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Sample records for radiochemotherapie auf die

  1. Wirkungen biogener Amine auf die Erregungs-Sekretions-Kopplung in der Speicheldrüse von Periplaneta americana (L.)

    NASA Astrophysics Data System (ADS)

    Rietdorf, Katja

    2003-07-01

    In der vorliegenden Arbeit habe ich wichtige Teilmechanismen der Erregungs-Sekretionskopplung in der Speicheldrüse der Schabe Periplaneta americana (L.) untersucht. Die Speicheldrüse ist von dopaminergen und serotonergen Fasern innerviert (Baumann et al., 2002). Beide Transmitter stimulieren eine unterschiedliche Reaktion der Drüse: Dopamin (DA) stimuliert die P-Zellen der Acini und die Ausführgangzellen, während Serotonin (5-HT) die P- und C-Zellen der Acini stimuliert, nicht jedoch die Ausführgangzellen. Der Endspeichel ist nach einer DA-Stimulierung proteinfrei. Dagegen enthält er nach einer 5-HT-Stimulierung Proteine, die von den C-Zellen sezerniert werden (Just & Walz, 1996). Im ersten Teil meiner Arbeit habe ich mittels Kapillarelektrophoretischer Analyse (CE-Analyse) die Elektrolytkonzentrationen im Endspeichel untersucht sowie die Raten der Flüssigkeitssekretion gemessen. Damit wollte ich klären, welche Transporter an der Sekretion des Primärspeichels und an dessen Modifikation beteiligt sind. Ausserdem wollte ich die Rolle der transportaktiven Epithelzellen der Ausführgänge für die Modifikation des Primärspeichels untersuchen. Dafür habe ich einen Vergleich der Elektrolytkonzentrationen im DA- und 5-HT-stimulierten Endspeichel durchgeführt. Der Elektrolytgehalt des DA- und 5-HT-stimulierten Endspeichels unterscheidet sich nicht signifikant voneinander. Er ist nach beiden Stimulierungen hypoosmotisch zum verwendeten Ringer. Die Ausführgangzellen werden durch DA stimuliert und modifizieren den Primärspeichel durch eine netto-Ionenreabsorption. Meine Versuche zeigen jedoch, dass auch die während einer 5-HT-Stimulierung der Drüse unstimulierten Ausführgangzellen den Primärspeichel modifizieren. In einer nachfolgenden Versuchsreihe habe ich den Einfluss von Ouabain, einem Hemmstoff der Na+-K+-ATPase, und Bumetanid, einem Hemmstoff des NKCC, auf die Raten der Flüssigkeitssekretion sowie den Elektrolytgehalt des Endspeichels untersucht. Ich

  2. Nanophysik: Wärmeübertrag auf der Nanometerskala

    NASA Astrophysics Data System (ADS)

    Kittel, Achim

    2006-01-01

    Gegen Ende des 19. Jahrhunderts waren die grundlegenden Prozesse des Wärmeaustauschs verstanden. Die Gesetze dienten dann als Grundlage für die Quantenmechanik. Doch gelten diese Gesetze auch auf der Nanometerskala? In den 1970er-Jahren wurde eine Theorie für den Wärmeübertrag im atomaren Bereich entwickelt. Physiker der Universität Oldenburg überprüften deren Vorhersagen und stießen dabei auf signifikante Abweichungen, welche auf einen Zusammenbruch der klassischen, makroskopischen Elektrodynamik hindeuten.

  3. Die Arbeitsunfähigkeit in der Statistik der GKV

    NASA Astrophysics Data System (ADS)

    Busch, Klaus

    Der vorliegende Beitrag gibt anhand der Statistiken des Bundesministeriums für Gesundheit (BMG) einen Überblick über die Arbeitsunfähigkeitsdaten der Gesetzlichen Krankenkassen (GKV). Zunächst werden die Arbeitsunfähigkeitsstatistiken der Krankenkassen und die Erfassung der Arbeitsunfähigkeit erläutert. Hiernach wird auf die Entwicklung der Fehlzeiten auf GKV-Ebene eingegangen. Ebenfalls wird Bezug auf die Unterschiede der Fehlzeiten zwischen den verschiedenen Kassen genommen.

  4. Auf der Suche nach dem Unendlichen.

    NASA Astrophysics Data System (ADS)

    Fraser, G.; Lillestøl, E.; Sellevåg, I.

    This book is a German translation by C. Ascheron and J. Urbahn, of "The search for infinity: solving the mysteries of the universe", published in 1994. Diese Buch beschreibt anschaulich die Meilensteine, die der Mensch seit der Antike auf der Suche nach dem Unendlichen erreicht und hinter sich gelassen hat. Es enthält Kurzbiographien der wichtigsten Forscher, verständlich geschriebene Texte sowie Erläuterungen der entscheidenen Fachtermini.

  5. Die Kometenmission Rosetta

    NASA Astrophysics Data System (ADS)

    Krüger, Harald

    2016-11-01

    Die Rosetta-Mission ist ein Meilenstein in der Erforschung der Kometen und ihrer Entstehung. Eine der größten üerraschungen war die unregelmäßge hantelförmige Gestalt des Zielkometen 67P/Tschurjumow-Gerassimenko. Er besteht wahrscheinlich aus zwei Einzelkörpern, die durch ihre Schwerkraft aneinander gehalten werden. Seine Oberfläche ist sehr rau und zeigt eine sehr vielf ältige Morphologie, die auf eine Vielzahl von ablaufenden Prozessen hindeutet. Der Kometenkern ist vermutlich auf Gr ößnskalen von mehr als etwa 10 bis 100 Metern homogen, Inhomogenitäten auf kleineren Skalen k nnten f r seine Aktivä t verantwortlich sein. Diese ist auf kleine Gebiete konzentriert, und auch Oberflächenveränderungen, die sich innerhalb von einigen Tagen bis wenigen Wochen abspielen, sind lokal. Im Kometenmaterial wurde eine Vielzahl an organischen Substanzen gemessen, die zum Teil als Schlüsselmoleküle für die Synthese der Grundbausteine des Lebens gelten, wie wir es kennen.

  6. Synthese von analogen Filtern auf einer rekonfigurierbaren Hardware-Architektur mittels eines Genetischen Algorithmus

    NASA Astrophysics Data System (ADS)

    Trendelenburg, S.; Becker, J.; Henrici, F.; Manoli, Y.

    2008-05-01

    Rekonfigurierbare Analog-Arrays (FPAAs) sind der Versuch, die Vorteile der aus der digitalen Welt bekannten FPGAs (Flexibilität, Entwurfsgeschwindigkeit) auch für analoge Anwendungen verfügbar zu machen. Aufgrund der Vielfalt der analogen Schaltungstechnik ist die Abbildung von vorgegebenen Schaltungskonzepten auf eine FPAA-Architektur nicht immer einfach lösbar. Diese Arbeit stellt einen neuen Ansatz für die Synthese von Filtern auf einer FPAA-Architektur für zeitkontinuierliche Analogfilter mittels eines Genetischen Algorithmus (GA) vor. Anhand eines Matlab-Modells des FPAA, das eine gute übereinstimmung mit Simulationen des FPAA auf Transistorebene aufweist, wurde gezeigt, dass eine große Vielzahl verschiedener Filterstrukturen auf dieser Architektur dargestellt werden kann. Daraufhin wurde ein Genetischer Algorithmus entwickelt, der es erlaubt, aus einer gegebenen Filterspezifikation Konfigurationsdatensätze zu synthetisieren, die den gewünschten Filter auf die FPAA-Architektur abbilden.

  7. Vollautomatische Einzelzellerkennung auf fluoreszenten Gewebeschnitten humaner Epidermis

    NASA Astrophysics Data System (ADS)

    Pommerencke, Thora; Dickhaus, Hartmut; Grabe, Niels

    Wir stellen hier ein vollautomatisches Verfahren zur Einzelzellerkennung auf fluoreszenten Gewebeschnitten humaner Epidermis vor. Das Ziel dieser Arbeit war es, Expressionsverschiebungen von beispielsweise Zellmembran zu Nucleus detektieren zu können. Diese können bei pathologischen Veränderungen des Gewebes auftreten. Im Vergleich zu anderen existierenden Segmentierungen werden hier die Zellgrenzen in einem kombinierten Ansatz sowohl auf Basis einer Membranfärbung als auch anhand detektierter Zellkerne mittels Watershed ermittelt. Wir konnten zeigen, dass wir mit unserem Verfahren eine Membranfärbung deutlich von einer Zellkernfärbung unterscheiden können. Somit ermöglicht die von uns entwickelte Einzelzellerkennung eine Detektion von Translokationen in der Expression.

  8. [Results of postoperative radiochemotherapy of glioblastoma multiforme].

    PubMed

    Lövey, József; Fedorcsák, Imre; Bajcsay, András; Sipos, László; Mangel, László; Kásler, Miklós; Bagó, Attila

    2013-12-01

    Glioblastoma multiforme has one of the worst prognoses of all cancers. A substantial progression in its treatment has been achieved only eight years ago when a new adjuvant radiochemotherapy regimen containing temozolomid has been introduced to the clinical practice. In this paper we evaluate the treatment results in adjuvant radiochemotherapy of glioblastoma carried out by two neurosurgery and oncology centers in Budapest, Hungary and we compared our results to the data of the reference phase III registration trial of the EORTC/NCIC. We analyzed the data of 210 patients treated for glioblastoma between 2005 and 2013. The primary endpoints of our study were overall survival and side effects. We studied and statistically analyzed the influence of multiple factors on survival. We compared our results with the data of the reference study and other results published in the literature. The median follow-up for the surviving patients in our study was 52 months. The median age of our patients was 58 (18-79) years. Seventy-two women and 138 men have been treated. The median overall survival was 17 (3-96) months, the progression-free survival 11 (3-96) months. The radiochemotherapy phase was completed in 95.2% and the monotherapy phase in 68% of all cases.Univariate analysis showed that age, ECOG status and RPA class had significant influence on survival. In multivariate analysis only RPA class remained statistically significant (RR 1.86, 95% CI 1.14-3.05). The proportion of grade III and worse side effects during the chemoradiation phase was 3.8% and in the monotherapy phase 1.9%. These were hematological side effects only. Serious hematological sequelae occurred nearly exclusively in women. Comparing to the reference study the demographic distribution of the patients was similar in our study but among our patients there were less patients with unfavorable prognosis (ECOG 2 or RPA V), and it resulted in a longer median survival than in the original trial (17 vs. 14

  9. Effect of Cisplatin on Parotid Gland Function in Concomitant Radiochemotherapy

    SciTech Connect

    Hey, Jeremias; Setz, Juergen; Gerlach, Reinhard; Vordermark, Dirk; Gernhardt, Christian R.; Kuhnt, Thomas

    2009-12-01

    Purpose: To determine the influence of concomitant radiochemotherapy with cisplatin on parotid gland tissue complication probability. Methods and Materials: Patients treated with either radiotherapy (n = 61) or concomitant radiochemotherapy with cisplatin (n = 36) for head-and-neck cancer were prospectively evaluated. The dose and volume distributions of the parotid glands were noted in dose-volume histograms. Stimulated salivary flow rates were measured before, during the 2nd and 6th weeks and at 4 weeks and 6 months after the treatment. The data were fit using the normal tissue complication probability model of Lyman. Complication was defined as a reduction of the salivary flow rate to less than 25% of the pretreatment flow rate. Results: The normal tissue complication probability model parameter TD{sub 50} (the dose leading to a complication probability of 50%) was found to be 32.2 Gy at 4 weeks and 32.1 Gy at 6 months for concomitant radiochemotherapy and 41.1 Gy at 4 weeks and 39.6 Gy at 6 months for radiotherapy. The tolerated dose for concomitant radiochemotherapy was at least 7 to 8 Gy lower than for radiotherapy alone at TD{sub 50}. Conclusions: In this study, the concomitant radiochemotherapy tended to cause a higher probability of parotid gland tissue damage. Advanced radiotherapy planning approaches such as intensity-modulated radiotherapy may be partiticularly important for parotid sparing in radiochemotherapy because of cisplatin-related increased radiosensitivity of glands.

