Middle

NASA Astrophysics Data System (ADS)

Trillas, E.; García-Honrado, I.; Termini, S.

2014-02-01

This short paper just considers the possibility of a new view for posing and proving Aristotle's Principles of Non-Contradiction and Excluded-Middle. It is done by means of their refutability, or deducibility, respectively, under Tarski's Consequence Operators.

Desert Operations Tactics, Techniques, and Procedures. Southwest Asia Focus

DTIC Science & Technology

1990-11-01

6-5 CONTAM IN ATION TRAN SFER ...................................................................... 6-7 PRINCIPLES OF CONTAMINATION AVOIDANCE...6-14 Decontam ination Principles ....................................................................... 6-14 Aircraft Spraydown...moisture or food, lice, mites, and flies can be extremely unpleasant and carry diseases such as scrub typhus and dysentery. The stings of many

Biological monitoring of Upper Three Runs Creek, Savannah River Plant, Aiken County, South Carolina

DOE Office of Scientific and Technical Information (OSTI.GOV)

Specht, W.L.

1991-10-01

In anticipation of the fall 1988 start up of effluent discharges into Upper Three Creek by the F/H Area Effluent Treatment Facility of the Savannah River Site, Aiken, SC, a two and one half year biological study was initiated in June 1987. Upper Three Runs Creek is an intensively studied fourth order stream known for its high species richness. Designed to assess the potential impact of F H area effluent on the creek, the study includes qualitative and quantitative macroinvertebrate stream surveys at five sites, chronic toxicity testing of the effluent, water chemistry and bioaccumulation analysis. This final report presentsmore » the results of both pre-operational and post-operational qualitative and quantitative (artificial substrate) macroinvertebrate studies. Six quantitative and three qualitative studies were conducted prior to the initial release of the F/H ETF effluent and five quantitative and two qualitative studies were conducted post-operationally.« less

The principles and conduct of anaesthesia for emergency surgery.

PubMed

Gray, L D; Morris, C

2013-01-01

In this second article we examine the principles underlying delivery of the components of anaesthesia. Topics considered include anaesthetic technique, management of the airway and lung ventilation, induction and maintenance of anaesthesia, patient monitoring including the place of cardiac output devices. We summarise recent research on the management of shock and sepsis syndromes including goal directed therapy and examine some controversies around intravenous fluid therapy. Finally, we discuss intra-operative awareness and challenges during emergence including peri-operative cognitive dysfunction. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.

A Model of Risk Analysis in Analytical Methodology for Biopharmaceutical Quality Control.

PubMed

Andrade, Cleyton Lage; Herrera, Miguel Angel De La O; Lemes, Elezer Monte Blanco

2018-01-01

One key quality control parameter for biopharmaceutical products is the analysis of residual cellular DNA. To determine small amounts of DNA (around 100 pg) that may be in a biologically derived drug substance, an analytical method should be sensitive, robust, reliable, and accurate. In principle, three techniques have the ability to measure residual cellular DNA: radioactive dot-blot, a type of hybridization; threshold analysis; and quantitative polymerase chain reaction. Quality risk management is a systematic process for evaluating, controlling, and reporting of risks that may affects method capabilities and supports a scientific and practical approach to decision making. This paper evaluates, by quality risk management, an alternative approach to assessing the performance risks associated with quality control methods used with biopharmaceuticals, using the tool hazard analysis and critical control points. This tool provides the possibility to find the steps in an analytical procedure with higher impact on method performance. By applying these principles to DNA analysis methods, we conclude that the radioactive dot-blot assay has the largest number of critical control points, followed by quantitative polymerase chain reaction, and threshold analysis. From the analysis of hazards (i.e., points of method failure) and the associated method procedure critical control points, we conclude that the analytical methodology with the lowest risk for performance failure for residual cellular DNA testing is quantitative polymerase chain reaction. LAY ABSTRACT: In order to mitigate the risk of adverse events by residual cellular DNA that is not completely cleared from downstream production processes, regulatory agencies have required the industry to guarantee a very low level of DNA in biologically derived pharmaceutical products. The technique historically used was radioactive blot hybridization. However, the technique is a challenging method to implement in a quality control laboratory: It is laborious, time consuming, semi-quantitative, and requires a radioisotope. Along with dot-blot hybridization, two alternatives techniques were evaluated: threshold analysis and quantitative polymerase chain reaction. Quality risk management tools were applied to compare the techniques, taking into account the uncertainties, the possibility of circumstances or future events, and their effects upon method performance. By illustrating the application of these tools with DNA methods, we provide an example of how they can be used to support a scientific and practical approach to decision making and can assess and manage method performance risk using such tools. This paper discusses, considering the principles of quality risk management, an additional approach to the development and selection of analytical quality control methods using the risk analysis tool hazard analysis and critical control points. This tool provides the possibility to find the method procedural steps with higher impact on method reliability (called critical control points). Our model concluded that the radioactive dot-blot assay has the larger number of critical control points, followed by quantitative polymerase chain reaction and threshold analysis. Quantitative polymerase chain reaction is shown to be the better alternative analytical methodology in residual cellular DNA analysis. © PDA, Inc. 2018.

Estimation of sample size and testing power (part 5).

PubMed

Hu, Liang-ping; Bao, Xiao-lei; Guan, Xue; Zhou, Shi-guo

2012-02-01

Estimation of sample size and testing power is an important component of research design. This article introduced methods for sample size and testing power estimation of difference test for quantitative and qualitative data with the single-group design, the paired design or the crossover design. To be specific, this article introduced formulas for sample size and testing power estimation of difference test for quantitative and qualitative data with the above three designs, the realization based on the formulas and the POWER procedure of SAS software and elaborated it with examples, which will benefit researchers for implementing the repetition principle.

Methods and apparatus for managing corrosion in buildings

DOEpatents

Chey, S Jay; Hamann, Hendrik F; Klein, Levente Ioan; Schappert, Michael Alan; Stepanchuk, Andriy

2015-02-03

Principles of the invention provide methods and apparatus for providing corrosion management in buildings. In one aspect, an exemplary method includes the step of receiving first data relating corrosion rate to a plurality of environmental conditions. This first data is subsequently utilized to determine a quantitative relationship between corrosion rate and the plurality of environmental conditions. In another step, second data indicative of one or more environmental conditions within a building is received. A corrosion rate in the building is then determined at least in part by applying the determined quantitative relationship to this second data.

Silicon solar cell process development, fabrication and analysis

NASA Technical Reports Server (NTRS)

Leung, D. C.; Iles, P. A.

1983-01-01

Measurements of minority carrier diffusion lengths were made on the small mesa diodes from HEM Si and SILSO Si. The results were consistent with previous Voc and Isc measurements. Only the medium grain SILSO had a distinct advantage for the non grain boundary diodes. Substantial variations were observed for the HEM ingot 4141C. Also a quantitatively scaled light spot scan was being developed for localized diffusion length measurements in polycrystalline silicon solar cells. A change to a more monochromatic input for the light spot scan results in greater sensitivity and in principle, quantitative measurement of local material qualities is now possible.

Boltzmann, Darwin and Directionality theory

NASA Astrophysics Data System (ADS)

Demetrius, Lloyd A.

2013-09-01

Boltzmann’s statistical thermodynamics is a mathematical theory which relates the macroscopic properties of aggregates of interacting molecules with the laws of their interaction. The theory is based on the concept thermodynamic entropy, a statistical measure of the extent to which energy is spread throughout macroscopic matter. Macroscopic evolution of material aggregates is quantitatively explained in terms of the principle: Thermodynamic entropy increases as the composition of the aggregate changes under molecular collision. Darwin’s theory of evolution is a qualitative theory of the origin of species and the adaptation of populations to their environment. A central concept in the theory is fitness, a qualitative measure of the capacity of an organism to contribute to the ancestry of future generations. Macroscopic evolution of populations of living organisms can be qualitatively explained in terms of a neo-Darwinian principle: Fitness increases as the composition of the population changes under variation and natural selection. Directionality theory is a quantitative model of the Darwinian argument of evolution by variation and selection. This mathematical theory is based on the concept evolutionary entropy, a statistical measure which describes the rate at which an organism appropriates energy from the environment and reinvests this energy into survivorship and reproduction. According to directionality theory, microevolutionary dynamics, that is evolution by mutation and natural selection, can be quantitatively explained in terms of a directionality principle: Evolutionary entropy increases when the resources are diverse and of constant abundance; but decreases when the resource is singular and of variable abundance. This report reviews the analytical and empirical support for directionality theory, and invokes the microevolutionary dynamics of variation and selection to delineate the principles which govern macroevolutionary dynamics of speciation and extinction. We also elucidate the relation between thermodynamic entropy, which pertains to the extent of energy spreading and sharing within inanimate matter, and evolutionary entropy, which refers to the rate of energy appropriation from the environment and allocation within living systems. We show that the entropic principle of thermodynamics is the limit as R→0, M→∞, (where R denote the resource production rate, and M denote population size) of the entropic principle of evolution. We exploit this relation between the thermodynamic and evolutionary tenets to propose a physico-chemical model of the transition from inanimate matter which is under thermodynamic selection, to living systems which are subject to evolutionary selection. Life history variation and the evolution of senescence The evolutionary dynamics of speciation and extinction Evolutionary trends in body size. The origin of sporadic forms of cancer and neurological diseases, and the evolution of cooperation are important recent applications of directionality theory. These applications, which draw from the medical sciences and sociobiology, appeal to methods which lie outside the formalism described in this report. A companion review, Demetrius and Gundlach (submitted for publication), gives an account of these applications.An important aspect of this report pertains to the connection between statistical mechanics and evolutionary theory and its implications towards understanding the processes which underlie the emergence of living systems from inanimate matter-a problem which has recently attracted considerable attention, Morowitz (1992), Eigen (1992), Dyson (2000), Pross (2012).The connection between the two disciplines can be addressed by appealing to certain extremal principles which are considered the mainstay of the respective theories.The extremal principle in statistical mechanics can be stated as follows:

Two additional principles for determining which species to monitor.

