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Sample records for rad-by-rad bit-by-bit triumph

  1. BIT BY BIT: A Game Simulating Natural Language Processing in Computers

    ERIC Educational Resources Information Center

    Kato, Taichi; Arakawa, Chuichi

    2008-01-01

    BIT BY BIT is an encryption game that is designed to improve students' understanding of natural language processing in computers. Participants encode clear words into binary code using an encryption key and exchange them in the game. BIT BY BIT enables participants who do not understand the concept of binary numbers to perform the process of…

  2. Quantum leaps, bit by bit

    NASA Astrophysics Data System (ADS)

    Trabesinger, Andreas

    2017-03-01

    The promises of quantum computation are unique -- and so are the challenges. Progress in physics, mathematics, computer science and engineering have brought quantum computers to a point where they start to challenge their classical counterparts. By Andreas Trabesinger; illustration by Visual Science.

  3. Bit by bit: the Darwinian basis of life.

    PubMed

    Joyce, Gerald F

    2012-01-01

    All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered by the fact that the probability for life to originate is not known. As a guiding principle in parsing potential examples of alternative life, one should ask: How many heritable "bits" of information are involved, and where did they come from? A genetic system that contains more bits than the number that were required to initiate its operation might reasonably be considered a new form of life.

  4. We Come to Form Ourselves Bit by Bit: Educating for Citizenship in Post-Conflict Guatemala

    ERIC Educational Resources Information Center

    Rubin, Beth C.

    2016-01-01

    Over the past several decades, the implementation of democratic citizenship education has become a common prescription for the civic reconstruction of post-conflict societies. Across the globe, educational changes are seen as fundamental to the creation of peaceful, tolerant, and democratic civic identities, the key to "social reconstruction,…

  5. Bit by Bit: Innovating at the Periphery to Extend Harvard's Core

    ERIC Educational Resources Information Center

    Laserna, Catalina; Leitner, Henry

    2008-01-01

    Faculty instructional time is a critical resource at all universities, but particularly in a major research institution like Harvard. Operating on the periphery of the Faculty of Arts and Sciences, Harvard's division of Continuing Education is often at a disadvantage when attempting to recruit senior faculty. However, through its distance…

  6. Bit by Bit: Using Design-Based Research to Improve the Health Literacy of Adolescents

    PubMed Central

    St. Jean, Beth; Taylor, Natalie Greene; Kodama, Christie; Follman, Rebecca; Casciotti, Dana

    2015-01-01

    Background Although a low health literacy level has been found to be among the most powerful predictors of poor health outcomes, there is very little research focused on assessing and improving the health literacy skills of adolescents, particularly those from socioeconomically disadvantaged backgrounds. The vast majority of existing research focuses solely on reading comprehension, despite the fact that health literacy is actually a multifaceted concept, which entails many different types of skills. Objective The aim of this paper is to first mine existing literature to identify the many different skills that have been posited to constitute health literacy, and then, using this collection of skills as an overarching structure, to highlight the challenges that disadvantaged youth participating in our HackHealth after-school program encounter as they identify and articulate their health-related information needs, search for health-related information online, assess the relevance and credibility of this information, and manage and make use of it. Methods We utilized the design-based research method to design, implement, and revise our HackHealth program. To collect data regarding HackHealth participants’ health literacy skills and associated challenges, we used a variety of methods, including participant observation, surveys, interviews, focus groups, and logging of Web browser activities. We also collected data through specialized instructional activities and data collection forms that we developed for this purpose. Quantitative and qualitative techniques were used to analyze this data, as well as all of the artifacts that each student produced, including their final projects. Results We identified the various challenges that the 30 HackHealth participants faced in completing various health-related information activities during the course of the program. Based on these findings, we describe important implications for working with youth from socioeconomically disadvantaged backgrounds, how to assess and improve their health literacy skills, and offer specific recommendations for health literacy instruction aimed at this population. Conclusions With an increased societal focus on health and a shift from viewing patients as passive recipients of medical care to viewing them as active arbiters of their own health, today’s youth need to possess an array of health literacy skills to ensure that they can live long and healthy lives. Working with adolescents to help them develop and practice these skills will also help to break the cycle between poor health literacy and poor health outcomes, thereby reducing health disparities and improving the long-term outlook for the health of our nation. PMID:26025101

  7. Teaching Arturo Ui: Triumph of Whose Will?

    ERIC Educational Resources Information Center

    Rhiel, Mary

    1993-01-01

    Describes a unit on teaching Brecht in an introductory literature course, and suggests that students are better able to read and discuss Brecht's Hitler play if they first view and discuss Leni Riefenstahl's film Triumph of the Will. Guidelines are provided on how best to present and explore the two works with students. (LET)

  8. Oedipus and the sphinx: triumph and catastrophe.

    PubMed

    Palombo, S R

    1994-01-01

    The downfall of Oedipus in Sophocles' most famous play, Oedipus Tyrannus, is the reversal of his triumphant entry into the city of Thebes 17 years earlier. The oracle at Delphi has told the Thebans that the plague will end only when the murderer of Laius is identified and punished. The unconscious collusion between Oedipus and the Thebans to ignore the unsolved murder breaks down. Told by Teiresias that he is the culprit, Oedipus begins a desperate effort to find evidence to refute this accusation. When other witnesses come forward, his cause is lost. The effect of Oedipus's collusive interaction with the Thebans is balanced in Sophocles' account by the story of the riddle of the Sphinx. The Sphinx is a goddess of discontinuity. She represents the unconscious forces at work both in Oedipus's personal fantasies and in the collective fantasies of the Thebans. The tragedy results from the interaction of these fantasies in the government of the polis. Sophocles' play thus exemplifies the intricate intertwining of the child's innate wishes and the reaction they evoke from the environment during the oedipal period. The neurotic patient's illusion of sexual triumph over his or her father or mother as a child can be best understood through the interaction of these factors.

  9. Bit by Bit or All at Once? Splitting up the Inquiry Task to Promote Children's Scientific Reasoning

    ERIC Educational Resources Information Center

    Lazonder, Ard W.; Kamp, Ellen

    2012-01-01

    This study examined whether and why assigning children to a segmented inquiry task makes their investigations more productive. Sixty-one upper elementary-school pupils engaged in a simulation-based inquiry assignment either received a multivariable inquiry task (n = 21), a segmented version of this task that addressed the variables in successive…

  10. 8. VIEW OF 'TRIUMPH' CORN SHELLER (C. O. Bartlett & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF 'TRIUMPH' CORN SHELLER (C. O. Bartlett & Snow Co., Cleveland), LOCATED IN THE BASEMENT, USED TO REMOVE CORN KENNELS FROM THE COB. Photographer: Louise Taft Cawood, July 1986 - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

  11. The Pitfalls and Triumphs of Launching a Charter School.

    ERIC Educational Resources Information Center

    Page, Linda; Levine, Mark

    1996-01-01

    A principal of a charter school in Colorado Springs, Colorado, recounts the triumphs and pitfalls of the school's first year. The school charter lacked a clear-cut avenue for making changes. Intending to create a parent-run school, the founding board (themselves parents) made drastic curricular changes without consulting other parents. Passionate…

  12. Lifestyle Modification for Resistant Hypertension: The TRIUMPH Randomized Clinical Trial

    PubMed Central

    Blumenthal, James A.; Sherwood, Andrew; Smith, Patrick J.; Mabe, Stephanie; Watkins, Lana; Lin, Pao-Hwa; Craighead, Linda W.; Babyak, Michael; Tyson, Crystal; Young, Kenlyn; Ashworth, Megan; Kraus, William; Liao, Lawrence; Hinderliter, Alan

    2015-01-01

    Background Resistant hypertension (RH) is a growing health burden in this country affecting as many as one in five adults being treated for hypertension. RH is associated with increased risk of adverse cardiovascular disease (CVD) events and all-cause mortality. Strategies to reduce blood pressure in this high risk population are a national priority. Methods TRIUMPH is a single site, prospective, randomized clinical trial (RCT) to evaluate the efficacy of a center-based lifestyle intervention consisting of exercise training, reduced sodium and calorie DASH eating plan, and weight management compared to standardized education and physician advice in treating patients with RH. Patients (N=150) will be randomized in a 2:1 ratio to receive either a 4-month supervised lifestyle intervention delivered in the setting of a cardiac rehabilitation center or to a standardized behavioral counseling session to simulate real-world medical practice. The primary end point is clinic blood pressure; secondary endpoints include ambulatory blood pressure and an array of CVD biomarkers including left ventricular hypertrophy, arterial stiffness, baroreceptor reflex sensitivity, insulin resistance, lipids, sympathetic nervous system activity, and inflammatory markers. Lifestyle habits, blood pressure and CVD risk factors also will be measured at one year follow-up. Conclusions The TRIUMPH randomized clinical trial (ClinicalTrials.gov NCT02342808) is designed to test the efficacy of an intensive, center-based lifestyle intervention compared to a standardized education and physician advice counseling session on blood presssure and CVD biomarkers in patients with RH after 4 months of treatment, and will determine whether lifestyle changes can be maintained for a year. PMID:26542509

  13. Under severe citrus canker and HLB (Huanglongbing) pressure, Triumph and Jackson perform better than Flame and Marsh grapefruit

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Huanglongbing (HLB) and Citrus Canker (CC) threaten the viability of Florida grapefruit production. Triumph (T), reportedly a grapefruit/sweet orange hybrid, is similar to seedy white grapefruit with earlier maturity and lower bitterness. Jackson (J) is a low-seeded budsport of Triumph. Tree health ...

  14. "Triumph of the Will": A Limit Case for Effective-Historical Consciousness?

    ERIC Educational Resources Information Center

    Schwartzman, Roy

    A film presented as factual may permit critical responses that question its purported factual objectivity and political neutrality. In class, Hans-Georg Gadamer's concept of effective-historical consciousness can be used to evaluate the allegedly propagandistic messages in Leni Riefenstahl's "Triumph of the Will." Analysis of this 1934…

  15. 77 FR 2278 - Intent To Grant an Exclusive License for a U.S. Army Owned Invention to Triumph Actuation Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Department of the Army Intent To Grant an Exclusive License for a U.S. Army Owned Invention to Triumph... to Triumph Actuation Systems--Connecticut, LLC, of Bloomfield, CT in U.S. patent 7,228,779, issued... Primer Feed Mechanism''. Any license granted shall comply with 35 U.S.C. 209 and 37 CFR Part 404....

  16. Tapered triumph

    NASA Astrophysics Data System (ADS)

    2009-01-01

    German company M2K Laser was the first in the world to successfully commercialize tapered diode lasers, and is currently the only one making gallium antimonide devices. The company's managing director speaks to Nadya Anscombe about its strategy and future.

  17. Case Studies in Context: A Review of Triumphs in Early Autism Treatment, edited by Ennio Cipani

    PubMed Central

    Ingvarsson, Einar T

    2009-01-01

    Triumphs in Early Autism Treatment, edited by Ennio Cipani, describes seven “best-outcome” case studies of early and intensive behavioral intervention (EIBI) for children with autism, demonstrating the challenges that occur during various stages of treatment. The children whose stories are told in the book achieved normal functioning and lost their diagnosis of autism. Although outcomes are not this dramatic for all children, the book nevertheless serves a useful purpose in drawing attention to the favorable outcomes that some children may reach through EIBI. The book also contains accessible chapters describing the history of behavior analytic interventions for autism, and an overview of the published outcome research that forms part of the evidence base for EIBI.

  18. Lower urinary tract symptoms suggestive of benign prostatic obstruction--Triumph: design and implementation.

    PubMed

    Chapple, C R

    2001-01-01

    Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) are likely to become an increasing burden for health care budgets in the future due to the high prevalence of this condition in the elderly and the ageing of the population. Data on the cost-effectiveness of the available treatment options in order to promote rational management will therefore be crucial. As this information is currently largely lacking, the European Association of Urology (EAU) has endorsed the formation of a Pan-European Expert Panel that has developed the Triumph (TransEuropean Research Into the Use of Management Policies for LUTS suggestive of BPH in Primary Healthcare) project. The Triumph project will evaluate how LUTS suggestive of BPO is currently managed in real life practice in initially 6 European countries (France, Germany, Italy, Poland, Spain and the UK) and how this condition progresses over time in relation to an initial treatment choice. In other words, how many patients remain on their initial therapy, how many switch to another therapy (including surgery) and within which time frame and how many develop serious complications related to BPO such as acute urinary retention. The clinical data will be retrieved from continuous analysis of large computer-based patient files such as the General Practice Research Database (GPRD) in the UK and the Integrated Primary Care Information (IPCI) database in The Netherlands. Furthermore, a cross-sectional, observational survey will gather similar data in a prospective fashion for at least 1 year from approximately 13,000 patients managed by more than 1,000 primary care physicians in all 6 countries. Both newly diagnosed (around 7,500) and existing (around 5,500) LUTS patients will be enrolled. For the existing patients in whom the diagnosis was made in the past (from January 1997 onwards), the relevant retrospective data (up to 3.5 years) on disease progression will also be collected. Finally, the costs

  19. The response to the trench diseases in World War I: a triumph of public health science.

    PubMed

    Atenstaedt, R L

    2007-08-01

    The recent 90-year anniversary of the Battle of the Somme presents an opportunity to examine the public health response to the trench diseases, new conditions which arose in the trenches of World War I. Throughout history, there have been two views of epidemic disease: the configurationist and contagionist perspectives. Most doctors responding to the trench diseases, 'contingent-contagionists', combined these two conceptions of disease. Because of the difficulty of finding a causative organism and the absence of effective treatment, the majority view became that these conditions were a product of the trench environment. Configurationism, with its emphasis on environmental and social determinants, seemed to provide the most obvious approaches for tackling the trench diseases. The diseases were effectively controlled using the tools of public health science: sanitary discipline and a battery of measures, such as improving trench construction, improving the diet, providing protective kit, regular bathing and treating lice infestation. The response demonstrates the triumph of public health science over new medical technologies. It also illustrates the importance of considering all the many determinants of health and of close surveillance, discipline and partnership working to counter ill-health. Although technology, training, doctrine and health beliefs change over time, the interaction between disease and environment remains the core challenge to public health practitioners.

  20. "I Was Proud of Myself That I Didn't Give up and I Did It": Experiences of Pride and Triumph in Learning Science

    ERIC Educational Resources Information Center

    Bellocchi, Alberto; Ritchie, Stephen M.

    2015-01-01

    The role that specific emotions, such as pride and triumph, play during instruction in science education is an under researched field of study. Emotions are recognized as central to learning yet little is known about the way in which they are produced in naturalistic settings, how emotions relate to classroom learning during interactions, and what…

  1. Lower urinary tract symptoms suggestive of benign prostatic obstruction--Triumph: the role of general practice databases.

    PubMed

    Logie, J W; Clifford, G M; Farmer, R D; Meesen, B P

    2001-01-01

    The Triumph project aims to document the current management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) in general practice and to assess the effectiveness of the initial treatment options used. The first phase of the project will consider existing data sources in primary care. A patient's medical record will contain most, if not all, clinically relevant information, and databases combining the records from a network of computerised general practices can provide longitudinal data for complete populations, linking prescribing records to clinical information on disease progression and outcomes for individual patients. Database research can provide rapid information and offers the ability to conduct studies on a scale that would previously have been prohibited by both time and expense. Within the Triumph project, the THALES, General Practice Research Database (GPRD) and Integrated Primary Care Information (IPCI) databases are, or will be, used to examine the current management of LUTS/BPH in France, the UK and the Netherlands respectively. Preliminary results from the UK General Practice Research Database (GPRD) showed that LUTS/BPH incidence increased linearly from the ages of 45 to 85 years (r(2) = 0.992) and prevalence increased from 3.5% to 35% for men in their late 40s and 80s respectively. With treatment failure defined as a change to another medical therapy, catheterisation or prostatic surgery, and accounting for age and year variation, patients receiving the older alpha(1)-blockers (indoramin and prazosin) appeared to fail significantly earlier than those receiving finasteride. There was no significant difference between finasteride and the newer alpha(1)-blockers (tamsulosin, alfuzosin, terazosin and doxazosin). Patterns of changes between products from the THALES database in France were broadly similar to those seen in the UK.

  2. The triumph and decline of the "squares": Grumman Aerospace engineers and production workers in the Apollo era, 1957--1973

    NASA Astrophysics Data System (ADS)

    Onkst, David Hugh

    This dissertation is a social, cultural, and economic history of the men and women of the Grumman Aerospace Company of Bethpage, New York from 1957 through 1973. These "Grummanites" were the engineers and production workers who designed and built the Apollo Lunar Modules that allowed humans to land on the Moon. This study provides unique insights into the impact that the Apollo Program---a large state-initiated and -supported program---had on those "squares," people whom many contemporaries saw as a vital part of mainstream 1960s American society. By the beginning of the Space Age in 1957, Grumman, Long Island's single largest employer, had firmly established a workplace culture of paternalism that Grummanites largely embraced. Company officials believed strongly in worker retention and had established a policy of providing every sort of benefit their employees seemingly desired, including a highly personal and participatory form of management. Many Grummanites had joined the firm during the early years of the Apollo Program because they believed in the promise of permanent employment on exciting projects that would explore the endless frontier of space. But, as many of these mainly self-reliant, individualistic "squares" would bitterly discover, their dedication to Grumman did little to secure their livelihoods during the aerospace industry's early 1970s downsizing; their individual successes were too largely tied to federal spending and declined when Americans grew disenchanted with space exploration. This dissertation demonstrates how the cultural bond of paternalism between aerospace workers and their company unraveled in the 1960s, and then ended in the early 1970s, because of forces within the company, the economy, and the American state. The word "triumph" in this study's title not only applies to Grummanites' triumphs with the Lunar Modules, but also their individual socioeconomic victories. The term "decline" refers to the early 1970s downsizing of more

  3. Utility of a Genetic Risk Score to Predict Recurrent Cardiovascular Events 1 Year After an Acute Coronary Syndrome: A Pooled Analysis of the RISCA, PRAXY, and TRIUMPH Cohorts

    PubMed Central

    Labos, Christopher; Martinez, Sara C.; Leo Wang, Rui Hao; Lenzini, Petra A.; Pilote, Louise; Bogaty, Peter; Brophy, James M.; Engert, James C.; Cresci, Sharon; Thanassoulis, George

    2015-01-01

    Background Limited evidence exists regarding the utility of genetic risk scores (GRS) in predicting recurrent cardiovascular events after acute coronary syndrome (ACS). We sought to determine whether a GRS would predict early recurrent cardiovascular events within 1 year of ACS. Methods & Results Participants admitted with acute coronary syndromes from the RISCA, PRAXY, and TRIUMPH cohorts, were genotyped for 30 single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) or myocardial infarction (MI) in prior genome wide association studies. A 30 SNP CAD/MI GRS was constructed. The primary endpoint was defined as all-cause mortality, recurrent ACS or cardiac re-hospitalization within 1 year of ACS admission. Results across all cohorts for the 30 SNP CAD/MI GRS were pooled using a random-effects model. There were 1040 patients from the RISCA cohort, 691 patients from the PRAXY cohort, and 1772 patients from the TRIUMPH cohort included in the analysis and 389 occurrences of the primary endpoint of recurrent events at 1-year post-ACS. In unadjusted and fully adjusted analyses, a 30 SNP GRS was not significantly associated with recurrent events (HR per allele 0.97 (95%CI 0.91–1.03) for RISCA, HR 0.99 (95%CI 0.93–1.05) for PRAXY, 0.98 (95%CI 0.94–1.02) for TRIUMPH, and 0.98 (95%CI 0.95–1.01) for the pooled analysis). Addition of this GRS to the GRACE risk model did not significantly improve risk prediction. Conclusion The 30 MI SNP GRS was not associated with recurrent events 1-year post ACS in pooled analyses across cohorts and did not improve risk discrimination or reclassification indices. Our results suggest that the genetic etiology of early events post-ACS may differ from later events. PMID:26232166

  4. Reason, Purpose & Triumph

    ERIC Educational Resources Information Center

    Johnson, Lincoln

    2010-01-01

    In this article, part of the Why I Teach essay series, the author shares how he developed his love for teaching and the failures and successes he experienced as a teacher. He used to hate teachers but everything changed when he entered college. He took general education classes and began to notice the difference between the great teachers and the…

  5. Triumph in Tough Times

    ERIC Educational Resources Information Center

    Ponder, Anne

    2009-01-01

    The downturn in the economy of the author's state, North Carolina, so far is less severe than that of much of the rest of the nation, due to their diversified economy, financial discipline, constitutional mandate for a balanced budget, "rainy day" fund, and many years of consistent investment in higher education. In the University of…

  6. Protocol for a multicentre study to assess feasibility, acceptability, effectiveness and direct costs of TRIumPH (Treatment and Recovery In PsycHosis): integrated care pathway for psychosis

    PubMed Central

    Rathod, Shanaya; Garner, Christie; Griffiths, Alison; Dimitrov, Borislav D; Newman-Taylor, Katherine; Woodfine, Chris; Hansen, Lars; Tabraham, Paul; Ward, Karen; Asher, Carolyn; Phiri, Peter; Naeem, Farooq; North, Pippa; Munshi, Tariq; Kingdon, David

    2016-01-01

    Introduction Duration of untreated psychosis (time between the onset of symptoms and start of treatment) is considered the strongest predictor of symptom severity and outcome. Integrated care pathways that prescribe timeframes around access and interventions can potentially improve quality of care. Methods and analysis A multicentre mixed methods study to assess feasibility, acceptability, effectiveness and analysis of direct costs of an integrated care pathway for psychosis. A pragmatic, non-randomised, controlled trial design is used to compare the impact of Treatment and Recovery In PsycHosis (TRIumPH; Intervention) by comparison between NHS organisations that adopt TRIumPH and those that continue with care as usual (Control). Quantitative and qualitative methods will be used. We will use routinely collected quantitative data and study-specific questionnaires and focus groups to compare service user outcomes, satisfaction and adherence to intervention between sites that adopt TRIumPH versus sites that continue with usual care pathways. Setting 4 UK Mental health organisations. Two will implement TRIumPH whereas two will continue care as usual. Participants Staff, carers, individuals accepted to early intervention in psychosis teams in participating organisations for the study period. Intervention TRIumPH—Integrated Care Pathway for psychosis that has a holistic approach and prescribes time frames against interventions; developed using intelligence from data; co-produced with patients, carers, clinicians and other stakeholders. Outcomes Feasibility will be assessed through adherence to the process measures. Satisfaction and acceptability will be assessed using questionnaires and focus groups. Effectiveness will be assessed through data collection and evaluation of patient outcomes, including clinical, functional and recovery outcomes, physical health, acute care use. Outcome measures will be assessed at baseline, 12 and 24 months to measure whether there is

  7. News Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

  8. [The triumph of China China

    PubMed

    Vannozzi, F.

    2000-01-01

    Malaria and its various remedies were frequently debated by Italian scientists in the 17th and 18th centuries. Physicians of the period discussed the probable origin of the disease, making use of the humoral theory, whilst upholding the efficacy of a new remedy, the bark of the cinchona tree. Knowledge of malaria, the various pathogenetic theories and some quite bizarre therapeutic attempts are amply documented in the medical literature of the age.

  9. Triumph of the Voyager mission

    USGS Publications Warehouse

    Kerr, R. A.

    1989-01-01

    It had been a long, productive trip. Launched in 1977, the two Voyager spacecraft had visited three giant planets, a dozen major Moons, three ring systems with thousands of rings composed of a myriad of tiny Moonlets. The spacecraft had returned 5 trillion bits of data and over 100,000 photographs. The last encounter in our Solar System by Voyager 2 with Neptune was to be a spectacular finale to the 12-year drama. 

  10. Ethnic minority psychology: struggles and triumphs.

    PubMed

    Sue, Stanley

    2009-10-01

    This article focuses on my interpretation of the history of ethnic minority psychology, using as a base the presentations of the contributing authors to this special issue of Cultural Diversity and Ethnic Minority Psychology. Because each contributing author has focused on a particular ethnic group or a particular aspect of history, my goal is to focus on 3 common issues and problems. First, what are the themes and issues that confronted African Americans, American Indians and Alaska Natives, Asian Americans, and Latinos? Second, what were characteristics of the ethnic leaders on whose shoulders we now stand? Third, what kinds of relationships existed between members of different ethnic minority groups?

  11. Shared Struggles, Shared Triumphs: Watching Writers Write.

    ERIC Educational Resources Information Center

    Greenberg, Mark

    When teachers base classroom discussion of literature, particularly poetry, on the authors' manuscripts, notebooks, and letters, they allow students to watch writers write and to appreciate the craft involved in creative writing. Watching the writer at work--examining the drafts and correspondence for such poems as Blake's "London" or Keats'"To…

  12. Forgiver triumphs in alternating Prisoner's Dilemma.

    PubMed

    Zagorsky, Benjamin M; Reiter, Johannes G; Chatterjee, Krishnendu; Nowak, Martin A

    2013-01-01

    Cooperative behavior, where one individual incurs a cost to help another, is a wide spread phenomenon. Here we study direct reciprocity in the context of the alternating Prisoner's Dilemma. We consider all strategies that can be implemented by one and two-state automata. We calculate the payoff matrix of all pairwise encounters in the presence of noise. We explore deterministic selection dynamics with and without mutation. Using different error rates and payoff values, we observe convergence to a small number of distinct equilibria. Two of them are uncooperative strict Nash equilibria representing always-defect (ALLD) and Grim. The third equilibrium is mixed and represents a cooperative alliance of several strategies, dominated by a strategy which we call Forgiver. Forgiver cooperates whenever the opponent has cooperated; it defects once when the opponent has defected, but subsequently Forgiver attempts to re-establish cooperation even if the opponent has defected again. Forgiver is not an evolutionarily stable strategy, but the alliance, which it rules, is asymptotically stable. For a wide range of parameter values the most commonly observed outcome is convergence to the mixed equilibrium, dominated by Forgiver. Our results show that although forgiving might incur a short-term loss it can lead to a long-term gain. Forgiveness facilitates stable cooperation in the presence of exploitation and noise.

  13. WHO celebrates triumph over river blindness.

    PubMed

    Ciment, J

    1999-10-23

    This article reports the success of WHO in eliminating onchocerciasis or river blindness in most of West Africa. The onchocerciasis control program was able to save 100,000 people at immediate risk of contracting the disease and prevented the infection of about 12 million children. About 1.25 million onchocercal infections have been resolved by the program. Moreover, removal of the threat of the disease has allowed people to farm 25 million hectares of fertile land capable of feeding 17 million people annually. The land was previously abandoned due to black fly infestations, the transmission vector of the disease. The control program, which was started 25 years ago, had successfully eliminated the disease after a partnership between the UN agency and Merck, the company that developed ivermectin. Ivermectin is the first drug against river blindness that could be dispensed widely without fear of serious side effects.

  14. A television triumph about death and dying.

    PubMed

    Towers, Bernard

    1980-06-01

    Towers reviews Joan Robinson: One Woman's Story, an American documentary film about a terminal cancer patient that was first broadcast by the Public Broadcasting Service on 21 January 1980. The film was made at the instigation of Robinson, a writer and editor, and covers the last twenty-two months of her life from the diagnosis of incurable ovarian cancer to her graveside funeral service. Towers praises the film-makers for their empathetic and sensitive handling of a difficult subject, and recommends that the film be made available for teaching purposes.

  15. Trials and Triumphs of Expanded Extension Programs.

    ERIC Educational Resources Information Center

    Leavengood, Scott; Love, Bob

    1998-01-01

    Oregon extension faced challenges in presenting programs in the wood products industry. Several traditional tactics, revised to suit a new audience, have proved successful: personal coaching, building partnerships, and providing a high level of service. Newer methods, such as database marketing and distance learning, are also proving to be…

  16. Turmoil and triumph: My years as secretary of state

    SciTech Connect

    Schultz, G.P.

    1993-12-31

    The Reagan administration, or members of it, may have believed their own propaganda about the United States (U.S.) military weakness in 1980 and 1981, but the Soviet leaders never did. Nor did they ever doubt or challenge U.S. deterrence or determination to repel agression against the U.S. or its allies. What was new was a belated recognition by Moscow`s leaders that the Marxist-Lennist world view they had held for 70 years did not accord with reality, and that their combined efforts to apply that pattern for internal development did not accord with the real needs of society. It was a remarkable turn of policy in Reagan`s second term that led to five summit meetings, as many as in the preceding three presidencies, and One-third of all the postwar, Cold War summits. One of the most interesting and valuable contributions of this book is the picture of the inner workings of the Reagan administration, as seen by the secretary of state.

  17. SLE or hypothyroidism: who can triumph in cardiac tamponade?

    PubMed

    Chaudhari, Sameer Sadashiv; Wankhedkar, Kashmira Pramod; Mushiyev, Savi

    2015-03-06

    A 36-year-old Hispanic woman with a history of systemic lupus erythaematosus (SLE) in remission presented with progressive dyspnoea, bilateral leg swelling and increasing fatigue with rapid weight gain over the past few months. Her physical examination showed mildly tender thyromegaly and pericardial rub. Investigations showed new onset marked hypothyroidism as well as an active lupus serology with echocardiogram confirming severe pericardial effusion and a tamponade phenomenon. Urgent pericardiocentesis relieved her acute symptoms, and prompt treatment with thyroxine replacement and immunosuppression for lupus disease was initiated. Pericardial fluid analysis remained negative for any malignancy and/or infection/s. The patient had a gradual and consistent improvement with this treatment. She was discharged and appeared to be clinically stable at subsequent follow-up visits. However, the case remained a diagnostic dilemma over whether the tamponade was being driven by hypothyroidism versus lupus, leaving us with an opportunity to explore further.

  18. Turmoil, Transition - Triumph? The Democratic Revolution in the Philippines

    DTIC Science & Technology

    1986-06-01

    opposition. (>ver the last five years, however, he had become more and more outspoken in his criticism. Under his leadership the so-called " Jesuit Mafia" in...Corporation, and a great Indonesia scholar. * Drew Pearson, the producer of the Philippine documentary that Stan Karnow is making. * Edith Coliver, ex- of...revolution started. "But I don’t have .a habit", he explained to Father Bernas. "We’ll look for a Jesuit habit in the house", replied Bernas. The

  19. Is the eradication of tuberculosis 'yesterday's ambition' or 'tomorrow's triumph'?

    PubMed

    Zumla, Alimuddin; Grange, John M

    2010-10-01

    Tuberculosis (TB) remains a serious infectious disease continuing to cause around 1.8 million deaths annually. The great paradox is that despite the availability of effective treatment for the past 60 years, it continues to spread relentlessly, particularly in sub-Saharan Africa due to the fuelling effect of the HIV/AIDS epidemic. It is no longer a medical epidemic, but an epidemic of injustice. Increased political and financial investment by the industrially developed nations, as well as sustained political will in the affected countries, is required to bring TB under control. It is imperative that the control should be linked to that of HIV which is also closely associated with poverty, poor housing and malnutrition. The historical, social, philosophical and political perspectives that may have influenced the failure of TB control are discussed. Once again, therefore, the question is raised--can TB be brought under control?

  20. The Plus 50 Population in Higher Education: Challenges and Triumphs

    ERIC Educational Resources Information Center

    Barr, Jason

    2016-01-01

    As the economy in the United States continues to emerge from a recession and as jobs become more technologically advanced rendering other jobs obsolete, more and more Americans over the age of 50 are now attending college for a variety of reasons. Around 77% of the so-called Plus 50 students were enrolled in two-year public institutions. Other…

  1. The World Medical Association: can hope triumph over experience?

    PubMed Central

    Richards, T.

    1994-01-01

    The World Medical Association was set up in 1947 in the wake of outrage about war crimes committed by doctors in Hitler's Germany. For nearly 50 years it has lurched from one controversy to another, arguing within itself about its funding, its voting system, and the representativeness and political affiliation of some of its member medical associations. The BMA withdrew from the association in 1984, supporting a breakaway "Toronto" group including Canada, the Scandinavian countries, the Netherlands, Ireland, and Jamaica. All but Britain and Jamaica have now rejoined and membership is growing, but the association is still struggling to gain credibility and clout. After 20 years of part time stewardship the recent appointment of a new full time secretary general has fuelled expectations that internal reforms will be implemented, and the WMA's standing and profile improved. PMID:8111265

  2. The Middle School High Five: Strategies Can Triumph

    ERIC Educational Resources Information Center

    Goodman, Amy

    2005-01-01

    A literacy support teacher leads a district-wide initiative to organize content-area teachers in an effort to help their students become better readers by offering instruction and practice in five reading strategies across the curriculum. At the end of the 10-week program, teachers felt that students' comprehension had improved, and many felt some…

  3. Project Physics Teacher Guide 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Teaching procedures of Project Physics Unit 3 are presented to help teachers make effective use of learning materials. Unit contents are discussed in connection with teaching aid perspective, multi-media schedules, schedule blocks, and resource charts. Brief analyses are made for transparencies, 16mm films, and reader articles. Included is…

  4. The Rise and Triumph of the White House Photo Opportunity.

    ERIC Educational Resources Information Center

    Streitmatter, Rodger

    1988-01-01

    Measures the news coverage that has resulted from photo opportunities staged by United States presidents who have served since 1960. Finds that photo coverage of presidents in four major newspapers rose sixfold since 1960. (RS)

  5. Triumph of Technology Over Geography - Unlocking the Siberian Maritime Icebox,

    DTIC Science & Technology

    1987-05-22

    transportation system, one is struck by their long term commitment to ensure that all the pieces fit and function together into a national transport service...1990,1. To counterbalance this strategic presence, substantial U.S. and Canadian government investment %will undoubtedly be necessary. Such a long term ...commitment is justified by both national security arguments a- well as future, long term economic development rationale. The US and Canada need to

  6. The identification of Josef Mengele. A triumph of international cooperation.

    PubMed

    Eckert, W G; Teixeira, W R

    1985-09-01

    In recent weeks, world attention has been focused on the identification of skeletal remains suspected of being those of the most widely sought Nazi war criminal still at large--Josef Mengele. Several important turns in the investigation of his whereabouts led to a small city south of São Paulo, where he had been living until 1979. Mengele was reported to have drowned and to have been buried in a country cemetery near his last residence. The initial processing of the remains was done at the Medicolegal Institute of São Paulo by police officials in consultation with anthropologists and dentists as well as Dr. Wilmes Teixeira of Mogi das Cruzes, a suburb of São Paulo. Dr. Teixeira coordinated the team of authorized international forensic experts officially representing the governments of West Germany and the United States, as well as the Simon Wiesenthal Center of Los Angeles, who joined Brazilian scientists in completing identification. The success of the investigation was due to complete cooperation among members of the team, resulting in verification, within a reasonable scientific certainty, that these were the remains of Josef Mengele.

  7. Listening, talking triumph in promoting effective public involvement

    SciTech Connect

    Forrest, C.J.; Michaud, G.R.

    1995-07-01

    When added to situations involving formal Superfund cleanups, RCRA permitting and other environmental issues, it is clear that understanding how to handle community concerns is rapidly becoming a necessity for many businesses. The terms public involvement, public participation and community relations all embody the same concept--establishing a dialogue with members of the public who are affected by environmental permitting, a contaminated site or other environmental issues. The goal of the dialogue is to promote public understanding about a project or issue, and ensure that citizens` concerns are considered and thoroughly addressed. Public concerns often are magnified by lack of information, misinformation or false information about an environmental issue. Failing to acknowledge concerns and provide appropriate information can lead to community resistance. In their extreme forms, such communications failures have slowed or blocked the permitting process, and even halted removal of hazardous wastes from residential and nonresidential areas. Community relations requirements under the Comprehensive Environmental Response, Compensation and Liability Act, and public participation requirements under the Resource Conservation and Recovery Act are intended to promote positive dialogue. In both cases, core activities and their timing are set by regulation.

  8. Project Physics Reader 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    As a supplement to Project Physics Unit 3, a collection of articles is presented in this reader for student browsing. Four excerpts are given under the following headings: On the kinetic theory of gases, Maxwell's Demon, Introduction to Waves, and Scientific Cranks. Five articles are included in terms of energy, barometers, randomness, fiddle…

  9. Triumphs Show: Taking Students outside the Classroom "inside" the Classroom

    ERIC Educational Resources Information Center

    Osowiecki, Maria; Francis, Robin

    2014-01-01

    Year 9 think they know a lot about the First World War. After all, they read Michael Morpurgo's novel Private Peaceful in their English lessons all the way back in Year 7, they have seen Blackadder so many times they can recite it, and in the centenary year of the war's outbreak, they can hardly avoid it on television. But their view of the war…

  10. Integrating the Study of the Holocaust: One School's Triumph

    ERIC Educational Resources Information Center

    Ruder, Robert

    2005-01-01

    Integrating the study of the Holocaust into the middle school curriculum is a formidable challenge. This article describes the approach taken by Whitwell Middle School in Tennessee: When teachers found that students were having a difficult time comprehending the number of Jews and others killed by the Nazis, they decided to have the students…

  11. Saving the Dust Bowl: "Big Hugh" Bennett's Triumph over Tragedy

    ERIC Educational Resources Information Center

    Smith, Rebecca

    2007-01-01

    In the 1930s, years of injudicious cultivation had devastated 100 million acres of Kansas, Oklahoma, Texas, Colorado, and New Mexico. This was the Dust Bowl, and it exposed a problem that had silently plagued American agriculture for centuries--soil erosion. Farmers, scientists, and the government alike considered it trivial until Hugh Hammond…

  12. Trial, Error, Triumph: A College Rethinks Its Core Curriculum

    ERIC Educational Resources Information Center

    Jordan-Fleming, Mary Kay; Klabunde, Michael; Zane, Cynthia

    2005-01-01

    Promoting student learning can be difficult, even at a liberal arts and sciences college where faculty members are passionate about it. The authors have experienced these challenges at the College of Mount St. Joseph in the last five years as they have moved collegewide efforts more intentionally toward facilitation of learning. The College of…

  13. Evidence-based practice: triumph of style over substance?

    PubMed

    Booth, Andrew

    2011-09-01

    This feature examines the success of evidence-based practice (EBP) and the associated Cochrane Collaboration. It seeks to identify critical success factors associated with the way that both initiatives have been marketed. The simplicity of the original message used by each initiative allowed for subsequent assimilation of nuances and variants. Two implications for health librarians are highlighted; recognition that EBP is simply the embodiment of one world view and that many others may make a useful contribution and the need to craft a simple message capturing the unique selling points of the profession. To create a unique contribution health librarians require a detailed picture from market research of user information needs.

  14. Challenges and Triumphs to Genomics-Based Natural Product Discovery

    PubMed Central

    Jensen, Paul R.; Chavarria, Krystle L.; Fenical, William; Moore, Bradley S.; Ziemert, Nadine

    2013-01-01

    Genome sequencing is rapidly changing the field of natural products research by providing opportunities to assess the biosynthetic potential of strains prior to chemical analysis or biological testing. Ready access to sequence data is driving the development of new bioinformatic tools and methods to identify the products of silent or cryptic pathways. While genome mining has fast become a useful approach to natural product discovery, it has also become clear that identifying pathways of interest is much easier than finding the associated products. This has led to bottlenecks in the discovery process that must be overcome for the potential of genomics-based natural product discovery to be fully realized. In this perspective, we address some of these challenges in the context of our work with the marine actinomycete genus Salinispora, which is proving to be a useful model with which to apply genome mining as an approach to natural product discovery. PMID:24104399

  15. Profitable failure: antidepressant drugs and the triumph of flawed experiments.

    PubMed

    McGoey, Linsey

    2010-01-01

    Drawing on an analysis of Irving Kirsch and colleagues' controversial 2008 article in "PLoS [Public Library of Science] Magazine" on the efficacy of SSRI antidepressant drugs such as Prozac, I examine flaws within the methodologies of randomized controlled trials (RCTs) that have made it difficult for regulators, clinicians and patients to determine the therapeutic value of this class of drug. I then argue, drawing analogies to work by Pierre Bourdieu and Michael Power, that it is the very limitations of RCTs -- their inadequacies in producing reliable evidence of clinical effects -- that help to strengthen assumptions of their superiority as methodological tools. Finally, I suggest that the case of RCTs helps to explore the question of why failure is often useful in consolidating the authority of those who have presided over that failure, and why systems widely recognized to be ineffective tend to assume greater authority at the very moment when people speak of their malfunction.

  16. Level 5 leadership. The triumph of humility and fierce resolve.

    PubMed

    Collins, J

    2001-01-01

    Boards of directors typically believe that transforming a company from merely good to truly great requires a larger-than-life personality--an egocentric chief to lead the corporate charge. Think "Chainsaw" Al Dunlap or Lee Iacocca. In fact, that's not the case, says author and leadership expert Jim Collins. The essential ingredient for taking a company to greatness is having a "Level 5" leader at the helm--an executive in whom extreme personal humility blends paradoxically with intense professional will. Collins paints a compelling and counter-intuitive portrait of the skills and personality traits necessary for effective leadership. He identifies the characteristics common to Level 5 leaders: humility, will, ferocious resolve, and the tendency to give credit to others while assigning blame to themselves. Collins fleshes out his Level 5 theory by telling colorful tales about 11 such leaders from recent business history. He contrasts the turnaround successes of outwardly humble, even shy, executives like Gillette's Colman M. Mockler and Kimberly-Clark's Darwin E. Smith with those of larger-than-life business leaders like Dunlap and Iacocca, who courted personal celebrity. The jury is still out on how to cultivate Level 5 leaders and whether it's even possible to do so, Collins admits. Some leaders have the Level 5 seed within; some don't. But Collins suggests using the findings from his research to strive for Level 5--for instance, getting the right people on board and creating a culture of discipline. "Our own lives and all that we touch will be better for the effort," he concludes.

  17. Resisting Reading Mandates: How To Triumph with the Truth.

    ERIC Educational Resources Information Center

    Garan, Elaine M.

    Teachers today are in a stranglehold as a glut of mandates and standards restrict their ability to make decisions in their own classrooms. In many schools, scripted, regimented commercial programs further erode their power to view their students as individuals with unique talents and needs. Even the words they use "to teach" are no…

  18. Project Physics Text 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Mechanical theories are presented in this unit of the Project Physics text for senior high students. Collisions, Newton's laws, isolated systems, and Leibniz' concept are discussed, leading to conservation of mass and momentum. Energy conservation is analyzed in terms of mechanical energy, heat energy, steam engines, Watt's engine, Joule's…

  19. The World Medical Association: can hope triumph over experience?

    PubMed

    Richards, T

    1994-01-22

    The World Medical Association was set up in 1947 in the wake of outrage about war crimes committed by doctors in Hitler's Germany. For nearly 50 years it has lurched from one controversy to another, arguing within itself about its funding, its voting system, and the representativeness and political affiliation of some of its member medical associations. The BMA withdrew from the association in 1984, supporting a breakaway "Toronto" group including Canada, the Scandinavian countries, the Netherlands, Ireland, and Jamaica. All but Britain and Jamaica have now rejoined and membership is growing, but the association is still struggling to gain credibility and clout. After 20 years of part time stewardship the recent appointment of a new full time secretary general has fuelled expectations that internal reforms will be implemented, and the WMA's standing and profile improved.

  20. SLE or hypothyroidism: who can triumph in cardiac tamponade?

    PubMed Central

    Chaudhari, Sameer Sadashiv; Wankhedkar, Kashmira Pramod; Mushiyev, Savi

    2015-01-01

    A 36-year-old Hispanic woman with a history of systemic lupus erythaematosus (SLE) in remission presented with progressive dyspnoea, bilateral leg swelling and increasing fatigue with rapid weight gain over the past few months. Her physical examination showed mildly tender thyromegaly and pericardial rub. Investigations showed new onset marked hypothyroidism as well as an active lupus serology with echocardiogram confirming severe pericardial effusion and a tamponade phenomenon. Urgent pericardiocentesis relieved her acute symptoms, and prompt treatment with thyroxine replacement and immunosuppression for lupus disease was initiated. Pericardial fluid analysis remained negative for any malignancy and/or infection/s. The patient had a gradual and consistent improvement with this treatment. She was discharged and appeared to be clinically stable at subsequent follow-up visits. However, the case remained a diagnostic dilemma over whether the tamponade was being driven by hypothyroidism versus lupus, leaving us with an opportunity to explore further. PMID:25750217

  1. American style or Turkish chair: the triumph of bodily comfort.

    PubMed

    Çevik, Gülen

    2010-01-01

    This article investigates the reciprocal influence of Ottoman Turkish and American interiors in the development of seating furniture. Seating furniture is unique because it involves a direct and physical interaction between the piece of furniture and the body, while at the same time it is part of a public space where social interactions occur. I will argue that the interactions between the Ottoman Turks and Americans are reflected in the way these traditions modified their seating furniture as they sought to mediate cultural, political and social differences between them. The concept of bodily comfort will serve as a common thread in understanding the origin of the expression "American style" (Amerikan stili or Amerikan tarzı) in modern Turkish language, the "Turkish chairs" in Victorian America in the late nineteenth century and the English language use of words such as sofa, ottoman and divan.

  2. Project Physics Tests 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Test items relating to Project Physics Unit 3 are presented in this booklet. Included are 70 multiple-choice and 20 problem-and-essay questions. Concepts of mechanics are examined on energy, momentum, kinetic theory of gases, pulse analyses, "heat death," water waves, power, conservation laws, normal distribution, thermodynamic laws, and…

  3. Ear candles: a triumph of ignorance over science.

    PubMed

    Ernst, E

    2004-01-01

    Ear candles are hollow tubes coated in wax which are inserted into patients' ears and then lit at the far end. The procedure is used as a complementary therapy for a wide range of conditions. A critical assessment of the evidence shows that its mode of action is implausible and demonstrably wrong. There are no data to suggest that it is effective for any condition. Furthermore, ear candles have been associated with ear injuries. The inescapable conclusion is that ear candles do more harm than good. Their use should be discouraged.

  4. From Tragedy to Triumph - Rebuilding Green Buildings after Disaster

    SciTech Connect

    2009-10-01

    Fact sheet offering practical information about building energy efficient buildings and using renewable energy. Includes a checklist and resources. Highlights successful projects in Greensburg, Kansas.

  5. Project Physics Handbook 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Ten experiments and 27 activities are presented in this handbook. The experiments are related to collisions, energy conservation, speed measurements, thermometry, calorimetry, gas properties, wave motions, and acoustic problems. The activities are concerned with stroboscopic photographs in collision, elastic impact, mass conservation, exchange of…

  6. English-Only Triumphs, but the Costs are High.

    ERIC Educational Resources Information Center

    Portes, Alejandro

    2002-01-01

    Explores the issue of English-only versus bilingual education by focusing on whether complete language assimilation is desirable for immigrant children and their families. Discusses the benefits of bilingualism, such as students exhibiting greater self-esteem, the benefits for immigrant families, and advantages for the labor market. Highlights the…

  7. Vaccinations: A public health triumph and a public relations tragedy.

    PubMed

    Jacobson, Robert M

    2012-08-01

    Routine vaccination has been hailed as one of the top public health achievements of the last century. However, despite the reduced number of cases of and deaths from vaccine-preventable diseases such as pertussis and measles, outbreaks continue to occur as more parents fail to adequately vaccinate their children because of misinformation about immunizations. This article describes the challenges of making sure all children in the United States are fully immunized and what physicians need to know to effectively work with parents who may be hesitant to vaccinate their children.

  8. In Their Own Words: Researchers' Stories of Challenges and Triumphs in Data Management and Sharing

    NASA Astrophysics Data System (ADS)

    Rebich Hespanha, S.; Menz, S. M.

    2013-12-01

    As data-intensive computational analysis has become more pervasive in the Earth and environmental sciences, the need for adopting new ways to organize, manage, and preserve data has become increasingly apparent. As more and more data are collected, the benefits (or potential benefits) of sharing and re-using these data become ever more obvious. Technically-inclined disciplinary scientists, informaticians, and advocates of open science have already begun working together to develop tools and best practices that help to pave the way for a new era in data management and sharing. In spite of these innovative (and mostly technical) advances, researchers who wish to effectively manage and re-use data, or who are obligated by funding requirements to do so, still face many challenges. Here we report on the DataONE Data Stories project, which is focused on collecting researchers' stories about conflicts and successes that they have encountered when managing data and making efforts to share or re-use data. We highlight the types of events and situations that commonly lead to conflict or obstacles for the researchers we have interviewed. We emphasize in particular those difficulties for which no adequate technical solutions currently exist, or for which technical solutions do not seem to be appropriate, in the hope that our analysis of these stories will stimulate dialogue about the kinds of technical, social, and cultural solutions most needed to accelerate growth in better data management and sharing. Finally, we provide examples of how we have incorporated some of the researchers' data stories into the DataONE data management curriculum in order to support higher levels of engagement with the material and foster discussion among researchers about the complexities of the challenges they will likely encounter as they explore the world of data stewardship and reuse.

  9. Fighting the "Damnable Triumph" of Feminism: Battles between Teachers' Unions in Interwar Britain

    ERIC Educational Resources Information Center

    Wilson, Dolly Smith

    2007-01-01

    The interwar decades saw a bitter recruiting war between the NUT (National Union of Teachers), the National Union of Women Teachers (NUWT), and the National Association of Schoolmasters (NAS), which like the NUWT broke away from the NUT in the early 1920s. The NAS opposed the NUT's official policy shift to support equal pay for male and female…

  10. A Place on the Team: The Triumph and Tragedy of Title IX

    ERIC Educational Resources Information Center

    Suggs, Welch

    2006-01-01

    "A Place on the Team" is the inside story of how Title IX revolutionized American sports. The federal law guaranteeing women's rights in education, Title IX opened gymnasiums and playing fields to millions of young women previously locked out. Journalist Welch Suggs chronicles both the law's successes and failures-the exciting…

  11. Experiences of Secondary Hispanic Immigrant Students: Their Stories of Challenge and Triumph

    ERIC Educational Resources Information Center

    McCartney, Cynthia; Harris, Sandra; Farrow, Vicky

    2012-01-01

    Secondary Hispanic immigrant students have many struggles and barriers to overcome. This qualitative study investigated the experiences of 10 secondary immigrant Hispanic students, all non-English speakers, as they lived and attended high school in the United States. Narrative techniques were used to explore the challenges they faced in culture,…

  12. Digging for answers, smelling a hint of success and tasting triumph

    PubMed Central

    Noel, Joseph P

    2010-01-01

    The C12 ‘earthy’ odorant geosmin is derived from the C15 metabolite farnesyl diphosphate. Metabolic transformation now seems to be catalyzed by a bifunctional protein having two operatively independent sesquiterpene synthase domains. The domains are catalytically linked through the passive diffusion of a C15 alcohol product of the N-terminal catalytic domain to the C-terminal catalytic domain for the final steps of geosmin formation. PMID:17948014

  13. From Tragedy to Triumph: Counselor as Companion on the Hero's Journey.

    ERIC Educational Resources Information Center

    Halstead, Richard W.

