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Sample records for rad-by-rad bit-by-bit triumph

  1. Rad-by-Rad (Bit-by-Bit): Triumph of Evidence Over Activities Fostering Fear of Radiogenic Cancers at Low Doses

    PubMed Central

    Strzelczyk, J.; Potter, W.; Zdrojewicz, Z.

    2007-01-01

    Large segments of Western populations hold sciences in low esteem. This trend became particularly pervasive in the field of radiation sciences in recent decades. The resulting lack of knowledge, easily filled with fear that feeds on itself, makes people susceptible to prevailing dogmas. Decades-long moratorium on nuclear power in the US, resentment of “anything nuclear”, and delay/refusal to obtain medical radiation procedures are some of the societal consequences. The problem has been exacerbated by promulgation of the linear-no-threshold (LNT) dose response model by advisory bodies such as the ICRP, NCRP and others. This model assumes no safe level of radiation and implies that response is the same per unit dose regardless of the total dose. The most recent (June 2005) report from the National Research Council, BEIR VII (Biological Effects of Ionizing Radiation) continues this approach and quantifies potential cancer risks at low doses by linear extrapolation of risk values obtained from epidemiological observations of populations exposed to high doses, 0.2 Sv to 3 Sv. It minimizes the significance of a lack of evidence for adverse effects in populations exposed to low doses, and discounts documented beneficial effects of low dose exposures on the human immune system. The LNT doctrine is in direct conflict with current findings of radiobiology and important features of modern radiation oncology. Fortunately, these aspects are addressed in-depth in another major report—issued jointly in March 2005 by two French Academies, of Sciences and of Medicine. The latter report is much less publicized, and thus it is a responsibility of radiation professionals, physicists, nuclear engineers, and physicians to become familiar with its content and relevant studies, and to widely disseminate this information. To counteract biased media, we need to be creative in developing means of sharing good news about radiation with co-workers, patients, and the general public. PMID:18648568

  2. BIT BY BIT: A Game Simulating Natural Language Processing in Computers

    ERIC Educational Resources Information Center

    Kato, Taichi; Arakawa, Chuichi

    2008-01-01

    BIT BY BIT is an encryption game that is designed to improve students' understanding of natural language processing in computers. Participants encode clear words into binary code using an encryption key and exchange them in the game. BIT BY BIT enables participants who do not understand the concept of binary numbers to perform the process of…

  3. Bit-by-bit autophagic removal of parkin-labelled mitochondria.

    PubMed

    Yang, Jin-Yi; Yang, Wei Yuan

    2013-01-01

    Eukaryotic cells maintain mitochondrial integrity through mitophagy, an autophagic process by which dysfunctional mitochondria are selectively sequestered into double-layered membrane structures, termed phagophores, and delivered to lysosomes for degradation. Here we show that small fragments of parkin-labelled mitochondria at omegasome-marked sites are engulfed by autophagic membranes one at a time. Using a light-activation scheme to impair long mitochondrial tubules, we demonstrate that sites undergoing bit-by-bit mitophagy display preferential ubiquitination, and are situated where parkin-labelled mitochondrial tubules and endoplasmic reticulum intersect. Our observations suggest contact regions between the endoplasmic reticulum and impaired mitochondria are initiation sites for local LC3 recruitment and mitochondrial remodelling that support bit-by-bit, parkin-mediated mitophagy. These results help in understanding how cells manage to fit large and morphologically heterogeneous mitochondria into micron-sized autophagic membranes during mitophagy.

  4. Bit-by-bit optical code scrambling technique for secure optical communication.

    PubMed

    Wang, Xu; Gao, Zhensen; Wang, Xuhua; Kataoka, Nobuyuki; Wada, Naoya

    2011-02-14

    We propose and demonstrate a novel bit-by-bit code scrambling technique based on time domain spectral phase encoding/decoding (SPE/SPD) scheme using only a single phase modulator to simultaneously generate and decode the code hopping sequence and DPSK data for secure optical communication application. In the experiment, 2.5-Gb/s DPSK data has been generated, decoded and securely transmitted over 34 km by scrambling five 8-chip, 20-Gchip/s Gold codes with prime-hop patterns. The proposed scheme can rapidly reconfigure the optical code hopping sequence bit-by-bit with the DPSK data, and thus it is very robust to conventional data rate energy detection and DPSK demodulation attack, exhibiting the potential to provide unconditional transmission security and realize even one-time pad.

  5. Based on reception in general with bit-by-bit decision-making algorithm for signal processing in fiber optic telecommunication systems

    NASA Astrophysics Data System (ADS)

    Burdin, Vladimir A.; Kartashevsky, Vyacheslav G.; Grigorov, Igor V.

    2016-03-01

    This paper presents «reception in general with bit-by-bit decision-making» algorithm, which is the alternative to Viterbi algorithm. It is proposed to use it for fiber-optic transmission systems. It's features is compared with the Viterbi algorithm for digital signal processing in optical communication channels.

  6. Rapid programmable/code-length-variable, time-domain bit-by-bit code shifting for high-speed secure optical communication.

    PubMed

    Gao, Zhensen; Dai, Bo; Wang, Xu; Kataoka, Nobuyuki; Wada, Naoya

    2011-05-01

    We propose and experimentally demonstrate a time-domain bit-by-bit code-shifting scheme that can rapidly program ultralong, code-length variable optical code by using only a dispersive element and a high-speed phase modulator for improving information security. The proposed scheme operates in the bit overlap regime and could eliminate the vulnerability of extracting the code by analyzing the fine structure of the time-domain spectral phase encoded signal. It is also intrinsically immune to eavesdropping via conventional power detection and differential-phase-shift-keying (DPSK) demodulation attacks. With this scheme, 10 Gbits/s of return-to-zero-DPSK data secured by bit-by-bit code shifting using up to 1024 chip optical code patterns have been transmitted over 49 km error free. The proposed scheme exhibits the potential for high-data-rate secure optical communication and to realize even one time pad.

  7. Bit by Bit: The Darwinian Basis of Life

    PubMed Central

    Joyce, Gerald F.

    2012-01-01

    All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered by the fact that the probability for life to originate is not known. As a guiding principle in parsing potential examples of alternative life, one should ask: How many heritable “bits” of information are involved, and where did they come from? A genetic system that contains more bits than the number that were required to initiate its operation might reasonably be considered a new form of life. PMID:22589698

  8. Bit by bit: the Darwinian basis of life.

    PubMed

    Joyce, Gerald F

    2012-01-01

    All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered by the fact that the probability for life to originate is not known. As a guiding principle in parsing potential examples of alternative life, one should ask: How many heritable "bits" of information are involved, and where did they come from? A genetic system that contains more bits than the number that were required to initiate its operation might reasonably be considered a new form of life.

  9. Bit by bit: the Darwinian basis of life.

    PubMed

    Joyce, Gerald F

    2012-01-01

    All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered by the fact that the probability for life to originate is not known. As a guiding principle in parsing potential examples of alternative life, one should ask: How many heritable "bits" of information are involved, and where did they come from? A genetic system that contains more bits than the number that were required to initiate its operation might reasonably be considered a new form of life. PMID:22589698

  10. Bit by Bit: Innovating at the Periphery to Extend Harvard's Core

    ERIC Educational Resources Information Center

    Laserna, Catalina; Leitner, Henry

    2008-01-01

    Faculty instructional time is a critical resource at all universities, but particularly in a major research institution like Harvard. Operating on the periphery of the Faculty of Arts and Sciences, Harvard's division of Continuing Education is often at a disadvantage when attempting to recruit senior faculty. However, through its distance…

  11. Bit by Bit: Using Design-Based Research to Improve the Health Literacy of Adolescents

    PubMed Central

    St. Jean, Beth; Taylor, Natalie Greene; Kodama, Christie; Follman, Rebecca; Casciotti, Dana

    2015-01-01

    Background Although a low health literacy level has been found to be among the most powerful predictors of poor health outcomes, there is very little research focused on assessing and improving the health literacy skills of adolescents, particularly those from socioeconomically disadvantaged backgrounds. The vast majority of existing research focuses solely on reading comprehension, despite the fact that health literacy is actually a multifaceted concept, which entails many different types of skills. Objective The aim of this paper is to first mine existing literature to identify the many different skills that have been posited to constitute health literacy, and then, using this collection of skills as an overarching structure, to highlight the challenges that disadvantaged youth participating in our HackHealth after-school program encounter as they identify and articulate their health-related information needs, search for health-related information online, assess the relevance and credibility of this information, and manage and make use of it. Methods We utilized the design-based research method to design, implement, and revise our HackHealth program. To collect data regarding HackHealth participants’ health literacy skills and associated challenges, we used a variety of methods, including participant observation, surveys, interviews, focus groups, and logging of Web browser activities. We also collected data through specialized instructional activities and data collection forms that we developed for this purpose. Quantitative and qualitative techniques were used to analyze this data, as well as all of the artifacts that each student produced, including their final projects. Results We identified the various challenges that the 30 HackHealth participants faced in completing various health-related information activities during the course of the program. Based on these findings, we describe important implications for working with youth from socioeconomically disadvantaged backgrounds, how to assess and improve their health literacy skills, and offer specific recommendations for health literacy instruction aimed at this population. Conclusions With an increased societal focus on health and a shift from viewing patients as passive recipients of medical care to viewing them as active arbiters of their own health, today’s youth need to possess an array of health literacy skills to ensure that they can live long and healthy lives. Working with adolescents to help them develop and practice these skills will also help to break the cycle between poor health literacy and poor health outcomes, thereby reducing health disparities and improving the long-term outlook for the health of our nation. PMID:26025101

  12. We Come to Form Ourselves Bit by Bit: Educating for Citizenship in Post-Conflict Guatemala

    ERIC Educational Resources Information Center

    Rubin, Beth C.

    2016-01-01

    Over the past several decades, the implementation of democratic citizenship education has become a common prescription for the civic reconstruction of post-conflict societies. Across the globe, educational changes are seen as fundamental to the creation of peaceful, tolerant, and democratic civic identities, the key to "social reconstruction,…

  13. Leadershock ... and How to Triumph over It

    ERIC Educational Resources Information Center

    Benzel, Brian L.

    2004-01-01

    The fundamental elements of leadership are not always evident in new challenges. Greg Hicks uses LeaderShock ... And How to Triumph Over It to remind leaders that the basics matter. Hicks, a business professor at San Jose State University and a trainer for Fortune 500 companies around the world, uses common sense, experience and excellent examples…

  14. Teaching Arturo Ui: Triumph of Whose Will?

    ERIC Educational Resources Information Center

    Rhiel, Mary

    1993-01-01

    Describes a unit on teaching Brecht in an introductory literature course, and suggests that students are better able to read and discuss Brecht's Hitler play if they first view and discuss Leni Riefenstahl's film Triumph of the Will. Guidelines are provided on how best to present and explore the two works with students. (LET)

  15. Portrait Gallery Illuminates--Grant's Triumphs, Failures.

    ERIC Educational Resources Information Center

    Lambert, Robert G., Jr.

    The 100th anniversary of Ulysses S. Grant's death was observed on July 23, 1985. The Smithsonian National Portrait Gallery featured an exhibit of Grant portraiture, which covered his life, from its humble beginnings to military and political triumphs and to failures and disappointment. The exhibit included pictures, artifacts, and momentos from…

  16. Oedipus and the sphinx: triumph and catastrophe.

    PubMed

    Palombo, S R

    1994-01-01

    The downfall of Oedipus in Sophocles' most famous play, Oedipus Tyrannus, is the reversal of his triumphant entry into the city of Thebes 17 years earlier. The oracle at Delphi has told the Thebans that the plague will end only when the murderer of Laius is identified and punished. The unconscious collusion between Oedipus and the Thebans to ignore the unsolved murder breaks down. Told by Teiresias that he is the culprit, Oedipus begins a desperate effort to find evidence to refute this accusation. When other witnesses come forward, his cause is lost. The effect of Oedipus's collusive interaction with the Thebans is balanced in Sophocles' account by the story of the riddle of the Sphinx. The Sphinx is a goddess of discontinuity. She represents the unconscious forces at work both in Oedipus's personal fantasies and in the collective fantasies of the Thebans. The tragedy results from the interaction of these fantasies in the government of the polis. Sophocles' play thus exemplifies the intricate intertwining of the child's innate wishes and the reaction they evoke from the environment during the oedipal period. The neurotic patient's illusion of sexual triumph over his or her father or mother as a child can be best understood through the interaction of these factors. PMID:8040558

  17. 8. VIEW OF 'TRIUMPH' CORN SHELLER (C. O. Bartlett & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF 'TRIUMPH' CORN SHELLER (C. O. Bartlett & Snow Co., Cleveland), LOCATED IN THE BASEMENT, USED TO REMOVE CORN KENNELS FROM THE COB. Photographer: Louise Taft Cawood, July 1986 - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

  18. "Triumph of the Will": A Limit Case for Effective-Historical Consciousness?

    ERIC Educational Resources Information Center

    Schwartzman, Roy

    A film presented as factual may permit critical responses that question its purported factual objectivity and political neutrality. In class, Hans-Georg Gadamer's concept of effective-historical consciousness can be used to evaluate the allegedly propagandistic messages in Leni Riefenstahl's "Triumph of the Will." Analysis of this 1934 film…

  19. Colonic irrigation and the theory of autointoxication: a triumph of ignorance over science.

    PubMed

    Ernst, E

    1997-06-01

    Autointoxication is an ancient theory based on the belief that intestinal waste products can poison the body and are a major contributor to many, if not all, diseases. In the 19th century, it was the ruling doctrine of medicine and led "colonic quackery" in various guises. By the turn of the century, it had received some apparent backing from science. When it became clear that the scientific rationale was wrong and colonic irrigation was not merely useless but potentially dangerous, it was exposed as quackery and subsequently went into a decline. Today we are witnessing a resurgence of colonic irrigation based on little less than the old bogus claims and the impressive power of vested interests. Even today's experts on colonic irrigation can only provide theories and anecdotes in its support. It seems, therefore, that ignorance is celebrating a triumph over science. PMID:9252839

  20. Lower urinary tract symptoms suggestive of benign prostatic obstruction--Triumph: health-economical analysis.

    PubMed

    McDonnell, J; Busschbach, J J; Kok, E; van Exel, J; Stolk, E; Koopmanschap, M; Rutten, F F

    2001-01-01

    Given the ageing of western populations, the cost burden associated with the treatment of LUTS suggestive of BPO will increase substantially over the next few decades. Therefore, from the economic perspective, the primary objective of the Triumph project is the assessment of the cost-effectiveness of treatment options for lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO), formerly referred to as symptomtic benign prostatic hyperplasia (BPH), in medical practice in initially six European countries. All modalities of LUTS treatment used in these countries will be considered. The effectiveness and costs associated with these treatments will be assessed in each country. Data will be gathered from observed medical practice rather than in the setting of a trial. Country-specific aspects will be studied and the outcome of country-specific policies can be predicted. Patient quality of life will also be measured using the I-PSS score as a basis. A number of treatment scenarios will be assessed in terms of both their costs and long-term effects, using a computer simulation. These economic analyses will provide greatly improved insight into the most cost-effective treatments for LUTS suggestive of BPO.

  1. "I Was Proud of Myself That I Didn't Give up and I Did It": Experiences of Pride and Triumph in Learning Science

    ERIC Educational Resources Information Center

    Bellocchi, Alberto; Ritchie, Stephen M.

    2015-01-01

    The role that specific emotions, such as pride and triumph, play during instruction in science education is an under researched field of study. Emotions are recognized as central to learning yet little is known about the way in which they are produced in naturalistic settings, how emotions relate to classroom learning during interactions, and what…

  2. The triumph and decline of the "squares": Grumman Aerospace engineers and production workers in the Apollo era, 1957--1973

    NASA Astrophysics Data System (ADS)

    Onkst, David Hugh

    This dissertation is a social, cultural, and economic history of the men and women of the Grumman Aerospace Company of Bethpage, New York from 1957 through 1973. These "Grummanites" were the engineers and production workers who designed and built the Apollo Lunar Modules that allowed humans to land on the Moon. This study provides unique insights into the impact that the Apollo Program---a large state-initiated and -supported program---had on those "squares," people whom many contemporaries saw as a vital part of mainstream 1960s American society. By the beginning of the Space Age in 1957, Grumman, Long Island's single largest employer, had firmly established a workplace culture of paternalism that Grummanites largely embraced. Company officials believed strongly in worker retention and had established a policy of providing every sort of benefit their employees seemingly desired, including a highly personal and participatory form of management. Many Grummanites had joined the firm during the early years of the Apollo Program because they believed in the promise of permanent employment on exciting projects that would explore the endless frontier of space. But, as many of these mainly self-reliant, individualistic "squares" would bitterly discover, their dedication to Grumman did little to secure their livelihoods during the aerospace industry's early 1970s downsizing; their individual successes were too largely tied to federal spending and declined when Americans grew disenchanted with space exploration. This dissertation demonstrates how the cultural bond of paternalism between aerospace workers and their company unraveled in the 1960s, and then ended in the early 1970s, because of forces within the company, the economy, and the American state. The word "triumph" in this study's title not only applies to Grummanites' triumphs with the Lunar Modules, but also their individual socioeconomic victories. The term "decline" refers to the early 1970s downsizing of more

  3. Utility of a Genetic Risk Score to Predict Recurrent Cardiovascular Events 1 Year After an Acute Coronary Syndrome: A Pooled Analysis of the RISCA, PRAXY, and TRIUMPH Cohorts

    PubMed Central

    Labos, Christopher; Martinez, Sara C.; Leo Wang, Rui Hao; Lenzini, Petra A.; Pilote, Louise; Bogaty, Peter; Brophy, James M.; Engert, James C.; Cresci, Sharon; Thanassoulis, George

    2015-01-01

    Background Limited evidence exists regarding the utility of genetic risk scores (GRS) in predicting recurrent cardiovascular events after acute coronary syndrome (ACS). We sought to determine whether a GRS would predict early recurrent cardiovascular events within 1 year of ACS. Methods & Results Participants admitted with acute coronary syndromes from the RISCA, PRAXY, and TRIUMPH cohorts, were genotyped for 30 single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) or myocardial infarction (MI) in prior genome wide association studies. A 30 SNP CAD/MI GRS was constructed. The primary endpoint was defined as all-cause mortality, recurrent ACS or cardiac re-hospitalization within 1 year of ACS admission. Results across all cohorts for the 30 SNP CAD/MI GRS were pooled using a random-effects model. There were 1040 patients from the RISCA cohort, 691 patients from the PRAXY cohort, and 1772 patients from the TRIUMPH cohort included in the analysis and 389 occurrences of the primary endpoint of recurrent events at 1-year post-ACS. In unadjusted and fully adjusted analyses, a 30 SNP GRS was not significantly associated with recurrent events (HR per allele 0.97 (95%CI 0.91–1.03) for RISCA, HR 0.99 (95%CI 0.93–1.05) for PRAXY, 0.98 (95%CI 0.94–1.02) for TRIUMPH, and 0.98 (95%CI 0.95–1.01) for the pooled analysis). Addition of this GRS to the GRACE risk model did not significantly improve risk prediction. Conclusion The 30 MI SNP GRS was not associated with recurrent events 1-year post ACS in pooled analyses across cohorts and did not improve risk discrimination or reclassification indices. Our results suggest that the genetic etiology of early events post-ACS may differ from later events. PMID:26232166

  4. 2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph.

    PubMed

    Meanwell, Nicholas A

    2016-08-25

    The development of direct-acting antiviral agents that can cure a chronic hepatitis C virus (HCV) infection after 8-12 weeks of daily, well-tolerated therapy has revolutionized the treatment of this insidious disease. In this article, three of Bristol-Myers Squibb's HCV programs are summarized, each of which produced a clinical candidate: the NS3 protease inhibitor asunaprevir (64), marketed as Sunvepra, the NS5A replication complex inhibitor daclatasvir (117), marketed as Daklinza, and the allosteric NS5B polymerase inhibitor beclabuvir (142), which is in late stage clinical studies. A clinical study with 64 and 117 established for the first time that a chronic HCV infection could be cured by treatment with direct-acting antiviral agents alone in the absence of interferon. The development of small molecule HCV therapeutics, designed by medicinal chemists, has been hailed as "the arc of a medical triumph" but may equally well be described as "the arc of a medicinal chemistry triumph". PMID:27501244

  5. A randomized crossover-design study to investigate the plaque removal efficacy of two power toothbrushes: Philips Sonicare Flexcare and Oral-B Triumph.

    PubMed

    Putt, Mark S; Milleman, Jeffery L; Jenkins, Wendy; Schmitt, Paul; Master, Aditi S; Strate, Joerg

    2008-01-01

    The Sonicare FlexCare and the Oral-B Triumph Professional Care 9000 power toothbrushes were compared in a single-use, examiner-masked, crossover clinical trial. Outcomes were evaluated using the Turesky Modified Quigley-Hein (TMQH) plaque index. Percent reduction in overall plaque score because of toothbrushing was the primary efficacy measure. Subjects were required to have a TMQH score > or = 1.8 at screening after refraining from oral hygiene for 24 hours. The study included three visits. At visit 1, subjects were randomized to one of two treatment sequences, given their first toothbrush and toothpaste, and instructed to use them twice daily for 2 minutes during a 1-week familiarization phase. Before visit 2, subjects again refrained from oral hygiene for 24 hours. At this visit, plaque scores were assessed before and after a 2-minute supervised brushing episode, then the second test product was issued. Familiarization, plaque accumulation, and clinical examinations were the same for both product use periods. Data were analyzed using a linear mixed effects model with subject as a grouping factor. Treatment effects were expressed as mean values and the appropriate 95% confidence intervals (CI). Ninety-six subjects were screened with 93 subjects completing the study. The sample's TMQH score at Visit 1 was 3.18 +/- 0.42 (mean +/- standard deviation [SD]). Full-mouth prebrushing plaque scores were 2.85 +/- 0.49 for FlexCare and 2.94 +/- 0.45 for Triumph. Respective full-mouth reductions in overall plaque score were 38.02% +/- 15.14% and 30.43% +/- 14.05%. The estimated treatment effect, expressed as difference between FlexCare and Triumph in percent plaque index reduction, was 7.59% with a 95% CI from 4.79% to 10.40%. Similar differences were observed for all subregions, including anterior, posterior, interproximal, and interproximal posterior sites. The same protocol design was used at an earlier study in another center. The combined overall treatment effect from

  6. A randomized crossover-design study to investigate the plaque removal efficacy of two power toothbrushes: Philips Sonicare Flexcare and Oral-B Triumph.

    PubMed

    Putt, Mark S; Milleman, Jeffery L; Jenkins, Wendy; Schmitt, Paul; Master, Aditi S; Strate, Joerg

    2008-01-01

    The Sonicare FlexCare and the Oral-B Triumph Professional Care 9000 power toothbrushes were compared in a single-use, examiner-masked, crossover clinical trial. Outcomes were evaluated using the Turesky Modified Quigley-Hein (TMQH) plaque index. Percent reduction in overall plaque score because of toothbrushing was the primary efficacy measure. Subjects were required to have a TMQH score > or = 1.8 at screening after refraining from oral hygiene for 24 hours. The study included three visits. At visit 1, subjects were randomized to one of two treatment sequences, given their first toothbrush and toothpaste, and instructed to use them twice daily for 2 minutes during a 1-week familiarization phase. Before visit 2, subjects again refrained from oral hygiene for 24 hours. At this visit, plaque scores were assessed before and after a 2-minute supervised brushing episode, then the second test product was issued. Familiarization, plaque accumulation, and clinical examinations were the same for both product use periods. Data were analyzed using a linear mixed effects model with subject as a grouping factor. Treatment effects were expressed as mean values and the appropriate 95% confidence intervals (CI). Ninety-six subjects were screened with 93 subjects completing the study. The sample's TMQH score at Visit 1 was 3.18 +/- 0.42 (mean +/- standard deviation [SD]). Full-mouth prebrushing plaque scores were 2.85 +/- 0.49 for FlexCare and 2.94 +/- 0.45 for Triumph. Respective full-mouth reductions in overall plaque score were 38.02% +/- 15.14% and 30.43% +/- 14.05%. The estimated treatment effect, expressed as difference between FlexCare and Triumph in percent plaque index reduction, was 7.59% with a 95% CI from 4.79% to 10.40%. Similar differences were observed for all subregions, including anterior, posterior, interproximal, and interproximal posterior sites. The same protocol design was used at an earlier study in another center. The combined overall treatment effect from

  7. Automation: triumph or trap?

    PubMed

    Smythe, M H

    1997-01-01

    Automation, a hot topic in the laboratory world today, can be a very expensive option. Those who are considering implementing automation can save time and money by examining the issues from the standpoint of an industrial/manufacturing engineer. The engineer not only asks what problems will be solved by automation, but what problems will be created. This article discusses questions that must be asked and answered to ensure that automation efforts will yield real and substantial payoffs.

  8. Nigeria's Triumph: Dracunculiasis Eradicated

    PubMed Central

    Miri, Emmanuel S.; Hopkins, Donald R.; Ruiz-Tiben, Ernesto; Keana, Adamu S.; Withers, P. Craig; Anagbogu, Ifeoma N.; Sadiq, Lola K.; Kale, Oladele O.; Edungbola, Luke D.; Braide, Eka I.; Ologe, Joshua O.; Ityonzughul, Cephas

    2010-01-01

    This report describes how Nigeria, a country that at one time had the highest number of cases of dracunculiasis (Guinea worm disease) in the world, reduced the number of cases from more than 653,000 in 1988 to zero in 2009, despite numerous challenges. Village-based volunteers formed the foundation of the program, which used health education, cloth filters, vector control, advocacy for safe water, voluntary isolation of patients, and monitored program interventions and cases reported monthly. Other factors in the program's success were strong governmental support, advocacy by a former head of state of Nigeria, technical and financial assistance by The Carter Center, the U.S. Centers for Disease Control and Prevention, the United Nations Children's Fund, the World Health Organization, and many other partners and donors. The estimated cost of the Nigerian program during 1988–2009 is $37.5 million, not including funding for water supply projects or salaries of Nigerian governmental workers. PMID:20682859

  9. Triumph in Tough Times

    ERIC Educational Resources Information Center

    Ponder, Anne

    2009-01-01

    The downturn in the economy of the author's state, North Carolina, so far is less severe than that of much of the rest of the nation, due to their diversified economy, financial discipline, constitutional mandate for a balanced budget, "rainy day" fund, and many years of consistent investment in higher education. In the University of North…

  10. Reason, Purpose & Triumph

    ERIC Educational Resources Information Center

    Johnson, Lincoln

    2010-01-01

    In this article, part of the Why I Teach essay series, the author shares how he developed his love for teaching and the failures and successes he experienced as a teacher. He used to hate teachers but everything changed when he entered college. He took general education classes and began to notice the difference between the great teachers and the…

  11. News Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

  12. A triumph of quiet diplomacy

    SciTech Connect

    Keeny, S.M. Jr.

    1994-11-01

    The new US agreement with North Korea is a breakthrough in the international effort to eliminate the most serious threat to the non-proliferation regime. Despite mutual mistrust, the two sides have, by quiet diplomacy, crafted an ingenious agreement that terminates Pyongyang`s current and future nuclear weapons program in return for economic benefits and an opportunity to join the international community.

  13. Triumph of the Voyager mission

    USGS Publications Warehouse

    Kerr, R. A.

    1989-01-01

    It had been a long, productive trip. Launched in 1977, the two Voyager spacecraft had visited three giant planets, a dozen major Moons, three ring systems with thousands of rings composed of a myriad of tiny Moonlets. The spacecraft had returned 5 trillion bits of data and over 100,000 photographs. The last encounter in our Solar System by Voyager 2 with Neptune was to be a spectacular finale to the 12-year drama. 

  14. Shell particles, trials, tribulations and triumphs

    SciTech Connect

    Guiochon, Georges A; Gritti, Fabrice

    2011-01-01

    The concept of pellicular particles was imagined by Horvath and Lipsky fifty years ago. They were initially intended for the analysis of macromolecules. Later, shell particles were prepared. The rational behind this concept was to improve column efficiency by shortening the pathways that analyte molecules must travel and, so doing, to improve their mass transfer kinetics. Several brands of superficially porous particles were developed and became popular in the 1970s. However, the major improvements in the manufacturing of high-quality, fully porous particles, that took place in the same time, particularly by making them finer and more homogeneous, hampered the success of shell particles, which eventually disappeared. Recently, the pressing needs to improve analytical throughputs forced particle manufacturers to find a better compromise between the demands for higher column efficiency that require short diffusion paths of analyte molecules in columns and the need for columns that can be operated with the conventional instruments for liquid chromatography, which operate with moderate column back-pressures. This lead to the apparition of a new generation of columns packed with shell particles, which bring chromatographic columns to a level of efficiency undreamed of a few years ago. This evolution is reviewed, the reason that motivated it, and the consequences of their success are discussed.

  15. Out of Trauma, Triumph and Courage

    ERIC Educational Resources Information Center

    Hughes, Marvalene

    2005-01-01

    When the unfathomable happened to Dillard University and other cherished institutions on the Gulf Coast on August 29, 2005, an act of nature ripped more than 1 million people from their comfort zones and thrust them into the unknown. They still have not had time to fully assess their personal losses, so intent have they been on focusing on their…

  16. Part Rally, Part Reunion, Total Triumph.

    ERIC Educational Resources Information Center

    Burns, Ann; And Others

    1992-01-01

    Reports on the 1992 National Conference of African American Librarians, sponsored by the Black Caucus of the American Library Association (ALA). Highlights include participants; programs on topics such as political issues, recruitment, and the involvement of African-American librarians in ALA; exhibitors; and a list of African-American library…

  17. Social Work's Future: Triumph or Disaster?

    ERIC Educational Resources Information Center

    Beck, Bertram M.

    1981-01-01

    Considers the social and political changes social workers may be faced with in the remainder of the century, and how the profession will react, in four scenarios. A national commission considering "future histories" describes possibilities ranging from heroism and expanded influence to loss of professional identity for social workers. (Author/JAC)

  18. Trials and Triumphs of Expanded Extension Programs.

    ERIC Educational Resources Information Center

    Leavengood, Scott; Love, Bob

    1998-01-01

    Oregon extension faced challenges in presenting programs in the wood products industry. Several traditional tactics, revised to suit a new audience, have proved successful: personal coaching, building partnerships, and providing a high level of service. Newer methods, such as database marketing and distance learning, are also proving to be…

  19. The Triumph of One-Dimensional Thinking.

    ERIC Educational Resources Information Center

    Shields, James J., Jr.

    1979-01-01

    Much of the confusion and nihilism that characterizes today's debates over educational policy can be explained by the tendency to view education, and indeed life, from a narrow and short-term perspective. This "either/or" mentality fails to account for the complexities and paradoxes in schooling and society. (Author/SJL)

  20. Level 5 leadership. The triumph of humility and fierce resolve.

    PubMed

    Collins, J

    2001-01-01

    Boards of directors typically believe that transforming a company from merely good to truly great requires a larger-than-life personality--an egocentric chief to lead the corporate charge. Think "Chainsaw" Al Dunlap or Lee Iacocca. In fact, that's not the case, says author and leadership expert Jim Collins. The essential ingredient for taking a company to greatness is having a "Level 5" leader at the helm--an executive in whom extreme personal humility blends paradoxically with intense professional will. Collins paints a compelling and counter-intuitive portrait of the skills and personality traits necessary for effective leadership. He identifies the characteristics common to Level 5 leaders: humility, will, ferocious resolve, and the tendency to give credit to others while assigning blame to themselves. Collins fleshes out his Level 5 theory by telling colorful tales about 11 such leaders from recent business history. He contrasts the turnaround successes of outwardly humble, even shy, executives like Gillette's Colman M. Mockler and Kimberly-Clark's Darwin E. Smith with those of larger-than-life business leaders like Dunlap and Iacocca, who courted personal celebrity. The jury is still out on how to cultivate Level 5 leaders and whether it's even possible to do so, Collins admits. Some leaders have the Level 5 seed within; some don't. But Collins suggests using the findings from his research to strive for Level 5--for instance, getting the right people on board and creating a culture of discipline. "Our own lives and all that we touch will be better for the effort," he concludes.

  1. The Rise and Triumph of the White House Photo Opportunity.

    ERIC Educational Resources Information Center

    Streitmatter, Rodger

    1988-01-01

    Measures the news coverage that has resulted from photo opportunities staged by United States presidents who have served since 1960. Finds that photo coverage of presidents in four major newspapers rose sixfold since 1960. (RS)

  2. Level 5 leadership. The triumph of humility and fierce resolve.

    PubMed

    Collins, J

    2001-01-01

    Boards of directors typically believe that transforming a company from merely good to truly great requires a larger-than-life personality--an egocentric chief to lead the corporate charge. Think "Chainsaw" Al Dunlap or Lee Iacocca. In fact, that's not the case, says author and leadership expert Jim Collins. The essential ingredient for taking a company to greatness is having a "Level 5" leader at the helm--an executive in whom extreme personal humility blends paradoxically with intense professional will. Collins paints a compelling and counter-intuitive portrait of the skills and personality traits necessary for effective leadership. He identifies the characteristics common to Level 5 leaders: humility, will, ferocious resolve, and the tendency to give credit to others while assigning blame to themselves. Collins fleshes out his Level 5 theory by telling colorful tales about 11 such leaders from recent business history. He contrasts the turnaround successes of outwardly humble, even shy, executives like Gillette's Colman M. Mockler and Kimberly-Clark's Darwin E. Smith with those of larger-than-life business leaders like Dunlap and Iacocca, who courted personal celebrity. The jury is still out on how to cultivate Level 5 leaders and whether it's even possible to do so, Collins admits. Some leaders have the Level 5 seed within; some don't. But Collins suggests using the findings from his research to strive for Level 5--for instance, getting the right people on board and creating a culture of discipline. "Our own lives and all that we touch will be better for the effort," he concludes. PMID:11189464

  3. Trials and Triumphs of Teaching Introduction to Native American Studies

    ERIC Educational Resources Information Center

    Johansen, Bruce Elliott

    2003-01-01

    Introduction to Native American Studies has been, paradoxically, the author's most satisfying and most challenging teaching assignment in more than two decades as a university-level faculty member. As a former coordinator of the Native American Studies Program at the University of Nebraska at Omaha (UNO), he has heard many other faculty air their…

  4. Listening, talking triumph in promoting effective public involvement

    SciTech Connect

    Forrest, C.J.; Michaud, G.R.

    1995-07-01

    When added to situations involving formal Superfund cleanups, RCRA permitting and other environmental issues, it is clear that understanding how to handle community concerns is rapidly becoming a necessity for many businesses. The terms public involvement, public participation and community relations all embody the same concept--establishing a dialogue with members of the public who are affected by environmental permitting, a contaminated site or other environmental issues. The goal of the dialogue is to promote public understanding about a project or issue, and ensure that citizens` concerns are considered and thoroughly addressed. Public concerns often are magnified by lack of information, misinformation or false information about an environmental issue. Failing to acknowledge concerns and provide appropriate information can lead to community resistance. In their extreme forms, such communications failures have slowed or blocked the permitting process, and even halted removal of hazardous wastes from residential and nonresidential areas. Community relations requirements under the Comprehensive Environmental Response, Compensation and Liability Act, and public participation requirements under the Resource Conservation and Recovery Act are intended to promote positive dialogue. In both cases, core activities and their timing are set by regulation.

  5. An Early Childhood Professional Development School: Triumphs and Troubles.

    ERIC Educational Resources Information Center

    Morse, Sheila; And Others

    This paper presents a case study of a collaboration between the St. Louis (Missouri) Public Schools and Maryville University (Missouri) to develop an early childhood magnet center and professional development school (PDS), the Wilkinson Early Childhood Magnet School. This school serves a diverse population of children from age 3 through second…

  6. Project Physics Text 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Mechanical theories are presented in this unit of the Project Physics text for senior high students. Collisions, Newton's laws, isolated systems, and Leibniz' concept are discussed, leading to conservation of mass and momentum. Energy conservation is analyzed in terms of mechanical energy, heat energy, steam engines, Watt's engine, Joule's…

  7. Project Physics Reader 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    As a supplement to Project Physics Unit 3, a collection of articles is presented in this reader for student browsing. Four excerpts are given under the following headings: On the kinetic theory of gases, Maxwell's Demon, Introduction to Waves, and Scientific Cranks. Five articles are included in terms of energy, barometers, randomness, fiddle…

  8. Vaccinations: A public health triumph and a public relations tragedy.

    PubMed

    Jacobson, Robert M

    2012-08-01

    Routine vaccination has been hailed as one of the top public health achievements of the last century. However, despite the reduced number of cases of and deaths from vaccine-preventable diseases such as pertussis and measles, outbreaks continue to occur as more parents fail to adequately vaccinate their children because of misinformation about immunizations. This article describes the challenges of making sure all children in the United States are fully immunized and what physicians need to know to effectively work with parents who may be hesitant to vaccinate their children.

  9. The Plus 50 Population in Higher Education: Challenges and Triumphs

    ERIC Educational Resources Information Center

    Barr, Jason

    2016-01-01

    As the economy in the United States continues to emerge from a recession and as jobs become more technologically advanced rendering other jobs obsolete, more and more Americans over the age of 50 are now attending college for a variety of reasons. Around 77% of the so-called Plus 50 students were enrolled in two-year public institutions. Other…

  10. Project Physics Teacher Guide 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Teaching procedures of Project Physics Unit 3 are presented to help teachers make effective use of learning materials. Unit contents are discussed in connection with teaching aid perspective, multi-media schedules, schedule blocks, and resource charts. Brief analyses are made for transparencies, 16mm films, and reader articles. Included is…

  11. Challenges and Triumphs to Genomics-Based Natural Product Discovery

    PubMed Central

    Jensen, Paul R.; Chavarria, Krystle L.; Fenical, William; Moore, Bradley S.; Ziemert, Nadine

    2013-01-01

    Genome sequencing is rapidly changing the field of natural products research by providing opportunities to assess the biosynthetic potential of strains prior to chemical analysis or biological testing. Ready access to sequence data is driving the development of new bioinformatic tools and methods to identify the products of silent or cryptic pathways. While genome mining has fast become a useful approach to natural product discovery, it has also become clear that identifying pathways of interest is much easier than finding the associated products. This has led to bottlenecks in the discovery process that must be overcome for the potential of genomics-based natural product discovery to be fully realized. In this perspective, we address some of these challenges in the context of our work with the marine actinomycete genus Salinispora, which is proving to be a useful model with which to apply genome mining as an approach to natural product discovery. PMID:24104399

  12. From Tragedy to Triumph - Rebuilding Green Buildings after Disaster

    SciTech Connect

    2009-10-01

    Fact sheet offering practical information about building energy efficient buildings and using renewable energy. Includes a checklist and resources. Highlights successful projects in Greensburg, Kansas.

  13. Integrating the Study of the Holocaust: One School's Triumph

    ERIC Educational Resources Information Center

    Ruder, Robert

    2005-01-01

    Integrating the study of the Holocaust into the middle school curriculum is a formidable challenge. This article describes the approach taken by Whitwell Middle School in Tennessee: When teachers found that students were having a difficult time comprehending the number of Jews and others killed by the Nazis, they decided to have the students…

  14. Profitable failure: antidepressant drugs and the triumph of flawed experiments.

    PubMed

    McGoey, Linsey

    2010-01-01

    Drawing on an analysis of Irving Kirsch and colleagues' controversial 2008 article in "PLoS [Public Library of Science] Magazine" on the efficacy of SSRI antidepressant drugs such as Prozac, I examine flaws within the methodologies of randomized controlled trials (RCTs) that have made it difficult for regulators, clinicians and patients to determine the therapeutic value of this class of drug. I then argue, drawing analogies to work by Pierre Bourdieu and Michael Power, that it is the very limitations of RCTs -- their inadequacies in producing reliable evidence of clinical effects -- that help to strengthen assumptions of their superiority as methodological tools. Finally, I suggest that the case of RCTs helps to explore the question of why failure is often useful in consolidating the authority of those who have presided over that failure, and why systems widely recognized to be ineffective tend to assume greater authority at the very moment when people speak of their malfunction.

  15. Manipulating neural activity in physiologically classified neurons: triumphs and challenges.

    PubMed

    Gore, Felicity; Schwartz, Edmund C; Salzman, C Daniel

    2015-09-19

    Understanding brain function requires knowing both how neural activity encodes information and how this activity generates appropriate responses. Electrophysiological, imaging and immediate early gene immunostaining studies have been instrumental in identifying and characterizing neurons that respond to different sensory stimuli, events and motor actions. Here we highlight approaches that have manipulated the activity of physiologically classified neurons to determine their role in the generation of behavioural responses. Previous experiments have often exploited the functional architecture observed in many cortical areas, where clusters of neurons share response properties. However, many brain structures do not exhibit such functional architecture. Instead, neurons with different response properties are anatomically intermingled. Emerging genetic approaches have enabled the identification and manipulation of neurons that respond to specific stimuli despite the lack of discernable anatomical organization. These approaches have advanced understanding of the circuits mediating sensory perception, learning and memory, and the generation of behavioural responses by providing causal evidence linking neural response properties to appropriate behavioural output. However, significant challenges remain for understanding cognitive processes that are probably mediated by neurons with more complex physiological response properties. Currently available strategies may prove inadequate for determining how activity in these neurons is causally related to cognitive behaviour.

  16. Saving the Dust Bowl: "Big Hugh" Bennett's Triumph over Tragedy

    ERIC Educational Resources Information Center

    Smith, Rebecca

    2007-01-01

    In the 1930s, years of injudicious cultivation had devastated 100 million acres of Kansas, Oklahoma, Texas, Colorado, and New Mexico. This was the Dust Bowl, and it exposed a problem that had silently plagued American agriculture for centuries--soil erosion. Farmers, scientists, and the government alike considered it trivial until Hugh Hammond…

  17. Project Physics Handbook 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Ten experiments and 27 activities are presented in this handbook. The experiments are related to collisions, energy conservation, speed measurements, thermometry, calorimetry, gas properties, wave motions, and acoustic problems. The activities are concerned with stroboscopic photographs in collision, elastic impact, mass conservation, exchange of…

  18. Project Physics Tests 3, The Triumph of Mechanics.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    Test items relating to Project Physics Unit 3 are presented in this booklet. Included are 70 multiple-choice and 20 problem-and-essay questions. Concepts of mechanics are examined on energy, momentum, kinetic theory of gases, pulse analyses, "heat death," water waves, power, conservation laws, normal distribution, thermodynamic laws, and wave…

  19. Resisting Reading Mandates: How To Triumph with the Truth.

    ERIC Educational Resources Information Center

    Garan, Elaine M.

    Teachers today are in a stranglehold as a glut of mandates and standards restrict their ability to make decisions in their own classrooms. In many schools, scripted, regimented commercial programs further erode their power to view their students as individuals with unique talents and needs. Even the words they use "to teach" are no longer their…

  20. Triumphs and Tribulations of WRF-Chem Development and Use

    SciTech Connect

    Gustafson, William I.; Fast, Jerome D.; Easter, Richard C.; Ghan, Steven J.

    2005-06-27

    In order to address scientific questions related to aerosol chemistry and meteorological-aerosol-radiation-cloud feedbacks at the urban to regional scale, scientists at the Pacific Northwest National Laboratory (PNNL) have made substantial contributions to the chemistry version of the Weather Research and Forecasting model (WRF-Chem) during the past one and a half years. These contributions include an additional gas-phase chemistry mechanism, a sectional aerosol module, an additional photolysis module, feedbacks between aerosols and radiation, and extending the nesting capability of WRF to include the chemistry scalars. During the development process, a number of limitations in WRF have been identified that complicate adding all the desired chemistry capabilities as originally planned. These issues will be discussed along with changes that have been made to help mitigate some of them. Mechanisms currently in development will also be discussed including a secondary organic aerosol (SOA) mechanism for the sectional aerosol module, aqueous chemistry, and the aerosol indirect effect.

  1. Trial, Error, Triumph: A College Rethinks Its Core Curriculum

    ERIC Educational Resources Information Center

    Jordan-Fleming, Mary Kay; Klabunde, Michael; Zane, Cynthia

    2005-01-01

    Promoting student learning can be difficult, even at a liberal arts and sciences college where faculty members are passionate about it. The authors have experienced these challenges at the College of Mount St. Joseph in the last five years as they have moved collegewide efforts more intentionally toward facilitation of learning. The College of…

  2. The World Medical Association: can hope triumph over experience?

    PubMed Central

    Richards, T.

    1994-01-01

    The World Medical Association was set up in 1947 in the wake of outrage about war crimes committed by doctors in Hitler's Germany. For nearly 50 years it has lurched from one controversy to another, arguing within itself about its funding, its voting system, and the representativeness and political affiliation of some of its member medical associations. The BMA withdrew from the association in 1984, supporting a breakaway "Toronto" group including Canada, the Scandinavian countries, the Netherlands, Ireland, and Jamaica. All but Britain and Jamaica have now rejoined and membership is growing, but the association is still struggling to gain credibility and clout. After 20 years of part time stewardship the recent appointment of a new full time secretary general has fuelled expectations that internal reforms will be implemented, and the WMA's standing and profile improved. PMID:8111265

  3. American style or Turkish chair: the triumph of bodily comfort.

    PubMed

    Çevik, Gülen

    2010-01-01

    This article investigates the reciprocal influence of Ottoman Turkish and American interiors in the development of seating furniture. Seating furniture is unique because it involves a direct and physical interaction between the piece of furniture and the body, while at the same time it is part of a public space where social interactions occur. I will argue that the interactions between the Ottoman Turks and Americans are reflected in the way these traditions modified their seating furniture as they sought to mediate cultural, political and social differences between them. The concept of bodily comfort will serve as a common thread in understanding the origin of the expression "American style" (Amerikan stili or Amerikan tarzı) in modern Turkish language, the "Turkish chairs" in Victorian America in the late nineteenth century and the English language use of words such as sofa, ottoman and divan.

  4. Vaccinations: A public health triumph and a public relations tragedy.

    PubMed

    Jacobson, Robert M

    2012-08-01

    Routine vaccination has been hailed as one of the top public health achievements of the last century. However, despite the reduced number of cases of and deaths from vaccine-preventable diseases such as pertussis and measles, outbreaks continue to occur as more parents fail to adequately vaccinate their children because of misinformation about immunizations. This article describes the challenges of making sure all children in the United States are fully immunized and what physicians need to know to effectively work with parents who may be hesitant to vaccinate their children. PMID:22953473

  5. American style or Turkish chair: the triumph of bodily comfort.

    PubMed

    Çevik, Gülen

    2010-01-01

    This article investigates the reciprocal influence of Ottoman Turkish and American interiors in the development of seating furniture. Seating furniture is unique because it involves a direct and physical interaction between the piece of furniture and the body, while at the same time it is part of a public space where social interactions occur. I will argue that the interactions between the Ottoman Turks and Americans are reflected in the way these traditions modified their seating furniture as they sought to mediate cultural, political and social differences between them. The concept of bodily comfort will serve as a common thread in understanding the origin of the expression "American style" (Amerikan stili or Amerikan tarzı) in modern Turkish language, the "Turkish chairs" in Victorian America in the late nineteenth century and the English language use of words such as sofa, ottoman and divan. PMID:21114093

  6. Turmoil and triumph: My years as secretary of state

    SciTech Connect

    Schultz, G.P.

    1993-12-31

    The Reagan administration, or members of it, may have believed their own propaganda about the United States (U.S.) military weakness in 1980 and 1981, but the Soviet leaders never did. Nor did they ever doubt or challenge U.S. deterrence or determination to repel agression against the U.S. or its allies. What was new was a belated recognition by Moscow`s leaders that the Marxist-Lennist world view they had held for 70 years did not accord with reality, and that their combined efforts to apply that pattern for internal development did not accord with the real needs of society. It was a remarkable turn of policy in Reagan`s second term that led to five summit meetings, as many as in the preceding three presidencies, and One-third of all the postwar, Cold War summits. One of the most interesting and valuable contributions of this book is the picture of the inner workings of the Reagan administration, as seen by the secretary of state.

  7. Triumphs Show: Taking Students outside the Classroom "inside" the Classroom

    ERIC Educational Resources Information Center

    Osowiecki, Maria; Francis, Robin

    2014-01-01

    Year 9 think they know a lot about the First World War. After all, they read Michael Morpurgo's novel Private Peaceful in their English lessons all the way back in Year 7, they have seen Blackadder so many times they can recite it, and in the centenary year of the war's outbreak, they can hardly avoid it on television. But their view of…

  8. Manipulating neural activity in physiologically classified neurons: triumphs and challenges

    PubMed Central

    Gore, Felicity; Schwartz, Edmund C.; Salzman, C. Daniel

    2015-01-01

    Understanding brain function requires knowing both how neural activity encodes information and how this activity generates appropriate responses. Electrophysiological, imaging and immediate early gene immunostaining studies have been instrumental in identifying and characterizing neurons that respond to different sensory stimuli, events and motor actions. Here we highlight approaches that have manipulated the activity of physiologically classified neurons to determine their role in the generation of behavioural responses. Previous experiments have often exploited the functional architecture observed in many cortical areas, where clusters of neurons share response properties. However, many brain structures do not exhibit such functional architecture. Instead, neurons with different response properties are anatomically intermingled. Emerging genetic approaches have enabled the identification and manipulation of neurons that respond to specific stimuli despite the lack of discernable anatomical organization. These approaches have advanced understanding of the circuits mediating sensory perception, learning and memory, and the generation of behavioural responses by providing causal evidence linking neural response properties to appropriate behavioural output. However, significant challenges remain for understanding cognitive processes that are probably mediated by neurons with more complex physiological response properties. Currently available strategies may prove inadequate for determining how activity in these neurons is causally related to cognitive behaviour. PMID:26240431

  9. The post-cold war settlement in Europe: A triumph of arms control

    SciTech Connect

    Mandelbaum, M.

    1997-03-01

    {open_quotes}The military capabilities of the countries of Europe are also less threatening now than in the past, and this has been accomplished by arms control.{close_quotes} The author argues that there is a new security order in place in Europe, one that differs from the two most familiar ways of organizing security: balance-of-power politics and world government. Balance-of-power politics has been the source of such stability as Europe has enjoyed for most of its recorded history, including during the Cold War years. World government is a utopian dream that has been envisioned and advocated but never implemented, and that might not be a source of celebration if it were implemented, which it almost surely will not be. The theme of The Dawn of Peace in Europe is that, in the wake of the Cold War, Europe has established a third method for achieving security, called common security and that owes something to the concept of cooperative security that was developed at the Brookings Institution. Within this common security regime, Europe is still made up of soverign states. There is no supranational authority. The states of Europe are still armed. But peace in Europe does not depend-as it has for most of Europe`s recorded history-on a finely balanced hostility between and among the most powerful European nations. The new common security order has dramatically reduced both the incentives and the capabilities for war.

  10. Human Error and the International Space Station: Challenges and Triumphs in Science Operations

    NASA Technical Reports Server (NTRS)

    Harris, Samantha S.; Simpson, Beau C.

    2016-01-01

    Any system with a human component is inherently risky. Studies in human factors and psychology have repeatedly shown that human operators will inevitably make errors, regardless of how well they are trained. Onboard the International Space Station (ISS) where crew time is arguably the most valuable resource, errors by the crew or ground operators can be costly to critical science objectives. Operations experts at the ISS Payload Operations Integration Center (POIC), located at NASA's Marshall Space Flight Center in Huntsville, Alabama, have learned that from payload concept development through execution, there are countless opportunities to introduce errors that can potentially result in costly losses of crew time and science. To effectively address this challenge, we must approach the design, testing, and operation processes with two specific goals in mind. First, a systematic approach to error and human centered design methodology should be implemented to minimize opportunities for user error. Second, we must assume that human errors will be made and enable rapid identification and recoverability when they occur. While a systematic approach and human centered development process can go a long way toward eliminating error, the complete exclusion of operator error is not a reasonable expectation. The ISS environment in particular poses challenging conditions, especially for flight controllers and astronauts. Operating a scientific laboratory 250 miles above the Earth is a complicated and dangerous task with high stakes and a steep learning curve. While human error is a reality that may never be fully eliminated, smart implementation of carefully chosen tools and techniques can go a long way toward minimizing risk and increasing the efficiency of NASA's space science operations.