PubMed

Wilson, Howard B; Rhodes, Jonathan R; Possingham, Hugh P

2015-11-01

Monitoring to detect population declines is widespread, but also costly. There is, consequently, a need to optimize monitoring to maximize cost-effectiveness. Here we develop a quantitative decision analysis framework for how to optimally allocate resources for monitoring among species. By keeping the framework simple, we analytically establish two new principles about which species are optimal to monitor for detecting declines: (1) those that lie on the boundary between species being allocated resources for conservation action and species that are not and (2) those with the greatest uncertainty in whether they are declining. These two principles are in addition to other factors that are also important in monitoring decisions, such as complementarity. We demonstrate the efficacy of these principles when other factors are not present, and show how the two principles can be combined. This analysis demonstrates that the most cost-effective species to monitor are ones where the information gained from monitoring is most likely to change the allocation of funds for action, not necessarily the most vulnerable or endangered. We suggest these results are general and apply to all ecological monitoring, not just of biological species: monitoring and information are only valuable when they are likely to change how people act.

Validation of Bateman's principles: a genetic study of sexual selection and mating patterns in the rough-skinned newt.

PubMed Central

Jones, Adam G; Arguello, J Roman; Arnold, Stevan J

2002-01-01

Few studies have influenced thought on the nature of sexual selection to the extent of the classic paper of A. J. Bateman on mating patterns in Drosophila. However, interpretation of his study remains controversial, and a lack of modern empirical evidence prevents a consensus with respect to the perceived utility of Bateman's principles in the study of sexual selection. Here, we use a genetic study of natural mating patterns in the rough-skinned newt, Taricha granulosa, to investigate the concordance between Bateman's principles and the intensity of sexual selection. We found that males experienced strong sexual selection on tail height and body size, while sexual selection was undetectable in females. This direct quantification of sexual selection agreed perfectly with inferences that are based on Bateman's principles. Specifically, males (in comparison with females) exhibited greater standardized variances in reproductive and mating success, as well as a stronger relationship between mating success and reproductive success. Overall, our results illustrate that Bateman's principles provide the only quantitative measures of the mating system with explicit connections to formal selection theory and should be the central focus of studies of mating patterns in natural populations. PMID:12573067

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging... procedures; (xii) Pre-startup inspections; and (xiii) Recordkeeping requirements. (2) An examination designed...

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... following subjects: (i) Environmental concerns, including pathogen destruction and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging, and shutdown procedures; (iv...

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... following subjects: (i) Environmental concerns, including pathogen destruction and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging, and shutdown procedures; (iv...

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging... procedures; (xii) Pre-startup inspections; and (xiii) Recordkeeping requirements. (2) An examination designed...

50 CFR 600.1003 - Content of a request for a financed program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requester's endorsement in principle of the reduction amendment specifications in the business plan. Endorsement in principle is non-binding. (h) Request that NMFS conduct, at the appropriate time, a referendum... operating economics of typical harvesters in the reduction fishery, with particular emphasis on the extent...

Managing and Correcting Defiant Behavior through Music

ERIC Educational Resources Information Center

Lohmeyer, Aaron Z.

2017-01-01

The purpose of this article is to share principles and strategies that may be used to teach appropriate behaviors to students that that may struggle with an emotional behavior disorder. Operating from the principle that music is naturally rewarding, classroom procedures and lessons that address preparation, imagination, effortful control, pacing,…

42 CFR 51c.303 - Project elements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... accepted accounting principles, be considered income and expense items; (2) Provides for a capital... principles, be considered capital items; (3) Provides for plan review and updating at least annually; and (4... grant funds for the operation of a prepaid health care plan also must provide: (1) A marketing and...

26 CFR 1.482-3 - Methods to determine taxable income in connection with a transfer of tangible property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... range. (4) Examples. The principles of this paragraph (b) are illustrated by the following examples..., marketing, advertising programs and services, (including promotional programs, rebates, and co-op... sold and operating expenses. (4) Examples. The following examples illustrate the principles of this...

Self-Evaluation Instrument: Awards Program for Indoor Air Quality Management in Schools.

ERIC Educational Resources Information Center

Maryland State Dept. of Education, Baltimore.

This self-evaluation instrument is used to nominate and evaluate schools for the Indoor Air Quality Management in Schools award. The evaluation contains three categories: Communications/Training; Design; and Operations/Maintenance. Each principle is detailed along with the required criteria used to meet that principle. Communications/Training…

Planning for Impact: A Guide to Planning Effective Family Program.

ERIC Educational Resources Information Center

Hardy, James M.

A document intended to provide program planning guidelines for Young Men's Christian Associations (YMCAs) desirous of working with families, recommends adherence to eight principles and following of five steps. The principles involve planning before action, fact finding and analysis, clear delineation of operational objectives, planning at all…

Challenges in Teaching the Mechanics of Breathing to Medical and Graduate Students

ERIC Educational Resources Information Center

West, John B.

2008-01-01

The mechanics of breathing has always been a difficult topic for some medical and graduate students. The subject is very quantitative and contains a number of concepts that some students have trouble with, including physical principles such as pressure, flow, volume, resistance, elasticity, and compliance. Apparently, present-day students find the…

A disciplined approach to capital: today's healthcare imperative.

PubMed

Dupuis, Patrick J; Kaufman, Kenneth

2007-07-01

BJC HealthCare's experience exemplifies several basic principles of a finance-based approach to capital. Organizations that adopt this approach look to improve processes first, remove costs second, and spend capital last. Multiyear planning is required to quantitatively identify the profitability and liquidity requirements of strategic initiatives and address essential funding and financing issues.

From Universal Laws of Cognition to Specific Cognitive Models

ERIC Educational Resources Information Center

Chater, Nick; Brown, Gordon D. A.

2008-01-01

The remarkable successes of the physical sciences have been built on highly general quantitative laws, which serve as the basis for understanding an enormous variety of specific physical systems. How far is it possible to construct universal principles in the cognitive sciences, in terms of which specific aspects of perception, memory, or decision…

Effects of Teacher Certification on the Educational Achievement of African American Students

ERIC Educational Resources Information Center

Wheeler-Davenport, Veronica

2014-01-01

The purpose of this nonexperimental quantitative study was to explore the effects of teachers' certification on the achievement of African American students. The impetus for this exploration resided in the reading achievement disparities between African American and Caucasian students in the study district. Guided by the principles of total…

Qualititive and Quantitative Allocations of Program Funds in a Non-Profit Institution.

ERIC Educational Resources Information Center

Brown, Edward K.

Through a generalized application of the principles of programing-planning-budgeting (PPB), a process was devised for describing the methods of resource allocation in a nonprofit institution. By categorizing pupil service inputs according to basic skills, instruction, and supportive services it became possible to identify meaningful service input…

Effects of Instruction-Supported Learning with Worked Examples in Quantitative Method Training

ERIC Educational Resources Information Center

Wagner, Kai; Klein, Martin; Klopp, Eric; Puhl, Thomas; Stark, Robin

2013-01-01

An experimental field study at a German university was conducted in order to test the effectiveness of an integrated learning environment to improve the acquisition of knowledge about empirical research methods. The integrated learning environment was based on the combination of instruction-oriented and problem-oriented design principles and…

The Dynamic Theory, A New View of Space, Time, and Matter

DTIC Science & Technology

1978-03-01

UQ = 0, system the principle of increasing entropy requires that (dqo)2 > 0 so that f (do)2 > 0. Introducing the quantitization conditions results in...added significance in considering the differential change in entropy or dq° =f do. Thus the only mathematically consistent difinition for is 1 lanf ax

Women and Minorities in Economics Textbooks: Are They Being Adequately Represented?

ERIC Educational Resources Information Center

Robson, Denise

2001-01-01

Examines 12 recent editions of principles of economics textbooks to determine the quantity of race- and gender-related material. Finds, in general, that there has been an increase in the quantitative coverage of race- and gender-related material as measured by the number of pages, names, and tables in the textbooks. (RLH)

A Dynamic Analysis of Social Capital-Building of International and UK Students

ERIC Educational Resources Information Center

Rienties, Bart; Johan, Novie; Jindal-Snape, Divya

2015-01-01

Although many international students experience transitional issues, most research assumes these issues will disappear over time. Using principles of social capital theory, this study addressed whether after three years of study students were able to build multi-national and host social capital links. In this quantitative study of 81 students from…

Integration of different data gap filling techniques to facilitate assessment of polychlorinated biphenyls: A proof of principle case study (ASCCT meeting)

EPA Science Inventory

Data gap filling techniques are commonly used to predict hazard in the absence of empirical data. The most established techniques are read-across, trend analysis and quantitative structure-activity relationships (QSARs). Toxic equivalency factors (TEFs) are less frequently used d...