    2000-01-01

    A counselor discusses his experiences while working with a male client on a "hero's journey," or the path to self-realization. The author explains how he grappled with what his role, as counselor, should be in this process. He concludes that he should act as the "hero's travel guide," someone who makes the clients' path shorter, smoother, or less…

  14. The Triumph and Tragedies of Japanese Women in America: A View across Four Generations

    ERIC Educational Resources Information Center

    Sakamoto, Taylor

    2007-01-01

    The author lives in a place filled with opportunities for girls like her. She is fortunate to attend school and enjoy activities like other young ladies. Her third- and fourth-generation parents encouraged her to attend Japanese Cultural School to learn about her heritage and to be proud of being Japanese-American. Her life has been filled with…

  15. Infectious diseases during the Civil War: the triumph of the "Third Army".

    PubMed

    Sartin, J S

    1993-04-01

    The American Civil War represents a landmark in military and medical history as the last large-scale conflict fought without knowledge of the germ theory of disease. Unsound hygiene, dietary deficiencies, and battle wounds set the stage for epidemic infection, while inadequate information about disease causation greatly hampered disease prevention, diagnosis, and treatment. Pneumonia, typhoid, diarrhea/dysentery, and malaria were the predominant illnesses. Altogether, two-thirds of the approximately 660,000 deaths of soldiers were caused by uncontrolled infectious diseases, and epidemics played a major role in halting several major campaigns. These delays, coming at a crucial point early in the war, prolonged the fighting by as much as 2 years.

  16. Piecing Together the Roman Empire: A Story of Discovery and Triumph.

    ERIC Educational Resources Information Center

    Richmond, Julie A.; And Others

    This story, written by middle school students and their teacher at Kingsbury School in Michigan, concerns the Ancient Roman Empire and is designed to be used to teach other middle school students. The story depicts a quest to reconstruct the Roman Empire from its beginnings as Ancient Italy, as a republic in the sixth century B.C., to the height…

  17. 3-D field computation: The near-triumph of commerical codes

    SciTech Connect

    Turner, L.R.

    1995-07-01

    In recent years, more and more of those who design and analyze magnets and other devices are using commercial codes rather than developing their own. This paper considers the commercial codes and the features available with them. Other recent trends with 3-D field computation include parallel computation and visualization methods such as virtual reality systems.

  18. I Thought You Were One of Us! Triumphs and Crisis When Teaching Your Own

    ERIC Educational Resources Information Center

    Heer, Kal

    2015-01-01

    Authoritative knowledge produced by white acacemics has forged much of the cannon in educational research. Recently, scholars of color, have been asserting their unique positionalities to conduct research and teach among their own communities. As a result they have provided a challenge to normative privilege whiteness in education. Claims of…

  19. The costs and benefits of writing, talking, and thinking about life's triumphs and defeats.

    PubMed

    Lyubomirsky, Sonja; Sousa, Lorie; Dickerhoof, Rene

    2006-04-01

    Three studies considered the consequences of writing, talking, and thinking about significant events. In Studies 1 and 2, students wrote, talked into a tape recorder, or thought privately about their worst (N = 96) or happiest experience (N = 111) for 15 min each during 3 consecutive days. In Study 3 (N = 112), students wrote or thought about their happiest day; half systematically analyzed, and half repetitively replayed this day. Well-being and health measures were administered before each study's manipulation and 4 weeks after. As predicted, in Study 1, participants who processed a negative experience through writing or talking reported improved life satisfaction and enhanced mental and physical health relative to those who thought about it. The reverse effect for life satisfaction was observed in Study 2, which focused on positive experiences. Study 3 examined possible mechanisms underlying these effects. Students who wrote about their happiest moments--especially when analyzing them--experienced reduced well-being and physical health relative to those who replayed these moments. Results are discussed in light of current understanding of the effects of processing life events.

  20. The triumph and tragedy of James Baxler Bean, MD, DDS (1834-1870).

    PubMed

    Christen, Arden G; Christen, Joan A

    2003-03-01

    In 1863, James Baxter Bean, a Southern physician and dentist, invented the interdental splint. This device was used to treat hundreds of Confederate soldiers who had received gun shot-related facial and jaw injuries during the Civil War. Made of vulcanized India-rubber, the splint provided a dramatic breakthrough in the treatment of maxillofacial wounds. In an Atlanta, Georgia hospital, Dr. Bean utilized his invention by establishing the first ward devoted exclusively to the treatment of jaw fractures. He also invented an apparatus that manufactured and administered nitrous oxide. Additionally, Bean's groundwork in casting aluminum as a denture base material led to Taggart's later invention (in 1907) of the casting machine. After the Civil War, Dr. Bean became a highly successful dentist, practicing in Baltimore, Maryland. In the fall of 1870, at age 36, Bean, representing the Smithsonian Institution in Washington, D.C., traveled to Europe to gather geological specimens. A short time after arriving, Bean decided to climb Mont Blanc with ten other men. The entire group perished in a raging 8-day snow storm on the mountain peak. This tragedy, a compelling drama, is legendary in the annals of mountaineering history. After Dr. Bean's passing, his wife lost her sanity and subsequently died. Later, the death of the couple's only child, Chapin, sadly ended the family line. Although his life was cut short, Bean's contributions to dentistry have been significant and far-reaching.

  1. When the Foundations Faculty Design Teacher Education: A Narrative of Triumphs and Tensions.

    ERIC Educational Resources Information Center

    Van Galen, Jane; Navarro, Janet

    2001-01-01

    Traces the development, by foundations faculty, of a Master of Education program, based in social foundations content and knowledge, discussing successes, tensions, and dilemmas they faced and explaining how foundational perspectives shaped the content of the curriculum they developed and how their perspectives illuminated the processes by which…

  2. The promotion and marketing of oxycontin: commercial triumph, public health tragedy.

    PubMed

    Van Zee, Art

    2009-02-01

    I focus on issues surrounding the promotion and marketing of controlled drugs and their regulatory oversight. Compared with noncontrolled drugs, controlled drugs, with their potential for abuse and diversion, pose different public health risks when they are overpromoted and highly prescribed. An in-depth analysis of the promotion and marketing of OxyContin illustrates some of the associated issues. Modifications of the promotion and marketing of controlled drugs by the pharmaceutical industry and an enhanced capacity of the Food and Drug Administration to regulate and monitor such promotion can have a positive impact on the public health.

  3. "Managing" the poor: neoliberalism, Medicaid HMOs and the triumph of consumerism among the poor.

    PubMed

    Maskovsky, J

    2000-10-01

    In order to explore the contradictions of neoliberal health policy, this article examines Medicaid managed care in Philadelphia. At the federal and state levels, government is increasingly promoting private-sector market-based strategies over policies formerly associated with the welfare state, arguing that the former are the most effective means of achieving economic growth and guaranteeing social welfare. A prime example of this shift, Medicaid managed care is a policy by which states contract with private-sector health maintenance organizations to provide health coverage to the poor. Drawing on ethnographic and historical data, this paper shows how Pennsylvania's Medicaid managed care program has created access barriers for poor Philadelphians. It also illustrates how ideologies that justify this policy shift serve to mask its detrimental effects on the poor. By contrasting the state's consumerist model with one group's protest efforts, this article calls into question the neoliberal ideology that undergirds health and welfare "reform."

  4. Artistic Triumph or Multicultural Failure?: Multiple Perspectives on a "Multicultural" Award-Winning Book.

    ERIC Educational Resources Information Center

    Smolkin, Laura B.; Suina, Joseph H.

    1997-01-01

    Explores the responses of a range of adults (all five Pueblo Indians) to one children's book, "Arrow to the Sun," based on a Pueblo Indian tale and written by a non-Indian. Discusses concerns for accuracy, authenticity, and sensitivity. Finds widely differing responses to the book among Eastern and Western Pueblo members. Reconsiders pedagogies,…

  5. Pioglitazone (Actos) and bladder cancer: Legal system triumphs over the evidence.

    PubMed

    Davidson, Mayer B

    2016-08-01

    In preclinical studies, pioglitazone was associated with bladder cancer in male rats (but not in female rats, mice dogs or monkeys). Because of this association, the Federal Drug Administration requested a large 10year epidemiological study to evaluate whether there was an association between bladder cancer and exposure to pioglitazone in patients. A 5-year interim report published in 2011 showed no significant association between ever vs never exposure to the drug but a significant association in patients exposed to pioglitazone for >2years. Importantly, the final 10year report did not confirm the 5year interim report finding no association between bladder cancer and pioglitazone, even after >4years of exposure to the drug. However, as would be expected, following the 5-year interim report, many epidemiological studies were carried out and civil litigation lawsuits began to be filed. Of the 23 epidemiological studies that have been published to date, 18 showed no association between bladder cancer and pioglitazone (5 with a combination of rosiglitazone and pioglitazone). Of the five that did show a significant association with pioglitazone, three could not be confirmed in the same population and in one of them there were significantly more risk factors for bladder cancer in the patients exposed to pioglitazone. In the fourth one, a significant association became non-significant when patients >79years were included. In the fifth one, detection bias was a major flaw. Currently, >11,000 legal cases have been filed, many of which claim emotional distress due to the fear of bladder cancer. To limit their legal costs, the pharmaceutical company has established a 2.4 billion dollar settlement pool. So much for evidence-based medicine.

  6. Triumph or Triage? The World Food Problem in Geographical Perspective. Resource Paper No. 75-3.

    ERIC Educational Resources Information Center

    Knight, C. Gregory; Wilcox, R. Paul

    Emphasizing a problem-solving perspective, the document investigates the world food scene. Simply defined, the world food problem is the apparent inability of the world's people to feed themselves adequately and consistently. Intended for use by college level geography instructors as they develop courses on human uses of the environment, the…

  7. A Triumph of Hope over Reason? Aid Accords and Education Policy in Kenya

    ERIC Educational Resources Information Center

    Colclough, Christopher; Webb, Andrew

    2012-01-01

    Despite a long history of post-independence aid to education, Kenya's relationships with overseas donors have, until recently, been markedly fractious. Donors' concerns about transparency and corruption, in the context of a political regime which became increasingly authoritarian, led to sharp reductions in aid to Kenyan education during the…

  8. The Mental Health Care Act No 17 - South Africa. Trials and triumphs: 2002-2012.

    PubMed

    Ramlall, S

    2012-11-01

    The Mental Health Care Act 17 of 2002 (MHCA) was promulgated in 2004. It has been hailed as one of the most progressive pieces of mental health legislation. A true measure of its merit is the degree to which it has transformed mental health services and in particular improved the quality of care. This paper will describe the impact of the Act on mental health care service delivery in the country. Literature pertaining to the MHCA published from 2006-2012, a report compiled by the South African Society of Psychiatrists and the results of a national survey conducted among Heads of Departments of Psychiatry, Mental Health Review Boards and Provincial Directors of Mental Health was reviewed. The MHCA has been successful in shifting the emphasis of care from psychiatric institutions to general hospitals. However, the integration of services has been hampered by infrastructure constraints and shortages of mental health personnel. It has been less successful in integrating mental health care into primary health services where the focus remains largely on the pharmacological maintenance treatment of the chronically mentally ill. Little attention has been given to the health promotion, disease prevention and rehabilitation aspects of care. Mental health review boards contend with limited resources, administrative challenges and limited political support. Isolated pockets of success characterised the implementation of the MHCA across the country. Greater investment of resources is needed to ensure the comprehensive implementation of the Act.

  9. The Rise, Fall and Subsequent Triumph of Thalidomide: Lessons Learned in Drug Development

    PubMed Central

    Rehman, Waqas; Arfons, Lisa M.; Lazarus, Hillard M.

    2011-01-01

    Perhaps no other drug in modern medicine rivals the dramatic revitalization of thalidomide. Originally marketed as a sedative, thalidomide gained immense popularity worldwide among pregnant women because of its effective anti-emetic properties in morning sickness. Mounting evidence of human teratogenicity marked a dramatic fall from grace and led to widespread social, legal and economic ramifications. Despite its tragic past thalidomide emerged several decades later as a novel and highly effective agent in the treatment of various inflammatory and malignant diseases. In 2006 thalidomide completed its remarkable renaissance becoming the first new agent in over a decade to gain approval for the treatment of plasma cell myeloma. The catastrophic collapse yet subsequent revival of thalidomide provides important lessons in drug development. Never entirely abandoned by the medical community, thalidomide resurfaced as an important drug once the mechanisms of action were further studied and better understood. Ongoing research and development of related drugs such as lenalidomide now represent a class of irreplaceable drugs in hematological malignancies. Further, the tragedies associated with this agent stimulated the legislation which revamped the FDA regulatory process, expanded patient informed consent procedures and mandated more transparency from drug manufacturers. Finally, we review recent clinical trials summarizing selected medical indications for thalidomide with an emphasis on hematologic malignancies. Herein, we provide a historic perspective regarding the up-and-down development of thalidomide. Using PubMed databases we conducted searches using thalidomide and associated keywords highlighting pharmacology, mechanisms of action, and clinical uses. PMID:23556097

  10. Social Determinants and Disparities in Health: Their Crucifixion, Resurrection, and Ultimate Triumph(?) in Health Policy.

    PubMed

    House, James S

    2016-08-01

    David Mechanic has been a principal founder of modern sociological and social science approaches to health, especially in relation to health policy. These approaches have since the 1950s and 1960s resurrected ideas that had currency in the mid-nineteenth century but seemed crucified, dead, and buried by the rise of modern biomedicine from the mid-nineteenth century through the mid-twentieth century. Problems and lacunae in purely biomedical approaches to health in the later twentieth century, along with developments of new biopsychosocial approaches to health, have spawned a return toward ideas of Rudolf Virchow and mid-nineteenth-century social medicine that social determinants and disparities are major drivers of population health. Since individual health and population health constitute the major determinants of health care utilization and expenditures, social determinants and disparities in health are arguably the foundation of a new "demand-side" health policy that can resolve America's paradoxical health policy crisis of spending increasingly more than any nation on health care and insurance yet achieving increasingly worsening health outcomes relative to virtually all developed countries and some developing ones as well, something that current "supply-side" health policy, including Obamacare, cannot do, important as it is for expanding access to health insurance and care.

  11. Using Neural Progenitor Cells in High-Throughput Screens for Developmental Neurotoxicants: Triumphs and Tragedies

    EPA Science Inventory

    Current protocols for developmental neurotoxicity testing are insufficient to test thousands of commercial chemicals. Thus, development of highthroughput screens (HTS) to detect and prioritize chemicals that may cause developmental neurotoxicity is needed to improve protection of...

  12. Benefits of voluntary industry standards: The triumph of experience over regulation

    SciTech Connect

    O`Leary, J.T.

    1996-12-31

    Voluntary international standards for mining machinery may gradually replace many national regulations. The days of establishing voluntary standards nation by nation, inhibiting the important flow of international trade, could be numbered. This does not mean that nations will cease domestic regulatory activities within their boundaries, but rulemaking will pay considerable attention to voluntary international standards and will likely strive for compatibility with voluntary international standards. International standards setting bodies are developing standards for machine safety. When these standards are complete and adopted, some nations will require machinery to comport with them. International commerce in products that do not conform to these voluntary international standards may be discouraged.

  13. Flat-panel electronic displays: a triumph of physics, chemistry and engineering.

    PubMed

    Hilsum, Cyril

    2010-03-13

    This paper describes the history and science behind the development of modern flat-panel displays, and assesses future trends. Electronic displays are an important feature of modern life. For many years the cathode ray tube, an engineering marvel, was universal, but its shape was cumbersome and its operating voltage too high. The need for a flat-panel display, working at a low voltage, became imperative, and much research has been applied to this need. Any versatile flat-panel display will exploit an electro-optical effect, a transparent conductor and an addressing system to deliver data locally. The first need is to convert an electrical signal into a visible change. Two methods are available, the first giving emission of light, the second modulating ambient illumination. The most useful light-emitting media are semiconductors, historically exploiting III-V or II-VI compounds, but more recently organic or polymer semiconductors. Another possible effect uses gas plasma discharges. The modulating, or subtractive, effects that have been studied include liquid crystals, electrophoresis, electrowetting and electrochromism. A transparent conductor makes it possible to apply a voltage to an extended area while observing the results. The design is a compromise, since the free electrons that carry current also absorb light. The first materials used were metals, but some semiconductors, when heavily doped, give a better balance, with high transmission for a low resistance. Delivering data unambiguously to a million or so picture elements across the display area is no easy task. The preferred solution is an amorphous silicon thin-film transistor deposited at each cross-point in an X-Y matrix. Success in these endeavours has led to many applications for flat-panel displays, including television, flexible displays, electronic paper, electronic books and advertising signs.

  14. The Triumph of Religious Education for Citizenship in English Schools, 1935-1949

    ERIC Educational Resources Information Center

    Freathy, Rob

    2008-01-01

    The failure of the Association for Education in Citizenship to gain official support for the secular and pedagogically progressive forms of education for citizenship that its founder members endorsed has previously been explained by the political impotence of the association's founder members and the professional conservatism of the educational…

  15. From Tragedy to Triumph - Rebuilding Green Homes after Disaster (Fact Sheet)

    SciTech Connect

    Not Available

    2009-04-01

    Energy Efficiency/Renewable Energy Fact Sheets, No. 1. Series to include practical, useful info to help people change their behavior around energy usage and "greenness". Greensburg is hanging its future on sustainable development; these fact sheet sheets should help citizens understand what they can do to be a part of that focus. Fact Sheets cover: saving energy and water, using renewable energy (particular interest in small wind), driving "green", general sustainability, living green.

  16. From Tragedy to Triumph - Rebuilding Green Buildings after Disaster, EERE (Fact Sheet)

    SciTech Connect

    Not Available

    2009-10-01

    Fact sheet offering practical information about building energy efficient buildings and using renewable energy. Includes a checklist and resources. Highlights successful projects in Greensburg, Kansas.

  17. The Chennai Declaration: India's landmark national commitment to antibiotic stewardship demonstrates that 'truth alone triumphs'.

    PubMed

    Holmes, A H; Sharland, M

    2013-07-01

    A joint meeting of the medical societies in India took place in Chennai in August 2012, giving rise to national recommendations and an action plan to address the challenge of antimicrobial resistance in India. The 'Chennai Declaration', published in November 2012, has a pragmatic achievable plan and represents a bold national commitment to antibiotic stewardship and infection control across India. The global importance of implementing such an antibiotic policy as a national strategy needs to be recognized and supported internationally.

  18. Human Error and the International Space Station: Challenges and Triumphs in Science Operations

    NASA Technical Reports Server (NTRS)

    Harris, Samantha S.; Simpson, Beau C.

    2016-01-01

    Any system with a human component is inherently risky. Studies in human factors and psychology have repeatedly shown that human operators will inevitably make errors, regardless of how well they are trained. Onboard the International Space Station (ISS) where crew time is arguably the most valuable resource, errors by the crew or ground operators can be costly to critical science objectives. Operations experts at the ISS Payload Operations Integration Center (POIC), located at NASA's Marshall Space Flight Center in Huntsville, Alabama, have learned that from payload concept development through execution, there are countless opportunities to introduce errors that can potentially result in costly losses of crew time and science. To effectively address this challenge, we must approach the design, testing, and operation processes with two specific goals in mind. First, a systematic approach to error and human centered design methodology should be implemented to minimize opportunities for user error. Second, we must assume that human errors will be made and enable rapid identification and recoverability when they occur. While a systematic approach and human centered development process can go a long way toward eliminating error, the complete exclusion of operator error is not a reasonable expectation. The ISS environment in particular poses challenging conditions, especially for flight controllers and astronauts. Operating a scientific laboratory 250 miles above the Earth is a complicated and dangerous task with high stakes and a steep learning curve. While human error is a reality that may never be fully eliminated, smart implementation of carefully chosen tools and techniques can go a long way toward minimizing risk and increasing the efficiency of NASA's space science operations.

  19. African-American Firsts. Famous, Little-Known and Unsung Triumphs of Blacks in America.

    ERIC Educational Resources Information Center

    Potter, Joan; Claytor, Constance

    Stories of more than 400 "firsts" by African Americans, break-through achievements in a variety of fields, are told in question-and-answer form ("Who was the first African American to ...?"). These are stories of people who were forced to contend with racism, directly or indirectly, in their struggle towards goals that require…

  20. Russian war surgery in 1812: 200 years since Russia's war triumph.

    PubMed

    Boсkeria, Leo A; Glyantsev, Sergey P; Kolesnikov, Yan G

    2012-01-01

    Specific wounds inflicted on soldiers and officers of the Russian Army by French firearms and cold weapon and wound treatment by Russian surgeons during 1812 Napoleon's invasion (better known in Russia as the Patriotic War of 1812) are discussed. An inference is made that the then surgical treatment was not only administered at a high level but was also versatile and efficient and thus could make a certain contribution to the victory of the Russian arms.

  1. Triumphs Show: Getting Year 10 beyond Trivial Judgements of "Bias": Towards Victory in "That" Battle …

    ERIC Educational Resources Information Center

    Hinks, Thomas

    2014-01-01

    Back in 1993 and 2000, Lang and LeCocq, respectively, in their reactions against reductive and de-contextualised forms of "source work", pointed out that all sources do hold value in some way, even, and often especially, in those aspects that might be deemed "biased". The author's Year 10s' difficulty in shaking off a…

  2. Post Civil War African American History: Brief Periods of Triumph, and Then Despair.

    PubMed

    Graff, Gilda

    2016-01-01

    During Reconstruction, which is often called the most progressive period in American history, African Americans made great strides. By 1868 African American men constituted a majority of registered voters in South Carolina and Mississippi, and by 1870 eighty-five percent of Mississippi's black jurors could read and write. However, Reconstruction was followed by approximately one hundred years of Jim Crow laws, lynching, disenfranchisement, sharecropping, unequal educational resources, terrorism, racial caricatures, and convict leasing. The Civil Rights Revolution finally ended that period of despair, but the era of mass incarceration can be understood as a reaction to the Civil Rights Movement. This article attempts to understand the persistence of racism in the United States from slavery's end until the present.

  3. Flat-panel electronic displays: a triumph of physics, chemistry and engineering

    PubMed Central

    Hilsum, Cyril

    2010-01-01

    This paper describes the history and science behind the development of modern flat-panel displays, and assesses future trends. Electronic displays are an important feature of modern life. For many years the cathode ray tube, an engineering marvel, was universal, but its shape was cumbersome and its operating voltage too high. The need for a flat-panel display, working at a low voltage, became imperative, and much research has been applied to this need. Any versatile flat-panel display will exploit an electro-optical effect, a transparent conductor and an addressing system to deliver data locally. The first need is to convert an electrical signal into a visible change. Two methods are available, the first giving emission of light, the second modulating ambient illumination. The most useful light-emitting media are semiconductors, historically exploiting III–V or II–VI compounds, but more recently organic or polymer semiconductors. Another possible effect uses gas plasma discharges. The modulating, or subtractive, effects that have been studied include liquid crystals, electrophoresis, electrowetting and electrochromism. A transparent conductor makes it possible to apply a voltage to an extended area while observing the results. The design is a compromise, since the free electrons that carry current also absorb light. The first materials used were metals, but some semiconductors, when heavily doped, give a better balance, with high transmission for a low resistance. Delivering data unambiguously to a million or so picture elements across the display area is no easy task. The preferred solution is an amorphous silicon thin-film transistor deposited at each cross-point in an X–Y matrix. Success in these endeavours has led to many applications for flat-panel displays, including television, flexible displays, electronic paper, electronic books and advertising signs. PMID:20123746

  4. The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future

    PubMed Central

    Tseng, Alice; Seet, Jason; Phillips, Elizabeth J

    2015-01-01

    The evolution of human immunodeficiency virus (HIV) treatment has improved our understanding and management of complex pharmacological issues that have driven improved outcomes and quality of life of the HIV-infected patient. These issues include adherence, long- and short-term toxicities, pharmacoenhancement, pharmacogenomics, therapeutic drug monitoring, differential penetration of drugs into sanctuary sites, such as the central nervous system, genital tract and small bowel, and drug–drug and drug–food interactions related to cytochrome P450 drug-metabolizing enzymes, uridine diphosphate glucuronyltransferases and drug transporters, to name a few. There is future promise, as an increased understanding of the immunopathogenesis of HIV and global public health initiatives are driving novel treatment approaches with goals to prevent, control and, ultimately, eradicate HIV. PMID:24730660

  5. From Tragedy to Triumph: Rebuilding Greensburg, Kansas To Be a 100% Renewable Energy City; Preprint

    SciTech Connect

    Pless, S.; Billman, L.; Wallach, D.

    2010-08-01

    On May 4, 2007, Greensburg, Kansas, was hit by a 1.7-mile wide tornado with 200 mph-plus wind speeds. This tornado destroyed or severely damaged 90% of Greensburg?s structures. We discuss the progress made in rebuilding Greensburg, with a focus on the built environment and on meeting Greensburg?s goal of 100% renewable energy, 100% of the time. We also discuss key disaster recovery efforts that enabled Greensburg to reach this goal. Key strategies included a Sustainable Comprehensive Master Plan, an ordinance resolving that city-owned buildings achieve LEED Platinum and 42% energy savings, a strong focus on rebuilding 'right' with an integrated design process, attracting significant and sustained technical experts and national media attention, and linking renewable and energy efficiency technologies to business development. After three years, more than half the homes that have been rebuilt are rated at an average of 40% energy savings. All significant commercial buildings, including the school, hospital, banks, courthouse, and retail buildings, have been rebuilt to LEED Gold and Platinum standards and exceed 40% savings, with many exceeding 50% savings. Greensburg recently constructed a 12.5-MW community wind farm to provide all the remaining energy needed for its energy-efficient buildings and homes.

  6. The Triumph of the Industrial-Consumer Paradigm and English as the Global Language

    ERIC Educational Resources Information Center

    Spring, Joel

    2007-01-01

    This article considers the role of English as the global language within the industrial-consumer paradigm. In the 21st century, the English language plays a different function in the global economy than it did during the 19th century when it was used as an instrument of cultural imperialism. Today, English serves as a vehicle for participation in…

  7. Canada in the 21st Century - Triumph or Tragedy? The Front Line.

    ERIC Educational Resources Information Center

    Kilgour, David

    1996-01-01

    Argues that new patterns of trade and production combined with an emphasis on a knowledge-based economy/society make it imperative that Canada upgrade its educational system. Specifically notes that several growing and dominant industries (microelectronics, biotechnology, telecommunications) require a high-tech skilled labor force. (MJP)

  8. Anatomy of a Municipal Triumph: New York City's Upsurge in Life Expectancy

    PubMed Central

    Preston, Samuel H.; Elo, Irma T.

    2014-01-01

    Over the period 1990–2010, the increase in life expectancy for males in New York City was 6.0 years greater than for males in the United States. The female relative gain was 3.9 years. Male relative gains were larger because of extremely rapid reductions in mortality from HIV/AIDS and homicide, declines that reflect effective municipal policies and programs. Declines in drug- and alcohol-related deaths also played a significant role in New York City's advance, but every major cause of death contributed to its relative improvement. By 2010, New York City had a life expectancy that was 1.9 years greater than that of the US. This difference is attributable to the high representation of immigrants in New York's population. Immigrants to New York City, and to the United States, have life expectancies that are among the highest in the world. The fact that 38 percent of New York's population consists of immigrants, compared to only 14 percent in the United States, accounts for New York's exceptional standing in life expectancy in 2010. In fact, US-born New Yorkers have a life expectancy below that of the United States itself. PMID:25843989

  9. Triumph and adversity: Exploring the complexities of consumer storytelling in mental health nursing education.

    PubMed

    Happell, Brenda; Bennetts, Wanda

    2016-12-01

    Consumer participation in the education of health professionals is increasing, particularly in mental health nursing education and storytelling remains the most frequent approach to consumer involvement. The use of story has tended to be accepted as a legitimate educational tool with limited critique or consideration of its potential consequences presented within the academic literature. A qualitative exploratory research study was undertaken with mental health nurse academics (n = 34) and consumer educators and academics (n = 12), to investigate the perceptions and experiences of mental health nurses and consumers regarding the involvement of consumers in mental health nursing education. Data were analysed thematically. Story was a major theme to emerge from consumer participants and received some attention from nurse academics. Consumers and nurses both referred to the power of story to convey the human experience of mental illness diagnosis and service use; and the vulnerability that can result from storytelling. Consumers also described: story as expectation; preparation and support; and the politics of story. All participants supported the value of storytelling in mental health nursing education. Consumers had considered the complexities in far greater detail. The ongoing value of story as an educational technique requires further research. Equally important is considering a broader range of educational roles for mental health consumers.

  10. Program Converts VAX Floating-Point Data To UNIX

    NASA Technical Reports Server (NTRS)

    Alves, Marcos; Chapman, Bruce; Chu, Eugene

    1996-01-01

    VAX Floating Point to Host Floating Point Conversion (VAXFC) software converts non-ASCII files to unformatted floating-point representation of UNIX machine. This is done by reading bytes bit by bit, converting them to floating-point numbers, then writing results to another file. Useful when data files created by VAX computer must be used on other machines. Written in C language.

  11. Even during Hiring Freezes, Many Colleges Stick with Sustainability Plans

    ERIC Educational Resources Information Center

    Carlson, Scott

    2009-01-01

    Michael J. O'Connor, the physical-plant director at Appalachian State University, is watching his staff shrink bit by bit. When people leave, he's not rehiring. There is one exception to his staffing plan, however. Despite the economic duress, he is conducting a national search for a sustainability director. The university has ambitious…

  12. Triumph of the Heart - The Story of Statins Jack Li Jie Triumph of the Heart - The Story of Statins 218pp Oxford University Press 9780195323573 0195323572 [Formula: see text].

    PubMed

    2010-11-03

    Statins have helped to control high cholesterol, one of the three major risk factors for coronary heart disease (CHD). Jie Jack Li, a medicinal chemist at Pfizer Global Research and Development, offers a fascinating pharmaceutical account of the history of statins, from initial discovery and animal and clinical trials to large-scale manufacturing and marketing.

  13. The trials, tribulations, and triumphs of black faculty in the math and science pipeline: A life history approach

    NASA Astrophysics Data System (ADS)

    Williams, Lisa D.

    2000-12-01

    This study explores the career progression and life history of black mathematicians and scientists who teach on university faculties in the United States. It investigates the following questions: Why are there so few black mathematicians and scientists in colleges and universities in the United States? What is the experience of black students who express an interest in science and math? What barriers do black scientists and mathematicians face as they move through school towards their career in higher education? What factors facilitate their success? The current literature shows that there are few women and minorities teaching or working in math and science compared to white men, although reasons for this underrepresentation are still not well understood. I explored this phenomenon by conducting two sets of in-depth interviews with twelve black faculty, six women, six men, from both historically black and predominantly white higher educational institutions in the United States. My interviews were based upon a life history approach that identified the participants' perceptions of the barriers and obstacles, as well as the supports and facilitators encountered in their schooling and career progression. The findings from the study show the importance of a strong family, community, and teacher support for the participants throughout their schooling. Support systems continued to be important in their faculty positions. These support systems include extended family members, teachers, community members, supervisors, and classmates, who serve as role models and mentors. The life study interviews provide striking evidence of the discrimination, isolation, and harassment due to race and gender experienced by black male and female mathematicians and scientists. The racial discrimination and the compounding effect of racism and sexism play out differently for the male and female participants in this study. This study suggests directions for future research on the experiences of young black students who are currently in the math and science educational pipeline. It also offers recommendations for ways in which parents, teachers, administrators, faculty, advisors, and government officials can enhance the educational experiences of black students who express interest and have skills in math and science.

  14. Images of Struggle and Triumph: Using Picture Books to Teach about the Civil Rights Movement in the Secondary Classroom

    ERIC Educational Resources Information Center

    Wilkins, Karen H.; Sheffield, Caroline C.; Ford, Martha B.; Cruz, Barbara C.

    2008-01-01

    This article describes four picture books ("Mississippi Morning" written by Ruth Vander Zee, "Dad, Jackie, and Me" written by Myron Uhlberg, "Freedom on the Menu" written by Carole Boston Weatherford, and "A Sweet Smell of Roses" written by Angela Johnson) that provide a concise (yet nuanced) chronicle of the civil rights movement--from the Jim…

  15. The Acquisition of Cultural Competence: A Phenomenological Inquiry Highlighting the Processes, Challenges and Triumphs of Counselor Education Graduate Students

    ERIC Educational Resources Information Center

    Garner, Douglas L.

    2012-01-01

    Although research has effectively isolated and identified the key characteristics of a culturally competent counselor, there are few studies regarding the acquisition of these characteristics. To close the gap between theory and practice, studies are needed researching the emergence and, acquisition of these characteristics. This study explores…

  16. Trouble and Triumph: German Life-Turkish Tradition in Renan Demirkan's "Schwarzer Tee mit drei Stuck Zucker"

    ERIC Educational Resources Information Center

    Ebert, Reika

    2004-01-01

    This paper explores Demirkan's narrative strategies in "Schwarzer Tee mit drei Stuck Zucker" to negotiate issues of a life between two cultures and traditions. Based on Bhabha's insights that mainstream culture needs intellectual and artistic infusion from the margins of a society in order to remain vital; and that cultural production…

  17. Bridge of Signs: Can Sign Language Empower Non-Deaf Children to Triumph over Their Communication Disabilities?

    ERIC Educational Resources Information Center

    Toth, Anne

    2009-01-01

    This pilot research project examined the use of sign language as a communication bridge for non-Deaf children between the ages of 0-6 years who had been diagnosed with, or whose communication difficulties suggested, the presence of such disorders as Autism, Down Syndrome, Fetal Alcohol Spectrum Disorder (FASD), and/or learning disabilities.…

  18. "A triumph of brains over brute": women and science at the Horticultural College, Swanley, 1890-1910.

    PubMed

    Opitz, Donald L

    2013-03-01

    The founding of Britain's first horticultural college in 1889 advanced a scientific and coeducational response to three troubling national concerns: a major agricultural depression; the economic distress of single, unemployed women; and imperatives to develop the colonies. Buoyed by the technical instruction and women's movements, the Horticultural College and Produce Company, Limited, at Swanley, Kent, crystallized a transformation in the horticultural profession in which new science-based, formalized study threatened an earlier emphasis on practical apprenticeship training, with the effect of opening male-dominated trades to women practitioners. By 1903, the college closed its doors to male students, and new pathways were forged for women students interested in pursuing further scientific study. Resistance to the Horticultural College's model of science-based women's horticultural education positioned science and women as contested subjects throughout this period of horticulture's expansion in the academy.

  19. Detection of HLA Antibodies in Organ Transplant Recipients – Triumphs and Challenges of the Solid Phase Bead Assay

    PubMed Central

    Tait, Brian D.

    2016-01-01

    This review outlines the development of human leukocyte antigen (HLA) antibody detection assays and their use in organ transplantation in both antibody screening and crossmatching. The development of sensitive solid phase assays such as the enzyme-linked immunosorbent assay technique, and in particular the bead-based technology has revolutionized this field over the last 10–15 years. This revolution however has created a new paradigm in clinical decision making with respect to the detection of low level pretransplant HLA sensitization and its clinical relevance. The relative sensitivities of the assays used are discussed and the relevance of conflicting inter-assay results. Each assay has its advantages and disadvantages and these are discussed. Over the last decade, the bead-based assay utilizing the Luminex® fluorocytometer instrument has become established as the “gold standard” for HLA antibody testing. However, there are still unresolved issues surrounding this technique, such as the presence of denatured HLA molecules on the beads which reveal cryptic epitopes and the issue of appropriate fluorescence cut off values for positivity. The assay has been modified to detect complement binding (CB) in addition to non-complement binding (NCB) HLA antibodies although the clinical relevance of the CB and NCB IgG isotypes is not fully resolved. The increase sensitivity of the Luminex® bead assay over the complement-dependent cytotoxicity crossmatch has permitted the concept of the “virtual crossmatch” whereby the crossmatch is predicted to a high degree of accuracy based on the HLA antibody specificities detected by the solid phase assay. Dialog between clinicians and laboratory staff on an individual patient basis is essential for correct clinical decision making based on HLA antibody results obtained by the various techniques. PMID:28018342

  20. Love is the triumph of the imagination: Daydreams about significant others are associated with increased happiness, love and connection.

    PubMed

    Poerio, Giulia L; Totterdell, Peter; Emerson, Lisa-Marie; Miles, Eleanor

    2015-05-01

    Social relationships and interactions contribute to daily emotional well-being. The emotional benefits that come from engaging with others are known to arise from real events, but do they also come from the imagination during daydreaming activity? Using experience sampling methodology with 101 participants, we obtained 371 reports of naturally occurring daydreams with social and non-social content and self-reported feelings before and after daydreaming. Social, but not non-social, daydreams were associated with increased happiness, love and connection and this effect was not solely attributable to the emotional content of the daydreams. These effects were only present when participants were lacking in these feelings before daydreaming and when the daydream involved imagining others with whom the daydreamer had a high quality relationship. Findings are consistent with the idea that social daydreams may function to regulate emotion: imagining close others may serve the current emotional needs of daydreamers by increasing positive feelings towards themselves and others.

  1. Triumph or Tragedy: Comparing Student Engagement Levels of Members of Greek-Letter Organizations and Other Students.

    ERIC Educational Resources Information Center

    Hayek, John C.; Carini, Robert M.; O'Day, Patrick T.; Kuh, George D.

    2002-01-01

    This study compared the levels of student engagement between fraternity and sorority members and other undergraduate students. After controls, Greek members appeared to be equally and sometimes more engaged in academically challenging tasks, active learning, student-faculty interaction, community service, diversity, satisfaction, and on learning…

  2. News from Front (of the Solar System): the problem with Mercury, the Vulcan hypothesis, and General Relativity's first astronomical triumph

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2016-01-01

    The discovery of the outer planet Neptune in 1846, based on the calculated position published by Urbain Jean Joseph Le Verrier, has been hailed as the "zenith of Newtonian mechanics." An attempt by Le Verrier to further extend the dominion of Newton's gravitational theory to the innermost known planet of the Solar System, Mercury, seemingly came to grief with the discovery of a small unexplained discrepancy in the precession of the perihelion of Mercury, whose value was later calculated as 43".0 per century. Le Verrier proposed that it could be explained on the basis of Newtonian theory by assuming the existence of an intra-mercurial planet ("Vulcan") or ring of debris. Efforts to confirm this hypothesis, culminating in high drama on the plains of the western United States at the great North American solar eclipse of July 1878, proved futile; by 1908, W. W. Campbell and C.D. Perrine of Lick Observatory, who had carried out exhaustive photographic searches at three eclipses (1901, 1905, and 1908) could declare that Vulcan did not exist. The theoretical problem it was invoked to explain remained until November 1915, when Albert Einstein used the recently discovered generally covariant gravitational equations to put the problem to rest. "Perihelion motions explained quantitatively … you will be astonished," he wrote to his friend Michael Besso.

  3. S. Burt Wolbach, Rocky Mountain spotted fever, and blood-sucking arthropods: triumph of an early investigative pathologist.

    PubMed

    Musser, James M

    2013-02-01

    In a series of four articles published between 1916 and 1919 in The Journal of Medical Research, precursor to The American Journal of Pathology, the investigative pathologist S. Burt Wolbach unambiguously showed that Rocky Mountain spotted fever has a tick-borne mode of transmission, the causative agent replicates intracellularly, and the disease is fundamentally a vasculitis. Although underappreciated, Wolbach's tour-de-force work epitomized investigative pathology. These four articles should be mandatory reading for young investigators and are recommended also to seasoned investigators who seek reinvigoration in the beauty in their craft.

  4. Under severe HLB and citrus canker pressure, 'Triumph' and 'Jackson' perform better than 'Flame' and 'Marsh' grapefruit

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Huanglongbing (HLB) and Citrus Canker (CC) threaten the viability of Florida grapefruit production. ‘Triumph’ (T), reportedly a grapefruit/sweet orange hybrid, is similar to seedy white grapefruit with earlier maturity and lower bitterness. ‘Jackson’ (J) is a low-seeded budsport of ‘Triumph’. Tree h...

  5. The Tragedy and Triumph of Minamata: A Paradigm for Understanding Ecological, Human-Environment and Culture-Technology Interactions.

    ERIC Educational Resources Information Center

    Allchin, Douglas

    1999-01-01

    Contends that the example of mercury poisoning in Minamata, Japan can be used as a paradigm for teaching ecology and science-and-society issues. Discusses the history and science of the pollution and poisoning, and considers the social and cultural consequences of the incident, some aspects of causation and responsibility, and some aspects of…

  6. Inspiration in the harness of daily labor. Darwin, botany, and the triumph of evolution, 1859-1868.

    PubMed

    Bellon, Richard

    2011-09-01

    Charles Darwin hoped that a large body of working naturalists would embrace evolution after the Origin of Species appeared in late 1859. He was disappointed. His evolutionary ideas at first made painfully little progress in the scientific community. But by 1863 the tide had turned dramatically, and within five years evolution became scientific orthodoxy in Britain. The Origin's reception followed this peculiar trajectory because Darwin had not initially tied its theory to productive original scientific investigation, which left him vulnerable to charges of reckless speculation. The debate changed with his successful application of evolution to original problems, most notably orchid fertilization, the subject of a well-received book in 1862. Most of Darwin's colleagues found the argument of the Origin convincing when they realized that it functioned productively in the day-to-day work of science-and not before. The conceptual force of the Origin, however outwardly persuasive, acquired full scientific legitimacy only when placed "in the harness of daily labour".

  7. John Collins Warren and his act of conscience: a brief narrative of the trial and triumph of a great surgeon.

    PubMed Central

    Moore, F D

    1999-01-01

    On examination of the correspondence among the principals involved, as well as the original patent application being prepared by Morton, it has become possible to reconstruct some of the remarkable details attending the first use of ether anesthesia at the Massachusetts General Hos pital in the autumn of 1846. At the time that Warren invited Morton to demonstrate the use of his "ethereal vapor" for anesthesia in a minor operation on Oct. 16, 1846, the exact chemical composition of the agent used was being held secret by Morton; Warren was clearly disturbed by this unethical use of a secret "nostrum." When the time arrived 3 weeks later for its possible use for a serious "capital" operation, Warren employed a simple stratagem of public confrontation to discover from Morton the true nature of the substance to be used. On being informed that it was pure unadulterated sulfuric ether, not some mysterious new discovery labeled "Letheon," Warren gave approval for its first use in a "capital" operation (low thigh amputation) on Nov. 7, 1846. Despite this revelation to the immediate participants, a veil of secrecy continued to surround the substance for many months, an anomalous situation evidently traceable to Morton's desire for personal reward from the discovery. It was this matter of secrecy, rather than priority for its discovery, that surrounded the early use of ether anesthesia with controversy and recrimination both in this country and abroad. Images Figure 2. PMID:10024099

  8. Sunday Sport Comes to Pennsylvania: Professional Baseball and Football Triumph over the Commonwealth's Archaic Blue Laws, 1919-1933.

    ERIC Educational Resources Information Center

    Jable, J. Thomas

    Following World War I, many Americans plunged into sport, and found the Sabbath a convenient and popular day for engaging in sporting events, especially since Sunday activities had become commonplace during the War and acceptable in many areas. However, when Pennsylvanians turned to sport on the Sabbath, they were confronted by the state's archaic…

  9. Satellite Communication Hardware Emulation System (SCHES)

    NASA Technical Reports Server (NTRS)

    Kaplan, Ted

    1993-01-01

    Satellite Communication Hardware Emulator System (SCHES) is a powerful simulator that emulates the hardware used in TDRSS links. SCHES is a true bit-by-bit simulator that models communications hardware accurately enough to be used as a verification mechanism for actual hardware tests on user spacecraft. As a credit to its modular design, SCHES is easily configurable to model any user satellite communication link, though some development may be required to tailor existing software to user specific hardware.

  10. A Comparison and Analysis of Army Generals and Executives.

    DTIC Science & Technology

    1981-12-01

    the timing and of strategy of communicating a decision. Top military leaders are able to deliver interpersonal feedback, to read nonverbal as well as...42 o- synthesis which goes beyond the mere putting together of the product of analysis bit by bit. This means that some fervor, warmth of perception...as regards both structure of interpersonal relations and syntality characteristics. Furthermore, the theory takes into account those studies that 48

  11. What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?

    PubMed

    Becker, Robert E; Seeman, Mary V; Greig, Nigel H; Lahiri, Debomoy K

    2015-08-01

    Drug development for psychiatric disorders has almost ground to a halt. Some newer drugs are better tolerated or safer than older ones, but none is more effective. Years of failure in preventing or delaying the onset of illness, ameliorating symptoms, lowering suicide rates, or improving quality of life has put the commercial investments that had previously funded drug development at risk. To promote the development of psychiatric drugs with greater efficacy, we need to improve the way we bring potentially beneficial drugs to market. We need to acknowledge, as has been done in other specialties, that people differ in their response to drugs. Psychiatric drug research needs to be grounded in a better understanding of molecular brain mechanisms, neural circuits, and their relations to clinical disease. With this understanding, drugs need to be more precisely directed at specific brain targets. In psychiatric drug development, government, industry, regulatory bodies, and academia should realign to ensure medical science is used in the best interests of patients.

  12. Tomorrow's Families: Triumph of the Individual or Sharing the Caring? (Les familles de demain: Triomphe de l'individu ou partage des soins a donner?).

    ERIC Educational Resources Information Center

    Theilheimer, Ish, Ed.

    1993-01-01

    This theme issue of the Canadian newsletter "Transitions" in both English and French explores the question of the future of families in a period of broken marriages, difficult times, and an obsession with individual success and materialism. "Families of the Future: New Ways to Do the Same Old Things," summarizes the findings of…

  13. "Akeelah and the Bee": Inspirational Story of African-American Intellect and Triumph or Racist Rhetoric Served Up on Another Platter?

    ERIC Educational Resources Information Center

    Pimentel, Charise; Sawyer, Cathleen

    2011-01-01

    In this article, the authors look into the inspirational movie, "Akeelah and the Bee," a film about an African-American who goes against all odds to achieve success in grand proportions. Described as an "inspirational family film" and a "successful feel-good movie" (Turan, 2006), "Akeelah and the Bee" proved inspirational to many viewers, as it…

  14. Triumph of hope over experience: learning from interventions to reduce avoidable hospital admissions identified through an Academic Health and Social Care Network

    PubMed Central

    2012-01-01

    Background Internationally health services are facing increasing demands due to new and more expensive health technologies and treatments, coupled with the needs of an ageing population. Reducing avoidable use of expensive secondary care services, especially high cost admissions where no procedure is carried out, has become a focus for the commissioners of healthcare. Method We set out to identify, evaluate and share learning about interventions to reduce avoidable hospital admission across a regional Academic Health and Social Care Network (AHSN). We conducted a service evaluation identifying initiatives that had taken place across the AHSN. This comprised a literature review, case studies, and two workshops. Results We identified three types of intervention: pre-hospital; within the emergency department (ED); and post-admission evaluation of appropriateness. Pre-hospital interventions included the use of predictive modelling tools (PARR – Patients at risk of readmission and ACG – Adjusted Clinical Groups) sometimes supported by community matrons or virtual wards. GP-advisers and outreach nurses were employed within the ED. The principal post-hoc interventions were the audit of records in primary care or the application of the Appropriateness Evaluation Protocol (AEP) within the admission ward. Overall there was a shortage of independent evaluation and limited evidence that each intervention had an impact on rates of admission. Conclusions Despite the frequency and cost of emergency admission there has been little independent evaluation of interventions to reduce avoidable admission. Commissioners of healthcare should consider interventions at all stages of the admission pathway, including regular audit, to ensure admission thresholds don’t change. PMID:22682525

  15. The market triumph of ecotourism: an economic investigation of the private and social benefits of competing land uses in the Peruvian Amazon.

    PubMed

    Kirkby, Christopher A; Giudice-Granados, Renzo; Day, Brett; Turner, Kerry; Velarde-Andrade, Luz Marina; Dueñas-Dueñas, Agusto; Lara-Rivas, Juan Carlos; Yu, Douglas W

    2010-09-29

    Annual revenue flow to developing countries for ecotourism (or nature-based tourism) could be as large as US$ 210×10(12), providing an enormous financial incentive against habitat loss and exploitation. However, is ecotourism the most privately and/or socially valuable use of rainforest land? The question is rarely answered because the relevant data, estimates of profits and fixed costs, are rarely available. We present a social cost-benefit analysis of land use in an ecotourism cluster in the Tambopata region of Amazonian Peru. The net present value of ecotourism-controlled land is given by the producer surplus (profits plus fixed costs of ecotourism lodges): US$ 1,158 ha(-1), which is higher than all currently practiced alternatives, including unsustainable logging, ranching, and agriculture. To our knowledge, this is the first sector-wide study of profitability and producer surplus in a developing-country ecotourism sector and the first to compare against equivalent measures for a spectrum of alternative uses. We also find that ecotourism-controlled land sequesters between 5.3 to 8.7 million tons of above-ground carbon, which is equivalent to between 3000-5000 years of carbon emissions from the domestic component of air and surface travel between the gateway city of Cusco and the lodges, at 2005 emission rates. Ecotourism in Tambopata has successfully monetized the hedonic value of wild nature in Amazonian Peru, and justifies the maintenance of intact rainforest over all alternative uses on narrow economic grounds alone.

