MULTI-MESSENGER ASTRONOMY OF GRAVITATIONAL-WAVE SOURCES WITH FLEXIBLE WIDE-AREA RADIO TRANSIENT SURVEYS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yancey, Cregg C.; Shawhan, Peter; Bear, Brandon E.

We explore opportunities for multi-messenger astronomy using gravitational waves (GWs) and prompt, transient low-frequency radio emission to study highly energetic astrophysical events. We review the literature on possible sources of correlated emission of GWs and radio transients, highlighting proposed mechanisms that lead to a short-duration, high-flux radio pulse originating from the merger of two neutron stars or from a superconducting cosmic string cusp. We discuss the detection prospects for each of these mechanisms by low-frequency dipole array instruments such as LWA1, the Low Frequency Array and the Murchison Widefield Array. We find that a broad range of models may bemore » tested by searching for radio pulses that, when de-dispersed, are temporally and spatially coincident with a LIGO/Virgo GW trigger within a ∼30 s time window and ∼200–500 deg{sup 2} sky region. We consider various possible observing strategies and discuss their advantages and disadvantages. Uniquely, for low-frequency radio arrays, dispersion can delay the radio pulse until after low-latency GW data analysis has identified and reported an event candidate, enabling a prompt radio signal to be captured by a deliberately targeted beam. If neutron star mergers do have detectable prompt radio emissions, a coincident search with the GW detector network and low-frequency radio arrays could increase the LIGO/Virgo effective search volume by up to a factor of ∼2. For some models, we also map the parameter space that may be constrained by non-detections.« less

Status of air-shower measurements with sparse radio arrays

NASA Astrophysics Data System (ADS)

Schröder, Frank G.

2017-03-01

This proceeding gives a summary of the current status and open questions of the radio technique for cosmic-ray air showers, assuming that the reader is already familiar with the principles. It includes recent results of selected experiments not present at this conference, e.g., LOPES and TREND. Current radio arrays like AERA or Tunka-Rex have demonstrated that areas of several km2 can be instrumented for reasonable costs with antenna spacings of the order of 200m. For the energy of the primary particle such sparse antenna arrays can already compete in absolute accuracy with other precise techniques, like the detection of air-fluorescence or air-Cherenkov light. With further improvements in the antenna calibration, the radio detection might become even more accurate. For the atmospheric depth of the shower maximum, Xmax, currently only the dense array LOFAR features a precision similar to the fluorescence technique, but analysis methods for the radio measurement of Xmax are still under development. Moreover, the combination of radio and muon measurements is expected to increase the accuracy of the mass composition, and this around-the-clock recording is not limited to clear nights as are the light-detection methods. Consequently, radio antennas will be a valuable add-on for any air shower array targeting the energy range above 100 PeV.

Study of Ultra-High Energy Cosmic Rays from Extensive Air Showers Radio Emission

NASA Astrophysics Data System (ADS)

Petrov, Igor; Kozlov, Vladimir; Petrov, Zim; Knurenko, Stanislav; Pravdin, Mikhail

The study of cosmic rays with the help of radio detection from extensive air showers may be an alternative to traditional detecting methods, which use a large area array installed with hundreds and thousands of scintillation detectors for charged particles, or the detectors of measuring the emission produced by relativistic particles of EAS in the optical wavelengths. Processes that lead to the emission of electromagnetic radiation are well known and calculations show that the air shower radio emission depends on the processes of development of the electromagnetic cascade, i.e. related with the longitudinal development of the shower, with the magnetic field near sea level etc. In this regard, there is a question to establish the correlation between characteristics of EAS both longitudinal and lateral development and radio emission parameters observed when air shower particles pass through the atmosphere. For this purpose, in Yakutsk, radio array for detecting air shower radio emission was established. The array consists of the antenna field on which crossed antennas are installed; antennas oriented E - W and N - S. Radio emission measurements are conducted at frequency 32 MHz, free from industrial noise. In 2008 - 2013 years, Yakutsk array has measured several seasons of registration of EAS events, including showers with energies above 10 (19) eV. In the course of the data analysis the following results were obtained: a) lateral distribution of the radio signal plotted as a function of distance from the shower axis ; b) a correlation between the amplitude of the radio signal with the energy of the shower, which is determined by measuring the fluxes of charged particles , muons and EAS Cerenkov radiation (energy balance method); c) we made evaluation of the depth of maximum development of the shower using form of radio emission LDF measured in ultra-high energy showers; g) a comparison of the Yakutsk array data with data from other arrays.

Radio Measurements of Air Showers with LOPES

NASA Astrophysics Data System (ADS)

Schröder, F. G.; Apel, W. D.; Arteaga-Velazquez, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Fuchs, B.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Zabierowski, J.; Zensus, J. A.

2013-02-01

LOPES is a digital antenna array for the radio measurement of cosmic-ray air showers at energies around 1017 eV. It is triggered by the KASCADE-Grande air-shower array at the Karlsruhe Institute of Technology (KIT), Germany. Because of an absolute amplitude calibration and a sophisticated data analysis, LOPES can test models for the radio emission to an up-to-now unachieved level, thus improving our understanding of the radio emission mechanisms. Recent REAS simulations of the air-shower radio emission come closer to the measurements than any previously tested simulations. We have determined the radio-reconstruction precision of interesting air-shower parameters by comparing LOPES reconstructions to both REAS simulations and KASCADE-Grande measurements, and present our latest results for the angular resolution, the energy and the Xmax reconstruction based on the radio measurement of about 500 air showers. Although the precision of LOPES is limited by the high level of anthropogenic noise at KIT, it opens a promising perspective for next-generation radio arrays in regions with a lower ambient noise level.

Radio interference in the near-earth environment

NASA Technical Reports Server (NTRS)

Erickson, W. C.

1988-01-01

Natural and man-made radio frequency interference (RFI) are potentially serious obstacles to the successful operation of an array of spacecraft used for low frequency (1 to 30 MHz) radio interferometry in the near-earth environment. Several satellites and planetary probes have carried radio astronomy experiments, and the moderate data base that they provide are examined to help understand the near-earth RFI environment. The general conclusion is that the region of space within 100 earth-radii of the earth is a hostile environment for any radio astronomy experiment. If a low frequency array in earth orbit is to yield useful astronomical results, severe interference problems must be anticipated and overcome. A number of recommendations are made to further examine the feasibility of such an array.

Experimental evidence for the sensitivity of the air-shower radio signal to the longitudinal shower development

NASA Astrophysics Data System (ADS)

Apel, W. D.; Arteaga, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuchs, B.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F. G.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2012-04-01

We observe a correlation between the slope of radio lateral distributions and the mean muon pseudorapidity of 59 individual cosmic-ray-air-shower events. The radio lateral distributions are measured with LOPES, a digital radio interferometer colocated with the multidetector-air-shower array KASCADE-Grande, which includes a muon-tracking detector. The result proves experimentally that radio measurements are sensitive to the longitudinal development of cosmic-ray air showers. This is one of the main prerequisites for using radio arrays for ultra-high-energy particle physics and astrophysics.

Intercepted signals for ionospheric science

NASA Astrophysics Data System (ADS)

Lind, F. D.; Erickson, P. J.; Coster, A. J.; Foster, J. C.; Marchese, J. R.; Berkowitz, Z.; Sahr, J. D.

2013-05-01

The ISIS array (Intercepted Signals for Ionospheric Science) is a distributed, coherent software radio array designed for the study of geospace phenomena by observing the scatter of ambient radio frequency (RF) signals. ISIS data acquisition and analysis is performed using the MIDAS-M platform (Millstone Data Acquisition System - Mobile). Observations of RF signals can be performed between HF and L-band using the Array nodes and appropriate antennas. The deployment of the Array focuses on observations of the plasmasphere boundary layer. We discuss the concept of the coherent software radio array, describe the ISIS hardware, and give examples of data from the system for selected applications. In particular, we include the first observations of E region irregularities using the Array. We also present single-site passive radar observations of both meteor trails and E region irregularities using adaptive filtering techniques.

Status of the radio technique for cosmic-ray induced air showers

NASA Astrophysics Data System (ADS)

Schröder, Frank G.

2016-10-01

Radio measurements yield calorimetric information on the electromagnetic shower component around the clock. However, until recently it was not clear whether radio measurements can compete in accuracy with established night-time techniques like air-Cherenkov or air-fluorescence detection. Due to recent progress in the radio technique as well as in the understanding of the emission mechanisms, the performance of current radio experiments has significantly improved. Above 100 PeV, digital, state-of-the-art antenna arrays achieve a reconstruction accuracy for the energy similar to that of other techniques, and can provide an independent measurement of the absolute energy scale. Furthermore, radio measurements are sensitive to the mass composition of the primary particles: First, the position of the shower maximum can be reconstructed from the radio signal. Second, in combination with muon detectors the measurement of the electromagnetic component provides complementary information on the primary mass. Since the radio footprint is huge for inclined showers, and the radio signal does not suffer absorption in the atmosphere, future radio arrays either focus on inclined showers at the highest energy, or on ultra-high precision measurements with extremely dense arrays. This proceeding reviews the current status of radio experiments and simulations as well as future plans.

Computationally Efficient Radio Frequency Source Localization for Radio Interferometric Arrays

NASA Astrophysics Data System (ADS)

Steeb, J.-W.; Davidson, David B.; Wijnholds, Stefan J.

2018-03-01

Radio frequency interference (RFI) is an ever-increasing problem for remote sensing and radio astronomy, with radio telescope arrays especially vulnerable to RFI. Localizing the RFI source is the first step to dealing with the culprit system. In this paper, a new localization algorithm for interferometric arrays with low array beam sidelobes is presented. The algorithm has been adapted to work both in the near field and far field (only the direction of arrival can be recovered when the source is in the far field). In the near field the computational complexity of the algorithm is linear with search grid size compared to cubic scaling of the state-of-the-art 3-D MUltiple SIgnal Classification (MUSIC) method. The new method is as accurate as 3-D MUSIC. The trade-off is that the proposed algorithm requires a once-off a priori calculation and storing of weighting matrices. The accuracy of the algorithm is validated using data generated by low-frequency array while a hexacopter was flying around it and broadcasting a continuous-wave signal. For the flight, the mean distance between the differential GPS positions and the corresponding estimated positions of the hexacopter is 2 m at a wavelength of 6.7 m.

Development of an Interferometric Phased Array Trigger for Balloon-Borne Detection of the Highest Energy Cosmic Particles

NASA Astrophysics Data System (ADS)

Vieregg, Abigail

Through high energy neutrino astrophysics, we explore the structure and evolution of the universe in a unique way and learn about the physics inside of astrophysical sources that drives the acceleration of the highest energy particles. Neutrinos travel virtually unimpeded through the universe, making them unique messenger particles for cosmic sources and carrying information about very distant sources that would otherwise be unavailable. The highest energy neutrinos (E>10^{18} eV), created as a by-product of the interaction of the highest energy cosmic rays with the cosmic microwave background, are an important tool for determining the origin of the highest energy cosmic rays and still await discovery. Balloon-borne and ground-based experiments are poised to discover these ultra-high energy (UHE) cosmogenic neutrinos by looking for radio emission from two different types of neutrino interactions: particle cascades induced by neutrinos in glacial ice, and extensive air showers in the atmosphere induced by the charged-particle by-product of tau neutrinos interacting in the earth. These impulsive radio detectors are also sensitive to radio emission from extensive air showers induced directly by UHE cosmic rays. Balloon-borne experiments are especially well-suited for discovering the highest energy neutrinos, and are the only way to probe the high energy cutoff of the sources themselves to reveal the astrophysics that drives the central engines inside the most energetic accelerators in the universe. Balloon platforms offer the chance to monitor extremely large volumes of ice and atmosphere, but with a higher energy threshold compared to ground-based observatories, since the neutrino interaction happens farther from the detector. This tradeoff means that the sensitivity of balloon-borne experiments, such as the Antarctic Impulsive Transient Antenna (ANITA) or the ExaVolt Antenna, is optimized for discovery of the highest energy neutrinos. We are developing an interferometric phased array trigger for these impulsive radio detectors, a new type of trigger that will improve sensitivity substantially and expedite the discovery of the highest energy particles in our universe. We have developed an 8- channel interferometric trigger board for ground-based applications that will be deployed in December 2017 with the ground-based Askaryan Radio Array (ARA) experiment at the South Pole. Preliminary Monte Carlo simulations indicate that the cosmogenic neutrino event rate will go up by a factor of 3 with the new trigger. The true power of the interferometric trigger is in scaling to large numbers of channels, and the discovery space that is only available from a balloon platform at the highest energies is extremely appealing. We will build on and extend the NASA investment in the ANITA Long Duration Balloon (LDB) mission and the many other complementary particle astrophysics LDB missions by developing the electronics required to bring a large-scale radio interferometric trigger to a balloon platform, extending the scientific reach of any future LDB or Super Pressure Balloon (SPB) mission for radio detection of the highest energy cosmic particles. We will develop an interferometric trigger system that is scalable to O(100) channels and suitable for use on a balloon platform. Under this proposal, we will: 1) Design and fabricate interferometric trigger hardware for balloon-borne cosmic particle detectors that is scalable to large numbers of channels O(100) by reducing the power consumption per channel, increasing the number of channels per board, and developing high-speed communication capability between boards. 2) Perform a trade study and inform design decisions for future balloon missions by further developing our Monte Carlo simulation and adapting it to balloon geometries.

Simulation and Testing of a Linear Array of Modified Four-Square Feed Antennas for the Tianlai Cylindrical Radio Telescope

NASA Astrophysics Data System (ADS)

Cianciara, Aleksander J.; Anderson, Christopher J.; Chen, Xuelei; Chen, Zhiping; Geng, Jingchao; Li, Jixia; Liu, Chao; Liu, Tao; Lu, Wing; Peterson, Jeffrey B.; Shi, Huli; Steffel, Catherine N.; Stebbins, Albert; Stucky, Thomas; Sun, Shijie; Timbie, Peter T.; Wang, Yougang; Wu, Fengquan; Zhang, Juyong

A wide bandwidth, dual polarized, modified four-square antenna is presented as a feed antenna for radio astronomical measurements. A linear array of these antennas is used as a line-feed for cylindrical reflectors for Tianlai, a radio interferometer designed for 21cm intensity mapping. Simulations of the feed antenna beam patterns and scattering parameters are compared to experimental results at multiple frequencies across the 650-1420MHz range. Simulations of the beam patterns of the combined feed array/reflector are presented as well.

The Southern Hemisphere VLBI experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Preston, R.A.; Meier, D.L.; Louie, A.P.

1989-07-01

Six radio telescopes were operated as the first Southern Hemisphere VLBI array in April and May 1982. Observations were made at 2.3 and 8.4 GHz. This array provided VLBI modeling and hybrid imaging of celestial radio sources in the Southern Hemisphere, high-accuracy VLBI geodesy between Southern Hemisphere sites, and subarcsecond radio astrometry of celestial sources south of declination -45 deg. The goals and implementation of the array are discussed, the methods of modeling and hybrid image production are explained, and the VLBI structure of the sources that were observed is summarized. 36 refs.

The Engineering Development Array: A Low Frequency Radio Telescope Utilising SKA Precursor Technology

NASA Astrophysics Data System (ADS)

Wayth, Randall; Sokolowski, Marcin; Booler, Tom; Crosse, Brian; Emrich, David; Grootjans, Robert; Hall, Peter J.; Horsley, Luke; Juswardy, Budi; Kenney, David; Steele, Kim; Sutinjo, Adrian; Tingay, Steven J.; Ung, Daniel; Walker, Mia; Williams, Andrew; Beardsley, A.; Franzen, T. M. O.; Johnston-Hollitt, M.; Kaplan, D. L.; Morales, M. F.; Pallot, D.; Trott, C. M.; Wu, C.

2017-08-01

We describe the design and performance of the Engineering Development Array, which is a low-frequency radio telescope comprising 256 dual-polarisation dipole antennas working as a phased array. The Engineering Development Array was conceived of, developed, and deployed in just 18 months via re-use of Square Kilometre Array precursor technology and expertise, specifically from the Murchison Widefield Array radio telescope. Using drift scans and a model for the sky brightness temperature at low frequencies, we have derived the Engineering Development Array's receiver temperature as a function of frequency. The Engineering Development Array is shown to be sky-noise limited over most of the frequency range measured between 60 and 240 MHz. By using the Engineering Development Array in interferometric mode with the Murchison Widefield Array, we used calibrated visibilities to measure the absolute sensitivity of the array. The measured array sensitivity matches very well with a model based on the array layout and measured receiver temperature. The results demonstrate the practicality and feasibility of using Murchison Widefield Array-style precursor technology for Square Kilometre Array-scale stations. The modular architecture of the Engineering Development Array allows upgrades to the array to be rolled out in a staged approach. Future improvements to the Engineering Development Array include replacing the second stage beamformer with a fully digital system, and to transition to using RF-over-fibre for the signal output from first stage beamformers.

Radio detection of high-energy cosmic rays with the Auger Engineering Radio Array

NASA Astrophysics Data System (ADS)

Schröder, Frank G.; Pierre Auger Collaboration

2016-07-01

The Auger Engineering Radio Array (AERA) is an enhancement of the Pierre Auger Observatory in Argentina. Covering about 17km2, AERA is the world-largest antenna array for cosmic-ray observation. It consists of more than 150 antenna stations detecting the radio signal emitted by air showers, i.e., cascades of secondary particles caused by primary cosmic rays hitting the atmosphere. At the beginning, technical goals had been in focus: first of all, the successful demonstration that a large-scale antenna array consisting of autonomous stations is feasible. Moreover, techniques for calibration of the antennas and time calibration of the array have been developed, as well as special software for the data analysis. Meanwhile physics goals come into focus. At the Pierre Auger Observatory air showers are simultaneously detected by several detector systems, in particular water-Cherenkov detectors at the surface, underground muon detectors, and fluorescence telescopes, which enables cross-calibration of different detection techniques. For the direction and energy of air showers, the precision achieved by AERA is already competitive; for the type of primary particle, several methods are tested and optimized. By combining AERA with the particle detectors we aim for a better understanding of cosmic rays in the energy range from approximately 0.3 to 10 EeV, i.e., significantly higher energies than preceding radio arrays.

Big-Data Perspective to Operating an SKA-Type Synthesis Array Radio Telescope

NASA Astrophysics Data System (ADS)

Shanmugha Sundaram, GA

2015-08-01

Of the two forerunner sites, viz. Australia and South Africa, where pioneering advancements to state-of-the-art in synthesis array radio astronomy instrumentation are being attempted in the form of pathfinders to the Square Kilometer Array (SKA), for its eventual deployment, a diversity of site-dependent topology and design metrics exists. Towards addressing some of the fundamental mysteries in physics at the micro- and macro-cosm levels, that form the Key Science Projects (KSPs) for the SKA, and interfacing them to an optimally designed array conguration, a critical evaluation of their radio imaging capabilities and metrics becomes paramount. Here, the various KSPs and instrument design specifications are discussed, for relative merits and adaptability to either site, from invoking well-founded and established array-design and optimization principles designed into a customized software tool. Since the problem of array design is one that encompasses variables on several scales such as separation distances between the radio interferometric pair (termed the baseline), factors such as redundancy, flux and phase calibration, bandwidth, integration time, clock synchronization for the correlation process at the detector, and many other ambient-defined parameters, there is a significant component of big data involved in the complex visibilities that are to be Fourier transformed from the spatial to the radio-sky domain (to generate a radio sky map) using vast computational infrastructure, with robust data connectivity and data handling facilities to support this. A crucial requirement exists to make the general public aware of the implications of such a massive scale scientific and technological venture, which shall be the focus of this presentation.

77 FR 17456 - Buy American Exception Under the American Recovery and Reinvestment Act of 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

...,000.00 to Adon Construction for the construction of a 120kw photovoltaic solar array system to be built in eight 15kw sub-arrays at NIST's WWVH radio station in Kauai, HI. The objective of the solar... Recovery Act), for inverters necessary for the construction of a solar array system at NIST's WWVH radio...

Direction of Radio Finding via MUSIC (Multiple Signal Classification) Algorithm for Hardware Design System

NASA Astrophysics Data System (ADS)

Zhang, Zheng

2017-10-01

Concept of radio direction finding systems, which use radio direction finding is based on digital signal processing algorithms. Thus, the radio direction finding system becomes capable to locate and track signals by the both. Performance of radio direction finding significantly depends on effectiveness of digital signal processing algorithms. The algorithm uses the Direction of Arrival (DOA) algorithms to estimate the number of incidents plane waves on the antenna array and their angle of incidence. This manuscript investigates implementation of the DOA algorithms (MUSIC) on the uniform linear array in the presence of white noise. The experiment results exhibit that MUSIC algorithm changed well with the radio direction.

The Astronomical Low Frequency Array: A Proposed Explorer Mission for Radio Astronomy

NASA Technical Reports Server (NTRS)

Jones, D.; Allen, R.; Basart, J.; Bastian, T.; Bougeret, J. L.; Dennison, B.; Desch, M.; Dwarakanath, K.; Erickson, W.; Finley, D.;

LoFASM: A Low Frequency All Sky Monitor for Radio Transients and Student Training

DTIC Science & Technology

2015-09-02

to 88 MHz) astrophysical radio transients. It consists of four geographically-separated stations, each comprising 12 phased array dipole antennas...All four stations have now started taking data. The observatory has also been a vital recruiting and training tool for physics students from the...to 88 MHz) astrophysical radio transients. It consists of four geographically-separated stations, each comprising 12 phased array dipole antennas

Surveying the Dynamic Radio Sky with the Long Wavelength Demonstrator Array

DTIC Science & Technology

2010-10-01

and potentially the Lunar Radio Array. Subject headings: instrumentation: interferometers — methods : observational — radio continuum: gen- eral 1Remote...Sensing Division, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375 USA 2NASA Lunar Science Institute, NASA Ames Research Center...Moffett Field, CA 94035 USA 3Space Science Division, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375-5382 USA 4Praxis, Inc

Editorial

NASA Astrophysics Data System (ADS)

Buitink, S.; Hörandel, J. R.; de Jong, S.; Lahmann, R.; Nahnhauer, R.; Scholten, O.

2017-03-01

This proceeding gives a summary of the current status and open questions of the radio technique for cosmic-ray air showers, assuming that the reader is already familiar with the principles. It includes recent results of selected experiments not present at this conference, e.g., LOPES and TREND. Current radio arrays like AERA or Tunka-Rex have demonstrated that areas of several km2 can be instrumented for reasonable costs with antenna spacings of the order of 200m. For the energy of the primary particle such sparse antenna arrays can already compete in absolute accuracy with other precise techniques, like the detection of air-fluorescence or air-Cherenkov light. With further improvements in the antenna calibration, the radio detection might become even more accurate. For the atmospheric depth of the shower maximum, Xmax, currently only the dense array LOFAR features a precision similar to the fluorescence technique, but analysis methods for the radio measurement of Xmax are still under development. Moreover, the combination of radio and muon measurements is expected to increase the accuracy of the mass composition, and this around-the-clock recording is not limited to clear nights as are the light-detection methods. Consequently, radio antennas will be a valuable add-on for any air shower array targeting the energy range above 100 PeV.

A decametric wavelength radio telescope for interplanetary scintillation observations

NASA Technical Reports Server (NTRS)

Cronyn, W. M.; Shawhan, S. D.

1975-01-01

A phased array, electrically steerable radio telescope (with a total collecting area of 18 acres), constructed for the purpose of remotely sensing electron density irregularity structure in the solar wind, is presented. The radio telescope is able to locate, map, and track large scale features of the solar wind, such as streams and blast waves, by monitoring a large grid of natural radio sources subject to rapid intensity fluctuation (interplanetary scintillation) caused by the irregularity structure. Observations verify the performance of the array, the receiver, and the scintillation signal processing circuitry of the telescope.

A Radio-Frequency-over-Fiber link for large-array radio astronomy applications

NASA Astrophysics Data System (ADS)

Mena, J.; Bandura, K.; Cliche, J.-F.; Dobbs, M.; Gilbert, A.; Tang, Q. Y.

2013-10-01

A prototype 425-850 MHz Radio-Frequency-over-Fiber (RFoF) link for the Canadian Hydrogen Intensity Mapping Experiment (CHIME) is presented. The design is based on a directly modulated Fabry-Perot (FP) laser, operating at ambient temperature, and a single-mode fiber. The dynamic performance, gain stability, and phase stability of the RFoF link are characterized. Tests on a two-element interferometer built at the Dominion Radio Astrophysical Observatory for CHIME prototyping demonstrate that RFoF can be successfully used as a cost-effective solution for analog signal transport on the CHIME telescope and other large-array radio astronomy applications.

Detection of Ultrahigh-Energy Cosmic Rays with the Auger Engineering Radio Array

NASA Astrophysics Data System (ADS)

Krause, Raphael; Pierre Auger Collaboration

2017-02-01

Ultrahigh-energy cosmic rays interact with the Earth's atmosphere and produce great numbers of secondary particles forming an extensive air shower. These air showers emit radiation in the radio frequency range which delivers important information about the processes of radio emission in extensive air showers and properties of the primary cosmic rays, e.g. arrival direction, energy and mass with a duty cycle close to 100%. The radio extension of the world's largest cosmic-ray experiment, the Pierre Auger Observatory, is called the Auger Engineering Radio Array (AERA). In addition to the particle and fluorescence detectors of the Pierre Auger Observatory, AERA investigates the electromagnetic component of extensive air showers using 153 autonomous radio stations on an area of 17km2 .

Early VLA and AMI-LA Radio Detections of the Nova V392 Per

NASA Astrophysics Data System (ADS)

Linford, J. D.; Bright, J.; Chomiuk, L.; Fender, R.; van der Horst, A.; Mioduszewski, A.; Sokoloski, J.; Rupen, M.; Nelson, T.; Mukai, K.

2018-05-01

We report radio observations of the young nova V392 Per (ATel #11588, ATel #11590, ATel #11601, ATel #11605, and ATel #11617) with the Karl G. Janksy Very Large Array (VLA) and the Arcminute Microkelvin Imager Large Array (AMI-LA).

The ARIANNA Hexagonal Radio Array - performance and prospects

NASA Astrophysics Data System (ADS)

Hallgren, Allan

2016-04-01

The origin of the highest energy cosmic rays at ˜1020 eV is still unknown. Ultra-high energy neutrinos from the GZK process should provide information on the sources and their properties. A promising and cost effective method for observing GZK-neutrinos is based on detection of Askaryan radio pulses with antennas installed in ice. The ARIANNA project aims at instrumenting a 36*36 km2 large area on the Ross Ice Shelf with an array of radio detection stations. The deployment of a test system for ARIANNA, the Hexagonal Radio Array (HRA), was completed in December 2014. The three first stations were installed in 2012. Solar panels are used to drive the < 10 W stations. The system hibernated at sunset in April and all stations returned to operation in September. The site is essentially free of anthropogenic noise. Simple cuts eliminate background and provides for efficient selection of neutrino events. Prospects for the sensitivity of the full ARIANNA array to the flux of GZK neutrinos are shown.

Observing Solar Radio Bursts from the Lunar Surface

NASA Technical Reports Server (NTRS)

MacDowall, R. J.; Lazio, T. J.; Bale, S. D.; Burns, J.; Gopalswamy, N.; Jones, D. L.; Kaiser, M. L.; Kasper, J.; Weiler, K. W.

2010-01-01

Locating low frequency radio observatories on the lunar surface has a number of advantages. Here, we describe the Radio Observatory for Lunar Sortie Science (ROLSS), a concept for a low frequency, radio imaging interferometric array designed to study particle acceleration in the corona and inner heliosphere. ROLSS would be deployed during an early lunar sortie or by a robotic rover as part of an unmanned landing. The prime science mission is to image type II and type III solar radio bursts with the aim of determining the sites at and mechanisms by which the radiating particles are accelerated. Secondary science goals include constraining the density of the lunar ionosphere by searching for a low radio frequency cutoff of the solar radio emissions and constraining the low energy electron population in astrophysical sources. Furthermore, ROLSS serves a pathfinder function for larger lunar radio arrays. Key design requirements on ROLES include the operational frequency and angular resolution. The electron densities in the solar corona and inner heliosphere are such that the relevant emission occurs below 10 MHz, essentially unobservable from Earth's surface due to the terrestrial ionospheric cutoff. Resolving the potential sites of particle acceleration requires an instrument with an angular resolution of at least 2 deg, equivalent to a linear array size of approximately 500 meters. Operations would consist of data acquisition during the lunar day, with regular data downlinks. The major components of the ROLSS array are 3 antenna arms arranged in a Y shape, with a central electronics package (CEP). Each antenna arm is a linear strip of polyimide film (e.g., Kapton (TM)) on which 16 single polarization dipole antennas are located by depositing a conductor (e.g., silver). The arms also contain transmission lines for carrying the radio signals from the science antennas to the CEP.

Toward a Cosmic Dawn Mapper

NASA Astrophysics Data System (ADS)

Bowman, Judd D.

2018-06-01

After stars formed in the early universe, their ultraviolet light altered the 21cm hyperfine state of hydrogen atoms, causing the atoms to absorb photons from the cosmic microwave background. The EDGES experiment has reported evidence for this signal as a decrease in the sky-averaged radio intensity observed today as a broad feature centered at 78 MHz due to cosmological redshift, corresponding to an age of about 200 million years after the Big Bang. Ground-based radio arrays are expected soon to detect and eventually to characterize the power spectrum of spatial fluctuations of the 21cm absorption signal. However, the Earth’s ionosphere and radio transmitters, particularly those in the FM radio band, will complicate the observations and likely will limit the ultimate goal of imaging the era of cosmic dawn in detail. A radio array in lunar orbit or on the lunar suface would avoid the limitations imposed by Earth ionosphere’s. The Moon’s farside is also uniquely shielded from human-generated radio interference. Locating the radio observatory on the lunar surface compared to orbit has potential advantages, including fixed locations for the antennas that require no propulsion to maintain and simpler operations. The lunar surface poses unique challenges for instruments, including surviving the 14-day lunar night when there is no sunlight and temperatures can fall to 100 K. Building on lessons from ground based arrays and design studies from the last decade that led to the Dark Ages Lunar Interferometer and the Lunar Array for Radio Cosmology concepts, we are exploring a trade space for key lunar array technology. Our trade space includes choices related to: 1) antenna design for optimizing sensitivity and mass, while maintaining mechanical and thermal stability and enabling cost-effective deployment scenarios; 2) location of the array on the lunar surface to provide an efficient observing paradigm and suitable environmental conditions; 3) data transportation and processing for collecting antenna measurements at a central location for correlation and reduction; and 4) power and environmental requirements. In this talk, I will report the status of these ongoing studies.

Large-N correlator systems for low frequency radio astronomy

NASA Astrophysics Data System (ADS)

Foster, Griffin

Low frequency radio astronomy has entered a second golden age driven by the development of a new class of large-N interferometric arrays. The low frequency array (LOFAR) and a number of redshifted HI Epoch of Reionization (EoR) arrays are currently undergoing commission and regularly observing. Future arrays of unprecedented sensitivity and resolutions at low frequencies, such as the square kilometer array (SKA) and the hydrogen epoch of reionization array (HERA), are in development. The combination of advancements in specialized field programmable gate array (FPGA) hardware for signal processing, computing and graphics processing unit (GPU) resources, and new imaging and calibration algorithms has opened up the oft underused radio band below 300 MHz. These interferometric arrays require efficient implementation of digital signal processing (DSP) hardware to compute the baseline correlations. FPGA technology provides an optimal platform to develop new correlators. The significant growth in data rates from these systems requires automated software to reduce the correlations in real time before storing the data products to disk. Low frequency, widefield observations introduce a number of unique calibration and imaging challenges. The efficient implementation of FX correlators using FPGA hardware is presented. Two correlators have been developed, one for the 32 element BEST-2 array at Medicina Observatory and the other for the 96 element LOFAR station at Chilbolton Observatory. In addition, calibration and imaging software has been developed for each system which makes use of the radio interferometry measurement equation (RIME) to derive calibrations. A process for generating sky maps from widefield LOFAR station observations is presented. Shapelets, a method of modelling extended structures such as resolved sources and beam patterns has been adapted for radio astronomy use to further improve system calibration. Scaling of computing technology allows for the development of larger correlator systems, which in turn allows for improvements in sensitivity and resolution. This requires new calibration techniques which account for a broad range of systematic effects.

Measurement of horizontal air showers with the Auger Engineering Radio Array

NASA Astrophysics Data System (ADS)

Kambeitz, Olga

2017-03-01

The Auger Engineering Radio Array (AERA), at the Pierre Auger Observatory in Argentina, measures the radio emission of extensive air showers in the 30-80 MHz frequency range. AERA consists of more than 150 antenna stations distributed over 17 km2. Together with the Auger surface detector, the fluorescence detector and the underground muon detector (AMIGA), AERA is able to measure cosmic rays with energies above 1017 eV in a hybrid detection mode. AERA is optimized for the detection of air showers up to 60° zenith angle, however, using the reconstruction of horizontal air showers with the Auger surface array, very inclined showers can also be measured. In this contribution an analysis of the AERA data in the zenith angle range from 62° to 80° will be presented. CoREAS simulations predict radio emission footprints of several km2 for horizontal air showers, which are now confirmed by AERA measurements. This can lead to radio-based composition measurements and energy determination of horizontal showers in the future and the radio detection of neutrino induced showers is possible.

Observations of Interplanetary Scintillation (IPS) Using the Mexican Array Radio Telescope (MEXART)

NASA Astrophysics Data System (ADS)

Mejia-Ambriz, J. C.; Villanueva-Hernandez, P.; Gonzalez-Esparza, J. A.; Aguilar-Rodriguez, E.; Jeyakumar, S.

2010-08-01

The Mexican Array Radio Telescope (MEXART) consists of a 64×64 (4096) full-wavelength dipole antenna array, operating at 140 MHz, with a bandwidth of 2 MHz, occupying about 9660 square meters (69 m × 140 m) ( http://www.mexart.unam.mx ). This is a dedicated radio array for Interplanetary Scintillation (IPS) observations located at latitude 19°48'N, longitude 101°41'W. We characterize the performance of the system. We report the first IPS observations with the instrument, employing a Butler Matrix (BM) of 16×16 ports, fed by 16 east - west lines of 64 dipoles (1/4 of the total array). The BM displays a radiation pattern of 16 beams at different declinations (from -48, to +88 degrees). We present a list of 19 strong IPS radio sources (having at least 3 σ in power gain) detected by the instrument. We report the power spectral analysis procedure of the intensity fluctuations. The operation of MEXART will allow us a better coverage of solar wind disturbances, complementing the data provided by the other, previously built, instruments.

IEEE Radio and Wireless Symposium Student Awards Support Request: 2010-2012

DTIC Science & Technology

2012-01-01

Reconfigurable Architecture Enabling All-Digital Transmission for Cognitive Radios ……..3 Ultra-Wide Band Vivaldi Antenna Array using Low Loss SIW Power...1431714191, Iran 2University of Tennessee, Knoxville, TN, 37996, US Ultra-Wide Band Vivaldi Antenna Array using Low Loss SIW Power Divider and GCPW Wide

Optoelectronic Infrastructure for Radio Frequency and Optical Phased Arrays

NASA Technical Reports Server (NTRS)

Cai, Jianhong

2015-01-01

Optoelectronic integrated circuits offer radiation-hardened solutions for satellite systems in addition to improved size, weight, power, and bandwidth characteristics. ODIS, Inc., has developed optoelectronic integrated circuit technology for sensing and data transfer in phased arrays. The technology applies integrated components (lasers, amplifiers, modulators, detectors, and optical waveguide switches) to a radio frequency (RF) array with true time delay for beamsteering. Optical beamsteering is achieved by controlling the current in a two-dimensional (2D) array. In this project, ODIS integrated key components to produce common RF-optical aperture operation.

Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.

PubMed

Blankestijn, M A; Otten, H G; Suer, W; Weimann, A; Knol, E F; Knulst, A C

2018-01-01

Little is known on the clinical relevance of peanut 2S albumin Ara h 7. To investigate the discriminative ability of Ara h 7 in peanut allergy and assess the role of cross-reactivity between Ara h 2, 6 and Ara h 7 isoforms. Sensitization to recombinant peanut storage proteins Ara h 1, 2, 3, 6, and 7 was assessed using a line blot in sera from 40 peanut-tolerant and 40 peanut-allergic patients, based on food challenge outcome. A dose-dependent ELISA inhibition experiment was performed with recombinant Ara h 2, 6 and Ara h 7 isoforms. For Ara h 7.0201, an area under the ROC curve was found of 0.83, comparable to Ara h 2 (AUC 0.81) and Ara h 6 (AUC 0.85). Ara h 7 intensity values strongly correlated with those from Ara h 2 and 6 (r s = 0.81). Of all patients sensitized to 2S albumins Ara h 2, 6, or 7, the majority was co-sensitized to all three (n = 24, 68%), although mono-sensitization to either 2S albumin was also observed in selected patients (Ara h 2: n = 6, 17%; Ara h 6: n = 2, 6%; Ara h 7: n = 2, 6%). Binding to Ara h 7.0101 could be strongly inhibited by Ara h 7.0201, but not the other way around. Specific IgE against Ara h 7.0201 has a predictive ability for peanut allergy similar to Ara h 2 and 6 and possesses unique IgE epitopes as well as epitopes shared between the other Ara h 7 isoform and Ara h 2 and 6. While co-sensitization to all three 2S albumins is most common, mono-sensitization to either Ara h 2, 6, or 7 occurs in selected patients, leading to a risk of misdiagnosis when testing for a single 2S albumin. © 2017 John Wiley & Sons Ltd.

Simulating 3D Spacecraft Constellations for Low Frequency Radio Imaging

NASA Astrophysics Data System (ADS)

Hegedus, A. M.; Amiri, N.; Lazio, J.; Belov, K.; Kasper, J. C.

2016-12-01

Constellations of small spacecraft could be used to realize a low-frequency phased array for either heliophysics or astrophysics observations. However, there are issues that arise with an orbiting array that do not occur on the ground, thus rendering much of the existing radio astronomy software inadequate for data analysis and simulation. In this work we address these issues and consider the performance of two constellation concepts. The first is a 32-spacecraft constellation for astrophysical observations, and the second is a 5-element concept for pointing to the location of radio emission from coronal mass ejections (CMEs). For the first, we fill the software gap by extending the APSYNSIM software to simulate the aperture synthesis for a radio interferometer in orbit. This involves using the dynamic baselines from the relative motion of the individual spacecraft as well as the capability to add galactic noise. The ability to simulate phase errors corresponding to positional uncertainty of the antennas was also added. The upgraded software was then used to model the imaging of a 32 spacecraft constellation that would orbit the moon to image radio galaxies like Cygnus A at .3-30 MHz. Animated images showing the improvement of the dirty image as the orbits progressed were made. RMSE plots that show how well the dirty image matches the input image as a function of integration time were made. For the second concept we performed radio interferometric simulations of the Sun Radio Interferometer Space Experiment (SunRISE) using the Common Astronomy Software Applications (CASA) package. SunRISE is a five spacecraft phased array that would orbit Earth to localize the low frequency radio emission from CMEs. This involved simulating the array in CASA, creating truth images for the CMEs over the entire frequency band of SunRISE, and observing them with the simulated array to see how well it could localize the true position of the CME. The results of our analysis show that we can localize the radio emission originating from the head or flanks of the CMEs in spite of the phase errors introduced by uncertainties in orbit and clock estimation.

Big data challenges for large radio arrays

NASA Astrophysics Data System (ADS)

Jones, D. L.; Wagstaff, K.; Thompson, D. R.; D'Addario, L.; Navarro, R.; Mattmann, C.; Majid, W.; Lazio, J.; Preston, J.; Rebbapragada, U.

2012-03-01

Future large radio astronomy arrays, particularly the Square Kilometre Array (SKA), will be able to generate data at rates far higher than can be analyzed or stored affordably with current practices. This is, by definition, a "big data" problem, and requires an end-to-end solution if future radio arrays are to reach their full scientific potential. Similar data processing, transport, storage, and management challenges face next-generation facilities in many other fields. The Jet Propulsion Laboratory is developing technologies to address big data issues, with an emphasis in three areas: 1) Lower-power digital processing architectures to make highvolume data generation operationally affordable, 2) Date-adaptive machine learning algorithms for real-time analysis (or "data triage") of large data volumes, and 3) Scalable data archive systems that allow efficient data mining and remote user code to run locally where the data are stored.

International Conference on Antennas and Propagation (ICAP 89), 6th, University of Warwick, Coventry, England, Apr. 4-7, 1989, Proceedings. Part 1 - Antennas. Part 2 - Propagation

NASA Astrophysics Data System (ADS)

Various papers on antennas and propagation are presented. The general topics addressed include: phased arrays; reflector antennas; slant path propagation; propagation data for HF radio systems performance; satellite and earth station antennas; radio propagation in the troposphere; propagation data for HF radio systems performance; microstrip antennas; rain radio meteorology; conformal antennas; horns and feed antennas; low elevation slant path propagation; radio millimeter wave propagation; array antennas; propagation effects on satellite mobile, satellite broadcast, and aeronautical systems; ionospheric irregularities and motions; adaptive antennas; transient response; measurement techniques; clear air radio meteorology; ionospheric and propagation modeling; millimeter wave and lens antennas; electromagnetic theory and numerical techniques; VHF propagation modeling, system planning methods; radio propagation theoretical techniques; scattering and diffraction; transhorizon rain scatter effects; ELF-VHF and broadcast antennas; clear air millimeter propagation; scattering and frequency-selective surfaces; antenna technology; clear air transhorizon propagation.

A Large Array of Small Antennas to Support Future NASA Missions

NASA Astrophysics Data System (ADS)

Jones, D. L.; Weinreb, S.; Preston, R. A.

2001-01-01

A team of engineers and scientists at JPL is currently working on the design of an array of small radio antennas with a total collecting area up to twenty times that of the largest existing (70 m) DSN antennas. An array of this size would provide obvious advantages for high data rate telemetry reception and for spacecraft navigation. Among these advantages are an order-of-magnitude increase in sensitivity for telemetry downlink, flexible sub-arraying to track multiple spacecraft simultaneously, increased reliability through the use of large numbers of identical array elements, very accurate real-time angular spacecraft tracking, and a dramatic reduction in cost per unit area. NASA missions in many disciplines, including planetary science, would benefit from this increased DSN capability. The science return from planned missions could be increased, and opportunities for less expensive or completely new kinds of missions would be created. The DSN array would also bean immensely valuable instrument for radio astronomy. Indeed, it would be by far the most sensitive radio telescope in the world. Additional information is contained in the original extended abstract.

The Gould's Belt very large array survey. III. The Orion region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kounkel, Marina; Hartmann, Lee; Loinard, Laurent

2014-07-20

We present results from a high-sensitivity (60 μJy), large-scale (2.26 deg{sup 2}) survey obtained with the Karl G. Jansky Very Large Array as part of the Gould's Belt Survey program. We detected 374 and 354 sources at 4.5 and 7.5 GHz, respectively. Of these, 148 are associated with previously known young stellar objects (YSOs). Another 86 sources previously unclassified at either optical or infrared wavelengths exhibit radio properties that are consistent with those of young stars. The overall properties of our sources at radio wavelengths such as their variability and radio to X-ray luminosity relation are consistent with previous resultsmore » from the Gould's Belt Survey. Our detections provide target lists for follow-up Very Long Baseline Array radio observations to determine their distances as YSOs are located in regions of high nebulosity and extinction, making it difficult to measure optical parallaxes.« less

The Gould's Belt Very Large Array Survey. III. The Orion Region

NASA Astrophysics Data System (ADS)

Kounkel, Marina; Hartmann, Lee; Loinard, Laurent; Mioduszewski, Amy J.; Dzib, Sergio A.; Ortiz-León, Gisela N.; Rodríguez, Luis F.; Pech, Gerardo; Rivera, Juana L.; Torres, Rosa M.; Boden, Andrew F.; Evans, Neal J., II; Briceño, Cesar; Tobin, John

2014-07-01

We present results from a high-sensitivity (60 μJy), large-scale (2.26 deg2) survey obtained with the Karl G. Jansky Very Large Array as part of the Gould's Belt Survey program. We detected 374 and 354 sources at 4.5 and 7.5 GHz, respectively. Of these, 148 are associated with previously known young stellar objects (YSOs). Another 86 sources previously unclassified at either optical or infrared wavelengths exhibit radio properties that are consistent with those of young stars. The overall properties of our sources at radio wavelengths such as their variability and radio to X-ray luminosity relation are consistent with previous results from the Gould's Belt Survey. Our detections provide target lists for follow-up Very Long Baseline Array radio observations to determine their distances as YSOs are located in regions of high nebulosity and extinction, making it difficult to measure optical parallaxes.

Multi-epoch Measurements of the Galactic Center 6667 MHz) and the Blazar 0716+714 (1 & 3 MHz) taken from the Allen Telescope Array at Hat Creek Radio Observatory in 2013

NASA Astrophysics Data System (ADS)

Castellanos, Aaron; Harp, G.

2014-01-01

The Allen Telescope Array (ATA) is a 42 radio dish array located in Hat Creek, CA and is used to search for traces of Extraterrestrial Intelligence (SETI) and to study the interstellar medium. The ATA has taken multi-epoch measurements of the Galactic Center 6667 MHz) and the intraday variable Blazar 0716+714 (1 & 3MHz) and are imaged on 10 second timescales to search for intensity fluctuations on timescales 10s and beyond. We utilize software developed and focused on antenna system temperatures to minimize Radio Frequency Interference (RFI) in order to enhance calibration and signal variability. We will discuss potential radio bursts from the Galactic Center, possibly originating from the descent of the gas cloud G2 into the Galactic Center.

The effects of correlated noise in phased-array observations of radio sources

NASA Technical Reports Server (NTRS)

Dewey, Rachel J.

1994-01-01

Arrays of radio telescopes are now routinely used to provide increased signal-to-noise when observing faint point sources. However, calculation of the achievable sensitivity is complicated if there are sources in the field of view other than the target source. These additional sources not only increase the system temperatures of the individual antennas, but may also contribute significant 'correlated noise' to the effective system temperature of the array. This problem has been of particular interest in the context of tracking spacecraft in the vicinity of radio-bright planets (e.g., Galileo at Jupiter), but it has broader astronomical relevance as well. This paper presents a general formulation of the problem, for the case of a point-like target source in the presence of an additional radio source of arbitrary brightness distribution. We re-derive the well known result that, in the absence of any background sources, a phased array of N indentical antennas is a factor of N more sensitive than a single antenna. We also show that an unphased array of N identical antennas is, on average, no more sensitive than a single antenna if the signals from the individual antennas are combined prior to detection. In the case where a background source is present we show that the effects of correlated noise are highly geometry dependent, and for some astronomical observations may cause significant fluctuations in the array's effective system temperature.

Study of Radio sources and interferences detected by MEXART

NASA Astrophysics Data System (ADS)

Villanueva Hernandez, P.; Gonzalez Esparza, J. A.; Carrillo, A.; Andrade, E.; Jeyacumar, S.; Kurtz, S.

2007-05-01

The Mexican Array Radio Telescope (MEXART) is a radio telescope that will perform studies of solar wind disturbances using the Interplanetary Scintillation (IPS) technique. The radiotelescope is its final calibration stage, and in this work we report two testings: the interference signals detected around the operation frequency, and the transit of the main radio sources detected by individual lines of 64 dipoles. These radio sources are: Sun, Casiopea, Crab nebula, Cygnus and Virgo. These testings allow us to know the response of the array elements in order to calibrate them. The final operation of the MEXART requires that the signal detected and transmitted by each East-West line of 64 dipoles arrives at the butler matrix (control room) with the same phase and amplitude.

Radio emission of energetic cosmic ray air showers: Polarization measurements with LOPES

NASA Astrophysics Data System (ADS)

Lopes Collaboration; Isar, P. G.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Auffenberg, J.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huang, X.; Huege, T.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Kolotaev, Y.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.; LOPES Collaboration

2009-06-01

LOPES is a radio antenna array co-located with the Karlsruhe Shower Core and Array DEtector, KASCADE-Grande in Forschungszentrum Karlsruhe, Germany, which provides well-calibrated trigger information and air shower parameters for primary energies up to 10eV. By the end of 2006, the radio antennas were re-configured to perform polarization measurements of the radio signal of cosmic ray air showers, recording in the same time both, the East-West and North-South polarization directions of the radio emission. The main goal of these measurements is to reconstruct the polarization characteristics of the emitted signal. This will allow a detailed comparison with theoretical predictions. The current status of these measurements is reported here.

Calibration Test of an Interplanetary Scintillation Array in Mexico

NASA Astrophysics Data System (ADS)

Carrillo, A.; Gonzalez-Esparza, A.; Andrade, E.; Ananthakrishnan, S.; Praveen-Kumar, A.; Balasubramanian, V.

We report the calibration test of a radiotelecope to carry out interplanetary scintillation (IPS) observations in Mexico. This will be a dedicate (24 hrs) radio array for IPS observations of nearly 1000 well know radio sources in the sky to perform solar wind studies. The IPS array is located in the state of Michoacan at 350 km north-west from Mexico City, (19'48 degrees north and 101'41 degrees west, 2000 meters above the sea level). The radiotelescope operates in 140 MHz with a bandwith of 1.5 MHz. The antenna is a planar array with 64 X 64 full wavelength dipoles along 64 east-west rows of open wire transmission lines, occupying 10,000 square meters (70 x 140 m). We report the final testings of the antenna array, the matrix Butler and receivers. This work is a collaboration between the Universidad Nacional Autonoma de Mexico (UNAM) and the National Centre for Radio Astrophysics (NCRA), India. We expect to initiate the firs IPS observations by the end of this year.

Isoforms of the major peanut allergen Ara h 2: IgE binding in children with peanut allergy.

PubMed

Hales, Belinda J; Bosco, Anthony; Mills, Kristina L; Hazell, Lee A; Loh, Richard; Holt, Patrick G; Thomas, Wayne R

2004-10-01

The major peanut allergen Ara h 2 consists of two isoforms, namely Ara h 2.0101 and Ara h 2.0201. The recently identified Ara h 2.0201 isoform contains an extra 12 amino acids including an extra copy of the reported immunodominant epitope DPYSPS. This study aimed to evaluate the IgE binding of the two Ara h 2 isoforms. Ten clones of Ara h 2 were sequenced to assess the relative frequency of the Ara h 2 isoforms and to identify whether there was further variation in the Ara h 2 sequence. IgE binding to Ara h 2.0101 and Ara h 2.0201 was measured for 70 peanut-allergic children using an IgE DELFIA assay to quantitate specific IgE binding. A competition assay was used to measure whether Ara h 2.0201 contained IgE epitopes other than those found for Ara h 2.0101. The original Ara h 2.0101 sequence was found for 6/10 clones and Ara h 2.0201 was found for 2/10 clones. Ara h 2.0201 had the expected insertion of 12 amino acids as well as substitutions at positions 40 (40G) and 142 (142E). Two new isoforms were identified as different polymorphisms of position 142. One Ara h 2.01 clone (Ara h 2.0102) contained 142E and one Ara h 2.02 clone (Ara h 2.0202) contained 142D. A polymorphism that was previously identified by other investigators at position 77 (77Q or 77R) was not found for any of the 10 sequences. Although the level of IgE binding to Ara h 2.0201 of individual patients was frequently higher than the binding to Ara h 2.0101 (p < 0.01), there was a strong correlation in binding to both isoforms (r = 0.987, p < 0.0001) and when analyzed as a group the means were similar. Ara h 2.0101 was not as efficient at blocking reactivity to Ara h 2.0201 indicating there is an additional IgE specificity for the Ara h 2.0201 isoform. Ara h 2.0201 has similar but higher IgE binding than the originally sequenced Ara h 2.0101 isoform and contains other IgE specificities.

N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury

PubMed Central

Cohen-Yeshurun, Ayelet; Willner, Dafna; Trembovler, Victoria; Alexandrovich, Alexander; Mechoulam, Raphael; Shohami, Esther; Leker, Ronen R

2013-01-01

N-arachidonoyl-L-serine (AraS) is a novel neuroprotective endocannabinoid. We aimed to test the effects of exogenous AraS on neurogenesis after traumatic brain injury (TBI). The effects of AraS on neural progenitor cells (NPC) proliferation, survival, and differentiation were examined in vitro. Next, mice underwent TBI and were treated with AraS or vehicle. Lesion volumes and clinical outcome were evaluated and the effects on neurogenesis were tested using immunohistochemistry. Treatment with AraS led to a dose-dependent increase in neurosphere size without affecting cell survival. These effects were partially reversed by CB1, CB2, or TRPV1 antagonists. AraS significantly reduced the differentiation of NPC in vitro to astrocytes or neurons and led to a 2.5-fold increase in expression of the NPC marker nestin. Similar effects were observed in vivo in mice treated with AraS 7 days after TBI. These effects were accompanied by a reduction in lesion volume and an improvement in neurobehavioral function compared with controls. AraS increases proliferation of NPCs in vitro in cannabinoid-receptor-mediated mechanisms and maintains NPC in an undifferentiated state in vitro and in vivo. Moreover, although given at 7 days post injury, these effects are associated with significant neuroprotective effects leading to an improvement in neurobehavioral functions. PMID:23695434

N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury.

PubMed

Cohen-Yeshurun, Ayelet; Willner, Dafna; Trembovler, Victoria; Alexandrovich, Alexander; Mechoulam, Raphael; Shohami, Esther; Leker, Ronen R

2013-08-01

N-arachidonoyl-L-serine (AraS) is a novel neuroprotective endocannabinoid. We aimed to test the effects of exogenous AraS on neurogenesis after traumatic brain injury (TBI). The effects of AraS on neural progenitor cells (NPC) proliferation, survival, and differentiation were examined in vitro. Next, mice underwent TBI and were treated with AraS or vehicle. Lesion volumes and clinical outcome were evaluated and the effects on neurogenesis were tested using immunohistochemistry. Treatment with AraS led to a dose-dependent increase in neurosphere size without affecting cell survival. These effects were partially reversed by CB1, CB2, or TRPV1 antagonists. AraS significantly reduced the differentiation of NPC in vitro to astrocytes or neurons and led to a 2.5-fold increase in expression of the NPC marker nestin. Similar effects were observed in vivo in mice treated with AraS 7 days after TBI. These effects were accompanied by a reduction in lesion volume and an improvement in neurobehavioral function compared with controls. AraS increases proliferation of NPCs in vitro in cannabinoid-receptor-mediated mechanisms and maintains NPC in an undifferentiated state in vitro and in vivo. Moreover, although given at 7 days post injury, these effects are associated with significant neuroprotective effects leading to an improvement in neurobehavioral functions.

Observing Solar Radio Bursts from the Lunar Surface

NASA Technical Reports Server (NTRS)

MacDowall, R. J.; Gopalswamy, N.; Kaiser, M. L.; Lazio, T. J.; Jones, D. L.; Bale, S. D.; Burns, J.; Kasper, J. C.; Weiler, K. W.

2011-01-01

Locating low frequency radio observatories on the lunar surface has a number of advantages, including fixes locations for the antennas and no terrestrial interference on the far side of the moon. Here, we describe the Radio Observatory for Lunar Sortie Science (ROLSS), a concept for a low frequency, radio imaging interferometric array designed to study particle acceleration in the corona and inner heliosphere. ROLSS would be deployed during an early lunar sortie or by a robotic rover as part of an unmanned landing. The prime science mission is to image type II and type III solar radio bursts with the aim of determining the sites at and mechanisms by which the radiating particles are accelerated. Secondary science goals include constraining the density of the lunar ionosphere by searching for a low radio frequency cutoff of the solar radio emissions and constraining the low energy electron population in astrophysical sources. Furthermore, ROLSS serves a pathfinder function for larger lunar radio arrays designed for faint sources.

Medicina array demonstrator: calibration and radiation pattern characterization using a UAV-mounted radio-frequency source

NASA Astrophysics Data System (ADS)

Pupillo, G.; Naldi, G.; Bianchi, G.; Mattana, A.; Monari, J.; Perini, F.; Poloni, M.; Schiaffino, M.; Bolli, P.; Lingua, A.; Aicardi, I.; Bendea, H.; Maschio, P.; Piras, M.; Virone, G.; Paonessa, F.; Farooqui, Z.; Tibaldi, A.; Addamo, G.; Peverini, O. A.; Tascone, R.; Wijnholds, S. J.

2015-06-01

One of the most challenging aspects of the new-generation Low-Frequency Aperture Array (LFAA) radio telescopes is instrument calibration. The operational LOw-Frequency ARray (LOFAR) instrument and the future LFAA element of the Square Kilometre Array (SKA) require advanced calibration techniques to reach the expected outstanding performance. In this framework, a small array, called Medicina Array Demonstrator (MAD), has been designed and installed in Italy to provide a test bench for antenna characterization and calibration techniques based on a flying artificial test source. A radio-frequency tone is transmitted through a dipole antenna mounted on a micro Unmanned Aerial Vehicle (UAV) (hexacopter) and received by each element of the array. A modern digital FPGA-based back-end is responsible for both data-acquisition and data-reduction. A simple amplitude and phase equalization algorithm is exploited for array calibration owing to the high stability and accuracy of the developed artificial test source. Both the measured embedded element patterns and calibrated array patterns are found to be in good agreement with the simulated data. The successful measurement campaign has demonstrated that a UAV-mounted test source provides a means to accurately validate and calibrate the full-polarized response of an antenna/array in operating conditions, including consequently effects like mutual coupling between the array elements and contribution of the environment to the antenna patterns. A similar system can therefore find a future application in the SKA-LFAA context.

92. ARAIII. Overall view of GCRE area in 1959. From ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

92. ARA-III. Overall view of GCRE area in 1959. From left to right: ARA-607 (control building), ARA-608 (with high-bay, reactor building), ARA-610 (service building), ARA-609 (guard house), ARA-709 (water storage tank) ARA-710 in front of ARA-709 (fuel oil tank), ARA-611 (well pumphouse), and the cooling tower. Note petro-chem stack and other stacks emerging from reactor building. Camera facing northeast. August 1959. Ineel photo no. 59-4444. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Future Trends in Solar Radio Astronomy and Coronal Magnetic-Field Measurements

NASA Astrophysics Data System (ADS)

Fleishman, Gregory; Nita, Gelu; Gary, Dale

Solar radio astronomy has an amazingly rich, but yet largely unexploited, potential for probing the solar corona and chromosphere. Radio emission offers multiple ways of detecting and tracking electron beams, studying chromospheric and coronal thermal structure, plasma processes, particle acceleration, and measuring magnetic fields. To turn the mentioned potential into real routine diagnostics, two major components are needed: (1) well-calibrated observations with high spatial, spectral, and temporal resolutions and (2) accurate and reliable theoretical models and fast numerical tools capable of recovering the emission source parameters from the radio data. This report gives a brief overview of the new, expanded, and planned radio facilities, such as Expanded Owens Valley Solar Array (EOVSA), Jansky Very Large Array (JVLA), Chinese Solar Radio Heliograph (CSRH), Upgraded Siberian Solar Radio Telescope (USSRT), and Frequency Agile Solar Radiotelescope (FASR) with the emphasis on their ability to measure the coronal magnetic fields in active regions and flares. In particular, we emphasize the new tools for 3D modeling of the radio emission and forward fitting tools in development needed to derive the magnetic field data from the radio measurements.

46. ARAI. Aerial view of ARAI buildings as they looked ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. ARA-I. Aerial view of ARA-I buildings as they looked in 1981. From left to right, buildings are tank (ARA-727), contaminated waste storage tank (ARA-629), trailer, hot cell building (ARA-626), fuel oil storage tank (ARA-728), guard house (ARA-628), shop and maintenance building (ARA-627), and two trailers. Ineel photo no. 81-297. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

The double quasar 0957+561: examination of the gravitational lens hypothesis using the very large array.

PubMed

Greenfield, P E; Roberts, D H; Burke, B F

1980-05-02

A full 12-hour synthesis at 6-centimeter wavelength with the Very Large Array confirms the major features previously reported for the double quasar 0957+561. In addition, the existence of radio jets apparently associated with both quasars is demonstrated. Gravitational lens models are now favored on the basis of recent optical observations, and the radio jets place severe constraints on such models. Further radio observations of the double quasar are needed to establish the expected relative time delay in variations between the images.

Extragalactic radio surveys in the pre-Square Kilometre Array era

PubMed Central

2017-01-01

The era of the Square Kilometre Array is almost upon us, and pathfinder telescopes are already in operation. This brief review summarizes our current knowledge of extragalactic radio sources, accumulated through six decades of continuum surveys at the low-frequency end of the electromagnetic spectrum and the extensive complementary observations at other wavelengths necessary to gain this understanding. The relationships between radio survey data and surveys at other wavelengths are discussed. Some of the outstanding questions are identified and prospects over the next few years are outlined. PMID:28791175

Science with a lunar low-frequency array: From the dark ages of the Universe to nearby exoplanets

NASA Astrophysics Data System (ADS)

Jester, Sebastian; Falcke, Heino

2009-05-01

Low-frequency radio astronomy is limited by severe ionospheric distortions below 50 MHz and complete reflection of radio waves below 10-30 MHz. Shielding of man-made interference from long-range radio broadcasts, strong natural radio emission from the Earth's aurora, and the opportunity to set up a large distributed antenna array make the lunar far side a supreme location for a low-frequency radio array. A number of new scientific drivers for such an array, such as the study of the dark ages and epoch of reionization, exoplanets, and ultra-high energy cosmic rays, have emerged and need to be studied in greater detail. Here we review the scientific potential and requirements of these new scientific drivers and discuss the constraints for various lunar surface arrays. In particular, we describe observability constraints imposed by the interstellar and interplanetary medium, calculate the achievable resolution, sensitivity, and confusion limit of a dipole array using general scaling laws, and apply them to various scientific questions. Of particular interest for a lunar array are studies of the earliest phase of the universe which are not easily accessible by other means. These are the epoch of reionization at redshifts z = 6-20, during which the very first stars and galaxies ionized most of the originally neutral intergalactic hydrogen, and the dark ages prior to that. For example, a global 21-cm wave absorption signature from primordial hydrogen in the dark ages at z = 30-50 could in principle be detected by a single dipole in an eternally dark crater on the moon, but foreground subtraction would be extremely difficult. Obtaining a high-quality power spectrum of density fluctuations in the epoch of reionization at z = 6-20, providing a wealth of cosmological data, would require about 103-105 antenna elements on the moon, which appears not unreasonable in the long term. Moreover, baryonic acoustic oscillations in the dark ages at z = 30-50 could similarly be detected, thereby providing pristine cosmological information, e.g., on the inflationary phase of the universe. With a large array also exoplanet magnetospheres could be detected through Jupiter-like coherent bursts. Smaller arrays of order 102 antennas over ˜100 km, which could already be erected robotically by a single mission with current technology and launchers, could tackle surveys of steep-spectrum large-scale radio structures from galaxy clusters and radio galaxies. Also, at very low frequencies the structure of the interstellar medium can be studied tomographically. Moreover, radio emission from neutrino interactions within the moon can potentially be used to create a neutrino detector with a volume of several cubic kilometers. An ultra-high energy cosmic ray detector with thousands of square kilometer area for cosmic ray energies >1020eV could in principle be realized with some hundred antennas. In any case, pathfinder arrays are needed to test the feasibility of these experiments in the not too distant future. Lunar low-frequency arrays are thus a timely option to consider, offering the potential for significant new insights into a wide range of today's crucial scientific topics. This would open up one of the last unexplored frequency domains in the electromagnetic spectrum.

Pulsars Probe the Low-Frequency Gravitational Sky: Pulsar Timing Arrays Basics and Recent Results

NASA Astrophysics Data System (ADS)

Tiburzi, Caterina

2018-03-01

Pulsar Timing Array experiments exploit the clock-like behaviour of an array of millisecond pulsars, with the goal of detecting low-frequency gravitational waves. Pulsar Timing Array experiments have been in operation over the last decade, led by groups in Europe, Australia, and North America. These experiments use the most sensitive radio telescopes in the world, extremely precise pulsar timing models and sophisticated detection algorithms to increase the sensitivity of Pulsar Timing Arrays. No detection of gravitational waves has been made to date with this technique, but Pulsar Timing Array upper limits already contributed to rule out some models of galaxy formation. Moreover, a new generation of radio telescopes, such as the Five hundred metre Aperture Spherical Telescope and, in particular, the Square Kilometre Array, will offer a significant improvement to the Pulsar Timing Array sensitivity. In this article, we review the basic concepts of Pulsar Timing Array experiments, and discuss the latest results from the established Pulsar Timing Array collaborations.

Radio Jove: Citizen Science for Jupiter Radio Astronomy

NASA Astrophysics Data System (ADS)

Higgins, C. A.; Thieman, J.; Reyes, F. J.; Typinski, D.; Flagg, R. F.; Greenman, W.; Brown, J.; Ashcraft, T.; Sky, J.; Cecconi, B.; Garcia, L. N.

2016-12-01

The Radio Jove Project (http://radiojove.gsfc.nasa.gov) has been operating as an educational activity for 18 years to introduce radio astronomy activities to students, teachers, and the general public. Participants may build a simple radio telescope kit, make scientific observations, and interact with radio observatories in real-time over the Internet. Recently some of our dedicated citizen science observers have upgraded their systems to better study radio emission from Jupiter and the Sun by adding dual-polarization spectrographs and wide-band antennas in the frequency range of 15-30 MHz. Some of these observations are being used in conjunction with professional telescopes such as the Long Wavelength Array (LWA), the Nancay Decametric Array, and the Ukrainian URAN2 Radio Telescope. In particular, there is an effort to support the Juno Mission radio waves instrument at Jupiter by using citizen science ground-based data for comparison and polarization verification. These data will be archived through a Virtual European Solar and Planetary Access (VESPA) archive (https://voparis-radiojove.obspm.fr/radiojove/welcome) for use by the amateur and professional radio science community. We overview the program and display recent observations that will be of interest to the science community.

Interagency telemetry arraying for Voyager-Neptune encounter

NASA Technical Reports Server (NTRS)

Brown, D. W.; Brundage, W. D.; Ulvestad, J. S.; Kent, S. S.; Bartos, K. P.

1990-01-01

The reception capability of the Deep Space Network (DSN) has been improved over the years by increasing both the size and number of antennas at each complex to meet spacecraft-support requirements. However, even more aperture was required for the final planetary encounters of the Voyager 2 spacecraft. This need was met by arraying one radio astronomy observatory with the DSN complex in the United States and another with the complex in Australia. Following a review of augmentation for the Uranus encounter, both the preparation at the National Radio Astronomy (NRAO) Very Large Array (VLA) and the Neptune encounter results for the Parkes-Canberra and VLA-Goldstone arrays are presented.

A lunar far-side very low frequency array

NASA Technical Reports Server (NTRS)

Burns, Jack O. (Editor); Duric, Nebojsa (Editor); Johnson, Stewart (Editor); Taylor, G. Jeffrey (Editor)

1989-01-01

Papers were presented to consider very low frequency (VLF) radio astronomical observations from the moon. In part 1, the environment in which a lunar VLF radio array would function is described. Part 2 is a review of previous and proposed low-frequency observatories. The science that could be conducted with a lunar VLF array is described in part 3. The design of a lunar VLF array and site selection criteria are considered, respectively, in parts 4 and 5. Part 6 is a proposal for precursor lunar VLF observations. Finally, part 7 is a summary and statement of conclusions, with suggestions for future science and engineering studies. The workshop concluded with a general consensus on the scientific goals and preliminary design for a lunar VLF array.