  11. The Triumph of the Will: An Exploration of Certain Fundamental Problematics in Administrative Philosophy.

    ERIC Educational Resources Information Center

    Hodgkinson, Christopher

    1997-01-01

    Revisits some elusive concepts in administrative thought, particularly the notions of will, intention, consciousness, value, and depth motivation. Proposes a curriculum reform direction that substitutes axiological for current epistemological preoccupations. A directional shift is necessary for administration, because the leadership function can…

  12. The Rise, Fall and Subsequent Triumph of Thalidomide: Lessons Learned in Drug Development

    PubMed Central

    Rehman, Waqas; Arfons, Lisa M.; Lazarus, Hillard M.

    2011-01-01

    Perhaps no other drug in modern medicine rivals the dramatic revitalization of thalidomide. Originally marketed as a sedative, thalidomide gained immense popularity worldwide among pregnant women because of its effective anti-emetic properties in morning sickness. Mounting evidence of human teratogenicity marked a dramatic fall from grace and led to widespread social, legal and economic ramifications. Despite its tragic past thalidomide emerged several decades later as a novel and highly effective agent in the treatment of various inflammatory and malignant diseases. In 2006 thalidomide completed its remarkable renaissance becoming the first new agent in over a decade to gain approval for the treatment of plasma cell myeloma. The catastrophic collapse yet subsequent revival of thalidomide provides important lessons in drug development. Never entirely abandoned by the medical community, thalidomide resurfaced as an important drug once the mechanisms of action were further studied and better understood. Ongoing research and development of related drugs such as lenalidomide now represent a class of irreplaceable drugs in hematological malignancies. Further, the tragedies associated with this agent stimulated the legislation which revamped the FDA regulatory process, expanded patient informed consent procedures and mandated more transparency from drug manufacturers. Finally, we review recent clinical trials summarizing selected medical indications for thalidomide with an emphasis on hematologic malignancies. Herein, we provide a historic perspective regarding the up-and-down development of thalidomide. Using PubMed databases we conducted searches using thalidomide and associated keywords highlighting pharmacology, mechanisms of action, and clinical uses. PMID:23556097

  13. African-American Firsts. Famous, Little-Known and Unsung Triumphs of Blacks in America.

    ERIC Educational Resources Information Center

    Potter, Joan; Claytor, Constance

    Stories of more than 400 "firsts" by African Americans, break-through achievements in a variety of fields, are told in question-and-answer form ("Who was the first African American to ...?"). These are stories of people who were forced to contend with racism, directly or indirectly, in their struggle towards goals that require dedication and…

  14. Piecing Together the Roman Empire: A Story of Discovery and Triumph.

    ERIC Educational Resources Information Center

    Richmond, Julie A.; And Others

    This story, written by middle school students and their teacher at Kingsbury School in Michigan, concerns the Ancient Roman Empire and is designed to be used to teach other middle school students. The story depicts a quest to reconstruct the Roman Empire from its beginnings as Ancient Italy, as a republic in the sixth century B.C., to the height…

  15. Social Determinants and Disparities in Health: Their Crucifixion, Resurrection, and Ultimate Triumph(?) in Health Policy.

    PubMed

    House, James S

    2016-08-01

    David Mechanic has been a principal founder of modern sociological and social science approaches to health, especially in relation to health policy. These approaches have since the 1950s and 1960s resurrected ideas that had currency in the mid-nineteenth century but seemed crucified, dead, and buried by the rise of modern biomedicine from the mid-nineteenth century through the mid-twentieth century. Problems and lacunae in purely biomedical approaches to health in the later twentieth century, along with developments of new biopsychosocial approaches to health, have spawned a return toward ideas of Rudolf Virchow and mid-nineteenth-century social medicine that social determinants and disparities are major drivers of population health. Since individual health and population health constitute the major determinants of health care utilization and expenditures, social determinants and disparities in health are arguably the foundation of a new "demand-side" health policy that can resolve America's paradoxical health policy crisis of spending increasingly more than any nation on health care and insurance yet achieving increasingly worsening health outcomes relative to virtually all developed countries and some developing ones as well, something that current "supply-side" health policy, including Obamacare, cannot do, important as it is for expanding access to health insurance and care.

  16. Russian war surgery in 1812: 200 years since Russia's war triumph.

    PubMed

    Boсkeria, Leo A; Glyantsev, Sergey P; Kolesnikov, Yan G

    2012-01-01

    Specific wounds inflicted on soldiers and officers of the Russian Army by French firearms and cold weapon and wound treatment by Russian surgeons during 1812 Napoleon's invasion (better known in Russia as the Patriotic War of 1812) are discussed. An inference is made that the then surgical treatment was not only administered at a high level but was also versatile and efficient and thus could make a certain contribution to the victory of the Russian arms. PMID:23151528

  17. The triumph of the segregationists? A historiographical inquiry into psychology and the Brown litigation.

    PubMed

    Jackson, J P

    2000-08-01

    Psychologists testified at the trials of Brown v. Board of Education and helped write briefs that were submitted to the Supreme Court on appeal. Psychologists were once proud of what they did in Brown but are now seen as liberal reformers who masked their political wishes in the guise of social science. The argument that psychologists involved with Brown were social reformers rather than objective scientists dates to the segregationist critique of Brown. The author traces the history of the critique of the Brown psychologists from its segregationist origins to its acceptance by mainstream social scientific and historical scholars. The author concludes that the critique is based on a misreading of what the Brown psychologists did during the litigation.

  18. Reported masculinity ratio in Pakistan: a triumph of anthropology and economics over biology.

    PubMed

    Krotki, K J

    1985-01-01

    Reported sex ratios in Pakistan for the 1960s and 1970s are examined, and attempts at explaining the findings are presented. Available data, including census- and survey-reported sex ratios, are considered. Attention is given to sex ratios at birth, expected age-specific sex ratios, and implied versus reported sex ratios at death. Conclusions concerning sex differentials in mortality at selected ages are summarized. In a final section, the author considers the relationship of sex ratios to sex roles. Comments by Syeda Abida Hussain are included (pp. 298-303).

  19. The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future

    PubMed Central

    Tseng, Alice; Seet, Jason; Phillips, Elizabeth J

    2015-01-01

    The evolution of human immunodeficiency virus (HIV) treatment has improved our understanding and management of complex pharmacological issues that have driven improved outcomes and quality of life of the HIV-infected patient. These issues include adherence, long- and short-term toxicities, pharmacoenhancement, pharmacogenomics, therapeutic drug monitoring, differential penetration of drugs into sanctuary sites, such as the central nervous system, genital tract and small bowel, and drug–drug and drug–food interactions related to cytochrome P450 drug-metabolizing enzymes, uridine diphosphate glucuronyltransferases and drug transporters, to name a few. There is future promise, as an increased understanding of the immunopathogenesis of HIV and global public health initiatives are driving novel treatment approaches with goals to prevent, control and, ultimately, eradicate HIV. PMID:24730660

  20. Anatomy of a Municipal Triumph: New York City's Upsurge in Life Expectancy

    PubMed Central

    Preston, Samuel H.; Elo, Irma T.

    2014-01-01

    Over the period 1990–2010, the increase in life expectancy for males in New York City was 6.0 years greater than for males in the United States. The female relative gain was 3.9 years. Male relative gains were larger because of extremely rapid reductions in mortality from HIV/AIDS and homicide, declines that reflect effective municipal policies and programs. Declines in drug- and alcohol-related deaths also played a significant role in New York City's advance, but every major cause of death contributed to its relative improvement. By 2010, New York City had a life expectancy that was 1.9 years greater than that of the US. This difference is attributable to the high representation of immigrants in New York's population. Immigrants to New York City, and to the United States, have life expectancies that are among the highest in the world. The fact that 38 percent of New York's population consists of immigrants, compared to only 14 percent in the United States, accounts for New York's exceptional standing in life expectancy in 2010. In fact, US-born New Yorkers have a life expectancy below that of the United States itself. PMID:25843989

  1. Persephone's Triumph: Reflections of a Young Black Woman Becoming a Real Political Scientist

    ERIC Educational Resources Information Center

    Brown, Ruth Nicole

    2007-01-01

    This article is a poetic retelling of insight gained as a Black woman surviving graduate school. The purpose of this autoethnographic narrative is to document a few pivotal graduate school experiences that illustrate all that it means to become disciplined in and by higher education. Although the violence committed in such a privileged space may…

  2. Flat-panel electronic displays: a triumph of physics, chemistry and engineering.

    PubMed

    Hilsum, Cyril

    2010-03-13

    This paper describes the history and science behind the development of modern flat-panel displays, and assesses future trends. Electronic displays are an important feature of modern life. For many years the cathode ray tube, an engineering marvel, was universal, but its shape was cumbersome and its operating voltage too high. The need for a flat-panel display, working at a low voltage, became imperative, and much research has been applied to this need. Any versatile flat-panel display will exploit an electro-optical effect, a transparent conductor and an addressing system to deliver data locally. The first need is to convert an electrical signal into a visible change. Two methods are available, the first giving emission of light, the second modulating ambient illumination. The most useful light-emitting media are semiconductors, historically exploiting III-V or II-VI compounds, but more recently organic or polymer semiconductors. Another possible effect uses gas plasma discharges. The modulating, or subtractive, effects that have been studied include liquid crystals, electrophoresis, electrowetting and electrochromism. A transparent conductor makes it possible to apply a voltage to an extended area while observing the results. The design is a compromise, since the free electrons that carry current also absorb light. The first materials used were metals, but some semiconductors, when heavily doped, give a better balance, with high transmission for a low resistance. Delivering data unambiguously to a million or so picture elements across the display area is no easy task. The preferred solution is an amorphous silicon thin-film transistor deposited at each cross-point in an X-Y matrix. Success in these endeavours has led to many applications for flat-panel displays, including television, flexible displays, electronic paper, electronic books and advertising signs.

  3. The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

    PubMed Central

    Cifuentes-Pagano, Eugenia; Meijles, Daniel N.

    2014-01-01

    Abstract Significance: Numerous studies in animal models and human subjects corroborate that elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of multiple diseases. As a major source of ROS in many organ systems, the NADPH oxidase (Nox) has become a prime target for therapeutic development. Recent Advances: In recent years, intense efforts have been dedicated to the development of pan- and isoform-specific Nox inhibitors as opposed to antioxidants that proved ineffective in clinical trials. Over the past decade, an array of compounds has been proposed in an attempt to fill this void. Critical Issues: Although many of these compounds have proven effective as Nox enzyme family inhibitors, isoform specificity has posed a formidable challenge to the scientific community. This review surveys the most prominent Nox inhibitors, and discusses potential isoform specificity, known mechanisms of action, and shortcomings. Some of these inhibitors hold substantial promise as targeted therapeutics. Future Directions: Increased insight into the mechanisms of action and regulation of this family of enzymes as well as atomic structures of key Nox subunits are expected to give way to a broader spectrum of more potent, efficacious, and specific molecules. These lead molecules will assuredly serve as a basis for drug development aimed at treating a wide array of diseases associated with increased Nox activity. Antioxid. Redox Signal. 20, 2741–2754. PMID:24070014

  4. From Tragedy to Triumph - Rebuilding Green Buildings after Disaster, EERE (Fact Sheet)

    SciTech Connect

    Not Available

    2009-10-01

    Fact sheet offering practical information about building energy efficient buildings and using renewable energy. Includes a checklist and resources. Highlights successful projects in Greensburg, Kansas.

  5. From Tragedy to Triumph - Rebuilding Green Homes after Disaster (Fact Sheet)

    SciTech Connect

    Not Available

    2009-04-01

    Energy Efficiency/Renewable Energy Fact Sheets, No. 1. Series to include practical, useful info to help people change their behavior around energy usage and "greenness". Greensburg is hanging its future on sustainable development; these fact sheet sheets should help citizens understand what they can do to be a part of that focus. Fact Sheets cover: saving energy and water, using renewable energy (particular interest in small wind), driving "green", general sustainability, living green.

  6. From Tragedy to Triumph: Rebuilding Greensburg, Kansas To Be a 100% Renewable Energy City; Preprint

    SciTech Connect

    Pless, S.; Billman, L.; Wallach, D.

    2010-08-01

    On May 4, 2007, Greensburg, Kansas, was hit by a 1.7-mile wide tornado with 200 mph-plus wind speeds. This tornado destroyed or severely damaged 90% of Greensburg?s structures. We discuss the progress made in rebuilding Greensburg, with a focus on the built environment and on meeting Greensburg?s goal of 100% renewable energy, 100% of the time. We also discuss key disaster recovery efforts that enabled Greensburg to reach this goal. Key strategies included a Sustainable Comprehensive Master Plan, an ordinance resolving that city-owned buildings achieve LEED Platinum and 42% energy savings, a strong focus on rebuilding 'right' with an integrated design process, attracting significant and sustained technical experts and national media attention, and linking renewable and energy efficiency technologies to business development. After three years, more than half the homes that have been rebuilt are rated at an average of 40% energy savings. All significant commercial buildings, including the school, hospital, banks, courthouse, and retail buildings, have been rebuilt to LEED Gold and Platinum standards and exceed 40% savings, with many exceeding 50% savings. Greensburg recently constructed a 12.5-MW community wind farm to provide all the remaining energy needed for its energy-efficient buildings and homes.

  7. Canada in the 21st Century - Triumph or Tragedy? The Front Line.

    ERIC Educational Resources Information Center

    Kilgour, David

    1996-01-01

    Argues that new patterns of trade and production combined with an emphasis on a knowledge-based economy/society make it imperative that Canada upgrade its educational system. Specifically notes that several growing and dominant industries (microelectronics, biotechnology, telecommunications) require a high-tech skilled labor force. (MJP)

  8. In Their Own Words: Researchers' Stories of Challenges and Triumphs in Data Management and Sharing

    NASA Astrophysics Data System (ADS)

    Rebich Hespanha, S.; Menz, S. M.

    2013-12-01

    As data-intensive computational analysis has become more pervasive in the Earth and environmental sciences, the need for adopting new ways to organize, manage, and preserve data has become increasingly apparent. As more and more data are collected, the benefits (or potential benefits) of sharing and re-using these data become ever more obvious. Technically-inclined disciplinary scientists, informaticians, and advocates of open science have already begun working together to develop tools and best practices that help to pave the way for a new era in data management and sharing. In spite of these innovative (and mostly technical) advances, researchers who wish to effectively manage and re-use data, or who are obligated by funding requirements to do so, still face many challenges. Here we report on the DataONE Data Stories project, which is focused on collecting researchers' stories about conflicts and successes that they have encountered when managing data and making efforts to share or re-use data. We highlight the types of events and situations that commonly lead to conflict or obstacles for the researchers we have interviewed. We emphasize in particular those difficulties for which no adequate technical solutions currently exist, or for which technical solutions do not seem to be appropriate, in the hope that our analysis of these stories will stimulate dialogue about the kinds of technical, social, and cultural solutions most needed to accelerate growth in better data management and sharing. Finally, we provide examples of how we have incorporated some of the researchers' data stories into the DataONE data management curriculum in order to support higher levels of engagement with the material and foster discussion among researchers about the complexities of the challenges they will likely encounter as they explore the world of data stewardship and reuse.

  9. The triumph of pragmatism: Nigeria's role in the Organization of the Petroleum Exporting Countries

    SciTech Connect

    Dimah, A.

    1988-01-01

    Formed in 1960, the Organization of the Petroleum Exporting Countries (OPEC) became a key participant in the international oil industry after the so-called oil shock in the early 1970s. OPEC's power in world trade increased tremendously during the 1970s and, as oil prices skyrocketed, literature on OPEC proliferated. Although OPEC's demise has often been predicted since its creation; it has, however, endured. Thus study examines OPEC from distinct vantage points: those of regime theory, oligopoly models, and cartel theory. The aim is to gain insight into the activities of the organization as a whole and in terms of the behavior of one of its members, the Government of Nigeria. The objective is to ascertain which of these theories, or aspects of the theories, best describes OPEC's activities and Nigeria's actions as a member. The review of OPEC and Nigeria's role in its demonstrates that OPEC is difficult to classify. It is more than anything, a fluid coalition of Third World countries seeking to improve their national economies by ensuring better prices for crude oil, their chief export product; and helping other Third World countries focus global awareness on the chronic political and economic inequities in the international system. Therefore, OPEC and Nigeria's role is best explained by coalition theory.

  10. Black History Month: Serious Truth Telling or a Triumph in Tokenism?

    ERIC Educational Resources Information Center

    Franklin, John Hope; Horne, Gerald; Cruse, Harold W.; Ballard, Allen R.; Mitchell, Reavis L., Jr.

    1998-01-01

    Discusses whether Black History Month effectively introduces the world to the achievements of American blacks or is primarily a marketing device for selling books and making African Americans feel good. Responses are provided from several African-American history professors. (GR)

  11. A Triumph of Hope over Reason? Aid Accords and Education Policy in Kenya

    ERIC Educational Resources Information Center

    Colclough, Christopher; Webb, Andrew

    2012-01-01

    Despite a long history of post-independence aid to education, Kenya's relationships with overseas donors have, until recently, been markedly fractious. Donors' concerns about transparency and corruption, in the context of a political regime which became increasingly authoritarian, led to sharp reductions in aid to Kenyan education during the…

  12. Benefits of voluntary industry standards: The triumph of experience over regulation

    SciTech Connect

    O`Leary, J.T.

    1996-12-31

    Voluntary international standards for mining machinery may gradually replace many national regulations. The days of establishing voluntary standards nation by nation, inhibiting the important flow of international trade, could be numbered. This does not mean that nations will cease domestic regulatory activities within their boundaries, but rulemaking will pay considerable attention to voluntary international standards and will likely strive for compatibility with voluntary international standards. International standards setting bodies are developing standards for machine safety. When these standards are complete and adopted, some nations will require machinery to comport with them. International commerce in products that do not conform to these voluntary international standards may be discouraged.

  13. The Triumph of Religious Education for Citizenship in English Schools, 1935-1949

    ERIC Educational Resources Information Center

    Freathy, Rob

    2008-01-01

    The failure of the Association for Education in Citizenship to gain official support for the secular and pedagogically progressive forms of education for citizenship that its founder members endorsed has previously been explained by the political impotence of the association's founder members and the professional conservatism of the educational…

  14. Triumph or Triage? The World Food Problem in Geographical Perspective. Resource Paper No. 75-3.

    ERIC Educational Resources Information Center

    Knight, C. Gregory; Wilcox, R. Paul

    Emphasizing a problem-solving perspective, the document investigates the world food scene. Simply defined, the world food problem is the apparent inability of the world's people to feed themselves adequately and consistently. Intended for use by college level geography instructors as they develop courses on human uses of the environment, the…

  15. Triumph and controversy. Pasteur's preventive treatment of rabies as reported in JAMA.

    PubMed

    Hoenig, L J

    1986-04-01

    Louis Pasteur's vaccine against rabies, introduced 100 years ago, was greeted by the American medical community with a mixture of praise and skepticism. These sentiments as well as details of Pasteur's landmark discoveries appeared in late-19th-century articles in The Journal of the American Medical Association.

  16. Challenges, Frustrations and Triumphs of Remixing an Open Source Game Engine for Educational Purposes

    ERIC Educational Resources Information Center

    Stowell, Timothy; Shelton, Brett E.

    2008-01-01

    The use, reuse, and remixing of commercial games has influenced the field of educational gaming. Part of this influence is felt though a number of popular game engines whose code has been released for the creation of games by other groups. This paper follows one group's progress of using the open-source and highly successful commercial game engine…

  17. Pioglitazone (Actos) and bladder cancer: Legal system triumphs over the evidence.

    PubMed

    Davidson, Mayer B

    2016-08-01

    In preclinical studies, pioglitazone was associated with bladder cancer in male rats (but not in female rats, mice dogs or monkeys). Because of this association, the Federal Drug Administration requested a large 10year epidemiological study to evaluate whether there was an association between bladder cancer and exposure to pioglitazone in patients. A 5-year interim report published in 2011 showed no significant association between ever vs never exposure to the drug but a significant association in patients exposed to pioglitazone for >2years. Importantly, the final 10year report did not confirm the 5year interim report finding no association between bladder cancer and pioglitazone, even after >4years of exposure to the drug. However, as would be expected, following the 5-year interim report, many epidemiological studies were carried out and civil litigation lawsuits began to be filed. Of the 23 epidemiological studies that have been published to date, 18 showed no association between bladder cancer and pioglitazone (5 with a combination of rosiglitazone and pioglitazone). Of the five that did show a significant association with pioglitazone, three could not be confirmed in the same population and in one of them there were significantly more risk factors for bladder cancer in the patients exposed to pioglitazone. In the fourth one, a significant association became non-significant when patients >79years were included. In the fifth one, detection bias was a major flaw. Currently, >11,000 legal cases have been filed, many of which claim emotional distress due to the fear of bladder cancer. To limit their legal costs, the pharmaceutical company has established a 2.4 billion dollar settlement pool. So much for evidence-based medicine.

  18. The Triumph and Tragedies of Japanese Women in America: A View across Four Generations

    ERIC Educational Resources Information Center

    Sakamoto, Taylor

    2007-01-01

    The author lives in a place filled with opportunities for girls like her. She is fortunate to attend school and enjoy activities like other young ladies. Her third- and fourth-generation parents encouraged her to attend Japanese Cultural School to learn about her heritage and to be proud of being Japanese-American. Her life has been filled with…

  19. Experiences of Secondary Hispanic Immigrant Students: Their Stories of Challenge and Triumph

    ERIC Educational Resources Information Center

    McCartney, Cynthia; Harris, Sandra; Farrow, Vicky

    2012-01-01

    Secondary Hispanic immigrant students have many struggles and barriers to overcome. This qualitative study investigated the experiences of 10 secondary immigrant Hispanic students, all non-English speakers, as they lived and attended high school in the United States. Narrative techniques were used to explore the challenges they faced in culture,…

  20. The Promotion and Marketing of OxyContin: Commercial Triumph, Public Health Tragedy

    PubMed Central

    2009-01-01

    I focus on issues surrounding the promotion and marketing of controlled drugs and their regulatory oversight. Compared with noncontrolled drugs, controlled drugs, with their potential for abuse and diversion, pose different public health risks when they are overpromoted and highly prescribed. An in-depth analysis of the promotion and marketing of OxyContin illustrates some of the associated issues. Modifications of the promotion and marketing of controlled drugs by the pharmaceutical industry and an enhanced capacity of the Food and Drug Administration to regulate and monitor such promotion can have a positive impact on the public health. PMID:18799767

  1. Using Neural Progenitor Cells in High-Throughput Screens for Developmental Neurotoxicants: Triumphs and Tragedies

    EPA Science Inventory

    Current protocols for developmental neurotoxicity testing are insufficient to test thousands of commercial chemicals. Thus, development of highthroughput screens (HTS) to detect and prioritize chemicals that may cause developmental neurotoxicity is needed to improve protection of...

  2. Russian war surgery in 1812: 200 years since Russia's war triumph.

    PubMed

    Boсkeria, Leo A; Glyantsev, Sergey P; Kolesnikov, Yan G

    2012-01-01

    Specific wounds inflicted on soldiers and officers of the Russian Army by French firearms and cold weapon and wound treatment by Russian surgeons during 1812 Napoleon's invasion (better known in Russia as the Patriotic War of 1812) are discussed. An inference is made that the then surgical treatment was not only administered at a high level but was also versatile and efficient and thus could make a certain contribution to the victory of the Russian arms.

  3. The Triumph of the Market and the Decline of Liberal Education: Implications for Civic Life

    ERIC Educational Resources Information Center

    Roosevelt, Grace

    2006-01-01

    The purpose of this article is to argue that the growing commercialization of education and the simultaneous decline of what has traditionally been called "liberal education" will limit the range of political discourse and thus have negative effects on civic life. In a context driven mainly by the profit motive, not-for-profit educational…

  4. Post Civil War African American History: Brief Periods of Triumph, and Then Despair.

    PubMed

    Graff, Gilda

    2016-01-01

    During Reconstruction, which is often called the most progressive period in American history, African Americans made great strides. By 1868 African American men constituted a majority of registered voters in South Carolina and Mississippi, and by 1870 eighty-five percent of Mississippi's black jurors could read and write. However, Reconstruction was followed by approximately one hundred years of Jim Crow laws, lynching, disenfranchisement, sharecropping, unequal educational resources, terrorism, racial caricatures, and convict leasing. The Civil Rights Revolution finally ended that period of despair, but the era of mass incarceration can be understood as a reaction to the Civil Rights Movement. This article attempts to understand the persistence of racism in the United States from slavery's end until the present.

  5. The Triumph of the Industrial-Consumer Paradigm and English as the Global Language

    ERIC Educational Resources Information Center

    Spring, Joel

    2007-01-01

    This article considers the role of English as the global language within the industrial-consumer paradigm. In the 21st century, the English language plays a different function in the global economy than it did during the 19th century when it was used as an instrument of cultural imperialism. Today, English serves as a vehicle for participation in…

  6. A Place on the Team: The Triumph and Tragedy of Title IX

    ERIC Educational Resources Information Center

    Suggs, Welch

    2006-01-01

    "A Place on the Team" is the inside story of how Title IX revolutionized American sports. The federal law guaranteeing women's rights in education, Title IX opened gymnasiums and playing fields to millions of young women previously locked out. Journalist Welch Suggs chronicles both the law's successes and failures-the exciting opportunities for…

  7. Fighting the "Damnable Triumph" of Feminism: Battles between Teachers' Unions in Interwar Britain

    ERIC Educational Resources Information Center

    Wilson, Dolly Smith

    2007-01-01

    The interwar decades saw a bitter recruiting war between the NUT (National Union of Teachers), the National Union of Women Teachers (NUWT), and the National Association of Schoolmasters (NAS), which like the NUWT broke away from the NUT in the early 1920s. The NAS opposed the NUT's official policy shift to support equal pay for male and female…

  8. Flat-panel electronic displays: a triumph of physics, chemistry and engineering

    PubMed Central

    Hilsum, Cyril

    2010-01-01

    This paper describes the history and science behind the development of modern flat-panel displays, and assesses future trends. Electronic displays are an important feature of modern life. For many years the cathode ray tube, an engineering marvel, was universal, but its shape was cumbersome and its operating voltage too high. The need for a flat-panel display, working at a low voltage, became imperative, and much research has been applied to this need. Any versatile flat-panel display will exploit an electro-optical effect, a transparent conductor and an addressing system to deliver data locally. The first need is to convert an electrical signal into a visible change. Two methods are available, the first giving emission of light, the second modulating ambient illumination. The most useful light-emitting media are semiconductors, historically exploiting III–V or II–VI compounds, but more recently organic or polymer semiconductors. Another possible effect uses gas plasma discharges. The modulating, or subtractive, effects that have been studied include liquid crystals, electrophoresis, electrowetting and electrochromism. A transparent conductor makes it possible to apply a voltage to an extended area while observing the results. The design is a compromise, since the free electrons that carry current also absorb light. The first materials used were metals, but some semiconductors, when heavily doped, give a better balance, with high transmission for a low resistance. Delivering data unambiguously to a million or so picture elements across the display area is no easy task. The preferred solution is an amorphous silicon thin-film transistor deposited at each cross-point in an X–Y matrix. Success in these endeavours has led to many applications for flat-panel displays, including television, flexible displays, electronic paper, electronic books and advertising signs. PMID:20123746

  9. Post Civil War African American History: Brief Periods of Triumph, and Then Despair.

    PubMed

    Graff, Gilda

    2016-01-01

    During Reconstruction, which is often called the most progressive period in American history, African Americans made great strides. By 1868 African American men constituted a majority of registered voters in South Carolina and Mississippi, and by 1870 eighty-five percent of Mississippi's black jurors could read and write. However, Reconstruction was followed by approximately one hundred years of Jim Crow laws, lynching, disenfranchisement, sharecropping, unequal educational resources, terrorism, racial caricatures, and convict leasing. The Civil Rights Revolution finally ended that period of despair, but the era of mass incarceration can be understood as a reaction to the Civil Rights Movement. This article attempts to understand the persistence of racism in the United States from slavery's end until the present. PMID:27108470

  10. Social Determinants and Disparities in Health: Their Crucifixion, Resurrection, and Ultimate Triumph(?) in Health Policy.

    PubMed

    House, James S

    2016-08-01

    David Mechanic has been a principal founder of modern sociological and social science approaches to health, especially in relation to health policy. These approaches have since the 1950s and 1960s resurrected ideas that had currency in the mid-nineteenth century but seemed crucified, dead, and buried by the rise of modern biomedicine from the mid-nineteenth century through the mid-twentieth century. Problems and lacunae in purely biomedical approaches to health in the later twentieth century, along with developments of new biopsychosocial approaches to health, have spawned a return toward ideas of Rudolf Virchow and mid-nineteenth-century social medicine that social determinants and disparities are major drivers of population health. Since individual health and population health constitute the major determinants of health care utilization and expenditures, social determinants and disparities in health are arguably the foundation of a new "demand-side" health policy that can resolve America's paradoxical health policy crisis of spending increasingly more than any nation on health care and insurance yet achieving increasingly worsening health outcomes relative to virtually all developed countries and some developing ones as well, something that current "supply-side" health policy, including Obamacare, cannot do, important as it is for expanding access to health insurance and care. PMID:27127266

  11. I Thought You Were One of Us! Triumphs and Crisis When Teaching Your Own

    ERIC Educational Resources Information Center

    Heer, Kal

    2015-01-01

    Authoritative knowledge produced by white acacemics has forged much of the cannon in educational research. Recently, scholars of color, have been asserting their unique positionalities to conduct research and teach among their own communities. As a result they have provided a challenge to normative privilege whiteness in education. Claims of…

  12. A Triumph For MERIS: Monitoring Of Blooms And Vegetation Using The Global MERIS MCI Data Set

    NASA Astrophysics Data System (ADS)

    Gower, Jim; Young, Erika; King, Stephanie

    2013-12-01

    The Maximum Chlorophyll Index (MCI) has successfully demonstrated a new way to monitor floating and near-surface vegetation and intense surface plankton blooms in coastal and ocean waters. MERIS MCI shows some blooms in which high radiance at 709 nm is the dominant feature of their optical spectrum. Such blooms would not be detectable without a band at this wavelength. The 10-year dataset is unique to MERIS in that the 709 nm band is not included in other wide-swath water-colour imagers such as MODIS, SeaWiFS or VIIRS. We have used the MERIS data to show patterns of pelagic Sargassum never before seen from space, an increasing trend of Antarctic “superblooms,” and details of the global distribution of Trichodesmium and other blooms. In this paper we show examples from the full global MCI dataset compiled during a joint ESA (GPOD) and Canadian Space Agency project.

  13. The Triumph of Hope over Experience in the Search for "What Works": A Response to Slavin

    ERIC Educational Resources Information Center

    Olson, David R.

    2004-01-01

    Slavin's call for evidence-based research on the effectiveness of treatments is criticized for its unreflective concept of a "treatment." It is argued that treatments cannot be defined objectively but only relative to the beliefs, goals, and intentions of those supposedly affected by the treatments. An alternative approach to the study of…

  14. Triumphs Show: Getting Year 10 beyond Trivial Judgements of "Bias": Towards Victory in "That" Battle …

    ERIC Educational Resources Information Center

    Hinks, Thomas

    2014-01-01

    Back in 1993 and 2000, Lang and LeCocq, respectively, in their reactions against reductive and de-contextualised forms of "source work", pointed out that all sources do hold value in some way, even, and often especially, in those aspects that might be deemed "biased". The author's Year 10s' difficulty in shaking off a…

  15. Program Converts VAX Floating-Point Data To UNIX

    NASA Technical Reports Server (NTRS)

    Alves, Marcos; Chapman, Bruce; Chu, Eugene

    1996-01-01

    VAX Floating Point to Host Floating Point Conversion (VAXFC) software converts non-ASCII files to unformatted floating-point representation of UNIX machine. This is done by reading bytes bit by bit, converting them to floating-point numbers, then writing results to another file. Useful when data files created by VAX computer must be used on other machines. Written in C language.

  16. Even during Hiring Freezes, Many Colleges Stick with Sustainability Plans

    ERIC Educational Resources Information Center

    Carlson, Scott

    2009-01-01

    Michael J. O'Connor, the physical-plant director at Appalachian State University, is watching his staff shrink bit by bit. When people leave, he's not rehiring. There is one exception to his staffing plan, however. Despite the economic duress, he is conducting a national search for a sustainability director. The university has ambitious…

  17. Geography via the Overhead Projector: Do It This Way, 7.

    ERIC Educational Resources Information Center

    Best, Thomas D.

    This booklet is designed to assist teachers in their use of overhead projectors when teaching geography. With the overhead technique, relationships among patterns can be suggested bit by bit on inexpensive, easily prepared overlays that are projected to sizes appropriate for a particular instructional situation. A general discussion of the…

  18. "A triumph of brains over brute": women and science at the Horticultural College, Swanley, 1890-1910.

    PubMed

    Opitz, Donald L

    2013-03-01

    The founding of Britain's first horticultural college in 1889 advanced a scientific and coeducational response to three troubling national concerns: a major agricultural depression; the economic distress of single, unemployed women; and imperatives to develop the colonies. Buoyed by the technical instruction and women's movements, the Horticultural College and Produce Company, Limited, at Swanley, Kent, crystallized a transformation in the horticultural profession in which new science-based, formalized study threatened an earlier emphasis on practical apprenticeship training, with the effect of opening male-dominated trades to women practitioners. By 1903, the college closed its doors to male students, and new pathways were forged for women students interested in pursuing further scientific study. Resistance to the Horticultural College's model of science-based women's horticultural education positioned science and women as contested subjects throughout this period of horticulture's expansion in the academy.

  19. Bridge of Signs: Can Sign Language Empower Non-Deaf Children to Triumph over Their Communication Disabilities?

    ERIC Educational Resources Information Center

    Toth, Anne

    2009-01-01

    This pilot research project examined the use of sign language as a communication bridge for non-Deaf children between the ages of 0-6 years who had been diagnosed with, or whose communication difficulties suggested, the presence of such disorders as Autism, Down Syndrome, Fetal Alcohol Spectrum Disorder (FASD), and/or learning disabilities.…

  20. Inspiration in the harness of daily labor. Darwin, botany, and the triumph of evolution, 1859-1868.

    PubMed

    Bellon, Richard

    2011-09-01

    Charles Darwin hoped that a large body of working naturalists would embrace evolution after the Origin of Species appeared in late 1859. He was disappointed. His evolutionary ideas at first made painfully little progress in the scientific community. But by 1863 the tide had turned dramatically, and within five years evolution became scientific orthodoxy in Britain. The Origin's reception followed this peculiar trajectory because Darwin had not initially tied its theory to productive original scientific investigation, which left him vulnerable to charges of reckless speculation. The debate changed with his successful application of evolution to original problems, most notably orchid fertilization, the subject of a well-received book in 1862. Most of Darwin's colleagues found the argument of the Origin convincing when they realized that it functioned productively in the day-to-day work of science-and not before. The conceptual force of the Origin, however outwardly persuasive, acquired full scientific legitimacy only when placed "in the harness of daily labour". PMID:22073768

  1. Trials, tribulations, and triumphs of a pilot initiative to optimize the management of wounds complicated by diabetes within the home.

    PubMed

    Hodgins, Marilyn J; Logan, Susan M; Price, Karla; Thompson, Carol

    2014-01-01

    To support home health care nurses in their efforts to optimize the management of patients with wounds complicated by diabetes, an initiative was introduced that incorporated a standardized assessment tool, electronic data entry, and the provision of written treatment recommendations with supporting rationale prepared by nurses with expertise in diabetes and wound care. A pilot study was conducted that provided preliminary evidence of the feasibility of this initiative as well as its potential effect on outcomes for patients, nurses, and the home care program.

  2. The trials, tribulations, and triumphs of black faculty in the math and science pipeline: A life history approach

    NASA Astrophysics Data System (ADS)

    Williams, Lisa D.

    2000-12-01

    This study explores the career progression and life history of black mathematicians and scientists who teach on university faculties in the United States. It investigates the following questions: Why are there so few black mathematicians and scientists in colleges and universities in the United States? What is the experience of black students who express an interest in science and math? What barriers do black scientists and mathematicians face as they move through school towards their career in higher education? What factors facilitate their success? The current literature shows that there are few women and minorities teaching or working in math and science compared to white men, although reasons for this underrepresentation are still not well understood. I explored this phenomenon by conducting two sets of in-depth interviews with twelve black faculty, six women, six men, from both historically black and predominantly white higher educational institutions in the United States. My interviews were based upon a life history approach that identified the participants' perceptions of the barriers and obstacles, as well as the supports and facilitators encountered in their schooling and career progression. The findings from the study show the importance of a strong family, community, and teacher support for the participants throughout their schooling. Support systems continued to be important in their faculty positions. These support systems include extended family members, teachers, community members, supervisors, and classmates, who serve as role models and mentors. The life study interviews provide striking evidence of the discrimination, isolation, and harassment due to race and gender experienced by black male and female mathematicians and scientists. The racial discrimination and the compounding effect of racism and sexism play out differently for the male and female participants in this study. This study suggests directions for future research on the experiences of young black students who are currently in the math and science educational pipeline. It also offers recommendations for ways in which parents, teachers, administrators, faculty, advisors, and government officials can enhance the educational experiences of black students who express interest and have skills in math and science.

  3. News from Front (of the Solar System): the problem with Mercury, the Vulcan hypothesis, and General Relativity's first astronomical triumph

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2016-01-01

    The discovery of the outer planet Neptune in 1846, based on the calculated position published by Urbain Jean Joseph Le Verrier, has been hailed as the "zenith of Newtonian mechanics." An attempt by Le Verrier to further extend the dominion of Newton's gravitational theory to the innermost known planet of the Solar System, Mercury, seemingly came to grief with the discovery of a small unexplained discrepancy in the precession of the perihelion of Mercury, whose value was later calculated as 43".0 per century. Le Verrier proposed that it could be explained on the basis of Newtonian theory by assuming the existence of an intra-mercurial planet ("Vulcan") or ring of debris. Efforts to confirm this hypothesis, culminating in high drama on the plains of the western United States at the great North American solar eclipse of July 1878, proved futile; by 1908, W. W. Campbell and C.D. Perrine of Lick Observatory, who had carried out exhaustive photographic searches at three eclipses (1901, 1905, and 1908) could declare that Vulcan did not exist. The theoretical problem it was invoked to explain remained until November 1915, when Albert Einstein used the recently discovered generally covariant gravitational equations to put the problem to rest. "Perihelion motions explained quantitatively … you will be astonished," he wrote to his friend Michael Besso.

  4. Love is the triumph of the imagination: Daydreams about significant others are associated with increased happiness, love and connection.

    PubMed

    Poerio, Giulia L; Totterdell, Peter; Emerson, Lisa-Marie; Miles, Eleanor

    2015-05-01

    Social relationships and interactions contribute to daily emotional well-being. The emotional benefits that come from engaging with others are known to arise from real events, but do they also come from the imagination during daydreaming activity? Using experience sampling methodology with 101 participants, we obtained 371 reports of naturally occurring daydreams with social and non-social content and self-reported feelings before and after daydreaming. Social, but not non-social, daydreams were associated with increased happiness, love and connection and this effect was not solely attributable to the emotional content of the daydreams. These effects were only present when participants were lacking in these feelings before daydreaming and when the daydream involved imagining others with whom the daydreamer had a high quality relationship. Findings are consistent with the idea that social daydreams may function to regulate emotion: imagining close others may serve the current emotional needs of daydreamers by increasing positive feelings towards themselves and others.

  5. John Collins Warren and his act of conscience: a brief narrative of the trial and triumph of a great surgeon.

    PubMed Central

    Moore, F D

    1999-01-01

    On examination of the correspondence among the principals involved, as well as the original patent application being prepared by Morton, it has become possible to reconstruct some of the remarkable details attending the first use of ether anesthesia at the Massachusetts General Hos pital in the autumn of 1846. At the time that Warren invited Morton to demonstrate the use of his "ethereal vapor" for anesthesia in a minor operation on Oct. 16, 1846, the exact chemical composition of the agent used was being held secret by Morton; Warren was clearly disturbed by this unethical use of a secret "nostrum." When the time arrived 3 weeks later for its possible use for a serious "capital" operation, Warren employed a simple stratagem of public confrontation to discover from Morton the true nature of the substance to be used. On being informed that it was pure unadulterated sulfuric ether, not some mysterious new discovery labeled "Letheon," Warren gave approval for its first use in a "capital" operation (low thigh amputation) on Nov. 7, 1846. Despite this revelation to the immediate participants, a veil of secrecy continued to surround the substance for many months, an anomalous situation evidently traceable to Morton's desire for personal reward from the discovery. It was this matter of secrecy, rather than priority for its discovery, that surrounded the early use of ether anesthesia with controversy and recrimination both in this country and abroad. Images Figure 2. PMID:10024099

  6. Sunday Sport Comes to Pennsylvania: Professional Baseball and Football Triumph over the Commonwealth's Archaic Blue Laws, 1919-1933.

    ERIC Educational Resources Information Center

    Jable, J. Thomas

    Following World War I, many Americans plunged into sport, and found the Sabbath a convenient and popular day for engaging in sporting events, especially since Sunday activities had become commonplace during the War and acceptable in many areas. However, when Pennsylvanians turned to sport on the Sabbath, they were confronted by the state's archaic…

  7. Trouble and Triumph: German Life-Turkish Tradition in Renan Demirkan's "Schwarzer Tee mit drei Stuck Zucker"

    ERIC Educational Resources Information Center

    Ebert, Reika

    2004-01-01

    This paper explores Demirkan's narrative strategies in "Schwarzer Tee mit drei Stuck Zucker" to negotiate issues of a life between two cultures and traditions. Based on Bhabha's insights that mainstream culture needs intellectual and artistic infusion from the margins of a society in order to remain vital; and that cultural production itself is a…

  8. The Tragedy and Triumph of Minamata: A Paradigm for Understanding Ecological, Human-Environment and Culture-Technology Interactions.

    ERIC Educational Resources Information Center

    Allchin, Douglas

    1999-01-01

    Contends that the example of mercury poisoning in Minamata, Japan can be used as a paradigm for teaching ecology and science-and-society issues. Discusses the history and science of the pollution and poisoning, and considers the social and cultural consequences of the incident, some aspects of causation and responsibility, and some aspects of…

  9. Images of Struggle and Triumph: Using Picture Books to Teach about the Civil Rights Movement in the Secondary Classroom

    ERIC Educational Resources Information Center

    Wilkins, Karen H.; Sheffield, Caroline C.; Ford, Martha B.; Cruz, Barbara C.

    2008-01-01

    This article describes four picture books ("Mississippi Morning" written by Ruth Vander Zee, "Dad, Jackie, and Me" written by Myron Uhlberg, "Freedom on the Menu" written by Carole Boston Weatherford, and "A Sweet Smell of Roses" written by Angela Johnson) that provide a concise (yet nuanced) chronicle of the civil rights movement--from the Jim…

  10. Inspiration in the harness of daily labor. Darwin, botany, and the triumph of evolution, 1859-1868.

    PubMed

    Bellon, Richard

    2011-09-01

    Charles Darwin hoped that a large body of working naturalists would embrace evolution after the Origin of Species appeared in late 1859. He was disappointed. His evolutionary ideas at first made painfully little progress in the scientific community. But by 1863 the tide had turned dramatically, and within five years evolution became scientific orthodoxy in Britain. The Origin's reception followed this peculiar trajectory because Darwin had not initially tied its theory to productive original scientific investigation, which left him vulnerable to charges of reckless speculation. The debate changed with his successful application of evolution to original problems, most notably orchid fertilization, the subject of a well-received book in 1862. Most of Darwin's colleagues found the argument of the Origin convincing when they realized that it functioned productively in the day-to-day work of science-and not before. The conceptual force of the Origin, however outwardly persuasive, acquired full scientific legitimacy only when placed "in the harness of daily labour".

  11. Satellite Communication Hardware Emulation System (SCHES)

    NASA Technical Reports Server (NTRS)

    Kaplan, Ted

    1993-01-01

    Satellite Communication Hardware Emulator System (SCHES) is a powerful simulator that emulates the hardware used in TDRSS links. SCHES is a true bit-by-bit simulator that models communications hardware accurately enough to be used as a verification mechanism for actual hardware tests on user spacecraft. As a credit to its modular design, SCHES is easily configurable to model any user satellite communication link, though some development may be required to tailor existing software to user specific hardware.

  12. Achieving the Holevo bound via a bisection decoding protocol

    NASA Astrophysics Data System (ADS)

    Rosati, Matteo; Giovannetti, Vittorio

    2016-06-01

    We present a new decoding protocol to realize transmission of classical information through a quantum channel at asymptotically maximum capacity, achieving the Holevo bound and thus the optimal communication rate. At variance with previous proposals, our scheme recovers the message bit by bit, making use of a series of "yes-no" measurements, organized in bisection fashion, thus determining which codeword was sent in log2 N steps, N being the number of codewords.

  13. Photoacoustic, Photothermal, and Diffusion-Wave Sciences in the Twenty-First Century: Triumphs of the Past Set the Trends for the Future

    NASA Astrophysics Data System (ADS)

    Mandelis, Andreas

    2012-11-01

    A handful of early breakthroughs in photoacoustic science and engineering since its modern-day (scientific) renaissance in the 1970s has defined directions in the development of the photoacoustic, photothermal, and diffusion-wave fields in the past 40 years that have shaped modern day developments and have led to an impressive range of vibrant and unique technologies in the third millennium (technological renaissance). A power-point presentation on the ICPPP-16 opening plenary talk focuses on the historical roots of what I perceive to be some of today's most successful and unique technologies, while readily acknowledging the impossibility to be all inclusive. It can be found under the url: http://cadift.mie.utoronto.ca/History_of_Photoacoustics-Photothermics.ppt. The thematic areas in question include historical reviews selected among the following topics: Piezoelectric photoacoustic microscopy (PAM) which, along with early gas-phase PA spectroscopic studies of biomaterials such as blood haemoglobin and progress in the physics of photon diffusion waves, has led to the modern-day explosion in biomedical photoacoustic imaging technologies with future trends for photoacoustic and ultrasound co-registered imagers; Thermoreflectance, piezoelectric, and gas-phase PA imaging of semiconductors which, along with developments in photocarrier diffusion wave physics, led to photocarrier radiometry, nanolayer diagnostics, carrierographic imaging of optoelectronic materials, and devices with industrial trends in solar cell inspection and control; Photoacoustic gas-phase and infrared radiometric probing and scanning imaging NDE which led to lock-in thermography and have spawned industrial and biomedical technologies; Thermal-wave interferometry and the quest for thermal coherence which led to thermal-wave cavities, the thermal-wave radar, and derivative depth profiling technologies, and, very recently, thermal coherence tomography. This review is meant to be a growing public record of work in progress, with new materials in the given thematic areas and other thematic areas being added as more information on the rich history of the field becomes available. Direct inputs to the author by the broader photoacoustic, photothermal, and diffusion-wave community are solicited and strongly encouraged to ensure that all landmark and seminal work that shaped the state of the science and art in the field receives fair and deserving exposure and the historical review becomes truly representative and comprehensive.

  14. The Market Triumph of Ecotourism: An Economic Investigation of the Private and Social Benefits of Competing Land Uses in the Peruvian Amazon

    PubMed Central

    Kirkby, Christopher A.; Giudice-Granados, Renzo; Day, Brett; Turner, Kerry; Velarde-Andrade, Luz Marina; Dueñas-Dueñas, Agusto; Lara-Rivas, Juan Carlos; Yu, Douglas W.

    2010-01-01

    Annual revenue flow to developing countries for ecotourism (or nature-based tourism) could be as large as US$ 210×1012, providing an enormous financial incentive against habitat loss and exploitation. However, is ecotourism the most privately and/or socially valuable use of rainforest land? The question is rarely answered because the relevant data, estimates of profits and fixed costs, are rarely available. We present a social cost-benefit analysis of land use in an ecotourism cluster in the Tambopata region of Amazonian Peru. The net present value of ecotourism-controlled land is given by the producer surplus (profits plus fixed costs of ecotourism lodges): US$ 1,158 ha−1, which is higher than all currently practiced alternatives, including unsustainable logging, ranching, and agriculture. To our knowledge, this is the first sector-wide study of profitability and producer surplus in a developing-country ecotourism sector and the first to compare against equivalent measures for a spectrum of alternative uses. We also find that ecotourism-controlled land sequesters between 5.3 to 8.7 million tons of above-ground carbon, which is equivalent to between 3000–5000 years of carbon emissions from the domestic component of air and surface travel between the gateway city of Cusco and the lodges, at 2005 emission rates. Ecotourism in Tambopata has successfully monetized the hedonic value of wild nature in Amazonian Peru, and justifies the maintenance of intact rainforest over all alternative uses on narrow economic grounds alone. PMID:20927377

  15. "Akeelah and the Bee": Inspirational Story of African-American Intellect and Triumph or Racist Rhetoric Served Up on Another Platter?

    ERIC Educational Resources Information Center

    Pimentel, Charise; Sawyer, Cathleen

    2011-01-01

    In this article, the authors look into the inspirational movie, "Akeelah and the Bee," a film about an African-American who goes against all odds to achieve success in grand proportions. Described as an "inspirational family film" and a "successful feel-good movie" (Turan, 2006), "Akeelah and the Bee" proved inspirational to many viewers, as it…

  16. 77 FR 2278 - Intent To Grant an Exclusive License for a U.S. Army Owned Invention to Triumph Actuation Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... June 12, 2007, ``Automatic Primer Feed Mechanism''; U.S. patent 7,246,549, issued July 24, 2007, ``Automatic Primer Feed Mechanism; U.S. patent 7,318,369, issued January 15, 2008, ``Out-of- Battery Lock for the Automatic Primer Feed Mechanism''; U.S. patent 7,845,264, issued December 7, 2010,...

  17. Multiple differences between patients who initiate fish oil supplementation post-myocardial infarction and those who do not: the TRIUMPH Study.

    PubMed

    Harris, William S; Kennedy, K F; Maddox, T M; Kutty, S; Spertus, J A

    2016-01-01

    The utility of fish oil supplements (FOS) in patients who survive an acute myocardial infarction (MI) remains controversial, with randomized trials showing less benefit than observational studies would suggest. The differences in the characteristics of MI patients who use FOS in routine clinical care are unknown but may help explain this discrepancy. We used data from a 24-site registry study in which extensive information was available on 4340 MI patients at admission and 1, 6, and 12 months postdischarge. After excluding those using FOS at admission (n = 651), those who died before the 1-month follow-up visit (n = 63), and those with missing data at 1 month (n = 1228), 2398 remained. Of them, 377 (16%) started FOS within 1 month of their MI. We analyzed 53 patient characteristics associated with FOS use. We observed differences (P < .001) in 20 demographic, socioeconomic, treatment, disease severity, and health status domains. The FOS users were more likely than nonusers to be white, married, financially secure, highly educated, and eating fish. They also had a higher ejection fraction at discharge, were more likely to have had in-hospital percutaneous coronary interventions, and were more likely to have participated in cardiac rehabilitation programs. The FOS users were less likely to have a history of diabetes, alcohol abuse, stroke, MI, and angina. In conclusion, post-MI patients who initiate FOS within 1 month of discharge in routine clinical practice differ substantially from those who do not. These differences are strongly associated with a better post-MI prognosis and may illuminate several sources of unmeasured confounding in observational studies.

  18. Tomorrow's Families: Triumph of the Individual or Sharing the Caring? (Les familles de demain: Triomphe de l'individu ou partage des soins a donner?).

    ERIC Educational Resources Information Center

    Theilheimer, Ish, Ed.

    1993-01-01

    This theme issue of the Canadian newsletter "Transitions" in both English and French explores the question of the future of families in a period of broken marriages, difficult times, and an obsession with individual success and materialism. "Families of the Future: New Ways to Do the Same Old Things," summarizes the findings of Canada's…

  19. The market triumph of ecotourism: an economic investigation of the private and social benefits of competing land uses in the Peruvian Amazon.