  16. Photoacoustic, Photothermal, and Diffusion-Wave Sciences in the Twenty-First Century: Triumphs of the Past Set the Trends for the Future

    NASA Astrophysics Data System (ADS)

    Mandelis, Andreas

    2012-11-01

    A handful of early breakthroughs in photoacoustic science and engineering since its modern-day (scientific) renaissance in the 1970s has defined directions in the development of the photoacoustic, photothermal, and diffusion-wave fields in the past 40 years that have shaped modern day developments and have led to an impressive range of vibrant and unique technologies in the third millennium (technological renaissance). A power-point presentation on the ICPPP-16 opening plenary talk focuses on the historical roots of what I perceive to be some of today's most successful and unique technologies, while readily acknowledging the impossibility to be all inclusive. It can be found under the url: http://cadift.mie.utoronto.ca/History_of_Photoacoustics-Photothermics.ppt. The thematic areas in question include historical reviews selected among the following topics: Piezoelectric photoacoustic microscopy (PAM) which, along with early gas-phase PA spectroscopic studies of biomaterials such as blood haemoglobin and progress in the physics of photon diffusion waves, has led to the modern-day explosion in biomedical photoacoustic imaging technologies with future trends for photoacoustic and ultrasound co-registered imagers; Thermoreflectance, piezoelectric, and gas-phase PA imaging of semiconductors which, along with developments in photocarrier diffusion wave physics, led to photocarrier radiometry, nanolayer diagnostics, carrierographic imaging of optoelectronic materials, and devices with industrial trends in solar cell inspection and control; Photoacoustic gas-phase and infrared radiometric probing and scanning imaging NDE which led to lock-in thermography and have spawned industrial and biomedical technologies; Thermal-wave interferometry and the quest for thermal coherence which led to thermal-wave cavities, the thermal-wave radar, and derivative depth profiling technologies, and, very recently, thermal coherence tomography. This review is meant to be a growing public record of work in progress, with new materials in the given thematic areas and other thematic areas being added as more information on the rich history of the field becomes available. Direct inputs to the author by the broader photoacoustic, photothermal, and diffusion-wave community are solicited and strongly encouraged to ensure that all landmark and seminal work that shaped the state of the science and art in the field receives fair and deserving exposure and the historical review becomes truly representative and comprehensive.

  17. What can triumphs and tribulations from Alzheimer’s disease drug research tell us about the development of psychotropic drugs in general?

    PubMed Central

    Becker, Robert E.; Seeman, Mary V.; Greig, Nigel H.; Lahiri, Debomoy K

    2016-01-01

    Summary Drug development for psychiatric disorders has virtually ground to a halt. Some recent drugs are better tolerated and others safer than earlier ones, but they are no more effective. Years of failure in preventing or delaying onset of illness, in ameliorating symptoms, in lowering suicide rates, in improving quality of life, have put at risk the commercial investments that have, in the past, funded the various stages of drug development. To promote the development of drugs with greater efficacy, psychiatry needs to improve the way it brings potentially helpful drugs to market. Psychiatry needs to learn from other fields that human beings differ in their response to drugs. Psychiatric drug research needs to be grounded in a better understanding of molecular brain mechanisms, neural circuits, and their relationships to clinical diseases. Using this understanding, drugs need to be more precisely directed at specific brain targets. In psychiatric drug development, government, industry, regulators and academia must realign to meet medicine’s responsibilities and use science in the best interests of patients. PMID:26249306

  18. Hale’s Handful Up from the Ashes. The Forging of the Seventh Air Force from the Ashes of Pearl Harbor to the Triumph of VJ-day

    DTIC Science & Technology

    2002-07-01

    consisting of a seven thousand foot runway (with steel matting), dispersal ability for 78 fighters and 24 heavy bombers, and third-level maintenance...to Seventh Air Force P-47s and Navy TBF Avengers, Sev- enth Air Force B-25s were given a rare opportunity in the Central Pacific to fly missions for...artillery gunfire was halted for an hour as 125 P-47s, B-25s, and TBFs pounded the restricted area with 69 tons of bombs. 126 Prisoners of war later

  19. The Market Triumph of Ecotourism: An Economic Investigation of the Private and Social Benefits of Competing Land Uses in the Peruvian Amazon

    PubMed Central

    Kirkby, Christopher A.; Giudice-Granados, Renzo; Day, Brett; Turner, Kerry; Velarde-Andrade, Luz Marina; Dueñas-Dueñas, Agusto; Lara-Rivas, Juan Carlos; Yu, Douglas W.

    2010-01-01

    Annual revenue flow to developing countries for ecotourism (or nature-based tourism) could be as large as US$ 210×1012, providing an enormous financial incentive against habitat loss and exploitation. However, is ecotourism the most privately and/or socially valuable use of rainforest land? The question is rarely answered because the relevant data, estimates of profits and fixed costs, are rarely available. We present a social cost-benefit analysis of land use in an ecotourism cluster in the Tambopata region of Amazonian Peru. The net present value of ecotourism-controlled land is given by the producer surplus (profits plus fixed costs of ecotourism lodges): US$ 1,158 ha−1, which is higher than all currently practiced alternatives, including unsustainable logging, ranching, and agriculture. To our knowledge, this is the first sector-wide study of profitability and producer surplus in a developing-country ecotourism sector and the first to compare against equivalent measures for a spectrum of alternative uses. We also find that ecotourism-controlled land sequesters between 5.3 to 8.7 million tons of above-ground carbon, which is equivalent to between 3000–5000 years of carbon emissions from the domestic component of air and surface travel between the gateway city of Cusco and the lodges, at 2005 emission rates. Ecotourism in Tambopata has successfully monetized the hedonic value of wild nature in Amazonian Peru, and justifies the maintenance of intact rainforest over all alternative uses on narrow economic grounds alone. PMID:20927377

  20. Triumphs Show: What Makes Art History? Year 7 Exploit the Resources of the Victoria and Albert Museum's Medieval Gallery to Create and Curate Their Own Answer

    ERIC Educational Resources Information Center

    Copsey, Sarah

    2014-01-01

    What do 14 Year 7 students, an art teacher, a history teacher and the Victoria and Albert Museum have in common? They are all part of the "Stronger Together" Museum Champion project run by The Langley Academy and the River & Rowing Museum and supported by Arts Council England, designed to engage students, teachers and museum staff…

  1. After the triumph of cardiovascular medicine over acute myocardial infarction at the end of the 20th Century. -Can we predict the onset of acute coronary syndrome? (Con)-.

    PubMed

    Kihara, Yasuki

    2011-01-01

    Predicting acute cardiovascular ischemic events is a crucial and urgent issue in the current cardiovascular field. An enormous effort to develop methodologies to achieve this purpose is being undertaken in cardiovascular institutes worldwide. However, currently, there is no established method of determining acute cardiovascular ischemic events in advance. This article reviews the latest progress on understanding how these events occur and how they can be detected. This goal represents a great dream that has realistic expectations.

  2. Magnetization Reversal and Magnetic Anisotropy of Fe, Ni and Co Nanowires in Nanoporous Alumina Membranes

    DTIC Science & Technology

    2001-04-01

    anisotropy, which is well-known for hcp -Co with an easy axis perpendicular to the long axis of the wire, can be found in pores with a rather large...predominates. In smaller pores hcp -Co is substituted bit by bit by fcc-Co which does not show a significant magnetocrystalline anisotropy. Therefore, Co wires...wires a mixture of fcc-Co and hcp -Co can be found. The amount of fcc-Co increases if the pore diameter decreases [1,2]. Fcc-Co, however, does not show

  3. Binary tree-based low power state assignment algorithm

    NASA Astrophysics Data System (ADS)

    Kajstura, Krzysztof; Kania, Dariusz

    2016-12-01

    A new low power state assignment algorithm is proposed in this paper. The essence of new coding is dividing all the states into subsets, which are sequentially assigned to the individual bits of code. This type of decomposition encoding, in which the coding is done bit by bit, retains the flexibility of assigning code words from the beginning to the end of the encoding process. The results of the experiments confirm efficiency of the proposed algorithm in comparison with the state assignment algorithms that have already been developed.

  4. Bit error rate measurement above and below bit rate tracking threshold

    NASA Technical Reports Server (NTRS)

    Kobayaski, H. S.; Fowler, J.; Kurple, W. (Inventor)

    1978-01-01

    Bit error rate is measured by sending a pseudo-random noise (PRN) code test signal simulating digital data through digital equipment to be tested. An incoming signal representing the response of the equipment being tested, together with any added noise, is received and tracked by being compared with a locally generated PRN code. Once the locally generated PRN code matches the incoming signal a tracking lock is obtained. The incoming signal is then integrated and compared bit-by-bit against the locally generated PRN code and differences between bits being compared are counted as bit errors.

  5. Satellite communications application to Pacific countries above Ku band

    NASA Astrophysics Data System (ADS)

    Iida, Takashi

    1992-08-01

    An application of satellite communications above the Ku band to the Pacific region is described, focusing on: (1) Lightsat system and (2) a high capacity satellite system. A small geostationary satellite system using Ku band for the Federated States of Micronesia is shown as an example. A concept of multi-gigabits/second high capacity communications system using two satellites in the Ka band is described. The onboard bit-by-bit processing is very useful in the low link margin environment due to rain attenuation. These topics were obtained by the Asia Pacific Telecommunications Study granted by NASA conducted by the University of Colorado at Boulder.

  6. Method of parallel switching of optical channels

    SciTech Connect

    Kompanets, I N; Neevina, T A; Kompanets, S I

    2012-12-31

    The possibility of creating parallel-type switches for N Multiplication-Sign N optical waveguide channel communication is studied. A method based on bit-by-bit channel addressing is proposed and one of its possible implementations using the photorefractive effect in the waveguide material is considered. The method is modelled by the example of switching of 8 Multiplication-Sign 8 channels, controlled by reconfigurable matrix of light signals. (special issue devoted to the 90th anniversary of n.g. basov)

  7. Satellite communications application to Pacific countries above Ku band

    NASA Technical Reports Server (NTRS)

    Iida, Takashi

    1992-01-01

    An application of satellite communications above the Ku band to the Pacific region is described, focusing on: (1) Lightsat system and (2) a high capacity satellite system. A small geostationary satellite system using Ku band for the Federated States of Micronesia is shown as an example. A concept of multi-gigabits/second high capacity communications system using two satellites in the Ka band is described. The onboard bit-by-bit processing is very useful in the low link margin environment due to rain attenuation. These topics were obtained by the Asia Pacific Telecommunications Study granted by NASA conducted by the University of Colorado at Boulder.

  8. Non-Earth-centric life detection

    NASA Technical Reports Server (NTRS)

    Conrad, P. G.; Nealson, K. H.

    2000-01-01

    Our hope is that life will, bit by bit, reveal the clues that will allow us to piece together enough evidence to recognize it whenever and however it presents itself. Indisputable evidence is measurable, statistically meaningful and independent of the nature of the life it defines. That the evidence for life be measurable is a fundamental requirement of the scientific method, as is the requirement for statistical significance, and this quantitation is what enables us to differentiate the measurable criteria of candidate biosignatures from a background (host environment).

  9. Screening for Specific Phobias

    MedlinePlus

    ... Anxiety FAQs Screen Yourself ADAA Online Support Group Personal Stories of Triumph "Triumph" E-News Webinars Blog ... Screening for Posttraumatic Stress Disorder (PTSD) Screening for Social Anxiety ... to fulfill responsibilities with work, school, or family? Yes No placed ...

  10. A 12-bit, 1 MS/s SAR-ADC for a CZT-based multi-channel gamma-ray imager using a new digital calibration method

    NASA Astrophysics Data System (ADS)

    Liu, W.; Wei, T.; Yang, L.; Hu, Y.

    2016-03-01

    The successive approximation register-analog to digital converter (SAR-ADC) is widely used in the CdZnTe-based gamma-ray imager because of its outstanding characteristics of low power consumption, relatively high resolution, and small die size. This study proposes a digital bit-by-bit calibration method using an input ramp signal to further improve the conversion precision and power consumption of an SAR-ADC. The proposed method is based on the sub-radix-2 redundant architecture and the perturbation technique. The proposed calibration algorithm is simpler, more stable, and faster than traditional approaches. The prototype chip of the 12-bit, 1 MS/s radiation-hardened SAR-ADC has been designed and fabricated using the TSMC 0.35 μm 2P4M CMOS process. This SAR-ADC consumes 3 mW power and occupies a core area of 856× 802μm2. The digital bit-by-bit calibration algorithm is implemented via MATLAB for testing flexibility. The effective number of bits for this digitally calibrated SAR-ADC reaches 11.77 bits. The converter exhibits high conversion precision, low power consumption, and radiation-hardened design. Therefore, this SAR-ADC is suitable for multi-channel gamma-ray imager applications.

  11. A new paradigm for reproducing and analyzing N-body simulations of planetary systems

    NASA Astrophysics Data System (ADS)

    Rein, Hanno; Tamayo, Daniel

    2017-01-01

    The reproducibility of experiments is one of the main principles of the scientific method. However, numerical N-body experiments, especially those of planetary systems, are currently not reproducible. In the most optimistic scenario, they can only be replicated in an approximate or statistical sense. Even if authors share their full source code and initial conditions, differences in compilers, libraries, operating systems or hardware often lead to qualitatively different results. We provide a new set of easy-to-use, open-source tools that address the above issues, allowing for exact (bit-by-bit) reproducibility of N-body experiments. In addition to generating completely reproducible integrations, we show that our framework also offers novel and innovative ways to analyze these simulations. As an example, we present a high-accuracy integration of the Solar System spanning 10 Gyrs, requiring several weeks to run on a modern CPU. In our framework we can not only easily access simulation data at predefined intervals for which we save snapshots, but at any time during the integration. We achieve this by integrating an on-demand reconstructed simulation forward in time from the nearest snapshot. This allows us to extract arbitrary quantities at any point in the saved simulation exactly (bit-by-bit), and within seconds rather than weeks. We believe that the tools we present in this paper offer a new paradigm for how N-body simulations are run, analyzed, and shared across the community.

  12. Tragedy, transformation, and triumph: comparing the factors and forces that led to the adoption of the 1860 Adulteration Act in England and the 1906 Pure Food and Drug Act in the United States.

    PubMed

    London, Jillian

    2014-01-01

    The 1860 Adulteration Act in England and the 1906 Pure Food and Drug Act in the United States were two of the earliest pieces of legislation to provide generalized regulation of food and drugs on a national scale. While significant scholarly attention has been given to explaining the factors and forces that led to the passage of each Act independent of the other, few books or articles have directly compared the similar individuals and events that led to the adoption of both Acts. This paper attempts to fill that gap. Through a comparative examination, this paper reveals that four main components were key to the national pure food and drug movements in both countries: individuals who crusaded for national adulteration legislation; tragedies that shocked the public into calling for reform; press and publicity that was willing and able to bring the evils of adulteration to the forefront of the public mind; and a transformation of the social, political, and economic systems, which created atmospheres conducive to reform. This paper aims to shed new light on the 1860 Adulteration Act and the 1906 Pure Food and Drug Act--two acts that derive their importance not just from the effect that they directly had on the regulation of food and drugs but also as some of the earliest examples of western governments coming to recognize the need for national regulation to protect the public from harm and coming to embrace their changing role as spearheads of modern regulatory states.

  13. A resolution celebrating the life and achievements of Lena Mary Calhoun Horne and honoring her for her triumphs against racial discrimination and her steadfast commitment to the civil rights of all people.

    THOMAS, 111th Congress

    Sen. Gillibrand, Kirsten E. [D-NY

    2010-05-14

    05/14/2010 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S3790-3792; text as passed Senate: CR S3791-3792; text of measure as introduced: CR S3786) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  14. Genetics and Mapping of Seedling Resistance to Ug99 Stem Rust in the Winter Wheat Cultivar Triumph 64 and Differentiation of SrTmp, SrCad, and Sr42

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Stem rust, caused by the fungus Puccinia graminis f. sp. tritici Eriks. & E. Henn. (Pgt), is an important disease of wheat that can be controlled by deploying effective stem rust resistance (Sr) genes. The emergence of virulent Pgt races in Africa, namely Ug99 and its variants, has stimulated the se...

  15. MAC, A System for Automatically IPR Identification, Collection and Distribution

    NASA Astrophysics Data System (ADS)

    Serrão, Carlos

    Controlling Intellectual Property Rights (IPR) in the Digital World is a very hard challenge. The facility to create multiple bit-by-bit identical copies from original IPR works creates the opportunities for digital piracy. One of the most affected industries by this fact is the Music Industry. The Music Industry has supported huge losses during the last few years due to this fact. Moreover, this fact is also affecting the way that music rights collecting and distributing societies are operating to assure a correct music IPR identification, collection and distribution. In this article a system for automating this IPR identification, collection and distribution is presented and described. This system makes usage of advanced automatic audio identification system based on audio fingerprinting technology. This paper will present the details of the system and present a use-case scenario where this system is being used.

  16. More White Supremacy? "The Lord of the Rings" as Pro-American Imperialism

    ERIC Educational Resources Information Center

    Knaus, Christopher

    2005-01-01

    "The Lord of the Rings" continues Hollywood's recurrent theme of good triumphing over evil. The viewer is supposed to identify with the heroes, whiteness, and goodness, which of course triumphs over evil and blackness. Although the cast is made up almost entirely of White people, people also do not question this narrative of White supremacy. To…

  17. Churchill, The Victorian Man of Action

    DTIC Science & Technology

    1993-01-01

    such heroes as Bulldog Drum- mond and Major-General Richard Hannay. And in 1917, Conan Doyle ended His Last Bow, the final volume of Sherlock Holmes...60. Winston S. Churchill, The Second World War, Vol 6, Triumph and Tragedy (Boston: Houghton Mifflin, 1953), p. 15. 61. Arthur Bryant, Triumph in

  18. Stealing Innocence: Youth, Corporate Power, and the Politics of Culture.

    ERIC Educational Resources Information Center

    Giroux, Henry A.

    This book looks at the way corporate cultures is encroaching on children's lives. It explores three myths prevalent in society: (1) that the triumph of democracy is equal to the triumph of the market; (2) that children are unaffected by power and politics; and (3) that teaching and learning are no longer linked to improving the world. The book…

  19. What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of:“All that is necessary for the triumph of evil is that good men do nothing?”

    PubMed Central

    Triggle, Chris R; Triggle, David J

    2007-01-01

    Peer review is an essential component of the process that is universally applied prior to the acceptance of a manuscript, grant or other scholarly work. Most of us willingly accept the responsibilities that come with being a reviewer but how comfortable are we with the process? Peer review is open to abuse but how should it be policed and can it be improved? A bad peer review process can inadvertently ruin an individual’s career, but are there penalties for policing a reviewer who deliberately sabotages a manuscript or grant? Science has received an increasingly tainted name because of recent high profile cases of alleged scientific misconduct. Once considered the results of work stress or a temporary mental health problem, scientific misconduct is increasingly being reported and proved to be a repeat offence. How should scientific misconduct be handled—is it a criminal offence and subject to national or international law? Similarly plagiarism is an ever-increasing concern whether at the level of the student or a university president. Are the existing laws tough enough? These issues, with appropriate examples, are dealt with in this review. PMID:17583174

  20. What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of: "all that is necessary for the triumph of evil is that good men do nothing"?

    PubMed

    Triggle, Chris R; Triggle, David J

    2007-01-01

    Peer review is an essential component of the process that is universally applied prior to the acceptance of a manuscript, grant or other scholarly work. Most of us willingly accept the responsibilities that come with being a reviewer but how comfortable are we with the process? Peer review is open to abuse but how should it be policed and can it be improved? A bad peer review process can inadvertently ruin an individual's career, but are there penalties for policing a reviewer who deliberately sabotages a manuscript or grant? Science has received an increasingly tainted name because of recent high profile cases of alleged scientific misconduct. Once considered the results of work stress or a temporary mental health problem, scientific misconduct is increasingly being reported and proved to be a repeat offence. How should scientific misconduct be handled--is it a criminal offence and subject to national or international law? Similarly plagiarism is an ever-increasing concern whether at the level of the student or a university president. Are the existing laws tough enough? These issues, with appropriate examples, are dealt with in this review.

  1. Standing Up for Scope.

    PubMed

    Berlin, Joey

    2017-01-01

    The Texas Medical Association triumphed when a Travis County district court sided with medicine in a lawsuit against the Texas Board of Chiropractic Examiners over its granting chiropractors the authority to perform certain diagnostic tests.

  2. Axiomatics of Geometry in School and in Science.

    ERIC Educational Resources Information Center

    Zeitler, Herbert

    1990-01-01

    Geometric axioms are discussed in terms of philosophy, history, refinements, and basic concepts. The triumphs and limitations of the formalism theory are included. Described is the status of high school geometry internationally. (KR)

  3. A Leader in Clinical Trials, Medical Data, & Electronic Health Information | NIH MedlinePlus the Magazine

    MedlinePlus

    ... system so that the miraculous triumphs of modern science can be taken from the laboratory to all ... Photo courtesy of Profiles in Science Profiles in Science The Profiles in Science Web site ( www.profiles. ...

  4. Research Issues Underlying the Four-Lab Study: Integrated Disinfection Byproducts Mixtures Research

    EPA Science Inventory

    Chemical disinfection of drinking water is a major public health triumph of the 20th century, resulting in significant decreases in morbidity and mortality from waterborne diseases. Disinfection byproducts (DBPs) are chemicals formed by the reaction of oxidizing disinfectants wi...

  5. Harriet Tubman and the Underground Railroad: A Drama Workshop for Junior High and High School Students.

    ERIC Educational Resources Information Center

    Tabone, Carmine; Albrecht, Robert

    2000-01-01

    Claims drama in the classroom offers teachers an opportunity to "bring to life" the challenges and triumphs of African Americans. Describes a drama workshop based on the story of Harriet Tubman and the Underground Railroad. (NH)

  6. 3 CFR 8534 - Proclamation 8534 of June 10, 2010. King Kamehameha Day, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... culture. The Hawaiian narrative is one of both profound triumph and, sadly, deep injustice. It is the... opportunities we all have to grow and learn from one another as we carry our Nation toward a brighter day....

  7. Biological neural networks as model systems for designing future parallel processing computers

    NASA Technical Reports Server (NTRS)

    Ross, Muriel D.

    1991-01-01

    One of the more interesting debates of the present day centers on whether human intelligence can be simulated by computer. The author works under the premise that neurons individually are not smart at all. Rather, they are physical units which are impinged upon continuously by other matter that influences the direction of voltage shifts across the units membranes. It is only the action of a great many neurons, billions in the case of the human nervous system, that intelligent behavior emerges. What is required to understand even the simplest neural system is painstaking analysis, bit by bit, of the architecture and the physiological functioning of its various parts. The biological neural network studied, the vestibular utricular and saccular maculas of the inner ear, are among the most simple of the mammalian neural networks to understand and model. While there is still a long way to go to understand even this most simple neural network in sufficient detail for extrapolation to computers and robots, a start was made. Moreover, the insights obtained and the technologies developed help advance the understanding of the more complex neural networks that underlie human intelligence.

  8. Maximum-Entropy Inference with a Programmable Annealer

    PubMed Central

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A.

    2016-01-01

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition. PMID:26936311

  9. Ultra-Fast Timing and the Application of High Energy Physics Technologies to Biomedical Imaging

    NASA Astrophysics Data System (ADS)

    Chen, Chin-Tu; Kao, Chien-Min; Xie, Quigguo; Frisch, Henry; Heinz, Mary; Sanders, Harold; Tang, Fukung; Anderson, John; Byrum, Karen; Drake, Gary; Heartly, Camden; Le Dû, Patrick; Royon, Christophe; Genat, Jean François; Va'Vra, Jerry

    2008-06-01

    We propose to apply the ultra fast Time Of Flight technique (TOF) developed for High Energy Physics (HEP) particle detectors to biomedical imaging. The similarity of the problem in the two fields as well as the remarkable opportunities in biomedical imaging to use technologies developed in HEP have the potential to make major advances in the medical world, in particular for Positron Emission Tomography (PET). We will describe and present some preliminary results of the development of a new complete read-out chain able to manage signals from various types of modern photo detectors (MCP, APD, SiPM). This innovative architecture is made of a fast front-end electronics ASIC with novel Digital Signal Processing (DSP) concepts able to reach the Pico-second timing resolution, a time-to-digital converter, a pipelined digital readout and an integrated trigger/filter with real-time data treatment and display. In parallel with the hardware development, we have begun a systematic program to simulate system characteristics from the initial particle interaction to the final digital data, including a bit-by-bit mapping of the front end/data acquisition system. The introduction of these techniques and tools, common in HEP, has the potential to make improvement to biomedical imaging systems.

  10. Fully Exploiting the Potential of the Periodic Table through Pattern Recognition

    NASA Astrophysics Data System (ADS)

    Schultz, Emeric

    2005-11-01

    This article describes an approach to learning chemical concepts that uses simple rules and pattern recognition to make the formulas of the oxides and hydrides of selected elements in the periodic table. The concepts that emerge from these exercises include: (i) how and why we write formulas as we do; (ii) the greatest and smallest values for oxidation numbers for important elements; (iii) the electronegativity scale; (iv) the acidic or basic characteristics of oxides depending on the formula and its location in the periodic table. This method involves a step-by-step progression in the student's ability to write formulas and balance equations without requiring a previous knowledge of chemical species or charge. Exceptions discovered in obtaining patterns are used to develop additional concepts as well as to discover regions of the table in which exceptions may be expected. This approach stresses finding commonalities rather than differences. This approach contrasts to current ways of presenting foundational materials in which, subject material is presented without regard to a rational development and in which exceptions abound. The current approach, in the author's opinion, sets the student on the path of learning chemistry bit by bit instead of in a holistic fashion.

  11. Maximum-Entropy Inference with a Programmable Annealer

    NASA Astrophysics Data System (ADS)

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A.

    2016-03-01

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition.

  12. A simulation analysis of phase processing circuitry in the Ohio University Omega receiver prototype

    NASA Technical Reports Server (NTRS)

    Palkovic, R. A.

    1975-01-01

    A FORTRAN IV simulation study of the all-digital phase-processing circuitry is described. A digital phase-lock loop (DPLL) forms the heart of the Omega navigation receiver prototype, and through the DPLL, the phase of the 10.2 KHz Omega signal was estimated when the true signal phase is contaminated with noise. The DPLL uses a frequency synthesizer as the reference oscillator. The synthesizer is composed of synchronous rate multipliers (SRM's) driven by a temperature-compensated crystal oscillator, and the use of the SRM's in this application introduces phase jitter which degrades system performance. Simulation of the frequency synthesizer discussed was to analyze the circuits on a bit-by-bit level in order to evaluate the overall design, to see easily the effects of proposed design changes prior to actual breadboarding, to determine the optimum integration time for the DPLL in an environment typical of general aviation conditions, and to quantify the phase error introduced by the SRM synthesizer and examine its effect on the system.

  13. Maximum-Entropy Inference with a Programmable Annealer.

    PubMed

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A

    2016-03-03

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition.

  14. Target azimuth estimation for automatic tracking in range-gated imaging

    NASA Astrophysics Data System (ADS)

    Cao, Yinan; Wang, Xinwei; Zhou, Yan

    2012-11-01

    Target tracking is of great importance in imaging system, which can be applied in surveillance, as well as salvage and rescue where 3D spatial coordinates are used to locate the target. Range-gated imaging system is capable of acquiring range information of targets. However, azimuth is also necessary to provide the spatial coordinates to achieve target tracking. This paper presents a target azimuth estimation method for range-gated imaging system, aiming at obtaining essential information for vision-based automatic tracking. Due to the noise and low contrast of range-gated image, median filter and histogram equalization are used. Then the Otsu method is performed to make the segmentation of target and background. After segmentation, morphologic transformation methods will be taken in order to delete false targets. With pixels of target extracted from the image, the centoid will be derived. Next the pinhole camera model is applied to work out the azimuth coordinate. Since the focus length of camera is needed in the formula, an NC (Numerical Control) zoom module is developed. In this module, a sliding potentiometer is connected to the focus motor in camera, which serves as a feedback of the focus. To read the focus length and control the focus motor, an MCU (with AD converter) is used. Once the target azimuth information is obtained, the pan-tilt control unit can track the target bit by bit automatically.

  15. Study report on laser storage and retrieval of image data

    NASA Technical Reports Server (NTRS)

    Becker, C. H.

    1976-01-01

    The theoretical foundation is presented for a system of real-time nonphotographic and nonmagnetic digital laser storage and retrieval of image data. The system utilizes diffraction-limited laser focusing upon thin metal films, melting elementary holes in the metal films in laser focus. The metal films are encapsulated in rotating flexible mylar discs which act as the permanent storage carries. Equal sized holes encompass two dimensional digital ensembles of information bits which are time-sequentially (bit by bit) stored and retrieved. The bits possess the smallest possible size, defined by the Rayleigh criterion of coherent physical optics. Space and time invariant reflective read-out of laser discs with a small laser, provides access to the stored digital information. By eliminating photographic and magnetic data processing, which characterize the previous state of the art, photographic grain, diffusion, and gamma-distortion do not exist. Similarly, magnetic domain structures, magnetic gaps, and magnetic read-out are absent with a digital laser disc system.

  16. A novel optoelectronic serial-to-parallel converter for 25-Gbps burst-mode optical packets.

    PubMed

    Ibrahim, Salah; Ishikawa, Hiroshi; Nakahara, Tatsushi; Takahashi, Ryo

    2014-01-13

    A new optoelectronic serial-to-parallel converter (SPC) has been developed to interface 25-Gbps asynchronous optical packets to CMOS circuitry. Other than all previous optoelectronic SPCs that are limited to single-shot operation and hence that can only be used for packet label processing, the SPC presented here can operate repeatedly with a period of as low as 640 ps to perform 1:16 conversion for an entire burst-mode 25-Gbps optical packet. The new SPC adopts a shared-trigger configuration and hence a single device can either convert a single packet or dual packets simultaneously. In this paper, the design and operation of the new SPC is explained after reviewing the fundamentals of performing bit-by-bit serial-to-parallel conversion by using HEMT-arrays and MSM-PDs. The response of the fabricated SPC device is presented and explained, together with the experimental work done to demonstrate 1:16 dual packet conversion at 25 Gbps.

  17. PolyCheck: Dynamic Verification of Iteration Space Transformations on Affine Programs

    SciTech Connect

    Bao, Wenlei; Krishnamoorthy, Sriram; Pouchet, Louis-noel; Rastello, Fabrice; Sadayappan, Ponnuswamy

    2016-01-11

    High-level compiler transformations, especially loop transformations, are widely recognized as critical optimizations to restructure programs to improve data locality and expose parallelism. Guaranteeing the correctness of program transformations is essential, and to date three main approaches have been developed: proof of equivalence of affine programs, matching the execution traces of programs, and checking bit-by-bit equivalence of the outputs of the programs. Each technique suffers from limitations in either the kind of transformations supported, space complexity, or the sensitivity to the testing dataset. In this paper, we take a novel approach addressing all three limitations to provide an automatic bug checker to verify any iteration reordering transformations on affine programs, including non-affine transformations, with space consumption proportional to the original program data, and robust to arbitrary datasets of a given size. We achieve this by exploiting the structure of affine program control- and data-flow to generate at compile-time lightweight checker code to be executed within the transformed program. Experimental results assess the correctness and effectiveness of our method, and its increased coverage over previous approaches.

  18. Least Reliable Bits Coding (LRBC) for high data rate satellite communications

    NASA Technical Reports Server (NTRS)

    Vanderaar, Mark; Wagner, Paul; Budinger, James

    1992-01-01

    An analysis and discussion of a bandwidth efficient multi-level/multi-stage block coded modulation technique called Least Reliable Bits Coding (LRBC) is presented. LRBC uses simple multi-level component codes that provide increased error protection on increasingly unreliable modulated bits in order to maintain an overall high code rate that increases spectral efficiency. Further, soft-decision multi-stage decoding is used to make decisions on unprotected bits through corrections made on more protected bits. Using analytical expressions and tight performance bounds it is shown that LRBC can achieve increased spectral efficiency and maintain equivalent or better power efficiency compared to that of Binary Phase Shift Keying (BPSK). Bit error rates (BER) vs. channel bit energy with Additive White Gaussian Noise (AWGN) are given for a set of LRB Reed-Solomon (RS) encoded 8PSK modulation formats with an ensemble rate of 8/9. All formats exhibit a spectral efficiency of 2.67 = (log2(8))(8/9) information bps/Hz. Bit by bit coded and uncoded error probabilities with soft-decision information are determined. These are traded with with code rate to determine parameters that achieve good performance. The relative simplicity of Galois field algebra vs. the Viterbi algorithm and the availability of high speed commercial Very Large Scale Integration (VLSI) for block codes indicates that LRBC using block codes is a desirable method for high data rate implementations.

  19. The UNESCO Universal Declaration on Bioethics and Human Rights: protecting future generations and the quest for a global consensus.

    PubMed

    Salako, Solomon E

    2008-12-01

    Since the coining of the term 'ectogenesis' by Haldane in 1924, we have witnessed sensational biotechnological triumphs such as in vitro fertilisation, the cloning of "Dolly" the sheep, and the publication of the human genetic code. These triumphs mix benefits with portents in one seamless package. The object of this article is to assess critically the Universal Declaration on Bioethics and Human Rights. It is argued that the Declaration is not a suitable international instrument for regulating biotechnology and protecting future generations. Finally, the feasibility of a legally binding international instrument based on a global consensus is evaluated.

  20. Polymethylmethacrylate membrane with a series of serendipity.

    PubMed

    Sakai, Yoshitada

    2011-01-01

    Forty years have passed since the polymethylmethacrylate (PMMA) membrane was first developed. This article reviews its history and explains its longevity. The membrane was developed through application of a stereocomplex phenomenon that is observed upon mixture of isotactic and syndiotactic PMMA polymers. Filtryzer(TM) B1 and B2 were approved in Japan in 1977. B1 was the pioneer high-performance membrane model and B2 was a model that simulated a low-flux cellulosic membrane. The development of B1 led to the development of the dialysis machine with an ultrafiltration rate (UFR)-controlling function because the UFR of B1 was too high to control using transmembrane pressure control. B1 was used not only as a dialyzer but also as a hemodiafilter by combination with a UFR controller. Biocompatibility of the dialysis membrane, complement activation and/or transient leukopenia was studied with B2. Cooperative studies between Niigata University and Toray resulted in Gejyo's finding regarding the harmfulness of β(2)-microglobulin (BMG). Long-term follow-up of patients dialyzed using the BK membrane revealed that plasma BMG levels were significantly low and that the occurrence ratio of carpal tunnel syndrome was suppressed. These results were obtained by the adsorptive removal of BMG onto a PMMA membrane. Several papers have discussed new aspects in succession mainly based on clinical experiences that were not aimed at a development stage, i.e. they were kinds of serendipity. For the BK-F membrane with the largest pore size, this includes anemia and removal or modification of furancarboxylic acid, homocysteine, pentosidine and soluble CD40. For the BG membrane with a slightly anionic component, this includes pruritus and removal of free immunoglobulin light chains. Even patients' prognoses may be modified by the use of PMMA membrane. The mechanisms of these findings have been clarified bit by bit and the membrane will further open new frontiers in dialysis treatment.

  1. Flow Redistribution Between Legs and Brain During STS 93 Re-Entry and Landing

    NASA Technical Reports Server (NTRS)

    Arbeille, P.; Meck, J.; Porcher, M.; Benavides, E.; Martin, D. S.; South, D. A.; Ribeiro, C.; Westover, A.

    2003-01-01

    The objective was to quantify bit by bit the arterial hemodynamic response to the successive acceleration induced fluid shifts during re-entry and landing. Method: The astronaut instrumented himself with a flat Doppler probe fixed on the skin, a blood pressure arm cuff, and 3 ECG electrodes. The ICMS (integrated cardiovascular monitoring system, 15x15x25 cu cm, battery powered) designed to monitor Blood pressure, ECG, cerebral and femoral flows was fixed below the astronaut sit in the middeck. Recordings started 5 minutes before de-orbiting (TIG) and stopped 5 min after wheels stop. Results. During re-entry blood pressure increased by 20% at TIG, and then by 25 to 30% during the highest Gz accelerations (approx 1 S g ) . The cerebral flow remained decreased by 10 to 15% below inflight value all during the Entry and landing phases. Conversely the femoral flow increased at TIG and entry ( + l0 to 20%), recovered at 0.lg, and then decreased in proportion with the Gz acceleration (-10% to -40% from 0.5g to 1.5g). The reduction in Femoral flow was associated with an opposite variation in lower limb vascular resistance. Consequently the cerebral flow/femoral flow ratio decreased at TIG and entry (-20%), and then increased according to the Gz acceleration level ( + l0 to +40% from 0.5 to 1.5g). Conclusion: During orthostatic tests (Stand LBNP tests) the cerebral to femoral flow ratio allowed to quantify the efficiency of the flow redistribution between these 2 areas and predicted orthostatic intolerance. In the present case the astronaut was found orthostatically tolerant at postflight tilt tests, but we suggest that during re-entry this parameter could predict the occurrence of syncope in severely disadapted astronauts.

  2. Wavelength techniques for digital holographic memories

    NASA Astrophysics Data System (ADS)

    Lande, David

    Holographic storage is a technique to store and retrieve information spread out in a volume, in contrast to current optical devices which store information locally on a surface. It provides for parallel page-by-page recording and readout of data instead of the usual serial, bit-by-bit, technique, and offers much higher diffraction-limited capacity. Success in the development of a competitive holographic storage device then depends on its cost, compactness and reliability. Since the first digital demonstrations, considerable effort by various groups has been spent in the development of high performance, practical holographic systems. This thesis presents several contributions toward this goal, suitable for holographic storage in lithium niobate and other applicable media. An intuitive explanation of volume holography is given, and Fourier analysis is used to derive the diffraction- limited capacity of digital storage in the form of elementary refractive index gratings. The physics of photorefractive materials, which are commonly used in holographic recording, is then presented, along with an established phenomenological model for grating formation. Following an analysis of imaging and multiplexing, a completely automated storage system implementing wavelength-multiplexed holography is described and evaluated, highlighting the feasibility of systems with fewer optical and mechanical components. The volatility of information in photorefractive media is then addressed by a demonstration of optical fixing, a technique based on two-photon recording mechanisms. Such an all-optical technique removes the need for heating elements, high voltages, or other post-processing elements currently used in non-volatile systems. Two-photon recording is also used to modulate, or apodize, the amplitude of volume gratings within the crystal bulk, providing a flexible technique to reduce cross-talk noise between stored pages and optimize the system capacity. Finally, simulations of

  3. RSFQ logic devices; non-linear properties and experimental investigations

    NASA Astrophysics Data System (ADS)

    Mygind, Jesper

    1998-05-01

    Rapid Single Flux Quantum (RSFQ) logic has a great potential as fast digital and high frequency analog electronics. Several Logic/Memory base elements and integrated sub-systems in the RSFQ family have been devised and tested since the pioneering work in the mid 1980s by K. K. Likharev's group at Moscow State University [1,2]. It is argumented why the RSFQ digital circuits are superior to the voltage state family circuits, which were utilised in the first development of Josephson logic. Also the parameter space for operation of the 1-D RSFQ transmission line is discussed. Presently most RSFQ circuits are made with low-Tc superconductors using the now mature whole-wafer NbAlOxNb technology, which allows for large and densely packed integrated circuits. Recently, a few operational high-Tc RSFQ circuits have been reported. An important development within the last two years is the advent of general-purpose on-chip bit-by-bit verification test systems. Timing of RSFQ circuits and a few recent RSFQ "highlights" are briefly mentioned. Basically the RSFQ technology appears "ready" for widespread industrial use. One of the key components is the RSFQ transmission line, which can both generate and transmit SFQ pulses. In order to demonstrate the importance of the fluxon dynamics we discuss a new phenomenon observed in a parallel array of identical junctions. Steps with extremely low differential resistance in the I-V characteristic are found to be due to the self-induced magnetic field produced by the edge current fed to the array. The underlying mechanism is that the nonuniform field divides the moving fluxon into "domains" covering several (unit) cells. The experimental/numerical results illustrate practical and may be more fundamental limits to RSFQ electronics.

  4. [Population education].

    PubMed

    Niang, M

    1992-12-01

    Africa has the highest population growth rate in the world (3%). It has 650 million people (about 900 million in 2000). Rapid population growth has serious consequences which, if not addressed, will be disastrous. This worrisome situation has led some governments to adopt demographic policies to slow down population growth. The UN Economic, Scientific and Cultural Organization (UNESCO) recommends that schools provide population education. Various population conferences have popularized population education in schools among African countries. UNESCO began its regional program on population education in Africa in 1969. National family life and population education (FL/PE) projects have increased from 4 in 1970 to 32 in 1990 (17 in French- and Portuguese-speaking Africa and 5 in English-speaking Africa). These projects teach students about the links between demographic problems and socioeconomic factors and contemporary culture. They aim for total development of the individual and improvement of the quality of life for the individual, family, and community. Topics covered in FL/PE are birth rate; fertility; health; and maternal, infant, and child mortality; unwanted pregnancy; illegal abortion; sexually transmitted diseases; rural-urban migration; and urbanization. Benin introduced FL/PE at all levels of its education system while Senegal, Guinea, Mauritania, and Zaire introduced it to only the primary and secondary school levels. Some countries teach FL/PE as one discipline while most countries (e.g., Senegal) have integrated it into other disciplines (e.g., geography). FL/PE should begin in primary schools because they have the most students and prepare students for middle schools, which provide FL/PE. Elementary education in Senegal is being overhauled to introduce current major problems bit by bit. Senegal also wants to incorporate FL/PE into literacy and adult education programs. Integration of FL/PE into other disciplines should be encouraged.

  5. Classic and Modern Propaganda in Documentary Film: Teaching the Psychology of Persuasion

    ERIC Educational Resources Information Center

    Simpson, Kevin E.

    2008-01-01

    Primary source material found in documentary film has the potential to richly inform college teaching. This article describes using 2 historically significant documentary-style films to teach concepts in the psychology of persuasion. Exemplary clips taken from "Triumph of the Will" (Riefenstahl, 1935) and "Fahrenheit 9/11" (Moore, 2004)…

  6. Understanding Propaganda: The Epistemic Merit Model and its Application to Art

    ERIC Educational Resources Information Center

    Ross, Sheryl Tuttle

    2002-01-01

    Pablo Picasso's "Guernica," Francisco de Goya's "Fifth of May," Eugene Delacroix's "Liberty Leading the People," George Orwell's "Road to Wigan Pier," Leni Riefenstahl's "Triumph of the Will," and D. W. Griffith's "Birth of a Nation," are all examples of expressly political art. Historically some art has been not only an object of aesthetic…

  7. The Best of the Literacy Beat 1988-1989. The Best of the Literacy Beat 1987.

    ERIC Educational Resources Information Center

    Education Writers Association, Washington, DC.

    This document is a set of two volumes that contain prize-winning newspaper articles and summaries of radio and television shows selected as part of the Media Resource Project on Literacy. Items in the 1988-89 book include the following: "Why Daddy Can't Read" (Sally L. Gilman); "The Triumph of Jimmy Sanchez" (Sandra Macias); "Illiteracy:…

  8. God's Turnstile: The Work of John Wheeler and Stephen Hawking.

    ERIC Educational Resources Information Center

    Overbye, Dennis

    1991-01-01

    Presents an excerpt from the book entitled "Lonely Hearts of the Cosmos." Provides narration of behind-the-scenes events in the lives, the scientific debates, and the intellectual triumphs of the two physicists responsible for inventing the concept of the black hole. (JJK)

  9. Vaccination Policies Fall on Schools' Shoulders

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2007-01-01

    Vaccines are one of the triumphs of modern medicine, relegating many once-fearsome diseases to the history books. Denying access to school has long been the best way to ensure that children get vaccinated, but carrying out any change in immunization policy means a lot of work for school officials. This article discusses the unity of several…

  10. What Gets a Cell Excited? Kinky Curves

    ERIC Educational Resources Information Center

    Kay, Alan R.

    2014-01-01

    Hodgkin and Huxley's (5) revealing the origins of cellular excitability is one of the great triumphs of physiology. In an extraordinarily deft series of papers, they were able to measure the essential electrical characteristics of neurons and synthesize them into a quantitative model that accounts for the excitability of neurons and other…

  11. The Power of Four (the 4-Lab Study): ORD’s Integrated Disinfection By-Products Mixtures Research Project

    EPA Science Inventory

    Chemical disinfection of water, a major public health triumph of the 20th century, has resulted in dramatic decreases in morbidity and mortality from water-borne disease. The intended result of chemical disinfection of drinking water is reduction of microbial contamination; the u...

  12. Women as Leaders in Education: Succeeding Despite Inequity, Discrimination, and Other Challenges. Women and Careers in Management

    ERIC Educational Resources Information Center

    Martin, Jennifer L., Ed.

    2011-01-01

    This up-to-date, candid examination of women's careers in education and leadership in education describes the pitfalls, triumphs, and future promise of female leaders in education. Despite the gains women have made in higher education over the past few decades, and an increasing number of well-qualified female candidates, they are still…

  13. The "Saggi" and Practical Work

    ERIC Educational Resources Information Center

    Melville, Wayne

    2013-01-01

    The "Saggi di naturali esperienze" was published in 1667 by one of the earliest scientific societies, the Accademia del Cimento. The book was a triumph for the ruling Medici family of Florence, and the commitment of the Accademia to experimentation helped the "Saggi" become the "laboratory manual" of the 18th century.…

  14. Into the Community and Not on the Shelf: Learning to Develop a Meaningful HIV/AIDS Curriculum for Multiple Communities

    ERIC Educational Resources Information Center

    Riley, Tasha

    2014-01-01

    This paper describes the process involved in creating a community-based training curriculum designed to build capacity and foster new knowledge in support of HIV/AIDS education. Highlighted are the challenges and triumphs incurred while working with community and academic partners to ensure the production of an adaptable curriculum designed to…

  15. 3 CFR 8466 - Proclamation 8466 of December 16, 2009. Wright Brothers Day, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... December 16, 2009 Proc. 8466 Wright Brothers Day, 2009By the President of the United States of America A... Carolina, lifting two brothers from Dayton, Ohio, to their place in history. Their singular triumph... America, do hereby proclaim December 17, 2009, as Wright Brothers Day. IN WITNESS WHEREOF, I have...

  16. The Operational Planning Factors of Culture and Religion

    DTIC Science & Technology

    2007-11-02

    Yugoslavian Inferno , (New York: Continuum Publishing Company, 1994), 229. 33 Ralph Peters, Fighting for the Futures: Will America Triumph...Strategic Studies Institute, U. S. Army War College, 1998. Mojzes, Paul, Yugoslavian Inferno , New York: Continuum Publishing, 1994. Nardin, Terry, The

  17. Early Entrance to College: Students' Stories.

    ERIC Educational Resources Information Center

    Olszewski-Kubilius, Paula

    1998-01-01

    Presents essays that describe the fears, anxieties, hopes, problems, and triumphs of 11 students who chose to go to college early. Difficulties faced included initial academic failures due to immaturity and a lack of well-developed study skills; however, overall achievement was high and the experience was perceived as positive. (CR)

  18. Tom Friedman on Education in the "Flat World"

    ERIC Educational Resources Information Center

    School Administrator, 2008

    2008-01-01

    In his best-selling book, "The World Is Flat," Thomas Friedman describes that the real world is becoming "flat." He describes how 10 forces are "flattening" the 21st century--making it easier for people in India, China and around the world to compete with Americans and others who had triumphed the century before. This article presents an interview…

  19. Overcoming Modern-Postmodern Dichotomies: Some Possible Benefits for the Counselling Profession

    ERIC Educational Resources Information Center

    Bekerman, Zvi; Tatar, Moshe

    2005-01-01

    The rhetorical/discursive turn, in its multiple disciplinary masks, is here to stay. Even psychology is giving in to its charm. The Sophists can smile again, the agora is back, and the solipsistic self is in retreat. Dialogical, narrative, and cultural psychologies, as well as the counselling profession, triumph the return of the social, the…

  20. Toward a Theater of Understanding

    ERIC Educational Resources Information Center

    Silvera, Frank

    1969-01-01

    Praises the humanitarian value of a James Baldwin play, which pleads for compassion and understanding of another man's (here, the Negro's) point of view, trials and triumphs as a human being, and search to find meaning in the human predicament. (KG)

  1. Universal Newborn Screening and Adverse Medical Outcomes: A Historical Note

    ERIC Educational Resources Information Center

    Brosco, Jeffrey P.; Seider, Michael I.; Dunn, Angela C.

    2006-01-01

    Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and…

  2. "The Brain within Its Groove": Language and Struggling Students

    ERIC Educational Resources Information Center

    De Mers, Kathleen D.

    2010-01-01

    Words are the foundation of literacy. Words can express, in part, the joys, loves, triumphs, and sorrows of life. One person's thoughts, expressed through words, can powerfully influence and inspire audiences or readers and long outlive their author. But not everyone is enamored of words. For some students, words are a kind of torture. For them…

  3. Consuming Prose: The Delectable Rhetoric of Food Writing

    ERIC Educational Resources Information Center

    Bloom, Lynn Z.

    2008-01-01

    Food writing, like cooking, offers control over at least a small slice of an otherwise refractory world. As practiced by writers so good that whether they can cook or not is beside the point, food writing is most often upbeat and nurturing, providing successes and triumphs--modest and major--for readers to feast on, with occasional glimpses of…

  4. Western Hemisphere Conference on Persons with Disabilities. Conference Proceedings (Washington, D.C., March 14-18, 1993) = Conferencia Hemisferica Occidental sobre Personas con Discapacidades. Actas de la Conferencia. (Washington, D.C., 14 al 18 de Marzo de 1993).