The Murchison Widefield Array: solar science with the low frequency SKA Precursor

NASA Astrophysics Data System (ADS)

Tingay, S. J.; Oberoi, D.; Cairns, I.; Donea, A.; Duffin, R.; Arcus, W.; Bernardi, G.; Bowman, J. D.; Briggs, F.; Bunton, J. D.; Cappallo, R. J.; Corey, B. E.; Deshpande, A.; deSouza, L.; Emrich, D.; Gaensler, B. M.; R, Goeke; Greenhill, L. J.; Hazelton, B. J.; Herne, D.; Hewitt, J. N.; Johnston-Hollitt, M.; Kaplan, D. L.; Kasper, J. C.; Kennewell, J. A.; Kincaid, B. B.; Koenig, R.; Kratzenberg, E.; Lonsdale, C. J.; Lynch, M. J.; McWhirter, S. R.; Mitchell, D. A.; Morales, M. F.; Morgan, E.; Ord, S. M.; Pathikulangara, J.; Prabu, T.; Remillard, R. A.; Rogers, A. E. E.; Roshi, A.; Salah, J. E.; Sault, R. J.; Udaya-Shankar, N.; Srivani, K. S.; Stevens, J.; Subrahmanyan, R.; Waterson, M.; Wayth, R. B.; Webster, R. L.; Whitney, A. R.; Williams, A.; Williams, C. L.; Wyithe, J. S. B.

2013-06-01

The Murchison Widefield Array is a low frequency (80 - 300 MHz) SKA Precursor, comprising 128 aperture array elements (known as tiles) distributed over an area of 3 km diameter. The MWA is located at the extraordinarily radio quiet Murchison Radioastronomy Observatory in the mid-west of Western Australia, the selected home for the Phase 1 and Phase 2 SKA low frequency arrays. The MWA science goals include: 1) detection of fluctuations in the brightness temperature of the diffuse redshifted 21 cm line of neutral hydrogen from the epoch of reionisation; 2) studies of Galactic and extragalactic processes based on deep, confusion-limited surveys of the full sky visible to the array; 3) time domain astrophysics through exploration of the variable radio sky; and 4) solar imaging and characterisation of the heliosphere and ionosphere via propagation effects on background radio source emission. This paper concentrates on the capabilities of the MWA for solar science and summarises some of the solar science results to date, in advance of the initial operation of the final instrument in 2013.

Imaging of Stellar Surfacess Using Radio Facilities Including ALMA

NASA Astrophysics Data System (ADS)

O'Gorman, Eamon

2018-04-01

Until very recently, studies focusing on imaging stars at continuum radio wavelengths (here defined as submillimeter, millimeter, and centimeter wavelengths) has been scarce. These studies have mainly been carried out with the Very Large Array on a handful of evolved stars (i.e., Asymptotic Giant Branch and Red Supergiant stars) whereby their stellar disks have just about been spatially resolved. Some of these results however, have challenged our historical views on the nature of evolved star atmospheres. Now, the very long baselines of the Atacama Large Millimeter/submillimeter Array and the newly upgraded Karl G. Jansky Very Large Array provide a new opportunity to image these atmospheres at unprecedented spatial resolution and sensitivity across a much wider portion of the radio spectrum. In this talk I will first provide a history of stellar radio imaging and then discuss some recent exciting ALMA results. Finally I will present some brand new multi-wavelength ALMA and VLA results for the famous red supergiant Antares.

Developments of FPGA-based digital back-ends for low frequency antenna arrays at Medicina radio telescopes

NASA Astrophysics Data System (ADS)

Naldi, G.; Bartolini, M.; Mattana, A.; Pupillo, G.; Hickish, J.; Foster, G.; Bianchi, G.; Lingua, A.; Monari, J.; Montebugnoli, S.; Perini, F.; Rusticelli, S.; Schiaffino, M.; Virone, G.; Zarb Adami, K.

In radio astronomy Field Programmable Gate Array (FPGA) technology is largely used for the implementation of digital signal processing techniques applied to antenna arrays. This is mainly due to the good trade-off among computing resources, power consumption and cost offered by FPGA chip compared to other technologies like ASIC, GPU and CPU. In the last years several digital backend systems based on such devices have been developed at the Medicina radio astronomical station (INAF-IRA, Bologna, Italy). Instruments like FX correlator, direct imager, beamformer, multi-beam system have been successfully designed and realized on CASPER (Collaboration for Astronomy Signal Processing and Electronics Research, https://casper.berkeley.edu) processing boards. In this paper we present the gained experience in this kind of applications.

IgE cross-reactivity between the major peanut allergen Ara h 2 and the non-homologous allergens Ara h 1 and Ara h 3

USDA-ARS?s Scientific Manuscript database

Ara h 1, a vicilin, Ara h 2, a 2S albumin, and Ara h 3, a legumin, are major33 peanut allergens. Ara h 2 is an important predictor of clinical reactivity to peanut, but co-sensitization to all three allergens is correlated with the severity of patients’ symptoms. We investigated whether co-sensitiza...

Heliophysics Radio Observations Enabled by the Deep Space Gateway

NASA Astrophysics Data System (ADS)

Kasper, J. C.

2018-02-01

This presentation reviews the scientific potential of low frequency radio imaging from space, the SunRISE radio interferometer, and the scientific value of larger future arrays in deep space and how they would benefit from the Deep Space Gateway.

Fish-Eye Observing with Phased Array Radio Telescopes

NASA Astrophysics Data System (ADS)

Wijnholds, S. J.

The radio astronomical community is currently developing and building several new radio telescopes based on phased array technology. These telescopes provide a large field-of-view, that may in principle span a full hemisphere. This makes calibration and imaging very challenging tasks due to the complex source structures and direction dependent radio wave propagation effects. In this thesis, calibration and imaging methods are developed based on least squares estimation of instrument and source parameters. Monte Carlo simulations and actual observations with several prototype show that this model based approach provides statistically and computationally efficient solutions. The error analysis provides a rigorous mathematical framework to assess the imaging performance of current and future radio telescopes in terms of the effective noise, which is the combined effect of propagated calibration errors, noise in the data and source confusion.

Radio Frequency Interference Detection using Machine Learning.

NASA Astrophysics Data System (ADS)

Mosiane, Olorato; Oozeer, Nadeem; Aniyan, Arun; Bassett, Bruce A.

2017-05-01

Radio frequency interference (RFI) has plagued radio astronomy which potentially might be as bad or worse by the time the Square Kilometre Array (SKA) comes up. RFI can be either internal (generated by instruments) or external that originates from intentional or unintentional radio emission generated by man. With the huge amount of data that will be available with up coming radio telescopes, an automated aproach will be required to detect RFI. In this paper to try automate this process we present the result of applying machine learning techniques to cross match RFI from the Karoo Array Telescope (KAT-7) data. We found that not all the features selected to characterise RFI are always important. We further investigated 3 machine learning techniques and conclude that the Random forest classifier performs with a 98% Area Under Curve and 91% recall in detecting RFI.

40. ARAIII Prototype assembly and evaluation building ARA630. East end ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. ARA-III Prototype assembly and evaluation building ARA-630. East end and south side of building. Camera facing west. Roof railing is part of demolition preparations. Building beyond ARA-622 is ARA-621. In left of view is reactor building. ARA-607 is low-roofed portion, while high-bay portion is ARA-608. Ineel photo no. 3-27. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Reminiscences regarding Professor R.N. Christiansen

NASA Astrophysics Data System (ADS)

Swarup, Govind

2008-11-01

In this short paper I describe my initiation into the field of radio astronomy fifty years ago, under the guidance of Professor W.N. ('Chris') Christiansen, soon after I joined the C.S.I.R.O.'s Division of Radiophysics (RP) in Sydney, Australia, in 1953 under a 2-year Colombo Plan Fellowship. During the early 1950s Christiansen had developed a remarkable 21 cm interferometric grating array of 32 east-west aligned parabolic dishes and another array of 16 dishes in a north-south direction at Potts Hill. Christiansen and Warburton used these two arrays to scan the Sun strip-wise yielding radio brightness distribution at various position angles. During a three month period I assisted them in making a 2-dimensional map of the Sun by a complex Fourier transform process. In the second year of my Fellowship, Parthasarathy and I converted the 32-antenna east-west grating array to study solar radio emission at 60cm. During this work, I noticed that the procedure adopted by Christiansen for phase adjustment of the grating array was time consuming. Based on this experience, I later developed an innovative technique at Stanford in 1959 for phase adjustment of long transmission lines and paths in space. In a bid to improve on the method used by Christiansen to make a 2-dimensional map of the Sun from strip scans, I suggested to R.N. Bracewell in 1962 a revolutionary method for direct 2-dimensional imaging without Fourier transforms. Bracewell and Riddle developed the method for making a 2-dimensional map of the Moon using strip scans obtained with the 32 element interferometer at Stanford. The method has since revolutionized medical tomography. I describe these developments here to highlight my initial work with Christiansen and to show how new ideas often are developed by necessity and have their origin in prior experience! The 32 Potts Hill solar grating array dishes were eventually donated by the C.S.I.R.0. to India and were set up by me at Kalyan near Mumbai, forming the core of the first radio astronomy group in India. This group went on to construct two of the world's largest radio telescopes, the Ooty Radio Telescope and the Giant Metrewave Radio Telescope. Chris Christiansen was not only my guru but also a mentor and a friend for more than fifty years. I fondly remember his very warm personality.

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.

PubMed

Milman, Garry; Maor, Yehoshua; Abu-Lafi, Saleh; Horowitz, Michal; Gallily, Ruth; Batkai, Sandor; Mo, Fong-Ming; Offertaler, Laszlo; Pacher, Pal; Kunos, George; Mechoulam, Raphael

2006-02-14

The endocannabinoid N-arachidonoyl ethanolamine (anandamide), found both in the CNS and in the periphery, plays a role in numerous physiological systems. One might expect that the chemically related N-arachidonoyl-L-serine (ARA-S) could also be formed alongside anandamide. We have now isolated ARA-S from bovine brain and elucidated its structure by comparison with synthetic ARA-S. Contrary to anandamide, ARA-S binds very weakly to cannabinoid CB1 and CB2 or vanilloid TRPV1 (transient receptor potential vanilloid 1) receptors. However, it produces endothelium-dependent vasodilation of rat isolated mesenteric arteries and abdominal aorta and stimulates phosphorylation of p44/42 mitogen-activated protein (MAP) kinase and protein kinase B/Akt in cultured endothelial cells. ARA-S also suppresses LPS-induced formation of TNF-alpha in a murine macrophage cell line and in wild-type mice, as well as in mice deficient in CB1 or CB2 receptors. Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor.

A New Wideband, Fully Steerable, Decametric Array at Clark Lake

NASA Technical Reports Server (NTRS)

Erickson, W. C.; Fisher, J. R.

1974-01-01

A fully steerable, decametric array for radio astronomy is under construction at the Clark Lake Radio Observatory near Borrego Springs, California. This array will be a T of 720 conical spiral antennas (teepee-shaped antennas, hence the array is called the TPT), 3.0 km by 1.8 km capable of operating between 15 and 125 MHz. Both its operating frequency and beam position will be adjustable in less than one millisecond, and the TPT will provide a 49-element picture around the central beam position for extended source observations. Considerable experience was gained in the operation of completed portions of the array, and successful operation of the final array is assured. The results are described of the tests which were conducted with the conical spirals, and the planned electronics and data processing systems are described.

Progress on the Low Frequency All Sky Monitor

NASA Astrophysics Data System (ADS)

Ford, Anthony; Jenet, F.; Craig, J.; Creighton, T. D.; Dartez, L. P.; Hicks, B.; Hinojosa, J.; Jaramillo, R.; Kassim, N. E.; Lunsford, G.; Miller, R. B.; Murray, J.; Ray, P. S.; Rivera, J.; Taylor, G. B.

2013-01-01

The Low Frequency All Sky Monitor is a system of geographically separated radio arrays dedicated to the study of radio transients. LoFASM consists of four stations, each comprised of 12 cross-dipole antennas designed to operate between 5-88MHz. The antennas and front end electronics for LoFASM were designed by the Naval Research Laboratory for the Long Wavelength Array project. Over the last year, undergraduate students from the University of Texas at Brownsville’s Center for Advanced Radio Astronomy have been establishing these stations around the continental US, consisting of sites located in Port Mansfield, Texas, the LWA North Arm site of the LWA1 Radio Observatory in New Mexico, adjacent to the North Arm of the Very Large Array, the Green Bank Radio Observatory, West Virginia, and NASA’s Goldstone tracking complex in California. In combination with the establishment of these sites was the development of the analog hardware, which consists of commercial off-the-shelf RF splitter/combiners and a custom amplifier and filter chain designed by colleagues at the University of New Mexico. This poster will expound on progress in site installation and development of the analog signal chain.

IN SITU AND SOIL DECONTAMINATION BY RADIO FREQUENCY HEATING

EPA Science Inventory

In situ radio frequency heating is performed by applying electromagnetic energy in the radio frequency band to an array of electrodes placed in bore holes drilled through the contaminated soil. he process removes organic contaminants from large volumes of soil by volatilization, ...

High Angular Resolution Imaging of Solar Radio Bursts from the Lunar Surface

NASA Technical Reports Server (NTRS)

MacDowall, Robert J.; Lazio, Joseph; Bale, Stuart; Burns, Jack O.; Farrell, William M.; Gopalswamy, Nat; Jones, Dayton L.; Kasper, Justin Christophe; Weiler, Kurt

2012-01-01

Locating low frequency radio observatories on the lunar surface has a number of advantages, including positional stability and a very low ionospheric radio cutoff. Here, we describe the Radio Observatory on the lunar Surface for Solar studies (ROLSS), a concept for a low frequency, radio imaging interferometric array designed to study particle acceleration in the corona and inner heliosphere. ROLSS would be deployed during an early lunar sortie or by a robotic rover as part of an unmanned landing. The preferred site is on the lunar near side to simplify the data downlink to Earth. The prime science mission is to image type II and type III solar radio bursts with the aim of determining the sites at and mechanisms by which the radiating particles are accelerated. Secondary science goals include constraining the density of the lunar ionosphere by measuring the low radio frequency cutoff of the solar radio emissions or background galactic radio emission, measuring the flux, particle mass, and arrival direction of interplanetary and interstellar dust, and constraining the low energy electron population in astrophysical sources. Furthermore, ROLSS serves a pathfinder function for larger lunar radio arrays. Key design requirements on ROLSS include the operational frequency and angular resolution. The electron densities in the solar corona and inner heliosphere are such that the relevant emission occurs below 10 M Hz, essentially unobservable from Earth's surface due to the terrestrial ionospheric cutoff. Resolving the potential sites of particle acceleration requires an instrument with an angular resolution of at least 2 deg at 10 MHz, equivalent to a linear array size of approximately one kilometer. The major components of the ROLSS array are 3 antenna arms, each of 500 m length, arranged in a Y formation, with a central electronics package (CEP) at their intersection. Each antenna arm is a linear strip of polyimide film (e.g., Kapton(TradeMark)) on which 16 single polarization dipole antennas are located by depositing a conductor (e.g., silver). The arms also contain transmission lines for carrying the radio signals from the science antennas to the CEP. Operations would consist of data acquisition during the lunar day, with data downlinks to Earth one or more times every 24 hours.

2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity.

PubMed

Hayen, S M; Ehlers, A M; den Hartog Jager, C F; Garssen, J; Knol, E F; Knulst, A C; Suer, W; Willemsen, L E M; Otten, H G

2018-07-01

Screening for specific IgE against 2S albumin proteins Ara h 2 and 6 has good positive predictive value in diagnosing peanut allergy. From the third 2S member Ara h 7, 3 isoforms have been identified. Their allergenicity has not been elucidated. This study investigated the allergenicity of Ara h 7 isoforms compared to Ara h 2 and 6. Sensitization of 15 DBPCFC-confirmed peanut-allergic patients to recombinant Ara h 2.0201, Ara h 6.01 and isoforms of recombinant Ara h 7 was determined by IgE immunoblotting strips. A basophil activation test (BAT) was performed in 9 patients to determine IgE-cross-linking capacities of the allergens. Sensitivity to the allergens was tested in 5 patients who were sensitized to at least 1 Ara h 7 isoform, by a concentration range in the BAT. 3D prediction models and sequence alignments were used to visualize differences between isoforms and to predict allergenic epitope regions. Sensitization to Ara h 7.0201 was most frequent (80%) and showed to be equally potent as Ara h 2.0201 and 6.01 in inducing basophil degranulation. Sensitization to Ara h 7.0201 together with Ara h 2.0201 and/or 6.01 was observed, indicating the presence of unique epitopes compared to the other 2 isoforms. Differences between the 3 Ara h 7 isoforms were observed in C-terminal cysteine residues, pepsin and trypsin cleavage sites and 3 single amino acid substitutions. The majority of peanut-allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C-terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy. © 2018 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.

The Challenges of Low-Frequency Radio Polarimetry: Lessons from the Murchison Widefield Array

NASA Astrophysics Data System (ADS)

Lenc, E.; Anderson, C. S.; Barry, N.; Bowman, J. D.; Cairns, I. H.; Farnes, J. S.; Gaensler, B. M.; Heald, G.; Johnston-Hollitt, M.; Kaplan, D. L.; Lynch, C. R.; McCauley, P. I.; Mitchell, D. A.; Morgan, J.; Morales, M. F.; Murphy, Tara; Offringa, A. R.; Ord, S. M.; Pindor, B.; Riseley, C.; Sadler, E. M.; Sobey, C.; Sokolowski, M.; Sullivan, I. S.; O'Sullivan, S. P.; Sun, X. H.; Tremblay, S. E.; Trott, C. M.; Wayth, R. B.

2017-09-01

We present techniques developed to calibrate and correct Murchison Widefield Array low-frequency (72-300 MHz) radio observations for polarimetry. The extremely wide field-of-view, excellent instantaneous (u, v)-coverage and sensitivity to degree-scale structure that the Murchison Widefield Array provides enable instrumental calibration, removal of instrumental artefacts, and correction for ionospheric Faraday rotation through imaging techniques. With the demonstrated polarimetric capabilities of the Murchison Widefield Array, we discuss future directions for polarimetric science at low frequencies to answer outstanding questions relating to polarised source counts, source depolarisation, pulsar science, low-mass stars, exoplanets, the nature of the interstellar and intergalactic media, and the solar environment.

N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties

PubMed Central

Milman, Garry; Maor, Yehoshua; Abu-Lafi, Saleh; Horowitz, Michal; Gallily, Ruth; Batkai, Sandor; Mo, Fong-Ming; Offertaler, Laszlo; Pacher, Pal; Kunos, George; Mechoulam, Raphael

2006-01-01

The endocannabinoid N-arachidonoyl ethanolamine (anandamide), found both in the CNS and in the periphery, plays a role in numerous physiological systems. One might expect that the chemically related N-arachidonoyl-l-serine (ARA-S) could also be formed alongside anandamide. We have now isolated ARA-S from bovine brain and elucidated its structure by comparison with synthetic ARA-S. Contrary to anandamide, ARA-S binds very weakly to cannabinoid CB1 and CB2 or vanilloid TRPV1 (transient receptor potential vanilloid 1) receptors. However, it produces endothelium-dependent vasodilation of rat isolated mesenteric arteries and abdominal aorta and stimulates phosphorylation of p44/42 mitogen-activated protein (MAP) kinase and protein kinase B/Akt in cultured endothelial cells. ARA-S also suppresses LPS-induced formation of TNF-α in a murine macrophage cell line and in wild-type mice, as well as in mice deficient in CB1 or CB2 receptors. Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor. PMID:16467152

NRL Fact Book

DTIC Science & Technology

1968-03-15

Phased array techniques Studies of the ionosphere by means of radar and satellite transmissions Radar measurements of satellites and ballistic missiles...Funding Fiscal Year 1968: $6,100,000 3-13 Radio Division Dr. L. B. Wetzel NA VIGA IOA S YS TE RADIO RESEARCH FACILITY eCOMMUNICATION *RADIO TECHNIQUES

Low-frequency Radio Observatory on the Lunar Surface (LROLS)

NASA Astrophysics Data System (ADS)

MacDowall, Robert; Network for Exploration and Space Science (NESS)

2018-06-01

A radio observatory on the lunar surface will provide the capability to image solar radio bursts and other sources. Radio burst imaging will improve understanding of radio burst mechanisms, particle acceleration, and space weather. Low-frequency observations (less than ~20 MHz) must be made from space, because lower frequencies are blocked by Earth’s ionosphere. Solar radio observations do not mandate an observatory on the farside of the Moon, although such a location would permit study of less intense solar bursts because the Moon occults the terrestrial radio frequency interference. The components of the lunar radio observatory array are: the antenna system consisting of 10 – 100 antennas distributed over a square kilometer or more; the system to transfer the radio signals from the antennas to the central processing unit; electronics to digitize the signals and possibly to calculate correlations; storage for the data until it is down-linked to Earth. Such transmission requires amplification and a high-gain antenna system or possibly laser comm. For observatories on the lunar farside a satellite or other intermediate transfer system is required to direct the signal to Earth. On the ground, the aperture synthesis analysis is completed to display the radio image as a function of time. Other requirements for lunar surface systems include the power supply, utilizing solar arrays with batteries to maintain the system at adequate thermal levels during the lunar night. An alternative would be a radioisotope thermoelectric generator requiring less mass. The individual antennas might be designed with their own solar arrays and electronics to transmit data to the central processing unit, but surviving lunar night would be a challenge. Harnesses for power and data transfer from the central processing unit to the antennas are an alternative, but a harness-based system complicates deployment. The concept of placing the antennas and harnesses on rolls of polyimide and rolling them out may be a solution for solar radio observations, but it probably does not provide a sufficiently-uniform beam for other science targets.

High-energy sources at low radio frequency: the Murchison Widefield Array view of Fermi blazars

DOE PAGES

Giroletti, M.; Massaro, F.; D’Abrusco, R.; ...

2016-04-01

Low-frequency radio arrays are opening a new window for the study of the sky, both to study new phenomena and to better characterize known source classes. Being flat-spectrum sources, blazars are so far poorly studied at low radio frequencies. In this paper, we characterize the spectral properties of the blazar population at low radio frequency, compare the radio and high-energy properties of the gamma-ray blazar population, and search for radio counterparts of unidentified gamma-ray sources. We cross-correlated the 6100 deg 2 Murchison Widefield Array Commissioning Survey catalogue with the Roma blazar catalogue, the third catalogue of active galactic nuclei detectedmore » by Fermi-LAT, and the unidentified members of the entire third catalogue of gamma-ray sources detected by Fermi-LAT. When available, we also added high-frequency radio data from the Australia Telescope 20 GHz catalogue. We find low-frequency counterparts for 186 out of 517 (36%) blazars, 79 out of 174 (45%) gamma-ray blazars, and 8 out of 73 (11%) gamma-ray blazar candidates. The mean low-frequency (120–180 MHz) blazar spectral index is (α low) = 0.57 ± 0.02: blazar spectra are flatter than the rest of the population of low-frequency sources, but are steeper than at ~GHz frequencies. Low-frequency radio flux density and gamma-ray energy flux display a mildly significant and broadly scattered correlation. Ten unidentified gamma-ray sources have a (probably fortuitous) positional match with low radio frequency sources. Low-frequency radio astronomy provides important information about sources with a flat radio spectrum and high energy. However, the relatively low sensitivity of the present surveys still misses a significant fraction of these objects. Finally, upcoming deeper surveys, such as the GaLactic and Extragalactic All-Sky MWA (GLEAM) survey, will provide further insight into this population.« less

High-energy sources at low radio frequency: the Murchison Widefield Array view of Fermi blazars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giroletti, M.; Massaro, F.; D’Abrusco, R.

Low-frequency radio arrays are opening a new window for the study of the sky, both to study new phenomena and to better characterize known source classes. Being flat-spectrum sources, blazars are so far poorly studied at low radio frequencies. In this paper, we characterize the spectral properties of the blazar population at low radio frequency, compare the radio and high-energy properties of the gamma-ray blazar population, and search for radio counterparts of unidentified gamma-ray sources. We cross-correlated the 6100 deg 2 Murchison Widefield Array Commissioning Survey catalogue with the Roma blazar catalogue, the third catalogue of active galactic nuclei detectedmore » by Fermi-LAT, and the unidentified members of the entire third catalogue of gamma-ray sources detected by Fermi-LAT. When available, we also added high-frequency radio data from the Australia Telescope 20 GHz catalogue. We find low-frequency counterparts for 186 out of 517 (36%) blazars, 79 out of 174 (45%) gamma-ray blazars, and 8 out of 73 (11%) gamma-ray blazar candidates. The mean low-frequency (120–180 MHz) blazar spectral index is (α low) = 0.57 ± 0.02: blazar spectra are flatter than the rest of the population of low-frequency sources, but are steeper than at ~GHz frequencies. Low-frequency radio flux density and gamma-ray energy flux display a mildly significant and broadly scattered correlation. Ten unidentified gamma-ray sources have a (probably fortuitous) positional match with low radio frequency sources. Low-frequency radio astronomy provides important information about sources with a flat radio spectrum and high energy. However, the relatively low sensitivity of the present surveys still misses a significant fraction of these objects. Finally, upcoming deeper surveys, such as the GaLactic and Extragalactic All-Sky MWA (GLEAM) survey, will provide further insight into this population.« less

Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays.

PubMed

Schocker, Frauke; Scharf, Alexandra; Kull, Skadi; Jappe, Uta

2017-01-01

Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. For the quantification of the marker allergens Ara h 2 and Ara h 6 in the low nanogram per milliliter range in breast milk samples of a German cohort, sensitive and highly specific sandwich ELISAs were optimized and validated. The Ara h 2 ELISA revealed a limit of detection (LOD) of 1.3 ng Ara h 2/mL and a quantification range of 2.3-250 ng/mL, the Ara h 6 ELISA showed an LOD of 0.7 ng/mL and a working range of 1.1-14.4 ng/mL. The assays showed no relevant cross-reactivity against other potentially cross-reactive legume, seed, and tree nut extracts (<0.01%, except for Ara h 1 in the Ara h 2 ELISA <0.1%). Ara h 2 was detectable in breast milk samples from 14/40 (35%) of the participants in concentrations from 2.3 to 184 ng/mL, Ara h 6 appeared in 9/40 (22.5%) of the lactating mothers between 1.1 and 9.7 ng/mL, and 1 highly positive sample with 79 ng/mL. Both allergens appeared at the same time points, but Ara h 6 in lower concentrations than Ara h 2. Sensitive and specific diagnostic tools for the determination of Ara h 2 and Ara h 6 in human breast milk were established. The kinetics of secreted Ara h 2 and Ara h 6 seem to be similar but with a difference in concentration. Follow-up investigations on their tolerogenic or sensitizing properties in breast milk become now accessible. © 2017 S. Karger AG, Basel.

A Turnover in the Radio Light Curve of GW170817

NASA Astrophysics Data System (ADS)

Dobie, Dougal; Kaplan, David L.; Murphy, Tara; Lenc, Emil; Mooley, Kunal P.; Lynch, Christene; Corsi, Alessandra; Frail, Dale; Kasliwal, Mansi; Hallinan, Gregg

2018-05-01

We present 2–9 GHz radio observations of GW170817 covering the period 125–200 days post-merger, taken with the Australia Telescope Compact Array (ATCA) and the Karl G. Jansky Very Large Array (VLA). Our observations demonstrate that the radio afterglow peaked at 149 ± 2 days post-merger and is now declining in flux density. We see no evidence for evolution in the radio-only spectral index, which remains consistent with optically thin synchrotron emission connecting the radio, optical, and X-ray regimes. The peak implies a total energy in the synchrotron-emitting component of a few × 1050 erg. The temporal decay rate is most consistent with mildly or non-relativistic material and we do not see evidence for a very energetic off-axis jet, but we cannot distinguish between a lower-energy jet and more isotropic emission.

Radio-continuum survey of the Coma/A1367 supercluster. IV - 1.4 GHz observations of CGCG galaxies

NASA Astrophysics Data System (ADS)

del Castillo, E.; Gavazzi, G.; Jaffe, W.

1988-05-01

1.4 GHz radio-continuum observations of 148 CGCG galaxies in the Coma supercluster region were obtained with the VLA in C array configuration. Comparison with previous measurements at 0.6 GHz leads to an average spectral index >α< = 0.8. The structures of 29 galaxies in this region determined with high-resolution VLA (A array) observations are presented.

Direction-dependent Corrections in Polarimetric Radio Imaging. I. Characterizing the Effects of the Primary Beam on Full-Stokes Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jagannathan, P.; Bhatnagar, S.; Rau, U.

Next generation radio telescope arrays are being designed and commissioned to accurately measure polarized intensity and rotation measures (RMs) across the entire sky through deep, wide-field radio interferometric surveys. Radio interferometer dish antenna arrays are affected by direction-dependent (DD) gains due to both instrumental and atmospheric effects. In this paper, we demonstrate the effect of DD errors of the parabolic dish antenna array on the measured polarized intensities of radio sources in interferometric images. We characterize the extent of polarimetric image degradation due to the DD gains through wide-band VLA simulations of representative point-source simulations of the radio sky atmore » L band (1–2 GHz). We show that at the 0.5 gain level of the primary beam there is significant flux leakage from Stokes I to Q , U amounting to 10% of the total intensity. We further demonstrate that while the instrumental response averages down for observations over large parallactic angle intervals, full-polarization DD correction is required to remove the effects of DD leakage. We also explore the effect of the DD beam on the RM signals and show that while the instrumental effect is primarily centered around 0 rad-m{sup −2}, the effect is significant over a broad range of RM requiring full polarization DD correction to accurately reconstruct the RM synthesis signal.« less

VizieR Online Data Catalog: Radio-loud AGN with relativistic jets (Olguin-Iglesias+, 2016)

NASA Astrophysics Data System (ADS)

Olguin-Iglesias, A.; Leon-Tavares, J.; Kotilainen, J. K.; Chavushyan, V.; Tornikoski, M.; Valtaoja, E.; Anorve, C.; Valdes, J.; Carrasco, L.

2017-11-01

The sample of sources analysed in this work is a sub-sample of variable radio-loud AGN monitored at 7mm (S7mm>1Jy) with the Aalto University Metsahovi Radio Observatory, in Finland (http://metsahovi.aalto.fi/en/) since the last 30 years (Terasranta et al., 1992A&AS...94..121T; Teraesranta et al., 1998, Cat. J/A+AS/132/305; Leon-Tavares et al., 2011A&A...532A.146L; Nieppola et al., 2011, Cat. J/A+A/535/A69). According to the AGN unification scheme (Antonucci, 1993ARA&A..31..473A; Urry & Padovani, 1995PASP..107..803U), FSRQ and BL Lacs are those AGN whose relativistic jets point towards the Earth. Observations were made with the Nordic Optical Telescope (NOT) at La Roque de los Muchachos, La Palma, Canarias, Spain. They were conducted between 2011 May 09 and September 15 using the near-infrared Camera (NOTCam)3 on the NOT. NOTcam field of view is 4'x4' with a pixel scale of 0.234-arcsec/pixel designed to be used in the range from 0.8 to 2.5um in the bands J, H and K. (1 data file).

Integrated Solar-Panel Antenna Array for CubeSats

NASA Technical Reports Server (NTRS)

Baktur, Reyhan

2016-01-01

The goal of the Integrated Solar-Panel Antenna Array for CubeSats (ISAAC) project is to design and demonstrate an effective and efficien toptically transparent, high-gain, lightweight, conformal X-band antenna array that is integrated with the solar panels of a CubeSat. The targeted demonstration is for a Near Earth Network (NEN)radio at X-band, but the design can be easilyscaled to other network radios for higher frequencies. ISAAC is a less expensive and more flexible design for communication systemscompared to a deployed dish antenna or the existing integrated solar panel antenna design.

Concept design of an 80-dual polarization element cryogenic phased array camera for the Arecibo Radio Telescope

NASA Astrophysics Data System (ADS)

Cortes-Medellin, German; Parshley, Stephen; Campbell, Donald B.; Warnick, Karl F.; Jeffs, Brian D.; Ganesh, Rajagopalan

2016-08-01

This paper presents the current concept design for ALPACA (Advanced L-Band Phased Array Camera for Arecibo) an L-Band cryo-phased array instrument proposed for the 305 m radio telescope of Arecibo. It includes the cryogenically cooled front-end with 160 low noise amplifiers, a RF-over-fiber signal transport and a digital beam former with an instantaneous bandwidth of 312.5 MHz per channel. The camera will digitally form 40 simultaneous beams inside the available field of view of the Arecibo telescope optics, with an expected system temperature goal of 30 K.

rfpipe: Radio interferometric transient search pipeline

NASA Astrophysics Data System (ADS)

Law, Casey J.

2017-10-01

rfpipe supports Python-based analysis of radio interferometric data (especially from the Very Large Array) and searches for fast radio transients. This extends on the rtpipe library (ascl:1706.002) with new approaches to parallelization, acceleration, and more portable data products. rfpipe can run in standalone mode or be in a cluster environment.

Fast radio burst tied to distant dwarf galaxy (Image 2)

NSF Multimedia

2017-06-07

Radio telescope at Arecibo only localized the fast radio burst to the area inside the two circles in this image, but the Very Large Array was able to pinpoint it as a dwarf galaxy within the square (shown at intersection of cross hairs in enlarged box)

Adolescent relationship abuse and reproductive and sexual coercion among teens.

PubMed

Miller, Elizabeth; McCauley, Heather L

2013-10-01

Adolescent relationship abuse (ARA) involves a range of coercive and violent behaviours in romantic or consensual relationships. ARA is prevalent and is associated with multiple poor reproductive and sexual health outcomes, especially for adolescent girls. Recent studies and reviews of ARA research point to the prevalence of ARA, health consequences of ARA and the contribution of social and cultural norms to ARA perpetration, all of which can inform how to address ARA more effectively with adolescents. Emerging research on reproductive and sexual coercion among adolescents and technology-based abuse is directly relevant to the reproductive and sexual healthcare of adolescents. Current findings underscore the extent to which young, reproductive-aged women may particularly benefit from more effective methods to address ARA. In line with recent American Congress of Obstetricians and Gynecologists recommendations, clinicians should assess for and counsel their adolescent female patients about how ARA and reproductive and sexual coercion may influence adolescent girls' reproductive health. Recent evidence also highlights that ARA manifests in ways that may be less recognizable to clinicians, such as cyber dating abuse. Finally, ARA prevention and intervention efforts should continue to promote gender equity and address the social and cultural norms that shape adolescent girls' experiences of abuse.

Wide Field Radio Transient Surveys

NASA Astrophysics Data System (ADS)

Bower, Geoffrey

2011-04-01

The time domain of the radio wavelength sky has been only sparsely explored. Nevertheless, serendipitous discovery and results from limited surveys indicate that there is much to be found on timescales from nanoseconds to years and at wavelengths from meters to millimeters. These observations have revealed unexpected phenomena such as rotating radio transients and coherent pulses from brown dwarfs. Additionally, archival studies have revealed an unknown class of radio transients without radio, optical, or high-energy hosts. The new generation of centimeter-wave radio telescopes such as the Allen Telescope Array (ATA) will exploit wide fields of view and flexible digital signal processing to systematically explore radio transient parameter space, as well as lay the scientific and technical foundation for the Square Kilometer Array. Known unknowns that will be the target of future transient surveys include orphan gamma-ray burst afterglows, radio supernovae, tidally-disrupted stars, flare stars, and magnetars. While probing the variable sky, these surveys will also provide unprecedented information on the static radio sky. I will present results from three large ATA surveys (the Fly's Eye survey, the ATA Twenty CM Survey (ATATS), and the Pi GHz Survey (PiGSS)) and several small ATA transient searches. Finally, I will discuss the landscape and opportunities for future instruments at centimeter wavelengths.

Sensitivity of Pulsar Timing Arrays

NASA Astrophysics Data System (ADS)

Siemens, Xavier

2015-08-01

For the better part of the last decade, the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) has been using the Green Bank and Arecibo radio telescopes to monitor millisecond pulsars. NANOGrav, along with similar international collaborations, the European Pulsar Timing Array and the Parkes Pulsar Timing Array in Australia, form a consortium of consortia: the International Pulsar Timing Array (IPTA). The goal of the IPTA is to directly detect low-frequency gravitational waves which cause small changes to the times of arrival of radio pulses from millisecond pulsars. In this talk I will discuss the work of NANOGrav and the IPTA as well as our sensitivity to gravitational waves from astrophysical sources. I will show that a detection is possible by the end of the decade.

Revealing two radio-active galactic nuclei extremely near PSR J0437-4715

NASA Astrophysics Data System (ADS)

Li, Zhixuan; Yang, Jun; An, Tao; Paragi, Zsolt; Deller, Adam; Reynolds, Cormac; Hong, Xiaoyu; Wang, Jiancheng; Ding, Hao; Xia, Bo; Yan, Zhen; Guo, Li

2018-05-01

Newton's gravitational constant G may vary with time at an extremely low level. The time variability of G will affect the orbital motion of a millisecond pulsar in a binary system and cause a tiny difference between the orbital period-dependent measurement of the kinematic distance and the direct measurement of the annual parallax distance. PSR J0437-4715 is the nearest millisecond pulsar and the brightest at radio wavelengths. To explore the feasibility of achieving a parallax distance accuracy of one light-year, comparable to the recent timing result, with the technique of differential astrometry, we searched for compact radio sources quite close to PSR J0437-4715. Using existing data from the Very Large Array and the Australia Telescope Compact Array, we detected two sources with flat spectra, relatively stable flux densities of 0.9 and 1.0 mJy at 8.4 GHz and separations of 13 and 45 arcsec. With a network consisting of the Long Baseline Array and the Kunming 40-m radio telescope, we found that both sources have a point-like structure and a brightness temperature of ≥107 K. According to these radio inputs and the absence of counterparts in other bands, we argue that they are most likely the compact radio cores of extragalactic active galactic nuclei, rather than Galactic radio stars. The finding of these two radio active galactic nuclei will enable us to achieve a sub-pc distance accuracy with in-beam phase-referencing very-long-baseline interferometric observations and provide one of the most stringent constraints on the time variability of G in the near future.

The Giant Radio Array for Neutrino Detection

NASA Astrophysics Data System (ADS)

Kotera, K.; GRAND Collaboration

2017-12-01

The Giant Radio Array for Neutrino Detection (GRAND) project aims at detecting ultrahigh-energy neutrinos and cosmic rays with a ˜10^5 radio antenna array over 200'000 km^2 in mountainous regions in China, in order to solve the mystery of the origin of these two linked particles. Its strategy is to detect extensive air showers of the highest energies, above 10^{17} eV, that are triggered by the interaction of high-energy particles in the atmosphere or underground. In its first stages, GRAND will be competitive to detect the first cosmogenic neutrinos for favorable source scenarios. Ultimately, GRAND aims at reaching a sensitivity and angular resolution that should launch neutrino astronomy, and that will ensure the detection of these neutrinos, even in the most pessimistic cases. We present preliminary results of our simulations, plans for the ongoing, staged approach to the construction of GRAND, and the rich research program made possible by the design of GRAND.

Differences in the cancer burden among foreign-born and US-born Arab Americans living in metropolitan Detroit.

PubMed

Khan, Fatima; Ruterbusch, Julie J; Gomez, Scarlett L; Schwartz, Kendra

2013-11-01

Migrant studies often provide clues for cancer etiology. We estimated the cancer burden among Arab Americans (ArA) by immigrant status in the metropolitan Detroit area, home to one of the highest concentrations of ArA in USA. A validated name algorithm was used to identify ArA cancer cases diagnosed 1990-2009 in the Detroit SEER database. Recorded birthplace was supplemented with imputation of nativity using birthdate and social security number. Age-adjusted, gender-specific proportional incidence ratios and 95 % confidence intervals were calculated comparing all ArA, foreign-born ArA, and US-born ArA, to non-Hispanic Whites (NHW). Foreign-born ArA males had higher proportions of multiple myeloma, leukemia, kidney, liver, stomach, and bladder cancer than NHW, while bladder cancer and leukemia were higher among US-born ArA males. For ArA women, gall bladder and thyroid cancers were proportionally higher among both foreign- and US-born compared with NHW. Stomach cancer was proportionally higher only among foreign-born women. Cancer proportional incidence patterns among ArA show some similarity to other migrant groups, with higher proportional incidences of stomach and liver cancers among foreign-born than US-born. Other patterns, such as tobacco-related cancers among ArA men and gall bladder and thyroid cancers among ArA women, will require more investigation of genetic, epigenetic, and environmental factors.

The Essentiality of Arachidonic Acid in Infant Development

PubMed Central

Hadley, Kevin B.; Ryan, Alan S.; Forsyth, Stewart; Gautier, Sheila; Salem, Norman

2016-01-01

Arachidonic acid (ARA, 20:4n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by the biosynthesis from linoleic acid (LA, 18:2n-6). This review considers the essential role that ARA plays in infant development. ARA is always present in human milk at a relatively fixed level and is accumulated in tissues throughout the body where it serves several important functions. Without the provision of preformed ARA in human milk or infant formula the growing infant cannot maintain ARA levels from synthetic pathways alone that are sufficient to meet metabolic demand. During late infancy and early childhood the amount of dietary ARA provided by solid foods is low. ARA serves as a precursor to leukotrienes, prostaglandins, and thromboxanes, collectively known as eicosanoids which are important for immunity and immune response. There is strong evidence based on animal and human studies that ARA is critical for infant growth, brain development, and health. These studies also demonstrate the importance of balancing the amounts of ARA and DHA as too much DHA may suppress the benefits provided by ARA. Both ARA and DHA have been added to infant formulas and follow-on formulas for more than two decades. The amounts and ratios of ARA and DHA needed in infant formula are discussed based on an in depth review of the available scientific evidence. PMID:27077882

Multi-Beam Radio Frequency (RF) Aperture Arrays Using Multiplierless Approximate Fast Fourier Transform (FFT)

DTIC Science & Technology

2017-08-01

filtering, correlation and radio- astronomy . In this report approximate transforms that closely follow the DFT have been studied and found. The approximate...communications, data networks, sensor networks, cognitive radio, radar and beamforming, imaging, filtering, correlation and radio- astronomy . FFTs efficiently...public release; distribution is unlimited. 4.3 Digital Hardware and Design Architectures Collaboration for Astronomy Signal Processing and Electronics

Current Status of The Low Frequency All Sky Monitor

NASA Astrophysics Data System (ADS)

Dartez, Louis; Creighton, Teviet; Jenet, Fredrick; Dolch, Timothy; Boehler, Keith; Bres, Luis; Cole, Brent; Luo, Jing; Miller, Rossina; Murray, James; Reyes, Alex; Rivera, Jesse

2018-01-01

The Low Frequency All Sky Monitor (LoFASM) is a distributed array of cross-dipole antennas that are sensitive to radio frequencies from 10 to 88 MHz. LoFASM consists of antennas and front end electronics that were originally developed for the Long Wavelength Array by the U.S. Naval Research Lab, the University of New Mexico, Virginia Tech, and the Jet Propulsion Laboratory. LoFASM, funded by the U.S. Department of Defense, will initially consist of 4 stations, each consisting of 12 dual- polarization dipole antenna stands. The primary science goals of LoFASM will be the detection and study of low-frequency radio transients, a high priority science goal as deemed by the National Research Council’s ASTRO2010 decadal survey. The data acquisition system for the LoFASM antenna array uses Field Programmable Gate Array (FPGA) technology to implement a real time full Stokes spectrometer and data recorder. This poster presents an overview of the LoFASM Radio Telescope as well as the status of data analysis of initial commissioning observations.

Armenian Astronomical Society (ArAS) activities

NASA Astrophysics Data System (ADS)

Mickaelian, A. M.

2016-09-01

A review on the activities and achievements of Armenian Astronomical Society (ArAS) and Armenian astronomy in general during the last years is given. ArAS membership, ArAS electronic newsletters (ArASNews), ArAS webpage, Annual Meetings, Annual Prize for Young Astronomers (Yervant Terzian Prize) and other awards, international relations, presence in international organizations, local and international summer schools, science camps, astronomical Olympiads and other events, matters related to astronomical education, astronomical heritage, amateur astronomy, astronomy outreach and ArAS further projects are described and discussed.

Ara h 2 cross-linking catalyzed by MTGase decreases its allergenicity.

PubMed

Wu, Zhihua; Lian, Jun; Zhao, Ruifang; Li, Kun; Li, Xin; Yang, Anshu; Tong, Ping; Chen, Hongbing

2017-03-22

Peanuts, whose major allergen is Ara h 2, are included among the eight major food allergens. After reduction using dithiothreitol (DTT), cross-linking of Ara h 2 could be catalyzed by microbial transglutaminase (MTGase), a widely used enzyme in the food industry. In this study, Ara h 2 cross-linking was catalyzed by MTGase after it was reduced by DTT. Using mass spectrometry and PLINK software, five cross-linkers were identified, and five linear allergen epitopes were found to be involved in the reactions. The IgE binding capacity of cross-linked Ara h 2 was found to be significantly lower compared to that of native and reduced Ara h 2. After simulated gastric fluid (SGF) digestion, the digested products of the cross-linked Ara h 2, again, had a significantly lower IgE binding capacity compared to untreated and reduced Ara h 2. Furthermore, reduced and cross-linked Ara h 2 (RC-Ara h 2) induced lower sensitization in mice, indicating its lower allergenicity. Reduction and MTGase-catalyzed cross-linking are effective methods to decrease the allergenicity of Ara h 2. The reactions involved linear allergen epitopes destroying the material basis of the allergenicity, and this might develop a new direction for protein desensitization processes.

Aurora B inhibitor barasertib and cytarabine exert a greater-than-additive cytotoxicity in acute myeloid leukemia cells.

PubMed

Yamauchi, Takahiro; Uzui, Kanako; Shigemi, Hiroko; Negoro, Eiju; Yoshida, Akira; Ueda, Takanori

2013-07-01

Barasertib, an aurora B inhibitor, terminates cell division, introduces polyploidy, and consequently causes apoptosis. In the present study, we evaluated the effect of the combination of barasertib and cytarabine (ara-C), a key agent for leukemia chemotherapy, on leukemic cells in vitro. Human leukemia HL-60 cells and HL-60/ara-C20 cells, a 20-fold ara-C-resistant variant, were used. The 50% growth inhibitory concentrations of an active metabolite of barasertib, barasertib-hydroxyquinazoline-pyrazol-aniline (Barasertib-HQPA), and ara-C were 51 nM and 300 nM for HL-60 cells and 70 nM and 5300 nM for HL-60/ara-C20 cells, respectively. Barasertib-HQPA induced polyploidy with a subsequent induction of sub-G1 phase apoptosis, indicating the M-phase specific cytotoxicity. Cells treated with the S-phase specific ara-C accumulated in S phase and subsequently died through apoptosis. When HL-60 cells were treated with barasertib-HQPA and ara-C in combination, a greater-than-additive apoptosis was induced. This enhancement was obtained when the cells were treated with barasertib-HQPA prior to ara-C (37.9% sub-G1) or with both concurrently (31.2% sub-G1), but not with ara-C prior to barasertib-HQPA (17.8% sub-G1). The combination effects were similarly obtained in HL-60/ara-C20 cells with 19.7% sub-G1 for barasertib-HQPA→ara-C, 18.4% sub-G1 for both concurrently, and 13.8% sub-G1 for ara-C→barasertib-HQPA, and another leukemic U937 cells with 25.4% sub-G1 for barasertib-HQPA→ara-C, 28.2% sub-G1 for both concurrently, and 16.0% sub-G1 for ara-C→barasertib-HQPA. Barasertib-HQPA inhibited aurora B autophosphorylation and histone H3 phosphorylation in all the cell lines. Barasertib-HQPA did not inhibit DNA synthesis, allowing ara-C incorporation into DNA for its cytotoxicity. Thus, barasertib-HQPA and ara-C provided a greater-than-additive cytotoxicity in leukemic cells in vitro. © 2013 Japanese Cancer Association.

44. ARAIII Fuel oil tank ARA710. Camera facing west. Perimeter ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. ARA-III Fuel oil tank ARA-710. Camera facing west. Perimeter fence at left side of view. Gable-roofed building beyond tank on right is ARA-622. Gable-roofed building beyond tank on left is ARA-610. Ineel photo no. 3-16. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Full-Sky Maps of the VHF Radio Sky with the Owens Valley Radio Observatory Long Wavelength Array

NASA Astrophysics Data System (ADS)

Eastwood, Michael W.; Hallinan, Gregg

2018-05-01

21-cm cosmology is a powerful new probe of the intergalactic medium at redshifts 20 >~ z >~ 6 corresponding to the Cosmic Dawn and Epoch of Reionization. Current observations of the highly-redshifted 21-cm transition are limited by the dynamic range they can achieve against foreground sources of low-frequency (<200 MHz) of radio emission. We used the Owens Valley Radio Observatory Long Wavelength Array (OVRO-LWA) to generate a series of new modern high-fidelity sky maps that capture emission on angular scales ranging from tens of degrees to ~15 arcmin, and frequencies between 36 and 73 MHz. These sky maps were generated from the application of Tikhonov-regularized m-mode analysis imaging, which is a new interferometric imaging technique that is uniquely suited for low-frequency, wide-field, drift-scanning interferometers.

Air shower measurements with the LOPES radio antenna array

NASA Astrophysics Data System (ADS)

Lopes Collaboration; Haungs, A.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Auffenberg, J.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Kolotaev, Y.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.; LOPES Collaboration

2009-06-01

LOPES is set up at the location of the KASCADE-Grande extensive air shower experiment in Karlsruhe, Germany and aims to measure and investigate radio pulses from extensive air showers. Since radio waves suffer very little attenuation, radio measurements allow the detection of very distant or highly inclined showers. These waves can be recorded day and night, and provide a bolometric measure of the leptonic shower component. LOPES is designed as a digital radio interferometer using high bandwidths and fast data processing and profits from the reconstructed air shower observables of KASCADE-Grande. The LOPES antennas are absolutely amplitude calibrated allowing to reconstruct the electric field strength which can be compared with predictions from detailed Monte-Carlo simulations. We report about the analysis of correlations present in the radio signals measured by the LOPES 30 antenna array. Additionally, LOPES operates antennas of a different type (LOPESSTAR) which are optimized for an application at the Pierre Auger Observatory. Status, recent results of the data analysis and further perspectives of LOPES and the possible large scale application of this new detection technique are discussed.

Acoustic Location of Lightning Using Interferometric Techniques

NASA Astrophysics Data System (ADS)

Erives, H.; Arechiga, R. O.; Stock, M.; Lapierre, J. L.; Edens, H. E.; Stringer, A.; Rison, W.; Thomas, R. J.

2013-12-01

Acoustic arrays have been used to accurately locate thunder sources in lightning flashes. The acoustic arrays located around the Magdalena mountains of central New Mexico produce locations which compare quite well with source locations provided by the New Mexico Tech Lightning Mapping Array. These arrays utilize 3 outer microphones surrounding a 4th microphone located at the center, The location is computed by band-passing the signal to remove noise, and then computing the cross correlating the outer 3 microphones with respect the center reference microphone. While this method works very well, it works best on signals with high signal to noise ratios; weaker signals are not as well located. Therefore, methods are being explored to improve the location accuracy and detection efficiency of the acoustic location systems. The signal received by acoustic arrays is strikingly similar to th signal received by radio frequency interferometers. Both acoustic location systems and radio frequency interferometers make coherent measurements of a signal arriving at a number of closely spaced antennas. And both acoustic and interferometric systems then correlate these signals between pairs of receivers to determine the direction to the source of the received signal. The primary difference between the two systems is the velocity of propagation of the emission, which is much slower for sound. Therefore, the same frequency based techniques that have been used quite successfully with radio interferometers should be applicable to acoustic based measurements as well. The results presented here are comparisons between the location results obtained with current cross correlation method and techniques developed for radio frequency interferometers applied to acoustic signals. The data were obtained during the summer 2013 storm season using multiple arrays sensitive to both infrasonic frequency and audio frequency acoustic emissions from lightning. Preliminary results show that interferometric techniques have good potential for improving the lightning location accuracy and detection efficiency of acoustic arrays.

The Evolving Polarized Jet of Black Hole Candidate Swift J1745-26

NASA Technical Reports Server (NTRS)

Curran, P. A.; Coriat, M.; Miller-Jones, J. C. A.; Armstrong, R. P.; Edwards, P. G.; Sivakoff, G. R.; Woudt, P.; Altamirano, D.; Belloni, T. M.; Corbel, S.;

Subarray Processing for Projection-based RFI Mitigation in Radio Astronomical Interferometers

NASA Astrophysics Data System (ADS)

Burnett, Mitchell C.; Jeffs, Brian D.; Black, Richard A.; Warnick, Karl F.

2018-04-01

Radio Frequency Interference (RFI) is a major problem for observations in Radio Astronomy (RA). Adaptive spatial filtering techniques such as subspace projection are promising candidates for RFI mitigation; however, for radio interferometric imaging arrays, these have primarily been used in engineering demonstration experiments rather than mainstream scientific observations. This paper considers one reason that adoption of such algorithms is limited: RFI decorrelates across the interferometric array because of long baseline lengths. This occurs when the relative RFI time delay along a baseline is large compared to the frequency channel inverse bandwidth used in the processing chain. Maximum achievable excision of the RFI is limited by covariance matrix estimation error when identifying interference subspace parameters, and decorrelation of the RFI introduces errors that corrupt the subspace estimate, rendering subspace projection ineffective over the entire array. In this work, we present an algorithm that overcomes this challenge of decorrelation by applying subspace projection via subarray processing (SP-SAP). Each subarray is designed to have a set of elements with high mutual correlation in the interferer for better estimation of subspace parameters. In an RFI simulation scenario for the proposed ngVLA interferometric imaging array with 15 kHz channel bandwidth for correlator processing, we show that compared to the former approach of applying subspace projection on the full array, SP-SAP improves mitigation of the RFI on the order of 9 dB. An example of improved image synthesis and reduced RFI artifacts for a simulated image “phantom” using the SP-SAP algorithm is presented.

Hydrogen Epoch of Reinozation Array (HERA) Calibrated FFT Correlator Simulation

NASA Astrophysics Data System (ADS)

Salazar, Jeffrey David; Parsons, Aaron

2018-01-01

The Hydrogen Epoch of Reionization Array (HERA) project is an astronomical radio interferometer array with a redundant baseline configuration. Interferometer arrays are being used widely in radio astronomy because they have a variety of advantages over single antenna systems. For example, they produce images (visibilities) closely matching that of a large antenna (such as the Arecibo observatory), while both the hardware and maintenance costs are significantly lower. However, this method has some complications; one being the computational cost of correlating data from all of the antennas. A correlator is an electronic device that cross-correlates the data between the individual antennas; these are what radio astronomers call visibilities. HERA, being in its early stages, utilizes a traditional correlator system. The correlator cost scales as N2, where N is the number of antennas in the array. The purpose of a redundant baseline configuration array setup is for the use of a more efficient Fast Fourier Transform (FFT) correlator. FFT correlators scale as Nlog2N. The data acquired from this sort of setup, however, inherits geometric delay and uncalibrated antenna gains. This particular project simulates the process of calibrating signals from astronomical sources. Each signal “received” by an antenna in the simulation is given random antenna gain and geometric delay. The “linsolve” Python module was used to solve for the unknown variables in the simulation (complex gains and delays), which then gave a value for the true visibilities. This first version of the simulation only mimics a one dimensional redundant telescope array detecting a small amount of sources located in the volume above the antenna plane. Future versions, using GPUs, will handle a two dimensional redundant array of telescopes detecting a large amount of sources in the volume above the array.

Mpc-scale diffuse radio emission in two massive cool-core clusters of galaxies

NASA Astrophysics Data System (ADS)

Sommer, Martin W.; Basu, Kaustuv; Intema, Huib; Pacaud, Florian; Bonafede, Annalisa; Babul, Arif; Bertoldi, Frank

2017-04-01

Radio haloes are diffuse synchrotron sources on scales of ˜1 Mpc that are found in merging clusters of galaxies, and are believed to be powered by electrons re-accelerated by merger-driven turbulence. We present measurements of extended radio emission on similarly large scales in two clusters of galaxies hosting cool cores: Abell 2390 and Abell 2261. The analysis is based on interferometric imaging with the Karl G. Jansky Very Large Array, Very Large Array and Giant Metrewave Radio Telescope. We present detailed radio images of the targets, subtract the compact emission components and measure the spectral indices for the diffuse components. The radio emission in A2390 extends beyond a known sloshing-like brightness discontinuity, and has a very steep in-band spectral slope at 1.5 GHz that is similar to some known ultrasteep spectrum radio haloes. The diffuse signal in A2261 is more extended than in A2390 but has lower luminosity. X-ray morphological indicators, derived from XMM-Newton X-ray data, place these clusters in the category of relaxed or regular systems, although some asymmetric features that can indicate past minor mergers are seen in the X-ray brightness images. If these two Mpc-scale radio sources are categorized as giant radio haloes, they question the common assumption of radio haloes occurring exclusively in clusters undergoing violent merging activity, in addition to commonly used criteria for distinguishing between radio haloes and minihaloes.

DETECTION OF FAST RADIO TRANSIENTS WITH MULTIPLE STATIONS: A CASE STUDY USING THE VERY LONG BASELINE ARRAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, David R.; Wagstaff, Kiri L.; Majid, Walid A.

2011-07-10

Recent investigations reveal an important new class of transient radio phenomena that occur on submillisecond timescales. Often, transient surveys' data volumes are too large to archive exhaustively. Instead, an online automatic system must excise impulsive interference and detect candidate events in real time. This work presents a case study using data from multiple geographically distributed stations to perform simultaneous interference excision and transient detection. We present several algorithms that incorporate dedispersed data from multiple sites, and report experiments with a commensal real-time transient detection system on the Very Long Baseline Array. We test the system using observations of pulsar B0329+54.more » The multiple-station algorithms enhanced sensitivity for detection of individual pulses. These strategies could improve detection performance for a future generation of geographically distributed arrays such as the Australian Square Kilometre Array Pathfinder and the Square Kilometre Array.« less

Tracking and Navigation of Future NASA Spacecraft with the Square Kilometer Array

NASA Astrophysics Data System (ADS)

Resch, G. M.; Jones, D. L.; Connally, M. J.; Weinreb, S.; Preston, R. A.

2001-12-01

The international radio astronomy community is currently working on the design of an array of small radio antennas with a total collecting area of one square kilometer - more than a hundred times that of the largest existing (100-m) steerable antennas. An array of this size would provide obvious advantages for high data rate telemetry reception and for spacecraft navigation. Among these advantages are a two-orders-of-magnitude increase in sensitivity for telemetry downlink, flexible sub-arraying to track multiple spacecraft simultaneously, increased reliability through the use of large numbers of identical array elements, very accurate real-time angular spacecraft tracking, and a dramatic reduction in cost per unit area. NASA missions in many disciplines, including planetary science, would benefit from this increased ground-based tracking capability. The science return from planned missions could be increased, and opportunities for less expensive or completely new kinds of missions would be created.

On the radio properties of the intermediate-mass black hole candidate ESO 243-49 HLX-1

NASA Astrophysics Data System (ADS)

Cseh, D.; Webb, N. A.; Godet, O.; Barret, D.; Corbel, S.; Coriat, M.; Falcke, H.; Farrell, S. A.; Körding, E.; Lenc, E.; Wrobel, J. M.

2015-02-01

We present follow-up radio observations of ESO 243-49 HLX-1 from 2012 using the Australia Telescope Compact Array (ATCA) and the Karl G. Jansky Very Large Array (VLA). We report the detection of radio emission at the location of HLX-1 during its hard X-ray state using the ATCA. Assuming that the `Fundamental Plane' of accreting black holes is applicable, we provide an independent estimate of the black hole mass of M_{BH}≤ 2.8^{+7.5}_{-2.1} × 106 M⊙ at 90 per cent confidence. However, we argue that the detected radio emission is likely to be Doppler-boosted and our mass estimate is an upper limit. We discuss other possible origins of the radio emission such as being due to a radio nebula, star formation, or later interaction of the flares with the large-scale environment. None of these were found adequate. The VLA observations were carried out during the X-ray outburst. However, no new radio flare was detected, possibly due to a sparse time sampling. The deepest, combined VLA data suggest a variable radio source and we briefly discuss the properties of the previously detected flares and compare them with microquasars and active galactic nuclei.

CLOSE-UP LOOK AT A JET NEAR A BLACK HOLE

NASA Technical Reports Server (NTRS)

2002-01-01

[top left] - This radio image of the galaxy M87, taken with the Very Large Array (VLA) radio telescope in February 1989, shows giant bubble-like structures where radio emission is thought to be powered by the jets of subatomic particles coming from the the galaxy's central black hole. The false color corresponds to the intensity of the radio energy being emitted by the jet. M87 is located 50 million light-years away in the constellation Virgo. Credit: National Radio Astronomy Observatory/National Science Foundation [top right] - A visible light image of the giant elliptical galaxy M87, taken with NASA Hubble Space Telescope's Wide Field Planetary Camera 2 in February 1998, reveals a brilliant jet of high-speed electrons emitted from the nucleus (diagonal line across image). The jet is produced by a 3-billion-solar-mass black hole. Credit: NASA and John Biretta (STScI/JHU) [bottom] - A Very Long Baseline Array (VLBA) radio image of the region close to the black hole, where an extragalactic jet is formed into a narrow beam by magnetic fields. The false color corresponds to the intensity of the radio energy being emitted by the jet. The red region is about 1/10 light-year across. The image was taken in March 1999. Credit: National Radio Astronomy Observatory/Associated Universities, Inc.

Radio morphing - towards a full parametrisation of the radio signal from air showers

NASA Astrophysics Data System (ADS)

Zilles, A.; Charrier, D.; Kotera, K.; Le Coz, S.; Martineau-Huynh, O.; Medina, C.; Niess, V.; Tueros, M.; de Vries, K.

2017-12-01

Over the last decades, radio detection of air showers has been established as a detection technique for ultra-high-energy cosmic-rays impinging on the Earth's atmosphere with energies far beyond LHC energies. Today’s second-generation of digital radio-detection experiments, as e.g. AERA or LOFAR, are becoming competitive in comparison to already standard techniques e.g. fluorescence light detection. Thanks to a detailed understanding of the physics of the radio emission in extensive air showers, simulations of the radio signal are already successfully tested and applied in the reconstruction of cosmic rays. However the limits of the computational power resources are easily reached when it comes to computing electric fields at the numerous positions requested by large or dense antenna arrays. In the case of mountainous areas as e.g. for the GRAND array, where 3D shower simulations are necessary, the problem arises with even stronger acuity. Therefore we developed a full parametrisation of the emitted radio signal on the basis of generic shower simulations which will reduce the simulation time by orders of magnitudes. In this talk we will present this concept after a short introduction to the concept of the radio detection of air-shower induced by cosmic rays.

Differences in the Uptake of Ara h 3 from Raw and Roasted Peanut by Monocyte-Derived Dendritic Cells.

PubMed

Cabanillas, Beatriz; Maleki, Soheila J; Cheng, Hsiaopo; Novak, Natalija

2018-06-07

Roasting has been implicated in the increase of peanut allergenicity due to the chemical reactions that occur during the process. However, this increase is not fully understood, and little information is available regarding the role of roasted peanut allergens in the initial phase of allergy, where dendritic cells (DCs) play a key role. We sought to analyze differences in the internalization of Ara h 3 from raw and roasted peanut by immature monocyte-derived DCs (MDDCs) and the implication of the mannose receptor in the uptake. Ara h 3 was purified from raw and roasted peanut (Ara h 3-raw and Ara h 3-roas) and labeled with a fluorescent dye. The labeled allergens were added to MDDCs obtained from 7 donors and internalization was analyzed after 10, 30, and 120 min by flow cytometry. In parallel, mannan, which blocks the mannose receptor, was added 30 min before adding the labeled allergens. Results showed that the internalization of Ara h 3-roas by MDDCs was significantly increased at every time point. However, the increase in the internalization of Ara h 3-raw was only significant after 2 h of incubation. Ara h 3-roas had an enhanced capacity to be internalized by MDDCs in comparison with Ara h 3-raw at every time point. Blocking the mannose receptor decreased the internalization of Ara h 3-roas but not Ara h 3-raw. In conclusion, the internalization of Ara h 3-roas by the MDDCs is enhanced when compared to Ara h 3-raw, and the mannose receptor might be implicated in this enhancement. © 2018 S. Karger AG, Basel.

Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences.

PubMed

Namork, Ellen; Stensby, Berit A

2015-01-01

Peanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to investigate the sensitization pattern to the individual peanut allergens in a Norwegian population. Cases reported to the Norwegian Food Allergy Register with sera positive to peanut extract were analyzed for specific IgE (sIgE) to the recombinant peanut allergens Ara h 1, Ara h 2, Ara h 3, Ara h 8 and Ara h 9 and to birch pollen extract. Serum samples negative to the above allergens were analyzed for sIgE to Ara h 6, and sIgE to Pru p 3 in peach were analyzed in sera positive to the cross-reactive allergen Ara h 9. Highest frequency of sIgE to Ara h 2, often co-sensitized to Ara h 1 and 3, were found in the small children up to 6 years of age. From the age of 6 years, sensitization to Ara h 8 was predominant. The sIgE levels to the storage proteins Ara h 1, 2 and 3 were strongly correlated, as was the sIgE levels to Ara h 8 and birch pollen extract. A low sensitization rate of sIgE to Ara h 9 in young adults was observed, which sIgE levels were very strongly correlated to Pru p 3. The sensitization to peanut allergens in a Norwegian population shows a clear age dependent pattern. The results add to the previously published research on the sensitization patterns of peanut sensitized patients in different geographical areas.

A Cryogenic SiGe Low-noise Amplifier Optimized for Phased-array Feeds

NASA Astrophysics Data System (ADS)

Groves, Wavley M., III; Morgan, Matthew A.

2017-08-01

The growing number of phased-array feeds (PAF) being built for radio astronomy demonstrates an increasing need for low-noise amplifiers (LNA), which are designed for repeatability, low noise, and ease of manufacture. Specific design features that help to achieve these goals include the use of unpackaged transistors (for cryogenic operation); single-polarity biasing; straight plug-in radio frequency (RF) interfaces to facilitate installation and re-work; and the use of off-the-shelf components. The focal L-band array for the Green Bank Telescope (FLAG) is a cooperative effort by Brigham Young University and the National Radio Astronomy Observatory using warm dipole antennae and cryogenic Silicon Germanium Heterojunction Bipolar Transistor (SiGe HBT) LNAs. These LNAs have an in band gain average of 38 dB and 4.85 Kelvin average noise temperature. Although the FLAG instrument was the driving instrument behind this development, most of the key features of the design and the advantages they offer apply broadly to other array feeds, including independent-beam and phased, and for many antenna types such as horn, dipole, Vivaldi, connected-bowtie, etc. This paper focuses on the unique requirements array feeds have for low-noise amplifiers and how amplifier manufacturing can accommodate these needs.

Comparative analysis of effects of dietary arachidonic acid and EPA on growth, tissue fatty acid composition, antioxidant response and lipid metabolism in juvenile grass carp, Ctenopharyngodon idellus.

PubMed

Tian, Jing-Jing; Lei, Cai-Xia; Ji, Hong; Kaneko, Gen; Zhou, Ji-Shu; Yu, Hai-Bo; Li, Yang; Yu, Er-Meng; Xie, Jun

2017-09-01

Four isonitrogenous and isoenergetic purified diets containing free arachidonic acid (ARA) or EPA (control group), 0·30 % ARA, 0·30 % EPA and 0·30 % ARA+EPA (equivalent) were designed to feed juvenile grass carp (10·21 (sd 0·10) g) for 10 weeks. Only the EPA group presented better growth performance compared with the control group (P<0·05). Dietary ARA and EPA were incorporated into polar lipids more than non-polar lipids in hepatopancreas but not intraperitoneal fat (IPF) tissue. Fish fed ARA and EPA showed an increase of serum superoxide dismutase and catalase activities, and decrease of glutathione peroxidase activity and malondialdehyde contents (P<0·05). The hepatopancreatic TAG levels decreased both in ARA and EPA groups (P<0·05), accompanied by the decrease of lipoprotein lipase (LPL) activity in the ARA group (P<0·05). Fatty acid synthase (FAS), diacylglycerol O-acyltransferase and apoE gene expression in the hepatopancreas decreased in fish fed ARA and EPA, but only the ARA group exhibited increased mRNA level of adipose TAG lipase (ATGL) (P<0·05). Decreased IPF index and adipocyte sizes were found in the ARA group (P<0·05). Meanwhile, the ARA group showed decreased expression levels of adipogenic genes CCAAT enhancer-binding protein α, LPL and FAS, and increased levels of the lipid catabolic genes PPAR α, ATGL, hormone-sensitive lipase and carnitine palmitoyltransferase 1 (CPT-1) in IPF, whereas the EPA group only increased PPAR α and CPT-1 mRNA expression and showed less levels than the ARA group. Overall, dietary EPA is beneficial to the growth performance, whereas ARA is more potent in inducing lipolysis and inhibiting adipogenesis, especially in IPF. Meanwhile, dietary ARA and EPA showed the similar preference in esterification and the improvement in antioxidant response.