    PubMed

    Kirkby, Christopher A; Giudice-Granados, Renzo; Day, Brett; Turner, Kerry; Velarde-Andrade, Luz Marina; Dueñas-Dueñas, Agusto; Lara-Rivas, Juan Carlos; Yu, Douglas W

    2010-01-01

    Annual revenue flow to developing countries for ecotourism (or nature-based tourism) could be as large as US$ 210×10(12), providing an enormous financial incentive against habitat loss and exploitation. However, is ecotourism the most privately and/or socially valuable use of rainforest land? The question is rarely answered because the relevant data, estimates of profits and fixed costs, are rarely available. We present a social cost-benefit analysis of land use in an ecotourism cluster in the Tambopata region of Amazonian Peru. The net present value of ecotourism-controlled land is given by the producer surplus (profits plus fixed costs of ecotourism lodges): US$ 1,158 ha(-1), which is higher than all currently practiced alternatives, including unsustainable logging, ranching, and agriculture. To our knowledge, this is the first sector-wide study of profitability and producer surplus in a developing-country ecotourism sector and the first to compare against equivalent measures for a spectrum of alternative uses. We also find that ecotourism-controlled land sequesters between 5.3 to 8.7 million tons of above-ground carbon, which is equivalent to between 3000-5000 years of carbon emissions from the domestic component of air and surface travel between the gateway city of Cusco and the lodges, at 2005 emission rates. Ecotourism in Tambopata has successfully monetized the hedonic value of wild nature in Amazonian Peru, and justifies the maintenance of intact rainforest over all alternative uses on narrow economic grounds alone. PMID:20927377

  20. The market triumph of ecotourism: an economic investigation of the private and social benefits of competing land uses in the Peruvian Amazon.

    PubMed

    Kirkby, Christopher A; Giudice-Granados, Renzo; Day, Brett; Turner, Kerry; Velarde-Andrade, Luz Marina; Dueñas-Dueñas, Agusto; Lara-Rivas, Juan Carlos; Yu, Douglas W

    2010-09-29

    Annual revenue flow to developing countries for ecotourism (or nature-based tourism) could be as large as US$ 210×10(12), providing an enormous financial incentive against habitat loss and exploitation. However, is ecotourism the most privately and/or socially valuable use of rainforest land? The question is rarely answered because the relevant data, estimates of profits and fixed costs, are rarely available. We present a social cost-benefit analysis of land use in an ecotourism cluster in the Tambopata region of Amazonian Peru. The net present value of ecotourism-controlled land is given by the producer surplus (profits plus fixed costs of ecotourism lodges): US$ 1,158 ha(-1), which is higher than all currently practiced alternatives, including unsustainable logging, ranching, and agriculture. To our knowledge, this is the first sector-wide study of profitability and producer surplus in a developing-country ecotourism sector and the first to compare against equivalent measures for a spectrum of alternative uses. We also find that ecotourism-controlled land sequesters between 5.3 to 8.7 million tons of above-ground carbon, which is equivalent to between 3000-5000 years of carbon emissions from the domestic component of air and surface travel between the gateway city of Cusco and the lodges, at 2005 emission rates. Ecotourism in Tambopata has successfully monetized the hedonic value of wild nature in Amazonian Peru, and justifies the maintenance of intact rainforest over all alternative uses on narrow economic grounds alone.

  1. Satellite communications application to Pacific countries above Ku band

    NASA Astrophysics Data System (ADS)

    Iida, Takashi

    1992-08-01

    An application of satellite communications above the Ku band to the Pacific region is described, focusing on: (1) Lightsat system and (2) a high capacity satellite system. A small geostationary satellite system using Ku band for the Federated States of Micronesia is shown as an example. A concept of multi-gigabits/second high capacity communications system using two satellites in the Ka band is described. The onboard bit-by-bit processing is very useful in the low link margin environment due to rain attenuation. These topics were obtained by the Asia Pacific Telecommunications Study granted by NASA conducted by the University of Colorado at Boulder.

  2. Satellite communications application to Pacific countries above Ku band

    NASA Technical Reports Server (NTRS)

    Iida, Takashi

    1992-01-01

    An application of satellite communications above the Ku band to the Pacific region is described, focusing on: (1) Lightsat system and (2) a high capacity satellite system. A small geostationary satellite system using Ku band for the Federated States of Micronesia is shown as an example. A concept of multi-gigabits/second high capacity communications system using two satellites in the Ka band is described. The onboard bit-by-bit processing is very useful in the low link margin environment due to rain attenuation. These topics were obtained by the Asia Pacific Telecommunications Study granted by NASA conducted by the University of Colorado at Boulder.

  3. Method of parallel switching of optical channels

    SciTech Connect

    Kompanets, I N; Neevina, T A; Kompanets, S I

    2012-12-31

    The possibility of creating parallel-type switches for N Multiplication-Sign N optical waveguide channel communication is studied. A method based on bit-by-bit channel addressing is proposed and one of its possible implementations using the photorefractive effect in the waveguide material is considered. The method is modelled by the example of switching of 8 Multiplication-Sign 8 channels, controlled by reconfigurable matrix of light signals. (special issue devoted to the 90th anniversary of n.g. basov)

  4. A 12-bit, 1 MS/s SAR-ADC for a CZT-based multi-channel gamma-ray imager using a new digital calibration method

    NASA Astrophysics Data System (ADS)

    Liu, W.; Wei, T.; Yang, L.; Hu, Y.

    2016-03-01

    The successive approximation register-analog to digital converter (SAR-ADC) is widely used in the CdZnTe-based gamma-ray imager because of its outstanding characteristics of low power consumption, relatively high resolution, and small die size. This study proposes a digital bit-by-bit calibration method using an input ramp signal to further improve the conversion precision and power consumption of an SAR-ADC. The proposed method is based on the sub-radix-2 redundant architecture and the perturbation technique. The proposed calibration algorithm is simpler, more stable, and faster than traditional approaches. The prototype chip of the 12-bit, 1 MS/s radiation-hardened SAR-ADC has been designed and fabricated using the TSMC 0.35 μm 2P4M CMOS process. This SAR-ADC consumes 3 mW power and occupies a core area of 856× 802μm2. The digital bit-by-bit calibration algorithm is implemented via MATLAB for testing flexibility. The effective number of bits for this digitally calibrated SAR-ADC reaches 11.77 bits. The converter exhibits high conversion precision, low power consumption, and radiation-hardened design. Therefore, this SAR-ADC is suitable for multi-channel gamma-ray imager applications.

  5. Tragedy, transformation, and triumph: comparing the factors and forces that led to the adoption of the 1860 Adulteration Act in England and the 1906 Pure Food and Drug Act in the United States.

    PubMed

    London, Jillian

    2014-01-01

    The 1860 Adulteration Act in England and the 1906 Pure Food and Drug Act in the United States were two of the earliest pieces of legislation to provide generalized regulation of food and drugs on a national scale. While significant scholarly attention has been given to explaining the factors and forces that led to the passage of each Act independent of the other, few books or articles have directly compared the similar individuals and events that led to the adoption of both Acts. This paper attempts to fill that gap. Through a comparative examination, this paper reveals that four main components were key to the national pure food and drug movements in both countries: individuals who crusaded for national adulteration legislation; tragedies that shocked the public into calling for reform; press and publicity that was willing and able to bring the evils of adulteration to the forefront of the public mind; and a transformation of the social, political, and economic systems, which created atmospheres conducive to reform. This paper aims to shed new light on the 1860 Adulteration Act and the 1906 Pure Food and Drug Act--two acts that derive their importance not just from the effect that they directly had on the regulation of food and drugs but also as some of the earliest examples of western governments coming to recognize the need for national regulation to protect the public from harm and coming to embrace their changing role as spearheads of modern regulatory states. PMID:25163213

  6. A resolution celebrating the life and achievements of Lena Mary Calhoun Horne and honoring her for her triumphs against racial discrimination and her steadfast commitment to the civil rights of all people.

    THOMAS, 111th Congress

    Sen. Gillibrand, Kirsten E. [D-NY

    2010-05-14

    05/14/2010 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S3790-3792; text as passed Senate: CR S3791-3792; text of measure as introduced: CR S3786) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  7. Genetics and Mapping of Seedling Resistance to Ug99 Stem Rust in the Winter Wheat Cultivar Triumph 64 and Differentiation of SrTmp, SrCad, and Sr42

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Stem rust, caused by the fungus Puccinia graminis f. sp. tritici Eriks. & E. Henn. (Pgt), is an important disease of wheat that can be controlled by deploying effective stem rust resistance (Sr) genes. The emergence of virulent Pgt races in Africa, namely Ug99 and its variants, has stimulated the se...

  8. Triumphs Show: What Makes Art History? Year 7 Exploit the Resources of the Victoria and Albert Museum's Medieval Gallery to Create and Curate Their Own Answer

    ERIC Educational Resources Information Center

    Copsey, Sarah

    2014-01-01

    What do 14 Year 7 students, an art teacher, a history teacher and the Victoria and Albert Museum have in common? They are all part of the "Stronger Together" Museum Champion project run by The Langley Academy and the River & Rowing Museum and supported by Arts Council England, designed to engage students, teachers and museum staff…

  9. Computer program CORDET. [computerized simulation of digital phase-lock loop for Omega navigation receiver

    NASA Technical Reports Server (NTRS)

    Palkovic, R. A.

    1974-01-01

    A FORTRAN 4 computer program provides convenient simulation of an all-digital phase-lock loop (DPLL). The DPLL forms the heart of the Omega navigation receiver prototype. Through the DPLL, the phase of the 10.2 KHz Omega signal is estimated when the true signal phase is contaminated with noise. This investigation has provided a convenient means of evaluating loop performance in a variety of noise environments, and has proved to be a useful tool for evaluating design changes. The goals of the simulation are to: (1) analyze the circuit on a bit-by-bit level in order to evaluate the overall design; (2) see easily the effects of proposed design changes prior to actual breadboarding; and (3) determine the optimum integration time for the DPLL in an environment typical of general aviation conditions.

  10. ROM type holographic disk using computer generated hologram

    NASA Astrophysics Data System (ADS)

    Nishimoto, K.; Kubota, E.; Watanabe, D.; Yamaguchi, S.; Yamamoto, M.; Nakajima, M.; Kobayashi, T.

    2006-05-01

    ROM type holographic disk that can be made by the optical disk cutting method and has compatibility with the recordable holographic memory was studied. Computer generated hologram data was recorded on the master disk by bit-by-bit recording. Then, after making a stamper, a holographic disk was made by the injection molding. To this holographic disk, it was confirmed that the data reproduction of low bit error rate is possible. In order to enable data reproduction by using a continuously rotating disk, the recorded data was made in such a way that random phase is given to the reproduced data. It became possible to distribute data to the entire area of the hologram and it enabled the reproduction of all the data of the hologram by reproducing a part of the hologram. This made it possible to reproduce data with a continuously rotating disk. Furthermore, the simulation showed that multiplex recoding became possible by the aperture multiplexing.

  11. The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

    PubMed Central

    Williams, Evan G.; Auwerx, Johan

    2015-01-01

    Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit-by-bit, founded on the underlying hypothesis that genome-to-phenome relations are largely constructed from the additive effects of their molecular players. In contrast, the systems approach aims to examine large-scale interactions of many components simultaneously, on the premise that interactions in gene networks can be both linear and nonlinear. Both approaches are complementary, and they are becoming increasingly intertwined due to developments in gene editing tools, omics technologies, and population resources. Together, these strategies are beginning to drive the next era in complex trait research: paving the way to improve agriculture and towards more personalized medicine. PMID:26140590

  12. Security for a Smarter Planet

    NASA Astrophysics Data System (ADS)

    Nagaratnam, Nataraj

    Bit by bit, our planet is getting smarter. By this, we mean the systems that run, the way we live and work as a society. Three things have brought this about - the world is becoming instrumented, interconnected and intelligent. Given the planet is becoming instrumented and interconnected, this opens up more risks that need to be managed. Escalating security and privacy concerns along with a renewed focus on organizational oversight are driving governance, risk management and compliance (GRC) to the forefront of the business. Compliance regulations have increasingly played a larger role by attempting to establish processes and controls that mitigate the internal and external risks organizations have today. To effectively meet the requirements of GRC, companies must prove that they have strong and consistent controls over who has access to critical applications and data.

  13. Reconstruction of Genome Ancestry Blocks in Multiparental Populations

    PubMed Central

    Zheng, Chaozhi; Boer, Martin P.; van Eeuwijk, Fred A.

    2015-01-01

    We present a general hidden Markov model framework called reconstructing ancestry blocks bit by bit (RABBIT) for reconstructing genome ancestry blocks from single-nucleotide polymorphism (SNP) array data, a required step for quantitative trait locus (QTL) mapping. The framework can be applied to a wide range of mapping populations such as the Arabidopsis multiparent advanced generation intercross (MAGIC), the mouse Collaborative Cross (CC), and the diversity outcross (DO) for both autosomes and X chromosomes if they exist. The model underlying RABBIT accounts for the joint pattern of recombination breakpoints between two homologous chromosomes and missing data and allelic typing errors in the genotype data of both sampled individuals and founders. Studies on simulated data of the MAGIC and the CC and real data of the MAGIC, the DO, and the CC demonstrate that RABBIT is more robust and accurate in reconstructing recombination bin maps than some commonly used methods. PMID:26048018

  14. Asynchronous, all-optical signal processing based on the self-frequency shift of a gigahertz Raman soliton.

    PubMed

    Kato, Masao; Fujiura, Kazuo; Kurihara, Takashi

    2005-03-10

    Ultrafast asynchronous all-optical signal processing is experimentally demonstrated. It is based on the intensity-dependent, self-frequency shift of a gigahertz Raman soliton. We demonstrate error-free, asynchronous, all-optical, bit-by-bit, self-signal recognition and demultiplexing from contended optical packets without use of an optical buffer, control pulse, or bit-phase synchronization. Fourfold, contended, 9.95-Gbit/s optical packets are transmitted through a conventional repeater span of 80 km and simultaneously demultiplexed to multiwavelength 9.95-Gbit/s optical packets with 0.5-dB processing sensitivity. Furthermore, we successfully accomplish demultiplexing from overlapping signals in contended optical packets with better than 3-dB recognition sensitivity. We confirm the capability of realizing a 3x cascade operation from bit-error-rate measurements.

  15. More White Supremacy? "The Lord of the Rings" as Pro-American Imperialism

    ERIC Educational Resources Information Center

    Knaus, Christopher

    2005-01-01

    "The Lord of the Rings" continues Hollywood's recurrent theme of good triumphing over evil. The viewer is supposed to identify with the heroes, whiteness, and goodness, which of course triumphs over evil and blackness. Although the cast is made up almost entirely of White people, people also do not question this narrative of White supremacy. To…

  16. Stealing Innocence: Youth, Corporate Power, and the Politics of Culture.

    ERIC Educational Resources Information Center

    Giroux, Henry A.

    This book looks at the way corporate cultures is encroaching on children's lives. It explores three myths prevalent in society: (1) that the triumph of democracy is equal to the triumph of the market; (2) that children are unaffected by power and politics; and (3) that teaching and learning are no longer linked to improving the world. The book…

  17. What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of:“All that is necessary for the triumph of evil is that good men do nothing?”

    PubMed Central

    Triggle, Chris R; Triggle, David J

    2007-01-01

    Peer review is an essential component of the process that is universally applied prior to the acceptance of a manuscript, grant or other scholarly work. Most of us willingly accept the responsibilities that come with being a reviewer but how comfortable are we with the process? Peer review is open to abuse but how should it be policed and can it be improved? A bad peer review process can inadvertently ruin an individual’s career, but are there penalties for policing a reviewer who deliberately sabotages a manuscript or grant? Science has received an increasingly tainted name because of recent high profile cases of alleged scientific misconduct. Once considered the results of work stress or a temporary mental health problem, scientific misconduct is increasingly being reported and proved to be a repeat offence. How should scientific misconduct be handled—is it a criminal offence and subject to national or international law? Similarly plagiarism is an ever-increasing concern whether at the level of the student or a university president. Are the existing laws tough enough? These issues, with appropriate examples, are dealt with in this review. PMID:17583174

  18. Harriet Tubman and the Underground Railroad: A Drama Workshop for Junior High and High School Students.

    ERIC Educational Resources Information Center

    Tabone, Carmine; Albrecht, Robert

    2000-01-01

    Claims drama in the classroom offers teachers an opportunity to "bring to life" the challenges and triumphs of African Americans. Describes a drama workshop based on the story of Harriet Tubman and the Underground Railroad. (NH)

  19. Research Issues Underlying the Four-Lab Study: Integrated Disinfection Byproducts Mixtures Research

    EPA Science Inventory

    Chemical disinfection of drinking water is a major public health triumph of the 20th century, resulting in significant decreases in morbidity and mortality from waterborne diseases. Disinfection byproducts (DBPs) are chemicals formed by the reaction of oxidizing disinfectants wi...

  20. 3 CFR 8340 - Proclamation 8340 of January 15, 2009. Martin Luther King, Jr., Federal Holiday, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... who understood that love and compassion will always triumph over bitterness and hatred. As Americans, we believe it is self-evident that all men are created equal and that freedom is not a grant...

  1. Study report on laser storage and retrieval of image data

    NASA Technical Reports Server (NTRS)

    Becker, C. H.

    1976-01-01

    The theoretical foundation is presented for a system of real-time nonphotographic and nonmagnetic digital laser storage and retrieval of image data. The system utilizes diffraction-limited laser focusing upon thin metal films, melting elementary holes in the metal films in laser focus. The metal films are encapsulated in rotating flexible mylar discs which act as the permanent storage carries. Equal sized holes encompass two dimensional digital ensembles of information bits which are time-sequentially (bit by bit) stored and retrieved. The bits possess the smallest possible size, defined by the Rayleigh criterion of coherent physical optics. Space and time invariant reflective read-out of laser discs with a small laser, provides access to the stored digital information. By eliminating photographic and magnetic data processing, which characterize the previous state of the art, photographic grain, diffusion, and gamma-distortion do not exist. Similarly, magnetic domain structures, magnetic gaps, and magnetic read-out are absent with a digital laser disc system.

  2. Least Reliable Bits Coding (LRBC) for high data rate satellite communications

    NASA Technical Reports Server (NTRS)

    Vanderaar, Mark; Wagner, Paul; Budinger, James

    1992-01-01

    An analysis and discussion of a bandwidth efficient multi-level/multi-stage block coded modulation technique called Least Reliable Bits Coding (LRBC) is presented. LRBC uses simple multi-level component codes that provide increased error protection on increasingly unreliable modulated bits in order to maintain an overall high code rate that increases spectral efficiency. Further, soft-decision multi-stage decoding is used to make decisions on unprotected bits through corrections made on more protected bits. Using analytical expressions and tight performance bounds it is shown that LRBC can achieve increased spectral efficiency and maintain equivalent or better power efficiency compared to that of Binary Phase Shift Keying (BPSK). Bit error rates (BER) vs. channel bit energy with Additive White Gaussian Noise (AWGN) are given for a set of LRB Reed-Solomon (RS) encoded 8PSK modulation formats with an ensemble rate of 8/9. All formats exhibit a spectral efficiency of 2.67 = (log2(8))(8/9) information bps/Hz. Bit by bit coded and uncoded error probabilities with soft-decision information are determined. These are traded with with code rate to determine parameters that achieve good performance. The relative simplicity of Galois field algebra vs. the Viterbi algorithm and the availability of high speed commercial Very Large Scale Integration (VLSI) for block codes indicates that LRBC using block codes is a desirable method for high data rate implementations.

  3. Ultra-Fast Timing and the Application of High Energy Physics Technologies to Biomedical Imaging

    NASA Astrophysics Data System (ADS)

    Chen, Chin-Tu; Kao, Chien-Min; Xie, Quigguo; Frisch, Henry; Heinz, Mary; Sanders, Harold; Tang, Fukung; Anderson, John; Byrum, Karen; Drake, Gary; Heartly, Camden; Le Dû, Patrick; Royon, Christophe; Genat, Jean François; Va'Vra, Jerry

    2008-06-01

    We propose to apply the ultra fast Time Of Flight technique (TOF) developed for High Energy Physics (HEP) particle detectors to biomedical imaging. The similarity of the problem in the two fields as well as the remarkable opportunities in biomedical imaging to use technologies developed in HEP have the potential to make major advances in the medical world, in particular for Positron Emission Tomography (PET). We will describe and present some preliminary results of the development of a new complete read-out chain able to manage signals from various types of modern photo detectors (MCP, APD, SiPM). This innovative architecture is made of a fast front-end electronics ASIC with novel Digital Signal Processing (DSP) concepts able to reach the Pico-second timing resolution, a time-to-digital converter, a pipelined digital readout and an integrated trigger/filter with real-time data treatment and display. In parallel with the hardware development, we have begun a systematic program to simulate system characteristics from the initial particle interaction to the final digital data, including a bit-by-bit mapping of the front end/data acquisition system. The introduction of these techniques and tools, common in HEP, has the potential to make improvement to biomedical imaging systems.

  4. Maximum-Entropy Inference with a Programmable Annealer

    NASA Astrophysics Data System (ADS)

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A.

    2016-03-01

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition.

  5. Maximum-Entropy Inference with a Programmable Annealer.

    PubMed

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A

    2016-03-03

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition.

  6. Burst-mode optical label processor with ultralow power consumption.

    PubMed

    Ibrahim, Salah; Nakahara, Tatsushi; Ishikawa, Hiroshi; Takahashi, Ryo

    2016-04-01

    A novel label processor subsystem for 100-Gbps (25-Gbps × 4λs) burst-mode optical packets is developed, in which a highly energy-efficient method is pursued for extracting and interfacing the ultrafast packet-label to a CMOS-based processor where label recognition takes place. The method involves performing serial-to-parallel conversion for the label bits on a bit-by-bit basis by using an optoelectronic converter that is operated with a set of optical triggers generated in a burst-mode manner upon packet arrival. Here we present three key achievements that enabled a significant reduction in the total power consumption and latency of the whole subsystem; 1) based on a novel operation mechanism for providing amplification with bit-level selectivity, an optical trigger pulse generator, that consumes power for a very short duration upon packet arrival, is proposed and experimentally demonstrated, 2) the energy of optical triggers needed by the optoelectronic serial-to-parallel converter is reduced by utilizing a negative-polarity signal while employing an enhanced conversion scheme entitled the discharge-or-hold scheme, 3) the necessary optical trigger energy is further cut down by half by coupling the triggers through the chip's backside, whereas a novel lens-free packaging method is developed to enable a low-cost alignment process that works with simple visual observation. PMID:27136992

  7. A simulation analysis of phase processing circuitry in the Ohio University Omega receiver prototype

    NASA Technical Reports Server (NTRS)

    Palkovic, R. A.

    1975-01-01

    A FORTRAN IV simulation study of the all-digital phase-processing circuitry is described. A digital phase-lock loop (DPLL) forms the heart of the Omega navigation receiver prototype, and through the DPLL, the phase of the 10.2 KHz Omega signal was estimated when the true signal phase is contaminated with noise. The DPLL uses a frequency synthesizer as the reference oscillator. The synthesizer is composed of synchronous rate multipliers (SRM's) driven by a temperature-compensated crystal oscillator, and the use of the SRM's in this application introduces phase jitter which degrades system performance. Simulation of the frequency synthesizer discussed was to analyze the circuits on a bit-by-bit level in order to evaluate the overall design, to see easily the effects of proposed design changes prior to actual breadboarding, to determine the optimum integration time for the DPLL in an environment typical of general aviation conditions, and to quantify the phase error introduced by the SRM synthesizer and examine its effect on the system.

  8. LDFT-based watermarking resilient to local desynchronization attacks.

    PubMed

    Tian, Huawei; Zhao, Yao; Ni, Rongrong; Qin, Lunming; Li, Xuelong

    2013-12-01

    Up to now, a watermarking scheme that is robust against desynchronization attacks (DAs) is still a grand challenge. Most image watermarking resynchronization schemes in literature can survive individual global DAs (e.g., rotation, scaling, translation, and other affine transforms), but few are resilient to challenging cropping and local DAs. The main reason is that robust features for watermark synchronization are only globally invariable rather than locally invariable. In this paper, we present a blind image watermarking resynchronization scheme against local transform attacks. First, we propose a new feature transform named local daisy feature transform (LDFT), which is not only globally but also locally invariable. Then, the binary space partitioning (BSP) tree is used to partition the geometrically invariant LDFT space. In the BSP tree, the location of each pixel is fixed under global transform, local transform, and cropping. Lastly, the watermarking sequence is embedded bit by bit into each leaf node of the BSP tree by using the logarithmic quantization index modulation watermarking embedding method. Simulation results show that the proposed watermarking scheme can survive numerous kinds of distortions, including common image-processing attacks, local and global DAs, and noninvertible cropping.

  9. Tailoring the time delay of optical pulse/sequence employing cascaded SOA and band-pass filter

    NASA Astrophysics Data System (ADS)

    Wang, Fu; Wang, Zhi; Wu, Chongqing; Mao, Yaya; Shang, Chao; Gao, Kaiqiang; Li, Qiang

    2016-06-01

    A tunable time delay for a 100-ps pulse is achieved via a SOA cascaded band-pass filter, which can be tailored by tuning the filter or changing the SOA injection current. For a single pulse, when the pulse propagates through the cascaded system, a delay of 99.6 ps and an advance of 42.6 ps can be achieved by altering the SOA injection current at two different wavelengths located in the red band and blue band of the filter, respectively. The corresponding tunable delay range is 165 ps, and the maximum delay-bandwidth product (DBP) is 1.65. For an optical sequence, to our knowledge, it is the first time that the time delay is tailored over 145.6 ps corresponding to a DBP of 1.46 by tuning the wavelength from 1556.075 to 1556.955 nm, and 45.2 ps (95.6 ps) advance (delay) by tuning the injection current from 100 to 500 mA at 1556.155 nm (1556.955 nm). The dependence of the time delay on the injection current and filtering configuration has been discussed based on plenty of experiments data. Based on SOA's fast switching, this device can be used for signal synchronization and bit-by-bit signal processing in a communication system.

  10. Cue depreciation: when word fragment completion is undermined by prior exposure to lesser fragments.

    PubMed

    Peynircioğlu, Z F; Watkins, M J

    1986-07-01

    The ability to think of a previously studied item has often been shown to be impaired when, in one way or another, the extraitem context is changed from study to test. In a series of five experiments, such impairment is induced in a somewhat different way. A fragment (e.g. r-i--rop) of a just-studied word (raindrop) is shown to be less readily completed if it is presented bit by bit (r------p, r----r-p, r-i--r-p, r-i--rop) rather than all at once (Experiments 1, 3, 4, and 5). No such effect is found if the word has not been studied beforehand (Experiments 2, 3, 4, and 5). This pattern of results occurs even when fragments of studied and nonstudied words occur in the same test and under conditions in which subjects cannot tell whether a given fragment is of a studied or nonstudied word (Experiments 4 and 5). In addition, for words that have been studied beforehand, the impairment is shown to increase systematically with the number of steps involved in the presentation of the word fragment (Experiment 3) and also to persist when the time allowed for completion of the final version of the fragment is increased from 4 s to a full minute (Experiment 5).

  11. Maximum-Entropy Inference with a Programmable Annealer

    PubMed Central

    Chancellor, Nicholas; Szoke, Szilard; Vinci, Walter; Aeppli, Gabriel; Warburton, Paul A.

    2016-01-01

    Optimisation problems typically involve finding the ground state (i.e. the minimum energy configuration) of a cost function with respect to many variables. If the variables are corrupted by noise then this maximises the likelihood that the solution is correct. The maximum entropy solution on the other hand takes the form of a Boltzmann distribution over the ground and excited states of the cost function to correct for noise. Here we use a programmable annealer for the information decoding problem which we simulate as a random Ising model in a field. We show experimentally that finite temperature maximum entropy decoding can give slightly better bit-error-rates than the maximum likelihood approach, confirming that useful information can be extracted from the excited states of the annealer. Furthermore we introduce a bit-by-bit analytical method which is agnostic to the specific application and use it to show that the annealer samples from a highly Boltzmann-like distribution. Machines of this kind are therefore candidates for use in a variety of machine learning applications which exploit maximum entropy inference, including language processing and image recognition. PMID:26936311

  12. Target azimuth estimation for automatic tracking in range-gated imaging

    NASA Astrophysics Data System (ADS)

    Cao, Yinan; Wang, Xinwei; Zhou, Yan

    2012-11-01

    Target tracking is of great importance in imaging system, which can be applied in surveillance, as well as salvage and rescue where 3D spatial coordinates are used to locate the target. Range-gated imaging system is capable of acquiring range information of targets. However, azimuth is also necessary to provide the spatial coordinates to achieve target tracking. This paper presents a target azimuth estimation method for range-gated imaging system, aiming at obtaining essential information for vision-based automatic tracking. Due to the noise and low contrast of range-gated image, median filter and histogram equalization are used. Then the Otsu method is performed to make the segmentation of target and background. After segmentation, morphologic transformation methods will be taken in order to delete false targets. With pixels of target extracted from the image, the centoid will be derived. Next the pinhole camera model is applied to work out the azimuth coordinate. Since the focus length of camera is needed in the formula, an NC (Numerical Control) zoom module is developed. In this module, a sliding potentiometer is connected to the focus motor in camera, which serves as a feedback of the focus. To read the focus length and control the focus motor, an MCU (with AD converter) is used. Once the target azimuth information is obtained, the pan-tilt control unit can track the target bit by bit automatically.

  13. Biological neural networks as model systems for designing future parallel processing computers

    NASA Technical Reports Server (NTRS)

    Ross, Muriel D.

    1991-01-01

    One of the more interesting debates of the present day centers on whether human intelligence can be simulated by computer. The author works under the premise that neurons individually are not smart at all. Rather, they are physical units which are impinged upon continuously by other matter that influences the direction of voltage shifts across the units membranes. It is only the action of a great many neurons, billions in the case of the human nervous system, that intelligent behavior emerges. What is required to understand even the simplest neural system is painstaking analysis, bit by bit, of the architecture and the physiological functioning of its various parts. The biological neural network studied, the vestibular utricular and saccular maculas of the inner ear, are among the most simple of the mammalian neural networks to understand and model. While there is still a long way to go to understand even this most simple neural network in sufficient detail for extrapolation to computers and robots, a start was made. Moreover, the insights obtained and the technologies developed help advance the understanding of the more complex neural networks that underlie human intelligence.

  14. Control and Stabilization of bit-wise phase correlation in 160 (4 x 40) Gbit/s OTDM signal and its impact on transmission.

    PubMed

    Kagawa, Masatoshi; Murai, Hitoshi; Tsuji, Hiromi; Sasaki, Kensuke; Fujii, Kozo

    2008-07-01

    Detail of control technique of bit-wise phase correlation in 160 (4 x 40) Gbit/s optical time division multiplexing (OTDM) signal using a phase-correlation monitor based on 1-bit delay asymmetric interferometers (AIFs) is described. The 1-bit delay AIF transforms a bit-by-bit optical phase discontinuity to an optical power variation, so that it enables to quantify the phase-jump between adjacent bits. By use of this unique technique, we experimentally demonstrated stable generation of bitwisely phase-controlled 160 Gbit/s periodical alternate-phase return-to-Zero (APRZ) signal in addition to other different modulation formats such as conventional RZ, carrier suppressed RZ (CS-RZ), pair-wise alternate-phase CSRZ (PAP-CSRZ) and pi/2-APRZ. And long term stability was observed with CS-RZ signal. Also, we show some experimental results of 120 km un-repeatered transmission using standard single mode fiber (SSMF) and then discuss the impact of bit-wise phase change on 160 Gbit/s OTDM transmission performance.

  15. Ideas Worth Borrowing. Life Studies: Montana Students Tell the Story of a Place and Its People; Tales of Triumph: Fairy Tales Weave Connections between Generations; Everybody Writes: English Language Learners Discover Their Voice; Traveling by Post: "Paper Exchange Students" Explore the Globe; Learning by the Book: Students Publish a Series of Local Bestsellers; The Roots of Nikiski: Alaskan Students Discover Their Heritage and Leave a Legacy of Their Own; Riding "La Alfombra Magica": ESL Students Explore Their Roots....

    ERIC Educational Resources Information Center

    Boss, Suzie; Sherman, Lee; Linik, Joyce Riha; Reed, Bracken

    2002-01-01

    Seven classroom projects that motivate student writing in Northwest schools are described. The projects vary in grade level. Themes include local history, fairy tales, "Flat Stanley" exchange students, student book publishing, art, poetry, and science. Common practices include having students write about local and personally meaningful topics,…

  16. The UNESCO Universal Declaration on Bioethics and Human Rights: protecting future generations and the quest for a global consensus.

    PubMed

    Salako, Solomon E

    2008-12-01

    Since the coining of the term 'ectogenesis' by Haldane in 1924, we have witnessed sensational biotechnological triumphs such as in vitro fertilisation, the cloning of "Dolly" the sheep, and the publication of the human genetic code. These triumphs mix benefits with portents in one seamless package. The object of this article is to assess critically the Universal Declaration on Bioethics and Human Rights. It is argued that the Declaration is not a suitable international instrument for regulating biotechnology and protecting future generations. Finally, the feasibility of a legally binding international instrument based on a global consensus is evaluated. PMID:19202858

  17. Molecular Pathology of Dilated Cardiomyopathies.

    PubMed

    Pathak, S K; Kukreja, R C; Hess, M

    1996-02-01

    The term idiopathic, defined as being of unknown etiology or mechanism, is no longer applicable to the dilated cardiomyopathies. The tools of molecular biology and clinical investigation have made significant progress, and it is now to the rare and exceptional case that one is forced to apply the term idiopathic. Further, having arrived at more precise cause, direct therapeutic intervention will become possible. The concept of gene insertion and "genetic therapy" is under active investigation. Unfortunately, the significant advances in the cause and disease mechanisms of DCM have not been matched in therapeutics. With few exceptions, we indirectly treat the DCMs by managing the CHF syndrome. However, several important points have emerged. The concept of LV afterload reduction is valid and efficacious. The use of vasodilator therapy has significantly reduced both mortality and morbidity and, in certain forms of cardiomyopathy (e.g., hypertensive, alcoholic, and doxorubicin-related), have significantly altered hemodynamics and permitted the injured heart to heal and return to a near normal functional state. However, as much as we want to congratulate ourselves on the progress bought with the use of vasodilators and ACE inhibitors, one must keep in mind that under the best of circumstances, the DCMs still carry an unacceptably high morbidity and mortality. A 40% to 50% 4- to 5-year mortality rate is depressing. Herein lies the challenge. With the significant progress in pathogenesis and etiology, we now stand at the threshold of new, innovative advances in therapeutics. These new concepts in both therapeutics and prevention will require courage, dedication, and hard work. But bit by bit, these seemingly insolvable problems will yield to the discipline and imagination of the investigator. The DCMs will continue to be a challenging problem for future investigators. Progress has been dramatic, and it should continue even at an accelerated pace as we approach the twenty

  18. Flow Redistribution Between Legs and Brain During STS 93 Re-Entry and Landing

    NASA Technical Reports Server (NTRS)

    Arbeille, P.; Meck, J.; Porcher, M.; Benavides, E.; Martin, D. S.; South, D. A.; Ribeiro, C.; Westover, A.

    2003-01-01

    The objective was to quantify bit by bit the arterial hemodynamic response to the successive acceleration induced fluid shifts during re-entry and landing. Method: The astronaut instrumented himself with a flat Doppler probe fixed on the skin, a blood pressure arm cuff, and 3 ECG electrodes. The ICMS (integrated cardiovascular monitoring system, 15x15x25 cu cm, battery powered) designed to monitor Blood pressure, ECG, cerebral and femoral flows was fixed below the astronaut sit in the middeck. Recordings started 5 minutes before de-orbiting (TIG) and stopped 5 min after wheels stop. Results. During re-entry blood pressure increased by 20% at TIG, and then by 25 to 30% during the highest Gz accelerations (approx 1 S g ) . The cerebral flow remained decreased by 10 to 15% below inflight value all during the Entry and landing phases. Conversely the femoral flow increased at TIG and entry ( + l0 to 20%), recovered at 0.lg, and then decreased in proportion with the Gz acceleration (-10% to -40% from 0.5g to 1.5g). The reduction in Femoral flow was associated with an opposite variation in lower limb vascular resistance. Consequently the cerebral flow/femoral flow ratio decreased at TIG and entry (-20%), and then increased according to the Gz acceleration level ( + l0 to +40% from 0.5 to 1.5g). Conclusion: During orthostatic tests (Stand LBNP tests) the cerebral to femoral flow ratio allowed to quantify the efficiency of the flow redistribution between these 2 areas and predicted orthostatic intolerance. In the present case the astronaut was found orthostatically tolerant at postflight tilt tests, but we suggest that during re-entry this parameter could predict the occurrence of syncope in severely disadapted astronauts.

  19. Into the Community and Not on the Shelf: Learning to Develop a Meaningful HIV/AIDS Curriculum for Multiple Communities

    ERIC Educational Resources Information Center

    Riley, Tasha

    2014-01-01

    This paper describes the process involved in creating a community-based training curriculum designed to build capacity and foster new knowledge in support of HIV/AIDS education. Highlighted are the challenges and triumphs incurred while working with community and academic partners to ensure the production of an adaptable curriculum designed to…

  20. Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy

    ERIC Educational Resources Information Center

    Damsen, Silver

    2009-01-01

    My dissertation, "Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy" demonstrates how increased crown authority, and an expanded market combine with the mixed agency of the romantic comedy daughter to further encourage early modern economic growth. The triumph of rebelling daughter over blocking father has…

  1. DISINFECTION BYPRODUCTS: THE NEXT GENERATION

    EPA Science Inventory

    Disinfection of drinking water is rightly hailed as a major public health triumph of the 20th Century. Before widespread disinfection of drinking water in the U.S. and Europe, millions of people died from infectious waterborne diseases, such as typhoid and cholera. The microbia...

  2. U.S. EPA’s Four Lab Study: Integrated Assessment of Complex Disinfection Byproduct Mixtures - Abstract

    EPA Science Inventory

    Chemical disinfection of drinking water is considered one of the major public health triumphs of the 20th century, as it reduces concentrations of potentially pathogenic microorganisms resulting in corresponding decreases in morbidity and mortality from water-borne diseases. An ...

  3. Disinfection By-Products and Drinking Water Treatment

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Before its widespread use, millions of people died from waterborne diseases. Now, people in developed nations receive quality drinking water every day from their public wa...

  4. Understanding Richard Wright's "Black Boy": A Student Casebook to Issues, Sources, and Historical Documents.

    ERIC Educational Resources Information Center

    Felgar, Robert

    In "Black Boy," Richard Wright triumphs over an ugly, racist world by fashioning an inspiring, powerful, beautiful, and fictionalized autobiography. To help students understand and appreciate his story in the cultural, political, racial, social, and literary contexts of its time, this casebook provides primary historical documents, collateral…

  5. 76 FR 63807 - Leif Erikson Day, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... undersized sloop named Restauration, these brave travelers sought new opportunities and embraced the same... the promise of adventure and dreams of new discoveries. When they landed in modern day Canada, they.... The triumphs of Erikson and those who followed inspire us to continue reaching for new...

  6. God's Turnstile: The Work of John Wheeler and Stephen Hawking.

    ERIC Educational Resources Information Center

    Overbye, Dennis

    1991-01-01

    Presents an excerpt from the book entitled "Lonely Hearts of the Cosmos." Provides narration of behind-the-scenes events in the lives, the scientific debates, and the intellectual triumphs of the two physicists responsible for inventing the concept of the black hole. (JJK)

  7. Finding Meaning in PDS Stories

    ERIC Educational Resources Information Center

    Breault, Rick A.

    2010-01-01

    The Professional Development School (PDS) literature is filled with the stuff of good storytelling--archetypes of an ancient profession, struggles of marginalized individuals against powerful structures, personal triumphs, and devotion to a quest. However, much of the writing about PDS experiences that could be considered storytelling tends to…

  8. The Anguish of Leadership.

    ERIC Educational Resources Information Center

    Patterson, Jerry

    Despite their prominence, the voices of superintendents are rarely heard regarding their personal triumphs and challenges in educational administration and serving the needs of students. Chapter 1, "A Look at the Featured Superintendents," introduces 14 superintendents and reviews their careers. Chapter 2, "The Good: Dealing With Tough Issues By…

  9. Universal Newborn Screening and Adverse Medical Outcomes: A Historical Note

    ERIC Educational Resources Information Center

    Brosco, Jeffrey P.; Seider, Michael I.; Dunn, Angela C.

    2006-01-01

    Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and…

  10. "The Brain within Its Groove": Language and Struggling Students

    ERIC Educational Resources Information Center

    De Mers, Kathleen D.

    2010-01-01

    Words are the foundation of literacy. Words can express, in part, the joys, loves, triumphs, and sorrows of life. One person's thoughts, expressed through words, can powerfully influence and inspire audiences or readers and long outlive their author. But not everyone is enamored of words. For some students, words are a kind of torture. For them…

  11. The Courage of Their Convictions: Empowering Voices of Girls.

    ERIC Educational Resources Information Center

    Will, Katherine

    1994-01-01

    Reviews childhood trauma/abuse experienced by Maya Angelou and discusses how Angelou survived and triumphed over these experiences. Relates Angelou's story to moral developmental theory for women proposed by Carol Gilligan, focusing on Gilligan's metaphor of having a "voice." (NB)

  12. Liberating the Enlightenment: How a Transformed Relationship with Animals Can Help Us Transcend Modernity

    ERIC Educational Resources Information Center

    Williams, Cassandra D.

    2003-01-01

    The Enlightenment rejection of the Cartesian mechanistic understanding of animals was accompanied by a (re)new(ed) anti-cruelty sentiment. Compassion, however, fell victim to the triumph of reason leading Western culture toward an era of cruelty to animals on an unprecedented scale. What was absent in Enlightenment thought, even among proponents…

  13. Disinfection By-Products: Formation and Occurrence in Drinking Water

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the twentieth century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended he...

  14. The Next Generation of Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended health ...

  15. The Conundrums of the University's Ideological Battlegrounds

    ERIC Educational Resources Information Center

    Nelson, Stephen J.

    2016-01-01

    The lively experiment that "is" the college and university in America is characterized by sustained struggles and tempered triumphs that have both undergirded and challenged the fundamental foundation of the academy. Large questions shape the framework of the academy in America. These include: ideological and political correctness, the…

  16. Hubble 2008: Science Year in Review

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Hubbles remarkable mission has now spanned 18 years. During that time, it has been at the nexus of perhaps the most exciting period of discovery in the history of astronomy. Simultaneously, Hubble has offered up some of the most daunting engineering challenges to humans working in space, and success in meeting those challenges has been among NASAs greatest triumphs.

  17. A Toxicological Perspective on Disinfection ByProducts

    EPA Science Inventory

    Disinfection of water is essential for reduction of microbes harmful to human health and chemical disinfection is considered one of the major public health triumphs of the 20th Century. An unintended consequence of disinfection with oxidizing chemicals is formation of disinfectio...

  18. 75 FR 6081 - National African American History Month, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... African American History Month, 2010 By the President of the United States of America A Proclamation In... slavery and oppression, the hope of progress, and the triumph of the American Dream. African American..., I, BARACK OBAMA, President of the United States of America, by virtue of the authority vested in...

  19. Unfencing the Range: History, Identity, Property, and Apocalypse in "Lame Deer Seeker of Visions."

    ERIC Educational Resources Information Center

    Sanborn, Geoff

    1990-01-01

    Seemingly chaotic to Western eyes, John Lame Deer's autobiography has a meaningful structure based on Lakota numerology and oral tradition. The book explores conflicts between White and Indian conceptions of identity and property, and sees itself as an instrument in the apocalyptic triumph of Indian spirituality over White greed. (SV)

  20. Early Childhood Development in South Africa--Progress Since the End of Apartheid

    ERIC Educational Resources Information Center

    Atmore, Eric

    2013-01-01

    In April 1994, South Africa held its historic first democratic election. The African National Congress overwhelmingly triumphed and Nelson Mandela became the first president of a free and democratic South Africa. In this review, the situation of South Africa's young children under apartheid and the context of young children in South Africa in…

  1. Let Freedom Ring! Bulletin, 1937, No. 32

    ERIC Educational Resources Information Center

    Calhoun, Harold G.; Calhoun, Dorothy; Hatch, Roy W.; Cohen, Philip H.; Schramm, Rudolf

    1937-01-01

    This volume of "Let Freedom Ring!" contains the scripts of the 13 national broadcasts of the radio series of that name presented in the spring of 1937 over the national network of the Columbia Broadcast System. In "Let Freedom Ring!" you will find the courage, the struggle, the triumph of men and women who fought to win and safeguard liberties…

  2. The Next Generation of Drinking Water Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Millions of people worldwide receive quality drinking water every day from their public water systems. However, chemical disinfection has also produced an unintended healt...

  3. What Gets a Cell Excited? Kinky Curves

    ERIC Educational Resources Information Center

    Kay, Alan R.

    2014-01-01

    Hodgkin and Huxley's (5) revealing the origins of cellular excitability is one of the great triumphs of physiology. In an extraordinarily deft series of papers, they were able to measure the essential electrical characteristics of neurons and synthesize them into a quantitative model that accounts for the excitability of neurons and other…

  4. Using the GRAPES OF WRATH in the History Classroom.

    ERIC Educational Resources Information Center

    Mills, Randy

    1987-01-01

    Maintains that literary fiction may be used to enhance students' understanding of an historical period. Demonstrates how Steinbeck's GRAPES OF WRATH may be used to convey the human side of problems, sufferings, and triumphs that the United States experienced during the Great Depression. (JDH)

  5. Transition Brief: Policy Recommendations on Preparing Americans for the Global Skills Race

    ERIC Educational Resources Information Center

    Partnership for 21st Century Skills, 2008

    2008-01-01

    The central economic competitiveness issue for the Obama administration is creating an aligned, 21st century public education system that prepares students,workers and citizens to triumph in the global skills race. On Jan. 20, 2009, the Obama administration will take command of the White House facing unprecedented challenges to the U.S. economy…

  6. The Best of the Literacy Beat 1988-1989. The Best of the Literacy Beat 1987.

    ERIC Educational Resources Information Center

    Education Writers Association, Washington, DC.

    This document is a set of two volumes that contain prize-winning newspaper articles and summaries of radio and television shows selected as part of the Media Resource Project on Literacy. Items in the 1988-89 book include the following: "Why Daddy Can't Read" (Sally L. Gilman); "The Triumph of Jimmy Sanchez" (Sandra Macias); "Illiteracy:…

  7. Get the Federal Government out of Education? That Wasn't the Founding Fathers' Vision

    ERIC Educational Resources Information Center

    Jennings, Jack

    2011-01-01

    With the triumph of Tea Party candidates and other conservatives in 2010, many in the new Congress are pressing to get the federal government out of education. Eliminating or curtailing federal involvement in education would be a wrong-headed, simplistic move for several reasons: (1) It ignores the nation's history; (2) It would erode the state…

  8. Liberation Therapeutics: Consciousness Raising as a Problem.

    ERIC Educational Resources Information Center

    Lasch-Quinn, Elisabeth

    2002-01-01

    Questions the content and form of consciousness raising as a mode of purveying knowledge or bringing about change by considering its emergence in the civil rights movement. Examines such books as "Black Rage" (William Grierand Price Cobbs), "Triumph of the Therapeutic" (Philip Reiff), "Where Do We Go From Here: Chaos or Community?" (Martin Luther…

  9. [Odontology and the beginning of cartesianism (1673--1650) (Rene Descartes)].

    PubMed

    Gysel, C

    1979-01-01

    In the seventeenth century the universities of the Netherlands underwent the influence of Descartes in all the faculties. In medicine three periods can be distinguished: in the first, pathology and therapy are still galenic; the second, by the application of the cartesian method, triumphs in physiology; and the third, corrected by the views of Newton is integrated in a moderate biomechanism.

  10. U.S. EPA’s Four Lab Study: Integrated Assessment of Complex Disinfection Byproduct Mixtures - Slides

    EPA Science Inventory

    Chemical disinfection of drinking water is considered one of the major public health triumphs of the 20th century, as it reduces concentrations of potentially pathogenic microorganisms resulting in corresponding decreases in morbidity and mortality from water-borne diseases. An ...

  11. Myasthenia Gravis Foundation of America

    MedlinePlus

    ... where parents can share their concerns, their triumphs, information and ideas. Take a look by searching MG Parents, or click here. Research News -- MG Vaccine? New Targets? New Diagnostics? The MGFA reached out to Dr. Jon Lindstrom, whose work, ... New Research Funding Announcement Transformative Research ...

  12. Western Hemisphere Conference on Persons with Disabilities. Conference Proceedings (Washington, D.C., March 14-18, 1993) = Conferencia Hemisferica Occidental sobre Personas con Discapacidades. Actas de la Conferencia. (Washington, D.C., 14 al 18 de Marzo de 1993).

    ERIC Educational Resources Information Center

    Kelley, Jerry D., Ed.; And Others

    This document presents the proceedings of a conference which brought together delegates and First Ladies representing western hemisphere nations to address needs and issues affecting people with disabilities in the Americas. It presents the texts of two keynote addresses: "Small Triumphs, Big Victories: A Global View of Persons with Disabilities,"…

  13. The Innovative Economy: Synergistic Partnerships, Workforce Demands, and Global Competition

    ERIC Educational Resources Information Center

    Merrell, Dennis F.

    2007-01-01

    This article depicts the dual triumphs achieved by York Technical College and business/industry in creating a win-win solution to address workforce needs and shortages. The unique approach to partnership described is called "The Innovative Economy." It allows local companies and the college to maximize assets by providing exemplary showrooms with…

  14. The Role of Education in the Development of Black Feminist Thought, 1860-1920.

    ERIC Educational Resources Information Center

    Perkins, Linda M.

    1993-01-01

    Contends that the history of women's education in the United States is frequently told as a story of triumph over resistance and discouragement. Asserts that, in general, African American men viewed women with a greater sense of equality than was the norm within white society. (CFR)

  15. Dormancy of the barley grain is correlated with gibberellic Acid responsiveness of the isolated aleurone layer.

    PubMed

    Schuurink, R C; Sedee, N J; Wang, M

    1992-12-01

    The relationship between barley grain dormancy and gibberellic acid (GA(3)) responsiveness of aleurone layers has been investigated. Barley (Hordeum distichum L. cvs Triumph and Kristina) grains were matured under defined conditions in a phytotron. Grains of Triumph plants grown under long-day/warm conditions had lower dormancy levels than grains of plants grown under short-day/cool conditions. Aleurone layers isolated from grains of long-day Triumph plants secreted more alpha-amylase and had a higher responsiveness to GA(3) as measured by alpha-amylase secretion. Storage of the grains increased both the percentage of germination and the responsiveness of the aleurone to GA(3). Use of different sterilization methods to break dormancy confirmed the correlation between germination percentage and aleurone layer GA(3) responsiveness. The response of embryoless Triumph grains to GA(3) was lower than that of the isolated aleurone layers, suggesting a role of the starchy endosperm in regulating the GA(3) response of the aleurone layer. Grains of the cultivar Kristina harvested from short day- and long day-grown plants lacked dormancy, and their isolated aleurone layers had a similar responsiveness to GA(3) as measured by alpha-amylase secretion. The data indicate that the physiological state of the aleurone layers contributes to the percentage germination of the grains.

  16. Proclamations from Adult New Readers. Ratified September 10, 1989. National Adult Literacy Congress (2nd, Washington, D.C., September 9-11, 1989).

    ERIC Educational Resources Information Center

    Laubach Literacy International, Syracuse, NY.

    This report contains 10 proclamations prepared by adult new readers at a national conference in September 1989. The proclamations are the result of the new readers' deliberations. They represent the viewpoints of adults who have known firsthand the hardships of illiteracy and the triumph of learning to read. Each proclamation consists of a…

  17. Finnish Higher Education Reforms: Responding to Globalization

    ERIC Educational Resources Information Center

    Tjeldvoll, Arild

    2009-01-01

    The international academic success of Finnish secondary schooling in the Program for International Student Assessment (PISA) and the triumph of the Finnish technology company NOKIA have stimulated national ambitions to improve higher education institutions in Finland. Because secondary schooling and technology in Finland receive world recognition,…

  18. Women as Leaders in Education: Succeeding Despite Inequity, Discrimination, and Other Challenges. Women and Careers in Management

    ERIC Educational Resources Information Center

    Martin, Jennifer L., Ed.