    ERIC Educational Resources Information Center

    Kelley, Jerry D., Ed.; And Others

    This document presents the proceedings of a conference which brought together delegates and First Ladies representing western hemisphere nations to address needs and issues affecting people with disabilities in the Americas. It presents the texts of two keynote addresses: "Small Triumphs, Big Victories: A Global View of Persons with…

  5. The Courage of Their Convictions: Empowering Voices of Girls.

    ERIC Educational Resources Information Center

    Will, Katherine

    1994-01-01

    Reviews childhood trauma/abuse experienced by Maya Angelou and discusses how Angelou survived and triumphed over these experiences. Relates Angelou's story to moral developmental theory for women proposed by Carol Gilligan, focusing on Gilligan's metaphor of having a "voice." (NB)

  6. Our "Wild Patience": Our Energetic Deeds, Our Energizing Future. Working Paper No. 158.

    ERIC Educational Resources Information Center

    Stimpson, Catharine R.

    The Wellesley College Center for Research on Women represents a triumph of women's studies. Women's studies have sought a particular ethic, valuing the moral equality of those who seek education and of those who offer it. Women's studies have sought to alter institutions so that they embody such an ethic and to change the consciousness of both…

  7. Car Wrecks, Baseball Caps, and Man-to-Man Defense: The Personal Narratives of Adolescent Males.

    ERIC Educational Resources Information Center

    Tobin, Lad

    1996-01-01

    Scrutinizes the author's response to a seemingly stereotypical male narrative written by a student fitting the disruptive macho male stereotype. Examines how teachers respond to stereotypical male narratives of conquest and individualist triumph, and whether their responses to such essays are not conditioned by their responses to the authors. (TB)

  8. Mass Spectrometry Identification of Toxicologically Important Drinking Water Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Before its widespread use, millions of people died from waterborne diseases. Now, people in developed nations receive quality drinking water every day from their public wate...

  9. Stories from Hopescapes

    ERIC Educational Resources Information Center

    Harris, Violet J.

    2011-01-01

    Author Virginia Hamilton had the gift of creating lyrical phrases that captured the complexities of life. Among her most notable phrase is the idea of the "hopescape," the metaphoric description of the pains and joys, triumphs and defeats, longing, and dreams that make us human. The publication of an edited volume that compiles a sampling of…

  10. It's a Gift: "Ray," "The Incredibles" and Lives of Greatness

    ERIC Educational Resources Information Center

    Beck, Bernard

    2005-01-01

    The American biopic is an expression of distinctively American culture. Its story elements mirror the ideologies of mainstream America. The crucial ingredient in a biopic or a cartoon classic is the triumph of an indomitable struggler in circumstances that crush everyone else. "Ray" is an example of the biopic in its strongest and most affecting…

  11. Violence, Democracy and Education: An Analytical Framework. LCSHD Paper Series.

    ERIC Educational Resources Information Center

    Salmi, Jamil

    How can the triumph of Western liberalism be reconciled with the pictures of chaos, war, crime, terror, and poverty which continue to appear in the daily news? Does violence coexist, in a significant fashion, with capitalism and democracy? What role does education play in this context? In addressing these questions, this paper presents a framework…

  12. USSR Report, Military Affairs, No. 1806.

    DTIC Science & Technology

    1983-10-24

    34There’s not a civilian enterprise in the vicinity where people from our unit would not work. One can see them anywhere—both in the confectionary ...navy is a triumph for the labors of our peo- ple and a product of the selfless efforts of our scientists, designers, engineers and workers. The

  13. Science under duress

    NASA Astrophysics Data System (ADS)

    2016-11-01

    In the first half of the 20th century, devotion to Marx's "one science" contributed to the deaths of millions of ordinary Russians. How this happened is the subject of Stalin and the Scientists: a History of Triumph and Tragedy by Simon Ings.

  14. Get the Federal Government out of Education? That Wasn't the Founding Fathers' Vision

    ERIC Educational Resources Information Center

    Jennings, Jack

    2011-01-01

    With the triumph of Tea Party candidates and other conservatives in 2010, many in the new Congress are pressing to get the federal government out of education. Eliminating or curtailing federal involvement in education would be a wrong-headed, simplistic move for several reasons: (1) It ignores the nation's history; (2) It would erode the state…

  15. "Ternura y tenacidad": "Testimonios" of Latina School Leaders

    ERIC Educational Resources Information Center

    Martinez, Melissa A.; Marquez, Jocabed; Cantú, Yvette; Rocha, Patricia A.

    2016-01-01

    This study utilized "testimonio" as method to unearth the voices of four Latina school leaders from the southern region of the U.S. to shed light on their experiences, including triumphs and struggles, in navigating their career trajectories. The "testimonios" revealed distinctions as well as commonalities among the Latina…

  16. 77 FR 285 - Notice of Proposals To Engage in or To Acquire Companies Engaged in Permissible Nonbanking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... establishment of Triumph CRA Holdings, LLC, Dallas, Texas, as a nonbanking subsidiary in lending activities and... companies listed in this notice have given notice under section 4 of the Bank Holding Company Act (12 U.S.C... securities or assets of a company, including the companies listed below, that engages either directly...

  17. Finnish Higher Education Reforms: Responding to Globalization

    ERIC Educational Resources Information Center

    Tjeldvoll, Arild

    2009-01-01

    The international academic success of Finnish secondary schooling in the Program for International Student Assessment (PISA) and the triumph of the Finnish technology company NOKIA have stimulated national ambitions to improve higher education institutions in Finland. Because secondary schooling and technology in Finland receive world recognition,…

  18. Let Freedom Ring! Bulletin, 1937, No. 32

    ERIC Educational Resources Information Center

    Calhoun, Harold G.; Calhoun, Dorothy; Hatch, Roy W.; Cohen, Philip H.; Schramm, Rudolf

    1937-01-01

    This volume of "Let Freedom Ring!" contains the scripts of the 13 national broadcasts of the radio series of that name presented in the spring of 1937 over the national network of the Columbia Broadcast System. In "Let Freedom Ring!" you will find the courage, the struggle, the triumph of men and women who fought to win and safeguard liberties…

  19. Finding Meaning in PDS Stories

    ERIC Educational Resources Information Center

    Breault, Rick A.

    2010-01-01

    The Professional Development School (PDS) literature is filled with the stuff of good storytelling--archetypes of an ancient profession, struggles of marginalized individuals against powerful structures, personal triumphs, and devotion to a quest. However, much of the writing about PDS experiences that could be considered storytelling tends to…

  20. 76 FR 63807 - Leif Erikson Day, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... historic voyages and celebrate the many ways Nordic-American culture has enriched our Nation. The triumphs... America's next great innovation. To honor Leif Erikson and celebrate our Nordic-American heritage, the... upon all Americans to observe this day with appropriate ceremonies, activities, and programs to...

  1. American Album: 200 Years of Constitutional Democracy. Law in U.S. History. Law in Social Studies Series.

    ERIC Educational Resources Information Center

    Suter, Coral; Croddy, Marshall

    This book explores the lives of people who have shaped the laws and legal system of the United States and describes their impact on the U.S. Constitution. The new government's beginnings are examined in unit 1, through the pitfalls and triumphs of the First Continental Congress. The role of John Marshall, the First Chief Justice of the Supreme…

  2. Bumpy Journeys: A Young Chinese Adolescent's Transitional Schooling across Two Sociocultural Contexts

    ERIC Educational Resources Information Center

    Ma, Wen

    2010-01-01

    This qualitative case study explores one young adolescent's transitional schooling from an American context to a Chinese context. Although the student was bilingual and bicultural, she experiences multiple struggles, triumphs, and dilemmas across the two educational settings. These findings have implications for those adolescents and parents who…

  3. Beyond Learning Literacy at School: One Chinese Adolescent's Educational Journey

    ERIC Educational Resources Information Center

    Ma, Wen

    2009-01-01

    Drawing on a variety of qualitative data, this case study explored one Chinese adolescent's decade-long educational journey at various American schools. The findings reveal academic triumphs, familial conflicts, and developmental dilemmas experienced by the student and the family across different sociocultural spaces. This research has…

  4. Disinfection By-Products and Drinking Water Treatment

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Before its widespread use, millions of people died from waterborne diseases. Now, people in developed nations receive quality drinking water every day from their public wa...

  5. Resilient School Leaders: Strategies for Turning Adversity into Achievement

    ERIC Educational Resources Information Center

    Patterson, Jerry L.; Kelleher, Paul

    2005-01-01

    Getting fired, dealing with bitter disputes, having your competence or integrity challenged--these are experiences that educators have all the time. But what's the difference between educators who triumph over adversity versus those who succumb? Blending sage wisdom and research with real stories from educators, this book introduces you to three…

  6. Democratic Education through the Eyes of the Poor: Appraising the Post-Apartheid Experience

    ERIC Educational Resources Information Center

    Msila, Vuyisile

    2013-01-01

    Arguably, one of the major achievements in the 1990s in South Africa was the final toppling of apartheid government and the triumph of democracy over the unjust and unequal past legislation. Since then schools are some of the institutions that have infused democracy ideals into their policies, curriculum and other aspects of school life. The…

  7. 77 FR 33597 - Great Outdoors Month, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... Documents#0;#0; ] Proclamation 8833 of June 1, 2012 Great Outdoors Month, 2012 By the President of the..., trials, and triumphs. During Great Outdoors Month, we celebrate our long legacy of environmental... Outdoors Month is a time for all Americans to share in the natural splendor of which we are all...

  8. Using the GRAPES OF WRATH in the History Classroom.

    ERIC Educational Resources Information Center

    Mills, Randy

    1987-01-01

    Maintains that literary fiction may be used to enhance students' understanding of an historical period. Demonstrates how Steinbeck's GRAPES OF WRATH may be used to convey the human side of problems, sufferings, and triumphs that the United States experienced during the Great Depression. (JDH)

  9. Early Childhood Development in South Africa--Progress Since the End of Apartheid

    ERIC Educational Resources Information Center

    Atmore, Eric

    2013-01-01

    In April 1994, South Africa held its historic first democratic election. The African National Congress overwhelmingly triumphed and Nelson Mandela became the first president of a free and democratic South Africa. In this review, the situation of South Africa's young children under apartheid and the context of young children in South Africa in 2012…

  10. Yes, No, or Maybe? Transitions in Chilean Society in Pablo Larraín's "No"

    ERIC Educational Resources Information Center

    Howe, Alexis

    2015-01-01

    Pablo Larraín's film "No" (2012) has been widely viewed and reviewed both at home in Chile and internationally. Some reviewers have focused on the film's representation of the triumph of hope and optimism over tyranny. Others have criticized the film's historical inaccuracy, citing a list of details that the film either got wrong or left…

  11. Ayn Rand: Effective Educational Leadership Traits Compared to Selfishness

    ERIC Educational Resources Information Center

    Thompson, Barbara A.; Kritsonis, William Allan

    2009-01-01

    A man's self-interest cannot be determined by blind desires or random whims, feelings, urges, or wishes. His interest must be discovered and achieved by the guidance of rational principles that he chooses for himself. This selfishness is man's way to individual triumph over hardships. It is a virtue. Man must be guided by his own independent…

  12. Liberation Therapeutics: Consciousness Raising as a Problem.

    ERIC Educational Resources Information Center

    Lasch-Quinn, Elisabeth

    2002-01-01

    Questions the content and form of consciousness raising as a mode of purveying knowledge or bringing about change by considering its emergence in the civil rights movement. Examines such books as "Black Rage" (William Grierand Price Cobbs), "Triumph of the Therapeutic" (Philip Reiff), "Where Do We Go From Here: Chaos or…

  13. Reconciling Memories of Internment Camp Experiences During WWII in Children's and Young Adult Literature.

    ERIC Educational Resources Information Center

    Glasgow, Jacqueline N.

    2002-01-01

    Examines the uprooting of Japanese Americans during World War II as portrayed in children's/young adult literature. Discovers the triumph of the spirit of the survivors and replaces suppressed images with empowering ones. Considers stories and narratives in literature as a resource through which readers might shape their understanding of the…

  14. The Next Generation of Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended health ...

  15. The Next Generation of Drinking Water Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended healt...

  16. [Odontology and the beginning of cartesianism (1673--1650) (Rene Descartes)].

    PubMed

    Gysel, C

    1979-01-01

    In the seventeenth century the universities of the Netherlands underwent the influence of Descartes in all the faculties. In medicine three periods can be distinguished: in the first, pathology and therapy are still galenic; the second, by the application of the cartesian method, triumphs in physiology; and the third, corrected by the views of Newton is integrated in a moderate biomechanism.

  17. Rings: Five Passions in World Art. Multicultural Curriculum Handbook.

    ERIC Educational Resources Information Center

    High Museum of Art, Atlanta, GA.

    This curriculum handbook uses a discipline based art education (DBAE) approach, and includes lessons appropriate for use with students in grades 3-12. Five units address themes of universally experienced emotions: love, anguish, awe, triumph, and joy. Art exemplars are draw from among the international cultures represented in the High Museum of…

  18. An Australian Science Curriculum: Competition, Advances and Retreats

    ERIC Educational Resources Information Center

    Aubusson, Peter

    2011-01-01

    Science schooling enjoys high status. Scientific capability is perceived as critical in underpinning economic success in advanced societies. Science achievement, at all levels, has become a global competition in which nations want to be seen to triumph. Governments periodically pay close attention to science education with a view to ensuring it…

  19. Using Autobiography as a Vehicle to Study the Cultural Foundations of Twentieth Century African-American Education

    ERIC Educational Resources Information Center

    Hilton, Louis R., III

    2004-01-01

    In using the autobiographies of African-Americans as a heuristic, educators are provided with a context to view African-American educational history. The autobiographies of African-Americans tell stories of triumph over adversity as also revealed in Melba Beals' autobiography, "Warriors Don't Cry," a recount of the struggle to integrate…

  20. DISINFECTION BYPRODUCTS: THE NEXT GENERATION

    EPA Science Inventory

    Disinfection of drinking water is rightly hailed as a major public health triumph of the 20th Century. Before widespread disinfection of drinking water in the U.S. and Europe, millions of people died from infectious waterborne diseases, such as typhoid and cholera. The microbia...

  1. Teaching Dance to Deaf Students: A Case Study in Cape Coast, Ghana

    ERIC Educational Resources Information Center

    Hampton, Tarin T. D.

    2013-01-01

    This article focuses on the challenges and triumphs of teachers who guide students with visual and auditory impairments to learn about and experience African-based dance as part of a healthy, active lifestyle. The teachers share insights they have gained in developing best practices by capturing the inherent nature of dance as kinesthetic…

  2. Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy

    ERIC Educational Resources Information Center

    Damsen, Silver

    2009-01-01

    My dissertation, "Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy" demonstrates how increased crown authority, and an expanded market combine with the mixed agency of the romantic comedy daughter to further encourage early modern economic growth. The triumph of rebelling daughter over blocking father has…

  3. Murals as Monuments: Students' Ideas about Depictions of Civilization in British Columbia

    ERIC Educational Resources Information Center

    Seixas, Peter; Clark, Penney

    2004-01-01

    Around the world people confront monuments that celebrate historical origins, movements, heroes, and triumphs no longer seen as worthy of celebration. While an analysis of these "lieux de memoire" themselves can reveal historical consciousness, the sites become particularly interesting at the moment when they inspire debate, namely, when…

  4. A Toxicological Perspective on Disinfection ByProducts

    EPA Science Inventory

    Disinfection of water is essential for reduction of microbes harmful to human health and chemical disinfection is considered one of the major public health triumphs of the 20th Century. An unintended consequence of disinfection with oxidizing chemicals is formation of disinfectio...

  5. Unfencing the Range: History, Identity, Property, and Apocalypse in "Lame Deer Seeker of Visions."

    ERIC Educational Resources Information Center

    Sanborn, Geoff

    1990-01-01

    Seemingly chaotic to Western eyes, John Lame Deer's autobiography has a meaningful structure based on Lakota numerology and oral tradition. The book explores conflicts between White and Indian conceptions of identity and property, and sees itself as an instrument in the apocalyptic triumph of Indian spirituality over White greed. (SV)

  6. Liberating the Enlightenment: How a Transformed Relationship with Animals Can Help Us Transcend Modernity

    ERIC Educational Resources Information Center

    Williams, Cassandra D.

    2003-01-01

    The Enlightenment rejection of the Cartesian mechanistic understanding of animals was accompanied by a (re)new(ed) anti-cruelty sentiment. Compassion, however, fell victim to the triumph of reason leading Western culture toward an era of cruelty to animals on an unprecedented scale. What was absent in Enlightenment thought, even among proponents…

  7. Understanding Richard Wright's "Black Boy": A Student Casebook to Issues, Sources, and Historical Documents.

    ERIC Educational Resources Information Center

    Felgar, Robert

    In "Black Boy," Richard Wright triumphs over an ugly, racist world by fashioning an inspiring, powerful, beautiful, and fictionalized autobiography. To help students understand and appreciate his story in the cultural, political, racial, social, and literary contexts of its time, this casebook provides primary historical documents,…

  8. Disinfection By-Products: Formation and Occurrence in Drinking Water

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the twentieth century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended he...

  9. Encountering Mortality: A Decade Later, the Pedagogical Necessity of "Six Feet Under"

    ERIC Educational Resources Information Center

    Petitfils, Brad

    2016-01-01

    In today's society, where the Promethean project of mastering the universe seems to guide the scientific community to its last moment of triumph--human immortality--young people seem to lack curricular opportunities to engage with mortality. This is not surprising, as the legacy of psychology, as far back as the times of Freud and Jung, exposes a…

  10. The Perception of Women Contending for First Place in the Information Technology World: A Qualitative Case Study

    ERIC Educational Resources Information Center

    Claggett, Gwendolyn P.

    2016-01-01

    Gender differences have impacted the leadership IT (information technology) environment for decades. Research continues to study the barriers and triumphs women endure within the technical leadership world. Over the past decade, women have strived ahead by ignoring the gender negativity and taken a permanent position in the IT leadership role. The…

  11. Does Watching Help? In Search of the Theory of Change for Education Monitoring

    ERIC Educational Resources Information Center

    Post, David

    2015-01-01

    In 2015 Education for All (EFA), concludes its 25-year cycle, and the Global Monitoring Report (GMR) publishes its final assessment of triumph and defeat in reaching the six EFA goals. Before the United Nations adopts new Sustainable Development Goals, it is essential to consider the underlying theories of monitoring. This essay addresses two…

  12. Contemporary American Success Stories. Famous People of Asian Ancestry. Volume III. A Mitchell Lane Multicultural Biography Series.

    ERIC Educational Resources Information Center

    Marvis, Barbara J.

    As part of a five-volume series written at a reading level for grades five to six and as a tribute to the contributions Asian Americans have made to the United States, this volume presents biographical sketches of Asian Americans who can serve as role models for today's youth. The profiles in the series show the triumph of the human spirit. Volume…

  13. Regional Organizations and Opportunity in Nigeria

    DTIC Science & Technology

    2012-11-02

    tab_Bud_Planned&tabI D=tab_sct_Peace_Planned. 80 Faith Karimi and Katarina Hoije, “International Leaders Push for Military Intervention in Mali...of the AU: The Hurdles and the Triumphs." New African 519 (July 2012): 10-14. Accessed 15 September 2012. ProQuest. Karimi , Faith, and Katarina

  14. The Valley Forge Encampment: Epic on the Schuylkill.

    ERIC Educational Resources Information Center

    Trussell, John B. B., Jr.

    Valley Forge, outside Philadelphia (Pennsylvania), has long been recognized as the site of a great victory of the human spirit. Eleven thousand men including Blacks and Indians resided there during the winter of 1777-78 and triumphed over cold, starvation, nakedness, disease, and uncertainty. The encampment site was unprepared for the tattered,…

  15. The Conundrums of the University's Ideological Battlegrounds

    ERIC Educational Resources Information Center

    Nelson, Stephen J.

    2016-01-01

    The lively experiment that "is" the college and university in America is characterized by sustained struggles and tempered triumphs that have both undergirded and challenged the fundamental foundation of the academy. Large questions shape the framework of the academy in America. These include: ideological and political correctness, the…

  16. Academic Studies, Science, and Democracy: Conceptions of Subject Matter from Harris to Thorndike

    ERIC Educational Resources Information Center

    Watras, Joseph

    2009-01-01

    When Ellen Condliffe Lagemann described what she called the troubling history of education research, she claimed that, in the early years of the twentieth century, Edward Lee Thorndike's narrow model of science replaced John Dewey's more open ideas. According to Lagemann, sexism was an important reason for Thorndike's triumph. In describing the…

  17. What’s Wrong with the Wound Ballistics Literature, and Why

    DTIC Science & Technology

    1987-07-01

    ballistics shifted from sound scientific method to spectacular cinematography --a triumph of highI technology over common sense. Unfortunately, a...817. 34. Gill W, Long WB III: Shock Trauma Manual . Baltimore, Williams & Wilkins, 1978, p 35. 35. Rybeck B: Missile wounding and hemodynamic effects

  18. The Social-Ecological Ideal.

    ERIC Educational Resources Information Center

    Gaidamak, A.; Tiittanen, T.

    1992-01-01

    Argues that it is essential for preschool education to explore environmental and ecological values. Discusses cognitive development of socio-ecological knowledge at three age levels. Asserts that folk tales provide good examples of ecological values because beauty usually triumphs over ugliness and good over evil. (CFR)

  19. Real time, TV-based, point-image quantizer and sorter

    DOEpatents

    Case, Arthur L.; Davidson, Jackson B.

    1976-01-01

    A device is provided for improving the vertical resolution in a television-based, two-dimensional readout for radiation detection systems such as are used to determine the location of light or nuclear radiation impinging a target area viewed by a television camera, where it is desired to store the data indicative of the centroid location of such images. In the example embodiment, impinging nuclear radiation detected in the form of a scintillation occurring in a crystal is stored as a charge image on a television camera tube target. The target is scanned in a raster and the image position is stored according to a corresponding vertical scan number and horizontal position number along the scan. To determine the centroid location of an image that may overlap a number of horizontal scan lines along the vertical axis of the raster, digital logic circuits are provided with at least four series-connected shift registers, each having 512 bit positions according to a selected 512 horizontal increment of resolutions along a scan line. The registers are shifted by clock pulses at a rate of 512 pulses per scan line. When an image or portion thereof is detected along a scan, its horizontal center location is determined and the present front bit is set in the first shift register and shifted through the registers one at a time for each horizontal scan. Each register is compared bit-by-bit with the preceding register to detect coincident set bit positions until the last scan line detecting a portion of the image is determined. Depending on the number of shift registers through which the first detection of the image is shifted, circuitry is provided to store the vertical center position of the event according to the number of shift registers through which the first detection of the event is shifted. Interpolation circuitry is provided to determine if the event centroid is between adjacent scan lines and stored in a vertical address accordingly. The horizontal location of the event

  20. Teaching To Learn: Reflections on Risk-Taking. Bill Harp Professional Teachers Library.

    ERIC Educational Resources Information Center

    Cusack, Margaret S.

    This book is a discussion of teaching as learning--rooted in the author's personal history as a teacher and learner, and offered as one story among many to help other teachers ask questions about their own practice. The book is not intended to be a manual or a step-by-step guide for use in the classroom. Instead, it emphasizes the triumphs that…

  1. Linguistic analysis of verbal and non-verbal communication in the operating room.

    PubMed

    Moore, Alison; Butt, David; Ellis-Clarke, Jodie; Cartmill, John

    2010-12-01

    Surgery can be a triumph of co-operation, the procedure evolving as a result of joint action between multiple participants. The communication that mediates the joint action of surgery is conveyed by verbal but particularly by non-verbal signals. Competing priorities superimposed by surgical learning must also be negotiated within this context and this paper draws on techniques of systemic functional linguistics to observe and analyse the flow of information during such a phase of surgery.

  2. Development of a Metabolically Active, Non-Replicating Sporozoite Vaccine to Prevent Plasmodium falciparum Malaria

    DTIC Science & Technology

    2009-10-01

    induce greater than 90o/o protection. All available with different transmission intensities and seasonality will assess data indicate that greater...maturity (replication deficient at the liver stages), or mature liver National Institute of Allergy and Infectious Disease, Small Business stages that...Institute of Allergy and Infectious Diseases, National Institutes of Health 2002. 14. Barquet N, Domingo P. Smallpox: the triumph over the most

  3. Migrating to 9.1 -- Why Not...How Hard Could It Be?

    NASA Technical Reports Server (NTRS)

    Little, Keith; Miller, Carole; Schwindt, Paul; Zimmerman, Cheryl

    2011-01-01

    With 19+ Million documents in the 8.0 Vault. the decision was to migrate only selected top-level Documents, Drawings, Models and Assemblies to Kennedy Space Center's Brand-Spankin-New 9.1 Windchill system. Come with us as we detail our journey. We'll share our triumphs. tools, and approaches, as well as our challenges (and a surprise or two) discovered on the trip.

  4. Riffing on the universe

    NASA Astrophysics Data System (ADS)

    Cox, Trevor

    2016-05-01

    Music and physics might seem like polar opposites, one having great emotional potency and the other being a cerebral subject of equations, theories and deductions. Both, however, benefit from improvisers - people who stand on the shoulders of giants, taking earlier triumphs and building on them to create something new. For me, analogies like these, which draw parallels between physicists and jazz musicians, are the most fascinating revelations in Stephon Alexander's book The Jazz of Physics.

  5. What now, Asclepius? Lessons from Olympus.

    PubMed

    Moore, M R

    1996-10-01

    Asclepius, the Greek and Roman god of healing, is called before a council of gods on Mount Olympus to account for the shortcomings of his mortal descendants, the present day physicians. Accusations by the gods and Asclepius' defense and explanation bring the gods an understanding of human history and what physicians must become if humanity is to triumph over disease. Asclepius hopes the modern medical profession will understand also.

  6. The Civil War: Black American Contributions to Union Intelligence

    DTIC Science & Technology

    1999-01-01

    Arizona, on 30 June 1995. Tubman �s Triumphs Harriet Tubman , another black woman involved in intelligence col lection for the Union, is much more famous for...raiding party up the Harriet Tubman From Great Negroes Past and Present, Volume 1, by Russell L. Adams, African American Images, Chicago, Illinois...developed an interest in the Union flag-signal system, and he learned all he could about it. The intelligence Harriet Tubman and her spy organization

  7. The Chinese Communist Armed Forces.

    DTIC Science & Technology

    1974-01-01

    Kiangsu. Eastern Chekiang. Civil War, 1945-1949. (Translated by T. Osato and L. Gelas). p. 44. Hawainan (south of Hwai River ). Hwaipei (north of Hwai River ...of Taiwan swift-flowing rivers and streams . To get supplies in and Tibet and, also, how best to lend Ho Chi-minh by truck, the troops had to build...32 Evolution of Mao’s Military Doctrine .............................. 34V! V THE CIVIL WAR AND THE TRIUMPH OF MAO

  8. Cecilia Helena Payne-Gaposchkin

    NASA Astrophysics Data System (ADS)

    Braden, Antony; Contreras, Adelso

    2009-10-01

    This project will briefly tell the story of one of the 20^th century's most prominent astronomers, who through perseverance triumphed at the center of astrophysics. It also tells the story of the rough times in which Cecilia Helena Payne-Gaposchkin lived in as women then were held to much lower standards than they are today and endured unjust conditions. It also provides an analysis of the evolution of the astrophysics of stellar composition over a lengthy and prosperous career.

  9. Science and Technology in Development Environments - Industry and Department of Defense Case Studies

    DTIC Science & Technology

    2003-11-01

    invited by the U.S. Government to become a major player in nuclear power based on reputation and size. 9...organization’s triumphs and failures were openly shared, and GE’s top players were challenged and tested. The quarterly CEC meetings, the October/November...create a larger market for all players . 2 Ibid., pp. 17-B-9–17-B-10. The original Sun workstations

  10. U.S. Participation in Balkan Peacekeeping: The Rice Proposal

    DTIC Science & Technology

    2001-12-01

    European Community was not inclined to have the United States enter the conflict. Luxembourg foreign minister Jacques Poos, speaking as chairman of the...coupled 31 Jacques Poos on the ITN News, June 28, 1991, quoted in James Gow, Triumph of the Lack...Set For Ground War,” London Times, 11 October 2001. 249 Vernon Loeb and Thomas E. Ricks, “U.S. Sends Troops To Ex-Soviet Republics,” The

  11. Close Air Support versus Close Combat Attack

    DTIC Science & Technology

    2012-12-06

    Thomas Alexander. Over Lord: General Pete Quesada and the Triumph of Tactical Air Power in World War II. New York: Free Press, 1995. Hume , David B... David Tohn, On Point – The United States Army in Operation Iraqi Freedom, (Fort Leavenworth, KS; Center for Army Lessons Learned, 2004), 405. 55...Mar/Apr 1996). Davis, Richard G. The 31 Initiatives. Washington, DC: Office of Air Force History, 1987. Fontenot, Gregory , E.J. Degen, and David

  12. The Recourse to War: An Appraisal of the ’Weinberger Doctrine’

    DTIC Science & Technology

    1989-06-01

    colonial rule, the !ate Jomo Kenyatta was imprisoned after being found guilty of involvement with the Mau Mau terrorist organization. A decade later...following the triumph of the Black revolutionaries, Kenyatta was eiqcted President of an independent Kenya. He is remembered today as the "Wise Father’ of...children in the Palestinian village of Deir Yassin. Kenyatta and Begin Cbviously saw their support of, and involvement in, violence as fighting for freedom

  13. Safety and Mission Assurance: A NASA Perspective

    NASA Technical Reports Server (NTRS)

    Higginbotham, Scott A.

    2016-01-01

    Manned spaceflight is an incredibly complex and inherently risky human endeavor. As the result of the lessons learned through years of triumph and tragedy, the National Aeronautics and Space Administration (NASA) has embraced a comprehensive and integrated approach to the challenge of ensuring safety and mission success. This presentation will provide an overview of some of the techniques employed in this effort, with a focus on the processing operations performed at the Kennedy Space Center (KSC).

  14. Submarine Warfare in the 20th & 21st Centuries: A Bibliography

    DTIC Science & Technology

    2003-12-01

    Strategic and International Studies, 1998. (CSIS panel reports). 42 p. NPS/DKL Location: GENERAL VA50 .G68 1998 Harris , Brayton. The Navy times book...Minardi, Salvatore. Il disarmo navale italiano (1919-1936): un confronto politico- diplomatico per il potere marittimo. Roma: Ufficio storico della...NAVAL STRATEGY/WARFARE -- WWII – GENERAL Bath, Alan Harris . Tracking the axis enemy: the triumph of Anglo-American naval intelligence. Lawrence, KS

  15. From Seige to Surgical: The Evolution Of Urban Combat From World War II To The Present And Its Effect on Current Doctrine.

    DTIC Science & Technology

    1998-01-01

    up of thick stone structures with cellars. Throughout its history , space in Aachen was at a premium so buildings had been constructed with...Army in World War II, The War in the Pacific: Triumph in the Philippines (Washington, DC: Office of the Chief of Military History , Department of the...Campaign (Washington: Office of the Chief of Military History , Department of the Army, 1984), 307. 2 Ibid., 307. 3 Ibid., 29. 4 Charles Whiting

  16. Blood Far Forward: Time to Get Moving!

    DTIC Science & Technology

    2015-06-01

    beginning at the point of injury. LOOKING BEHIND TO FIND THE FUTURE In the late 1960s, whole blood was replaced with crys- talloids and colloids for...What was the evidence for switching to colloids and crystalloids and what is the evidence for returning to blood? Extensive expe- rience and knowledge... colloid solutions in trauma resuscitation represents the triumph of hope and wishful thinking over physiology and experience.19 Ironically, surgeons

  17. The Effect of a Soap Film on a Catenary: Measurement of Surface Tension from the Triangular Configuration

    ERIC Educational Resources Information Center

    Behroozi, F.; Behroozi, P. S.

    2011-01-01

    A chain assumes the well-known shape known as a catenary when it hangs loosely from two points in a gravitational field. The correct solution of the catenary was one of the early triumphs of the newly invented calculus of variations at the end of the 17th century. Here we revisit the catenary and show that, for a chain hanging from a horizontal…

  18. United States Air Force Academy: A Bibliography 2011-2015

    DTIC Science & Technology

    2016-11-23

    site=ehost-live>. 5 46. Dabrowski, Richard (Lt. Col.). "Editor’s Message: Birds of Different Feathers Collaborate in Language Education...239. "Falcon Triumph: Air Force Retains the Commander-in-Chief’s Trophy and Commander-in-Chief’s Trophy Call -Backs." Checkpoints 40.3 (December...Main ed.: A1, A4-A5. Print. 254. ---. "A Broken Code: AFA Superintendent Calls for Investigation of Athletic Transgressions." The Gazette 3

  19. 2015 CEC Annual Workshop on Electrochemistry

    DTIC Science & Technology

    2015-12-30

    for Diabetes Management. 11:30a-1:10p Lunch break. 1:10-2:00p Rebecca Lai, University of Nebraska-Lincoln Folding- and Dynamics-based...University of Texas at Austin “Glucose Monitoring for Diabetes Management” Adam Heller is Professor Emeritus in the McKetta Department of Chemical...Engineering at UT- Austin and consultant to Abbot Diabetes Care. Generally considered to represent the greatest triumph in the commercialization of

  20. Fast Tracks to Intelligence

    NASA Astrophysics Data System (ADS)

    Calvin, W. H.

    It is often assumed that the evolution of intelligence is inevitable, given the self-organizing seen in dissapative systems and the gradual shaping-up of Darwinism. While compound-interest reasoning suggests that small advantages will eventually triumph, eventually may be a very long time: there are few examples of rapid brain growth, suggesting that "smarter-is-better" is not a potent force for evolution.

  1. Reflections on Behavior Analysis and Evolutionary Biology: A Selective Review of Evolution Since Darwin—The First 150 Years. Edited by M. A. Bell, D. J. Futuyama, W. F. Eanes, & J. S. Levinton

    PubMed Central

    Donahoe, John W

    2012-01-01

    This review focuses on parallels between the selectionist sciences of evolutionary biology and behavior analysis. In selectionism, complex phenomena are interpreted as the cumulative products of relatively simple processes acting over time—natural selection in evolutionary biology and reinforcement in behavior analysis. Because evolutionary biology is the more mature science, an examination of the factors that led to the triumph of natural selection provides clues whereby reinforcement may achieve a similar fate in the science of behavior.

  2. Situational Ignorance; The UN and Security Sector Development in Timor-Leste

    DTIC Science & Technology

    2010-03-01

    regular and special forces using modern US weapons and aircraft.40 FALINTIL’s first commander, Nicolau Lobato ,41 Xanana Gusmão became the commander...line FRETILIN aligning with Minister of Interior Rogerio Lobato , while President Gusmão retained the allegiance of senior F-FDTL personnel. was...and recognized that 40 Ballard, Triumph of Self-Determination, 10. 41 Lobato is a Timorese folk hero. He was the elder brother of Rogerio Lobato

  3. Revival of Political Islam in the Aftermath of the Arab Uprisings: Implications for the Region and Beyond

    DTIC Science & Technology

    2014-07-01

    they need- 8 ed for landslide victories. The triumph of Islamists in elections can be attributed to two main factors. First, the popularity of these...resulted in dramatic losses of Muslim Brotherhood candidates in the 2010 11 parliamentary elections, and a landslide victory for the NDP. Meanwhile in...from carnegieendow- ment.org/files/PO22.hamzawy.FINAL.pdf. 11. Ashraf Swelam, “Egypt’s 2010 Parliamentary Elections: The Landslide ,” Egypt’s

  4. The Coast Artillery Journal. Volume 82, Number 1, January-February 1939

    DTIC Science & Technology

    1939-02-01

    YOll :t ::: order, you have but ONE letter to :t+ + ~ write . If a change of address becomes :t + ~~ necessary, ONE letter does the trick. t ::: ONE...mountaineer. MURAT 1 " You bave /10 aide of tbe rank of colo- nel," tbe Gascon pronounced, and slapped bis cbest IIntil ever)’tbing jangled. "[ will...borne. Thanks be to you , soldiers! Your victories presage more splendid triumphs still. But, soldiers, you have accomplished nothing, since so much

  5. JPRS Report, Soviet Union, World Economy & International Relations, No. 6, June 1988

    DTIC Science & Technology

    2007-11-02

    national income . The accumulation of capital was impeded increasingly by the growing spending of the "welfare state". From 1950 through 1976...tunity to have our due say in defense of peace and justice on Earth. The millennial anniversary of the baptism of Rus will, we hope, be a triumph...usually high even for the East (up to one - fourth of the gross agricultural product). As a result of the introduction by the British of new land-tax

  6. Do infants discriminate non-linguistic vocal expressions of positive emotions?

    PubMed

    Soderstrom, Melanie; Reimchen, Melissa; Sauter, Disa; Morgan, James L

    2017-02-01

    Adults are highly proficient in understanding emotional signals from both facial and vocal cues, including when communicating across cultural boundaries. However, the developmental origin of this ability is poorly understood, and in particular, little is known about the ontogeny of differentiation of signals with the same valence. The studies reported here employed a habituation paradigm to test whether preverbal infants discriminate between non-linguistic vocal expressions of relief and triumph. Infants as young as 6 months who had habituated to relief or triumph showed significant discrimination of relief and triumph tokens at test (i.e. greater recovery to the unhabituated stimulus type), when exposed to tokens from a single individual (Study 1). Infants habituated to expressions from multiple individuals showed less consistent discrimination in that consistent discrimination was only found when infants were habituated to relief tokens (Study 2). Further, infants tested with tokens from individuals from different cultures showed dishabituation only when habituated to relief tokens and only at 10-12 months (Study 3). These findings suggest that discrimination between positive emotional expressions develops early and is modulated by learning. Further, infants' categorical representations of emotional expressions, like those of speech sounds, are influenced by speaker-specific information.

  7. Blood Doping: Results and Consequences From the Laboratory and the Field.

    PubMed

    Eichner, E R

    1987-01-01

    In brief: Just as Roman gladiators drank the blood of foes to gain strength, modern Olympians have infused the blood of friends as well as their own to gain endurance. Blood doping, which tainted the triumphs of the 1984 US Olympic cyclists, has at last been banned. This literature review defines blood doping, discusses its use and rationale, and presents some of the research findings. The conclusion is that blood doping, properly performed, works in the laboratory, but there is insufficient evidence to show conclusively that it works in the field.

  8. Environmental hazards and public health: lessons for the practice of medicine and for public policy

    SciTech Connect

    Wedeen, R.P.; Sheehan, H.E. )

    1992-01-01

    The separation of occupational and environmental disease from the mainstream of medical practice has deep roots in the culture of the profession. Medical practice centered on individual patient care as nineteenth-century science yielded the therapeutic triumphs of the twentieth century. Social issues seemed remote to medical practitioners as the rewards of scientifically based therapies upstaged the unglamorous aspects of preventive medicine. Public health was left to politicians and bureaucrats. Victorian ambivalence toward the less successful members of society reinforced the isolation of medicine from public policy. As a consequence, physicians are largely ignored in contemporary debates about environmental hazards, to the detriment of both society and the profession.

  9. Outing the costs of civil deference to the military.

    PubMed

    Hillman, Elizabeth L

    2013-01-01

    Placing the costs and process of repeal into the framework of U.S. civil governance and military power reveals the faltering state of civilian control over, and understanding of, contemporary military institutions. The excessive delays, repetitive studies, and lack of judicial oversight that characterized the process of repeal expose a military unmoored from the constitutional and democratic constraints of civilian control. The end of Don't Ask, Don't Tell is more than a civil rights triumph. It is also a lesson in the steep costs and troubling consequences of excessive civilian deference to the armed forces.

  10. Further thoughts on agrarian capitalism: a reply to Albritton.

    PubMed

    Zmolek, M

    2001-01-01

    In response to Albritton [2000], who asserts that the central dynamic of capitalism's genesis was putting-out manufacturing, I provide a sketch of the processes of agrarian capitalism. The elaboration of the common law in the Middle Ages enabled widespread conversion to leaseholds after the plague. An increasingly privatized system of land ownership resulted from the enclosure movement in the fifteenth and sixteenth centuries, and the upheavals of the seventeenth century represented the triumph of the enclosers. The rise of cottage industry in the eighteenth century was supported by a systematic effort at improving agricultural productivity. By the Industrial Revolution, the principle of individual control over production had long been established.

  11. Experimental Semiconductor Physics: The Will to Contribute to the Country’s Economic Development

    NASA Astrophysics Data System (ADS)

    Vigil Santos, Elena

    During the second half of the 1960s the Physics School staff increased sharply. Before this, it had experienced near depletion due to the emigration of many of its members shortly after the triumph of the Revolution. This renaissance took place thanks to the incorporation of the first physicists to graduate from the Physics School itself, and to the return of those who had graduated abroad, mainly from the former Soviet Union. This group of young physicists—with a heavy schedule of teaching duties in spite of their lack of experience—gave strong support to the development of physics in Cuba.

  12. ORAL ISSUE OF THE JOURNAL "USPEKHI FIZICHESKIKH NAUK": Sixty years of broken symmetries in quantum physics (from the Bogoliubov theory of superfluidity to the Standard Model)

    NASA Astrophysics Data System (ADS)

    Shirkov, Dmitrii V.

    2009-06-01

    This is a retrospective historical review of the ideas that led to the concept of the spontaneous symmetry breaking (SSB), the issue that has been implemented in quantum field theory in the form of the Higgs mechanism. The key stages covered include: the Bogoliubov microscopic theory of superfluidity (1946); the Bardeen-Cooper-Schrieffer-Bogoliubov microscopic theory of superconductivity (1957); superconductivity as superfluidity of Cooper pairs (Bogoliubov, 1958); the extension of the SSB concept to simple quantum field models (early 1960s); triumph of the Higgs model in electroweak theory (early 1980s). The role and status of the Higgs mechanism in the current Standard Model are discussed.

  13. Harbin consensus conference and quality of infertility trials: reflections of a scientist on the Italian experience

    PubMed Central

    2013-01-01

    During the days August 22–24, 2013 has been held in Harbin (China) an International Consensus Conference aimed to improve the quality and the reporting of the randomized controlled trials (RCTs) in infertility and subfertility field. I, as Italian scientist with experience in clinical infertility trials, was invited to have a speech on the Italian experience in RCTs, with particular regard for the surgical trials. Considerations on this subject were particularly interesting to highlight pitfalls and triumphs of research in Italy. PMID:24257071

  14. Hubble Space Telescope - Scientific, Technological and Social Contributions to the Public Discourse on Science

    NASA Technical Reports Server (NTRS)

    Wiseman, Jennifer

    2012-01-01

    The Hubble Space Telescope has unified the world with a sense of awe and wonder for 2 I years and is currently more scientifically powerful than ever. I will present highlights of discoveries made with the Hubble Space Telescope, including details of planetary weather, star formation, extra-solar planets, colliding galaxies, and a universe expanding with the acceleration of dark energy. I will also present the unique technical challenges and triumphs of this phenomenal observatory, and discuss how our discoveries in the cosmos affect our sense of human unity, significance, and wonder.

  15. [Hatred and change of love into hatred from the psychiatric nosological aspect (author's transl)].

    PubMed

    Dietrich, H

    1976-09-10

    Pathological hatred affects belong to the paranoic reactions, paranoic developments and paranoid psychoses. The normal hatred affect helps as a means to the end of removing the object of hatred. The passion of hatred is an affect swinging between a feeling of triumph and a feeling of impotence and the cardinal symptom of a paranoic neurotic development. Hatred becomes monomania when the affect degenerates maniacally (e. g. queruousness) or perversely (e. g. misogyny). In catathymic mania, hatred is projected on to the "pursuer". The metamorphosis of love into hatred is historically and dynamically behind all normal and pathological manifestations of hatred.

  16. Mathematical universality and direct applicability of evolutionary games. Comment on "Universal scaling for the dilemma strength in evolutionary games", by Z. Wang et al.

    NASA Astrophysics Data System (ADS)

    Arranz, Jordi; Traulsen, Arne

    2015-09-01

    The application of classical game theory to biological sciences allowed researchers to successfully approach problems in theoretical and evolutionary biology in a novel manner [1]. Among those, the evolution of cooperation is the most popular application of evolutionary game theory. The evolution of cooperation is traditionally modeled through games, in particular social dilemmas. These depict situations, in which the interest of an individual is in conflict with the interest of the group, thus games offer an ideal ground to study how cooperation can emerge in the face of natural selection, where individual advantage triumphs over group benefits.

  17. The second Jurassic dinosaur rush and the dawn of dinomania.

    PubMed

    Brinkman, Paul D

    2010-09-01

    During the second Jurassic dinosaur rush museum paleontologists raced to display the world's first mounted sauropod dinosaur. The American Museum of Natural History triumphed in 1905 when its Brontosaurus debuted before an admiring crowd of wealthy New Yorkers. The Carnegie Museum of Natural History in Pittsburgh, the Field Columbian Museum in Chicago and other institutions were quick to follow with their own sauropod displays. Thereafter, dinomania spread far and wide, and big, showpiece dinosaurs became a museum staple. This brief but intensely competitive period of acquisitiveness fostered important Jurassic dinosaur revisions and crucial innovations in paleontological field and lab techniques.

  18. Supply of medicines: paternalism, autonomy and reality.

    PubMed Central

    Prayle, D; Brazier, M

    1998-01-01

    Radical changes are taking place in the United Kingdom in relation to the classification of, and access to, medicines. More and more medicines are being made available over the counter both in local pharmacies and in supermarkets. The provision of more open access to medicines may be hailed as a triumph for patient autonomy. This paper examines whether such a claim is real or illusory. It explores the ethical and legal implications of deregulating medicines. Do patients benefit? What is the impact on pharmacists? Are the true beneficiaries of change largely the pharmaceutical industries? PMID:9602995

  19. Community College's CAN do Research A Decade of Eclipse Expeditions

    NASA Astrophysics Data System (ADS)

    Saken, Jon M.

    2006-12-01

    Gale force winds, ravenous Tsetse flies and duct-tape equipment repairs. Now that's science! This talk will describe the triumphs and disasters over almost a decade of world-wide astronomical expeditions involving community college students, faculty and K-12 teachers chasing one of nature's most spectacular shows a total solar eclipse. The impact of this kind of field science on the participants and the wider community, along with other lessons learned along the way, will also be discussed, as we present ideas to encourage others to join in the fun.

  20. Forensic psychiatry and the birth of the criminal insane asylum in modern Italy.

    PubMed

    Gibson, Mary

    2014-01-01

    This paper focuses on the creation of the criminal insane asylum in Italy between unification in 1861 and World War I. The establishment of criminal insane asylums was a triumph of the positivist criminology of Cesare Lombroso, who advocated for an institution to intern insane criminals in his classic work, Criminal Man (1876). As a context for the analysis of the birth of the criminal insane asylum in Italy, this essay also outlines the history of the insanity plea in Italian criminal law and the young discipline of psychiatry during the fifty years after Italian unification.

  1. How sex became gender.

    PubMed

    Nye, Robert A

    2010-01-01

    This article argues that "sex" which had been commonly assumed in the West to refer to a permanent set of biological and behavioural traits particular to men and women, is gradually being replaced in general usage by "gender." Though feminist theorists attempted to attach a constructivist meaning to gender, a generation of developmental theorists, clinicians and analysts has imbued the term with the determinism and biological qualities formerly ascribed to "sex." The triumph of this materialist conception of gender is not assured, but it threatens our ability to think about gender identity as a historically-constructed category.

  2. Nobel Prize in Chemistry. Development of the Olefin Metathesis Method in Organic Synthesis

    NASA Astrophysics Data System (ADS)

    Casey, Charles P.

    2006-02-01

    The 2005 Nobel Prize in Chemistry was awarded to Yves Chauvin of the Institut Français du Pétrole, Robert H. Grubbs of CalTech, and Richard R. Schrock of MIT "for development of the metathesis method in organic synthesis". The discoveries of the laureates provided a chemical reaction now used daily in the chemical industry for the efficient and more environmentally friendly production of important pharmaceuticals, fuels, synthetic fibers, and many other products. This article tells the story of how olefin metathesis became a truly useful synthetic transformation and a triumph for mechanistic chemistry, and illustrates the importance of fundamental research. See JCE Featured Molecules .

  3. Megatrends for the information age.

    PubMed Central

    Aburdene, P

    1994-01-01

    The 1990s are a decade characterized by change. Technological advances and health care reform are changing the demand for and provision of biomedical information, while political, economic, and social change are transforming the larger environment. There are four important megatrends shaping the global future: the new world order, the renaissance of the arts, the triumph of the individual, and the decade of women in leadership. Preparing to take advantage of the opportunities created by these changes is essential for organizations to survive and for individuals to become leaders. PMID:8136755

  4. Fractals and the birth of Gothic: reflections on the biologic basis of creativity.

    PubMed

    Goldberger, A L

    1996-05-01

    The birth of Gothic, one of the great triumphs of human spiritual and artistic expression, would appear to be a topic remote from the enterprise of contemporary neurobiology. The intent of this brief essay is to explore the possibility that this singular architectural movement may have important implications for understanding the nonlinear dynamics of the brain. We explore the hypothesis that the Gothic cathedral, with its porous, scale-free structures, may represent an externalization of the fractal properties of our physiology in general, and of our neural architectures and neuro-dynamics, in particular.

  5. Ground deformation cycles participating with sub-Plinian, Vulcanian eruptions, and a magma effusive stage at Kirishima volcanoes

    NASA Astrophysics Data System (ADS)

    Takeo, M.; Maehara, Y.; Ohminato, T.; Ichihara, M.; Oikawa, J.

    2012-12-01

    /or deflation steps associated with a volcanic glow or a phreatomagmatic eruption which occurred before the Vulcanian eruption. The time sequences of preceding inflations were progressively complicated through the frequent Vulcanian eruptions, and finally, deflation steps participating with a volcanic glow and a phreatomagmatic eruption were appeared during the preceding inflation periods of two Vulcanian eruptions on 7 February 2011. The progressive change of time sequences suggests that strength heterogeneity of filled magma had been gotten larger bit by bit through the repeating Vulcanian eruptions. In spite of the complicated time sequences of preceding inflations, we reveal the clear linearity with the constant gradient of 0.45 between the logarithm of preceding durations versus the elapsed time counting on the date time scale form the reference date of each sub-stage. These observations are consistently interpreted based on the concepts that a Vulcanian eruption is induced by a sudden fracturing of strongest magma frame due to overpressure caused by magma degassing, and amount of degassing from magma decline exponentially with progress of time.