Remnant radio-loud AGN in the Herschel-ATLAS field

NASA Astrophysics Data System (ADS)

Mahatma, V. H.; Hardcastle, M. J.; Williams, W. L.; Brienza, M.; Brüggen, M.; Croston, J. H.; Gurkan, G.; Harwood, J. J.; Kunert-Bajraszewska, M.; Morganti, R.; Röttgering, H. J. A.; Shimwell, T. W.; Tasse, C.

2018-04-01

Only a small fraction of observed active galactic nuclei (AGN) display large-scale radio emission associated with jets, yet these radio-loud AGN have become increasingly important in models of galaxy evolution. In determining the dynamics and energetics of the radio sources over cosmic time, a key question concerns what happens when their jets switch off. The resulting `remnant' radio-loud AGN have been surprisingly evasive in past radio surveys, and therefore statistical information on the population of radio-loud AGN in their dying phase is limited. In this paper, with the recent developments of Low-Frequency Array (LOFAR) and the Very Large Array, we are able to provide a systematically selected sample of remnant radio-loud AGN in the Herschel-ATLAS field. Using a simple core-detection method, we constrain the upper limit on the fraction of remnants in our radio-loud AGN sample to 9 per cent, implying that the extended lobe emission fades rapidly once the core/jets turn off. We also find that our remnant sample has a wide range of spectral indices (-1.5≤slant α ^{1400}_{150}≤slant -0.5), confirming that the lobes of some remnants may possess flat spectra at low frequencies just as active sources do. We suggest that, even with the unprecedented sensitivity of LOFAR, our sample may still only contain the youngest of the remnant population.

A new strategy for array optimization applied to Brazilian Decimetric Array

NASA Astrophysics Data System (ADS)

Faria, C.; Stephany, S.; Sawant, H. S.

Radio interferometric arrays measure the Fourier transform of the sky brightness distribution in a finite set of points that are determined by the cross-correlation of different pairs of antennas of the array The sky brightness distribution is reconstructed by the inverse Fourier transform of the sampled visibilities The quality of the reconstructed images strongly depends on the array configuration since it determines the sampling function and therefore the points in the Fourier Plane This work proposes a new optimization strategy for the array configuration that is based on the entropy of the distribution of the samples points in the Fourier plane A stochastic optimizer the Ant Colony Optimization employs entropy of the point distribution in the Fourier plane to iteratively refine the candidate solutions The proposed strategy was developed for the Brazilian Decimetric Array BDA a radio interferometric array that is currently being developed for solar observations at the Brazilian Institute for Space Research Configurations results corresponding to the Fourier plane coverage synthesized beam and side lobes levels are shown for an optimized BDA configuration obtained with the proposed strategy and compared to the results for a standard T array configuration that was originally proposed

Clusters of Galaxies and the Cosmic Web with Square Kilometre Array

NASA Astrophysics Data System (ADS)

Kale, Ruta; Dwarakanath, K. S.; Vir Lal, Dharam; Bagchi, Joydeep; Paul, Surajit; Malu, Siddharth; Datta, Abhirup; Parekh, Viral; Sharma, Prateek; Pandey-Pommier, Mamta

2016-12-01

The intra-cluster and inter-galactic media that pervade the large scale structure of the Universe are known to be magnetized at sub-micro Gauss to micro Gauss levels and to contain cosmic rays. The acceleration of cosmic rays and their evolution along with that of magnetic fields in these media is still not well understood. Diffuse radio sources of synchrotron origin associated with the Intra-Cluster Medium (ICM) such as radio halos, relics and mini-halos are direct probes of the underlying mechanisms of cosmic ray acceleration. Observations with radio telescopes such as the Giant Metrewave Radio Telescope, the Very Large Array and the Westerbork Synthesis Radio Telescope have led to the discoveries of about 80 such sources and allowed detailed studies in the frequency range 0.15-1.4 GHz of a few. These studies have revealed scaling relations between the thermal and non-thermal properties of clusters and favour the role of shocks in the formation of radio relics and of turbulent re-acceleration in the formation of radio halos and mini-halos. The radio halos are known to occur in merging clusters and mini-halos are detected in about half of the cool-core clusters. Due to the limitations of current radio telescopes, low mass galaxy clusters and galaxy groups remain unexplored as they are expected to contain much weaker radio sources. Distinguishing between the primary and the secondary models of cosmic ray acceleration mechanisms requires spectral measurements over a wide range of radio frequencies and with high sensitivity. Simulations have also predicted weak diffuse radio sources associated with filaments connecting galaxy clusters. The Square Kilometre Array (SKA) is a next generation radio telescope that will operate in the frequency range of 0.05-20 GHz with unprecedented sensitivities and resolutions. The expected detection limits of SKA will reveal a few hundred to thousand new radio halos, relics and mini-halos providing the first large and comprehensive samples for their study. The wide frequency coverage along with sensitivity to extended structures will be able to constrain the cosmic ray acceleration mechanisms. The higher frequency (>5 GHz) observations will be able to use the Sunyaev-Zel'dovich effect to probe the ICM pressure in addition to tracers such as lobes of head-tail radio sources. The SKA also opens prospects to detect the `off-state' or the lowest level of radio emission from the ICM predicted by the hadronic models and the turbulent re-acceleration models.

Phased Antenna Array for Global Navigation Satellite System Signals

NASA Technical Reports Server (NTRS)

Turbiner, Dmitry (Inventor)

2015-01-01

Systems and methods for phased array antennas are described. Supports for phased array antennas can be constructed by 3D printing. The array elements and combiner network can be constructed by conducting wire. Different parameters of the antenna, like the gain and directivity, can be controlled by selection of the appropriate design, and by electrical steering. Phased array antennas may be used for radio occultation measurements.

Supplementation of arachidonic acid rich oil in European sea bass juveniles (Dicentrarchus labrax) diets: Effects on leucocytes and plasma fatty acid profiles, selected immune parameters and circulating prostaglandins levels.

PubMed

Torrecillas, S; Román, L; Rivero-Ramírez, F; Caballero, M J; Pascual, C; Robaina, L; Izquierdo, M S; Acosta, F; Montero, D

2017-05-01

The main objective of this study was to assess the effects of graded levels of dietary arachidonic acid (ARA), supplemented from alternative sources, on fatty acid composition of plasma and head kidney leucocytes of European sea bass (Dicentrarchus labrax). For that purpose, sea bass juveniles were fed four diets containing graded levels of ARA as follows: 0.5% (ARA0.5), 1% (ARA1), 2% (ARA2) and 4% (ARA4) during 60 days. At the end of the feeding trial fatty acid profiles of plasma and head kidney leucocytes were analyzed. Besides, plasma prostaglandins levels, head kidney leucocytes respiratory burst activity; peroxidase activity and phagocytic index were assayed. Reducing dietary ARA levels below 1% markedly reduced European sea bass growth performance. However, fish fed diet ARA0.5 tried to compensate this dietary ARA deficiency by a selective deposition of ARA on plasma and head kidney leucocytes, reaching similar levels to those fish fed diet ARA1 after 60 days of feeding. Nevertheless, head kidney phagocytic capacity was reduced as dietary ARA content in relation not only to variations on membrane composition but also to changes on fish basal prostaglandins levels. Results obtained demonstrated the importance to supply the necessary quantity n-6 LC-PUFA, and not only n-3 LC-PUFA levels, in European sea bass diets, in relation to not only growth performance but also immune system function. Copyright © 2017 Elsevier Ltd. All rights reserved.

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

PubMed

Schneider, Constanze; Oellerich, Thomas; Baldauf, Hanna-Mari; Schwarz, Sarah-Marie; Thomas, Dominique; Flick, Robert; Bohnenberger, Hanibal; Kaderali, Lars; Stegmann, Lena; Cremer, Anjali; Martin, Margarethe; Lohmeyer, Julian; Michaelis, Martin; Hornung, Veit; Schliemann, Christoph; Berdel, Wolfgang E; Hartmann, Wolfgang; Wardelmann, Eva; Comoglio, Federico; Hansmann, Martin-Leo; Yakunin, Alexander F; Geisslinger, Gerd; Ströbel, Philipp; Ferreirós, Nerea; Serve, Hubert; Keppler, Oliver T; Cinatl, Jindrich

2017-02-01

The nucleoside analog cytarabine (Ara-C) is an essential component of primary and salvage chemotherapy regimens for acute myeloid leukemia (AML). After cellular uptake, Ara-C is converted into its therapeutically active triphosphate metabolite, Ara-CTP, which exerts antileukemic effects, primarily by inhibiting DNA synthesis in proliferating cells. Currently, a substantial fraction of patients with AML fail to respond effectively to Ara-C therapy, and reliable biomarkers for predicting the therapeutic response to Ara-C are lacking. SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate. Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells. Mechanistically, dGTP-activated SAMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells. Loss of SAMHD1 activity-through genetic depletion, mutational inactivation of its triphosphohydrolase activity or proteasomal degradation using specialized, virus-like particles-potentiates the cytotoxicity of Ara-C in AML cells. In mouse models of retroviral AML transplantation, as well as in retrospective analyses of adult patients with AML, the response to Ara-C-containing therapy was inversely correlated with SAMHD1 expression. These results identify SAMHD1 as a potential biomarker for the stratification of patients with AML who might best respond to Ara-C-based therapy and as a target for treating Ara-C-refractory AML.

Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea

PubMed Central

Park, Kyung Hee; Son, Young Woong; Lee, Sang Chul; Jeong, Kyunguk; Sim, Da Woon; Park, Hye Jung; Lee, Sooyoung; Lee, Jae-Hyun

2016-01-01

Purpose Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. Methods Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis). Results After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries. Conclusions Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy. PMID:27582401

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats.

PubMed

Katakura, Masanori; Hashimoto, Michio; Inoue, Takayuki; Mamun, Abdullah Al; Tanabe, Yoko; Arita, Makoto; Shido, Osamu

2015-01-01

Arachidonic acid (ARA) metabolites produced by cyclo-oxygenase and lipoxygenase are important mediators maintaining physiological renal function. However, the effects of exogenous ARA on kidney function in vivo remain unknown. This study examined the effects of long-term oral ARA administration on normal renal function as well as inflammation and oxidative stress in aged rats. In addition, we measured levels of renal eicosanoids and docosanoids using liquid chromatography-tandem mass spectrometry. Control or ARA oil (240 mg/kg body weight/day) was orally administered to 21-month-old Wistar rats for 13 weeks. Levels of plasma creatinine, blood urea nitrogen, inflammatory and anti-inflammatory cytokines, reactive oxygen species, and lipid peroxidation were not significantly different between the two groups. The ARA concentration in the plasma, kidney, and liver increased in the ARA-administered group. In addition, levels of free-form ARA, prostaglandin E2, and 12- and 15-hydroxyeicosatetraenoic acid increased in the ARA-administered group, whereas renal concentration of docosahexaenoic acid and eicosapentaenoic acid decreased in the ARA-administered group. Levels of docosahexaenoic acid-derived protectin D1, eicosapentaenoic acid-derived 5-, and 18-hydroxyeicosapentaenoic acids, and resolvin E2 and E3 decreased in the ARA-administered group. Our results indicate that long-term ARA administration led to no serious adverse reactions under normal conditions and to a decrease in anti-inflammatory docosahexaenoic acid- and eicosapentaenoic acid-derived metabolites in the kidneys of aged rats. These results indicate that there is a possibility of ARA administration having a reducing anti-inflammatory effect on the kidney.

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats

PubMed Central

Katakura, Masanori; Hashimoto, Michio; Inoue, Takayuki; Mamun, Abdullah Al; Tanabe, Yoko; Arita, Makoto; Shido, Osamu

2015-01-01

Arachidonic acid (ARA) metabolites produced by cyclo-oxygenase and lipoxygenase are important mediators maintaining physiological renal function. However, the effects of exogenous ARA on kidney function in vivo remain unknown. This study examined the effects of long-term oral ARA administration on normal renal function as well as inflammation and oxidative stress in aged rats. In addition, we measured levels of renal eicosanoids and docosanoids using liquid chromatography–tandem mass spectrometry. Control or ARA oil (240 mg/kg body weight/day) was orally administered to 21-month-old Wistar rats for 13 weeks. Levels of plasma creatinine, blood urea nitrogen, inflammatory and anti-inflammatory cytokines, reactive oxygen species, and lipid peroxidation were not significantly different between the two groups. The ARA concentration in the plasma, kidney, and liver increased in the ARA-administered group. In addition, levels of free-form ARA, prostaglandin E2, and 12- and 15-hydroxyeicosatetraenoic acid increased in the ARA-administered group, whereas renal concentration of docosahexaenoic acid and eicosapentaenoic acid decreased in the ARA-administered group. Levels of docosahexaenoic acid-derived protectin D1, eicosapentaenoic acid-derived 5-, and 18-hydroxyeicosapentaenoic acids, and resolvin E2 and E3 decreased in the ARA-administered group. Our results indicate that long-term ARA administration led to no serious adverse reactions under normal conditions and to a decrease in anti-inflammatory docosahexaenoic acid- and eicosapentaenoic acid-derived metabolites in the kidneys of aged rats. These results indicate that there is a possibility of ARA administration having a reducing anti-inflammatory effect on the kidney. PMID:26485038

Constraints on submicrojansky radio number counts based on evolving VLA-COSMOS luminosity functions

NASA Astrophysics Data System (ADS)

Novak, M.; Smolčić, V.; Schinnerer, E.; Zamorani, G.; Delvecchio, I.; Bondi, M.; Delhaize, J.

2018-06-01

We present an investigation of radio luminosity functions (LFs) and number counts based on the Karl G. Jansky Very Large Array-COSMOS 3 GHz Large Project. The radio-selected sample of 7826 galaxies with robust optical/near-infrared counterparts with excellent photometric coverage allows us to construct the total radio LF since z 5.7. Using the Markov chain Monte Carlo algorithm, we fit the redshift dependent pure luminosity evolution model to the data and compare it with previously published VLA-COSMOS LFs obtained on individual populations of radio-selected star-forming galaxies and galaxies hosting active galactic nuclei classified on the basis of presence or absence of a radio excess with respect to the star-formation rates derived from the infrared emission. We find they are in excellent agreement, thus showing the reliability of the radio excess method in selecting these two galaxy populations at radio wavelengths. We study radio number counts down to submicrojansky levels drawn from different models of evolving LFs. We show that our evolving LFs are able to reproduce the observed radio sky brightness, even though we rely on extrapolations toward the faint end. Our results also imply that no new radio-emitting galaxy population is present below 1 μJy. Our work suggests that selecting galaxies with radio flux densities between 0.1 and 10 μJy will yield a star-forming galaxy in 90-95% of the cases with a high percentage of these galaxies existing around a redshift of z 2, thus providing useful constraints for planned surveys with the Square Kilometer Array and its precursors.

Detection of Traveling Ionospheric Disturbances by Medium Frequency Doppler Sounding Using AM Radio Transmissions

NASA Astrophysics Data System (ADS)

Chilcote, M. A.; Labelle, J. W.; Lind, F. D.; Coster, A. J.; Galkin, I. A.; Miller, E.; Weatherwax, A. T.

2013-12-01

Nighttime traveling ionosphere disturbances (TIDs) propagating in the lower F region of the ionosphere were detected from time variations in the Doppler shifts of commercial AM radio broadcast stations. Three separately deployed receivers, components of the Intercepted Signals for Ionospheric Science (ISIS) Array software radio instrumentation network, recorded signals from two radio stations during eleven nights in March-April, 2012. Combining these measurements established that variations in the frequencies of the received signals, with amplitudes up to a few tenths of a Hertz, resulted from Doppler shifts produced by the ionosphere. At times, TIDs were detected as large amplitude variations in the Doppler shift with approximately 40-minute period correlated across the array. For one study interval, 0000-0400 UT on April 13, 2012, simultaneous GPS-TEC, digisonde, and superDARN coherent backscatter radar measurements confirmed the detection of TIDs with the same period. Detection of the AM signals at widely spaced receivers allowed the phase velocity and wavelength of the TIDs to be inferred, with some limitations due to differing reflection heights for the different frequencies. These measurements will be compared to phase velocities and wavelengths determined from combining an array of GPS receivers; discrepancies due to the altitude sensitivity of the techniques or other effects will be discussed. These results demonstrate that AM radio signals can be used for detection of nighttime TIDs.

Spectral ageing in the era of big data: integrated versus resolved models

NASA Astrophysics Data System (ADS)

Harwood, Jeremy J.

2017-04-01

Continuous injection models of spectral ageing have long been used to determine the age of radio galaxies from their integrated spectrum; however, many questions about their reliability remain unanswered. With various large area surveys imminent (e.g. LOw Frequency ARray, MeerKAT, Murchison Widefield Array) and planning for the next generation of radio interferometers are well underway (e.g. next generation VLA, Square Kilometre Array), investigations of radio galaxy physics are set to shift away from studies of individual sources to the population as a whole. Determining if and how integrated models of spectral ageing can be applied in the era of big data is therefore crucial. In this paper, I compare classical integrated models of spectral ageing to recent well-resolved studies that use modern analysis techniques on small spatial scales to determine their robustness and validity as a source selection method. I find that integrated models are unable to recover key parameters and, even when known a priori, provide a poor, frequency-dependent description of a source's spectrum. I show a disparity of up to a factor of 6 in age between the integrated and resolved methods but suggest, even with these inconsistencies, such models still provide a potential method of candidate selection in the search for remnant radio galaxies and in providing a cleaner selection of high redshift radio galaxies in z - α selected samples.

LOFAR tied-array imaging and spectroscopy of solar S bursts

NASA Astrophysics Data System (ADS)

Morosan, D. E.; Gallagher, P. T.; Zucca, P.; O'Flannagain, A.; Fallows, R.; Reid, H.; Magdalenić, J.; Mann, G.; Bisi, M. M.; Kerdraon, A.; Konovalenko, A. A.; MacKinnon, A. L.; Rucker, H. O.; Thidé, B.; Vocks, C.; Alexov, A.; Anderson, J.; Asgekar, A.; Avruch, I. M.; Bentum, M. J.; Bernardi, G.; Bonafede, A.; Breitling, F.; Broderick, J. W.; Brouw, W. N.; Butcher, H. R.; Ciardi, B.; de Geus, E.; Eislöffel, J.; Falcke, H.; Frieswijk, W.; Garrett, M. A.; Grießmeier, J.; Gunst, A. W.; Hessels, J. W. T.; Hoeft, M.; Karastergiou, A.; Kondratiev, V. I.; Kuper, G.; van Leeuwen, J.; McKay-Bukowski, D.; McKean, J. P.; Munk, H.; Orru, E.; Paas, H.; Pizzo, R.; Polatidis, A. G.; Scaife, A. M. M.; Sluman, J.; Tasse, C.; Toribio, M. C.; Vermeulen, R.; Zarka, P.

2015-08-01

Context. The Sun is an active source of radio emission that is often associated with energetic phenomena ranging from nanoflares to coronal mass ejections (CMEs). At low radio frequencies (<100 MHz), numerous millisecond duration radio bursts have been reported, such as radio spikes or solar S bursts (where S stands for short). To date, these have neither been studied extensively nor imaged because of the instrumental limitations of previous radio telescopes. Aims: Here, LOw Frequency ARray (LOFAR) observations were used to study the spectral and spatial characteristics of a multitude of S bursts, as well as their origin and possible emission mechanisms. Methods: We used 170 simultaneous tied-array beams for spectroscopy and imaging of S bursts. Since S bursts have short timescales and fine frequency structures, high cadence (~50 ms) tied-array images were used instead of standard interferometric imaging, that is currently limited to one image per second. Results: On 9 July 2013, over 3000 S bursts were observed over a time period of ~8 h. S bursts were found to appear as groups of short-lived (<1 s) and narrow-bandwidth (~2.5 MHz) features, the majority drifting at ~3.5 MHz s-1 and a wide range of circular polarisation degrees (2-8 times more polarised than the accompanying Type III bursts). Extrapolation of the photospheric magnetic field using the potential field source surface (PFSS) model suggests that S bursts are associated with a trans-equatorial loop system that connects an active region in the southern hemisphere to a bipolar region of plage in the northern hemisphere. Conclusions: We have identified polarised, short-lived solar radio bursts that have never been imaged before. They are observed at a height and frequency range where plasma emission is the dominant emission mechanism, however, they possess some of the characteristics of electron-cyclotron maser emission. A movie associated to Fig. 3 is available in electronic form at http://www.aanda.org

Armenian Astronomical Society Annual Activities in 2014

NASA Astrophysics Data System (ADS)

Mickaelian, A. M.

2015-07-01

A report is given on the achievements of the Armenian astronomy during the last year and on the present activities of the Armenian Astronomical Society (ArAS). ArAS membership, ArAS electronic newsletters (ArASNews), ArAS webpage, annual meetings, Annual Prize for Young Astronomers (Yervant Terzian Prize) and other awards, international relations, presence in international organizations, summer schools, astronomical Olympiads and other events, matters related to astronomical education, astronomical heritage, astronomy outreach and ArAS further projects are discussed. The present meeting, BAO Science Camp, ArAS School lectures are among 2014 events as well.

47 CFR 15.615 - General administrative requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

47 CFR 15.615 - General administrative requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

47 CFR 15.615 - General administrative requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

47 CFR 15.615 - General administrative requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

47 CFR 15.615 - General administrative requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

The future of Canada's radio astronomy

NASA Astrophysics Data System (ADS)

Gaensler, Bryan M.

2017-11-01

Through involvement in CHIME, ALMA, the Jansky VLA and the Murchison Widefield Array, Canada is well placed in current radio astronomy facilities and the future looks even brighter, with strategic interest in the SKA and the Next Generation VLA.

New Antennas and Methods for the Low Frequency Stellar and Planetary Radio Astronomy

NASA Astrophysics Data System (ADS)

Konovalenko, A. A.; Falkovich, I. S.; Rucker, H. O.; Lecacheux, A.; Zarka, Ph.; Koliadin, V. L.; Zakharenko, V. V.; Stanislavsky, A. A.; Melnik, V. N.; Litvinenko, G. V.; Gridin, A. A.; Bubnov, I. N.; Kalinichenko, N. N.; Reznik, A. P.; Sidorchuk, M. A.; Stepkin, S. V.; Mukha, D. V.; Nikolajenko, V. S.; Karlsson, R.; Thide, B.

According to the special Program of the National Academy of Sciences of Ukraine, creation of the new giant Ukrainian radio telescope (GURT) was started a few years ago on the UTR-2 radio telescope observatory. The main goal is to reach maximum band at the lowest frequencies (10-70 MHz), effective area (step-by-step up to 100,000 sq.m), and high interference immunity for resolving many astrophysical tasks when the sensitivity is less limited by the confusion effects. These tasks include stellar radio astronomy (the Sun, solar wind, flare stars, pulsars, transients) and planetary one (Jupiter, planetary lightnings, Earth ionosphere, the Moon, exoplanets). This array should be complementary to the LOFAR, E-LOFAR systems. The first stages of the GURT (6 x 25 cross dipole active elements) and broad-band digital registration of the impulsive and sporadic events were tested in comparison with the existing largest decameter array UTR-2.

N-arachidonoyl--serine is neuroprotective after traumatic brain injury by reducing apoptosis

PubMed Central

Cohen-Yeshurun, Ayelet; Trembovler, Victoria; Alexandrovich, Alexander; Ryberg, Erik; Greasley, Peter J; Mechoulam, Raphael; Shohami, Esther; Leker, Ronen R

2011-01-01

N-arachidonoyl--serine (AraS) is a brain component structurally related to the endocannabinoid family. We investigated the neuroprotective effects of AraS following closed head injury induced by weight drop onto the exposed fronto-parietal skull and the mechanisms involved. A single injection of AraS following injury led to a significant improvement in functional outcome, and to reduced edema and lesion volume compared with vehicle. Specific antagonists to CB2 receptors, transient receptor potential vanilloid 1 (TRPV1) or large conductance calcium-activated potassium (BK) channels reversed these effects. Specific binding assays did not indicate binding of AraS to the GPR55 cannabinoid receptor. N-arachidonoyl--serine blocked the attenuation in phosphorylated extracellular-signal-regulated kinase 1/2 (ERK) levels and led to an increase in pAkt in both the ipsilateral and contralateral cortices. Increased levels of the prosurvival factor Bcl-xL were evident 24 hours after injury in AraS-treated mice, followed by a 30% reduction in caspase-3 activity, measured 3 days after injury. Treatment with a CB2 antagonist, but not with a CB1 antagonist, reversed this effect. Our results suggest that administration of AraS leads to neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways. These protective effects are related mostly to indirect signaling via the CB2R and TRPV1 channels but not through CB1 or GPR55 receptors. PMID:21505478

N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis.

PubMed

Cohen-Yeshurun, Ayelet; Trembovler, Victoria; Alexandrovich, Alexander; Ryberg, Erik; Greasley, Peter J; Mechoulam, Raphael; Shohami, Esther; Leker, Ronen R

2011-08-01

N-arachidonoyl-L-serine (AraS) is a brain component structurally related to the endocannabinoid family. We investigated the neuroprotective effects of AraS following closed head injury induced by weight drop onto the exposed fronto-parietal skull and the mechanisms involved. A single injection of AraS following injury led to a significant improvement in functional outcome, and to reduced edema and lesion volume compared with vehicle. Specific antagonists to CB2 receptors, transient receptor potential vanilloid 1 (TRPV1) or large conductance calcium-activated potassium (BK) channels reversed these effects. Specific binding assays did not indicate binding of AraS to the GPR55 cannabinoid receptor. N-arachidonoyl-L-serine blocked the attenuation in phosphorylated extracellular-signal-regulated kinase 1/2 (ERK) levels and led to an increase in pAkt in both the ipsilateral and contralateral cortices. Increased levels of the prosurvival factor Bcl-xL were evident 24 hours after injury in AraS-treated mice, followed by a 30% reduction in caspase-3 activity, measured 3 days after injury. Treatment with a CB2 antagonist, but not with a CB1 antagonist, reversed this effect. Our results suggest that administration of AraS leads to neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways. These protective effects are related mostly to indirect signaling via the CB2R and TRPV1 channels but not through CB1 or GPR55 receptors.

A Generic and Efficient E-field Parallel Imaging Correlator for Next-Generation Radio Telescopes

NASA Astrophysics Data System (ADS)

Thyagarajan, Nithyanandan; Beardsley, Adam P.; Bowman, Judd D.; Morales, Miguel F.

2017-05-01

Modern radio telescopes are favouring densely packed array layouts with large numbers of antennas (NA ≳ 1000). Since the complexity of traditional correlators scales as O(N_A^2), there will be a steep cost for realizing the full imaging potential of these powerful instruments. Through our generic and efficient E-field Parallel Imaging Correlator (epic), we present the first software demonstration of a generalized direct imaging algorithm, namely the Modular Optimal Frequency Fourier imager. Not only does it bring down the cost for dense layouts to O(N_A log _2N_A) but can also image from irregular layouts and heterogeneous arrays of antennas. epic is highly modular, parallelizable, implemented in object-oriented python, and publicly available. We have verified the images produced to be equivalent to those from traditional techniques to within a precision set by gridding coarseness. We have also validated our implementation on data observed with the Long Wavelength Array (LWA1). We provide a detailed framework for imaging with heterogeneous arrays and show that epic robustly estimates the input sky model for such arrays. Antenna layouts with dense filling factors consisting of a large number of antennas such as LWA, the Square Kilometre Array, Hydrogen Epoch of Reionization Array, and Canadian Hydrogen Intensity Mapping Experiment will gain significant computational advantage by deploying an optimized version of epic. The algorithm is a strong candidate for instruments targeting transient searches of fast radio bursts as well as planetary and exoplanetary phenomena due to the availability of high-speed calibrated time-domain images and low output bandwidth relative to visibility-based systems.

LOFAR discovery of an ultra-steep radio halo and giant head-tail radio galaxy in Abell 1132

NASA Astrophysics Data System (ADS)

Wilber, A.; Brüggen, M.; Bonafede, A.; Savini, F.; Shimwell, T.; van Weeren, R. J.; Rafferty, D.; Mechev, A. P.; Intema, H.; Andrade-Santos, F.; Clarke, A. O.; Mahony, E. K.; Morganti, R.; Prandoni, I.; Brunetti, G.; Röttgering, H.; Mandal, S.; de Gasperin, F.; Hoeft, M.

2018-01-01

Low-Frequency Array (LOFAR) observations at 144 MHz have revealed large-scale radio sources in the unrelaxed galaxy cluster Abell 1132. The cluster hosts diffuse radio emission on scales of ∼650 kpc near the cluster centre and a head-tail (HT) radio galaxy, extending up to 1 Mpc, south of the cluster centre. The central diffuse radio emission is not seen in NRAO VLA FIRST Survey, Westerbork Northern Sky Survey, nor in C & D array VLA observations at 1.4 GHz, but is detected in our follow-up Giant Meterwave Radio Telescope (GMRT) observations at 325 MHz. Using LOFAR and GMRT data, we determine the spectral index of the central diffuse emission to be α = -1.75 ± 0.19 (S ∝ να). We classify this emission as an ultra-steep spectrum radio halo and discuss the possible implications for the physical origin of radio haloes. The HT radio galaxy shows narrow, collimated emission extending up to 1 Mpc and another 300 kpc of more diffuse, disturbed emission, giving a full projected linear size of 1.3 Mpc - classifying it as a giant radio galaxy (GRG) and making it the longest HT found to date. The head of the GRG coincides with an elliptical galaxy (SDSS J105851.01+564308.5) belonging to Abell 1132. In our LOFAR image, there appears to be a connection between the radio halo and the GRG. The turbulence that may have produced the halo may have also affected the tail of the GRG. In turn, the GRG may have provided seed electrons for the radio halo.

V694 Mon (MWC 560) spectroscopy requested

NASA Astrophysics Data System (ADS)

Waagen, Elizabeth O.

2017-05-01

The observing campaign from 2016 on V694 Mon (MWC 560) (AAVSO Alert Notice 538) has been continued, but with different requirements. Photometry is no longer specifically requested on a regular basis (although ongoing observations that do not interfere with other obligations are welcome). Spectroscopy on a cadence of a week or two is requested to monitor changes in the disk outflow. Investigator Adrian Lucy writes: "Adrian Lucy and Dr. Jeno Sokoloski (Columbia University) have requested spectroscopic monitoring of the broad-absorption-line symbiotic star V694 Mon (MWC 560), as a follow-up to coordinated multi-wavelength observations obtained during its recent outburst (ATel #8653, #8832, #8957; #10281). This system is a perfect place in which to study the relationship between an accretion disk and disk winds/jets, and a high-value target for which even low-resolution spectra can be extraordinarily useful...Optical brightening in MWC 560 tends to predict higher-velocity absorption, but sometimes jumps in absorption velocity also appear during optical quiescence (e.g., Iijima 2001, ASPCS, 242, 187). If such a velocity jump occurs during photometric quiescence, it may prompt radio observations to confirm and test the proposed outflow origin for recently-discovered flat-spectrum radio emission (Lucy et al. ATel #10281)...Furthermore, volunteer spectroscopic monitoring of this system has proved useful in unpredictable ways. For example, 'amateur' spectra obtained by Somogyi Péter in 2015 December demonstrated that the velocity of absorption was very low only a month before an optical outburst peak prompted absorption troughs up to 3000 km/s, which constrains very well the timing of the changes to the outflow to a degree that would not have been otherwise possible. Any resolution can be useful. A wavelength range that can accommodate a blueshift of at least 140 angstroms (6000 km/s) from the rest wavelengths of H-alpha at 6562 angstroms and/or H-beta at 4861 angstroms is ideal, though spectra with a smaller range can still be useful. Photometry could potentially still be useful, but will be supplementary to medium-cadence photometry being collected by the ANS collaboration." "Spectroscopy may be uploaded to the ARAS database (http://www.astrosurf.com/aras/Aras_DataBase/DataBase.htm), or sent to Adrian and Jeno directly at . Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Photometry should be submitted to the AAVSO International Database. See full Special Notice for more details.

The Giant Radio Array for Neutrino Detection

NASA Astrophysics Data System (ADS)

Martineau-Huynh, Olivier; Bustamante, Mauricio; Carvalho, Washington; Charrier, Didier; De Jong, Sijbrand; de Vries, Krijn D.; Fang, Ke; Feng, Zhaoyang; Finley, Chad; Gou, Quanbu; Gu, Junhua; Hu, Hongbo; Kotera, Kumiko; Le Coz, Sandra; Medina, Clementina; Murase, Kohta; Niess, Valentin; Oikonomou, Foteini; Timmermans, Charles; Wang, Zhen; Wu, Xiangping; Zhang, Yi

2017-03-01

The Giant Radio Array for Neutrino Detection (GRAND) is a planned array of 2·105 radio antennas deployed over 200 000 km2 in a mountainous site. It aims primarly at detecting high-energy neutrinos via the observation of extensive air showers induced by the decay in the atmosphere of taus produced by the interaction of cosmic neutrinos under the Earth surface. GRAND aims at reaching a neutrino sensitivity of 5 · 10-11 E-2 GeV-1 cm-2 s-1 sr-1 above 3 · 1016 eV. This ensures the detection of cosmogenic neutrinos in the most pessimistic source models, and 50 events per year are expected for the standard models. The instrument will also detect UHECRs and possibly FRBs. Here we show how our preliminary design should enable us to reach our sensitivity goals, and discuss the steps to be taken to achieve GRAND, while the compelling science case for GRAND is discussed in more details in [1].

The history of early low frequency radio astronomy in Australia. 9: the University of Tasmania's Llanherne (Hobart Airport) Field Station during the 1960s-1980s

NASA Astrophysics Data System (ADS)

George, Martin; Orchiston, Wayne; Wielebinski, Richard

2018-04-01

Beginning in the early 1960s, the University of Tasmania became very involved in low frequency radio astronomical studies, which was to continue into the 1980s. Although important low frequency arrays were set up at Penna and Richmond, the main location for this activity by the University was in the vicinity of Hobart Airport, known as Llanherne. This paper describes the work performed there at frequencies of 30 MHz and below, mainly for studying radio emission from Jupiter and the Galaxy. The largest of the installations was the Llanherne Low Frequency Array, a 640 × 640 m antenna array adjacent to Holyman Avenue; it was well known to the public because of its high visibility to airport patrons. Other installations were set up closer to the airport runway. Various researchers, including Graeme Ellis, Hilary Cane and others, made observations at Llanherne.

Analysis of inclined showers measured with LOPES

NASA Astrophysics Data System (ADS)

Lopes Collaboration; Saftoiu, A.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Auffenberg, J.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Kolotaev, Y.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.; LOPES Collaboration

2009-06-01

In the present study, we analyze the radio signal from inclined air showers recorded by LOPES-30 in coincidence with KASCADE-Grande. LOPES-30 consists of 30 East-West oriented digital antennas, which are amplitude calibrated by an external source. Radio emission from air showers is considered a geomagnetic effect. Inclined events provide a larger range of values for geomagnetic angle (angle between shower axis and geomagnetic field direction) than vertical showers and thus more information on the emission processes can be gathered. In order to have the geometry of the air shower we use the reconstruction provided by the KASCADE-Grande particle detectors array. Analyzing events observed by both LOPES and the extended part of the KASCADE array, Grande, gives the possibility to test in particular the capability and efficiency of radio detection of more distant events. The results are compared with a previous analysis of inclined events recorded by the initial 10 antenna set-up, LOPES-10, in coincidence with the Grande array.

Blind calibration of radio interferometric arrays using sparsity constraints and its implications for self-calibration

NASA Astrophysics Data System (ADS)

Chiarucci, Simone; Wijnholds, Stefan J.

2018-02-01

Blind calibration, i.e. calibration without a priori knowledge of the source model, is robust to the presence of unknown sources such as transient phenomena or (low-power) broad-band radio frequency interference that escaped detection. In this paper, we present a novel method for blind calibration of a radio interferometric array assuming that the observed field only contains a small number of discrete point sources. We show the huge computational advantage over previous blind calibration methods and we assess its statistical efficiency and robustness to noise and the quality of the initial estimate. We demonstrate the method on actual data from a Low-Frequency Array low-band antenna station showing that our blind calibration is able to recover the same gain solutions as the regular calibration approach, as expected from theory and simulations. We also discuss the implications of our findings for the robustness of regular self-calibration to poor starting models.

The proposed NRAO millimeter array and its use for solar studies

NASA Technical Reports Server (NTRS)

Kundu, Mukul R.

1986-01-01

A brief summary is given of the proposed National Radio Astronomy Observatory (NRAO) Millimeter Array discussed at a workshop held in Green Bank, W. Va., September 30 to October 2, 1985. A brief description of the solar studies that can be made with such an array is provided.

Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: a double-blind placebo-controlled study.

PubMed

Kukkonen, A K; Pelkonen, A S; Mäkinen-Kiljunen, S; Voutilainen, H; Mäkelä, M J

2015-10-01

Component-resolved diagnostics offers a modern tool in peanut allergy, but studies applying consistently double-blind placebo-controlled challenges are lacking. We aimed to optimize diagnostics for moderate-to-severe peanut allergy in a birch-endemic region and to create an oral-peanut challenge with its allergen activity characterized. We performed double-blind placebo-controlled peanut challenges for a referred sample of 6- to 18-year-olds with peanut sensitization or a high suspicion of peanut allergy, including anaphylaxis. We measured specific IgE (sIgE) to Ara h 1, 2, 3, 6, 8, and 9. Testing of allergen activity of the challenge products was by IgE microarray inhibition. Of the 102 patients, 69 were challenge positive: 25 (36%) had severe, 36 (52%) moderate, and 8 (12%) mild symptoms; 38 (37%) received adrenalin. SIgE to Ara h 6 AUC 0.98 (95%CI, 0.96-1.00) was the best marker of moderate-to-severe allergy. When sIgE to Ara h 2 and Ara h 6 was measured together, all (100%) severe reactions at low doses were successfully diagnosable. SIgE to Ara h 8 had no diagnostic value, AUC 0.42 (95%CI, 0.30-0.52). Both nonroasted and roasted peanut inhibited 100% of IgE binding to Ara h 1, 2, 3, and 6. Nonroasted peanut inhibited 87% of IgE binding to Ara h 8, roasted inhibited 30%. The products lacked Ara h 9 activity. Co-sensitization to Ara h 2 and Ara h 6 was associated with severe reactions distinguishing severe allergy from mild symptoms. SIgE to Ara h 8 added no diagnostic value. Component-resolved diagnostics reduce the need for oral challenges in peanut allergy. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Docosahexaenoic acid (DHA) and arachidonic acid (ARA) balance in developmental outcomes.

PubMed

Colombo, John; Jill Shaddy, D; Kerling, Elizabeth H; Gustafson, Kathleen M; Carlson, Susan E

2017-06-01

The DHA Intake and Measurement of Neural Development (DIAMOND) trial represents one of only a few studies of the long-term dose-response effects of LCPUFA-supplemented formula feeding during infancy. The trial contrasted the effects of four formulations: 0.00% docosahexaenoic acid (DHA)/0.00% arachidonic acid (ARA), 0.32% DHA/0.64% ARA, 0.64% DHA/0.64% ARA, and 0.96% DHA/0.64% ARA against a control condition (0.00% DHA/0.00% ARA). The results of this trial have been published elsewhere, and show improved cognitive outcomes for infants fed supplemented formulas, but a common finding among many of the outcomes show a reduction of benefit for the highest DHA dose (i.e., 0.96%DHA/0.64% ARA, that is, a DHA: ARA ratio 1.5:1.0). The current paper gathers and summarizes the evidence for the reduction of benefit at this dose, and in an attempt to account for this reduced benefit, presents for the first time data from infants' red blood cell (RBC) assays taken at 4 and 12 months of age. Those assays indicate that blood DHA levels generally rose with increased DHA supplementation, although those levels tended to plateau as the DHA-supplemented level exceeded 0.64%. Perhaps more importantly, ARA levels showed a strong inverted-U function in response to increased DHA supplementation; indeed, infants assigned to the formula with the highest dose of DHA (and highest DHA/ARA ratio) showed a reduction in blood ARA relative to more intermediate DHA doses. This finding raises the possibility that reduced ARA may be responsible for the reduction in benefit on cognitive outcomes seen at this dose. The findings implicate the DHA/ARA balance as an important variable in the contribution of LCPUFAs to cognitive and behavioral development in infancy. Copyright © 2017 Elsevier Ltd. All rights reserved.

RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia.

PubMed

Abraham, Ajay; Varatharajan, Savitha; Karathedath, Sreeja; Philip, Chepsy; Lakshmi, Kavitha M; Jayavelu, Ashok Kumar; Mohanan, Ezhilpavai; Janet, Nancy Beryl; Srivastava, Vivi M; Shaji, Ramachandran V; Zhang, Wei; Abraham, Aby; Viswabandya, Auro; George, Biju; Chandy, Mammen; Srivastava, Alok; Mathews, Vikram; Balasubramanian, Poonkuzhali

2015-07-01

Variation in terms of outcome and toxic side effects of treatment exists among acute myeloid leukemia (AML) patients on chemotherapy with cytarabine (Ara-C) and daunorubicin (Dnr). Candidate Ara-C metabolizing gene expression in primary AML cells is proposed to account for this variation. Ex vivo Ara-C sensitivity was determined in primary AML samples using MTT assay. mRNA expression of candidate Ara-C metabolizing genes were evaluated by RQPCR analysis. Global gene expression profiling was carried out for identifying differentially expressed genes between exvivo Ara-C sensitive and resistant samples. Wide interindividual variations in ex vivo Ara-C cytotoxicity were observed among samples from patients with AML and were stratified into sensitive, intermediately sensitive and resistant, based on IC50 values obtained by MTT assay. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA) was significantly lower in ex vivo Ara-C sensitive samples. Higher DCK and RRM1 expression in AML patient's blast correlated with better DFS. Ara-C resistance index (RI), a mathematically derived quotient was proposed based on candidate gene expression pattern. Ara-C ex vivo sensitive samples were found to have significantly lower RI compared with resistant as well as samples from patients presenting with relapse. Patients with low RI supposedly highly sensitive to Ara-C were found to have higher incidence of induction death (p = 0.002; RR: 4.35 [95% CI: 1.69-11.22]). Global gene expression profiling undertaken to find out additional contributors of Ara-C resistance identified many apoptosis as well as metabolic pathway genes to be differentially expressed between Ara-C resistant and sensitive samples. This study highlights the importance of evaluating expression of candidate Ara-C metabolizing genes in predicting ex vivo drug response as well as treatment outcome. RI could be a predictor of ex vivo Ara-C response irrespective of cytogenetic and molecular risk groups and a potential biomarker for AML treatment outcome and toxicity. Original submitted 22 December 2014; Revision submitted 9 April 2015.

Star Scheduling Mode—A New Observing Strategy for Monitoring Weak Southern Radio Sources with the AuScope VLBI Array

NASA Astrophysics Data System (ADS)

McCallum, Lucia; Mayer, David; Le Bail, Karine; Schartner, Matthias; McCallum, Jamie; Lovell, Jim; Titov, Oleg; Shu, Fengchun; Gulyaev, Sergei

2017-11-01

The International Celestial Reference Frame suffers from significantly less observations in the southern hemisphere compared to the northern one. One reason for this is the historically low number of very long baseline interferometry radio telescopes in the south. The AuScope very long baseline interferometry array with three new telescopes on the Australian continent and an identical antenna in New Zealand were built to address this issue. While the overall number of observations in the south has greatly improved since then, a closer look reveals that this improvement is only true for strong radio sources (source flux densities >0.6 Jy). The new array of small very long baseline interferometry antennas has a relatively low baseline sensitivity so that only strong sources can be observed within a short integration time. A new observing strategy, the star scheduling mode, was developed to enable efficient observations of weak sources during geodetic sessions, through the addition of a single more sensitive antenna to the network. This scheduling mode was implemented in the Vienna very long baseline interferometry Software and applied in four 24-h sessions in 2016. These observations provide updated positions and source flux densities for 42 weak southern radio sources and significantly reduce the formal uncertainties for these sources. The star scheduling mode now allows the AuScope very long baseline interferometry array to undertake greater responsibility in monitoring sources in the southern sky, without significantly weakening the session for geodetic purposes.

The Gould’s Belt Very Large Array Survey. V. The Perseus Region

NASA Astrophysics Data System (ADS)

Pech, Gerardo; Loinard, Laurent; Dzib, Sergio A.; Mioduszewski, Amy J.; Rodríguez, Luis F.; Ortiz-León, Gisela N.; Rivera, Juana L.; Torres, Rosa M.; Boden, Andrew F.; Hartman, Lee; Kounkel, Marina A.; Evans, Neal J., II; Briceño, Cesar; Tobin, John; Zapata, Luis A.

2016-02-01

We present multiepoch, large-scale (˜2000 arcmin2), fairly deep (˜16 μJy), high-resolution (˜1″) radio observations of the Perseus star-forming complex obtained with the Karl G. Jansky Very Large Array at frequencies of 4.5 and 7.5 GHz. These observations were mainly focused on the clouds NGC 1333 and IC 348, although we also observed several fields in other parts of the Perseus complex. We detect a total of 206 sources, 42 of which are associated with young stellar objects (YSOs). The radio properties of about 60% of the YSOs are compatible with a nonthermal radio emission origin. Based on our sample, we find a fairly clear relation between the prevalence of nonthermal radio emission and evolutionary status of the YSOs. By comparing our results with previously reported X-ray observations, we show that YSOs in Perseus follow a Güdel-Benz relation with κ = 0.03, consistent with other regions of star formation. We argue that most of the sources detected in our observations but not associated with known YSOs are extragalactic, but provide a list of 20 unidentified radio sources whose radio properties are consistent with being YSO candidates. Finally, we also detect five sources with extended emission features that can clearly be associated with radio galaxies.

RADIO TRANSIENTS FROM ACCRETION-INDUCED COLLAPSE OF WHITE DWARFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moriya, Takashi J., E-mail: takashi.moriya@nao.ac.jp

2016-10-20

We investigate observational properties of accretion-induced collapse (AIC) of white dwarfs (WDs) in radio frequencies. If AIC is triggered by accretion from a companion star, a dense circumstellar medium can be formed around the progenitor system. Then, the ejecta from AIC collide with the dense circumstellar medium, creating a strong shock. The strong shock can produce synchrotron emission that can be observed in radio frequencies. Even if AIC occurs as a result of WD mergers, we argue that AIC may cause fast radio bursts (FRBs) if a certain condition is satisfied. If AIC forms neutron stars (NSs) that are somore » massive that rotation is required to support themselves (i.e., supramassive NSs), the supramassive NSs may immediately lose their rotational energy by the r-mode instability and collapse to black holes. If the collapsing supramassive NSs are strongly magnetized, they may emit FRBs, as previously proposed. The AIC radio transients from single-degenerate systems may be detected in future radio transient surveys like the Very Large Array Sky Survey or the Square Kilometer Array transient survey. Because AIC has been proposed as a source of gravitational waves (GWs), GWs from AIC may be accompanied by radio-bright transients that can be used to confirm the AIC origin of observed GWs.« less

Radio Observations of the Type IIP Supernova 20017eaw

NASA Astrophysics Data System (ADS)

Stockdale, Christopher; Perez-Torres, Miguel; Argo, Megan; Ryder, Stuart D.; Panagia, Nino; Van Dyk, Schuyler; Bauer, Franz Erik; Roming, Peter; Marcaide, Jon; Pooley, Dave; Lien, Amy; Sramek, Richard A.

2018-01-01

We present the results of radio observations of the type IIP Supernova 2017eaw using the Very Large Array and the eMERLIN radio telescopes at centimeter wavelengths. SN 2017eaw is a rare type IIP that did not show prompt radio emission after initial explosion. We will present our analysis of the current data and discuss the implications for the pre-explosion evolution of the progenitor star of SN 20017eaw. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities.

Gamma-ray burster counterparts - Radio

NASA Technical Reports Server (NTRS)

Schaefer, Bradley E.; Cline, Thomas L.; Desai, U. D.; Teegarden, B. J.; Atteia, J.-L.; Barat, C.; Estulin, I. V.; Evans, W. D.; Fenimore, E. E.; Hurley, K.

1989-01-01

Many observers and theorists have suggested that gamma-ray bursters (GRBs) are related to highly magnetized rotating, neutron stars, in which case an analogy with pulsars implies that GRBs would be prodigious emitters of polarized radio emission during quiescence. The paper reports on a survey conducted with the Very Large Array radio telescope of 10 small GRB error regions for quiescent radio emission at wavelengths of 2, 6, and 20 cm. The sensitivity of the survey varied from 0.1 to 0.8 mJy. The observations did indeed reveal four radio sources inside the GRB error regions.

Radio emission from embryonic superluminous supernova remnants

NASA Astrophysics Data System (ADS)

Omand, Conor M. B.; Kashiyama, Kazumi; Murase, Kohta

2018-02-01

It has been widely argued that Type-I superluminous supernovae (SLSNe-I) are driven by powerful central engines with a long-lasting energy injection after the core-collapse of massive progenitors. One of the popular hypotheses is that the hidden engines are fast-rotating pulsars with a magnetic field of B ˜ 1013-1015 G. Murase, Kashiyama & Mészáros proposed that quasi-steady radio/submm emission from non-thermal electron-positron pairs in nascent pulsar wind nebulae can be used as a relevant counterpart of such pulsar-driven supernovae (SNe). In this work, focusing on the nascent SLSN-I remnants, we examine constraints that can be placed by radio emission. We show that the Atacama Large Millimeter/submillimetre Array can detect the radio nebula from SNe at DL ˜ 1 Gpc in a few years after the explosion, while the Jansky Very Large Array can also detect the counterpart in a few decades. The proposed radio follow-up observation could solve the parameter degeneracy in the pulsar-driven SN model for optical/UV light curves, and could also give us clues to young neutron star scenarios for SLSNe-I and fast radio bursts.

The Gould's Belt Very Large Array Survey. IV. The Taurus-Auriga Complex

NASA Astrophysics Data System (ADS)

Dzib, Sergio A.; Loinard, Laurent; Rodríguez, Luis F.; Mioduszewski, Amy J.; Ortiz-León, Gisela N.; Kounkel, Marina A.; Pech, Gerardo; Rivera, Juana L.; Torres, Rosa M.; Boden, Andrew F.; Hartmann, Lee; Evans, Neal J., II; Briceño, Cesar; Tobin, John

2015-03-01

We present a multi-epoch radio study of the Taurus-Auriga star-forming complex made with the Karl G. Jansky Very Large Array at frequencies of 4.5 GHz and 7.5 GHz. We detect a total of 610 sources, 59 of which are related to young stellar objects (YSOs) and 18 to field stars. The properties of 56% of the young stars are compatible with non-thermal radio emission. We also show that the radio emission of more evolved YSOs tends to be more non-thermal in origin and, in general, that their radio properties are compatible with those found in other star-forming regions. By comparing our results with previously reported X-ray observations, we notice that YSOs in Taurus-Auriga follow a Güdel-Benz relation with κ = 0.03, as we previously suggested for other regions of star formation. In general, YSOs in Taurus-Auriga and in all the previous studied regions seem to follow this relation with a dispersion of ~1 dex. Finally, we propose that most of the remaining sources are related with extragalactic objects but provide a list of 46 unidentified radio sources whose radio properties are compatible with a YSO nature.

Achievements of the Armenian Astronomy and the Present Activities of the Armenian Astronomical Society

NASA Astrophysics Data System (ADS)

Mickaelian, A. M.

2014-10-01

A report is given on the achievements of the Armenian astronomy during the last years and on the present activities of the Armenian Astronomical Society (ArAS). ArAS membership, ArAS electronic newsletters (ArASNews), ArAS webpage, international collaboration, Armenian Virtual Observatory (ArVO), membership in international organizations, grants, prizes, meetings, summer schools, astronomical Olympiads, other matters related to astronomical education, archaeoastronomy, astronomy outreach and ArAS further projects are discussed.

Heat processing of peanut seed enhances the sensitization potential of the major peanut allergen Ara h 6.

PubMed

Guillon, Blanche; Bernard, Hervé; Drumare, Marie-Françoise; Hazebrouck, Stéphane; Adel-Patient, Karine

2016-12-01

Processing of food has been shown to impact IgE binding and functionality of food allergens. In the present study, we investigated the impact of heat processing on the sensitization capacity of Ara h 6, a major peanut allergen and one of the most potent elicitors of the allergic reaction. Peanut extracts obtained from raw or heat-processed peanut and some fractions thereof were biochemically and immunochemically characterized. These extracts/fractions, purified Ara h 6, or recombinant Ara h 6 including Ara h 6 mutants lacking disulfide bridges were used in in vitro digestion tests and mouse models of experimental sensitization. Peanut roasting led to the formation of complexes of high molecular weight, notably between Ara h 6 and Ara h 1, which supported the induction of IgE specific to native Ara h 6. On the contrary, a fraction containing free monomeric 2S albumins or purified native Ara h 6 displayed no intrinsic allergenicity. In addition to complex formation, heat denaturation and/or partial destabilization enhanced Ara h 6 immunogenicity and increased its sensitivity to digestion. These results suggest that sensitization potency and IgE binding capacity can be supported by different structures, modified and/or produced during food processing in interaction with other food constituents. © 2016 The Authors. Molecular Nutrition & Food Research published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

PubMed Central

Huber, B E; Richards, C A; Krenitsky, T A

1991-01-01

An approach involving retroviral-mediated gene therapy for the treatment of neoplastic disease is described. This therapeutic approach is called "virus-directed enzyme/prodrug therapy" (VDEPT). The VDEPT approach exploits the transcriptional differences between normal and neoplastic cells to achieve selective killing of neoplastic cells. We now describe development of the VDEPT approach for the treatment of hepatocellular carcinoma. Replication-defective, amphotrophic retroviruses were constructed containing a chimeric varicella-zoster virus thymidine kinase (VZV TK) gene that is transcriptionally regulated by either the hepatoma-associated alpha-fetoprotein or liver-associated albumin transcriptional regulatory sequences. Subsequent to retroviral infection, expression of VZV TK was limited to either alpha-fetoprotein- or albumin-positive cells, respectively. VZV TK metabolically activated the nontoxic prodrug 6-methoxypurine arabinonucleoside (araM), ultimately leading to the formation of the cytotoxic anabolite adenine arabinonucleoside triphosphate (araATP). Cells that selectively expressed VZV TK became selectively sensitive to araM due to the VZV TK-dependent anabolism of araM to araATP. Hence, these retroviral-delivered chimeric genes generated tissue-specific expression of VZV TK, tissue-specific anabolism of araM to araATP, and tissue-specific cytotoxicity due to araM exposure. By utilizing such retroviral vectors, araM was anabolized to araATP in hepatoma cells, producing a selective cytotoxic effect. Images PMID:1654555

Detection of Peanut Allergen Ara h 6 in Commercially Processed Foods using a Single-Walled Carbon Nanotube-Based Biosensor.

PubMed

Sobhan, Abdus; Oh, Jun-Hyun; Park, Mi-Kyung; Lee, Jinyoung

2018-06-12

Background : The peanut protein Arachis hypogaea (Ara h) 6 is one ofthe most serious food allergens that contributes to food-related, life-threatening problems worldwide. The extremely low allergic dose demands for more selective and rapid methods for detecting Ara h 6. Objective : The goal of this study was to develop a single-walled carbon nanotube (SWCNT)-based biosensor for the rapid detection of Ara h 6 in commercial food products. Methods : The detection principle of this biosensor was based on the binding of Ara h 6 to the anti-Ara h 6 antibody (pAb) through 1-pyrenibutanoic acid succinimidyl ester. The resistance difference (ΔR) was calculated via linear sweep voltammetry using a potentiostat. Results : The ∆R increased as the Ara h 6 concentrations increased above the range of 10 0 -10 7 pg/L. A specificity analysis showed that the anti-Ara h 6 pAb selectively interacted with Ara h 6 molecules in the buffer solution (pH 7.4). Conclusions : This research proposes that an SWCNT-based biosensor in self-assembly with antibodies could be an effective tool for the rapid detection of allergen proteins in food. Highlights : The developed biosensor exhibited higher sensitivity and selectivity. Application studies resulted in precise Ara h 6 detection in peanut-containing processed food.

EXCESS OPTICAL ENHANCEMENT OBSERVED WITH ARCONS FOR EARLY CRAB GIANT PULSES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strader, M. J.; Mazin, B. A.; Spiro Jaeger, G. V.

2013-12-10

We observe an extraordinary link in the Crab pulsar between the enhancement of an optical pulse and the timing of the corresponding giant radio pulse. At optical through infrared wavelengths, our observations use the high time resolution of ARray Camera for Optical to Near-IR Spectrophotometry, a unique superconducting energy-resolving photon-counting array at the Palomar 200 inch telescope. At radio wavelengths, we observe with the Robert C. Byrd Green Bank Telescope and the Green Bank Ultimate Pulsar Processing Instrument backend. We see an 11.3% ± 2.5% increase in peak optical flux for pulses that have an accompanying giant radio pulse arrivingmore » near the peak of the optical main pulse, in contrast to a 3.2% ± 0.5% increase when an accompanying giant radio pulse arrives soon after the optical peak. We also observe that the peak of the optical main pulse is 2.8% ± 0.8% enhanced when there is a giant radio pulse accompanying the optical interpulse. We observe no statistically significant spectral differences between optical pulses accompanied by and not accompanied by giant radio pulses. Our results extend previous observations of optical-radio correlation to the time and spectral domains. Our refined temporal correlation suggests that optical and radio emission are indeed causally linked, and the lack of spectral differences suggests that the same mechanism is responsible for all optical emission.« less

Excess optical enhancement observed with arcons for early crab giant pulses

DOE PAGES

Strader, M. J.; Johnson, M. D.; Mazin, B. A.; ...

2013-11-26

Here, we observe an extraordinary link in the Crab pulsar between the enhancement of an optical pulse and the timing of the corresponding giant radio pulse. At optical through infrared wavelengths, our observations use the high time resolution of ARray Camera for Optical to Near-IR Spectrophotometry, a unique superconducting energy-resolving photon-counting array at the Palomar 200 inch telescope. At radio wavelengths, we observe with the Robert C. Byrd Green Bank Telescope and the Green Bank Ultimate Pulsar Processing Instrument backend. We see an 11.3% ± 2.5% increase in peak optical flux for pulses that have an accompanying giant radio pulsemore » arriving near the peak of the optical main pulse, in contrast to a 3.2% ± 0.5% increase when an accompanying giant radio pulse arrives soon after the optical peak. We also observe that the peak of the optical main pulse is 2.8% ± 0.8% enhanced when there is a giant radio pulse accompanying the optical interpulse. We also observe no statistically significant spectral differences between optical pulses accompanied by and not accompanied by giant radio pulses. These results extend previous observations of optical-radio correlation to the time and spectral domains. Our refined temporal correlation suggests that optical and radio emission are indeed causally linked, and the lack of spectral differences suggests that the same mechanism is responsible for all optical emission.« less

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

PubMed

Smelick, Gillian S; Heffron, Timothy P; Chu, Laura; Dean, Brian; West, David A; Duvall, Scott L; Lum, Bert L; Budha, Nageshwar; Holden, Scott N; Benet, Leslie Z; Frymoyer, Adam; Dresser, Mark J; Ware, Joseph A

2013-11-04

Acid-reducing agents (ARAs) are the most commonly prescribed medications in North America and Western Europe. There are currently no data describing the prevalence of their use among cancer patients. However, this is a paramount question due to the potential for significant drug-drug interactions (DDIs) between ARAs, most commonly proton pump inhibitors (PPIs), and orally administered cancer therapeutics that display pH-dependent solubility, which may lead to decreased drug absorption and decreased therapeutic benefit. Of recently approved orally administered cancer therapeutics, >50% are characterized as having pH-dependent solubility, but there are currently no data describing the potential for this ARA-DDI liability among targeted agents currently in clinical development. The objectives of this study were to (1) determine the prevalence of ARA use among different cancer populations and (2) investigate the prevalence of orally administered cancer therapeutics currently in development that may be liable for an ARA-DDI. To address the question of ARA use among cancer patients, a retrospective cross-sectional analysis was performed using two large healthcare databases: Thomson Reuters MarketScan (N = 1,776,443) and the U.S. Department of Veterans Affairs (VA, N = 1,171,833). Among all cancer patients, the total prevalence proportion of ARA use (no. of cancer patients receiving an ARA/total no. of cancer patients) was 20% and 33% for the MarketScan and VA databases, respectively. PPIs were the most commonly prescribed agent, comprising 79% and 65% of all cancer patients receiving a prescription for an ARA (no. of cancer patients receiving a PPI /no. of cancer patients receiving an ARA) for the MarketScan and VA databases, respectively. To estimate the ARA-DDI liability of orally administered molecular targeted cancer therapeutics currently in development, two publicly available databases, (1) Kinase SARfari and (2) canSAR, were examined. For those orally administered clinical candidates that had available structures, the pKa's and corresponding relative solubilities were calculated for a normal fasting pH of 1.2 and an "ARA-hypochlorhydric" pH of 4. Taking calculated pKa's and relative solubilities into consideration, clinical candidates were classified based on their risk for an ARA-DDI. More than one-quarter (28%) of the molecules investigated are at high risk for an ARA-DDI, and of those high risk molecules, nearly three-quarters (73%) are being clinically evaluated for at least one of five cancer types with the highest prevalence of ARA use (gastrointestinal, pancreatic, lung, glioblastoma multiforme, gastrointestinal stromal tumor (GIST)). These data strongly suggest that with the clinical development of ARA-DDI-susceptible cancer therapeutics will come continued challenges for drug-development scientists, oncologists, and regulatory agencies in ensuring that patients achieve safe and efficacious exposures of their cancer therapeutics and thus optimal patient outcomes.

Improving MWA/HERA Calibration Using Extended Radio Source Models

NASA Astrophysics Data System (ADS)

Cunningham, Devin; Tasker, Nicholas; University of Washington EoR Imaging Team

2018-01-01

The formation of the first stars and galaxies in the universe is among the greatest mysteries in astrophysics. Using special purpose radio interferometers, it is possible to detect the faint 21 cm radio line emitted by neutral hydrogen in order to characterize the Epoch of Reionization (EoR) and the formation of the first stars and galaxies. We create better models of extended radio sources by reducing component number of deconvolved Murchison Widefield Array (MWA) data by up to 90%, while preserving real structure and flux information. This real structure is confirmed by comparisons to observations of the same extended radio sources from the TIFR GMRT Sky Survey (TGSS) and NRAO VLA Sky Survey (NVSS), which detect at a similar frequency range as the MWA. These sophisticated data reduction techniques not only offer improvements to the calibration of the MWA, but also hold applications for the future sky-based calibration of the Hydrogen Epoch of Reionization Array (HERA). This has the potential to reduce noise in the power spectra from these instruments, and consequently provide a deeper view into the window of EoR.

GIGAS: A set of microwave sensor arrays to detect molecular bremsstrahlung radiation from extensive air shower

NASA Astrophysics Data System (ADS)

Gaïor, R.; Al Samarai, I.; Berat, C.; Blanco Otano, M.; David, J.; Deligny, O.; Lebbolo, H.; Lecoz, S.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Mariş, I. C.; Montanet, F.; Repain, P.; Salamida, F.; Settimo, M.; Stassi, P.; Stutz, A.

2018-04-01

We present the GIGAS (Gigahertz Identification of Giant Air Shower) microwave radio sensor arrays of the EASIER project (Extensive Air Shower Identification with Electron Radiometers), deployed at the site of the Pierre Auger cosmic ray observatory. The aim of these novel arrays is to probe the intensity of the molecular bremsstrahlung radiation expected from the development of the extensive air showers produced by the interaction of ultra high energy cosmic rays in the atmosphere. In the designed setup, the sensors are embedded within the surface detector array of the Pierre Auger observatory allowing us to use the particle signals at ground level to trigger the radio system. A series of seven, then 61 sensors have been deployed in the C-band, followed by a new series of 14 higher sensitivity ones in the C-band and the L-band. The design, the operation, the calibration and the sensitivity to extensive air showers of these arrays are described in this paper.

Mechanism of interaction of the antileukemic drug cytosine arabinoside with aromatic peptides: role of sugar conformation and peptide backbone.

PubMed

Datta, G; Hosur, R V; Verma, N C; Khetrapal, C L; Gurnani, S

1989-01-01

Interaction of the antileukemic drugs, cytosine-arabinoside (Ara-C) and adenosine-arabinoside (Ara-A) and a structural analogue, cytidine, with aromatic dipeptides has been studied by fluorescence and NMR spectroscopy. Ara-C and cytidine bind tryptophanyl and histidyl dipeptides but not tyrosyl dipeptides, while Ara-A does not bind to any of them. Both studies indicate association involving stacking of aromatic moieties. NMR spectra also indicate a protonation of the histidine moiety by Ara-C. In case of cytidine, the chemical shifts observed on binding to His-Phe imply that the backbone protons of the dipeptide participate in the binding. The conformation of the sugar and the base seem to play a very important role in the binding phenomenon as three similar molecules, Ara-C, Ara-A and cytidine bind in totally different ways.

The Astronomical Low-Frequency Array

NASA Technical Reports Server (NTRS)

Jones, D. L.; Allen, R. J.; Blume, W. H.; Desch, M. M.; Erickson, W. C.; Kaiser, M. L.; Kassim, N. E.; Kuiper, T. B. H.; Mahoney, M. J.; Marsh, K. A.;

Accelerator-based method of producing isotopes

DOEpatents

Nolen, Jr., Jerry A.; Gomes, Itacil C.

2015-11-03

The invention provides a method using accelerators to produce radio-isotopes in high quantities. The method comprises: supplying a "core" of low-enrichment fissile material arranged in a spherical array of LEU combined with water moderator. The array is surrounded by substrates which serve as multipliers and moderators as well as neutron shielding substrates. A flux of neutrons enters the low-enrichment fissile material and causes fissions therein for a time sufficient to generate desired quantities of isotopes from the fissile material. The radio-isotopes are extracted from said fissile material by chemical processing or other means.

Amateur Planetary Radio Data Archived for Science and Education: Radio Jove

NASA Astrophysics Data System (ADS)

Thieman, J.; Cecconi, B.; Sky, J.; Garcia, L. N.; King, T. A.; Higgins, C. A.; Fung, S. F.