    2011-01-01

    This up-to-date, candid examination of women's careers in education and leadership in education describes the pitfalls, triumphs, and future promise of female leaders in education. Despite the gains women have made in higher education over the past few decades, and an increasing number of well-qualified female candidates, they are still…

  19. On the Development of Democratic Citizens.

    ERIC Educational Resources Information Center

    Chance, Jerry M.

    1993-01-01

    Contends that the end of the Cold War does not necessarily mean the triumph of democracy. Presents contemporary interpretations of the democratic concepts of liberty, equality, and fraternity. Asserts that responsible action in a democratic society requires continued reflection about values education. (CFR)

  20. Performance Reporting: The Preferred "No Cost" Accountability Program--The Sixth Annual Report.

    ERIC Educational Resources Information Center

    Burke, Joseph C.; Minassians, Henrik

    This report presents information from the Sixth Annual Survey of State Higher Education Officers, and once again provides information on performance funding, budgeting, and reporting in all 50 states. Survey results show the triumph of performance reporting and the trials of performance budgeting and funding. The bad budgets for higher education…

  1. Yes, No, or Maybe? Transitions in Chilean Society in Pablo Larraín's "No"

    ERIC Educational Resources Information Center

    Howe, Alexis

    2015-01-01

    Pablo Larraín's film "No" (2012) has been widely viewed and reviewed both at home in Chile and internationally. Some reviewers have focused on the film's representation of the triumph of hope and optimism over tyranny. Others have criticized the film's historical inaccuracy, citing a list of details that the film either got wrong or left…

  2. Stories from Hopescapes

    ERIC Educational Resources Information Center

    Harris, Violet J.

    2011-01-01

    Author Virginia Hamilton had the gift of creating lyrical phrases that captured the complexities of life. Among her most notable phrase is the idea of the "hopescape," the metaphoric description of the pains and joys, triumphs and defeats, longing, and dreams that make us human. The publication of an edited volume that compiles a sampling of…

  3. Teaching Dance to Deaf Students: A Case Study in Cape Coast, Ghana

    ERIC Educational Resources Information Center

    Hampton, Tarin T. D.

    2013-01-01

    This article focuses on the challenges and triumphs of teachers who guide students with visual and auditory impairments to learn about and experience African-based dance as part of a healthy, active lifestyle. The teachers share insights they have gained in developing best practices by capturing the inherent nature of dance as kinesthetic…

  4. It's a Gift: "Ray," "The Incredibles" and Lives of Greatness

    ERIC Educational Resources Information Center

    Beck, Bernard

    2005-01-01

    The American biopic is an expression of distinctively American culture. Its story elements mirror the ideologies of mainstream America. The crucial ingredient in a biopic or a cartoon classic is the triumph of an indomitable struggler in circumstances that crush everyone else. "Ray" is an example of the biopic in its strongest and most affecting…

  5. American Album: 200 Years of Constitutional Democracy. Law in U.S. History. Law in Social Studies Series.

    ERIC Educational Resources Information Center

    Suter, Coral; Croddy, Marshall

    This book explores the lives of people who have shaped the laws and legal system of the United States and describes their impact on the U.S. Constitution. The new government's beginnings are examined in unit 1, through the pitfalls and triumphs of the First Continental Congress. The role of John Marshall, the First Chief Justice of the Supreme…

  6. DEVELOPMENT OF A RESEARCH STRATEGY FOR INTEGRATED TECHNOLOGY-BASED TOXICOLOGICAL AND CHEMICAL EVALUATION OF COMPLEX MIXTURES OF DRINKING WATER DISINFECTION BYPRODUCTS

    EPA Science Inventory

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure ...

  7. Democratic Education through the Eyes of the Poor: Appraising the Post-Apartheid Experience

    ERIC Educational Resources Information Center

    Msila, Vuyisile

    2013-01-01

    Arguably, one of the major achievements in the 1990s in South Africa was the final toppling of apartheid government and the triumph of democracy over the unjust and unequal past legislation. Since then schools are some of the institutions that have infused democracy ideals into their policies, curriculum and other aspects of school life. The…

  8. Mass Spectrometry Identification of Toxicologically Important Drinking Water Disinfection By-Products

    EPA Science Inventory

    The disinfection of drinking water has been rightly hailed as a public health triumph of the 20th century. Before its widespread use, millions of people died from waterborne diseases. Now, people in developed nations receive quality drinking water every day from their public wate...

  9. The "Saggi" and Practical Work

    ERIC Educational Resources Information Center

    Melville, Wayne

    2013-01-01

    The "Saggi di naturali esperienze" was published in 1667 by one of the earliest scientific societies, the Accademia del Cimento. The book was a triumph for the ruling Medici family of Florence, and the commitment of the Accademia to experimentation helped the "Saggi" become the "laboratory manual" of the 18th century.…

  10. Academic Studies, Science, and Democracy: Conceptions of Subject Matter from Harris to Thorndike

    ERIC Educational Resources Information Center

    Watras, Joseph

    2009-01-01

    When Ellen Condliffe Lagemann described what she called the troubling history of education research, she claimed that, in the early years of the twentieth century, Edward Lee Thorndike's narrow model of science replaced John Dewey's more open ideas. According to Lagemann, sexism was an important reason for Thorndike's triumph. In describing the…

  11. Vaccination Policies Fall on Schools' Shoulders

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2007-01-01

    Vaccines are one of the triumphs of modern medicine, relegating many once-fearsome diseases to the history books. Denying access to school has long been the best way to ensure that children get vaccinated, but carrying out any change in immunization policy means a lot of work for school officials. This article discusses the unity of several…

  12. Does Watching Help? In Search of the Theory of Change for Education Monitoring

    ERIC Educational Resources Information Center

    Post, David

    2015-01-01

    In 2015 Education for All (EFA), concludes its 25-year cycle, and the Global Monitoring Report (GMR) publishes its final assessment of triumph and defeat in reaching the six EFA goals. Before the United Nations adopts new Sustainable Development Goals, it is essential to consider the underlying theories of monitoring. This essay addresses two…

  13. An Australian Science Curriculum: Competition, Advances and Retreats

    ERIC Educational Resources Information Center

    Aubusson, Peter

    2011-01-01

    Science schooling enjoys high status. Scientific capability is perceived as critical in underpinning economic success in advanced societies. Science achievement, at all levels, has become a global competition in which nations want to be seen to triumph. Governments periodically pay close attention to science education with a view to ensuring it…

  14. Tom Friedman on Education in the "Flat World"

    ERIC Educational Resources Information Center

    School Administrator, 2008

    2008-01-01

    In his best-selling book, "The World Is Flat," Thomas Friedman describes that the real world is becoming "flat." He describes how 10 forces are "flattening" the 21st century--making it easier for people in India, China and around the world to compete with Americans and others who had triumphed the century before. This article presents an interview…

  15. Vignettes from the Field: Stories from Four New Minority Teachers.

    ERIC Educational Resources Information Center

    Stallworth, B. Joyce

    The four narratives presented in this paper represent the classroom triumphs and tribulations of four beginning minority teachers. The vignettes are part of a larger case study investigating the specific socialization experiences of these new teachers, graduates of the Peabody College (Tennessee) Internship/Induction Program, an alternative…

  16. Bringing It All Back Home: An Innovative Approach to the Provision of Tailored Education and Training for Young People--The Experience of the Adult Better Learning and Education (ABLE) 18-21 Programme

    ERIC Educational Resources Information Center

    Craddock, Fergus

    2012-01-01

    The aim of this article is to give a brief overview of the context to the Adult Better Learning and Education (ABLE) 18-21 programme and the objectives which the programme aimed to fulfil in light of the challenges facing early school leavers. The article will also document the triumphs and challenges experienced by the participants when returning…

  17. Using Autobiography as a Vehicle to Study the Cultural Foundations of Twentieth Century African-American Education

    ERIC Educational Resources Information Center

    Hilton, Louis R., III

    2004-01-01

    In using the autobiographies of African-Americans as a heuristic, educators are provided with a context to view African-American educational history. The autobiographies of African-Americans tell stories of triumph over adversity as also revealed in Melba Beals' autobiography, "Warriors Don't Cry," a recount of the struggle to integrate Central…

  18. The Valley Forge Encampment: Epic on the Schuylkill.

    ERIC Educational Resources Information Center

    Trussell, John B. B., Jr.

    Valley Forge, outside Philadelphia (Pennsylvania), has long been recognized as the site of a great victory of the human spirit. Eleven thousand men including Blacks and Indians resided there during the winter of 1777-78 and triumphed over cold, starvation, nakedness, disease, and uncertainty. The encampment site was unprepared for the tattered,…

  19. Ayn Rand: Effective Educational Leadership Traits Compared to Selfishness

    ERIC Educational Resources Information Center

    Thompson, Barbara A.; Kritsonis, William Allan

    2009-01-01

    A man's self-interest cannot be determined by blind desires or random whims, feelings, urges, or wishes. His interest must be discovered and achieved by the guidance of rational principles that he chooses for himself. This selfishness is man's way to individual triumph over hardships. It is a virtue. Man must be guided by his own independent…

  20. Earth Day '70, '80, '90.

    ERIC Educational Resources Information Center

    Schoenfeld, A. Clay

    1981-01-01

    Uses objective and subjective data to document the triumphs and tragedies of the environmental movement and environmental education during the 1970's. Proposes that members of the National Association for Environmental Education dedicate themselves to a decade of integrated environmental management education. (DC)

  1. Toward a Theater of Understanding

    ERIC Educational Resources Information Center

    Silvera, Frank

    1969-01-01

    Praises the humanitarian value of a James Baldwin play, which pleads for compassion and understanding of another man's (here, the Negro's) point of view, trials and triumphs as a human being, and search to find meaning in the human predicament. (KG)

  2. The Power of Four (the 4-Lab Study): ORD’s Integrated Disinfection By-Products Mixtures Research Project

    EPA Science Inventory

    Chemical disinfection of water, a major public health triumph of the 20th century, has resulted in dramatic decreases in morbidity and mortality from water-borne disease. The intended result of chemical disinfection of drinking water is reduction of microbial contamination; the u...

  3. Murals as Monuments: Students' Ideas about Depictions of Civilization in British Columbia

    ERIC Educational Resources Information Center

    Seixas, Peter; Clark, Penney

    2004-01-01

    Around the world people confront monuments that celebrate historical origins, movements, heroes, and triumphs no longer seen as worthy of celebration. While an analysis of these "lieux de memoire" themselves can reveal historical consciousness, the sites become particularly interesting at the moment when they inspire debate, namely, when people…

  4. Consuming Prose: The Delectable Rhetoric of Food Writing

    ERIC Educational Resources Information Center

    Bloom, Lynn Z.

    2008-01-01

    Food writing, like cooking, offers control over at least a small slice of an otherwise refractory world. As practiced by writers so good that whether they can cook or not is beside the point, food writing is most often upbeat and nurturing, providing successes and triumphs--modest and major--for readers to feast on, with occasional glimpses of…

  5. Understanding Propaganda: The Epistemic Merit Model and its Application to Art

    ERIC Educational Resources Information Center

    Ross, Sheryl Tuttle

    2002-01-01

    Pablo Picasso's "Guernica," Francisco de Goya's "Fifth of May," Eugene Delacroix's "Liberty Leading the People," George Orwell's "Road to Wigan Pier," Leni Riefenstahl's "Triumph of the Will," and D. W. Griffith's "Birth of a Nation," are all examples of expressly political art. Historically some art has been not only an object of aesthetic…

  6. Classic and Modern Propaganda in Documentary Film: Teaching the Psychology of Persuasion

    ERIC Educational Resources Information Center

    Simpson, Kevin E.

    2008-01-01

    Primary source material found in documentary film has the potential to richly inform college teaching. This article describes using 2 historically significant documentary-style films to teach concepts in the psychology of persuasion. Exemplary clips taken from "Triumph of the Will" (Riefenstahl, 1935) and "Fahrenheit 9/11" (Moore, 2004)…

  7. 40 CFR 205.158 - Labeling requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HOD Honda HON Husqvarna HUS JAWA/CZ JAW Kawasaki KAW KTM KTM Laverda LAV Moto Benilli BEN Moto Guzzi GUZ Moto Morini MOR MV Agusta MVA Norton Triumph TRI Rokon ROK Suzuki SUZ Yamaha YAM (8) Moped... MAL Morini MOI Motobecane/Solex MBE Moto Guzzi GUZ Negrini NEG Odyssey ODY Pacer PAC Pack-A-Way...

  8. The burn disease: a disease of great value in the cultural heritage of plastic surgery.

    PubMed

    Mazzoleni, F

    2014-06-30

    in the practice of his profession while "listening and reading" everything that has happened to him during his work as a plastic surgeon over half a century. These opinions formed bit by bit; only now am I attempting to verify and justify them, intentionally seeking the bibliographic testimony and opinions of others.

  9. Real time, TV-based, point-image quantizer and sorter

    DOEpatents

    Case, Arthur L.; Davidson, Jackson B.

    1976-01-01

    A device is provided for improving the vertical resolution in a television-based, two-dimensional readout for radiation detection systems such as are used to determine the location of light or nuclear radiation impinging a target area viewed by a television camera, where it is desired to store the data indicative of the centroid location of such images. In the example embodiment, impinging nuclear radiation detected in the form of a scintillation occurring in a crystal is stored as a charge image on a television camera tube target. The target is scanned in a raster and the image position is stored according to a corresponding vertical scan number and horizontal position number along the scan. To determine the centroid location of an image that may overlap a number of horizontal scan lines along the vertical axis of the raster, digital logic circuits are provided with at least four series-connected shift registers, each having 512 bit positions according to a selected 512 horizontal increment of resolutions along a scan line. The registers are shifted by clock pulses at a rate of 512 pulses per scan line. When an image or portion thereof is detected along a scan, its horizontal center location is determined and the present front bit is set in the first shift register and shifted through the registers one at a time for each horizontal scan. Each register is compared bit-by-bit with the preceding register to detect coincident set bit positions until the last scan line detecting a portion of the image is determined. Depending on the number of shift registers through which the first detection of the image is shifted, circuitry is provided to store the vertical center position of the event according to the number of shift registers through which the first detection of the event is shifted. Interpolation circuitry is provided to determine if the event centroid is between adjacent scan lines and stored in a vertical address accordingly. The horizontal location of the event

  10. An international human becoming hermeneutic study of Tom Hegg's A cup of Christmas Tea.

    PubMed

    Baumann, S L; Carroll, K A; Damgaard, G A; Millar, B; Welch, A J

    2001-10-01

    This article seeks to contribute to human becoming theory and to nursing by providing an international human becoming hermeneutic study of Thomas Hegg's A Cup of Christmas Tea. The human becoming hermeneutic method was used in this study to discover emergent meanings about human experiences. Guided by the method, the authors discovered three emergent meanings: honoring the cherished; communing with the was, is, and will be; and triumphing with new vision. These meanings were synthesized by the authors. A Cup of Christmas Tea is the story of the way triumphing with new vision arises with honoring the cherished in communing with the was, is, and will be. The conclusion for families and nurses is that by remaining open to all possibilities that exist in each now, moments of serendipitous togetherness can transform human trepidation and negative views of later life.

  11. Untreatable infections?--The challenge of the 21st century.

    PubMed

    Parry, C M

    1998-06-01

    The triumph of antibiotics over bacterial pathogens that has occurred in the latter half of this century looks increasingly threatened as we approach the new millennium. Increasing resistance in important pathogens such as Mycobacterium tuberculosis, Shigella, and Streptococcus pneumoniae threatens the lives of millions. The increasing problems with drug resistance in (C. diphtheriae, Salmonella typhi and the pneumococcus in Vietnam are presented as examples of the challenge confronting tropical countries.

  12. Reflections on Behavior Analysis and Evolutionary Biology: A Selective Review of Evolution Since Darwin—The First 150 Years. Edited by M. A. Bell, D. J. Futuyama, W. F. Eanes, & J. S. Levinton

    PubMed Central

    Donahoe, John W

    2012-01-01

    This review focuses on parallels between the selectionist sciences of evolutionary biology and behavior analysis. In selectionism, complex phenomena are interpreted as the cumulative products of relatively simple processes acting over time—natural selection in evolutionary biology and reinforcement in behavior analysis. Because evolutionary biology is the more mature science, an examination of the factors that led to the triumph of natural selection provides clues whereby reinforcement may achieve a similar fate in the science of behavior.

  13. Migrating to 9.1 -- Why Not...How Hard Could It Be?

    NASA Technical Reports Server (NTRS)

    Little, Keith; Miller, Carole; Schwindt, Paul; Zimmerman, Cheryl

    2011-01-01

    With 19+ Million documents in the 8.0 Vault. the decision was to migrate only selected top-level Documents, Drawings, Models and Assemblies to Kennedy Space Center's Brand-Spankin-New 9.1 Windchill system. Come with us as we detail our journey. We'll share our triumphs. tools, and approaches, as well as our challenges (and a surprise or two) discovered on the trip.

  14. Riffing on the universe

    NASA Astrophysics Data System (ADS)

    Cox, Trevor

    2016-05-01

    Music and physics might seem like polar opposites, one having great emotional potency and the other being a cerebral subject of equations, theories and deductions. Both, however, benefit from improvisers - people who stand on the shoulders of giants, taking earlier triumphs and building on them to create something new. For me, analogies like these, which draw parallels between physicists and jazz musicians, are the most fascinating revelations in Stephon Alexander's book The Jazz of Physics.

  15. Understanding and Meeting the Needs of ESL Students

    ERIC Educational Resources Information Center

    Miller, Paul Chamness; Endo, Hidehiro

    2004-01-01

    One of the best ways to understand what it is like to be an English-language learner in a U.S. classroom is to hear the stories of immigrant students. In this article, the authors use these stories to determine what steps teachers can take to help their students triumph over their struggles with a new culture and a new language. This article…

  16. Robinson Crusoe: the fate of the British Ulysses.

    PubMed

    Pimentel, Juan

    2010-03-01

    If travel has been one of the leitmotifs of Western imagination, Robinson Crusoe has certainly been one of its foremost incarnations. This British Ulysses foretold the global village, but also its problems. He predicted the end of distance, but also the triumph of isolation and anaesthetized loneliness. This paper provides an overview of the connections between Defoe's narrative and the new science and explores two versions of the story by two contemporary writers, Julio Cortazar and John Maxwell Coetzee. PMID:20106528

  17. Robinson Crusoe: the fate of the British Ulysses.

    PubMed

    Pimentel, Juan

    2010-03-01

    If travel has been one of the leitmotifs of Western imagination, Robinson Crusoe has certainly been one of its foremost incarnations. This British Ulysses foretold the global village, but also its problems. He predicted the end of distance, but also the triumph of isolation and anaesthetized loneliness. This paper provides an overview of the connections between Defoe's narrative and the new science and explores two versions of the story by two contemporary writers, Julio Cortazar and John Maxwell Coetzee.

  18. Riffing on the universe

    NASA Astrophysics Data System (ADS)

    Cox, Trevor

    2016-05-01

    Music and physics might seem like polar opposites, one having great emotional potency and the other being a cerebral subject of equations, theories and deductions. Both, however, benefit from improvisers – people who stand on the shoulders of giants, taking earlier triumphs and building on them to create something new. For me, analogies like these, which draw parallels between physicists and jazz musicians, are the most fascinating revelations in Stephon Alexander's book The Jazz of Physics.

  19. What now, Asclepius? Lessons from Olympus.

    PubMed

    Moore, M R

    1996-10-01

    Asclepius, the Greek and Roman god of healing, is called before a council of gods on Mount Olympus to account for the shortcomings of his mortal descendants, the present day physicians. Accusations by the gods and Asclepius' defense and explanation bring the gods an understanding of human history and what physicians must become if humanity is to triumph over disease. Asclepius hopes the modern medical profession will understand also.

  20. Teaching To Learn: Reflections on Risk-Taking. Bill Harp Professional Teachers Library.

    ERIC Educational Resources Information Center

    Cusack, Margaret S.

    This book is a discussion of teaching as learning--rooted in the author's personal history as a teacher and learner, and offered as one story among many to help other teachers ask questions about their own practice. The book is not intended to be a manual or a step-by-step guide for use in the classroom. Instead, it emphasizes the triumphs that…

  1. Advances in the understanding and management of heart transplantation

    PubMed Central

    Singh, Dhssraj

    2015-01-01

    Cardiac transplantation represents one of the great triumphs in modern medicine and remains the cornerstone in the treatment of advanced heart failure. In this review, we contextualize pivotal developments in our understanding and management of cardiac transplant immunology, histopathology, rejection surveillance, drug development and surgery. We also discuss current limitations in their application and the impact of the left ventricular assist devices in bridging this gap. PMID:26097725

  2. Fast Tracks to Intelligence

    NASA Astrophysics Data System (ADS)

    Calvin, W. H.

    It is often assumed that the evolution of intelligence is inevitable, given the self-organizing seen in dissapative systems and the gradual shaping-up of Darwinism. While compound-interest reasoning suggests that small advantages will eventually triumph, eventually may be a very long time: there are few examples of rapid brain growth, suggesting that "smarter-is-better" is not a potent force for evolution.

  3. The Effect of a Soap Film on a Catenary: Measurement of Surface Tension from the Triangular Configuration

    ERIC Educational Resources Information Center

    Behroozi, F.; Behroozi, P. S.

    2011-01-01

    A chain assumes the well-known shape known as a catenary when it hangs loosely from two points in a gravitational field. The correct solution of the catenary was one of the early triumphs of the newly invented calculus of variations at the end of the 17th century. Here we revisit the catenary and show that, for a chain hanging from a horizontal…

  4. ORAL ISSUE OF THE JOURNAL "USPEKHI FIZICHESKIKH NAUK": Sixty years of broken symmetries in quantum physics (from the Bogoliubov theory of superfluidity to the Standard Model)

    NASA Astrophysics Data System (ADS)

    Shirkov, Dmitrii V.

    2009-06-01

    This is a retrospective historical review of the ideas that led to the concept of the spontaneous symmetry breaking (SSB), the issue that has been implemented in quantum field theory in the form of the Higgs mechanism. The key stages covered include: the Bogoliubov microscopic theory of superfluidity (1946); the Bardeen-Cooper-Schrieffer-Bogoliubov microscopic theory of superconductivity (1957); superconductivity as superfluidity of Cooper pairs (Bogoliubov, 1958); the extension of the SSB concept to simple quantum field models (early 1960s); triumph of the Higgs model in electroweak theory (early 1980s). The role and status of the Higgs mechanism in the current Standard Model are discussed.

  5. Megatrends for the information age.

    PubMed Central

    Aburdene, P

    1994-01-01

    The 1990s are a decade characterized by change. Technological advances and health care reform are changing the demand for and provision of biomedical information, while political, economic, and social change are transforming the larger environment. There are four important megatrends shaping the global future: the new world order, the renaissance of the arts, the triumph of the individual, and the decade of women in leadership. Preparing to take advantage of the opportunities created by these changes is essential for organizations to survive and for individuals to become leaders. PMID:8136755

  6. The second Jurassic dinosaur rush and the dawn of dinomania.

    PubMed

    Brinkman, Paul D

    2010-09-01

    During the second Jurassic dinosaur rush museum paleontologists raced to display the world's first mounted sauropod dinosaur. The American Museum of Natural History triumphed in 1905 when its Brontosaurus debuted before an admiring crowd of wealthy New Yorkers. The Carnegie Museum of Natural History in Pittsburgh, the Field Columbian Museum in Chicago and other institutions were quick to follow with their own sauropod displays. Thereafter, dinomania spread far and wide, and big, showpiece dinosaurs became a museum staple. This brief but intensely competitive period of acquisitiveness fostered important Jurassic dinosaur revisions and crucial innovations in paleontological field and lab techniques. PMID:20667597

  7. Forensic psychiatry and the birth of the criminal insane asylum in modern Italy.

    PubMed

    Gibson, Mary

    2014-01-01

    This paper focuses on the creation of the criminal insane asylum in Italy between unification in 1861 and World War I. The establishment of criminal insane asylums was a triumph of the positivist criminology of Cesare Lombroso, who advocated for an institution to intern insane criminals in his classic work, Criminal Man (1876). As a context for the analysis of the birth of the criminal insane asylum in Italy, this essay also outlines the history of the insanity plea in Italian criminal law and the young discipline of psychiatry during the fifty years after Italian unification.

  8. Mathematical universality and direct applicability of evolutionary games. Comment on "Universal scaling for the dilemma strength in evolutionary games", by Z. Wang et al.

    NASA Astrophysics Data System (ADS)

    Arranz, Jordi; Traulsen, Arne

    2015-09-01

    The application of classical game theory to biological sciences allowed researchers to successfully approach problems in theoretical and evolutionary biology in a novel manner [1]. Among those, the evolution of cooperation is the most popular application of evolutionary game theory. The evolution of cooperation is traditionally modeled through games, in particular social dilemmas. These depict situations, in which the interest of an individual is in conflict with the interest of the group, thus games offer an ideal ground to study how cooperation can emerge in the face of natural selection, where individual advantage triumphs over group benefits.

  9. The second Jurassic dinosaur rush and the dawn of dinomania.

    PubMed

    Brinkman, Paul D

    2010-09-01

    During the second Jurassic dinosaur rush museum paleontologists raced to display the world's first mounted sauropod dinosaur. The American Museum of Natural History triumphed in 1905 when its Brontosaurus debuted before an admiring crowd of wealthy New Yorkers. The Carnegie Museum of Natural History in Pittsburgh, the Field Columbian Museum in Chicago and other institutions were quick to follow with their own sauropod displays. Thereafter, dinomania spread far and wide, and big, showpiece dinosaurs became a museum staple. This brief but intensely competitive period of acquisitiveness fostered important Jurassic dinosaur revisions and crucial innovations in paleontological field and lab techniques.

  10. Nobel Prize in Chemistry. Development of the Olefin Metathesis Method in Organic Synthesis

    NASA Astrophysics Data System (ADS)

    Casey, Charles P.

    2006-02-01

    The 2005 Nobel Prize in Chemistry was awarded to Yves Chauvin of the Institut Français du Pétrole, Robert H. Grubbs of CalTech, and Richard R. Schrock of MIT "for development of the metathesis method in organic synthesis". The discoveries of the laureates provided a chemical reaction now used daily in the chemical industry for the efficient and more environmentally friendly production of important pharmaceuticals, fuels, synthetic fibers, and many other products. This article tells the story of how olefin metathesis became a truly useful synthetic transformation and a triumph for mechanistic chemistry, and illustrates the importance of fundamental research. See JCE Featured Molecules .

  11. Hubble Space Telescope - Scientific, Technological and Social Contributions to the Public Discourse on Science

    NASA Technical Reports Server (NTRS)

    Wiseman, Jennifer

    2012-01-01

    The Hubble Space Telescope has unified the world with a sense of awe and wonder for 2 I years and is currently more scientifically powerful than ever. I will present highlights of discoveries made with the Hubble Space Telescope, including details of planetary weather, star formation, extra-solar planets, colliding galaxies, and a universe expanding with the acceleration of dark energy. I will also present the unique technical challenges and triumphs of this phenomenal observatory, and discuss how our discoveries in the cosmos affect our sense of human unity, significance, and wonder.

  12. Experimental Semiconductor Physics: The Will to Contribute to the Country’s Economic Development

    NASA Astrophysics Data System (ADS)

    Vigil Santos, Elena

    During the second half of the 1960s the Physics School staff increased sharply. Before this, it had experienced near depletion due to the emigration of many of its members shortly after the triumph of the Revolution. This renaissance took place thanks to the incorporation of the first physicists to graduate from the Physics School itself, and to the return of those who had graduated abroad, mainly from the former Soviet Union. This group of young physicists—with a heavy schedule of teaching duties in spite of their lack of experience—gave strong support to the development of physics in Cuba.

  13. Forensic psychiatry and the birth of the criminal insane asylum in modern Italy.

    PubMed

    Gibson, Mary

    2014-01-01

    This paper focuses on the creation of the criminal insane asylum in Italy between unification in 1861 and World War I. The establishment of criminal insane asylums was a triumph of the positivist criminology of Cesare Lombroso, who advocated for an institution to intern insane criminals in his classic work, Criminal Man (1876). As a context for the analysis of the birth of the criminal insane asylum in Italy, this essay also outlines the history of the insanity plea in Italian criminal law and the young discipline of psychiatry during the fifty years after Italian unification. PMID:24210450

  14. [Studies of the system analysis of social motivation, IV: The varieties of smiling and the problem of motivational adjustment].

    PubMed

    Bischof, N

    1996-01-01

    A formal theory is proposed that accounts for the motivational architecture underlying the spontaneous smiling response in its most salient varieties (i.e., smiling due to security, relief, embarrassment, fear, amazement, submission, and triumph). The theory is based on a single assumption according to which the smiling response, in all instances named, is due to a reduction of "autonomy claim" as defined within the framework of the Zurich Model of Social Motivation. The theory's consistency is evinced by way of computer simulation, its phenomenological plausibility can be demonstrated by animation based on Ekman's Facial Action Coding System.

  15. Radiation from an accelerating neutral body: The case of rotation

    NASA Astrophysics Data System (ADS)

    Yarman, Tolga; Arik, Metin; Kholmetskii, Alexander L.

    2013-11-01

    When an object is bound at rest to an attractional field, its rest mass (owing to the law of energy conservation, including the mass and energy equivalence of the Special Theory of Relativity) must decrease. The mass deficiency coming into play indicates a corresponding rest energy discharge. Thus, bringing an object to a rotational motion means that the energy transferred for this purpose serves to extract just as much rest mass (or similarly "rest energy", were the speed of light in empty space taken to be unity) out of it. Here, it is shown that during angular acceleration, photons of fundamental energy are emitted, while the object is kept on being delivered to a more and more intense rotational accelerational field, being the instantaneous angular velocity of the rotating object. This fundamental energy, as seen, does not depend on anything else (such as the mass or charge of the object), and it is in harmony with Bohr's Principle of Correspondence. This means at the same time, that emission will be achieved, as long as the angular velocity keeps on increasing, and will cease right after the object reaches a stationary rotational motion (a constant centrifugal acceleration), but if the object were brought to rotation in vacuum with no friction. By the same token, one can affirm that even the rotation at a macroscopic level is quantized, and can only take on "given angular velocities" (which can only be increased, bit by bit). The rate of emission of photons of concern is, on the other hand, proportional to the angular acceleration of the object, similarly to the derivative of the tangential acceleration with respect to time. It is thus constant for a "constant angular acceleration", although the energy of the emitted photons will increase with increasing , until the rotation reaches a stationary level, after which we expect no emission --let us stress-- if the object is in rotation in vacuum, along with no whatsoever friction (such as the case of a rotating

  16. Importance of Technical Writing in Engineering Education

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2010-12-01

    ., Grasha, A., & Richlin, L. (1997, March). Town meeting. Between teaching model and learning model: Adapting and adopting bit by bit. Paper presented at the ninth annual Lilly Conference on College and University Teaching - West, Lake Arrowhead, CA. Narayanan, Mysore (2009). Assessment Based on the principles of Theodore Marchese. ASEE 116th Annual Conference and Exposition, Austin, TX. June 14-17, 2009. Paper # AC 2009-1532. Saxe, S. (1990, June). Peer influence and learning. Training and Development Journal, 42 (6), 50-53. Senge, P. M. (1990). The fifth discipline: The art and practice of the learning organization. New York: Currency Doubleday. Sims, R. R. (1992, Fall). Developing the learning climate in public sector training programs. Public Personnel Management, 21 (3), 335-346. Kosakowski, John, (1998). The Benefits of Information Technology. ERIC Digests; Technology Integration; Technology Role, ED0-IR-98-04 Chaika, Gloria (2000), Encourage Student Writing: Published on the Web, Education World http://www.education-world.com/a_tech/tech042.shtml

  17. Ground deformation cycles participating with sub-Plinian, Vulcanian eruptions, and a magma effusive stage at Kirishima volcanoes

    NASA Astrophysics Data System (ADS)

    Takeo, M.; Maehara, Y.; Ohminato, T.; Ichihara, M.; Oikawa, J.

    2012-12-01

    /or deflation steps associated with a volcanic glow or a phreatomagmatic eruption which occurred before the Vulcanian eruption. The time sequences of preceding inflations were progressively complicated through the frequent Vulcanian eruptions, and finally, deflation steps participating with a volcanic glow and a phreatomagmatic eruption were appeared during the preceding inflation periods of two Vulcanian eruptions on 7 February 2011. The progressive change of time sequences suggests that strength heterogeneity of filled magma had been gotten larger bit by bit through the repeating Vulcanian eruptions. In spite of the complicated time sequences of preceding inflations, we reveal the clear linearity with the constant gradient of 0.45 between the logarithm of preceding durations versus the elapsed time counting on the date time scale form the reference date of each sub-stage. These observations are consistently interpreted based on the concepts that a Vulcanian eruption is induced by a sudden fracturing of strongest magma frame due to overpressure caused by magma degassing, and amount of degassing from magma decline exponentially with progress of time.

  18. Writers, Athletes and Engineers Learn by Doing

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2009-12-01

    provided evidence-based reasoning and critical thinking. 6. He/She has suggested a time-line for completing the assignment. 7. The person has completed the required process in the alloted time-line. In this presentation the author stresses the importance of writing assignments in engineering disciplines. References: Barr, R. B., & Tagg, J. (1995, November/December). From teaching to learning: A new paradigm for undergraduate education. Change: The Magazine of Higher Education, 13-24. Cox, M. D., Grasha, A., & Richlin, L. (1997, March). Town meeting. Between teaching model and learning model: Adapting and adopting bit by bit. Paper presented at the ninth annual Lilly Conference on College and University Teaching - West, Lake Arrowhead, CA. Narayanan, Mysore (2009). Assessment Based on the principles of Theodore Marchese. ASEE 116th Annual Conference and Exposition, Austin, TX. June 14-17, 2009. Paper # AC 2009-1532. Saxe, S. (1990, June). Peer influence and learning. Training and Development Journal, 42 (6), 50-53. Senge, P. M. (1990). The fifth discipline: The art and practice of the learning organization. New York: Currency Doubleday.

  19. The iceperson cometh: cryonics, law and medicine.

    PubMed

    Smith, G P

    1983-01-01

    The "New Biology" has already made profound impact on the law. Cryonics and genetic engineering represent technological triumphs. The natural, organic process of dying is being replaced by a humanly engineered technological process for living. The dying phase of life is prolonged until biological knowledge is available to reverse the dying phase and restore the living phase. Both cryonics and genetic engineering in their attempts to replace the organic process with the technological process disturb the delicate balance of the triad of life which each individual experiences--faith, health, and justice. Since law is a basic tool to achieve justice among human beings, how should it respond to the health argument of the cryonics' physician who views death as a disease which is curable? How should the law respond to the faith questions surrounding the cryonics patient? What am I? A block of ice. Who am I? A living, comatose patient or a dormant, static body with the possibility of a reverter. Why am I? A new human being now endowed with immortality through the triumph of life over death founded on man's current faith in the God called Technology. Cryonics through its unbalancing of the traditional triad of life poses formidable challenges to the major institutions of faith, health and justice. The practitioners in these institutions: clergy, physicians and lawyers must now reassess the rules of the game of life be they religious, medical or legal. This article offers insights to begin this reassessment. PMID:10263329

  20. Gamma irradiation as a phytosanitary treatment for fresh pome fruits produced in Patagonia

    NASA Astrophysics Data System (ADS)

    Pérez, J.; Lires, C.; Horak, C.; Pawlak, E.; Docters, A.; Kairiyama, E.

    2009-07-01

    Argentina produces 1.8 million tons/year of apples ( Malus domestica L.) and pears ( Pyrus communis L.) in the Patagonia region. Cydia pomonella, codling moth, and Grapholita molesta, Oriental fruit moth, ( Lepidoptera: Tortricidae) are quarantine pests in pome fruits. Irradiation is a promising phytosanitary treatment because a dose of 200 Gy completely prevents pest adult emergence. A pilot irradiation process of commercially packaged 'Red Delicious' apples and 'Packham's Triumph' pears was performed in an irradiation facility with a Cobalt 60 source. Quality analyses were carried out at 0, 2, 4, 6 and 8 months of storage (1 °C, RH 99%) to evaluate fruit tolerance at 200, 400 and 800 Gy. Irradiation at 200 and 400 Gy had no undesirable effects on fruit quality (pulp firmness, external colour, soluble solids content (SSC), titratable acidity (TA) and sensory evaluations). Irradiation of 'Red Delicious' apples and 'Packham's Triumph' pears can be applied as a commercial quarantine treatment with a minimum absorbed dose of 200 Gy (to control codling moth and Oriental fruit moth) and <800 Gy (according to quality results).

  1. Historical aspects of the early Soviet/Russian manned space program.

    PubMed

    West, J B

    2001-10-01

    Human spaceflight was one of the great physiological and engineering triumphs of the 20th century. Although the history of the United States manned space program is well known, the Soviet program was shrouded in secrecy until recently. Konstantin Edvardovich Tsiolkovsky (1857-1935) was an extraordinary Russian visionary who made remarkable predictions about space travel in the late 19th century. Sergei Pavlovich Korolev (1907-1966) was the brilliant "Chief Designer" who was responsible for many of the Soviet firsts, including the first artificial satellite and the first human being in space. The dramatic flight of Sputnik 1 was followed within a month by the launch of the dog Laika, the first living creature in space. Remarkably, the engineering work for this payload was all done in less than 4 wk. Korolev's greatest triumph was the flight of Yuri Alekseyevich Gagarin (1934-1968) on April 12, 1961. Another extraordinary feat was the first extravehicular activity by Aleksei Arkhipovich Leonov (1934-) using a flexible airlock that emphasized the entrepreneurial attitude of the Soviet engineers. By the mid-1960s, the Soviet program was overtaken by the United States program and attempts to launch a manned mission to the Moon failed. However, the early Soviet manned space program has a preeminent place in the history of space physiology.

  2. The reassembly of the body from parts: psychoanalytic reflections on death, resurrection, and cannibalism.

    PubMed

    Gottlieb, Richard M

    2007-01-01

    Terror of the dismemberment, disintegration, and decay of the body after death has been represented in ritual, myth, legend, art, and religious belief throughout the ages. So too has the wished-for triumph over these inevitable processes. Commonly, bodily experience after death is represented mentally in cannibalistic ideas of eating and being eaten, which are then countered by the wishful undoing of cannibalistic destruction through its reversal: swallowing as regurgitation, dismemberment as rememberment, disintegration as reassembly. Luca Signorelli's fresco The Resurrection of the Flesh is part of his celebrated group of decorations (1499-1504) of the Cappella Nuova in the cathedral at Orvieto. The doctrinal, iconographic, social, and political contexts of this admired and influential work are explored in order to illustrate how and why this painting represents our greatest fears, along with our triumph over them, as well as our most destructive urges and their reparative counterparts. The photographer Sally Mann has explored these same themes. In What Remains (2003), a series of pictures with accompanying text, Mann documents her exhumation and reassembly of the body of her beloved pet greyhound. Two clinical examples illustrate some ways these concerns (cannibalism and reassembly) may make their appearance in psychoanalytic work. PMID:18246760

  3. The iceperson cometh: cryonics, law and medicine.

    PubMed

    Smith, G P

    1983-01-01

    The "New Biology" has already made profound impact on the law. Cryonics and genetic engineering represent technological triumphs. The natural, organic process of dying is being replaced by a humanly engineered technological process for living. The dying phase of life is prolonged until biological knowledge is available to reverse the dying phase and restore the living phase. Both cryonics and genetic engineering in their attempts to replace the organic process with the technological process disturb the delicate balance of the triad of life which each individual experiences--faith, health, and justice. Since law is a basic tool to achieve justice among human beings, how should it respond to the health argument of the cryonics' physician who views death as a disease which is curable? How should the law respond to the faith questions surrounding the cryonics patient? What am I? A block of ice. Who am I? A living, comatose patient or a dormant, static body with the possibility of a reverter. Why am I? A new human being now endowed with immortality through the triumph of life over death founded on man's current faith in the God called Technology. Cryonics through its unbalancing of the traditional triad of life poses formidable challenges to the major institutions of faith, health and justice. The practitioners in these institutions: clergy, physicians and lawyers must now reassess the rules of the game of life be they religious, medical or legal. This article offers insights to begin this reassessment.

  4. Historical aspects of the early Soviet/Russian manned space program.

    PubMed

    West, J B

    2001-10-01

    Human spaceflight was one of the great physiological and engineering triumphs of the 20th century. Although the history of the United States manned space program is well known, the Soviet program was shrouded in secrecy until recently. Konstantin Edvardovich Tsiolkovsky (1857-1935) was an extraordinary Russian visionary who made remarkable predictions about space travel in the late 19th century. Sergei Pavlovich Korolev (1907-1966) was the brilliant "Chief Designer" who was responsible for many of the Soviet firsts, including the first artificial satellite and the first human being in space. The dramatic flight of Sputnik 1 was followed within a month by the launch of the dog Laika, the first living creature in space. Remarkably, the engineering work for this payload was all done in less than 4 wk. Korolev's greatest triumph was the flight of Yuri Alekseyevich Gagarin (1934-1968) on April 12, 1961. Another extraordinary feat was the first extravehicular activity by Aleksei Arkhipovich Leonov (1934-) using a flexible airlock that emphasized the entrepreneurial attitude of the Soviet engineers. By the mid-1960s, the Soviet program was overtaken by the United States program and attempts to launch a manned mission to the Moon failed. However, the early Soviet manned space program has a preeminent place in the history of space physiology. PMID:11568130

  5. Fifty years of hope and concern for the future of occupational medicine.

    PubMed

    Imbus, Harold R

    2004-02-01

    Recently, there has been considerable concern expressed from a number of sources about the future of occupational medicine. A review of the literature and other sources reveals that over the past 50 years there has been continuous hope and concern for the specialty. Occupational medicine became a certified specialty in 1955, growing slowly until 1970, when the passage of the Occupational Safety and Health Act, growth accelerated. The marked decrease in classic occupational diseases, injuries, and deaths is a major triumph but may also be a factor in declining interest in specialization by physicians. Potential conflicts of interest have been at issue for over 50 years. Occupational medicine is now mostly clinical, in contrast to previous years. However, occupational medicine is a distinct and solid specialty that still offers many challenges.

  6. Using 2nd generation tyrosine kinase inhibitors in frontline management of chronic phase chronic myeloid leukemia

    PubMed Central

    Jayakar, Vishal

    2014-01-01

    Choices in medicine come with responsibility. With several TKI's (Tyrosine kinase inhibitors) available for front-line management of CML (Chronic Myeloid Leukemia), an astute clinician has to personalise, rationalise and take a pragmatic approach towards selection of the best drug for the ‘patient in question’. Though it is hotly debated as to which TKI will triumph, the truth of this debate lies in individualising treatment rather than a general ‘all size fits all’ approach with imatinib. I personally believe that the second generation TKI's will suit most patient clinical profiles rather than prescribing imatinib to all and I have strived to make a strong case for them in front line treatment of CML. Though Imatinib may remain the first line choice for some patients, my efforts in this debate are mainly geared towards breaking the myth that imatinib is the sole ‘block buster’ on the CML landscape PMID:24665456

  7. Toward a Brighter Future for Psychology as an Observation Oriented Science

    PubMed Central

    Grice, James W.; Barrett, Paul T.; Schlimgen, Liz A.; Abramson, Charles I.

    2012-01-01

    Serious criticisms of psychology’s research practices and data analysis methods date back to at least the mid-1900s after the Galtonian school of thought had thoroughly triumphed over the Wundtian school. In the wake of Bem’s (2011) recent, highly publicized study on psi phenomena in a prestigious journal, psychologists are again raising serious questions about their dominant research script. These concerns are echoed in the current paper, and Observation Oriented Modeling (OOM) is presented as an alternative approach toward data conceptualization and analysis for the social and life sciences. This approach is rooted in philosophical realism and an attitude toward data analysis centered around causality and common sense. Three example studies and accompanying data analyses are presented and discussed to demonstrate a number of OOM’s advantages over current researcher practices. PMID:25379212

  8. Genetic modification of the human germ line: The reasons why this project has no future.

    PubMed

    Morange, Michel

    2015-01-01

    Modification of the human germ line has remained a distant but valuable objective for most biologists since the emergence of genetics (and even before). To study the historical transformations of this project, I have selected three periods - the 1930s, at the pinnacle of eugenics, around 1974 when molecular biology triumphed, and today - and have adopted three criteria to estimate the feasibility of this project: the state of scientific knowledge, the existence of suitable tools, and societal demands. Although the long-awaited techniques to modify the germ line are now available, I will show that most of the expectations behind this project have disappeared, or are considered as being reachable by highly different strategies.

  9. Of mice and men: an introduction to mouseology or, anal eroticism and Disney.

    PubMed

    Berger, A A

    1991-01-01

    This essay deals with two important comics, Walt Disney's Mickey Mouse and George Herriman's Krazy Kat, and considers the social, cultural, psychological and symbolic significance of the main characters and their creators. In the discussion of Disney and his work (based, in part on writings about him) it is suggested that he exhibited traits associated with anal eroticism, which raises an interesting question about the popularity of his work with the American public. The two dominant themes found in Krazy Kat are described as "the triumph of illusion over reality" and "anti-authoritarianism." In a comparison of the two characters, it is shown they are polar opposites: Mickey Mouse is sadistic, asexual, and anal while Ignatz Mouse, the hero of Krazy Kat, is playful, sexual, and phallic.

  10. Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

    PubMed

    Livingstone, David N

    2015-09-01

    Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

  11. Unveiling Cancer

    PubMed Central

    Lakhtakia, Ritu; Burney, Ikram; Qureshi, Asim; Al-Azawi, Sinan; Al-Badi, Hamid; Al-Hajri, Shaikha

    2015-01-01

    This article narrates a multifaceted educational journey undertaken by a medical student through a weekly SCRAPS (surgery, clinical disciplines, radiology, anatomy, psychiatry and laboratory sciences) clinico-pathological meeting held in the College of Medicine & Health Sciences at Sultan Qaboos University in Muscat, Oman. Through a presentation titled ‘Unveiling Cancer’, the multidisciplinary and interprofessional audience witnessed a simulated interaction between a medical student, a technologist peer and tutors in medicine, pathology and radiology. The presentation was based on the complexities of presentation, diagnosis and management of a patient with anaplastic large cell lymphoma, a rare type of non-Hodgkin lymphoma, in the aftermath of a bone marrow transplantation. After describing the case, the student shared with the audience a spectrum of learning objectives, which included integration in the complex world of contemporary medicine, insight into the triumphs and travails of technology (immunohistochemistry) and peer collaboration, communication and mentorship. PMID:26355844

  12. Seeing the oceans in the shadow of Bergen values.

    PubMed

    Hamblin, Jacob Darwin

    2014-06-01

    Although oceanographers such as Roger Revelle are typically associated with key indicators of anthropogenic change, he and other scientists at midcentury had very different scientific priorities and ways of seeing the oceans. How can we join the narrative of the triumph of mathematical, dynamic oceanography with the environmental narrative? Dynamic methods entailed a broad set of values that touched the professional lives of marine scientists in a variety of disciplines all over the world, for better or for worse. The present essay highlights three aspects of "Bergen values" in need of greater exploration by scholars. First, how did the dominance of Scandinavian outlooks influence scientific questions across the broad spectrum of oceanography? Second, did oceanographers' particular means of making the oceans legible through instrumentation challenge their ability to perceive the oceans differently? Third, given the immense quantity of data, was the historical legacy of the dynamic oceanographers more descriptive than they imagined?

  13. Barriers to cross--institutional health information exchange: a literature review.

    PubMed

    Edwards, Ashley; Hollin, Ilene; Barry, Jeffrey; Kachnowski, Stan

    2010-01-01

    While the development of health information technology, particularly electronic health records (EHR), is a triumph for the advancement of healthcare, non-interoperable clinical data systems lead to fragmented communication and incomplete records. If interoperable HIT systems could be achieved integrated HIT could be leveraged to lessen medical errors, improve patient care and optimize epidemiological research. To understand the barriers to interoperability or health information exchange (HIE), we reviewed the literature on HIT and barriers to HIE. Our search yielded 492 articles, 25 meeting our inclusion criteria. In general, we found that the predominant barriers to HIE are need for standards, security concerns, economic loss to competitors, and federated systems. Research on interoperability is limited because most HIE programs are still in formative stages. More research is needed to fully understand interoperability of HIT, how to overcome the barriers to interoperability, and how to design HIT to better facilitate HIE.

  14. Filling-enforced quantum band insulators in spin-orbit coupled crystals.

    PubMed

    Po, Hoi Chun; Watanabe, Haruki; Zaletel, Michael P; Vishwanath, Ashvin

    2016-04-01

    An early triumph of quantum mechanics was the explanation of metallic and insulating behavior based on the filling of electronic bands. A complementary, classical picture of insulators depicts electrons as occupying localized and symmetric Wannier orbitals that resemble atomic orbitals. We report the theoretical discovery of band insulators for which electron filling forbids such an atomic description. We refer to them as filling-enforced quantum band insulators (feQBIs) because their wave functions are associated with an essential degree of quantum entanglement. Like topological insulators, which also do not admit an atomic description, feQBIs need spin-orbit coupling for their realization. However, they do not necessarily support gapless surface states. Instead, the band topology is reflected in the insulating behavior at an unconventional filling. We present tight binding models of feQBIs and show that they only occur in certain nonsymmorphic, body-centered cubic crystals. PMID:27152352

  15. Resilience and human adaptability: who rises above adversity? 1990 Eleanor Clarke Slagle Lecture.

    PubMed

    Fine, S B

    1991-06-01

    We work in a world of traumas and triumphs. Most of the persons we serve come to us out of necessity, struggling with the sequelae of disease and illness or the aftermath of natural or manmade disasters. We bring our expertise and compassion; they bring their bodies, minds, and compromised lives. Our worlds converge around a shared task; identifying and enhancing their capacities for daily living. We pursue problems of movement, perception, cognition, affect, and social capacity within the context of their roles and aspirations. Our contacts may be extensive, but often they are brief and only partially fulfilled. Our patients move on with varying degrees of functional ability--some with determination and buoyancy, others with little confidence that life is actually worth living. We remain, frequently knowing little about the factors that have influenced the outcome of our efforts. In spite of their compelling importance to our patients, our professional viability, and the health care system.

  16. A Personal Reflection on the History of Radiation Oncology at Memorial Sloan-Kettering Cancer Center

    SciTech Connect

    Chu, Florence C.H.

    2011-07-01

    Purpose: To provide a historical and personal narrative of the development of radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC), from its founding more than 100 years ago to the present day. Methods and Materials: Historical sources include the Archives of MSKCC, publications by members of MSKCC, the author's personal records and recollections, and her communications with former colleagues, particularly Dr. Basil Hilaris, Dr. Zvi Fuks, and Dr. Beryl McCormick. Conclusions: The author, who spent 38 years at MSKCC, presents the challenges and triumphs of MSKCC's Radiation Oncology Department and details MSKCC's breakthroughs in radiation oncology. She also describes MSKCC's involvement in the founding of the American Society for Therapeutic Radiology and Oncology.

  17. "The foolmaster who fooled them".

    PubMed Central

    Young, J. H.

    1980-01-01

    Throughout the nineteenth century, physicians assumed the major task of analyzing and warning against quackery and unorthodoxy. The nature of this criticism is described, with key reliance on Worthington Hooker's Lessons from the History of Medical Delusions (1850). Most physicians viewed prospects for suppressing quackery more hopefully than Hooker did. Even he, however, would be shocked that delusion could persist so stubbornly despite advancing medical science, expanding education, and increasing regulation. Many factors help explain today's continuing-even burgeoning-quackery. These include a less cheerful view of both human nature and of the future, widespread skepticism about the fruits for science, impatience with governmental regulation, the vogue for self-help in health, increasing promotional sophistication on the part of unorthodox health vendors, and cooperation among various wings of unorthodoxy to maximize political pressure. Examples are given. Champions of alternative therapies predict their triumph over orthodox medical science in the contest being waged for the allegiance of the public. PMID:7018095

  18. Animal models for HIV/AIDS research.

    PubMed

    Hatziioannou, Theodora; Evans, David T

    2012-12-01

    The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection.