  6. Importance of Technical Writing in Engineering Education

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2010-12-01

    ., Grasha, A., & Richlin, L. (1997, March). Town meeting. Between teaching model and learning model: Adapting and adopting bit by bit. Paper presented at the ninth annual Lilly Conference on College and University Teaching - West, Lake Arrowhead, CA. Narayanan, Mysore (2009). Assessment Based on the principles of Theodore Marchese. ASEE 116th Annual Conference and Exposition, Austin, TX. June 14-17, 2009. Paper # AC 2009-1532. Saxe, S. (1990, June). Peer influence and learning. Training and Development Journal, 42 (6), 50-53. Senge, P. M. (1990). The fifth discipline: The art and practice of the learning organization. New York: Currency Doubleday. Sims, R. R. (1992, Fall). Developing the learning climate in public sector training programs. Public Personnel Management, 21 (3), 335-346. Kosakowski, John, (1998). The Benefits of Information Technology. ERIC Digests; Technology Integration; Technology Role, ED0-IR-98-04 Chaika, Gloria (2000), Encourage Student Writing: Published on the Web, Education World http://www.education-world.com/a_tech/tech042.shtml

  7. Radiation from an accelerating neutral body: The case of rotation

    NASA Astrophysics Data System (ADS)

    Yarman, Tolga; Arik, Metin; Kholmetskii, Alexander L.

    2013-11-01

    When an object is bound at rest to an attractional field, its rest mass (owing to the law of energy conservation, including the mass and energy equivalence of the Special Theory of Relativity) must decrease. The mass deficiency coming into play indicates a corresponding rest energy discharge. Thus, bringing an object to a rotational motion means that the energy transferred for this purpose serves to extract just as much rest mass (or similarly "rest energy", were the speed of light in empty space taken to be unity) out of it. Here, it is shown that during angular acceleration, photons of fundamental energy are emitted, while the object is kept on being delivered to a more and more intense rotational accelerational field, being the instantaneous angular velocity of the rotating object. This fundamental energy, as seen, does not depend on anything else (such as the mass or charge of the object), and it is in harmony with Bohr's Principle of Correspondence. This means at the same time, that emission will be achieved, as long as the angular velocity keeps on increasing, and will cease right after the object reaches a stationary rotational motion (a constant centrifugal acceleration), but if the object were brought to rotation in vacuum with no friction. By the same token, one can affirm that even the rotation at a macroscopic level is quantized, and can only take on "given angular velocities" (which can only be increased, bit by bit). The rate of emission of photons of concern is, on the other hand, proportional to the angular acceleration of the object, similarly to the derivative of the tangential acceleration with respect to time. It is thus constant for a "constant angular acceleration", although the energy of the emitted photons will increase with increasing , until the rotation reaches a stationary level, after which we expect no emission --let us stress-- if the object is in rotation in vacuum, along with no whatsoever friction (such as the case of a rotating

  8. Writers, Athletes and Engineers Learn by Doing

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2009-12-01

    provided evidence-based reasoning and critical thinking. 6. He/She has suggested a time-line for completing the assignment. 7. The person has completed the required process in the alloted time-line. In this presentation the author stresses the importance of writing assignments in engineering disciplines. References: Barr, R. B., & Tagg, J. (1995, November/December). From teaching to learning: A new paradigm for undergraduate education. Change: The Magazine of Higher Education, 13-24. Cox, M. D., Grasha, A., & Richlin, L. (1997, March). Town meeting. Between teaching model and learning model: Adapting and adopting bit by bit. Paper presented at the ninth annual Lilly Conference on College and University Teaching - West, Lake Arrowhead, CA. Narayanan, Mysore (2009). Assessment Based on the principles of Theodore Marchese. ASEE 116th Annual Conference and Exposition, Austin, TX. June 14-17, 2009. Paper # AC 2009-1532. Saxe, S. (1990, June). Peer influence and learning. Training and Development Journal, 42 (6), 50-53. Senge, P. M. (1990). The fifth discipline: The art and practice of the learning organization. New York: Currency Doubleday.

  9. The role of the Faculty of Public Health (Medicine) in developing a multidisciplinary public health profession in the UK.

    PubMed

    Griffiths, Sian; Crown, June; McEwen, Jim

    2007-06-01

    The Faculty of Public Health (FPH) started out its life as the Faculty of Community Medicine. Its initial membership was drawn from the ranks of Medical Officers of Health (MOsH), medical administrators and consultants working in communicable disease. Born under the aegis of the three Royal Colleges of Physicians, it was de facto for members of the medical profession. This was despite the intention of some of the prime movers in its creation that its membership should reflect the multidisciplinary nature of specialist public health. As such, whilst the Faculty's establishment was indeed a triumph, the triumph was only partial, since many senior public health professionals were precluded from full membership. Over the years this situation has changed, but the road to the Faculty's current open policy, based on achieving public health excellence rather than holding a professional badge, has not been a smooth one. The fears of many medical members that the specialty would be down graded through opening up its membership posed successive presidents with many, often justifiable, challenges. In this article we, former presidents, reflect on the key events during our successive tenures.

  10. Historical aspects of the early Soviet/Russian manned space program.

    PubMed

    West, J B

    2001-10-01

    Human spaceflight was one of the great physiological and engineering triumphs of the 20th century. Although the history of the United States manned space program is well known, the Soviet program was shrouded in secrecy until recently. Konstantin Edvardovich Tsiolkovsky (1857-1935) was an extraordinary Russian visionary who made remarkable predictions about space travel in the late 19th century. Sergei Pavlovich Korolev (1907-1966) was the brilliant "Chief Designer" who was responsible for many of the Soviet firsts, including the first artificial satellite and the first human being in space. The dramatic flight of Sputnik 1 was followed within a month by the launch of the dog Laika, the first living creature in space. Remarkably, the engineering work for this payload was all done in less than 4 wk. Korolev's greatest triumph was the flight of Yuri Alekseyevich Gagarin (1934-1968) on April 12, 1961. Another extraordinary feat was the first extravehicular activity by Aleksei Arkhipovich Leonov (1934-) using a flexible airlock that emphasized the entrepreneurial attitude of the Soviet engineers. By the mid-1960s, the Soviet program was overtaken by the United States program and attempts to launch a manned mission to the Moon failed. However, the early Soviet manned space program has a preeminent place in the history of space physiology.

  11. Gamma irradiation as a phytosanitary treatment for fresh pome fruits produced in Patagonia

    NASA Astrophysics Data System (ADS)

    Pérez, J.; Lires, C.; Horak, C.; Pawlak, E.; Docters, A.; Kairiyama, E.

    2009-07-01

    Argentina produces 1.8 million tons/year of apples ( Malus domestica L.) and pears ( Pyrus communis L.) in the Patagonia region. Cydia pomonella, codling moth, and Grapholita molesta, Oriental fruit moth, ( Lepidoptera: Tortricidae) are quarantine pests in pome fruits. Irradiation is a promising phytosanitary treatment because a dose of 200 Gy completely prevents pest adult emergence. A pilot irradiation process of commercially packaged 'Red Delicious' apples and 'Packham's Triumph' pears was performed in an irradiation facility with a Cobalt 60 source. Quality analyses were carried out at 0, 2, 4, 6 and 8 months of storage (1 °C, RH 99%) to evaluate fruit tolerance at 200, 400 and 800 Gy. Irradiation at 200 and 400 Gy had no undesirable effects on fruit quality (pulp firmness, external colour, soluble solids content (SSC), titratable acidity (TA) and sensory evaluations). Irradiation of 'Red Delicious' apples and 'Packham's Triumph' pears can be applied as a commercial quarantine treatment with a minimum absorbed dose of 200 Gy (to control codling moth and Oriental fruit moth) and <800 Gy (according to quality results).

  12. Breast size, bra fit and thoracic pain in young women: a correlational study

    PubMed Central

    Wood, Katherine; Cameron, Melainie; Fitzgerald, Kylie

    2008-01-01

    Introduction A single sample study was undertaken to determine the strength and direction of correlations between: a) breast size and thoracic spine or posterior chest wall pain; b) bra fit and thoracic spine or posterior chest wall pain and; c) breast size and bra fit, in thirty nulliparous women (18–26 years), with thoracic spine or posterior chest wall pain, who wore bras during daytime. Measures Pain (Short Form McGill Pain Questionnaire), bra size (Triumph International), bra fit (Triumph International). Results Most (80%) women wore incorrectly sized bras: 70% wore bras that were too small, 10% wore bras that were too large. Breast size was negatively correlated with both bra size (r = -0.78) and bra fit (r = -0.50). These results together indicate that large breasted women were particularly likely to be wearing incorrectly sized and fitted bras. Negligible relationships were found between pain and bra fit, and breast size and pain. Menstrual cycle stage was moderately positively correlated with bra fit (r = 0.32). Conclusion In young, nulliparous women, thoracic pain appears unrelated to breast size. Bra fit is moderately related to stage of menstrual cycle suggesting that this research may be somewhat confounded by hormonal changes or reproductive stage. Further research is needed to clarify whether there is a relationship between breast size or bra fit and thoracic pain in women during times of hormonal change. PMID:18339205

  13. There is grandeur in this view of Newton: Charles Darwin, Isaac Newton and Victorian conceptions of scientific virtue.

    PubMed

    Bellon, Richard

    2014-01-01

    For Victorian men of science, the scientific revolution of the seventeenth century represented a moral awakening. Great theoretical triumphs of inductive science flowed directly from a philosophical spirit that embraced the virtues of self-discipline, courage, patience and humility. Isaac Newton exemplified this union of moral and intellectual excellence. This, at least, was the story crafted by scientific leaders like David Brewster, Thomas Chalmers, John Herschel, Adam Sedgwick and William Whewell. Not everyone accepted this reading of history. Evangelicals who decried the 'materialism' of mainstream science assigned a different meaning to Newton's legacy on behalf of their 'scriptural' alternative. High-church critics of science like John Henry Newman, on the other hand, denied that Newton's secular achievements carried any moral significance at all. These debates over Newtonian standards of philosophical behavior had a decisive influence on Charles Darwin as he developed his theory of evolution by natural selection.

  14. The Continuous Confrontation of Caregiving as Described in Real-Time Online Group Chat.

    PubMed

    Male, Dana A; Fergus, Karen D; Stephen, Joanne E

    2015-01-01

    To date, our understanding of the caregiver experience has been informed primarily by guided inquiry in the form of interviews and surveys, yielding information that is limited by the scope of researchers questions. The intent of this study was to explore the experience of caring for a loved one with advanced-stage cancer by means of participant-determined communication, using interactive, text-based transcripts from synchronous online support groups. Grounded theory analysis of the group transcripts yielded the core category continuous confrontation, characterized by major challenges (unrelenting assault, a new us, and the costs of caregiving) and minor triumphs (refuelling and living more intentionally). This unique method of data collection allowed for an especially candid, intersubjective group account of what it is to be a caregiver for an ill loved one without compromising the details that caregivers themselves consider important.

  15. Dark matter superfluidity and galactic dynamics

    NASA Astrophysics Data System (ADS)

    Berezhiani, Lasha; Khoury, Justin

    2016-02-01

    We propose a unified framework that reconciles the stunning success of MOND on galactic scales with the triumph of the ΛCDM model on cosmological scales. This is achieved through the physics of superfluidity. Dark matter consists of self-interacting axion-like particles that thermalize and condense to form a superfluid in galaxies, with ∼mK critical temperature. The superfluid phonons mediate a MOND acceleration on baryonic matter. Our framework naturally distinguishes between galaxies (where MOND is successful) and galaxy clusters (where MOND is not): dark matter has a higher temperature in clusters, and hence is in a mixture of superfluid and normal phase. The rich and well-studied physics of superfluidity leads to a number of striking observational signatures.

  16. Filling-enforced quantum band insulators in spin-orbit coupled crystals

    PubMed Central

    Po, Hoi Chun; Watanabe, Haruki; Zaletel, Michael P.; Vishwanath, Ashvin

    2016-01-01

    An early triumph of quantum mechanics was the explanation of metallic and insulating behavior based on the filling of electronic bands. A complementary, classical picture of insulators depicts electrons as occupying localized and symmetric Wannier orbitals that resemble atomic orbitals. We report the theoretical discovery of band insulators for which electron filling forbids such an atomic description. We refer to them as filling-enforced quantum band insulators (feQBIs) because their wave functions are associated with an essential degree of quantum entanglement. Like topological insulators, which also do not admit an atomic description, feQBIs need spin-orbit coupling for their realization. However, they do not necessarily support gapless surface states. Instead, the band topology is reflected in the insulating behavior at an unconventional filling. We present tight binding models of feQBIs and show that they only occur in certain nonsymmorphic, body-centered cubic crystals. PMID:27152352

  17. Julius Wagner-Jauregg and the Legacy of Malarial Therapy for the Treatment of General Paresis of the Insane

    PubMed Central

    Tsay, Cynthia J.

    2013-01-01

    Julius Wagner-Jauregg, a preeminent Austrian psychiatrist was awarded the Nobel Prize in Medicine in 1927 for the development of malaria therapy for the treatment of neurosyphilis, or general paresis of the insane. Despite being only one of three psychiatrists to win a Nobel Prize, he has faded from public consciousness and his name recognition pales in comparison to his contemporary and fellow Austrian, Sigmund Freud. This paper explores his contributions to the field of biological psychiatry and also touches upon reasons, such as the growing bioethics movement, his controversial affiliation with the Nazi Party, and the evolution of neurosyphilis, that explain why Wagner-Jauregg is not more widely celebrated for his contributions to the field of psychiatry, even though his malarial treatment could be considered the earliest triumph of biological psychiatry over psychoanalysis. PMID:23766744

  18. Ships at a distance: Energy choice and economic challenge

    SciTech Connect

    Bradford, P.A.

    1997-12-31

    Several restructurings of Vermont`s electric utilities were attempted earlier. At best, the successes were compromises, whose benefits were a fraction of what might have been achieved. At worst, monopoly power triumphed outright, leaving Vermonters and Vermont economy in thrall to distant energy and financial forces. To understand the interplay between today`s restructuring and the Vermont economy, the author examines those earlier restructuring. They establish that electricity really is different from other industries, not just because it cannot be stored or because the strandable investment is so much larger or the monopoly linkages are so much more extensive. More important is the extent of the electric industry`s place in the national political consciousness and its environmental impact.

  19. Universal Principles of Depicting Oneself across the Centuries: From Renaissance Self-Portraits to Selfie-Photographs.

    PubMed

    Carbon, Claus-Christian

    2017-01-01

    Selfie-photography is generally thought of as a cultural mass phenomenon of the early 21st century, inseparably related to the development and triumph of the smartphone with integrated camera. Western culture, however, has been highly familiar with self-depictions since the Renaissance days. Putting the contemporary selfie into this historic context covering more than five centuries of cultural development from Dürer's (1500) famous "Self-Portrait at 28" (also known as "Selbstbildnis im Pelzrock") to today's Instagram galleries allows for identifying central parallels concerning the technical and social antecedents as well as common underlying psychological factors and shared properties of different kinds of self-depiction. The article provides an overview of the types of contemporary photographic selfies and compares them with painted self-portraits. Finally, this historic perspective leads us to the insight that self-portraits as well as selfies are both referring to nothing less than the "conditio humana."

  20. Ross E. Baker, DC: A Canadian chiropractic survivor

    PubMed Central

    Brown, Douglas M.

    2014-01-01

    This paper is an historical biography of a fortunate man. It begins with a glimpse of Ross E. Baker’s origins in south-western Ontario, watches him going to school and working in Hamilton before joining the Canadian Army and shipping off to Europe to fight in the Second World War. At War’s end, the article picks up Dr. Baker as he comes home, starts a family, becomes a chiropractor and sustains a viable practice. Now in the twilight of life, the good doctor is last seen content with his retirement, spending days at his cottage property, reviewing his memoirs and reflecting on the tumult, terror and eventual triumph of the D-Day landing at Normandy. PMID:24587499

  1. Arctic and Antarctic exploration including the contributions of physicians and effects of disease in the polar regions.

    PubMed

    Fodstad, H; Kondziolka, D; Brophy, B P; Roberts, D W; Girvin, J P

    1999-05-01

    A history of Arctic and Antarctic exploration, whether to find a Northwest Passage, North Pole, or South Pole, is a story of triumph and tribulation. The hardship experienced by polar explorers in the last 1000 years permeates the tales of achievement. Physicians and surgeons have played prominent roles in all major polar explorations. No significant Arctic voyage, particularly in the last 300 years, was made without a member of the party trained in the management of medical emergencies and in basic surgery. During times of health, surgeons functioned as the voyage naturalists with expertise in biology, botany, zoology, and the writing of scientific catalogs. Spurred by our interest and fascination with the history of polar exploration, we reviewed the roles of physicians and natural scientists in Arctic and Antarctic adventures.

  2. "The foolmaster who fooled them".

    PubMed Central

    Young, J. H.

    1980-01-01

    Throughout the nineteenth century, physicians assumed the major task of analyzing and warning against quackery and unorthodoxy. The nature of this criticism is described, with key reliance on Worthington Hooker's Lessons from the History of Medical Delusions (1850). Most physicians viewed prospects for suppressing quackery more hopefully than Hooker did. Even he, however, would be shocked that delusion could persist so stubbornly despite advancing medical science, expanding education, and increasing regulation. Many factors help explain today's continuing-even burgeoning-quackery. These include a less cheerful view of both human nature and of the future, widespread skepticism about the fruits for science, impatience with governmental regulation, the vogue for self-help in health, increasing promotional sophistication on the part of unorthodox health vendors, and cooperation among various wings of unorthodoxy to maximize political pressure. Examples are given. Champions of alternative therapies predict their triumph over orthodox medical science in the contest being waged for the allegiance of the public. PMID:7018095

  3. The natural theology of Victorian industry.

    PubMed

    Fisher, Nick

    2015-03-01

    As clergymen in Britain celebrated the Great Exhibition in the summer of 1851 and drew appropriate moral lessons, there was widespread agreement that the triumphs of industry on display represented the fulfilment of God's will. The basic assumption was that overcoming God's curse on Adam had been possible only through sustained hard work - industry in the early Victorian sense - and that this imperative work ethic had always been God's intention for mankind. In elaborating the details, preachers combined the British tradition of natural theology with the Scottish Enlightenment's progressive science of man to paint a picture of the slow recovery of man from the Fall through his own industry. This was the very story of civilization itself, with God the driving force. The celebrants were quite clear that it was divine providence that had ordained the greatness of Great Britain.

  4. Richard Feynman and the History of Superconductivity

    NASA Astrophysics Data System (ADS)

    Goodstein, David; Goodstein, Judith

    This paper deals with two topics. One is the history of superconductivity, and the other is what Richard Feynman had to do with it. The history of superconductivity can be traced back to Michael Faraday and the first liquefaction of a gas in 1823. It is a heroic tale of triumph over cold and resistance, and once the phenomenon was actually discovered in 1911, it would take almost 50 years more before a satisfactory explanation emerged. Although Richard Feynman only authored one published paper on the subject, he worked prodigiously on the problem through much of the 1950s, and his competitors, particularly Bardeen, Cooper, and Schrieffer, fully expected that he would be the one to crack the problem. It did not work out that way.

  5. Progress in reforming chemical engineering education.

    PubMed

    Wankat, Phillip C

    2013-01-01

    Three successful historical reforms of chemical engineering education were the triumph of chemical engineering over industrial chemistry, the engineering science revolution, and Engineering Criteria 2000. Current attempts to change teaching methods have relied heavily on dissemination of the results of engineering-education research that show superior student learning with active learning methods. Although slow dissemination of education research results is probably a contributing cause to the slowness of reform, two other causes are likely much more significant. First, teaching is the primary interest of only approximately one-half of engineering faculty. Second, the vast majority of engineering faculty have no training in teaching, but trained professors are on average better teachers. Significant progress in reform will occur if organizations with leverage-National Science Foundation, through CAREER grants, and the Engineering Accreditation Commission of ABET-use that leverage to require faculty to be trained in pedagogy.

  6. Targeting CD8+ T-cell tolerance for cancer immunotherapy

    PubMed Central

    Jackson, Stephanie R; Yuan, Jinyun; Teague, Ryan M

    2014-01-01

    In the final issue of Science in 2013, the American Association of Science recognized progress in the field of cancer immunotherapy as the ‘Breakthrough of the Year.’ The achievements were actually twofold, owing to the early success of genetically engineered chimeric antigen receptors (CAR) and to the mounting clinical triumphs achieved with checkpoint blockade antibodies. While fundamentally very different, the common thread of these independent strategies is the ability to prevent or overcome mechanisms of CD8+ T-cell tolerance for improved tumor immunity. Here we discuss how circumventing T-cell tolerance has provided experimental insights that have guided the field of clinical cancer immunotherapy to a place where real breakthroughs can finally be claimed. PMID:25290416

  7. Are ``edge transport barriers'' a reality or a fantasy of TTF

    NASA Astrophysics Data System (ADS)

    Zakharov, Leonid

    2013-10-01

    For more than 3 decades, sharp electron temperature jumps (pedestals) at the plasma edge in H-mode or in the plasma core are interpreted as regions with suppressed transport - the ``edge transport barriers.'' Their later ``explanation'' as suppression of turbulence by a sheared rotation was presented as a triumph of the tokamak turbulence theory. The key assumption in existing interpretations of transport phenomena as well as the temperature pedestals is the existence of the perfect magnetic surfaces. In fact, there is no minimal experimental or theory reason for plasma having good magnetic surfaces at the edge. This makes considerations based on such an assumption not credible. Instead of the widespread but baseless assumption, the relaxing of it leads to the understanding of temperature pedestals, consistent with the basic experimental data and free of plasma physics miracles like ``transport barriers.'' This work is supported by US DoE contract No. DE-AC02-09-CH11466.

  8. Competition of individual and institutional punishments in spatial public goods games

    NASA Astrophysics Data System (ADS)

    Szolnoki, Attila; Szabó, György; Czakó, Lilla

    2011-10-01

    We have studied the evolution of strategies in spatial public goods games where both individual (peer) and institutional (pool) punishments are present in addition to unconditional defector and cooperator strategies. The evolution of strategy distribution is governed by imitation based on the random sequential comparison of neighbors’ payoff for a fixed level of noise. Using numerical simulations, we evaluate the strategy frequencies and phase diagrams when varying the synergy factor, punishment cost, and fine. Our attention is focused on two extreme cases describing all the relevant behaviors in such a complex system. According to our numerical data peer punishers prevail and control the system behavior in a large segments of parameters while pool punishers can only survive in the limit of weak peer punishment when a rich variety of solutions is observed. Paradoxically, the two types of punishment may extinguish each other’s impact, resulting in the triumph of defectors. The technical difficulties and suggested methods are briefly discussed.

  9. Werner Heisenberg (1901-1976)

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Werner Heisenberg was one of the greatest physicists of all times. When he started out as a young research worker, the world of physics was in a very confused and frustrating state, which Abraham Pais has described1 as: It was the spring of hope, it was the winter of despair using Charles Dickens' words in A Tale of Two Cities. People were playing a guessing game: There were from time to time great triumphs in proposing, through sheer intuition, make-shift schemes that amazingly explained some regularities in spectral physics, leading to joy. But invariably such successes would be followed by further work which reveal the inconsistency or inadequacy of the new scheme, leading to despair...

  10. The Astrologer's Apparatus: The Material Culture of an Astronomical Specialty in Greek Egypt

    NASA Astrophysics Data System (ADS)

    Evans, J.

    2002-12-01

    While astrology was certainly of Babylonian origin, it was enthusiastically embraced by the Greeks in Egypt, starting in the second century BC. Astrology triumphed because it resonated with many other aspects of Greek culture: astronomy and mathematics, as well as religion and philosophy, magic and mysticism. We have half a dozen Greek and Latin manuals of astrology, written between the first and fifth centuries AD, so we know a lot about the history of astrological doctrine. However, until recently, we have known very little about the social and material circumstances of astrological consultations. Who were the practitioners? Where did they practice? What apparatus did they use? What took place in an astrological consltation? By drawing on a wide range of sources, including literary texts, mathematical papyri, engraved gems, coins, statues and mummy portraits, we can now sketch a very detailed picutre of the professional practice of astrology in Greek Egypt.

  11. Promoting Physics Among Female Learners in the Western Cape Through Active Engagement (abstract)

    NASA Astrophysics Data System (ADS)

    Arendse, Gillian J.

    2009-04-01

    In 2006 the author organized a one-day intervention aimed at promoting physics among female learners at the University of Stellenbosch. The activities included an interactive lecture demonstration promoting active engagement, a hands-on session, and short presentations by female physicists addressing issues such as balancing family and career, breaking the stereotypes, and launching a successful career in physics. Each learner was expected to evaluate the program. In 2007 the author joined forces with Hip2B2 (Shuttleworth Foundation) to host a competition among grade-10 learners with the theme, ``promoting creativity through interactivity.'' The author was tasked by the Hip2B2-team to assist with a program for female learners planned for August 2008, coinciding with our national celebration of Women's Day. The event targeted 160 learners and took place in Durban, East London, Cape Town, and Johannesburg. The author shares some of the learners' experiences and personal triumphs.

  12. Smallpox vaccines: targets of protective immunity.

    PubMed

    Moss, Bernard

    2011-01-01

    The eradication of smallpox, one of the great triumphs of medicine, was accomplished through the prophylactic administration of live vaccinia virus, a comparatively benign relative of variola virus, the causative agent of smallpox. Nevertheless, recent fears that variola virus may be used as a biological weapon together with the present susceptibility of unimmunized populations have spurred the development of new-generation vaccines that are safer than the original and can be produced by modern methods. Predicting the efficacy of such vaccines in the absence of human smallpox, however, depends on understanding the correlates of protection. This review outlines the biology of poxviruses with particular relevance to vaccine development, describes protein targets of humoral and cellular immunity, compares animal models of orthopoxvirus disease with human smallpox, and considers the status of second- and third-generation smallpox vaccines.

  13. Genetic modification of the human germ line: The reasons why this project has no future.

    PubMed

    Morange, Michel

    2015-01-01

    Modification of the human germ line has remained a distant but valuable objective for most biologists since the emergence of genetics (and even before). To study the historical transformations of this project, I have selected three periods - the 1930s, at the pinnacle of eugenics, around 1974 when molecular biology triumphed, and today - and have adopted three criteria to estimate the feasibility of this project: the state of scientific knowledge, the existence of suitable tools, and societal demands. Although the long-awaited techniques to modify the germ line are now available, I will show that most of the expectations behind this project have disappeared, or are considered as being reachable by highly different strategies.

  14. Health care for children from Beveridge to Kennedy: the band plays on.

    PubMed

    Ross, Euan M

    2011-01-01

    The Kennedy report "Getting it Right for Children and Young People: overcoming cultural barriers in the National Health Service so as to meet their need" (2010) can be seen in the context of a long line of reforming reports that include Beveridge (1942), Sheldon (1967) and Court (1976). In the last 60 years perinatal and infant mortality has been greatly reduced and immunisation greatly expanded. Currently, however, despite many triumphs, statistics for the delivery of child health-based services in the UK are not as satisfactory as those in comparable European Union countries. The Kennedy report and the issues it raises are discussed. General practitioners and those who work for them lack training in child health. Child and adolescent mental health services are inadequate. Suggestions for further discussion are made, for example, is there a case for a full integration of child psychiatry and paediatric training? How can postgraduate training for those working in child health services be made more interdisciplinary?

  15. Predictive markers of safety and immunogenicity of adjuvanted vaccines.

    PubMed

    Mastelic, Beatris; Garçon, Nathalie; Del Giudice, Giuseppe; Golding, Hana; Gruber, Marion; Neels, Pieter; Fritzell, Bernard

    2013-11-01

    Vaccination represents one of the greatest public health triumphs; in part due to the effect of adjuvants that have been included in vaccine preparations to boost the immune responses through different mechanisms. Although a variety of novel adjuvants have been under development, only a limited number have been approved by regulatory authorities for human vaccines. This report reflects the conclusions of a group of scientists from academia, regulatory agencies and industry who attended a conference on the current state of the art in the adjuvant field. Held at the U.S. Pharmacopeial Convention (USP) in Rockville, Maryland, USA, from 18 to 19 April 2013 and organized by the International Association for Biologicals (IABS), the conference focused particularly on the future development of effective adjuvants and adjuvanted vaccines and on overcoming major hurdles, such as safety and immunogenicity assessment, as well as regulatory scrutiny. More information on the conference output can be found on the IABS website, http://www.iabs.org/.

  16. A Personal Reflection on the History of Radiation Oncology at Memorial Sloan-Kettering Cancer Center

    SciTech Connect

    Chu, Florence C.H.

    2011-07-01

    Purpose: To provide a historical and personal narrative of the development of radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC), from its founding more than 100 years ago to the present day. Methods and Materials: Historical sources include the Archives of MSKCC, publications by members of MSKCC, the author's personal records and recollections, and her communications with former colleagues, particularly Dr. Basil Hilaris, Dr. Zvi Fuks, and Dr. Beryl McCormick. Conclusions: The author, who spent 38 years at MSKCC, presents the challenges and triumphs of MSKCC's Radiation Oncology Department and details MSKCC's breakthroughs in radiation oncology. She also describes MSKCC's involvement in the founding of the American Society for Therapeutic Radiology and Oncology.

  17. History of corneal transplantation in Australia.

    PubMed

    Coster, Douglas J

    2015-04-01

    Corneal transplantation is a triumph of modern ophthalmology. The possibility of corneal transplantation was first raised in 1797 but a century passed before Zirm achieved the first successful penetrating graft in 1905. Gibson reported the first corneal graft in Australia from Brisbane in 1940 and English established the first eye bank there a few years later. Corneal transplantation evolved steadily over the twentieth century. In the second half of the century, developments in microsurgery, including surgical materials such as monofilament nylon and strong topical steroid drops, accounted for improvements in outcomes. In 2013, approximately 1500 corneal transplants were done in Australia. Eye banking has evolved to cope with the rising demands for donor corneas. Australian corneal surgeons collaborated to establish and support the Australian Corneal Graft Registry in 1985. It follows the outcomes of their surgery and has become an important international resource for surgeons seeking further improvement with the procedure.

  18. Unveiling Cancer

    PubMed Central

    Lakhtakia, Ritu; Burney, Ikram; Qureshi, Asim; Al-Azawi, Sinan; Al-Badi, Hamid; Al-Hajri, Shaikha

    2015-01-01

    This article narrates a multifaceted educational journey undertaken by a medical student through a weekly SCRAPS (surgery, clinical disciplines, radiology, anatomy, psychiatry and laboratory sciences) clinico-pathological meeting held in the College of Medicine & Health Sciences at Sultan Qaboos University in Muscat, Oman. Through a presentation titled ‘Unveiling Cancer’, the multidisciplinary and interprofessional audience witnessed a simulated interaction between a medical student, a technologist peer and tutors in medicine, pathology and radiology. The presentation was based on the complexities of presentation, diagnosis and management of a patient with anaplastic large cell lymphoma, a rare type of non-Hodgkin lymphoma, in the aftermath of a bone marrow transplantation. After describing the case, the student shared with the audience a spectrum of learning objectives, which included integration in the complex world of contemporary medicine, insight into the triumphs and travails of technology (immunohistochemistry) and peer collaboration, communication and mentorship. PMID:26355844

  19. The human face of health disparities.

    PubMed

    Green, Alexander R

    2003-01-01

    In the last 20 years, the issue of disparities in health between racial/ethnic groups has moved from the realm of common sense and anecdote to the realm of science. Hard, cold data now force us to consider what many had long taken for granted. Not only does health differ by race/ethnicity, but our health care system itself is deeply biased. From lack of diversity in the leadership and workforce, to ethnocentric systems of care, to biased clinical decision-making, the American health care system is geared to treat the majority, while the minority suffers. The photos shown here are of patients and scenes that recall some of the important landmarks in research on racial/ethnic disparities in health. The purpose is to put faces and humanity onto the numbers. While we now have great bodies of evidence upon which to lobby for change, in the end, each statistic still represents a personal tragedy or an individual triumph.

  20. Nurses amidst change: the concept of change fatigue offers an alternative perspective on organizational change.

    PubMed

    McMillan, Kim; Perron, Amélie

    2013-02-01

    This article aims to clarify the concept of change fatigue and deems further exploration of the concept within the discipline of nursing is relevant and necessary. The concept of change fatigue has evolved from the discipline of management as a means to explore organization change and its associated triumphs and failures. Change fatigue has typically been described as one and the same as change resistance, with very little literature acknowledging that they are in fact distinct concepts. Concept clarification has highlighted the striking differences and few similarities that exist between the concepts of change fatigue and change resistance. Further exploration and subsequent research on the concept of change fatigue is needed within the discipline of nursing. The concept not only presents new and alternative perspectives on the processes of organization change, but provides opportunity for theory development that recognizes the impact organizational change has on nurses' work lives.

  1. Targeting CD8+ T-cell tolerance for cancer immunotherapy.

    PubMed

    Jackson, Stephanie R; Yuan, Jinyun; Teague, Ryan M

    2014-01-01

    In the final issue of Science in 2013, the American Association of Science recognized progress in the field of cancer immunotherapy as the 'Breakthrough of the Year.' The achievements were actually twofold, owing to the early success of genetically engineered chimeric antigen receptors (CAR) and to the mounting clinical triumphs achieved with checkpoint blockade antibodies. While fundamentally very different, the common thread of these independent strategies is the ability to prevent or overcome mechanisms of CD8(+) T-cell tolerance for improved tumor immunity. Here we discuss how circumventing T-cell tolerance has provided experimental insights that have guided the field of clinical cancer immunotherapy to a place where real breakthroughs can finally be claimed.

  2. Emergency care for older people in India.

    PubMed

    Goel, Ashish

    2013-01-01

    Increasing longevity has been hailed as a triumph of medicine in recent years. With increasing life expectancy all over the world, ageing has been seen to outpace social and economic development in many countries. Declining mortality rates and total fertility rates result in an increase in the proportion of elderly individuals. The impact of the ageing population is felt less in the developed world, and it has been estimated that by the year 2050 over 80% of the elderly world population would be living in the developing world. Despite a higher life expectancy in developing nations, there has also been an increase in the risk of having chronic ailments during the increased years; a reflection of life-long accumulation of risk factors.1.

  3. Uncertain for a century: quantum mechanics and the dilemma of interpretation.

    PubMed

    Frank, Adam

    2015-12-01

    Quantum mechanics, the physical theory describing the microworld, is one of science's greatest triumphs. Remarkably, however, after more than 100 years it is still unclear what quantum mechanics means in terms of basic philosophical questions about the nature of reality. While there are many interpretations of the mathematical machinery of quantum physics, there remain no experimental means to distinguish between most of them. In this contribution, I wish to consider the ways in which the enduring lack of an agreed-upon interpretation of quantum physics influences a number of critical philosophical debates about physics and reality. I briefly review two problems affected by quantum interpretations: the meaning of the term universe and the nature of consciousness.

  4. Seeing Jay-Z in Taipei.

    PubMed

    Hsu, Hua

    2011-01-01

    How does the newly arrived immigrant respond to the news that an identity already awaits him? How does an African American hip-hop artist translate his struggles and triumphs across oceanic divides? What significance do American demographic shifts have in a global context? Hsu's essay examines what happens once individuals or identities migrate beyond the contexts that first produced them. He explores a variety of circuits: the satellite communities of Asian immigrant students who arrived on American university campuses in the late 1960s; enduring debates about a "post-city" identity, spurred by advances in cheap, efficient, world-shrinking communication technologies; and the new affinities and categories of self-identification made possible by a present-day culture that prizes interactivity and participation.

  5. [Iron ore, economic geology and networks of experts between Wisconsin and the state of Minas Gerais, 1881-1914].

    PubMed

    Fischer, Georg

    2014-01-01

    This article deals with the "discovery" of Brazilian iron ore from two perspectives. The first examines the increasing emphasis of the geosciences and their practical application and global reach since the second half of the nineteenth century. While in Brazil economic geology was integrated step by step into state institutions, at the global level it experienced its moment of triumph with the 11th International Geological Congress in 1910. The second deals with a specific social network with a decisive role in the race for Brazilian iron ore: with transnational experts juggling between the logic of the market and that of the academy. The article reveals the importance of local negotiations in the incorporation of the subsoil of Minas Gerais into the global space of mining.

  6. Systems Vaccinology

    PubMed Central

    Pulendran, Bali; Li, Shuzhao; Nakaya, Helder I

    2010-01-01

    Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely ignorant of the mechanisms by which successful vaccines stimulate protective immunity. Two recent advances are beginning to illuminate such mechanisms: realization of the pivotal role of the innate immune system in sensing microbes and stimulating adaptive immunity, and advances in systems biology. Recent studies have used systems biology approaches to obtain a global picture of the immune responses to vaccination in humans. This has enabled the identification of early innate signatures that predict the immunogenicity of vaccines, and identification of potentially novel mechanisms of immune regulation. Here we review these advances, and critically examine the potential opportunities and challenges posed by systems biology in vaccine development. PMID:21029962

  7. The DSM and learning difficulties: formulating a genealogy of the learning-disabled subject.

    PubMed

    Katchergin, Ofer

    2016-06-01

    The article examines the manner in which the learning-disabled subject is created as an object within contemporary psychiatric discourse by means of a genealogical analysis of the learning-disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM). It investigates how this pathology was formed historically in the text, what metamorphoses it underwent, and their epistemic significance. First, the theoretical underpinnings of the sociological discourse on DSM are presented, giving a brief background of the DSM status in the Israeli context. Many problematic characteristics in the text are unveiled, by means of critiques from sociology, anthropology and discourse studies. Second, the changing definitions and conceptualizations of learning-disorders in the seven editions of the Manual and the accompanying case studies (1952-2013) are examined. It becomes apparent that the disorders have undergone changes that have enabled the biomedical paradigm to triumph. The implications of these transformations are addressed.

  8. PRIMARY STROKE PREVENTION IN CHILDREN WITH SICKLE CELL ANEMIA LIVING IN AFRICA: THE FALSE CHOICE BETWEEN PATIENT-ORIENTED RESEARCH AND HUMANITARIAN SERVICE

    PubMed Central

    DEBAUN, MICHAEL R.; GALADANCI, NAJIBAH A.; KASSIM, ADETOLA A.; JORDAN, LORI C.; PHILLIPS, SHARON; ALIYU, MUKTAR H.

    2016-01-01

    In the United States, primary stroke prevention in children with sickle cell anemia (SCA) is now the standard of care and includes annual transcranial Doppler ultrasound evaluation to detect elevated intracranial velocities; and for those at risk, monthly blood transfusion therapy for at least a year followed by the option of hydroxyurea therapy. This strategy has decreased stroke prevalence in children with SCA from approximately 11% to 1%. In Africa, where 80% of all children with SCA are born, no systematic approach exists for primary stroke prevention. The two main challenges for primary stroke prevention in children with SCA in Africa include: 1) identifying an alternative to blood transfusion therapy, because safe monthly blood transfusion therapy is not feasible; and 2) assembling a health care team to implement and expand this effort. We will emphasize early triumphs and challenges to decreasing the incidence of strokes in African children with SCA. PMID:28066035

  9. Clinical vaccine development

    PubMed Central

    2015-01-01

    Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge and the investment of massive funding have enabled the development of vaccines against many infectious diseases as well as other diseases including malignant tumors. The paradigm of clinical vaccine evaluation and licensure has also been modernized based on scientific improvements and historical experience. However, there remain a number of hurdles to overcome. Continuous efforts are focused on increasing the efficacy and reducing the risks related to vaccine use. Cutting-edge knowledge about immunology and microbiology is being rapidly translated to vaccine development. Thus, physicians and others involved in the clinical development of vaccines should have sufficient understanding of the recent developmental trends in vaccination and the diseases of interest. PMID:25648742

  10. Say What? The Role of Audio in Multimedia Video

    NASA Astrophysics Data System (ADS)

    Linder, C. A.; Holmes, R. M.

    2011-12-01

    Audio, including interviews, ambient sounds, and music, is a critical-yet often overlooked-part of an effective multimedia video. In February 2010, Linder joined scientists working on the Global Rivers Observatory Project for two weeks of intensive fieldwork in the Congo River watershed. The team's goal was to learn more about how climate change and deforestation are impacting the river system and coastal ocean. Using stills and video shot with a lightweight digital SLR outfit and audio recorded with a pocket-sized sound recorder, Linder documented the trials and triumphs of working in the heart of Africa. Using excerpts from the six-minute Congo multimedia video, this presentation will illustrate how to record and edit an engaging audio track. Topics include interview technique, collecting ambient sounds, choosing and using music, and editing it all together to educate and entertain the viewer.

  11. Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

    PubMed

    Livingstone, David N

    2015-09-01

    Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

  12. Outline of a failure: a true story of nine precepts, with two morals

    SciTech Connect

    Stevens, D.F.

    1985-08-01

    This is not a conventional case history. It is concerned with failure rather than with triumph, and further, with a personal definition of failure. Failure, like beauty, is in the eye of the beholder. The system I shall call SOS, when measured in terms of absolute achievement, might not be considered a failure. When measured against corporate plans and goals it might not be admitted to be a failure. But when measured against some aspects of the state-of-the-art it professed to advance, against fundamental ergonomic principles, and, especially, against its potential, it was a failure. Specifically, it failed to meet the expectations of one user. It is only fair, then, to begin by characterizing those expectations and giving some indication of their sources. Then follow five sections on various classes of failure. (The Precepts of the title are embedded in these sections.) The paper concludes with a brief discussion of the Two Morals.

  13. A new synthesis in search of synthesizing agents Comment on “A new synthesis”

    PubMed Central

    Grignon, Michel

    2014-01-01

    In a recent editorial in this journal Pierre-Gerlier Forest foretells a coming revolution in health policy based on the synthesis of four conceptual innovations and one technological breakthrough. As much as I agree with the intellectual story told in this editorial I present a more skeptical view of the effect of paradigm shifts on healthcare systems on the ground. I argue that ideas triumph when times are ripe and times are ripe in health policy when payers and providers can find a compromise between the need to value what providers do and their professional autonomy. I also argue that autonomy is a product of the market: patients value autonomy and prefer doctors to insurers. PMID:24757692

  14. Ancient Chinese medical ethics and the four principles of biomedical ethics.

    PubMed Central

    Tsai, D F

    1999-01-01

    The four principles approach to biomedical ethics (4PBE) has, since the 1970s, been increasingly developed as a universal bioethics method. Despite its wide acceptance and popularity, the 4PBE has received many challenges to its cross-cultural plausibility. This paper first specifies the principles and characteristics of ancient Chinese medical ethics (ACME), then makes a comparison between ACME and the 4PBE with a view to testing out the 4PBE's cross-cultural plausibility when applied to one particular but very extensive and prominent cultural context. The result shows that the concepts of respect for autonomy, non-maleficence, beneficence and justice are clearly identifiable in ACME. Yet, being influenced by certain socio-cultural factors, those applying the 4PBE in Chinese society may tend to adopt a "beneficence-oriented", rather than an "autonomy-oriented" approach, which, in general, is dissimilar to the practice of contemporary Western bioethics, where "autonomy often triumphs". PMID:10461594

  15. Teaching Through Tolkien: The Astronomy of Middle-earth

    NASA Astrophysics Data System (ADS)

    Larsen, Kristine

    2004-03-01

    ``The Hobbit,'' ``The Lord of the Rings,'' and others of J.R.R. Tolkien's classic fantasy tales have delighted readers for decades. Tolkien was careful to include scientific details in his work, in an attempt to add depth and realism to his mythological creation, Middle-earth. For example, he invented numerous constellations, some of which correspond well with actual star groupings, others of which remain a mystery to Tolkien scholars (and astronomers) to this day. The internal chronology of ``The Lord of the Rings'' was timed to the cycle of lunar phases. In more obscure writings, Tolkien described a mythological beginning for the moon which closely mirrored the actual scientific theory of the day, the ``fission theory'' of G.H. Darwin. Bringing to light these and others of his scientific triumphs (and blunders) through class discussions and laboratory exercises is a creative and timely way to demonstrate the interdisciplinary relevance of science (especially astronomy) to non-science majors.

  16. An historical, biographical, literary, and clinical consideration of Freud's 'Analysis Terminable and Interminable' on its fiftieth birthday.

    PubMed

    Loewenberg, P

    1988-01-01

    Freud's paper is re-examined and placed in biographical and historical context, Moses and monotheism (1934-1938) is treated as a parallel text. Freud's ironic scepticism is viewed against the background of Thomas Mann's 1936 idealization of psychoanalysis. Freud was a sick and dying man in 1937 with every reason for personal pessimism. The political setting was the triumph of fascism in Austria and the impending seizure of Austria by Hitler. Freud fantasized the protection of psychoanalysis by the Roman Catholic Church. The paper is a polemic against the theories of Ferenczi, Adler, and Rank. Contemporaneous defence of prophylactic analysis by Fenichel is reviewed. Freud's political judgement of the moral equivalence of Social Democracy and fascism is critiqued. Freud's injunction to periodic re-analysis and his vision of analysis as 'unending' is supported. The possibility of intergenerational prophylaxis is presented.

  17. Using 2nd generation tyrosine kinase inhibitors in frontline management of chronic phase chronic myeloid leukemia

    PubMed Central

    Jayakar, Vishal

    2014-01-01

    Choices in medicine come with responsibility. With several TKI's (Tyrosine kinase inhibitors) available for front-line management of CML (Chronic Myeloid Leukemia), an astute clinician has to personalise, rationalise and take a pragmatic approach towards selection of the best drug for the ‘patient in question’. Though it is hotly debated as to which TKI will triumph, the truth of this debate lies in individualising treatment rather than a general ‘all size fits all’ approach with imatinib. I personally believe that the second generation TKI's will suit most patient clinical profiles rather than prescribing imatinib to all and I have strived to make a strong case for them in front line treatment of CML. Though Imatinib may remain the first line choice for some patients, my efforts in this debate are mainly geared towards breaking the myth that imatinib is the sole ‘block buster’ on the CML landscape PMID:24665456

  18. Robot Design

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Martin Marietta Aero and Naval Systems has advanced the CAD art to a very high level at its Robotics Laboratory. One of the company's major projects is construction of a huge Field Material Handling Robot for the Army's Human Engineering Lab. Design of FMR, intended to move heavy and dangerous material such as ammunition, was a triumph in CAD Engineering. Separate computer problems modeled the robot's kinematics and dynamics, yielding such parameters as the strength of materials required for each component, the length of the arms, their degree of freedom and power of hydraulic system needed. The Robotics Lab went a step further and added data enabling computer simulation and animation of the robot's total operational capability under various loading and unloading conditions. NASA computer program (IAC), integrated Analysis Capability Engineering Database was used. Program contains a series of modules that can stand alone or be integrated with data from sensors or software tools.

  19. The Immortal Fire Within

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2007-12-01

    Preface; Key to abbreviations in notes; 1. Through rugged ways; 2. Ardent and faithful work with a telescope; 3. Mars; his moons and his heavens; 4. A seeker of comets; 5. Vanderbilt astronomer; 6. In the realm of the nebulae; 7. Go west, young man!; 8. Hanging fire; 9. On Mt. Hamilton; 10. A year of wonders; 11. The young rebel; 12. 'I am tired here'; 13. Immortality; 14. Travels and travails; 15. Barnard and Mars; 16. Nature's true artisan; 17. A tide in his affairs; 18. Yerkes observatory; 19. Disappointments and triumphs; 20. The comet and Milky Way photographs; 21. Comet tales; 22. Observer of all that shines - or obscures; 23. Eclipse and decline; 24. Ad astra; Index.

  20. Space Systems Failures: Disasters and Rescues of Satellites, Rocket and Space Probes

    NASA Astrophysics Data System (ADS)

    Harland, David M.; Lorenz, Ralph

    In the 1960s and 1970s deep space missions were dispatched in pairs in case one was lost in launch or failed during its journey. Following the triumphs of the Viking landings on Mars in 1976 and both Voyagers spacecraft successfully surveying the outer giant planets of the Solar System, it was decided by NASA to cut costs and send out just a single probe. Although Magellan successfully mapped Venus by radar, it suffered from problems during the flight. Then came the loss of Mars Observer, whose engine exploded as it was preparing to enter Mars' orbit because it was using technology designed for Earth's satellites and the engine was not suited to spending several months in space.

  1. The Teaching of Physics in Cuba from Colonial Times to 1959

    NASA Astrophysics Data System (ADS)

    Altshuler, José; Baracca, Angelo

    The present paper will concentrate on the study of the first one and a half centuries of the teaching of physics in Cuba, starting from the early interest or activities in this. To provide the appropriate context, we will begin by going back in time to the early local signs of a modern scientific sensitivity, scornful of scholastic teaching and fond of experimental approaches, under the belated but stimulating influence of the European Enlightenment. We will go over individual cases during the initial phase of the country's academic physics in some detail, firstly during the initial period of colonial rule, and then from the beginning of the twentieth century to the triumph of the 1959 Revolution earlier that year. We thus hope to make the fundamental aspects of our subject reasonably consistent and abiding, even though further historical research may eventually throw new light on relevant details, personalities and events.

  2. The evolution of fungal morphogenesis, a personal account.

    PubMed

    Bartnicki-Garcia, Salomon

    2016-01-01

    This article describes the evolution of the field of fungal morphogenesis, its beginning at the end of the 19th century and its exponential growth during the second half of the 20th century, continuing until the present day. The main theme correlates biological progress with the advent of new technologies. Accordingly the article describes the discovery of apical growth, the fibrillar nature of the fungal wall, the chemistry of the cell wall, the search for biochemical pathways in morphogenesis, the discovery of the Spitzenkörper, the apical gradient of wall synthesis, key highlights in ultrastructural research, the development of mathematical models particularly the vesicle supply center (VSC) model, the revolution brought about by molecular biology and unique discoveries such as the hydrophobins and γ-tubulin and some the latest triumphs of the marriage between molecular genetics and confocal microscopy. Credit is given to the investigators responsible for all the advances.