Using the Principles of "BIO2010" to Develop an Introductory, Interdisciplinary Course for Biology Students

ERIC Educational Resources Information Center

Matthews, Kelly E.; Adams, Peter; Goos, Merrilyn

2010-01-01

Modern biological sciences require practitioners to have increasing levels of knowledge, competence, and skills in mathematics and programming. A recent review of the science curriculum at the University of Queensland, a large, research-intensive institution in Australia, resulted in the development of a more quantitatively rigorous undergraduate…

Quantum Interference Effects in Resonant Raman Spectroscopy of Single- and Triple-Layer MoTe2 from First-Principles

NASA Astrophysics Data System (ADS)

Miranda, Henrique P. C.; Reichardt, Sven; Froehlicher, Guillaume; Molina-Sánchez, Alejandro; Berciaud, Stéphane; Wirtz, Ludger

2017-04-01

We present a combined experimental and theoretical study of resonant Raman spectroscopy in single- and triple-layer MoTe$_2$. Raman intensities are computed entirely from first principles by calculating finite differences of the dielectric susceptibility. In our analysis, we investigate the role of quantum interference effects and the electron-phonon coupling. With this method, we explain the experimentally observed intensity inversion of the $A^\\prime_1$ vibrational modes in triple-layer MoTe2 with increasing laser photon energy. Finally, we show that a quantitative comparison with experimental data requires the proper inclusion of excitonic effects.

Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells

PubMed Central

Rodriguez, Jose A.; Xu, Rui; Chen, Chien-Chun; Huang, Zhifeng; Jiang, Huaidong; Chen, Allan L.; Raines, Kevin S.; Pryor Jr, Alan; Nam, Daewoong; Wiegart, Lutz; Song, Changyong; Madsen, Anders; Chushkin, Yuriy; Zontone, Federico; Bradley, Peter J.; Miao, Jianwei

2015-01-01

A structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 keV X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and the three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. It is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres. PMID:26306199

Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells

DOE PAGES

Rodriguez, Jose A.; Xu, Rui; Chen, Chien -Chun; ...

2015-09-01

Here, a structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 Kev X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and themore » three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. Finally, it is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres.« less

Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells.

PubMed

Rodriguez, Jose A; Xu, Rui; Chen, Chien-Chun; Huang, Zhifeng; Jiang, Huaidong; Chen, Allan L; Raines, Kevin S; Pryor, Alan; Nam, Daewoong; Wiegart, Lutz; Song, Changyong; Madsen, Anders; Chushkin, Yuriy; Zontone, Federico; Bradley, Peter J; Miao, Jianwei

2015-09-01

A structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 keV X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and the three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. It is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres.

Principles of Precision Spectrophotometry: An Advanced Undergraduate Experiment

ERIC Educational Resources Information Center

Billmeyer, Fred W., Jr.

1974-01-01

Describes an experiment designed to familiarize students with the operation of a precision spectrophotometer, the effects of changes in operating variables, and the characteristics of such components as sources and detectors. (SLH)

Quantitation of sweet steviol glycosides by means of a HILIC-MS/MS-SIDA approach.

PubMed

Well, Caroline; Frank, Oliver; Hofmann, Thomas

2013-11-27

Meeting the rising consumer demand for natural food ingredients, steviol glycosides, the sweet principle of Stevia rebaudiana Bertoni (Bertoni), have recently been approved as food additives in the European Union. As regulatory constraints require sensitive methods to analyze the sweet-tasting steviol glycosides in foods and beverages, a HILIC-MS/MS method was developed enabling the accurate and reliable quantitation of the major steviol glycosides stevioside, rebaudiosides A-F, steviolbioside, rubusoside, and dulcoside A by using the corresponding deuterated 16,17-dihydrosteviol glycosides as suitable internal standards. This quantitation not only enables the analysis of the individual steviol glycosides in foods and beverages but also can support the optimization of breeding and postharvest downstream processing of Stevia plants to produce preferentially sweet and least bitter tasting Stevia extracts.

Quantitative analysis of domain texture in polycrystalline barium titanate by polarized Raman microprobe spectroscopy

NASA Astrophysics Data System (ADS)

Sakashita, Tatsuo; Chazono, Hirokazu; Pezzotti, Giuseppe

2007-12-01

A quantitative determination of domain distribution in polycrystalline barium titanate (BaTiO3, henceforth BT) ceramics has been pursued with the aid of a microprobe polarized Raman spectrometer. The crystallographic texture and domain orientation distribution of BT ceramics, which switched upon applying stress according to ferroelasticity principles, were determined from the relative intensity of selected phonon modes, taking into consideration a theoretical analysis of the angular dependence of phonon mode intensity for the tetragonal BT phase. Furthermore, the angular dependence of Raman intensity measured in polycrystalline BT depended on the statistical distribution of domain angles in the laser microprobe, which was explicitly taken into account in this work for obtaining a quantitative analysis of domain orientation for in-plane textured BT polycrystalline materials.

Agile Data Curation: A conceptual framework and approach for practitioner data management

NASA Astrophysics Data System (ADS)

Young, J. W.; Benedict, K. K.; Lenhardt, W. C.

2015-12-01

Data management occurs across a range of science and related activities such as decision-support. Exemplars within the science community operate data management systems that are extensively planned before implementation, staffed with robust data management expertise, equipped with appropriate services and technologies, and often highly structured. However, this is not the only approach to data management and almost certainly not the typical experience. The other end of the spectrum is often an ad hoc practitioner team, with changing requirements, limited training in data management, and resource constrained for both equipment and human resources. Much of the existing data management literature serves the exemplar community and ignores the ad hoc practitioners. Somewhere in the middle are examples where data are repurposed for new uses thereby generating new data management challenges. This submission presents a conceptualization of an Agile Data Curation approach that provides foundational principles for data management efforts operating across the spectrum of data generation and use from large science systems to efforts with constrained resources, limited expertise, and evolving requirements. The underlying principles to Agile Data Curation are a reapplication of agile software development principles to data management. The historical reality for many data management efforts is operating in a practioner environment so Agile Data Curation utilizes historical and current case studies to validate the foundational principles and through comparison learn lessons for future application. This submission will provide an overview of the Agile Data Curation, cover the foundational principles to the approach, and introduce a framework for gathering, classifying, and applying lessons from case studies of practitioner data management.

40 CFR 60.4810 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

...)(1)(x) of this section. (i) Environmental concerns, including types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, sewage sludge feeding, and shutdown procedures...

40 CFR 60.2635 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) through (xi) of this section. (i) Environmental concerns, including types of emissions. (ii) Basic combustion principles, including products of combustion. (iii) Operation of the specific type of incinerator to be used by the operator, including proper startup, waste charging, and shutdown procedures. (iv...

Teaching Operant Conditioning at the Zoo.

ERIC Educational Resources Information Center

Lukas, Kristen E.; Marr, M. Jackson; Maple, Terry L.

1998-01-01

Describes a partnership between Zoo Atlanta and the Georgia Institute of Technology in teaching the principles of operant conditioning to students in an experimental psychology class. Maintains that the positive training techniques used in zoos are models of applied operant conditioning. Includes a discussion of zoo training goals. (MJP)

Private Pilot Ground School Course. Instructor's Guide.

ERIC Educational Resources Information Center

Schlenker, Richard M.

This manual consists of 10 lesson plans for use by instructors teaching a private pilot ground school course. Addressed in the individual lesson plans are the following topics: aerodynamics and principles of flight, flight instruments and systems, operational publications, regulations, airplane operations, engine operations, radio communications,…

Deficiencies in Indian Joint Operations

DTIC Science & Technology

2016-05-26

Pakistan Navy escorted its oil tankers along the Makran Coast to avoid a naval engagement. The key tasks for Operation Talwar included preventing... Informatics plays a major role in ensuring that intelligence is available in time and in the desired form. The US Principles of Joint Operations59 1

Principle and experimental investigation of current-driven negative-inductance superconducting quantum interference device

NASA Astrophysics Data System (ADS)

Li, Hao; Liu, Jianshe; Zhang, Yingshan; Cai, Han; Li, Gang; Liu, Qichun; Han, Siyuan; Chen, Wei

2017-03-01

A negative-inductance superconducting quantum interference device (nSQUID) is an adiabatic superconducting logic device with high energy efficiency, and therefore a promising building block for large-scale low-power superconducting computing. However, the principle of the nSQUID is not that straightforward and an nSQUID driven by voltage is vulnerable to common mode noise. We investigate a single nSQUID driven by current instead of voltage, and clarify the principle of the adiabatic transition of the current-driven nSQUID between different states. The basic logic operations of the current-driven nSQUID with proper parameters are simulated by WRspice. The corresponding circuit is fabricated with a 100 A cm-2 Nb-based lift-off process, and the experimental results at low temperature confirm the basic logic operations as a gated buffer.

Interpolatability distinguishes LOCC from separable von Neumann measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, Andrew M.; Leung, Debbie; Mančinska, Laura

2013-11-15

Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

[Evaluation of intraventricular dyssynchrony by quantitative tissue velocity imaging in rats of post-infarction heart failure].