  19. Mathemimetics II. Demonstratio Mirabilis of FLT by infinitely ascending cubical crystal growth

    NASA Astrophysics Data System (ADS)

    Trell, Erik

    2012-09-01

    Emulating Nature by observation and ground-up application of its patterns, structures and processes is a classical scientific practice which under the designation of Biomimetics has now been brought to the Nanotechnology scale where even highly complex systems can be realized by continuous or cyclically reiterated assembly of the respective self-similar eigen-elements, modules and algorithms right from their infinitesimal origin. This is actually quite akin to the genuine mathematical art and can find valuable renewed use as here exemplified by the tentatively original Demonstratio Mirabilis of FLT (Fermat's Last Theorem, or, in that case, Triumph) by infinitely ascending sheet-wise cubical crystal growth leading to the binomial `magic triangle' of his close fellow Blaise Pascal.

  20. Progress in reforming chemical engineering education.

    PubMed

    Wankat, Phillip C

    2013-01-01

    Three successful historical reforms of chemical engineering education were the triumph of chemical engineering over industrial chemistry, the engineering science revolution, and Engineering Criteria 2000. Current attempts to change teaching methods have relied heavily on dissemination of the results of engineering-education research that show superior student learning with active learning methods. Although slow dissemination of education research results is probably a contributing cause to the slowness of reform, two other causes are likely much more significant. First, teaching is the primary interest of only approximately one-half of engineering faculty. Second, the vast majority of engineering faculty have no training in teaching, but trained professors are on average better teachers. Significant progress in reform will occur if organizations with leverage-National Science Foundation, through CAREER grants, and the Engineering Accreditation Commission of ABET-use that leverage to require faculty to be trained in pedagogy.

  1. Finding the Lost City

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Nicholas Clapp, a filmmaker and archeology enthusiast, had accumulated extensive information concerning Ubar, the fabled lost city of ancient Arabia. When he was unable to identify its exact location, however, he turned to the Jet Propulsion Laboratory (JPL) for assistance in applying orbital remote sensing techniques. JPL scientists searched NASA's shuttle imaging radar, as well as Landsat and SPOT images and discovered ancient caravan tracks. This enabled them to prepare a map of the trails, which converged at a place known as Ash Shisr. An expedition was formed, which found structures and artifacts from a city that predates previous area civilization by a thousand years. Although it will take time to validate the city as Ubar, the discovery is a monumental archeological triumph.

  2. Say What? The Role of Audio in Multimedia Video

    NASA Astrophysics Data System (ADS)

    Linder, C. A.; Holmes, R. M.

    2011-12-01

    Audio, including interviews, ambient sounds, and music, is a critical-yet often overlooked-part of an effective multimedia video. In February 2010, Linder joined scientists working on the Global Rivers Observatory Project for two weeks of intensive fieldwork in the Congo River watershed. The team's goal was to learn more about how climate change and deforestation are impacting the river system and coastal ocean. Using stills and video shot with a lightweight digital SLR outfit and audio recorded with a pocket-sized sound recorder, Linder documented the trials and triumphs of working in the heart of Africa. Using excerpts from the six-minute Congo multimedia video, this presentation will illustrate how to record and edit an engaging audio track. Topics include interview technique, collecting ambient sounds, choosing and using music, and editing it all together to educate and entertain the viewer.

  3. Robot Design

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Martin Marietta Aero and Naval Systems has advanced the CAD art to a very high level at its Robotics Laboratory. One of the company's major projects is construction of a huge Field Material Handling Robot for the Army's Human Engineering Lab. Design of FMR, intended to move heavy and dangerous material such as ammunition, was a triumph in CAD Engineering. Separate computer problems modeled the robot's kinematics and dynamics, yielding such parameters as the strength of materials required for each component, the length of the arms, their degree of freedom and power of hydraulic system needed. The Robotics Lab went a step further and added data enabling computer simulation and animation of the robot's total operational capability under various loading and unloading conditions. NASA computer program (IAC), integrated Analysis Capability Engineering Database was used. Program contains a series of modules that can stand alone or be integrated with data from sensors or software tools.

  4. Uncertain for a century: quantum mechanics and the dilemma of interpretation.

    PubMed

    Frank, Adam

    2015-12-01

    Quantum mechanics, the physical theory describing the microworld, is one of science's greatest triumphs. Remarkably, however, after more than 100 years it is still unclear what quantum mechanics means in terms of basic philosophical questions about the nature of reality. While there are many interpretations of the mathematical machinery of quantum physics, there remain no experimental means to distinguish between most of them. In this contribution, I wish to consider the ways in which the enduring lack of an agreed-upon interpretation of quantum physics influences a number of critical philosophical debates about physics and reality. I briefly review two problems affected by quantum interpretations: the meaning of the term universe and the nature of consciousness.

  5. Gravitational Lensing

    ScienceCinema

    Lincoln, Don

    2016-07-12

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  6. Smallpox vaccines: targets of protective immunity.

    PubMed

    Moss, Bernard

    2011-01-01

    The eradication of smallpox, one of the great triumphs of medicine, was accomplished through the prophylactic administration of live vaccinia virus, a comparatively benign relative of variola virus, the causative agent of smallpox. Nevertheless, recent fears that variola virus may be used as a biological weapon together with the present susceptibility of unimmunized populations have spurred the development of new-generation vaccines that are safer than the original and can be produced by modern methods. Predicting the efficacy of such vaccines in the absence of human smallpox, however, depends on understanding the correlates of protection. This review outlines the biology of poxviruses with particular relevance to vaccine development, describes protein targets of humoral and cellular immunity, compares animal models of orthopoxvirus disease with human smallpox, and considers the status of second- and third-generation smallpox vaccines.

  7. There is grandeur in this view of Newton: Charles Darwin, Isaac Newton and Victorian conceptions of scientific virtue.

    PubMed

    Bellon, Richard

    2014-01-01

    For Victorian men of science, the scientific revolution of the seventeenth century represented a moral awakening. Great theoretical triumphs of inductive science flowed directly from a philosophical spirit that embraced the virtues of self-discipline, courage, patience and humility. Isaac Newton exemplified this union of moral and intellectual excellence. This, at least, was the story crafted by scientific leaders like David Brewster, Thomas Chalmers, John Herschel, Adam Sedgwick and William Whewell. Not everyone accepted this reading of history. Evangelicals who decried the 'materialism' of mainstream science assigned a different meaning to Newton's legacy on behalf of their 'scriptural' alternative. High-church critics of science like John Henry Newman, on the other hand, denied that Newton's secular achievements carried any moral significance at all. These debates over Newtonian standards of philosophical behavior had a decisive influence on Charles Darwin as he developed his theory of evolution by natural selection. PMID:25455541

  8. Promoting Physics Among Female Learners in the Western Cape Through Active Engagement (abstract)

    NASA Astrophysics Data System (ADS)

    Arendse, Gillian J.

    2009-04-01

    In 2006 the author organized a one-day intervention aimed at promoting physics among female learners at the University of Stellenbosch. The activities included an interactive lecture demonstration promoting active engagement, a hands-on session, and short presentations by female physicists addressing issues such as balancing family and career, breaking the stereotypes, and launching a successful career in physics. Each learner was expected to evaluate the program. In 2007 the author joined forces with Hip2B2 (Shuttleworth Foundation) to host a competition among grade-10 learners with the theme, ``promoting creativity through interactivity.'' The author was tasked by the Hip2B2-team to assist with a program for female learners planned for August 2008, coinciding with our national celebration of Women's Day. The event targeted 160 learners and took place in Durban, East London, Cape Town, and Johannesburg. The author shares some of the learners' experiences and personal triumphs.

  9. Ships at a distance: Energy choice and economic challenge

    SciTech Connect

    Bradford, P.A.

    1997-12-31

    Several restructurings of Vermont`s electric utilities were attempted earlier. At best, the successes were compromises, whose benefits were a fraction of what might have been achieved. At worst, monopoly power triumphed outright, leaving Vermonters and Vermont economy in thrall to distant energy and financial forces. To understand the interplay between today`s restructuring and the Vermont economy, the author examines those earlier restructuring. They establish that electricity really is different from other industries, not just because it cannot be stored or because the strandable investment is so much larger or the monopoly linkages are so much more extensive. More important is the extent of the electric industry`s place in the national political consciousness and its environmental impact.

  10. Werner Heisenberg (1901-1976)

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Werner Heisenberg was one of the greatest physicists of all times. When he started out as a young research worker, the world of physics was in a very confused and frustrating state, which Abraham Pais has described1 as: It was the spring of hope, it was the winter of despair using Charles Dickens' words in A Tale of Two Cities. People were playing a guessing game: There were from time to time great triumphs in proposing, through sheer intuition, make-shift schemes that amazingly explained some regularities in spectral physics, leading to joy. But invariably such successes would be followed by further work which reveal the inconsistency or inadequacy of the new scheme, leading to despair...

  11. Progress in reforming chemical engineering education.

    PubMed

    Wankat, Phillip C

    2013-01-01

    Three successful historical reforms of chemical engineering education were the triumph of chemical engineering over industrial chemistry, the engineering science revolution, and Engineering Criteria 2000. Current attempts to change teaching methods have relied heavily on dissemination of the results of engineering-education research that show superior student learning with active learning methods. Although slow dissemination of education research results is probably a contributing cause to the slowness of reform, two other causes are likely much more significant. First, teaching is the primary interest of only approximately one-half of engineering faculty. Second, the vast majority of engineering faculty have no training in teaching, but trained professors are on average better teachers. Significant progress in reform will occur if organizations with leverage-National Science Foundation, through CAREER grants, and the Engineering Accreditation Commission of ABET-use that leverage to require faculty to be trained in pedagogy. PMID:23394171

  12. Ancient Chinese medical ethics and the four principles of biomedical ethics.

    PubMed

    Tsai, D F

    1999-08-01

    The four principles approach to biomedical ethics (4PBE) has, since the 1970s, been increasingly developed as a universal bioethics method. Despite its wide acceptance and popularity, the 4PBE has received many challenges to its cross-cultural plausibility. This paper first specifies the principles and characteristics of ancient Chinese medical ethics (ACME), then makes a comparison between ACME and the 4PBE with a view to testing out the 4PBE's cross-cultural plausibility when applied to one particular but very extensive and prominent cultural context. The result shows that the concepts of respect for autonomy, non-maleficence, beneficence and justice are clearly identifiable in ACME. Yet, being influenced by certain socio-cultural factors, those applying the 4PBE in Chinese society may tend to adopt a "beneficence-oriented", rather than an "autonomy-oriented" approach, which, in general, is dissimilar to the practice of contemporary Western bioethics, where "autonomy often triumphs".

  13. [The Best Interest of the Child in Neonatology: Is It Best for the Child?].

    PubMed

    González-Melado, Fermín J; Di Pietro, María Luisa

    2015-01-01

    Since its inceptions, the standard of best interest of the child was linked to decisions about suspend life-sustaining treatments in neonatal units and evaluation of treatments applied to children in terms of their quality of life. This origin has conditioned the interpretation of the standard from two extremes: a vitalistic one, and a non vitalistic interpretation that triumphed in Western bioethics and has led to the consecration of the standard of best interest of the child in the Convention on the Rights of the Child of United Nations. A detailed analysis reveals a simplistic, utilitarian and proportionalist standard, which change the basis of parenthood. We therefore believe that the standard of the best interest of the child is not the best for the child in neonatal intensive care units and especially not in the process of withhold or withdrawal life-sustaining treatments. PMID:26378595

  14. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    NASA Astrophysics Data System (ADS)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  15. Julius Wagner-Jauregg and the Legacy of Malarial Therapy for the Treatment of General Paresis of the Insane

    PubMed Central

    Tsay, Cynthia J.

    2013-01-01

    Julius Wagner-Jauregg, a preeminent Austrian psychiatrist was awarded the Nobel Prize in Medicine in 1927 for the development of malaria therapy for the treatment of neurosyphilis, or general paresis of the insane. Despite being only one of three psychiatrists to win a Nobel Prize, he has faded from public consciousness and his name recognition pales in comparison to his contemporary and fellow Austrian, Sigmund Freud. This paper explores his contributions to the field of biological psychiatry and also touches upon reasons, such as the growing bioethics movement, his controversial affiliation with the Nazi Party, and the evolution of neurosyphilis, that explain why Wagner-Jauregg is not more widely celebrated for his contributions to the field of psychiatry, even though his malarial treatment could be considered the earliest triumph of biological psychiatry over psychoanalysis. PMID:23766744

  16. Of mice and men: an introduction to mouseology or, anal eroticism and Disney.

    PubMed

    Berger, A A

    1991-01-01

    This essay deals with two important comics, Walt Disney's Mickey Mouse and George Herriman's Krazy Kat, and considers the social, cultural, psychological and symbolic significance of the main characters and their creators. In the discussion of Disney and his work (based, in part on writings about him) it is suggested that he exhibited traits associated with anal eroticism, which raises an interesting question about the popularity of his work with the American public. The two dominant themes found in Krazy Kat are described as "the triumph of illusion over reality" and "anti-authoritarianism." In a comparison of the two characters, it is shown they are polar opposites: Mickey Mouse is sadistic, asexual, and anal while Ignatz Mouse, the hero of Krazy Kat, is playful, sexual, and phallic. PMID:1856466

  17. Small(pox) success?

    PubMed

    Birn, Anne-Emanuelle

    2011-02-01

    The 30th anniversary of the World Health Organization's (WHO) official certification of smallpox eradication was marked by a slew of events hailing the campaign's dramatic tale of technological and organizational triumph against an ancient scourge. Yet commemorations also serve as moments of critical reflection. This article questions the acclaim showered upon smallpox eradication as the single greatest public health success in history. It examines how and why smallpox eradication and WHO's concurrent social justice-oriented primary health care approach (following from the Declaration of Alma-Ata) became competing paradigms. It synthesizes critiques of eradication's shortcomings and debunks some of the myths surrounding the global eradication campaign as a public health priority and necessity, and as a Cold War victory of cooperation. The article concludes with thoughts on integrating technical and social-political aspects of health within the context of welfare states as the means to achieving widespread and enduring global public health success.

  18. A forgotten social science? Creating a place for linguistics in the historical dialogue.

    PubMed

    Martin-Nielsen, Janet

    2011-01-01

    The post-World War II era was one of great triumph for American linguists-and yet linguistics is all but absent from the historical literature on postwar social science. This paper aims to illuminate this curious situation: to understand its provenance, evaluate its merits, and contextualize it broadly. I argue that the historiographic lacuna results from two factors: (1) the opt-out of linguists from the wider American social science community, and (2) historical-developmental and -orientational factors that stand linguistics apart from the social science mainstream. The resultant isolation of linguistics has led to a parallel isolation in the historical literature. Ultimately, this paper poses a pivotal and timely question: How is the postwar social science space construed within the existing historiographic framework, and how should it be construed in order to maximize understanding? I propose a rethink of the received historiography centered on intellectual transformations and cross-disciplinary integration.

  19. Arctic and Antarctic exploration including the contributions of physicians and effects of disease in the polar regions.

    PubMed

    Fodstad, H; Kondziolka, D; Brophy, B P; Roberts, D W; Girvin, J P

    1999-05-01

    A history of Arctic and Antarctic exploration, whether to find a Northwest Passage, North Pole, or South Pole, is a story of triumph and tribulation. The hardship experienced by polar explorers in the last 1000 years permeates the tales of achievement. Physicians and surgeons have played prominent roles in all major polar explorations. No significant Arctic voyage, particularly in the last 300 years, was made without a member of the party trained in the management of medical emergencies and in basic surgery. During times of health, surgeons functioned as the voyage naturalists with expertise in biology, botany, zoology, and the writing of scientific catalogs. Spurred by our interest and fascination with the history of polar exploration, we reviewed the roles of physicians and natural scientists in Arctic and Antarctic adventures. PMID:10232525

  20. Arctic and Antarctic exploration including the contributions of physicians and effects of disease in the polar regions.

    PubMed

    Fodstad, H; Kondziolka, D; Brophy, B P; Roberts, D W; Girvin, J P

    1999-05-01

    A history of Arctic and Antarctic exploration, whether to find a Northwest Passage, North Pole, or South Pole, is a story of triumph and tribulation. The hardship experienced by polar explorers in the last 1000 years permeates the tales of achievement. Physicians and surgeons have played prominent roles in all major polar explorations. No significant Arctic voyage, particularly in the last 300 years, was made without a member of the party trained in the management of medical emergencies and in basic surgery. During times of health, surgeons functioned as the voyage naturalists with expertise in biology, botany, zoology, and the writing of scientific catalogs. Spurred by our interest and fascination with the history of polar exploration, we reviewed the roles of physicians and natural scientists in Arctic and Antarctic adventures.

  1. Gravitational Lensing

    SciTech Connect

    Lincoln, Don

    2015-06-24

    In a long line of intellectual triumphs, Einstein’s theory of general relativity was his greatest and most imaginative. It tells us that what we experience as gravity can be most accurately described as the bending of space itself. This idea leads to consequences, including gravitational lensing, which is caused by light traveling in this curved space. This is works in a way analogous to a lens (and hence the name). In this video, Fermilab’s Dr. Don Lincoln explains a little general relativity, a little gravitational lensing, and tells us how this phenomenon allows us to map out the matter of the entire universe, including the otherwise-invisible dark matter.

  2. Filling-enforced quantum band insulators in spin-orbit coupled crystals

    PubMed Central

    Po, Hoi Chun; Watanabe, Haruki; Zaletel, Michael P.; Vishwanath, Ashvin

    2016-01-01

    An early triumph of quantum mechanics was the explanation of metallic and insulating behavior based on the filling of electronic bands. A complementary, classical picture of insulators depicts electrons as occupying localized and symmetric Wannier orbitals that resemble atomic orbitals. We report the theoretical discovery of band insulators for which electron filling forbids such an atomic description. We refer to them as filling-enforced quantum band insulators (feQBIs) because their wave functions are associated with an essential degree of quantum entanglement. Like topological insulators, which also do not admit an atomic description, feQBIs need spin-orbit coupling for their realization. However, they do not necessarily support gapless surface states. Instead, the band topology is reflected in the insulating behavior at an unconventional filling. We present tight binding models of feQBIs and show that they only occur in certain nonsymmorphic, body-centered cubic crystals. PMID:27152352

  3. The Continuous Confrontation of Caregiving as Described in Real-Time Online Group Chat.

    PubMed

    Male, Dana A; Fergus, Karen D; Stephen, Joanne E

    2015-01-01

    To date, our understanding of the caregiver experience has been informed primarily by guided inquiry in the form of interviews and surveys, yielding information that is limited by the scope of researchers questions. The intent of this study was to explore the experience of caring for a loved one with advanced-stage cancer by means of participant-determined communication, using interactive, text-based transcripts from synchronous online support groups. Grounded theory analysis of the group transcripts yielded the core category continuous confrontation, characterized by major challenges (unrelenting assault, a new us, and the costs of caregiving) and minor triumphs (refuelling and living more intentionally). This unique method of data collection allowed for an especially candid, intersubjective group account of what it is to be a caregiver for an ill loved one without compromising the details that caregivers themselves consider important.

  4. Clinical vaccine development

    PubMed Central

    2015-01-01

    Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge and the investment of massive funding have enabled the development of vaccines against many infectious diseases as well as other diseases including malignant tumors. The paradigm of clinical vaccine evaluation and licensure has also been modernized based on scientific improvements and historical experience. However, there remain a number of hurdles to overcome. Continuous efforts are focused on increasing the efficacy and reducing the risks related to vaccine use. Cutting-edge knowledge about immunology and microbiology is being rapidly translated to vaccine development. Thus, physicians and others involved in the clinical development of vaccines should have sufficient understanding of the recent developmental trends in vaccination and the diseases of interest. PMID:25648742

  5. Genetic modification of the human germ line: The reasons why this project has no future.

    PubMed

    Morange, Michel

    2015-01-01

    Modification of the human germ line has remained a distant but valuable objective for most biologists since the emergence of genetics (and even before). To study the historical transformations of this project, I have selected three periods - the 1930s, at the pinnacle of eugenics, around 1974 when molecular biology triumphed, and today - and have adopted three criteria to estimate the feasibility of this project: the state of scientific knowledge, the existence of suitable tools, and societal demands. Although the long-awaited techniques to modify the germ line are now available, I will show that most of the expectations behind this project have disappeared, or are considered as being reachable by highly different strategies. PMID:26231145

  6. Laser Ranging to the Moon: How Evolving Technology Enables New Science

    NASA Astrophysics Data System (ADS)

    Faller, James

    2010-03-01

    Technological advances have long been the enabler of scientific progress. The invention of the laser is a prime example of this symbiotic relationship between technical progress and scientific advances. The laser, which today is omnipresent in each of our lives, made its first appearance during the time that I was a graduate student in Professor Dicke's group at Princeton. A major change occurring during that time period was that technology was transforming the study of gravitational physics from just a theoretical subject into also an experimental subject where one could hope to measure things using by-then-available laboratory technologies and techniques. During this same time, the idea for the lunar laser ranging experiment was born. The history and accomplishments of this experiment--a still ongoing experiment which is one of the real scientific triumphs of NASA's Apollo program--will be given.

  7. Competition of individual and institutional punishments in spatial public goods games

    NASA Astrophysics Data System (ADS)

    Szolnoki, Attila; Szabó, György; Czakó, Lilla

    2011-10-01

    We have studied the evolution of strategies in spatial public goods games where both individual (peer) and institutional (pool) punishments are present in addition to unconditional defector and cooperator strategies. The evolution of strategy distribution is governed by imitation based on the random sequential comparison of neighbors’ payoff for a fixed level of noise. Using numerical simulations, we evaluate the strategy frequencies and phase diagrams when varying the synergy factor, punishment cost, and fine. Our attention is focused on two extreme cases describing all the relevant behaviors in such a complex system. According to our numerical data peer punishers prevail and control the system behavior in a large segments of parameters while pool punishers can only survive in the limit of weak peer punishment when a rich variety of solutions is observed. Paradoxically, the two types of punishment may extinguish each other’s impact, resulting in the triumph of defectors. The technical difficulties and suggested methods are briefly discussed.

  8. Update in Cancer Chemotherapy: Genitourinary Tract Cancer, Part 1

    PubMed Central

    Wright, Jane C.

    1987-01-01

    An update of the state of the art of cancer chemotherapeutic treatment of genitourinary tract cancer is described in this multi-part series. Included in the review are cancers of the kidney, bladder, prostate, testicle, ovary, uterus, vulva, and gestational trophoblastic neoplasms. Part 1 focuses on the kidney. In this heterogeneous group of tumors, the major triumphs of cancer chemotherapy are in the control of the less common of these tumors, namely, gestational trophoblastic neoplasms in women, in combination with surgery in the control of the embryonal cell cancer of the testis in men, and in combination with surgery and radiation therapy in the control of the Wilms' tumor in children. Important progress is being made in the control of the other tumors of the genitourinary tract with the use of cancer chemotherapy. PMID:3323538

  9. New experimental results on cosmic gravitational effects and the centenary of Einstein's equation

    NASA Astrophysics Data System (ADS)

    Unnikrishnan, C. S.

    As one celebrates the centennial triumph of the general theory of relativity (GTR), Einstein's theory of gravity, it is appropriate to review and assess the experimental foundations of the theory in the context of what we know about matter in the universe, a knowledge that did not exist when GTR was formulated. A worldview consistent with and rigorously based on experimental evidence indeed demands a paradigm change and theoretical revision. The new theory of dynamics and relativity is Cosmic Relativity, with both absolute space and absolute time of a preferred cosmic frame, and it implies a modified GTR on its new and deeper foundation. Supporting results from laboratory experiments on the relative one-way velocity of light and the direct gravitational action of the cosmic matter on dynamics are discussed, demanding a modified equation of relativistic gravitation, aptly called the Centenary Einstein's equation.

  10. [Nicanor Rojas, dean of the School of Medicine during Balmaceda's dictatorship].

    PubMed

    Costa-Casaretto, C

    1995-07-01

    The Chilean President José Manuel Balmaceda (1886-1891) had a constitutional conflict with the parliament. This conflict lead to a revolution that ended with the President's suicide, when he was refuged at the Argentinian Embassy in September 1891. President Balmaceda conducted an authoritarian government during several months. A decree from February, 1897, disposed the reorganization of the Medical School, dismissed and imprisoned the Dean, Dr Barros-Borgoño and nominated new Professors. Dr Nicanor Rojas, Professor of Gynecology was assigned as Dean and Dr Carlos Sazié as secretary. During the During the war against Perú and Bolivia, Dr. Rojas worked gratuitously and became prominent, being named Chief Surgeon of the Chilean Army. After the triumph of the revolution against President Balmaceda, Dr Rojas was discharged, and died in 1892. PMID:8560126

  11. Charles Augustin Coulomb and the fundamental law of electrostatics

    NASA Astrophysics Data System (ADS)

    Falconer, Isobel

    2004-10-01

    In his famous experiment on the inverse square law of electrostatics, Coulomb neither defined electric charge nor gave reliable measurements of the force-distance relation. Yet the experiment has often been viewed as the basis of the fundamental law of electrostatics. This paper discusses Coulomb's life, showing the context within which he was working, how he arrived at the experiment, and the use he made of it. Physics in France in the late 18th century was undergoing a transformation from a science of holistic observation and explanations to one of universal laws and exact measurement. Coulomb was both a subject of, and an important contributor to, this change, and these two aspects are evident in his approach to the experiment and to the later uptake of his results. The reaction in the rest of Europe was initially less favourable, and the ultimate fame of Coulomb's experiment was dependent on the triumph of French mathematical physics in the 19th century.

  12. SSc and the 2013 diagnostic criteria: the case of Paul Klee's manual pathology and dysgraphia.

    PubMed

    Weisz, G M; Albury, W R; Matucci-Cerinic, M

    2014-11-01

    The German-Swiss modernist painter Paul Klee (1879-1940) suffered in the final years of his life from a severe illness, diagnosed in 1936 as scleroderma, later renamed SSc. New classification criteria for this disease issued in 2013 now allow for a diagnosis to be confirmed. Important for this process, however, is the question of whether or not Klee's hands were affected by his illness. The morphology of the artist's hands and evidence of dysgraphic changes in his handwriting are reviewed as indications of his manual pathology. Despite his illness, Klee triumphed over his infirmity, simplifying his painting and drawing styles and substantially increasing his artistic output from 1936 until his death in 1940. PMID:25236296

  13. Ancient Chinese medical ethics and the four principles of biomedical ethics.

    PubMed Central

    Tsai, D F

    1999-01-01

    The four principles approach to biomedical ethics (4PBE) has, since the 1970s, been increasingly developed as a universal bioethics method. Despite its wide acceptance and popularity, the 4PBE has received many challenges to its cross-cultural plausibility. This paper first specifies the principles and characteristics of ancient Chinese medical ethics (ACME), then makes a comparison between ACME and the 4PBE with a view to testing out the 4PBE's cross-cultural plausibility when applied to one particular but very extensive and prominent cultural context. The result shows that the concepts of respect for autonomy, non-maleficence, beneficence and justice are clearly identifiable in ACME. Yet, being influenced by certain socio-cultural factors, those applying the 4PBE in Chinese society may tend to adopt a "beneficence-oriented", rather than an "autonomy-oriented" approach, which, in general, is dissimilar to the practice of contemporary Western bioethics, where "autonomy often triumphs". PMID:10461594

  14. The achievements of William Crawford Gorgas.

    PubMed

    Craddock, W L

    1997-05-01

    From an obscure frontier surgeon George Crawford Gorgas became internationally acclaimed as a preventive medicine genius. By his initiative in translating the known scientific facts made possible during the blossoming of bacteriology, he performed service not only in the United States but in Cuba, Central and South America, South Africa, and Eastern Europe. He fought for 10 years successfully against yellow fever, malaria, and other diseases during the construction of the Panama Canal, and continued triumphs against disease in other world situations. This is a rather concise account emphasizing his continued devotion and dedication as a humanitarian. He fashioned the Army Medical Department into an efficient machine as Surgeon General, and following his amazing military career of over 38 years, made further contributions in preventive medicine with the Rockefeller Foundation. PMID:9155101

  15. [Iron ore, economic geology and networks of experts between Wisconsin and the state of Minas Gerais, 1881-1914].

    PubMed

    Fischer, Georg

    2014-01-01

    This article deals with the "discovery" of Brazilian iron ore from two perspectives. The first examines the increasing emphasis of the geosciences and their practical application and global reach since the second half of the nineteenth century. While in Brazil economic geology was integrated step by step into state institutions, at the global level it experienced its moment of triumph with the 11th International Geological Congress in 1910. The second deals with a specific social network with a decisive role in the race for Brazilian iron ore: with transnational experts juggling between the logic of the market and that of the academy. The article reveals the importance of local negotiations in the incorporation of the subsoil of Minas Gerais into the global space of mining. PMID:24554136

  16. Richard Feynman and the History of Superconductivity

    NASA Astrophysics Data System (ADS)

    Goodstein, David; Goodstein, Judith

    This paper deals with two topics. One is the history of superconductivity, and the other is what Richard Feynman had to do with it. The history of superconductivity can be traced back to Michael Faraday and the first liquefaction of a gas in 1823. It is a heroic tale of triumph over cold and resistance, and once the phenomenon was actually discovered in 1911, it would take almost 50 years more before a satisfactory explanation emerged. Although Richard Feynman only authored one published paper on the subject, he worked prodigiously on the problem through much of the 1950s, and his competitors, particularly Bardeen, Cooper, and Schrieffer, fully expected that he would be the one to crack the problem. It did not work out that way.

  17. [Iron ore, economic geology and networks of experts between Wisconsin and the state of Minas Gerais, 1881-1914].

    PubMed

    Fischer, Georg

    2014-01-01

    This article deals with the "discovery" of Brazilian iron ore from two perspectives. The first examines the increasing emphasis of the geosciences and their practical application and global reach since the second half of the nineteenth century. While in Brazil economic geology was integrated step by step into state institutions, at the global level it experienced its moment of triumph with the 11th International Geological Congress in 1910. The second deals with a specific social network with a decisive role in the race for Brazilian iron ore: with transnational experts juggling between the logic of the market and that of the academy. The article reveals the importance of local negotiations in the incorporation of the subsoil of Minas Gerais into the global space of mining.

  18. Estimation of the true ileal digestible lysine and sulfur amino acid requirement and comparison of the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine in eleven- to twenty-six-kilogram nursery pigs.

    PubMed

    Yi, G F; Gaines, A M; Ratliff, B W; Srichana, P; Allee, G L; Perryman, K R; Knight, C D

    2006-07-01

    Three experiments were conducted to determine the true ileal digestible (TID) Lys and sulfur AA (SAA) requirement and to compare the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid (HMTBA) and dl-MET as Met sources in nursery pigs. Experiment 1 included 2 studies: 1 was 662 nursery pigs (Triumph 4 x PIC C22; initial BW 12.2 +/- 0.18 kg) allotted to 1 of 5 dietary treatments with TID Lys concentrations ranging from 1.10 to 1.50%; and the second study was 665 nursery pigs (Triumph 4 x PIC C22; initial BW 12.3 +/- 0.18 kg) allotted to 1 of 5 dietary treatments with TID SAA concentration ranging from 0.63 to 0.90%. In Exp. 2, 638 nursery pigs (Triumph 4 x PIC C22; initial BW 13.0 +/- 0.16 kg) were allotted to the same 5 SAA dietary treatments as in Exp. 1. In Exp. 3, 1,232 pigs (Triumph 4 x PIC C22; initial BW 11.0 +/- 0.30 kg) were allotted to 1 of 7 dietary treatments. The basal diet (diet 1) was supplemented with high concentrations of synthetic AA but no Met; this resulted in a dietary concentration of TID Lys of 1.30% and TID SAA of 0.50%. Diets 2 to 7 were the basal diet supplemented with 3 equimolar levels of HMTBA or dl-MET to provide TID SAA concentrations of 0.56, 0.62, and 0.68%, respectively. In Exp. 1, increasing TID Lys from 1.10 to 1.50% increased ADG (quadratic; P < 0.05) and improved G:F (linear; P < 0.002). The pooled data of Exp. 1 (SAA study) and Exp. 2 indicated that increasing TID SAA from 0.63 to 0.90% increased ADG (quadratic; P < 0.01) and improved G:F (quadratic; P < 0.01). Various methods of analyzing the growth response surface indicated that the optimal TID Lys concentration ranged from 1.28 to 1.32% for ADG (Exp. 1), and the optimal TID SAA concentration ranged from 0.73 to 0.77% for ADG and 0.80 to 0.83% for G:F (pooled Exp. 1 and 2), respectively. In Exp. 3, increasing TID SAA concentrations from 0.50 to 0.68% resulted in a linear improvement of ADG (P < 0.001), ADFI (P < 0.05), and G:F (P < 0.001). The best fit comparison of HMTBA

  19. Targeting CD8+ T-cell tolerance for cancer immunotherapy.

    PubMed

    Jackson, Stephanie R; Yuan, Jinyun; Teague, Ryan M

    2014-01-01

    In the final issue of Science in 2013, the American Association of Science recognized progress in the field of cancer immunotherapy as the 'Breakthrough of the Year.' The achievements were actually twofold, owing to the early success of genetically engineered chimeric antigen receptors (CAR) and to the mounting clinical triumphs achieved with checkpoint blockade antibodies. While fundamentally very different, the common thread of these independent strategies is the ability to prevent or overcome mechanisms of CD8(+) T-cell tolerance for improved tumor immunity. Here we discuss how circumventing T-cell tolerance has provided experimental insights that have guided the field of clinical cancer immunotherapy to a place where real breakthroughs can finally be claimed.

  20. Ross E. Baker, DC: A Canadian chiropractic survivor

    PubMed Central

    Brown, Douglas M.

    2014-01-01

    This paper is an historical biography of a fortunate man. It begins with a glimpse of Ross E. Baker’s origins in south-western Ontario, watches him going to school and working in Hamilton before joining the Canadian Army and shipping off to Europe to fight in the Second World War. At War’s end, the article picks up Dr. Baker as he comes home, starts a family, becomes a chiropractor and sustains a viable practice. Now in the twilight of life, the good doctor is last seen content with his retirement, spending days at his cottage property, reviewing his memoirs and reflecting on the tumult, terror and eventual triumph of the D-Day landing at Normandy. PMID:24587499

  1. The Teaching of Physics in Cuba from Colonial Times to 1959

    NASA Astrophysics Data System (ADS)

    Altshuler, José; Baracca, Angelo

    The present paper will concentrate on the study of the first one and a half centuries of the teaching of physics in Cuba, starting from the early interest or activities in this. To provide the appropriate context, we will begin by going back in time to the early local signs of a modern scientific sensitivity, scornful of scholastic teaching and fond of experimental approaches, under the belated but stimulating influence of the European Enlightenment. We will go over individual cases during the initial phase of the country's academic physics in some detail, firstly during the initial period of colonial rule, and then from the beginning of the twentieth century to the triumph of the 1959 Revolution earlier that year. We thus hope to make the fundamental aspects of our subject reasonably consistent and abiding, even though further historical research may eventually throw new light on relevant details, personalities and events.

  2. Small(pox) success?

    PubMed

    Birn, Anne-Emanuelle

    2011-02-01

    The 30th anniversary of the World Health Organization's (WHO) official certification of smallpox eradication was marked by a slew of events hailing the campaign's dramatic tale of technological and organizational triumph against an ancient scourge. Yet commemorations also serve as moments of critical reflection. This article questions the acclaim showered upon smallpox eradication as the single greatest public health success in history. It examines how and why smallpox eradication and WHO's concurrent social justice-oriented primary health care approach (following from the Declaration of Alma-Ata) became competing paradigms. It synthesizes critiques of eradication's shortcomings and debunks some of the myths surrounding the global eradication campaign as a public health priority and necessity, and as a Cold War victory of cooperation. The article concludes with thoughts on integrating technical and social-political aspects of health within the context of welfare states as the means to achieving widespread and enduring global public health success. PMID:21340334

  3. Seeing Jay-Z in Taipei.

    PubMed

    Hsu, Hua

    2011-01-01

    How does the newly arrived immigrant respond to the news that an identity already awaits him? How does an African American hip-hop artist translate his struggles and triumphs across oceanic divides? What significance do American demographic shifts have in a global context? Hsu's essay examines what happens once individuals or identities migrate beyond the contexts that first produced them. He explores a variety of circuits: the satellite communities of Asian immigrant students who arrived on American university campuses in the late 1960s; enduring debates about a "post-city" identity, spurred by advances in cheap, efficient, world-shrinking communication technologies; and the new affinities and categories of self-identification made possible by a present-day culture that prizes interactivity and participation. PMID:21473166

  4. Filling-enforced quantum band insulators in spin-orbit coupled crystals.

    PubMed

    Po, Hoi Chun; Watanabe, Haruki; Zaletel, Michael P; Vishwanath, Ashvin

    2016-04-01

    An early triumph of quantum mechanics was the explanation of metallic and insulating behavior based on the filling of electronic bands. A complementary, classical picture of insulators depicts electrons as occupying localized and symmetric Wannier orbitals that resemble atomic orbitals. We report the theoretical discovery of band insulators for which electron filling forbids such an atomic description. We refer to them as filling-enforced quantum band insulators (feQBIs) because their wave functions are associated with an essential degree of quantum entanglement. Like topological insulators, which also do not admit an atomic description, feQBIs need spin-orbit coupling for their realization. However, they do not necessarily support gapless surface states. Instead, the band topology is reflected in the insulating behavior at an unconventional filling. We present tight binding models of feQBIs and show that they only occur in certain nonsymmorphic, body-centered cubic crystals.

  5. The DSM and learning difficulties: formulating a genealogy of the learning-disabled subject.

    PubMed

    Katchergin, Ofer

    2016-06-01

    The article examines the manner in which the learning-disabled subject is created as an object within contemporary psychiatric discourse by means of a genealogical analysis of the learning-disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM). It investigates how this pathology was formed historically in the text, what metamorphoses it underwent, and their epistemic significance. First, the theoretical underpinnings of the sociological discourse on DSM are presented, giving a brief background of the DSM status in the Israeli context. Many problematic characteristics in the text are unveiled, by means of critiques from sociology, anthropology and discourse studies. Second, the changing definitions and conceptualizations of learning-disorders in the seven editions of the Manual and the accompanying case studies (1952-2013) are examined. It becomes apparent that the disorders have undergone changes that have enabled the biomedical paradigm to triumph. The implications of these transformations are addressed. PMID:26956872

  6. There is grandeur in this view of Newton: Charles Darwin, Isaac Newton and Victorian conceptions of scientific virtue.

    PubMed

    Bellon, Richard

    2014-01-01

    For Victorian men of science, the scientific revolution of the seventeenth century represented a moral awakening. Great theoretical triumphs of inductive science flowed directly from a philosophical spirit that embraced the virtues of self-discipline, courage, patience and humility. Isaac Newton exemplified this union of moral and intellectual excellence. This, at least, was the story crafted by scientific leaders like David Brewster, Thomas Chalmers, John Herschel, Adam Sedgwick and William Whewell. Not everyone accepted this reading of history. Evangelicals who decried the 'materialism' of mainstream science assigned a different meaning to Newton's legacy on behalf of their 'scriptural' alternative. High-church critics of science like John Henry Newman, on the other hand, denied that Newton's secular achievements carried any moral significance at all. These debates over Newtonian standards of philosophical behavior had a decisive influence on Charles Darwin as he developed his theory of evolution by natural selection.

  7. An historical, biographical, literary, and clinical consideration of Freud's 'Analysis Terminable and Interminable' on its fiftieth birthday.

    PubMed

    Loewenberg, P

    1988-01-01

    Freud's paper is re-examined and placed in biographical and historical context, Moses and monotheism (1934-1938) is treated as a parallel text. Freud's ironic scepticism is viewed against the background of Thomas Mann's 1936 idealization of psychoanalysis. Freud was a sick and dying man in 1937 with every reason for personal pessimism. The political setting was the triumph of fascism in Austria and the impending seizure of Austria by Hitler. Freud fantasized the protection of psychoanalysis by the Roman Catholic Church. The paper is a polemic against the theories of Ferenczi, Adler, and Rank. Contemporaneous defence of prophylactic analysis by Fenichel is reviewed. Freud's political judgement of the moral equivalence of Social Democracy and fascism is critiqued. Freud's injunction to periodic re-analysis and his vision of analysis as 'unending' is supported. The possibility of intergenerational prophylaxis is presented. PMID:3042656

  8. AIDS and transfer factor: myths, certainties and realities.

    PubMed

    Viza, D

    1996-01-01

    At the end of the 20th century, the triumph of biology is as indisputable as that of physics was at the end of the 19th century, and so is the might of the inductive thought. Virtually all diseases have been seemingly conquered and HIV, the cause of AIDS, has been fully described ten years after the onset of the epidemic. However, the triumph of biological science is far from being complete. The toll of several diseases, such as cancer, continues to rise and the pathogenesis of AIDS remains elusive. In the realm of inductive science, the dominant paradigm can seldom be challenged in a frontal attack, especially when it is apparently successful, and only what Kuhn calls "scientific revolutions" can overthrow it. Thus, it is hardly surprising that the concept of transfer factor is considered with contempt, and the existence of the moiety improbable: over forty years after the introduction of the concept, not only its molecular structure remains unknown, but also its putative mode of action contravenes dogmas of both immunology and molecular biology. And when facts challenge established dogmas, be in religion, philosophy or science, they must be suppressed. Thus, results of heterodox research become henceforth nisi-i.e., valid unless cause is shown for rescinding them, because they challenge the prevalent paradigm. However, when observations pertain to lethal disorders, their suppression in the name of dogmas may become criminal. Because of the failure of medical science to manage the AIDS pandemic, transfer factor, which has been successfully used for treating or preventing viral infections, may today overcome a priori prejudice and rejection more swiftly. In science, as in life, certainties always end up by dying, and Copernicus' vision by replacing that of Ptolemy.

  9. AIDS and transfer factor: myths, certainties and realities.

    PubMed

    Viza, D

    1996-01-01

    At the end of the 20th century, the triumph of biology is as indisputable as that of physics was at the end of the 19th century, and so is the might of the inductive thought. Virtually all diseases have been seemingly conquered and HIV, the cause of AIDS, has been fully described ten years after the onset of the epidemic. However, the triumph of biological science is far from being complete. The toll of several diseases, such as cancer, continues to rise and the pathogenesis of AIDS remains elusive. In the realm of inductive science, the dominant paradigm can seldom be challenged in a frontal attack, especially when it is apparently successful, and only what Kuhn calls "scientific revolutions" can overthrow it. Thus, it is hardly surprising that the concept of transfer factor is considered with contempt, and the existence of the moiety improbable: over forty years after the introduction of the concept, not only its molecular structure remains unknown, but also its putative mode of action contravenes dogmas of both immunology and molecular biology. And when facts challenge established dogmas, be in religion, philosophy or science, they must be suppressed. Thus, results of heterodox research become henceforth nisi-i.e., valid unless cause is shown for rescinding them, because they challenge the prevalent paradigm. However, when observations pertain to lethal disorders, their suppression in the name of dogmas may become criminal. Because of the failure of medical science to manage the AIDS pandemic, transfer factor, which has been successfully used for treating or preventing viral infections, may today overcome a priori prejudice and rejection more swiftly. In science, as in life, certainties always end up by dying, and Copernicus' vision by replacing that of Ptolemy. PMID:8993753

  10. Geology and mineral deposits of the Minnie Moore and Bullion mineralized areas, Blaine County, Idaho

    USGS Publications Warehouse

    Link, Paul Karl; Worl, Ronald G.

    2001-01-01

    In the early 1880?s the discovery of rich ores in the Minnie Moore and Bullion mineralized areas sparked a rush to settle and develop the Wood River valley. Silver and lead discoveries in these areas spurred the boom in mining after completion of the Oregon Short Line Railroad to Hailey in 1883. In both areas the ore comprises galena, sphalerite, and tetrahedrite in a gangue of siderite, calcite, or quartz. Minor goldbearing quartz veins are also present. The ore is in fissure and replacement veins along fracture systems that formed in Late Cretaceous time, after intrusion of nearby granodiorite or quartz diorite stocks. The ore formed under mesothermal conditions and heat was supplied by the nearby plutons. In the Minnie Moore area, the mineralized veins are cut by low-angle normal faults that are of probable Eocene age. In the Minnie Moore mineralized area, the host rock is the middle part of the Devonian Milligen Formation, (the informal Lucky Coin limestone and Triumph argillite), which is the same stratigraphic level as the host ore in the rich Triumph mine northeast of Hailey. In the Bullion mineralized area, the ore is hosted by the lower member of the Middle Pennsylvanian to Lower Permian Dollarhide Formation. Rich ore was mined in several tunnels that reached the Mayflower vein, a northwest-striking mineralized shear zone. The deposits are thought to be mainly mesothermal veins that formed in association with Cretaceous magmatism. The syngenetic stratiform model of ore formation has often been applied to these deposits, however, no evidence of syngenetic mineralization was found in this study. Faulting has displaced most of the major orebodies and thus has made mining these deposits a challenge.

  11. The New York Stem Cell Foundation. Interview with Susan Solomon.

    PubMed

    Solomon, Susan

    2012-11-01

    We caught up with Susan Solomon, Co-Founder of The New York Stem Cell Foundation, to discuss the role of the Foundation in facilitating some of the top advances in stem cell science in recent years. Susan L Solomon is Chief Executive Officer and Co-Founder of The New York Stem Cell Foundation (NYSCF), a nonprofit organization established in 2005 to accelerate cures through stem cell research. A longtime healthcare advocate, Susan is a founding member and current President of New Yorkers for the Advancement of Medical Research, is on the Executive Committee for the Alliance for Regenerative Medicine, and she has been a member of the Board of Directors of the Juvenile Diabetes Research Foundation, New York Chapter. Susan was also a member of the Strategic Planning Committee of the Empire State Stem Cell Board. In March 2008, Susan received a New York State Women of Excellence Award from the Governor of New York. In September 2008, she received the Triumph Award from the Brooke Ellison Foundation for her work in establishing NYSCF. Prior to founding NYSCF, Susan, an attorney, spent much of her career building businesses. She established and ran Solomon Partners LLC to provide strategic management consulting to corporations, cultural institutions, foundations and nonprofit organizations. She has also held executive positions at MacAndrews and Forbes Holdings and MMG Patricof and Co. She was the founding Chief Executive Officer of Sothebys.com and was President of Sony Worldwide Networks. PMID:23210823

  12. DR and CR: Recent advances in technology.

    PubMed

    Schaefer-Prokop, C M; De Boo, D W; Uffmann, M; Prokop, M

    2009-11-01

    After some initial reluctance, nowadays transition from conventional analogue-to-digital radiographic technique is realized in the vast majority of institutions. The eventual triumph of digital over conventional technique is related to its undoubted advantages with respect to image quality and improved image handling in the context of a picture archiving and communication system. CR represents the older system, which matured over decades and experienced some important recent improvements with respect to dose efficiency and work-flow efficiency that strengthened its position. It represents a very versatile, economically attractive system that is equally suited for integrated systems as well as for cassette-based imaging at the bedside. DR systems offer superb image quality and realistic options for dose reduction based on their high dose efficiency. While for a long time only integrated systems were on the market suited for a large patient throughput, also mobile DR systems became recently available. While for the next years, it is likely that DR and CR systems will coexist, the long term perspective of CR will depend on further innovations with respect to dose efficiency and signal-to-noise characteristics while for DR economical aspects and broader availability of mobile systems will play a role. PMID:19695809

  13. Lewis Wolpert discusses development and depression. Interview by Joanne Clough.

    PubMed

    Wolpert, Lewis

    2004-06-01

    Lewis Wolpert is Professor of Biology as Applied to Medicine in the Department of Anatomy and Developmental Biology at University College, London, UK. His research interests focus on the mechanisms that are involved in embryonic development. Lewis originally trained as a civil engineer in South Africa but in 1955 made the move to research in cellular biology at King's College, London. He was made a Fellow of the Royal Society in 1980 and awarded the CBE in 1990. Lewis was also made a Fellow of the Royal Society of Literature in 1999 and has presented science on both radio and TV for several years. He was awarded The Royal Society Michael Faraday Prize in 2000 for his contribution to the public understanding of science, most notably through his Chairmanship of the Committee for the Public Understanding of Science (COPUS; 1993-1998). He is the author of numerous books, including Malignant Sadness: The Anatomy of Depression, Principles of Development, The Unnatural Nature of Science and The Triumph of the Embryo. He also writes a regular column for The Independent. PMID:15149619

  14. Improved Regression Analysis of Temperature-Dependent Strain-Gage Balance Calibration Data

    NASA Technical Reports Server (NTRS)

    Ulbrich, N.

    2015-01-01

    An improved approach is discussed that may be used to directly include first and second order temperature effects in the load prediction algorithm of a wind tunnel strain-gage balance. The improved approach was designed for the Iterative Method that fits strain-gage outputs as a function of calibration loads and uses a load iteration scheme during the wind tunnel test to predict loads from measured gage outputs. The improved approach assumes that the strain-gage balance is at a constant uniform temperature when it is calibrated and used. First, the method introduces a new independent variable for the regression analysis of the balance calibration data. The new variable is designed as the difference between the uniform temperature of the balance and a global reference temperature. This reference temperature should be the primary calibration temperature of the balance so that, if needed, a tare load iteration can be performed. Then, two temperature{dependent terms are included in the regression models of the gage outputs. They are the temperature difference itself and the square of the temperature difference. Simulated temperature{dependent data obtained from Triumph Aerospace's 2013 calibration of NASA's ARC-30K five component semi{span balance is used to illustrate the application of the improved approach.

  15. For the love of love: neoliberal governmentality, neoliberal melancholy, critical intersectionality, and the advent of solidarity with the other Mormons.

    PubMed

    Lee, Wenshu

    2012-01-01

    This article performs critical intellectual labor for social and political change against neoliberalism in three ways. First, it explores and connects neoliberal governmentality and neoliberal melancholy, two anchor experiences in our twenty-first century political quotidian. Second, it engages in the sense making of Proposition 8 (a California voter initiative to ban same-sex marriage, which was narrowly passed in 2008) as a case study of religious organizations (the Mormon Church and their religious allies) and their complicity with neoliberal states to foster subjection and subjectivation through critical intersectionality that goes beyond the identity trinity of race, class, and gender. Finally, the article suggests two technologies as a new hand to outplay the excess of neoliberalism for the triumph of our common humanity: 1) mourning over the devastation brought about by neoliberalism and 2) loving our love for those with whom we usually do not form affinity connections, such as the other Mormons, those who are othered because of their departure from church orthodoxy.

  16. Chronic myeloid leukemia: reminiscences and dreams

    PubMed Central

    Mughal, Tariq I.; Radich, Jerald P.; Deininger, Michael W.; Apperley, Jane F.; Hughes, Timothy P.; Harrison, Christine J.; Gambacorti-Passerini, Carlo; Saglio, Giuseppe; Cortes, Jorge; Daley, George Q.

    2016-01-01

    With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people’s lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman. PMID:27132280

  17. Stapp`s quantum dualism: The James/Heisenberg model of consciousness

    SciTech Connect

    Noyes, H.P.

    1994-02-18

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James` description of conscious events and for matter from Werner Heisenberg`s ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author`s opinion fails to establish a monistic, scientific theory. The author traces Stapp`s failure to his adamant rejection of arbitrariness, or `randomness`. This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin`s explanation of biology, let along the triumphs of modern `neo-Darwinism`. The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp`s views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy.

  18. Unanswered Questions in the Electroweak Theory

    SciTech Connect

    Quigg, Chris

    2009-11-01

    This article is devoted to the status of the electroweak theory on the eve of experimentation at CERN's Large Hadron Collider. A compact summary of the logic and structure of the electroweak theory precedes an examination of what experimental tests have established so far. The outstanding unconfirmed prediction of the electroweak theory is the existence of the Higgs boson, a weakly interacting spin-zero particle that is the agent of electroweak symmetry breaking, the giver of mass to the weak gauge bosons, the quarks, and the leptons. General arguments imply that the Higgs boson or other new physics is required on the TeV energy scale. Indirect constraints from global analyses of electroweak measurements suggest that the mass of the standard-model Higgs boson is less than 200 GeV. Once its mass is assumed, the properties of the Higgs boson follow from the electroweak theory, and these inform the search for the Higgs boson. Alternative mechanisms for electroweak symmetry breaking are reviewed, and the importance of electroweak symmetry breaking is illuminated by considering a world without a specific mechanism to hide the electroweak symmetry. For all its triumphs, the electroweak theory has many shortcomings.