  3. Small(pox) success?

    PubMed

    Birn, Anne-Emanuelle

    2011-02-01

    The 30th anniversary of the World Health Organization's (WHO) official certification of smallpox eradication was marked by a slew of events hailing the campaign's dramatic tale of technological and organizational triumph against an ancient scourge. Yet commemorations also serve as moments of critical reflection. This article questions the acclaim showered upon smallpox eradication as the single greatest public health success in history. It examines how and why smallpox eradication and WHO's concurrent social justice-oriented primary health care approach (following from the Declaration of Alma-Ata) became competing paradigms. It synthesizes critiques of eradication's shortcomings and debunks some of the myths surrounding the global eradication campaign as a public health priority and necessity, and as a Cold War victory of cooperation. The article concludes with thoughts on integrating technical and social-political aspects of health within the context of welfare states as the means to achieving widespread and enduring global public health success.

  4. Gravitational Lensing

    SciTech Connect

    Lincoln, Don

    2015-06-24

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  5. In Appreciation Julian Schwinger: From Nuclear Physics and Quantum Electrodynamics to Source Theory and Beyond

    NASA Astrophysics Data System (ADS)

    Milton, Kimball A.

    2007-01-01

    Julian Schwinger’s influence on twentieth-century science is profound and pervasive. He is most famous for his renormalization theory of quantum electrodynamics, for which he shared the Nobel Prize in Physics for 1965 with Richard Feynman and Sin-itiro Tomonaga. This triumph undoubtedly was his most heroic work, but his legacy lives on chiefly through subtle and elegant work in classical electrodynamics, quantum variational principles, proper-time methods, quantum anomalies, dynamical mass generation, partial symmetry, and much more. Starting as just a boy, he rapidly became one of the preeminent nuclear physicists in the world in the late 1930s, led the theoretical development of radar technology at the Massachusetts Institute of Technology during World War II, and soon after the war conquered quantum electrodynamics, becoming the leading quantum-field theorist for two decades, before taking a more iconoclastic route during the last quarter century of his life.

  6. A forgotten social science? Creating a place for linguistics in the historical dialogue.

    PubMed

    Martin-Nielsen, Janet

    2011-01-01

    The post-World War II era was one of great triumph for American linguists-and yet linguistics is all but absent from the historical literature on postwar social science. This paper aims to illuminate this curious situation: to understand its provenance, evaluate its merits, and contextualize it broadly. I argue that the historiographic lacuna results from two factors: (1) the opt-out of linguists from the wider American social science community, and (2) historical-developmental and -orientational factors that stand linguistics apart from the social science mainstream. The resultant isolation of linguistics has led to a parallel isolation in the historical literature. Ultimately, this paper poses a pivotal and timely question: How is the postwar social science space construed within the existing historiographic framework, and how should it be construed in order to maximize understanding? I propose a rethink of the received historiography centered on intellectual transformations and cross-disciplinary integration.

  7. Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala.

    PubMed

    Han, Wenfei; Tellez, Luis A; Rangel, Miguel J; Motta, Simone C; Zhang, Xiaobing; Perez, Isaac O; Canteras, Newton S; Shammah-Lagnado, Sara J; van den Pol, Anthony N; de Araujo, Ivan E

    2017-01-12

    Superior predatory skills led to the evolutionary triumph of jawed vertebrates. However, the mechanisms by which the vertebrate brain controls predation remain largely unknown. Here, we reveal a critical role for the central nucleus of the amygdala in predatory hunting. Both optogenetic and chemogenetic stimulation of central amygdala of mice elicited predatory-like attacks upon both insect and artificial prey. Coordinated control of cervical and mandibular musculatures, which is necessary for accurately positioning lethal bites on prey, was mediated by a central amygdala projection to the reticular formation in the brainstem. In contrast, prey pursuit was mediated by projections to the midbrain periaqueductal gray matter. Targeted lesions to these two pathways separately disrupted biting attacks upon prey versus the initiation of prey pursuit. Our findings delineate a neural network that integrates distinct behavioral modules and suggest that central amygdala neurons instruct predatory hunting across jawed vertebrates.

  8. Psychiatry and neurology: from dualism to integration.

    PubMed

    Sobański, Jerzy A; Dudek, Dominika

    2013-01-01

    The two objectives of the following paper are: to make few remarks on the topic absorbing neurologists, psychiatrists, and neuropsychiatrists - integration and division of their specialties; and to describe the situation in Poland, reflected in the latest literature. The authors describe the former and present processes of approaches and divisions in psychiatry and neurology. They indicate dissemination of mutual methods of structural and action brain neuroimaging, neurophysiology, neurogenetics, and advanced neurophysiology diagnostics. As it seems, even the effectiveness of psychotherapy, has recently been associated with changes in brain in functional and even structural markers. The authors indicate the value of the strive to join the still divided specialties, reflected worldwide in attempts of common education and clinical cooperation of physicians. It can be expected that subsequent years will bring further triumphs of neuropsychiatry - a field that combines psychiatry and neurology.

  9. Gravitational Lensing

    ScienceCinema

    Lincoln, Don

    2016-07-12

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  10. Do current beliefs predict hypomanic symptoms beyond personality style? Factor analysis of the hypomanic attitudes and positive predictions inventory (HAPPI) and its association with hypomanic symptoms in a student population.

    PubMed

    Mansell, Warren; Rigby, Zoe; Tai, Sara; Lowe, Christine

    2008-04-01

    A self-report scale called the Hypomanic Attitudes and Positive Predictions Inventory (HAPPI) has been developed to assess cognitions that distinguish between bipolar disorder and nonclinical controls (Mansell, 2006; Mansell & Jones, 2006). We recruited 191 undergraduate students to assess the associations between the HAPPI and self-reported past (MDQ; Hirschfeld et al., 2000) and present (ISS; Bauer et al., 1991) bipolar symptoms, and to explore the factor structure of the scale. The HAPPI correlated with past and present symptoms independently of the BIS/BAS subscales (Carver & White, 1994) and the HPS (Eckblad & Chapman, 1986). Five factors of the HAPPI were identified: success activation and triumph over fear, activating response style, reduced social regulation, loss of control when activated, and catastrophic beliefs about internal states. The HAPPI factors showed specific relationships with current bipolar symptoms that largely fitted with predictions based on the model. Further work is required to establish whether they have a causal role.

  11. Gene therapy: progress in childhood disease.

    PubMed

    Ginn, Samantha L; Alexander, Ian E

    2012-06-01

    The recent sequencing of the human genome combined with the development of massively high throughput genetic analysis technologies is driving unprecedented growth in our knowledge of the molecular basis of disease. While this has already had a major impact on our diagnostic power, the therapeutic benefits remain largely unrealised. This review examines progress in the exciting and challenging field of gene therapy. In particular we focus on the treatment of genetic disease in infants and children where the most significant successes have been observed to date, despite the majority of trial participants being adults. Notably, gene transfer to the haematopoietic compartment has provided the clearest examples of therapeutic benefit, particularly in the context of primary immunodeficiencies. The triumphs and tribulations of these successes are explored, and the key challenges confronting researchers as they seek to further advance the field are defined and discussed.

  12. Clever Hans and his effects: Karl Krall and the origins of experimental parapsychology in Germany.

    PubMed

    De Sio, Fabio; Marazia, Chantal

    2014-12-01

    Shortly before the outbreak of World War I, the so-called Elberfeld horses, the counting and speaking animals, were among the most debated subjects of the newborn comparative psychology. Yet, they have left little trace in the historiography of this discipline, mostly as an appendix of the more famous Clever Hans. Their story is generally told as the prelude to the triumph of reductionistic experimental psychology. By paying a more scrupulous attention than has so far being done to the second life of Hans, and to the endeavours of his second master, Karl Krall, this article explores the story of the Elberfeld horses as an important, if so far neglected, chapter in the history of experimental parapsychology.

  13. Toward a Brighter Future for Psychology as an Observation Oriented Science

    PubMed Central

    Grice, James W.; Barrett, Paul T.; Schlimgen, Liz A.; Abramson, Charles I.

    2012-01-01

    Serious criticisms of psychology’s research practices and data analysis methods date back to at least the mid-1900s after the Galtonian school of thought had thoroughly triumphed over the Wundtian school. In the wake of Bem’s (2011) recent, highly publicized study on psi phenomena in a prestigious journal, psychologists are again raising serious questions about their dominant research script. These concerns are echoed in the current paper, and Observation Oriented Modeling (OOM) is presented as an alternative approach toward data conceptualization and analysis for the social and life sciences. This approach is rooted in philosophical realism and an attitude toward data analysis centered around causality and common sense. Three example studies and accompanying data analyses are presented and discussed to demonstrate a number of OOM’s advantages over current researcher practices. PMID:25379212

  14. Mathemimetics II. Demonstratio Mirabilis of FLT by infinitely ascending cubical crystal growth

    NASA Astrophysics Data System (ADS)

    Trell, Erik

    2012-09-01

    Emulating Nature by observation and ground-up application of its patterns, structures and processes is a classical scientific practice which under the designation of Biomimetics has now been brought to the Nanotechnology scale where even highly complex systems can be realized by continuous or cyclically reiterated assembly of the respective self-similar eigen-elements, modules and algorithms right from their infinitesimal origin. This is actually quite akin to the genuine mathematical art and can find valuable renewed use as here exemplified by the tentatively original Demonstratio Mirabilis of FLT (Fermat's Last Theorem, or, in that case, Triumph) by infinitely ascending sheet-wise cubical crystal growth leading to the binomial `magic triangle' of his close fellow Blaise Pascal.

  15. Geology and mineral deposits of the Minnie Moore and Bullion mineralized areas, Blaine County, Idaho

    USGS Publications Warehouse

    Link, Paul Karl; Worl, Ronald G.

    2001-01-01

    In the early 1880?s the discovery of rich ores in the Minnie Moore and Bullion mineralized areas sparked a rush to settle and develop the Wood River valley. Silver and lead discoveries in these areas spurred the boom in mining after completion of the Oregon Short Line Railroad to Hailey in 1883. In both areas the ore comprises galena, sphalerite, and tetrahedrite in a gangue of siderite, calcite, or quartz. Minor goldbearing quartz veins are also present. The ore is in fissure and replacement veins along fracture systems that formed in Late Cretaceous time, after intrusion of nearby granodiorite or quartz diorite stocks. The ore formed under mesothermal conditions and heat was supplied by the nearby plutons. In the Minnie Moore area, the mineralized veins are cut by low-angle normal faults that are of probable Eocene age. In the Minnie Moore mineralized area, the host rock is the middle part of the Devonian Milligen Formation, (the informal Lucky Coin limestone and Triumph argillite), which is the same stratigraphic level as the host ore in the rich Triumph mine northeast of Hailey. In the Bullion mineralized area, the ore is hosted by the lower member of the Middle Pennsylvanian to Lower Permian Dollarhide Formation. Rich ore was mined in several tunnels that reached the Mayflower vein, a northwest-striking mineralized shear zone. The deposits are thought to be mainly mesothermal veins that formed in association with Cretaceous magmatism. The syngenetic stratiform model of ore formation has often been applied to these deposits, however, no evidence of syngenetic mineralization was found in this study. Faulting has displaced most of the major orebodies and thus has made mining these deposits a challenge.

  16. Release and Activity of Bound beta-Amylase in a Germinating Barley Grain.

    PubMed

    Sopanen, T; Laurière, C

    1989-01-01

    In resting grains of Triumph barley (Hordeum vulgare L. cv Triumph) about 40% of the beta-amylase could be extracted with a saline solution, the remaining 60% being in a bound form. During seedling growth (20 degrees C), the bound form was released mainly between days 1 and 3. When a preparation containing bound beta-amylase was incubated with an extract made of endosperms separated from germinating grains, release of bound beta-amylase took place and could be studied in vitro. The release was almost completely prevented by leupeptin and antipain, specific inhibitors of a group of SH-proteinases, but it was not inhibited by pepstatin A or EDTA, which inhibit some other barley proteinases. It is thus very likely that in a whole grain, at least the bulk of the bound beta-amylase is released by the proteolytic action of one or several SH-proteinases. When the bound beta-amylase was released by papain, its molecular weight was about 5000 daltons smaller than that of beta-amylase released by dithiothreitol. This indicates that the release is due to removal of a sequence of beta-amylase itself. A similar decrease in size took place during seedling growth. Bound beta-amylase showed some activity against native starch and it hydrolyzed maltotetraose at a rate that was about 70% of the rate the same amount of bound beta-amylase gave after release. Bound beta-amylase is thus not inactive and it is likely that the slower rate of hydrolysis is due to steric hindrances which prevent substrates from reaching the active site.

  17. AIDS and transfer factor: myths, certainties and realities.

    PubMed

    Viza, D

    1996-01-01

    At the end of the 20th century, the triumph of biology is as indisputable as that of physics was at the end of the 19th century, and so is the might of the inductive thought. Virtually all diseases have been seemingly conquered and HIV, the cause of AIDS, has been fully described ten years after the onset of the epidemic. However, the triumph of biological science is far from being complete. The toll of several diseases, such as cancer, continues to rise and the pathogenesis of AIDS remains elusive. In the realm of inductive science, the dominant paradigm can seldom be challenged in a frontal attack, especially when it is apparently successful, and only what Kuhn calls "scientific revolutions" can overthrow it. Thus, it is hardly surprising that the concept of transfer factor is considered with contempt, and the existence of the moiety improbable: over forty years after the introduction of the concept, not only its molecular structure remains unknown, but also its putative mode of action contravenes dogmas of both immunology and molecular biology. And when facts challenge established dogmas, be in religion, philosophy or science, they must be suppressed. Thus, results of heterodox research become henceforth nisi-i.e., valid unless cause is shown for rescinding them, because they challenge the prevalent paradigm. However, when observations pertain to lethal disorders, their suppression in the name of dogmas may become criminal. Because of the failure of medical science to manage the AIDS pandemic, transfer factor, which has been successfully used for treating or preventing viral infections, may today overcome a priori prejudice and rejection more swiftly. In science, as in life, certainties always end up by dying, and Copernicus' vision by replacing that of Ptolemy.

  18. Space Geodesy Monitoring Mass Transport in Global Geophysical Fluids

    NASA Technical Reports Server (NTRS)

    Chao, Benjamin F.

    2004-01-01

    Mass transports occurring in the atmosphere-hydrosphere-cryosphere-solid Earth-core system (the 'global geophysical fluids') are important geophysical phenomena. They occur on all temporal and spatial scales. Examples include air mass and ocean circulations, oceanic and solid tides, hydrological water and idsnow redistribution, mantle processes such as post-glacial rebound, earthquakes and tectonic motions, and core geodynamo activities. The temporal history and spatial pattern of such mass transport are often not amenable to direct observations. Space geodesy techniques, however, have proven to be an effective tool in monitorihg certain direct consequences of the mass transport, including Earth's rotation variations, gravitational field variations, and the geocenter motion. Considerable advances have been made in recent years in observing and understanding of these geodynamic effects. This paper will use several prominent examples to illustrate the triumphs in research over the past years under a 'Moore's law' in space geodesy. New space missions and projects promise to further advance our knowledge about the global mass transports. The latter contributes to our understanding of the geophysical processes that produce and regulate the mass transports, as well as of the solid Earth's response to such changes in terms of Earth's mechanical properties.

  19. Mathematical Modelling of Allelopathy: IV. Assessment of Contributions of Competition and Allelopathy to Interference by Barley.

    PubMed

    Liu, De Li; An, Min; Johnson, I R; Lovett, J V

    2005-04-01

    One of the main challenges to the research on allelopathy is technically the separation of allelopathic effect from competition, and quantitatively, the assessment of the contribution of each component to overall interference. A simple mathematical model is proposed to calculate the contribution of allelopathy and competition to interference. As an example of applying the quantitative model to interference by barley (Hordeum vulgare cv. Triumph), the approach used was an addition of allelopathic effect, by an equivalent amount, to the environment of the test plant (white mustard, Sinapis alba), rather than elimination of competition. Experiments were conducted in glasshouse to determine the magnitude of the contributions of allelopathy and competition to interference by barley. The leachates of living barley roots significantly reduced the total dry weight of white mustard. The model involved the calculation of adjusted densities to an equivalent basis for modelling the contribution of allelopathy and competition to total interference. The results showed that allelopathy contributed 40%, 37% and 43% to interference by barley at 6, 12 and 18 white mustard pot(-1). The consistency in magnitude of the calculated contribution of allelopathic effect by barley across various densities of receiver plant suggested that the adjusted equivalent density is effective and that the model is able to assess the contribution of each component of interference regardless of the density of receiver plant.

  20. Mathematical Modelling of Allelopathy: IV. Assessment of Contributions of Competition and Allelopathy to Interference by Barley

    PubMed Central

    Liu, De Li; An, Min; Johnson, I.R.; Lovett, J.V.

    2005-01-01

    One of the main challenges to the research on allelopathy is technically the separation of allelopathic effect from competition, and quantitatively, the assessment of the contribution of each component to overall interference. A simple mathematical model is proposed to calculate the contribution of allelopathy and competition to interference. As an example of applying the quantitative model to interference by barley (Hordeum vulgare cv. Triumph), the approach used was an addition of allelopathic effect, by an equivalent amount, to the environment of the test plant (white mustard, Sinapis alba), rather than elimination of competition. Experiments were conducted in glasshouse to determine the magnitude of the contributions of allelopathy and competition to interference by barley. The leachates of living barley roots significantly reduced the total dry weight of white mustard. The model involved the calculation of adjusted densities to an equivalent basis for modelling the contribution of allelopathy and competition to total interference. The results showed that allelopathy contributed 40%, 37% and 43% to interference by barley at 6, 12 and 18 white mustard pot−1. The consistency in magnitude of the calculated contribution of allelopathic effect by barley across various densities of receiver plant suggested that the adjusted equivalent density is effective and that the model is able to assess the contribution of each component of interference regardless of the density of receiver plant. PMID:19330162

  1. How are they doing? Listening as fathers of children with autism spectrum disorder compare themselves to fathers of children who are typically developing.

    PubMed

    Cheuk, Samantha; Lashewicz, Bonnie

    2016-04-01

    The growing prevalence of autism spectrum disorder is accompanied by ongoing efforts to understand and support parents in the face of challenges related to their child's autism spectrum disorder. Although fathers are increasingly hands-on in raising children, research focus on parenting children with autism spectrum disorder continues to be skewed toward experiences of mothers. Our purpose in this article is to contribute understandings of how fathers of children with autism spectrum disorder perceive themselves to be managing, and we undertake this by examining comparisons fathers of children with autism spectrum disorder make between their parenting experiences and experiences of fathers of typically developing children. A purposive sample of 28 fathers of children (aged 2-13 years) with autism spectrum disorder living in an urban center in Western Canada participated in in-depth interviews about their parenting successes and challenges. We found fathers speak of universal fathering experiences yet articulate their own sense of loss and efforts to come to terms with unanticipated demands associated with autism spectrum disorder. Fathers of children with autism spectrum disorder feel "pangs of jealousy" toward fathers of typically developing children, yet they are keenly attentive to their own child's development and convey a sense of gratitude for their child's capabilities and personality amidst an appreciation for trials and triumphs of fathering in general and fathering a child with autism spectrum disorder in particular.

  2. Global environmental politics: Lessons from Montreal

    SciTech Connect

    Kauffman, J. )

    1994-01-01

    When 24 nations and the European Community signed the Montreal Protocol in September, 1987, it was widely praised for its reflection of unprecedented foresight in mandating preventive action on a global scale. Such praise may have been premature in light of more recent revelations that: (1) the rates of ozone depletion appear to be accelerating; and (2) the depletion seems to be spreading into the summer months over the north temperate zone of latitudes. Although there is still controversy over what the effects of such depletion ultimately will be, most nations of the world, including all of the advanced industrialized countries, agree that chlorofluorocarbons (CFCs) must be phased out of all production and use, and they are taking steps to do that before the turn of the century. Two distinctly different conclusions are thus possible regarding the outcome of the negotiations. As the first successfully negotiated multilateral agreement to address a global environmental problem, the Protocol is seen by many to be a triumph of environmental awareness and international cooperation. To other observers, however, the struggle for domestic commercial interests and national political debates that led to delays in action may already be causing serious and irreversible damage that could have been avoided. In short, the negotiation process worked, but it took to long for nations to agree that it was necessary and to begin the process.

  3. Stapp`s quantum dualism: The James/Heisenberg model of consciousness

    SciTech Connect

    Noyes, H.P.

    1994-02-18

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James` description of conscious events and for matter from Werner Heisenberg`s ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author`s opinion fails to establish a monistic, scientific theory. The author traces Stapp`s failure to his adamant rejection of arbitrariness, or `randomness`. This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin`s explanation of biology, let along the triumphs of modern `neo-Darwinism`. The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp`s views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy.

  4. Donor wave functions in Si gauged by STM images

    NASA Astrophysics Data System (ADS)

    Saraiva, A. L.; Salfi, J.; Bocquel, J.; Voisin, B.; Rogge, S.; Capaz, Rodrigo B.; Calderón, M. J.; Koiller, Belita

    2016-01-01

    The triumph of effective mass theory in describing the energy spectrum of dopants does not guarantee that the model wave functions will withstand an experimental test. Such wave functions have recently been probed by scanning tunneling spectroscopy, revealing localized patterns of resonantly enhanced tunneling currents. We show that the shape of the conducting splotches resembles a cut through Kohn-Luttinger (KL) hydrogenic envelopes, which modulate the interfering Bloch states of conduction electrons. All the nonmonotonic features of the current profile are consistent with the charge density fluctuations observed between successive {001 } atomic planes, including a counterintuitive reduction of the symmetry—a heritage of the lowered point group symmetry at these planes. A model-independent analysis of the diffraction figure constrains the value of the electron wave vector to k0=(0.82 ±0.03 ) (2 π /aSi) . Unlike prior measurements, averaged over a sizable density of electrons, this estimate is obtained directly from isolated electrons. We further investigate the model-specific anisotropy of the wave function envelope, related to the effective mass anisotropy. This anisotropy appears in the KL variational wave function envelope as the ratio between Bohr radii b /a . We demonstrate that the central-cell-corrected estimates for this ratio are encouragingly accurate, leading to the conclusion that the KL theory is a valid model not only for energies but for wave functions as well.

  5. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    DOE PAGES

    Friedemann, S.; Chang, H.; Gamża, M. B.; ...

    2016-05-12

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate ofmore » the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. We find our results point at a large Fermi surface consistent with Luttinger's theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition.« less

  6. Alpha-1 antitrypsin augmentation therapy.

    PubMed

    Wewers, Mark D; Crystal, Ronald G

    2013-03-01

    The therapy of alpha-1 antitrypsin deficiency (AATD) is an example of a medical triumph over a common hereditary disease. Based on the understanding of the pathogens of the disease as a deficiency in liver production of alpha-1 antitrypsin (AAT) resulting from inherited genetic variation in both parental AAT genes, the knowledge that A1AT functions primarily to inhibit neutrophil elastase (NE), and the observation that NE instilled into the lung of experimental animals resulted in emphysema, the concept evolved that the pulmonary manifestations of the disease could be halted by intermittent intravenous infusions of AAT purified from pooled human plasma. Following preliminary clinical studies in the academic community, and then pharmaceutical company development of large scale purification of human AAT, the FDA approved the use of weekly AAT augmentation therapy for AATD following a clinical trial which demonstrated that weekly infusions would raise to normal plasma and lung epithelial fluid levels of AAT in AAT-deficient individuals. The therapy is now used worldwide to treat AATD, the only pulmonary genetic disease with effective therapy for all affected individuals.

  7. Multielemental analysis of tissues from Cangrande della Scala, Prince of Verona, in the 14th century.

    PubMed

    Apostoli, Pietro; De Palma, Giuseppe; Catalani, Simona; Bortolotti, Federica; Tagliaro, Franco

    2009-01-01

    Cangrande della Scala, Prince of Verona (Italy), died suddenly shortly after his triumph in the battle of Treviso (July 18, 1329). Thus, in the frame of a multidisciplinary paleo-pathological study, we carried out a multielemental analysis on the Prince's tissue specimens, including hair, liver, muscle, and bone, in order to characterize a multitissue profile of metallic elements in a nobleman of the 14th century. Biological specimens were analyzed by inductively coupled plasma-mass spectrometry. We were able to rule out arsenic poisoning as the primary cause of death. High levels of gold and silver in both hair and liver samples were probably due to prolonged contact of the mummy with precious metals in the funeral garments. High lead concentrations in both liver and bone tissue can be traced back to the ingestion of contaminated food and alcoholic beverages. Most of the essential elements were in the normal range of values for contemporary living people. The low arsenic and chromium levels in the Prince's tissues as compared to modern people would be suggestive of raised concentrations of both the elements in the present era, which are likely due to industrial pollution.

  8. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    PubMed Central

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-01-01

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. Our results point at a large Fermi surface consistent with Luttinger’s theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition. PMID:27174799

  9. There ain't nothing like a Dame: a commentary on Lonsdale (1947) ‘Divergent beam X-ray photography of crystals’

    PubMed Central

    Glazer, A. M.

    2015-01-01

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon–carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750139

  10. Molecular beam brightening by shock-wave suppression

    PubMed Central

    Segev, Yair; Bibelnik, Natan; Akerman, Nitzan; Shagam, Yuval; Luski, Alon; Karpov, Michael; Narevicius, Julia; Narevicius, Edvardas

    2017-01-01

    Supersonic beams are a prevalent source of cold molecules used in the study of chemical reactions, atom interferometry, gas-surface interactions, precision spectroscopy, molecular cooling, and more. The triumph of this method emanates from the high densities produced in relation to other methods; however, beam density remains fundamentally limited by interference with shock waves reflected from collimating surfaces. We show experimentally that this shock interaction can be reduced or even eliminated by cryocooling the interacting surface. An increase of nearly an order of magnitude in beam density was measured at the lowest surface temperature, with no further fundamental limitation reached. Visualization of the shock waves by plasma discharge and reproduction with direct simulation Monte Carlo calculations both indicate that the suppression of the shock structure is partially caused by lowering the momentum flux of reflected particles and significantly enhanced by the adsorption of particles to the surface. We observe that the scaling of beam density with source pressure is recovered, paving the way to order-of-magnitude brighter, cold molecular beams. PMID:28345047

  11. Roald Amundsen: a study in rivalry, masochism and paranoia.

    PubMed

    Anthi, P R

    1999-10-01

    The author suggests that Freud was intrigued by those who explored the still unknown regions of the globe; in 1928 he received a letter from a colleague who knew he was interested in the psychology of polar explorers, asking him to comment on some strange visualizations that had haunted Roald Amundsen, the great polar explorer, when during one of his Arctic expeditions he was attacked and nearly mauled to death by a polar bear. Freud emphasised the quality of resignation and surrender inherent in these peculiar imaginings, but he added that a deeper analysis would require Amundsen's associations. On the basis of relevant biographical data the author tries to make a further investigation of his strange visualizations. These are linked to an underlying masochistic phantasy in which conflicts involving rivalry, autonomy and separation-individuation problems are expressed. He attained the South Pole before Scott and his party, who perished. His triumph and survival on the polar ice evoked an unbearable sense of guilt. Being unable to gain insight into his conflicts, he regressed to a paranoid state. The relation between masochism, the desire to beat and be beaten and rivalry is discussed.

  12. Induced Pluripotent Stem Cells: Emerging Techniques for Nuclear Reprogramming

    PubMed Central

    Han, Ji Woong

    2011-01-01

    Abstract Introduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, can successfully reprogram somatic cells into embryonic stem (ES)-like cells. These cells, which are referred to as induced pluripotent stem (iPS) cells, closely resemble embryonic stem cells in genomic, cell biologic, and phenotypic characteristics, and the creation of these special cells was a major triumph in cell biology. In contrast to pluripotent stem cells generated by somatic cell nuclear-transfer (SCNT) or ES cells derived from the inner cell mass (ICM) of the blastocyst, direct reprogramming provides a convenient and reliable means of generating pluripotent stem cells. iPS cells have already shown incredible potential for research and for therapeutic applications in regenerative medicine within just a few years of their discovery. In this review, current techniques of generating iPS cells and mechanisms of nuclear reprogramming are reviewed, and the potential for therapeutic applications is discussed. Antioxid. Redox Signal. 15, 1799–1820. PMID:21194386

  13. Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration

    PubMed Central

    Chakrabarti, Mrinmay; Haque, Azizul; Banik, Naren L.; Nagarkatti, Prakash; Nagarkatti, Mitzi; Ray, Swapan K.

    2014-01-01

    Recent results from laboratory investigations and clinical trials indicate important roles for estrogen receptor (ER) agonists in protecting the central nervous system (CNS) from noxious consequences of neuroinflammation and neurodegeneration. Neurodegenerative processes in several CNS disorders including spinal cord injury (SCI), multiple sclerosis (MS), Parkinson's disease (PD), and Alzheimer's disease (AD) are associated with activation of microglia and astrocytes, which drive the resident neuroinflammatory response. During neurodegenerative processes, activated microglia and astrocytes cause deleterious effects on surrounding neurons. The inhibitory activity of ER agonists on microglia activation might be a beneficial therapeutic option for delaying the onset or progression of neurodegenerative injuries and diseases. Recent studies suggest that ER agonists can provide neuroprotection by modulation of cell survival mechanisms, synaptic reorganization, regenerative responses to axonal injury, and neurogenesis process. The anti-inflammatory and neuroprotective actions of ER agonists are mediated mainly via two ERs known as ERα and ERβ. Although some studies have suggested that ER agonists may be deleterious to some neuronal populations, the potential clinical benefits of ER agonists for augmenting cognitive function may triumph over the associated side effects. Also, understanding the modulatory activities of ER agonists on inflammatory pathways will possibly lead to the development of selective anti-inflammatory molecules with neuroprotective roles in different CNS disorders such as SCI, MS, PD, and AD in humans. Future studies should be concentrated on finding the most plausible molecular pathways for enhancing protective functions of ER agonists in treating neuroinflammatory and neurodegenerative injuries and diseases in the CNS. PMID:25245209

  14. Lewis Wolpert discusses development and depression. Interview by Joanne Clough.

    PubMed

    Wolpert, Lewis

    2004-06-01

    Lewis Wolpert is Professor of Biology as Applied to Medicine in the Department of Anatomy and Developmental Biology at University College, London, UK. His research interests focus on the mechanisms that are involved in embryonic development. Lewis originally trained as a civil engineer in South Africa but in 1955 made the move to research in cellular biology at King's College, London. He was made a Fellow of the Royal Society in 1980 and awarded the CBE in 1990. Lewis was also made a Fellow of the Royal Society of Literature in 1999 and has presented science on both radio and TV for several years. He was awarded The Royal Society Michael Faraday Prize in 2000 for his contribution to the public understanding of science, most notably through his Chairmanship of the Committee for the Public Understanding of Science (COPUS; 1993-1998). He is the author of numerous books, including Malignant Sadness: The Anatomy of Depression, Principles of Development, The Unnatural Nature of Science and The Triumph of the Embryo. He also writes a regular column for The Independent.

  15. How to communicate with vaccine-hesitant parents.

    PubMed

    Healy, C Mary; Pickering, Larry K

    2011-05-01

    Development of safe and effective vaccines is one the greatest medical triumphs. However, despite high immunization rates in the United States, 85% of health care providers (HCPs) will have a parent refuse a vaccine for his or her child each year. HCPs have the greatest influence on a parent's decision to vaccinate his or her child. To effectively communicate with vaccine-hesitant parents, HCPs must first understand the concerns of parents regarding immunization and understand influences that can lead to misinformation about the safety and effectiveness of vaccines. HCPs should establish an open, nonconfrontational dialogue with vaccine-hesitant parents at an early stage and provide unambiguous, easily comprehensible answers about known vaccine adverse events and provide accurate information about vaccination. Personal stories and visual images of patients and parents affected by vaccine-preventable diseases and reports of disease outbreaks serve as useful reminders of the need to maintain high immunization rates. Ongoing dialogue including provider recommendations may successfully reassure vaccine-hesitant parents that immunization is the best and safest option for their child.

  16. Biofuels 2020: Biorefineries based on lignocellulosic materials.

    PubMed

    Valdivia, Miguel; Galan, Jose Luis; Laffarga, Joaquina; Ramos, Juan-Luis

    2016-09-01

    The production of liquid biofuels to blend with gasoline is of worldwide importance to secure the energy supply while reducing the use of fossil fuels, supporting the development of rural technology with knowledge-based jobs and mitigating greenhouse gas emissions. Today, engineering for plant construction is accessible and new processes using agricultural residues and municipal solid wastes have reached a good degree of maturity and high conversion yields (almost 90% of polysaccharides are converted into monosaccharides ready for fermentation). For the complete success of the 2G technology, it is still necessary to overcome a number of limitations that prevent a first-of-a-kind plant from operating at nominal capacity. We also claim that the triumph of 2G technology requires the development of favourable logistics to guarantee biomass supply and make all actors (farmers, investors, industrial entrepreneurs, government, others) aware that success relies on agreement advances. The growth of ethanol production for 2020 seems to be secured with a number of 2G plants, but public/private investments are still necessary to enable 2G technology to move on ahead from its very early stages to a more mature consolidated technology.

  17. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    SciTech Connect

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-05-12

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. We find our results point at a large Fermi surface consistent with Luttinger's theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition.

  18. The history and impact of the New York City menu labeling law.

    PubMed

    Bernell, Brent

    2010-01-01

    As a result of the recent federal health care legislation, all restaurants in the United States that are part of a chain with twenty or more locations serving substantially the same menu items will be required to post the calorie information of the food they serve directly on menus and menu boards. This development represents the culmination of a regulatory initiative to combat the growth of obesity that only began in 2006 with the decision by the New York City Board of Health to require calorie posting in New York City chain restaurants. That initiative, Regulation 81.50, was the first of its kind in the United States; and yet, less than four years later, the idea has become a national standard. This paper tracks the history of New York City's landmark regulation, detailing the drafting of the law, the initial legal victory for the restaurant association challenging it, and the ultimate triumph of the City in winning legal validation of its calorie posting mandate. In doing so, this paper will also use the New York City regulation as a launching point to discuss the rationale behind menu labeling, to examine the potential legal pitfalls of menu labeling laws, to track the development of the initiative from New York City to a national standard, and finally, to evaluate the preliminary data on whether or not menu labeling is actually effective in achieving its ultimate goal: changing consumer eating habits and reducing obesity.

  19. 'Don't play the butter notes': jazz in medical education.

    PubMed

    Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

    2016-01-01

    Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years.

  20. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-12-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment.

  1. Signaling in T cells – is anything the m(a)TOR with the picture(s)?

    PubMed Central

    Boothby, Mark

    2016-01-01

    The excitement surrounding checkpoint inhibitors in the treatment of patients with cancer exemplifies a triumph of the long-term value of investing in basic science and fundamental questions of T-cell signaling. The pharmaceutical future actively embraces ways of making more patients’ cancers responsive to these inhibitors. Such a process will be aided by elucidation of signaling and regulation. With thousands of articles spread across almost 30 years, this commentary can touch only on portions of the canonical picture of T-cell signaling and provide a few parables from work on mammalian (or mechanistic) target of rapamycin (mTOR) pathways as they link to early and later phases of lymphocyte activation. The piece will turn a critical eye to some issues with models about these pathways in T cells. Many of the best insights lie in the future despite all that is uncovered already, but a contention is that further therapeutic successes will be fostered by dealing with disparities among findings and attention to the temporal, spatial, and stochastic aspects of T-cell responses. Finally, thoughts on some (though not all) items urgently needed for future progress will be mooted. PMID:26949528

  2. Early American Strabismus Surgery: 1840-1845.

    PubMed

    Currie, Benjamin D; Feibel, Robert M

    2015-01-01

    The discovery of effective surgical therapy for strabismus was one of the outstanding triumphs of the first half of 19th-century ophthalmology, just prior to the invention of the ophthalmoscope in 1850. Although priority for the development of strabismus surgery belongs to Johann Friedrich Dieffenbach of Germany, who first reported his surgical results in 1839, 4 cases of tenotomy of the medial rectus muscle had been performed in the United States by William Gibson in 1818 but never published. By 1840, the reports of surgery in Europe had rapidly spread to America where surgeons immediately began using these procedures. The first American surgeon to perform eye muscle surgery and publish his results was John Dix of Boston, and other surgeons were soon reporting their cases as well. We discuss 8 American pioneers in this field during the time (1840-1845) of the first burst of enthusiasm for this surgery. Although these surgeons were active in performing a large number of cases and carefully reporting their experiences and results, they did not make any major advances in the field.

  3. Roe v. Wade. Catholic wisdom.

    PubMed

    Maguire, D

    1998-01-01

    In this commentary, a Roman Catholic professor of moral theory recounts how, during his doctoral work in Rome, he was taught that abortion was intrinsically evil and could never be justified. He was also taught, however, about Probabilism, a Roman Catholic teaching that held that "where there is doubt, there is freedom." In other words, serious doubts based on a person's own insights allow a person moral freedom to choose a course of action in cases of debated moral issues. This moral teaching, a triumph for the rights of personal conscience, which was formulated in the 16th and 17th centuries, has been well-hidden from the laity and neglected by the clergy during the past 100 years. He also learned about Thomas Aquinas who taught that practical moral principals are valid most of the time but can have exceptions depending on circumstances. In addition, early 17th-century church leaders justified abortions performed to save the life of the women. Thus, the Supreme Court's decision in Roe seems to reflect Catholic thinking more accurately than the Vatican's new-found absolutism against abortion.

  4. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed Central

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-01-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment. PMID:12634133

  5. The search for meaning: a pastoral response to suffering.

    PubMed

    Patterson, R A

    1984-06-01

    To help those who suffer, pastoral care ministers must understand what suffering is, its meaning, and the hope that is offered in the Christian message. Suffering involves the entire person--body and spirit. Fear, stress, guilt, and other kinds of emotional distress are as much a part of suffering as physical symptoms. The sufferer sees his or her wholeness being threatened, and seeks explanations for the suffering. The pastoral care minister must help the sufferer to understand that suffering is not divine retribution but a call to discipleship . Because in Jesus' person God has suffered and known powerlessness, pain, and death, he not only understands the sufferer's needs but shares in them with compassion. To help the patient transcend suffering and find its meaning in the context of faith and revelation, the minister must appreciate the patient as a complete, unique, and spiritual being. The minister must be the sufferer's friend, offering respect, tenderness, and love--not merely because the patient is suffering but because as a human being he or she is entitled to such care . Patients who experience such concern from another will be better able to value themselves in moral and ethical terms, experience oneness with the suffering Christ, and triumph over suffering and death.

  6. Transition to space - A history of 'space plane' concepts at Langley Aeronautical Laboratory 1952-1957

    NASA Technical Reports Server (NTRS)

    Hansen, James R.

    1987-01-01

    The supersonic speeds of X-series aircraft and wind tunnel data in the early 1950s demonstrated that hypersonic flight was an achievable goal. A blunt-nosed vehicle was found to form a bow shock that deflected much of the heating an aircraft would otherwise experience at high speeds. It was felt that critical aspects of hypersonic flight, e.g., aerodynamic performance and heating, controllability, etc., could not be fully explored in wind tunnels. The X-15 project was initiated by NASA in 1954 to produce a vehicle capable of Mach 7 flight to altitudes that would permit short evaluations of human performance in microgravity. Design tradeoffs examined in the program are discussed, with emphasis on lifting bodies and winged vehicles with high L/D ratios. Political pressures created by the public triumph of the Sputnik in 1958 removed much of the impetus for development of a manned spaceplane, and long-term goals that eventually led to the Shuttle were delayed by a short-term program oriented toward ballistic manned capsules.

  7. Skin lighteners, Black consumers and Jewish entrepreneurs in South Africa.

    PubMed

    Thomas, Lynn M

    2012-01-01

    This article considers the rise and decline of South Africa's lucrative and controversial skin-lighteners market through examination of the business history of the largest manufacturers, Abraham and Solomon Krok, and their evolving personas as millionaires and philanthropists. Such examination reveals how the country's skin-lighteners trade emerged as part of the broader growth of a black consumer market after the Second World War and how elements of that market became the target of anti-apartheid protests in subsequent decades. It also demonstrates how the Kroks' experiences as second-generation Jewish immigrants shaped their involvement in the trade and how, later, their self-identification as Jewish philanthropists informed their efforts to rehabilitate their reputations following South Africa's 1990 ban on all skin lighteners. Such efforts include the building of Johannesburg's highly acclaimed Apartheid Museum, modelled after the United States Holocaust Memorial Museum. This article explores the profound ironies that some South Africans see in the fact that a museum dedicated to commemorating those who suffered under and, ultimately, triumphed against state racism was financed by a family fortune generated through the sale of skin lighteners to black consumers.

  8. I. Juvara (1913-1996), a surgeon for all seasons.

    PubMed

    Tarcoveanu, E; Dorobat, D; Vasilescu, A; Van Hee, R

    2015-01-01

    Ion Juvara is a creator of a genuine Romanian school of surgery. If I. Juvara had lived and worked in a country that had been the proud owner of a Pantheon, undoubtedly he would have rested there to the end of time, among the eternal ones i.e. those who triumphed against time and who had never been defeated. If the first generation of Romanian surgeons represented mainly by Thoma Ionesco (1860-1926) was educated mainly abroad, the next generation was trained professionally at the Romanian school of surgery. Despite of the hostile period he lived in, I. Juvara kept intact his freedom of thinking and opposed with all his powers abuses of any kind, always preserving his integrity, avoiding with elegance the traps of the totalitarian regime. But even so nobody can state that the professor, who came from -Moldavia, as his master, N. Hortolomei, could not say at the end of his life that he hadn't had a fulfilled professional life, as he is considered even today the greatest surgeon of Romania in the latter half of the 20th century. He was, after all, a surgeon for all seasons.

  9. Systemic treatment for hereditary cancers: a 2012 update.

    PubMed

    Imyanitov, Evgeny N; Byrski, Tomasz

    2013-04-01

    The history of specific therapy for hereditary tumors dates back to mid 1980s and involves a number of reports demonstrating regression of familial colon polyps upon administration of sulindac. Virtually no clinical studies on other hereditary cancer types were available until the year 2009, when Byrski et al. presented the data on unprecedented sensitivity of BRCA1-associated breast malignancies to cisplatin. This breakthrough has revived interest to the treatment of cancer in germ-line mutation carriers. Recent trials and clinical observations have confirmed the efficacy of platinating agents and PARP inhibitors in BRCA1/2-driven breast, ovarian and pancreatic carcinomas. Pegylated liposomal doxorubicin may be considered as a promising treatment option for BRCA1/2-related ovarian cancer after the failure of platinum-containing therapy. Several novel drugs have been recently introduced in the management of rare familial tumor syndromes. Vandetanib, a low-molecular weight RET kinase inhibitor, demonstrated substantial efficacy in the treatment of hereditary and sporadic medullary thyroid cancer. Vismodegib, an inhibitor of SMO oncoprotein, caused regression of basal-cell carcinomas in patients with Gorlin syndrome. Down-regulation of mTOR kinase by everolimus has been successfully used for the therapy of subependymal giant-cell astrocytomas in patients with tuberous sclerosis. The achievements in the prevention, diagnostics and treatment of hereditary cancers may serve as an excellent example of triumph of translational medicine.

  10. German suffering in the Franco–German War, 1870/71.

    PubMed

    Krüger, Christine G

    2011-01-01

    Suffering during the Franco–Prussian War of 1870/71 has to be interpreted in the context of three developments: the willingness to alleviate wartime suffering, which had led to the foundation of the International Red Cross and the Geneva Convention a few years earlier, the industrialization of war, which had enormously increased the efficiency of the weaponry, and the nationalization of war. For many Germans, the outcome of the war justified the wartime suffering, which was often trivialized in the media. The small number of authors who saw the high casualty numbers and the pain of the victims as a warning about the consequences of modern warfare usually belonged to the anti-Prussian opposition. Nationalist euphoria in the face of victory and German unification drowned out such critics, whose patriotism was in doubt. Finally, the remembrance of the war during the Kaiserreich aimed largely at celebrating the triumph of the German army and the foundation of the national state. The glorification of the military was hardly compatible with a detailed description of the misery of the battlefield and the pain of war victims. In 1870/71 and in the subsequent decades, nationalism overwhelmed and eventually excluded a humanitarian narrative.

  11. The Prime Minister and the platypus: A paradox goes to war.

    PubMed

    Lawrence, Natalie

    2012-03-01

    In February 1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain. This request can only be understood if placed in the context of Churchill's passion for exotic pets as well as the rich history of aristocratic menageries and live diplomatic gifts. Obtaining an animal hitherto unseen alive in Europe would have been a great zoological achievement for London Zoo and secured British authority in heated historical taxonomical debates. This zoological triumph, coupled with accomplishing an extravagant enterprise in the middle of war-time austerity would have boosted public morale. Most importantly, despite its death, the platypus, served as a token for mediating the soured relations between Australia and Britain. Churchill's platypus provides a unique case of animal collecting that incorporates effects on international diplomacy and public relations along with a great private eccentricity and passion.

  12. [Analytical chemistry in works of Maria Skłodowska-Curie].

    PubMed

    Hulanicki, Adam

    2012-01-01

    Maria Skłodowska-Curie--a Nobel Prize winner in chemistry--the elements of learning of chemistry gained just by a dint of work of more than ten months in Warsaw in the Institute of Industry and Agriculture Museum. The Nobel Prize concerned a contribution to the progress of chemistry through the discovery of radium and polonium, separation of radium and study of properties of this amazing element. It was awarded for an extremely arduous work, during which the chemical reactions being the principles of analytical chemistry were realized. Unlike to a typical analytical procedure, an initial attempt here was the thousands of kilograms of uranium ore: pitchblende. The final effect was small amounts of new elements: polonium and radium. Both the knowledge and the intuition of the researcher let her have a triumph. The difficulties she experienced because the properties of the searched chemical elements could only be evaluated thanks to the knowledge on other chemical elements. A significant achievement was the determination of the samples by means of radioactivity measurement, which gave rise to radiochemical analytical methods. An extreme analytical precision was demanded in multiple processes of fractional crystallization and precipitation which finally led to the calculation of the atomic mass of radium.

  13. Disability and narrative: new directions for medicine and the medical humanities.

    PubMed

    Garden, Rebecca

    2010-12-01

    People with disabilities are a large minority that disproportionately seeks medical care. However, disability is relatively neglected in medical education and practice, and disabled people experience troubling differences and even disparities in healthcare. Practitioners can help improve healthcare for disabled people through disability studies, a multi-disciplinary field of enquiry that draws on the experiences and perspectives of people with disabilities to address discrimination. This article outlines a disability studies perspective on healthcare, specifically the rejection of the medicalisation of disability and difference in favour of an understanding of disability that focuses on social factors that disable, such as stigmatisation and a lack of accommodation. The 'social model' of disability can be expanded to chronic illness and to the broader work of the medial humanities. The author argues that narrative, particularly first-person accounts, provide a critical resource by representing the point of view of people with disabilities and by offering a means of examining the social context and social determinants of disability. The author examines specific conventions of narrative, the dominant plotlines such as the triumph over adversity, that predetermine experiences of disability and illness. Through disability studies and critical examinations of narrative informed by disability studies, practitioners can provide better care for patients with disabilities and work as allies towards more equitable relations in the clinic.

  14. Resilience to leaking--dynamic systems modeling of information security.

    PubMed

    Hamacher, Kay

    2012-01-01

    Leaking of confidential material is a major threat to information security within organizations and to society as a whole. This insight has gained traction in the political realm since the activities of Wikileaks, which hopes to attack 'unjust' systems or 'conspiracies'. Eventually, such threats to information security rely on a biologistic argument on the benefits and drawbacks that uncontrolled leaking might pose for 'just' and 'unjust' entities. Such biological metaphors are almost exclusively based on the economic advantage of participants. Here, I introduce a mathematical model of the complex dynamics implied by leaking. The complex interactions of adversaries are modeled by coupled logistic equations including network effects of econo-communication networks. The modeling shows, that there might arise situations where the leaking envisioned and encouraged by Wikileaks and the like can strengthen the defending entity (the 'conspiracy'). In particular, the only severe impact leaking can have on an organization seems to originate in the exploitation of leaks by another entity the organization competes with. Therefore, the model suggests that leaks can be used as a `tactical mean' in direct adversary relations, but do not necessarily increase public benefit and societal immunization to 'conspiracies'. Furthermore, within the model the exploitation of the (open) competition between entities seems to be a more promising approach to control malicious organizations : divide-et-impera policies triumph here.

  15. Perceptions of teaching African American students who succeed during science testing: A hermeneutic phenomenological study

    NASA Astrophysics Data System (ADS)

    Harris, Tevis Tramaine

    The purpose of this hermeneutic phenomenological research was to explore the perceptions of teachers as they instruct African American students who are successful on the North Carolina End-of-Grade Science test. The study identified thoughts, feelings, emotions, and challenges that teachers faced when instructing successful African American students from Title I schools in rural community classrooms. The research study analysis utilized NVivo10RTM software and identified common themes in the data. Five themes emerged from interviews with five fifth- and eighth-grade science teachers. Based on the teachers' perceptions, the findings revealed: (a) teachers experience an emotional journey in high poverty schools; (b) investments encompass sacrificing whatever is needed to help students become successful; (c) relationships should be developed between the teacher and student; (d) intentionality is a part of teachers' daily interaction with students; and (e) teachers encounter a challenging opportunity instructing African American students in science. This study provides valuable data in understanding the experiences of teachers as they instruct successful African American students and the challenges, obstacles, and triumphs teachers face when working with this population of students. The implications of the study suggest that educational leaders provide emotional support to help teachers manage the plethora of emotions experienced on a daily basis. Future study of successful teachers of African American students may further inform the dearth of literature surrounding the experience of successful teachers of minority students.