PubMed

Wang, Yan; Zhu, Wenhui; Duan, Xingxing; Zhao, Yongfeng; Liu, Wengang; Li, Ruizhen

2011-04-01

To evaluate intraventricular systolic dyssynchrony in rats with post-infarction heart failure by quantitative tissue velocity imaging combining synchronous electrocardiograph. A total of 60 male SD rats were randomly assigned to 3 groups: a 4 week post-operative group and an 8 week post-operation group (each n=25, with anterior descending branch of the left coronary artery ligated), and a sham operation group (n=10, with thoracotomy and open pericardium, but no ligation of the artery). The time to peak systolic velocity of regional myocardial in the rats was measured and the index of the left intraventricular dyssynchrony was calculated. All indexes of the heart function became lower as the heart failure worsened except the left ventricle index in the post-operative groups. All indexes of the dyssynchrony got longer in the post-operative groups (P<0.05), while the changes in the sham operation group were not significantly different (P>0.05). Quantitative tissue velocity imaging combining synchronous electrocardiograph can analyse the intraventricular systolic dyssynchrony accurately.

Highly sensitive detection of the group A Rotavirus using Apolipoprotein H-coated ELISA plates compared to quantitative real-time PCR.

PubMed

Adlhoch, Cornelia; Kaiser, Marco; Hoehne, Marina; Mas Marques, Andreas; Stefas, Ilias; Veas, Francisco; Ellerbrok, Heinz

2011-02-10

The principle of a capture ELISA is binding of specific capture antibodies (polyclonal or monoclonal) to the surface of a suitable 96 well plate. These immobilized antibodies are capable of specifically binding a virus present in a clinical sample. Subsequently, the captured virus is detected using a specific detection antibody. The drawback of this method is that a capture ELISA can only function for a single virus captured by the primary antibody. Human Apolipoprotein H (ApoH) or β2-glycoprotein 1 is able to poly-specifically bind viral pathogens. Replacing specific capture antibodies by ApoH should allow poly-specific capture of different viruses that subsequently could be revealed using specific detection antibodies. Thus, using a single capture ELISA format different viruses could be analysed depending on the detection antibody that is applied. In order to demonstrate that this is a valid approach we show detection of group A rotaviruses from stool samples as a proof of principle for a new method of capture ELISA that should also be applicable to other viruses. Stool samples of different circulating common human and potentially zoonotic group A rotavirus strains, which were pretested in commercial EIAs and genotyped by PCR, were tested in parallel in an ApoH-ELISA set-up and by quantitative real-time PCR (qPCR). Several control samples were included in the analysis. The ApoH-ELISA was suitable for the capture of rotavirus-particles and the detection down to 1,000 infectious units (TCID(50/ml)). Subsets of diagnostic samples of different G- and P-types were tested positive in the ApoH-ELISA in different dilutions. Compared to the qPCR results, the analysis showed high sensitivity, specificity and low cross-reactivity for the ApoH-ELISA, which was confirmed in receiver operating characteristics (ROC) analysis. In this study the development of a highly sensitive and specific capture ELISA was demonstrated by combining a poly-specific ApoH capture step with specific detection antibodies using group A rotaviruses as an example.

Agile: From Software to Mission System

NASA Technical Reports Server (NTRS)

Trimble, Jay; Shirley, Mark H.; Hobart, Sarah Groves

2016-01-01

The Resource Prospector (RP) is an in-situ resource utilization (ISRU) technology demonstration mission, designed to search for volatiles at the Lunar South Pole. This is NASA's first near real time tele-operated rover on the Moon. The primary objective is to search for volatiles at one of the Lunar Poles. The combination of short mission duration, a solar powered rover, and the requirement to explore shadowed regions makes for an operationally challenging mission. To maximize efficiency and flexibility in Mission System design and thus to improve the performance and reliability of the resulting Mission System, we are tailoring Agile principles that we have used effectively in ground data system software development and applying those principles to the design of elements of the mission operations system.

Accurate atomistic first-principles calculations of electronic stopping

DOE PAGES

Schleife, André; Kanai, Yosuke; Correa, Alfredo A.

2015-01-20

In this paper, we show that atomistic first-principles calculations based on real-time propagation within time-dependent density functional theory are capable of accurately describing electronic stopping of light projectile atoms in metal hosts over a wide range of projectile velocities. In particular, we employ a plane-wave pseudopotential scheme to solve time-dependent Kohn-Sham equations for representative systems of H and He projectiles in crystalline aluminum. This approach to simulate nonadiabatic electron-ion interaction provides an accurate framework that allows for quantitative comparison with experiment without introducing ad hoc parameters such as effective charges, or assumptions about the dielectric function. Finally, our work clearlymore » shows that this atomistic first-principles description of electronic stopping is able to disentangle contributions due to tightly bound semicore electrons and geometric aspects of the stopping geometry (channeling versus off-channeling) in a wide range of projectile velocities.« less

Fuel cells: A survey

NASA Technical Reports Server (NTRS)

Crowe, B. J.

1973-01-01

A survey of fuel cell technology and applications is presented. The operating principles, performance capabilities, and limitations of fuel cells are discussed. Diagrams of fuel cell construction and operating characteristics are provided. Photographs of typical installations are included.

A shut-off valve for flexible tubing

NASA Technical Reports Server (NTRS)

Reyburn, W. W.

1972-01-01

Design of light weight valve for flexible tubing is described. Valve is hand operated and provides positive sealing in normally closed position. Diagram is provided to show construction of valve. Principles of operation are explained.

Evaluation of losses in transmission of machinery for development of mineral deposits in conditions of variable load

NASA Astrophysics Data System (ADS)

Zvonarev, I. E.; Ivanov, S. L.

2017-10-01

The influence of individual elements of machines transmissions on the operation of the whole system is shown. The approach of determining the resource of operation of systems elements based on the energy theory is presented. The formulas for determining the total energy resource of the reducer are given. The influence of individual elements of the system on each other is indicated. The principle of researching the system by the method of equivalent circuits is substantiated. The weakest places of transmission (gears, bearing supports and shafts) are determined. A mathematical model of a mechanical transmission was developed. To test the adequacy of the mathematical model, the stand for obtaining experimental data was designed. The description of the stand and the principle of its operation are given. Experimental data are presented. A comparative analysis of modeling and experimental data is carried out and the adequacy of the developed mathematical model is proved. The principle of determining the resource of the system as a whole for the element with the minimal resource of work is suggested.

The effects of type of knowledge upon human problem solving in a process control task

NASA Technical Reports Server (NTRS)

Morris, N. M.; Rouse, W. B.

1985-01-01

The question of what the operator of a dynamic system needs to know was investigated in an experiment using PLANT, a simulation of a generic dynamic production process. Knowledge of PLANT was manipulated via different types of instruction, so that four different groups were created: (1) minimal instructions only; (2) minimal instructions and guidelines for operation (procedures); (3) minimal instructions and dynamic relationships (principles); and (4) minimal instructions, and procedures, and principles. Subjects controlled PLANT in a variety of situations which required maintaining production while also diagnosing familiar and unfamiliar failures. Despite the fact that these manipulations resulted in differences in subjects' Knowledge, as assessed via a written test at the end of the experiment, instructions had no effect upon achievement of the primary goal of production, or upon subjects' ability to diagnose unfamiliar failures. However, those groups receiving procedures controlled the system in a more stable manner. Possible reasons for the failure to find an effect of principles are presented, and the implications of these results for operator training and aiding are discussed.

Single-Atom Demonstration of the Quantum Landauer Principle

NASA Astrophysics Data System (ADS)

Yan, L. L.; Xiong, T. P.; Rehan, K.; Zhou, F.; Liang, D. F.; Chen, L.; Zhang, J. Q.; Yang, W. L.; Ma, Z. H.; Feng, M.

2018-05-01

One of the outstanding challenges to information processing is the eloquent suppression of energy consumption in the execution of logic operations. The Landauer principle sets an energy constraint in deletion of a classical bit of information. Although some attempts have been made to experimentally approach the fundamental limit restricted by this principle, exploring the Landauer principle in a purely quantum mechanical fashion is still an open question. Employing a trapped ultracold ion, we experimentally demonstrate a quantum version of the Landauer principle, i.e., an equality associated with the energy cost of information erasure in conjunction with the entropy change of the associated quantized environment. Our experimental investigation substantiates an intimate link between information thermodynamics and quantum candidate systems for information processing.

Semiselective Optoelectronic Sensors for Monitoring Microbes

NASA Technical Reports Server (NTRS)

Tabacco, Mary Beth; Chuang, Han; Taylor,Laura; Russo, Jaime

2003-01-01

Sensor systems are under development for use in real-time detection and quantitation of microbes in water without need for sampling. These systems include arrays of optical sensors; miniature, portable electronic data-acquisition circuits; and optoelectronic interfaces between the sensor arrays and data-acquisition circuits. These systems are intended for original use in long-term, inline monitoring of waterborne micro-organisms in water-reclamation systems aboard future spacecraft. They could also be adapted to similar terrestrial uses with respect to municipal water supplies, stored drinking water, and swimming water; for detecting low-level biological contamination in biotechnological, semiconductor, and pharmaceutical process streams; and in verifying the safety of foods and beverages. In addition, they could be adapted to monitoring of airborne microbes and of surfaces (e.g., to detect and/or quantitate biofilms). The designs of the sensors in these systems are based partly on those of sensors developed previously for monitoring airborne biological materials. The designs exploit molecular- recognition and fluorescence-spectroscopy techniques, such that in the presence of micro-organisms of interest, fluorescence signals change and the changes can be measured. These systems are characterized as semiselective because they respond to classes of micro-organisms and can be used to discriminate among the classes. This semiselectivity is a major aspect of the design: It is important to distinguish between (1) the principle of detection and quantitation of classes of micro-organisms by use of these sensors and (2) the principle of detection and quantitation of individual microbiological species by means of prior immuno-diagnostic and/or molecular-biology techniques. Detection of classes (in contradistinction to species) is particularly valuable when the exact nature of a contaminant is unknown.