  19. ‘Don't play the butter notes’: jazz in medical education

    PubMed Central

    Bradner, Melissa; Harper, Darryl V.; Ryan, Mark H.; Vanderbilt, Allison A.

    2016-01-01

    Jazz has influenced world music and culture globally – attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing – his sound was routine. Miles Davis told him in a low husky murmur, ‘Don't play the butter notes’. In medical education, ‘don't play the butter notes’ suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years. PMID:27095009

  20. Resilience to Leaking — Dynamic Systems Modeling of Information Security

    PubMed Central

    Hamacher, Kay

    2012-01-01

    Leaking of confidential material is a major threat to information security within organizations and to society as a whole. This insight has gained traction in the political realm since the activities of Wikileaks, which hopes to attack ‘unjust’ systems or ‘conspiracies’. Eventually, such threats to information security rely on a biologistic argument on the benefits and drawbacks that uncontrolled leaking might pose for ‘just’ and ‘unjust’ entities. Such biological metaphors are almost exclusively based on the economic advantage of participants. Here, I introduce a mathematical model of the complex dynamics implied by leaking. The complex interactions of adversaries are modeled by coupled logistic equations including network effects of econo-communication networks. The modeling shows, that there might arise situations where the leaking envisioned and encouraged by Wikileaks and the like can strengthen the defending entity (the ‘conspiracy’). In particular, the only severe impact leaking can have on an organization seems to originate in the exploitation of leaks by another entity the organization competes with. Therefore, the model suggests that leaks can be used as a `tactical mean’ in direct adversary relations, but do not necessarily increase public benefit and societal immunization to ‘conspiracies’. Furthermore, within the model the exploitation of the (open) competition between entities seems to be a more promising approach to control malicious organizations : divide-et-impera policies triumph here. PMID:23227151

  1. Resilience to leaking--dynamic systems modeling of information security.

    PubMed

    Hamacher, Kay

    2012-01-01

    Leaking of confidential material is a major threat to information security within organizations and to society as a whole. This insight has gained traction in the political realm since the activities of Wikileaks, which hopes to attack 'unjust' systems or 'conspiracies'. Eventually, such threats to information security rely on a biologistic argument on the benefits and drawbacks that uncontrolled leaking might pose for 'just' and 'unjust' entities. Such biological metaphors are almost exclusively based on the economic advantage of participants. Here, I introduce a mathematical model of the complex dynamics implied by leaking. The complex interactions of adversaries are modeled by coupled logistic equations including network effects of econo-communication networks. The modeling shows, that there might arise situations where the leaking envisioned and encouraged by Wikileaks and the like can strengthen the defending entity (the 'conspiracy'). In particular, the only severe impact leaking can have on an organization seems to originate in the exploitation of leaks by another entity the organization competes with. Therefore, the model suggests that leaks can be used as a `tactical mean' in direct adversary relations, but do not necessarily increase public benefit and societal immunization to 'conspiracies'. Furthermore, within the model the exploitation of the (open) competition between entities seems to be a more promising approach to control malicious organizations : divide-et-impera policies triumph here. PMID:23227151

  2. Mate choice and sexual selection: what have we learned since Darwin?

    PubMed

    Jones, Adam G; Ratterman, Nicholas L

    2009-06-16

    Charles Darwin laid the foundation for all modern work on sexual selection in his seminal book The Descent of Man, and Selection in Relation to Sex. In this work, Darwin fleshed out the mechanism of sexual selection, a hypothesis that he had proposed in The Origin of Species. He went well beyond a simple description of the phenomenon by providing extensive evidence and considering the far-reaching implications of the idea. Here we consider the contributions of Darwin to sexual selection with a particular eye on how far we have progressed in the last 150 years. We focus on 2 key questions in sexual selection. First, why does mate choice evolve at all? And second, what factors determine the strength of mate choice (or intensity of sexual selection) in each sex? Darwin provided partial answers to these questions, and the progress that has been made on both of these topics since his time should be seen as one of the great triumphs of modern evolutionary biology. However, a review of the literature shows that key aspects of sexual selection are still plagued by confusion and disagreement. Many of these areas are complex and will require new theory and empirical data for complete resolution. Overall, Darwin's contributions are still surprisingly relevant to the modern study of sexual selection, so students of evolutionary biology would be well advised to revisit his works. Although we have made significant progress in some areas of sexual selection research, we still have much to accomplish. PMID:19528643

  3. Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants.

    PubMed

    Gagliano, Sarah A; Ravji, Reena; Barnes, Michael R; Weale, Michael E; Knight, Jo

    2015-08-24

    Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, statistical learning has been widely investigated for prioritizing genetic variants likely to be associated with complex disease. We compared three published prioritization procedures, which use different statistical learning algorithms and different predictors with regard to the quantity, type and coding. We also explored different combinations of algorithm and annotation set. As an application, we tested which methodology performed best for prioritizing variants using data from a large schizophrenia meta-analysis by the Psychiatric Genomics Consortium. Results suggest that all methods have considerable (and similar) predictive accuracies (AUCs 0.64-0.71) in test set data, but there is more variability in the application to the schizophrenia GWAS. In conclusion, a variety of algorithms and annotations seem to have a similar potential to effectively enrich true risk variants in genome-scale datasets, however none offer more than incremental improvement in prediction. We discuss how methods might be evolved for risk variant prediction to address the impending bottleneck of the new generation of genome re-sequencing studies.

  4. Biofuels 2020: Biorefineries based on lignocellulosic materials.

    PubMed

    Valdivia, Miguel; Galan, Jose Luis; Laffarga, Joaquina; Ramos, Juan-Luis

    2016-09-01

    The production of liquid biofuels to blend with gasoline is of worldwide importance to secure the energy supply while reducing the use of fossil fuels, supporting the development of rural technology with knowledge-based jobs and mitigating greenhouse gas emissions. Today, engineering for plant construction is accessible and new processes using agricultural residues and municipal solid wastes have reached a good degree of maturity and high conversion yields (almost 90% of polysaccharides are converted into monosaccharides ready for fermentation). For the complete success of the 2G technology, it is still necessary to overcome a number of limitations that prevent a first-of-a-kind plant from operating at nominal capacity. We also claim that the triumph of 2G technology requires the development of favourable logistics to guarantee biomass supply and make all actors (farmers, investors, industrial entrepreneurs, government, others) aware that success relies on agreement advances. The growth of ethanol production for 2020 seems to be secured with a number of 2G plants, but public/private investments are still necessary to enable 2G technology to move on ahead from its very early stages to a more mature consolidated technology. PMID:27470921

  5. Ignaz Philipp Semmelweis, the prophet of bacteriology.

    PubMed

    Wyklicky, H; Skopec, M

    1983-01-01

    Although by 1931 I. Ph. Semmelweis' achievements and the tragedy of his life had been given their due place in the history of mankind, Alexander Fränkel, formerly Theodor Billroth's assistant and later his biographer, critically stated that the discoverer of the causes of puerperal fever should have defended his discovery with facts rather than with fanaticism. It was only a few years after Semmelweis' death, for instance, that Billroth made laborious experiments. Billroth's work on Coccobacteria had important implications and even influenced Robert Koch, although his hypotheses did not really predict the pathogenic and specific nature of microbes. In 1847 Semmelweis postulated his theory; ie, that the pathological-anatomical changes which he observed in the bodies of the women who died in childbed, in their newborn infants, and in the autopsy findings on his friend Jakob Kolletschka were an entity, morphologically and clinically. He summed them up under the concept of pyemia. Even though Semmelweis was continually abhorred by the evident statistics and would have been able to prove his discovery through animal experiments, he primarily took to the pen to defend his opinion vehemently. Only the clinical facts proved him right during his lifetime; the triumph of bacteriology which began after his death made him not only the "savior of mothers" but also a genial ancestor of bacteriology. PMID:6354955

  6. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    DOE PAGES

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-05-12

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate ofmore » the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. We find our results point at a large Fermi surface consistent with Luttinger's theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition.« less

  7. Large-Eddy Simulations of Magnetohydrodynamic Turbulence in Heliophysics and Astrophysics

    NASA Astrophysics Data System (ADS)

    Miesch, Mark; Matthaeus, William; Brandenburg, Axel; Petrosyan, Arakel; Pouquet, Annick; Cambon, Claude; Jenko, Frank; Uzdensky, Dmitri; Stone, James; Tobias, Steve; Toomre, Juri; Velli, Marco

    2015-11-01

    We live in an age in which high-performance computing is transforming the way we do science. Previously intractable problems are now becoming accessible by means of increasingly realistic numerical simulations. One of the most enduring and most challenging of these problems is turbulence. Yet, despite these advances, the extreme parameter regimes encountered in space physics and astrophysics (as in atmospheric and oceanic physics) still preclude direct numerical simulation. Numerical models must take a Large Eddy Simulation (LES) approach, explicitly computing only a fraction of the active dynamical scales. The success of such an approach hinges on how well the model can represent the subgrid-scales (SGS) that are not explicitly resolved. In addition to the parameter regime, heliophysical and astrophysical applications must also face an equally daunting challenge: magnetism. The presence of magnetic fields in a turbulent, electrically conducting fluid flow can dramatically alter the coupling between large and small scales, with potentially profound implications for LES/SGS modeling. In this review article, we summarize the state of the art in LES modeling of turbulent magnetohydrodynamic (MHD) flows. After discussing the nature of MHD turbulence and the small-scale processes that give rise to energy dissipation, plasma heating, and magnetic reconnection, we consider how these processes may best be captured within an LES/SGS framework. We then consider several specific applications in heliophysics and astrophysics, assessing triumphs, challenges, and future directions.

  8. The discovery of the microphthalmia locus and its gene, Mitf

    PubMed Central

    Arnheiter, Heinz

    2010-01-01

    Summary The history of the discovery of the microphthalmia locus and its gene, now called Mitf, is a testament to the triumph of serendipity. Although the first microphthalmia mutation was discovered among the descendants of a mouse that was irradiated for the purpose of mutagenesis, the mutation most likely was not radiation-induced but occurred spontaneously in one of the parents of a later breeding. Although Mitf might eventually have been identified by other molecular genetic techniques, it was first cloned from a chance transgene insertion at the microphthalmia locus. And although Mitf was found to encode a member of a well-known transcription factor family, its analysis might still be in its infancy had Mitf not turned out to be of crucial importance for the physiology and pathology of many distinct organs, including eye, ear, immune system, bone, and skin, and in particular for melanoma. In fact, near seven decades of Mitf research have led to many insights about development, function, degeneration, and malignancies of a number of specific cell types, and it is hoped that these insights will one day lead to therapies benefitting those afflicted with diseases originating in these cell types. PMID:20807369

  9. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

    PubMed Central

    Cantas, L.; Shah, Syed Q. A.; Cavaco, L. M.; Manaia, C. M.; Walsh, F.; Popowska, M.; Garelick, H.; Bürgmann, H.; Sørum, H.

    2013-01-01

    The discovery and introduction of antimicrobial agents to clinical medicine was one of the greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial infections. However, the gradual emergence of populations of antimicrobial-resistant pathogenic bacteria resulting from use, misuse, and abuse of antimicrobials has today become a major global health concern. Antimicrobial resistance (AMR) genes have been suggested to originate from environmental bacteria, as clinically relevant resistance genes have been detected on the chromosome of environmental bacteria. As only a few new antimicrobials have been developed in the last decade, the further evolution of resistance poses a serious threat to public health. Urgent measures are required not only to minimize the use of antimicrobials for prophylactic and therapeutic purposes but also to look for alternative strategies for the control of bacterial infections. This review examines the global picture of antimicrobial resistance, factors that favor its spread, strategies, and limitations for its control and the need for continuous training of all stake-holders i.e., medical, veterinary, public health, and other relevant professionals as well as human consumers, in the appropriate use of antimicrobial drugs. PMID:23675371

  10. The Prime Minister and the platypus: A paradox goes to war.

    PubMed

    Lawrence, Natalie

    2012-03-01

    In February 1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain. This request can only be understood if placed in the context of Churchill's passion for exotic pets as well as the rich history of aristocratic menageries and live diplomatic gifts. Obtaining an animal hitherto unseen alive in Europe would have been a great zoological achievement for London Zoo and secured British authority in heated historical taxonomical debates. This zoological triumph, coupled with accomplishing an extravagant enterprise in the middle of war-time austerity would have boosted public morale. Most importantly, despite its death, the platypus, served as a token for mediating the soured relations between Australia and Britain. Churchill's platypus provides a unique case of animal collecting that incorporates effects on international diplomacy and public relations along with a great private eccentricity and passion. PMID:22326098

  11. [On the psychoanalytic view of Harry Potter].

    PubMed

    Subkowski, Peter

    2008-01-01

    This paper analyzes the exemplary mental development that Harry Potter undertakes after the massive traumatic loss of his parents at the early age of 15 months and the following neglect by his relatives until he becomes a mature adult. On the basis of his internalized mothers love and by identification with his father and his paternally friend Dumbledore Harry gains increasing self-confidence and new friends in his peer group in the course of time. After passing numerous conflicts and experiencing friendship Harry reaches the stage of initiation into the world of the adults. On the oedipal level he finally is able to deidealize his father and Dumbledore. And at the end Harry is not seduced by absolute power and the triumph over death itself. On the contrary he is ready to sacrifice himself for his friends and thus can overcome the fragmented Voldemort. Readers can identify with Harry, can recognize their own experiences and conflicts and can deal with the proposed conflict resolution patterns on different levels. This contemporary "Bildungsroman" deals with important typical interpersonal and cultural issues for young people. This is what leads young readers to strong resonance and identification processes and explains the great success of the Harry Potter story.

  12. There ain't nothing like a Dame: a commentary on Lonsdale (1947) ‘Divergent beam X-ray photography of crystals’

    PubMed Central

    Glazer, A. M.

    2015-01-01

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon–carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750139

  13. The Evolution of Autonomy.

    PubMed

    Stammers, Trevor

    2015-01-01

    There can be little doubt, at least in the Western world, that autonomy is theruling principle in contemporary bioethics. In spite of its 'triumph' however,the dominance of the utilitarian concept of autonomy is being increasinglyquestioned. In this paper, I explore the nature of autonomy, how it came todisplace the Hippocratic tradition in medicine and how different conceptsof autonomy have evolved. I argue that the reduction of autonomy to'the exercise of personal choice' in medicine has led to a 'tyranny of autonomy' which can be inimical to ethical medical practice rather than conducive to it.I take the case of Kerrie Wooltorton as an illustration of how misplacedadherence to respect for patient autonomy can lead to tragic consequences.An analysis of autonomy based on the work of Rachel Haliburton isdescribed and applied to the role of autonomy in a recent bioethicaldebate--that arising from Savulescu's proposal that conscientious objection by health-care professionals should not be permitted in the NHS. Inconclusion, I suggest Kukla's concept of conscientious autonomy as onepromising pathway to circumvent both the limitations and adverse effectsof the dominance of current (mis)understandings of autonomy in biomedical ethics.

  14. Roe v. Wade. Catholic wisdom.

    PubMed

    Maguire, D

    1998-01-01

    In this commentary, a Roman Catholic professor of moral theory recounts how, during his doctoral work in Rome, he was taught that abortion was intrinsically evil and could never be justified. He was also taught, however, about Probabilism, a Roman Catholic teaching that held that "where there is doubt, there is freedom." In other words, serious doubts based on a person's own insights allow a person moral freedom to choose a course of action in cases of debated moral issues. This moral teaching, a triumph for the rights of personal conscience, which was formulated in the 16th and 17th centuries, has been well-hidden from the laity and neglected by the clergy during the past 100 years. He also learned about Thomas Aquinas who taught that practical moral principals are valid most of the time but can have exceptions depending on circumstances. In addition, early 17th-century church leaders justified abortions performed to save the life of the women. Thus, the Supreme Court's decision in Roe seems to reflect Catholic thinking more accurately than the Vatican's new-found absolutism against abortion.

  15. A Limited Positioning System for Memory

    PubMed Central

    Shapiro, Matthew

    2015-01-01

    The 2014 Nobel Prize for Physiology or Medicine is an enormous triumph for John O’Keefe and May-Britt and Edvard Moser and an historic event for cognitive and behavioral neuroscience. Neuronal representations decoded from action potentials form a mechanistic bridge between brain and mind and demonstrate the continuity of psychology with biology and physical science. The cognitive map theory powered an ongoing, international research program inspired by Hebb (1949 The Organization of Behavior. New York, NY: Wiley) that showed the way toward linking specific patterns of neuronal activity to high level representation and processing. The prize celebrates a path that led from fundamental, philosophical questions about psychological space to enduring, scientific facts: place, head direction, grid, and boundary fields in the hippocampus, presubiculum, entorhinal cortex, and other brain circuits provide a cellular basis for spatial behavior, learning, and memory. By awarding this prize, the Nobel committee affirmed neuroethology and comparative psychology, marked the end of a chapter in one debate about the existence of animal cognition, and recognized cognitive neurophysiology. The “inner GPS” in the brain” demonstrates “a cellular basis for higher cognitive function.” Animals represent, process, and use information defined by abstract relationships among items (O’Keefe and Conway, 1978) to guide flexible, goal-directed actions. Beyond raising the ontological status of “animal mind,” the committee agreed that abstract mental representations can be investigated rigorously by recording single unit activity in the brain of behaving animals. PMID:25800503

  16. Antibodies: an alternative for antibiotics?

    PubMed

    Berghman, L R; Abi-Ghanem, D; Waghela, S D; Ricke, S C

    2005-04-01

    In 1967, the success of vaccination programs, combined with the seemingly unstoppable triumph of antibiotics, prompted the US Surgeon General to declare that "it was time to close the books on infectious diseases." We now know that the prediction was overly optimistic and that the fight against infectious diseases is here to stay. During the last 20 yr, infectious diseases have indeed made a staggering comeback for a variety of reasons, including resistance against existing antibiotics. As a consequence, several alternatives to antibiotics are currently being considered or reconsidered. Passive immunization (i.e., the administration of more or less pathogen-specific antibodies to the patient) prior to or after exposure to the disease-causing agent is one of those alternative strategies that was almost entirely abandoned with the introduction of chemical antibiotics but that is now gaining interest again. This review will discuss the early successes and limitations of passive immunization, formerly referred to as "serum therapy," the current use of antibody administration for prophylaxis or treatment of infectious diseases in agriculture, and, finally, recent developments in the field of antibody engineering and "molecular farming" of antibodies in various expression systems. Especially the potential of producing therapeutic antibodies in crops that are routine dietary components of farm animals, such as corn and soy beans, seems to hold promise for future application in the fight against infectious diseases. PMID:15844826

  17. Mate choice and sexual selection: what have we learned since Darwin?

    PubMed

    Jones, Adam G; Ratterman, Nicholas L

    2009-06-16

    Charles Darwin laid the foundation for all modern work on sexual selection in his seminal book The Descent of Man, and Selection in Relation to Sex. In this work, Darwin fleshed out the mechanism of sexual selection, a hypothesis that he had proposed in The Origin of Species. He went well beyond a simple description of the phenomenon by providing extensive evidence and considering the far-reaching implications of the idea. Here we consider the contributions of Darwin to sexual selection with a particular eye on how far we have progressed in the last 150 years. We focus on 2 key questions in sexual selection. First, why does mate choice evolve at all? And second, what factors determine the strength of mate choice (or intensity of sexual selection) in each sex? Darwin provided partial answers to these questions, and the progress that has been made on both of these topics since his time should be seen as one of the great triumphs of modern evolutionary biology. However, a review of the literature shows that key aspects of sexual selection are still plagued by confusion and disagreement. Many of these areas are complex and will require new theory and empirical data for complete resolution. Overall, Darwin's contributions are still surprisingly relevant to the modern study of sexual selection, so students of evolutionary biology would be well advised to revisit his works. Although we have made significant progress in some areas of sexual selection research, we still have much to accomplish.

  18. German suffering in the Franco–German War, 1870/71.

    PubMed

    Krüger, Christine G

    2011-01-01

    Suffering during the Franco–Prussian War of 1870/71 has to be interpreted in the context of three developments: the willingness to alleviate wartime suffering, which had led to the foundation of the International Red Cross and the Geneva Convention a few years earlier, the industrialization of war, which had enormously increased the efficiency of the weaponry, and the nationalization of war. For many Germans, the outcome of the war justified the wartime suffering, which was often trivialized in the media. The small number of authors who saw the high casualty numbers and the pain of the victims as a warning about the consequences of modern warfare usually belonged to the anti-Prussian opposition. Nationalist euphoria in the face of victory and German unification drowned out such critics, whose patriotism was in doubt. Finally, the remembrance of the war during the Kaiserreich aimed largely at celebrating the triumph of the German army and the foundation of the national state. The glorification of the military was hardly compatible with a detailed description of the misery of the battlefield and the pain of war victims. In 1870/71 and in the subsequent decades, nationalism overwhelmed and eventually excluded a humanitarian narrative. PMID:22141174

  19. The polio narratives: dialogues with FDR.

    PubMed

    Fairchild, A L

    2001-01-01

    As a group of accounts that span the decades from the mid-1940s to the present, the published polio narratives enable us to align their shifting perceptions of disability with social, cultural, and technological change. This paper identifies two distinct groups of narratives. Authors of the first group, writing between the mid-1930s and mid-1950s--a period of relative prosperity, conformity, and homogeneity--were uncomfortable with radical movements, diversity, and conflict; their narratives typically told of either full or substantial recovery. Beginning in the mid-1950s--the period of both McCarthy and the Civil Rights movement--a second wave of narratives begins to tell stories of partial to serious disability; typically, they reflect on a lifetime of coping with chronic disability. Both sets of narratives, however, represent a dialogue with Franklin Delano Roosevelt. Roosevelt himself, journalists, and the National Foundation for Infantile Paralysis all helped to create and promote a core polio narrative featuring FDR's triumph over disease and disability that would become a national myth. Yet while the early narratives reinforced the core elements of the Roosevelt myth, the later ones began to challenge them.

  20. Disability and narrative: new directions for medicine and the medical humanities.

    PubMed

    Garden, Rebecca

    2010-12-01

    People with disabilities are a large minority that disproportionately seeks medical care. However, disability is relatively neglected in medical education and practice, and disabled people experience troubling differences and even disparities in healthcare. Practitioners can help improve healthcare for disabled people through disability studies, a multi-disciplinary field of enquiry that draws on the experiences and perspectives of people with disabilities to address discrimination. This article outlines a disability studies perspective on healthcare, specifically the rejection of the medicalisation of disability and difference in favour of an understanding of disability that focuses on social factors that disable, such as stigmatisation and a lack of accommodation. The 'social model' of disability can be expanded to chronic illness and to the broader work of the medial humanities. The author argues that narrative, particularly first-person accounts, provide a critical resource by representing the point of view of people with disabilities and by offering a means of examining the social context and social determinants of disability. The author examines specific conventions of narrative, the dominant plotlines such as the triumph over adversity, that predetermine experiences of disability and illness. Through disability studies and critical examinations of narrative informed by disability studies, practitioners can provide better care for patients with disabilities and work as allies towards more equitable relations in the clinic.

  1. The bioethical principles and Confucius' moral philosophy.

    PubMed

    Tsai, D F-C

    2005-03-01

    This paper examines whether the modern bioethical principles of respect for autonomy, beneficence, non-maleficence, and justice proposed by Beauchamp and Childress are existent in, compatible with, or acceptable to the leading Chinese moral philosophy-the ethics of Confucius. The author concludes that the moral values which the four prima facie principles uphold are expressly identifiable in Confucius' teachings. However, Confucius' emphasis on the filial piety, family values, the "love of gradation", altruism of people, and the "role specified relation oriented ethics" will inevitably influence the "specification" and application of these bioethical principles and hence tend to grant "beneficence" a favourable position that diminishes the respect for individual rights and autonomy. In contrast, the centrality of respect for autonomy and its stance of "first among equals" are more and more stressed in Western liberal viewpoints. Nevertheless, if the Confucian "doctrine of Mean" (chung-yung) and a balanced "two dimensional personhood" approach are properly employed, this will require both theorists and clinicians, who are facing medical ethical dilemmas, of searching to attain due mean out of competing moral principles thus preventing "giving beneficence a priority" or "asserting autonomy must triumph".

  2. Scipione Riva-Rocci and the men behind the mercury sphygmomanometer.

    PubMed

    Roguin, A

    2006-01-01

    The history of the blood pressure (BP) concept and measurements is described. Many scientists were involved. Among them, major triumphs were achieved by William Harvey during the early 1600s who announced that there is a finite amount of blood that circulated the body in one direction only. In the mid-1700s, Reverend Stephen Hales reported the first invasive measurement in horses and smaller animals. Poiseuille introduced in the early 1800s the mercury hydrodynometer and the mmHg units. Karl von-Vierordt described in 1855 that with enough pressure, the arterial pulse could be obliterated. He also created the sphygmograph, a pulse recorder usable for routine non-invasive monitoring on humans. In 1881, von Basch created the sphygmomanometer and the first non-invasive BP measurements. However, in 1896, Scipione Riva-Rocci developed further the mercury sphygmomanometer, almost as we know it today. The sphygmomanometer could only be used to determine the systolic BP. Observing the pulse disappearance via palpitation would only allow the measuring physician to observe the point when the artery was fully constricted. Nikolai Korotkoff was the first to observe the sounds made by the constriction of the artery in 1905. PMID:16409431

  3. RADWASTE SOLUTIONS MISSION ACCOMPLISHED AT HANFORD SPENT NUCLEAR FUEL (SNF) REMOVAL CONCLUDES IN HUGE VICTORY

    SciTech Connect

    GERBER, M.S.

    2004-10-06

    Removing the largest collection of radioactive materials bordering the Columbia River at the Department of Energy's (DOE's) Hanford Site in southeast Washington state was successfully completed on a glorious autumn morning in 2004. The Spent Nuclear Fuel (SNF) Project, managed for DOE by prime contractor Fluor Hanford, removed more than 2,300 tons (2,100 metric tons [MT]) of irradiated uranium fuel--just over 4.65-million pounds--from a historic reactor area along the river's shore, called the ''Hanford Reach.'' The Project also dried the fuel and placed all of it in safe, dry, interim storage in central Hanford, nine miles from the Columbia and hundreds of feet above the groundwater table, effectively neutralizing the risks formerly posed by the decaying fuel. Removing the nearly 105,000 irradiated, solid metal uranium fuel assemblies--stored for decades underwater in the aging K Basins--marked a cornerstone event in Hanford's long farewell to arms. It was the third major triumph in a ''trifecta'' year at the old site, during which a Fluor Hanford-managed project completed stabilizing and safely packaging nearly 20 tons of plutonium-bearing materials, and another project finished pumping all liquids out of degrading, underground waste tanks. All three successful projects give traction to the vision and promise of DOE's Richland Operations Office (RL), to move wastes and special nuclear material away from the river and into Hanford's Central plateau.

  4. Passion and profession, doctors in skirts: the letters of doctors Frieda Fraser and Edith Bickerton Williams.

    PubMed

    Perdue, Katherine

    2005-01-01

    "Passion and Profession; Doctors in Skirts," is based on the extensive correspondence between Dr. Frieda Fraser and Dr. Edith Bickerton Williams, two Canadian women who were lovers from 1924 and life partners from 1937, until the death of Dr. Williams in 1979. Dr. Fraser became a prominent researcher and lecturer of Microbiology at the University of Toronto. Dr. Williams was one of the first women in North America to graduate as a Veterinarian. Dr. Frieda Fraser's medical training afforded her the freedom to foster a same-sex relationship with her partner Edith. Her freedom was constrained however, as women interns were placed in institutions thought appropriate for their sex, and prospects of private practice for a woman doctor were bleak. The letters' candid accounts of conflicts with male authority, challenges to ideas about sexuality, and the pervasiveness of prejudice, often reinforced by the scientific community, are important to the History of Medicine. The paper demonstrated that the same-sex relationship and identity, developed in the course of the Fraser/Williams correspondence, proved a primary source of strength in the face of the doctors' tribulations and triumphs as professionals in the medical field.

  5. The discovery of the microphthalmia locus and its gene, Mitf.

    PubMed

    Arnheiter, Heinz

    2010-12-01

    The history of the discovery of the microphthalmia locus and its gene, now called Mitf, is a testament to the triumph of serendipity. Although the first microphthalmia mutation was discovered among the descendants of a mouse that was irradiated for the purpose of mutagenesis, the mutation most likely was not radiation induced but occurred spontaneously in one of the parents of a later breeding. Although Mitf might eventually have been identified by other molecular genetic techniques, it was first cloned from a chance transgene insertion at the microphthalmia locus. And although Mitf was found to encode a member of a well-known transcription factor family, its analysis might still be in its infancy had Mitf not turned out to be of crucial importance for the physiology and pathology of many distinct organs, including eye, ear, immune system, bone, and skin, and in particular for melanoma. In fact, near seven decades of Mitf research have led to many insights about development, function, degeneration, and malignancies of a number of specific cell types, and it is hoped that these insights will one day lead to therapies benefitting those afflicted with diseases originating in these cell types.

  6. Signaling in T cells – is anything the m(a)TOR with the picture(s)?

    PubMed Central

    Boothby, Mark

    2016-01-01

    The excitement surrounding checkpoint inhibitors in the treatment of patients with cancer exemplifies a triumph of the long-term value of investing in basic science and fundamental questions of T-cell signaling. The pharmaceutical future actively embraces ways of making more patients’ cancers responsive to these inhibitors. Such a process will be aided by elucidation of signaling and regulation. With thousands of articles spread across almost 30 years, this commentary can touch only on portions of the canonical picture of T-cell signaling and provide a few parables from work on mammalian (or mechanistic) target of rapamycin (mTOR) pathways as they link to early and later phases of lymphocyte activation. The piece will turn a critical eye to some issues with models about these pathways in T cells. Many of the best insights lie in the future despite all that is uncovered already, but a contention is that further therapeutic successes will be fostered by dealing with disparities among findings and attention to the temporal, spatial, and stochastic aspects of T-cell responses. Finally, thoughts on some (though not all) items urgently needed for future progress will be mooted. PMID:26949528

  7. Global environmental politics: Lessons from Montreal

    SciTech Connect

    Kauffman, J. )

    1994-01-01

    When 24 nations and the European Community signed the Montreal Protocol in September, 1987, it was widely praised for its reflection of unprecedented foresight in mandating preventive action on a global scale. Such praise may have been premature in light of more recent revelations that: (1) the rates of ozone depletion appear to be accelerating; and (2) the depletion seems to be spreading into the summer months over the north temperate zone of latitudes. Although there is still controversy over what the effects of such depletion ultimately will be, most nations of the world, including all of the advanced industrialized countries, agree that chlorofluorocarbons (CFCs) must be phased out of all production and use, and they are taking steps to do that before the turn of the century. Two distinctly different conclusions are thus possible regarding the outcome of the negotiations. As the first successfully negotiated multilateral agreement to address a global environmental problem, the Protocol is seen by many to be a triumph of environmental awareness and international cooperation. To other observers, however, the struggle for domestic commercial interests and national political debates that led to delays in action may already be causing serious and irreversible damage that could have been avoided. In short, the negotiation process worked, but it took to long for nations to agree that it was necessary and to begin the process.

  8. The sun and exoplanets: The solitude of man

    NASA Astrophysics Data System (ADS)

    Kotov, V. A.

    2012-06-01

    Solar pulsations with a period of P 0 = 9600.606(12) were discovered in 1974. A more recent discovery is that planetary distances in the solar system are subject to spatial resonance with the parameter L 0 ≡ cP 0 ≈ 9600 ls and that the P 0 pulsation itself has cosmological significance (coherent cosmic oscillation, or the pace of absolute time of the universe; c is the speed of light). As of June 2011, 552 extrasolar planets have been discovered. Statistical analysis shows that the distribution of the semimajor axes of alien planets does not have L 0 resonance. Moreover, it appears to have no resonance at all. This frustrates the 20th-century hopes for the existence of extraterrestrial civilizations and possible contact with them. They are simply not there. This explanation of the Fermi paradox, or the Great Silence, appears to rest on the triumph of the anthropic principle, which has been successfully implemented by nature within our planetary system. This leads to a vision whereby the cosmos seems to be created specially for us. The scale L 0 indicates that the sun is a special quantum object, where L 0 is a wave function parameter that is not subject to the rational principles of the classical world, but rather follows a peculiar, quantum logic.

  9. And the next 50 years? The future of recombinant DNA technology in oral medicine.

    PubMed

    Slavkin, H C

    1996-01-01

    As we celebrate this spectacular 50th anniversary, fluoridation continues to be the most effective public health strategy to reduce the disease burden of dental caries. Curiously, while H. Trendley Dean and his colleagues at the National Institutes of Health were investigating the effects of fluoride on tooth enamel in the mid-1930s, two young boys, one in London and the other in Chicago, were growing up to become the catalysts for another "biological revolution." These two very talented individuals, James Watson and Francis Crick, would later meet by accident at Cambridge and produce their seminal discovery published in April 1953 as a letter in Nature, a one-page article provoking an international scientific adventure to understand living organisms in terms of the structure and function of deoxyribonucleic acid (DNA), a universal genetic code and a rationale for the applications of recombinant DNA technology (rDNA) in fields as diverse as agriculture, energy, industry, and health. As we now reflect upon the triumphs from fluoridation and ponder the next 50 years and the complexities of craniofacial, oral, and dental diseases, it becomes increasingly evident that recombinant DNA technology coupled with health promotion, disease prevention, and public education offers the promise for remarkable advances in prevention, diagnosis, and therapeutics in oral medicine.

  10. Exergy and productivity

    SciTech Connect

    Soma, J.

    1983-02-01

    With the fates of entire industries in the balance in the world's competitive economic battlegrounds, the leading competitor will be the one that is most productive in its sphere of competition. Conservation and competition are unnatural bedfellows. The most adept competitors will use the best principles of productive scientific management to seek the path of least action (Hamilton's principle) and least time (Fermat's principle) to triumph over their competitors' incomplete and insufficient conceptions of management. Exergy management can work in productive synergy with sound economic principles and other valid productivity principles to define and decide on optimal paths for a corporation to follow within existing degrees of freedom. It has identified its AEU and found its proper economics--exergioeconomics. It will encourage other managements to identify, say, their APUs (American Productivity Units) and their proper economics. When other managements follow suit, the revivified corporate entity will be admirably qualified to compete in the marketplace and reap the rewards that production economics offers through optimum allocation and utilization of energy, labor, capital and materials.

  11. I. Juvara (1913-1996), a surgeon for all seasons.

    PubMed

    Tarcoveanu, E; Dorobat, D; Vasilescu, A; Van Hee, R

    2015-01-01

    Ion Juvara is a creator of a genuine Romanian school of surgery. If I. Juvara had lived and worked in a country that had been the proud owner of a Pantheon, undoubtedly he would have rested there to the end of time, among the eternal ones i.e. those who triumphed against time and who had never been defeated. If the first generation of Romanian surgeons represented mainly by Thoma Ionesco (1860-1926) was educated mainly abroad, the next generation was trained professionally at the Romanian school of surgery. Despite of the hostile period he lived in, I. Juvara kept intact his freedom of thinking and opposed with all his powers abuses of any kind, always preserving his integrity, avoiding with elegance the traps of the totalitarian regime. But even so nobody can state that the professor, who came from -Moldavia, as his master, N. Hortolomei, could not say at the end of his life that he hadn't had a fulfilled professional life, as he is considered even today the greatest surgeon of Romania in the latter half of the 20th century. He was, after all, a surgeon for all seasons.

  12. Weddell Sea exploration from ice station

    NASA Astrophysics Data System (ADS)

    Ice Station Weddell Group of Principal Investigators; Chief Scientists; Gordon, Arnold L.

    On January 18, 1915, the Endurance and Sir Ernest Shackleton and his crew were stranded in the ice of the Weddell Sea and began one of the most famous drifts in polar exploration. Shackleton turned a failure into a triumph by leading all of his team to safety [Shackleton, 1919]. The drift track of the Endurance and the ice floe occupied by her stranded crew after the ship was lost on November 21, 1915, at 68°38.5‧S and 52°26.5‧W, carried the group along the western rim of the Weddell Gyre, representing a rare human presence in this region of perennial sea-ice cover.Seventy-seven years later, in 1992, the first intentional scientific Southern Ocean ice drift station, Ice Station Weddell-1 (ISW-1), was established in the western Weddell Sea by a joint effort of the United States and Russia. ISW-1 followed the track of the Endurance closely (Figure 1) and gathered an impressive array of data in this largely unexplored corner of the Southern Ocean, the western edge of the Weddell Gyre.

  13. Skin lighteners, Black consumers and Jewish entrepreneurs in South Africa.

    PubMed

    Thomas, Lynn M

    2012-01-01

    This article considers the rise and decline of South Africa's lucrative and controversial skin-lighteners market through examination of the business history of the largest manufacturers, Abraham and Solomon Krok, and their evolving personas as millionaires and philanthropists. Such examination reveals how the country's skin-lighteners trade emerged as part of the broader growth of a black consumer market after the Second World War and how elements of that market became the target of anti-apartheid protests in subsequent decades. It also demonstrates how the Kroks' experiences as second-generation Jewish immigrants shaped their involvement in the trade and how, later, their self-identification as Jewish philanthropists informed their efforts to rehabilitate their reputations following South Africa's 1990 ban on all skin lighteners. Such efforts include the building of Johannesburg's highly acclaimed Apartheid Museum, modelled after the United States Holocaust Memorial Museum. This article explores the profound ironies that some South Africans see in the fact that a museum dedicated to commemorating those who suffered under and, ultimately, triumphed against state racism was financed by a family fortune generated through the sale of skin lighteners to black consumers.

  14. Donor wave functions in Si gauged by STM images

    NASA Astrophysics Data System (ADS)

    Saraiva, A. L.; Salfi, J.; Bocquel, J.; Voisin, B.; Rogge, S.; Capaz, Rodrigo B.; Calderón, M. J.; Koiller, Belita

    2016-01-01

    The triumph of effective mass theory in describing the energy spectrum of dopants does not guarantee that the model wave functions will withstand an experimental test. Such wave functions have recently been probed by scanning tunneling spectroscopy, revealing localized patterns of resonantly enhanced tunneling currents. We show that the shape of the conducting splotches resembles a cut through Kohn-Luttinger (KL) hydrogenic envelopes, which modulate the interfering Bloch states of conduction electrons. All the nonmonotonic features of the current profile are consistent with the charge density fluctuations observed between successive {001 } atomic planes, including a counterintuitive reduction of the symmetry—a heritage of the lowered point group symmetry at these planes. A model-independent analysis of the diffraction figure constrains the value of the electron wave vector to k0=(0.82 ±0.03 ) (2 π /aSi) . Unlike prior measurements, averaged over a sizable density of electrons, this estimate is obtained directly from isolated electrons. We further investigate the model-specific anisotropy of the wave function envelope, related to the effective mass anisotropy. This anisotropy appears in the KL variational wave function envelope as the ratio between Bohr radii b /a . We demonstrate that the central-cell-corrected estimates for this ratio are encouragingly accurate, leading to the conclusion that the KL theory is a valid model not only for energies but for wave functions as well.

  15. The Chemical Synthesis of Discodermolide

    NASA Astrophysics Data System (ADS)

    Paterson, I.; Florence, G. J.

    The marine sponge-derived polyketide discodermolide is a potent antimitotic agent that represents a promising natural product lead structure in the treatment of cancer. Discodermolide shares the same microtubule-stabilising mechanism of action as Taxol®, inhibits the growth of solid tumours in animal models and shows synergy with Taxol. The pronounced cytotoxicity of discodermolide, which is maintained against cancer cell lines that display resistance to Taxol and other drugs, combined with its scarce availability from its natural source, has fuelled significant academic and industrial interest in devising a practical total synthesis as a means of ensuring a sustainable supply for drug development. This chapter surveys the various total syntheses of discodermolide that have been completed over the period 1993-2007, focusing on the strategies employed for introduction of the multiple stereocentres and achieving control over the alkene geometry, along with the various methods used for realising the pivotal fragment couplings to assemble progressively the full carbon skeleton. This dedicated synthetic effort has triumphed in removing the supply problem for discodermolide, providing sufficient material for extensive biological studies and enabling its early stage clinical development, as well as facilitating SAR studies for lead optimisation.

  16. Sexual excitement.

    PubMed

    Stoller, R J

    1976-08-01

    Sexual excitement depends on a scenario the person to be aroused has been writing since childhood. The story is an adventure, an autobiography disguised as fiction, in which the hero/heroine hides crucial intrapsychic conflicts, mysteries, screen memories of actual traumatic events and the resolution of these elements into a happy ending, best celebrated by orgasm. The function of the fantasy is to take these painful experiences and convert them to pleasure-triumph. In order to sharpen excitement-the vibration between the fear of original traumas repeating and the hope of a pleasurable conclusion this time-one introduces into the story elements of risk (approximations of the trauma) meant to prevent boredom and safety factors (sub-limnal signals to the storyteller that the risk are not truly dangerous). Sexual fantasy can be studied by means of a person's daydreams (including those chosen in magazines, books, plays, television, movies, and outright pornography), masturbatory behavior, object choice, foreplay, techniques of intercourse, or postcoital behavior. PMID:949223

  17. General Relativity and Gravitation

    NASA Astrophysics Data System (ADS)

    Ashtekar, Abhay; Berger, Beverly; Isenberg, James; MacCallum, Malcolm

    2015-07-01

    Part I. Einstein's Triumph: 1. 100 years of general relativity George F. R. Ellis; 2. Was Einstein right? Clifford M. Will; 3. Cosmology David Wands, Misao Sasaki, Eiichiro Komatsu, Roy Maartens and Malcolm A. H. MacCallum; 4. Relativistic astrophysics Peter Schneider, Ramesh Narayan, Jeffrey E. McClintock, Peter Mészáros and Martin J. Rees; Part II. New Window on the Universe: 5. Receiving gravitational waves Beverly K. Berger, Karsten Danzmann, Gabriela Gonzalez, Andrea Lommen, Guido Mueller, Albrecht Rüdiger and William Joseph Weber; 6. Sources of gravitational waves. Theory and observations Alessandra Buonanno and B. S. Sathyaprakash; Part III. Gravity is Geometry, After All: 7. Probing strong field gravity through numerical simulations Frans Pretorius, Matthew W. Choptuik and Luis Lehner; 8. The initial value problem of general relativity and its implications Gregory J. Galloway, Pengzi Miao and Richard Schoen; 9. Global behavior of solutions to Einstein's equations Stefanos Aretakis, James Isenberg, Vincent Moncrief and Igor Rodnianski; Part IV. Beyond Einstein: 10. Quantum fields in curved space-times Stefan Hollands and Robert M. Wald; 11. From general relativity to quantum gravity Abhay Ashtekar, Martin Reuter and Carlo Rovelli; 12. Quantum gravity via unification Henriette Elvang and Gary T. Horowitz.

  18. Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial.

    PubMed

    2013-06-01

    The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study. PMID:23608306

  19. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed Central

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-01-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment. PMID:12634133

  20. There ain't nothing like a Dame: a commentary on Lonsdale (1947) 'Divergent beam X-ray photography of crystals'.

    PubMed

    Glazer, A M

    2015-04-13

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon-carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

  1. Exploding cities: housing the masses in Paris, Chicago, and Mexico City, 1850-2000.

    PubMed

    Platt, Harold L

    2010-01-01

    In The Mystery of Capitalism , the darling of neoliberalism, Hernando de Soto posits that secure property titles explain “why capitalism triumphs in the West and fails everywhere else.” While social scientists have taken him to task for an oversimplification of the causes and remedies of poverty, historians have contributed little to this important policy debate. Applying comparative methods across time and space, such a retrospective analysis exposes serious flaws in de Soto’s thesis. Case studies of Paris, Chicago, and Mexico City covering successive, fifty-year periods support his contention that property law was the single most important factor in determining the fate of rural migrants trying to find a place to live in these exploding cities. But in each case, residential property played a far more complex role in creating the social and physical geography of the city than its simple exchange value. This article illuminates some of these alternative economic uses and embedded cultural meanings of identities of place. It also shows how urban growth machines create capital value in property for some by creating environmental injustice of substandard conditions of everyday life for others. PMID:20827834

  2. (Mis)understanding Science: The Problem with Scientific Breakthroughs.

    PubMed

    Evans, James P

    2016-09-01

    On Saturday morning, February 28, 1953, the mystery of heredity appeared secure. Humans hadn't the faintest idea of how genetic information was transmitted-how the uncanny resemblance between mother and daughter, grandfather and grandson was conveyed across generations. Yet, by that Saturday afternoon, two individuals, James Watson and Francis Crick, had glimpsed the solution to these mysteries. The story of Watson and Crick's great triumph has been told and retold and has rightly entered the pantheon of scientific legend. But Watson and Crick's breakthrough was just that: a rupture and dramatic discontinuity in human knowledge that solved a deep mystery, the likes of which occurs, perhaps, a couple of times each century. And that's the problem. The story is just so good and so irresistible that it has misled generations of scientists about what to expect regarding a life in science. And more damaging, the resulting breakthrough mentality misleads the public, the media, and society's decision-makers about how science really works, all to the detriment of scientific progress and our society's well-being. PMID:27649823

  3. German suffering in the Franco–German War, 1870/71.

    PubMed

    Krüger, Christine G

    2011-01-01

    Suffering during the Franco–Prussian War of 1870/71 has to be interpreted in the context of three developments: the willingness to alleviate wartime suffering, which had led to the foundation of the International Red Cross and the Geneva Convention a few years earlier, the industrialization of war, which had enormously increased the efficiency of the weaponry, and the nationalization of war. For many Germans, the outcome of the war justified the wartime suffering, which was often trivialized in the media. The small number of authors who saw the high casualty numbers and the pain of the victims as a warning about the consequences of modern warfare usually belonged to the anti-Prussian opposition. Nationalist euphoria in the face of victory and German unification drowned out such critics, whose patriotism was in doubt. Finally, the remembrance of the war during the Kaiserreich aimed largely at celebrating the triumph of the German army and the foundation of the national state. The glorification of the military was hardly compatible with a detailed description of the misery of the battlefield and the pain of war victims. In 1870/71 and in the subsequent decades, nationalism overwhelmed and eventually excluded a humanitarian narrative.

  4. Space Geodesy Monitoring Mass Transport in Global Geophysical Fluids

    NASA Technical Reports Server (NTRS)

    Chao, Benjamin F.

    2004-01-01

    Mass transports occurring in the atmosphere-hydrosphere-cryosphere-solid Earth-core system (the 'global geophysical fluids') are important geophysical phenomena. They occur on all temporal and spatial scales. Examples include air mass and ocean circulations, oceanic and solid tides, hydrological water and idsnow redistribution, mantle processes such as post-glacial rebound, earthquakes and tectonic motions, and core geodynamo activities. The temporal history and spatial pattern of such mass transport are often not amenable to direct observations. Space geodesy techniques, however, have proven to be an effective tool in monitorihg certain direct consequences of the mass transport, including Earth's rotation variations, gravitational field variations, and the geocenter motion. Considerable advances have been made in recent years in observing and understanding of these geodynamic effects. This paper will use several prominent examples to illustrate the triumphs in research over the past years under a 'Moore's law' in space geodesy. New space missions and projects promise to further advance our knowledge about the global mass transports. The latter contributes to our understanding of the geophysical processes that produce and regulate the mass transports, as well as of the solid Earth's response to such changes in terms of Earth's mechanical properties.

  5. How are they doing? Listening as fathers of children with autism spectrum disorder compare themselves to fathers of children who are typically developing.

    PubMed

    Cheuk, Samantha; Lashewicz, Bonnie

    2016-04-01

    The growing prevalence of autism spectrum disorder is accompanied by ongoing efforts to understand and support parents in the face of challenges related to their child's autism spectrum disorder. Although fathers are increasingly hands-on in raising children, research focus on parenting children with autism spectrum disorder continues to be skewed toward experiences of mothers. Our purpose in this article is to contribute understandings of how fathers of children with autism spectrum disorder perceive themselves to be managing, and we undertake this by examining comparisons fathers of children with autism spectrum disorder make between their parenting experiences and experiences of fathers of typically developing children. A purposive sample of 28 fathers of children (aged 2-13 years) with autism spectrum disorder living in an urban center in Western Canada participated in in-depth interviews about their parenting successes and challenges. We found fathers speak of universal fathering experiences yet articulate their own sense of loss and efforts to come to terms with unanticipated demands associated with autism spectrum disorder. Fathers of children with autism spectrum disorder feel "pangs of jealousy" toward fathers of typically developing children, yet they are keenly attentive to their own child's development and convey a sense of gratitude for their child's capabilities and personality amidst an appreciation for trials and triumphs of fathering in general and fathering a child with autism spectrum disorder in particular.

  6. The chemical synthesis of discodermolide.

    PubMed

    Paterson, I; Florence, G J

    2009-01-01

    The marine sponge-derived polyketide discodermolide is a potent antimitotic agent that represents a promising natural product lead structure in the treatment of cancer. Discodermolide shares the same microtubule-stabilising mechanism of action as Taxol(®), inhibits the growth of solid tumours in animal models and shows synergy with Taxol. The pronounced cytotoxicity of discodermolide, which is maintained against cancer cell lines that display resistance to Taxol and other drugs, combined with its scarce availability from its natural source, has fuelled significant academic and industrial interest in devising a practical total synthesis as a means of ensuring a sustainable supply for drug development. This chapter surveys the various total syntheses of discodermolide that have been completed over the period 1993-2007, focusing on the strategies employed for introduction of the multiple stereocentres and achieving control over the alkene geometry, along with the various methods used for realising the pivotal fragment couplings to assemble progressively the full carbon skeleton. This dedicated synthetic effort has triumphed in removing the supply problem for discodermolide, providing sufficient material for extensive biological studies and enabling its early stage clinical development, as well as facilitating SAR studies for lead optimisation.

  7. Alexander A Friedmann

    NASA Astrophysics Data System (ADS)

    Tropp, Eduard A.; Frenkel, Viktor Ya.; Chernin, Artur D.

    1993-06-01

    Our universe can be described mathematically by a simple model developed in 1922 at Petrograd (St. Petersburg) by Alexander Friedmann (1888-1925). Without the benefit of observational evidence, Friedmann predicted that the whole universe would expand and evolve with time. This astonishing prediction was confirmed seven years later by Edwin Hubble. Its originator, unfortunately didn't live to savor this triumph. This vivid biography of an outstanding scientist sets his life and work against a wide backdrop of the history of cosmological studies and its major players, such as Einstein and others. The book is a window on Friedmann's school and university years, military service, and teaching and research during a seminal period of Soviet history. The authors include unique archival material, such as Friedmann's letters from the Russian Front, as well as contemporary records and reminiscences of colleagues. There is a detailed treatment of his work in theoretical cosmology (1922-1924), set in the context of the organization of Soviet science at the time.