  10. Zahlen und Rechenvorgänge auf unterschiedlichen Abstraktionsniveaus

    NASA Astrophysics Data System (ADS)

    Rödler, Klaus

    "Das Verständnis geht langsam vor sich!" Diesen wichtigen Satz hörte ich bei einem Vortrag von Martin Lowsky. Auf die hier behandelte Fragestellung übertragen heißt das: Was eine Zahl ist und wie ich sie im Rechenvorgang einsetzen und interpretieren kann, das erschließt sich erst allmählich. Die Zahl des Rechenanfängers ist nicht dieselbe wie die des kompetenten Rechners und es ist nicht die Zahl des Lehrers oder der Lehrerin. Die Zahlen sind nur auf der Oberfläche der Worte und Zeichen gleich. Im Innern, im Verständnis, sind sie völlig verschieden! Ich glaube, dass die Missachtung dieser Divergenz dazu führt, dass manche Kinder in für den Lehrer und Lehrerin nicht nachvollziehbaren Routinen stecken bleiben, einfachste Informationen nicht wirklich integrieren. Die auf beiden Seiten wachsende Verunsicherung durch die nicht erkannte und daher nicht kommunizierbare Diskrepanz im inneren Zahlkonzept stört den allmählichen Aufbau strukturierter Zahlvorstellungen.

  11. Herausforderungen durch die deutsche Wiedervereinigung

    NASA Astrophysics Data System (ADS)

    Stäglin, Reiner

    Die Wiedervereinigung stellte auch die Statistik vor große Aufgaben. Die als Organ der staatlichen Planung staatsnah orientierte Statistik der DDR musste auf das zur Neutralität und wissenschaftlichen Unabhängigkeit verpflichtete System der Bundesrepublik umgestellt werden. Ebenso verlangten die Universitäten eine Neuorientierung. Die Deutsche Statistische Gesellschaft hat sich vor allem dreier Aufgaben mit großem Engagement, aber auch mit Bedachtsamkeit angenommen: Aufnahme und Integration der Statistiker aus den neuen Bundesländern in die Gesellschaft, Begleitung der Neuausrichtung des Faches Statistik an deren Hochschulen und Sicherung sowie Nutzung von Datenbeständen der ehemaligen DDR.

  12. Kamera-basierte Erkennung von Geschwindigkeitsbeschränkungen auf deutschen Straen

    NASA Astrophysics Data System (ADS)

    Nienhüser, Dennis; Ziegenmeyer, Marco; Gumpp, Thomas; Scholl, Kay-Ulrich; Zöllner, J. Marius; Dillmann, Rüdiger

    An Fahrerassistenzsysteme im industriellen Einsatz werden hohe Anforderungen bezüglich Zuverlässigkeit und Robustheit gestellt. In dieser Arbeit wird die Kombination robuster Verfahren wie der Hough-Transformation und Support-Vektor-Maschinen zu einem Gesamtsystem zur Erkennung von Geschwindigkeitsbeschränkungen beschrieben. Es setzt eine Farbvideokamera als Sensorik ein. Die Evaluation auf Testdaten bestätigt durch die ermittelte hohe Korrektklassifikationsrate bei gleichzeitig geringer Zahl Fehlalarme die Zuverlässigkeit des Systems.

  13. Die Sonne, Stern unserer Erde

    NASA Astrophysics Data System (ADS)

    Lang, Kenneth R.; Ehlers, A.

    Dieses reich bebilderte Buch gibt eine Einführung in die Physik der Sonne und ihre Bedeutung für die Erde. Gestützt auf neueste Forschungsergebnisse aus Radioteleskop- und Satellitenbeobachtungen beschreibt der Autor die gewaltigen atomenergetischen Prozesse der Sonne, ihren geheimnisvollen Neutrinofluß, ihre seismischen Aktivitäten, Magnetfelder und Sonnenflecke, Korona, Sonnenausbrüche und Protuberanzen, den Sonnenwind, und die außerordentlich wichtige und vielfältige Bedeutung des Sonnenlichts, das Leben auf der Erde entstehen läßt und es auch gefährdet. Gut verständlich und in ansprechender Sprache geschrieben ist es ein wunderbares Buch für den Leser populärwissenschaftlicher Literatur, ein wertvolles Geschenk für Studenten der Astronomie und verwandter Disziplinen sowie Amateurastronomen.

  14. Die Evolution der Religiosität

    NASA Astrophysics Data System (ADS)

    Voland, Eckart

    Ein konsequent darwinischer Blick auf den Menschen bedeutet, auch im Denken, Fühlen und Handeln biologische Anpassungsgeschichte zu suchen, denn auch die psychischen und mentalen Eigenheiten des Homo sapiens unterliegen der natürlichen Selektion. Lässt sich die religiöse Lebenspraxis von Menschen daher auch aus einer Fitnessperspektive betrachten?

  15. Untersuchung der Störwirkung von LTE auf SRD Anwendungen bei 868 MHz

    NASA Astrophysics Data System (ADS)

    Welpot, M.; Wunderlich, S.; Gaspard, I.

    2014-11-01

    Moderne Hausautomatisierungssysteme, Alarmanlagen oder auch Funk-Zugangssysteme in Haus und Automobil setzen auf frei nutzbare Frequenzen in ISM/SRD-Bändern. Die rasante Zunahme an privaten und kommerziell genutzten Applikationen im SRD-Band bei 868 MHz und der Ausbau der LTE-Mobilfunknetze im Frequenzbereich unterhalb von 1 GHz ("Digital Dividend") wirft zunehmend die Frage nach der Funkverträglichkeit dieser Systeme untereinander auf. Während die SRD-Funkmodule auf eine geringe Sendeleistung von ~ +14 dBm beschränkt sind (Ralf and Thomas, 2009), beträgt die maximale LTE-Sendeleistung im Uplink nach (ETSI-Norm, 2011) +23 dBm. Zusammen mit der Einführung von LTE im Frequenzbereich unterhalb 1 GHz als DSL-Ersatz vor allem in ländlichen Gebieten, ergibt sich damit als mögliches Störszenario, dass durch die Aussendung des LTE-Endgerätes im Bereich von ca. 850 MHz die SRD-Funkverbindungen bei 868 MHz insbesondere dann gestört werden, wenn die Antennen beider Funksysteme räumlich nahe zueinander angeordnet sind und folglich nur eine geringe zusätzliche Entkopplung der Systeme bieten. In der vorliegenden Arbeit wird das LTE-Störpotential auf SRD-Empfänger praxisnah untersucht.

  16. STF Optimierung von single-bit CT ΣΔ Modulatoren basierend auf skalierten Filterkoeffizienten

    NASA Astrophysics Data System (ADS)

    Widemann, C.; Zorn, C.; Brückner, T.; Ortmanns, M.; Mathis, W.

    2012-09-01

    Die vorliegende Arbeit beschäftigt sich mit dem Signalübertragungsverhalten von single-bit continuous-time (CT) ΣΔ Modulatoren. Dabei liegt der Fokus der Untersuchung auf dem Peaking der Signaltransferfunktion (STF). Dieser Effekt kann die Performance und die Stabilität des Gesamtsystems negativ beeinflussen, da bei auftretendem STF-Peaking Signale außerhalb des Signalbands verstärkt werden. In dieser Arbeit wird ein neuer Ansatz zur Reduktion des Peakings vorgestellt, der auf der Optimierung der Systemdynamik basiert. Dabei werden die Filterkoeffizienten des Modulators systematisch angepasst. Anhand eines Beispielsystems wird gezeigt, dass der Ansatz genutzt werden kann, um das Übertragungsverhalten des Modulators abhängig vom Ausgangssystem zu verändern. So kann entweder die Systemsperformance verbessert werden, ohne Peaking in der STF zu erzeugen, oder das STF-Peaking reduziert werden, ohne die Systemperformance stark zu beeinflussen.

  17. Berechnung der auftretenden lokalen Kräfte auf der magnetischen Beschichtung eines magnetischen Rasterkraftmikroskops

    NASA Astrophysics Data System (ADS)

    Preisner, T.; Mathis, W.

    2009-05-01

    Die numerische Berechnung entstehender Kraftwirkungen auf Körper aufgrund magnetischer Wechselwirkungen zwischen diesen, ist in Bezug auf die mechanische Deformation dieser Körper ein noch nicht vollständig gelöstes Problem. In dieser Arbeit wird ein Vergleich vorhandener Kraftberechnungsmethoden hinsichtlich der totalen Kraft anhand eines analytisch berechenbaren Beispiels vorgestellt, sowie Unterschiede der lokalen Kraftdichten dieser Methoden in Anwendung auf die magnetische Beschichtung eines magnetischen Rasterkraftmikroskops aufgezeigt. Due to magnetic interactions between magnetic field inducing bodies, force effects occur on the materials. The numerical computation of those occuring forces with respect to a subsequent structural analysis of a deformable material is still a topic of interest in research. In this paper a comparison between several existent force calculation methods regarding the total force is given for an example with two magnetic cubes. Furthermore, differences are shown concerning the local force densities on the magnetic coating of a magnetic force microscope.