Acquisition of the novel name-nameless category (N3C) principle by young children who have Down syndrome.

PubMed

Mervis, C B; Bertrand, J

1995-11-01

Acquisition of the novel name-nameless category (N3C) principle by 22 children with Down syndrome between the ages of 2.42 and 3.33 years was examined to investigate the generalizability of a new approach to early lexical development: the developmental lexical principles framework. Results indicated that, as predicted, the N3C principle (operationally defined as the ability to fast map a new word to a [basic level] category), is not available at the start of lexical acquisition. The predicted link between ability to use the N3C principle and ability to perform exhaustive categorization of objects was supported. Children who used the principle had significantly larger productive vocabularies than did those who did not and, according to maternal report, had begun to acquire new words rapidly.

Virtual reality in surgical education.

PubMed

Ota, D; Loftin, B; Saito, T; Lea, R; Keller, J

1995-03-01

Virtual reality (VR) is an emerging technology that can teach surgeons new procedures and can determine their level of competence before they operate on patients. Also VR allows the trainee to return to the same procedure or task several times later as a refresher course. Laparoscopic surgery is a new operative technique which requires the surgeon to observe the operation on a video-monitor and requires the acquisition of new skills. VR simulation could duplicate the operative field and thereby enhance training and reduce the need for expensive animal training models. Our preliminary experience has shown that we have the technology to model tissues and laparoscopic instruments and to develop in real time a VR learning environment for surgeons. Another basic need is to measure competence. Surgical training is an apprenticeship requiring close supervision and 5-7 years of training. Technical competence is judged by the mentor and has always been subjective. If VR surgical simulators are to play an important role in the future, quantitative measurement of competence would have to be part of the system. Because surgical competence is "vague" and is characterized by such terms as "too long, too short" or "too close, too far," it is possible that the principles of fuzzy logic could be used to measure competence in a VR surgical simulator. Because a surgical procedure consists of a series of tasks and each task is a series of steps, we will plan to create two important tasks in a VR simulator and validate their use. These tasks consist of laparoscopic knot tying and laparoscopic suturing. Our hypothesis is that VR in combination with fuzzy logic can educate surgeons and determine when they are competent to perform these procedures on patients.

Principles of Design And Operations Of Wastewater Treatment Pond Systems For Plant Operators, Engineers, And Managers

EPA Science Inventory

Wastewater pond systems provide reliable, low cost, and relatively low maintenance treatment for municipal and industrial discharges. However, they do have certain design, operations, and maintenance requirements. While the basic models have not changed in the 30-odd years sinc...

Specification and Verification of Secure Concurrent and Distributed Software Systems

DTIC Science & Technology

1992-02-01

primitive search strategies work for operating systems that contain relatively few operations . As the number of operations increases, so does the the...others have granted him access to, etc . The burden of security falls on the operating system , although appropriate hardware support can minimize the...Guttag, J. Horning, and R. Levin. Synchronization primitives for a multiprocessor: a formal specification. Symposium on Operating System Principles

The State-Society/Citizen Relationship in Security Analysis: Implications for Planning and Implementation of U.S. Intervention and Peace/State-Building Operations

DTIC Science & Technology

2015-04-01

of the state. Such threats may come into existence when 9 the organizing principles of two states contradict each other in a context where the...security is that the normal condition of actors in a market econ - omy is one of risk, competition, and uncertainty.12 In other words, the actors in the...liberal principles , federative states have no natural unifying principle and, consequently, are more vulnerable to dismemberment, separatism, and

Applying principles from safety science to improve child protection.

PubMed

Cull, Michael J; Rzepnicki, Tina L; O'Day, Kathryn; Epstein, Richard A

2013-01-01

Child Protective Services Agencies (CPSAs) share many characteristics with other organizations operating in high-risk, high-profile industries. Over the past 50 years, industries as diverse as aviation, nuclear power, and healthcare have applied principles from safety science to improve practice. The current paper describes the rationale, characteristics, and challenges of applying concepts from the safety culture literature to CPSAs. Preliminary efforts to apply key principles aimed at improving child safety and well-being in two states are also presented.

Principles of quantitation of viral loads using nucleic acid sequence-based amplification in combination with homogeneous detection using molecular beacons.

PubMed

Weusten, Jos J A M; Carpay, Wim M; Oosterlaken, Tom A M; van Zuijlen, Martien C A; van de Wiel, Paul A

2002-03-15

For quantitative NASBA-based viral load assays using homogeneous detection with molecular beacons, such as the NucliSens EasyQ HIV-1 assay, a quantitation algorithm is required. During the amplification process there is a constant growth in the concentration of amplicons to which the beacon can bind while generating a fluorescence signal. The overall fluorescence curve contains kinetic information on both amplicon formation and beacon binding, but only the former is relevant for quantitation. In the current paper, mathematical modeling of the relevant processes is used to develop an equation describing the fluorescence curve as a function of the amplification time and the relevant kinetic parameters. This equation allows reconstruction of RNA formation, which is characterized by an exponential increase in concentrations as long as the primer concentrations are not rate limiting and by linear growth over time after the primer pool is depleted. During the linear growth phase, the actual quantitation is based on assessing the amplicon formation rate from the viral RNA relative to that from a fixed amount of calibrator RNA. The quantitation procedure has been successfully applied in the NucliSens EasyQ HIV-1 assay.

A Dimensionally Reduced Clustering Methodology for Heterogeneous Occupational Medicine Data Mining.

PubMed

Saâdaoui, Foued; Bertrand, Pierre R; Boudet, Gil; Rouffiac, Karine; Dutheil, Frédéric; Chamoux, Alain

2015-10-01

Clustering is a set of techniques of the statistical learning aimed at finding structures of heterogeneous partitions grouping homogenous data called clusters. There are several fields in which clustering was successfully applied, such as medicine, biology, finance, economics, etc. In this paper, we introduce the notion of clustering in multifactorial data analysis problems. A case study is conducted for an occupational medicine problem with the purpose of analyzing patterns in a population of 813 individuals. To reduce the data set dimensionality, we base our approach on the Principal Component Analysis (PCA), which is the statistical tool most commonly used in factorial analysis. However, the problems in nature, especially in medicine, are often based on heterogeneous-type qualitative-quantitative measurements, whereas PCA only processes quantitative ones. Besides, qualitative data are originally unobservable quantitative responses that are usually binary-coded. Hence, we propose a new set of strategies allowing to simultaneously handle quantitative and qualitative data. The principle of this approach is to perform a projection of the qualitative variables on the subspaces spanned by quantitative ones. Subsequently, an optimal model is allocated to the resulting PCA-regressed subspaces.

Reducible or irreducible? Mathematical reasoning and the ontological method.

PubMed

Fisher, William P

2010-01-01

Science is often described as nothing but the practice of measurement. This perspective follows from longstanding respect for the roles mathematics and quantification have played as media through which alternative hypotheses are evaluated and experience becomes better managed. Many figures in the history of science and psychology have contributed to what has been called the "quantitative imperative," the demand that fields of study employ number and mathematics even when they do not constitute the language in which investigators think together. But what makes an area of study scientific is, of course, not the mere use of number, but communities of investigators who share common mathematical languages for exchanging quantitative and quantitative value. Such languages require rigorous theoretical underpinning, a basis in data sufficient to the task, and instruments traceable to reference standard quantitative metrics. The values shared and exchanged by such communities typically involve the application of mathematical models that specify the sufficient and invariant relationships necessary for rigorous theorizing and instrument equating. The mathematical metaphysics of science are explored with the aim of connecting principles of quantitative measurement with the structures of sufficient reason.

The concept of "buffering" in systems and control theory: from metaphor to math.

PubMed

Schmitt, Bernhard M

2004-10-04

The paradigm of "buffering" is used increasingly for the description of diverse "systemic" phenomena encountered in evolutionary genetics, ecology, integrative physiology, and other areas. However, in this new context, the paradigm has not yet matured into a truly quantitative concept inasmuch as it lacks a corresponding quantitative measure of "systems-level buffering strength". Here, I develop such measures on the basis of a formal and general approach to the quantitation of buffering action. "Systems-level buffering" is shown to be synonymous with "disturbance rejection" in feedback-control systems, and can be quantitated by means of dimensionless proportions between partial flows in two-partitioned systems. The units allow either the time-independent, "static" buffering properties or the time-dependent, "dynamic" ones to be measured. Analogous to this "resistance to change", one can define and measure the "conductance to change"; this quantity corresponds to "set-point tracking" in feedback-control systems. Together, these units provide a systematic framework for the quantitation of buffering action in systems biology, and reveal the common principle behind systems-level buffering, classical acid-base buffering, and multiple other manifestations of buffering.

Principles for valid histopathologic scoring in research

PubMed Central

Gibson-Corley, Katherine N.; Olivier, Alicia K.; Meyerholz, David K.