2015-12-01

The Radio Jove Project is a hands-on educational activity in which students, teachers, and the general public build simple radio telescopes, usually from a kit, to observe single frequency decameter wavelength radio emissions from Jupiter, the Sun, the galaxy, and the Earth usually with simple dipole antennas. Some of the amateur observers have upgraded their receivers to spectrographs and their antennas have become more sophisticated as well. The data records compare favorably to more sophisticated professional radio telescopes such as the Long Wavelength Array (LWA) and the Nancay Decametric Array. Since these data are often carefully calibrated and recorded around the clock in widely scattered locations they represent a valuable database useful not only to amateur radio astronomers but to the professional science community as well. Some interesting phenomena have been noted in the data that are of interest to the professionals familiar with such records. The continuous monitoring of radio emissions from Jupiter could serve as useful "ground truth" data during the coming Juno mission's radio observations of Jupiter. Radio Jove has long maintained an archive for thousands of Radio Jove observations, but the database was intended for use by the Radio Jove participants only. Now, increased scientific interest in the use of these data has resulted in several proposals to translate the data into a science community data format standard and store the data in professional archives. Progress is being made in translating Radio Jove data to the Common Data Format (CDF) and also in generating new observations in that format as well. Metadata describing the Radio Jove data would follow the Space Physics Archive Search and Extract (SPASE) standard. The proposed archive to be used for long term preservation would be the Planetary Data System (PDS). Data sharing would be achieved through the PDS and the Paris Astronomical Data Centre (PADC) and the Virtual Wave Observatory (VWO). We believe that Radio Jove represents another fertile area for citizen science to contribute to overall scientific investigation.

Non-convex optimization for self-calibration of direction-dependent effects in radio interferometric imaging

NASA Astrophysics Data System (ADS)

Repetti, Audrey; Birdi, Jasleen; Dabbech, Arwa; Wiaux, Yves

2017-10-01

Radio interferometric imaging aims to estimate an unknown sky intensity image from degraded observations, acquired through an antenna array. In the theoretical case of a perfectly calibrated array, it has been shown that solving the corresponding imaging problem by iterative algorithms based on convex optimization and compressive sensing theory can be competitive with classical algorithms such as clean. However, in practice, antenna-based gains are unknown and have to be calibrated. Future radio telescopes, such as the Square Kilometre Array, aim at improving imaging resolution and sensitivity by orders of magnitude. At this precision level, the direction-dependency of the gains must be accounted for, and radio interferometric imaging can be understood as a blind deconvolution problem. In this context, the underlying minimization problem is non-convex, and adapted techniques have to be designed. In this work, leveraging recent developments in non-convex optimization, we propose the first joint calibration and imaging method in radio interferometry, with proven convergence guarantees. Our approach, based on a block-coordinate forward-backward algorithm, jointly accounts for visibilities and suitable priors on both the image and the direction-dependent effects (DDEs). As demonstrated in recent works, sparsity remains the prior of choice for the image, while DDEs are modelled as smooth functions of the sky, I.e. spatially band-limited. Finally, we show through simulations the efficiency of our method, for the reconstruction of both images of point sources and complex extended sources. matlab code is available on GitHub.

Isolation and characterization of natural Ara h 6: evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat.

PubMed

Suhr, Martin; Wicklein, Daniel; Lepp, Ute; Becker, Wolf-Meinhard

2004-10-01

Peanut allergy is a significant health problem because of its prevalence and the potential severity of the allergic reaction. The characterization of peanut allergens is crucial to the understanding of the mechanism of peanut allergy. Recently, we described cloning of the peanut allergen Ara h 6. The aim of this study was isolation and further characterization of nAra h 6. We purified nAra h 6 from crude peanut extract using gel filtration and anion exchange chromatography. The preparation was further characterized by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) with subsequent immunoblotting. Stability of nAra h 6 was studied by an in vitro digestibility assay as well as by resistance against thermal processing. Sequencing of nAra h 6 identified the N-terminal amino acid sequence as MRRERGRQGDSSS. Further results clearly demonstrated stability of nAra h 6 against pepsin digestion and heating. Immunoglobulin G (IgE) binding analysis and its biological activity shown by RBL 25/30-test of natural Ara h 6 supported the importance of this peanut allergen. Investigation of nAra h 6 revealed evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat.

Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders.

PubMed

Edlow, Brian L; Takahashi, Emi; Wu, Ona; Benner, Thomas; Dai, Guangping; Bu, Lihong; Grant, Patricia Ellen; Greer, David M; Greenberg, Steven M; Kinney, Hannah C; Folkerth, Rebecca D

2012-06-01

The ascending reticular activating system (ARAS) mediates arousal, an essential component of human consciousness. Lesions of the ARAS cause coma, the most severe disorder of consciousness. Because of current methodological limitations, including of postmortem tissue analysis, the neuroanatomic connectivity of the human ARAS is poorly understood. We applied the advanced imaging technique of high angular resolution diffusion imaging (HARDI) to elucidate the structural connectivity of the ARAS in 3 adult human brains, 2 of which were imaged postmortem. High angular resolution diffusion imaging tractography identified the ARAS connectivity previously described in animals and also revealed novel human pathways connecting the brainstem to the thalamus, the hypothalamus, and the basal forebrain. Each pathway contained different distributions of fiber tracts from known neurotransmitter-specific ARAS nuclei in the brainstem. The histologically guided tractography findings reported here provide initial evidence for human-specific pathways of the ARAS. The unique composition of neurotransmitter-specific fiber tracts within each ARAS pathway suggests structural specializations that subserve the different functional characteristics of human arousal. This ARAS connectivity analysis provides proof of principle that HARDI tractography may affect the study of human consciousness and its disorders, including in neuropathologic studies of patients dying in coma and the persistent vegetative state.

Testing the antidepressant properties of the peptide ARA290 in a human neuropsychological model of drug action.

PubMed

Cerit, Hilâl; Veer, Ilya M; Dahan, Albert; Niesters, Marieke; Harmer, Catherine J; Miskowiak, Kamilla W; Rombouts, Serge A R B; Van der Does, Willem

2015-12-01

Studies on the neural effects of Erythropoietin (EPO) indicate that EPO may have antidepressant effects. Due to its hematopoietic effects, EPO may cause serious side-effects with repeated administration if patients are not monitored extensively. ARA290 is an EPO-analog peptide without such hematopoietic side-effects but may have neurotrophic and antidepressant effects. The aim of this study was to investigate the possible antidepressant effects of ARA290 in a neuropsychological model of drug action. Healthy participants (N=36) received ARA290 (2mg) or placebo in a double-blind, randomized, parallel-group design. Neural and cognitive effects were assessed one week after administration. Primary outcome measures were the neural processing of fearful vs happy faces and the behavioral recognition of emotional facial expressions. ARA290-treated individuals displayed lower neural responses to happy faces in the fusiform gyrus. ARA290 tended to lower the recognition of happy and disgust facial expressions. Although ARA290 was not associated with a better memory for positive words, it was associated with faster categorization of positive vs negative words. Finally, ARA290 increased attention towards positive emotional pictures. No effects were observed on mood and affective symptoms. ARA290 may modulate some aspects of emotional processing, however, the direction and the strength of its effects do not unequivocally support an antidepressant-like profile for ARA290. Future studies may investigate the effects of different timing and dose. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

Prevalence and predictors of renal artery stenosis in patients undergoing peripheral and coronary angiography.

PubMed

Shukla, Anand N; Madan, Tarun H; Jayaram, Ashwal A; Kute, Vivek B; Rawal, Jayesh R; Manjunath, A P; Udhreja, Satyam

2013-12-01

Renal artery stenosis is a potential cause of secondary hypertension, ischemic nephropathy and end-stage renal disease. Atherosclerosis is by far the most common etiology of renal artery stenosis in elderly. We investigated whether the presence of significant atherosclerotic renal artery stenosis (ARAS) with luminal diameter narrowing ≥50 % could be predicted in patients undergoing peripheral and coronary angiography. The records of 3,500 consecutive patients undergoing simultaneous renal angiography along with peripheral and coronary angiography were reviewed. The patients with known renal artery disease were excluded. Prevalence of ARAS was 5.7 %. Significant ARAS (luminal diameter narrowing ≥50 %) was present in 139 patients (3.9 %). Hypertension with altered serum creatinine and triple-vessel CAD were associated with significant renal artery stenosis in multivariate analysis. No significant relationship between the involved coronary arteries like left anterior descending, left circumflex, right coronary artery and ARAS was found. Only hypertension and altered serum creatinine were associated with bilateral ARAS. Extent of CAD or risk factors like diabetes, hyperlipidemia or smoking did not predict the unilateral or bilateral ARAS. Prevalence of ARAS among the patients in routine cardiac catheterization was 5.7 %. Hypertension is closely associated with significant ARAS. Significant CAD in the form of triple-vessel disease and altered renal function tests are closely associated with ARAS. They predict the presence of significant renal artery stenosis in patients undergoing routine peripheral and coronary angiography. Moreover, hypertension and altered renal functions predict bilateral ARAS.

Radio observations of GRB 100418a: Test of an energy injection model explaining long-lasting GRB afterglows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moin, A.; Wang, Z.; Chandra, P.

We present the results of our radio observational campaign of gamma-ray burst (GRB) 100418a, for which we used the Australia Telescope Compact Array, the Very Large Array, and the Very Long Baseline Array. GRB 100418a was a peculiar GRB with unusual X-ray and optical afterglow profiles featuring a plateau phase with a very shallow rise. This observed plateau phase was believed to be due to a continued energy injection mechanism that powered the forward shock, giving rise to an unusual and long-lasting afterglow. The radio afterglow of GRB 100418a was detectable several weeks after the prompt emission. We conducted long-termmore » monitoring observations of the afterglow and attempted to test the energy injection model advocating that the continuous energy injection is due to shells of material moving at a wide range of Lorentz factors. We obtained an upper limit of γ < 7 for the expansion rate of the GRB 100418a radio afterglow, indicating that the range-of-Lorentz factor model could only be applicable for relatively slow-moving ejecta. A preferred explanation could be that continued activity of the central engine may have powered the long-lasting afterglow.« less

LIMITS ON THE EVENT RATES OF FAST RADIO TRANSIENTS FROM THE V-FASTR EXPERIMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wayth, Randall B.; Tingay, Steven J.; Deller, Adam T.

2012-07-10

We present the first results from the V-FASTR experiment, a commensal search for fast transient radio bursts using the Very Long Baseline Array (VLBA). V-FASTR is unique in that the widely spaced VLBA antennas provide a discriminant against non-astronomical signals and a mechanism for the localization and identification of events that is not possible with single dishes or short baseline interferometers. Thus, far V-FASTR has accumulated over 1300 hr of observation time with the VLBA, between 90 cm and 3 mm wavelength (327 MHz-86 GHz), providing the first limits on fast transient event rates at high radio frequencies (>1.4 GHz).more » V-FASTR has blindly detected bright individual pulses from seven known pulsars but has not detected any single-pulse events that would indicate high-redshift impulsive bursts of radio emission. At 1.4 GHz, V-FASTR puts limits on fast transient event rates comparable with the PALFA survey at the Arecibo telescope, but generally at lower sensitivities, and comparable to the 'fly's eye' survey at the Allen Telescope Array, but with less sky coverage. We also illustrate the likely performance of the Phase 1 SKA dish array for an incoherent fast transient search fashioned on V-FASTR.« less

Prospective investigation on the transfer of Ara h 2, the most potent peanut allergen, in human breast milk.

PubMed

Schocker, Frauke; Baumert, Joseph; Kull, Skadi; Petersen, Arnd; Becker, Wolf-Meinhard; Jappe, Uta

2016-06-01

Peanut allergy is one of the most severe food allergies. Whether breastfeeding induces tolerance to peanuts or on the contrary, pre-disposes at risk-babies to occult allergic sensitization to peanuts is still a matter of discussion. We sought to investigate the transfer of the most potent peanut allergen Ara h 2 into human breast milk in a German breast milk study and to shed light on the time kinetics of Ara h 2 appearance. We recruited 32 lactating, non-peanut-allergic women and collected breast milk samples at different time points after consumption of 100 g dry roasted peanuts. Breast milk samples were investigated for Ara h 2 with different immunological methods: by 2D immunoblotting with a patient's serum, by affinity enrichment using a monoclonal antibody against Ara h 2 followed by LC-MS/MS-based detection and by a competitive inhibition ELISA for the detection of Ara h 2 and its digestion-resistant peptides (DRP-Ara h 2). In a qualitative analysis, Ara h 2 could be identified in a breast milk sample by 2D immunoblot by means of a patient's serum and furthermore by immunoaffinity enrichment followed by LC-MS/MS analysis. In a semi-quantitative analysis, Ara h 2 and its digestion-resistant peptides were detected in the breast milk of 9 of 32 subjects. Evidence suggests that Ara h 2 is excreted individually either rapidly (after 1, 2, 3 or 4 h) or delayed (after 8 or 12 h) and in different concentrations. Time and concentration of secreted Ara h 2 in breast milk appears to be individually regulated. The identification of Ara h 2 in breast milk is the prerequisite for the investigation of its sensitizing or tolerogenic properties. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Influence of peanut matrix on stability of allergens in gastric-simulated digesta: 2S albumins are main contributors to the IgE reactivity of short digestion-resistant peptides.

PubMed

Prodic, I; Stanic-Vucinic, D; Apostolovic, D; Mihailovic, J; Radibratovic, M; Radosavljevic, J; Burazer, L; Milcic, M; Smiljanic, K; van Hage, M; Cirkovic Velickovic, T

2018-06-01

Most food allergens sensitizing via the gastrointestinal tract are stable proteins that are resistant to pepsin digestion, in particular major peanut allergens, Ara h 2 and Ara h 6. Survival of their large fragments is essential for sensitizing capacity. However, the immunoreactive proteins/peptides to which the immune system of the gastrointestinal tract is exposed during digestion of peanut proteins are unknown. Particularly, the IgE reactivity of short digestion-resistant peptides (SDRPs; <10 kDa) released by gastric digestion under standardized and physiologically relevant in vitro conditions has not been investigated. The aim of this study was to investigate and identify digestion products of major peanut allergens and in particular to examine IgE reactivity of SDRPs released by pepsin digestion of whole peanut grains. Two-dimensional gel-based proteomics and shotgun peptidomics, immunoblotting with allergen-specific antibodies from peanut-sensitized patients, enzyme-linked immunosorbent inhibition assay and ImmunoCAP tests, including far ultraviolet-circular dichroism spectroscopy were used to identify and characterize peanut digesta. Ara h 2 and Ara h 6 remained mostly intact, and SDRPs from Ara h 2 were more potent in inhibiting IgE binding than Ara h 1 and Ara 3. Ara h 1 and Ara h 3 exhibited sequential digestion into a series of digestion-resistant peptides with preserved allergenic capacity. A high number of identified SDRPs from Ara h 1, Ara h 2 and Ara h 3 were part of short continuous epitope sequences and possessed substantial allergenic potential. Peanut grain digestion by oral and gastric phase enzymes generates mixture of products, where the major peanut allergens remain intact and their digested peptides have preserved allergenic capacity highlighting their important roles in allergic reactions to peanut. © 2018 John Wiley & Sons Ltd.

Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.

PubMed

Percival, Elizabeth; Bhatia, Rani; Preece, Kahn; McElduff, Patrick; McEvoy, Mark; Collison, Adam; Mattes, Joerg

2016-01-01

Ara h2 sIgE serum levels improve the diagnostic accuracy for predicting peanut allergy, but the use of Ara h2 purified protein as a skin prick test (SPT), has not been substantially evaluated. The fraction of exhaled nitric oxide (FeNO) shows promise as a novel biomarker of peanut allergy. Reproducibility of these measures has not been determined. The aim was to assess the accuracy and reproducibility (over a time-period of at least 12 months) of SPT to Ara h2 in comparison with four predictors of clinical peanut allergy (Peanut SPT, Ara h2 specific Immunoglobulin E (sIgE), Peanut sIgE and FeNO). Twenty-seven children were recruited in a follow-up of a prospective cohort of fifty-six children at least 12 months after an open-labelled peanut food challenge. Their repeat assessment involved a questionnaire, SPT to peanut and Ara h2 purified protein, FeNO and sIgE to peanut and Ara h2 measurements. Ara h2 SPT was no worse in accuracy when compared with peanut SPT, FeNO, Ara h2 sIgE and peanut sIgE (AUC 0.908 compared with 0.887, 0.889, 0.935 and 0.804 respectively) for predicting allergic reaction at previous food challenge. SPT for peanut and Ara h2 demonstrated limited reproducibility (ICC = 0.51 and 0.44); while FeNO demonstrated good reproducibility (ICC = 0.73) and sIgE for peanut and Ara h2 were highly reproducible (ICC = 0.81 and 0.85). In this population, Ara h2 SPT was no worse in accuracy when compared with current testing for the evaluation of clinical peanut allergy, but had-like peanut SPT-poor reproducibility. FeNO, peanut sIgE and Ara h2 sIgE were consistently reproducible despite an interval of at least 12 months between the repeated measurements.

47 CFR 25.226 - Blanket Licensing provisions for domestic, U.S. Vehicle-Mounted Earth Stations (VMESs) receiving...

Code of Federal Regulations, 2013 CFR

2013-10-01

... vicinity of radio astronomy service (RAS) observatories observing in the 14.47-14.5 GHz band are subject to... RAS site, its location, and the applicable coordination zone. Table 1—Applicable Radio Astronomy... Radio Astronomy Observatory, Stinchfield Woods, MI 42°23′56″ 83°56′11″ 160. Very Long Baseline Array...

A multidisciplinary study of planetary, solar and astrophysical radio emissions

NASA Technical Reports Server (NTRS)

Gurnett, D. A.; Calvert, W.; Fielder, R.; Goertz, C.; Grabbe, C.; Kurth, W.; Mutel, R.; Sheerin, J.; Mellott, M.; Spangler, S.

1986-01-01

Combination of the related fields of planetary, solar, and astrophysical radio emissions was attempted in order to more fully understand the radio emission processes. Topics addressed include: remote sensing of astrophysical plasma turbulence; Alfven waves; astrophysical shock waves; surface waves; very long base interferometry results; very large array observations; solar magnetic flux; and magnetohydrodynamic waves as a tool for solar corona diagnostics.

The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey

NASA Astrophysics Data System (ADS)

Bannister, K. W.; Shannon, R. M.; Macquart, J.-P.; Flynn, C.; Edwards, P. G.; O'Neill, M.; Osłowski, S.; Bailes, M.; Zackay, B.; Clarke, N.; D'Addario, L. R.; Dodson, R.; Hall, P. J.; Jameson, A.; Jones, D.; Navarro, R.; Trinh, J. T.; Allison, J.; Anderson, C. S.; Bell, M.; Chippendale, A. P.; Collier, J. D.; Heald, G.; Heywood, I.; Hotan, A. W.; Lee-Waddell, K.; Madrid, J. P.; Marvil, J.; McConnell, D.; Popping, A.; Voronkov, M. A.; Whiting, M. T.; Allen, G. R.; Bock, D. C.-J.; Brodrick, D. P.; Cooray, F.; DeBoer, D. R.; Diamond, P. J.; Ekers, R.; Gough, R. G.; Hampson, G. A.; Harvey-Smith, L.; Hay, S. G.; Hayman, D. B.; Jackson, C. A.; Johnston, S.; Koribalski, B. S.; McClure-Griffiths, N. M.; Mirtschin, P.; Ng, A.; Norris, R. P.; Pearce, S. E.; Phillips, C. J.; Roxby, D. N.; Troup, E. R.; Westmeier, T.

2017-05-01

We report the detection of an ultra-bright fast radio burst (FRB) from a modest, 3.4-day pilot survey with the Australian Square Kilometre Array Pathfinder. The survey was conducted in a wide-field fly’s-eye configuration using the phased-array-feed technology deployed on the array to instantaneously observe an effective area of 160 deg2, and achieve an exposure totaling 13200 deg2 hr . We constrain the position of FRB 170107 to a region 8\\prime × 8\\prime in size (90% containment) and its fluence to be 58 ± 6 Jy ms. The spectrum of the burst shows a sharp cutoff above 1400 MHz, which could be due to either scintillation or an intrinsic feature of the burst. This confirms the existence of an ultra-bright (> 20 Jy ms) population of FRBs.

Chapter 27: Deja vu All Over Again: Using NVO Tools to Re-Investigate a Complete Sample of Texas Radio Survey Sources

NASA Astrophysics Data System (ADS)

Lucas, Ray A.; Rohde, David; Tamura, Takayuki; van Dyne, Jeffrey

At the first NVO Summer School in September 2004, a complete sample of Texas Radio Survey sources, first derived in 1989 and subsequently observed with the VLA in A-array snapshot mode in 1990, was revisited. The original investigators had never had the occasion to reduce the A-array 5-minute snapshot data, nor to do any other significant follow-up, though the sample still seemed a possibly useful but relatively small study of radio galaxies, AGN, quasars, extragalactic sources, and galaxy clusters, etc. At the time of the original sample definition in late 1989, the best optical material available for the region was the SRC-J plate from the UK Schmidt Telescope in Australia. In much more recent times, the Sloan Digital Sky Survey has included the region in its DR2 data release, so good multicolor optical imaging in a number of standard bandpasses has finally become available. These data, along with other material in the radio, infrared, and (where available) were used to get a better preliminary idea of the nature of the objects in the 1989 sample. We also investigated one of the original questions: whether these radio sources with steeper (or at least non-flat) radio spectra were associated with galaxy clusters, and in some cases higher-redshift galaxy clusters and AGN. A rudimentary web service was created which allowed the user to perform simple cone searches and SIAP image extractions of specified field sizes for multiwavelength data across the electromagnetic spectrum, and a prototype web page was set up which would display the resulting images in wavelength order across the page for sources in the sample. Finally, as an additional investigation, using radio and X-ray IDs as a proxy for AGN which might be associated with large, central cluster galaxies, positional matches of radio and X-ray sources from two much larger catalogs were done using the tool TOPCAT in order to search for the degree of correlation between ID positions, radio luminosity, and cluster ID positions. It was hoped that cross-correlated matches could possibly give some clue to the relationship of these radio sources to galaxy clusters. These preliminary results need more in-depth investigation and are currently being pursued via a NVO grant to the first author. The original VLA 5-minute A-array snapshots have also now been reduced and are complementary in nature to the VLA FIRST data. It is planned to eventually make these reduced VLA A-array data publicas part of a web service via the NVO facilities along with a table of multiwavelength properties for the sources in VOTable format.

77. ARAII. Room at northeast corner of ARA606 used for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

77. ARA-II. Room at northeast corner of ARA-606 used for welding training and welding procedure qualification and performance testing. This was only building in use at ARA-II by 1983. Date: 1983. Ineel photo no. 83-476-3-5. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

138. ARAII Building ARA606 floor plan for remodel as Inel ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

138. ARA-II Building ARA-606 floor plan for remodel as Inel Welding Laboratory. Shows room divisions and welding stations to be installed. Aerojet Nuclear Company 1375-ARA-II-606-E-2. Date: June 1976. Ineel index code no. 070-0606-10-400-156552. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

MITLL 2015 Language Recognition Evaluation System Description

DTIC Science & Technology

2016-01-27

912 8.18 qsl-rus Russian 2021 37.80 ara-ary Maghrebi 919 46.91 spa-car Carib. Spa. 194 30.59 ara-arz Egyptian 440 97.27 spa-eur Eur. Spa. 366 8.55...qsl-pol Polish 695 32.14 ara-arb MSA 912 8.18 qsl-rus Russian 2021 37.80 ara-ary Maghrebi 919 46.91 spa-car Carib. Spa. 194 30.59 ara-arz Egyptian ...BOTTLENECK I-VECTOR SYSTEM (BNF1) The Deep Neural Network architecture that we used for this system was composed of seven hidden layers. The sixth

The Gamma-Ray Emitting Radio-Loud Narrow-Line Seyfert 1 Galaxy PKS 2004-447 II. The Radio View

NASA Technical Reports Server (NTRS)

Schulz, R.; Kreikenbohm, A.; Kadler, M.; Ojha, R.; Ros, E.; Stevens, J.; Edwards, P. G.; Carpenter, B.; Elsaesser, D.; Gehrels, N.;

The double quasar 0957+561: a radio study at 6-centimeters wavelength.

PubMed

Roberts, D H; Greenfield, P E; Burke, B F

1979-08-31

The optical double quasar 0957+561 has been interpreted as the gravitational double image of a single object. A radio map made with the Very Large Array of the National Radio Astronomy Observatory shows unresolved sources coincident With the optical images as well as a complex of related extended emission. Although the results cannot rule out the gravitational lens hypothesis, the complex radio structure is more easily interpreted as two separate quasars. The optical and radio properties of the two quasars are so similar that the two must have been formed at the same time with similar initial conditions.

Exoplanet-induced Radio Emission from M Dwarfs

NASA Astrophysics Data System (ADS)

Turnpenney, Sam; Nichols, Jonathan D.; Wynn, Graham A.; Burleigh, Matthew R.

2018-02-01

We consider the magnetic interaction of exoplanets orbiting M dwarfs, calculating the expected Poynting flux carried upstream along Alfvén wings to the central star. A region of emission analogous to the Io footprint observed in Jupiter’s aurora is produced, and we calculate the radio flux density generated near the surface of the star via the electron-cyclotron maser instability. We apply the model to produce individual case studies for the TRAPPIST-1, Proxima Centauri, and dwarf NGTS-1 systems. We predict steady-state flux densities of up to ∼10 μJy and sporadic bursts of emission of up to ∼1 mJy from each case study, suggesting these systems may be detectable with the Very Large Array and the Giant Metrewave Radio Telescope, and perhaps the Square Kilometre Array in the future. Finally, we present a survey of 85 exoplanets orbiting M dwarfs, identifying 11 such objects capable of generating radio emission above 10 μJy.

The Gould's Belt Very Large Array Survey. II. The Serpens Region

NASA Astrophysics Data System (ADS)

Ortiz-León, Gisela N.; Loinard, Laurent; Mioduszewski, Amy J.; Dzib, Sergio A.; Rodríguez, Luis F.; Pech, Gerardo; Rivera, Juana L.; Torres, Rosa M.; Boden, Andrew F.; Hartmann, Lee; Evans, Neal J., II; Briceño, Cesar; Tobin, John; Kounkel, Marina A.; González-Lópezlira, Rosa A.

2015-05-01

We present deep (∼17 μJy) radio continuum observations of the Serpens molecular cloud, the Serpens south cluster, and the W40 region obtained using the Very Large Array in its A configuration. We detect a total of 146 sources, 29 of which are young stellar objects (YSOs), 2 of which are BV stars, and 5 more of which are associated with phenomena related to YSOs. Based on their radio variability and spectral index, we propose that about 16 of the remaining 110 unclassified sources are also YSOs. For approximately 65% of the known YSOs detected here as radio sources, the emission is most likely non-thermal and related to stellar coronal activity. As also recently observed in Ophiuchus, our sample of YSOs with X-ray counterparts lies below the fiducial Güdel & Benz relation. Finally, we analyze the proper motions of nine sources in the W40 region. This allows us to better constrain the membership of the radio sources in the region.

Foreground Characterization for the Murchison Widefield Array Using the Jansky Very Large Array

NASA Astrophysics Data System (ADS)

Busch, Michael P.; Bowman, Judd D.; Kittiwisit, Piyanat; Jacobs, Danny

2016-01-01

One of the most compelling questions in astrophysics today is how the process of galaxy formation unfolded during the Epoch of Reionization (EoR). A new generation of radio telescopes, including the Murchison Widefield Array (MWA) and others, are attempting to capture the redshifted 21cm signal from neutral hydrogen during the EoR. Mapping the reionization of the intergalactic medium (IGM) is one of the core objectives of 21 cm observatories. A pressing concern of these observations is the bright foreground sources in the telescope's sidelobes outside the primary beam of the MWA. These sources, including AGN, radio galaxies and local Galactic sources, are numerous and difficult to deal with. These foreground contaminants are five orders of magnitude brighter than the redshifted 21 cm emission expected from the IGM during the EoR. The Jansky Very Large Array (JVLA) in New Mexico can provide sensitive characterization of these sources in the MWA's northern sidelobe. We observed 100 bright radio sources using the JVLA in P-band and characterized these sources by extracting the spectral fits and fluxes for each source. By creating a foreground model for these data, the MWA will be able to better subtract these sources from future EoR measurements. We report the current status of the creation of the foreground model.

Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury?

PubMed

Mann, Aniv; Cohen-Yeshurun, Ayelet; Trembovler, Victoria; Mechoulam, Raphael; Shohami, Esther

2016-05-01

In recent years, a library of approx. 70 N-acyl aminoacids (NAAAs) was discovered in the rat brain. A particular member of this family of compounds is arachidonoyl serine (AraS), which has generated special interest as a potential therapy for traumatic brain injury (TBI). This is due to its structural similarity to the endocannabinoid (eCB) 2-arachidonoyl glycerol (2-AG), which was previously shown to be beneficial in the recovery in a closed head injury model of TBI. Indeed, AraS exerted eCB-mediated neuroprotection, which was evident in numerous aspects related to the secondary damage characterizing TBI. These findings promoted broadening of the research to additional compounds of the NAAA family that share a structural similarity to AraS, namely, palmitoyl serine (PalmS) and oleoyl serine. The latter did not exhibit any improvement in recovery, whereas the former displayed some neuroprotection, albeit inferior to 2-AG and AraS, via unknown mechanisms. Interestingly, when a combined treatment of 2-AG, AraS and PalmS was tested, the overall effect on the severity score was inferior to their individual effects, suggesting not only a lack of direct or indirect synergism, but also possibly some spatial hindrance. Taken together, the complexity of the damage caused by TBI and the many open questions concerning the role of the eCB system in health and disease, the findings so far may serve as a small trace to the understanding of the eCB system, as well as of the mechanisms underlying TBI.

Bilateral uveitis and hyphema in a Catalina Macaw (Ara ararauna x Ara macao) associated with multicentric lymphoma

USDA-ARS?s Scientific Manuscript database

A 20-year-old, female Catalina macaw (Ara ararauna × Ara macao) was presented with bilateral uveitis and hyphema. The hyphema initially improved with 0.12% prednisolone acetate ophthalmic drops (1 drop OU q4h for 7 days), but the hyphema recurred after the drops were tapered. The bird subsequently d...

110. ARAI support facilities. Index of drawings related to initial ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

110. ARA-I support facilities. Index of drawings related to initial construction of hot cell building ARA-626, shop and maintenance building ARA-627, and other buildings at ARA-I. Date: Circa January 1959. Norman Engineering Company. Ineel index code no. 068-9999-80-613-102703. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

137. ARAII Building ARA602 floor plan as it appeared in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

137. ARA-II Building ARA-602 floor plan as it appeared in 1980 when electrical modifications were being made. Shows partial layout of floor plan. EG&G Idaho, Inc. 1570-ARA-II-602-E-3. Date: April 1980. Ineel index code no. 070--0602-10-220-159761. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

125. ARAI Contaminated waste storage tank (ARA729). Shows location of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

125. ARA-I Contaminated waste storage tank (ARA-729). Shows location of tank on the ARA-I site, section views, connecting pipeline, and other details. Norman Engineering Company 961-area/SF-301-3. Date: January 1959. Ineel index code no. 068-0301-00-613-102711. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Boiling and Frying Peanuts Decreases Soluble Peanut (Arachis Hypogaea) Allergens Ara h 1 and Ara h 2 But Does Not Generate Hypoallergenic Peanuts

PubMed Central

Comstock, Sarah S.; Maleki, Soheila J.; Teuber, Suzanne S.

2016-01-01

Peanut allergy continues to be a problem in most developed countries of the world. We sought a processing method that would alter allergenic peanut proteins, such that allergen recognition by IgE from allergic individuals would be significantly reduced or eliminated. Such a method would render accidental exposures to trace amounts of peanuts safer. A combination of boiling and frying decreased recovery of Ara h 1 and Ara h 2 at their expected MWs. In contrast, treatment with high pressures under varying temperatures had no effect on protein extraction profiles. Antibodies specific for Ara h 1, Ara h 2, and Ara h 6 bound proteins extracted from raw samples but not in boiled/fried samples. However, pre-incubation of serum with boiled/fried extract removed most raw peanut-reactive IgE from solution, including IgE directed to Ara h 1 and 2. Thus, this method of processing is unlikely to generate a peanut product tolerated by peanut allergic patients. Importantly, variability in individual patients’ IgE repertoires may mean that some patients’ IgE would bind fewer polypeptides in the sequentially processed seed. PMID:27310538

GPS-Like Phasing Control of the Space Solar Power System Transmission Array

NASA Technical Reports Server (NTRS)

Psiaki, Mark L.

2003-01-01

The problem of phasing of the Space Solar Power System's transmission array has been addressed by developing a GPS-like radio navigation system. The goal of this system is to provide power transmission phasing control for each node of the array that causes the power signals to add constructively at the ground reception station. The phasing control system operates in a distributed manner, which makes it practical to implement. A leader node and two radio navigation beacons are used to control the power transmission phasing of multiple follower nodes. The necessary one-way communications to the follower nodes are implemented using the RF beacon signals. The phasing control system uses differential carrier phase relative navigation/timing techniques. A special feature of the system is an integer ambiguity resolution procedure that periodically resolves carrier phase cycle count ambiguities via encoding of pseudo-random number codes on the power transmission signals. The system is capable of achieving phasing accuracies on the order of 3 mm down to 0.4 mm depending on whether the radio navigation beacons operate in the L or C bands.

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

DOE PAGES

Aab, Alexander

2016-06-14

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy density is determined from the radio pulses at each observer position and is interpolated using a two dimensional functionmore » that takes into account signal asymmetries due to interference between the geomagnetic and charge excess emission components. We found that the spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy – corrected for geometrical effects – is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. Finally we find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.« less

Thunderstorm observations by air-shower radio antenna arrays

NASA Astrophysics Data System (ADS)

Apel, W. D.; Arteaga, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Ender, M.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Nehls, S.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F. G.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2011-10-01

Relativistic, charged particles present in extensive air showers (EAS) lead to a coherent emission of radio pulses which are measured to identify the shower initiating high-energy cosmic rays. Especially during thunderstorms, there are additional strong electric fields in the atmosphere, which can lead to further multiplication and acceleration of the charged particles and thus have influence on the form and strength of the radio emission. For a reliable energy reconstruction of the primary cosmic ray by means of the measured radio signal it is very important to understand how electric fields affect the radio emission. In addition, lightning strikes are a prominent source of broadband radio emissions that are visible over very long distances. This, on the one hand, causes difficulties in the detection of the much lower signal of the air shower. On the other hand the recorded signals can be used to study features of the lightning development. The detection of cosmic rays via the radio emission and the influence of strong electric fields on this detection technique is investigated with the LOPES experiment in Karlsruhe, Germany. The important question if a lightning is initiated by the high electron density given at the maximum of a high-energy cosmic-ray air shower is also investigated, but could not be answered by LOPES. But, these investigations exhibit the capabilities of EAS radio antenna arrays for lightning studies. We report about the studies of LOPES measured radio signals of air showers taken during thunderstorms and give a short outlook to new measurements dedicated to search for correlations of lightning and cosmic rays.

Tracking Solar Type II Bursts with Space Based Radio Interferometers

NASA Astrophysics Data System (ADS)

Hegedus, Alexander M.; Kasper, Justin C.; Manchester, Ward B.

2018-06-01

The Earth’s Ionosphere limits radio measurements on its surface, blocking out any radiation below 10 MHz. Valuable insight into many astrophysical processes could be gained by having a radio interferometer in space to image the low frequency window for the first time. One application is observing type II bursts tracking solar energetic particle acceleration in Coronal Mass Ejections (CMEs). In this work we create a simulated data processing pipeline for several space based radio interferometer (SBRI) concepts and evaluate their performance in the task of localizing these type II bursts.Traditional radio astronomy software is hard coded to assume an Earth based array. To circumvent this, we manually calculate the antenna separations and insert them along with the simulated visibilities into a CASA MS file for analysis. To create the realest possible virtual input data, we take a 2-temperature MHD simulation of a CME event, superimpose realistic radio emission models from the CME-driven shock front, and propagate the signal through simulated SBRIs. We consider both probabilistic emission models derived from plasma parameters correlated with type II bursts, and analytical emission models using plasma emission wave interaction theory.One proposed SBRI is the pathfinder mission SunRISE, a 6 CubeSat interferometer to circle the Earth in a GEO graveyard orbit. We test simulated trajectories of SunRISE and image what the array recovers, comparing it to the virtual input. An interferometer on the lunar surface would be a stable alternative that avoids noise sources that affect orbiting arrays, namely the phase noise from positional uncertainty and atmospheric 10s-100s kHz noise. Using Digital Elevation Models from laser altimeter data, we test different sets of locations on the lunar surface to find near optimal configurations for tracking type II bursts far from the sun. Custom software is used to model the response of different array configurations over the lunar year, combining ephemerides of the sun and moon to correlate the virtual data. We analyze the pros and cons of all approaches and offer recommendations for SRBIs that track type II bursts.

Radio SETI Observations of the Anomalous Star KIC 8462852

NASA Astrophysics Data System (ADS)

Harp, G. R.; Richards, Jon; Shostak, Seth; Tarter, J. C.; Vakoch, Douglas A.; Munson, Chris

2016-07-01

We report on a search for the presence of signals from extraterrestrial intelligence in the direction of the star system KIC 8462852. Observations were made at radio frequencies between 1 and 10 GHz using the Allen Telescope Array. No narrowband radio signals were found at a level of 180-300 Jy in a 1 Hz channel, or medium band signals above 10 Jy in a 100 kHz channel.

Mystery solved: discovery of extended radio emission in the merging galaxy cluster Abell 2146

NASA Astrophysics Data System (ADS)

Hlavacek-Larrondo, J.; Gendron-Marsolais, M.-L.; Fecteau-Beaucage, D.; van Weeren, R. J.; Russell, H. R.; Edge, A.; Olamaie, M.; Rumsey, C.; King, L.; Fabian, A. C.; McNamara, B.; Hogan, M.; Mezcua, M.; Taylor, G.

2018-04-01

Abell 2146 (z = 0.232) is a massive galaxy cluster currently undergoing a spectacular merger in the plane of the sky with a bullet-like morphology. It was the first system in which both the bow and upstream shock fronts were detected at X-ray wavelengths (Mach ˜2), yet deep Giant MetreWave Telescope 325 MHz observations failed to detect extended radio emission associated with the cluster as is typically seen in such systems. We present new, multiconfiguration 1-2 GHz Karl G. Jansky Very Large Array (VLA) observations of Abell 2146 totalling 16 h of observations. These data reveal for the first time the presence of an extended (≈850 kpc), faint radio structure associated with Abell 2146. The structure appears to harbour multiple components, one associated with the upstream shock that we classify as a radio relic and one associated with the subcluster core that is consisted as being a radio halo bounded by the bow shock. The newly detected structures have some of the lowest radio powers detected thus far in any cluster (P1.4 GHz, halo = 2.4 ± 0.2 × 1023 W Hz-1 and P1.4 GHz, relic = 2.2 ± 0.2 × 1023 W Hz-1). The flux measurement of the halo, as well as its morphology, also suggests that the halo was recently created (≈0.3 Gyr after core passage), consistent with the dynamical state of the cluster. These observations demonstrate the capacity of the upgraded VLA to detect extremely faint and extended radio structures. Based on these observations, we predict that many more radio relics and radio haloes in merging clusters should be detected by future radio facilities such as the Square Kilometre Array.

Extreme Millimeter/Sub-millimeter and Radio Flares from V404 Cyg (GS 2023+338)

NASA Astrophysics Data System (ADS)

Tetarenko, A.; Sivakoff, G. R.; Young, Ken; Wouterloot, J. G. A.; Miller-Jones, J. C.

2015-06-01

We report follow up radio and mm/sub-mm observations (ATel #7671) of the current outburst of the black hole X-ray binary, V404 Cyg, with the VLA, Submillimeter Array (SMA), and James Clerk Maxwell Telescope SCUBA-2 (JCMT).

Costs Associated with Anesthesia-Related Adverse Events During Labor and Delivery in New York State, 2010.

PubMed

Hunt, Tristan D; Guglielminotti, Jean; Li, Guohua

2016-06-01

The safety of anesthetic care provided during childbirth has improved during the past 2 decades in the United States, with a marked decrease in the rate of anesthesia-related adverse events (ARAEs). To date, there is little research on the costs of ARAEs in obstetrics. This study aims to assess the excess cost and cost per admission associated with ARAEs during labor and delivery. Data came from the New York State Inpatient Database 2010. Discharge records indicating labor and delivery and ARAEs were identified with International Classification of Diseases, Ninth Revision, Clinical Modification codes. ARAEs were defined as minor if not associated with maternal death, cardiac arrest, or severe morbidity. Costs were calculated as the product of hospital charges and the group average all-payer inpatient charge-to-cost conversion ratio. Excess cost was calculated as the difference between the mean cost of discharges with and without ARAEs. The cost per admission was calculated as the product of the excess cost and ARAE incidence. Excess costs and cost per admission were also calculated for 2 pregnancy-related complications: postpartum hemorrhage and preeclampsia/eclampsia. There were 228,104 delivery-related discharges in the study; of these, 1053 recorded at least 1 ARAE (4.6 per 1000), with 1034 (98.2%) of the ARAEs being minor. The adjusted excess cost associated with ARAEs was $1189 (95% confidence interval [CI], 1033-1350) and the cost per admission $5.49 (95% CI, 4.77-6.23). The incidence of postpartum hemorrhage and preeclamspia/eclampsia was 25.1 and 43.8 per 1000, respectively. The adjusted excess cost was $679 (95% CI, 608-748) and $1328 (95% CI, 1272-1378), respectively; the cost per admission was $17.07 (95% CI, 15.27-18.81) and $58.16 (95% CI, 55.72-60.34), respectively. ARAEs during labor and delivery are associated with significant excess cost. However, the excess cost per admission for ARAEs is significantly less compared with the excess cost per admission for preeclampsia/eclampsia and postpartum hemorrhage.

Effect of Heating and Glycation on the Allergenicity of 2S Albumins (Ara h 2/6) from Peanut

PubMed Central

Skov, Per Stahl; Johnson, Phil E.; Rigby, Neil M.; Przybylski-Nicaise, Laetitia; Bernard, Hervé; Wal, Jean-Michel; Ballmer-Weber, Barbara; Zuidmeer-Jongejan, Laurian; Szépfalusi, Zsolt; Ruinemans-Koerts, Janneke; Jansen, Ad P. H.; Savelkoul, Huub F. J.; Wichers, Harry J.; Mackie, Alan R.; Mills, Clare E. N.; Adel-Patient, Karine

2011-01-01

Background Peanut allergy is one of the most common and severe food allergies, and processing is known to influence the allergenicity of peanut proteins. We aimed to establish the effect of heating and glycation on the IgE-binding properties and biological activity of 2S albumins (Ara h 2/6) from peanut. Methodology/Principal Findings Native Ara h 2/6 was purified from raw peanuts and heated in solution (15 min, 110°C) in the presence or absence of glucose. Ara h 2 and 6 were also purified from roasted peanut. Using PBMC and sera from peanut-allergic patients, the cellular proliferative potency and IgE reactivity (reverse EAST inhibition) and functionality (basophil degranulation capacity) of allergens were assessed. Heating Ara h 2/6 at 110°C resulted in extensive denaturation, hydrolysis and aggregation of the protein, whilst Ara h 2 and 6 isolated from roasted peanut retained its native conformation. Allergen stimulation of PBMC induced proliferation and Th2 cytokine secretion which was unaffected by thermal processing. Conversely, IgE reactivity and functionality of Ara h 2/6 was decreased by heating. Whilst heating-glycation further reduced the IgE binding capacity of the proteins, it moderated their loss of histamine releasing capacity. Ara h 2 and 6 purified from roasted peanut demonstrated the same IgE reactivity as unheated, native Ara h 2/6. Conclusions/Significance Although no effect of processing on T-cell reactivity was observed, heat induced denaturation reduced the IgE reactivity and subsequent functionality of Ara h 2/6. Conversely, Ara h 2 and 6 purified from roasted peanut retained the structure and IgE reactivity/functionality of the native protein which may explain the allergenic potency of this protein. Through detailed molecular study and allergenicity assessment approaches, this work then gives new insights into the effect of thermal processing on structure/allergenicity of peanut proteins. PMID:21901150

Effects of Arachidonic Acid Supplementation on Acute Anabolic Signaling and Chronic Functional Performance and Body Composition Adaptations.

PubMed

De Souza, Eduardo O; Lowery, Ryan P; Wilson, Jacob M; Sharp, Matthew H; Mobley, Christopher Brooks; Fox, Carlton D; Lopez, Hector L; Shields, Kevin A; Rauch, Jacob T; Healy, James C; Thompson, Richard M; Ormes, Jacob A; Joy, Jordan M; Roberts, Michael D

2016-01-01

The primary purpose of this investigation was to examine the effects of arachidonic acid (ARA) supplementation on functional performance and body composition in trained males. In addition, we performed a secondary study looking at molecular responses of ARA supplementation following an acute exercise bout in rodents. Thirty strength-trained males (age: 20.4 ± 2.1 yrs) were randomly divided into two groups: ARA or placebo (i.e. CTL). Then, both groups underwent an 8-week, 3-day per week, non-periodized training protocol. Quadriceps muscle thickness, whole-body composition scan (DEXA), muscle strength, and power were assessed at baseline and post-test. In the rodent model, male Wistar rats (~250 g, ~8 weeks old) were pre-fed with either ARA or water (CTL) for 8 days and were fed the final dose of ARA prior to being acutely strength trained via electrical stimulation on unilateral plantar flexions. A mixed muscle sample was removed from the exercised and non-exercised leg 3 hours post-exercise. Lean body mass (2.9%, p<0.0005), upper-body strength (8.7%, p<0.0001), and peak power (12.7%, p<0.0001) increased only in the ARA group. For the animal trial, GSK-β (Ser9) phosphorylation (p<0.001) independent of exercise and AMPK phosphorylation after exercise (p-AMPK less in ARA, p = 0.041) were different in ARA-fed versus CTL rats. Our findings suggest that ARA supplementation can positively augment strength-training induced adaptations in resistance-trained males. However, chronic studies at the molecular level are required to further elucidate how ARA combined with strength training affect muscle adaptation.

Directions for Space-Based Low-Frequency Radio Astronomy 2. Telescopes

NASA Astrophysics Data System (ADS)

Basart, J. P.; Burns, J. O.; Dennison, B. K.; Weiler, K. W.; Kassim, N. E.; Castillo, S. P.; McCune, B. M.

Astronomical studies of celestial sources at low radio frequencies (0.3 to 30 MHz) lag far behind the investigations of celestial sources at high radio frequencies. In a companion paper [Basart et al., this issue] we discussed the need for low-frequency investigations, and in this paper we discuss the telescopes required to make the observations. Radio telescopes for use in the low-frequency range can be built principally from ``off-the-shelf'' components. For relatively little cost for a space mission, great strides can be made in deploying arrays of antennas and receivers in space that would produce data contributing significantly to our understanding of galaxies and galactic nebulae. In this paper we discuss an evolutionary sequence of telescopes, antenna systems, receivers, and (u,v) plane coverage. The telescopes are space-based because of the disruptive aspects of the Earth's ionosphere on low-frequency celestial signals traveling to the Earth's surface. Orbiting antennas consisting of array elements deposited on a Kevlar balloon have strong advantages of nearly identical multiple beams over 4π steradians and few mechanical aspects in deployment and operation. The relatively narrow beam width of these antennas can significantly help reduce the ``confusion'' problem. The evolutionary sequence of telescopes starts with an Earth-orbiting spectrometer to measure the low-frequency radio environment in space, proceeds to a two-element interferometer, then to an orbiting array, and ends with a telescope on the lunar farside. The sequence is in the order of increasing capability which is also the order of increasing complexity and cost. All the missions can be accomplished with current technology.

A Multi-Frequency Study of the Milky Way-Like Spiral Galaxy NGC 6744

NASA Astrophysics Data System (ADS)

Yew, Miranda; Filipović, Miroslav D.; Roper, Quentin; Collier, Jordan D.; Crawford, Evan J.; Jarrett, Thomas H.; Tothill, Nicholas F. H.; O'Brien, Andrew N.; Pavlović, Marko Z.; Pannuti, Thomas G.; Galvin, Timothy J.; Kapińska, Anna D.; Cluver, Michelle E.; Banfield, Julie K.; Schlegel, Eric M.; Maxted, Nigel; Grieve, Kevin R.

2018-03-01

We present a multi-frequency study of the intermediate spiral SAB(r)bc type galaxy NGC 6744, using available data from the Chandra X-Ray telescope, radio continuum data from the Australia Telescope Compact Array and Murchison Widefield Array, and Wide-field Infrared Survey Explorer infrared observations. We identify 117 X-ray sources and 280 radio sources. Of these, we find nine sources in common between the X-ray and radio catalogues, one of which is a faint central black hole with a bolometric radio luminosity similar to the Milky Way's central black hole. We classify 5 objects as supernova remnant (SNR) candidates, 2 objects as likely SNRs, 17 as H ii regions, 1 source as an AGN; the remaining 255 radio sources are categorised as background objects and one X-ray source is classified as a foreground star. We find the star-formation rate (SFR) of NGC 6744 to be in the range 2.8-4.7 M⊙ yr - 1 signifying the galaxy is still actively forming stars. The specific SFR of NGC 6744 is greater than that of late-type spirals such as the Milky Way, but considerably less that that of a typical starburst galaxy.

Development of a Multi-frequency Interferometer Telescope for Radio Astronomy (MITRA)

NASA Astrophysics Data System (ADS)

Ingala, Dominique Guelord Kumamputu

2015-03-01

This dissertation describes the development and construction of the Multi-frequency Interferometer Telescope for Radio Astronomy (MITRA) at the Durban University of Technology. The MITRA station consists of 2 antenna arrays separated by a baseline distance of 8 m. Each array consists of 8 Log-Periodic Dipole Antennas (LPDAs) operating from 200 MHz to 800 MHz. The design and construction of the LPDA antenna and receiver system is described. The receiver topology provides an equivalent noise temperature of 113.1 K and 55.1 dB of gain. The Intermediate Frequency (IF) stage was designed to produce a fixed IF frequency of 800 MHz. The digital Back-End and correlator were implemented using a low cost Software Defined Radio (SDR) platform and Gnu-Radio software. Gnu-Octave was used for data analysis to generate the relevant received signal parameters including total power, real, and imaginary, magnitude and phase components. Measured results show that interference fringes were successfully detected within the bandwidth of the receiver using a Radio Frequency (RF) generator as a simulated source. This research was presented at the IEEE Africon 2013 / URSI Session Mauritius, and published in the proceedings.

Antenna design and implementation for the future space Ultra-Long wavelength radio telescope

NASA Astrophysics Data System (ADS)

Chen, Linjie; Aminaei, Amin; Gurvits, Leonid I.; Wolt, Marc Klein; Pourshaghaghi, Hamid Reza; Yan, Yihua; Falcke, Heino

2018-04-01

In radio astronomy, the Ultra-Long Wavelengths (ULW) regime of longer than 10 m (frequencies below 30 MHz), remains the last virtually unexplored window of the celestial electromagnetic spectrum. The strength of the science case for extending radio astronomy into the ULW window is growing. However, the opaqueness of the Earth's ionosphere makes ULW observations by ground-based facilities practically impossible. Furthermore, the ULW spectrum is full of anthropogenic radio frequency interference (RFI). The only radical solution for both problems is in placing an ULW astronomy facility in space. We present a concept of a key element of a space-borne ULW array facility, an antenna that addresses radio astronomical specifications. A tripole-type antenna and amplifier are analysed as a solution for ULW implementation. A receiver system with a low power dissipation is discussed as well. The active antenna is optimized to operate at the noise level defined by the celestial emission in the frequency band 1 - 30 MHz. Field experiments with a prototype tripole antenna enabled estimates of the system noise temperature. They indicated that the proposed concept meets the requirements of a space-borne ULW array facility.

LOPES — Recent Results and Open Questions on the Radio Detection of Air Showers

NASA Astrophysics Data System (ADS)

Schröder, F. G.; Apel, W. D.; Arteaga-Velázquez, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Fuchs, B.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schoo, S.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Zabierowski, J.; Zensus, J. A.

2015-08-01

LOPES was a digital antenna array operating for approximately 10 years until spring 2013 at the Karlsruhe Institute of Technology (KIT). Triggered by the co-located KASCADE-Grande air-shower experiment, it measured the radio signal of around 1000 cosmic-ray air showers with energies E ≳ 1017 eV in an effective band of 43 - 74 MHz. Using the interferometric technique of cross-correlation beamforming, LOPES could reconstruct the shower direction with an accuracy < 0.7°, the shower energy with a precision < 20%, and the atmospheric depth of the shower maximum, Xmax, with a precision < 95g/cm2. In particular the reconstruction of the shower maximum suffers from significant measurement uncertainties due to the radio-loud environment of the site. This article summarizes our latest results on the reconstruction of the shower maximum, using two independent methods: the steepness of the hyperbolic radio wavefront and the slope of the lateral distribution of the radio amplitude. Moreover, we show vectorial measurements of the electric field with the tripole antennas of the latest LOPES setup. Finally, we discuss open questions as well as the potential impact of the lessons learned at LOPES for future antenna arrays.

Solving the corner-turning problem for large interferometers

NASA Astrophysics Data System (ADS)

Lutomirski, Andrew; Tegmark, Max; Sanchez, Nevada J.; Stein, Leo C.; Urry, W. Lynn; Zaldarriaga, Matias

2011-01-01

The so-called corner-turning problem is a major bottleneck for radio telescopes with large numbers of antennas. The problem is essentially that of rapidly transposing a matrix that is too large to store on one single device; in radio interferometry, it occurs because data from each antenna need to be routed to an array of processors each of which will handle a limited portion of the data (say, a frequency range) but requires input from each antenna. We present a low-cost solution allowing the correlator to transpose its data in real time, without contending for bandwidth, via a butterfly network requiring neither additional RAM memory nor expensive general-purpose switching hardware. We discuss possible implementations of this using FPGA, CMOS, analog logic and optical technology, and conclude that the corner-turner cost can be small even for upcoming massive radio arrays.

Early docosahexaenoic and arachidonic acid supplementation in extremely-low-birth-weight infants.

PubMed

Robinson, Daniel T; Caplan, Michael; Carlson, Susan E; Yoder, Rachel; Murthy, Karna; Frost, Brandy

2016-10-01

Extremely-low-birth-weight (ELBW) infants accrue large deficits in docosahexaenoic acid (DHA) and arachidonic acid (ARA) and require improved supplementation strategies. We hypothesized that once daily DHA+ARA drops applied to buccal mucosa will increase blood levels. Thirty ELBW infants were randomized to receive DHA 20 mg/kg/d + ARA 40 or 60 mg/kg/d + ARA 120 mg/kg/d or placebo within 72 h of age for 8 wk duration. Red blood cell phospholipid levels of DHA (primary) and ARA (secondary) were measured at 2 and 8 wk of age. Twenty-eight survivors with a median birth weight of 806 g completed dosing and sampling. Red blood cell levels were similar between the three groups at 2 wk (DHA: 4.62 wt% (interquartile range (IQR) 4.1-5.5) for all, P = 0.29 between groups; ARA: 21.1 wt% (IQR 18.78-22.6) for all, P = 0.41 between groups) and 8 wk (DHA: 6.0 wt% (IQR 5.1-7.1) for all, P = 0.57 between groups; ARA: 20.1 wt% (IQR 18.3-23.1) for all, P = 0.63 between groups). DHA in all infants showed a median increase of 31% from 2 to 8 wk (P < 0.04). ARA levels did not significantly change over time (P > 0.6). Daily buccal DHA and ARA supplements did not affect fatty acid levels in ELBW infants.

South African Student Constructed Indlebe Radio Telescope

NASA Astrophysics Data System (ADS)

McGruder, Charles H.; MacPherson, Stuart; Janse Van Vuuren, Gary Peter

2017-01-01

The Indlebe Radio Telescope (IRT) is a small transit telescope with a 5 m diameter parabolic reflector working at 21 cm. It was completely constructed by South African (SA) students from the Durban University of Technology (DUT), where it is located. First light occurred on 28 July 2008, when the galactic center, Sagittarius A, was detected. As a contribution to the International Year of Astronomy in 2009, staff members in the Department of Electronic Engineering at DUT in 2006 decided to have their students create a fully functional radio telescope by 2009. The specific project aims are to provide a visible project that could generate interest in science and technology in high school students and to provide a real world system for research in radio astronomy in general and an optimization of low noise radio frequency receiver systems in particular. These aims must be understood in terms of the SA’s government interests in radio astronomy. SA is a partner in the Square Kilometer Array (SKA) project, has constructed the Karoo Array Telescope (KAT) and MeerKat, which is the largest and most sensitive radio telescope in the southern hemisphere. SA and its partners in Africa are investing in the construction of the African Very Long Baseline Interferometry Network (AVN), an array of radio telescopes throughout Africa as an extension of the existing global Very Long Baseline Interferometry Network (VLBI). These projects will allow SA to make significant contributions to astronomy and enable astronomy to contribute to the scientific education and development goals of the country. The IRT sees on a daily basis the transit of Sag A. The transit time is influenced by precession, nutation, polar motion, aberration, celestial pole offset, proper motion, length of the terrestrial day and variable ionospheric refraction. Of these eight factors six are either predictable or measureable. To date neither celestial pole offset nor variable ionospheric refraction are predicable. Currently, we are comparing the observed transit times of Sag A with the calculable predications in order to obtain information over these two factors, with a view to better understanding them.

Nobeyama Radio Observatory

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

Nobeyama Radio Observatory has telescopes at millimeter and submillimeter wavelengths. It was established in 1982 as an observatory of Tokyo Astronomical Observatory (NATIONAL ASTRONOMICAL OBSERVATORY, JAPAN since 1987), and operates the 45 m telescope, Nobeyama Millimeter Array, and Radioheliograph. High-resolution images of star forming regions and molecular clouds have revealed many aspects of...

NHPP for FRBs, Version 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawrence, Earl; Wiel, Scott Vander

This code implements the non-homogeneous poisson process model for estimating the rate of fast radio bursts. It includes modeling terms for the distribution of events in the Universe and the detection sensitivity of the radio telescopes and arrays used in observation. The model is described in LA-UR-16-26261.

130. ARAII Administration building (ARA613) vicinity map and plot plan ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

130. ARA-II Administration building (ARA-613) vicinity map and plot plan showing relationship to other existing buildings on site and to ARA-602, to which this building was attached. F.C. Torkelson Comapny 842-area/SL-1-101-U-1. Date: October 1959. Ineel index code no. 070-0101-65-851-150053. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

120. ARAI Expansion of ARA627 shop and maintenance building for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

120. ARA-I Expansion of ARA-627 shop and maintenance building for new use as materials and metallurgy laboratory. Shows ground floor plan addition of gas analyzer room, fatigue testing room, microscope room, and offices. Idaho Nuclear Corporation 1230-ARA-627-A-5. Date: June 1970. Ineel index code no. 068-0627-00-400-154062. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Standardization of RP-HPLC methods for the detection of the major peanut allergens Ara h 1, Ara h 2 and Ara h 3

USDA-ARS?s Scientific Manuscript database

Crude peanut extract (CPE) was analyzed for three major allergens (Ara h 1, h 2, and h 3) using a C12 and a C18 column at two wavelengths (280 and 220 nm) and under different solvent conditions. HPLC profiles were compared for retention time, resolution, and peak heights. CPE samples were spiked wit...

VizieR Online Data Catalog: Selecting IRAC counterparts to SMGs (Alberts+, 2013)

NASA Astrophysics Data System (ADS)

Alberts, S.; Wilson, G. W.; Lu, Y.; Johnson, S.; Yun, M. S.; Scott, K. S.; Pope, A.; Aretxaga, I.; Ezawa, H.; Hughes, D. H.; Kawabe, R.; Kim, S.; Kohno, K.; Oshima, T.

2014-05-01

We present a new submm/mm galaxy counterpart identification technique which builds on the use of Spitzer Infrared Array Camera (IRAC) colours as discriminators between likely counterparts and the general IRAC galaxy population. Using 102 radio- and Submillimeter Array-confirmed counterparts to AzTEC sources across three fields [Great Observatories Origins Deep Survey-North, -South and Cosmic Evolution Survey (COSMOS)], we develop a non-parametric IRAC colour-colour characteristic density distribution, which, when combined with positional uncertainty information via likelihood ratios, allows us to rank all potential IRAC counterparts around submillimetre galaxies (SMGs) and calculate the significance of each ranking via the reliability factor. We report all robust and tentative radio counterparts to SMGs, the first such list available for AzTEC/COSMOS, as well as the highest ranked IRAC counterparts for all AzTEC SMGs in these fields as determined by our technique. We demonstrate that the technique is free of radio bias and thus applicable regardless of radio detections. For observations made with a moderate beam size (~18"), this technique identifies ~85% of SMG counterparts. For much larger beam sizes (>~30"), we report identification rates of 33-49%. Using simulations, we demonstrate that this technique is an improvement over using positional information alone for observations with facilities such as AzTEC on the Large Millimeter Telescope and Submillimeter Common User Bolometer Array 2 on the James Clerk Maxwell Telescope. (3 data files).

Automated detection of extended sources in radio maps: progress from the SCORPIO survey

NASA Astrophysics Data System (ADS)

Riggi, S.; Ingallinera, A.; Leto, P.; Cavallaro, F.; Bufano, F.; Schillirò, F.; Trigilio, C.; Umana, G.; Buemi, C. S.; Norris, R. P.

2016-08-01

Automated source extraction and parametrization represents a crucial challenge for the next-generation radio interferometer surveys, such as those performed with the Square Kilometre Array (SKA) and its precursors. In this paper, we present a new algorithm, called CAESAR (Compact And Extended Source Automated Recognition), to detect and parametrize extended sources in radio interferometric maps. It is based on a pre-filtering stage, allowing image denoising, compact source suppression and enhancement of diffuse emission, followed by an adaptive superpixel clustering stage for final source segmentation. A parametrization stage provides source flux information and a wide range of morphology estimators for post-processing analysis. We developed CAESAR in a modular software library, also including different methods for local background estimation and image filtering, along with alternative algorithms for both compact and diffuse source extraction. The method was applied to real radio continuum data collected at the Australian Telescope Compact Array (ATCA) within the SCORPIO project, a pathfinder of the Evolutionary Map of the Universe (EMU) survey at the Australian Square Kilometre Array Pathfinder (ASKAP). The source reconstruction capabilities were studied over different test fields in the presence of compact sources, imaging artefacts and diffuse emission from the Galactic plane and compared with existing algorithms. When compared to a human-driven analysis, the designed algorithm was found capable of detecting known target sources and regions of diffuse emission, outperforming alternative approaches over the considered fields.

MEqTrees Telescope and Radio-sky Simulations and CPU Benchmarking

NASA Astrophysics Data System (ADS)

Shanmugha Sundaram, G. A.

2009-09-01

MEqTrees is a Python-based implementation of the classical Measurement Equation, wherein the various 2×2 Jones matrices are parametrized representations in the spatial and sky domains for any generic radio telescope. Customized simulations of radio-source sky models and corrupt Jones terms are demonstrated based on a policy framework, with performance estimates derived for array configurations, ``dirty''-map residuals and processing power requirements for such computations on conventional platforms.

Using the Very Large Array (VLA) and other radio telescopes to perform a parasitic Search for Extraterrestrial Intelligence (SETI)

NASA Technical Reports Server (NTRS)

Tarter, J.

1985-01-01

This paper describes several attempts to utilize various radio telescopes in a manner that we term "parasitic," that is in a manner that does not interrupt or seriously impact the standard astronomical observing programs in progress at the radio observatories. In the extreme case, only recorded astronomical data are accessed off-line, after the fact, without any burden on the observatory at all.

Using the Very Large Array (VLA) and other radio telescopes to perform a parasitic search for extraterrestrial intelligence (SETI)

NASA Technical Reports Server (NTRS)

Tarter, J. C.

1984-01-01

This paper describes several attempts to utilize various radio telescopes in a manner that is termed 'parasitic', that is in a manner that does not interrupt or seriously impact the standard astronomical observing programs in progress at the radio observatories. In the extreme case, only recorded astronomical data are accessed off-line, after the fact, without any burden on the observatory at all.

Using the Very Large Array (VLA) and other radio telescopes to perform a parasitic Search for Extraterrestrial Intelligence (SETI).

PubMed

Tarter, J

1985-01-01

This paper describes several attempts to utilize various radio telescopes in a manner that we term "parasitic," that is in a manner that does not interrupt or seriously impact the standard astronomical observing programs in progress at the radio observatories. In the extreme case, only recorded astronomical data are accessed off-line, after the fact, without any burden on the observatory at all.

42. ARAIII Prototype assembly and evaluation building ARA630 interior. Typical ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. ARA-III Prototype assembly and evaluation building ARA-630 interior. Typical view room partitions. Ineel photo no. 3-28. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

School climate and physical adolescent relationship abuse: Differences by sex, socioeconomic status, and bullying.

PubMed

Jain, Sonia; Cohen, Alison K; Paglisotti, Taylor; Subramanyam, Malavika A; Chopel, Alison; Miller, Elizabeth

2018-07-01

Little is known about the association between school climate and adolescent relationship abuse (ARA). We used 2011-2012 data from surveys of California public school students (in the United States of America) who were in a dating relationship in the last year (n = 112 378) to quantify the association between different school climate constructs and physical ARA. Fifty-two percent of students were female, and all students were in 9th or 11th grade (approximately ages 14-17). Over 11% of students reported experiencing physical ARA in the last year. Increased school connectedness, meaningful opportunities for participation, perceived safety, and caring relationships with adults at school were each significantly associated with lower odds of physical ARA. Increased violence victimization and school-level bullying victimization were associated with higher odds of physical ARA. These school climate-ARA associations were significantly moderated by student sex, school socioeconomic status, and school-level bullying victimization. School climate interventions may have spillover benefits for ARA prevention. Copyright © 2018 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

The Allen Telescope Array

NASA Astrophysics Data System (ADS)

DeBoer, David R.; Welch, William J.; Dreher, John; Tarter, Jill; Blitz, Leo; Davis, Michael; Fleming, Matt; Bock, Douglas; Bower, Geoffrey; Lugten, John; Girmay-Keleta, G.; D'Addario, Larry R.; Harp, Gerry R.; Ackermann, Rob; Weinreb, Sander; Engargiola, Greg; Thornton, Doug; Wadefalk, Niklas

2004-10-01

The Allen Telescope Array, originally called the One Hectare Telescope (1hT) [1] will be a large array radio telescope whose novel characteristics will be a wide field of view (3.5 deg-GHz HPBW), continuous frequency coverage of 0.5 - 11 GHz, four dual-linear polarization output bands of 100 MHz each, four beams in each band, two 100 MHz spectral correlators for two of the bands, and hardware for RFI mitigation built in. Its scientific motivation is for deep SETI searches and, at the same time, a variety of other radio astronomy projects, including transient (e.g. pulsar) studies, HI mapping of the Milky Way and nearby galaxies, Zeeman studies of the galactic magnetic field in a number of transitions, mapping of long chain molecules in molecular clouds, mapping of the decrement in the cosmic background radiation toward galaxy clusters, and observation of HI absorption toward quasars at redshifts up to z=2. The array is planned for 350 6.1-meter dishes giving a physical collecting area of about 10,000 square meters. The large number of components reduces the price with economies of scale. The front end receiver is a single cryogenically cooled MIMIC Low Noise Amplifier covering the whole band. The feed is a wide-band log periodic feed of novel design, and the reflector system is an offset Gregorian for minimum sidelobes and spillover. All preliminary and critical design reviews have been completed. Three complete antennas with feeds and receivers are under test, and an array of 33 antennas is under construction at the Hat Creek Radio Observatory for the end of 2004. The present plan is to have a total of about 200 antennas completed by the summer of 2006 and the balance of the array finished before the end of the decade.