  18. Effect of Concomitant Radiochemotherapy on Invasion Potential of Glioblastoma.

    PubMed

    Hutóczki, Gábor; Bognár, László; Tóth, Judit; Scholtz, Beáta; Zahuczky, Gábor; Hanzély, Zoltán; Csősz, Éva; Reményi-Puskár, Judit; Kalló, Gergő; Hortobágyi, Tibor; Klekner, Almos

    2016-01-01

    Glioblastoma (GBM) is the most common primary brain tumor in adults with inevitable recurrence after oncotherapy. The insufficient effect of "gold standard" temozolomide-based concomitant radiochemotherapy may be due to the inability to prevent tumor cell invasion. Peritumoral infiltration depends mainly on the interaction between extracellular matrix (ECM) components and cell membrane receptors. Changes in invasive behaviour after oncotherapy can be evaluated at the molecular level by determining the RNA expression and protein levels of the invasion-related ECM components. The expression of nineteen ECM molecules was determined at both RNA and protein levels in thirty-one GBM samples. Fifteen GBM samples originated from the first surgical procedure on patients before oncotherapy, and sixteen GBM samples were collected at the second surgery due to local recurrence after concomitant chemoirradiation. RNA expressions were measured with qRT-PCR, and protein levels were determined by quantitative analysis of Western blots. Only MMP-9 RNA transcript level was reduced (p < 0.05) whereas at protein level, eight molecules showed changes concordant with RNA expression with significant decrease in brevican only. The results suggest that concomitant radiochemotherapy does not have sufficient impact on the expression of invasion-related ECM components of glioblastoma, oncotherapy does not significantly affect its invasive behavior. To avoid the spread of tumors into the brain parenchyma, supplementation of antiproliferative treatment with anti-invasive agents may be worth consideration in oncotherapy for glioblastoma.

  19. Reinraumtechnik für die Medizintechnik

    NASA Astrophysics Data System (ADS)

    Petek, Max; Jungbluth, Martin; Krampe, Erhard

    Die Reinraumtechnik ist heute ein unverzichtbarer Bestandteil bei der Fertigung von Produkten der Life Sciences, den Bereichen Pharma, Lebensmittel, Kosmetik und Medizintechnik. In Anbetracht der langen Historie der Medizintechnik ist sie jedoch eine sehr junge Disziplin. Die Bedeutung von Keimen und die richtige Einschätzung ihrer Größe wurden zwar sehr früh bereits durch Paracelsus erkannt, jedoch wurden daraus noch keine speziellen oder kontinuierlich umgesetzten Hygienevorschriften abgeleitet. Die erste bekannte technische Umsetzung von Hygieneempfehlungen geht auf den Franzosen François Nicolas Appert zurück, der eine aseptische Abfüllmethode für Lebensmittel entwickelte und diese 1810 veröffentlichte [1]. Die erste dokumentierte medizinische Umsetzung stellten Hygienevorschriften für Ärzte dar, die Ignaz Philipp Semmelweis nach 1847 in der Wiener Klinik für Geburtshilfe einführte [2].

  20. Prevention of Radiochemotherapy-Induced Esophagitis With Glutamine: Results of a Pilot Study

    SciTech Connect

    Algara, Manuel Rodriguez, Nuria; Vinals, Pedro; Lacruz, Marti; Foro, Palmira; Reig, Anna; Quera, Jaume; Lozano, Joan; Fernandez-Velilla, Enric; Membrive, Ismael; Dengra, Josefa; Sanz, Xavier

    2007-10-01

    Purpose: To assess the usefulness of oral glutamine to prevent radiochemotherapy-induced esophagitis in patients with lung cancer, and to determine the dosimetric parameter predictive of esophagitis. Methods and Materials: Seventy-five patients were enrolled; 34.7% received sequential radiochemotherapy, and 65.3% received concomitant radiochemotherapy. Every patient received prophylactic glutamine powder in doses of 10 g/8 h. Prescribed radiation doses were 45-50 Gy to planning target volume (PTV)1 (gross tumor volume plus wide margins) and 65-70 Gy to PTV2 (reduced margins). The primary endpoint was the incidence of Grade 2 or greater acute esophagitis. Results: No patient experienced glutamine intolerance or glutamine-related toxicity. Seventy-three percent of patients who received sequential chemotherapy and 49% of those who received concomitant chemotherapy did not present any form of esophagitis. V50 was the dosimetric parameter with better correlation between esophagitis and its duration. A V50 of {<=}30% had a 22% risk of esophagitis Grade {>=}2, which increased to 71% with a V50 of >30% (p = 0.0009). Conclusions: The use of oral glutamine may have an important role in the prevention of esophageal complications of concomitant radiochemotherapy in lung cancer patients. However, randomized trials are needed to corroborate that effect. V50 is the dosimetric parameter with better correlation with esophagitis grade and duration.

  1. Concomitant radiochemotherapy in unresectable carcinoma of the exocrine pancreas: cost-effectiveness analysis.

    PubMed

    Cellini, N; Costamagna, G; Morganti, A G; Valentini, V; Macchia, G; Mutignani, M; Pandolfi, M; Trodella, L

    1999-01-01

    One of the principal therapeutic options in unresectable carcinoma of exocrine pancreas is concomitant radiochemotherapy. However, in current scientific literature cost analyses of this therapeutic modality are lacking. A payer-oriented cost-effectiveness analysis of concomitant radiochemotherapy was carried out. Outcomes and differences in costs relatively to two different therapeutic strategies were compared retrospectively: biliary drainage + observation (group 1); biliary drainage + concomitant radiochemotherapy (group 2). Cost-effectiveness was assessed based on the analysis of incremental cost of benefit in terms of survival in group 2. As incremental cost of group 2 was considered that of radiochemotherapy, costs of diagnosis and staging being similar in the two groups. The unit of measurement used was $/Lys (LYS = years of life saved). For estimates of cost-effectiveness in different clinical situations, a sensitivity analysis was carried out. The incremental cost of standard concomitant radiochemotherapy was shown to be $4,755. Incremental costs relatively to the situations of minimum and maximum treatment were shown to be $4,410 and $8,375, respectively. Median survival was 4.5 and 10 months in group 1 and 2 respectively (logrank: p = 0.0046). The benefit in terms of survival achieved by concomitant radiochemotherapy was shown to be 5.5 months equal to 0.46 years. Therefore, in the standard situation, the treatment cost-effectiveness can be estimated in: $4,755/0.46 years = $10,337/LYS, that is, the cost of a year of life saved was shown to be $10,337. Results of sensitivity analysis showed that cost-effectiveness can be estimated in the range $7,603 and $25,379/LYS. In conclusion, concomitant radiochemotherapy in patients with unresectable pancreatic carcinoma is able to improve the quality of life through the relief of related symptoms as well as median survival (10 vs 4.5 months). Costs of these benefits, even if considering better survival only, based

  2. SPHERICAL DIE

    DOEpatents

    Livingston, J.P.

    1959-01-27

    A die is presented for pressing powdered materials into a hemispherical shape of uniforin density and wall thickness comprising a fcmale and male die element held in a stationary spaced relation with the space being equivalent to the wall thickness and defining the hemispherical shape, a pressing ring linearly moveable along the male die element, an inlet to fill the space with powdered materials, a guiding system for moving the pressing ring along the male die element so as to press the powdered material and a heating system for heating the male element so that the powdered material is heated while being pressed.

  3. Indikatorenbasierte Bewertung von Entwurfsentscheidungen auf Systemebene

    NASA Astrophysics Data System (ADS)

    Freier, M.; Wenzler, A.; Mayer, T.; Gerlach, J.; Rosenstiel, W.

    2013-07-01

    Bei dem Entwurf von anwendungsspezifischen integrierten Schaltungen muss ein Entwickler zusätzliche Funktionen integrieren und die zunehmende Komplexität bewältigen. Für die Reduzierung der Kosten bleibt weiterhin die Verkürzung der benötigten Entwicklungszeit ein Ziel. Ein entscheidender Faktor dabei ist die zuverlässige Absicherung von Entwurfsentscheidungen in einer frühen Entwurfsphase. In der vorliegenden Arbeit wird eine Methode vorgestellt, die eine Bewertung von Entwurfsentscheidungen bei Systemmodellen mittels automatisch ermittelter Indikatoren ermöglichen soll. Die Systemmodelle können mit der Entwurfsumgebung MATLAB/Simulink oder in SystemC beschrieben sein.

  4. Lymph node positive head and neck carcinoma after curative radiochemotherapy: a long lasting debate on elective post-therapeutic neck dissections comes to a conclusion.

    PubMed

    Hermann, R M; Christiansen, H; Rödel, R M

    2013-01-01

    There has been a long lasting debate, whether planned neck dissections after curative radio(chemo)therapy for locally advanced head and neck squamous cell carcinomas offer some benefit in tumor control or survival. We did a thorough literature research on that topic. The results of several recently published studies are described, summarized, and reviewed. Patients with residual disease in clinical or radiographic examinations (CT or MRI scans) up to 3 months after completion of radiochemotherapy profit from neck dissections. In patients with an initial or delayed clinical complete remission after completion of radiochemotherapy, a neck dissection can be safely omitted. In conclusion, there is no longer evidence for a benefit of prophylactic post-radiochemotherapy neck dissections, but strong evidence for a therapeutic post-radiochemotherapy neck dissection in this group of patients.

  5. Qualitätszentrierte Softwareentwicklung in wissenschaftlichen Arbeitsgruppen Auf dem Weg vom Prototypen zum Produkt

    NASA Astrophysics Data System (ADS)

    Maleike, D.; Neuhaus, J.; Heimann, T.; Nolden, M.; Poxleitner, J.; Schöbinger, M.; Schwarz, T.; Seitel, M.; Wegner, I.; Wolber, P.; Meinzer, H.-P.; Wolf, I.

    Neue Bildverarbeitungsmethoden werden häufig hauptsächlich für Publikationszwecke entwickelt. DieWeiterentwicklung bis zur Verwendbarkeit für klinische Anwender erfordert zusätzlichen Aufwand und wird daher oft nicht weiter verfolgt. In dieser Arbeit wurden mehrere Bildanalyseverfahren unserer Abteilung konsequent zu einem stabilen und benutzbaren Softwareprodukt weiter entwickelt, so dass es für den Einsatz bei klinischen Partnern und als Demonstrationssoftware auf Messen verwendbar ist. Wir beschreiben das Vorgehen bei der Weiterentwicklung, welche Erfahrungen gemacht wurden und welcher zusätzliche Aufwand damit verbunden ist.