2013-01-01

Histopathologic scoring is a tool by which semi-quantitative data can be obtained from tissues. Initially, a thorough understanding of the experimental design, study objectives and methods are required to allow the pathologist to appropriately examine tissues and develop lesion scoring approaches. Many principles go into the development of a scoring system such as tissue examination, lesion identification, scoring definitions and consistency in interpretation. Masking (a.k.a. “blinding”) of the pathologist to experimental groups is often necessary to constrain bias and multiple mechanisms are available. Development of a tissue scoring system requires appreciation of the attributes and limitations of the data (e.g. nominal, ordinal, interval and ratio data) to be evaluated. Incidence, ordinal and rank methods of tissue scoring are demonstrated along with key principles for statistical analyses and reporting. Validation of a scoring system occurs through two principal measures: 1) validation of repeatability and 2) validation of tissue pathobiology. Understanding key principles of tissue scoring can help in the development and/or optimization of scoring systems so as to consistently yield meaningful and valid scoring data. PMID:23558974

PROFIT-MAXIMIZING PRINCIPLES, INSTRUCTIONAL UNITS FOR VOCATIONAL AGRICULTURE.

ERIC Educational Resources Information Center

BARKER, RICHARD L.

THE PURPOSE OF THIS GUIDE IS TO ASSIST VOCATIONAL AGRICULTURE TEACHERS IN STIMULATING JUNIOR AND SENIOR HIGH SCHOOL STUDENT THINKING, UNDERSTANDING, AND DECISION MAKING AS ASSOCIATED WITH PROFIT-MAXIMIZING PRINCIPLES OF FARM OPERATION FOR USE IN FARM MANAGEMENT. IT WAS DEVELOPED UNDER A U.S. OFFICE OF EDUCATION GRANT BY TEACHER-EDUCATORS, A FARM…

Perceptual Organization of Visual Structure Requires a Flexible Learning Mechanism

ERIC Educational Resources Information Center

Aslin, Richard N.

2011-01-01

Bhatt and Quinn (2011) provide a compelling and comprehensive review of empirical evidence that supports the operation of principles of perceptual organization in young infants. They also have provided a comprehensive list of experiences that could serve to trigger the learning of at least some of these principles of perceptual organization, and…

The Principle of Cognitive Consistency and Central American Policy: A Comparison of the Carter and Reagan Administrations.

ERIC Educational Resources Information Center

Holland, Lynn

The principle of cognitive consistency, formulated by Jack Snyder, explains decision-making under stressful conditions. Snyder contends that decision-making under stressful conditions creates a drive toward cognitive consistency and brings into operation tendencies: (1) toward a perception of certainty about an opponent's intention and the…

A Wiki Collaboration to Create National Guidelines: Tips for Professional Practice

ERIC Educational Resources Information Center

Moser, Patt

2009-01-01

In 2006, technology directors from independent schools across the country had banded together and created "Principles of Good Practice" for technology in independent schools. These principles "define high standards and ethical behavior in key areas of independent school operations" (NAIS 2006). This author decided that it was time for the National…

75 FR 60745 - Availability of the Bonneville Purchasing Instructions (BPI) and Bonneville Financial Assistance...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

... Federal Power Marketing Agency in the Pacific Northwest. BPA operations are financed from power revenues... financial assistance policy. The BFAI also comprise BPA's rules governing implementation of the principles provided in the following Federal Regulations and/or OMB circulars: 2 CFR Part 220 Cost Principles for...

47 CFR 76.1504 - Rates, terms and conditions for carriage on open video systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

....1504 Rates, terms and conditions for carriage on open video systems. (a) Reasonable rate principle. An... operator will bear the burden of proof to demonstrate, using the principles set forth below, that the...; (2) Packaging, including marketing and other fees; (3) Talent fees; and (4) A reasonable overhead...

Clean room technology in surgery suites

NASA Technical Reports Server (NTRS)

1971-01-01

The principles of clean room technology and the criteria for their application to surgery are discussed. The basic types of surgical clean rooms are presented along with their advantages and disadvantages. Topics discussed include: microbiology of surgery suites; principles of laminar airflow systems, and their use in surgery; and asepsis and the operating room.

A Framework for Developing Sustainable E-Learning Programmes

ERIC Educational Resources Information Center

Chipere, Ngoni

2017-01-01

A framework was created at the University of the West Indies to guide the development of 18 e-learning programmes. The framework is based on three principles for sustainable e-learning design: (1) stakeholder-centredness; (2) cost-effectiveness and (3) high operational efficiency. These principles give rise to nine framework elements: (1) a labour…

Risk analysis of heat recovery steam generator with semi quantitative risk based inspection API 581

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prayogo, Galang Sandy, E-mail: gasandylang@live.com; Haryadi, Gunawan Dwi; Ismail, Rifky

Corrosion is a major problem that most often occurs in the power plant. Heat recovery steam generator (HRSG) is an equipment that has a high risk to the power plant. The impact of corrosion damage causing HRSG power plant stops operating. Furthermore, it could be threaten the safety of employees. The Risk Based Inspection (RBI) guidelines by the American Petroleum Institute (API) 58 has been used to risk analysis in the HRSG 1. By using this methodology, the risk that caused by unexpected failure as a function of the probability and consequence of failure can be estimated. This paper presentedmore » a case study relating to the risk analysis in the HRSG, starting with a summary of the basic principles and procedures of risk assessment and applying corrosion RBI for process industries. The risk level of each HRSG equipment were analyzed: HP superheater has a medium high risk (4C), HP evaporator has a medium-high risk (4C), and the HP economizer has a medium risk (3C). The results of the risk assessment using semi-quantitative method of standard API 581 based on the existing equipment at medium risk. In the fact, there is no critical problem in the equipment components. Damage mechanisms were prominent throughout the equipment is thinning mechanism. The evaluation of the risk approach was done with the aim of reducing risk by optimizing the risk assessment activities.« less

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

PubMed Central

Iyer, Janani; Wang, Qingyu; Le, Thanh; Pizzo, Lucilla; Grönke, Sebastian; Ambegaokar, Surendra S.; Imai, Yuzuru; Srivastava, Ashutosh; Troisí, Beatriz Llamusí; Mardon, Graeme; Artero, Ruben; Jackson, George R.; Isaacs, Adrian M.; Partridge, Linda; Lu, Bingwei; Kumar, Justin P.; Girirajan, Santhosh

2016-01-01

About two-thirds of the vital genes in the Drosophila genome are involved in eye development, making the fly eye an excellent genetic system to study cellular function and development, neurodevelopment/degeneration, and complex diseases such as cancer and diabetes. We developed a novel computational method, implemented as Flynotyper software (http://flynotyper.sourceforge.net), to quantitatively assess the morphological defects in the Drosophila eye resulting from genetic alterations affecting basic cellular and developmental processes. Flynotyper utilizes a series of image processing operations to automatically detect the fly eye and the individual ommatidium, and calculates a phenotypic score as a measure of the disorderliness of ommatidial arrangement in the fly eye. As a proof of principle, we tested our method by analyzing the defects due to eye-specific knockdown of Drosophila orthologs of 12 neurodevelopmental genes to accurately document differential sensitivities of these genes to dosage alteration. We also evaluated eye images from six independent studies assessing the effect of overexpression of repeats, candidates from peptide library screens, and modifiers of neurotoxicity and developmental processes on eye morphology, and show strong concordance with the original assessment. We further demonstrate the utility of this method by analyzing 16 modifiers of sine oculis obtained from two genome-wide deficiency screens of Drosophila and accurately quantifying the effect of its enhancers and suppressors during eye development. Our method will complement existing assays for eye phenotypes, and increase the accuracy of studies that use fly eyes for functional evaluation of genes and genetic interactions. PMID:26994292

Improving Scotland's health: time for a fresh approach?

PubMed

Stone, D H

2012-05-01

Scotland's health remains the worst in the UK. There are several probable reasons for this. Of those that are amenable to change, health improvement policy has been excessively preoccupied with targeting individuals perceived to be 'at risk' rather than adopting a whole population perspective. Environmental as opposed to behavioural approaches to health improvement have been relatively neglected. To meet the challenge of Scotland's poor health more effectively in the future, new strategic thinking is necessary. Three initial steps are required: recognize that current approaches are inadequate and that fresh ideas are needed; identify the principles that should underlie future strategy development; translate these principles into achievable operational objectives. Five principles of a revitalized strategy to improve the health of Scotland in the future are proposed. These are start early and sustain effort; create a healthy and safe environment; reduce geographical as well as social inequalities in health; adopt an evidence-based approach to public health interventions; use epidemiology to assess need, plan interventions and monitor progress. These principles may then be translated into achievable operational policy and practice objectives.

Restoring the Pauli principle in the random phase approximation ground state

NASA Astrophysics Data System (ADS)

Kosov, D. S.

2017-12-01

Random phase approximation ground state contains electronic configurations where two (and more) identical electrons can occupy the same molecular spin-orbital violating the Pauli exclusion principle. This overcounting of electronic configurations happens due to quasiboson approximation in the treatment of electron-hole pair operators. We describe the method to restore the Pauli principle in the RPA wavefunction. The proposed theory is illustrated by the calculations of molecular dipole moments and electronic kinetic energies. The Hartree-Fock based RPA, which is corrected for the Pauli principle, gives the results of comparable accuracy with Møller-Plesset second order perturbation theory and coupled-cluster singles and doubles method.

"We need our own food, to grow our own veggies…" Remote Aboriginal food gardens in the Top End of Australia's Northern Territory.