  16. Seven decades of history of science: I. Bernard Cohen (1914-2003), second editor of Isis.

    PubMed

    Dauben, Joseph W; Gleason, Mary Louise; Smith, George E

    2009-03-01

    I. Bernard Cohen (1914-2003), the first American to receive a Ph.D. in history of science, was a Harvard undergraduate ('37) and then a Ph.D. student and protégé of George Sarton, founder of Isis and the History of Science Society. He went on to succeed Sarton as editor of Isis (1952-1958) and, later, president of the Society (1961-1962); he was also a president of the International Union of the History and Philosophy of Science. Cohen was an internationally recognized Newton scholar; his interests were encyclopedic, ranging from science and public policy to the history of computers, with several decades as a special consultant for history of computing with IBM. Among his hundreds of publications were such major books as Franklin and Newton (1956), The Birth of a New Physics (1959; rpt., 1985), The Newtonian Revolution (1980), Revolution in Science (1985), Science and the Founding Fathers (1995), Howard Aiken: Portrait of a Computer Pioneer (1999), and his last book, The Triumph of Numbers (2005), not to mention two jointly authored contributions, the variorum edition and new English translation of Newton's Principia, which will surely still be read a century from now.

  17. Jointly They Edit: Examining the Impact of Community Identification on Political Interaction in Wikipedia

    PubMed Central

    Neff, Jessica J.; Laniado, David; Kappler, Karolin E.; Volkovich, Yana; Aragón, Pablo; Kaltenbrunner, Andreas

    2013-01-01

    Background In their 2005 study, Adamic and Glance coined the memorable phrase ‘divided they blog’, referring to a trend of cyberbalkanization in the political blogosphere, with liberal and conservative blogs tending to link to other blogs with a similar political slant, and not to one another. As political discussion and activity increasingly moves online, the power of framing political discourses is shifting from mass media to social media. Methodology/Principal Findings Continued examination of political interactions online is critical, and we extend this line of research by examining the activities of political users within the Wikipedia community. First, we examined how users in Wikipedia choose to display their political affiliation. Next, we analyzed the patterns of cross-party interaction and community participation among those users proclaiming a political affiliation. In contrast to previous analyses of other social media, we did not find strong trends indicating a preference to interact with members of the same political party within the Wikipedia community. Conclusions/Significance Our results indicate that users who proclaim their political affiliation within the community tend to proclaim their identity as a ‘Wikipedian’ even more loudly. It seems that the shared identity of ‘being Wikipedian’ may be strong enough to triumph over other potentially divisive facets of personal identity, such as political affiliation. PMID:23573269

  18. The New York Stem Cell Foundation. Interview with Susan Solomon.

    PubMed

    Solomon, Susan

    2012-11-01

    We caught up with Susan Solomon, Co-Founder of The New York Stem Cell Foundation, to discuss the role of the Foundation in facilitating some of the top advances in stem cell science in recent years. Susan L Solomon is Chief Executive Officer and Co-Founder of The New York Stem Cell Foundation (NYSCF), a nonprofit organization established in 2005 to accelerate cures through stem cell research. A longtime healthcare advocate, Susan is a founding member and current President of New Yorkers for the Advancement of Medical Research, is on the Executive Committee for the Alliance for Regenerative Medicine, and she has been a member of the Board of Directors of the Juvenile Diabetes Research Foundation, New York Chapter. Susan was also a member of the Strategic Planning Committee of the Empire State Stem Cell Board. In March 2008, Susan received a New York State Women of Excellence Award from the Governor of New York. In September 2008, she received the Triumph Award from the Brooke Ellison Foundation for her work in establishing NYSCF. Prior to founding NYSCF, Susan, an attorney, spent much of her career building businesses. She established and ran Solomon Partners LLC to provide strategic management consulting to corporations, cultural institutions, foundations and nonprofit organizations. She has also held executive positions at MacAndrews and Forbes Holdings and MMG Patricof and Co. She was the founding Chief Executive Officer of Sothebys.com and was President of Sony Worldwide Networks.

  19. A Limited Positioning System for Memory

    PubMed Central

    Shapiro, Matthew

    2015-01-01

    The 2014 Nobel Prize for Physiology or Medicine is an enormous triumph for John O’Keefe and May-Britt and Edvard Moser and an historic event for cognitive and behavioral neuroscience. Neuronal representations decoded from action potentials form a mechanistic bridge between brain and mind and demonstrate the continuity of psychology with biology and physical science. The cognitive map theory powered an ongoing, international research program inspired by Hebb (1949 The Organization of Behavior. New York, NY: Wiley) that showed the way toward linking specific patterns of neuronal activity to high level representation and processing. The prize celebrates a path that led from fundamental, philosophical questions about psychological space to enduring, scientific facts: place, head direction, grid, and boundary fields in the hippocampus, presubiculum, entorhinal cortex, and other brain circuits provide a cellular basis for spatial behavior, learning, and memory. By awarding this prize, the Nobel committee affirmed neuroethology and comparative psychology, marked the end of a chapter in one debate about the existence of animal cognition, and recognized cognitive neurophysiology. The “inner GPS” in the brain” demonstrates “a cellular basis for higher cognitive function.” Animals represent, process, and use information defined by abstract relationships among items (O’Keefe and Conway, 1978) to guide flexible, goal-directed actions. Beyond raising the ontological status of “animal mind,” the committee agreed that abstract mental representations can be investigated rigorously by recording single unit activity in the brain of behaving animals. PMID:25800503

  20. Dogs are man's best friend: in sickness and in health.

    PubMed

    Bentley, R Timothy; Ahmed, Atique U; Yanke, Amy B; Cohen-Gadol, Aaron A; Dey, Mahua

    2016-06-13

    With the median survival of 14.6 months following best available standard of care, malignant gliomas (MGs) remain one of the biggest therapeutic challenges of the modern time. Although the last several decades have witnessed tremendous advancement in our understanding of MG and evolution of many successful preclinical therapeutic strategies, even the most successful preclinical therapeutic strategies often fail to cross the phase I/II clinical trial threshold. One of the significant, but less commonly discussed, barriers in developing effective glioma therapy is the lack of a robust preclinical model. For the last 30 years, rodent orthotopic xenograft models have been extensively used in the preclinical setting. Although they provide a good basic model for understanding tumor biology, their value in successfully translating preclinical therapeutic triumph into clinical success is extremely poor. Companion dogs, which share the same environmental stress as their human counterparts, also spontaneously develop MGs. Dog gliomas that develop spontaneously in an immunocompetent host are very similar to human gliomas and potentially provide a stronger platform for validating the efficacy of therapeutic strategies proven successful in preclinical mouse models. Integrating this model can accelerate development of effective therapeutic options that will benefit both human subjects and pet dogs.

  1. The Chemical Synthesis of Discodermolide

    NASA Astrophysics Data System (ADS)

    Paterson, I.; Florence, G. J.

    The marine sponge-derived polyketide discodermolide is a potent antimitotic agent that represents a promising natural product lead structure in the treatment of cancer. Discodermolide shares the same microtubule-stabilising mechanism of action as Taxol®, inhibits the growth of solid tumours in animal models and shows synergy with Taxol. The pronounced cytotoxicity of discodermolide, which is maintained against cancer cell lines that display resistance to Taxol and other drugs, combined with its scarce availability from its natural source, has fuelled significant academic and industrial interest in devising a practical total synthesis as a means of ensuring a sustainable supply for drug development. This chapter surveys the various total syntheses of discodermolide that have been completed over the period 1993-2007, focusing on the strategies employed for introduction of the multiple stereocentres and achieving control over the alkene geometry, along with the various methods used for realising the pivotal fragment couplings to assemble progressively the full carbon skeleton. This dedicated synthetic effort has triumphed in removing the supply problem for discodermolide, providing sufficient material for extensive biological studies and enabling its early stage clinical development, as well as facilitating SAR studies for lead optimisation.

  2. The sun and exoplanets: The solitude of man

    NASA Astrophysics Data System (ADS)

    Kotov, V. A.

    2012-06-01

    Solar pulsations with a period of P 0 = 9600.606(12) were discovered in 1974. A more recent discovery is that planetary distances in the solar system are subject to spatial resonance with the parameter L 0 ≡ cP 0 ≈ 9600 ls and that the P 0 pulsation itself has cosmological significance (coherent cosmic oscillation, or the pace of absolute time of the universe; c is the speed of light). As of June 2011, 552 extrasolar planets have been discovered. Statistical analysis shows that the distribution of the semimajor axes of alien planets does not have L 0 resonance. Moreover, it appears to have no resonance at all. This frustrates the 20th-century hopes for the existence of extraterrestrial civilizations and possible contact with them. They are simply not there. This explanation of the Fermi paradox, or the Great Silence, appears to rest on the triumph of the anthropic principle, which has been successfully implemented by nature within our planetary system. This leads to a vision whereby the cosmos seems to be created specially for us. The scale L 0 indicates that the sun is a special quantum object, where L 0 is a wave function parameter that is not subject to the rational principles of the classical world, but rather follows a peculiar, quantum logic.

  3. "An expedition to heal the wounds of war". The 1919 eclipse and Eddington as Quaker adventurer.

    PubMed

    Stanley, Matthew

    2003-03-01

    The 1919 eclipse expedition's confirmation of general relativity is often celebrated as a triumph of scientific internationalism. However, British scientific opinion during World War I leaned toward the permanent severance of intellectual ties with Germany. That the expedition came to be remembered as a progressive moment of internationalism was largely the result of the efforts of A. S. Eddington. A devout Quaker, Eddington imported into the scientific community the strategies being used by his coreligionists in the national dialogue: humanize the enemy through personal contact and dramatic projects that highlight the value of peace and cooperation. The essay also addresses the common misconception that Eddington's sympathy for Einstein led him intentionally to misinterpret the expedition's results. The evidence gives no reason to think that Eddington or his coworkers were anything but rigorous. Eddington's pacifism is reflected not in manipulated data but in the meaning of the expedition and the way it entered the collective memory as a celebration of international cooperation in the wake of war.

  4. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

    PubMed Central

    Cantas, L.; Shah, Syed Q. A.; Cavaco, L. M.; Manaia, C. M.; Walsh, F.; Popowska, M.; Garelick, H.; Bürgmann, H.; Sørum, H.

    2013-01-01

    The discovery and introduction of antimicrobial agents to clinical medicine was one of the greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial infections. However, the gradual emergence of populations of antimicrobial-resistant pathogenic bacteria resulting from use, misuse, and abuse of antimicrobials has today become a major global health concern. Antimicrobial resistance (AMR) genes have been suggested to originate from environmental bacteria, as clinically relevant resistance genes have been detected on the chromosome of environmental bacteria. As only a few new antimicrobials have been developed in the last decade, the further evolution of resistance poses a serious threat to public health. Urgent measures are required not only to minimize the use of antimicrobials for prophylactic and therapeutic purposes but also to look for alternative strategies for the control of bacterial infections. This review examines the global picture of antimicrobial resistance, factors that favor its spread, strategies, and limitations for its control and the need for continuous training of all stake-holders i.e., medical, veterinary, public health, and other relevant professionals as well as human consumers, in the appropriate use of antimicrobial drugs. PMID:23675371

  5. Exploding cities: housing the masses in Paris, Chicago, and Mexico City, 1850-2000.

    PubMed

    Platt, Harold L

    2010-01-01

    In The Mystery of Capitalism , the darling of neoliberalism, Hernando de Soto posits that secure property titles explain “why capitalism triumphs in the West and fails everywhere else.” While social scientists have taken him to task for an oversimplification of the causes and remedies of poverty, historians have contributed little to this important policy debate. Applying comparative methods across time and space, such a retrospective analysis exposes serious flaws in de Soto’s thesis. Case studies of Paris, Chicago, and Mexico City covering successive, fifty-year periods support his contention that property law was the single most important factor in determining the fate of rural migrants trying to find a place to live in these exploding cities. But in each case, residential property played a far more complex role in creating the social and physical geography of the city than its simple exchange value. This article illuminates some of these alternative economic uses and embedded cultural meanings of identities of place. It also shows how urban growth machines create capital value in property for some by creating environmental injustice of substandard conditions of everyday life for others.

  6. Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial.

    PubMed

    2013-06-01

    The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study.

  7. Reflections One Year into the 22 Center NIH-funded WRIST Study. A Primer on Conducting a Multicenter Clinical Trial

    PubMed Central

    2013-01-01

    The Wrist and Radius Surgery Trial (WRIST) study group is a collaboration of 22 hand surgery centers in the US, Canada, and Singapore to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al. and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject, yet high level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This paper will trace the course of WRIST by sharing the triumphs, and more importantly the struggles, faced in the first year of this study. PMID:23608306

  8. The Road to Stockholm - Nobel Prizes, Science, and Scientists

    NASA Astrophysics Data System (ADS)

    Hargittai, István

    2002-05-01

    The Nobel Prize is by far the highest recognition a scientist may receive and the only one with which the general public is familiar. Its prestige has reached improbable heights. At the same time a lot of myth surrounds the Nobel Prize, and this is compounded by the fact that people tend to view scientists with some bewilderment.This book introduces the process of selection of the laureates, discusses the ingredients for scientific discovery and for getting recognition. It reviews the decisive moments of scientific careers en route to the Nobel Prize, points to characteristic features of the laureates, the importance of mentors and venues in scientific careers and other components of success. It also covers some discoverers and discoveries for whom and for which the Nobel Prize never materialized.Whereas there is no general recipe for receiving the Nobel Prize, there are common features of successful scientific careers. The book reveals some information about the scientists' lives and careers that may guide other scientists in increasing their chances of becoming more effective and better recognized players--although it is not expected to help anyone to receive the Nobel Prize!For the general reader The Road to Stockholm reveals the human face of scientists and the human side of their endeavours. The Nobel Prize has served as inspiration for scientists and the general public for a hundred years: this book discusses its problems and celebrates its triumphs.

  9. Engineering Manhattan style: Sandia Laboratories as an example of postwar engineering

    SciTech Connect

    1996-09-01

    A great deal has been written about the history of science in America since World War II. Much of that work has explored the government`s research and development establishment, focusing on the scientific community immediately after the war. It is generally argued that the apparent triumphs of the huge and expensive wartime research and development projects gave rise to a belief that scientific resources should be nurtured and kept on hand - ready to provide service in an emergency. The Cold War drive for more and better weapons further fed this belief, leading to a massive system of national laboratories, military laboratories, and defense industries. The science of this complex is built on extensive financial support, the central strategy of which is that by steadily, and occasionally even lavishly funding large research programs, you will have a constant stream of scientific ideas that can be applied to national security purposes. What is true of science, is also true, in slightly modified form, of postwar engineering. The story I want to tell you today is, I think, an example of the way Cold War engineering r&d for national security worked. This report describes aspects of the Sandia National Laboratories.

  10. Rolling back third-party intrusions in the practice of medicine.

    PubMed

    Battistella, R M; Burchfield, D C

    2000-01-01

    Formerly vaunted projections about the triumph of managed care over the provider-controlled health services industry now appear overly optimistic as consumer and provider opposition stiffens. Popular dislike of managed care and purchaser disenchantment over its failure to deliver on promises to control health insurance spending have created a strategic opening for rolling back third-party interference in medical practice. Employer frustration over rising premiums, compounded by workers' antagonism toward benefits restrictions and worry over the loss of government protection against managed care litigation, signals a radical overhaul in the way health insurance is offered. For many employers, substituting defined contribution for defined benefit plans and transferring ownership rights and responsibilities to employees is an attractive solution. Along with the growth of consumer-friendly health plans and a relaxation of onerous managed care practices, physicians can look forward to a restored doctor-patient relationship. This article identifies the forces pushing health care purchasers to adopt defined contribution plans and discusses the implications of such a movement on the physician-patient relationship.

  11. A woman's attempt at a perverse solution and its failure.

    PubMed

    Chasseguet-Smirgel, J

    1988-01-01

    The Programme Committee of the Montreal Congress asked the author to present a case of perversion connected with traumas. Rather than speak about erotization of the effects of the trauma (death or castration anxiety transformed into a source of pleasure) the author relates the first 18 months of analysis of a young woman whose important narcissistic trauma, the result of an inadequate early relationship with her mother, is camouflaged by an avidity for sexual excitations. The aim is to transform narcissistic pain which cannot be worked through into sexuality for which release is possible. Sexuality becomes a means of expressing feelings of hate, revenge and triumph over the primary object. The ensuing perverse solution--an attempt to slip into the primal scene by identification with the sadistic penis--does not succeed. The author advances certain hypotheses concerning the mother-daughter relationship which seem to explain this failure and to explain too the absence of a stable perverse organization in women. There follows a longing to return to the womb, in the shape of the fantasied destruction of the contents of the mother's belly, expressed as the fantasy of the end of the world, and which the author labels as 'the archaic matrix of the Oedipus complex'.

  12. Towards competitive instead of biased testing of heuristics: a reply to hilbig and richter (2011).

    PubMed

    Brighton, Henry; Gigerenzer, Gerd

    2011-01-01

    Our programmatic article on Homo heuristicus (Gigerenzer & Brighton, 2009) included a methodological section specifying three minimum criteria for testing heuristics: competitive tests, individual-level tests, and tests of adaptive selection of heuristics. Using Richter and Späth's (2006) study on the recognition heuristic, we illustrated how violations of these criteria can lead to unsupported conclusions. In their comment, Hilbig and Richter conduct a reanalysis, but again without competitive testing. They neither test nor specify the compensatory model of inference they argue for. Instead, they test whether participants use the recognition heuristic in an unrealistic 100% (or 96%) of cases, report that only some people exhibit this level of consistency, and conclude that most people would follow a compensatory strategy. We know of no model of judgment that predicts 96% correctly. The curious methodological practice of adopting an unrealistic measure of success to argue against a competing model, and to interpret such a finding as a triumph for a preferred but unspecified model, can only hinder progress. Marewski, Gaissmaier, Schooler, Goldstein, and Gigerenzer (2010), in contrast, specified five compensatory models, compared them with the recognition heuristic, and found that the recognition heuristic predicted inferences most accurately.

  13. Organizing for empowerment: an interview with AES's Roger Sant and Dennis Bakke. Interview by Suzy Wetlaufer.

    PubMed

    Sant, R; Bakke, D

    1999-01-01

    The topic of empowerment is receiving a lot of attention, but how many employees are truly empowered? At the global electricity giant AES Corporation, the answer is all 40,000 of them. In this interview, chairman Roger Sant and CEO Dennis Bakke reflect on their trials and triumphs in creating an exceptional company and explain how their employee-run company works. When they founded AES in 1981, Sant and Bakke set out to create a company where people could have engaging experiences on a daily basis--a company that embodied the principles of fairness, integrity, social responsibility, and fun. Putting those principles into action has created something unique--an ecosystem of real empowerment. What does that system look like? Rather than having a traditional hierarchical chain of command, AES is organized around small teams that are responsible for operations and maintenance. Moreover, AES has eliminated functional departments; there's no corporate marketing division or human resources department. For the system to work, every person must become a well-rounded generalist--a mini-CEO. That, in turn, redefines the jobs of the people at headquarters. Instead of setting strategy and making the "the big decisions," Sant and Bakke act as advisers, guardians of the principles, accountability officers, and chief encouragers. Can other companies successfully adopt the mechanics of such a system? Not unless they first adopt the shared principles that have guided AES since its inception. "Empowerment without values isn't empowerment," says Sant. "It's just technique," adds Bakke.

  14. Animal models for HIV/AIDS research

    PubMed Central

    Hatziioannou, Theodora; Evans, David T.

    2015-01-01

    The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection. PMID:23154262

  15. For the love of love: neoliberal governmentality, neoliberal melancholy, critical intersectionality, and the advent of solidarity with the other Mormons.

    PubMed

    Lee, Wenshu

    2012-01-01

    This article performs critical intellectual labor for social and political change against neoliberalism in three ways. First, it explores and connects neoliberal governmentality and neoliberal melancholy, two anchor experiences in our twenty-first century political quotidian. Second, it engages in the sense making of Proposition 8 (a California voter initiative to ban same-sex marriage, which was narrowly passed in 2008) as a case study of religious organizations (the Mormon Church and their religious allies) and their complicity with neoliberal states to foster subjection and subjectivation through critical intersectionality that goes beyond the identity trinity of race, class, and gender. Finally, the article suggests two technologies as a new hand to outplay the excess of neoliberalism for the triumph of our common humanity: 1) mourning over the devastation brought about by neoliberalism and 2) loving our love for those with whom we usually do not form affinity connections, such as the other Mormons, those who are othered because of their departure from church orthodoxy.

  16. Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS).

    PubMed

    Simirgiotis, Mario J; Quispe, Cristina; Bórquez, Jorge; Areche, Carlos; Sepúlveda, Beatriz

    2016-01-15

    A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data (UHPLC-PDA-HESI-orbitrap-MS/MS). In addition, the antioxidant features of the fruits were compared with the varieties Packhman's Triumph and Abate Fetel and correlated with the presence of phenolic compounds. The non-pigmented phenolics were fingerprinted and related to the antioxidant capacities measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and total content of phenolics and flavonoids measured by spectroscopic methods. The machine allowed a fast separation of 15 min employing a flow rate of 1 mL per minute and could accurately identify 25 compounds, including several isorhamnetin derivatives and phenolic acids, present in the peel and pulps of this Chilean variety for the first time. The compounds were monitored using a wavelength range of 210-800 nm. The native small Chilean pear showed the highest antioxidant activity measured as the bleaching of the DPPH radical, the ferric reducing antioxidant power and superoxide anion scavenging activity (8.61 ± 0.65 μg/mL, 712.63 ± 12.12 micromols trolox equivalents (μmol/TE)/100 g FW, and 82.89% ± 2.52% at 100 μg/mL, respectively).

  17. General Relativity and Gravitation

    NASA Astrophysics Data System (ADS)

    Ashtekar, Abhay; Berger, Beverly; Isenberg, James; MacCallum, Malcolm

    2015-07-01

    Part I. Einstein's Triumph: 1. 100 years of general relativity George F. R. Ellis; 2. Was Einstein right? Clifford M. Will; 3. Cosmology David Wands, Misao Sasaki, Eiichiro Komatsu, Roy Maartens and Malcolm A. H. MacCallum; 4. Relativistic astrophysics Peter Schneider, Ramesh Narayan, Jeffrey E. McClintock, Peter Mészáros and Martin J. Rees; Part II. New Window on the Universe: 5. Receiving gravitational waves Beverly K. Berger, Karsten Danzmann, Gabriela Gonzalez, Andrea Lommen, Guido Mueller, Albrecht Rüdiger and William Joseph Weber; 6. Sources of gravitational waves. Theory and observations Alessandra Buonanno and B. S. Sathyaprakash; Part III. Gravity is Geometry, After All: 7. Probing strong field gravity through numerical simulations Frans Pretorius, Matthew W. Choptuik and Luis Lehner; 8. The initial value problem of general relativity and its implications Gregory J. Galloway, Pengzi Miao and Richard Schoen; 9. Global behavior of solutions to Einstein's equations Stefanos Aretakis, James Isenberg, Vincent Moncrief and Igor Rodnianski; Part IV. Beyond Einstein: 10. Quantum fields in curved space-times Stefan Hollands and Robert M. Wald; 11. From general relativity to quantum gravity Abhay Ashtekar, Martin Reuter and Carlo Rovelli; 12. Quantum gravity via unification Henriette Elvang and Gary T. Horowitz.

  18. An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development.

    PubMed

    Chen, Shuai; Luo, Haibin; Chen, Lili; Chen, Jing; Shen, Jianhua; Zhu, Weiliang; Chen, Kaixian; Shen, Xu; Jiang, Hualiang

    2006-01-01

    A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.

  19. Fc-receptors and immunity to malaria: from models to vaccines.

    PubMed

    Pleass, R J

    2009-09-01

    The complexity and number of antigens (Ags) seen during an immune response has hampered the development of malaria vaccines. Antibodies (Abs) play an important role in immunity to malaria and their passive administration is effective at controlling the disease. Abs represent approximately 25% of all proteins undergoing clinical trials, and these 'smart biologicals' have undergone a major revival with the realization that Abs lie at the interface between innate and adaptive immunity. At least 18 Abs have FDA approval for clinical use and approximately 150 are in clinical trials, the majority for the treatment of cancer, allograft rejection or autoimmune disease. Despite these triumphs none are in development for malaria, principally because they are perceived as being too expensive for a disease mainly afflicting poor and marginalized populations. Although unlikely, at least in the foreseeable future, that Ab-based prophylaxis will be made available to the millions of people at risk from malaria, they may be incorporated into current vaccine approaches, since Abs act as correlates of protection in studies aimed at defining the best Ags to include in vaccines. Abs may also form the basis for novel vaccination strategies by targeting Ags to appropriate antigen presenting cells. Therefore, to develop the most efficacious vaccines it will be necessary to fully understand which Abs and Fc-receptors (FcRs) are best engaged for a positive outcome.

  20. Tackling maladaptive memories through reconsolidation: From neural to clinical science.

    PubMed

    Elsey, James W B; Kindt, Merel

    2017-03-18

    Behavioral neuroscience has greatly informed how we understand the formation, persistence, and plasticity of memory. Research has demonstrated that memory reactivation can induce a labile period, during which previously consolidated memories are sensitive to change, and in need of restabilization. This process is known as reconsolidation. Such findings have advanced not only our basic understanding of memory processes, but also hint at the prospect of harnessing these insights for the development of a new generation of treatments for disorders of emotional memory. However, even in simple experimental models, the conditions for inducing memory reconsolidation are complex: memory labilization appears to result from the interplay of learning history, reactivation, and also individual differences, posing difficulties for the translation of basic experimental research into effective clinical interventions. In this paper, we review a selection of influential animal and human research on memory reconsolidation to illustrate key insights these studies afford. We then consider how these findings can inform the development of new treatment approaches, with a particular focus on the transition of memory from reactivation, to reconsolidation, to new memory formation, as well as highlighting possible limitations of experimental models. If the challenges of translational research can be overcome, and if reconsolidation-based procedures become a viable treatment option, then they would be one of the first mental health treatments to be directly derived from basic neuroscience research. This would surely be a triumph for the scientific study of mind and brain.

  1. Cascading effects of defaunation on the coexistence of two specialized insect seed predators.

    PubMed

    Peguero, Guille; Muller-Landau, Helene C; Jansen, Patrick A; Wright, S Joseph

    2017-01-01

    Identification of the mechanisms enabling stable coexistence of species with similar resource requirements is a central challenge in ecology. Such coexistence can be facilitated by species at higher trophic levels through complex multi-trophic interactions, a mechanism that could be compromised by ongoing defaunation. We investigated cascading effects of defaunation on Pachymerus cardo and Speciomerus giganteus, the specialized insect seed predators of the Neotropical palm Attalea butyracea, testing the hypothesis that vertebrate frugivores and granivores facilitate their coexistence. Laboratory experiments showed that the two seed parasitoid species differed strongly in their reproductive ecology. Pachymerus produced many small eggs that it deposited exclusively on the fruit exocarp (exterior). Speciomerus produced few large eggs that it deposited exclusively on the endocarp, which is normally exposed only after a vertebrate handles the fruit. When eggs of the two species were deposited on the same fruit, Pachymerus triumphed only when it had a long head start, and the loser always succumbed to intraguild predation. We collected field data on the fates of 6569 Attalea seeds across sites in central Panama with contrasting degrees of defaunation and wide variation in the abundance of vertebrate frugivores and granivores. Speciomerus dominated where vertebrate communities were intact, whereas Pachymerus dominated in defaunated sites. Variation in the relative abundance of Speciomerus across all 84 sampling sites was strongly positively related to the proportion of seeds attacked by rodents, an indicator of local vertebrate abundance.

  2. Ben Franklin: A Curiosity-Driven Scientist, a Service-Driven Citizen

    NASA Astrophysics Data System (ADS)

    Herschbach, Dudley

    2003-04-01

    At the age of 42, Franklin retired from his prosperous printing business, ``to have leisure to read, study, and make experiments." The scope of his scientific work was remarkable. Beyond his key contributions to understanding electrcity, Franklin wrote major papers on population growth, on meterology, on heat conduction and evaporation, charted the Gulf Stream, studied bioluminescence and the stilling of water waves by a surface layer of oil. He also advanced arguments in favor of conservation of mass and the wave theory of light. Although always alert for practical applications, his style was that of an explorer, eager for adventure and insight. However, Franklin did not consider science as important as public service. He promoted many civic projects in Philadelphia, including a circulating library, fire department, paving of streets, hospital, and was the prime mover in founding the American Philosophical Society and an academy that evolved into the University of Pennsylvania. As well as publishing the most widely read newspaper in the colonies and his bestselling almanac, he became public printer for several of the colonies and postmaster. He lived in England 14 years as a trade representative, largely struggling in vain. At the age of 70, he undertook a decade of service as minister to France, achieving against great odds crucial diplomatic triumphs.

  3. A limited positioning system for memory.

    PubMed

    Shapiro, Matthew

    2015-06-01

    The 2014 Nobel Prize for Physiology or Medicine is an enormous triumph for John O'Keefe and May-Britt and Edvard Moser and an historic event for cognitive and behavioral neuroscience. Neuronal representations decoded from action potentials form a mechanistic bridge between brain and mind and demonstrate the continuity of psychology with biology and physical science. The cognitive map theory powered an ongoing, international research program inspired by Hebb (The Organization of Behavior. New York, NY: Wiley) that showed the way toward linking specific patterns of neuronal activity to high level representation and processing. The prize celebrates a path that led from fundamental, philosophical questions about psychological space to enduring, scientific facts: place, head direction, grid, and boundary fields in the hippocampus, presubiculum, entorhinal cortex, and other brain circuits provide a cellular basis for spatial behavior, learning, and memory. By awarding this prize, the Nobel committee affirmed neuroethology and comparative psychology, marked the end of a chapter in one debate about the existence of animal cognition, and recognized cognitive neurophysiology. The "inner GPS" in the brain" demonstrates "a cellular basis for higher cognitive function." Animals represent, process, and use information defined by abstract relationships among items (O'Keefe and Conway,) to guide flexible, goal-directed actions. Beyond raising the ontological status of "animal mind," the committee agreed that abstract mental representations can be investigated rigorously by recording single unit activity in the brain of behaving animals.

  4. Environmentalism unbound: reconnecting and re-envisioning movements for change.

    PubMed

    Gottlieb, R

    2001-01-01

    Disputes over environmental discourse have generated divergent pathways and discordant messages over the last three decades. An examination of them becomes a study of environmentalism s roots. The workplace is shown as a hidden and often discounted arena of debate about what constitutes an environmental issue. The triumph of the productionist and limitless consumption views helped to establish a focus on environmental change as a form of consumer action. Since the 1970s though, new forms of environmental discourse and action both community- and production-related have sought to shift the terrain. The possibility of becoming a broader, more socially inclusive movement capable of challenging the very structure and logic of capitalist social order is possible again, including the ability to identify new strategies for action. Overcoming the work/environment divide is perhaps the most contentious question facing the future of the environmental and labor movements. New approaches, including developing a community of interests, revaluing work, and developing an ethic of place (with urban, industrial, and global forms), require that the social and the ecological become joined in the construction of a common vision. When any environmental issue can be seen as socially determined, then environmentalism s great task will be to see itself as a primary agent of social change.

  5. Hereditarian scientific fallacies.

    PubMed

    Bailey, R C

    1997-01-01

    Some have recently declared that a hereditarian or more balanced approach has triumphed over environmentalism as an explanatory tool for variation in the cognitive ability and behaviour of humans. However, the entire debate is constrained by several fallacies described here. Heritability of a trait, does not predict the effect of environmental or genetic changes on the trait (Fallacy #1), so knowing heritability does not assist in writing prescriptions for societal ills or budget cuts. Heritability estimates themselves are inaccurate, given the potential for gene-environment covariance and interaction, as well as other non-additive effects on behavior or cognitive ability (Fallacy #2). The 'revolution in molecular genetics' has provided more effective tools for describing the genome, but doesn't permit separation of gene and environmental effects on traits (Fallacy #3). If we were able to measure heritability accurately, it would give us absolutely no indication of whether or not group differences are genetically based (Fallacy #4). Finally, any proposed models of the evolutionary divergence of human groups must more adequately answer the basic questions of such a study, and are not supported by high heritability in present populations (Fallacy #5). Humans are not and should never be exposed to artificial selection and crossing experiments, so behavior geneticists will continue to be very limited in their ability to partition the effects of genes, the environment, and their covariance and interaction on human behavior and cognitive ability.

  6. Modeling and analysis of sub-surface leakage current in nano-MOSFET under cutoff regime

    NASA Astrophysics Data System (ADS)

    Swami, Yashu; Rai, Sanjeev

    2017-02-01

    The high leakage current in nano-meter regimes is becoming a significant portion of power dissipation in nano-MOSFET circuits as threshold voltage, channel length, and gate oxide thickness are scaled down to nano-meter range. Precise leakage current valuation and meticulous modeling of the same at nano-meter technology scale is an increasingly a critical work in designing the low power nano-MOSFET circuits. We present a specific compact model for sub-threshold regime leakage current in bulk driven nano-MOSFETs. The proposed logical model is instigated and executed into the latest updated PTM bulk nano-MOSFET model and is found to be in decent accord with technology-CAD simulation data. This paper also reviews various transistor intrinsic leakage mechanisms for nano-MOSFET exclusively in weak inversion, like drain-induced barricade lowering (DIBL), gate-induced drain leakage (GIDL), gate oxide tunneling (GOT) leakage etc. The root cause of the sub-surface leakage current is mainly due to the nano-scale short channel length causing source-drain coupling even in sub-threshold domain. Consequences leading to carriers triumphing the barricade between the source and drain. The enhanced model effectively considers the following parameter dependence in the account for better-quality value-added results like drain-to-source bias (VDS), gate-to-source bias (VGS), channel length (LG), source/drain junction depth (Xj), bulk doping concentration (NBULK), and operating temperature (Top).

  7. Alternative splicing in chronic myeloid leukemia (CML): a novel therapeutic target?

    PubMed

    Adamia, Sophia; Pilarski, Patrick M; Bar-Natan, Michal; Stone, Richard M; Griffin, James D

    2013-09-01

    Although the imatinib based therapy of chronic myeloid leukemia (CML) represents a triumph of medicine, not all patients with CML benefit from this drug due to the development of resistance and intolerance. The interruption of imatinib treatment is often followed by clinical relapse, suggesting a failure in the killing of residual leukaemic stem cells. There is need to identify alternative selective molecular targets for this disease and develop more effective therapeutic approaches. Alternative pre-mRNA splicing (AS) is an epigenetic process that greatly diversifies the repertoire of the transcriptome. AS orchestrates interactions between various types of proteins and between proteins and nucleic acids. Changes caused by individual splicing events in the cells are small, however, "splicing programs" typically react to these individual changes with considerable effects in cell proliferation, cell survival, and apoptosis. Current evidence suggests a pivotal role of AS in leukemias, particularly in myelodisplastic syndrome (MDS) and chronic lymphocyte leukemia (CLL). From these studies and studies in other malignances, it is clear that splicing abnormalities play a significant role in malignant transformation. Evaluation of AS events in CML can be used to identify novel disease markers and drugsensitive targets to overcome the limits of the small molecule inhibitors currently used for treating patients with CML. The use of aberrant splice variants as disease markers has been reported, however, little is known about the use of splicing abnormalities as drug targets in CML. Herein we discuss potential therapeutic approaches that can be used to target splicing abnormalities in CML.

  8. Cardiac Surgery

    PubMed Central

    Weisse, Allen B.

    2011-01-01

    Well into the first decades of the 20th century, medical opinion held that any surgical attempts to treat heart disease were not only misguided, but unethical. Despite such reservations, innovative surgeons showed that heart wounds could be successfully repaired. Then, extracardiac procedures were performed to correct patent ductus arteriosus, coarctation of the aorta, and tetralogy of Fallot. Direct surgery on the heart was accomplished with closed commissurotomy for mitral stenosis. The introduction of the heart-lung machine and cardiopulmonary bypass enabled the surgical treatment of other congenital and acquired heart diseases. Advances in aortic surgery paralleled these successes. The development of coronary artery bypass grafting greatly aided the treatment of coronary heart disease. Cardiac transplantation, attempts to use the total artificial heart, and the application of ventricular assist devices have brought us to the present day. Although progress in the field of cardiovascular surgery appears to have slowed when compared with the halcyon times of the past, substantial challenges still face cardiac surgeons. It can only be hoped that sufficient resources and incentive can carry the triumphs of the 20th century into the 21st. This review covers past developments and future opportunities in cardiac surgery. PMID:22163121

  9. William T.G. Morton and "The Great Moment".

    PubMed

    Heynick, Frank

    2003-03-01

    The Great Moment, a Paramount movie released in 1944 about dentist William T.G. Morton's discovery of ether anesthesia a century earlier, was the odd-man-out among the movies made by the highly acclaimed director Preston Sturges in that period. It failed to attract large audiences and generally received only lukewarm reviews. Several biographies of Sturges have discussed the reasons for this anomaly; but only recently have drafts of the various versions of Sturges' scripts been published, plus additional background material about the film's production, revisions and editing. Using all this information, the author analyzes the movie and its history and asks what went wrong - and, more importantly, what went right. The general conclusion is that this little-known film has stood the test of time and is worthy of a revival among enthusiasts of dental history and a serious reassessment by movie critics in general. Despite some flaws in the final version, The Great Moment is in fact a remarkable medical biography, incorporating innovative flashback techniques and themes of inspiration and sacrifice mixed with some humor, while remaining reasonably true to historical facts surrounding dentistry's greatest triumph.

  10. CEOS Theory: A Comprehensive Approach to Understanding Hard to Maintain Behaviour Change.

    PubMed

    Borland, Ron

    2017-03-01

    This paper provides a brief introduction to CEOS theory, a comprehensive theory for understanding hard to maintain behaviour change. The name CEOS is an acronym for Context, Executive, and Operational Systems theory. Behaviour is theorised to be the result of the moment by moment interaction between internal needs (operational processes) in relation to environmental conditions, and for humans this is augmented by goal-directed, executive action which can transcend immediate contingencies. All behaviour is generated by operational processes. Goal-directed behaviours only triumph over contingency-generated competing behaviours when operational processes have been sufficiently activated to support them. Affective force can be generated around executive system (ES) goals from such things as memories of direct experience, vicarious experience, and emotionally charged communications mediated through stories the person generates. This paper makes some refinements and elaborations of the theory, particularly around the role of feelings, and of the importance of stories and scripts for facilitating executive action. It also sketches out how it reconceptualises a range of issues relevant to behaviour change. CEOS provides a framework for understanding the limitations of both informational and environmental approaches to behaviour change, the need for self-regulatory strategies and for taking into account more basic aspects of human functioning.

  11. Gravity from the Ground Up

    NASA Astrophysics Data System (ADS)

    Schutz, Bernard

    2003-12-01

    Preface; 1. Gravity on Earth: the inescapable force; 2. And then came Newton: gravity takes center stage; 3. Satellites: what goes up doesn't always come down; 4. The Solar System: a triumph for Newtonian gravity; 5. Tides and tidal forces: the real signature of gravity; 6. Interplanetary travel: the cosmic roller-coaster; 7. Atmospheres: keeping planets covered; 8. Gravity in the Sun: keeping the heat on; 9. Reaching for the stars: the emptiness of outer space; 10. The colors of stars: why they are black (bodies); 11. Stars at work: factories for the Universe; 12. Birth to death: the life cycle of the stars; 13. Binary stars: tidal forces on a huge scale; 14. Galaxies: atoms in the Universe; 15. Physics near the speed of light: Einstein stands on Galileo's shoulders; 16. Relating to Einstein: logic and experiment in relativity; 17. Spacetime geometry: finding out what is not relative; 18. Einstein's gravity: the curvature of spacetime in the Solar System; 19. Einstein's recipe: fashioning the geometry of gravity; 20. Neutron stars: laboratories of strong gravity; 21. Black holes: gravity's one-way street; 22. Gravitational waves: gravity speaks; 23. Gravitational lenses: bringing the Universe into focus; 24. Cosmology: the study of everything; 25. Big Bang: the seed from which we grew; 26. Einstein's Universe: the geometry of cosmology; 27. Ask the Universe: cosmic questions at the frontiers of gravity; Appendix A. Useful constants: values used in this book; Appendix B. Background: what you need to know before you start.

  12. Guinea worm infection in northern Nigeria: Reflections on a disease approaching eradication.

    PubMed

    Greenwood, Brian; Greenwood, Alice; Bradley, Andrew

    2017-02-14

    Global eradication of the Guinea worm (Dracunculus medinensis) is near, although perhaps delayed a little by the discovery of a transmission cycle in dogs. It is, therefore, an appropriate time to reflect on the severe impact of this infection on the life of the communities where it was endemic prior to the start of the global eradication programme in 1981. From 1971-74, we conducted a series of unpublished studies on Guinea worm in a group of villages in Katsina State, northern Nigeria, where the infection was highly endemic. These studies demonstrated the high rate of infection in affected communities, the frequent recurrence of the infection in some subjects and the long-standing disability that remained in some infected individuals. Immunological studies showed a high level of immediate hypersensitivity to adult worm and larval antigens but a down-regulation of TH1 type T cell responses to worm antigens. Freeing communities such as those described in this paper from the scourge of Guinea worm infection for good will be an important public health triumph. This article is protected by copyright. All rights reserved.

  13. Sexual excitement.

    PubMed

    Stoller, R J

    1976-08-01

    Sexual excitement depends on a scenario the person to be aroused has been writing since childhood. The story is an adventure, an autobiography disguised as fiction, in which the hero/heroine hides crucial intrapsychic conflicts, mysteries, screen memories of actual traumatic events and the resolution of these elements into a happy ending, best celebrated by orgasm. The function of the fantasy is to take these painful experiences and convert them to pleasure-triumph. In order to sharpen excitement-the vibration between the fear of original traumas repeating and the hope of a pleasurable conclusion this time-one introduces into the story elements of risk (approximations of the trauma) meant to prevent boredom and safety factors (sub-limnal signals to the storyteller that the risk are not truly dangerous). Sexual fantasy can be studied by means of a person's daydreams (including those chosen in magazines, books, plays, television, movies, and outright pornography), masturbatory behavior, object choice, foreplay, techniques of intercourse, or postcoital behavior.

  14. Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants

    PubMed Central

    Gagliano, Sarah A.; Ravji, Reena; Barnes, Michael R.; Weale, Michael E.; Knight, Jo

    2015-01-01

    Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, statistical learning has been widely investigated for prioritizing genetic variants likely to be associated with complex disease. We compared three published prioritization procedures, which use different statistical learning algorithms and different predictors with regard to the quantity, type and coding. We also explored different combinations of algorithm and annotation set. As an application, we tested which methodology performed best for prioritizing variants using data from a large schizophrenia meta-analysis by the Psychiatric Genomics Consortium. Results suggest that all methods have considerable (and similar) predictive accuracies (AUCs 0.64–0.71) in test set data, but there is more variability in the application to the schizophrenia GWAS. In conclusion, a variety of algorithms and annotations seem to have a similar potential to effectively enrich true risk variants in genome-scale datasets, however none offer more than incremental improvement in prediction. We discuss how methods might be evolved for risk variant prediction to address the impending bottleneck of the new generation of genome re-sequencing studies. PMID:26300220

  15. 16S rRNA gene probe quantitates residual host cell DNA in pharmaceutical-grade plasmid DNA.

    PubMed

    Wang, Kai-Yu; Guo, Ying-Jun; Sun, Shu-Han; Shi, Ke; Zhang, Shu; Wang, Kai-Hui; Yi-Zhang; Chen, Zu-Huan

    2006-03-24

    The development and widespread use of DNA-based vaccination against infectious pathogens have been a great triumph of medical science. Quality control of DNA vaccines as biopharmaceutical productions is a problem to solve. Residual genomic DNA of engineering bacteria has been identified as a potential risk factor, so whose level must be controlled under the regulatory standards. We report a dot-blot hybridization method to detect residual host cell DNA in purified DNA vaccines. The assay utilizes PCR amplified and digoxigenin-labeled Escherichia coli 16S rRNA gene as probe. The sensitivity of the dot-blot hybridization assay with E. coli 16S rRNA gene probe was evaluated in comparison with single copy UidR gene probe. The optimized dot-blot hybridization assay had both low background and a suitable sensitivity, detecting 10 pg of residual E. coli DNA. The method is suitable in the routine use of measuring the levels of residual E. coli DNA in the pharmaceutical-grade DNA vaccine.

  16. Chronic myeloid leukemia: reminiscences and dreams

    PubMed Central

    Mughal, Tariq I.; Radich, Jerald P.; Deininger, Michael W.; Apperley, Jane F.; Hughes, Timothy P.; Harrison, Christine J.; Gambacorti-Passerini, Carlo; Saglio, Giuseppe; Cortes, Jorge; Daley, George Q.

    2016-01-01

    With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people’s lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman. PMID:27132280

  17. Unanswered Questions in the Electroweak Theory

    SciTech Connect

    Quigg, Chris

    2009-11-01

    This article is devoted to the status of the electroweak theory on the eve of experimentation at CERN's Large Hadron Collider. A compact summary of the logic and structure of the electroweak theory precedes an examination of what experimental tests have established so far. The outstanding unconfirmed prediction of the electroweak theory is the existence of the Higgs boson, a weakly interacting spin-zero particle that is the agent of electroweak symmetry breaking, the giver of mass to the weak gauge bosons, the quarks, and the leptons. General arguments imply that the Higgs boson or other new physics is required on the TeV energy scale. Indirect constraints from global analyses of electroweak measurements suggest that the mass of the standard-model Higgs boson is less than 200 GeV. Once its mass is assumed, the properties of the Higgs boson follow from the electroweak theory, and these inform the search for the Higgs boson. Alternative mechanisms for electroweak symmetry breaking are reviewed, and the importance of electroweak symmetry breaking is illuminated by considering a world without a specific mechanism to hide the electroweak symmetry. For all its triumphs, the electroweak theory has many shortcomings.

  18. Stapp's quantum dualism: The James and Heisenberg model of consciousness

    NASA Astrophysics Data System (ADS)

    Noyes, H. P.

    1994-02-01

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James' description of conscious events and for matter from Werner Heisenberg's ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author's opinion fails to establish a monistic, scientific theory. The author traces Stapp's failure to his adamant rejection of arbitrariness, or 'randomness.' This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin's explanation of biology, let alone the triumphs of modern 'neo-Darwinism.' The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp's views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy.

  19. There ain't nothing like a Dame: a commentary on Lonsdale (1947) 'Divergent beam X-ray photography of crystals'.

    PubMed

    Glazer, A M

    2015-04-13

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon-carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

  20. Eggs-ploiting women: a critical feminist analysis of the different principles in transplant and fertility tourism.

    PubMed

    Pfeffer, Naomi

    2011-11-01

    Intergovernmental agencies have recognized that inconsistencies in the way that nation states regulate commerce in human kidneys lubricate transplant tourism, and have repeatedly exhorted recalcitrant governments of both organ-importing and organ-exporting nations to criminalize the exchange of cash for kidneys. Yet these same organizations have elected to remain silent on inconsistencies in the regulation of the trade in human eggs that lubricate fertility tourism. This article is a critical feminist analysis of this paradox. Sketches of the histories of regulation of the global markets in human kidneys and human eggs allow attribution of the different approaches to sales of kidneys and eggs to the triumph of neo-liberalism in the 1990s. Neo-liberalism supports the growth of the medical tourism industry and its niche market catering for infertility, and is responsible for exacerbating the relative disadvantage of poor and powerless women in destination countries, thereby creating the conditions for 'bioavailability', that is, the willingness to exchange body parts for cash. The paper identifies a disturbing correlation between deeply engrained conservative attitudes to women and a plentiful supply of eggs, and concludes by suggesting that what women need to lift themselves out of poverty and discrimination is secure and dignified work.

  1. A history of leprosy in Iran during the 19th and 20th centuries.

    PubMed

    Azizi, Mohammad Hossein; Bahadori, Moslem

    2011-11-01

    From ancient time leprosy has been regarded as a terrifying, stigmatized disease; nevertheless, its cause remained unidentified up to the late 19th century. For centuries numerous leprosy victims worldwide suffered from its morbidity and were socially isolated. The afflicted individuals were segregated because they were considered 'unclean' and had to live in leper colonies, generally under very poor conditions. Physicians believed that leprosy was an incurable, highly contagious, and hereditary disease. In 1873 the Norwegian physician, Gerhard Armauer Hansen (1841-1912), ended the myth of leprosy and discovered its causative agent, known as Mycobacterium leprae. Hansen's discovery was a great triumph in the fight against leprosy. In the 1930's, the first effective antileprosy drug, dapsone, was introduced and in the early 1980's multi-drug therapy was popularized because of high efficacy in resistant cases. Here, we have presented a brief look at the history of leprosy in the world with special focus on the historical account of leprosy in Iran, particularly during the 19th and 20th centuries.

  2. How Voting and Consensus Created the Diagnostic and Statistical Manual of Mental Disorders (DSM-III).

    PubMed

    Davies, James

    2017-04-01

    This paper examines how Task Force votes were central to the development of Diagnostic and Statistical Manual of Mental Disorders (DSM-III and DSM-III-R). Data were obtained through a literature review, investigation of DSM archival material housed at the American Psychiatric Association (APA), and interviews with key Task Force members of DSM-III and DSM-III-R. Such data indicate that Task Force votes played a central role in the making of DSM-III, from establishing diagnostic criteria and diagnostic definitions to settling questions about the inclusion or removal of diagnostic categories. The paper concludes that while the APA represented DSM-III, and the return to descriptive psychiatry it inaugurated, as a triumph of empirically based decision-making, the evidence presented here fails to support that view. Since the DSM is a cumulative project, and as DSM-III lives on through subsequent editions, this paper calls for a more socio-historically informed understanding of DSM's construction to be deployed in how the DSM is taught and implemented in training and clinical settings.

  3. The Conversations About Cancer (CAC) Project – Phase II: National Findings from Viewing When Cancer Calls… and Implications for Entertainment-Education (E-E)

    PubMed Central

    Beach, Wayne A.; Dozier, David M.; Buller, Mary K.; Gutzmer, Kyle; Fluharty, Lyndsay; Myers, Valerie H.; Buller, David B.