  6. Die Schokoladen-Diät

    NASA Astrophysics Data System (ADS)

    Ehrhardt, Matthias

    Schlankheitskuren sind einerseits ein soziales Phänomen, aber auch ein großer Zweig der Nahrungsmittelindustrie. Die Industrie bietet dabei verschiedene Produkte an, wie Diätlebensmittel, Nahrungsergänzungsmittel, Sportkleidung und -ausrüstung, Übungsvideos und -bücher, usw. Allerdings ist es bekanntermaßen sehr schwer, das einmal erreichte Wunschgewicht auch langfristig zu halten. Häufig tritt dabei der so genannte Jojo-Effekt auf, so dass man schließlich nach der Diät mehr wiegt als vorher.

  7. Datenkompression, Prozessoptimierung, Aerodynamik: Eine Tour Durch die Skalen

    NASA Astrophysics Data System (ADS)

    Dahmen, Wolfgang; Marquardt, Wolfgang

    Enorm gestiegene Rechnerkapazitäten ermutigen zu einer immer genaueren Erschließung komplexer Prozesse in Natur- und Ingenieurwissenschaften durch numerische Simulation. Die Mathematik als Schnittstelle zwischen realer und digitaler Welt liefert einerseits die Grundlagen zur Formulierung notwendigerweise vereinfachter Modelle der Realität. Andererseits bietet sie aber auch die methodischen Grundlagen für den Entwurf effizienter Algorithmen, die aus solchen Modellen quantitative Information gewinnen können. Eine zentrale Herausforderung liegt dabei in der Tatsache, dass reale Prozesse meist durch relevante Anteile auf einer riesigen Spannweite von Längenskalen getrieben werden. Die Entwicklung mathematischer Methoden zur Behandlung von Mehrskaligkeit ist daher von wesentlicher Bedeutung. In diesem Artikel wird dies anhand jüngster Entwicklungen in ganz unterschiedlichen Anwendungsbereichen erklärt und illustriert, auch um deutlich zu machen, wieviele "Fliegen“ man mit einer "mathematischen Klappe“ schlagen kann. Insbesondere werden grundlegende, auf Waveletzerlegung beruhende Prinzipien zunächst im Rahmen der Bildkompression und -kodierung auf weitgehend elementare Weise erklärt. Es wird dann aufgezeigt, dass diese Konzepte in ganz ähnlicher Weise bei der Datenanalyse im Zusammenhang mit verfahrenstechnischen Anwendungen, bei großskaligen Optimierungsproblemen der Prozessindustrie sowie bei komplexen Strömungsproblemen wie in aerodynamischen Anwendungen zum Tragen kommen. Stabile Zerlegungen in Anteile unterschiedlicher Längenskalen eröffnen dabei einen Zugang zu adaptiven Lösungskonzepten, die in der Lage sind, automatisch Rechnerresourcen dort zu plazieren, wo sie zu einer ökonomischen Realisierung der gewünschten Lösungsqualität, etwa in Form von Genauigkeitstoleranzen, benötigt werden.

  8. Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers.

    PubMed

    Rades, Dirk; Seidl, Daniel; Janssen, Stefan; Strojan, Primoz; Karner, Katarina; Bajrovic, Amira; Hakim, Samer G; Wollenberg, Barbara; Schild, Steven E

    2017-02-01

    Radio-chemotherapy is a common treatment for locally advanced squamous cell head-and-neck cancers (LA-SCCHN). Cisplatin (100 mg/m(2)) every 3 weeks is very common but associated with considerable toxicity. Therefore, cisplatin programs with lower daily doses were introduced. There is a lack of studies comparing lower-dose programs. In this study, 85 patients receiving radio-chemotherapy with 20 mg/m(2) cisplatin on 5 days every 4 weeks (group A) were retrospectively compared to 85 patients receiving radio-chemotherapy with 30-40 mg/m(2) cisplatin weekly (group B). Groups were matched for nine factors including age, gender, performance score, tumor site, T-/N-category, surgery, hemoglobin before radio-chemotherapy, and radiation technique. One- and 3-year loco-regional control rates were 83 and 69 % in group A versus 74 and 63 % in group B (p = 0.12). One- and 3-year survival rates were 93 % and 73 % in group A versus 91 and 49 % in group B (p = 0.011). On multivariate analysis, survival was significantly better for group A (HR 1.17; p = 0.002). In groups A and B, 12 and 28 % of patients, respectively, did not receive a cumulative cisplatin dose ≥180 mg/m(2) (p = 0.016). Toxicity rates were not significantly different. On subgroup analyses, group A patients had better loco-regional control (p = 0.040) and survival (p = 0.005) than group B patients after definitive radio-chemotherapy. In patients receiving adjuvant radio-chemotherapy, outcomes were not significantly different. Thus, 20 mg/m(2) cisplatin on 5 days every 4 weeks resulted in better loco-regional control and survival in patients receiving definitive radio-chemotherapy and may be preferable for these patients. Confirmation of these results in a randomized trial is warranted.

  9. Sputtered protective coatings for die casting dies

    NASA Technical Reports Server (NTRS)

    Mirtich, M. J.; Nieh, C. Y.; Wallace, J. F.

    1981-01-01

    This investigation determined whether selected ion beam sputtered coatings on H-13 die steel would have the potential of improving the thermal fatigue behavior of the steel used as a die in aluminum die casting. The coatings were selected to test candidate insulators and metals capable of providing protection of the die surface. The studies indicate that 1 micrometer thick W and Pt coatings reduced the thermal fatigue more than any other coating tested and are candidates to be used on a die surface to increase die life.

  10. Die Welt des Herrn Kuhn

    NASA Astrophysics Data System (ADS)

    Kern, Daniela

    Eines Morgens erwachte Herr Kuhn fröstelnd und staunte darüber, dass es in seinerWohnung eiskalt war. Dennoch quälte er sich aus seiner kuscheligen Bettdecke heraus und schlurfte ins Bad. "Hoffentlich wird wenigstens das Wasser warm", dachte er sich, als er den Wasserhahn betätigte - aber es kam nicht nur kein warmesWasser, außer einem unheilvollen Gluckser kam gar nichts aus der Leitung. "Dann werde ich wohl mal den Klempner anrufen", sprach er sich leise in den Bart und griff zu seinem Handy - doch das Netz war tot! Herr Kuhn begann nun, sich ernsthaft Sorgen zu machen, "Oje, was ist denn heute nur los? Ist irgendetwas Schlimmes passiert?" Um einen besseren Überblick über die Lage zu bekommen und sich austauschen zu können, brannte er nun förmlich darauf, rauszugehen und zur Arbeit zu fahren. An anderen Tagen, die er frisch geduscht und mit Kaffee und Marmeladen-Brot begann, war er selten so motiviert. So ging er also nun mit leerem Magen aus dem Haus. Hätte er den Versuch unternommen, sein tägliches Marmeladenbrot zuzubereiten, und dafür den Kühlschrank geöffnet, um das Marmeladenglas herauszunehmen, wäre ihm aufgefallen, dass auch die Stromversorgung Störungen unterworfen war, unschön zu erkennen an den ersten grünen, felligen Inseln auf seinem Lieblingskäse.

  11. [Concurrent radiochemotherapy in the treatment of squamous cell oral and oropharyngeal cancer].

    PubMed

    Semin, D Iu; Medvedev, V S; Marbynskiĭ, Iu S; Gulidov, I A; Isaev, P A; Radzhanova, M U; Derbugov, D N; Pol'kin, V V

    2010-01-01

    The aim of this study was to evaluate the end results of the radiochemotherapy of 237 patients with squamous cell carcinoma of oral mucosa (locally advanced, stage III-IV, - 134; 56.4%, and metastases to regional lymph nodes of the neck - 91; 38.4%) carried out at the Center's Clinic. Interstitial neutron (252 californium) plus polychemotherapy was given to 26 (11%) (group 1); neutron + distant radio + polychemotherapy - 34 (14 %) (group 2); distant fractionated radiotherapy + polychemotherapy - 177 (75%) (group 3). Complete response was reported in 190 (80.2%); partial - 44 (18.6%) and stabilization - 3 (1.3%). Overall response was 98.8%; 5-year survival - 64.5 +/- 3.3%, irrespective of tumor site, grade and method of treatment. Concomitant modality proved highly effective, free from toxic and functional or cosmetic harm.

  12. Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts

    PubMed Central

    Allen, Bryan G.; Bhatia, Sudershan K.; Buatti, John M.; Brandt, Kristin E.; Lindholm, Kaleigh E.; Button, Anna M.; Szweda, Luke I.; Smith, Brian J.; Spitz, Douglas R.; Fath, Melissa A.

    2014-01-01

    Purpose Ketogenic diets (KDs) are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for energy metabolism. Cancer cells (relative to normal cells) are believed to exist in a state of chronic oxidative stress mediated by mitochondrial metabolism. The current study tests the hypothesis that KDs enhance radio-chemo-therapy responses in lung cancer xenografts by enhancing oxidative stress. Experimental Design Mice bearing NCI-H292 and A549 lung cancer xenografts were fed a KD (KetoCal® 4:1 fats: proteins+carbohydrates) and treated with either conventionally fractionated (1.8-2 Gy) or hypofractionated (6 Gy) radiation as well as conventionally fractionated radiation combined with carboplatin. Mice weights and tumor size were monitored. Tumors were assessed for immuno-reactive 4-hydroxy-2-nonenal-(4HNE) modified proteins as a marker of oxidative stress as well as PCNA and γH2AX as indices of proliferation and DNA damage, respectively. Results The KD combined with radiation resulted in slower tumor growth in both NCI-H292 and A549 xenografts (p<0.05), relative to radiation alone. The KD also slowed tumor growth when combined with carboplatin and radiation, relative to control. Tumors from animals fed a KD in combination with radiation demonstrated increases in oxidative damage mediated by lipid peroxidation as determined by 4HNE-modified proteins as well as decreased proliferation as assessed by decreased immunoreactive PCNA. Conclusions These results show that a KD enhances radio-chemo-therapy responses in lung cancer xenografts by a mechanism that may involve increased oxidative stress. PMID:23743570

  13. Wege in die Zukunft

    NASA Astrophysics Data System (ADS)

    Kauermann, Göran; Mosler, Karl

    Die Zukunft stellt große Herausforderungen an die Arbeit der Deutschen Statistischen Gesellschaft. Sie betreffen die gestiegenen Anforderungen der Nutzer von Statistik, die Kommunikationsmöglichkeiten des Internets sowie die Dynamik der statistischen Wissenschaften und ihrer Anwendungsgebiete. Das Kapitel 5 beschreibt, wie sich die Gesellschaft diesen Herausforderungen stellt und welche Ziele sie sich in der wissenschaftlichen Zusammenarbeit und im Kampf gegen das Innumeratentum gesetzt hat.