PubMed

Hume, Andrew; O'Dea, Kerin; Brimblecombe, Julie

2013-10-01

Remote Aboriginal community gardens (gardens) frequently operate below their full potential. A set of gardening sustainability principles may improve their planning, operation and long-term sustainability. This paper aims to document the principles of sustainability of non-profit remote Aboriginal community gardens in the Top End of the Northern Territory. Throughout 2011, gardens in the Top End of the Northern Territory were visited. Interviews and observational data were used to explore the principles of garden sustainability with participants. Subsequent iterative thematic analysis informed development of a set of gardening sustainability principles. Principles of sustainability included effective garden planning; community autonomy, consultation and engagement; growing community vetted crops; employing long-term, effective, culturally sensitive managers; long-term, transparent funding organisations and cycles; garden integration into existing food supply chains; culturally appropriate employment arrangements; and physical aspects of successful gardening. This work uniquely consults gardeners, managers and Aboriginal and non-Aboriginal people of both genders in the largest reported study of its type, resulting in new and expanded findings, particularly including new social factors for gardening success. Expanding the understanding of what makes gardens work to include the important social factors identified here may have merit. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

Ten financial management principles for survival.

PubMed

Cleverley, W O

1988-03-01

Financial insolvency is the primary cause of hospital failure. Managers may analyze a hospital's financial statements to anticipate and prevent fiscal problems. Ten measures of fiscal status may be used to evaluate the following: operating profitability nonoperating income equity growth liquidity debt capacity age of facilities revenue generation replacement funds receivables survivability Based on data from the Financial Analysis Service, Catholic hospitals are doing better than other U.S. hospitals in some areas of financial preparedness. In most areas, however, all hospitals suffer by comparison with manufacturers. The 10 principles of solvent and successful operations can help hospitals improve financial resiliency.

Beyond Moore’s technologies: operation principles of a superconductor alternative

PubMed Central

Klenov, Nikolay V; Bakurskiy, Sergey V; Kupriyanov, Mikhail Yu; Gudkov, Alexander L; Sidorenko, Anatoli S

2017-01-01

The predictions of Moore’s law are considered by experts to be valid until 2020 giving rise to “post-Moore’s” technologies afterwards. Energy efficiency is one of the major challenges in high-performance computing that should be answered. Superconductor digital technology is a promising post-Moore’s alternative for the development of supercomputers. In this paper, we consider operation principles of an energy-efficient superconductor logic and memory circuits with a short retrospective review of their evolution. We analyze their shortcomings in respect to computer circuits design. Possible ways of further research are outlined. PMID:29354341

Terahertz detection using double quantum well devices

NASA Astrophysics Data System (ADS)

Khodier, Majid; Christodoulou, Christos G.; Simmons, Jerry A.

2001-12-01

This paper discusses the principle of operation of an electrically tunable THz detector, working around 2.54 THz, integrated with a bowtie antenna. The detection is based on the idea of photon-assisted tunneling (PAT) in a double quantum well (DQW) device. The bowtie antenna is used to collect the THz radiation and feed it to the detector for processing. The Bowtie antenna geometry is integrated with the DQW device to achieve broadband characteristic, easy design, and compatibility with the detector fabrication process. The principle of operation of the detector is introduced first. Then, results of different bowtie antenna layouts are presented and discussed.

DC motor proportional control system for orthotic devices

NASA Technical Reports Server (NTRS)

Blaise, H. T.; Allen, J. R.

1972-01-01

Multi-channel proportional control system for operation of dc motors for use with externally-powered orthotic arm braces is described. Components of circuitry and principles of operation are described. Schematic diagram of control circuit is provided.

Two-Photon Fluorescence Microscopy for Biomedical Research

NASA Technical Reports Server (NTRS)

Fischer, David; Zimmerli, Greg; Asipauskas, Marius

2007-01-01

This viewgraph presentation gives an overview of two-photon microscopy as it applies to biomedical research. The topics include: 1) Overview; 2) Background; 3) Principles of Operation; 4) Advantages Over Confocal; 5) Modes of Operation; and 6) Applications.

The utilization of the seven principles for good practices of full-time and adjunct faculty in teaching health & science in community colleges

NASA Astrophysics Data System (ADS)

Musaitif, Linda M.

Purpose. The purpose of this study was to determine the degree to which undergraduate full-time and adjunct faculty members in the health and science programs at community colleges in Southern California utilize the seven principles of good practice as measured by the Faculty Inventory of the Seven Principles for Good Practice in Undergraduate Education. A second purpose was to compare degree of utilization for gender and class size. Methodology. This is a quantitative study wherein there exists a systematic and mathematical assessment of data gathered through the use of a Likert scale survey to process and determine the mathematical model of the use of the principles by the target population of both full-time and adjunct faculty of health/science programs of community colleges in Southern California. Findings. Examination of the data revealed that both full-time and adjunct faculty members of Southern California community colleges perceive themselves a high degree of utilization of the seven principles of good practice. There was no statistically significant data to suggest a discrepancy between full-time and adjunct professors' perceptions among the utilization of the seven principles. Overall, male faculty members perceived themselves as utilizing the principles to a greater degree than female faculty. Data suggest that faculty with class size 60 or larger showed to utilize the seven principles more frequently than the professors with smaller class sizes. Conclusions. Full-time and adjunct professors of the health and sciences in Southern California community colleges perceive themselves as utilizing the seven principles of good practice to a high degree. Recommendations. This study suggests many recommendations for future research, including the degree to which negative economic factors such as budget cuts and demands affect the utilization of the seven principles. Also recommended is a study comparing students' perceptions of faculty's utilization of the seven principles of good practice in the classroom with faculty's self-perception.

Overview of Loop Heat Pipe Operation

NASA Technical Reports Server (NTRS)

Ku, Jentung

1999-01-01

Loop heat pipes (LHP's) are two-phase heat transfer devices that utilize the evaporation and condensation of a working fluid to transfer heat, and the capillary forces developed in the porous wicks to circulate the fluid. The LHP was first developed in the former Soviet Union in the early 1980s, about the same time that the capillary pumped loop (CPL) was developed in the United States. The LHP is known for its high pumping capability and robust operation mainly due to the use of fine-pored metal wicks and an integral evaporator/hydro-accumulator design. The LHP technology is rapidly gaining acceptance in aerospace community. It is the baseline design for thermal control of several spacecraft, including NASA's GLAS and Chemistry, ESA's ATLID, CNES' STENTOR, RKA's OBZOR, and several commercial satellites. Numerous LHP papers have been published since the mid-1980's. Most papers presented test results and discussions on certain specific aspects of the LHP operation. LHP's and CPL's show many similarities in their operating principles and performance characteristics. However, they also display significant differences in many aspects of their operation. Some of the LHP behaviors may seem strange or mysterious, even to experienced CPL practitioners. The main purpose of this paper is to present a systematic description of the operating principles and thermal-hydraulic behaviors of LHP'S. LHP operating principles will be given first, followed by a description of the thermal-hydraulics involved in LHP operation. Operating characteristics and important parameters affecting the LHP operation will then be described in detail. Peculiar behaviors of the LHP, including temperature hysteresis and temperature overshoot during start-up, will be explained. For simplicity, most discussions will focus upon LHP's with a single evaporator and a single condenser, but devices with multiple evaporators and condensers will also be discussed. Similarities and differences between LHP's and CPL's will be addressed throughout the paper whenever appropriate.

Principle and Basic Characteristics of Variable-Magnetic-Force Memory Motors

NASA Astrophysics Data System (ADS)

Sakai, Kazuto; Yuki, Kazuaki; Hashiba, Yutaka; Takahashi, Norio; Yasui, Kazuya; Kovudhikulrungsri, Lilit

A reduction in the power consumed by motors is required for energy saving in the case of electrical appliances and electric vehicles (EV). The motors used for operating these apparatus operate at variable speeds. Further, the motors operate with small load in stationary mode and with large load in start-up mode. A permanent magnet motor can operate at the rated power with a high efficiency. However, the efficiency is lower at small load or high speed because the large constant magnetic force results in substantial core loss. Furthermore, the flux-weakening current that depresses voltage at high speed leads to significant copper loss. Therefore, we have developed a new technique for controlling the magnetic force of permanent magnet on the basis of the load or speed of the motor. In this paper, we propose the novel motor that can vary magnetic flux and we clarify the principle.

Stockholder projector analysis: A Hilbert-space partitioning of the molecular one-electron density matrix with orthogonal projectors

NASA Astrophysics Data System (ADS)

Vanfleteren, Diederik; Van Neck, Dimitri; Bultinck, Patrick; Ayers, Paul W.; Waroquier, Michel

2012-01-01

A previously introduced partitioning of the molecular one-electron density matrix over atoms and bonds [D. Vanfleteren et al., J. Chem. Phys. 133, 231103 (2010)] is investigated in detail. Orthogonal projection operators are used to define atomic subspaces, as in Natural Population Analysis. The orthogonal projection operators are constructed with a recursive scheme. These operators are chemically relevant and obey a stockholder principle, familiar from the Hirshfeld-I partitioning of the electron density. The stockholder principle is extended to density matrices, where the orthogonal projectors are considered to be atomic fractions of the summed contributions. All calculations are performed as matrix manipulations in one-electron Hilbert space. Mathematical proofs and numerical evidence concerning this recursive scheme are provided in the present paper. The advantages associated with the use of these stockholder projection operators are examined with respect to covalent bond orders, bond polarization, and transferability.