  8. I. Juvara (1913-1996), a surgeon for all seasons.

    PubMed

    Tarcoveanu, E; Dorobat, D; Vasilescu, A; Van Hee, R

    2015-01-01

    Ion Juvara is a creator of a genuine Romanian school of surgery. If I. Juvara had lived and worked in a country that had been the proud owner of a Pantheon, undoubtedly he would have rested there to the end of time, among the eternal ones i.e. those who triumphed against time and who had never been defeated. If the first generation of Romanian surgeons represented mainly by Thoma Ionesco (1860-1926) was educated mainly abroad, the next generation was trained professionally at the Romanian school of surgery. Despite of the hostile period he lived in, I. Juvara kept intact his freedom of thinking and opposed with all his powers abuses of any kind, always preserving his integrity, avoiding with elegance the traps of the totalitarian regime. But even so nobody can state that the professor, who came from -Moldavia, as his master, N. Hortolomei, could not say at the end of his life that he hadn't had a fulfilled professional life, as he is considered even today the greatest surgeon of Romania in the latter half of the 20th century. He was, after all, a surgeon for all seasons. PMID:26021954

  9. There ain't nothing like a Dame: a commentary on Lonsdale (1947) 'Divergent beam X-ray photography of crystals'.

    PubMed

    Glazer, A M

    2015-04-13

    Prof. Dame Kathleen Lonsdale was one of the two first female Fellows of the Royal Society, having originally been a student of that great British scientist and Nobel Laureate William Henry Bragg. She came to fame initially for her solution of the crystal structure of hexamethyl benzene, thus demonstrating that the benzene ring was flat, of considerable importance to organic chemistry, where it had been proposed before but without proof. This was at a time when the solution of crystal structures was in its infancy, and in its day this work was considered a triumph. As a rare example then of a female physicist, Lonsdale became interested in various aspects of the diffraction of X-rays, and in particular published an important paper on a form of diffraction in which a strongly divergent source was used rather than the usual highly collimated beam. The photographs thus obtained showed a series of arcs and circles, whose positions were so sensitive that they could be used to determine the quality of crystals such as diamond, and even to calculate their lattice dimensions, and hence carbon-carbon bond lengths, to hitherto extraordinary precision. Lonsdale also became known not just as a scientist but as a peace activist and an active member of the Society of Friends. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750139

  10. Roe v. Wade. Catholic wisdom.

    PubMed

    Maguire, D

    1998-01-01

    In this commentary, a Roman Catholic professor of moral theory recounts how, during his doctoral work in Rome, he was taught that abortion was intrinsically evil and could never be justified. He was also taught, however, about Probabilism, a Roman Catholic teaching that held that "where there is doubt, there is freedom." In other words, serious doubts based on a person's own insights allow a person moral freedom to choose a course of action in cases of debated moral issues. This moral teaching, a triumph for the rights of personal conscience, which was formulated in the 16th and 17th centuries, has been well-hidden from the laity and neglected by the clergy during the past 100 years. He also learned about Thomas Aquinas who taught that practical moral principals are valid most of the time but can have exceptions depending on circumstances. In addition, early 17th-century church leaders justified abortions performed to save the life of the women. Thus, the Supreme Court's decision in Roe seems to reflect Catholic thinking more accurately than the Vatican's new-found absolutism against abortion. PMID:12178884

  11. Think globally, act locally: the role of local demographics and vaccination coverage in the dynamic response of measles infection to control.

    PubMed

    Ferrari, M J; Grenfell, B T; Strebel, P M

    2013-08-01

    The global reduction of the burden of morbidity and mortality owing to measles has been a major triumph of public health. However, the continued persistence of measles infection probably not only reflects local variation in progress towards vaccination target goals, but may also reflect local variation in dynamic processes of transmission, susceptible replenishment through births and stochastic local extinction. Dynamic models predict that vaccination should increase the mean age of infection and increase inter-annual variability in incidence. Through a comparative approach, we assess national-level patterns in the mean age of infection and measles persistence. We find that while the classic predictions do hold in general, the impact of vaccination on the age distribution of cases and stochastic fadeout are mediated by local birth rate. Thus, broad-scale vaccine coverage goals are unlikely to have the same impact on the interruption of measles transmission in all demographic settings. Indeed, these results suggest that the achievement of further measles reduction or elimination goals is likely to require programmatic and vaccine coverage goals that are tailored to local demographic conditions.

  12. The Evolution of Autonomy.

    PubMed

    Stammers, Trevor

    2015-01-01

    There can be little doubt, at least in the Western world, that autonomy is theruling principle in contemporary bioethics. In spite of its 'triumph' however,the dominance of the utilitarian concept of autonomy is being increasinglyquestioned. In this paper, I explore the nature of autonomy, how it came todisplace the Hippocratic tradition in medicine and how different conceptsof autonomy have evolved. I argue that the reduction of autonomy to'the exercise of personal choice' in medicine has led to a 'tyranny of autonomy' which can be inimical to ethical medical practice rather than conducive to it.I take the case of Kerrie Wooltorton as an illustration of how misplacedadherence to respect for patient autonomy can lead to tragic consequences.An analysis of autonomy based on the work of Rachel Haliburton isdescribed and applied to the role of autonomy in a recent bioethicaldebate--that arising from Savulescu's proposal that conscientious objection by health-care professionals should not be permitted in the NHS. Inconclusion, I suggest Kukla's concept of conscientious autonomy as onepromising pathway to circumvent both the limitations and adverse effectsof the dominance of current (mis)understandings of autonomy in biomedical ethics. PMID:27124963

  13. [Analytical chemistry in works of Maria Skłodowska-Curie].

    PubMed

    Hulanicki, Adam

    2012-01-01

    Maria Skłodowska-Curie--a Nobel Prize winner in chemistry--the elements of learning of chemistry gained just by a dint of work of more than ten months in Warsaw in the Institute of Industry and Agriculture Museum. The Nobel Prize concerned a contribution to the progress of chemistry through the discovery of radium and polonium, separation of radium and study of properties of this amazing element. It was awarded for an extremely arduous work, during which the chemical reactions being the principles of analytical chemistry were realized. Unlike to a typical analytical procedure, an initial attempt here was the thousands of kilograms of uranium ore: pitchblende. The final effect was small amounts of new elements: polonium and radium. Both the knowledge and the intuition of the researcher let her have a triumph. The difficulties she experienced because the properties of the searched chemical elements could only be evaluated thanks to the knowledge on other chemical elements. A significant achievement was the determination of the samples by means of radioactivity measurement, which gave rise to radiochemical analytical methods. An extreme analytical precision was demanded in multiple processes of fractional crystallization and precipitation which finally led to the calculation of the atomic mass of radium. PMID:22849241

  14. Sexual excitement.

    PubMed

    Stoller, R J

    1976-08-01

    Sexual excitement depends on a scenario the person to be aroused has been writing since childhood. The story is an adventure, an autobiography disguised as fiction, in which the hero/heroine hides crucial intrapsychic conflicts, mysteries, screen memories of actual traumatic events and the resolution of these elements into a happy ending, best celebrated by orgasm. The function of the fantasy is to take these painful experiences and convert them to pleasure-triumph. In order to sharpen excitement-the vibration between the fear of original traumas repeating and the hope of a pleasurable conclusion this time-one introduces into the story elements of risk (approximations of the trauma) meant to prevent boredom and safety factors (sub-limnal signals to the storyteller that the risk are not truly dangerous). Sexual fantasy can be studied by means of a person's daydreams (including those chosen in magazines, books, plays, television, movies, and outright pornography), masturbatory behavior, object choice, foreplay, techniques of intercourse, or postcoital behavior.

  15. A limited positioning system for memory.

    PubMed

    Shapiro, Matthew

    2015-06-01

    The 2014 Nobel Prize for Physiology or Medicine is an enormous triumph for John O'Keefe and May-Britt and Edvard Moser and an historic event for cognitive and behavioral neuroscience. Neuronal representations decoded from action potentials form a mechanistic bridge between brain and mind and demonstrate the continuity of psychology with biology and physical science. The cognitive map theory powered an ongoing, international research program inspired by Hebb (The Organization of Behavior. New York, NY: Wiley) that showed the way toward linking specific patterns of neuronal activity to high level representation and processing. The prize celebrates a path that led from fundamental, philosophical questions about psychological space to enduring, scientific facts: place, head direction, grid, and boundary fields in the hippocampus, presubiculum, entorhinal cortex, and other brain circuits provide a cellular basis for spatial behavior, learning, and memory. By awarding this prize, the Nobel committee affirmed neuroethology and comparative psychology, marked the end of a chapter in one debate about the existence of animal cognition, and recognized cognitive neurophysiology. The "inner GPS" in the brain" demonstrates "a cellular basis for higher cognitive function." Animals represent, process, and use information defined by abstract relationships among items (O'Keefe and Conway,) to guide flexible, goal-directed actions. Beyond raising the ontological status of "animal mind," the committee agreed that abstract mental representations can be investigated rigorously by recording single unit activity in the brain of behaving animals. PMID:25800503

  16. Chronic myeloid leukemia: reminiscences and dreams.

    PubMed

    Mughal, Tariq I; Radich, Jerald P; Deininger, Michael W; Apperley, Jane F; Hughes, Timothy P; Harrison, Christine J; Gambacorti-Passerini, Carlo; Saglio, Giuseppe; Cortes, Jorge; Daley, George Q

    2016-05-01

    With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people's lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman.

  17. Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants

    PubMed Central

    Gagliano, Sarah A.; Ravji, Reena; Barnes, Michael R.; Weale, Michael E.; Knight, Jo

    2015-01-01

    Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, statistical learning has been widely investigated for prioritizing genetic variants likely to be associated with complex disease. We compared three published prioritization procedures, which use different statistical learning algorithms and different predictors with regard to the quantity, type and coding. We also explored different combinations of algorithm and annotation set. As an application, we tested which methodology performed best for prioritizing variants using data from a large schizophrenia meta-analysis by the Psychiatric Genomics Consortium. Results suggest that all methods have considerable (and similar) predictive accuracies (AUCs 0.64–0.71) in test set data, but there is more variability in the application to the schizophrenia GWAS. In conclusion, a variety of algorithms and annotations seem to have a similar potential to effectively enrich true risk variants in genome-scale datasets, however none offer more than incremental improvement in prediction. We discuss how methods might be evolved for risk variant prediction to address the impending bottleneck of the new generation of genome re-sequencing studies. PMID:26300220

  18. Lewis Wolpert discusses development and depression. Interview by Joanne Clough.

    PubMed

    Wolpert, Lewis

    2004-06-01

    Lewis Wolpert is Professor of Biology as Applied to Medicine in the Department of Anatomy and Developmental Biology at University College, London, UK. His research interests focus on the mechanisms that are involved in embryonic development. Lewis originally trained as a civil engineer in South Africa but in 1955 made the move to research in cellular biology at King's College, London. He was made a Fellow of the Royal Society in 1980 and awarded the CBE in 1990. Lewis was also made a Fellow of the Royal Society of Literature in 1999 and has presented science on both radio and TV for several years. He was awarded The Royal Society Michael Faraday Prize in 2000 for his contribution to the public understanding of science, most notably through his Chairmanship of the Committee for the Public Understanding of Science (COPUS; 1993-1998). He is the author of numerous books, including Malignant Sadness: The Anatomy of Depression, Principles of Development, The Unnatural Nature of Science and The Triumph of the Embryo. He also writes a regular column for The Independent.

  19. Perceptions of teaching African American students who succeed during science testing: A hermeneutic phenomenological study

    NASA Astrophysics Data System (ADS)

    Harris, Tevis Tramaine

    The purpose of this hermeneutic phenomenological research was to explore the perceptions of teachers as they instruct African American students who are successful on the North Carolina End-of-Grade Science test. The study identified thoughts, feelings, emotions, and challenges that teachers faced when instructing successful African American students from Title I schools in rural community classrooms. The research study analysis utilized NVivo10RTM software and identified common themes in the data. Five themes emerged from interviews with five fifth- and eighth-grade science teachers. Based on the teachers' perceptions, the findings revealed: (a) teachers experience an emotional journey in high poverty schools; (b) investments encompass sacrificing whatever is needed to help students become successful; (c) relationships should be developed between the teacher and student; (d) intentionality is a part of teachers' daily interaction with students; and (e) teachers encounter a challenging opportunity instructing African American students in science. This study provides valuable data in understanding the experiences of teachers as they instruct successful African American students and the challenges, obstacles, and triumphs teachers face when working with this population of students. The implications of the study suggest that educational leaders provide emotional support to help teachers manage the plethora of emotions experienced on a daily basis. Future study of successful teachers of African American students may further inform the dearth of literature surrounding the experience of successful teachers of minority students.

  20. Early American Strabismus Surgery: 1840-1845.

    PubMed

    Currie, Benjamin D; Feibel, Robert M

    2015-01-01

    The discovery of effective surgical therapy for strabismus was one of the outstanding triumphs of the first half of 19th-century ophthalmology, just prior to the invention of the ophthalmoscope in 1850. Although priority for the development of strabismus surgery belongs to Johann Friedrich Dieffenbach of Germany, who first reported his surgical results in 1839, 4 cases of tenotomy of the medial rectus muscle had been performed in the United States by William Gibson in 1818 but never published. By 1840, the reports of surgery in Europe had rapidly spread to America where surgeons immediately began using these procedures. The first American surgeon to perform eye muscle surgery and publish his results was John Dix of Boston, and other surgeons were soon reporting their cases as well. We discuss 8 American pioneers in this field during the time (1840-1845) of the first burst of enthusiasm for this surgery. Although these surgeons were active in performing a large number of cases and carefully reporting their experiences and results, they did not make any major advances in the field. PMID:26669424

  1. Superfluid 3He—the Early Days

    NASA Astrophysics Data System (ADS)

    Lee, D. M.; Leggett, A. J.

    2011-08-01

    A history is given of liquid 3He research from the time when 3He first became available following World War II through 1972 when the discovery of the superfluid phases was made. The Fermi liquid nature was established early on, and the Landau Fermi liquid theory provided a framework for understanding the interactions between the Fermions (quasiparticles). The theory's main triumph was to predict zero sound, which was soon discovered experimentally. Experimental techniques are treated, including adiabatic demagnetization, dilution refrigerator technology, and Pomeranchuk cooling. A description of the superfluid 3He discovery experiments using the latter two of these techniques is given. While existing theories provided a basis for understanding the newly discovered superfluid phases in terms of ℓ>0 Cooper pairs, the unexpected stability of the A phase in the high- P, high- T region of the phase diagram needed for its explanation a creative leap beyond the BCS paradigm. The use of sum rules to interpret some of the unusual magnetic resonance in liquid 3He is discussed. Eventually a complete theory of the spin dynamics of superfluid 3He was developed, which predicted many of the exciting phenomena subsequently discovered.

  2. Molecular characterization of two lipoxygenases from barley.

    PubMed

    van Mechelen, J R; Schuurink, R C; Smits, M; Graner, A; Douma, A C; Sedee, N J; Schmitt, N F; Valk, B E

    1999-04-01

    Two full-length lipoxygenase cDNA sequences (LoxB and LoxC) from barley (Hordeum distichum cv. L. Triumph) are described. The cDNAs share high homology with the barley LoxA cDNA. Southern blotting experiments indicate single copy numbers of the three lipoxygenase genes. RFLP mapping revealed the presence of single lipoxygenase loci. LoxA and LoxB map on chromosome 4 and LoxC on chromosome 7. Two isoenzymes, LOX1 and LOX2, have been purified previously from germinating barley and characterized. LOX1 is encoded by LoxA, while LOX2 is encoded by LoxC. The product related to the third cDNA (loxB) has not been identified so far, suggesting a low protein abundance for the corresponding isoform in barley. Transcripts corresponding with these LOX genes are predominantly observed in grain and in seedling, whereas transcripts corresponding to LoxB and LoxC are also observed in mature vegetative tissue. No lipoxygenase mRNA could be detected in aleurone layer of germinating grain. No significant differences in lipoxygenase mRNA levels were observed in developing grains grown under dormant or non-dormant conditions, suggesting that LOX is not directly involved in induction of grain dormancy.

  3. Some reflections on a case of mother/adolescent son incest.

    PubMed

    Shengold, L

    1980-01-01

    A rare case of mother/adolescent son incest is presented. The son, treated in analysis, was not psychotic. Questions are raised about why father/daughter incest appears to be much more common than mother/son incest. Part of the answer, I speculate, has to do with the special psychic dangers for both mother and son, perhaps phylogenetically-based, which attach to the fantasy and the possibility of impregnating the mother. Where the incest taboo is violated, the primary responsibility would appear to be the parent's; the parent is frequently motivated by a compulsion to repeat his or her own incestuous past. In the case presented the probably psychotic mother had raised her son to look like a girl for several years, and he had been the victim of a homosexual assault at the age of 6. The incest at puberty seems to have helped him reverse a psychic position of subjection to the pre-oedipal mother, to have modified his rage and reinforced his masculinity. It also produced some of the arrogance, alongside a need for failure and punishment that evoke the legend of Oedipus. The mother, fearful of the possibility of getting pregnant, had abruptly stopped the incest. It had been repressed, and became conscious again when the son entered analysis. He then left his treatment without being able to work through much of the terror consequent to the consummation of incest, and with some of the feeling of oedipal triumph retained.

  4. Dean Milton C. Winternitz at Yale.

    PubMed

    Spiro, Howard; Norton, Priscilla Waters

    2003-01-01

    Milton Winternitz led Yale Medical School as its Dean from 1920 to 1935. An innovative, even maverick leader, he not only kept the school from going under, but turned it into a first-class research institution. Dedicated to the new scientific medicine established in Germany, he was equally fervent about "social medicine" and the study of humans in their culture and environment. He established the "Yale System" of teaching, with few lectures and fewer exams, and strengthened the full-time faculty system; he also created the graduate-level Yale School of Nursing and the Psychiatry Department, built numerous new buildings, and much more. It is a loss to 21st-century medicine that his dream of an Institute of Human Relations, envisioned as a refuge where social scientists would collaborate with biological scientists in a holistic study of humankind, lasted for only a few years, before falling victim to the more obvious triumphs of medical science and technology. It is sad, too, that he is remembered largely as a Jew presiding over a medical school that, like most others, restricted the number of Jewish students, rather than for his contributions to American medicine.

  5. When voices get emotional: a corpus of nonverbal vocalizations for research on emotion processing.

    PubMed

    Lima, César F; Castro, São Luís; Scott, Sophie K

    2013-12-01

    Nonverbal vocal expressions, such as laughter, sobbing, and screams, are an important source of emotional information in social interactions. However, the investigation of how we process these vocal cues entered the research agenda only recently. Here, we introduce a new corpus of nonverbal vocalizations, which we recorded and submitted to perceptual and acoustic validation. It consists of 121 sounds expressing four positive emotions (achievement/triumph, amusement, sensual pleasure, and relief) and four negative ones (anger, disgust, fear, and sadness), produced by two female and two male speakers. For perceptual validation, a forced choice task was used (n = 20), and ratings were collected for the eight emotions, valence, arousal, and authenticity (n = 20). We provide these data, detailed for each vocalization, for use by the research community. High recognition accuracy was found for all emotions (86 %, on average), and the sounds were reliably rated as communicating the intended expressions. The vocalizations were measured for acoustic cues related to temporal aspects, intensity, fundamental frequency (f0), and voice quality. These cues alone provide sufficient information to discriminate between emotion categories, as indicated by statistical classification procedures; they are also predictors of listeners' emotion ratings, as indicated by multiple regression analyses. This set of stimuli seems a valuable addition to currently available expression corpora for research on emotion processing. It is suitable for behavioral and neuroscience research and might as well be used in clinical settings for the assessment of neurological and psychiatric patients. The corpus can be downloaded from Supplementary Materials.

  6. Eggs-ploiting women: a critical feminist analysis of the different principles in transplant and fertility tourism.

    PubMed

    Pfeffer, Naomi

    2011-11-01

    Intergovernmental agencies have recognized that inconsistencies in the way that nation states regulate commerce in human kidneys lubricate transplant tourism, and have repeatedly exhorted recalcitrant governments of both organ-importing and organ-exporting nations to criminalize the exchange of cash for kidneys. Yet these same organizations have elected to remain silent on inconsistencies in the regulation of the trade in human eggs that lubricate fertility tourism. This article is a critical feminist analysis of this paradox. Sketches of the histories of regulation of the global markets in human kidneys and human eggs allow attribution of the different approaches to sales of kidneys and eggs to the triumph of neo-liberalism in the 1990s. Neo-liberalism supports the growth of the medical tourism industry and its niche market catering for infertility, and is responsible for exacerbating the relative disadvantage of poor and powerless women in destination countries, thereby creating the conditions for 'bioavailability', that is, the willingness to exchange body parts for cash. The paper identifies a disturbing correlation between deeply engrained conservative attitudes to women and a plentiful supply of eggs, and concludes by suggesting that what women need to lift themselves out of poverty and discrimination is secure and dignified work.

  7. Positioning advanced practice registered nurses for health care reform: consensus on APRN regulation.

    PubMed

    Stanley, Joan M; Werner, Kathryn E; Apple, Kathy

    2009-01-01

    Advanced practice registered nurses (APRNs) have positioned themselves to serve an integral role in national health care reform. This article addresses both the policy and the process to develop this policy that has placed them in a strategic position. A successful transformation of the nation's health system will require utilization of all clinicians, particularly primary care providers, to the full extent of their education and scope of practice. APRNs are highly qualified clinicians who provide cost-effective, accessible, patient-centered care and have the education to provide the range of services at the heart of the reform movement, including care coordination, chronic care management, and wellness and preventive care. The APRN community faces many challenges amidst the opportunities of health reform. However, the APRN community's triumph in reaching consensus on APRN regulation signifies a cohesive approach to overcoming the obstacles. The consensus model for APRN regulation, endorsed by 44 national nursing organizations, will serve as a beacon for nursing, as well as a guidepost for consumers and policymakers, on titling, education, certification, accreditation, and licensing for all four APRN roles.

  8. Organizing for empowerment: an interview with AES's Roger Sant and Dennis Bakke. Interview by Suzy Wetlaufer.

    PubMed

    Sant, R; Bakke, D

    1999-01-01

    The topic of empowerment is receiving a lot of attention, but how many employees are truly empowered? At the global electricity giant AES Corporation, the answer is all 40,000 of them. In this interview, chairman Roger Sant and CEO Dennis Bakke reflect on their trials and triumphs in creating an exceptional company and explain how their employee-run company works. When they founded AES in 1981, Sant and Bakke set out to create a company where people could have engaging experiences on a daily basis--a company that embodied the principles of fairness, integrity, social responsibility, and fun. Putting those principles into action has created something unique--an ecosystem of real empowerment. What does that system look like? Rather than having a traditional hierarchical chain of command, AES is organized around small teams that are responsible for operations and maintenance. Moreover, AES has eliminated functional departments; there's no corporate marketing division or human resources department. For the system to work, every person must become a well-rounded generalist--a mini-CEO. That, in turn, redefines the jobs of the people at headquarters. Instead of setting strategy and making the "the big decisions," Sant and Bakke act as advisers, guardians of the principles, accountability officers, and chief encouragers. Can other companies successfully adopt the mechanics of such a system? Not unless they first adopt the shared principles that have guided AES since its inception. "Empowerment without values isn't empowerment," says Sant. "It's just technique," adds Bakke.

  9. Stapp's quantum dualism: The James and Heisenberg model of consciousness

    NASA Astrophysics Data System (ADS)

    Noyes, H. P.

    1994-02-01

    Henry Stapp attempts to resolve the Cartesian dilemma by introducing what the author would characterize as an ontological dualism between mind and matter. His model for mind comes from William James' description of conscious events and for matter from Werner Heisenberg's ontological model for quantum events (wave function collapse). His demonstration of the isomorphism between the two types of events is successful, but in the author's opinion fails to establish a monistic, scientific theory. The author traces Stapp's failure to his adamant rejection of arbitrariness, or 'randomness.' This makes it impossible for him (or for Bohr and Pauli before him) to understand the power of Darwin's explanation of biology, let alone the triumphs of modern 'neo-Darwinism.' The author notes that the point at issue is a modern version of the unresolved opposition between Leucippus and Democritus on one side and Epicurus on the other. Stapp's views are contrasted with recent discussions of consciousness by two eminent biologists: Crick and Edelman. They locate the problem firmly in the context of natural selection on the surface of the earth. Their approaches provide a sound basis for further scientific work. The author briefly examines the connection between this scientific (rather than ontological) framework and the new fundamental theory based on bit-strings and the combinatorial hierarchy.

  10. Influence of soil properties and soil leaching on the toxicity of ionic silver to plants.

    PubMed

    Langdon, Kate A; McLaughlin, Mike J; Kirby, Jason K; Merrington, Graham

    2015-11-01

    Silver (Ag) has been shown to exhibit antimicrobial properties; as a result, it is being used increasingly in a wide range of consumer products. With these uses, the likelihood that Ag may enter the environment has increased, predominately via land application of biosolids or irrigation with treated wastewater effluent. The aim of the present study was to investigate the toxicity of Ag to 2 plant species: barley (Hordeum vulgare L. CV Triumph) and tomato (Lycopersicum esculentum) in a range of soils under both leached and unleached conditions. The concentrations that resulted in a 50% reduction of plant growth (EC50) were found to vary up to 20-fold across the soils, indicating a large influence of soil type on Ag toxicity. Overall, barley root elongation was found to be the least sensitive to added Ag, with EC50 values ranging from 51 mg/kg to 1030 mg/kg, whereas the tomato plant height showed higher sensitivity with EC50 values ranging from 46 mg/kg to 486 mg/kg. The effect of leaching was more evident in the barley toxicity results, where higher concentrations of Ag were required to induce toxicity. Variations in soil organic carbon and pH were found to be primarily responsible for mitigating Ag toxicity; therefore, these properties may be used in future risk assessments for Ag to predict toxicity in a wide range of soil types.

  11. Jointly They Edit: Examining the Impact of Community Identification on Political Interaction in Wikipedia

    PubMed Central

    Neff, Jessica J.; Laniado, David; Kappler, Karolin E.; Volkovich, Yana; Aragón, Pablo; Kaltenbrunner, Andreas

    2013-01-01

    Background In their 2005 study, Adamic and Glance coined the memorable phrase ‘divided they blog’, referring to a trend of cyberbalkanization in the political blogosphere, with liberal and conservative blogs tending to link to other blogs with a similar political slant, and not to one another. As political discussion and activity increasingly moves online, the power of framing political discourses is shifting from mass media to social media. Methodology/Principal Findings Continued examination of political interactions online is critical, and we extend this line of research by examining the activities of political users within the Wikipedia community. First, we examined how users in Wikipedia choose to display their political affiliation. Next, we analyzed the patterns of cross-party interaction and community participation among those users proclaiming a political affiliation. In contrast to previous analyses of other social media, we did not find strong trends indicating a preference to interact with members of the same political party within the Wikipedia community. Conclusions/Significance Our results indicate that users who proclaim their political affiliation within the community tend to proclaim their identity as a ‘Wikipedian’ even more loudly. It seems that the shared identity of ‘being Wikipedian’ may be strong enough to triumph over other potentially divisive facets of personal identity, such as political affiliation. PMID:23573269

  12. For the love of love: neoliberal governmentality, neoliberal melancholy, critical intersectionality, and the advent of solidarity with the other Mormons.

    PubMed

    Lee, Wenshu

    2012-01-01

    This article performs critical intellectual labor for social and political change against neoliberalism in three ways. First, it explores and connects neoliberal governmentality and neoliberal melancholy, two anchor experiences in our twenty-first century political quotidian. Second, it engages in the sense making of Proposition 8 (a California voter initiative to ban same-sex marriage, which was narrowly passed in 2008) as a case study of religious organizations (the Mormon Church and their religious allies) and their complicity with neoliberal states to foster subjection and subjectivation through critical intersectionality that goes beyond the identity trinity of race, class, and gender. Finally, the article suggests two technologies as a new hand to outplay the excess of neoliberalism for the triumph of our common humanity: 1) mourning over the devastation brought about by neoliberalism and 2) loving our love for those with whom we usually do not form affinity connections, such as the other Mormons, those who are othered because of their departure from church orthodoxy. PMID:22925052

  13. [On the psychoanalytic view of Harry Potter].

    PubMed

    Subkowski, Peter

    2008-01-01

    This paper analyzes the exemplary mental development that Harry Potter undertakes after the massive traumatic loss of his parents at the early age of 15 months and the following neglect by his relatives until he becomes a mature adult. On the basis of his internalized mothers love and by identification with his father and his paternally friend Dumbledore Harry gains increasing self-confidence and new friends in his peer group in the course of time. After passing numerous conflicts and experiencing friendship Harry reaches the stage of initiation into the world of the adults. On the oedipal level he finally is able to deidealize his father and Dumbledore. And at the end Harry is not seduced by absolute power and the triumph over death itself. On the contrary he is ready to sacrifice himself for his friends and thus can overcome the fragmented Voldemort. Readers can identify with Harry, can recognize their own experiences and conflicts and can deal with the proposed conflict resolution patterns on different levels. This contemporary "Bildungsroman" deals with important typical interpersonal and cultural issues for young people. This is what leads young readers to strong resonance and identification processes and explains the great success of the Harry Potter story. PMID:18924532

  14. Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS).

    PubMed

    Simirgiotis, Mario J; Quispe, Cristina; Bórquez, Jorge; Areche, Carlos; Sepúlveda, Beatriz

    2016-01-15

    A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data (UHPLC-PDA-HESI-orbitrap-MS/MS). In addition, the antioxidant features of the fruits were compared with the varieties Packhman's Triumph and Abate Fetel and correlated with the presence of phenolic compounds. The non-pigmented phenolics were fingerprinted and related to the antioxidant capacities measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and total content of phenolics and flavonoids measured by spectroscopic methods. The machine allowed a fast separation of 15 min employing a flow rate of 1 mL per minute and could accurately identify 25 compounds, including several isorhamnetin derivatives and phenolic acids, present in the peel and pulps of this Chilean variety for the first time. The compounds were monitored using a wavelength range of 210-800 nm. The native small Chilean pear showed the highest antioxidant activity measured as the bleaching of the DPPH radical, the ferric reducing antioxidant power and superoxide anion scavenging activity (8.61 ± 0.65 μg/mL, 712.63 ± 12.12 micromols trolox equivalents (μmol/TE)/100 g FW, and 82.89% ± 2.52% at 100 μg/mL, respectively).

  15. When should a leader apologize and when not?

    PubMed

    Kellerman, Barbara

    2006-04-01

    When corporate leaders or the organizations they represent mess up, they face the difficult decision of whether or not to apologize publicly. A public apology is a risky move. It's highly political, and every word matters. Refusal to apologize can be smart, or it can be suicidal. Readiness to apologize can be seen as a sign of character or one of weakness. A successful apology can turn enmity into personal and organizational triumph--while an apology that's too little, too late, or too transparently tactical can open the floodgates to individual and institutional ruin. Since the stakes are so high, Kellerman says, leaders should not extend public apologies often or lightly. One or more of the following conditions should apply: The apology is likely to serve an important purpose. The offense is of serious consequence. It's appropriate that the leader assume responsibility for the offense. The leader is the only one who can get the job done. The cost of saying something is likely lower than the cost of staying silent. The author draws her conclusions from hard data and abundant anecdotal evidence, examining notoriously bad apologizers as well as exceptionally good ones. While selectivity is key, good apologies usually do work. What constitutes a good apology? Acknowledgment of the mistake or wrongdoing, acceptance of responsibility, expression of regret, and assurance that the offense will not be repeated. PMID:16579415

  16. Cardiac Surgery

    PubMed Central

    Weisse, Allen B.

    2011-01-01

    Well into the first decades of the 20th century, medical opinion held that any surgical attempts to treat heart disease were not only misguided, but unethical. Despite such reservations, innovative surgeons showed that heart wounds could be successfully repaired. Then, extracardiac procedures were performed to correct patent ductus arteriosus, coarctation of the aorta, and tetralogy of Fallot. Direct surgery on the heart was accomplished with closed commissurotomy for mitral stenosis. The introduction of the heart-lung machine and cardiopulmonary bypass enabled the surgical treatment of other congenital and acquired heart diseases. Advances in aortic surgery paralleled these successes. The development of coronary artery bypass grafting greatly aided the treatment of coronary heart disease. Cardiac transplantation, attempts to use the total artificial heart, and the application of ventricular assist devices have brought us to the present day. Although progress in the field of cardiovascular surgery appears to have slowed when compared with the halcyon times of the past, substantial challenges still face cardiac surgeons. It can only be hoped that sufficient resources and incentive can carry the triumphs of the 20th century into the 21st. This review covers past developments and future opportunities in cardiac surgery. PMID:22163121

  17. Eggs-ploiting women: a critical feminist analysis of the different principles in transplant and fertility tourism.

    PubMed

    Pfeffer, Naomi

    2011-11-01

    Intergovernmental agencies have recognized that inconsistencies in the way that nation states regulate commerce in human kidneys lubricate transplant tourism, and have repeatedly exhorted recalcitrant governments of both organ-importing and organ-exporting nations to criminalize the exchange of cash for kidneys. Yet these same organizations have elected to remain silent on inconsistencies in the regulation of the trade in human eggs that lubricate fertility tourism. This article is a critical feminist analysis of this paradox. Sketches of the histories of regulation of the global markets in human kidneys and human eggs allow attribution of the different approaches to sales of kidneys and eggs to the triumph of neo-liberalism in the 1990s. Neo-liberalism supports the growth of the medical tourism industry and its niche market catering for infertility, and is responsible for exacerbating the relative disadvantage of poor and powerless women in destination countries, thereby creating the conditions for 'bioavailability', that is, the willingness to exchange body parts for cash. The paper identifies a disturbing correlation between deeply engrained conservative attitudes to women and a plentiful supply of eggs, and concludes by suggesting that what women need to lift themselves out of poverty and discrimination is secure and dignified work. PMID:21945266

  18. Growing pains of East Timor: health of an infant nation.

    PubMed

    Morris, K

    2001-03-17

    In August, 1999, three-quarters of East Timorese adults voted to end more than two decades of an Indonesian administration never recognised by the United Nations. The ensuing spree of violence and destruction by militia backed by the Indonesian military meant the birth of the fledgling nation became a complex humanitarian disaster. 1 year on, progress was heartening: a transitional government, a judiciary, and tax systems were in place, and East Timor was a proud competitor in the Sydney Olympic games. Rebuilding a country from ground level has brought a golden opportunity for fresh approaches. However, reconstruction is also a slow, complex, and sometimes controversial process at the mercy of multiple agendas. The health sector has seen basic care restored, establishment of a much-needed public-health service, and planning for the future health system. An innovative partnership between WHO/Roll Back Malaria and Merlin for post-conflict research has provided data to guide malaria control. The story of progress from humanitarian emergency to national health plan epitomises the triumphs and challenges of this newest nations' first 18 months.

  19. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease.

    PubMed

    Selkoe, Dennis J

    2007-12-01

    A remarkable rise in life expectancy during the past century has made Alzheimer's disease (AD) the most common form of progressive intellectual failure in humans. Patients with AD lose their most human qualities-reasoning, abstraction, language, and memory. The brain plaques that Alois Alzheimer first described 100 years ago have inspired the search for genetic alterations that underlie AD. Four genes have been unequivocally implicated to date in inherited forms of AD, where mutations or natural variations in these genes cause excessive accumulation of the amyloid beta-protein, the building block of amyloid plaques. This aggregation leads to subsequent neuronal degeneration in brain regions important for memory and cognition. The discovery of the genes involved in the mechanisms of amyloid beta-protein build-up in AD, coupled with cell culture and animal models of their involved pathways, has led to the development of specific pharmacological strategies to lower amyloid beta-protein levels as a way of treating or preventing all forms of the disease. While hard work lies ahead, the movement from basic research to the clinic in AD represents a triumph of reductionist biology applied to the most complex of all biological systems, the human cerebral cortex.

  20. Transition to space - A history of 'space plane' concepts at Langley Aeronautical Laboratory 1952-1957

    NASA Technical Reports Server (NTRS)

    Hansen, James R.

    1987-01-01

    The supersonic speeds of X-series aircraft and wind tunnel data in the early 1950s demonstrated that hypersonic flight was an achievable goal. A blunt-nosed vehicle was found to form a bow shock that deflected much of the heating an aircraft would otherwise experience at high speeds. It was felt that critical aspects of hypersonic flight, e.g., aerodynamic performance and heating, controllability, etc., could not be fully explored in wind tunnels. The X-15 project was initiated by NASA in 1954 to produce a vehicle capable of Mach 7 flight to altitudes that would permit short evaluations of human performance in microgravity. Design tradeoffs examined in the program are discussed, with emphasis on lifting bodies and winged vehicles with high L/D ratios. Political pressures created by the public triumph of the Sputnik in 1958 removed much of the impetus for development of a manned spaceplane, and long-term goals that eventually led to the Shuttle were delayed by a short-term program oriented toward ballistic manned capsules.

  1. Testing QCD in the non-perturbative regime

    SciTech Connect

    A.W. Thomas

    2007-01-01

    This is an exciting time for strong interaction physics. We have a candidate for a fundamental theory, namely QCD, which has passed all the tests thrown at it in the perturbative regime. In the non-perturbative regime it has also produced some promising results and recently a few triumphs but the next decade will see enormous progress in our ability to unambiguously calculate the consequences of non-perturbative QCD and to test those predictions experimentally. Amongst the new experimental facilities being constructed, the hadronic machines at JPARC and GSI-FAIR and the 12 GeV Upgrade at Jefferson Lab, the major new electromagnetic facility worldwide, present a beautifully complementary network aimed at producing precise new measurements which will advance our knowledge of nuclear systems and push our ability to calculate the consequences of QCD to the limit. We will first outline the plans at Jefferson Lab for doubling the energy of CEBAF. The new facility presents some wonderful opportunities for discovery in strong interaction physics, as well as beyond the standard model. Then we turn to the theoretical developments aimed at extracting precise results for physical hadron properties from lattice QCD simulations. This discussion will begin with classical examples, such as the mass of the nucleon and ?, before dealing with a very recent and spectacular success involving information extracted from modern parity violating electron scattering.

  2. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    PubMed Central

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-01-01

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. Our results point at a large Fermi surface consistent with Luttinger’s theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition. PMID:27174799

  3. Ben Franklin: A Curiosity-Driven Scientist, a Service-Driven Citizen

    NASA Astrophysics Data System (ADS)

    Herschbach, Dudley

    2003-04-01

    At the age of 42, Franklin retired from his prosperous printing business, ``to have leisure to read, study, and make experiments." The scope of his scientific work was remarkable. Beyond his key contributions to understanding electrcity, Franklin wrote major papers on population growth, on meterology, on heat conduction and evaporation, charted the Gulf Stream, studied bioluminescence and the stilling of water waves by a surface layer of oil. He also advanced arguments in favor of conservation of mass and the wave theory of light. Although always alert for practical applications, his style was that of an explorer, eager for adventure and insight. However, Franklin did not consider science as important as public service. He promoted many civic projects in Philadelphia, including a circulating library, fire department, paving of streets, hospital, and was the prime mover in founding the American Philosophical Society and an academy that evolved into the University of Pennsylvania. As well as publishing the most widely read newspaper in the colonies and his bestselling almanac, he became public printer for several of the colonies and postmaster. He lived in England 14 years as a trade representative, largely struggling in vain. At the age of 70, he undertook a decade of service as minister to France, achieving against great odds crucial diplomatic triumphs.

  4. An expedition to heal the wounds of war. The 1919 eclipse and Eddington as Quaker adventurer

    NASA Astrophysics Data System (ADS)

    Stanley, Matthew

    2003-03-01

    The 1919 eclipse expedition's confirmation of general relativity is often celebrated as a triumph of scientific internationalism. However, British scientific opinion during World War I leaned toward the permanent severance of intellectual ties with Germany. That the expedition came to be remembered as a progressive moment of internationalsm was largely the result of the efforts of A. S. Eddington. A devout Quaker, Eddington imported into the scientific community the strategies being used by his coreligionists in the national dialogue: humanize the enemy through personal contact and dramatic projects that highlight the value of peace and cooperation. The essay also addresses the common misconception that Eddington's sympathy for Einstein led him intentionally to misinterpret the expedition's results. The evidence gives no reason to think that Eddington or his coworkers were anything but rigorous. Eddington's pacifism is reflected not in manipulated data but in the meaning of the expedition and the way it entered the collective memory as a celebration of international cooperation in the wake of war.

  5. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts.

    PubMed

    Simmons, Jane Ellen; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Rice, Glenn; Schenck, Kathleen M; Hunter, E Sidney; Teuschler, Linda K

    2002-12-01

    Chemical disinfection of water is a major public health triumph of the 20th century. Dramatic decreases in both morbidity and mortality of waterborne diseases are a direct result of water disinfection. With these important public health benefits comes low-level, chronic exposure to a very large number of disinfection byproducts (DBPs), chemicals formed through reaction of the chemical disinfectant with naturally occurring inorganic and organic material in the source water. This article provides an overview of joint research planning by scientists residing within the various organizations of the U.S. Environmental Protection Agency Office of Research and Development. The purpose is to address concerns related to potential health effects from exposure to DBPs that cannot be addressed directly from toxicological studies of individual DBPs or simple DBP mixtures. Two factors motivate the need for such an investigation of complex mixtures of DBPs: a) a significant amount of the material that makes up the total organic halide and total organic carbon portions of the DBPs has not been identified; and b) epidemiologic data, although not conclusive, are suggestive of potential developmental, reproductive, or carcinogenic health effects in humans exposed to DBPs. The plan is being developed and the experiments necessary to determine the feasibility of its implementation are being conducted by scientists from the National Health and Environmental Effects Research Laboratory, the National Risk Management Research Laboratory, the National Exposure Research Laboratory, and the National Center for Environmental Assessment. PMID:12634133

  6. Prospects for delaying the rising tide of worldwide, late-life dementias.

    PubMed

    Larson, Eric B

    2010-12-01

    Worldwide, lifespan is lengthening. Concomitantly, late-life dementias are increasingly common, challenging both personal and public health internationally. After age 65, rates of dementia tend to double every five years in developed countries and every seven in developing ones. The late-life dementias, particularly Alzheimer's disease, have profound effects on aging individuals and their caregivers. Multidisciplinary research has explored the potential for various approaches to prevent or delay the onset of late-life dementias. Outlining that research, including our team's Adult Changes in Thought and Kame studies, this review concludes that delaying the onset of these dementias appears feasible, although absolute prevention may not be. Today, the most promising methods appear to include controlling vascular risk factors like hypertension and engaging in physical exercise - and possibly mental exercise. If people can delay the onset of dementias, they can lead more fulfilling lives for longer, spending less time suffering from dementia and letting their families spend less time coping with the disease. It is possible that trends toward more knowledge-based societies, where cognitive health is so vital, may increasingly exert evolutionary pressure favoring larger and healthier brains - and a "compression of cognitive morbidity" - well into old age. Public health's great triumph, increased lifespan, should give more of the world's people the reward of many years of dementia-free life. Rather than the personal difficulties and public health burdens of many years of functional impairment, dependency, and suffering with dementia, some interventions may delay the onset of Alzheimer's disease and other dementias.

  7. [The power of the health system and situation of the individual].

    PubMed

    Lunheim, R

    1991-12-10

    The article discusses the power of the medical profession and the welfare state in relation to individual health and privacy. It is argued that the increasing power of the profession and social welfare entails a threat to the individual as a master of his own health and life. Modern medicine emerged from widespread disrepute in the 19th century into Messianic enthusiasm caused by aweinspiring therapeutic triumphs at the turn of the century. Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health. The definition of health as "complete physical, social and mental wellbeing", and a lack of recognition of suffering as an essential part of human life, are conceived to be totalitarian wolf in the sheep's clothing of welfare. The efficacy of medicine depends on sensible management of the medical profession as a charismatic status. The medical profession has a necessary element of "conspiracy" which is particularly difficult to maintain in the egalitarian culture of Norway. Additional harm is done through extensive misuse of medical authority in dispensing welfare benefits.

  8. Heme Oxygenase-1: A Metabolic Nike

    PubMed Central

    Nemeth, Zsuzsanna; Correa-Costa, Matheus; Bulmer, Andrew C.; Otterbein, Leo E.

    2014-01-01

    Abstract Significance: Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. Recent Advances: The heme oxygenases (HO) are metabolic enzymes that utilize NADPH and oxygen to break apart the heme moiety liberating biliverdin (BV), carbon monoxide (CO), and iron. Heme that is derived from hemoproteins can be toxic to the cells and if not removed immediately, it causes cell apoptosis and local inflammation. Elimination of heme from the milieu enables generation of three products that influences numerous metabolic changes in the cell. Critical Issues: CO has profound effects on mitochondria and cellular respiration and other hemoproteins to which it can bind and affect their function, while BV and bilirubin (BR), the substrate and product of BV, reductase, respectively, are potent antioxidants. Sequestration of iron into ferritin and its recycling in the tissues is a part of the homeodynamic processes that control oxidation-reduction in cellular metabolism. Further, heme is an important component of a number of metabolic enzymes, and, therefore, HO-1 plays an important role in the modulation of cellular bioenergetics. Future Directions: In this review, we describe the cross-talk between heme oxygenase-1 (HO-1) and its products with other metabolic pathways. HO-1, which we have labeled Nike, the goddess who personified victory, dictates triumph over pathophysiologic conditions, including diabetes, ischemia, and cancer. Antioxid. Redox Signal. 20, 1709–1722. PMID:24180257

  9. Skin lighteners, Black consumers and Jewish entrepreneurs in South Africa.

    PubMed

    Thomas, Lynn M

    2012-01-01

    This article considers the rise and decline of South Africa's lucrative and controversial skin-lighteners market through examination of the business history of the largest manufacturers, Abraham and Solomon Krok, and their evolving personas as millionaires and philanthropists. Such examination reveals how the country's skin-lighteners trade emerged as part of the broader growth of a black consumer market after the Second World War and how elements of that market became the target of anti-apartheid protests in subsequent decades. It also demonstrates how the Kroks' experiences as second-generation Jewish immigrants shaped their involvement in the trade and how, later, their self-identification as Jewish philanthropists informed their efforts to rehabilitate their reputations following South Africa's 1990 ban on all skin lighteners. Such efforts include the building of Johannesburg's highly acclaimed Apartheid Museum, modelled after the United States Holocaust Memorial Museum. This article explores the profound ironies that some South Africans see in the fact that a museum dedicated to commemorating those who suffered under and, ultimately, triumphed against state racism was financed by a family fortune generated through the sale of skin lighteners to black consumers. PMID:22830098

  10. The Prime Minister and the platypus: A paradox goes to war.

    PubMed

    Lawrence, Natalie

    2012-03-01

    In February 1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain. This request can only be understood if placed in the context of Churchill's passion for exotic pets as well as the rich history of aristocratic menageries and live diplomatic gifts. Obtaining an animal hitherto unseen alive in Europe would have been a great zoological achievement for London Zoo and secured British authority in heated historical taxonomical debates. This zoological triumph, coupled with accomplishing an extravagant enterprise in the middle of war-time austerity would have boosted public morale. Most importantly, despite its death, the platypus, served as a token for mediating the soured relations between Australia and Britain. Churchill's platypus provides a unique case of animal collecting that incorporates effects on international diplomacy and public relations along with a great private eccentricity and passion.

  11. Superlattice-based quantum devices: from theory to practical applications

    NASA Astrophysics Data System (ADS)

    Razeghi, M.

    2014-07-01

    The concepts of resonant tunneling and superlattices were first developed by Esaki and Tsu. What started with the new physics of the Esaki tunnel diode has matured into nanoscale engineering of semiconductors superlattices to create whole synthetic band structures. While working at Thomson CSF in France, Manijeh Razeghi went on to develop the metal-organic chemical vapor deposition (MOCVD) and molecular beam epitaxy growth of superlattice material as reported in my seminal volumes of The MOCVD Challenge. After years of considerable effort to bring this technology to maturity, we now see the results of this formidable new science in almost every electronic and photonic device that we encounter. Among the most successful triumphs are the type-II superlattice photodetectors and quantum cascade lasers - these technologies have demonstrated the beauty of turning fundamental concepts into practical devices, thanks to advanced growth technologies. This enables us to design and realize compact devices capable of mimicking or even exceeding nature. Using superlattice to pioneer the development of quantum systems is driving the research work at the Center for Quantum Devices.

  12. Hereditarian scientific fallacies.

    PubMed

    Bailey, R C

    1997-01-01

    Some have recently declared that a hereditarian or more balanced approach has triumphed over environmentalism as an explanatory tool for variation in the cognitive ability and behaviour of humans. However, the entire debate is constrained by several fallacies described here. Heritability of a trait, does not predict the effect of environmental or genetic changes on the trait (Fallacy #1), so knowing heritability does not assist in writing prescriptions for societal ills or budget cuts. Heritability estimates themselves are inaccurate, given the potential for gene-environment covariance and interaction, as well as other non-additive effects on behavior or cognitive ability (Fallacy #2). The 'revolution in molecular genetics' has provided more effective tools for describing the genome, but doesn't permit separation of gene and environmental effects on traits (Fallacy #3). If we were able to measure heritability accurately, it would give us absolutely no indication of whether or not group differences are genetically based (Fallacy #4). Finally, any proposed models of the evolutionary divergence of human groups must more adequately answer the basic questions of such a study, and are not supported by high heritability in present populations (Fallacy #5). Humans are not and should never be exposed to artificial selection and crossing experiments, so behavior geneticists will continue to be very limited in their ability to partition the effects of genes, the environment, and their covariance and interaction on human behavior and cognitive ability. PMID:9463068

  13. Environmentalism unbound: reconnecting and re-envisioning movements for change.

    PubMed

    Gottlieb, R

    2001-01-01

    Disputes over environmental discourse have generated divergent pathways and discordant messages over the last three decades. An examination of them becomes a study of environmentalism s roots. The workplace is shown as a hidden and often discounted arena of debate about what constitutes an environmental issue. The triumph of the productionist and limitless consumption views helped to establish a focus on environmental change as a form of consumer action. Since the 1970s though, new forms of environmental discourse and action both community- and production-related have sought to shift the terrain. The possibility of becoming a broader, more socially inclusive movement capable of challenging the very structure and logic of capitalist social order is possible again, including the ability to identify new strategies for action. Overcoming the work/environment divide is perhaps the most contentious question facing the future of the environmental and labor movements. New approaches, including developing a community of interests, revaluing work, and developing an ethic of place (with urban, industrial, and global forms), require that the social and the ecological become joined in the construction of a common vision. When any environmental issue can be seen as socially determined, then environmentalism s great task will be to see itself as a primary agent of social change. PMID:17208705

  14. Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS).

    PubMed

    Simirgiotis, Mario J; Quispe, Cristina; Bórquez, Jorge; Areche, Carlos; Sepúlveda, Beatriz

    2016-01-01

    A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data (UHPLC-PDA-HESI-orbitrap-MS/MS). In addition, the antioxidant features of the fruits were compared with the varieties Packhman's Triumph and Abate Fetel and correlated with the presence of phenolic compounds. The non-pigmented phenolics were fingerprinted and related to the antioxidant capacities measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and total content of phenolics and flavonoids measured by spectroscopic methods. The machine allowed a fast separation of 15 min employing a flow rate of 1 mL per minute and could accurately identify 25 compounds, including several isorhamnetin derivatives and phenolic acids, present in the peel and pulps of this Chilean variety for the first time. The compounds were monitored using a wavelength range of 210-800 nm. The native small Chilean pear showed the highest antioxidant activity measured as the bleaching of the DPPH radical, the ferric reducing antioxidant power and superoxide anion scavenging activity (8.61 ± 0.65 μg/mL, 712.63 ± 12.12 micromols trolox equivalents (μmol/TE)/100 g FW, and 82.89% ± 2.52% at 100 μg/mL, respectively). PMID:26784158

  15. Engineering Manhattan style: Sandia Laboratories as an example of postwar engineering

    SciTech Connect

    1996-09-01

    A great deal has been written about the history of science in America since World War II. Much of that work has explored the government`s research and development establishment, focusing on the scientific community immediately after the war. It is generally argued that the apparent triumphs of the huge and expensive wartime research and development projects gave rise to a belief that scientific resources should be nurtured and kept on hand - ready to provide service in an emergency. The Cold War drive for more and better weapons further fed this belief, leading to a massive system of national laboratories, military laboratories, and defense industries. The science of this complex is built on extensive financial support, the central strategy of which is that by steadily, and occasionally even lavishly funding large research programs, you will have a constant stream of scientific ideas that can be applied to national security purposes. What is true of science, is also true, in slightly modified form, of postwar engineering. The story I want to tell you today is, I think, an example of the way Cold War engineering r&d for national security worked. This report describes aspects of the Sandia National Laboratories.

  16. After the fall: Political whitewashing, professional posturing, and personal refashioning in the postwar career of Otmar Freiherr von Verschuer.

    PubMed

    Weiss, Sheila Faith

    2010-12-01

    Despite the numerous books and articles preoccupied with the formidable legitimizing role and unethical medical transgressions of the German human geneticist Otmar von Verschuer (1896-1969) during the Third Reich, scholars have neglected to focus on his career trajectory during the postwar period, especially in the years after he received the first chair of genetics on German soil in 1951. While an examination of von Verschuer's trials, tribulations, and ultimate triumph in post-1945 West Germany is fascinating in its own right, it also raises broader historical issues. First, it lays bare the professional posturing of German biomedical scientists as they attempted to retake control over their once tainted fields of research when Cold War realities opened a window of opportunity for them. Second, it reveals the fine line between adherence to professional ethics and disciplinary solidarity when scientists were faced with a potential outside threat to their profession. Finally, such an analysis demonstrates the macromechanics of professional refashioning on the part of the publicly tainted scientists as they forged a new symbiosis between their field and the politics of a new era in the interest of pursuing research.