ASKAP Joins the Hunt for Mysterious Bursts

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-05-01

A new telescope, the Australian Square Kilometre Array Pathfinder (ASKAP), has joined the search for energetic and elusive fast radio bursts. And in just a few days of looking, its already had success!Elusive TransientsThe Parkes radio telescope, which has detected all but five of the fast radio bursts published to date, has a very narrow field of view. [CSIRO]Fast radio bursts are mysterious millisecond-duration radio pulses that were first discovered around a decade ago. Since that time particularly in recent years weve made some progress toward the goal of localizing them. Were now fairly convinced that fast radio bursts come from outside of the galaxy, and yet theyre enormously bright orders of magnitude more luminous than any pulse seen from the Milky Way.Better identification of where these mysterious bursts come from would help us to determine what they are. But so far, weve discovered only around 30 such bursts, despite the fact that theyre estimated to occur at a rate of 3,000 events per day across the whole sky.Why are they so hard to find? Due to their short duration, effective detection would require instantaneous coverage of a very large fraction of the sky. The Parkes radio telescope which has detected all but five of the fast radio bursts published to date has a field of view spanning less than a square degree,significantly limiting our ability to rapidly survey for these transients.FRB 170107s band-averaged pulse (top) and dynamic spectrum (bottom). [Bannister et al. 2017]A New Array in TownA new player is now on the scene, however, and its already had huge success. ASKAP is a wide-field radio telescope made up of an array of 12-meter antennas. Using phased-array-feed technology, ASKAP is able to instantaneously observe an effective area of 160 square degrees an enormous field compared to Parkes 0.6 square degrees! This capability significantly increases our chances of being able to detect fast radio bursts.In a new study led by Keith Bannister (Australia Telescope National Facility, CSIRO Astronomy and Space Science), a team of scientists presents results from ASKAPs first 3.4-day pilot survey. Bannister and collaborators announce that in this brief time, ASKAP has already detected a fast radio burst: FRB 170107, an especially luminous, 2 millisecond burst that confirms the presence of an ultra-bright population of fast radio bursts.Looking to the FutureLocalization of FRB 170107. [Adapted from Bannister et al. 2017]Using the multiple bands of ASKAP, the authors were able to constrain the position of FRB 170107 to a region just 8 x 8 in size. No known field galaxies exist in that region, so were still not sure exactly where it came from, but this localization is already a significant achievement.The discovery and characterization of a burst already after such a short initial campaign suggests that ASKAP will become a very powerful tool for detecting fast radio bursts including some of the rarest bursts, ultra-bright ones like FRB 170107. We finally appear to be poised to resolve some of the mysteries of this population of transients.CitationK. W. Bannister et al 2017 ApJL 841 L12. doi:10.3847/2041-8213/aa71ff

X-rays from the radio halo of Virgo A = M87

NASA Technical Reports Server (NTRS)

1985-01-01

The purpose of this study is to investigate in more detail the associated X-ray and radio emission in the Virgo A halo discovered by SGF. Improved Einstein HRI data and new radio maps obtained with the Very Large Array are described and the relation between the X-ray and radio structures is carefully examined. Several possible explanations are presented for the X-ray emission. The inverse compton model is found to be viable only if the magnetic field is variable and substantially weaker than the equipartition value. The principal alternative is excess thermal X-rays due to compression of the intracluster medium by the radio lobe. In either case, the association of such prominent radio and X-ray structures is unique among known radio galaxies.

Algorithm for Aligning an Array of Receiving Radio Antennas

NASA Technical Reports Server (NTRS)

Rogstad, David

2006-01-01

A digital-signal-processing algorithm (somewhat arbitrarily) called SUMPLE has been devised as a means of aligning the outputs of multiple receiving radio antennas in a large array for the purpose of receiving a weak signal transmitted by a single distant source. As used here, aligning signifies adjusting the delays and phases of the outputs from the various antennas so that their relatively weak replicas of the desired signal can be added coherently to increase the signal-to-noise ratio (SNR) for improved reception, as though one had a single larger antenna. The method was devised to enhance spacecraft-tracking and telemetry operations in NASA's Deep Space Network (DSN); the method could also be useful in such other applications as both satellite and terrestrial radio communications and radio astronomy. Heretofore, most commonly, alignment has been effected by a process that involves correlation of signals in pairs. This approach necessitates the use of a large amount of hardware most notably, the N(N - 1)/2 correlators needed to process signals from all possible pairs of N antennas. Moreover, because the incoming signals typically have low SNRs, the delay and phase adjustments are poorly determined from the pairwise correlations. SUMPLE also involves correlations, but the correlations are not performed in pairs. Instead, in a partly iterative process, each signal is appropriately weighted and then correlated with a composite signal equal to the sum of the other signals (see Figure 1). One benefit of this approach is that only N correlators are needed; in an array of N much greater than 1 antennas, this results in a significant reduction of the amount of hardware. Another benefit is that once the array achieves coherence, the correlation SNR is N - 1 times that of a pair of antennas.

Small jets in radio-loud hot DOGs

NASA Astrophysics Data System (ADS)

Lonsdale, C. J.; Whittle, M.; Trapp, A.; Patil, P.; Lonsdale, C. J.; Thorp, R.; Lacy, M.; Kimball, A. E.; Blain, A.; Jones, S.; Kim, M.

2016-02-01

We address the impact of young radio jets on the ISM and star formation in a sample of radiatively efficient, highly obscured, radio AGN with look back times that place them near the peak of the galaxy and BH building era, z˜ 1-3. By selecting systems with a high mid-infrared (MIR) luminosity we aim to identify radiatively efficient (``quasar-mode'' or ``radiative-mode") AGN in a peak fueling phase, and by selecting compact radio sources we favor young or re-generated radio jets which are confined within the hosts. By selecting AGN which are very red through the optical-MIR we favor highly obscured systems likely to have been recently merger-triggered and still in the pre-blow-out phase of AGN feedback into the surrounding ISM. ALMA imaging at 345 GHz of 49 sources has revealed that they are accretion dominated, relative to star formation, with luminosities reaching 1014 L⊙. Extensive VLA imaging at 8-10 GHz in both A-array and B-array for 155 sources reveals that the majority of these powerful radio systems are compact on < 2-5 kpc scales while some have resolved structures on 3-25 kpc scales, and a small number have giant radio lobes on hundreds of kpc scales. The majority of the GHz range radio SEDs are typical of optically thin synchrotron, however for the 34 sources with data at more than 2 frequencies, 40 % are likely to be CSS, GPS, or HFP sources. VLBA imaging of 62 sources reveals varied morphologies, from unresolved sources to complex multicomponent 1-10 mas scale structures. Data from ALMA, VLA, and VLBA

A Radio Astronomy Curriculum for the Middle School Classroom

NASA Astrophysics Data System (ADS)

Davis, J.; Finley, D. G.

2000-12-01

In the summer of 2000, two teachers working on a Masters of Science Teaching program at New Mexico Institute of Mining and Technology, spent eight weeks as interns at the Array Operations Center for the National Radio Astronomy Observatory (NRAO) in Socorro, New Mexico, under the auspices of the National Science Foundation's (NSF) Research Experience for Teachers (RET) program. The resulting projects will directly benefit students in the indvidual classrooms, as well as provide an easy-to-access resource for other educators. One of the products is a Radio Astronomy Curriculum for upper middle school classes. Radio astronomy images, based on scientific research results using NRAO's Very Large Array, are featured on trading cards which include an explanation, a ``web challenge'', and in some cases, a comparison of radio and optical images. Each trading card has corresponding lesson plans with background information about the images and astronomy concepts needed to do the lessons. Comparison of optical and radio astronomy is used as much as possible to explain the information from research using visible and radio wavelengths. New Mexico's Content Standards and Benchmarks (developed using national standards) for science education was used as a guide for the activities. The three strands of science listed in the standards, Unifying Concepts and Processes, Science as Inquiry, and Science Content are addressed in the lessons. Higher level thinking and problem solving skills are featured throughout the curriculum. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc. The NSF's RET program is gratefully acknowledged.

The Least Mean Squares Adaptive FIR Filter for Narrow-Band RFI Suppression in Radio Detection of Cosmic Rays

NASA Astrophysics Data System (ADS)

Szadkowski, Zbigniew; Głas, Dariusz

2017-06-01

Radio emission from the extensive air showers (EASs), initiated by ultrahigh-energy cosmic rays, was theoretically suggested over 50 years ago. However, due to technical limitations, successful collection of sufficient statistics can take several years. Nowadays, this detection technique is used in many experiments consisting in studying EAS. One of them is the Auger Engineering Radio Array (AERA), located within the Pierre Auger Observatory. AERA focuses on the radio emission, generated by the electromagnetic part of the shower, mainly in geomagnetic and charge excess processes. The frequency band observed by AERA radio stations is 30-80 MHz. Thus, the frequency range is contaminated by human-made and narrow-band radio frequency interferences (RFIs). Suppression of contaminations is very important to lower the rate of spurious triggers. There are two kinds of digital filters used in AERA radio stations to suppress these contaminations: the fast Fourier transform median filter and four narrow-band IIR-notch filters. Both filters have worked successfully in the field for many years. An adaptive filter based on a least mean squares (LMS) algorithm is a relatively simple finite impulse response (FIR) filter, which can be an alternative for currently used filters. Simulations in MATLAB are very promising and show that the LMS filter can be very efficient in suppressing RFI and only slightly distorts radio signals. The LMS algorithm was implemented into a Cyclone V field programmable gate array for testing the stability, RFI suppression efficiency, and adaptation time to new conditions. First results show that the FIR filter based on the LMS algorithm can be successfully implemented and used in real AERA radio stations.

The jet/wind outflow in Centaurus A: a local laboratory for AGN feedback

NASA Astrophysics Data System (ADS)

McKinley, B.; Tingay, S. J.; Carretti, E.; Ellis, S.; Bland-Hawthorn, J.; Morganti, R.; Line, J.; McDonald, M.; Veilleux, S.; Wahl Olsen, R.; Sidonio, M.; Ekers, R.; Offringa, A. R.; Procopio, P.; Pindor, B.; Wayth, R. B.; Hurley-Walker, N.; Bernardi, G.; Gaensler, B. M.; Haverkorn, M.; Kesteven, M.; Poppi, S.; Staveley-Smith, L.

2018-03-01

We present new radio and optical images of the nearest radio galaxy Centaurus A and its host galaxy NGC 5128. We focus our investigation on the northern transition region, where energy is transported from the ˜5 kpc (˜5 arcmin) scales of the northern inner lobe (NIL) to the ˜30 kpc (˜30 arcmin) scales of the northern middle lobe (NML). Our Murchison Widefield Array observations at 154 MHz and our Parkes radio telescope observations at 2.3 GHz show diffuse radio emission connecting the NIL to the NML, in agreement with previous Australia Telescope Compact Array observations at 1.4 GHz. Comparison of these radio data with our wide-field optical emission-line images show the relationship between the NML radio emission and the ionized filaments that extend north from the NIL, and reveal a new ionized filament to the east, possibly associated with a galactic wind. Our deep optical images show clear evidence for a bipolar outflow from the central galaxy extending to intermediate scales, despite the non-detection of a southern radio counterpart to the NML. Thus, our observational overview of Centaurus A reveals a number of features proposed to be associated with active galactic nucleus feedback mechanisms, often cited as likely to have significant effects in galaxy evolution models. As one of the closest galaxies to us, Centaurus A therefore provides a unique laboratory to examine feedback mechanisms in detail.

Cosmic Extremes: Probing Energetic Transients with Radio Observations

NASA Astrophysics Data System (ADS)

Denham Alexander, Kate

2018-01-01

With the advent of sensitive facilities like the Karl G. Jansky Very Large Array (VLA) and planning well underway for vastly more powerful wide-field interferometers like the Square Kilometer Array, the study of radio astrophysical transients is poised for dramatic growth. Radio observations provide a unique window into a wide variety of transient events, from gamma-ray bursts (GRBs) to supernovae to tidal disruption events (TDEs) in which a star is torn apart by a supermassive black hole. In particular, GRBs and TDEs have emerged as valuable probes of some of the most extreme physics in the Universe. In these high-energy laboratories, the longer timescale of radio emission allows for extensive followup and characterization of the event energies and the densities of surrounding material. I will present high-cadence broadband radio studies of GRB afterglows and TDEs undertaken with the goal of learning more about their physical properties, the physics underlying the formation and growth of relativistic jets and outflows, and the environments in which these events occur. Our observations confirm that only a small fraction of TDEs produce relativistic jets but reveal low-luminosity, non-relativistic outflows in two nearby TDEs, allowing us to begin constraining the bulk of the TDE population. Our GRB radio observations reveal both intrinsic variability (reverse shocks) and extrinsic variability (interstellar scintillation). The insights derived from these studies will be invaluable for designing and interpreting the results from future radio transient surveys.

Radio and X-Ray Observations of SN 2006jd: Another Strongly Interacting Type IIn Supernova

NASA Technical Reports Server (NTRS)

Chandra, Poonam; Chevalier, Roger A.; Chugai, Nikolai; Fransson, Claes; Irwin, Christopher M.; Soderberg, Alicia M.; Chakraborti, Sayan; Immler, Stefan

2012-01-01

We report four years of radio and X-ray monitoring of the Type IIn supernova SN 2006jd at radio wavelengths with the Very Large Array, Giant Metrewave Radio Telescope and Expanded Very Large Array at X-ray wavelengths with Chandra, XMM-Newton and Swift-XRT. We assume that the radio and X-ray emitting particles are produced by shock interaction with a dense circumstellar medium. The radio emission shows an initial rise that can be attributed to free-free absorption by cool gas mixed into the nonthermal emitting region external free-free absorption is disfavored because of the shape of the rising light curves and the low gas column density inferred along the line of sight to the emission region. The X-ray luminosity implies a preshock circumstellar density approximately 10(exp 6) per cubic meter at a radius r approximately 2 x 10(exp 16) centimeter, but the column density inferred from the photoabsorption of X-rays along the line of sight suggests a significantly lower density. The implication may be an asymmetry in the interaction. The X-ray spectrum shows Fe line emission at 6.9 keV that is stronger than is expected for the conditions in the X-ray emitting gas. We suggest that cool gas mixed into the hot gas plays a role in the line emission. Our radio and X-ray data both suggest the density profile is flatter than r2 because of the slow evolution of the unabsorbed emission.

Is There a Maximum Star Formation Rate in High-redshift Galaxies?

NASA Astrophysics Data System (ADS)

Barger, A. J.; Cowie, L. L.; Chen, C.-C.; Owen, F. N.; Wang, W.-H.; Casey, C. M.; Lee, N.; Sanders, D. B.; Williams, J. P.

2014-03-01

We use the James Clerk Maxwell Telescope's SCUBA-2 camera to image a 400 arcmin2 area surrounding the GOODS-N field. The 850 μm rms noise ranges from a value of 0.49 mJy in the central region to 3.5 mJy at the outside edge. From these data, we construct an 850 μm source catalog to 2 mJy containing 49 sources detected above the 4σ level. We use an ultradeep (11.5 μJy at 5σ) 1.4 GHz image obtained with the Karl G. Jansky Very Large Array together with observations made with the Submillimeter Array to identify counterparts to the submillimeter galaxies. For most cases of multiple radio counterparts, we can identify the correct counterpart from new and existing Submillimeter Array data. We have spectroscopic redshifts for 62% of the radio sources in the 9' radius highest sensitivity region (556/894) and 67% of the radio sources in the GOODS-N region (367/543). We supplement these with a modest number of additional photometric redshifts in the GOODS-N region (30). We measure millimetric redshifts from the radio to submillimeter flux ratios for the unidentified submillimeter sample, assuming an Arp 220 spectral energy distribution. We find a radio-flux-dependent K - z relation for the radio sources, which we use to estimate redshifts for the remaining radio sources. We determine the star formation rates (SFRs) of the submillimeter sources based on their radio powers and their submillimeter fluxes and find that they agree well. The radio data are deep enough to detect star-forming galaxies with SFRs >2000 M ⊙ yr-1 to z ~ 6. We find galaxies with SFRs up to ~6000 M ⊙ yr-1 over the redshift range z = 1.5-6, but we see evidence for a turn-down in the SFR distribution function above 2000 M ⊙ yr-1. The James Clerk Maxwell Telescope is operated by the Joint Astronomy Centre on behalf of the Science and Technology Facilities Council of the United Kingdom, the National Research Council of Canada, and (until 2013 March 31) the Netherlands Organisation for Scientific Research. The W. M. Keck Observatory is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation.

HPLC-MS/MS method for the simultaneous determination of MB07133 and its metabolites, cytarabine and arabinofuranosyluracil, in rat plasma.

PubMed

Wang, Dan; Xiao, Qingqing; Yang, Wanqiu; Qian, Wei; Yang, Jin

2016-02-20

MB07133 is an intravenously administered cytarabine mononucleotide (araCMP) prodrug, for the treatment of hepatocellular carcinoma (HCC). A simple, selective and sensitive HPLC-MS/MS method using high pressure liquid chromatography (HPLC) coupled to triple-quadrupole mass spectrometer, was developed and validated for the detection of prodrug MB07133 and its metabolites, cytarabine (araC) and arabinofuranosyluracil (araU) in rat plasma. Protein precipitation using 3% trichloroacetic acid (TCA) was employed to extract analytes from 100μL rat plasma. Adequate separation of araC and araU from their endogenous compounds was achieved on the Synergi(®) fusion-RP column (150mm×4.6mm, 4μm) by a gradient-elution with a mobile phase consisting of ammonium formate (1mM) and methanol at a flow rate of 1mL/min. Multiple reaction monitoring mode (MRM) was applied in the detection of MB07133, araC, araU and Ganciclovir (internal standard) with ion pairs 441.2/330.2, 244.2/112.2, 245.2/113.2 and 256.1/152.2, respectively. The assays were validated with respect to specificity, linearity (100-50000ng/mL for MB07133, 2-1000ng/mL for araC and araU), accuracy and precision, extraction recovery, matrix effect and stability. The validated method has been successfully applied to an intravenous bolus pharmacokinetic study of MB07133 in male Sprague-Dawley rats (18mg/kg i.v.). Copyright © 2015 Elsevier B.V. All rights reserved.

Temporal Trends in Anesthesia-related Adverse Events in Cesarean Deliveries, New York State, 2003-2012.

PubMed

Guglielminotti, Jean; Wong, Cynthia A; Landau, Ruth; Li, Guohua

2015-11-01

Cesarean delivery (CD) is associated with significantly increased risks of anesthesia-related adverse events (ARAEs) and nonanesthetic perioperative morbidity compared with vaginal delivery. Temporal trends in these adverse outcomes remain unknown despite efforts to improve maternal safety. This study examines temporal trends in ARAEs and nonanesthetic perioperative complications in CDs in New York hospitals. Data are from the State Inpatient Database for New York, 2003-2012. ARAEs, including minor and major ARAEs, and nonanesthetic perioperative complications were identified through International Classification of Diseases, Ninth Revision, Clinical Modification codes. Statistical significance in time trends was assessed using the Cochran-Armitage test and multivariable logistic regression. Of the 785,854 CDs studied, 5,715 (730 per 100,000; 95% CI, 710 to 750) had at least one ARAE and 7,040 had at least one perioperative complication (890 per 100,000; 95% CI, 870 to 920). The overall annual rate of ARAEs decreased from 890 per 100,000 in 2003 to 660 in 2012 (25% decrease; 95% CI, 16 to 34; P < 0.0001). The rate of minor ARAEs decreased 23% (95% CI, 13 to 32) and of major ARAEs decreased 43% (95% CI, 23 to 63). No decrease was observed in the rate of ARAEs for CDs performed under general anesthesia. The rate of nonanesthetic complications increased 47% (95% CI, 31 to 63; P < 0.0001). Anesthesia-related outcomes in cesarean deliveries appear to have improved significantly across hospitals in New York in the past decade. Perioperative nonanesthetic complications remain a serious healthcare issue.

VERY LARGE ARRAY OBSERVATIONS OF DG TAU'S RADIO JET: A HIGHLY COLLIMATED THERMAL OUTFLOW

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynch, C.; Mutel, R. L.; Gayley, K. G.

2013-03-20

The active young protostar DG Tau has an extended jet that has been well studied at radio, optical, and X-ray wavelengths. We report sensitive new Very Large Array (VLA) full-polarization observations of the core and jet between 5 GHz and 8 GHz. Our high angular resolution observation at 8 GHz clearly shows an unpolarized inner jet with a size of 42 AU (0.''35) extending along a position angle similar to the optical-X ray outer jet. Using our nearly coeval 2012 VLA observations, we find a spectral index {alpha} = +0.46 {+-} 0.05, which combined with the lack of polarization ismore » consistent with bremsstrahlung (free-free) emission, with no evidence for a non-thermal coronal component. By identifying the end of the radio jet as the optical depth unity surface, and calculating the resulting emission measure, we find that our radio results are in agreement with previous optical line studies of electron density and consequent mass-loss rate. We also detect a weak radio knot at 5 GHz located 7'' from the base of the jet, coincident with the inner radio knot detected by Rodriguez et al. in 2009 but at lower surface brightness. We interpret this as due to expansion of post-shock ionized gas in the three years between observations.« less

Estimating Noise in the Hydrogen Epoch of Reionization Array

NASA Astrophysics Data System (ADS)

Englund Mathieu, Philip; HERA Team

2017-01-01

The Hydrogen Epoch of Reionization Array (HERA) is a radio telescope dedicated to observing large scale structure during and prior to the epoch of reionization. Once completed, HERA will have unprecedented sensitivity to the 21-cm signal from hydrogen reionization. This poster will present time- and frequency-subtraction methods and results from a preliminary analysis of the noise characteristics of the nineteen-element pathfinder array.

Prospects for gravitational wave astronomy with next generation large-scale pulsar timing arrays

NASA Astrophysics Data System (ADS)

Wang, Yan; Mohanty, Soumya D.

2018-02-01

Next generation radio telescopes, namely the Five-hundred-meter Aperture Spherical Telescope (FAST) and the Square Kilometer Array (SKA), will revolutionize the pulsar timing arrays (PTAs) based gravitational wave (GW) searches. We review some of the characteristics of FAST and SKA, and the resulting PTAs, that are pertinent to the detection of gravitational wave signals from individual supermassive black hole binaries.

Sugar-modified poly(propylene imine) dendrimers as drug delivery agents for cytarabine to overcome drug resistance.

PubMed

Szulc, Aleksandra; Pulaski, Lukasz; Appelhans, Dietmar; Voit, Brigitte; Klajnert-Maculewicz, Barbara

2016-11-20

Maltose-modified poly(propylene imine) glycodendrimers (PPI-m OS) of the 4th generation provide a promising strategy for leukemia treatment. Anticancer therapy with nucleoside analog drugs such as cytarabine (Ara-C) frequently has limited efficacy due to drug resistance, inefficient uptake and accumulation of the drug inside cancer cells where it has to be transformed into the active triphosphate congener. The cationic nature of PPI dendrimers makes it possible to form complexes with nucleotide Ara-C triphosphate forms (Ara-CTP). The aim of this work was to test the concept of applying PPI glycodendrimers as drug delivery devices in order to facilitate the delivery of activated cytarabine to cancer cells to overcome metabolic limitations of the drug. The study has been carried out using 1301 and HL-60 leukemic cell lines as well as peripheral blood mononuclear cells. The results of cytotoxicity and apoptosis assays showed enhanced activity of Ara-C triphosphate form (Ara-CTP) complexed with PPI-m dendrimers in relation to free Ara-C and Ara-CTP against 1301 leukemic cells. Secondly, enhanced uptake and cytotoxicity of Ara-CTP-dendrimers complexes toward 1301 cells with blocked human equilibrative nucleoside transporter - hENT1 suggested that this combination might be a versatile candidate for chemotherapy against resistant acute lymphoblastic leukemia cells with lower expression of hENT1. Copyright © 2016 Elsevier B.V. All rights reserved.

Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma.

PubMed

Qi, Na; Cai, Cuifang; Zhang, Wei; Niu, Yantao; Yang, Jingyu; Wang, Lihui; Tian, Bin; Liu, Xiaona; Lin, Xia; Zhang, Yu; Zhang, Yan; He, Haibing; Chen, Kang; Tang, Xing

2014-09-10

This study described the development of vesicular phospholipid gels (VPGs) for sustained delivery of cytarabine (Ara-C) for the treatment of xenografted glioma. Ara-C-loaded VPGs in the state of a semisolid phospholipid dispersion looked like numerous vesicles tightly packing together under the freeze-fracture electron microscopy (FF-TEM), their release profiles displayed sustained drug release up to 384 h in vitro. The biodistribution of Ara-C in the rat brain showed that Ara-C-loaded VPGs could maintain therapeutic concentrations up to 5mm distance from the implantation site in brain tissue within 28 days. At the same time, fluorescence micrograph confirmed drug distribution in brain tissue visually. Furthermore, after single administration, Ara-C-loaded VPGs group significantly inhibited the U87-MG glioma growth in right flank in comparison with Ara-C solution (p<0.01). It was explained that the entrapped drug in VPGs could avoid degradation from cytidine deaminase and sustained release of drug from Ara-C-loaded VPGs could maintain the effective therapeutic levels for a long time around the tumor. In conclusion, Ara-C-loaded VPGs, with the properties of sustained release, high penetration capacity, nontoxicity and no shape restriction of the surgical cavity, are promising local delivery systems for post-surgical sustained chemotherapy against glioma. Copyright © 2014 Elsevier B.V. All rights reserved.

Global Estimates of Dietary Intake of Docosahexaenoic Acid and Arachidonic Acid in Developing and Developed Countries.

PubMed

Forsyth, Stewart; Gautier, Sheila; Salem, Norman

2016-01-01

For international recommendations on docosahexaenoic acid (DHA) and arachidonic acid (ARA) dietary intake to be valid, there needs to be a greater understanding of dietary patterns across both the developed and developing world. The aim of this investigation was to provide a global overview of dietary intake of DHA and ARA. Food balance sheets from the Food and Agriculture Organisation Statistics Division and fatty acid composition data from Australian food composition tables in Nutrient Tables 2010 were utilised to generate median per capita intake estimates for DHA and ARA in 175 countries worldwide. Estimated dietary intake per capita for DHA and ARA in 47 developed and 128 developing countries demonstrated that 48% of the 175 countries have an ARA intake of <150 mg/day and 64% have a dietary DHA intake of <200 mg/day. There was a direct relationship between dietary ARA and DHA intake and the per capita gross national income of the country. Regional analysis showed the lowest ARA and DHA dietary intake in Sub-Saharan Africa and Central and Southern Asian populations. This study demonstrates there are many populations worldwide that have ARA and DHA intake that do not reflect current international recommendations, and the public health consequences of this global inadequacy need to be urgently considered. © 2016 S. Karger AG, Basel.

Sensitive radio survey of obscured quasar candidates

NASA Astrophysics Data System (ADS)

Alexandroff, Rachael M.; Zakamska, Nadia L.; van Velzen, Sjoert; Greene, Jenny E.; Strauss, Michael A.

2016-12-01

We study the radio properties of moderately obscured quasars in samples at both low (z ˜ 0.5) and high (z ˜ 2.5) redshift to understand the role of radio activity in accretion, using the Karl G. Jansky Very Large Array (VLA) at 6.0 GHz and 1.4 GHz. Our z ˜ 2.5 sample consists of optically selected obscured quasar candidates, all of which are radio-quiet, with typical radio luminosities of νLν[1.4 GHz] ≲ 1040 erg s-1. Only a single source is individually detected in our deep (rms˜10 μJy) exposures. This population would not be identified by radio-based selection methods used for distinguishing dusty star-forming galaxies and obscured active nuclei. In our pilot A-array study of z ˜ 0.5 radio-quiet quasars, we spatially resolve four of five objects on scales ˜5 kpc and find they have steep spectral indices with an average value of α = -0.75. Therefore, radio emission in these sources could be due to jet-driven or radiatively driven bubbles interacting with interstellar material on the scale of the host galaxy. Finally, we also study the additional population of ˜200 faint ( ˜ 40 μJy-40 mJy) field radio sources observed over ˜120 arcmin2 of our data. 60 per cent of these detections (excluding our original targets) are matched in the Sloan Digital Sky Survey (SDSS) and/or Wide-Field Infrared Survey Explorer (WISE) and are, in roughly equal shares, active galactic nuclei (AGN) at a broad range of redshifts, passive galaxies with no other signs of nuclear activity and infrared-bright but optically faint sources. Spectroscopically or photometrically confirmed star-forming galaxies constitute only a small minority of the matches. Such sensitive radio surveys allow us to address important questions of AGN evolution and evaluate the AGN contribution to the radio-quiet sky.

A Submillimeter Perspective on the Goods Fields. II. The High Radio Power Population in the Goods-N

NASA Astrophysics Data System (ADS)

Barger, A. J.; Cowie, L. L.; Owen, F. N.; Hsu, L.-Y.; Wang, W.-H.

2017-01-01

We use ultradeep 20 cm data from the Karl G. Jansky Very Large Array and 850 μm data from SCUBA-2 and the Submillimeter Array of an 124 arcmin2 region of the Chandra Deep Field-north to analyze the high radio power ({P}20{cm}> {10}31 erg s-1 Hz-1) population. We find that 20 (42 ± 9%) of the spectroscopically identified z> 0.8 sources have consistent star formation rates (SFRs) inferred from both submillimeter and radio observations, while the remaining sources have lower (mostly undetected) submillimeter fluxes, suggesting that active galactic nucleus (AGN) activity dominates the radio power in these sources. We develop a classification scheme based on the ratio of submillimeter flux to radio power versus radio power and find that it agrees with AGN and star-forming galaxy classifications from Very Long Baseline Interferometry. Our results provide support for an extremely rapid drop in the number of high SFR galaxies above about a thousand solar masses per year (Kroupa initial mass function) and for the locally determined relation between X-ray luminosity and radio power for star-forming galaxies applying at high redshifts and high radio powers. We measure far-infrared (FIR) luminosities and find that some AGNs lie on the FIR-radio correlation, while others scatter below. The AGNs that lie on the correlation appear to do so based on their emission from the AGN torus. We measure a median radio size of 1.″0 ± 0.3 for the star-forming galaxies. The radio sizes of the star-forming galaxies are generally larger than those of the AGNs. The W. M. Keck Observatory is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation.

47 CFR 73.154 - AM directional antenna partial proof of performance measurements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false AM directional antenna partial proof of...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.154 AM directional antenna... measurements are to be made within 3 to 15 kilometers from the center of the antenna array. When a monitoring...

47 CFR 73.154 - AM directional antenna partial proof of performance measurements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false AM directional antenna partial proof of...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.154 AM directional antenna... measurements are to be made within 3 to 15 kilometers from the center of the antenna array. When a monitoring...

47 CFR 73.154 - AM directional antenna partial proof of performance measurements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false AM directional antenna partial proof of...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.154 AM directional antenna... measurements are to be made within 3 to 15 kilometers from the center of the antenna array. When a monitoring...

47 CFR 73.154 - AM directional antenna partial proof of performance measurements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false AM directional antenna partial proof of...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.154 AM directional antenna... measurements are to be made within 3 to 15 kilometers from the center of the antenna array. When a monitoring...

41. ARAIII Prototype assembly and evaluation building ARA630. West end ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. ARA-III Prototype assembly and evaluation building ARA-630. West end and south side of building. Camera facing northeast. Ineel photo no. 3-22. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

104. ARAIII. Interior view of room 110 in ARA607 used ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

104. ARA-III. Interior view of room 110 in ARA-607 used as data acquisition control room. Camera facing northeast. Ineel photo no. 81-103. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

First IPS Radio Sources Detected By MEXART

NASA Astrophysics Data System (ADS)

Mejia-Ambriz, J.; Gonzalez-Esparza, A.; Carrillo-Vargas, A.; Villanueva-Hernandez, P.; Aguilar-Rodriguez, E.; Andrade-Mascote, E.; Vazquez-Hernandez, S.; Sierra-Figueredo, P.; Ananthakrishnan, S.; Manoharan, P.

2008-12-01

We present a first study of strong radio sources that are known to exhibit interplanetary scintillations (IPS) detected by the Mexican Array Radio Telescope (MEXART). These observations were made using one quarter of the total antenna (16 rows of 64 dipoles each) and a Butler Matrix (BM) of 16X16 ports. The BM displays 16 beams at different declinations (from -48 to +88 degrees). We report the directionality and efficiency of the beams. These first observations of radio IPS sources and the calibration of the BM is the first step to initiate MEXART IPS maps in the near future.

Rectenna for high-voltage applications

NASA Technical Reports Server (NTRS)

Epp, Larry W. (Inventor); Khan, Abdur R. (Inventor)

2002-01-01

An energy transfer system is disclosed. The system includes patch elements, shielding layers, and energy rectifying circuits. The patch elements receive and couple radio frequency energy. The shielding layer includes at least one opening that allows radio frequency energy to pass through. The openings are formed and positioned to receive the radio frequency energy and to minimize any re-radiating back toward the source of energy. The energy rectifying circuit includes a circuit for rectifying the radio frequency energy into dc energy. A plurality of energy rectifying circuits is arranged in an array to provide a sum of dc energy generated by the energy rectifying circuit.

Compact field programmable gate array-based pulse-sequencer and radio-frequency generator for experiments with trapped atoms.

PubMed

Pruttivarasin, Thaned; Katori, Hidetoshi

2015-11-01

We present a compact field-programmable gate array (FPGA) based pulse sequencer and radio-frequency (RF) generator suitable for experiments with cold trapped ions and atoms. The unit is capable of outputting a pulse sequence with at least 32 transistor-transistor logic (TTL) channels with a timing resolution of 40 ns and contains a built-in 100 MHz frequency counter for counting electrical pulses from a photo-multiplier tube. There are 16 independent direct-digital-synthesizers RF sources with fast (rise-time of ∼60 ns) amplitude switching and sub-mHz frequency tuning from 0 to 800 MHz.

Compact field programmable gate array-based pulse-sequencer and radio-frequency generator for experiments with trapped atoms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pruttivarasin, Thaned, E-mail: thaned.pruttivarasin@riken.jp; Katori, Hidetoshi; Innovative Space-Time Project, ERATO, JST, Bunkyo-ku, Tokyo 113-8656

We present a compact field-programmable gate array (FPGA) based pulse sequencer and radio-frequency (RF) generator suitable for experiments with cold trapped ions and atoms. The unit is capable of outputting a pulse sequence with at least 32 transistor-transistor logic (TTL) channels with a timing resolution of 40 ns and contains a built-in 100 MHz frequency counter for counting electrical pulses from a photo-multiplier tube. There are 16 independent direct-digital-synthesizers RF sources with fast (rise-time of ∼60 ns) amplitude switching and sub-mHz frequency tuning from 0 to 800 MHz.

Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors.

PubMed

Tai, Pei-Ju; Huang, Ya-Hui; Shih, Chung-Hsuan; Chen, Ruey-Nan; Chen, Chi-De; Chen, Wei-Jan; Wang, Chia-Siu; Lin, Kwang-Huei

2007-07-01

Thyroid hormone (T3) regulates multiple physiological processes during development, growth, differentiation, and metabolism. Most T3 actions are mediated via thyroid hormone receptors (TRs) that are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. The effects of T3 treatment on target gene regulation was previously examined in TRalpha1-overexpressing hepatoma cell lines (HepG2-TRalpha1). Androgen receptor (AR)-associated protein 70 (ARA70) was one gene found to be up-regulated by T3. The ARA70 is a ligand-dependent coactivator for the AR and was significantly increased by 4- to 5-fold after T3 treatment by Northern blot analyses in the HepG2-TRalpha1 stable cell line. T3 induced a 1- to 2-fold increase in the HepG2-TRbeta1 stable cell line. Both stable cell lines attained the highest fold expression after 24 h treatment with 10 nM T3. The ARA70 protein was increased up to 1.9-fold after T3 treatment in HepG2-TRalpha1 cells. Similar findings were obtained in thyroidectomized rats after T3 application. Cycloheximide treatment did not suppress induction of ARA70 transcription by T3, suggesting that this regulation is direct. A series of deletion mutants of ARA70 promoter fragments in pGL2 plasmid were generated to localize the thyroid hormone response element (TRE). The DNA fragments (-234/-190 or +56/+119) gave 1.55- or 2-fold enhanced promoter activity by T3. Thus, two TRE sites exist in the upstream-regulatory region of ARA70. The TR-TRE interaction was further confirmed with EMSAs. Additionally, ARA70 could interfere with TR/TRE complex formation. Therefore, the data indicated that ARA70 suppresses T3 signaling in a TRE-dependent manner. These experimental results suggest that T3 directly up-regulates ARA70 gene expression. Subsequently, ARA70 negatively regulates T3 signaling.

Limits on Arcminute Scale Cosmic Microwave Background Anisotropy with the BIMA Array

NASA Technical Reports Server (NTRS)

Holzapfel, W. L.; Carlstrom, J. E.; Grego, L.; Holder, G. P.; Joy, M. K.; Reese, E. D.; Rose, M. Franklin (Technical Monitor)

2000-01-01

We have used the Berkeley-Illinois-Maryland-Association (BIMA) millimeter array outfitted with sensitive cm-wave receivers to search for Cosmic Microwave Background (CMB) anisotropies on arcminute scales. The interferometer was placed in a compact configuration which produces high brightness sensitivity, while providing discrimination against point sources. Operating at a frequency of 28.5 GHz, the FWHM primary beam of the instrument is 6.6 arcminutes. We have made sensitive images of seven fields, five of which where chosen specifically to have low IR dust contrast and be free of bright radio sources. Additional observations with the Owens Valley Radio Observatory (OVRO) millimeter array were used to assist in the location and removal of radio point sources. Applying a Bayesian analysis to the raw visibility data, we place limits on CMB anisotropy flat-band power Q_flat = 5.6 (+3.0, -5.6) uK and Q_flat < 14.1 uK at 68% and 95% confidence. The sensitivity of this experiment to flat band power peaks at a multipole of l = 5470, which corresponds to an angular scale of approximately 2 arcminutes The most likely value of Q_flat is similar to the level of the expected secondary anisotropies.

A digital-receiver for the MurchisonWidefield Array

NASA Astrophysics Data System (ADS)

Prabu, Thiagaraj; Srivani, K. S.; Roshi, D. Anish; Kamini, P. A.; Madhavi, S.; Emrich, David; Crosse, Brian; Williams, Andrew J.; Waterson, Mark; Deshpande, Avinash A.; Shankar, N. Udaya; Subrahmanyan, Ravi; Briggs, Frank H.; Goeke, Robert F.; Tingay, Steven J.; Johnston-Hollitt, Melanie; R, Gopalakrishna M.; Morgan, Edward H.; Pathikulangara, Joseph; Bunton, John D.; Hampson, Grant; Williams, Christopher; Ord, Stephen M.; Wayth, Randall B.; Kumar, Deepak; Morales, Miguel F.; deSouza, Ludi; Kratzenberg, Eric; Pallot, D.; McWhirter, Russell; Hazelton, Bryna J.; Arcus, Wayne; Barnes, David G.; Bernardi, Gianni; Booler, T.; Bowman, Judd D.; Cappallo, Roger J.; Corey, Brian E.; Greenhill, Lincoln J.; Herne, David; Hewitt, Jacqueline N.; Kaplan, David L.; Kasper, Justin C.; Kincaid, Barton B.; Koenig, Ronald; Lonsdale, Colin J.; Lynch, Mervyn J.; Mitchell, Daniel A.; Oberoi, Divya; Remillard, Ronald A.; Rogers, Alan E.; Salah, Joseph E.; Sault, Robert J.; Stevens, Jamie B.; Tremblay, S.; Webster, Rachel L.; Whitney, Alan R.; Wyithe, Stuart B.

2015-03-01

An FPGA-based digital-receiver has been developed for a low-frequency imaging radio interferometer, the Murchison Widefield Array (MWA). The MWA, located at the Murchison Radio-astronomy Observatory (MRO) in Western Australia, consists of 128 dual-polarized aperture-array elements (tiles) operating between 80 and 300 MHz, with a total processed bandwidth of 30.72 MHz for each polarization. Radio-frequency signals from the tiles are amplified and band limited using analog signal conditioning units; sampled and channelized by digital-receivers. The signals from eight tiles are processed by a single digital-receiver, thus requiring 16 digital-receivers for the MWA. The main function of the digital-receivers is to digitize the broad-band signals from each tile, channelize them to form the sky-band, and transport it through optical fibers to a centrally located correlator for further processing. The digital-receiver firmware also implements functions to measure the signal power, perform power equalization across the band, detect interference-like events, and invoke diagnostic modes. The digital-receiver is controlled by high-level programs running on a single-board-computer. This paper presents the digital-receiver design, implementation, current status, and plans for future enhancements.

Limits on fast radio bursts at 145 MHz with ARTEMIS, a real-time software backend

NASA Astrophysics Data System (ADS)

Karastergiou, A.; Chennamangalam, J.; Armour, W.; Williams, C.; Mort, B.; Dulwich, F.; Salvini, S.; Magro, A.; Roberts, S.; Serylak, M.; Doo, A.; Bilous, A. V.; Breton, R. P.; Falcke, H.; Grießmeier, J.-M.; Hessels, J. W. T.; Keane, E. F.; Kondratiev, V. I.; Kramer, M.; van Leeuwen, J.; Noutsos, A.; Osłowski, S.; Sobey, C.; Stappers, B. W.; Weltevrede, P.

2015-09-01

Fast radio bursts (FRBs) are millisecond radio signals that exhibit dispersion larger than what the Galactic electron density can account for. We have conducted a 1446 h survey for FRBs at 145 MHz, covering a total of 4193 deg2 on the sky. We used the UK station of the low frequency array (LOFAR) radio telescope - the Rawlings Array - accompanied for a majority of the time by the LOFAR station at Nançay, observing the same fields at the same frequency. Our real-time search backend, Advanced Radio Transient Event Monitor and Identification System - ARTEMIS, utilizes graphics processing units to search for pulses with dispersion measures up to 320 cm-3 pc. Previous derived FRB rates from surveys around 1.4 GHz, and favoured FRB interpretations, motivated this survey, despite all previous detections occurring at higher dispersion measures. We detected no new FRBs above a signal-to-noise threshold of 10, leading to the most stringent upper limit yet on the FRB event rate at these frequencies: 29 sky-1 d-1 for five ms-duration pulses above 62 Jy. The non-detection could be due to scatter-broadening, limitations on the volume and time searched, or the shape of FRB flux density spectra. Assuming the latter and that FRBs are standard candles, the non-detection is compatible with the published FRB sky rate, if their spectra follow a power law with frequency (∝ να), with α ≳ +0.1, demonstrating a marked difference from pulsar spectra. Our results suggest that surveys at higher frequencies, including the low frequency component of the Square Kilometre Array, will have better chances to detect, estimate rates and understand the origin and properties of FRBs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Resmi, Lekshmi; Zhang, Bing, E-mail: l.resmi@iist.ac.in

Reverse shock (RS) emission from gamma-ray bursts is an important tool in investigating the nature of the ejecta from the central engine. If the magnetization of the ejecta is not high enough to suppress the RS, a strong RS emission component, usually peaking in the optical/IR band early on, would provide an important contribution to early afterglow light curve. In the radio band, synchrotron self-absorption may suppress early RS emission and also delay the RS peak time. In this paper, we calculate the self-absorbed RS emission in the radio band under different dynamical conditions. In particular, we stress that themore » RS radio emission is subject to self-absorption in both RSs and forward shocks (FSs). We calculate the ratio between the RS to FS flux at the RS peak time for different frequencies, which is a measure of the detectability of the RS emission component. We then constrain the range of physical parameters for a detectable RS, in particular the role of magnetization. We notice that unlike optical RS emission which is enhanced by moderate magnetization, moderately magnetized ejecta do not necessarily produce a brighter radio RS due to the self-absorption effect. For typical parameters, the RS emission component would not be detectable below 1 GHz unless the medium density is very low (e.g., n < 10{sup −3} cm{sup −3} for the interstellar medium and A {sub *} < 5 × 10{sup −4} for wind). These predictions can be tested using the afterglow observations from current and upcoming radio facilities such as the Karl G. Jansky Very Large Array, the Low-Frequency Array, the Five Hundred Meter Aperture Spherical Telescope, and the Square Kilometer Array.« less

Imaging spectroscopy of solar radio burst fine structures.

PubMed

Kontar, E P; Yu, S; Kuznetsov, A A; Emslie, A G; Alcock, B; Jeffrey, N L S; Melnik, V N; Bian, N H; Subramanian, P

2017-11-15

Solar radio observations provide a unique diagnostic of the outer solar atmosphere. However, the inhomogeneous turbulent corona strongly affects the propagation of the emitted radio waves, so decoupling the intrinsic properties of the emitting source from the effects of radio wave propagation has long been a major challenge in solar physics. Here we report quantitative spatial and frequency characterization of solar radio burst fine structures observed with the Low Frequency Array, an instrument with high-time resolution that also permits imaging at scales much shorter than those corresponding to radio wave propagation in the corona. The observations demonstrate that radio wave propagation effects, and not the properties of the intrinsic emission source, dominate the observed spatial characteristics of radio burst images. These results permit more accurate estimates of source brightness temperatures, and open opportunities for quantitative study of the mechanisms that create the turbulent coronal medium through which the emitted radiation propagates.

VLA observations of the supernova remnant Puppus A at 327 and 1515 MHz

NASA Technical Reports Server (NTRS)

Dubner, G. M.; Braun, R.; Winkler, P. F.; Goss, W. M.

1991-01-01

Very Large Array radio images of Puppis A at 327 and 1515 MHz are presented. The observations were performed with the VLA in the C/D and B/C configurations, respectively. The angular resolution is about 77 arcsec x 43 arcsec. The observed radio shell shows signs of interaction between the expanding shock front and the inhomogeneous surrounding medium. An excellent correlation is found between radio and X-ray emission, mainly toward the NE border of the remnant. There is little correspondence between the optical and radio images, suggesting a different origin for the emission. A region of steeper radio spectral index is associated with the highly decelerated eastern periphery.

8. ARAI Shop and maintenance building ARA627 interior view. Remains ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. ARA-I Shop and maintenance building ARA-627 interior view. Remains of cabinetry and electrical switch panel in one of rooms. Ineel photo no. 1-11. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

24. ARAIII Reactor building ARA608 interior. Camera facing south. Chalk ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. ARA-III Reactor building ARA-608 interior. Camera facing south. Chalk marks on wall indicate presence or absence of spot contamination. Ineel photo no. 3-2. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

[Experimental study on aging effect of Angelica sinensis polysaccharides combined with cytarabine on human leukemia KG1alpha cell lines].

PubMed

Xu, Chun-Yan; Geng, Shan; Liu, Jun; Zhu, Jia-Hong; Zhang, Xian-Ping; Jiang, Rong; Wang, Ya-Ping

2014-04-01

The latest findings of our laboratory showed that Angelica sinensis polysaccharide (ASP) showed a definite effect in regulating the aging of hematopoietic stem cells. Leukemia is a type of malignant hematopoietic tumor in hematopoietic stem cells. There have been no relevant reports about ASP's effect in regulating the aging of leukemia cells. In this study, human acute myeloid leukemia (AML) KG1alpha cell lines in logarithmic growth phase were taken as the study object, and were divided into the ASP group, the cytarabine (Ara-C) group, the ASP + Ara-C group and the control group. The groups were respectively treated with different concentration of ASP, Ara-C and ASP + Ara-C for different periods, with the aim to study the effect of ASP combined with Ara-C in regulating the aging of human acute myeloid leukemia KG1alpha cell lines and its relevant mechanism. The results showed that ASP, Ara-C and ASP + Ara-C could obviously inhibit KG1alpha cell proliferation in vitro, block the cells in G0/G1 phase. The cells showed the aging morphological feature. The percentage of positive stained aging cells was dramatically increased, and could significantly up-regulate the expression of aging-related proteins P16 and RB, which were more obvious in the ASP + Ara-C group. In conclusion, the aging mechanism of KG1alpha cell induced by ASP and Ara-C may be related to the regulation of the expression of aging-related proteins, suggesting that the combined administration of ASP and anticancer drugs plays a better role in the treatment of leukemia .

Spot 42 Small RNA Regulates Arabinose-Inducible araBAD Promoter Activity by Repressing Synthesis of the High-Affinity Low-Capacity Arabinose Transporter

PubMed Central

Chen, Jiandong

2016-01-01

ABSTRACT The l-arabinose-inducible araBAD promoter (PBAD) enables tightly controlled and tunable expression of genes of interest in a broad range of bacterial species. It has been used successfully to study bacterial sRNA regulation, where PBAD drives expression of target mRNA translational fusions. Here we report that in Escherichia coli, Spot 42 sRNA regulates PBAD promoter activity by affecting arabinose uptake. We demonstrate that Spot 42 sRNA represses araF, a gene encoding the AraF subunit of the high-affinity low-capacity arabinose transporter AraFGH, through direct base-pairing interactions. We further show that endogenous Spot 42 sRNA is sufficient to repress araF expression under various growth conditions. Finally, we demonstrate this posttranscriptional repression has a biological consequence, decreasing the induction of PBAD at low levels of arabinose. This problem can be circumvented using strategies reported previously for avoiding all-or-none induction behavior, such as through constitutive expression of the low-affinity high-capacity arabinose transporter AraE or induction with a higher concentration of inducers. This work adds araF to the set of Spot 42-regulated genes, in agreement with previous studies suggesting that Spot 42, itself negatively regulated by the cyclic AMP (cAMP) receptor protein-cAMP complex, reinforces the catabolite repression network. IMPORTANCE The bacterial arabinose-inducible system is widely used for titratable control of gene expression. We demonstrate here that a posttranscriptional mechanism mediated by Spot 42 sRNA contributes to the functionality of the PBAD system at subsaturating inducer concentrations by affecting inducer uptake. Our finding extends the inputs into the known transcriptional control for the PBAD system and has implications for improving its usage for tunable gene expression. PMID:27849174

A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis.

PubMed

Codreanu, F; Collignon, O; Roitel, O; Thouvenot, B; Sauvage, C; Vilain, A-C; Cousin, M-O; Decoster, A; Renaudin, J-M; Astier, C; Monnez, J-M; Vallois, P; Morisset, M; Moneret-Vautrin, D-A; Brulliard, M; Ogier, V; Castelain, M-C; Kanny, G; Bihain, B E; Jacquenet, S

2011-01-01

Double-blind placebo-controlled food challenge (DBPCFC) is currently considered the gold standard for peanut allergy diagnosis. However, this procedure that requires the hospitalization of patients, mostly children, in specialized centers for oral exposure to allergens may cause severe reactions requiring emergency measures. Thus, a simpler and safer diagnosis procedure is needed. The aim of this study was to evaluate the diagnostic performance of a new set of in vitro blood tests for peanut allergy. The levels of IgE directed towards peanut extract and recombinant peanut allergens Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 7, and Ara h 8 were measured in 3 groups of patients enrolled at 2 independent centers: patients with proven peanut allergy (n=166); pollen-sensitized subjects without peanut allergy (n=61), and control subjects without allergic disease (n=10). Seventy-nine percent of the pollen-sensitized patients showed IgE binding to peanut, despite their tolerance to peanut. In contrast, combining the results of specific IgE to peanut extract and to recombinant Ara h 2 and Ara h 6 yielded a peanut allergy diagnosis with a 98% sensitivity and an 85% specificity at a positivity threshold of 0.10 kU/l. Use of a threshold of 0.23 kU/l for recombinant Ara h 2 increased specificity (96%) at the cost of sensitivity (93%). A simple blood test can be used to diagnose peanut allergy with a high level of precision. However, DBPCFC will remain useful for the few cases where immunological and clinical observations yield conflicting results. Copyright © 2010 S. Karger AG, Basel.

A National Descriptive Portrait of Adolescent Relationship Abuse: Results From the National Survey on Teen Relationships and Intimate Violence.

PubMed

Taylor, Bruce G; Mumford, Elizabeth A

2016-03-01

This article reports results from the National Survey on Teen Relationships and Intimate Violence (STRiV) for 12- to 18-year-old youth (n = 1,804). STRiV provides the first nationally representative household survey focused on adolescent relationship abuse (ARA), covering perpetration and victimization. Among respondents (37%) reporting current- or past-year dating, 69% reported lifetime ARA victimization (63% lifetime ARA perpetration). Although psychological abuse was most common for these youth (more than 60%), the rates of sexual abuse (18%) and physical abuse victimization (18%), as well as 12% reporting perpetrating physical abuse and/or sexual abuse (12%) were substantial as well. Other than differences by age and gender, ARA rates were consistent by race/ethnicity, geographic region, urbanicity, and household characteristics, highlighting the importance of universal prevention programs. Compared with youth aged 15 to 18, those 12 to 14 years old reported lower rates of psychological and sexual ARA victimization. Similarly, we found lower ARA perpetration rates for those 12 to 14. We found no gender differences for ARA victimization but found that girls perpetrated more physical ARA than boys. Girls aged 15 to 18 reported perpetrating moderate threats/physical violence at more than twice the rate of younger girls and 3 times the rate compared with boys aged 15 to 18; girls aged 15 to 18 reported perpetrating more than 4 times the rate of serious psychological abuse than boys 15 to 18. Finally, these data document the significant positive correlation between ARA victimization and perpetration. Findings suggest that when working with youth in prevention services, interventions should not be designed for monolithic groups of "victims" or "perpetrators." © The Author(s) 2014.

FABP-1 GENE ABLATION IMPACTS BRAIN ENDOCANNABINOID SYSTEM IN MALE MICE

PubMed Central

Martin, Gregory G.; Chung, Sarah; Landrock, Danilo; Landrock, Kerstin K.; Huang, Huan; Dangott, Lawrence J.; Peng, Xiaoxue; Kaczocha, Martin; Seeger, Drew R.; Murphy, Eric J.; Golovko, Mikhail Y.; Kier, Ann B.; Schroeder, Friedhelm

2016-01-01

Liver fatty acid binding protein (FABP1, L-FABP) has high affinity for and enhances uptake of arachidonic acid (ARA, C20:4, n-6) which, when esterified to phospholipids, is the requisite precursor for synthesis of endocannabinoids (EC) such as arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG). The brain derives most of its ARA from plasma, taking up ARA and transporting it intracellularly via cytosolic fatty acid binding proteins (FABPs 3,5, and 7) localized within the brain. In contrast, the much more prevalent cytosolic FABP1 is not detectable in the brain but is instead highly expressed in the liver. Therefore, the possibility that FABP1 outside the central nervous system may regulate brain AEA and 2-AG was examined in wild-type (WT) and FABP1 null (LKO) male mice. LKO increased brain levels of AA-containing EC (AEA, 2-AG), correlating with increased free and total ARA in brain and serum. LKO also increased brain levels of non-ARA that contain potentiating endocannabinoids (EC*) such as OEA, PEA, 2-OG, and 2-PG. Concomitantly, LKO decreased serum total ARA-containing EC, but not non-ARA endocannabinoids. LKO did not elicit these changes in the brain EC and EC* due to compensatory upregulation of brain protein levels of enzymes in EC synthesis (NAPEPLD, DAGLα) or cytosolic EC chaperone proteins (FABPs 3, 5, 7, SCP-2, HSP70), or cannabinoid receptors (CB1, TRVP1). These data show for the first time that the non-CNS fatty acid binding protein FABP1 markedly affected brain levels of both ARA-containing endocannabinoids (AEA, 2-AG) as well as their non-ARA potentiating endocannabinoids. PMID:27167970

Prospects for the Detection of Fast Radio Bursts with the Murchison Widefield Array

NASA Astrophysics Data System (ADS)

Trott, Cathryn M.; Tingay, Steven J.; Wayth, Randall B.

2013-10-01

Fast radio bursts (FRBs) are short timescale (Lt1 s) astrophysical radio signals, presumed to be a signature of cataclysmic events of extragalactic origin. The discovery of six high-redshift events at ~1400 MHz from the Parkes radio telescope suggests that FRBs may occur at a high rate across the sky. The Murchison Widefield Array (MWA) operates at low radio frequencies (80-300 MHz) and is expected to detect FRBs due to its large collecting area (~2500 m2) and wide field-of-view (FOV, ~ 1000 deg2 at ν = 200 MHz). We compute the expected number of FRB detections for the MWA assuming a source population consistent with the reported detections. Our formalism properly accounts for the frequency-dependence of the antenna primary beam, the MWA system temperature, and unknown spectral index of the source population, for three modes of FRB detection: coherent; incoherent; and fast imaging. We find that the MWA's sensitivity and large FOV combine to provide the expectation of multiple detectable events per week in all modes, potentially making it an excellent high time resolution science instrument. Deviations of the expected number of detections from actual results will provide a strong constraint on the assumptions made for the underlying source population and intervening plasma distribution.

105. ARAIII. Interior view of ARA608 highbay pit in 1983 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

105. ARA-III. Interior view of ARA-608 high-bay pit in 1983 modified to contain high-temperature, high-pressure autoclave and furnace test area. Ineel photo no. 81-109. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Gas chromatography-mass spectrometry screening for phytochemical 4-desmethylsterols accumulated during development of Tunisian peanut kernels (Arachis hypogaea L.).

PubMed

Cherif, Aicha O; Trabelsi, Hajer; Ben Messaouda, Mhamed; Kâabi, Belhassen; Pellerin, Isabelle; Boukhchina, Sadok; Kallel, Habib; Pepe, Claude

2010-08-11

4-Desmethylsterols, the main component of the phytosterol fraction, have been analyzed during the development of Tunisian peanut kernels ( Arachis hypogaea L.), Trabelsia (AraT) and Chounfakhi (AraC), which are monocultivar species, and Arbi (AraA), which is a wild species, by gas chromatography-mass spectrometry. Immature wild peanut (AraA) showed the highest contents of beta-sitosterol (554.8 mg/100 g of oil), campesterol (228.6 mg/100 g of oil), and Delta(5)-avenasterol (39.0 mg/100 g of oil) followed by peanut cultivar AraC with beta-sitosterol, campesterol, and Delta(5)-avenasterol averages of 267.7, 92.1, and 28.6 mg/100 g of oil, respectively, and similarly for AraT 309.1, 108.4, and 27.4 mg/100 g of oil, respectively, were found. These results suggest that, in immature stages, phytosterol contents can be important regulator factors for the functional quality of peanut oil for the agro-industry chain from plant to nutraceuticals.

Inhibition of DNA replication in Saccharomyces cerevisiae by araCMP.

PubMed

McIntosh, E M; Kunz, B A; Haynes, R H

1986-01-01

Cytosine arabinoside (araC), a potent inhibitor of DNA replication in mammalian cells, was found to be completely ineffective in Saccharomyces cerevisiae. The 5' monophosphate derivative, araCMP, is toxic and effectively inhibits both nuclear and mitochondrial DNA synthesis in this organism. Although wild-type strains can be inhibited by araCMP, dTMP permeable (tup-) strains were found to be much more sensitive to the analogue. In vivo labelling experiments indicate that araC enters yeast cells; however, it is extensively catabolized by deamination and breakage of the glycosidic bond. In addition, the analogue is not efficiently phosphorylated in S. cerevisiae owing to an apparent lack of deoxynucleoside kinase activity. These results provide further evidence that deoxyribonucleotides can be synthesized only through de novo pathways in this organism. Finally, araCMP was found to be recombinagenic in S. cerevisiae which suggests, together with other previous studies, that, in general, inhibition of DNA synthesis in yeast promotes mitotic recombination events.

Discovering the invisible universe

NASA Astrophysics Data System (ADS)

Friedman, Herbert

1991-02-01

The history of astronomical observations outside the visible range is surveyed in a review for general readers. Consideration is given to Jansky's discovery of cosmic radio emission, the pioneering radio observers of the 1940s, the larger radio telescopes built since 1950, aperture synthesis and the Very Large Array, terrestrial and space VLBI networks, ground-based and satellite observations in the IR band, the discovery and early laboratory characterization of X-rays, and X-ray observations from sounding rockets and satellites. Extensive photographs, drawings, diagrams, and sample images are provided.

Radio astronomy

NASA Technical Reports Server (NTRS)

Kellermann, Kenneth I.; Heeschen, David; Backer, Donald C.; Cohen, Marshall H.; Davis, Michael; Depater, Imke; Deyoung, David; Dulk, George A.; Fisher, J. R.; Goss, W. Miller

1991-01-01

The following subject areas are covered: (1) scientific opportunities (millimeter and sub-millimeter wavelength astronomy; meter to hectometer astronomy; the Sun, stars, pulsars, interstellar masers, and extrasolar planets; the planets, asteroids, and comets; radio galaxies, quasars, and cosmology; and challenges for radio astronomy in the 1990's); (2) recommendations for new facilities (the millimeter arrays, medium scale instruments, and small-scale projects); (3) continuing activities and maintenance, upgrading of telescopes and instrumentation; (4) long range programs and technology development; and (5) social, political, and organizational considerations.

Submm/mm galaxy counterpart identification using a characteristic density distribution

NASA Astrophysics Data System (ADS)

Alberts, Stacey; Wilson, Grant W.; Lu, Yu; Johnson, Seth; Yun, Min S.; Scott, Kimberly S.; Pope, Alexandra; Aretxaga, Itziar; Ezawa, Hajime; Hughes, David H.; Kawabe, Ryohei; Kim, Sungeun; Kohno, Kotaro; Oshima, Tai

2013-05-01

We present a new submm/mm galaxy counterpart identification technique which builds on the use of Spitzer Infrared Array Camera (IRAC) colours as discriminators between likely counterparts and the general IRAC galaxy population. Using 102 radio- and Submillimeter Array-confirmed counterparts to AzTEC sources across three fields [Great Observatories Origins Deep Survey-North, -South and Cosmic Evolution Survey (COSMOS)], we develop a non-parametric IRAC colour-colour characteristic density distribution, which, when combined with positional uncertainty information via likelihood ratios, allows us to rank all potential IRAC counterparts around submillimetre galaxies (SMGs) and calculate the significance of each ranking via the reliability factor. We report all robust and tentative radio counterparts to SMGs, the first such list available for AzTEC/COSMOS, as well as the highest ranked IRAC counterparts for all AzTEC SMGs in these fields as determined by our technique. We demonstrate that the technique is free of radio bias and thus applicable regardless of radio detections. For observations made with a moderate beam size (˜18 arcsec), this technique identifies ˜85 per cent of SMG counterparts. For much larger beam sizes (≳30 arcsec), we report identification rates of 33-49 per cent. Using simulations, we demonstrate that this technique is an improvement over using positional information alone for observations with facilities such as AzTEC on the Large Millimeter Telescope and Submillimeter Common User Bolometer Array 2 on the James Clerk Maxwell Telescope.

Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice.

PubMed

Devalliere, Julie; Dooley, Kevin; Hu, Yong; Kelangi, Sarah S; Uygun, Basak E; Yarmush, Martin L

2017-10-01

Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of increasing their proteolytic resistance, thus their activity in vivo. KGF and ARA290 were fused with elastin-like peptide (ELP), a protein polymer derived from tropoelastin, that confers the ability to separate into a colloidal suspension of liquid-like coacervates. ELP fusion did not diminish peptides activities as demonstrated by ability of KGF-ELP to accelerate keratinocyte proliferation and migration, and ARA290-ELP to protect cells from apoptosis. We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model. In this model, ARA290-ELP was found to accelerate healing, notably by increasing angiogenesis in the wound bed. We further showed that co-delivery of ARA290 and KGF, with the 1:4 KGF-ELP to ARA290-ELP ratio, was the most effective wound treatment with the fastest healing rate, the thicker granulation tissue and regenerated epidermis after 28 days. Overall, this study shows that ARA290-ELP and KGF-ELP constitute promising new therapeutics for treatment of chronic wounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Arachidonic acid production by Mortierella alpina using raw crop materials.

PubMed

Cao, Ganggang; Guan, Zhengbing; Liu, Feixian G; Liao, Xiangru; Cai, Yujie

2015-01-01

Arachidonic acid (ARA) is one of the three essential fatty acids, and it is important for human body to keep healthy and is widely used. At present, expensive materials such as glucose and yeast extract are generally reported to be optimal for ARA production. A new cost-effective fermentation process including cheaper material for ARA production is of great significance. Feasibility of using corn meal and powdered soybean for fungal growth and lipid accumulation was evaluated by means of single factor test. N-hexadecane concentration was optimized, and the effect of temperature on biomass and ARA content was examined. Mortierella alpina made better use of the aforementioned material as carbon and nitrogen sources for both hyphae growth and ARA production compared with glucose and yeast extract. Maximal levels of 10.9 g/L ARA and 26.1 g/L total lipids were obtained when 66 g/L corn meal, 54 g/L soybean meal and 6% (v/v) n-hexadecane were supplemented. A temperature-shift strategy involved three steps, namely, 30°C (3 days) - 25°C (4 days) - 20°C (4 days), which further improved ARA production by 24.7%. Several factors such as carbon and nitrogen sources, temperature and dissolved oxygen had great influence on biomass and microbial oil production. Mortierella alpina preferred corn and soybean meal compared with glucose and yeast extract, which would surely alleviate the high cost of ARA production. Based on this study, the new process is both low cost and practicable.

The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: a diffusion tensor imaging study.

PubMed

Jang, Sung Ho; Kwon, Hyeok Gyu

2015-03-17

The ascending reticular activating system (ARAS) is responsible for regulation of consciousness. Precise evaluation of the ARAS is important for diagnosis and management of patients with impaired consciousness. In the current study, we attempted to reconstruct the portion of the ARAS from the pontine reticular formation (RF) to the hypothalamus in normal subjects, using diffusion tensor imaging (DTI). A total of 31 healthy subjects were recruited for this study. DTI scanning was performed using 1.5-T, and the ARAS from the pontine RF to the hypothalamus was reconstructed. Values of fractional anisotropy, mean diffusivity, and tract volume of the ARAS from the pontine RF to the hypothalamus were measured. In all subjects, the ARAS from the pontine RF to the hypothalamus originated from the RF at the level of the mid-pons, where the trigeminal nerve could be seen, ascended through the periaqueductal gray matter of the midbrain anterolaterally to the anterior commissure level, and then terminated into the hypothalamus. No significant differences in DTI parameters were observed between the left and right hemispheres and between males and females (p<0.05). We identified the ARAS between the pontine RF and the hypothalamus in normal subjects using DTI. We believe that the reconstruction methodology and the results of this study would be useful to clinicians involved in the care of patients with impaired consciousness and researchers in studies of the ARAS. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The Sun Radio Imaging Space Experiment (SunRISE) Mission

NASA Astrophysics Data System (ADS)

Lazio, Joseph; Kasper, Justin; Maksimovic, Milan; Alibay, Farah; Amiri, Nikta; Bastian, Tim; Cohen, Christina; Landi, Enrico; Manchester, Ward; Reinard, Alysha; Schwadron, Nathan; Cecconi, Baptiste; Hallinan, Gregg; Hegedus, Alex; Krupar, Vratislav; Zaslavsky, Arnaud

2017-04-01

Radio emission from coronal mass ejections (CMEs) is a direct tracer of particle acceleration in the inner heliosphere and potential magnetic connections from the lower solar corona to the larger heliosphere. Energized electrons excite Langmuir waves, which then convert into intense radio emission at the local plasma frequency, with the most intense acceleration thought to occur within 20 RS. The radio emission from CMEs is quite strong such that only a relatively small number of antennas is required to detect and map it, but many aspects of this particle acceleration and transport remain poorly constrained. Ground-based arrays would be quite capable of tracking the radio emission associated with CMEs, but absorption by the Earth's ionosphere limits the frequency coverage of ground-based arrays (ν ≳ 15 MHz), which in turn limits the range of solar distances over which they can track the radio emission (≲ 3RS). The state-of-the-art for tracking such emission from space is defined by single antennas (Wind/WAVES, Stereo/SWAVES), in which the tracking is accomplished by assuming a frequency-to-density mapping; there has been some success in triangulating the emission between the spacecraft, but considerable uncertainties remain. We describe the Sun Radio Imaging Space Experiment (SunRISE) mission concept: A constellation of small spacecraft in a geostationary graveyard orbit designed to localize and track radio emissions in the inner heliosphere. Each spacecraft would carry a receiving system for observations below 25 MHz, and SunRISE would produce the first images of CMEs more than a few solar radii from the Sun. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

Compact radio sources in the starburst galaxy M82 and the Sigma-D relation for supernova remnants

NASA Technical Reports Server (NTRS)

Huang, Z. P.; Thuan, T. X.; Chevalier, R. A.; Condon, J. J.; Yin, Q. F.