    2015-01-01

    Objective We address cancer communication by creating and assessing the impacts of a theatrical production, When Cancer Calls…(WCC…), anchored in conversations from the first natural history of a patient and family members talking through cancer on the telephone. Methods A national study was conducted using a multi-site and randomized controlled trial. An 80-minute video was produced to assess viewing impacts across cancer patients, survivors, and family members. Comparisons were made with a control video on cancer nutrition and diet. Pretest-posttest sample size was 1006, and 669 participants completed a 30-day follow-up impacts assessment. Results All five family and communication indices increased significantly for WCC…. When compared to the placebo, average pretest-posttest change scores were higher for self-efficacy (775%), family fabric (665%), outside support (189%), and family communication (97%). One month following viewings, WCC… participants reported 30% more conversations about cancer among patients and family members about cancer. Conclusion A new genre of Entertainment-Education (E-E) was created that triggers positive reactions from audience members. Managing delicate and often complex communication about the trials, tribulations, hopes, and triumphs of cancer journeys is fundamentally important for everyday living. Practice Implications Unique opportunities exist to make WCC… available to national and global audiences, create tailored curricula, and integrate these viewings into educational programs for patients, family members, and care-provider teams. PMID:26547304

  4. Universal Principles of Depicting Oneself across the Centuries: From Renaissance Self-Portraits to Selfie-Photographs

    PubMed Central

    Carbon, Claus-Christian

    2017-01-01

    Selfie-photography is generally thought of as a cultural mass phenomenon of the early 21st century, inseparably related to the development and triumph of the smartphone with integrated camera. Western culture, however, has been highly familiar with self-depictions since the Renaissance days. Putting the contemporary selfie into this historic context covering more than five centuries of cultural development from Dürer's (1500) famous “Self-Portrait at 28” (also known as “Selbstbildnis im Pelzrock”) to today's Instagram galleries allows for identifying central parallels concerning the technical and social antecedents as well as common underlying psychological factors and shared properties of different kinds of self-depiction. The article provides an overview of the types of contemporary photographic selfies and compares them with painted self-portraits. Finally, this historic perspective leads us to the insight that self-portraits as well as selfies are both referring to nothing less than the “conditio humana.” PMID:28270789

  5. Ignaz Philipp Semmelweis, the prophet of bacteriology.

    PubMed

    Wyklicky, H; Skopec, M

    1983-01-01

    Although by 1931 I. Ph. Semmelweis' achievements and the tragedy of his life had been given their due place in the history of mankind, Alexander Fränkel, formerly Theodor Billroth's assistant and later his biographer, critically stated that the discoverer of the causes of puerperal fever should have defended his discovery with facts rather than with fanaticism. It was only a few years after Semmelweis' death, for instance, that Billroth made laborious experiments. Billroth's work on Coccobacteria had important implications and even influenced Robert Koch, although his hypotheses did not really predict the pathogenic and specific nature of microbes. In 1847 Semmelweis postulated his theory; ie, that the pathological-anatomical changes which he observed in the bodies of the women who died in childbed, in their newborn infants, and in the autopsy findings on his friend Jakob Kolletschka were an entity, morphologically and clinically. He summed them up under the concept of pyemia. Even though Semmelweis was continually abhorred by the evident statistics and would have been able to prove his discovery through animal experiments, he primarily took to the pen to defend his opinion vehemently. Only the clinical facts proved him right during his lifetime; the triumph of bacteriology which began after his death made him not only the "savior of mothers" but also a genial ancestor of bacteriology.

  6. Heme Oxygenase-1: A Metabolic Nike

    PubMed Central

    Nemeth, Zsuzsanna; Correa-Costa, Matheus; Bulmer, Andrew C.; Otterbein, Leo E.

    2014-01-01

    Abstract Significance: Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. Recent Advances: The heme oxygenases (HO) are metabolic enzymes that utilize NADPH and oxygen to break apart the heme moiety liberating biliverdin (BV), carbon monoxide (CO), and iron. Heme that is derived from hemoproteins can be toxic to the cells and if not removed immediately, it causes cell apoptosis and local inflammation. Elimination of heme from the milieu enables generation of three products that influences numerous metabolic changes in the cell. Critical Issues: CO has profound effects on mitochondria and cellular respiration and other hemoproteins to which it can bind and affect their function, while BV and bilirubin (BR), the substrate and product of BV, reductase, respectively, are potent antioxidants. Sequestration of iron into ferritin and its recycling in the tissues is a part of the homeodynamic processes that control oxidation-reduction in cellular metabolism. Further, heme is an important component of a number of metabolic enzymes, and, therefore, HO-1 plays an important role in the modulation of cellular bioenergetics. Future Directions: In this review, we describe the cross-talk between heme oxygenase-1 (HO-1) and its products with other metabolic pathways. HO-1, which we have labeled Nike, the goddess who personified victory, dictates triumph over pathophysiologic conditions, including diabetes, ischemia, and cancer. Antioxid. Redox Signal. 20, 1709–1722. PMID:24180257

  7. Maintenance and loss of heterozygosity in a thelytokous lineage of honey bees (Apis mellifera capensis).

    PubMed

    Goudie, Frances; Allsopp, Michael H; Beekman, Madeleine; Oxley, Peter R; Lim, Julianne; Oldroyd, Benjamin P

    2012-06-01

    An asexual lineage that reproduces by automictic thelytokous parthenogenesis has a problem: rapid loss of heterozygosity resulting in effective inbreeding. Thus, the circumstances under which rare asexual lineages thrive provide insights into the trade-offs that shape the evolution of alternative reproductive strategies across taxa. A socially parasitic lineage of the Cape honey bee, Apis mellifera capensis, provides an example of a thelytokous lineage that has endured for over two decades. It has been proposed that cytological adaptations slow the loss of heterozygosity in this lineage. However, we show that heterozygosity at the complementary sex determining (csd) locus is maintained via selection against homozygous diploid males that arise from recombination. Further, because zygosity is correlated across the genome, it appears that selection against diploid males reduces loss of homozygosity at other loci. Selection against homozygotes at csd results in substantial genetic load, so that if a thelytokous lineage is to endure, unusual ecological circumstances must exist in which asexuality permits such a high degree of fecundity that the genetic load can be tolerated. Without these ecological circumstances, sex will triumph over asexuality. In A. m. capensis, these conditions are provided by the parasitic interaction with its conspecific host, Apis mellifera scutellata.

  8. Superfluid 3He—the Early Days

    NASA Astrophysics Data System (ADS)

    Lee, D. M.; Leggett, A. J.

    2011-08-01

    A history is given of liquid 3He research from the time when 3He first became available following World War II through 1972 when the discovery of the superfluid phases was made. The Fermi liquid nature was established early on, and the Landau Fermi liquid theory provided a framework for understanding the interactions between the Fermions (quasiparticles). The theory's main triumph was to predict zero sound, which was soon discovered experimentally. Experimental techniques are treated, including adiabatic demagnetization, dilution refrigerator technology, and Pomeranchuk cooling. A description of the superfluid 3He discovery experiments using the latter two of these techniques is given. While existing theories provided a basis for understanding the newly discovered superfluid phases in terms of ℓ>0 Cooper pairs, the unexpected stability of the A phase in the high- P, high- T region of the phase diagram needed for its explanation a creative leap beyond the BCS paradigm. The use of sum rules to interpret some of the unusual magnetic resonance in liquid 3He is discussed. Eventually a complete theory of the spin dynamics of superfluid 3He was developed, which predicted many of the exciting phenomena subsequently discovered.

  9. Current options and new developments in the treatment of haemophilia.

    PubMed

    Wong, Trisha; Recht, Michael

    2011-02-12

    Haemophilia A and B are X-linked bleeding disorders due to the inherited deficiency of factor VIII or factor IX, respectively. Of the approximately 1 per 5000-10000 male births affected by haemophilia, 80% are deficient in factor VIII and 20% are deficient in factor IX. Haemophilia is characterized by spontaneous and provoked joint, muscle, gastrointestinal and CNS bleeding leading to major morbidity and even mortality if left untreated or under-treated. The evolution of haemophilia management has been marked by tragedy and triumph over recent decades. Clotting factors and replacement strategies continue to evolve for patients without inhibitors. For patients with an inhibitor, factor replacement for acute bleeding episodes and immune tolerance, immune modulation and extracorporeal methods for inhibitor reduction are the cornerstone of care. In addition, adjuvant therapies such as desmopressin, antifibrinolytics and topical agents also contribute to improved outcomes for patients with and without inhibitors. The future direction of haemophilia care is promising with new longer-acting clotting factors and genetic therapies, including gene transfer and premature termination codon suppressors. With these current and future treatment modalities, the morbidity and mortality rates in patients with haemophilia certainly will continue to improve.

  10. The Evolution of Autonomy.

    PubMed

    Stammers, Trevor

    2015-01-01

    There can be little doubt, at least in the Western world, that autonomy is theruling principle in contemporary bioethics. In spite of its 'triumph' however,the dominance of the utilitarian concept of autonomy is being increasinglyquestioned. In this paper, I explore the nature of autonomy, how it came todisplace the Hippocratic tradition in medicine and how different conceptsof autonomy have evolved. I argue that the reduction of autonomy to'the exercise of personal choice' in medicine has led to a 'tyranny of autonomy' which can be inimical to ethical medical practice rather than conducive to it.I take the case of Kerrie Wooltorton as an illustration of how misplacedadherence to respect for patient autonomy can lead to tragic consequences.An analysis of autonomy based on the work of Rachel Haliburton isdescribed and applied to the role of autonomy in a recent bioethicaldebate--that arising from Savulescu's proposal that conscientious objection by health-care professionals should not be permitted in the NHS. Inconclusion, I suggest Kukla's concept of conscientious autonomy as onepromising pathway to circumvent both the limitations and adverse effectsof the dominance of current (mis)understandings of autonomy in biomedical ethics.

  11. Influence of soil properties and soil leaching on the toxicity of ionic silver to plants.

    PubMed

    Langdon, Kate A; McLaughlin, Mike J; Kirby, Jason K; Merrington, Graham

    2015-11-01

    Silver (Ag) has been shown to exhibit antimicrobial properties; as a result, it is being used increasingly in a wide range of consumer products. With these uses, the likelihood that Ag may enter the environment has increased, predominately via land application of biosolids or irrigation with treated wastewater effluent. The aim of the present study was to investigate the toxicity of Ag to 2 plant species: barley (Hordeum vulgare L. CV Triumph) and tomato (Lycopersicum esculentum) in a range of soils under both leached and unleached conditions. The concentrations that resulted in a 50% reduction of plant growth (EC50) were found to vary up to 20-fold across the soils, indicating a large influence of soil type on Ag toxicity. Overall, barley root elongation was found to be the least sensitive to added Ag, with EC50 values ranging from 51 mg/kg to 1030 mg/kg, whereas the tomato plant height showed higher sensitivity with EC50 values ranging from 46 mg/kg to 486 mg/kg. The effect of leaching was more evident in the barley toxicity results, where higher concentrations of Ag were required to induce toxicity. Variations in soil organic carbon and pH were found to be primarily responsible for mitigating Ag toxicity; therefore, these properties may be used in future risk assessments for Ag to predict toxicity in a wide range of soil types.

  12. The National Library of Medicine. Evolution of a premier information center.

    PubMed

    DeBakey, M E

    1991-09-04

    From a small collection of medical publications in the Surgeon General's Office in 1836, the National Library of Medicine has developed into the leading repository of medical information in the world. Despite strong opposition and impediments from certain quarters, involving considerable machinations and intrigue, the determination of interested medical leaders and sympathetic members of Congress triumphed in having this remarkable institution established on the campus of the National Institutes of Health, Bethesda, Md. As a participant in many of the negotiations preceding that decision, I have happily witnessed the transformation of the Library, long housed in cramped, makeshift quarters, to its present magnificent structures in the heart of our nation's foremost medical research center. Its prodigious collection of print, audiovisual, and electronic information; its imaginative research projects; its excellent outreach program; and its innovative services and products are indispensable to all practicing health professionals, scientists, and medical educators, as well as to journalists, government officials, and others. The ultimate beneficiary, of course, is the patient.

  13. Testing QCD in the non-perturbative regime

    SciTech Connect

    A.W. Thomas

    2007-01-01

    This is an exciting time for strong interaction physics. We have a candidate for a fundamental theory, namely QCD, which has passed all the tests thrown at it in the perturbative regime. In the non-perturbative regime it has also produced some promising results and recently a few triumphs but the next decade will see enormous progress in our ability to unambiguously calculate the consequences of non-perturbative QCD and to test those predictions experimentally. Amongst the new experimental facilities being constructed, the hadronic machines at JPARC and GSI-FAIR and the 12 GeV Upgrade at Jefferson Lab, the major new electromagnetic facility worldwide, present a beautifully complementary network aimed at producing precise new measurements which will advance our knowledge of nuclear systems and push our ability to calculate the consequences of QCD to the limit. We will first outline the plans at Jefferson Lab for doubling the energy of CEBAF. The new facility presents some wonderful opportunities for discovery in strong interaction physics, as well as beyond the standard model. Then we turn to the theoretical developments aimed at extracting precise results for physical hadron properties from lattice QCD simulations. This discussion will begin with classical examples, such as the mass of the nucleon and ?, before dealing with a very recent and spectacular success involving information extracted from modern parity violating electron scattering.

  14. Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants.

    PubMed

    Gagliano, Sarah A; Ravji, Reena; Barnes, Michael R; Weale, Michael E; Knight, Jo

    2015-08-24

    Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, statistical learning has been widely investigated for prioritizing genetic variants likely to be associated with complex disease. We compared three published prioritization procedures, which use different statistical learning algorithms and different predictors with regard to the quantity, type and coding. We also explored different combinations of algorithm and annotation set. As an application, we tested which methodology performed best for prioritizing variants using data from a large schizophrenia meta-analysis by the Psychiatric Genomics Consortium. Results suggest that all methods have considerable (and similar) predictive accuracies (AUCs 0.64-0.71) in test set data, but there is more variability in the application to the schizophrenia GWAS. In conclusion, a variety of algorithms and annotations seem to have a similar potential to effectively enrich true risk variants in genome-scale datasets, however none offer more than incremental improvement in prediction. We discuss how methods might be evolved for risk variant prediction to address the impending bottleneck of the new generation of genome re-sequencing studies.

  15. Resilience to Leaking — Dynamic Systems Modeling of Information Security

    PubMed Central

    Hamacher, Kay

    2012-01-01

    Leaking of confidential material is a major threat to information security within organizations and to society as a whole. This insight has gained traction in the political realm since the activities of Wikileaks, which hopes to attack ‘unjust’ systems or ‘conspiracies’. Eventually, such threats to information security rely on a biologistic argument on the benefits and drawbacks that uncontrolled leaking might pose for ‘just’ and ‘unjust’ entities. Such biological metaphors are almost exclusively based on the economic advantage of participants. Here, I introduce a mathematical model of the complex dynamics implied by leaking. The complex interactions of adversaries are modeled by coupled logistic equations including network effects of econo-communication networks. The modeling shows, that there might arise situations where the leaking envisioned and encouraged by Wikileaks and the like can strengthen the defending entity (the ‘conspiracy’). In particular, the only severe impact leaking can have on an organization seems to originate in the exploitation of leaks by another entity the organization competes with. Therefore, the model suggests that leaks can be used as a `tactical mean’ in direct adversary relations, but do not necessarily increase public benefit and societal immunization to ‘conspiracies’. Furthermore, within the model the exploitation of the (open) competition between entities seems to be a more promising approach to control malicious organizations : divide-et-impera policies triumph here. PMID:23227151

  16. Competition in the UK National Health Service: mission impossible?

    PubMed

    Maynard, A

    1993-03-01

    Despite the dominant ideology of the 1980s being libertarian, pragmatism triumphed and, despite several attempts to privatise the UK National Health Service, the Thatcherite reforms maintained public finance and sought to create competition in the supply of health care. Even this partial reform was radical and has led to major changes in structure and process. However, the Government has refused to evaluate both the cost and the outcome of the reforms. Furthermore, with minimal definition of how the 'internal market' was to work, the Government has regulated the competitive processes in an ad hoc manner, often responding to obvious but unforeseen problems (e.g. local monopoly power). Competition is costly to create, requiring large investments in managerial personnel and information technology, and difficult to sustain because of the propensity of capitalists, through self interest, to destroy capitalism. Problems such as quality, equity and the closure of excess capacity were well defined prior to the NHS reforms and have not yet been resolved following the reforms. Whether adversarial rather than collaborative relationships are more efficient in the health care sector is unknown. Indeed there remains little evidence to sustain the claims of political rhetoric that competition 'works' i.e. increases efficiency, enhances equity and contains costs. Despite this reformers seek to create competition and complete mission impossible.

  17. Austerity: a failed experiment on the people of Europe.

    PubMed

    McKee, Martin; Karanikolos, Marina; Belcher, Paul; Stuckler, David

    2012-08-01

    Many governments in Europe, either of their own volition or at the behest of the international financial institutions, have adopted stringent austerity policies in response to the financial crisis. By contrast, the USA launched a financial stimulus. The results of these experiments are now clear: the American economy is growing and those European countries adopting austerity, including the UK, Ireland, Greece, Portugal and Spain, are stagnating and struggling to repay rising debts. An initial recovery in the UK was halted once austerity measures hit. However, austerity has been not only an economic failure, but also a health failure, with increasing numbers of suicides and, where cuts in health budgets are being imposed, increasing numbers of people being unable to access care. Yet their stories remain largely untold. Here, we argue that there is an alternative to austerity, but that ideology is triumphing over evidence. Our paper was written to contribute to discussions among health policy leaders in Europe that will take place at the 15th European Health Forum at Gastein in October 2012, as its theme 'Crisis and Opportunity - Health in an Age of Austerity'.

  18. In accordance with a "more majestic order". The new math and the nature of mathematics at midcentury.

    PubMed

    Phillips, Christopher J

    2014-09-01

    The "new math" curriculum, one version of which was developed in the 1950s and 1960s by the School Mathematics Study Group under the auspices of the National Science Foundation, occasioned a great deal of controversy among mathematicians. Well before its rejection by parents and teachers, some mathematicians were vocal critics, decrying the new curriculum because of the way it described the practice and history of the discipline. The nature of mathematics, despite the field's triumphs in helping to win World War II and its midcentury promotion as the key to a modern technological society, was surprisingly contested in this period. Supporters of the School Mathematics Study Group, like its director, Edward Begle, emphasized the importance of portraying mathematics as a system of abstract structures, while opponents like Morris Kline argued that math was essentially a tool for understanding the natural world. The debate about the curriculum--and the role of mathematicians in its design--was also a debate about the underlying identity of the subject itself.

  19. A brief history of infection control - past and present.

    PubMed

    Forder, A A

    2007-11-01

    The scientific study of hospital or nosocomial cross-infection began during the first half of the 18th century, and from that time until the start of the 'Bacteriological Era' many of the most notable contributions originated in Scotland. However it was only 100 years later in 1858 that Florence Nightingale promoted the case for hospital reform. The real understanding of hospital infection followed upon the discoveries of Pasteur, Koch and Lister and the beginning of the 'Bacteriological Era'. The close of the 19th century saw the triumphs of hospital reform and asepsis and seemed to herald the final victory over hospital cross-infection. However, the victory was short-lived. It was soon realised that infections occurred not only in obstetric and surgical patients, but in medical patients as well, and that air could also be a source of infection. Streptococcal, staphylococcal and then Gram-negative bacilli as a cause of hospital infection became a focus of attention, as did antibiotic-resistant organisms. This paper looks briefly at the establishment of the control of infection doctor, infection control committee and infection control nurse as well as summarising the changes, problems and advances in infection control up to the present time.

  20. Weddell Sea exploration from ice station

    NASA Astrophysics Data System (ADS)

    Ice Station Weddell Group of Principal Investigators; Chief Scientists; Gordon, Arnold L.

    On January 18, 1915, the Endurance and Sir Ernest Shackleton and his crew were stranded in the ice of the Weddell Sea and began one of the most famous drifts in polar exploration. Shackleton turned a failure into a triumph by leading all of his team to safety [Shackleton, 1919]. The drift track of the Endurance and the ice floe occupied by her stranded crew after the ship was lost on November 21, 1915, at 68°38.5‧S and 52°26.5‧W, carried the group along the western rim of the Weddell Gyre, representing a rare human presence in this region of perennial sea-ice cover.Seventy-seven years later, in 1992, the first intentional scientific Southern Ocean ice drift station, Ice Station Weddell-1 (ISW-1), was established in the western Weddell Sea by a joint effort of the United States and Russia. ISW-1 followed the track of the Endurance closely (Figure 1) and gathered an impressive array of data in this largely unexplored corner of the Southern Ocean, the western edge of the Weddell Gyre.

  1. [On the psychoanalytic view of Harry Potter].

    PubMed

    Subkowski, Peter

    2008-01-01

    This paper analyzes the exemplary mental development that Harry Potter undertakes after the massive traumatic loss of his parents at the early age of 15 months and the following neglect by his relatives until he becomes a mature adult. On the basis of his internalized mothers love and by identification with his father and his paternally friend Dumbledore Harry gains increasing self-confidence and new friends in his peer group in the course of time. After passing numerous conflicts and experiencing friendship Harry reaches the stage of initiation into the world of the adults. On the oedipal level he finally is able to deidealize his father and Dumbledore. And at the end Harry is not seduced by absolute power and the triumph over death itself. On the contrary he is ready to sacrifice himself for his friends and thus can overcome the fragmented Voldemort. Readers can identify with Harry, can recognize their own experiences and conflicts and can deal with the proposed conflict resolution patterns on different levels. This contemporary "Bildungsroman" deals with important typical interpersonal and cultural issues for young people. This is what leads young readers to strong resonance and identification processes and explains the great success of the Harry Potter story.

  2. Improved Regression Analysis of Temperature-Dependent Strain-Gage Balance Calibration Data

    NASA Technical Reports Server (NTRS)

    Ulbrich, N.

    2015-01-01

    An improved approach is discussed that may be used to directly include first and second order temperature effects in the load prediction algorithm of a wind tunnel strain-gage balance. The improved approach was designed for the Iterative Method that fits strain-gage outputs as a function of calibration loads and uses a load iteration scheme during the wind tunnel test to predict loads from measured gage outputs. The improved approach assumes that the strain-gage balance is at a constant uniform temperature when it is calibrated and used. First, the method introduces a new independent variable for the regression analysis of the balance calibration data. The new variable is designed as the difference between the uniform temperature of the balance and a global reference temperature. This reference temperature should be the primary calibration temperature of the balance so that, if needed, a tare load iteration can be performed. Then, two temperature{dependent terms are included in the regression models of the gage outputs. They are the temperature difference itself and the square of the temperature difference. Simulated temperature{dependent data obtained from Triumph Aerospace's 2013 calibration of NASA's ARC-30K five component semi{span balance is used to illustrate the application of the improved approach.

  3. Behavioral and mechanical determinants of collective subsurface nest excavation.

    PubMed

    Monaenkova, Daria; Gravish, Nick; Rodriguez, Greggory; Kutner, Rachel; Goodisman, Michael A D; Goldman, Daniel I

    2015-05-01

    Collective construction of topologically complex structures is one of the triumphs of social behavior. For example, many ant species construct underground nests composed of networks of tunnels and chambers. Excavation by these 'superorganisms' depends on the biomechanics of substrate manipulation, the interaction of individuals, and media stability and cohesiveness. To discover principles of robust social excavation, we used X-ray computed tomography to monitor the growth in three dimensions of nests built by groups of fire ants (Solenopsis invicta) in laboratory substrates composed of silica particles, manipulating two substrate properties: particle size and gravimetric moisture content. Ants were capable of nest construction in all substrates tested other than completely dry or fully saturated; for a given particle size, nest volume was relatively insensitive to moisture content. Tunnels were deepest at intermediate moisture content and the maximum tunnel depth correlated with measured yield force on small rod-shaped intruders (a proxy for cohesive strength). This implies that increased cohesive strength allowed creation of tunnels that were resistant to perturbation but did not decrease individual excavation ability. Ants used two distinct behaviors to create pellets composed of wetted particles, depending on substrate composition. However, despite the ability to create larger stable pellets in more cohesive substrates, pellet sizes were similar across all conditions. We posit that this pellet size balances the individual's load-carrying ability with the need to carry this pellet through confined crowded tunnels. We conclude that effective excavation of similarly shaped nests can occur in a diversity of substrates through sophisticated digging behaviors by individuals which accommodate both differing substrate properties and the need to work within the collective.

  4. Looking for earths : the race to find new solar systems

    NASA Astrophysics Data System (ADS)

    Boss, Alan

    1998-09-01

    The ultimate insider's account of astronomy's fantastic voyage in search of brave new worlds in faraway galaxies "Highly recommended." -Science and Technology "Full of humor, heartbreak, and a deep understanding of the ardor and luck that compose years of research. . . . The reader becomes not merely a receiver of Boss's vision, but a fellow explorer." -Astronomy "A rewarding account." -Scientific American Are we alone in the universe . . . or are there other planets generating and sustaining life? The question may be as old as civilization, but in the twilight of a century marked by countless frustrated quests to find other solar systems, several teams of pioneering astronomers have at last discovered a rich crop of mammoth, Jupiter-sized gas planets -the first compelling evidence that there may indeed be life in other galaxies. In Looking for Earths, a prominent planetary scientist takes us along on this thrilling hunt for new life, revealing the behind-the-scenes stories of scientific determination, frustration, and triumph. Ushering us to the mountaintop observatories that house the world's most powerful telescopes, and into the tension-filled scientific meetings where new results are announced and old results overturned, Alan Boss brings the process of exploration vividly alive. Experience the roller-coaster ride as intricate observations of minuscule stellar wobbles raise hopes that at last a true planet has been found, only to be almost immediately shattered by more powerful observations. Boss also introduces the principal players whose dreams defied all odds and made the first major discovery possible. Like no other book, Looking for Earths captures the lively tension between theory and observation that defines cutting-edge astronomical discovery, along with the heated battles that will determine the direction of big-ticket American astronomy for years to come. "You will find no better introduction to one of the truly revolutionary developments in modern

  5. A Literature Investigation about Electrospinning and Nanofibers: Historical Trends, Current Status and Future Challenges.

    PubMed

    Nascimento, Marcio L F; Araújo, Evando S; Cordeiro, Erlon R; de Oliveira, Ariadne H P; de Oliveira, Helinando P

    2015-01-01

    The development of new fibrilar materials based on electrospinning (ES) technique has a notable history of nearly four centuries of discoveries and results. The eletrospinning manufacturing is one of the most widely reported methods for nanofiber (NF) manufacturing, providing security, high quality and productivity. In spite of the first patent about electrospinning has been applied in April 5(th), 1900 by John Francis Cooley, a historical perspective (since 1600s) about this amazing discovery represents an important step for future applications. Nanofibers have been considered one of the top interesting fundamental study objects for academicians, and greatest intriguing business materials for modern industry. As a consequence, lucrative organizations and companies have explored the relevance of nanofibers. In this paper, the quantity of published manuscripts and patent inventions is presented and the correlation of research activities to the production of new electrospinning materials is shown. China and the United States have been leading in electrospinning and nanofibers development. The company triumph is mostly dependent on applications improvement relevant for broader business society. A dramatic rise of interest in nanofibers produced by electrospinning technique has been confirmed due to the publication data, author's affiliation, keywords, and essential characterization procedures. Is has been shown that the number of publications on electrospinning and nanofibers researches from academic institutions is higher than industrial laboratories. More than 1,891 patents using the term "electrospinning" and 2,960 with the term "nanofibers" according to the European Patent Office at title or abstract have been filed around the world up to 2013. These numbers just continue to increase along with worldwide ES-related sales. Curiously, for the same period 11,973 electrospinning documents and 18,679 nanofibers-related (mainly manuscripts) were published considering

  6. How should doctors approach patients? A Confucian reflection on personhood

    PubMed Central

    Tsai, D. F.

    2001-01-01

    The modern doctor-patient relationship displays a patient-centred, mutual-participation characteristic rather than the former active-passive or guidance-cooperation models in terms of medical decision making. Respecting the wishes of patients, amounting to more than mere concern for their welfare, has become the feature central to certain modern bioethics theories. A group of ethical principles such as respect for autonomy, beneficence, non-maleficence, and justice has been proposed by bioethicists and widely adopted by many medical societies as an ethical guide to how doctors, in their daily practice, should treat their patients. However, seeing patients as persons who are rational, self-conscious beings capable of valuing their own lives, and who are consequently entitled to the liberty and rights to choose for themselves, is in general the backbone of Western bioethical principles. Since Confucian philosophy has long been a representative of the East-Asia cultural tradition and Confucian bioethics has recently been developed as a theory of applied ethics, examining Confucius's idea of "persons" may shed some light on the current bioethical debates. Confucius's concept of persons, which is best interpreted via his theories of "chun-tze", (the morally ideal person) encapsulating a two-dimensional approach, (the "autonomous person" and the "relational person"), provides a more comprehensive model regarding what a person is and how he/she should be treated. This two-dimensional approach sees a person not only as a rational, autonomous agent but also as a relational, altruistic identity whose self actualisation involves incessant participating in and promoting of the welfare of his fellow persons. Hence this may balance the current bioethical trend whereby "respect for autonomy" often triumphs. Key Words: Personhood • autonomy • Confucian ethics • physician-patient relationship • principle-oriented bioethics PMID:11233378

  7. Masters of Healing: Cocaine and the Ideal of the Victorian Medical Man.

    PubMed

    Small, Douglas

    2016-01-02

    This article offers a new perspective on the relationship between cocaine and medical practitioners in late nineteenth- and early twentieth-century Britain. Cocaine is often understood as one of a number of potentially addictive substances to which Victorian physicians and surgeons were regularly exposed, and tempted to indulge in. However, while cocaine has frequently been associated with discourses of addiction, this article proposes that it was also widely represented as a technological triumph, and that the drug was frequently used as a symbol for the scientific and moral virtues of the medical man. The argument draws on popular journalism, medical publications, and fiction to establish the cultural context of cocaine at the fin de siècle. In 1884, cocaine was revealed to be the first effective local anaesthetic, and this article traces the processes by which cocaine came to be regarded as the iconic achievement of nineteenth-century therapeutic science. This aura of innovative brilliance in turn communicated itself to the medical professionals who employed cocaine in their work, so that many patients and practitioners alike depicted cocaine as a most fitting emblem for the idealized selfhood of the modern medical man. This idea also informs portrayals of the drug in fiction, and I conclude with a detailed analysis of L. T. Meade's 1895 short story, 'The Red Bracelet' (published in the Strand Magazine as part of Meade's series, 'Stories from the Diary of a Doctor'), as an example of the way in which cocaine functions as metaphor for the physician's unassailable moral primacy and technical excellence.

  8. How Citation Boosts Promote Scientific Paradigm Shifts and Nobel Prizes

    PubMed Central

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-01-01

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the “boosting effect” of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying “boost factor” is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract. PMID:21573229

  9. In the ear of the beholder: how age shapes emotion processing in nonverbal vocalizations.

    PubMed

    Lima, César F; Alves, Tiago; Scott, Sophie K; Castro, São Luís

    2014-02-01

    It is well established that emotion recognition of facial expressions declines with age, but evidence for age-related differences in vocal emotions is more limited. This is especially true for nonverbal vocalizations such as laughter, sobs, or sighs. In this study, 43 younger adults (M = 22 years) and 43 older ones (M = 61.4 years) provided multiple emotion ratings of nonverbal emotional vocalizations. Contrasting with previous research, which often includes only one positive emotion (happiness) versus several negative ones, we examined 4 positive and 4 negative emotions: achievement/triumph, amusement, pleasure, relief, anger, disgust, fear, and sadness. We controlled for hearing loss and assessed general cognitive decline, cognitive control, verbal intelligence, working memory, current affect, emotion regulation, and personality. Older adults were less sensitive than younger ones to the intended vocal emotions, as indicated by decrements in ratings on the intended emotion scales and accuracy. These effects were similar for positive and negative emotions, and they were independent of age-related differences in cognitive, affective, and personality measures. Regression analyses revealed that younger and older participants' responses could be predicted from the acoustic properties of the temporal, intensity, fundamental frequency, and spectral profile of the vocalizations. The two groups were similarly efficient in using the acoustic cues, but there were differences in the patterns of emotion-specific predictors. This study suggests that ageing produces specific changes on the processing of nonverbal vocalizations. That decrements were not attenuated for positive emotions indicates that they cannot be explained by a positivity effect in older adults.

  10. IPY Storytelling

    NASA Astrophysics Data System (ADS)

    Linder, C. A.; Lippsett, L.; Carlowicz, M.

    2007-12-01

    "Live from the Poles" tells the stories of science on ice. This NSF-sponsored education and outreach project (polardiscovery.whoi.edu) aims to go beyond results and sound bites to convey the full experience of polar research with all its trials, triumphs, and nuances. It uses a multimedia approach, including online photo essays posted daily during expeditions, along with videos, interviews, podcasts, animations, and audio clips-plus live satellite phone calls to audiences in major museums and science centers throughout the country. Our media team, typically a science writer and photographer, are embedded into the research program for the duration of the project. They live in the polar environment with the science party, bolstering their ability to convey the "human side" of the story that engages the public: What inspired the researchers to study the Arctic? What do they eat for dinner? How do they cope with the environment and being away from home? What other unexpected challenges will arise and how will they be overcome? The first expedition, in April 2007, shared the excitement of working in Nunavut, Canada, as researchers prepared to deploy instruments at the North Pole Environmental Observatory. The second followed an international scientific team's search for hydrothermal vents aboard the Swedish icebreaker Oden in July-August 2007. The Polar Discovery Web site has attracted more than 74,000 online visitors in its first eight months of operation. During the first two expeditions, the project facilitated 15 live audio talks to museum audiences, media outlets, and teacher workshops. This presentation will focus on lessons learned from the first two expeditions, with perspectives on science reporting and writing in the field from a science writer at AGU, and on the art of documentary photography, from photographer and project manager Chris Linder, who will speak via satellite phone from the third Polar Discovery expedition in Antarctica.

  11. A brief history of hepatitis milestones.

    PubMed

    Trepo, Christian

    2014-02-01

    Hepatitis has been a major plague of mankind. The history of the discovery of causative viruses is one of the most fascinating scientific adventures of this half century. Individualization of several types of hepatitis only emerged after world war two. Their identification has been associated with milestones which revolutionized medicine and public health. The discovery of HBV brought the first ever vaccine not prepared by tissue culture but initially directly from plasma and soon the first vaccine produced by genetic engineering. HBV vaccine proved to be the first "anti-cancer" vaccine by preventing hepatocellular carcinoma and practically eradicating it from childhood in Taiwan. Successful vaccines became also available for HAV and more recently HEV. The discovery of HCV in 1989 opened a new era since it was the first virus was identified by a direct molecular approach. Two billion people are infected with HBV and 350 million are chronic carriers of the virus. The extraordinary effectiveness of HBV vaccination was best illustrated in Taiwan and Singapore where in less than 2 decades HBs Ag carriers dropped from 9,1% to 2,7% and HCC from 27% to 17%. Successful development of nucleos(t)ides analogs make it now possible to fully control disease progression with a daily pill long term therapy. The progress in HCV therapy has been even more spectacular and successful treatment jumped from 6 % with interferon alone in 1986 to more than 80% in 2013 with triple combination therapies. Remarkably chronic hepatitis C is the only chronic disease which is curable. It will be soon possible to eradicate HCV infection with, an all oral, daily single pill (containing several molecules) for 3 to 6 months which will cure over 90% of patients. This unprecedented therapeutic victory benefiting hundred millions of people matches the triumphs over small pox, polio and tuberculosis. The next 10 years should undoubtedly witness cure or full control over all forms of acute and chronic

  12. Lean consumption.

    PubMed

    Womack, James P; Jones, Daniel T

    2005-03-01

    During the past 20 years, the real price of most consumer goods has fallen worldwide, the variety of goods and the range of sales channels offering them have continued to grow, and product quality has steadily improved. So why is consumption often so frustrating? It doesn't have to be--and shouldn't be--the authors say. They argue that it's time to apply lean thinking to the processes of consumption--to give consumers the full value they want from goods and services with the greatest efficiency and the least pain. Companies may think they save time and money by off-loading work to the consumer but, in fact, the opposite is true. By streamlining their systems for providing goods and services, and by making it easier for customers to buy and use those products and services, a growing number of companies are actually lowering costs while saving everyone time. In the process, these businesses are learning more about their customers, strengthening consumer loyalty, and attracting new customers who are defecting from less user-friendly competitors. The challenge lies with the retailers, service providers, manufacturers, and suppliers that are not used to looking at total cost from the standpoint of the consumer and even less accustomed to working with customers to optimize the consumption process. Lean consumption requires a fundamental shift in the way companies think about the relationship between provision and consumption, and the role their customers play in these processes. It also requires consumers to change the nature of their relationships with the companies they patronize. Lean production has clearly triumphed over similar obstacles in recent years to become the dominant global manufacturing model. Lean consumption, its logical companion, can't be far behind.

  13. The new world disorder.

    PubMed

    Checa, Nicolas; Maguire, John; Barney, Jonathan

    2003-08-01

    On January 1, 1995, representatives from 76 countries signed the World Trade Organization charter, which for years had been part of a temporary trade agreement. The WTO's emergence as a fully empowered supranational body seemed to reflect the triumph of what the first President Bush had described as the "new world order." That order was based on two assumptions: that a healthy economy and a sound financial system make for political stability, and that countries in business together do not fight each other. The number one priority of U.S. foreign policy was thus to encourage the former Communist countries of Europe and the developing nations in Latin America, Asia, and Africa to adopt business-friendly policies. Private capital would flow from the developed world into these countries, creating economic growth. It sounded too good to be true, and so it proved. The new world order of Bush père and his successor, Bill Clinton, has been replaced by the new world disorder of Bush fils. Under the second Bush's administration, the economic and political rationale-behind the Washington consensus of the 1990s has unraveled, forcing a radical change in our perceptions of which countries are safe for business. Negotiating this new environment will require companies to more rigorously evaluate political events and more carefully assess the links between political, economic, and financial risk factors. They'll need to be more selective about which markets to enter, and they'll need to think differently about how to position themselves in those markets. The geopolitical events of the past year, the Bush administration's global war on terror, as well as ongoing convulsions in traditional political and economic relationships must be understood and managed by corporate leaders worldwide. With careful analysis, business leaders can increase their companies' visibility and better respond to the uncertainties of the new world disorder.

  14. An Earlier Natural Mechanism Proposal for the Closure of the Ozone Hole and the Present 30% Closure

    NASA Astrophysics Data System (ADS)

    Yousef, Shahinaz M.; Al-Kuhaimi, Siham A.; Bebars, Aisha

    2011-06-01

    A prolonged period of reduced solar activity of the order of few decades is expected owing to the presence of weak solar cycles series like those around 1800 and 1900 AD. Reduced UV flux is forecasted. The multitude of phytoplanktons in the Antarctic Ocean which are harmed by excessive UV passing through the ozone hole are expected to recover owing to the reduced solar UV doze even with the existence of ozone hole. An increase of only 10% of the phytoplankton would remove about 5 Gigatons of carbon dioxide from the atmosphere annually (which is equal to the amount of carbon dioxide emitted currently by fossil fuel utilization) and sink it into the ocean. Reduction of carbon dioxide from the atmosphere will lead to cooling of the troposphere and hence warming of Antarctic stratospheric clouds which are the sight of ozone destruction. Eventually, this procedure will hopefully lead to Antarctic ozone hole closure. The paper also discuss the implication of the 1997 solar induced climate change on the appearance of the Arctic ozone hole and the reduction of the Antarctic ozone hole. Anther more serious solar indsolarinduced climate change is currently on due to the end of the first weak solar cycle number 23 and the start of predicated second weaker solar cycle number 24. A climate change, which has already brought global cooling to the earth. The Ozone hole has been closed by 30% in 2007 as prdicted which a triumph is for the subject of sun-Earth connections. It is also predicted that further closures in the coming few years will occur due to solar induced climate changes. The forecast of the ozone hole closure was predicted in earlier papers.

  15. MicroPET/CT Imaging of an Orthotopic Model of Human Glioblastoma Multiforme and Evaluation of Pulsed Low-Dose Irradiation

    SciTech Connect

    Park, Sean S.; Chunta, John L.; Robertson, John M.; Martinez, Alvaro A.; Oliver Wong, Ching-Yee; Amin, Mitual; Wilson, George D.; Marples, Brian

    2011-07-01

    Purpose: Glioblastoma multiforme (GBM) is an aggressive tumor that typically causes death due to local progression. To assess a novel low-dose radiotherapy regimen for treating GBM, we developed an orthotopic murine model of human GBM and evaluated in vivo treatment efficacy using micro-positron-emission tomography/computed tomography (microPET/CT) tumor imaging. Methods: Orthotopic GBM xenografts were established in nude mice and treated with standard 2-Gy fractionation or 10 0.2-Gy pulses with 3-min interpulse intervals, for 7 consecutive days, for a total dose of 14 Gy. Tumor growth was quantified weekly using the Flex Triumph (GE Healthcare/Gamma Medica-Ideas, Waukesha, WI) combined PET-single-photon emission CT (SPECT)-CT imaging system and necropsy histopathology. Normal tissue damage was assessed by counting dead neural cells in tissue sections from irradiated fields. Results: Tumor engraftment efficiency for U87MG cells was 86%. Implanting 0.5 x 10{sup 6} cells produced a 50- to 70-mm{sup 3} tumor in 10 to 14 days. A significant correlation was seen between CT-derived tumor volume and histopathology-measured volume (p = 0.018). The low-dose 0.2-Gy pulsed regimen produced a significantly longer tumor growth delay than standard 2-Gy fractionation (p = 0.045). Less normal neuronal cell death was observed after the pulsed delivery method (p = 0.004). Conclusion: This study successfully demonstrated the feasibility of in vivo brain tumor imaging and longitudinal assessment of tumor growth and treatment response with microPET/CT. Pulsed radiation treatment was more efficacious than the standard fractionated treatment and was associated with less normal tissue damage.

  16. Aroma-Active Compounds in Bartlett Pears and Their Changes during the Manufacturing Process of Bartlett Pear Brandy.

    PubMed

    Zierer, Bianca; Schieberle, Peter; Granvogl, Michael

    2016-12-21

    Application of aroma extract dilution analysis to Bartlett pears and the fermented mash produced thereof revealed 24 and 34 aroma-active compounds in the flavor dilution (FD) factor range between 8 and 8192. Twenty-eight compounds, which have not been described before in Bartlett pears or in fermented pear mash, were identified. While ethyl (E,Z)-2,4-decadienoate (pear-like, metallic odor impression), hexyl acetate (green, fruity), and acetic acid (vinegar-like) showed the highest concentrations in Bartlett pears, ethanol (ethanolic), acetic acid, 3-methyl-1-butanol (malty), 1-hexanol (grassy, marzipan-like), (S)-2- and 3-methylbutanoic acid (sweaty), and 2-phenylethanol (flowery, honey-like) were present at the highest amounts in the fermented mash. The key aroma compounds were quantitated in each pear brandy production step (pears, fermented mash, distillate, and aged distillate) by stable isotope dilution analysis showing a clear influence of each step on the overall aroma of the spirit and, consequently, revealing clearly changing concentrations (e.g., of ethyl (S)-2-methylbutanoate, (E)-β-damascenone, ethyl (E,Z)-2,4-decadienoate, and ethyl (E,E)-2,4-decadienoate) and different aroma perceptions during the manufacturing process. In addition, the concentrations of the so-called "pear esters" ethyl (E,Z)-2,4-decadienoate and ethyl (E,E)-2,4-decadienoate were determined in 6 different pear varieties (Abate Fetel, Anjou, Bartlett, Forelle, Kaiser Alexander, and Packham's Triumph) clearly demonstrating the aroma potential of the variety Bartlett, which is mostly used for brandy production due to the high amounts of both esters eliciting a typical pear-like odor impression.

  17. New Physics Undercover at the LHC

    NASA Astrophysics Data System (ADS)

    Lou, Hou Keong

    With the completion of 7 TeV and 8 TeV data taking at the Large Hadron Collider (LHC), the physics community witnessed one of the great triumphs of modern physics: the completion of the Standard Model (SM) as an effective theory. The final missing particle, the Higgs boson, was observed and its mass was measured. However, many theoretical questions remain unanswered. What is the source of electroweak symmetry breaking? What is the nature of dark matter? How does gravity fit into the picture? With no definitive hints of new physics at the LHC, we must consider the possibility that our search strategies need to be expanded. Conventional LHC searches focus on theoretically motivated scenarios, such as the Minimal Supersymmetric Standard Models and Little Higgs Theories. However, it is possible that new physics may be entirely different from what we might expect. In this thesis, we examine a variety of scenarios that lead to new physics undercover at the LHC. First we look at potential new physics hiding in Quantum Chromo-Dynamics backgrounds, which may be uncovered using jet substructure techniques in a data-driven way. Then we turn to new long-lived particles hiding in Higgs decay, which may lead to displaced vertices. Such a signal can be unearthed through a data-driven analysis. Then we turn to new physics with ``semi-visible jets'', which lead to missing momentum aligned with jet momentum. These events are vetoed in traditional searches and we demonstrate ways to uncover these signals. Lastly, we explore performance of future colliders in two case studies: Stops and Higgs Portal searches. We show that a 100 TeV collider will lead to significant improvements over 14 TeV LHC runs. Indeed, new physics may lie undercover at the LHC and future colliders, waiting to be discovered.

  18. Calculating Total Electron Content under the presence of the Aurora Borealis in Fairbanks, Alaska, and Kiruna, Sweden.

    NASA Astrophysics Data System (ADS)

    Ahmad, H.; Ehteshami, A.; Edgar, B.

    2015-12-01

    With the presence of the ionosphere and plasmasphere interacting with geomagnetic storms, scattering effects can be seen by the signals sent to and by GPS/GLONASS satellites. To quantify this dispersive effect, scientists look into what the culprit is that causes this signal bias on an atomic level. Results have shown that the concentration of oscillating electrons is directly proportional to the amount of bias the signal from a point on earth to a GPS satellite witnesses. This is called the Total Electron Content (TEC) of a specified path, measured in electrons per meters squared (. In this project, the process of collecting and analyzing TEC units was kept the same as the previous methods while keeping the cost below $3,000. Using a dual-frequency GNSS receiver from Javad, Triumph-2, the project team recorded a series of 24 hour interval data logs as the receiver stored incoming signals from any reachable satellite. Because of the dispersive media in the ionosphere, the signal witnesses a bend in its path causing a delay, called the Slant TEC (sTEC). Using libraries from GPStk and TEQC, we analyzed RINEX files to view the differential phase and differential pseudorange frequency to compute slant TEC units (sTECU). Using the obtained data, we analyzed the difference between the sTEC units collected in Houston, Texas to the ones collected in Fairbanks, Alaska. Afterwards, the project will continue on another balloon in Kiruna, Sweden at the Esrange Space Center. The receiver will be in flight this time on a 48 hour flight.

  19. An ethical duty: Let astronautical development unfold - to make the people more secure

    NASA Astrophysics Data System (ADS)

    Bernasconi, Marco C.

    2014-11-01

    In examining alternative space-development models, one observes that Heinlein postulated the first Moon flight as the outcome of the focused action of an individual - building upon an ample commercial aerospace transportation infrastructure. The same technological basis and entrepreneurial drive would then sustain a fast human and economic expansion on three new planets. Instead, historically, humans reached the Moon thanks to a "Faustian bargain" between astronautical developers and governments. This approach brought the early Apollo triumphs, but it also created the presumption of this method as the sole one for enabling space development. Eventually, the application of this paradigm caused the decline of the astronautical endeavor. Thus, just as conventional methods became unable to sustain the astronautical endeavor, space development appeared as vital, e.g., to satisfy the people's basic needs (metabolic resources, energy, materials, and space), as shown elsewhere. Such an endeavor must grow from actions generating new wealth through commercial activities to become self-supporting. Acquisition and distribution of multiform space resources call, however, for a sound ethical environment, as predatory governments can easily forfeit those resources. The paper begins the search for means apt to maintain a societal environment suited for this purpose. Among numerous initiatives needed, dissemination of factual information and moral-right education support take a central position: In fact, the vital condition for true Astronautics - a vast increase in actual respect of moral rights - can also become its best consequence, as the prosperity from the space arena empowers the people, making them materially safer and more secure in their fundamental moral rights.

  20. Eurekas and Euphorias - The Oxford Book of Scientific Anecdotes

    NASA Astrophysics Data System (ADS)

    Gratzer, Walter

    2002-11-01

    The march of science has been marked through the years by episodes of drama and comedy, of failure as well as triumph, by outrageous strokes of luck, deserved and undeserved, and sometimes by human tragedy. In Eurekas and Euphorias , Walter Gratzer captures the human face of discovery as he relates many intriguing tales of scientific adventures spanning over two thousand years. Open this book at random and you may chance on the clumsy chemist named Sapper who broke a thermometer in a reaction vat and made the discovery that launched the modern dyestuff industry. Or the physicist who dissolved his gold Nobel Prize medal in acid to prevent it from falling into the hands of the Nazis. The book uncovers deep intellectual friendships, as well as ferocious animosities, and even acts of theft and malice, deceit, and a hoax or two. Indeed, we discover that scientists come in all shapes--the obsessive and the dilettantish, the genial, the envious, the preternaturally brilliant and the slow-witted who sometimes saw further in the end, the open-minded and the intolerant, recluses and arrivistes . We meet mathematicians and physicists in prison cells, and even in a madhouse, making important advances in their field. And we witness the careers, sometimes tragic, sometimes carefree, of the great women scientists, from Hypatia of Alexandria, to Sophie Germain and Sonia Kovalevskaya, to Marie Curie and her relentless battle with the French Academy. Told with wit and relish, here then is a glorious parade to delight the reader, with stories to astonish, to instruct, and most especially, to entertain.