  17. Tobacco control policies and their impacts. Past, present, and future.

    PubMed

    Warner, Kenneth E

    2014-02-01

    The 1964 Surgeon General's report on smoking and health concluded that "Cigarette smoking is a health hazard of sufficient importance in the United States to warrant appropriate remedial action." The adoption of remedial actions over the next half century produced what is arguably the most important public health triumph of that period in the United States and in other developed nations. At the heart of the remedial actions were governmental policies. By raising cigarette price, taxation is especially effective at reducing smoking, encouraging some smokers to quit and others to reduce their daily consumption, while also discouraging the initiation of smoking by children. Smoke-free workplace policies have dramatically reduced workers' exposure to the toxins in cigarette smoke, smoking, employers' costs, and the incidence of acute myocardial infarctions. Other policies have also helped diminish the toll of smoking. The successes of tobacco control notwithstanding, future progress will occur slowly unless society finds new, possibly radical "endgame" strategies to hasten the arrival of a smoke-free society.

  18. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    NASA Astrophysics Data System (ADS)

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-05-01

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. Our results point at a large Fermi surface consistent with Luttinger’s theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition.

  19. Mate choice and sexual selection: What have we learned since Darwin?

    PubMed Central

    Jones, Adam G.; Ratterman, Nicholas L.

    2009-01-01

    Charles Darwin laid the foundation for all modern work on sexual selection in his seminal book The Descent of Man, and Selection in Relation to Sex. In this work, Darwin fleshed out the mechanism of sexual selection, a hypothesis that he had proposed in The Origin of Species. He went well beyond a simple description of the phenomenon by providing extensive evidence and considering the far-reaching implications of the idea. Here we consider the contributions of Darwin to sexual selection with a particular eye on how far we have progressed in the last 150 years. We focus on 2 key questions in sexual selection. First, why does mate choice evolve at all? And second, what factors determine the strength of mate choice (or intensity of sexual selection) in each sex? Darwin provided partial answers to these questions, and the progress that has been made on both of these topics since his time should be seen as one of the great triumphs of modern evolutionary biology. However, a review of the literature shows that key aspects of sexual selection are still plagued by confusion and disagreement. Many of these areas are complex and will require new theory and empirical data for complete resolution. Overall, Darwin's contributions are still surprisingly relevant to the modern study of sexual selection, so students of evolutionary biology would be well advised to revisit his works. Although we have made significant progress in some areas of sexual selection research, we still have much to accomplish. PMID:19528643

  20. Seven decades of history of science: I. Bernard Cohen (1914-2003), second editor of Isis.

    PubMed

    Dauben, Joseph W; Gleason, Mary Louise; Smith, George E

    2009-03-01

    I. Bernard Cohen (1914-2003), the first American to receive a Ph.D. in history of science, was a Harvard undergraduate ('37) and then a Ph.D. student and protégé of George Sarton, founder of Isis and the History of Science Society. He went on to succeed Sarton as editor of Isis (1952-1958) and, later, president of the Society (1961-1962); he was also a president of the International Union of the History and Philosophy of Science. Cohen was an internationally recognized Newton scholar; his interests were encyclopedic, ranging from science and public policy to the history of computers, with several decades as a special consultant for history of computing with IBM. Among his hundreds of publications were such major books as Franklin and Newton (1956), The Birth of a New Physics (1959; rpt., 1985), The Newtonian Revolution (1980), Revolution in Science (1985), Science and the Founding Fathers (1995), Howard Aiken: Portrait of a Computer Pioneer (1999), and his last book, The Triumph of Numbers (2005), not to mention two jointly authored contributions, the variorum edition and new English translation of Newton's Principia, which will surely still be read a century from now.

  1. Geometrical Standard Model Enhancements to the Standard Model of Particle Physics

    NASA Astrophysics Data System (ADS)

    Strickland, Ken; Duvernois, Michael

    2011-10-01

    The Standard Model (SM) is the triumph of our age. As experimentation at the LHC tracks particles for the Higgs phenomena, theoreticians and experimentalist struggle to close in on a cohesive theory. Both suffer greatly as expectation waivers those who seek to move beyond the SM and those who cannot do without. When it seems like there are no more good ideas enter Rate Change Graph Technology (RCGT). From the science of the rate change graph, a Geometrical Standard Model (GSM) is available for comprehensive modeling, giving rich new sources of data and pathways to those ultimate answers we punish ourselves to achieve. As a new addition to science, GSM is a tool that provides a structured discovery and analysis environment. By eliminating value and size, RCGT operates with the rules of RCGT mechanics creating solutions derived from geometry. The GSM rate change graph could be the ultimate validation of the Standard Model yet. In its own right, GSM is created from geometrical intersections and comes with RCGT mechanics, yet parallels the SM to offer critical enhancements. The Higgs Objects along with a host of new objects are introduced to the SM and their positions revealed in this proposed modification to the SM.

  2. (Mis)understanding Science: The Problem with Scientific Breakthroughs.

    PubMed

    Evans, James P

    2016-09-01

    On Saturday morning, February 28, 1953, the mystery of heredity appeared secure. Humans hadn't the faintest idea of how genetic information was transmitted-how the uncanny resemblance between mother and daughter, grandfather and grandson was conveyed across generations. Yet, by that Saturday afternoon, two individuals, James Watson and Francis Crick, had glimpsed the solution to these mysteries. The story of Watson and Crick's great triumph has been told and retold and has rightly entered the pantheon of scientific legend. But Watson and Crick's breakthrough was just that: a rupture and dramatic discontinuity in human knowledge that solved a deep mystery, the likes of which occurs, perhaps, a couple of times each century. And that's the problem. The story is just so good and so irresistible that it has misled generations of scientists about what to expect regarding a life in science. And more damaging, the resulting breakthrough mentality misleads the public, the media, and society's decision-makers about how science really works, all to the detriment of scientific progress and our society's well-being.

  3. 'Don't play the butter notes': jazz in medical education.

    PubMed

    Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

    2016-01-01

    Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years. PMID:27095009

  4. Elected Officials Travel in Parallel Universes Regarding the Affordable Care Act.

    PubMed

    Elwood, Thomas W

    2015-01-01

    While the ink still was drying on this issue of the Journal of Allied Health, the Patient Protection and Affordable Care Act (ACA) reached the ripe old age of 5-and-1/2 years. Simply mentioning this law to a great many members of Congress is the equivalent of administering a prick with a hot needle. Depending on whose opinions are sought, this significant piece of social legislation is considered either a monumental health policy triumph (according to a majority of Democrats) or a pitiful debacle (according to a majority of Republicans) in both chambers. Their respective points of view are aided and abetted by a small army of cheerleaders on the sidelines who inhabit pundit domains in foundations, think tanks, university policy centers, and radio/TV talk shows. Except in rare instances, neither side will admit that their opponents might be correct about some aspects of the law, because there really is not much pleasure derived from doing so. Despite their many enthusiastic proclamations regarding the ACA, it is not possible for both sides of the present controversy to be entirely correct. Hence, this essay represents an effort to describe various benefits associated with this key piece of legislation, along with some of its shortcomings. PMID:26342609

  5. After the fall: Political whitewashing, professional posturing, and personal refashioning in the postwar career of Otmar Freiherr von Verschuer.

    PubMed

    Weiss, Sheila Faith

    2010-12-01

    Despite the numerous books and articles preoccupied with the formidable legitimizing role and unethical medical transgressions of the German human geneticist Otmar von Verschuer (1896-1969) during the Third Reich, scholars have neglected to focus on his career trajectory during the postwar period, especially in the years after he received the first chair of genetics on German soil in 1951. While an examination of von Verschuer's trials, tribulations, and ultimate triumph in post-1945 West Germany is fascinating in its own right, it also raises broader historical issues. First, it lays bare the professional posturing of German biomedical scientists as they attempted to retake control over their once tainted fields of research when Cold War realities opened a window of opportunity for them. Second, it reveals the fine line between adherence to professional ethics and disciplinary solidarity when scientists were faced with a potential outside threat to their profession. Finally, such an analysis demonstrates the macromechanics of professional refashioning on the part of the publicly tainted scientists as they forged a new symbiosis between their field and the politics of a new era in the interest of pursuing research. PMID:21409983

  6. Disability and narrative: new directions for medicine and the medical humanities.

    PubMed

    Garden, Rebecca

    2010-12-01

    People with disabilities are a large minority that disproportionately seeks medical care. However, disability is relatively neglected in medical education and practice, and disabled people experience troubling differences and even disparities in healthcare. Practitioners can help improve healthcare for disabled people through disability studies, a multi-disciplinary field of enquiry that draws on the experiences and perspectives of people with disabilities to address discrimination. This article outlines a disability studies perspective on healthcare, specifically the rejection of the medicalisation of disability and difference in favour of an understanding of disability that focuses on social factors that disable, such as stigmatisation and a lack of accommodation. The 'social model' of disability can be expanded to chronic illness and to the broader work of the medial humanities. The author argues that narrative, particularly first-person accounts, provide a critical resource by representing the point of view of people with disabilities and by offering a means of examining the social context and social determinants of disability. The author examines specific conventions of narrative, the dominant plotlines such as the triumph over adversity, that predetermine experiences of disability and illness. Through disability studies and critical examinations of narrative informed by disability studies, practitioners can provide better care for patients with disabilities and work as allies towards more equitable relations in the clinic. PMID:21393285

  7. Fe-Al-Mn-C lightweight structural alloys: a review on the microstructures and mechanical properties

    NASA Astrophysics Data System (ADS)

    Kim, Hansoo; Suh, Dong-Woo; Kim, Nack J.

    2013-02-01

    Adding a large amount of light elements such as aluminum to steels is not a new concept recalling that several Fe-Al-Mn-C alloys were patented in 1950s for replacement of nickel or chromium in corrosion resistance steels. However, the so-called lightweight steels or low-density steels were revisited recently, which is driven by demands from the industry where steel has served as a major structural material. Strengthening without loss of ductility has been a triumph in steel research, but lowering the density of steel by mixing with light elements will be another prospect that may support the competitiveness against emerging alternatives such as magnesium alloys. In this paper, we review recent studies on lightweight steels, emphasizing the concept of alloy design for microstructures and mechanical properties. The influence of alloying elements on the phase constituents, mechanical properties and the change of density is critically reviewed. Deformation mechanisms of various lightweight steels are discussed as well. This paper provides a reason why the success of lightweight steels is strongly dependent on scientific achievements even though alloy development is closely related to industrial applications. Finally, we summarize some of the main directions for future investigations necessary for vitalizing this field of interest.

  8. Hereditarian scientific fallacies.

    PubMed

    Bailey, R C

    1997-01-01

    Some have recently declared that a hereditarian or more balanced approach has triumphed over environmentalism as an explanatory tool for variation in the cognitive ability and behaviour of humans. However, the entire debate is constrained by several fallacies described here. Heritability of a trait, does not predict the effect of environmental or genetic changes on the trait (Fallacy #1), so knowing heritability does not assist in writing prescriptions for societal ills or budget cuts. Heritability estimates themselves are inaccurate, given the potential for gene-environment covariance and interaction, as well as other non-additive effects on behavior or cognitive ability (Fallacy #2). The 'revolution in molecular genetics' has provided more effective tools for describing the genome, but doesn't permit separation of gene and environmental effects on traits (Fallacy #3). If we were able to measure heritability accurately, it would give us absolutely no indication of whether or not group differences are genetically based (Fallacy #4). Finally, any proposed models of the evolutionary divergence of human groups must more adequately answer the basic questions of such a study, and are not supported by high heritability in present populations (Fallacy #5). Humans are not and should never be exposed to artificial selection and crossing experiments, so behavior geneticists will continue to be very limited in their ability to partition the effects of genes, the environment, and their covariance and interaction on human behavior and cognitive ability.

  9. Environmentalism unbound: reconnecting and re-envisioning movements for change.

    PubMed

    Gottlieb, R

    2001-01-01

    Disputes over environmental discourse have generated divergent pathways and discordant messages over the last three decades. An examination of them becomes a study of environmentalism s roots. The workplace is shown as a hidden and often discounted arena of debate about what constitutes an environmental issue. The triumph of the productionist and limitless consumption views helped to establish a focus on environmental change as a form of consumer action. Since the 1970s though, new forms of environmental discourse and action both community- and production-related have sought to shift the terrain. The possibility of becoming a broader, more socially inclusive movement capable of challenging the very structure and logic of capitalist social order is possible again, including the ability to identify new strategies for action. Overcoming the work/environment divide is perhaps the most contentious question facing the future of the environmental and labor movements. New approaches, including developing a community of interests, revaluing work, and developing an ethic of place (with urban, industrial, and global forms), require that the social and the ecological become joined in the construction of a common vision. When any environmental issue can be seen as socially determined, then environmentalism s great task will be to see itself as a primary agent of social change.

  10. Chronic myeloid leukemia: reminiscences and dreams.

    PubMed

    Mughal, Tariq I; Radich, Jerald P; Deininger, Michael W; Apperley, Jane F; Hughes, Timothy P; Harrison, Christine J; Gambacorti-Passerini, Carlo; Saglio, Giuseppe; Cortes, Jorge; Daley, George Q

    2016-05-01

    With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people's lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman. PMID:27132280

  11. [Analytical chemistry in works of Maria Skłodowska-Curie].

    PubMed

    Hulanicki, Adam

    2012-01-01

    Maria Skłodowska-Curie--a Nobel Prize winner in chemistry--the elements of learning of chemistry gained just by a dint of work of more than ten months in Warsaw in the Institute of Industry and Agriculture Museum. The Nobel Prize concerned a contribution to the progress of chemistry through the discovery of radium and polonium, separation of radium and study of properties of this amazing element. It was awarded for an extremely arduous work, during which the chemical reactions being the principles of analytical chemistry were realized. Unlike to a typical analytical procedure, an initial attempt here was the thousands of kilograms of uranium ore: pitchblende. The final effect was small amounts of new elements: polonium and radium. Both the knowledge and the intuition of the researcher let her have a triumph. The difficulties she experienced because the properties of the searched chemical elements could only be evaluated thanks to the knowledge on other chemical elements. A significant achievement was the determination of the samples by means of radioactivity measurement, which gave rise to radiochemical analytical methods. An extreme analytical precision was demanded in multiple processes of fractional crystallization and precipitation which finally led to the calculation of the atomic mass of radium.

  12. The Life and Times of John Couch Adams, from 1819 to 1847

    NASA Astrophysics Data System (ADS)

    Sheen, Brian M.

    2011-01-01

    John Couch Adams was born in 1819 in the middle of Cornwall, the most remote and isolated county in England. How he progressed from there to Cambridge University to become one of the finest mathematicians of the nineteenth century fills everyone who studies him with awe. Tragically what should have been his greatest triumph - the discovery of a new planet - was marred by mishap, controversy and unanswered questions. This presentation examines one of the first of these questions and provides new answers based on recently revealed evidence. The Astronomer Royal of the day was attempting to support Adams and as part of that support asked if his analysis took into account changes in radius vector of Uranus. Adams did not reply and the rest as they say is history. However there is far more to the question than a non-existent letter - this in itself turns out to be not exactly true. Further analysis of the orbits and a letter in French - not been translated before reveals Adams had a more profound understanding of the situation than some later authors have given him credit.

  13. The return of the natural philosopher

    NASA Astrophysics Data System (ADS)

    Lehner, Ed

    2010-03-01

    John R. Staver's article calling for a constructivist epistemology to maneuver between the disparate ways of knowing between science and religion prompts this response. This paper acknowledges Staver's scholarly analysis of the issue. Scientific and religious conflicts do present prominent challenges because these are profound but often-monolithic ways of constructing knowledge. However, my response withholds fully embracing Staver's call for a constructivist epistemology chiefly because his work goes beyond the confines of constructivism. Conversely, Staver's call for constructivist epistemology does not go far enough to advance a resolution between science and religion. Why? Because both science and religion often employ hyper-rationality in understanding the world, a process that does little to clarify the world's complexities. Philosophically, I refrain from accepting a complete schism between the two because such a framing does little to heal a conflict between those who praise the seen and those who praise the unseen. My response explores how hyper-rationality has triumphed over both science and religion, leaving the believer in one, or both, to navigate the journey alone. This article calls for the return of the natural philosopher. Utilizing this nineteenth-century term for scientist, this paper calls for an inquirer, one who can rise above the ideologies of science and religion to observe the current concerns of each field anew. Finally, taking a cue from Staver, this response introduces a potential discourse between science and religion in ways that each may, without embracing a variant ideology, make space for dialogue and mutual respect.

  14. In accordance with a "more majestic order". The new math and the nature of mathematics at midcentury.

    PubMed

    Phillips, Christopher J

    2014-09-01

    The "new math" curriculum, one version of which was developed in the 1950s and 1960s by the School Mathematics Study Group under the auspices of the National Science Foundation, occasioned a great deal of controversy among mathematicians. Well before its rejection by parents and teachers, some mathematicians were vocal critics, decrying the new curriculum because of the way it described the practice and history of the discipline. The nature of mathematics, despite the field's triumphs in helping to win World War II and its midcentury promotion as the key to a modern technological society, was surprisingly contested in this period. Supporters of the School Mathematics Study Group, like its director, Edward Begle, emphasized the importance of portraying mathematics as a system of abstract structures, while opponents like Morris Kline argued that math was essentially a tool for understanding the natural world. The debate about the curriculum--and the role of mathematicians in its design--was also a debate about the underlying identity of the subject itself.

  15. Making mobility-related disability better: a complex response to a complex problem.

    PubMed

    Rockwood, Kenneth

    2012-01-01

    Mobility disability in older adults can arise from single system problems, such as discrete musculoskeletal injury. In frail older adults, however, mobility disability is part of a complex web of problems. The approach to their rehabilitation must take that complexity into account, as is reported by Fairhall et al. First, their overall health state must be assessed, which is achieved by a comprehensive geriatric assessment. The assessment can show how a particular patient came to be disabled, so that an individualized care plan can be worked out. Whether this approach works in general can be evaluated by looking at group differences in mean mobility test scores. Knowing whether it has worked in the individual patient requires an individualized measure. This is because not every patient starts from the same point, and not every patient achieves success by aiming for the same goal. For one patient, walking unassisted for three metres would be a triumph; for another it would be a tragedy. Unless we understand the complexity of the needs of frail older adults, we will neither be able to treat them effectively nor evaluate our efforts sensibly.Please see related article http://www.biomedcentral.com/1741-7015/10/120.

  16. 'Don't play the butter notes': jazz in medical education.

    PubMed

    Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

    2016-01-01

    Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years.

  17. Foundations of Chemistry: Special Issue on the Periodic System (editor-in-chief Eric R. Scerri)

    NASA Astrophysics Data System (ADS)

    Bernal, Pedro J.

    2002-12-01

    Here the issues are of great practical importance. I’ll separate them into two areas. First, just a superficial exposure to foundational issues renders the naive view of the scientific method untenable. The initial article in this issue, by Giunta, clearly shows scientists engaged in coming up with the “best account” of the evidence available to them. They were, of course, trying to make argon “fit” into the periodic system and therefore inevitably reading the evidence within a series of presuppositions determined by their conception of the periodic system. The point is that one does not get a sense of the application of a “method” of any kind. This is always the lesson of the history of science. Second, there is no question that textbooks, what we teach, and the way we teach it are influenced by philosophical presuppositions. All general chemistry textbooks are heavily influenced by reductionist assumptions. A quantum mechanical model of the atom from which everything follows precedes the variation of atomic properties and the chemistry of the elements. I have to say here that the triumph of this model, in my view, results not only from its explanatory power (the fact that it is not as great as it is claimed is one of the central claims this journal tries to make), but because reduction entails simplification and simplification is always pedagogically attractive. I, for one, think that the reductive enterprise is untenable but I recognize the immense pedagogical advantage of the current model. The following question seems to me an important one: must science pedagogy be necessarily reductive? The answer may be yes even if reduction is impossible. These are important issues and thanks to journals such as Foundations we know that the conversation will continue.

  18. How citation boosts promote scientific paradigm shifts and nobel prizes.

    PubMed

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-01-01

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the "boosting effect" of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying "boost factor" is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract. PMID:21573229

  19. Calculating Total Electron Content under the presence of the Aurora Borealis in Fairbanks, Alaska, and Kiruna, Sweden.

    NASA Astrophysics Data System (ADS)

    Ahmad, H.; Ehteshami, A.; Edgar, B.

    2015-12-01

    With the presence of the ionosphere and plasmasphere interacting with geomagnetic storms, scattering effects can be seen by the signals sent to and by GPS/GLONASS satellites. To quantify this dispersive effect, scientists look into what the culprit is that causes this signal bias on an atomic level. Results have shown that the concentration of oscillating electrons is directly proportional to the amount of bias the signal from a point on earth to a GPS satellite witnesses. This is called the Total Electron Content (TEC) of a specified path, measured in electrons per meters squared (. In this project, the process of collecting and analyzing TEC units was kept the same as the previous methods while keeping the cost below $3,000. Using a dual-frequency GNSS receiver from Javad, Triumph-2, the project team recorded a series of 24 hour interval data logs as the receiver stored incoming signals from any reachable satellite. Because of the dispersive media in the ionosphere, the signal witnesses a bend in its path causing a delay, called the Slant TEC (sTEC). Using libraries from GPStk and TEQC, we analyzed RINEX files to view the differential phase and differential pseudorange frequency to compute slant TEC units (sTECU). Using the obtained data, we analyzed the difference between the sTEC units collected in Houston, Texas to the ones collected in Fairbanks, Alaska. Afterwards, the project will continue on another balloon in Kiruna, Sweden at the Esrange Space Center. The receiver will be in flight this time on a 48 hour flight.

  20. A brief history of hepatitis milestones.

    PubMed

    Trepo, Christian

    2014-02-01

    Hepatitis has been a major plague of mankind. The history of the discovery of causative viruses is one of the most fascinating scientific adventures of this half century. Individualization of several types of hepatitis only emerged after world war two. Their identification has been associated with milestones which revolutionized medicine and public health. The discovery of HBV brought the first ever vaccine not prepared by tissue culture but initially directly from plasma and soon the first vaccine produced by genetic engineering. HBV vaccine proved to be the first "anti-cancer" vaccine by preventing hepatocellular carcinoma and practically eradicating it from childhood in Taiwan. Successful vaccines became also available for HAV and more recently HEV. The discovery of HCV in 1989 opened a new era since it was the first virus was identified by a direct molecular approach. Two billion people are infected with HBV and 350 million are chronic carriers of the virus. The extraordinary effectiveness of HBV vaccination was best illustrated in Taiwan and Singapore where in less than 2 decades HBs Ag carriers dropped from 9,1% to 2,7% and HCC from 27% to 17%. Successful development of nucleos(t)ides analogs make it now possible to fully control disease progression with a daily pill long term therapy. The progress in HCV therapy has been even more spectacular and successful treatment jumped from 6 % with interferon alone in 1986 to more than 80% in 2013 with triple combination therapies. Remarkably chronic hepatitis C is the only chronic disease which is curable. It will be soon possible to eradicate HCV infection with, an all oral, daily single pill (containing several molecules) for 3 to 6 months which will cure over 90% of patients. This unprecedented therapeutic victory benefiting hundred millions of people matches the triumphs over small pox, polio and tuberculosis. The next 10 years should undoubtedly witness cure or full control over all forms of acute and chronic

  1. Escherichia coli and the French School of Molecular Biology.

    PubMed

    Ullmann, Agnes

    2010-09-01

    André Lwoff, Jacques Monod, and François Jacob, the leaders of the French school of molecular biology, greatly contributed between 1937 and 1965 to its development and triumph. The main discovery of Lwoff was the elucidation of the mechanism of bacteriophage induction, the phenomenon of lysogeny, that led to the model of genetic regulation uncovered later by Jacob and Monod. Working on bacterial growth, Monod discovered in 1941 the phenomenon of diauxy and uncovered the nature of enzyme induction. By combining genetic and biochemical approaches, Monod brought to light the structure and functions of the Escherichia coli lactose system, comprising the genes necessary for lactose metabolism, i.e., β-galactosidase and lactose permease, a pump responsible for accumulation of galactosides into the cells. An additional genetic factor (the i gene) determines the inducibility and constitutivity of enzyme synthesis. Around the same time, François Jacob and Elie Wollman dissected the main events of bacterial conjugation that enabled them to construct a map of the E. coli chromosome and to demonstrate its circularity. The genetic analysis of the lactose system led Monod and Jacob to elucidate the mechanism of the regulation of gene expression and to propose the operon model: a unit of coordinate transcription. One of the new concepts that emerged from the operon model was messenger RNA. In 1963, Monod developed one of the most elegant concepts of molecular biology, the theory of allostery. In 1965, Lwoff, Monod and Jacob were awarded the Nobel Prize in Physiology or Medicine. PMID:26443784

  2. Looking for earths : the race to find new solar systems

    NASA Astrophysics Data System (ADS)

    Boss, Alan

    1998-09-01

    The ultimate insider's account of astronomy's fantastic voyage in search of brave new worlds in faraway galaxies "Highly recommended." -Science and Technology "Full of humor, heartbreak, and a deep understanding of the ardor and luck that compose years of research. . . . The reader becomes not merely a receiver of Boss's vision, but a fellow explorer." -Astronomy "A rewarding account." -Scientific American Are we alone in the universe . . . or are there other planets generating and sustaining life? The question may be as old as civilization, but in the twilight of a century marked by countless frustrated quests to find other solar systems, several teams of pioneering astronomers have at last discovered a rich crop of mammoth, Jupiter-sized gas planets -the first compelling evidence that there may indeed be life in other galaxies. In Looking for Earths, a prominent planetary scientist takes us along on this thrilling hunt for new life, revealing the behind-the-scenes stories of scientific determination, frustration, and triumph. Ushering us to the mountaintop observatories that house the world's most powerful telescopes, and into the tension-filled scientific meetings where new results are announced and old results overturned, Alan Boss brings the process of exploration vividly alive. Experience the roller-coaster ride as intricate observations of minuscule stellar wobbles raise hopes that at last a true planet has been found, only to be almost immediately shattered by more powerful observations. Boss also introduces the principal players whose dreams defied all odds and made the first major discovery possible. Like no other book, Looking for Earths captures the lively tension between theory and observation that defines cutting-edge astronomical discovery, along with the heated battles that will determine the direction of big-ticket American astronomy for years to come. "You will find no better introduction to one of the truly revolutionary developments in modern

  3. The drum is the shaman, the spear guides his voice.

    PubMed

    Hoskins, J

    1988-01-01

    Kodi rituals of curing use anthropomorphized objects--the drum and the spear--as intermediaries to communicate with the spirits causing the affliction. The spear 'cuts through' to the cause of the illness at the divination, by guiding the arm and voice of the human diviner. The drum beaten during an all night ceremony has a more important role: a myth at the opening of the ceremony tells the drum's personal story or biography, which is identified with the suffering patient. In the course of the ceremony it travels on a shamanistic journey to the upperworld to seek the blessings of health and well-being. The myth of the drum's origin provides a narrative structure for the whole ritual, and defines the basis for its efficacy. The percussive sounds of the drum and gongs are said to make the patient feel better. A case study shows how 'ordered sound' is used to dissolve social tensions into a culturally structured pattern, so that consensus can be achieved in implicit accommodations in which neither party loses face. An older man's illness awakens guilty feelings among his younger relatives, whose thieving is believed to be responsible. The healing ritual creates the context for them to express contrition without confessing. Thus, although the rite re-establishes communication between persons and between the human and spirit worlds, it involves deception and silences as well as revelations. Through an analytic comment on social tensions, artistic illusions are used to overcome the airing of social differences. The healing rite is intended to restore a social consensus, produced by a combination of music, speech and actions, which allow signs to triumph over substance.

  4. [From relativism to evaluation. Recent trends in the historiography of science and the humanities].

    PubMed

    Jonker, Ed

    2011-01-01

    Historians of science have taken leave of finalism. No longer do they write teleological histories of scientific progress. Instead of a grand narrative on the triumph of science they now tend to write small stories on local knowledge. This is the result of several decades of criticism of Whig history. Starting with neo-marxist critique in the interwar years, enhanced in the social history of the 1970s, science was seen as an economic commodity and as a social product. Cultural history and anthropology added the view that scientists and scholars are mere mortals, muddling through messy life. This critique was topped off with postmodern criticism of knowledge as power, which translates into the accusation that historiography is only legitimating cultural and political oppression. To counter these allegations, many historians have insulated themselves into a kind of retro-historicism that shies away from any teleology, coherence, meaning and evaluation. It depicts the production of knowledge as a practical, local activity that is strictly limited to its cultural context. No claims to truth, validity, let alone progress or even development were allowed. This situation of rampant relativism could not last. Total abstinence of any evaluation of knowledge claims, quality of research or success of theories has proven unsatisfactory. The need has arisen to study broader issues of traveling knowledge and longer lines of scientific development. There is a shift of interest into traditions of knowledge that spring the bonds of locality and context. Why do some scientific theories and research practices succeed in surpassing paradigms and bridging epistemic ruptures? In this respect disciplines are in the process of being rehabilitated. Instead of oppressive structures they become the vehicles of sustained knowledge growth. Especially the role of education and academic training is focused on. Facing up to the charges of conceptual anachronism, historians of knowledge now opt

  5. How Citation Boosts Promote Scientific Paradigm Shifts and Nobel Prizes

    PubMed Central

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-01-01

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the “boosting effect” of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying “boost factor” is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract. PMID:21573229

  6. The role of psychopharmacology in the medical abuses of the Third Reich: from euthanasia programmes to human experimentation.

    PubMed

    López-Muñoz, Francisco; Alamo, Cecilio; García-García, Pilar; Molina, Juan D; Rubio, Gabriel

    2008-12-16

    German psychiatry and pharmacology both enjoyed an extraordinary international reputation prior to the promulgation of the Third Reich. However, with the triumph of eugenic ideas and the imposition of a "racial hygiene" policy by the Nazi regime, various organs of the German health system saw themselves involved in a perverse system of social control, in which the illicit use of psychopharmacological tools became customary. In the present work, we review, from the historical perspective, the factors that helped to bring about this situation and we analyze the abuses (known and documented) committed through the specific use of psychotropic drugs during the Nazi period. Among such abuses we can identify the following illegitimate activities: the use of psychoactive drugs, mainly sedatives from the barbiturates family, in the different euthanasia programmes implemented by the Nazi authorities, in police activity and various types of repression, and for purely criminal and extermination purposes within the so-called "Final Solution"; psychopharmacological research on the mentally ill, without the slightest ethical requirements or legal justification; and the use of psychotropic agents in research on healthy subjects, recruited from concentration camps. Finally, we refer to the role of poisonous nerve agents (tabun, sarin and soman) as instruments of chemical warfare and their development by the German authorities. Many of these activities, though possibly only a small portion of the total - given the destruction of a great deal of documentation just before the end of World War II - came to light through the famous Nuremberg Trials, as well as through other trials in which specific persons were brought to justice unilaterally by individual Allied nations or by the authorities of the new German government after the War. PMID:18848972

  7. How citation boosts promote scientific paradigm shifts and nobel prizes.

    PubMed

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-05-04

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the "boosting effect" of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying "boost factor" is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract.

  8. Single Stage to Orbit: Politics, Space Technology, and the Quest for Reusable Rocketry

    NASA Technical Reports Server (NTRS)

    Butrica, Andrew J.

    2003-01-01

    While the glories and tragedies of the space shuttle make headlines and move the nation, the story of the shuttle forms an inseparable part of a lesser-known but no less important drama-the search for a re-useable single-stage-to-orbit rocket. Here an award-winning student of space science, Andrew J. Butrica, examines the long and tangled history of this ambitious concept, from it first glimmerings in the 1920s, when technicians dismissed it as unfeasible, to its highly expensive heyday in the midst of the Cold War, when conservative-backed government programs struggled to produce an operational flight vehicle. Butrica finds a blending of far-sighted engineering and heavy-handed politics. To the first and oldest idea-that of the reusable rocket-powered single-stage- to-orbit vehicle-planners who belonged to what President Eisenhower referred to as the military-industrial complex added experimental (" X "), "aircraft-like" capabilities and, eventually, a "faster, cheaper, smaller" managerial approach. Single Stage to Orbit traces the interplay of technology, corporate interest, and politics, a combination that well served the conservative space agenda and ultimately triumphed-not in the realization of inexpensive, reliable space transport-but in a vision of space militarization and commercialization that would appear settled United States policy in the early twenty-first century. "The 'holy grail' of the spaceship movement has been the development of a vehicle that could accomplish single stage to orbit (SSTO) flight. This study describes the evolution of this concept from the 192'0s to the present, revealing a conservative space agenda that has not yet been the subject of historical analysis. As such, it makes an important contribution to space history literature."-Roger D. Launius, The Smithsonian Institution.

  9. Bioextraction of soil boron by tall fescue.

    PubMed

    Bañuelos, G S; Mackey, B; Wu, L; Zambrzuski, S; Akohoue, S

    1995-07-01

    High concentrations of soil B are detrimental to crop productivity in certain arid and semiarid regions of the western United States. Production of tall fescue on B-affected soils may be a viable strategy to reduce and maintain soil B concentrations at nontoxic levels for most agronomic crops. A 2-year field experiment was conducted to study B uptake in tall fescue (Festuca arundinacea) Schreb. cv. Au Triumph grown in soil containing potentially toxic levels of native soil B. The soil B concentrations (water-extractable B greater than 5 mg B liter-1) did not affect the dry matter (DM) yield of tall fescue. Boron concentrations in shoot tissue for both years ranged from 88 to 121 mg B kg-1 DM. whereas in root tissue, concentrations ranged from 50 to 60 mg B kg-1 DM. For both years of the study, soil samples were taken at depth of 0-45 and 45-90 cm at the beginning and end of the designated growing season and analyzed for water-extractable B. Summary data from all cropped plots at the two soil depths indicated that the mean water-extractable B concentrations were reduced by 35% after 2 years in the tall fescue plots, whereas losses of extractable B from bare plots did not exceed 13% for both years. Tall fescue apparently can be used as a component in an overall strategy to lower extractable soil native B levels in irrigated agriculture soils and potentially reduce leaching of B into shallow ground water. PMID:8521775

  10. Toward a Rethinking of the Relativity Revolution

    NASA Astrophysics Data System (ADS)

    Siegel, Daniel

    2014-03-01

    This journey in the history of physics is offered in celebration of David Cassidy's Pais Prize. The journey, undertaken in part with the community of historians of physics and in part not, starts from a conventional characterization of the relativity revolution as an abrupt transition, in 1905, from pre-Einsteinian darkness to Einsteinian light, and ends with an alternative perspective on the relativity revolution, seeing it as a process extending over 50 years, in two phases: first, the protorelativity phase, lasting from the early 1880s to 1905, and involving initial treatments of the length contraction, the mass increase, and invariance properties; second, the Einsteinian phase, beginning with his recasting of the basic theoretical framework--with the inclusion now of the time dilation and the E = mc2 relationship--and continuing with the ensuing competition between the protorelativistic and Einsteinian approaches, issuing in the final triumph of the Einsteinian approach only in the early 1930s. A proper appreciation of the character and importance of the protorelativity phase of the relativity revolution is relevant to a variety of contexts: for the teaching of relativity theory, it makes available a more concrete and pictorial approach to the relativistic effects--retaining greater (length contraction) or somewhat lesser (mass increase) validity to the present day; for the ongoing discourse on the nature of scientific revolutions, it provides a perspective on the intricacies and complexities of those occurrences, and on the elements of continuity and gradualism in even the most radical changes; and for our general understanding of historical process in the history of the sciences, it shows the importance of the broader scientific research community for even the most individual accomplishments.

  11. MicroPET/CT Imaging of an Orthotopic Model of Human Glioblastoma Multiforme and Evaluation of Pulsed Low-Dose Irradiation

    SciTech Connect

    Park, Sean S.; Chunta, John L.; Robertson, John M.; Martinez, Alvaro A.; Oliver Wong, Ching-Yee; Amin, Mitual; Wilson, George D.; Marples, Brian

    2011-07-01

    Purpose: Glioblastoma multiforme (GBM) is an aggressive tumor that typically causes death due to local progression. To assess a novel low-dose radiotherapy regimen for treating GBM, we developed an orthotopic murine model of human GBM and evaluated in vivo treatment efficacy using micro-positron-emission tomography/computed tomography (microPET/CT) tumor imaging. Methods: Orthotopic GBM xenografts were established in nude mice and treated with standard 2-Gy fractionation or 10 0.2-Gy pulses with 3-min interpulse intervals, for 7 consecutive days, for a total dose of 14 Gy. Tumor growth was quantified weekly using the Flex Triumph (GE Healthcare/Gamma Medica-Ideas, Waukesha, WI) combined PET-single-photon emission CT (SPECT)-CT imaging system and necropsy histopathology. Normal tissue damage was assessed by counting dead neural cells in tissue sections from irradiated fields. Results: Tumor engraftment efficiency for U87MG cells was 86%. Implanting 0.5 x 10{sup 6} cells produced a 50- to 70-mm{sup 3} tumor in 10 to 14 days. A significant correlation was seen between CT-derived tumor volume and histopathology-measured volume (p = 0.018). The low-dose 0.2-Gy pulsed regimen produced a significantly longer tumor growth delay than standard 2-Gy fractionation (p = 0.045). Less normal neuronal cell death was observed after the pulsed delivery method (p = 0.004). Conclusion: This study successfully demonstrated the feasibility of in vivo brain tumor imaging and longitudinal assessment of tumor growth and treatment response with microPET/CT. Pulsed radiation treatment was more efficacious than the standard fractionated treatment and was associated with less normal tissue damage.

  12. Masters of Healing: Cocaine and the Ideal of the Victorian Medical Man

    PubMed Central

    Small, Douglas

    2016-01-01

    This article offers a new perspective on the relationship between cocaine and medical practitioners in late nineteenth- and early twentieth-century Britain. Cocaine is often understood as one of a number of potentially addictive substances to which Victorian physicians and surgeons were regularly exposed, and tempted to indulge in. However, while cocaine has frequently been associated with discourses of addiction, this article proposes that it was also widely represented as a technological triumph, and that the drug was frequently used as a symbol for the scientific and moral virtues of the medical man. The argument draws on popular journalism, medical publications, and fiction to establish the cultural context of cocaine at the fin de siècle. In 1884, cocaine was revealed to be the first effective local anaesthetic, and this article traces the processes by which cocaine came to be regarded as the iconic achievement of nineteenth-century therapeutic science. This aura of innovative brilliance in turn communicated itself to the medical professionals who employed cocaine in their work, so that many patients and practitioners alike depicted cocaine as a most fitting emblem for the idealized selfhood of the modern medical man. This idea also informs portrayals of the drug in fiction, and I conclude with a detailed analysis of L. T. Meade’s 1895 short story, ‘The Red Bracelet’ (published in the Strand Magazine as part of Meade’s series, ‘Stories from the Diary of a Doctor’), as an example of the way in which cocaine functions as metaphor for the physician’s unassailable moral primacy and technical excellence. PMID:27110213

  13. Escherichia coli and the French School of Molecular Biology.

    PubMed

    Ullmann, Agnes

    2010-09-01

    André Lwoff, Jacques Monod, and François Jacob, the leaders of the French school of molecular biology, greatly contributed between 1937 and 1965 to its development and triumph. The main discovery of Lwoff was the elucidation of the mechanism of bacteriophage induction, the phenomenon of lysogeny, that led to the model of genetic regulation uncovered later by Jacob and Monod. Working on bacterial growth, Monod discovered in 1941 the phenomenon of diauxy and uncovered the nature of enzyme induction. By combining genetic and biochemical approaches, Monod brought to light the structure and functions of the Escherichia coli lactose system, comprising the genes necessary for lactose metabolism, i.e., β-galactosidase and lactose permease, a pump responsible for accumulation of galactosides into the cells. An additional genetic factor (the i gene) determines the inducibility and constitutivity of enzyme synthesis. Around the same time, François Jacob and Elie Wollman dissected the main events of bacterial conjugation that enabled them to construct a map of the E. coli chromosome and to demonstrate its circularity. The genetic analysis of the lactose system led Monod and Jacob to elucidate the mechanism of the regulation of gene expression and to propose the operon model: a unit of coordinate transcription. One of the new concepts that emerged from the operon model was messenger RNA. In 1963, Monod developed one of the most elegant concepts of molecular biology, the theory of allostery. In 1965, Lwoff, Monod and Jacob were awarded the Nobel Prize in Physiology or Medicine.

  14. The CEO's second act.

    PubMed

    Nadler, David A

    2007-01-01

    When a CEO leaves because of performance problems, the company typically recruits someone thought to be better equipped to fix what the departing executive couldn't--or wouldn't. The board places its confidence in the new person because of the present dilemma's similarity to some previous challenge that he or she dealt with successfully. But familiar problems are inevitably succeeded by less familiar ones, for which the specially selected CEO is not quite so qualified. More often than not, the experiences, skills, and temperament that yielded triumph in Act I turn out to be unequal to Act II's difficulties. In fact, the approaches that worked so brilliantly in Act I may be the very opposite of what is needed in Act II. The CEO has four choices: refuse to change, in which case he or she will be replaced; realize that the next act requires new skills and learn them; downsize or circumscribe his or her role to compensate for deficiencies; or line up a successor who is qualified to fill a role to which the incumbent's skills and interests are no longer suited. Hewlett-Packard's Carly Fiorina exemplifies the first alternative; Merrill Lynch's Stanley O'Neal the second; Google's Sergey Brin and Larry Page the third; and Quest Diagnostics' Ken Freeman the fourth. All but the first option are reasonable responses to the challenges presented in the second acts of most CEOs' tenures. And all but the first require a power of observation, a propensity for introspection, and a strain of humility that are rare in the ranks of the very people who need those qualities most. There are four essential steps executives can take to discern that they have entered new territory and to respond accordingly: recognition that their leadership style and approach are no longer working; acceptance of others' advice on why performance is faltering; analysis and understanding of the nature of the Act II shift; and, finally, decision and action.

  15. Modeling and Reality in Early Twentieth-Century Physics

    NASA Astrophysics Data System (ADS)

    Seth, Suman

    2011-04-01

    Towards the end of 1913, Arnold Sommerfeld, Professor of theoretical physics at Munich University, sent a letter of congratulations to a young Niels Bohr. The Dane's now-classic trilogy of papers, which coupled Rutherford's conception of the atom with a ``planetary'' configuration of electrons, had just appeared. Sommerfeld saw the calculation of the Rydberg constant as a singular triumph and immediately spotted an opportunity to try to explain the Zeeman effect. Yet he also sounded a note of caution, confessing that he remained ``somewhat skeptical'' of atomic models in general. In this, of course, he was hardly alone. Bohr's atom was a particularly egregious example of a peculiar model, one requiring what even its creator considered ``horrid assumptions.'' Nonetheless, success bred conviction. Expanding upon Bohr's original ideas, Sommerfeld soon produced the so-called ``Bohr-Sommerfeld quantization conditions,'' using them to calculate a myriad of results. Experimental evidence, Sommerfeld argued in 1915, showed that quantised electron-paths ``correspond exactly to reality'' and possess ``real existence.'' This kind of realism would not, of course, last long. In 1925, Werner Heisenberg (earlier a student of Sommerfeld's) made scepticism about the details of the Bohr model into a methodological dictum, one later enshrined in the ``Copenhagen interpretation'' of quantum mechanics. This paper uses Sommerfeld's work from the turn of the twentieth century to the mid-1920s as a window onto a landscape involving multiple contestations over the legitimacy of atomic modelling. The surprise that greeted Heisenberg's and others' phenomenological insistences, we will see, can only be understood with reference to what should be considered a ``realist interlude'' in the history of twentieth century atomic physics, one inspired by the astonishing successes of Rutherford's and Bohr's imaginings.

  16. John Bahcall and the Solar Neutrino Problem

    NASA Astrophysics Data System (ADS)

    Bahcall, Neta

    2016-03-01

    ``I feel like dancing'', cheered John Bahcall upon hearing the exciting news from the SNO experiment in 2001. The results confirmed, with remarkable accuracy, John's 40-year effort to predict the rate of neutrinos from the Sun based on sophisticated Solar models. What began in 1962 by John Bahcall and Ray Davis as a pioneering project to test and confirm how the Sun shines, quickly turned into a four-decade-long mystery of the `Solar Neutrino Problem': John's models predicted a higher rate of neutrinos than detected by Davis and follow-up experiments. Was the theory of the Sun wrong? Were John's calculations in error? Were the neutrino experiments wrong? John worked tirelessly to understand the physics behind the Solar Neutrino Problem; he led the efforts to greatly increase the accurately of the solar model, to understand its seismology and neutrino fluxes, to use the neutrino fluxes as a test for new physics, and to advocate for important new experiments. It slowly became clear that none of the then discussed possibilities --- error in the Solar model or neutrino experiments --- was the culprit. The SNO results revealed that John's calculations, and hence the theory of the Solar model, have been correct all along. Comparison of the data with John's theory demanded new physics --- neutrino oscillations. The Solar Neutrino saga is one of the most amazing scientific stories of the century: exploring a simple question of `How the Sun Shines?' led to the discovery of new physics. John's theoretical calculations are an integral part of this journey; they provide the foundation for the Solar Neutrino Problem, for confirming how the Sun shines, and for the need of neutrino oscillations. His tenacious persistence, dedication, enthusiasm and love for the project, and his leadership and advocacy of neutrino physics over many decades are a remarkable story of scientific triumph. I know John is smiling today.

  17. Firing back: how great leaders rebound after career disasters.

    PubMed

    Sonnenfeld, Jeffrey A; Ward, Andrew J

    2007-01-01

    Among the tests of a leader, few are more challenging-and more painful-than recovering from a career catastrophe. Most fallen leaders, in fact, don't recover. Still, two decades of consulting experience, scholarly research, and their own personal experiences have convinced the authors that leaders can triumph over tragedy--if they do so deliberately. Great business leaders have much in common with the great heroes of universal myth, and they can learn to overcome profound setbacks by thinking in heroic terms. First, they must decide whether or not to fight back. Either way, they must recruit others into their battle. They must then take steps to recover their heroic status, in the process proving, both to others and to themselves, that they have the mettle necessary to recover their heroic mission. Bernie Marcus exemplifies this process. Devastated after Sandy Sigoloff ired him from Handy Dan, Marcus decided to forgo the distraction of litigation and instead make the marketplace his batttleground. Drawing from his network of carefully nurtured relationships with both close and more distant acquaintances, Marcus was able to get funding for a new venture. He proved that he had the mettle, and recovered his heroic status, by building Home Depot, whose entrepreneurial spirit embodied his heroic mission. As Bank One's Jamie Dimon, J.Crew's Mickey Drexler, and even Jimmy Carter, Martha Stewart, and Michael Milken have shown, stunning comebacks are possible in all industries and walks of life. Whatever the cause of your predicament, it makes sense to get your story out. The alternative is likely to be long-lasting unemployment. If the facts of your dismissal cannot be made public because they are damning, then show authentic remorse. The public is often enormously forgiving when it sees genuine contrition and atonement.

  18. Biodegradation of atrazine by Rhodococcus sp. BCH2 to N-isopropylammelide with subsequent assessment of toxicity of biodegraded metabolites.

    PubMed

    Kolekar, Parag D; Phugare, Swapnil S; Jadhav, Jyoti P

    2014-02-01

    Atrazine is a persistent organic pollutant in the environment which affects not only terrestrial and aquatic biota but also human health. Since its removal from the environment is needed, atrazine biodegradation is achieved in the present study using the bacterium Rhodococcus sp. BCH2 isolated from soil, long-term treated with atrazine. The bacterium was capable of degrading about 75 % atrazine in liquid medium having pH 7 under aerobic and dark condition within 7 days. The degradation ability of the bacterium at various temperatures (20-60 °C), pH (range 3-11), carbon (glucose, fructose, sucrose, starch, lactose, and maltose), and nitrogen (ammonium molybdate, sodium nitrate, potassium nitrate, and urea) sources were studied for triumph optimum atrazine degradation. The results indicate that atrazine degradation at higher concentrations (100 ppm) was pH and temperature dependent. However, glucose and potassium nitrate were optimum carbon and nitrogen source, respectively. Atrazine biodegradation analysis was carried out by using high-performance thin-layer chromatography (HPTLC), Fourier transform infrared spectroscopy (FTIR), and liquid chromatography quadrupole time-of-flight (LC/Q-TOF-MS) techniques. LC/Q-TOF-MS analysis revealed formation of various intermediate metabolites including hydroxyatrazine, N-isopropylammelide, deisopropylhydroxyatrazine, deethylatrazine, deisopropylatrazine, and deisopropyldeethylatrazine which was helpful to propose biochemical degradation pathway of atrazine. Furthermore, the toxicological studies of atrazine and its biodegraded metabolites were executed on earthworm Eisenia foetida as a model organism with respect to enzymatic (SOD and Catalase) antioxidant defense mechanism and lipid peroxidation studies. These results suggest innocuous degradation of atrazine by Rhodococcus sp. BCH2 in nontoxic form. Therefore the Rhodococcus sp.BCH2 could prove a valuable source for the eco-friendly biodegradation of atrazine pesticide.

  19. SO2 control by electric utilities: What are the gains from trade?

    SciTech Connect

    Burtraw, D.; Carlson, C.; Cropper, M.; Palmer, K.

    1997-12-31

    Title IV of the 1990 Clean Air Act Amendments, which establishes a market for transferrable sulfur dioxide discharge permits (SO{sub 2} allowances), has been hailed by economists as a triumph of economic incentives over command and control regulation. The gains from using economic incentives are a reduction in the costs of pollution control: Firms operating at high marginal pollution abatement costs are supposed to purchase the right to emit SO{sub 2} from firms operating at low marginal abatement costs, with cost savings resulting as abatement shifts from high-to-low marginal cost firms. flow large are the potential cost savings from SO{sub 2} allowance trading? How many of these gains have been realized during the first year of operation of the allowance market? To answer these questions requires estimates of the marginal cost of abating SO{sub 2} emissions for all generating units affected by Title IV of the CAAA. While there have been various engineering cost estimates of abatement costs and of the gains from trade, there have been no estimates based on the actual responses of plants to changes in emissions standards and input prices. The purpose of this paper is to provide such estimates. To provide econometric estimates of marginal abatement costs and the potential gains from trade we have assembled a database covering the years 1985-94, that contains over 800 coal-fired generating units. In 1994 these units produced 87 percent of the SO{sub 2} emissions generated by all coal-fired power plants in the United States and accounted for 77 percent of the heat input consumed by all coal-fired power plants. For each generating unit we have annual observations on labor, generating capital, abatement capital, and inputs of high- and low-sulfur coal. We also know the emissions standard facing the generator, as well as its output and mean annual emissions rate. Data on input prices complete the dataset.

  20. In the ear of the beholder: how age shapes emotion processing in nonverbal vocalizations.

    PubMed

    Lima, César F; Alves, Tiago; Scott, Sophie K; Castro, São Luís

    2014-02-01

    It is well established that emotion recognition of facial expressions declines with age, but evidence for age-related differences in vocal emotions is more limited. This is especially true for nonverbal vocalizations such as laughter, sobs, or sighs. In this study, 43 younger adults (M = 22 years) and 43 older ones (M = 61.4 years) provided multiple emotion ratings of nonverbal emotional vocalizations. Contrasting with previous research, which often includes only one positive emotion (happiness) versus several negative ones, we examined 4 positive and 4 negative emotions: achievement/triumph, amusement, pleasure, relief, anger, disgust, fear, and sadness. We controlled for hearing loss and assessed general cognitive decline, cognitive control, verbal intelligence, working memory, current affect, emotion regulation, and personality. Older adults were less sensitive than younger ones to the intended vocal emotions, as indicated by decrements in ratings on the intended emotion scales and accuracy. These effects were similar for positive and negative emotions, and they were independent of age-related differences in cognitive, affective, and personality measures. Regression analyses revealed that younger and older participants' responses could be predicted from the acoustic properties of the temporal, intensity, fundamental frequency, and spectral profile of the vocalizations. The two groups were similarly efficient in using the acoustic cues, but there were differences in the patterns of emotion-specific predictors. This study suggests that ageing produces specific changes on the processing of nonverbal vocalizations. That decrements were not attenuated for positive emotions indicates that they cannot be explained by a positivity effect in older adults.