1994-01-01

We have obtained an 8.4 GHz Very Large Array (VLA) A-array map of the starburst galaxy M82 with a resolution Full Width at Half Maximum (FWHM) approximately 0.182 sec. About 50 compact radio sources in the central region of M82 were detected with a peak surface brightness approximately greater than 10(exp -17) W/Hz/sq m/sr. Comparison with previous observations shows that most sources are declining in flux. Three previously visible sources have faded into the background of our map (approximately less than 0.2 mJy/beam), while a few sources, including the second and third brightest radio sources in M82, may have increased slightly in flux over the last decade. No new radio supernova was found. The birth rate of the compact radio sources is estimated to be 0.11 + or - 0.05/yr. We attribute the population of such bright, small supernova remnants (SNRs) in M82 to the high pressure in the central region that can truncate the mass loss during a red supergiant phase or allow dense ionized clouds to be present. The compact radio sources obey a Sigma(radio surface brightness) - D(diameter) relation which is remarkably similar to that followed by supernova remnants in the Galaxy and the Magellanic Clouds and by two of the strongest known extragalactic radio supernovae: SN 1986J and SN 1979C. A least-squares fit to the SNR data gives: Sigma(sub 8.4 GHz) (W/Hz/sq m/sr) = 4.4 x 10(exp -16) D(sub pc)(exp -3.5 +/- 0.1) covering seven orders of magnitude in Sigma. Possible selection effects are discussed and a theoretical discussion of the correlation is presented.

The Sun Radio Imaging Space Experiment (SunRISE) Mission

NASA Astrophysics Data System (ADS)

Kasper, J. C.; Lazio, J.; Alibay, F.; Amiri, N.; Bastian, T.; Cohen, C.; Landi, E.; Hegedus, A. M.; Maksimovic, M.; Manchester, W.; Reinard, A.; Schwadron, N.; Cecconi, B.; Hallinan, G.; Krupar, V.

2017-12-01

Radio emission from coronal mass ejections (CMEs) is a direct tracer of particle acceleration in the inner heliosphere and potential magnetic connections from the lower solar corona to the larger heliosphere. Energized electrons excite Langmuir waves, which then convert into intense radio emission at the local plasma frequency, with the most intense acceleration thought to occur within 20 R_S. The radio emission from CMEs is quite strong such that only a relatively small number of antennas is required to detect and map it, but many aspects of this particle acceleration and transport remain poorly constrained. Ground-based arrays would be quite capable of tracking the radio emission associated with CMEs, but absorption by the Earth's ionosphere limits the frequency coverage of ground-based arrays (nu > 15 MHz), which in turn limits the range of solar distances over which they can track the radio emission (< 3 R_S). The state-of-the-art for tracking such emission from space is defined by single antennas (Wind/WAVES, Stereo/SWAVES), in which the tracking is accomplished by assuming a frequency-to-density mapping; there has been some success in triangulating the emission between the spacecraft, but considerable uncertainties remain. We describe the Sun Radio Imaging Space Experiment (SunRISE) mission concept: A constellation of small spacecraft in a geostationary graveyard orbit designed to localize and track radio emissions in the inner heliosphere. Each spacecraft would carry a receiving system for observations below 25 MHz, and SunRISE would produce the first images of CMEs more than a few solar radii from the Sun. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

Searching for giga-Jansky fast radio bursts from the Milky Way with a global array of low-cost radio receivers

NASA Astrophysics Data System (ADS)

Maoz, Dan; Loeb, Abraham

2017-06-01

If fast radio bursts (FRBs) originate from galaxies at cosmological distances, then their all-sky rate implies that the Milky Way may host an FRB every 30-1500 yr, on average. If many FRBs persistently repeat for decades or more, a local giant FRB could be active now, with 1 GHz radio pulses of flux ˜3 × 1010 Jy, comparable with the fluxes and frequencies detectable by cellular communication devices (cell phones, Wi-Fi and GPS). We propose searching for Galactic FRBs using a global array of low-cost radio receivers. One possibility is the ˜1 GHz communication channel in cellular phones, through a Citizens-Science downloadable application. Participating phones would continuously listen for and record candidate FRBs and would periodically upload information to a central data-processing website which will identify the signature of a real, globe-encompassing, FRB from an astronomical distance. Triangulation of the GPS-based pulse arrival times reported from different Earth locations will provide the FRB sky position, potentially to arcsecond accuracy. Pulse arrival times versus frequency, from reports from phones operating at diverse frequencies, or from fast signal de-dispersion by the application, will yield the dispersion measure (DM). Compared to a Galactic DM model, it will indicate the source distance within the Galaxy. A variant approach uses the built-in ˜100 MHz FM-radio receivers present in cell phones for an FRB search at lower frequencies. Alternatively, numerous 'software-defined radio' devices, costing ˜$10 US each, could be deployed and plugged into USB ports of personal computers (particularly in radio-quiet locations) to establish the global network of receivers.

LOFAR reveals the giant: a low-frequency radio continuum study of the outflow in the nearby FR I radio galaxy 3C 31

NASA Astrophysics Data System (ADS)

Heesen, V.; Croston, J. H.; Morganti, R.; Hardcastle, M. J.; Stewart, A. J.; Best, P. N.; Broderick, J. W.; Brüggen, M.; Brunetti, G.; ChyŻy, K. T.; Harwood, J. J.; Haverkorn, M.; Hess, K. M.; Intema, H. T.; Jamrozy, M.; Kunert-Bajraszewska, M.; McKean, J. P.; Orrú, E.; Röttgering, H. J. A.; Shimwell, T. W.; Shulevski, A.; White, G. J.; Wilcots, E. M.; Williams, W. L.

2018-03-01

We present a deep, low-frequency radio continuum study of the nearby Fanaroff-Riley class I (FR I) radio galaxy 3C 31 using a combination of LOw Frequency ARray (LOFAR; 30-85 and 115-178 MHz), Very Large Array (VLA; 290-420 MHz), Westerbork Synthesis Radio Telescope (WSRT; 609 MHz) and Giant Metre Radio Telescope (GMRT; 615 MHz) observations. Our new LOFAR 145-MHz map shows that 3C 31 has a largest physical size of 1.1 Mpc in projection, which means 3C 31 now falls in the class of giant radio galaxies. We model the radio continuum intensities with advective cosmic ray transport, evolving the cosmic ray electron population and magnetic field strength in the tails as functions of distance to the nucleus. We find that if there is no in situ particle acceleration in the tails, then decelerating flows are required that depend on radius r as v∝rβ (β ≈ -1). This then compensates for the strong adiabatic losses due to the lateral expansion of the tails. We are able to find self-consistent solutions in agreement with the entrainment model of Croston & Hardcastle, where the magnetic field provides ≈1/3 of the pressure needed for equilibrium with the surrounding intracluster medium. We obtain an advective time-scale of ≈190 Myr, which, if equated to the source age, would require an average expansion Mach number M ≈ 5 over the source lifetime. Dynamical arguments suggest that instead either the outer tail material does not represent the oldest jet plasma or else the particle ages are underestimated due to the effects of particle acceleration on large scales.

System-Level Performance of Antenna Arrays in CDMA-Based Cellular Mobile Radio Systems

NASA Astrophysics Data System (ADS)

Czylwik, Andreas; Dekorsy, Armin

2004-12-01

Smart antennas exploit the inherent spatial diversity of the mobile radio channel, provide an antenna gain, and also enable spatial interference suppression leading to reduced intracell as well as intercell interference. Especially, for the downlink of future CDMA-based mobile communications systems, transmit beamforming is seen as a well-promising smart antenna technique. The main objective of this paper is to study the performance of diverse antenna array topologies when applied for transmit beamforming in the downlink of CDMA-based networks. In this paper, we focus on uniform linear array (ULA) and uniform circular array (UCA) topologies. For the ULA, we consider three-sector base stations with one linear array per sector. While recent research on downlink beamforming is often restricted to one single cell, this study takes into account the important impact of intercell interference on the performance by evaluating complete networks. Especially, from the operator perspective, system capacity and system coverage are very essential parameters of a cellular system so that there is a clear necessity of intensive system level investigations. Apart from delivering assessments on the performance of the diverse antenna array topologies, in the paper also different antenna array parameters, such as element spacing and beamwidth of the sector antennas, are optimized. Although we focus on the network level, fast channel fluctuations are taken into account by including them analytically into the signal-to-interference calculation.

146. ARAIII Control building (ARA607) Roof plan and details. Aerojetgeneral ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

146. ARA-III Control building (ARA-607) Roof plan and details. Aerojet-general 880-area/GCRE-607-A-3. Date: February 1958. Ineel index code no. 063-0607-00-013-102548. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Weak-signal Phase Calibration Strategies for Large DSN Arrays

NASA Technical Reports Server (NTRS)

Jones, Dayton L.

2005-01-01

The NASA Deep Space Network (DSN) is studying arrays of large numbers of small, mass-produced radio antennas as a cost-effective way to increase downlink sensitivity and data rates for future missions. An important issue for the operation of large arrays is the accuracy with which signals from hundreds of small antennas can be combined. This is particularly true at Ka band (32 GHz) where atmospheric phase variations can be large and rapidly changing. A number of algorithms exist to correct the phases of signals from individual antennas in the case where a spacecraft signal provides a useful signal-to-noise ratio (SNR) on time scales shorter than the atmospheric coherence time. However, for very weak spacecraft signals it will be necessary to rely on background natural radio sources to maintain array phasing. Very weak signals could result from a spacecraft emergency or by design, such as direct-to-Earth data transmissions from distant planetary atmospheric or surface probes using only low gain antennas. This paper considers the parameter space where external real-time phase calibration will be necessary, and what this requires in terms of array configuration and signal processing. The inherent limitations of this technique are also discussed.

Microwave amplification based on quasiparticle SIS up and down frequency converters

NASA Astrophysics Data System (ADS)

Kojima, T.; Uzawa, Y.; Shan, W.

2018-02-01

Heterodyne instruments have recently attained quantum-limited low-noise performance, particularly in radio astronomy, but it is difficult to develop large heterodyne arrays such as a modern radio camera using cryogenic sensitive detectors based on microwave kinetic inductance detectors, transition edge sensors, etc. In the realization of the heterodyne array, the reduction of power dissipation for semiconductor-based amplifiers remains a major challenge. Alternatively, superconducting parametric amplifiers still seem to have several barriers to application, especially in terms of operating temperature. Here, we show a novel concept of microwave amplification based on up and down frequency-conversion processes using quasiparticle superconductor-insulator-superconductor (SIS) tunnel junctions. We demonstrate positive gain using a proof-of-concept test module, which operates with a power dissipation of several μW at a bath temperature of 4 K. The performance of the module suggests great potential for application in large arrays.

Long-term monitoring of Sgr A* at 7 mm with VERA and KaVA

NASA Astrophysics Data System (ADS)

Akiyama, K.; Kino, M.; Sohn, B.; Lee, S.; Trippe, S.; Honma, M.

2014-05-01

We present the results of radio monitoring observations of Sgr A* at 7 mm (i.e. 43 GHz) with the VLBI Exploration of Radio Astrometry (VERA), which is a VLBI array in Japan. VERA provides angular resolution on millisecond scales, resolving structures within 100 Schwarzschild radii of Sgr A* , similar to the Very Large Baseline Array (VLBA). We performed multi-epoch observations of Sgr A* in 2005 - 2008, and started monitoring it again with VERA from 2013 January to trace the current G2 encounter event. Our preliminary results in 2013 show that Sgr A* on mas scales has been in an ordinary state as of August 2013, although some fraction of the G2 cloud already passed the pericenter of Sgr A* in April 2013. We will continue monitoring Sgr A* with VERA and the newly developed KaVA (KVN and VERA Array).

Mechanically Reconfigurable Single-Arm Spiral Antenna Array for Generation of Broadband Circularly Polarized Orbital Angular Momentum Vortex Waves.

PubMed

Li, Long; Zhou, Xiaoxiao

2018-03-23

In this paper, a mechanically reconfigurable circular array with single-arm spiral antennas (SASAs) is designed, fabricated, and experimentally demonstrated to generate broadband circularly polarized orbital angular momentum (OAM) vortex waves in radio frequency domain. With the symmetrical and broadband properties of single-arm spiral antennas, the vortex waves with different OAM modes can be mechanically reconfigurable generated in a wide band from 3.4 GHz to 4.7 GHz. The prototype of the circular array is proposed, conducted, and fabricated to validate the theoretical analysis. The simulated and experimental results verify that different OAM modes can be effectively generated by rotating the spiral arms of single-arm spiral antennas with corresponding degrees, which greatly simplify the feeding network. The proposed method paves a reconfigurable way to generate multiple OAM vortex waves with spin angular momentum (SAM) in radio and microwave satellite communication applications.

Nanosecond-level time synchronization of autonomous radio detector stations for extensive air showers

NASA Astrophysics Data System (ADS)

The Pierre Auger Collaboration

2016-01-01

To exploit the full potential of radio measurements of cosmic-ray air showers at MHz frequencies, a detector timing synchronization within 1 ns is needed. Large distributed radio detector arrays such as the Auger Engineering Radio Array (AERA) rely on timing via the Global Positioning System (GPS) for the synchronization of individual detector station clocks. Unfortunately, GPS timing is expected to have an accuracy no better than about 5 ns. In practice, in particular in AERA, the GPS clocks exhibit drifts on the order of tens of ns. We developed a technique to correct for the GPS drifts, and an independent method is used to cross-check that indeed we reach a nanosecond-scale timing accuracy by this correction. First, we operate a ``beacon transmitter'' which emits defined sine waves detected by AERA antennas recorded within the physics data. The relative phasing of these sine waves can be used to correct for GPS clock drifts. In addition to this, we observe radio pulses emitted by commercial airplanes, the position of which we determine in real time from Automatic Dependent Surveillance Broadcasts intercepted with a software-defined radio. From the known source location and the measured arrival times of the pulses we determine relative timing offsets between radio detector stations. We demonstrate with a combined analysis that the two methods give a consistent timing calibration with an accuracy of 2 ns or better. Consequently, the beacon method alone can be used in the future to continuously determine and correct for GPS clock drifts in each individual event measured by AERA.

Nanosecond-level time synchronization of autonomous radio detector stations for extensive air showers

DOE PAGES

Aab, Alexander

2016-01-29

To exploit the full potential of radio measurements of cosmic-ray air showers at MHz frequencies, a detector timing synchronization within 1 ns is needed. Large distributed radio detector arrays such as the Auger Engineering Radio Array (AERA) rely on timing via the Global Positioning System (GPS) for the synchronization of individual detector station clocks. Unfortunately, GPS timing is expected to have an accuracy no better than about 5 ns. In practice, in particular in AERA, the GPS clocks exhibit drifts on the order of tens of ns. We developed a technique to correct for the GPS drifts, and an independentmore » method used for cross-checks that indeed we reach nanosecond-scale timing accuracy by this correction. First, we operate a “beacon transmitter” which emits defined sine waves detected by AERA antennas recorded within the physics data. The relative phasing of these sine waves can be used to correct for GPS clock drifts. In addition to this, we observe radio pulses emitted by commercial airplanes, the position of which we determine in real time from Automatic Dependent Surveillance Broadcasts intercepted with a software-defined radio. From the known source location and the measured arrival times of the pulses we determine relative timing offsets between radio detector stations. We demonstrate with a combined analysis that the two methods give a consistent timing calibration with an accuracy of 2 ns or better. Consequently, the beacon method alone can be used in the future to continuously determine and correct for GPS clock drifts in each individual event measured by AERA.« less

JPL Big Data Technologies for Radio Astronomy

NASA Astrophysics Data System (ADS)

Jones, Dayton L.; D'Addario, L. R.; De Jong, E. M.; Mattmann, C. A.; Rebbapragada, U. D.; Thompson, D. R.; Wagstaff, K.

2014-04-01

During the past three years the Jet Propulsion Laboratory has been working on several technologies to deal with big data challenges facing next-generation radio arrays, among other applications. This program has focused on the following four areas: 1) We are investigating high-level ASIC architectures that reduce power consumption for cross-correlation of data from large interferometer arrays by one to two orders of magnitude. The cost of operations for the Square Kilometre Array (SKA), which may be dominated by the cost of power for data processing, is a serious concern. A large improvement in correlator power efficiency could have a major positive impact. 2) Data-adaptive algorithms (machine learning) for real-time detection and classification of fast transient signals in high volume data streams are being developed and demonstrated. Studies of the dynamic universe, particularly searches for fast (<< 1 second) transient events, require that data be analyzed rapidly and with robust RFI rejection. JPL, in collaboration with the International Center for Radio Astronomy Research in Australia, has developed a fast transient search system for eventual deployment on ASKAP. In addition, a real-time transient detection experiment is now running continuously and commensally on NRAO's Very Long Baseline Array. 3) Scalable frameworks for data archiving, mining, and distribution are being applied to radio astronomy. A set of powerful open-source Object Oriented Data Technology (OODT) tools is now available through Apache. OODT was developed at JPL for Earth science data archives, but it is proving to be useful for radio astronomy, planetary science, health care, Earth climate, and other large-scale archives. 4) We are creating automated, event-driven data visualization tools that can be used to extract information from a wide range of complex data sets. Visualization of complex data can be improved through algorithms that detect events or features of interest and autonomously generate images or video to display those features. This work has been carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

123. ARAI Substation (ARA726) plan, elevation, security fence details, and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

123. ARA-I Substation (ARA-726) plan, elevation, security fence details, and sections. Norman Engineering Company 961-area/SF-726-E-1. Date: January 1959. Ineel index code no. 068-0726-10-613-102778. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

144. ARAIII Control building (ARA607) Foundation plan. Aerojetgeneral 880area/GCRE607S1. Date: ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

144. ARA-III Control building (ARA-607) Foundation plan. Aerojet-general 880-area/GCRE-607-S-1. Date: February 1958. Ineel index code no. 063-0607-60-013-102568. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

87. ARAIII. GCRE reactor building (ARA608) Mechanical equipment room. Utility ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

87. ARA-III. GCRE reactor building (ARA-608) Mechanical equipment room. Utility air receiver, dryer, and compressor sit on their foundations prior to grouting. December 22, 1958. Ineel photo no. 58-6429. Photographer: Ken Mansfield. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

157. ARAIII Reactor building (ARA608) Main gas loop mechanical flow ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

157. ARA-III Reactor building (ARA-608) Main gas loop mechanical flow sheet. This drawing was selected as a typical example of mechanical arrangements within reactor building. Aerojet-general 880-area/GCRE-0608-50-013-102634. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

154. ARAIII Reactor building (ARA608) Foundation sections and details. Shows ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

154. ARA-III Reactor building (ARA-608) Foundation sections and details. Shows profiles of pits. Aerojet-general 888-area/GCRE-608-S-2. Date: February 1958. Ineel index code no. 062-0608-60-013-102654. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

153. ARAIII Reactor building (ARA608) Foundation plan. Aerojetgeneral 880area/GCRE608S1. Date: ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

153. ARA-III Reactor building (ARA-608) Foundation plan. Aerojet-general 880-area/GCRE-608-S-1. Date: February 1958. Ineel index code no. 063-0608-60-013-102653. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

152. ARAIII Reactor building (ARA608) Details of heater and piping ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

152. ARA-III Reactor building (ARA-608) Details of heater and piping pits, including instrumentation plan. Aerojet-general 880-area/GCRE-608-T-18. Date: November 1958. Ineel index code no. 063-0608-25-013-102677. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

149. ARAIII Reactor building (ARA608) Exterior elevations, showing north, south, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

149. ARA-III Reactor building (ARA-608) Exterior elevations, showing north, south, east, and west. Aerojet-general 880-area/GCRE-608-A-6. Date: February 1958. Ineel index code no. 063-0608-00-013-102615. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

151. ARAIII Reactor building (ARA608) Details of reactor pit and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

151. ARA-III Reactor building (ARA-608) Details of reactor pit and instrument plan. Aerojet-general 880-area/GCRE-608-T-19. Date: November 1958. Ineel index code no. 063-0608-25-013-102678. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Medical therapy is best for atherosclerotic renal artery stenosis: Arguments for.

PubMed

Annigeri, R A

2012-01-01

Atherosclerotic renal artery stenosis (ARAS) is a common condition that causes hypertension and reduction in the glomerular filtration rate and is an independent risk factor for death. Despite high technical success, the clinical benefit of renal artery (RA) angioplasty with stenting in ARAS remains doubtful. The published randomized clinical trials provide no support for the notion that renal angioplasty with stenting significantly improves blood pressure, preserves renal function, or reduces episodes of congestive heart failure in patients with ARAS. RA stenting is associated with procedure-related morbidity and mortality. Agents to block the renin-angiotensin-aldosterone system improve outcome and should be a part of a multifaceted medical regimen in ARAS. Medical therapy effectively controls atherosclerotic renovascular disease at all levels of vasculature and hence is the best therapy for ARAS.

Storage and computationally efficient permutations of factorized covariance and square-root information arrays

NASA Technical Reports Server (NTRS)

Muellerschoen, R. J.

1988-01-01

A unified method to permute vector stored Upper triangular Diagonal factorized covariance and vector stored upper triangular Square Root Information arrays is presented. The method involves cyclic permutation of the rows and columns of the arrays and retriangularization with fast (slow) Givens rotations (reflections). Minimal computation is performed, and a one dimensional scratch array is required. To make the method efficient for large arrays on a virtual memory machine, computations are arranged so as to avoid expensive paging faults. This method is potentially important for processing large volumes of radio metric data in the Deep Space Network.

Structural studies of the carbohydrate moieties of lectins from potato (Solanum tuberosum) tubers and thorn-apple (Datura stramonium) seeds

PubMed Central

Ashford, David; Desai, Nila N.; Allen, Anthony K.; Neuberger, Albert; O'Neill, Malcolm A.; Selvendran, Robert R.

1982-01-01

1. Methylation analysis of potato (Solanum tuberosum) lectin and thorn-apple (Datura stramonium) lectin confirmed previous conclusions that both glycoproteins contained high proportions of l-arabinofuranosides and lesser amounts of d-galactopyranosides. The arabinofuranosides are present in both lectins as short unbranched chains containing 1→2- and 1→3-linkages, which are known to be linked to hydroxyproline. Galactopyranosides are present as monosaccharides, which are known to be attached to serine, in potato lectin and as both the monosaccharide and the 1→3-linked disaccharide in Datura lectin. 2. Alkaline digestion of potato lectin and subsequent separation of the components by gel filtration led to the isolation of four fractions corresponding to the mono-, di-, tri- and tetra-arabinosides of hydroxyproline. The latter two fractions accounted for over 70% of the total hydroxyproline. 3. Methylation analysis was used to show that the triarabinoside contained only 1→2-linkages between sugars, but that the tetra-arabinoside contained both 1→2- and 1→3-linkages. Direct-insertion mass spectrometry of these compounds using electron impact and chemical ionization, in a comparison with other known structural patterns, was used to determine the sequences of the sugars, which were Araƒ1→2Araƒ1→2Araƒ1→Hyp and Araƒ1→3Araƒ1→2Araƒ1→2Araƒ 1→Hyp. 4. On the basis of optical rotation it had previously been suggested [Allen, Desai, Neuberger & Creeth (1978) Biochem. J. 171, 665–674] that all the arabinose of potato lectin was present as the β-l-furanoside. However, measurement of the optical rotations of the hydroxyprolyl arabinosides showed that whereas the diarabinoside had a molar rotation ([m]) value close to that predicted, the triarabinoside was more dextrorotatory and the tetra-arabinoside was less dextrorotatory than expected. Possible explanations for these findings are that, although the di- and tri-arabinosides contain exclusively β-arabinofuranosides, in the tri-arabinoside, interactions between pentose units lead to an enhanced positive rotation. The tetra-arabinoside, however, is proposed to contain a single α-arabinofuranoside residue, which is responsible for the lower than expected positive rotation. The observed rotation of the tetra-arabinoside was found to be close to the theoretical value predicted on that basis. Furthermore, the action of a specific α-arabinofuranosidase on the tetrasaccharide was to remove a single arabinose residue, presumably the terminal non-reducing sugar, and to produce a product that was indistinguishable on electrophoresis from the triarabinoside. Changes in rotation were compatible with this assumption. 5. It is concluded that the structures of the hydroxyprolyl tri- and tetra-arabinosides of potato lectin are: βAraƒ1→2βAraƒ1→2βAraƒ1→Hyp and αAraƒ1→3βAraƒ1→2βAraƒ 1→2βAraƒ1→Hyp. These are identical with compounds that have been isolated from the insoluble hydroxyproline-rich glycoproteins of plant cell walls. PMID:7082284

Hardware Architecture Study for NASA's Space Software Defined Radios

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.; Scardelletti, Maximilian C.; Mortensen, Dale J.; Kacpura, Thomas J.; Andro, Monty; Smith, Carl; Liebetreu, John

2008-01-01

This study defines a hardware architecture approach for software defined radios to enable commonality among NASA space missions. The architecture accommodates a range of reconfigurable processing technologies including general purpose processors, digital signal processors, field programmable gate arrays (FPGAs), and application-specific integrated circuits (ASICs) in addition to flexible and tunable radio frequency (RF) front-ends to satisfy varying mission requirements. The hardware architecture consists of modules, radio functions, and and interfaces. The modules are a logical division of common radio functions that comprise a typical communication radio. This paper describes the architecture details, module definitions, and the typical functions on each module as well as the module interfaces. Trade-offs between component-based, custom architecture and a functional-based, open architecture are described. The architecture does not specify the internal physical implementation within each module, nor does the architecture mandate the standards or ratings of the hardware used to construct the radios.

Concept and Analysis of a Satellite for Space-Based Radio Detection of Ultra-High Energy Cosmic Rays

NASA Astrophysics Data System (ADS)

Romero-Wolf, Andrew; Gorham, P.; Booth, J.; Chen, P.; Duren, R. M.; Liewer, K.; Nam, J.; Saltzberg, D.; Schoorlemmer, H.; Wissel, S.; Zairfian, P.

2014-01-01

We present a concept for on-orbit radio detection of ultra-high energy cosmic rays (UHECRs) that has the potential to provide collection rates of ~100 events per year for energies above 10^20 eV. The synoptic wideband orbiting radio detector (SWORD) mission's high event statistics at these energies combined with the pointing capabilities of a space-borne antenna array could enable charged particle astronomy. The detector concept is based on ANITA's successful detection UHECRs where the geosynchrotron radio signal produced by the extended air shower is reflected off the Earth's surface and detected in flight.

Division x: Radio Astronomy

NASA Astrophysics Data System (ADS)

Taylor, Russ; Chapman, Jessica; Rendong, Nan; Carilli, Christopher; Giovannini, Gabriele; Hills, Richard; Hirabayashi, Hisashi; Jonas, Justin; Lazio, Joseph; Morganti, Raffaella; Rubio, Monica; Shastri, Prajval

2012-04-01

This triennium has seen a phenomenal investment in development of observational radio astronomy facilities in all parts of the globe at a scale that significantly impacts the international community. This includes both major enhancements such as the transition from the VLA to the EVLA in North America, and the development of new facilities such as LOFAR, ALMA, FAST, and Square Kilometre Array precursor telescopes in Australia and South Africa. These developments are driven by advances in radio-frequency, digital and information technologies that tremendously enhance the capabilities in radio astronomy. These new developments foreshadow major scientific advances driven by radio observations in the next triennium. We highlight these facility developments in section 3 of this report. A selection of science highlight from this triennium are summarized in section 2.

VLF Radio Wave Propagation Across the Day/Night Terminator

NASA Astrophysics Data System (ADS)

Burch, H.; Moore, R. C.

2016-12-01

In May 2016, a new array of VLF radio receivers was deployed spanning the East Coast of the United States. We present preliminary observations from the array, which was designed in part to track the propagation of the narrowband VLF transmitter signal, NAA (24.0 kHz), down the coast from Cutler, Maine. Amplitude, phase, and polarization observations are compared over multiple days and at different times of year to investigate the dependence of VLF propagation characteristics on solar zenith angle. Measurements are compared to simulations using the Long Wave Propagation Capability code (LWPC) in order to evaluate the accuracy of LWPC's built-in ionosphere model. Efforts to improve the ionosphere model based on observations are discussed.

Study of Microwave Radiation from the Electron Beam at the Telescope Array Site

NASA Astrophysics Data System (ADS)

Ikeda, Daisuke; Gaïor, Romain; Mase, Keiichi; Shin, Bokkyun; De Vries, Krijn; Yamamoto, Tokonatsu; Ishihara, Aya; Kuwabara, Takao; Yoshida, Shigeru; Shibata, Tatsunobu; Ohta, Izumi S.; Ogio, Shoichi; Fukushima, Masaki; Sagawa, Hiroyuki; Matthews, John N.; Thomson, Gordon B.; Hanson, Kael; Meures, Thomas; Murchadha, Aongus Ó.

The Telescope Array (TA) experiment installed the electron accelerator in order to calibrate the fluorescence detector by shooting 40 MeV electrons into the atmosphere. This accelerator also works to investigate the radio detection techniques used for the cosmic ray observations. Using this accelerator, four experimental groups have studied individual radio detection methods at different frequency bands ranging from 50 MHz to 12 GHz. All of these experiments have observed the microwave radiation from the electron beam itself. We have studied the radiation by combining all the measured results and constructed a model of this phenomena. Results of four experiments and model expectation are in good agreement within the systematic uncertainty.

Highlighting the history of Japanese radio astronomy. 4: early solar research in Osaka

NASA Astrophysics Data System (ADS)

Orchiston, Wayne; Nakamura, Tsuko; Ishiguro, Masato

2016-12-01

For about two years, from late 1949, Minoru Oda and Tatsuo Takakura carried out solar observations from Osaka, initially with a hand-made horn and later with a small parabolic antenna connected to a 3.3 GHz receiver, but they only published one short paper on this work. At about the same time, Ojio and others at Osaka City University presented the concept of a solar grating array at a meeting of the Japan Physical Society, but this was never built. In this paper, we provide brief biographical accounts of Oda and Takakura before examining their radio telescopes and the observations that they made. We also briefly discuss the proposed Japanese solar grating array.

Use of specific peptide biomarkers for quantitative confirmation of hidden allergenic peanut proteins Ara h 2 and Ara h 3/4 for food control by liquid chromatography-tandem mass spectrometry.

PubMed

Careri, M; Costa, A; Elviri, L; Lagos, J-B; Mangia, A; Terenghi, M; Cereti, A; Garoffo, L Perono

2007-11-01

A liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS-MS) method based on the detection of biomarker peptides from allergenic proteins was devised for confirming and quantifying peanut allergens in foods. Peptides obtained from tryptic digestion of Ara h 2 and Ara h 3/4 proteins were identified and characterized by LC-MS and LC-MS-MS with a quadrupole-time of flight mass analyzer. Four peptides were chosen and investigated as biomarkers taking into account their selectivity, the absence of missed cleavages, the uniform distribution in the Ara h 2 and Ara h 3/4 protein isoforms together with their spectral features under ESI-MS-MS conditions, and good repeatability of LC retention time. Because of the different expression levels, the selection of two different allergenic proteins was proved to be useful in the identification and univocal confirmation of the presence of peanuts in foodstuffs. Using rice crisp and chocolate-based snacks as model food matrix, an LC-MS-MS method with triple quadrupole mass analyzer allowed good detection limits to be obtained for Ara h 2 (5 microg protein g(-1) matrix) and Ara h 3/4 (1 microg protein g(-1) matrix). Linearity of the method was established in the 10-200 microg g(-1) range of peanut proteins in the food matrix investigated. Method selectivity was demonstrated by analyzing tree nuts (almonds, pecan nuts, hazelnuts, walnuts) and food ingredients such as milk, soy beans, chocolate, cornflakes, and rice crisp.

Transient postnatal fluoxetine leads to decreased brain arachidonic acid metabolism and cytochrome P450 4A in adult mice.

PubMed

Ramadan, Epolia; Blanchard, Helene; Cheon, Yewon; Fox, Meredith A; Chang, Lisa; Chen, Mei; Ma, Kaizong; Rapoport, Stanley I; Basselin, Mireille

2014-05-01

Fetal and perinatal exposure to selective serotonin (5-HT) reuptake inhibitors (SSRIs) has been reported to alter childhood behavior, while transient early exposure in rodents is reported to alter their behavior and decrease brain extracellular 5-HT in adulthood. Since 5-HT2A/2C receptor-mediated neurotransmission can involve G-protein coupled activation of cytosolic phospholipase A2 (cPLA2), releasing arachidonic acid (ARA) from synaptic membrane phospholipid, we hypothesized that transient postnatal exposure to fluoxetine would alter brain ARA metabolism in adult mice. Brain ARA incorporation coefficients k* and rates Jin were quantitatively imaged following intravenous [1-(14)C]ARA infusion of unanesthetized adult mice that had been injected daily with fluoxetine (10mg/kg i.p.) or saline during postnatal days P4-P21. Expression of brain ARA metabolic enzymes and other relevant markers also was measured. On neuroimaging, k* and Jin was decreased widely in early fluoxetine- compared to saline-treated adult mice. Of the enzymes measured, cPLA2 activity was unchanged, while Ca(2+)-independent iPLA2 activity was increased. There was a significant 74% reduced protein level of cytochrome P450 (CYP) 4A, which can convert ARA to 20-HETE. Reduced brain ARA metabolism in adult mice transiently exposed to postnatal fluoxetine, and a 74% reduction in CYP4A protein, suggest long-term effects independent of drug presence in brain ARA metabolism, and in CYP4A metabolites. These changes might contribute to reported altered behavior following early SSRI in rodents. Published by Elsevier Ltd.

156. ARAIII Reactor building (ARA608) Electrical and control details of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

156. ARA-III Reactor building (ARA-608) Electrical and control details of mobile work bridge over reactor and pipiing pits. Aerojet-general 880-area/GCRE-608-E-6. Date: November 1958. Ineel index code no. 063-0608-10-013-102621. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

132. ARAII Administration building (ARA613) elevations of north, south, east, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

132. ARA-II Administration building (ARA-613) elevations of north, south, east, and west sides. F. C. Torkelson Company 842-area/SL-1-613-A-2. Date: October 1959. Ineel index no. 070-0613-00-851-150054. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

119. ARAI Shop and maintenance (ARA627) building sections and details ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

119. ARA-I Shop and maintenance (ARA-627) building sections and details of interior mesh partitions. Norman Engineering Company 961-area/SF-627-A-3. Date: January 1959. Ineel index code no. 068-0627-00-613-102761. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

117. ARAI Shop and maintenance (ARA627) building roof and floor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

117. ARA-I Shop and maintenance (ARA-627) building roof and floor plan. Includes room finish and equipment schedule. Norman Engineering Company 961-area/SF-627-A-1. Date: January 1959. Ineel index code no. 068-0627-00-613-102759. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

112. ARAI Hot cell (ARA626) Building roof plan and details ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

112. ARA-I Hot cell (ARA-626) Building roof plan and details of roof ventilating equipment and parapet. Norman Engineering Company: 961-area/SF-626-A-2. Date: January 1959. Ineel index code no. 068-0626-00-613-102722. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Removing Peanut Allergen Ara h 1 from Peanut Extracts Using p-Aminobenzamidine

USDA-ARS?s Scientific Manuscript database

Rationale: Ara h 1 is one of 3 major allergens in peanut. Removing Ara h 1 from a peanut extract may produce a hypoallergenic peanut extract for immunotherapy and other purposes. Methods: Peanut extracts were treated overnight with and without 10 mM p-aminobenzamidine (pABA, a protease inhibitor) i...

90. ARAIII. GCRE reactor building (ARA608) mechanical loop pit. Shows ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

90. ARA-III. GCRE reactor building (ARA-608) mechanical loop pit. Shows nitrogen gas compressor in foreground, piping installations on walls of pit, and other details. February 24, 1959. Ineel photo no. 59-880. Photographer: Ken Mansfield. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Breeding versus bioengineering of hypoallergenic peanuts

USDA-ARS?s Scientific Manuscript database

Major allergen proteins in the peanut seed are storage proteins Ara h1, Ara h2, and Ara h3. While these proteins serve a vital function of nutrient reservoir activity in the peanut seed, it may be possible to eliminate some or to alter others to mitigate peanut allergic responses, but with little c...

147. ARAIII Control building (ARA607) Detail of instrument rack and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

147. ARA-III Control building (ARA-607) Detail of instrument rack and control console in control room. Aerojet-general 880-area/GCRE-607-E-4. Date: November 1958. Ineel index code no. 063-0607-10-013-102560. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

155. ARAIII Reactor building (ARA608) Details of reactor pit showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

155. ARA-III Reactor building (ARA-608) Details of reactor pit showing tray supports and fuel element storage rack. Aerojet-general 880-area/GCRE-608-MS-2. Date: November 1958. Ineel index code no. 063-0608-40-013-102625. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

160. ARAIII Service building (ARA610). Includes floor plan, north and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

160. ARA-III Service building (ARA-610). Includes floor plan, north and west elevations, and section details. Aerojet-general 880-area/GCRE-610-A-1. Date: February 1958. Ineel index code no. 063-0610-00-013-102684. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Development of Yoghurt with Juçara Pulp (Euterpe edulis M.) and the Probiotic Lactobacillus acidophilus La5.

PubMed

Geraldi, Marina V; Tulini, Fabricio L; Souza, Vanessa M; De Martinis, Elaine C P

2018-03-01

Yoghurts are dairy products consumed worldwide and can be supplemented with substances that provide extra health benefits as well as probiotic strains. In this context, the present study aimed to prepare a yoghurt added of juçara (Euterpe edulis M.) pulp and the commercial probiotic strain Lactobacillus acidophilus La5. Moreover, the probiotic survival during storage and after in vitro exposure to simulated gastric and enteric conditions was evaluated. Four formulations of yoghurt were prepared: (a) natural yoghurt, (b) yoghurt added of probiotic, (c) yoghurt added of juçara pulp, and (d) yoghurt added of probiotic culture and juçara pulp. The preparations were evaluated for survival of probiotic strain during storage and its tolerance to gastric and enteric conditions in vitro. The probiotic population in yoghurt remained unchanged during 28 days of storage. In addition, juçara pulp increased the probiotic resistance to simulated gastric and enteric conditions in the first day of storage. These data indicate that juçara pulp is a potential ingredient for the production of probiotic yoghurts.

IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study.

PubMed

Ballmer-Weber, B K; Lidholm, J; Fernández-Rivas, M; Seneviratne, S; Hanschmann, K M; Vogel, L; Bures, P; Fritsche, P; Summers, C; Knulst, A C; Le, T M; Reig, I; Papadopoulos, N G; Sinaniotis, A; Belohlavkova, S; Popov, T; Kralimarkova, T; de Blay, F; Purohit, A; Clausen, M; Jedrzejczak-Czechowcz, M; Kowalski, M L; Asero, R; Dubakiene, R; Barreales, L; Clare Mills, E N; van Ree, R; Vieths, S

2015-04-01

We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut-allergic population characterized under a common protocol. Sixty-eight peanut-allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge in all but anaphylactic subjects. Information of early or late (before or after 14 years of age) onset of peanut allergy was obtained from standardized questionnaires. IgE to peanut allergens rAra h 1-3, 6, 8-9, profilin and CCD was determined using ImmunoCAP. Seventy-eight percent of peanut allergics were sensitized to peanut extract and 90% to at least one peanut component. rAra h 2 was the sole major allergen for the peanut-allergic population. Geographical differences were observed for rAra h 8 and rAra h 9, which were major allergens for central/western and southern Europeans, respectively. Sensitization to rAra h 1 and 2 was exclusively observed in early-onset peanut allergy. Peanut-tolerant subjects were frequently sensitized to rAra h 8 or 9 but not to storage proteins. Sensitization to Ara h 2 ≥ 1.0 kUA /l conferred a 97% probability for a systemic reaction (P = 0.0002). Logistic regression revealed a significant influence of peanut extract sensitization and region on the occurrence of systemic reactions (P = 0.0185 and P = 0.0436, respectively). Sensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 ≥ 1.0 kUA /l is significantly associated with the development of systemic reactions to peanut. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The impact of renal artery stenosis on outcomes after open-heart surgery.

PubMed

Philip, Femi; Gornik, Heather L; Rajeswaran, Jeevanantham; Blackstone, Eugene H; Shishehbor, Mehdi H

2014-02-04

The aim of this study was to assess the impact of atherosclerotic renal artery stenosis (ARAS) on outcomes after open-heart surgery (OHS). Acute kidney injury after OHS portends significant morbidity and mortality. Data from all adult patients undergoing OHS from January 2000 to April 2010 who underwent renal duplex ultrasound were prospectively collected. ARAS was severe (60% to 99% stenosis) if peak systolic velocity was >200 cm/s. The associations between ARAS and post-operative reduction in glomerular filtration rate (GFR), need for renal replacement therapy, length of stay, and overall short-term and long-term mortality (up to 8 years) were tested using multivariate time-to-event adjusted analysis. A total of 714 patients were evaluated, with a mean age of 67 ± 12 years (63% men) and a mean GFR of 52 ± 25.9 ml/min/1.73 m(2). A total of 206 (29%) had ARAS; of these, 79% (n = 163) had unilateral and 21% (n = 43) had bilateral ARAS. ARAS was associated with peripheral artery disease (p = 0.004) and lower high-density lipoprotein levels (p = 0.04). Patients with advanced age (p = 0.01) and descending aorta grafting (p = 0.004) had significant post-operative reductions in GFR. Adjusted models showed a nonsignificant trend between ARAS and reduction in GFR (p = 0.09). ARAS was not associated with need for renal replacement therapy (p = 0.4), longer length of stay (p = 0.7), or mortality (p = 0.7), but low pre-operative GFR was a strong predictor of long-term mortality. ARAS does not appear to be associated with post-operative change in GFR, need for hemodialysis, longer length of stay, or mortality in patients undergoing OHS. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

VLA radio upper limit on Type IIn Supernova 2008S

NASA Astrophysics Data System (ADS)

Chandra, Poonam; Soderberg, Alicia

2008-02-01

Poonam Chandra and Alicia Soderberg report on behalf of a larger collaboration: We observed type IIn supernova SN 2008S (CBET 1234) with the Very Large Array (VLA) on 2008, February 10.62 UT. We do not detect any radio emission at the supernova position (CBET 1234). The flux density at the supernova position is -62 +/- 36 uJy.

Antenna data storage concept for phased array radio astronomical instruments

NASA Astrophysics Data System (ADS)

Gunst, André W.; Kruithof, Gert H.

2018-04-01

Low frequency Radio Astronomy instruments like LOFAR and SKA-LOW use arrays of dipole antennas for the collection of radio signals from the sky. Due to the large number of antennas involved, the total data rate produced by all the antennas is enormous. Storage of the antenna data is both economically and technologically infeasible using the current state of the art storage technology. Therefore, real-time processing of the antenna voltage data using beam forming and correlation is applied to achieve a data reduction throughout the signal chain. However, most science could equally well be performed using an archive of raw antenna voltage data coming straight from the A/D converters instead of capturing and processing the antenna data in real time over and over again. Trends on storage and computing technology make such an approach feasible on a time scale of approximately 10 years. The benefits of such a system approach are more science output and a higher flexibility with respect to the science operations. In this paper we present a radically new system concept for a radio telescope based on storage of raw antenna data. LOFAR is used as an example for such a future instrument.

Microsat and Lunar-Based Imaging of Radio Bursts

NASA Technical Reports Server (NTRS)

MacDowall, R. J.; Gopalswamy, N.; Kaiser, M. L.; Demaio, L. D.; Bale, S. D.; Kasper, J. C.; Lazarus, A. J.; Howard, R. E.; Jones, D. L.; Reiner, M. J.;

Jansky Array mapping of Gravitational Bursts as Afterglows in Radio (JAGWAR): The VLA Large Program and Initial Results

NASA Astrophysics Data System (ADS)

Mooley, Kunal; Hallinan, Gregg; Hotokezaka, Kenta; Frail, Dale; Myers, Steven T.; Horesh, Assaf; Kasliwal, Mansi; Kulkarni, Shri; Pound Singer, Leo; nissanke, Samaya; Rana, Javed

2018-01-01

The era of gravitational waves and multi-messenger astronomy has begun. Telescopes around the globe are now in hot pursuit of electromagnetic counterparts (EM) to aLIGO/VIRGO sources, especially double-neutron star (NS-NS) and neutron star-black hole mergers (NS-BH). The EM counterparts are crucial for 1) providing arcsecond localization and identifying the precise host galaxy and merger redshift, 2) understanding the energetics and physics of the merger, 3) mapping their environments and pre-merger mass ejection processes, and 4) confirming the validity of the GW signals at low signal-to-noise ratios. Radio wavelengths provide one of the best diagnostics of both the dynamical sub-relativistic ejecta and any ultra-relativistic jet launched, as well as the possible interaction of these two components. In this talk I will introduce the Jansky Array mapping of Gravitational Bursts as Afterglows in Radio (JAGWAR) program, running on the VLA, aimed at maximizing the discoveries of the radio afterglows of NS-NS and NS-BH mergers. I will also present the JAGWAR results from the aLIGO/VIRGO observing run O2, which concluded in August 2017.

A Digital Backend for the Low Frequency All Sky Monitor

NASA Astrophysics Data System (ADS)

Dartez, L. P.

2014-04-01

The Low Frequency All Sky Monitor (LoFASM) is a distributed array of dipole antennas that are sensitive to radio frequencies from 10 to 88 MHz. The primary science goals of LoFASM are the detection and study of low-frequency radio transients, a high priority science goal as deemed by the National Research Council's decadal survey. LoFASM consists of antennas and front-end electronics that were originally developed for the Long Wavelength Array (LWA) by the U.S. Naval Research Lab, the University of New Mexico, Virginia Tech, and the Jet Propulsion Laboratory. LoFASM, funded by the U.S. Department of Defense, will initially consist of four stations, each consisting of 12 dual-polarization dipole antennas. In a single station, RF signals from each of the individual LoFASM dipoles are combined in phase in order to synthesize LoFASM's beam. The LoFASM RF signals are phased up so that the resulting beam is sensitive to radio emission that originates from the zenith and RF signals approaching from the horizon are attenuated. Digitally, this is achieved using a full Stokes 100MHz correlating spectrometer constructed using field programmable gate array (FPGA) technology. In this thesis I will describe the design and usage of the LoFASM Correlator.

The Early Development of Indian Radio Astronomy: A Personal Perspective

NASA Astrophysics Data System (ADS)

Swarup, Govind

In this chapter I recall my initiation into the field of radio astronomy during 1953-1955 at CSIRO, Australia; the transfer of thirty-two 6-feet (1.8-m) diameter parabolic dishes from Potts Hill, Sydney, to India in 1958; and their erection at Kalyan, near Bombay (Mumbai), in 1963-1965. The Kalyan Radio Telescope was the first modern radio telescope built in India. This led to the establishment of a very active radio astronomy group at the Tata Institute of Fundamental Research, which subsequently built two world-class radio telescopes during the last 50 years and also contributed to the development of an indigenous microwave antenna industry in India. The Ooty Radio Telescope, built during 1965-1970, has an ingenious design which takes advantage of India's location near the Earth's Equator. The long axis of this 530-m × 30-m parabolic cylinder was made parallel to the Equator, by placing it on a hill with the same slope as the geographic latitude ( 11°), thus allowing it to track celestial sources continuously for 9.5 h every day. By utilizing lunar occultations, the telescope was able to measure the angular sizes of a large number of faint radio galaxies and quasars with arc-second resolution for the first time. Subsequently, during the 1990s, the group set up the Giant Metrewave Radio Telescope (GMRT) near Pune in western India, in order to investigate certain astrophysical phenomena which are best studied at decimetre and metre wavelengths. The GMRT is an array of 30 fully steerable 45-m diameter parabolic dishes, which operates at several frequencies below 1.43 GHz. These efforts have also contributed to the international proposal to construct the Square Kilometre Array (SKA). This chapter is a revised version of Swarup (Journal of Astronomical History and Heritage, 9: 21-33, 2006).

Magnetic resonance elastography can monitor changes in medullary stiffness in response to treatment in the swine ischemic kidney

PubMed Central

Zhang, Xin; Zhu, Xiangyang; Ferguson, Christopher M.; Jiang, Kai; Burningham, Tyson; Lerman, Amir; Lerman, Lilach O.

2018-01-01

Object Low-energy shockwave (SW) therapy attenuates damage in the stenotic kidney (STK) caused by atherosclerotic renal artery stenosis (ARAS). We hypothesized that magnetic resonance elastography (MRE) would detect attenuation of fibrosis following SW in unilateral ARAS kidneys. Materials and Methods Domestic pigs were randomized to control, unilateral ARAS, and ARAS treated with 6 sessions of SW over 3 consecutive weeks (n=7 each) starting after 3 weeks of ARAS or sham. Four weeks after SW treatment, renal fibrosis was evaluated with MRE in-vivo or trichrome staining ex-vivo. Blood pressure, single-kidney renal-blood-flow (RBF) and glomerular-filtration-rate (GFR) were assessed. Results MRE detected increased stiffness in the STK medulla (15.3±2.1 vs. 10.1±0.8 kPa, p<0.05) that moderately correlated with severity of fibrosis (R2=0.501, p<0.01), but did not identify mild STK cortical or contralateral kidney fibrosis. Trichrome staining showed that medullary fibrosis was increased in ARAS and alleviated by SW (10.4±1.8% vs. 2.9±0.2%, p<0.01). SW slightly decreased blood pressure and normalized STK RBF and GFR in ARAS. In the contralateral kidney, SW reversed the increase in RBF and GFR. Conclusion MRE might be a tool for noninvasive monitoring of medullary fibrosis in response to treatment in kidney disease. PMID:29289980

Radio Observations of Type Ia SN2006X

NASA Astrophysics Data System (ADS)

Soderberg, Alicia

2006-02-01

Alicia Soderberg (Caltech) reports: I observed the Type Ia supernova 2006X in NGC 4321 (IAUC 8667, CBET 393) with the Very Large Array on 2006 February 9.34 UT (approximately 2 days after optical discovery). The 2.5 hour observation at 8.46 GHz reveals no radio source coincident with the optical SN position. I place a limit on the radio flux density of 45 microJy (3 sigma). At a distance of 16 Mpc this limit corresponds to a luminosity of 1.4 x 10^25 erg/s/Hz.

A Sentry on the Universe

NASA Astrophysics Data System (ADS)

Dixon, Robert

This chapter introduces the Argus radio telescope concept, a radically new approach to radio telescope design (not to be confused with The SETI League's Project Argus, a linked global array of fairly conventional radio telescopes). It represents a complete departure from designs that have been used ever since the invention of the first telescope by Galileo in 1609. It starts over from the beginning, and in doing so overcomes the legacy of Galileo. Argus can do things that are amazing and even hard to believe, when viewed in the context of previous telescopes. Here are some examples.

Baseline-dependent averaging in radio interferometry

NASA Astrophysics Data System (ADS)

Wijnholds, S. J.; Willis, A. G.; Salvini, S.

2018-05-01

This paper presents a detailed analysis of the applicability and benefits of baseline-dependent averaging (BDA) in modern radio interferometers and in particular the Square Kilometre Array. We demonstrate that BDA does not affect the information content of the data other than a well-defined decorrelation loss for which closed form expressions are readily available. We verify these theoretical findings using simulations. We therefore conclude that BDA can be used reliably in modern radio interferometry allowing a reduction of visibility data volume (and hence processing costs for handling visibility data) by more than 80 per cent.

VLA observations of radio sources in interacting galaxy pairs in poor clusters

NASA Technical Reports Server (NTRS)

Batuski, David J.; Hanisch, Robert J.; Burns, Jack O.

1992-01-01

Observations of 16 radio sources in interacting galaxies in 14 poor clusters were made using the Very Large Array in the B configuration at lambda of 6 and 2 cm. These sources had been unresolved in earlier observations at lambda of 21 cm, and were chosen as a sample to determine which of three models for radio source formation actually pertains in interacting galaxies. From the analysis of this sample, the starburst model appears most successful, but the 'central monster' model could pertain in some cases.

The first VLBI image of an infrared-faint radio source

NASA Astrophysics Data System (ADS)

Middelberg, E.; Norris, R. P.; Tingay, S.; Mao, M. Y.; Phillips, C. J.; Hotan, A. W.

2008-11-01

Context: We investigate the joint evolution of active galactic nuclei and star formation in the Universe. Aims: In the 1.4 GHz survey with the Australia Telescope Compact Array of the Chandra Deep Field South and the European Large Area ISO Survey - S1 we have identified a class of objects which are strong in the radio but have no detectable infrared and optical counterparts. This class has been called Infrared-Faint Radio Sources, or IFRS. 53 sources out of 2002 have been classified as IFRS. It is not known what these objects are. Methods: To address the many possible explanations as to what the nature of these objects is we have observed four sources with the Australian Long Baseline Array. Results: We have detected and imaged one of the four sources observed. Assuming that the source is at a high redshift, we find its properties in agreement with properties of Compact Steep Spectrum sources. However, due to the lack of optical and infrared data the constraints are not particularly strong.

Interferometry meets the third and fourth dimensions in galaxies

NASA Astrophysics Data System (ADS)

Trimble, Virginia

2015-02-01

Radio astronomy began with one array (Jansky's) and one paraboloid of revolution (Reber's) as collecting areas and has now reached the point where a large number of facilities are arrays of paraboloids, each of which would have looked enormous to Reber in 1932. In the process, interferometry has contributed to the counting of radio sources, establishing superluminal velocities in AGN jets, mapping of sources from the bipolar cow shape on up to full grey-scale and colored images, determining spectral energy distributions requiring non-thermal emission processes, and much else. The process has not been free of competition and controversy, at least partly because it is just a little difficult to understand how earth-rotation, aperture-synthesis interferometry works. Some very important results, for instance the mapping of HI in the Milky Way to reveal spiral arms, warping, and flaring, actually came from single moderate-sized paraboloids. The entry of China into the radio astronomy community has given large (40-110 meter) paraboloids a new lease on life.

A high performance cost-effective digital complex correlator for an X-band polarimetry survey.

PubMed

Bergano, Miguel; Rocha, Armando; Cupido, Luís; Barbosa, Domingos; Villela, Thyrso; Boas, José Vilas; Rocha, Graça; Smoot, George F

2016-01-01

The detailed knowledge of the Milky Way radio emission is important to characterize galactic foregrounds masking extragalactic and cosmological signals. The update of the global sky models describing radio emissions over a very large spectral band requires high sensitivity experiments capable of observing large sky areas with long integration times. Here, we present the design of a new 10 GHz (X-band) polarimeter digital back-end to map the polarization components of the galactic synchrotron radiation field of the Northern Hemisphere sky. The design follows the digital processing trends in radio astronomy and implements a large bandwidth (1 GHz) digital complex cross-correlator to extract the Stokes parameters of the incoming synchrotron radiation field. The hardware constraints cover the implemented VLSI hardware description language code and the preliminary results. The implementation is based on the simultaneous digitized acquisition of the Cartesian components of the two linear receiver polarization channels. The design strategy involves a double data rate acquisition of the ADC interleaved parallel bus, and field programmable gate array device programming at the register transfer mode. The digital core of the back-end is capable of processing 32 Gbps and is built around an Altera field programmable gate array clocked at 250 MHz, 1 GSps analog to digital converters and a clock generator. The control of the field programmable gate array internal signal delays and a convenient use of its phase locked loops provide the timing requirements to achieve the target bandwidths and sensitivity. This solution is convenient for radio astronomy experiments requiring large bandwidth, high functionality, high volume availability and low cost. Of particular interest, this correlator was developed for the Galactic Emission Mapping project and is suitable for large sky area polarization continuum surveys. The solutions may also be adapted to be used at signal processing subsystem levels for large projects like the square kilometer array testbeds.

Exploring the Last Electromagnetic Frontier with the Long Wavelength Array (LWA)

NASA Astrophysics Data System (ADS)

Kassim, Namir E.; Cohen, A. S.; Crane, P. C.; Gross, C. A.; Hicks, B. C.; Lane, W. M.; Lazio, J.; Polisensky, E. J.; Ray, P. S.; Weiler, K. W.; Clarke, T. E.; Schmitt, H. R.; Hartman, J. M.; Helmboldt, J. F.; Craig, J.; Gerstle, W.; Pihlstrom, Y.; Rickard, L. J.; Taylor, G. B.; Ellingson, S. W.; D'Addario, L. R.; Navarro, R.

2009-05-01

Several decades ago, instruments like the Very Large Array (VLA) first opened the GHz frequency sky to high dynamic range imaging. Today, a path-finding VLA 74 MHz system is providing the first sub-arcminute resolution view of the radio universe below 100 MHz, a technical innovation inspiring an emerging suite of large (> 100 km), much more powerful long-wavelength instruments including the Long Wavelength Array (LWA). Similar in philosophy to the VLA and also located in New Mexico, the LWA will be a versatile, user-oriented electronic array designed to open the 20--80 MHz frequency range to detailed exploration for the first time. The LWA's mJy sensitivity and near-arcsecond resolution will surpass, by 2--3 orders of magnitude, the imaging power of previous interferometers in its frequency range. LWA scientific frontiers include: (1) the high-z universe, including distant radio galaxies and clusters - tools for understanding the earliest black holes and the cosmological evolution of Dark Matter and Dark Energy, respectively; (2) acceleration, propagation, and turbulence in the ISM, including the space-distribution and spectrum of Galactic cosmic rays and supernova remnants; (3) planetary, solar, and space science, including space-weather prediction and extra-solar planet searches; and (4) the radio transient universe including GRBs, ultra-high energy cosmic rays, and new sources of unknown origin. Because the LWA will explore one of the most poorly investigated spectral regions the potential for new discoveries is high, and there is a strong synergy with exciting new X-ray and Gamma-ray measurements. The LWA will also provide an unparalleled measure of small-scale ionospheric structure, a pre-requisite for accurate calibration and imaging. This presentation focuses on LWA science, while a companion paper reviews the technical design subjected to Preliminary Design Review in March 2009. Basic research in radio astronomy at the Naval Research Laboratory is supported by 6.1 base funding.

Reduction of IgE binding and nonpromotion of Aspergillus flavus fungal growth by simultaneously silencing Ara h 2 and Ara h 6 in peanut.

USDA-ARS?s Scientific Manuscript database

The most potent peanut allergens, Ara h 2 and 6, were silenced in transgenic plants by RNA interference. Three independent transgenic lines were recovered after microprojectile bombardment, of which two contained single, integrated copies of the transgene. The third line contained multiple copies ...

114. ARAI Hot cell (ARA626) Building details of fuel storage ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

114. ARA-I Hot cell (ARA-626) Building details of fuel storage pit in plan and section. Spaces shown for 20 elements. Norman Engineering Company: 961-area/SF-626-S-4. Date: January 1959. Ineel index code no. 068-0626-60-613-102752. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

72. ARAII. Interior view in ARA602 support building showing oilfired ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. ARA-II. Interior view in ARA-602 support building showing oil-fired hot air furnace and hot water boiler in foreground; hot water tank and diesel generator in background. December 12, 1957. Ineel photo no. 57-6099. Photographer: Jack L. Anderson. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Structure, Function and Epitope Mapping the Peanut Panallergen Ara h 8

USDA-ARS?s Scientific Manuscript database

The incidence of peanut allergy continues to rise in the US and Europe. Whereas exposure to the major allergens Ara h 1, 2, 3, and 6 can cause fatal anaphylaxis, exposure to the minor allergens usually does not. Ara h 8 is a minor allergen. Importantly, it is the minor food allergens that are though...

Structure and function of the peanut panallergen Ara h 8

USDA-ARS?s Scientific Manuscript database

The incidence of peanut allergy continues to rise in the US and Europe; whereas, exposure to the major allergens Ara h 1, 2, 3, and 6 can cause fatal anaphylaxis, exposure to the minor allergens usually does not. Ara h 8 is a minor allergen. Importantly, it is the minor food allergens that are tho...

86. ARAIII. GCRE reactor building (ARA608) showing mechanical loop pit ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. ARA-III. GCRE reactor building (ARA-608) showing mechanical loop pit after building shell had been erected. Beyond pit are demineralized water surge tank and heat exchanger. Camera facing northeast. December 22, 1958. Ineel photo no. 58-6427. Photographer: Ken Mansfield. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

129. ARAII Administrative and technical support building (ARA606) sections showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

129. ARA-II Administrative and technical support building (ARA-606) sections showing roof and wall details and longitudinal section. C.A. Sundberg and Associates 866-area/ALPR-606-A-5. Date: May 1958. Ineel index code no. 070-0606-00-822-102828. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

121. ARAI Guard house (ARA628). Drawing shows north, south, east, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

121. ARA-I Guard house (ARA-628). Drawing shows north, south, east, and west elevations, floor plan, counter details, and roof plan. Norman Engineering Corporation 961-area/SF-628-A-1. Date: January 1959. Ineel index code no. 063-0628-00-613-102772. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

145. ARAIII Control building (ARA607) Sections. Shows highbay section of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

145. ARA-III Control building (ARA-607) Sections. Shows high-bay section of building over crane rail and beam. Indicates materials of exterior siding. Aerojet-general 880-area/GCRE-607-A-11. Date: February 1958. Ineel index code no. 063-0607-00-013-102556. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

128. ARAII Administrative and technical support building (ARA606) elevations for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

128. ARA-II Administrative and technical support building (ARA-606) elevations for northwest, southwest, northeast, and southeast sides. C.A. Sundberg and Associates 866-area/ALPR-606-A-3. Date: May 1958. Ineel index code no. 070-0606-00-822-102826. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

150. ARAIII Reactor building (ARA608) Sections. Show highbay section, heater ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

150. ARA-III Reactor building (ARA-608) Sections. Show high-bay section, heater stack, and depth of reactor, piping, and heater pits. Aerojet-general 880-area/GCRE-608-A-3. Date: February 1958. Ineel index code no. 063-0608-00-013-102613. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

79. ARAIII. Early construction view of GCRE reactor building (ARA608) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. ARA-III. Early construction view of GCRE reactor building (ARA-608) showing deep excavation, reinforcing steel, and forms for concrete placement for reactor and other pits. Camera facing southeast. July 22, 1958. Ineel photo no. 58-3466. Photographer: Ken Mansfield. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

PRIFIRA: General regularization using prior-conditioning for fast radio interferometric imaging†

NASA Astrophysics Data System (ADS)

Naghibzadeh, Shahrzad; van der Veen, Alle-Jan

2018-06-01

Image formation in radio astronomy is a large-scale inverse problem that is inherently ill-posed. We present a general algorithmic framework based on a Bayesian-inspired regularized maximum likelihood formulation of the radio astronomical imaging problem with a focus on diffuse emission recovery from limited noisy correlation data. The algorithm is dubbed PRIor-conditioned Fast Iterative Radio Astronomy (PRIFIRA) and is based on a direct embodiment of the regularization operator into the system by right preconditioning. The resulting system is then solved using an iterative method based on projections onto Krylov subspaces. We motivate the use of a beamformed image (which includes the classical "dirty image") as an efficient prior-conditioner. Iterative reweighting schemes generalize the algorithmic framework and can account for different regularization operators that encourage sparsity of the solution. The performance of the proposed method is evaluated based on simulated one- and two-dimensional array arrangements as well as actual data from the core stations of the Low Frequency Array radio telescope antenna configuration, and compared to state-of-the-art imaging techniques. We show the generality of the proposed method in terms of regularization schemes while maintaining a competitive reconstruction quality with the current reconstruction techniques. Furthermore, we show that exploiting Krylov subspace methods together with the proper noise-based stopping criteria results in a great improvement in imaging efficiency.

High resolution radio imaging study of the Pulsar Wind Nebula MSH 15-52

NASA Astrophysics Data System (ADS)

Leung, W.-Y.; Ng, C.-Y.

2016-06-01

We present a new high-resolution radio imaging study of the pulsar wind nebula (PWN) MSH 15-52, also dubbed as "the hand of God", with the Australia Telescope Compact Array observations. The system is powered by a young and energetic radio pulsar B1509-58 with high spin down luminosity of E(dot) = 2 x 10^37 erg/s. Previous X-ray images have shown that the PWN has a complex hand-shape morphology extending over 10 pc with features like jets, arc, filaments and enhanced emission knots in the HII region RCW 89. The new 6cm and 3cm radio images show different morphology than the X-ray counterpart. No radio counterpart of the X-ray jet is detected, instead we found enhanced emission in a sheath surrounding the jet. Additional small-scale features including a polarized linear filament next to the pulsar have also been discovered. Our polarisation measurements show that the intrinsic orientation of magnetic field aligns with the sheath. Finally, spectral analysis results indicate a steep spectrum for the system, which is rather unusual among PWNe. Implications of these findings will be discussed. The Australia Telescope Compact Array is part of the Australia Telescope National Facility which is funded by the Commonwealth of Australia for operation as a National Facility managed by CSIRO. This work is supported by an ECS grant under HKU 709713P.

Phosphate limitation promotes unsaturated fatty acids and arachidonic acid biosynthesis by microalgae Porphyridium purpureum.

PubMed

Su, Gaomin; Jiao, Kailin; Li, Zheng; Guo, Xiaoyi; Chang, Jingyu; Ndikubwimana, Theoneste; Sun, Yong; Zeng, Xianhai; Lu, Yinghua; Lin, Lu

2016-07-01

Polyunsaturated fatty acids (PUFAs) are highly appreciated on their nutritive value for human health and aquaculture. P. purpureum, one of the red microalgae acknowledged as a promising accumulator of ARA, was chosen as the target algae in the present research. Effects of sodium bicarbonate (0.04-1.2 g/L), temperature (25, 30 and 33 °C) and phosphate (0.00-0.14 g/L) on biomass yield, total fatty acids (TFA) and arachidonic acid (ARA) accumulation were investigated systemically. NaHCO3 dose of 0.8 g/L and moderate temperature of 30 °C were preferred. In addition, TFA and ARA production were significantly enhanced by an appropriate concentration of phosphate, and the highest TFA yield of 666.38 mg/L and ARA yield of 159.74 mg/L were obtained at a phosphate concentration of 0.035 g/L. Interestingly, with phosphate concentration continuing to fall, UFA/TFA and ARA/EPA ratios were increased accordingly, suggesting that phosphate limitation promoted unsaturated fatty acids and arachidonic acid biosynthesis. Low concentration of phosphate may be favored to increase the enzymatic activities of ∆6-desaturase, which played a key role in catalyzing the conversion of C16:0 to C18:2, and thus the selectivity of UFA increased. Meanwhile, the increase of ARA selectivity could be attributed to ω6 pathway promotion and ∆17-desaturase activity inhibition with phosphate limitation. Phosphate limitation strategy enhanced unsaturated fatty acids and ARA biosynthesis in P. purpureum, and can be applied in commercial scale manufacturing and commercialization of ARA.

Demographic Risk Factors for Alcohol-Related Aggression In and Around Licensed Venues.

PubMed

Zinkiewicz, Lucy; Curtis, Ashlee; Meurer, Hannah; Miller, Peter

2016-03-01

Few studies have examined the role of gender and both area-level and individual socio-economic status (SES) as independent predictors of alcohol-related aggression (ARA) in and around licensed venues. The aim of the present study was to investigate the relationship between gender, area-level SES and individual SES (operationalised as occupational category) and ARA in and around licensed venues. The sample comprised 697 men and 649 women aged 16-47, who completed a patron intercept survey as part of a larger study assessing trends in harm and stakeholders' views surrounding local community level interventions in dealing with alcohol-related problems in the night-time economy. Binary logistic regression analyses showed that age, gender, occupational category, area-level SES and level of intoxication at time of interview were all significant predictors of involvement in ARA. Being male doubled the odds of involvement in ARA, while age was a protective factor. Blue collar workers had more than double the odds of ARA involvement of professionals, while those living in the most socio-economically disadvantaged areas were over twice as likely to report experiencing ARA compared to those living in the most advantaged areas. However, assessment of the predictive model by gender revealed that effects of age, occupational category and area-level SES were restricted to male participants, with greater intoxication no longer predictive. ARA among patrons was significantly more likely to occur among men, those in blue collar occupations, and individuals living in low SES areas, suggesting both individual and area-level disadvantage may play a role in ARA. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.

Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.

PubMed

Palmeira dos Santos, Caroline; Pereira, Gustavo J S; Barbosa, Christiano M V; Jurkiewicz, Aron; Smaili, Soraya S; Bincoletto, Claudia

2014-06-01

As the molecular mechanisms of Cytarabine,one of the most important drugs used in the leukaemia’s treatment, are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) as autophagy inhibitors, we aim to evaluate the contribution of an autophagic mechanism to Cytarabine (AraC)-induced death of HL60 leukaemia cells. Trypan blue exclusion and AnnexinV/PI assays were used to evaluate HL60 cell death under AraC treatment in the presence or absence of 3MA and CQ. Western blotting and immunofluorescence experiments were performed to show the involvement of apoptosis and autophagy protein expressions. Phenotypic characterization of HL60-treated cells was performed by using immunophenotyping. Clonogenic assays were applied to analyse clonal function of HL60-treated cells. We observed that although autophagy inhibition by 3MA, but not CQ, increased the death of HL60 AraC cells after 24 h of treatment, no significant differences between AraC and AraC + 3MA-treated groups were observed by using clonogenic assay. In addition, increased number of immature (CD34(+)/CD38(−)Lin(−/low)) HL60 cells was found in AraC and AraC-3MA groups when compared with control untreated cells. Although AraC anti-leukaemia effects could be potentiated by 3MA autophagy inhibition after 24 h of exposure, leukaemia cell resistance, the main causes of treatment failure, is also promoted by autophagy initial stage impairment by 3MA, denoting the complex role of autophagy in leukaemia cells’ response to chemotherapy.

Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function.

PubMed

Zhuo, Ming; Gorgun, Murat F; Englander, Ella W

2018-06-01

Peripheral Nervous System (PNS) neurotoxicity caused by cancer drugs hinders attainment of chemotherapy goals. Due to leakiness of the blood nerve barrier, circulating chemotherapeutic drugs reach PNS neurons and adversely affect their function. Chemotherapeutic drugs are designed to target dividing cancer cells and mechanisms underlying their toxicity in postmitotic neurons remain to be fully clarified. The objective of this work was to elucidate progression of events triggered by antimitotic drugs in postmitotic neurons. For proof of mechanism study, we chose cytarabine (ara-C), an antimetabolite used in treatment of hematological cancers. Ara-C is a cytosine analog that terminates DNA synthesis. To investigate how ara-C affects postmitotic neurons, which replicate mitochondrial but not genomic DNA, we adapted a model of Dorsal Root Ganglion (DRG) neurons. We showed that DNA polymerase γ, which is responsible for mtDNA synthesis, is inhibited by ara-C and that sublethal ara-C exposure of DRG neurons leads to reduction in mtDNA content, ROS generation, oxidative mtDNA damage formation, compromised mitochondrial respiration and diminution of NADPH and GSH stores, as well as, activation of the DNA damage response. Hence, it is plausible that in ara-C exposed DRG neurons, ROS amplified by the high mitochondrial content shifts from physiologic to pathologic levels signaling stress to the nucleus. Combined, the findings suggest that ara-C neurotoxicity in DRG neurons originates in mitochondria and that continuous mtDNA synthesis and reliance on oxidative phosphorylation for energy needs sensitize the highly metabolic neurons to injury by mtDNA synthesis terminating cancer drugs. Copyright © 2018 Elsevier Inc. All rights reserved.

Radio haloes in nearby galaxies modelled with 1D cosmic ray transport using SPINNAKER

NASA Astrophysics Data System (ADS)

Heesen, V.; Krause, M.; Beck, R.; Adebahr, B.; Bomans, D. J.; Carretti, E.; Dumke, M.; Heald, G.; Irwin, J.; Koribalski, B. S.; Mulcahy, D. D.; Westmeier, T.; Dettmar, R.-J.

2018-05-01

We present radio continuum maps of 12 nearby (D ≤ 27 Mpc), edge-on (i ≥ 76°), late-type spiral galaxies mostly at 1.4 and 5 GHz, observed with the Australia Telescope Compact Array, Very Large Array, Westerbork Synthesis Radio Telescope, Effelsberg 100-m, and Parkes 64-m telescopes. All galaxies show clear evidence of radio haloes, including the first detection in the Magellanic-type galaxy NGC 55. In 11 galaxies, we find a thin and a thick disc that can be better fitted by exponential rather than Gaussian functions. We fit our SPINNAKER (SPectral INdex Numerical Analysis of K(c)osmic-ray Electron Radio-emission) 1D cosmic ray transport models to the vertical model profiles of the non-thermal intensity and to the non-thermal radio spectral index in the halo. We simultaneously fit for the advection speed (or diffusion coefficient) and magnetic field scale height. In the thick disc, the magnetic field scale heights range from 2 to 8 kpc with an average across the sample of 3.0 ± 1.7 kpc; they show no correlation with either star formation rate (SFR), SFR surface density (ΣSFR), or rotation speed (Vrot). The advection speeds range from 100 to 700 km s - 1 and display correlations of V∝SFR0.36 ± 0.06 and V∝ Σ _SFR^{0.39± 0.09}; they agree remarkably well with the escape velocities (0.5 ≤ V/Vesc ≤ 2), which can be explained by cosmic ray-driven winds. Radio haloes show the presence of disc winds in galaxies with ΣSFR > 10 - 3 M⊙ yr - 1 kpc - 2 that extend over several kpc and are driven by processes related to the distributed star formation in the disc.

Uplink Array Calibration via Far-Field Power Maximization

NASA Technical Reports Server (NTRS)

Vilnrotter, V.; Mukai, R.; Lee, D.

2006-01-01

Uplink antenna arrays have the potential to greatly increase the Deep Space Network s high-data-rate uplink capabilities as well as useful range, and to provide additional uplink signal power during critical spacecraft emergencies. While techniques for calibrating an array of receive antennas have been addressed previously, proven concepts for uplink array calibration have yet to be demonstrated. This article describes a method of utilizing the Moon as a natural far-field reflector for calibrating a phased array of uplink antennas. Using this calibration technique, the radio frequency carriers transmitted by each antenna of the array are optimally phased to ensure that the uplink power received by the spacecraft is maximized.

Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.

PubMed

Siitonen, Timo; Koistinen, Pirjo; Savolainen, Eeva-Riitta

2005-11-01

The effects of valproate and butyrate were investigated in an acute myeloblastic cell line (OCI/AML-2) on cytotoxicity, cell cycle profile and expression of cell cycle regulating proteins in the presence of cytarabine (Ara-C) and etoposide. As a single agent valproate and butyrate inhibited AML cell growth but did not significantly induce cell death. A dramatic increase in cytotoxicity was observed when combining valproate or butyrate with Ara-C, whereas, co-addition of them with etoposide had much smaller effect on cell death. Valproate induced a clear G1 phase arrest and up-regulated cyclin D1 expression in the presence of Ara-C and etoposide. In addition, valporate was able to block the Ara-C-induced down-regulation of p27(Kip1) expression but not that induced by etoposide.

From anatomy to function: diagnosis of atherosclerotic renal artery stenosis.

PubMed

Odudu, Aghogho; Vassallo, Diana; Kalra, Philip A

2015-12-01

Atherosclerotic renal artery stenosis (ARAS) affects 7% of the over 65 s and will be increasingly common with an ageing population. ARAS obstructs normal renal perfusion with adverse renal and cardiovascular consequences. Drug therapy is directed at reducing atherosclerotic risk. Two recent major trials of revascularization for ARAS showed that clinical outcomes were not improved beyond those offered by optimal drug therapy in most patients. This reflects experimental data showing that restoration of blood flow alone may not attenuate a cascade of tissue injury. A shift from anatomic to functional imaging of ARAS coupled to novel therapies might improve clinical outcomes in selected patients. This review outlines the case for separately assessing hemodynamic significance of arterial stenosis and functional reserve of renal parenchymal tissue. The authors consider current and emerging diagnostic techniques for ARAS and their potential to allow individualized and functionally directed treatments.

Development of Very Long Baseline Interferometry (VLBI) techniques in New Zealand: Array simulation, image synthesis and analysis

NASA Astrophysics Data System (ADS)

Weston, S. D.

2008-04-01

This thesis presents the design and development of a process to model Very Long Base Line Interferometry (VLBI) aperture synthesis antenna arrays. In line with the Auckland University of Technology (AUT) Institute for Radiophysics and Space Research (IRSR) aims to develop the knowledge, skills and experience within New Zealand, extensive use of existing radio astronomical software has been incorporated into the process namely AIPS (Astronomical Imaging Processing System), MIRIAD (a radio interferometry data reduction package) and DIFMAP (a program for synthesis imaging of visibility data from interferometer arrays of radio telescopes). This process has been used to model various antenna array configurations for two proposed New Zealand sites for antenna in a VLBI array configuration with existing Australian facilities and a passable antenna at Scott Base in Antarctica; and the results are presented in an attempt to demonstrate the improvement to be gained by joint trans-Tasman VLBI observation. It is hoped these results and process will assist the planning and placement of proposed New Zealand radio telescopes for cooperation with groups such as the Australian Long Baseline Array (LBA), others in the Pacific Rim and possibly globally; also potential future involvement of New Zealand with the SKA. The developed process has also been used to model a phased building schedule for the SKA in Australia and the addition of two antennas in New Zealand. This has been presented to the wider astronomical community via the Royal Astronomical Society of New Zealand Journal, and is summarized in this thesis with some additional material. A new measure of quality ("figure of merit") for comparing the original model image and final CLEAN images by utilizing normalized 2-D cross correlation is evaluated as an alternative to the existing subjective visual operator image comparison undertaken to date by other groups. This new unit of measure is then used ! in the presentation of the results to provide a quantative comparison of the different array configurations modelled. Included in the process is the development of a new antenna array visibility program which was based on a Perl code script written by Prof Steven Tingay to plot antenna visibilities for the Australian Square Kilometre Array (SKA) proposal. This has been expanded and improved removing the hard coded fixed assumptions for the SKA configuration, providing a new useful and flexible program for the wider astronomical community. A prototype user interface using html/cgi/perl was developed for the process so that the underlying software packages can be served over the web to a user via an internet browser. This was used to demonstrate how easy it is to provide a friendlier interface compared to the existing cumbersome and difficult command line driven interfaces (although the command line can be retained for more experienced users).

The Next-Generation Very Large Array: Technical Overview

NASA Astrophysics Data System (ADS)

McKinnon, Mark; Selina, Rob

2018-01-01

As part of its mandate as a national observatory, the NRAO is looking toward the long range future of radio astronomy and fostering the long term growth of the US astronomical community. NRAO has sponsored a series of science and technical community meetings to consider the science mission and design of a next-generation Very Large Array (ngVLA), building on the legacies of the Atacama Large Millimeter/submillimeter Array (ALMA) and the Very Large Array (VLA).The basic ngVLA design emerging from these discussions is an interferometric array with approximately ten times the sensitivity and ten times higher spatial resolution than the VLA and ALMA radio telescopes, optimized for operation in the wavelength range 0.3cm to 3cm. The ngVLA would open a new window on the Universe through ultra-sensitive imaging of thermal line and continuum emission down to milli-arcsecond resolution, as well as unprecedented broadband continuum polarimetric imaging of non-thermal processes. The specifications and concepts for major ngVLA system elements are rapidly converging.We will provide an overview of the current system design of the ngVLA. The concepts for major system elements such as the antenna, receiving electronics, and central signal processing will be presented. We will also describe the major development activities that are presently underway to advance the design.

Direct measurements on imaging riometer antenna array beam directivities

NASA Astrophysics Data System (ADS)

Wilson, A.; Nel, J. J.; Mathews, M. J.; Stoker, P. H.

2001-01-01

Spatial structures in enhanced ionization of the ionosphere are observed by absorption of cosmic radio waves. These structures are resolved by using theoretically derived imaging riometer antenna array directivities. These directivities are calculated from beam phasing of 64 crossed dipole elements of the 38.2-MHz antenna array at SANAE IV, Antarctica. In order to ensure that these derived directivities are representative of the actual viewing directions of the 64-beams, a radio transmitter was flown by helicopter across the antenna array. In this paper variations in the receiver signal strengths, recorded when flying across beam-viewing directions, are compared with the spatial and angular-dependent profiles of expected receiver output responses, derived theoretically from the directivities of the antenna array. A Global Positioning System (GPS) device on board the helicopter was used for positional recording. The derived and recorded profiles did coincide occasionally, but at other instances relative displacements and differences in magnitude of responses were observed. These displacements and differences could be attributed to degradation in position fixes imposed deliberately by selective availability on the GPS system. Excellent coincidence for a number of beam crossings proved that the viewing directions are accurate in all the beam directions, since the multi-dimensional Butler matrix produces 64 simultaneous beams.

Wide-bandwidth high-resolution search for extraterrestrial intelligence

NASA Technical Reports Server (NTRS)

Horowitz, Paul

1995-01-01

Research was accomplished during the third year of the grant on: BETA architecture, an FFT array, a feature extractor, the Pentium array and workstation, and a radio astronomy spectrometer. The BETA (this SETI project) system architecture has been evolving generally in the direction of greater robustness against terrestrial interference. The new design adds a powerful state-memory feature, multiple simultaneous thresholds, and the ability to integrate multiple spectra in a flexible state-machine architecture. The FFT array is reported with regards to its hardware verification, array production, and control. The feature extractor is responsible for maintaining a moving baseline, recognizing large spectral peaks, following the progress of previously identified interesting spectral regions, and blocking signals from regions previously identified as containing interference. The Pentium array consists of 21 Pentium-based PC motherboards, each with 16 MByte of RAM and an Ethernet interface. Each motherboard receives and processes the data from a feature extractor/correlator board set, passing on the results of a first analysis to the central Unix workstation (through which each is also booted). The radio astronomy spectrometer is a technological spinoff from SETI work. It is proposed to be a combined spectrometer and power-accumulator, for use at Arecibo Observatory to search for neutral hydrogen emission from condensations of neutral hydrogen at high redshift (z = 5).

148. ARAIII Reactor building (ARA608) Floor plan. Shows location of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

148. ARA-III Reactor building (ARA-608) Floor plan. Shows location of reactor, heater, and mechanical loop pits; mechanical and electrical equipment rooms; and other work areas. Aerojet-general 880-area/GCRE-608-A-1. Date: February 1958. Ineel index code no. 063-0608-00-013-102612. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

116. ARAI Details of hot cell section of building ARA626. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

116. ARA-I Details of hot cell section of building ARA-626. Shows manipulator openings in operating face of hot cell, start/stop buttons, and other details. Norman Engineering Company 961/area/SF-626-E-6. Date: January 1959. Ineel index code no. 068-0626-10-613-102731. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

111. ARAI Hot cell (ARA626) Building elevations of north, south, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

111. ARA-I Hot cell (ARA-626) Building elevations of north, south, east, and west sides. Includes details of personnel decontamination area, dark room, and other features. Norman Engineering Company: 961-area/SF-626-A-3. Date: January 1959. Ineel index code no. 068-0626-00-613-102723. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

118. ARAI Shop and maintenance (ARA627) building elevations of north, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. ARA-I Shop and maintenance (ARA-627) building elevations of north, south, east, and west sides and other details of door and window types. Norman Engineering Company 961-area/SF-627-A-2. Date: January 1959. Ineel index code no. 068-0627-00-613-102760. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

127. ARAII Administrative and technical support building (ARA606) ground floor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

127. ARA-II Administrative and technical support building (ARA-606) ground floor plan. Indicates use of rooms for classrooms, offices, and lunch room. C.A. Sundberg and Associates 866-area-ALPR-606-A-2. Date: June 1958. Ineel index code no. 070-0606-00-822-102825. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

135. ARAII SLI decontamination and lay down building (ARA614) north, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

135. ARA-II SL-I decontamination and lay down building (ARA-614) north, south, east, and west elevations, floor plan, and detail of doors. F.C. Torkelson Company 842-area/SL-1-614-A-1. Date: September 1960. Ineel index code no. 070-0614-00-851-150061. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Ara

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

(the Altar; abbrev. Ara, gen. Arae; area 237 sq. deg.) A southern constellation that lies between Scorpius and Apus, and culminates at midnight in early June. It is said to represent the altar upon which in Greek mythology the gods swore allegiance before their battle against the Titans, and that upon which Chiron, the centaur, is about to sacrifice Lupus, the wolf (which was a neighboring conste...

167. ARAIII Plot plan as of 1986. Shows most of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

167. ARA-III Plot plan as of 1986. Shows most of original army buildings in addition to location for buildings ARA-621 and ARA-630, which were built in 1969 after army program had been canceled. Date: March 1986. Ineel index code no. 063-0100-00-220-421241. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

158. ARAIII Reactor building (ARA608) Secondary cooling loop and piping ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

158. ARA-III Reactor building (ARA-608) Secondary cooling loop and piping plan. This drawing was selected as a typical example of piping arrangements within reactor building. Aerojet/general 880-area/GCRE-608-P-16. Date: February 1958. INeel index code no. 063-0608-50-013-102641. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Probes of eukaryotic DNA-dependent RNA polymerase II-I. Binding of 9-beta-D-arabinofuranosyl-6-mercaptopurine to the elongation subsite.

PubMed

Cho, J M; Kimball, A P

1982-08-15

9-beta-D-Arabinofuranosyl-6-mercaptopurine (ara-6-MP) was used to affinity-label wheat germ DNA-dependent RNA polymerase II (or B) (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6). This nucleoside analogue was found to be a competitive inhibitor with respect to [3H]UMP incorporation. Natural substrates protected the enzyme from inactivation by ara-6-MP when the enzyme was preincubated with excess concentrations of substrates, suggesting that the inhibitor binds at the elongation subsite. The inhibitor bound the catalytic center of the enzyme with a stoichiometry of 0.6:1. The sulfhydryl reagent, dithiothreitol, reversed the inhibition by ara-6-MP, suggesting that the 6-thiol group of the inhibitor was interacting closely with an essential cysteine residue in the catalytic center of the enzyme. Chromatographic analysis of the pronase-digestion products of the RNA polymerase II-ara-6-MP complex also showed that ara-6-MP had bound a cysteine residue. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the denatured [6-35S]ara-6-MP-labeled RNA polymerase II revealed that over 80% of the radioactivity was associated with the IIb subunit of the enzyme.

N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model.

PubMed

Balci, Yasemin Isik; Acer, Semra; Yagci, Ramazan; Kucukatay, Vural; Sarbay, Hakan; Bozkurt, Kerem; Polat, Aziz

2017-02-01

Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids are one of the prophylactic treatments for keratoconjunctivitis induced by ARA-C. Forty Wistar-type albino rats were included in this study the rats were divided into four groups. The first group (Group 1) received only ARA-C, the second group (Group 2) received ARA-C and N-acetylcysteine (NAC), the third group (Group 3) received only NAC and the fourth group (Group 4) was the control group. The total oxidant status (TOS), the total antioxidant capacity and the oxidative stress index (OSI) measurements of the cornea and the conjunctiva were evaluated in these four groups. The mean TOS and OSI value was the highest in Group 1 and the lowest in Group 3. The differences in TOS and OSI values were statistically significant between Group 1 and Group 2. There are decreases in TOS and OSI values in rats which received ARA-C with NAC administration. NAC may have a protective effect on ARA-C-induced keratoconjunctivitis.

Cytosine arabinoside influx and nucleoside transport sites in acute leukemia.

PubMed

Wiley, J S; Jones, S P; Sawyer, W H; Paterson, A R

1982-02-01

Although cytosine arabinoside (araC) can induce a remission in a majority of patients presenting with acute myeloblastic leukemia (AML), a minority fail to respond and moreover the drug has less effect in acute lymphoblastic leukemia (ALL). The carrier-mediated influx of araC into purified blasts from patients with AML, ALL, and acute undifferentiated leukemia (AUL) has been compared to that of normal lymphocytes and polymorphs. Blasts showed a larger mediated influx of araC than mature cells, since mean influxes for myeloblasts and lymphoblasts were 6- and 2.3-fold greater than polymorphs and lymphocytes, respectively. Also, the mean influx for myeloblasts was fourfold greater than the mean for lymphoblasts. The number of nucleoside transport sites was estimated for each cell type by measuring the equilibrium binding of [(3)H]nitrobenzylthioinosine (NBMPR), which inhibits nucleoside fluxes by binding with high affinity to specific sites on the transport mechanism. The mean binding site numbers for myeloblasts and lymphoblasts were 5- and 2.8-fold greater, respectively, than for the mature cells of the same maturation series. The mean number of NBMPR binding sites for myeloblasts was fourfold greater than for lymphoblasts. Patients with AUL were heterogeneous since blasts from some gave values within the myeloblastic range and others within the lymphoblastic range. The araC influx correlated closely with the number of NBMPR binding sites measured in the same cells on the same day. Transport parameters were measured on blasts from 15 patients with AML or AUL who were then treated with standard induction therapy containing araC. Eight patients entered complete remission, while seven failed therapy, among whom were the three patients with the lowest araC influx (<0.4 pmol/10(7) cells per min) and NBMPR binding (<3,000 sites/cell) for the treated group. In summary, myeloblasts have both higher araC transport rates and more nucleoside transport sites than lymphoblasts and this factor may contribute to the greater sensitivity of AML to this drug. AraC transport varied >10-fold between leukemic blasts and normal leukocytes, but transport capacity related directly to the number of nucleoside transport sites on the cell. Finally, low araC transport rates or few NBMPR binding sites on blasts were observed in a subset of patients with acute leukemia who failed to achieve remission with drug combinations containing araC.

MIT Lincoln Laboratory Facts 2015

DTIC Science & Technology

2015-01-01

this technology to industry for deployment in operational systems. Current efforts focus on radio - frequency (RF) military satellite communications ... frequency submarine communications demonstration ■■ Continuous-wave diode laser developed in InGaAsP/InP alloy ■■ Ground-based Electro-Optical Deep...Radar upgrade ■■ Miniaturized radio - frequency receiver ■■ Missile Alternative Range Target Instrument payloads ■■ Multifunction phased array radar

Radio telescope search for the resonant conversion of cold dark matter axions from the magnetized astrophysical sources

NASA Astrophysics Data System (ADS)

Huang, Fa Peng; Kadota, Kenji; Sekiguchi, Toyokazu; Tashiro, Hiroyuki

2018-06-01

We study the conditions for the adiabatic resonant conversion of the cold dark matter (CDM) axions into photons in the astrophysically sourced strong magnetic fields such as those in the neutron star magnetosphere. We demonstrate the possibility that the forthcoming radio telescopes such as the SKA (Square Kilometre Array) can probe those photon signals from the CDM axions.

Discovery of a Giant Radio Halo in a New Planck Galaxy Cluster PLCKG171.9-40.7

NASA Technical Reports Server (NTRS)

Giacintucci, Simona; Kale, Ruta; Wik, Daniel R.; Venturi, Tiziana; Markevitch, Maxim

2013-01-01

We report the discovery of a giant radio halo in a new, hot, X-ray luminous galaxy cluster recently found by Planck, PLCKG171.9-40.7. The radio halo was found using Giant Metrewave Radio Telescope observations at 235 MHz and 610 MHz, and in the 1.4 GHz data from a NRAO Very Large Array Sky Survey pointing that we have reanalyzed. The diffuse radio emission is coincident with the cluster X-ray emission, has an extent of approx.1 Mpc and a radio power of approx. 5×10(exp 24)W/Hz at 1.4 GHz. Its integrated radio spectrum has a slope of alpha approx. = 1.8 between 235 MHz and 1.4 GHz, steeper than that of a typical giant halo. The analysis of the archival XMMNewton X-ray data shows that the cluster is hot (approx. 10 keV) and disturbed, consistent with X-ray selected clusters hosting radio halos. This is the first giant radio halo discovered in one of the new clusters found by Planck.

EVLA observations of radio-loud quasars selected to study radio orientation

NASA Astrophysics Data System (ADS)

Maithil, Jaya; Brotherton, Michael S.; Runnoe, Jessie; Wardle, John F. C.; DiPompeo, Michael; De Breuck, Carlos; Wills, Beverley J.

2018-06-01

We present preliminary work to develop an unbiased sample of radio-loud quasars to test orientation indicators. We have obtained radio data of 147 radio-loud quasars using EVLA at 10 GHz and with the A-array. With this high-resolution data we have measured the uncontaminated core flux density to determine orientation indicators based on radio core dominance. The radio cores of quasars have a flat spectrum over a broad range of frequencies, so we expect that the core flux density at the FIRST and the observed frequencies should be the same in the absence of variability. Jackson & Brown (2012) pointed out that the survey measurements of core flux density, like FIRST, often doesn't have the spatial resolution to distinguish cores from extended emission. Our measurements show that at FIRST spatial resolution, core flux measurements are indeed systematically high. Our results establish that orientation studies need high-resolution radio data as compared to survey data, and that the optical emission is a better normalization than the extended radio emission for a core dominance parameter to track orientation.

Radio and X-ray structure of Centaurus A

NASA Technical Reports Server (NTRS)

Feigelson, E. D.

1982-01-01

Recent studies of the nearby radio galaxy Centaurus A with the Very Large Array and the Einstein X-Ray Observatory reveal complex radio and X-ray structures. A prominent one-sided jet comprised of resolved knots located 0.2-6 kpc from the nucleus is seen in both radio and X-rays. The X-ray emission is probably synchrotron, requiring in situ reacceleration up to about ten million. Inverse Compton emission is not a likely explanation though a thermal model in which the nucleus ejects dense 100,000 solar mass clouds cannot be excluded. An elongated X-ray region is also found near the 'middle' radio lobe and optical HII regions about 30 kpc NE of the nucleus. Conditions around the active nucleus, the absence of X-rays from the inner radio lobes, and X-ray evidence for a hot interstellar medium are briefly discussed

Simultaneous observations of changes in coronal bright point emission at the 20 cm radio and He Lambda 10830 wavelengths

NASA Technical Reports Server (NTRS)

Habbal, Shadia R.; Harvey, Karen L.

1986-01-01

Preliminary results of observations of solar coronal bright points acquired simultaneously from ground based observatories at the radio wavelength of 20 cm and in the He I wavelength 10830 line on September 8, 1985, are reported. The impetus for obtaining simultaneous radio and optical data is to identify correlations, if any, in changes of the low transition-coronal signatures of bright points with the evolution of the magnetic field, and to distinguish between intermittent heating and changes in the magnetic field topology. Although simultaneous observations of H alpha emission and the photospheric magnetic field at Big Bear were also made, as well as radio observations from Owen Valley Radio Interferometer and Solar Maximum Mission (SSM) (O VIII line), only the comparison between He 10830 and the Very Large Array (VLA) radio data are presented.

Space Telecommunications Radio Systems (STRS) Hardware Architecture Standard: Release 1.0 Hardware Section

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.; Kacpura, Thomas J.; Smith, Carl R.; Liebetreu, John; Hill, Gary; Mortensen, Dale J.; Andro, Monty; Scardelletti, Maximilian C.; Farrington, Allen

2008-01-01

This report defines a hardware architecture approach for software-defined radios to enable commonality among NASA space missions. The architecture accommodates a range of reconfigurable processing technologies including general-purpose processors, digital signal processors, field programmable gate arrays, and application-specific integrated circuits (ASICs) in addition to flexible and tunable radiofrequency front ends to satisfy varying mission requirements. The hardware architecture consists of modules, radio functions, and interfaces. The modules are a logical division of common radio functions that compose a typical communication radio. This report describes the architecture details, the module definitions, the typical functions on each module, and the module interfaces. Tradeoffs between component-based, custom architecture and a functional-based, open architecture are described. The architecture does not specify a physical implementation internally on each module, nor does the architecture mandate the standards or ratings of the hardware used to construct the radios.

Nuclear Radio Jet from a Low-luminosity Active Galactic Nucleus in NGC 4258

NASA Astrophysics Data System (ADS)

Doi, Akihiro; Kohno, Kotaro; Nakanishi, Kouichiro; Kameno, Seiji; Inoue, Makoto; Hada, Kazuhiro; Sorai, Kazuo

2013-03-01

The nearby low-luminosity active galactic nucleus (LLAGN) NGC 4258 has a weak radio continuum component at the galactic center. We investigate its radio spectral properties on the basis of our new observations using the Nobeyama Millimeter Array at 100 GHz and archival data from the Very Large Array at 1.7-43 GHz and the James Clerk Maxwell telescope at 347 GHz. The NGC 4258 nuclear component exhibits (1) an intra-month variable and complicated spectral feature at 5-22 GHz and (2) a slightly inverted spectrum at 5-100 GHz (α ~ 0.3; F νvpropνα) in time-averaged flux densities, which are also apparent in the closest LLAGN M81. These similarities between NGC 4258 and M81 in radio spectral natures in addition to previously known core shift in their AU-scale jet structures produce evidence that the same mechanism drives their nuclei. We interpret the observed spectral property as the superposition of emission spectra originating at different locations with frequency-dependent opacity along the nuclear jet. Quantitative differences between NGC 4258 and M81 in terms of jet/counter jet ratio, radio loudness, and degree of core shift can be consistently understood by fairly relativistic speeds (Γ >~ 3) of jets and their quite different inclinations. The picture established from the two closest LLAGNs is useful for understanding the physical origin of unresolved and flat/inverted spectrum radio cores that are prevalently found in LLAGNs, including Sgr A*, with starved supermassive black holes in the present-day universe.

A generalized measurement equation and van Cittert-Zernike theorem for wide-field radio astronomical interferometry

NASA Astrophysics Data System (ADS)

Carozzi, T. D.; Woan, G.

2009-05-01

We derive a generalized van Cittert-Zernike (vC-Z) theorem for radio astronomy that is valid for partially polarized sources over an arbitrarily wide field of view (FoV). The classical vC-Z theorem is the theoretical foundation of radio astronomical interferometry, and its application is the basis of interferometric imaging. Existing generalized vC-Z theorems in radio astronomy assume, however, either paraxiality (narrow FoV) or scalar (unpolarized) sources. Our theorem uses neither of these assumptions, which are seldom fulfiled in practice in radio astronomy, and treats the full electromagnetic field. To handle wide, partially polarized fields, we extend the two-dimensional (2D) electric field (Jones vector) formalism of the standard `Measurement Equation' (ME) of radio astronomical interferometry to the full three-dimensional (3D) formalism developed in optical coherence theory. The resulting vC-Z theorem enables full-sky imaging in a single telescope pointing, and imaging based not only on standard dual-polarized interferometers (that measure 2D electric fields) but also electric tripoles and electromagnetic vector-sensor interferometers. We show that the standard 2D ME is easily obtained from our formalism in the case of dual-polarized antenna element interferometers. We also exploit an extended 2D ME to determine that dual-polarized interferometers can have polarimetric aberrations at the edges of a wide FoV. Our vC-Z theorem is particularly relevant to proposed, and recently developed, wide FoV interferometers such as Low Frequency Array (LOFAR) and Square Kilometer Array (SKA), for which direction-dependent effects will be important.

Revolutionizing Our Understanding of AGN Feedback and its Importance to Galaxy Evolution in the Era of the Next Generation Very Large Array

NASA Astrophysics Data System (ADS)

Nyland, K.; Harwood, J. J.; Mukherjee, D.; Jagannathan, P.; Rujopakarn, W.; Emonts, B.; Alatalo, K.; Bicknell, G. V.; Davis, T. A.; Greene, J. E.; Kimball, A.; Lacy, M.; Lonsdale, Carol; Lonsdale, Colin; Maksym, W. P.; Molnár, D. C.; Morabito, L.; Murphy, E. J.; Patil, P.; Prandoni, I.; Sargent, M.; Vlahakis, C.

2018-05-01

Energetic feedback by active galactic nuclei (AGNs) plays an important evolutionary role in the regulation of star formation on galactic scales. However, the effects of this feedback as a function of redshift and galaxy properties such as mass, environment, and cold gas content remain poorly understood. The broad frequency coverage (1 to 116 GHz), high sensitivity (up to ten times higher than the Karl G. Jansky Very Large Array), and superb angular resolution (maximum baselines of at least a few hundred kilometers) of the proposed next-generation Very Large Array (ngVLA) are uniquely poised to revolutionize our understanding of AGNs and their role in galaxy evolution. Here, we provide an overview of the science related to AGN feedback that will be possible in the ngVLA era and present new continuum ngVLA imaging simulations of resolved radio jets spanning a wide range of intrinsic extents. We also consider key computational challenges and discuss exciting opportunities for multiwavelength synergy with other next-generation instruments, such as the Square Kilometer Array and the James Webb Space Telescope. The unique combination of high-resolution, large collecting area, and wide frequency range will enable significant advancements in our understanding of the effects of jet-driven feedback on sub-galactic scales, particularly for sources with extents of a few parsec to a few kiloparsec, such as young and/or lower-power radio AGNs, AGNs hosted by low-mass galaxies, radio jets that are interacting strongly with the interstellar medium of the host galaxy, and AGNs at high redshift.

Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy.

PubMed

Liu, Jing; Zhao, Dujuan; He, Wenxiu; Zhang, Huiyuan; Li, Zhonghao; Luan, Yuxia

2017-02-01

The anti-leukemia effect of cytarabine (Ara-C) is severely restricted by its high hydrophilic properties and rapid plasma degradation. Herein, a novel amphiphilic small molecular prodrug of Ara-C was developed by coupling a short aliphatic chain, hexanoic acid (HA) to 4-NH 2 of the parent drug. Based on the amphiphilic nature, the resulting bioconjugate (HA-Ara) could spontaneously self-assemble into stable spherical nanoassemblies (NAs) with an extremely high drug loading (∼71wt%). Moreover, folate receptor (FR)-targeting NAs with high grafting efficient folic acid - bovine serum albumin (FA-BSA) conjugate immobilized on the surface (NAs/FA-BSA) was prepared. The results of MTT assays on FR-positive K562 cells and FR-negative A549 cells demonstrated higher cytotoxicity of HA-Ara NAs than the native drug. Especially, the IC 50 values revealed that NAs/FA-BSA was 3 and 2-fold effective than non-targeted NAs after 24 and 48h treatment with K562 cells, respectively indicating FR-mediated enhanced anti-tumor efficacy. In vitro cellular uptake, larger accumulation of HA-Ara NAs were observed in comparative with the free FITC and the results further confirmed the selective uptake of NAs/FA-BSA in folate receptor enriched cancer cells. Above all, self-assembled HA-Ara NAs exhibited potential superiority for Ara-C delivery and FA-modified NAs would be an excellent candidate for targeting leukemia therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

Magnetic resonance elastography can monitor changes in medullary stiffness in response to treatment in the swine ischemic kidney.

PubMed

Zhang, Xin; Zhu, Xiangyang; Ferguson, Christopher Martyn; Jiang, Kai; Burningham, Tyson; Lerman, Amir; Lerman, Lilach Orly

2018-06-01

Low-energy shockwave (SW) therapy attenuates damage in the stenotic kidney (STK) caused by atherosclerotic renal artery stenosis (ARAS). We hypothesized that magnetic resonance elastography (MRE) would detect attenuation of fibrosis following SW in unilateral ARAS kidneys. Domestic pigs were randomized to control, unilateral ARAS, and ARAS treated with 6 sessions of SW over 3 consecutive weeks (n = 7 each) starting after 3 weeks of ARAS or sham. Four weeks after SW treatment, renal fibrosis was evaluated with MRE in vivo or trichrome staining ex vivo. Blood pressure, single-kidney renal-blood-flow (RBF) and glomerular-filtration-rate (GFR) were assessed. MRE detected increased stiffness in the STK medulla (15.3 ± 2.1 vs. 10.1 ± 0.8 kPa, p < 0.05) that moderately correlated with severity of fibrosis (R 2  = 0.501, p < 0.01), but did not identify mild STK cortical or contralateral kidney fibrosis. Trichrome staining showed that medullary fibrosis was increased in ARAS and alleviated by SW (10.4 ± 1.8% vs. 2.9 ± 0.2%, p < 0.01). SW slightly decreased blood pressure and normalized STK RBF and GFR in ARAS. In the contralateral kidney, SW reversed the increase in RBF and GFR. MRE might be a tool for noninvasive monitoring of medullary fibrosis in response to treatment in kidney disease.

Radio Continuum Surveys with Square Kilometre Array Pathfinders

NASA Astrophysics Data System (ADS)

Norris, Ray P.; Afonso, J.; Bacon, D.; Beck, Rainer; Bell, Martin; Beswick, R. J.; Best, Philip; Bhatnagar, Sanjay; Bonafede, Annalisa; Brunetti, Gianfranco; Budavári, Tamás; Cassano, Rossella; Condon, J. J.; Cress, Catherine; Dabbech, Arwa; Feain, I.; Fender, Rob; Ferrari, Chiara; Gaensler, B. M.; Giovannini, G.; Haverkorn, Marijke; Heald, George; Van der Heyden, Kurt; Hopkins, A. M.; Jarvis, M.; Johnston-Hollitt, Melanie; Kothes, Roland; Van Langevelde, Huib; Lazio, Joseph; Mao, Minnie Y.; Martínez-Sansigre, Alejo; Mary, David; Mcalpine, Kim; Middelberg, E.; Murphy, Eric; Padovani, P.; Paragi, Zsolt; Prandoni, I.; Raccanelli, A.; Rigby, Emma; Roseboom, I. G.; Röttgering, H.; Sabater, Jose; Salvato, Mara; Scaife, Anna M. M.; Schilizzi, Richard; Seymour, N.; Smith, Dan J. B.; Umana, Grazia; Zhao, G.-B.; Zinn, Peter-Christian

2013-03-01

In the lead-up to the Square Kilometre Array (SKA) project, several next-generation radio telescopes and upgrades are already being built around the world. These include APERTIF (The Netherlands), ASKAP (Australia), e-MERLIN (UK), VLA (USA), e-EVN (based in Europe), LOFAR (The Netherlands), MeerKAT (South Africa), and the Murchison Widefield Array. Each of these new instruments has different strengths, and coordination of surveys between them can help maximise the science from each of them. A radio continuum survey is being planned on each of them with the primary science objective of understanding the formation and evolution of galaxies over cosmic time, and the cosmological parameters and large-scale structures which drive it. In pursuit of this objective, the different teams are developing a variety of new techniques, and refining existing ones. To achieve these exciting scientific goals, many technical challenges must be addressed by the survey instruments. Given the limited resources of the global radio-astronomical community, it is essential that we pool our skills and knowledge. We do not have sufficient resources to enjoy the luxury of re-inventing wheels. We face significant challenges in calibration, imaging, source extraction and measurement, classification and cross-identification, redshift determination, stacking, and data-intensive research. As these instruments extend the observational parameters, we will face further unexpected challenges in calibration, imaging, and interpretation. If we are to realise the full scientific potential of these expensive instruments, it is essential that we devote enough resources and careful study to understanding the instrumental effects and how they will affect the data. We have established an SKA Radio Continuum Survey working group, whose prime role is to maximise science from these instruments by ensuring we share resources and expertise across the projects. Here we describe these projects, their science goals, and the technical challenges which are being addressed to maximise the science return.

Photonics applications in high-capacity data link terminals

NASA Astrophysics Data System (ADS)

Shi, Zan; Foshee, James J.

2001-12-01

Radio systems and, in particular, RF data link systems are evolving toward progressively more bandwidth and higher data rates. For many military RF data link applications the data transfer requirements exceed one Gigabit per second. Airborne collectors need to transfer sensor information and other large data files to ground locations and other airborne terminals, including the rel time transfer of files. It is a challenge to the system designer to provide a system design, which meets the RF link budget requirements for a one Gigabit per second data link; and there is a corresponding challenge in the development of the terminal architecture and hardware. The utilization of photonic circuitry and devices as a part of the terminal design offers the designer some alternatives to the conventional RF hardware design within the radio. Areas of consideration for the implementation of photonic technology include Gigabit per second baseband data interfaces with fiber along with the associated clocking rates and extending these Gigabit data rates into the radio for optical processing technology; optical interconnections within the individual circuit boards in the radio; and optical backplanes to allow the transfer of not only the Gigabit per second data rates and high speed clocks but other RF signals within the radio. True time delay using photonics in phased array antennas has been demonstrated and is an alternative to the conventional phase shifter designs used in phased array antennas, and remoting of phased array antennas from the terminal electronics in the Ku and Ka frequency bands using fiber optics as the carrier to minimize the RF losses, negate the use of the conventional waveguides, and allow the terminal equipment to be located with other electronic equipment in the aircraft suitable for controlled environment, ready access, and maintenance. The various photonics design alternatives will be discussed including specific photonic design approaches. Packaging, performance, and affordability of the various design alternatives will also be discussed.

Radio Sources in the NCP Region Observed with the 21 Centimeter Array

NASA Astrophysics Data System (ADS)

Zheng, Qian; Wu, Xiang-Ping; Johnston-Hollitt, Melanie; Gu, Jun-hua; Xu, Haiguang

2016-12-01

We present a catalog of 624 radio sources detected around the North Celestial Pole (NCP) with the 21 Centimeter Array (21CMA), a radio interferometer dedicated to the statistical measurement of the epoch of reionization (EoR). The data are taken from a 12 hr observation made on 2013 April 13, with a frequency coverage from 75 to 175 MHz and an angular resolution of ˜4‧. The catalog includes flux densities at eight sub-bands across the 21CMA bandwidth and provides the in-band spectral indices for the detected sources. To reduce the complexity of interferometric imaging from the so-called “w” term and ionospheric effects, the present analysis is restricted to the east-west baselines within 1500 m only. The 624 radio sources are found within 5° around the NCP down to ˜0.1 Jy. Our source counts are compared, and also exhibit a good agreement, with deep low-frequency observations made recently with the GMRT and MWA. In particular, for fainter radio sources below ˜1 Jy, we find a flattening trend of source counts toward lower frequencies. While the thermal noise (˜0.4 mJy) is well controlled to below the confusion limit, the dynamical range (˜104) and sensitivity of current 21CMA imaging are largely limited by calibration and deconvolution errors, especially the grating lobes of very bright sources, such as 3C061.1, in the NCP field, which result from the regular spacings of the 21CMA. We note that particular attention should be paid to the extended sources, and their modeling and removal may constitute a large technical challenge for current EoR experiments. Our analysis may serve as a useful guide to the design of next generation low-frequency interferometers like the Square Kilometre Array.

ULTRA STEEP SPECTRUM RADIO SOURCES IN THE LOCKMAN HOLE: SERVS IDENTIFICATIONS AND REDSHIFT DISTRIBUTION AT THE FAINTEST RADIO FLUXES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Afonso, J.; Bizzocchi, L.; Grossi, M.

2011-12-20

Ultra steep spectrum (USS) radio sources have been successfully used to select powerful radio sources at high redshifts (z {approx}> 2). Typically restricted to large-sky surveys and relatively bright radio flux densities, it has gradually become possible to extend the USS search to sub-mJy levels, thanks to the recent appearance of sensitive low-frequency radio facilities. Here a first detailed analysis of the nature of the faintest USS sources is presented. By using Giant Metrewave Radio Telescope and Very Large Array radio observations of the Lockman Hole at 610 MHz and 1.4 GHz, a sample of 58 USS sources, with 610more » MHz integrated fluxes above 100 {mu}Jy, is assembled. Deep infrared data at 3.6 and 4.5 {mu}m from the Spitzer Extragalactic Representative Volume Survey (SERVS) are used to reliably identify counterparts for 48 (83%) of these sources, showing an average total magnitude of [3.6]{sub AB} = 19.8 mag. Spectroscopic redshifts for 14 USS sources, together with photometric redshift estimates, improved by the use of the deep SERVS data, for a further 19 objects, show redshifts ranging from z = 0.1 to z = 2.8, peaking at z {approx} 0.6 and tailing off at high redshifts. The remaining 25 USS sources, with no redshift estimate, include the faintest [3.6] magnitudes, with 10 sources undetected at 3.6 and 4.5 {mu}m (typically [3.6] {approx}> 22-23 mag from local measurements), which suggests the likely existence of higher redshifts among the sub-mJy USS population. The comparison with the Square Kilometre Array Design Studies Simulated Skies models indicates that Fanaroff-Riley type I radio sources and radio-quiet active galactic nuclei may constitute the bulk of the faintest USS population, and raises the possibility that the high efficiency of the USS technique for the selection of high-redshift sources remains even at the sub-mJy level.« less

Scalable, efficient ASICS for the square kilometre array: From A/D conversion to central correlation

NASA Astrophysics Data System (ADS)

Schmatz, M. L.; Jongerius, R.; Dittmann, G.; Anghel, A.; Engbersen, T.; van Lunteren, J.; Buchmann, P.

2014-05-01

The Square Kilometre Array (SKA) is a future radio telescope, currently being designed by the worldwide radio-astronomy community. During the first of two construction phases, more than 250,000 antennas will be deployed, clustered in aperture-array stations. The antennas will generate 2.5 Pb/s of data, which needs to be processed in real time. For the processing stages from A/D conversion to central correlation, we propose an ASIC solution using only three chip architectures. The architecture is scalable - additional chips support additional antennas or beams - and versatile - it can relocate its receiver band within a range of a few MHz up to 4GHz. This flexibility makes it applicable to both SKA phases 1 and 2. The proposed chips implement an antenna and station processor for 289 antennas with a power consumption on the order of 600W and a correlator, including corner turn, for 911 stations on the order of 90 kW.

Calibration Errors in Interferometric Radio Polarimetry

NASA Astrophysics Data System (ADS)

Hales, Christopher A.

2017-08-01

Residual calibration errors are difficult to predict in interferometric radio polarimetry because they depend on the observational calibration strategy employed, encompassing the Stokes vector of the calibrator and parallactic angle coverage. This work presents analytic derivations and simulations that enable examination of residual on-axis instrumental leakage and position-angle errors for a suite of calibration strategies. The focus is on arrays comprising alt-azimuth antennas with common feeds over which parallactic angle is approximately uniform. The results indicate that calibration schemes requiring parallactic angle coverage in the linear feed basis (e.g., the Atacama Large Millimeter/submillimeter Array) need only observe over 30°, beyond which no significant improvements in calibration accuracy are obtained. In the circular feed basis (e.g., the Very Large Array above 1 GHz), 30° is also appropriate when the Stokes vector of the leakage calibrator is known a priori, but this rises to 90° when the Stokes vector is unknown. These findings illustrate and quantify concepts that were previously obscure rules of thumb.

Graphene fixed-end beam arrays based on mechanical exfoliation

NASA Astrophysics Data System (ADS)

Li, Peng; You, Zheng; Haugstad, Greg; Cui, Tianhong

2011-06-01

A low-cost mechanical exfoliation method is presented to transfer graphite to graphene for free-standing beam arrays. Nickel film or photoresist is used to peel off and transfer patterned single-layer or multilayer graphene onto substrates with macroscopic continuity. Free-standing graphene beam arrays are fabricated on both silicon and polymer substrates. Their mechanical properties are studied by atomic force microscopy. Finally, a graphene based radio frequency switch is demonstrated, with its pull-in voltage and graphene-silicon junction investigated.

Spectral Indices of Faint Radio Sources

NASA Astrophysics Data System (ADS)

Gim, Hansung B.; Hales, Christopher A.; Momjian, Emmanuel; Yun, Min Su

2015-01-01

The significant improvement in bandwidth and the resultant sensitivity offered by the Karl G. Jansky Very Large Array (VLA) allows us to explore the faint radio source population. Through the study of the radio continuum we can explore the spectral indices of these radio sources. Robust radio spectral indices are needed for accurate k-corrections, for example in the study of the radio - far-infrared (FIR) correlation. We present an analysis of measuring spectral indices using two different approaches. In the first, we use the standard wideband imaging algorithm in the data reduction package CASA. In the second, we use a traditional approach of imaging narrower bandwidths to derive the spectral indices. For these, we simulated data to match the observing parameter space of the CHILES Con Pol survey (Hales et al. 2014). We investigate the accuracy and precision of spectral index measurements as a function of signal-to noise, and explore the requirements to reliably probe possible evolution of the radio-FIR correlation in CHILES Con Pol.

Radio Source Morphology: 'nature or nuture'?

NASA Astrophysics Data System (ADS)

Banfield, Julie; Emonts, Bjorn; O'Sullivan, Shane

2012-10-01

Radio sources, emanating from supermassive black-holes in the centres of active galaxies, display a large variety of morphological properties. It is a long-standing debate to what extent the differences between various types of radio sources are due to intrinsic properties of the central engine (`nature') or due to the properties of the interstellar medium that surrounds the central engine and host galaxy (`nurture'). Settling this `nature vs. nurture' debate for nearby radio galaxies, which can be studied in great detail, is vital for understanding the properties and evolution of radio galaxies throughout the Universe. We propose to observe the radio galaxy NGC 612 where previous observations have detected the presence of a large-scale HI bridge between the host galaxy and a nearby galaxy NGC 619. We request a total of 13 hrs in the 750m array-configuration to determine whether or not the 100 kpc-scale radio source morphology is directly related to the intergalactic distribution of neutral hydrogen gas.

143. ARAIII Control building (ARA607) Floor plan. Shows control room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. ARA-III Control building (ARA-607) Floor plan. Shows control room, contaminated work area, counting and computer room, health physics room, instrument repair room, offices, and other rooms. Aerojet-general 880-area/GCRE-607-A-1. Date: February 1958. Ineel index code no. 063-0607-00-013-102546. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

124. ARAI Reservoir (ARA727), later named water storage tank. Shows ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

124. ARA-I Reservoir (ARA-727), later named water storage tank. Shows plan of 100,000-gallon tank, elevation, image of "danger radiation hazard" sign, and other details. Norman Engineering Company 961-area/SF-727-S-1. Date: January 1959. Ineel index code no. 068-0727-60-613-102779. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

131. ARAII Administration building (ARA613) floor plans for first and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

131. ARA-II Administration building (ARA-613) floor plans for first and second floors. Includes roof plan. Shows use of rooms as offices, laboratory, conference room. F.C. Torkelson Company 842-area/SL-1-613-A-1. Date: October 1958. Ineel index code no. 070-0613-00-851-150718. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

115. ARAI Details of hot cell section of building ARA626. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

115. ARA-I Details of hot cell section of building ARA-626. Shows location of high density concrete, viewing windows, filters, monorail crane, bridge crane, and other details. Norman Engineering Company 961-area/SF-626-MS-1. Date: January 1959. Ineel index code no. 068-0626-40-613-102737. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

ARA type protograph codes

NASA Technical Reports Server (NTRS)

Divsalar, Dariush (Inventor); Abbasfar, Aliazam (Inventor); Jones, Christopher R. (Inventor); Dolinar, Samuel J. (Inventor); Thorpe, Jeremy C. (Inventor); Andrews, Kenneth S. (Inventor); Yao, Kung (Inventor)

2008-01-01

An apparatus and method for encoding low-density parity check codes. Together with a repeater, an interleaver and an accumulator, the apparatus comprises a precoder, thus forming accumulate-repeat-accumulate (ARA codes). Protographs representing various types of ARA codes, including AR3A, AR4A and ARJA codes, are described. High performance is obtained when compared to the performance of current repeat-accumulate (RA) or irregular-repeat-accumulate (IRA) codes.

16. ARAII Administration building ARA613. South (front) and east sides. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. ARA-II Administration building ARA-613. South (front) and east sides. Camera facing northwest. Sign at left corner of building says, "Fuels and materials division, materials joining research and development laboratory." Part of south wall already has been demolished. Sign on roof railing says, "Danger--Abestos." Ineel photo no. 2-3. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

How nitrogen sources influence Mortierella alpina aging: From the lipid droplet proteome to the whole-cell proteome and metabolome.

PubMed

Yu, Yadong; Zhang, Lei; Li, Tao; Wu, Na; Jiang, Ling; Ji, Xiaojun; Huang, He

2018-05-15

Arachidonic acid (ARA) is a valuable polyunsaturated fatty acid produced by Mortierella alpina. Although some strategies such as nitrogen supplementation have shown the potential to affect the aging of M. alpina in ways which enable it to produce more ARA, the underlying mechanism remains elusive. Herein, we conducted a systematical analysis of the lipid droplet proteome, as well as the whole-cell proteome and metabolome, in order to elucidate how and why two different nitrogen sources (KNO 3 and urea) affect the aging of M. alpina and the corresponding ARA concentration. We found that KNO 3 promoted the ARA concentration, while urea accelerated lipid consumption and stimulated the decomposition of mycelia. Although both KNO 3 and urea activated carbohydrate metabolic pathways, KNO 3 exerted a stronger promoting effect on the pentose phosphate pathway and induced the lipid droplets to participate in the citrate-pyruvate cycle. The activities of malic enzyme and isocitrate dehydrogenase were also promoted more by KNO 3 . These pathways provided additional substrates and reducing power for ARA synthesis and ROS elimination. Accordingly, since urea showed a weaker promotion of the related pathways, it caused a depression of the antioxidant system and a consequent increase of ROS. These findings facilitate the design of nitrogen supplementation strategies to achieve higher ARA concentrations, and provide guidance for deciphering the mechanisms of similar aging phenomena in other oleaginous microorganisms. Polyunsaturated fatty acids such as arachidonic acid (ARA) are valuable nutrients, which play important roles in preventing numerous diseases and facilitating development. Although it has been found for years that ARA production will be increased in the aging process of Mortierella alpina (M. alpina) and nitrogen sources are involved in this process, the underlying mechanism for this phenomenon remains unknown. In this work, we used the subcellular proteomics, whole-cell proteomics and metabolomics methods to explore the mechanisms by which two different nitrogen (KNO 3 and urea) affected the aging process of M. alpina. Finally, we gave some new insights for the mechanisms mentioned above. This finding will fuel the technology developments for the ARA production using microbes. Copyright © 2018. Published by Elsevier B.V.

The Impact of Dose and Simultaneous Use of Acid-Reducing Agents on the Effectiveness of Vemurafenib in Metastatic BRAF V600 Mutated Melanoma: a Retrospective Cohort Study.

PubMed

Knapen, Lotte M; Koornstra, Rutger H T; Driessen, Johanna H M; van Vlijmen, Bas; Croes, Sander; Schalkwijk, Stein; Colbers, Angela; Gerritsen, Winald R; Burger, David M; de Vries, Frank; van Erp, Nielka P

2018-04-11

The impact of dose and simultaneous use of acid-reducing agents (ARAs) on the effectiveness of vemurafenib is unknown. To determine the association between progression of metastatic BRAF V600 mutated melanoma and (1) dose reductions of vemurafenib and (2) simultaneous use of vemurafenib and ARAs. A retrospective cohort study of 112 first-line vemurafenib users for melanoma was conducted (March 2012-March 2016), using electronic patient records and pharmacy dispensing records of a Dutch academic hospital. Cox regression analysis was used to estimate the risk of progression with full-dose (n = 64) versus reduced-dose vemurafenib (n = 48) and with simultaneous use of vemurafenib and ARAs (n = 35) versus vemurafenib alone (n = 77). Analyses were adjusted for age and sex. In total, disease progression occurred in 55% of treated patients on vemurafenib, with a median progression-free survival of 6.0 (95% confidence interval [CI] 5.0-6.9) months. Compared to patients on vemurafenib alone, there was no increased risk of progression among patients requiring vemurafenib at a reduced dose or among patients receiving simultaneous therapy with vemurafenib and ARAs. In addition, there was no increased risk of progression among patients who used reduced-dose vemurafenib and ARAs versus those receiving full-dose vemurafenib as sole therapy. However, a tendency for progression was observed among patients who used full-dose vemurafenib and ARAs versus full-dose vemurafenib alone (adjusted hazard ratio [HRa] 2.37; 95% CI 0.97-5.76), which became statistically significant in a sensitivity analysis (HRa 4.56; 95% CI 1.51-13.75). There was no association between the use of vemurafenib in a reduced dose or the simultaneous use of vemurafenib and ARAs and the risk of progression. In addition, there was no association between the simultaneous use of vemurafenib in a reduced dose and ARAs and the risk of progression. However, patients tolerating  full-dose vemurafenib simultaneously with ARAs might have an increased risk of progression. This finding requires prospective validation.

Is 4C+29.48 a γ-ray source?

NASA Astrophysics Data System (ADS)

Gabányi, K. É.; Frey, S.; An, T.

2018-05-01

Context. The Fermi Large Area Telescope revealed that the extragalactic γ-ray sky is dominated by blazars, active galactic nuclei (AGN) whose jet is seen at very small angle to the line of sight. To associate and then classify the γ-ray sources, data have been collected from lower frequency surveys and observations. Since those have superior angular resolution and positional accuracy compared to the γ-ray observations, some associations are not straightforward. Aims: The γ-ray source 3FGL J1323.0+2942 is associated with the radio source 4C+29.48 and classified as a blazar of unknown type, lacking optical spectrum and redshift. The higher-resolution radio data showed that 4C+29.48 comprises three bright radio-emitting features located within a 1'-diameter area. We aim to reveal their nature and pinpoint the origin of the γ-ray emission. Methods: We (re-)analyzed archival Very Large Array (VLA) and unpublished very long baseline interferometry (VLBI) observations conducted by the Very Long Baseline Array (VLBA) and the European VLBI Network of 4C+29.48. We also collected data form optical, infrared and X-ray surveys. Results: According to the VLBI data, the northernmost complex of 4C+29.48 contains a blazar with a high brightness temperature compact core and a steep-spectrum jet feature. The blazar is positionally coincident with an optical source at a redshift of 1.142. Its mid-infrared colors also support its association with a γ-ray emitting blazar. The two other radio complexes have steep radio spectra similar to AGN-related lobes and do not have optical or infrared counterparts in currently available surveys. Based on the radio morphology, they are unlikely to be related to the blazar. There is an optical source between the two radio features, also detected in infrared wavebands. We discuss the possibilities whether the two radio features are lobes of a radio galaxy, or gravitationally lensed images of a background source. Conclusions: We propose to associate the γ-ray source 3FGL J1323.0+2942 in subsequent versions of the Fermi catalog with the blazar residing in northernmost complex. We suggest naming this radio source J1323+2941A to avoid misinterpretation arising from the fact that the coordinates of the currently listed radio counterpart 4C+29.48 is closer to a most probably unrelated radio source.

Synthesis Study of a 6-Element Non-Uniform Array with Tilted Elements for CLARREO Project

NASA Technical Reports Server (NTRS)

Jamnejad, Vahraz; Hoorfar, Ahmad

2012-01-01

This paper presents the results of a preliminary study of the gain/pattern properties of a 6-element Radio Occultation (RO) array for the proposed CLARREO (Climate Absolute Radiance and Refractivity Observatory (CLARREO) Project. CLARREO is one of the 4 highest priority missions recommended in the National Research Council Earth Science Decadal Survey.

Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Abreu, P.; Aglietta, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Cotti, U.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K. D.; Decerprit, G.; Del Peral, L.; Deligny, O.; Dembinski, H.; Denkiewicz, A.; di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fuchs, B.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Gesterling, K.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hague, J. D.; Hansen, P.; Harari, D.; Harmsma, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Hrabovský, M.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jiraskova, S.; Kadija, K.; Kampert, K. H.; Karhan, P.; Karova, T.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; La Rosa, G.; Lachaud, C.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lucero, A.; Ludwig, M.; Lyberis, H.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Mićanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Moura, C. A.; Mueller, S.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Nhung, P. T.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Parrisius, J.; Parsons, R. D.; Pastor, S.; Paul, T.; Pech, M.; PeĶala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Phan, N.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rivera, H.; Riviére, C.; Rizi, V.; Robledo, C.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Salamida, F.; Salazar, H.; Salina, G.; Sánchez, F.; Santander, M.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Schmidt, T.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schroeder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Semikoz, D.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tamashiro, A.; Tapia, A.; Taşcău, O.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tiwari, D. K.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Vargas Cárdenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Warner, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Winders, L.; Winnick, M. G.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Younk, P.; Yuan, G.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Ziolkowski, M.

2011-04-01

The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs “radio-hybrid” measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluorescence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of detector effects, and the read-in of multiple data formats including data from various radio simulation codes. The source code of this radio functionality can be made available to interested parties on request.

An 11-Channel Radio Frequency Phased Array Coil for Magnetic Resonance Guided High Intensity Focused Ultrasound of the Breast

PubMed Central

Minalga, E.; Payne, A.; Merrill, R.; Todd, N.; Vijayakumar, S.; Kholmovski, E.; Parker, D. L.; Hadley, J. R.

2012-01-01

In this study, a radio-frequency (RF) phased array coil was built to image the breast in conjunction with a Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) device designed specifically to treat the breast in a treatment cylinder with reduced water volume. The MRgHIFU breast coil was comprised of a 10-channel phased array coil placed around an MRgHIFU treatment cylinder where nearest-neighbor decoupling was achieved with capacitive decoupling in a shared leg. In addition a single loop coil was placed at the chest wall making a total of 11-channels. The RF coil array design presented in this work was chosen based on ease of implementation, increased visualization into the treatment cylinder, image reconstruction speed, temporal resolution, and resulting signal-to-noise-ratio (SNR) profiles. This work presents a dedicated 11-channel coil for imaging of the breast tissue in the MRgHIFU setup without obstruction of the ultrasound beam and, specifically, compares its performance in SNR, overall imaging time, and temperature measurement accuracy to that of the standard single chest-loop coil typically used in breast MRgHIFU. PMID:22431301

NRAO Teams With NASA Gamma-Ray Satellite

NASA Astrophysics Data System (ADS)

2007-06-01

The National Radio Astronomy Observatory (NRAO) is teaming with NASA's upcoming Gamma-ray Large Area Space Telescope (GLAST) to allow astronomers to use both the orbiting facility and ground-based radio telescopes to maximize their scientific payoff. Under the new, streamlined process, astronomers can compete for coordinated observing time and support from both GLAST and NRAO's radio telescopes. GLAST satellite Artist's rendering of the GLAST spacecraft in orbit above the Earth. CREDIT: General Dynamics C4 Systems Click on Image for Larger File Images of NRAO Telescopes Robert C. Byrd Green Bank Telescope Very Long Baseline Array Very Large Array Atacama Large Millimeter/submillimeter Array GLAST is scheduled for launch no earlier than December 14. It will perform a survey of the entire sky at gamma-ray wavelengths every 3 hours using its primary instrument, the Large Area Telescope (LAT). NRAO operates the Very Large Array (VLA) in New Mexico, the continent-wide Very Long Baseline Array (VLBA), and the Robert C. Byrd Green Bank Telescope (GBT) in West Virginia. The NRAO is a research facility of the National Science Foundation (NSF). "Coordinated gamma-ray and radio observations of celestial objects will greatly enhance the ability to fully understand those objects. Astronomy today requires such multiwavelength studies, and this agreement paves the way for exciting, cutting-edge research," said Fred K.Y. Lo, NRAO Director. GLAST will be vastly more capable than previous gamma-ray satellites, and will carry an instrument, the GLAST Burst Monitor, specifically designed to detect gamma-ray bursts. GLAST observers will study objects such as active galaxies, pulsars, and supernova remnants, which are also readily studied with radio telescopes. By working together, NASA's GLAST mission and NSF's NRAO facilities can study flares from blazars over the widest possible range of energies, which is crucial to understanding how black holes, notorious for drawing matter in, can accelerate jets of material to nearly light speed. "The gamma-ray and radio observations will show scientists different aspects of many still-mysterious objects and processes. By providing a simple procedure for astronomers to win observing time on radio telescopes to follow up on our new gamma-ray discoveries, we're ensuring that we get the maximum scientific return from both," said GLAST project scientist Steve Ritz of NASA's Goddard Space Flight Center in Greenbelt, Md. "The importance of this coordinated approach has been highlighted by a recent two-day workshop at Goddard, in which we discussed the scientific benefits and coordination of radio Very Long Baseline Interferometry observations made in conjunction with GLAST." NRAO's radio telescopes have been used for many years as part of multiwavelength observing programs in conjunction with both ground-based and space-based observatories. Usually, however, astronomers had to submit separate observing proposals to two or more review committees, with no guarantee that they would win observing time on all desired telescopes. For its part, NASA spacecraft such as the Compton Gamma-Ray Observatory and the Chandra X-ray Observatory have opened wide new windows on the high-energy universe. Astronomers, including those on a recent NSF Senior Review panel, have urged reductions in administrative barriers to gaining observing time at multiple wavelengths. "This NRAO-GLAST agreement eases the process of winning observing time on NRAO telescopes to complement the GLAST all-sky gamma-ray survey. In particular, the continent-wide VLBA is the only existing radio telescope that can image and monitor the sites of extreme gamma-ray flares in distant galaxies," said Jim Ulvestad, NRAO's Director for VLA-VLBA Operations. "We expect to see arrangements like this become much more common in the future, to the benefit of the science." The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc. NASA's GLAST mission is an astrophysics and particle physics partnership, developed in collaboration with the U.S. Department of Energy, along with important contributions from academic institutions and partners in France, Germany, Italy, Japan, Sweden, and the U.S.

Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network

PubMed Central

Hwang, Sohyun; Rhee, Seung Y; Marcotte, Edward M; Lee, Insuk

2012-01-01

AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests. PMID:21886106

Accumulate-Repeat-Accumulate-Accumulate Codes

NASA Technical Reports Server (NTRS)

Divsalar, Dariush; Dolinar, Samuel; Thorpe, Jeremy

2007-01-01

Accumulate-repeat-accumulate-accumulate (ARAA) codes have been proposed, inspired by the recently proposed accumulate-repeat-accumulate (ARA) codes. These are error-correcting codes suitable for use in a variety of wireless data-communication systems that include noisy channels. ARAA codes can be regarded as serial turbolike codes or as a subclass of low-density parity-check (LDPC) codes, and, like ARA codes they have projected graph or protograph representations; these characteristics make it possible to design high-speed iterative decoders that utilize belief-propagation algorithms. The objective in proposing ARAA codes as a subclass of ARA codes was to enhance the error-floor performance of ARA codes while maintaining simple encoding structures and low maximum variable node degree.

Implementation of an Antenna Array Signal Processing Breadboard for the Deep Space Network

NASA Technical Reports Server (NTRS)

Navarro, Robert

2006-01-01

The Deep Space Network Large Array will replace/augment 34 and 70 meter antenna assets. The array will mainly be used to support NASA's deep space telemetry, radio science, and navigation requirements. The array project will deploy three complexes in the western U.S., Australia, and European longitude each with 400 12m downlink antennas and a DSN central facility at JPL. THis facility will remotely conduct all real-time monitor and control for the network. Signal processing objectives include: provide a means to evaluate the performance of the Breadboard Array's antenna subsystem; design and build prototype hardware; demonstrate and evaluate proposed signal processing techniques; and gain experience with various technologies that may be used in the Large Array. Results are summarized..

A very deep IRAS survey. III - VLA observations

NASA Astrophysics Data System (ADS)

Hacking, Perry; Condon, J. J.; Houck, J. R.; Beichman, C. A.

1989-04-01

The 60-micron fluxes and positions of sources (primarily starburst galaxies) found in a deep IRAS survey by Hacking and Houck (1987) are compared with 1.49 HGz maps made by the Very Large Array. The radio results are consistent with radio measurements of brighter IRAS galaxies and provide evidence that infrared cirrus does not contaminate the 60-micron sample. The flux-independent ratio of infrared to radio flux densities implies that the 1.4 GHz luminosity function for spiral galaxies is evolving at less than (1 + z) to the power of 4 relative to the 60-micron luminosity function.

Radio emission of SN1993J: the complete picture. II. Simultaneous fit of expansion and radio light curves

NASA Astrophysics Data System (ADS)

Martí-Vidal, I.; Marcaide, J. M.; Alberdi, A.; Guirado, J. C.; Pérez-Torres, M. A.; Ros, E.