  14. Sitzungsberichte der Heidelberger Akademie der Wissenschaften> " Jahrgang 1990 Sitzungsber.Heidelberg 90 " "Gott hat die Natur einfältig gemacht, sie aber suchen viel Künste"

    NASA Astrophysics Data System (ADS)

    Zehe, Horst

    Der Aufsatz demonstriert anhand ausgiebig kommentierter zeitgenössischer Zeugnisse Goethes Reaktion auf die Arbeiten Fraunhofers, insbesondere auf die Entdeckung der dunklen Linien im Sonnenspektrum. Den Fehlurteilen Goethes werden dabei die Urteile zeitgenössischer Physiker wie Chladni und J.F.W. Herschel gegenübergestellt. Bislang noch ungedruckte Dokumente aus dem Weimarer Goethe- und Schiller-Archiv belegen, daß sich Goethe nicht nur literarisch mit Fraunhofer beschäftigte, sondern daß er auch dessen Versuche mit Hilfe des Jenaer Universitätsmechanikers Körner getreulich zu wiederholen suchte.

  15. Herschel und die Zukunft der Fern-Infrarot-Astronomie

    NASA Astrophysics Data System (ADS)

    Linz, Hendrik

    2015-06-01

    Schon lange ist die beobachtende Astronomie den engen Grenzen des optisch Sichbaren entwachsen und hat fast alle Bereiche des elektromagnetischen Spektrums für sich dienstbar gemacht. Im sogenannten nahen und mittleren Infrarot (Wellenlängen zwischen 1-30 μm) sowie im Millimeter- und Radio-Regime (Wellenlängen zwischen 1 mm und 10 m) ist die Erdatmosphäre relativ gut durchlässig für elektromagnetische Signale oder hat zumindest eine Vielzahl von spektral begrenzten Transmissionsfenstern, die astronomische Beobachtungen zumindest von höheren Bergen aus möglich machen. Allerdings ist das sogenannte Ferne Infrarot (FIR, 30-300 μm Wellenlänge) von der Erde aus fast völlig unzugänglich für astronomische Beobachtungen. Selbst für die besten Beobachtungsplätze der Erde bleibt die atmosphärische Transmission durch die immense Wasserdampf- Absorption auf ein absolutes Minimum beschränkt. Jedoch erlaubt uns das FIR Zugang zu Informationen, die sehr nützlich sind für die astrophysikalische Forschung und komplementär zu anderen Wellenlängen-Bereichen.

  16. Effect of Pretreatment Anemia on Treatment Outcome of Concurrent Radiochemotherapy in Patients With Head and Neck Cancer

    SciTech Connect

    Fortin, Andre Wang Changshu; Vigneault, Eric

    2008-09-01

    Purpose: To investigate the effect of anemia on outcome of treatment with radiochemotherapy in patients with head-and-neck cancer. Methods and Materials: The data of 196 patients with Stage II-IV head-and-neck cancer treated with concomitant cisplatin-based radiochemotherapy were retrospectively reviewed. Anemia was defined according to World Health Organization criteria as hemoglobin <130 g/L in men and <120 g/L in women. Results: Fifty-three patients were classified as anemic, 143 as nonanemic. The 3-year local control rate of anemic and nonanemic patients was 72% and 85%, respectively (p = 0.01). The 3-year overall survival rate of anemic and nonanemic patients was 52% and 77%, respectively (p = 0.004). In multivariate analysis, anemia was the most significant predictor of local control (hazard ratio, 0.37, p = 0.009) and survival (hazard ratio, 0.47, p = 0.007). A dose-effect relationship was also found for local control (p = .04) and survival (0.04) when grouping by hemoglobin concentration: <120, 120-140, and >140 g/L. Conclusions: Anemia was strongly associated with local control and survival in this cohort of patients with head-and-neck cancer receiving radiochemotherapy.

  17. Systemlieferant und OEM Hersteller für die Medizintechnik und Pharmabranche

    NASA Astrophysics Data System (ADS)

    Jakob, Thomas; Reichenberger, Robert

    Unter einem Original Equipment Manufacturer (OEM) versteht man einen Hersteller fertiger Komponenten oder Produkte, der diese in seinen eigenen Produktionsfabriken produziert, sie aber anschließend nicht selbst in den Handel bringt. Die Anforderungen an einen OEM für die Medizintechnik- und Pharmabranche sind weitaus komplexer und umfangreicher als in anderen Branchen. Diese zusätzlichen Anforderungen haben schließlich auch ihre Berechtigung, da es letztendlich immer um die Gesundheit und das Leben von Menschen geht. Ein OEM muss neben der heute immer stärker geforderten Flexibilität, Schnelligkeit und Wettbewerbsfähigkeit sämtliche für die Medizintechnik- und Pharmabranche erforderlichen Qualitäts- und Prozesssicherheitskriterien erfüllen. Entsprechende Nachweise sind durch regelmäßige Kunden- und Überwachungsaudits zu erbringen. Das Arbeitsumfeld eines OEM für die Medizintechnik- und Pharmabranche bezieht sich somit nicht nur auf die Herstellung der Produkte für seine Kunden, sondern auch auf die Einhaltung sämtlicher Normen, Sicherheitskriterien, regulatorischen Voraussetzungen und Gesetze die zur Herstellung der Produkte notwendig sind.

  18. Combined radiochemotherapy for organ preservation in head and neck cancer: review of literature and personal experience.

    PubMed

    Marmiroli, L; Ausili-Cèfaro, G; Nardone, L; Fiorentino, G; Genovesi, D; Salvi, G

    1997-01-01

    Combined radiochemotherapy is the most common method aimed at improving the rate of clinical response in advanced head and neck cancer. Complete clinical remission may correspond to a significant percentage in organ and/or function preservation. In 1992 a protocol of concomitant radiochemotherapy with continuous infusion of carboplatin for 14 consecutive days at the daily dose of 30 mg/m2 and concomitant radiotherapy with conventional fractionation (1.8 Gy to a total 65-70Gy) was started. Over a 3-year period, 56 patients with advanced head and neck cancer, were treated. In view of organ preservation, 26 patients of this series, though with considerable extent of the disease at diagnosis, were considered candidates for radical surgery: oral cavity 9 patients; oropharynx 9 patients; larynx/hypopharynx 8 patients. A single patient was stage I (hypopharynx); most patients were stage III (7) and IV (17 = 65%); T4 20%, N3 23%. 17/20 patients (70%) showed complete clinical response, 6 partial clinical response with a single non responder (overall response 95%). A patient underwent total glossectomy followed by local recurrence and another patient underwent pharyngolaryngectomy also followed by recurrence. After a mean follow-up from 22 to 60 months, 9 patients were still free of disease (37.5%). Median duration of complete response was 25.6 months. Overall median survival was 26.7 months: 38 months in responders. 2-year survival of patients with complete response was 59%. As for organ preservation, at present 6 over 18 patients (33%) with tumor of the oral cavity or oropharynx and 3 patients with tumors of larynx/hypopharynx have preserved organ and function. As for complete responders, 54.5% of those with tumors of oral cavity or oropharynx and 50% of those with tumors of larynx/hypopharynx, have preserved anatomy and function after at least 2-year follow-up. To-date, in follow-up controls relevant late toxicity has not been observed, showing that to the positive

  19. Aktivitätsmessung auf nukleinsäuremodifizierten Oberflächen

    NASA Astrophysics Data System (ADS)

    Schmidt, Peter Michael

    2003-06-01

    Im Bereich der medizinischen Diagnostik spielen DNA-Chips eine immer wichtigere Rolle. Dabei werden Glas- oder Silikon-Oberflächen mit Tausenden von einzelsträngigen DNA-Fragmenten, sog. Sonden, bestückt, die mit den passenden DNA-Fragmenten in der zugefügten Patientenprobe verschmelzen. Die Auswertung solcher Messungen liefert die Diagnose für Krankheiten wie z.B. Krebs, Alzheimer oder für den Nachweis pathogener Erreger. Durch fortschreitende Miniaturisierung dieser Meßsysteme können bis zu 40.000 Genfragmente des Menschen in einer einzigen Messung analysiert werden. Neben den DNA-Fragmenten können Bio-Chips auch für andere biologische Komponenten wie Antikörper und Proteine eingesetzt werden, wobei bei letzteren neben der Bindung auch die Aktivität ein wichtiger Diagnoseparamter ist. Am Fraunhofer-Institut für medizinische Technik und am Lehrstuhl für Analytische Biochemie der Universität Potsdam wurden im Rahmen einer Doktorarbeit Methoden entwickelt, die es ermöglichen auf nukleinsäuremodifizierten Sensoroberflächen die Aktivität von Proteinen zu messen. Es wurden Nukleinsäuren auf Oberflächen optischer Sensoren verankert. Diese fungierten als Rezeptor für die Proteine sowie auch als Substrat für Restriktionsenzyme, die Nukleinsäuren schneiden und Polymerasen, die Nukleinsäuren synthetisieren und verlängern können. Seine Anwendung fand diese Messmethode in der Messung der Aktivität des Proteins Telomerase, das in 90% aller Tumore erhöhte Aktivität gegenüber gesunden Zellen aufweist. Die Vorteile dieses neuen Assays gegenüber älteren Methoden liegt im Verzicht auf radioaktiv-markierten Komponenten und einer deutlich verkürzten Analysezeit. Die Arbeit schliesst mit einem funktionsfähigen Nachweis der Telomeraseaktivität im Zellextrakt von gesunden und kranken Zellen. Der direkte Einfluß von Hemmstoffen auf die Aktivität konnte sichtbar gemacht werden, und steht daher bei der Entwicklung neuer Tumor-Diagnostika und

  20. Einfluss von Methaneinträgen auf die Hydrochemie des Münsterländer Kiessandzuges

    NASA Astrophysics Data System (ADS)

    Strobel, M.; Wisotzky, F.

    2009-03-01

    The Münsterländer Kiessandzug, a Quaternary trench structure, forms an important groundwater reservoir and is of great importance for the regional drinking water supply in north-west Germany (“Münsterland”). Since 2004, the Ruhr-University Bochum has been investigating the Aldruper Mark, evaluating the quantitative and qualitative potential for drinking water abstraction in the area. Due to intensive agricultural utilisation, a high nitrate influx into groundwater is expected. Therefore, this study was focused on contamination of groundwater with nitrate as well as on the nitrate degradation capacity of the sediments. However, present analyses show low nitrate concentrations and a reductive groundwater environment. To find the causes of these reducing conditions, it is necessary to examine the geological and hydrochemical situation with respect to the environment and the substratum of the investigated area: the MünsterländerCretaceous basin is underlain by Carboniferous sand- and mudstones which are degasing methane to some extent. This methane was detected in deep observation wells in the second aquifer of the Münsterländer Kiessandzug. In its central area, low concentrations of nitrate as well as low sulphate concentrations and positive δ34Ssulfate-isotope data indicate active sulphate reduction is occurring in the groundwater. Furthermore, a corresponding sulphide content was found in these Quaternary soils (“secondary pyrite”). An input of methane in the aquifer is discussed as a possible reason for sulphate reduction in the deep aquifer.