Smart spectroscopy sensors: II. Narrow-band laser systems

NASA Astrophysics Data System (ADS)

Matharoo, Inderdeep; Peshko, Igor

2013-03-01

This paper describes the principles of operation of a miniature multifunctional optical sensory system based on laser technology and spectroscopic principles of analysis. The operation of the system as a remote oxygen sensor has been demonstrated. The multi-component alarm sensor has been designed to recognise gases and to measure gas concentration (O2, CO2, CO, CH4, N2O, C2H2, HI, OH radicals and H2O vapour, including semi-heavy water), temperature, pressure, humidity, and background radiation from the environment. Besides gas sensing, the same diode lasers are used for range-finding and to provide sensor self-calibration. The complete system operates as an inhomogeneous sensory network: the laser sensors are capable of using information received from environmental sensors for improving accuracy and reliability of gas concentration measurement. The sources of measurement errors associated with hardware and algorithms of operation and data processing have been analysed in detail.

Male-male competition, female mate choice and their interaction: determining total sexual selection.

PubMed

Hunt, John; Breuker, Casper J; Sadowski, Jennifer A; Moore, Allen J

2009-01-01

Empirical studies of sexual selection typically focus on one of the two mechanisms of sexual selection without integrating these into a description of total sexual selection, or study total sexual selection without quantifying the contributions of all of the mechanisms of sexual selection. However, this can provide an incomplete or misleading view of how sexually selected traits evolve if the mechanisms of sexual selection are opposing or differ in form. Here, we take a two-fold approach to advocate a direction for future studies of sexual selection. We first show how a quantitative partitioning and examination of sexual selection mechanisms can inform by identifying illustrative studies that describe both male-male competition and female mate choice acting on the same trait. In our sample, the most common trait where this occurred was body size, and selection was typically linear. We found that male-male competition and female mate choice can be reinforcing or opposing, although the former is most common in the literature. The mechanisms of sexual selection can occur simultaneously or sequentially, and we found they were more likely to be opposing when the mechanisms operated sequentially. The degree and timing that these mechanisms interact have important implications for the operation of sexual selection and needs to be considered in designing studies. Our examples highlight where empirical data are needed. We especially lack standardized measures of the form and strength of selection imposed by each mechanism of sexual selection and how they combine to determine total sexual selection. Secondly, using quantitative genetic principles, we outline how the selection imposed by individual mechanisms can be measured and combined to estimate the total strength and form of sexual selection. We discuss the evolutionary consequences of combining the mechanisms of sexual selection and interpreting total sexual selection. We suggest how this approach may result in empirical progress in the field of sexual selection.

Statistical mechanical foundation of the peridynamic nonlocal continuum theory: energy and momentum conservation laws.

PubMed

Lehoucq, R B; Sears, Mark P

2011-09-01

The purpose of this paper is to derive the energy and momentum conservation laws of the peridynamic nonlocal continuum theory using the principles of classical statistical mechanics. The peridynamic laws allow the consideration of discontinuous motion, or deformation, by relying on integral operators. These operators sum forces and power expenditures separated by a finite distance and so represent nonlocal interaction. The integral operators replace the differential divergence operators conventionally used, thereby obviating special treatment at points of discontinuity. The derivation presented employs a general multibody interatomic potential, avoiding the standard assumption of a pairwise decomposition. The integral operators are also expressed in terms of a stress tensor and heat flux vector under the assumption that these fields are differentiable, demonstrating that the classical continuum energy and momentum conservation laws are consequences of the more general peridynamic laws. An important conclusion is that nonlocal interaction is intrinsic to continuum conservation laws when derived using the principles of statistical mechanics.

How Schools Can Effectively Plan to Meet the Goal of Improving Student Learning

ERIC Educational Resources Information Center

Grumdahl, Constance Rae

2010-01-01

Purpose. The purpose of the study was to identify the impact on achievement when schools implement a continuous improvement model using Total Quality Management (TQM) principles aligned to strategic planning and the culture of the school. Data collection and analysis. The study combined qualitative and quantitative methods and was conducted in two…

Qualitative Research in Educational Communications and Technology: A Brief Introduction to Principles and Procedures

ERIC Educational Resources Information Center

Neuman, Delia

2014-01-01

Over the past 30 years, qualitative research has emerged as a widely accepted alternative to the quantitative paradigm for performing research in educational communications and technology. As the new paradigm has evolved, it has spawned a variety of theoretical perspectives and methodological techniques that have both increased its potential…

Analytical capabilities and services of Lawrence Livermore Laboratory's General Chemistry Division. [Methods available at Lawrence Livermore

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gutmacher, R.; Crawford, R.

This comprehensive guide to the analytical capabilities of Lawrence Livermore Laboratory's General Chemistry Division describes each analytical method in terms of its principle, field of application, and qualitative and quantitative uses. Also described are the state and quantity of sample required for analysis, processing time, available instrumentation, and responsible personnel.

Trees and logs important to wildlife in the interior Columbia River basin.

Treesearch

Evelyn L. Bull; Catherine G. Parks; Torolf R. Torgersen

1997-01-01

This publication provides qualitative and quantitative information on five distinct structures: living trees with decayed parts, trees with hollow chambers, trees with brooms, dead trees, and logs. Information is provided on the value of these structures to wildlife, the decay or infection processes involved in the formation of these structures, and the principles to...

40 CFR Appendix C to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Carbon Monoxide in the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... through a cell containing the gas sample to be analyzed, and the quantitative absorption of energy by CO.... Environmental Protection Agency, Environmental Monitoring Systems Laboratory, Research Triangle Park, NC 27711..., Environmental Monitoring Systems Laboratory (MD-77), Research Triangle Park, NC 27711, January 1981. 50-732.eps...

40 CFR Appendix D to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Ozone in the Atmosphere

Code of Federal Regulations, 2014 CFR

2014-07-01

... carried out frequently, with all quantitative results or indications recorded in a chronological record..., National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park, NC 27711. 9.../4-79-057, EPA, National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park...

40 CFR Appendix C to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Carbon Monoxide in the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... through a cell containing the gas sample to be analyzed, and the quantitative absorption of energy by CO.... Environmental Protection Agency, Environmental Monitoring Systems Laboratory, Research Triangle Park, NC 27711..., Environmental Monitoring Systems Laboratory (MD-77), Research Triangle Park, NC 27711, January 1981. 50-732.eps...

40 CFR Appendix D to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Ozone in the Atmosphere

Code of Federal Regulations, 2013 CFR

2013-07-01

... carried out frequently, with all quantitative results or indications recorded in a chronological record..., National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park, NC 27711. 9.../4-79-057, EPA, National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park...

40 CFR Appendix D to Part 50 - Measurement Principle and Calibration Procedure for the Measurement of Ozone in the Atmosphere

Code of Federal Regulations, 2012 CFR

2012-07-01

... carried out frequently, with all quantitative results or indications recorded in a chronological record..., National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park, NC 27711. 9.../4-79-057, EPA, National Exposure Research Laboratory, Department E, (MD-77B), Research Triangle Park...

Using Mimio Boardcast in an Online Principles of Macroeconomics Course to Improve Student Performance

ERIC Educational Resources Information Center

Finlay, Nikki McIntyre; Deis, Michael H.

2005-01-01

The emergence of the speedily evolving world of technology has given many universities an interactive medium to facilitate teaching and learning. One such medium has been online courses, which have provided greater access to both traditional and non-traditional students. In quantitative courses such as economics, however, there are often concerns…

The Inevitable Corruption of Indicators and Educators through High-Stakes Testing

ERIC Educational Resources Information Center

Nichols, Sharon L.; Berliner, David C.

2005-01-01

This research provides lengthy proof of a principle of social science known as Campbell's law: "The more any quantitative social indicator is used for social decision-making, the more subject it will be to corruption pressures and the more apt it will be to distort and corrupt the social processes it is intended to monitor." Applying…

Fitting It All In: Adapting a Green Chemistry Extraction Experiment for Inclusion in an Undergraduate Analytical Laboratory

ERIC Educational Resources Information Center

Buckley, Heather L.; Beck, Annelise R.; Mulvihill, Martin J.; Douskey, Michelle C.

2013-01-01

Several principles of green chemistry are introduced through this experiment designed for use in the undergraduate analytical chemistry laboratory. An established experiment of liquid CO2 extraction of D-limonene has been adapted to include a quantitative analysis by gas chromatography. This facilitates drop-in incorporation of an exciting…

Racial Privilege in the Professoriate: An Exploration of Campus Climate, Retention, and Satisfaction

ERIC Educational Resources Information Center

Jayakumar, Uma M.; Howard, Tyrone C.; Allen, Walter R.; Han, June C.

2009-01-01

This study applies the principles of critical race theory to examine quantitatively the experiences of a national sample of 37,582 faculty. Among the key factors influencing retention and satisfaction are campus racial climate, autonomy and independence, and the review and promotion process. Results support the value of examining faculty of color…

Raising Student Achievement: A Closer Look into Magnet Schools

ERIC Educational Resources Information Center

Sanchez, Octavio

2010-01-01

The need to address social and economic changes has focused greater attention on our public education system and the need to better equip students with the skills needed for a global society. This quantitative study was grounded in the principles of the constructivist learning theory. The purpose of this study was to determine whether the added…

Teaching Inferential Statistics to Social Work Students: A Decision-Making Flow Chart

ERIC Educational Resources Information Center

Calderwood, Kimberly A.

2012-01-01

Given that social work research courses are typically built on modernist principles of teaching and content, it is not surprising that the majority of social work students dread these courses. Few attempts have been made to better align the modernist content of quantitative research with the postmodern philosophy and values inherent in current…