2011-02-01

We report on a simultaneous modelling of the expansion and radio light curves of the supernova SN1993J. We developed a simulation code capable of generating synthetic expansion and radio light curves of supernovae by taking into consideration the evolution of the expanding shock, magnetic fields, and relativistic electrons, as well as the finite sensitivity of the interferometric arrays used in the observations. Our software successfully fits all the available radio data of SN 1993J with a standard emission model for supernovae, which is extended with some physical considerations, such as an evolution in the opacity of the ejecta material, a radial decline in the magnetic fields within the radiating region, and a changing radial density profile for the circumstellar medium starting from day 3100 after the explosion.

A symbiotic approach to SETI observations: use of maps from the Westerbork Synthesis Radio Telescope

NASA Technical Reports Server (NTRS)

Tarter, J. C.; Israel, F. P.

1982-01-01

High spatial resolution continuum radio maps produced by the Westerbork Synthesis Radio Telescope (WSRT) of The Netherlands at frequencies near the 21 cm HI line have been examined for anomalous sources of emmission coincident with the locations of nearby bright stars. From a total of 542 stellar positions investigated, no candidates for radio stars or ETI signals were discovered to formal limits on the minimum detectable signal ranging from 7.7 x 10(-22) W/m2 to 6.4 x 10(-24) W/m2. This preliminary study has verified that data collected by radio astronomers at large synthesis arrays can profitably be analysed for SETI signals (in a non-interfering manner) provided only that the data are available in the form of a more or less standard two dimensional map format.

A symbiotic approach to SETI observations: use of maps from the Westerbork Synthesis Radio Telescope.

PubMed

Tarter, J C; Israel, F P

1982-01-01

High spatial resolution continuum radio maps produced by the Westerbork Synthesis Radio Telescope (WSRT) of The Netherlands at frequencies near the 21 cm HI line have been examined for anomalous sources of emmission coincident with the locations of nearby bright stars. From a total of 542 stellar positions investigated, no candidates for radio stars or ETI signals were discovered to formal limits on the minimum detectable signal ranging from 7.7 x 10(-22) W/m2 to 6.4 x 10(-24) W/m2. This preliminary study has verified that data collected by radio astronomers at large synthesis arrays can profitably be analysed for SETI signals (in a non-interfering manner) provided only that the data are available in the form of a more or less standard two dimensional map format.

ATCA radio detection of the new X-ray transient MAXI J1813-095 as a candidate radio-quiet black hole X-ray binary

NASA Astrophysics Data System (ADS)

Russell, T. D.; Miller-Jones, J. C. A.; Sivakoff, G. R.; Tetarenko, A. J.; JACPOT XRB Collaboration

2018-02-01

We observed the new X-ray transient MAXI J1813-095 (ATels #11323, #11326, #11332) with the Australia Telescope Compact Array (ATCA) between 2018-02-22 20:52 UT and 2018-02-23 02:59 UT. Our observations were taken simultaneously at 5.5 and 9 GHz, with a bandwidth of 2 GHz at each frequency.

VizieR Online Data Catalog: CNSS pilot survey (Mooley+, 2016)

NASA Astrophysics Data System (ADS)

Mooley, K. P.; Hallinan, G.; Bourke, S.; Horesh, A.; Myers, S. T.; Frail, D. A.; Kulkarni, S. R.; Levitan, D. B.; Kasliwal, M. M.; Cenko, S. B.; Cao, Y.; Bellm, E.; Laher, R. R.

2017-11-01

The radio observations were carried out across four epochs (E1-E4) with the Jansky VLA in B array configuration, and S band was chosen to maximize survey speed. The optical survey, designed to be contemporaneous with the radio survey, was carried out with the 1.2-m (48-inch) Samuel Oschin Telescope at the Palomar Observatory as part of the Palomar Transient Factory (PTF). (1 data file).

In vitro fermentation of juçara pulp (Euterpe edulis) by human colonic microbiota.

PubMed

Guergoletto, Karla Bigetti; Costabile, Adele; Flores, Gema; Garcia, Sandra; Gibson, Glenn R

2016-04-01

This study was carried out to investigate the potential fermentation properties of juçara pulp, using pH-controlled anaerobic batch cultures reflective of the distal region of the human large intestine. Effects upon major groups of the microbiota were monitored over 24h incubations by fluorescence in situ hybridisation (FISH). Short-chain fatty acids (SCFA) were measured by HPLC. Phenolic compounds, during an in vitro simulated digestion and fermentation, were also analysed. Juçara pulp can modulate the intestinal microbiota in vitro, promoting changes in the relevant microbial populations and shifts in the production of SCFA. Fermentation of juçara pulp resulted in a significant increase in numbers of bifidobacteria after a 24h fermentation compared to a negative control. After in vitro digestion, 46% of total phenolic content still remained. This is the first study reporting the potential prebiotic effect of juçara pulp; however, human studies are necessary to prove its efficacy. Copyright © 2015 Elsevier Ltd. All rights reserved.

Liquid human milk fortifier significantly improves docosahexaenoic and arachidonic acid status in preterm infants.

PubMed

Berseth, C L; Harris, C L; Wampler, J L; Hoffman, D R; Diersen-Schade, D A

2014-09-01

We report the fatty acid composition of mother׳s own human milk from one of the largest US cohorts of lactating mothers of preterm infants. Milk fatty acid data were used as a proxy for intake at enrollment in infants (n=150) who received human milk with a powder human milk fortifier (HMF; Control) or liquid HMF [LHMF; provided additional 12mg docosahexaenoic acid (DHA), 20mg arachidonic acid (ARA)/100mL human milk]. Mothers provided milk samples (n=129) and reported maternal DHA consumption (n=128). Infant blood samples were drawn at study completion (Study Day 28). Human milk and infant PPL fatty acids were analyzed using capillary column gas chromatography. DHA and ARA were within ranges previously published for US term and preterm human milk. Compared to Control HMF (providing no DHA or ARA), human milk fortified with LHMF significantly increased infant PPL DHA and ARA and improved preterm infant DHA and ARA status. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Wastewater recycling technology for fermentation in polyunsaturated fatty acid production.

PubMed

Song, Xiaojin; Ma, Zengxin; Tan, Yanzhen; Zhang, Huidan; Cui, Qiu

2017-07-01

To reduce fermentation-associated wastewater discharge and the cost of wastewater treatment, which further reduces the total cost of DHA and ARA production, this study first analyzed the composition of wastewater from Aurantiochytrium (DHA) and Mortierella alpina (ARA) fermentation, after which wastewater recycling technology for these fermentation processes was developed. No negative effects of DHA and ARA production were observed when the two fermentation wastewater methods were cross-recycled. DHA and ARA yields were significantly inhibited when the wastewater from the fermentation process was directly reused. In 5-L fed-batch fermentation experiments, using this cross-recycle technology, the DHA and ARA yields were 30.4 and 5.13gL -1 , respectively, with no significant changes (P>0.05) compared to the control group, and the water consumption was reduced by half compared to the traditional process. Therefore, this technology has great potential in industrial fermentation for polyunsaturated fatty acid production. Copyright © 2017 Elsevier Ltd. All rights reserved.

Comparison of Exposures Among Arab American and Non-Hispanic White Female Thyroid Cancer Cases in Metropolitan Detroit

PubMed Central

Peterson, L.; Soliman, A.; Ruterbusch, J. J.; Smith, N.

2013-01-01

Arab American (ArA) women may be at greater risk for thyroid cancer (TC) than White women. This case-case comparison explored differences in known and proposed risk factors of TC among ArA and non-Hispanic White (NHW) female TC cases in metropolitan Detroit. Cases of invasive TC identified from a population-based registry responded to a telephone survey regarding potential TC risk factors. Thirty ArA women (response rate 52%) and 70 NHW women (67%) participated. NHW women reported significantly more prior thyroid disease (TD), family history of TD, hormone use, cumulative years of hormone use, cigarette and alcohol consumption. In adjusted logistic regression analysis, ArA women had significantly higher odds of exposure to dental x-rays (OR = 3.48, CI 1.01–12.00) and medical radiation (OR = 13.58, CI 1.49–124.04) than NHW women. Risk factors for TC may differ among ArA women and their NHW counterparts. PMID:21647624

Comparison of exposures among Arab American and non-Hispanic White female thyroid cancer cases in metropolitan Detroit.

PubMed

Peterson, L; Soliman, A; Ruterbusch, J J; Smith, N; Schwartz, K

2011-12-01

Arab American (ArA) women may be at greater risk for thyroid cancer (TC) than White women. This case-case comparison explored differences in known and proposed risk factors of TC among ArA and non-Hispanic White (NHW) female TC cases in metropolitan Detroit. Cases of invasive TC identified from a population-based registry responded to a telephone survey regarding potential TC risk factors. Thirty ArA women (response rate 52%) and 70 NHW women (67%) participated. NHW women reported significantly more prior thyroid disease (TD), family history of TD, hormone use, cumulative years of hormone use, cigarette and alcohol consumption. In adjusted logistic regression analysis, ArA women had significantly higher odds of exposure to dental x-rays (OR = 3.48, CI 1.01-12.00) and medical radiation (OR = 13.58, CI 1.49-124.04) than NHW women. Risk factors for TC may differ among ArA women and their NHW counterparts.

Mechanism of Arachidonic Acid Accumulation during Aging in Mortierella alpina: A Large-Scale Label-Free Comparative Proteomics Study.

PubMed

Yu, Yadong; Li, Tao; Wu, Na; Ren, Lujing; Jiang, Ling; Ji, Xiaojun; Huang, He

2016-11-30

Arachidonic acid (ARA) is an important polyunsaturated fatty acid having various beneficial physiological effects on the human body. The aging of Mortierella alpina has long been known to significantly improve ARA yield, but the exact mechanism is still elusive. Herein, multiple approaches including large-scale label-free comparative proteomics were employed to systematically investigate the mechanism mentioned above. Upon ultrastructural observation, abnormal mitochondria were found to aggregate around shrunken lipid droplets. Proteomics analysis revealed a total of 171 proteins with significant alterations of expression during aging. Pathway analysis suggested that reactive oxygen species (ROS) were accumulated and stimulated the activation of the malate/pyruvate cycle and isocitrate dehydrogenase, which might provide additional NADPH for ARA synthesis. EC 4.2.1.17-hydratase might be a key player in ARA accumulation during aging. These findings provide a valuable resource for efforts to further improve the ARA content in the oil produced by aging M. alpina.

Cosmic ray measurements with LOPES: Status and recent results

NASA Astrophysics Data System (ADS)

Schröder, F. G.; Apel, W. D.; Arteaga-Velázquez, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Fuchs, B.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Zabierowski, J.; Zensus, J. A.

2013-05-01

LOPES is a digital antenna array at the Karlsruhe Institute of Technology, Germany, for cosmic-ray air-shower measurements. Triggered by the co-located KASCADE-Grande air-shower array, LOPES detects the radio emission of air showers via digital radio interferometry. We summarize the status of LOPES and recent results. In particular, we present an update on the reconstruction of the primary-particle properties based on almost 500 events above 100PeV. With LOPES, the arrival direction can be reconstructed with a precision of at least 0.65°, and the energy with a precision of at least 20%, which, however, does not include systematic uncertainties on the absolute energy scale. For many particle and astrophysics questions the reconstruction of the atmospheric depth of the shower maximum, Xmax, is important, since it yields information on the type of the primary particle and its interaction with the atmosphere. Recently, we found experimental evidence that the slope of the radio lateral distribution is indeed sensitive to the longitudinal development of the air shower, but unfortunately, the Xmax precision at LOPES is limited by the high level of anthropogenic radio background. Nevertheless, the developed methods can be transferred to next generation experiments with lower background, which should provide an Xmax precision competitive to other detection technologies.

Genetic programming applied to RFI mitigation in radio astronomy

NASA Astrophysics Data System (ADS)

Staats, K.

2016-12-01

Genetic Programming is a type of machine learning that employs a stochastic search of a solutions space, genetic operators, a fitness function, and multiple generations of evolved programs to resolve a user-defined task, such as the classification of data. At the time of this research, the application of machine learning to radio astronomy was relatively new, with a limited number of publications on the subject. Genetic Programming had never been applied, and as such, was a novel approach to this challenging arena. Foundational to this body of research, the application Karoo GP was developed in the programming language Python following the fundamentals of tree-based Genetic Programming described in "A Field Guide to Genetic Programming" by Poli, et al. Karoo GP was tasked with the classification of data points as signal or radio frequency interference (RFI) generated by instruments and machinery which makes challenging astronomers' ability to discern the desired targets. The training data was derived from the output of an observation run of the KAT-7 radio telescope array built by the South African Square Kilometre Array (SKA-SA). Karoo GP, kNN, and SVM were comparatively employed, the outcome of which provided noteworthy correlations between input parameters, the complexity of the evolved hypotheses, and performance of raw data versus engineered features. This dissertation includes description of novel approaches to GP, such as upper and lower limits to the size of syntax trees, an auto-scaling multiclass classifier, and a Numpy array element manager. In addition to the research conducted at the SKA-SA, it is described how Karoo GP was applied to fine-tuning parameters of a weather prediction model at the South African Astronomical Observatory (SAAO), to glitch classification at the Laser Interferometer Gravitational-wave Observatory (LIGO), and to astro-particle physics at The Ohio State University.

First Results From High-Resolution Front End Electronics for Water Cherenkov Air Shower Detectors Equipped With Cyclone® V FPGA

NASA Astrophysics Data System (ADS)

Szadkowski, Zbigniew

2016-06-01

The paper presents first results from the Front-End Board (FEB) with the biggest Cyclone® V E FPGA 5CEFA9F31I7N, supporting 8 channels sampled up to 250 MSps @ 14-bit resolution. Considered sampling for the planned upgrade of the Pierre Auger surface detector array is 120 MSps, however, the FEB has been developed with external anti-aliasing filters to keep a maximal flexibility. Six channels are targeted to the SD, two the rest for other experiments like: Auger Engineering Radio Array and additional muon counters. More channels and higher sampling generate larger size of registered events. We used the standard radio channel for a radio transmission from the detectors to the Central Data Acquisition Station (CDAS) to avoid at present a significant modification of a software in both sides: the detector and the CDAS (planned in a future for a final design). Several variants of the FPGA code were tested for 120, 160, 200 and even 240 MSps DAQ. Tests confirmed a stability and reliability of the FEB design in real pampas conditions with more than 40°C daily temperature variation and a strong sun exposition with a limited power budget only from a single solar panel. Seven FEBs have been deployed in a hexagon of test detectors on a dedicated Engineering Array.

Cosmic non-TEM radiation and synthetic feed array sensor system in ASIC mixed signal technology

NASA Astrophysics Data System (ADS)

Centureli, F.; Scotti, G.; Tommasino, P.; Trifiletti, A.; Romano, F.; Cimmino, R.; Saitto, A.

2014-08-01

The paper deals with the opportunity to introduce "Not strictly TEM waves" Synthetic detection Method (NTSM), consisting in a Three Axis Digital Beam Processing (3ADBP), to enhance the performances of radio telescope and sensor systems. Current Radio Telescopes generally use the classic 3D "TEM waves" approximation Detection Method, which consists in a linear tomography process (Single or Dual axis beam forming processing) neglecting the small z component. The Synthetic FEED ARRAY three axis Sensor SYSTEM is an innovative technique using a synthetic detection of the generic "NOT strictly TEM Waves radiation coming from the Cosmo, which processes longitudinal component of Angular Momentum too. Than the simultaneous extraction from radiation of both the linear and quadratic information component, may reduce the complexity to reconstruct the Early Universe in the different requested scales. This next order approximation detection of the observed cosmologic processes, may improve the efficacy of the statistical numerical model used to elaborate the same information acquired. The present work focuses on detection of such waves at carrier frequencies in the bands ranging from LF to MMW. The work shows in further detail the new generation of on line programmable and reconfigurable Mixed Signal ASIC technology that made possible the innovative Synthetic Sensor. Furthermore the paper shows the ability of such technique to increase the Radio Telescope Array Antenna performances.

134. ARAII SL1 decontamination and lay down building (ARA614) erected ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

134. ARA-II SL-1 decontamination and lay down building (ARA-614) erected after accidental explosion of SL-1 reactor. Shows vicinity map, index of related drawings, plot plan and other detail. F.C. Torkelson Company 842-area/SL-1-101-U-2. Date: September 1962. Ineel index code no. 070-0101-65-851-150713. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

122. ARAI Pump House (ARA629). Drawing shows north, south, east, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

122. ARA-I Pump House (ARA-629). Drawing shows north, south, east, and west elevations, floor plan, foundation plan, and other details. Note small enclosure at southwest corner of building to contain chlorination equipment. Norman Engineering Company 961-area/SF-629-A-1. Date: January 1959. Ineel index code no. 068-0629-00-613-102774. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

L-arabinose fermenting yeast

DOEpatents

Zhang, Min; Singh, Arjun; Knoshaug, Eric; Franden, Mary Ann; Jarvis, Eric; Suominen, Pirkko

2010-12-07

An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains. ##STR00001##

Peanut digestome: Identification of digestion resistant IgE binding peptides.

PubMed

Di Stasio, Luigia; Picariello, Gianluca; Mongiello, Mariantonietta; Nocerino, Rita; Berni Canani, Roberto; Bavaro, Simona; Monaci, Linda; Ferranti, Pasquale; Mamone, Gianfranco

2017-09-01

Stability to proteolytic degradation in the digestive tract is considered a general feature shared by most food allergens. Current digestibility models exclusively utilize purified allergen proteins, neglecting the relevant effects of matrix that occur for foodstuff systems. In the present study, we investigated digestion stability of the major peanut allergens directly in the natural matrix using an in vitro static model that simulates the gastrointestinal digestion including the oral, gastric, duodenal and intestinal (brush border membrane enzymes) phases. Immunogenicity was evaluated by Western Blot using N=8 pooled sera of peanut allergic pediatric subjects. Immunoreactive, large-sized and fragments of Ara h 2, Ara h 6 and Ara h 3 survived hydrolysis as assessed by SDS-PAGE. Smaller resistant peptides mainly arising from Ara h 3 and also Ara h 1 were detected and further identified by LC-high resolution-MS/MS. RP-HPLC purification followed by dot-blot analysis and MS/MS-based identification demonstrated that stable IgE-binding peptides derived from Ara h 3. These results provide a more realistic picture of the potentially allergenic determinants of peanuts that survived the human digestion, taking into account the role of the food matrix, which may significantly affect gastrointestinal breakdown of peanut allergens. Copyright © 2017 Elsevier Ltd. All rights reserved.

realfast: Real-time, Commensal Fast Transient Surveys with the Very Large Array

NASA Astrophysics Data System (ADS)

Law, C. J.; Bower, G. C.; Burke-Spolaor, S.; Butler, B. J.; Demorest, P.; Halle, A.; Khudikyan, S.; Lazio, T. J. W.; Pokorny, M.; Robnett, J.; Rupen, M. P.

2018-05-01

Radio interferometers have the ability to precisely localize and better characterize the properties of sources. This ability is having a powerful impact on the study of fast radio transients, where a few milliseconds of data is enough to pinpoint a source at cosmological distances. However, recording interferometric data at millisecond cadence produces a terabyte-per-hour data stream that strains networks, computing systems, and archives. This challenge mirrors that of other domains of science, where the science scope is limited by the computational architecture as much as the physical processes at play. Here, we present a solution to this problem in the context of radio transients: realfast, a commensal, fast transient search system at the Jansky Very Large Array. realfast uses a novel architecture to distribute fast-sampled interferometric data to a 32-node, 64-GPU cluster for real-time imaging and transient detection. By detecting transients in situ, we can trigger the recording of data for those rare, brief instants when the event occurs and reduce the recorded data volume by a factor of 1000. This makes it possible to commensally search a data stream that would otherwise be impossible to record. This system will search for millisecond transients in more than 1000 hr of data per year, potentially localizing several Fast Radio Bursts, pulsars, and other sources of impulsive radio emission. We describe the science scope for realfast, the system design, expected outcomes, and ways in which real-time analysis can help in other fields of astrophysics.

Radio Follow-up on All Unassociated Gamma-Ray Sources from the Third Fermi Large Area Telescope Source Catalog

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schinzel, Frank K.; Petrov, Leonid; Taylor, Gregory B.

The third Fermi Large Area Telescope γ -ray source catalog (3FGL) contains over 1000 objects for which there is no known counterpart at other wavelengths. The physical origin of the γ -ray emission from those objects is unknown. Such objects are commonly referred to as unassociated and mostly do not exhibit significant γ -ray flux variability. We performed a survey of all unassociated γ -ray sources found in 3FGL using the Australia Telescope Compact Array and Very Large Array in the range 4.0–10.0 GHz. We found 2097 radio candidates for association with γ -ray sources. The follow-up with very longmore » baseline interferometry for a subset of those candidates yielded 142 new associations with active galactic nuclei that are γ -ray sources, provided alternative associations for seven objects, and improved positions for another 144 known associations to the milliarcsecond level of accuracy. In addition, for 245 unassociated γ -ray sources we did not find a single compact radio source above 2 mJy within 3 σ of their γ -ray localization. A significant fraction of these empty fields, 39%, are located away from the Galactic plane. We also found 36 extended radio sources that are candidates for association with a corresponding γ -ray object, 19 of which are most likely supernova remnants or H ii regions, whereas 17 could be radio galaxies.« less

[An encounter with extraterrestrial intelligence].

PubMed

Hisabayashi, Hisashi

2003-12-01

It is much easier to find extraterrestrial intelligence than to detect simple organisms living on other planets. However, it is hard to communicate with such intelligence without the mutual understanding of inter-stellar communication protocol. The radio SETI (The Search for Extra-Terrestrial Intelligence) was initiated with the pioneering work of F. Drake in 1960, one year after the historical SETI paper by Cocconi and Morrison. This talk explains that SETI evolves with two bases of science; the understanding of our universe and the development of technology. Since SETI has had strong connection with radio astronomy from its early beginning, the impacts of radio astronomical findings and technological breakthrough can be seen in many aspects of the SETI history. Topics of this talk include the detection of microwave 3 K background radiation in the universe. Interstellar atomic and molecular lines found in radio-wave spectra provide the evidence of pre-biotic chemical evolution in such region. Radio telescope imaging and spectral technique are closely associated with methodology of SETI. Topics of the talk extend to new Allen Telescope Array and projected Square Kilometer Array. Recent optical SETI and the discoveries of extra solar planets are also explained. In the end, the recent understanding of our universe is briefly introduced in terms of matter, dark matter and dark energy. Even our understanding of the universe has been evolutionarily revolved and accumulated after 1960, we must recognize that our universe is still poorly understood and that astronomy and SETI are required to proceed hand in hand.

Report of the Working Design Group

NASA Technical Reports Server (NTRS)

1992-01-01

The engineering study group in the LOUISA workshop was responsible for producing a preliminary general design for an optical synthetic aperture telescope on the Moon. This design is intended to be a test case for focusing continuing design studies. The scope of the design included consideration of the array geometry, individual telescopes, metrology, site attributes, and construction. However, no attempt was made to go into further depth in the design than to cover the essential characteristics of the instrument. The starting point for the array design was the lunar optical array discussed by Burke (1985). His array geometry followed the design and correlation procedure of the 27-element Very Large Array (VLA) radio telescopes near Socorro, New Mexico.

Distribution of peanut allergen in the environment.

PubMed

Perry, Tamara T; Conover-Walker, Mary Kay; Pomés, Anna; Chapman, Martin D; Wood, Robert A

2004-05-01

Patients with peanut allergy can have serious reactions to very small quantities of peanut allergen and often go to extreme measures to avoid potential contact with this allergen. The purpose of this study was to detect peanut allergen under various environmental conditions and examine the effectiveness of cleaning agents for allergen removal. A monoclonal-based ELISA for Arachis hypogaea allergen 1 (Ara h 1; range of detection, 30-2000 ng/mL) was used to assess peanut contamination on cafeteria tables and other surfaces in schools, the presence of residual peanut protein after using various cleaning products on hands and tabletops, and airborne peanut allergen during the consumption of several forms of peanut. After hand washing with liquid soap, bar soap, or commercial wipes, Ara h 1 was undetectable. Plain water and antibacterial hand sanitizer left detectable Ara h 1 on 3 of 12 and 6 of 12 hands, respectively. Common household cleaning agents removed peanut allergen from tabletops, except dishwashing liquid, which left Ara h 1 on 4 of 12 tables. Of the 6 area preschools and schools evaluated, Ara h 1 was found on 1 of 13 water fountains, 0 of 22 desks, and 0 of 36 cafeteria tables. Airborne Ara h 1 was undetectable in simulated real-life situations when participants consumed peanut butter, shelled peanuts, and unshelled peanuts. The major peanut allergen, Ara h 1, is relatively easily cleaned from hands and tabletops with common cleaning agents and does not appear to be widely distributed in preschools and schools. We were not able to detect airborne allergen in many simulated environments.

Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants.

PubMed

Hoffman, Dennis; Ziegler, Ekhard; Mitmesser, Susan H; Harris, Cheryl L; Diersen-Schade, Deborah A

2008-01-01

Healthy term infants (n = 244) were randomized to receive: (1) control, soy-based formula without supplementation or (2) docosahexaenoic acid-arachidonic acid (DHA + ARA), soy-based formula supplemented with at least 17 mg DHA/100 kcal (from algal oil) and 34 mg ARA/100 kcal (from fungal oil) in a double-blind, parallel group trial to evaluate safety, benefits, and growth from 14 to 120 days of age. Anthropometric measurements were taken at 14, 30, 60, 90, and 120 days of age and 24-h dietary and tolerance recall were recorded at 30, 60, 90, and 120 days of age. Adverse events were recorded throughout the study. Blood samples were drawn from subsets of 25 infants in each group. Capillary column gas chromatography was used to analyze the percentages of fatty acids in red blood cell (RBC) lipids and plasma phospholipids. Compared with the control group, percentages of fatty acids such as DHA and ARA in total RBC and plasma phospholipids were significantly higher in infants in the DHA + ARA group at 120 days of age (P < 0.001). Growth rates did not differ significantly between feeding groups at any assessed time point. Supplementation did not affect the tolerance of formula or the incidence of adverse events. Feeding healthy term infants soy-based formula supplemented with DHA and ARA from single cell oil sources at concentrations similar to human milk significantly increased circulating levels of DHA and ARA when compared with the control group. Both formulas supported normal growth and were well tolerated.

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3;#8242;-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Egli, Martin; Pallan, Pradeep S.; Allerson, Charles R.

The synthesis, biophysical, structural, and biological properties of both isomers of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides are reported. Synthesis of the FHNA and Ara-FHNA thymine phosphoramidites was efficiently accomplished starting from known sugar precursors. Optimal RNA affinities were observed with a 3'-fluorine atom and nucleobase in a trans-diaxial orientation. The Ara-FHNA analog with an equatorial fluorine was found to be destabilizing. However, the magnitude of destabilization was sequence-dependent. Thus, the loss of stability is sharply reduced when Ara-FHNA residues were inserted at pyrimidine-purine (Py-Pu) steps compared to placement within a stretch of pyrimidines (Py-Py). Crystal structuresmore » of A-type DNA duplexes modified with either monomer provide a rationalization for the opposing stability effects and point to a steric origin of the destabilization caused by the Ara-FHNA analog. The sequence dependent effect can be explained by the formation of an internucleotide C-F {hor_ellipsis} H-C pseudo hydrogen bond between F3' of Ara-FHNA and C8-H of the nucleobase from the 3'-adjacent adenosine that is absent at Py-Py steps. In animal experiments, FHNA-modified antisense oligonucleotides formulated in saline showed a potent downregulation of gene expression in liver tissue without producing hepatotoxicity. Our data establish FHNA as a useful modification for antisense therapeutics and also confirm the stabilizing influence of F(Py) {hor_ellipsis} H-C(Pu) pseudo hydrogen bonds in nucleic acid structures.« less

Arachidonic acid and DHA status in pregnant women is not associated with cognitive performance of their children at 4 or 6-7 years.

PubMed

Crozier, Sarah R; Sibbons, Charlene M; Fisk, Helena L; Godfrey, Keith M; Calder, Philip C; Gale, Catharine R; Robinson, Sian M; Inskip, Hazel M; Baird, Janis; Harvey, Nicholas C; Cooper, Cyrus; Burdge, Graham C

2018-06-01

Arachidonic acid (ARA) and DHA, supplied primarily from the mother, are required for early development of the central nervous system. Thus, variations in maternal ARA or DHA status may modify neurocognitive development. We investigated the relationship between maternal ARA and DHA status in early (11·7 weeks) or late (34·5 weeks) pregnancy on neurocognitive function at the age of 4 years or 6-7 years in 724 mother-child pairs from the Southampton Women's Survey cohort. Plasma phosphatidylcholine fatty acid composition was measured in early and late pregnancy. ARA concentration in early pregnancy predicted 13 % of the variation in ARA concentration in late pregnancy (β=0·36, P<0·001). DHA concentration in early pregnancy predicted 21 % of the variation in DHA concentration in late pregnancy (β=0·46, P<0·001). Children's cognitive function at the age of 4 years was assessed by the Wechsler Preschool and Primary Scale of Intelligence and at the age of 6-7 years by the Wechsler Abbreviated Scale of Intelligence. Executive function at the age of 6-7 years was assessed using elements of the Cambridge Neuropsychological Test Automated Battery. Neither DHA nor ARA concentrations in early or late pregnancy were associated significantly with neurocognitive function in children at the age of 4 years or the age of 6-7 years. These findings suggest that ARA and DHA status during pregnancy in the range found in this cohort are unlikely to have major influences on neurocognitive function in healthy children.

Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets.

PubMed

Wijendran, Vasuki; Downs, Ian; Srigley, Cynthia Tyburczy; Kothapalli, Kumar S D; Park, Woo Jung; Blank, Bryant S; Zimmer, J Paul; Butt, C M; Salem, Norman; Brenna, J Thomas

2013-10-01

Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined. The objective of the current study was to determine regulation of liver Fads1, Fads2 and Fads3 classical (CS) and alternative transcripts (AT) expression by dietary ARA and DHA, within the physiological range present in human breast milk, in suckling piglets. Piglets were fed one of six milk replacer formula diets (formula-reared groups, FR) with varying ARA and DHA content from days 3-28 of age. The ARA/DHA levels of the six formula diets were as follows (% total fatty acid, FA/FA): (A1) 0.1/1.0; (A2) 0.53/1.0; (A3-D3) 0.69/1.0; (A4) 1.1/1.0; (D2) 0.67/0.62; and (D1) 0.66/0.33. The control maternal-reared (MR) group remained with the dam. Fads1 expression was not significantly different between FR and MR groups. Fads2 expression was down-regulated significantly in diets with 1:1 ratio of ARA:DHA, compared to MR. Fads2 AT1 expression was highly correlated to Fads2 expression. Fads3 AT7 was the only Fads3 transcript sensitive to dietary LC-PUFA intake and was up-regulated in the formula diets with lowest ARA and DHA contents compared to MR. Thus, the present study provides evidence that the proportion of dietary ARA:DHA is a significant determinant of Fads2 expression and LC-PUFA metabolism during the early postnatal period. Further, the data suggest that Fads3 AT7 may have functional significance when dietary supply of ARA and DHA are low during early development. © 2013 Elsevier Ltd. All rights reserved.

Taking the Radio Blinders Off of M83: A Wide Spectrum Analysis of the Historical Point Source Population

NASA Astrophysics Data System (ADS)

Stockdale, Christopher; Keefe, Clayton; Nichols, Michael; Rujevcan, Colton; Blair, William P.; Cowan, John J.; Godfrey, Leith; Miller-Jones, James; Kuntz, K. D.; Long, Knox S.; Maddox, Larry A.; Plucinsky, Paul P.; Pritchard, Tyler A.; Soria, Roberto; Whitmore, Bradley C.; Winkler, P. Frank

2015-01-01

We present low frequency observations of the grand design spiral galaxy, M83, using the C and L bands of the Karl G. Jansky Very Large Array (VLA). With recent optical (HST) and X-ray (Chandra) observations and utilizing the newly expanded bandwidth of the VLA, we are exploring the radio spectral properties of the historical radio point sources in M83. These observations allow us to probe the evolution of supernova remnants (SNRs) and to find previously undiscovered SNRs. These observations represent the fourth epoch of deep VLA observations of M83. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities.

Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

PubMed Central

2014-01-01

Background Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma associated with poor prognosis. Implementation of high-dose cytarabine (araC) into induction therapy became standard-of-care for all newly diagnosed younger MCL patients. However, many patients relapse even after araC-based regimen. Molecular mechanisms responsible for araC resistance in MCL are unknown and optimal treatment strategy for relapsed/refractory MCL patients remains elusive. Methods Five araC-resistant (R) clones were derived by long-term culture of five MCL cell lines (CTRL) with increasing doses of araC up to 50 microM. Illumina BeadChip and 2-DE proteomic analysis were used to identify gene and protein expression changes associated with araC resistance in MCL. In vitro cytotoxicity assays and experimental therapy of MCL xenografts in immunodeficient mice were used to analyze their relative responsiveness to a set of clinically used anti-MCL drugs. Primary MCL samples were obtained from patients at diagnosis and after failure of araC-based therapies. Results Marked downregulation of deoxycytidine-kinase (DCK) mRNA and protein expression was identified as the single most important molecular event associated with araC-resistance in all tested MCL cell lines and in 50% primary MCL samples. All R clones were highly (20-1000x) cross-resistant to all tested nucleoside analogs including gemcitabine, fludarabine and cladribine. In vitro sensitivity of R clones to other classes of clinically used anti-MCL agents including genotoxic drugs (cisplatin, doxorubicin, bendamustine) and targeted agents (bortezomib, temsirolimus, rituximab) remained unaffected, or was even increased (ibrutinib). Experimental therapy of immunodeficient mice confirmed the anticipated loss of anti-tumor activity (as determined by overall survival) of the nucleoside analogs gemcitabine and fludarabine in mice transplanted with R clone compared to mice transplanted with CTRL cells, while the anti-tumor activity of cisplatin, temsirolimus, bortezomib, bendamustine, cyclophosphamide and rituximab remained comparable between the two cohorts. Conclusions Acquired resistance of MCL cells to araC is associated with downregulation of DCK, enzyme of the nucleotide salvage pathway responsible for the first phosphorylation (=activation) of most nucleoside analogs used in anti-cancer therapy. The data suggest that nucleoside analogs should not be used in the therapy of MCL patients, who relapse after failure of araC-based therapies. PMID:24972933

Search for Efficient Foreground Subtraction Method in 21cm Cosmology

NASA Astrophysics Data System (ADS)

Datta, Abhirup; Choudhury, Madhurima; Chakraborty, Arnab

2017-06-01

Observations of the HI 21 cm transition line promises to be an important probe into the cosmic Dark Ages and Epoch of Reionization. Detection of this redshifted 21 cm signal is one of the key science goal for several upcoming and future low frequency radio telescopes like Hydrogen Epoch of Reionization Array (HERA), Square Kilometer Array (SKA) and Dark Ages Radio Explorer (DARE). One of the challenges for the detection of this signal is the accuracy of the foreground source removal. Several novel techniques have been explored already to remove bright foregrounds from both interferometric as well as total power experiments. Here, we present preliminary results from our investigation on application of Artificial Neural Networks to detect faint 21cm global signal amidst the sea of bright galactic foreground.

The NRAO Observing for University Classes Program

NASA Astrophysics Data System (ADS)

Cannon, John M.; Van Moorsel, Gustaaf A.

2017-01-01

The NRAO "Observing for University Classes" program is a tremendous resource for instructors of courses in observational astronomy. As a service to the astronomical and educational communities, the NRAO offers small amounts of observing time on the Very Large Array (VLA) and the Very Long Baseline Array to such instructors. The data can be used by students and faculty to demonstrate radio astronomy theory with modern data products. Further, the results may lead to publication; this is a unique opportunity for faculty members to integrate research into the classroom. Previous experience with NRAO facilities is required for instructors; individuals without radio astronomy experience can take advantage of other NRAO educational opportunities (e.g., the Synthesis Imaging Workshop) prior to using the program. No previous experience with radio astronomy data is required for students; this is the primary target audience of the program. To demonstrate concept, this poster describes three different VLA observing programs that have been completed using the "Observing for University Classes" resource at Macalester College; undergraduate students have published the results of all three of these programs. Other recent "Observing for University Classes" programs are also described.

Experimental Array for Generating Dual Circularly-Polarized Dual-Mode OAM Radio Beams.

PubMed

Bai, Xu-Dong; Liang, Xian-Ling; Sun, Yun-Tao; Hu, Peng-Cheng; Yao, Yu; Wang, Kun; Geng, Jun-Ping; Jin, Rong-Hong

2017-01-10

Recently, vortex beam carrying orbital angular momentum (OAM) for radio communications has attracted much attention for its potential of transmitting multiple signals simultaneously at the same frequency, which can be used to increase the channel capacity. However, most of the methods for getting multi-mode OAM radio beams are of complicated structure and very high cost. This paper provides an effective solution of generating dual circularly-polarized (CP) dual-mode OAM beams. The antenna consists of four dual-CP elements which are sequentially rotated 90 degrees in the clockwise direction. Different from all previous published research relating to OAM generation by phased arrays, the four elements are fed with the same phase for both left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). The dual-mode operation for OAM is achieved through the opposite phase differences generated for LHCP and RHCP, when the dual-CP elements are sequentially rotated in the clockwise direction. The measured results coincide well with the simulated ones, which verified the effectiveness of the proposed design.

The Beaming Structures of Jupiter’s Decametric Common S-bursts Observed from the LWA1, NDA, and URAN2 Radio Telescopes

NASA Astrophysics Data System (ADS)

Imai, Masafumi; Lecacheux, Alain; Clarke, Tracy E.; Higgins, Charles A.; Panchenko, Mykhaylo; Dowell, Jayce; Imai, Kazumasa; Brazhenko, Anatolii I.; Frantsuzenko, Anatolii V.; Konovalenko, Alexandr A.

2016-08-01

On 2015 February 21, simultaneous observations of Jupiter's decametric radio emission between 10 and 33 MHz were carried out using three powerful low-frequency radio telescopes: the Long Wavelength Array Station One in the USA, the Nançay Decameter Array in France, and the URAN2 telescope in Ukraine. We measured the lag times of short-bursts (S-bursts) for 105 minutes of data over effective baselines of up to 8460 km by using cross-correlation analysis of the spectrograms from each instrument. Of particular interest is the measurement of the beaming thickness of S-bursts, testing if either flashlight- or beacon-like beaming is emanating from Jupiter. We find that the lag times for all pairs drift slightly as time elapses, in agreement with expectations from the flashlight-like beaming model. This leads to a new constraint of the minimum beaming thickness of 2.″66. Also, we find that most of the analyzed data abound with S-bursts, whose occurrence probability peaks at 17-18 MHz.

SETI Observations of Exoplanets with the Allen Telescope Array

NASA Astrophysics Data System (ADS)

Harp, G. R.; Richards, Jon; Tarter, Jill C.; Dreher, John; Jordan, Jane; Shostak, Seth; Smolek, Ken; Kilsdonk, Tom; Wilcox, Bethany R.; Wimberly, M. K. R.; Ross, John; Barott, W. C.; Ackermann, R. F.; Blair, Samantha

2016-12-01

We report radio SETI observations on a large number of known exoplanets and other nearby star systems using the Allen Telescope Array (ATA). Observations were made over about 19000 hr from 2009 May to 2015 December. This search focused on narrowband radio signals from a set totaling 9293 stars, including 2015 exoplanet stars and Kepler objects of interest and an additional 65 whose planets may be close to their habitable zones. The ATA observations were made using multiple synthesized beams and an anticoincidence filter to help identify terrestrial radio interference. Stars were observed over frequencies from 1 to 9 GHz in multiple bands that avoid strong terrestrial communication frequencies. Data were processed in near-real time for narrowband (0.7-100 Hz) continuous and pulsed signals with transmitter/receiver relative accelerations from -0.3 to 0.3 m s-2. A total of 1.9 × 108 unique signals requiring immediate follow-up were detected in observations covering more than 8 × 106 star-MHz. We detected no persistent signals from extraterrestrial technology exceeding our frequency-dependent sensitivity threshold of 180-310 × 10-26 W m-2.

Detection of a Double Relic in the Torpedo Cluster: SPT-CL J0245-5302

NASA Astrophysics Data System (ADS)

Zheng, Q.; Johnston-Hollitt, M.; Duchesne, S. W.; Li, W. T.

2018-06-01

The Torpedo cluster, SPT-CL J0245-5302 (S0295) is a massive, merging cluster at a redshift of z = 0.300, which exhibits a strikingly similar morphology to the Bullet cluster 1E 0657-55.8 (z = 0.296), including a classic bow shock in the cluster's intra-cluster medium revealed by Chandra X-ray observations. We present Australia Telescope Compact Array data centred at 2.1 GHz and Murchison Widefield Array data at frequencies between 72 MHz and 231 MHz which we use to study the properties of the cluster. We characterise a number of discrete and diffuse radio sources in the cluster, including the detection of two previously unknown radio relics on the cluster periphery. The average spectral index of the diffuse emission between 70 MHz and 3.1 GHz is α =-1.63_{-0.10}^{+0.10} and a radio-derived Mach number for the shock in the west of the cluster is calculated as M = 2.04. The Torpedo cluster is thus a double relic system at moderate redshift.

A Multi-wavelength Study of the Turbulent Central Engine of the Low-mass AGN Hosted by NGC 404

NASA Astrophysics Data System (ADS)

Nyland, Kristina; Davis, Timothy A.; Nguyen, Dieu D.; Seth, Anil; Wrobel, Joan M.; Kamble, Atish; Lacy, Mark; Alatalo, Katherine; Karovska, Margarita; Maksym, W. Peter; Mukherjee, Dipanjan; Young, Lisa M.

2017-08-01

The nearby dwarf galaxy NGC 404 harbors a low-luminosity active galactic nucleus powered by the lowest-mass (<150,000 M ⊙) central massive black hole (MBH), with a dynamical mass constraint, currently known, thus providing a rare low-redshift analog to the MBH “seeds” that formed in the early universe. Here, we present new imaging of the nucleus of NGC 404 at 12-18 GHz with the Karl G. Jansky Very Large Array (VLA) and observations of the CO(2-1) line with the Atacama Large Millimeter/Submillimeter Array (ALMA). For the first time, we have successfully resolved the nuclear radio emission, revealing a centrally peaked, extended source spanning 17 pc. Combined with previous VLA observations, our new data place a tight constraint on the radio spectral index and indicate an optically thin synchrotron origin for the emission. The peak of the resolved radio source coincides with the dynamical center of NGC 404, the center of a rotating disk of molecular gas, and the position of a compact, hard X-ray source. We also present evidence for shocks in the NGC 404 nucleus from archival narrowband HST imaging, Chandra X-ray data, and Spitzer mid-infrared spectroscopy, and discuss possible origins for the shock excitation. Given the morphology, location, and steep spectral index of the resolved radio source, as well as constraints on nuclear star formation from the ALMA CO(2-1) data, we find the most likely scenario for the origin of the radio source in the center of NGC 404 to be a radio outflow associated with a confined jet driven by the active nucleus.

What Are “X-shaped” Radio Sources Telling Us? II. Properties of a Sample of 87

NASA Astrophysics Data System (ADS)

Saripalli, Lakshmi; Roberts, David H.

2018-01-01

In an earlier paper, we presented Jansky Very Large Array multi-frequency, multi-array continuum imaging of a unique sample of low-axial ratio radio galaxies. In this paper, the second in the series, we examine the images to learn the phenomenology of how the off-axis emission relates to the main radio source. Inversion-symmetric offset emission appears to be bimodal and to originate from one of two strategic locations: outer ends of radio lobes (outer-deviation) or from inner ends (inner-deviation). The latter sources are almost always associated with edge-brightened sources. With S- and Z-shaped sources being a subset of outer-deviation sources, this class lends itself naturally to explanations involving black hole axis precession. Our data allow us to present a plausible model for the more enigmatic inner-deviation sources with impressive wings; as for outer-deviation sources these too require black hole axis shifts, although they also require plasma backflows into relic channels. Evolution in morphology over time relates the variety in structures in inner-deviation sources including XRGs. With features such as non-collinearities, central inner-S “spine,” corresponding lobe emission peaks, double and protruding hotspots not uncommon, black hole axis precession, drifts, or flips could be active in a significant fraction of radio sources with prominent off-axis emission. At least 4% of radio galaxies appear to undergo black hole axis rotation. Quasars offer a key signature for recognizing rotating axes. With a rich haul of sources that have likely undergone axis rotation, our work shows the usefulness of low-axial ratio sources in pursuing searches for binary supermassive black holes.

Adaptive reconfigurable V-BLAST type equalizer for cognitive MIMO-OFDM radios

NASA Astrophysics Data System (ADS)

Ozden, Mehmet Tahir

2015-12-01

An adaptive channel shortening equalizer design for multiple input multiple output-orthogonal frequency division multiplexing (MIMO-OFDM) radio receivers is considered in this presentation. The proposed receiver has desirable features for cognitive and software defined radio implementations. It consists of two sections: MIMO decision feedback equalizer (MIMO-DFE) and adaptive multiple Viterbi detection. In MIMO-DFE section, a complete modified Gram-Schmidt orthogonalization of multichannel input data is accomplished using sequential processing multichannel Givens lattice stages, so that a Vertical Bell Laboratories Layered Space Time (V-BLAST) type MIMO-DFE is realized at the front-end section of the channel shortening equalizer. Matrix operations, a major bottleneck for receiver operations, are accordingly avoided, and only scalar operations are used. A highly modular and regular radio receiver architecture that has a suitable structure for digital signal processing (DSP) chip and field programable gate array (FPGA) implementations, which are important for software defined radio realizations, is achieved. The MIMO-DFE section of the proposed receiver can also be reconfigured for spectrum sensing and positioning functions, which are important tasks for cognitive radio applications. In connection with adaptive multiple Viterbi detection section, a systolic array implementation for each channel is performed so that a receiver architecture with high computational concurrency is attained. The total computational complexity is given in terms of equalizer and desired response filter lengths, alphabet size, and number of antennas. The performance of the proposed receiver is presented for two-channel case by means of mean squared error (MSE) and probability of error evaluations, which are conducted for time-invariant and time-variant channel conditions, orthogonal and nonorthogonal transmissions, and two different modulation schemes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cseh, David; Corbel, Stephane; Kaaret, Philip

We present new radio, optical, and X-ray observations of three ultraluminous X-ray sources (ULXs) that are associated with large-scale nebulae. We report the discovery of a radio nebula associated with the ULX IC 342 X-1 using the Very Large Array (VLA). Complementary VLA observations of the nebula around Holmberg II X-1, and high-frequency Australia Telescope Compact Array and Very Large Telescope spectroscopic observations of NGC 5408 X-1 are also presented. We study the morphology, ionization processes, and the energetics of the optical/radio nebulae of IC 342 X-1, Holmberg II X-1, and NGC 5408 X-1. The energetics of the optical nebulamore » of IC 342 X-1 is discussed in the framework of standard bubble theory. The total energy content of the optical nebula is 6 Multiplication-Sign 10{sup 52} erg. The minimum energy needed to supply the associated radio nebula is 9.2 Multiplication-Sign 10{sup 50} erg. In addition, we detected an unresolved radio source at the location of IC 342 X-1 at the VLA scales. However, our Very Long Baseline Interferometry (VLBI) observations using the European VLBI Network likely rule out the presence of any compact radio source at milliarcsecond (mas) scales. Using a simultaneous Swift X-ray Telescope measurement, we estimate an upper limit on the mass of the black hole in IC 342 X-1 using the 'fundamental plane' of accreting black holes and obtain M{sub BH} {<=} (1.0 {+-} 0.3) Multiplication-Sign 10{sup 3} M{sub Sun }. Arguing that the nebula of IC 342 X-1 is possibly inflated by a jet, we estimate accretion rates and efficiencies for the jet of IC 342 X-1 and compare with sources like S26, SS433, and IC 10 X-1.« less

A Multi-wavelength Study of the Turbulent Central Engine of the Low-mass AGN Hosted by NGC 404

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nyland, Kristina; Lacy, Mark; Davis, Timothy A.

The nearby dwarf galaxy NGC 404 harbors a low-luminosity active galactic nucleus powered by the lowest-mass (<150,000 M {sub ⊙}) central massive black hole (MBH), with a dynamical mass constraint, currently known, thus providing a rare low-redshift analog to the MBH “seeds” that formed in the early universe. Here, we present new imaging of the nucleus of NGC 404 at 12–18 GHz with the Karl G. Jansky Very Large Array (VLA) and observations of the CO(2–1) line with the Atacama Large Millimeter/Submillimeter Array (ALMA). For the first time, we have successfully resolved the nuclear radio emission, revealing a centrally peaked,more » extended source spanning 17 pc. Combined with previous VLA observations, our new data place a tight constraint on the radio spectral index and indicate an optically thin synchrotron origin for the emission. The peak of the resolved radio source coincides with the dynamical center of NGC 404, the center of a rotating disk of molecular gas, and the position of a compact, hard X-ray source. We also present evidence for shocks in the NGC 404 nucleus from archival narrowband HST imaging, Chandra X-ray data, and Spitzer mid-infrared spectroscopy, and discuss possible origins for the shock excitation. Given the morphology, location, and steep spectral index of the resolved radio source, as well as constraints on nuclear star formation from the ALMA CO(2–1) data, we find the most likely scenario for the origin of the radio source in the center of NGC 404 to be a radio outflow associated with a confined jet driven by the active nucleus.« less

Radio Detection of the Fermi-LAT Blind Search Millisecond Pulsar J1311-3430

NASA Astrophysics Data System (ADS)

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.; Guillemot, L.; Johnston, S.; Keith, M.; Kerr, M.; Kramer, M.; Pletsch, H. J.; Saz Parkinson, P. M.; Wood, K. S.

2013-01-01

We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (LAT) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of ~4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nançay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Large Array. These detections demonstrate that PSR J1311-3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm-3 provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of LAT-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.

Radio and X-Ray Observations of the 1998 Outburst of the Recurrent X-Ray Transient 4U 1630-47

NASA Astrophysics Data System (ADS)

Hjellming, R. M.; Rupen, M. P.; Mioduszewski, A. J.; Kuulkers, E.; McCollough, M.; Harmon, B. A.; Buxton, M.; Sood, R.; Tzioumis, A.; Rayner, D.; Dieters, S.; Durouchoux, P.

1999-03-01

We report radio (NRAO VLA and Australia Telescope Compact Array), soft X-ray (Rossi X-Ray Timing Explorer ASM), and hard X-ray (Compton Gamma Ray Observatory BATSE) observations of a 1998 outburst in the recurring X-ray transient 4U 1630-47, where radio emission was detected for the first time. The radio observations identify the position of 4U 1630-47 to within 1". Because the radio emission is optically thin with a spectral index of ~-0.8 during the rise, peak, and decay of the initial radio event, the emission is probably coming from an optically thin radio jet ejected over a period of time. The 20-100 keV emission first appeared 1998 January 28 (MJD 50841), the 2-12 keV emission first appeared 1998 February 3 (MJD 50847), and the first radio emission was detected 1998 February 12.6 (MJD 50856.6). The rise of the radio emission probably began about 1998 February 7 (MJD 50851) when the X-rays were in a very hard fluctuating-hardness state, just before changing to a softer, more stable hardness state.

Three-layered radio frequency coil arrangement for sodium MRI of the human brain at 9.4 Tesla.

PubMed

Shajan, G; Mirkes, Christian; Buckenmaier, Kai; Hoffmann, Jens; Pohmann, Rolf; Scheffler, Klaus

2016-02-01

A multinuclei imaging setup with the capability to acquire both sodium ((23) Na) and proton ((1) H) signals at 9.4 Tesla is presented. The main objective was to optimize coil performance at the (23) Na frequency while still having the ability to acquire satisfactory (1) H images. The setup consisted of a combination of three radio frequency (RF) coils arranged in three layers: the innermost layer was a 27-channel (23) Na receive helmet which was surrounded by a four-channel (23) Na transceiver array. The outer layer consisted of a four-channel (1) H dipole array for B0 shimming and anatomical localization. Transmit and receive performance of the (23) Na arrays was compared to a single-tuned (23) Na birdcage resonator. While the transmit efficiency of the (23) Na transceiver array was comparable to the birdcage, the (23) Na receive array provided substantial signal-to-noise ratio (SNR) gain near the surface and comparable SNR in the center. The utility of this customized setup was demonstrated by (23) Na images of excellent quality. High SNR, efficient transmit excitation and B0 shimming capability can be achieved for (23) Na MRI at 9.4T using novel coil combination. This RF configuration is easily adaptable to other multinuclei applications at ultra high field (≥ 7T). © 2015 Wiley Periodicals, Inc.

Exploring the performance of large-N radio astronomical arrays

NASA Astrophysics Data System (ADS)

Lonsdale, Colin J.; Doeleman, Sheperd S.; Cappallo, Roger J.; Hewitt, Jacqueline N.; Whitney, Alan R.

2000-07-01

New radio telescope arrays are currently being contemplated which may be built using hundreds, or even thousands, of relatively small antennas. These include the One Hectare Telescope of the SETI Institute and UC Berkeley, the LOFAR telescope planned for the New Mexico desert surrounding the VLA, and possibly the ambitious international Square Kilometer Array (SKA) project. Recent and continuing advances in signal transmission and processing technology make it realistic to consider full cross-correlation of signals from such a large number of antennas, permitting the synthesis of an aperture with much greater fidelity than in the past. In principle, many advantages in instrumental performance are gained by this 'large-N' approach to the design, most of which require the development of new algorithms. Because new instruments of this type are expected to outstrip the performance of current instruments by wide margins, much of their scientific productivity is likely to come from the study of objects which are currently unknown. For this reason, instrumental flexibility is of special importance in design studies. A research effort has begun at Haystack Observatory to explore large-N performance benefits, and to determine what array design properties and data reduction algorithms are required to achieve them. The approach to these problems, involving a sophisticated data simulator, algorithm development, and exploration of array configuration parameter space, will be described, and progress to date will be summarized.

Performance of a Highly Sensitive, 19-element, Dual-polarization, Cryogenic L-band Phased-array Feed on the Green Bank Telescope

NASA Astrophysics Data System (ADS)

Roshi, D. Anish; Shillue, W.; Simon, B.; Warnick, K. F.; Jeffs, B.; Pisano, D. J.; Prestage, R.; White, S.; Fisher, J. R.; Morgan, M.; Black, R.; Burnett, M.; Diao, J.; Ruzindana, M.; van Tonder, V.; Hawkins, L.; Marganian, P.; Chamberlin, T.; Ray, J.; Pingel, N. M.; Rajwade, K.; Lorimer, D. R.; Rane, A.; Castro, J.; Groves, W.; Jensen, L.; Nelson, J. D.; Boyd, T.; Beasley, A. J.

2018-05-01

A new 1.4 GHz, 19-element, dual-polarization, cryogenic phased-array feed (PAF) radio astronomy receiver has been developed for the Robert C. Byrd Green Bank Telescope (GBT) as part of the Focal L-band Array for the GBT (FLAG) project. Commissioning observations of calibrator radio sources show that this receiver has the lowest reported beam-formed system temperature (T sys) normalized by aperture efficiency (η) of any phased-array receiver to date. The measured T sys/η is 25.4 ± 2.5 K near 1350 MHz for the boresight beam, which is comparable to the performance of the current 1.4 GHz cryogenic single-feed receiver on the GBT. The degradation in T sys/η at ∼4‧ (required for Nyquist sampling) and ∼8‧ offsets from the boresight is, respectively, ∼1% and ∼20% of the boresight value. The survey speed of the PAF with seven formed beams is larger by a factor between 2.1 and 7 compared to a single-beam system, depending on the observing application. The measured performance, both in frequency and offset from the boresight, qualitatively agrees with predictions from a rigorous electromagnetic model of the PAF. The astronomical utility of the receiver is demonstrated by observations of the pulsar B0329+54 and an extended H II region, the Rosette Nebula. The enhanced survey speed with the new PAF receiver will enable the GBT to carry out exciting new science, such as more efficient observations of diffuse, extended neutral hydrogen emission from galactic inflows and searches for fast radio bursts.

LIGHTWEIGHT INTEGRATED SOLAR ARRAY AND TRANSCEIVER

NASA Image and Video Library

2016-09-23

JOHN CARR, CO-PRINCIPAL INVESTIGATOR FOR NASA'S LIGHTWEIGHT INTEGRATED SOLAR ARRAY AND TRANSCEIVER PROJECT, KNEELS TO SHOW HOW ONE OF THE THIN-FILM SIDES OR "PETALS" IN WHICH PHOTO-VOLTAIC CELLS ARE EMBEDDED, IS FOLDED AND STOWED BEFORE LAUNCH. LOOKING ON DURING A DEMONSTRATION AFTER TESTING AT NEXOLVE, ARE LES JOHNSON, LEFT, ALSO CO-PRINCIPAL INVESTIGATOR, AND DARREN BOYD, RIGHT, THE RADIO FREQUENCY LEAD FOR THE PROJECT.

Phase Synchronization for the Mid-Frequency Square Kilometre Array Telescope

NASA Astrophysics Data System (ADS)

Schediwy, Sascha; Gozzard, David; Stobie, Simon; Gravestock, Charles; Whitaker, Richard; Alachkar, Bassem; Malan, Sias; Boven, Paul; Grainge, Keith

2018-01-01

The Square Kilometre Array (SKA) project is an international effort to build the world’s most sensitive radio telescope operating in the 50 MHz to 14 GHz frequency range. Construction of the SKA has been divided into phases, with the first phase (SKA1) accounting for the first 10% of the telescope's receiving capacity. During SKA1, a low-frequency aperture array comprising over a hundred thousand individual dipole antenna elements will be constructed in Western Australia (SKA1-low), while an array of 197 parabolic-dish antennas, incorporating the 64 dishes of MeerKAT, will be constructed in South Africa (SKA1-mid).Radio telescope arrays such as the SKA require phase-coherent reference signals to be transmitted to each antenna site in the array. In the case of the SKA1-mid, these reference signals will be generated at a central site and transmitted to the antenna sites via fiber-optic cables up to 175 km in length. Environmental perturbations affect the optical path length of the fiber and act to degrade the phase stability of the reference signals received at the antennas, which has the ultimate effect of reducing the fidelity and dynamic range of the data.Since 2011, researchers at the University of Western Australia (UWA) have led the development of an actively-stabilized phase-synchronization system designed specifically to meet the scientific needs and technical challenges of the SKA telescope. Recently this system has been select as the official phase synchronization system for the SKA1-mid telescope. The system is an evolution of Atacama Large Millimeter Array’s distributed ‘photonic local oscillator system’, incorporating key advances made by the international frequency metrology community over the last decade, as well as novel innovations developed by UWA researchers.In this presentation I will describe the technical details of the system; outline how the system's performance was tested using metrology techniques in a laboratory setting, on 186 km of overhead fibre at the South African SKA site, and verified using existing astronomical radio interferometers; and how the system can enhance the astronomical performance of the SKA1-mid telescope.

Citizen Science Opportunity With the NASA Heliophysics Education Consortium (HEC)-Radio JOVE Project

NASA Astrophysics Data System (ADS)

Fung, S. F.; Higgins, C.; Thieman, J.; Garcia, L. N.; Young, C. A.

2016-12-01

The Radio JOVE project has long been a hands-on inquiry-based educational project that allows students, teachers and the general public to learn and practice radio astronomy by building their own radio antenna and receiver system from an inexpensive kit that operates at 20.1 MHz and/or using remote radio telescopes through the Internet. Radio JOVE participants observe and analyze natural radio emissions from Jupiter and the Sun. Within the last few years, several Radio JOVE amateurs have upgraded their equipment to make semi-professional spectrographic observations in the frequency band of 15-30 MHz. Due to the widely distributed Radio JOVE observing stations across the US, the Radio JOVE observations can uniquely augment observations by professional telescopes, such as the Long Wavelength Array (LWA) . The Radio JOVE project has recently partnered with the NASA Heliophysics Education Consortium (HEC) to work with students and interested amateur radio astronomers to establish additional spectrograph and single-frequency Radio JOVE stations. These additional Radio JOVE stations will help build a larger amateur radio science network and increase the spatial coverage of long-wavelength radio observations across the US. Our presentation will describe the Radio JOVE project within the context of the HEC. We will discuss the potential for citizen scientists to make and use Radio JOVE observations to study solar radio bursts (particularly during the upcoming solar eclipse in August 2017) and Jovian radio emissions. Radio JOVE observations will also be used to study ionospheric radio scintillation, promoting appreciation and understanding of this important space weather effect.

Radio constraints on the mass-loss rate of the Type Ia SN 2018gv

NASA Astrophysics Data System (ADS)

Ryder, S. D.; Lundqvist, P.; Perez-Torres, M. A.; Kundu, E.; Kool, E. C.; Bjornsson, C.-I.; Fransson, C.

2018-01-01

The young Type Ia SN 2018gv (ATel #11175, #11177) in the galaxy NGC 2525 has been observed with the Australia Telescope Compact Array (ATCA) at 5.5 and 9.0 GHz on 2018 Jan 18.6 UT. No radio emission was detected at the reported location, to a 3-sigma upper limit of 120 microJy/beam (5.5 GHz) and 30 microJy/beam (9.0 GHz).

Radio Observations of Nova Muscae 2018 and Nova Carinae 2018 (ASASSN-18fv)

NASA Astrophysics Data System (ADS)

Ryder, S. D.; Kool, E. C.; Chomiuk, L.

2018-04-01

The two optically-bright Galactic novae in Musca (CBET #4473, ATel #11183, #11201, #11212, #11296) and in Carina (ATel #11454, #11456, #11457, #11460, #11468) were observed at radio wavelengths using the Australia Telescope Compact Array (ATCA) on 2018 Apr 3.3 UT. Nova Muscae 2018 has faded by a factor of 3 at 9.0 and 5.5 GHz since peaking at > 30 mJy/bm in mid-March.

Radio Jove: Jupiter Radio Astronomy for Citizens

NASA Astrophysics Data System (ADS)

Higgins, Charles; Thieman, J. R.; Flagg, R.; Reyes, F. J.; Sky, J.; Greenman, W.; Brown, J.; Typinski, D.; Ashcraft, T.; Mount, A.

2014-01-01

Radio JOVE is a hands-on educational activity that brings the radio sounds of the Sun, Jupiter, the Milky Way Galaxy, and terrestrial radio noise to students, teachers, and the general public. Participants may build a simple radio telescope kit, make scientific observations, and interact with professional radio observatories in real-time over the Internet. Our website (http://radiojove.gsfc.nasa.gov) includes science information, construction manuals, observing guides, and education resources for teachers and students. Radio Jove is continually expanding its participants with over 1800 kits sold to more than 70 countries worldwide. Recently some of our most dedicated observers have upgraded their Radio Jove antennas to semi-professional observatories. We have spectrographs and wide band antennas, some with 8 MHz bandwidth and some with dual polarization capabilities. In an effort to add to the science literature, these observers are coordinating their efforts to pursue some basic questions about Jupiter’s radio emissions (radio source locations, spectral structure, long term changes, etc.). We can compare signal and ionosphere variations using the many Radio Jove observers at different locations. Observers are also working with members of the Long Wavelength Array Station 1 (LWA1) radio telescope to coordinate observations of Jupiter; Radio Jove is planning to make coordinated observations while the Juno Mission is active beginning in 2015. The Radio Jove program is overviewed, its hardware and software are highlighted, recent sample observations are shown, and we demonstrate that we are capable of real citizen science.

Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy.

PubMed

Anzengruber, Julia; Bublin, Merima; Bönisch, Eva; Janesch, Bettina; Tscheppe, Angelika; Braun, Matthias L; Varga, Eva-Maria; Hafner, Christine; Breiteneder, Heimo; Schäffer, Christina

2017-05-01

Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most potent peanut allergen, Ara h 2, as a candidate vaccine. Based on the adjuvant capability of bacterial surface (S-) layers, a fusion protein of the S-layer protein SlpB from Lactobacillus buchneri CD034 and the Ara h 2-derived peptide AH3a42 was produced. This peptide comprised immunodominant B-cell epitopes as well as one T cell epitope. The fusion protein SlpB-AH3a42 was expressed in E. coli, purified, and tested for its IgE binding capacity as well as for its ability to activate sensitized rat basophil leukemia (RBL) cells. The capacity of Ara h 2-specific IgG rabbit-antibodies raised against SlpB-AH3a42 or Ara h 2 to inhibit IgE-binding was determined by ELISA inhibition assays using sera of peanut allergic patients sensitized to Ara h 2. IgE specific to the SlpB-AH3a42 fusion protein was detected in 69% (25 of 36) of the sera. Despite the recognition by IgE, the SlpB-AH3a42 fusion protein was unable to induce β-hexosaminidase release from sensitized RBL cells at concentrations up to 100ng per ml. The inhibition of IgE-binding to the natural allergen observed after pre-incubation of the 20 sera with rabbit anti-SlpB-AH3a42 IgG was more than 30% for four sera, more than 20% for eight sera, and below 10% for eight sera. In comparison, anti-Ara h 2 rabbit IgG antibodies inhibited binding to Ara h 2 by 48% ±13.5%. Our data provide evidence for the feasibility of this novel approach towards the development of a peanut allergen peptide-based carrier-bound vaccine. Our experiments further indicate that more than one allergen-peptide will be needed to induce a broader protection of patients allergic to Ara h 2. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

FABP-1 gene ablation impacts brain endocannabinoid system in male mice.

PubMed

Martin, Gregory G; Chung, Sarah; Landrock, Danilo; Landrock, Kerstin K; Huang, Huan; Dangott, Lawrence J; Peng, Xiaoxue; Kaczocha, Martin; Seeger, Drew R; Murphy, Eric J; Golovko, Mikhail Y; Kier, Ann B; Schroeder, Friedhelm

2016-08-01

Liver fatty acid-binding protein (FABP1, L-FABP) has high affinity for and enhances uptake of arachidonic acid (ARA, C20:4, n-6) which, when esterified to phospholipids, is the requisite precursor for synthesis of endocannabinoids (EC) such as arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG). The brain derives most of its ARA from plasma, taking up ARA and transporting it intracellularly via cytosolic fatty acid-binding proteins (FABPs 3,5, and 7) localized within the brain. In contrast, the much more prevalent cytosolic FABP1 is not detectable in the brain but is instead highly expressed in the liver. Therefore, the possibility that FABP1 outside the central nervous system may regulate brain AEA and 2-AG was examined in wild-type (WT) and FABP1 null (LKO) male mice. LKO increased brain levels of AA-containing EC (AEA, 2-AG), correlating with increased free and total ARA in brain and serum. LKO also increased brain levels of non-ARA that contain potentiating endocannabinoids (EC*) such as oleoyl ethanolamide (OEA), PEA, 2-OG, and 2-PG. Concomitantly, LKO decreased serum total ARA-containing EC, but not non-ARA endocannabinoids. LKO did not elicit these changes in the brain EC and EC* as a result of compensatory up-regulation of brain protein levels of enzymes in EC synthesis (NAPEPLD, DAGLα) or cytosolic EC chaperone proteins (FABPs 3, 5, 7, SCP-2, HSP70), or cannabinoid receptors (CB1, TRVP1). These data show for the first time that the non-CNS fatty acid-binding protein FABP1 markedly affected brain levels of both ARA-containing endocannabinoids (AEA, 2-AG) as well as their non-ARA potentiating endocannabinoids. Fatty acid-binding protein-1 (FABP-1) is not detectable in brain but instead is highly expressed in liver. The possibility that FABP1 outside the central nervous system may regulate brain endocannabinoids arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG) was examined in wild-type (WT) and FABP-1 null (LKO) male mice. LKO increased brain levels of arachidonic acid-containing endocannabinoids (AEA, 2-AG), correlating with increased free and total arachidonic acid in brain and serum. Read the Editorial Highlight for this article on page 371. © 2016 International Society for Neurochemistry.