  1. Der Einfluß des Prostomiums auf die Entwicklung der Geschlechtsprodukte des Polychaeten Anaitides mucosa (Phyllodocidae)

    NASA Astrophysics Data System (ADS)

    Röhrkasten, A.

    1983-03-01

    Spermatogenesis and especially oogenesis have been investigated in decerebrate and intact specimens of Anaitides mucosa. The results indicate, in contrast to similar experiments on the related species Eulalia viridis, that decerebration causes an accelerated, but nevertheless qualitative normal growth of coelomic oocytes. The implantation of whole prostomia into the coelom of decerebrate females has no counteractive effects. It is likely that the prostomium exerts its influence via the ventral nerve cord.

  2. Verfahren zur Analyse klimatischer und anthropogener Einflüsse auf die Grundwasserstandsentwicklung

    NASA Astrophysics Data System (ADS)

    Wriedt, Gunter

    2017-03-01

    Limitations in applying the Wiener-Multichannel filter to analyze anthropogenic influences on groundwater level dynamics require a new approach independent from reference observation wells. This article presents a simple approach to analyze the relation between groundwater elevations and climate parameters for groundwater monitoring wells. A theoretical "climatic groundwater level series" is derived from monthly climatic water balances considering the transforming effects of the unsaturated zone and local conditions on groundwater level dynamics. Comparing theoretical groundwater levels with observed groundwater level fluctuations allows analyzing the agreement with the temporal dynamics of climatic parameters as well as detecting possible anthropogenic influences. A total of 284 of 573 groundwater observation wells in Lower Saxony show natural groundwater level dynamics, while artificial impacts were found in 221 wells and 68 wells remain unclear. A classification was therefore possible for 88% of the wells. A high model performance was detected for wells without artificial impacts and with minor artificial impacts. A split-sample cross validation proves the predictive capacity of the model for wells with natural dynamics.

  3. Ausländische Direktinvestitionen - bleibt die Sozialpartnerschaft auf der Strecke?

    NASA Astrophysics Data System (ADS)

    Jansen, Peter; Weingarten, Jörg

    2017-03-01

    Germany attracts ever higher levels of foreign direct investment. This raises the question how these investments affect labour relations, which in this country are characterized by a high importance of co-determination and social partnership. Foreign investors are often perceived as a threat, amongst other things, for co-determination or the rights of the workforce. There is also empirical evidence that points to a negative impact of foreign direct investment on the social partnership model. In contrast, other studies conclude that foreign investors value co-determination. Correspondingly, it is not plausible to consider foreign direct investment generally as threat for the social partnership model.

  4. COX-2 verexpression in pretreatment biopsies predicts response of rectal cancers to neoadjuvant radiochemotherapy

    SciTech Connect

    Smith, Fraser M.; Reynolds, John V. . E-mail: reynoldsjv@stjames.ie; Kay, Elaine W.; Crotty, Paul; Murphy, James O.; Hollywood, Donal; Gaffney, Eoin F.; Stephens, Richard B.; Kennedy, M. John

    2006-02-01

    Purpose: To determine the utility of COX-2 expression as a response predictor for patients with rectal cancer who are undergoing neoadjuvant radiochemotherapy (RCT). Methods and Materials: Pretreatment biopsies (PTB) from 49 patients who underwent RCT were included. COX-2 and proliferation in PTB were assessed by immunohistochemistry (IHC) and apoptosis was detected by TUNEL stain. Response to treatment was assessed by a 5-point tumor-regression grade (TRG) based on the ratio of residual tumor to fibrosis. Results: Good response (TRG 1 + 2), moderate response (TRG 3), and poor response (TRG 4 + 5) were seen in 21 patients (42%), 11 patients (22%), and 17 patients (34%), respectively. Patients with COX-2 overexpression in PTB were more likely to demonstrate moderate or poor response (TRG 3 + 4) to treatment than were those with normal COX-2 expression (p = 0.026, chi-square test). Similarly, poor response was more likely if patients had low levels of spontaneous apoptosis in PTBs (p = 0.0007, chi-square test). Conclusions: COX-2 overexpression and reduced apoptosis in PTB can predict poor response of rectal cancer to RCT. As COX-2 inhibitors are commercially available, their administration to patients who overexpress COX-2 warrants assessment in clinical trials in an attempt to increase overall response rates.

  5. Displaced capillary dies

    DOEpatents

    Kalejs, Juris P.; Chalmers, Bruce; Surek, Thomas

    1984-01-01

    An asymmetrical shaped capillary die made exclusively of graphite is used to grow silicon ribbon which is capable of being made into solar cells that are more efficient than cells produced from ribbon made using a symmetrically shaped die.

  6. Displaced capillary dies

    DOEpatents

    Kalejs, Juris P.; Chalmers, Bruce; Surek, Thomas

    1982-01-01

    An asymmetrical shaped capillary die made exclusively of graphite is used to grow silicon ribbon which is capable of being made into solar cells that are more efficient than cells produced from ribbon made using a symmetrically shaped die.

  7. AUF1 regulation of coding and noncoding RNA.

    PubMed

    White, Elizabeth J F; Matsangos, Aerielle E; Wilson, Gerald M

    2017-03-01

    AUF1 is a family of four RNA-binding proteins (RBPs) generated by alternative pre-messenger RNA (pre-mRNA) splicing, with canonical roles in controlling the stability and/or translation of mRNA targets based on recognition of AU-rich sequences within mRNA 3' untranslated regions. However, recent studies identifying AUF1 target sites across the transcriptome have revealed that these canonical functions are but a subset of its roles in posttranscriptional regulation of gene expression. In this review, we describe recent developments in our understanding of the RNA-binding properties of AUF1 together with their biochemical implications and roles in directing mRNA decay and translation. This is then followed by a survey of newly discovered activities for AUF1 proteins in control of miRNA synthesis and function, including miRNA assembly into microRNA (miRNA)-loaded RNA-induced silencing complexes (miRISCs), miRISC targeting to mRNA substrates, interplay with an expanding network of other cellular RBPs, and reciprocal regulatory relationships between miRNA and AUF1 synthesis. Finally, we discuss recently reported relationships between AUF1 and long noncoding RNAs and regulatory roles on viral RNA substrates. Cumulatively, these findings have significantly expanded our appreciation of the scope and diversity of AUF1 functions in the cell, and are prompting an exciting array of new questions moving forward. WIREs RNA 2017, 8:e1393. doi: 10.1002/wrna.1393 For further resources related to this article, please visit the WIREs website.

  8. The Ambiguous Dying Syndrome

    ERIC Educational Resources Information Center

    Bern-Klug, Mercedes

    2004-01-01

    More than one-half of the 2.4 million deaths that will occur in the United States in 2004 will be immediately preceded by a time in which the likelihood of dying can best be described as "ambiguous." Many people die without ever being considered "dying" or "at the end of life." These people may miss out on the…

  9. HIGH PRESSURE DIES

    DOEpatents

    Wilson, W.B.

    1960-05-31

    A press was invented for subjecting specimens of bismuth, urania, yttria, or thoria to high pressures and temperatures. The press comprises die parts enclosing a space in which is placed an electric heater thermally insulated from the die parts so as not to damage them by heat. The die parts comprise two opposed inner frustoconical parts and an outer part having a double frustoconical recess receiving the inner parts. The die space decreases in size as the inner die parts move toward one another against the outer part and the inner parts, though very hard, do not fracture because of the mode of support provided by the outer part.

  10. Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers

    PubMed Central

    2012-01-01

    Background The purpose of this study was to evaluate neck control outcomes after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancer. Methods We retrospectively reviewed medical records of fifty patients with node-positive head and neck cancer who received definitive radiochemotherapy. Twelve patients subsequently underwent neck dissection for suspicious recurrent or persistent disease. A median dose of 70 Gy (range 60-70.6) was delivered to involved nodes. Response evaluation was performed at a median of 5 weeks after completion of radiotherapy. Results Neck failure was observed in 11 patients and the 3-year regional control (RC) rate was 77.1%. Neck dissection was performed in 10 of the 11 patients; seven of these cases were successfully salvaged, and the ultimate rate of neck control was 92%. The remaining two patients who received neck dissection had negative pathologic results. On univariate analysis, initial nodal size > 2 cm, a less-than-complete response at the primary site, post-radiotherapy nodal size > 1.5 cm, and post-radiotherapy nodal necrosis were associated with RC. On multivariate analysis, less-than-complete primary site response and post-radiotherapy nodal necrosis were identified as independent prognostic factors for RC. Conclusions The neck failure rate after definitive radiochemotherapy without planned neck dissection was 22%. Two-thirds of these were successfully salvaged with neck dissection and the ultimate neck control rate was 92%. Our results suggest that planned neck dissection might not be necessary in patients with complete response of primary site, no evidence of residual lesion > 1.5 cm, or no necrotic lymph nodes at the 1-2 months follow-up evaluation after radiotherapy. PMID:22313843

  11. Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

    SciTech Connect

    Miller, Robert C. Iott, Matthew J.; Corsini, Michele M.

    2009-10-01

    Purpose: To present an overview of Phase III trials in adjuvant therapy for pancreatic cancer and review outcomes at the Mayo Clinic after adjuvant radiochemotherapy (RT/CT) for resected pancreatic cancer. Methods and Materials: A literature review and a retrospective review of 472 patients who underwent an R0 resection for T1-3N0-1M0 invasive carcinoma of the pancreas from 1975 to 2005 at the Mayo Clinic, Rochester, MN. Patients with metastatic or unresectable disease at the time of surgery, positive surgical margins, or indolent tumors and those treated with intraoperative radiotherapy were excluded from the analysis. Median radiotherapy dose was 50.4Gy in 28 fractions, with 98% of patients receiving concurrent 5-fluorouracil- based chemotherapy. Results: Median follow-up was 2.7 years. Median overall survival (OS) was 1.8 years. Median OS after adjuvant RT/CT was 2.1 vs. 1.6 years for surgery alone (p = 0.001). The 2-y OS was 50% vs. 39%, and 5-y was 28% vs. 17% for patients receiving RT/CT vs. surgery alone. Univariate and multivariate analysis revealed that adverse prognostic factors were positive lymph nodes (risk ratio [RR] 1.3, p < 0.001) and high histologic grade (RR 1.2, p < 0.001). T3 tumor status was found significant on univariate analysis only (RR 1.1, p = 0.07). Conclusions: Results from recent clinical trials support the use of adjuvant chemotherapy in resected pancreatic cancer. The role of radiochemotherapy in adjuvant treatment of pancreatic cancer remains a topic of debate. Results from the Mayo Clinic suggest improved outcomes after the administration of adjuvant radiochemotherapy after a complete resection of invasive pancreatic malignancies.

  12. Association Between the Cytogenetic Profile of Tumor Cells and Response to Preoperative Radiochemotherapy in Locally Advanced Rectal Cancer

    PubMed Central

    González-González, María; Garcia, Jacinto; Alcazar, José A.; Gutiérrez, María L.; Gónzalez, Luis M.; Bengoechea, Oscar; Abad, María M.; Santos-Briz, Angel; Blanco, Oscar; Martín, Manuela; Rodríguez, Ana; Fuentes, Manuel; Muñoz-Bellvis, Luis; Orfao, Alberto; Sayagues, Jose M.

    2014-01-01

    Abstract Neoadjuvant radiochemotherapy to locally advanced rectal carcinoma patients has proven efficient in a high percentage of cases. Despite this, some patients show nonresponse or even disease progression. Recent studies suggest that different genetic alterations may be associated with sensitivity versus resistance of rectal cancer tumor cells to neoadjuvant therapy. We investigated the relationship between intratumoral pathways of clonal evolution as assessed by interphase fluorescence in situ hybridization (51 different probes) and response to neoadjuvant radiochemotherapy, evaluated by Dworak criteria in 45 rectal cancer tumors before (n = 45) and after (n = 31) treatment. Losses of chromosomes 1p (44%), 8p (53%), 17p (47%), and 18q (38%) and gains of 1q (49%) and 13q (75%) as well as amplification of 8q (38%) and 20q (47%) chromosomal regions were those specific alterations found at higher frequencies. Significant association (P < 0.05) was found between alteration of 1p, 1q, 11p, 12p, and 17p chromosomal regions and degree of response to neoadjuvant therapy. A clear association was observed between cytogenetic profile of the ancestral tumor cell clone and response to radiochemotherapy; cases presenting with del(17p) showed a poor response to neoadjuvant treatment (P = 0.03), whereas presence of del(1p) was more frequently observed in responder patients (P = 0.0002). Moreover, a significantly higher number of copies of chromosomes 8q (P = 0.004), 13q (P = 0.003), and 20q (P = 0.002) were found after therapy versus paired pretreatment rectal cancer samples. Our results point out the existence of an association between tumor cytogenetics and response to neoadjuvant therapy in locally advanced rectal cancer. Further studies in larger series of patients are necessary to confirm our results. PMID:25474426

  13. Sitzungsberichte der Heidelberger Akademie der Wissenschaften¬Jahrgang 1990 Sitzungsber.Heidelberg 90¬"Gott hat die Natur einfältig gemacht, sie aber suchen viel Künste"

    NASA Astrophysics Data System (ADS)

    Zehe, Horst

    Der Aufsatz demonstriert anhand ausgiebig kommentierter zeitgenössischer Zeugnisse Goethes Reaktion auf die Arbeiten Fraunhofers, insbesondere auf die Entdeckung der dunklen Linien im Sonnenspektrum. Den Fehlurteilen Goethes werden dabei die Urteile zeitgenössischer Physiker wie Chladni und J.F.W. Herschel gegenübergestellt. Bislang noch ungedruckte Dokumente aus dem Weimarer Goethe- und Schiller-Archiv belegen, daß sich Goethe nicht nur literarisch mit Fraunhofer beschäftigte, sondern daß er auch dessen Versuche mit Hilfe des Jenaer Universitätsmechanikers Körner getreulich zu wiederholen suchte.

  14. Radiochemotherapy With Cetuximab, Cisplatin, and Amifostine for Locally Advanced Head and Neck Cancer: A Feasibility Study

    SciTech Connect

    Koukourakis, Michael I.; Karapantzos, Ilias; Daniilidis, Vassilios; Kouskoukis, Constantinos

    2010-05-01

    Purpose: Radiotherapy (RT) combined with cisplatin or cetuximab is the standard of care for patients with locally advanced head/neck cancer (LA-HNC). The feasibility of radiochemotherapy with cisplatin and cetuximab, supported with amifostine, was herein investigated. Methods and Materials: Forty-three patients with LA-HNC were recruited. Conformal hypofractionated/accelerated RT with amifostine cytoprotection (2.7 Gy/fraction, 21 fractions in 4 weeks) was combined with cisplatin (30 mg/m{sup 2}/week) and cetuximab (standard weekly regimen) therapy. The dose of amifostine was individualized according to tolerance. Results: A high daily amifostine dose (750-1,000 mg) was tolerated by 41.8% of patients, and a standard dose (500 mg) was tolerated by 34.9% of patients. A high amifostine dose was linked to reduced RT delays (p = 0.0003). Grade 3 to 4 (3-4) mucositis occurred in 7/43 (16.2%) patients, and fungal infections occurred in 18/43 (41.8%) patients. Radiation dermatitis was not aggravated. Interruption of cetuximab due to acneiform rash was necessary in 23.3% of patients, while amifostine-related fever and rash were not observed. Severe late radiation sequelae consisted of laryngeal edema (9% laryngeal cases) and cervical strictures (33% of hypopharyngeal cases). Good salivary function was preserved in 6/11 (54.5%) nasopharyngeal cancer patients. The complete response rate was 68.5%, reaching 77.2% in patients with minor radiotherapy delays. The 24-month local control and survival rates were 72.3% and 91%, respectively (median follow-up was 13 months.). Conclusions: In this feasibility study, weekly administration of cisplatin and cetuximab was safely combined with accelerated RT, supported with amifostine, at the cost of a high incidence of acneiform rash but a reduced incidence of amifostine-related fever/rash. A high daily dose of amifostine allows completion of therapy with minor delays.

  15. Radio-chemotherapy for bladder cancer: Contribution of chemotherapy on local control

    PubMed Central

    Plataniotis, George A; Dale, Roger G

    2013-01-01

    The purpose of this study was to review the magnitude of contribution of chemotherapy (CT) in the local control of muscle invasive bladder carcinoma in the studies where a combined radio-chemotherapy (RCT) was used (how much higher local control rates are obtained with RCT compared to RT alone). Studies on radiotherapy (RT) and combined RCT, neo-adjuvant, concurrent, adjuvant or combinations, reported after 1990 were reviewed. The mean complete response (CR) rates were significantly higher for the RCT studies compared to RT-alone studies: 75.9% vs 64.4% (Wilcoxon rank-sum test, P = 0.001). Eleven of the included RCT studies involved 2-3 cycles of neo-adjuvant CT, in addition to concurrent RCT. The RCT studies included the one-phase type (where a full dose of RCT was given and then assessment of response and cystectomy for non-responders followed) and the two-phase types (where an assessment of response was undertaken after an initial RCT course, followed 6 wk later by a consolidation RCT for those patients with a CR). CR rates between the two subgroups of RCT studies were 79.6% (one phase) vs 71.6% (two-phase) (P = 0.015). The average achievable tumour control rates, with an acceptable rate of side effects have been around 70%, which may represent a plateau. Further increase in CR response rates demands for new chemotherapeutic agents, targeted therapies, or modified fractionation in various combinations. Quantification of RT and CT contribution to local control using radiobiological modelling in trial designs would enhance the potential for both improved outcomes and the estimation of the potential gain. PMID:24003352

  16. Combined Adjuvant Radiochemotherapy With IMRT/XELOX Improves Outcome With Low Renal Toxicity in Gastric Cancer

    SciTech Connect

    Boda-Heggemann, Judit; Hofheinz, Ralf-Dieter; Weiss, Christel; Mennemeyer, Philipp; Mai, Sabine K.; Hermes, Petra; Wertz, Hansjoerg; Post, Stefan; Massner, Bernd; Hieber, Udo; Hochhaus, Andreas; Wenz, Frederik; Lohr, Frank

    2009-11-15

    Objectives: Adjuvant radiochemotherapy improves survival of patients with advanced gastric cancer. We assessed in two sequential cohorts whether improved radiotherapy technique (IMRT) together with intensified chemotherapy improves outcome vs. conventional three-dimensional conformal radiotherapy (3D-CRT) and standard chemotherapy in these patients while maintaining or reducing renal toxicity. Materials and Methods: Sixty consecutive patients treated for gastric cancer either with 3D-CRT (n = 27) and IMRT (n = 33) were evaluated. More than 70% had undergone D2 resection. Although there was a slight imbalance in R0 status between cohorts, N+ status was balanced. Chemotherapy consisted predominantly of 5-fluorouracil/folinic acid (n = 36) in the earlier cohort and mostly of oxaliplatin/capecitabine (XELOX, n = 24) in the later cohort. Primary end points were overall survival (OS), disease-free survival (DFS), and renal toxicity based on creatinine levels. Results: Median follow-up (FU) of all patients in the 3D-CRT group was 18 months and in the IMRT group 22 months (median FU of surviving patients 67 months in the 3D-CRT group and 25 months in the IMRT group). Overall median survival (and DFS) were 18 (13) months in the 3D-CRT group and both not reached in the IMRT group (p = 0.0492 and 0.0216). Actuarial 2-year survival was 37% and 67% in the 3D-CRT and IMRT groups, respectively. No late renal toxicity >Grade 2 (LENT-SOMA scale) was observed in either cohort. Conclusion: When comparing sequentially treated patient cohorts with similar characteristics, OS and DFS improved with the use of IMRT and intensified chemotherapy without signs of increased renal toxicity.

  17. Radiochemotherapy With Cisplatin and 5-Fluorouracil After Transurethral Surgery in Patients With Bladder Cancer

    SciTech Connect

    Weiss, Christian . E-mail: Christian.Weiss@strahlen.med.uni-erlangen.de; Engehausen, Dirk G.; Krause, Frens S.; Papadopoulos, Thomas; Dunst, Juergen; Sauer, Rolf; Roedel, Claus

    2007-07-15

    Purpose: To give an update on the long-term outcome of an intensified protocol of combined radiochemotherapy (RCT) with 5-fluorouracil (5-FU) and cisplatin after initial transurethral resection of bladder tumor (TURBT) with selective organ preservation in bladder cancer. Methods and Materials: One hundred twelve patients with muscle-invading or high-risk T1 (G3, associated Tis, multifocality, diameter >5 cm) bladder cancer were enrolled in a protocol of TURBT followed by concurrent cisplatin (20 mg/m{sup 2}/day as 30-min infusion) and 5-FU (600 mg/m{sup 2}/day as 120-h continuous infusion), administered on Days 1-5 and 29-33 of radiotherapy. Response to treatment was evaluated by restaging TURBT 4-6 weeks after RCT. In case of invasive residual tumor or recurrence, salvage cystectomy was recommended. Results: Ninety-nine patients (88.4%) had no detectable tumor at restaging TURBT; 71 patients (72%) have been continuously free from local recurrence or distant metastasis. Superficial relapse occurred in 13 patients and muscle-invasive recurrence in 11 patients. Overall and cause-specific survival rates for all patients were 74% and 82% at 5 years, respectively. Of all surviving patients, 82% maintained their own bladder, 79% of whom were delighted or pleased with their urinary condition. Hematologic Grade 3/4 toxicity occurred in 23%/6% and Grade 3 diarrhea in 21% of patients. One patient required salvage cystectomy due to a shrinking bladder. Conclusion: Concurrent RCT with 5-FU/cisplatin has been associated with acceptable acute and long-term toxicity. Overall and cause-specific survival rates are encouraging. More than 80% of patients preserved their well-functioning bladder.

  18. Radiochemotherapy in Patients With Primary Glioblastoma Comparing Two Temozolomide Dose Regimens

    SciTech Connect

    Combs, Stephanie E. Wagner, Johanna; Bischof, Marc; Welzel, Thomas; Edler, Lutz; Rausch, Renate; Wagner, Florian; Zabel-du Bois, Angelika; Debus, Juergen; Schulz-Ertner, Daniela

    2008-07-15

    Purpose: To evaluate toxicity and outcomes in patients with primary glioblastoma (GB) treated with postoperative radiochemotherapy (RCHT) with temozolomide (TMZ) comparing two dose regimens. Methods and Materials: A total of 160 patients with histologically confirmed GB were treated with postoperative RCHT with TMZ. Of the patients, 66 were female and 94 were male, with a median age of 60 years. After the primary diagnosis, a biopsy had been performed in 42 patients; a subtotal and total resection was conducted in 66 and 52 patients. Postoperative radiotherapy was applied with a median dose of 60 Gy with a median fractionation of 5 x 2Gy/week. Concomitant TMZ was prescribed at 50 mg/m{sup 2} in 123 patients (Group A) and at 75 mg/m{sup 2} in 37 patients (Group B). Patients were followed in 3-months intervals, with a median follow-up of 13 months. Results: Overall survival (OS) rates in Group A vs. Group B were 67% and 79% at 1 year and 43% vs. 49% at 2 years, respectively (p = 0.69). Progression-free survival was 49% vs. 54% at 1 year and 22% vs. 29% at 2 years (p = 0.31). Hematologic toxicity was not statistically significant over the 6-week RCHT period except for a significant decrease in platelets during Week 6 (p = 0.01) in Group B. Conclusions: Overall survival seems to be comparable in both groups, although longer follow-up and a larger group of patients are needed to corroborate these results. Lower dosing of TMZ also is associated with a more beneficial toxicity profile.

  19. Die singulation method

    DOEpatents

    Swiler, Thomas P.; Garcia, Ernest J.; Francis, Kathryn M.

    2013-06-11

    A method is disclosed for singulating die from a semiconductor substrate (e.g. a semiconductor-on-insulator substrate or a bulk silicon substrate) containing an oxide layer (e.g. silicon dioxide or a silicate glass) and one or more semiconductor layers (e.g. monocrystalline or polycrystalline silicon) located above the oxide layer. The method etches trenches through the substrate and through each semiconductor layer about the die being singulated, with the trenches being offset from each other around at least a part of the die so that the oxide layer between the trenches holds the substrate and die together. The trenches can be anisotropically etched using a Deep Reactive Ion Etching (DRIE) process. After the trenches are etched, the oxide layer between the trenches can be etched away with an HF etchant to singulate the die. A release fixture can be located near one side of the substrate to receive the singulated die.

  20. Die singulation method

    DOEpatents

    Swiler, Thomas P [Albuquerque, NM; Garcia, Ernest J [Albuquerque, NM; Francis, Kathryn M [Rio Rancho, NM

    2014-01-07

    A method is disclosed for singulating die from a semiconductor substrate (e.g. a semiconductor-on-insulator substrate or a bulk silicon substrate) containing an oxide layer (e.g. silicon dioxide or a silicate glass) and one or more semiconductor layers (e.g. monocrystalline or polycrystalline silicon) located above the oxide layer. The method etches trenches through the substrate and through each semiconductor layer about the die being singulated, with the trenches being offset from each other around at least a part of the die so that the oxide layer between the trenches holds the substrate and die together. The trenches can be anisotropically etched using a Deep Reactive Ion Etching (DRIE) process. After the trenches are etched, the oxide layer between the trenches can be etched away with a HF etchant to singulate the die. A release fixture can be located near one side of the substrate to receive the singulated die.

  1. Sputtered protective coatings for die casting dies

    NASA Technical Reports Server (NTRS)

    Mirtich, M. J.; Nieh, C.-Y.; Wallace, J. F.

    1981-01-01

    Three experimental research designs investigating candidate materials and processes involved in protective die surface coating procedures by sputter deposition, using ion beam technologies, are discussed. Various pre-test results show that none of the coatings remained completely intact for 15,000 test cycles. The longest lifetime was observed for coatings such as tungsten, platinum, and molybdenum which reduced thermal fatigue, but exhibited oxidation and suppressed crack initiation only as long as the coating did not fracture. Final test results confirmed earlier findings and coatings with Pt and W proved to be the candidate materials to be used on a die surface to increase die life. In the W-coated specimens, which remained intact on the surface after thermal fatigue testing, no oxidation was found under the coating, although a few cracks formed on the surface where the coating broke down. Further research is planned.

  2. Extrusion die and method

    DOEpatents

    Lipp, G. Daniel

    1994-04-26

    A method and die apparatus for manufacturing a honeycomb body of rhombic cell cross-section by extrusion through an extrusion die of triangular cell discharge slot configuration, the die incorporating feedholes at selected slot intersections only, such that slot segments communicating directly with the feedholes discharge web material and slot segments not so connected do not discharge web material, whereby a rhombic cell cross-section in the extruded body is provided.

  3. The Angry Dying Patient.

    PubMed

    Houston, Robert E.

    1999-02-01

    Over 25 years ago, Kubler-Ross identified anger as a predictable part of the dying process. When the dying patient becomes angry in the clinical setting, all types of communication become strained. Physicians can help the angry dying patient through this difficult time by using 10 rules of engagement. When physicians engage and empathize with these patients, they improve the patient's response to pain and they reduce patient suffering. When physicians educate patients on their normal responses to dying and enlist them in the process of family reconciliation, they can impact the end-of-life experience in a positive way.

  4. Targeting DNA Damage Response in the Radio(Chemo)therapy of Non-Small Cell Lung Cancer

    PubMed Central

    Li, Ling; Zhu, Tao; Gao, Yuan-Feng; Zheng, Wei; Wang, Chen-Jing; Xiao, Ling; Huang, Ma-Sha; Yin, Ji-Ye; Zhou, Hong-Hao; Liu, Zhao-Qian

    2016-01-01

    Lung cancer is the leading cause of cancer death worldwide due to its high incidence and mortality. As the most common lung cancer, non-small cell lung cancer (NSCLC) is a terrible threat to human health. Despite improvements in diagnosis and combined treatments including surgical resection, radiotherapy and chemotherapy, the overall survival for NSCLC patients still remains poor. DNA damage is considered to be the primary cause of lung cancer development and is normally recognized and repaired by the intrinsic DNA damage response machinery. The role of DNA repair pathways in radio(chemo)therapy-resistant cancers has become an area of significant interest in the clinical setting. Meanwhile, some studies have proved that genetic and epigenetic factors can alter the DNA damage response and repair, which results in changes of the radiation and chemotherapy curative effect in NSCLC. In this review, we focus on the effect of genetic polymorphisms and epigenetic factors such as miRNA regulation and lncRNA regulation participating in DNA damage repair in response to radio(chemo)therapy in NSCLC. These may provide novel information on the radio(chemo)therapy of NSCLC based on the individual DNA damage response. PMID:27258253

  5. Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant

    SciTech Connect

    Schirmer, Markus Anton; Mergler, Caroline Patricia Nadine; Rave-Fraenk, Margret; Herrmann, Markus Karl; Hennies, Steffen; Gaedcke, Jochen; Conradi, Lena-Christin; Jo, Peter; Beissbarth, Tim; Hess, Clemens Friedrich; Becker, Heinz; Ghadimi, Michael; Brockmoeller, Juergen; Christiansen, Hans; Wolff, Hendrik Andreas

    2012-05-01

    Purpose: Transforming growth factor-beta1 is related to adverse events in radiochemotherapy. We investigated TGFB1 genetic variability in relation to quality of life-impairing acute organ toxicity (QAOT) of neoadjuvant radiochemotherapy under clinical trial conditions. Methods and Materials: Two independent patient cohorts (n = 88 and n = 75) diagnosed with International Union Against Cancer stage II/III rectal cancer received neoadjuvant radiation doses of 50.4 Gy combined with 5-fluorouracil-based chemotherapy. Toxicity was monitored according to Common Terminology Criteria for Adverse Events. QAOT was defined as a CTCAE grade {>=}2 for at least one case of enteritis, proctitis, cystitis, or dermatitis. Nine germline polymorphisms covering the common genetic diversity in the TGFB1 gene were genotyped. Results: In both cohorts, all patients carrying the TGFB1 Pro25 variant experienced QAOT (positive predictive value of 100%, adjusted p = 0.0006). In a multivariate logistic regression model, gender, age, body mass index, type of chemotherapy, or disease state had no significant impact on QAOT. Conclusion: The TGFB1 Pro25 variant could be a relevant marker for individual treatment stratification and carriers may benefit from adaptive clinical care or specific radiation techniques.

  6. Influence of enteral glutamine on inflammatory and hormonal response in patients with rectal cancer during preoperative radiochemotherapy.

    PubMed

    Rotovnik Kozjek, N; Kompan, L; Žagar, T; Mrevlje, Ž

    2017-03-08

    We conducted a randomized double-blind placebo-controlled study evaluating the influence of 5 weeks' duration of 30 g enteral glutamine supplementation on inflammatory and hormonal responses in 73 patients with rectal cancer undergoing preoperative radiochemotherapy. Plasma levels of inflammatory and hormonal parameters were controlled at the beginning and at the end of supplementation. Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5±3.8 versus 11.1±19.9 ng/l (P=0.02) for IL-6 and 386±168.4 to 312.7±111.7 nmol/l (P=0.03) for cortisol. We conclude that enteral glutamine exhibits some anti-inflammatory activity and, consequently, leads to a lower hormonal stress response during radiochemotherapy in patients with rectal cancer.European Journal of Clinical Nutrition advance online publication, 8 March 2017; doi:10.1038/ejcn.2017.11.

  7. On the stability of AuFe alloy nanoparticles.

    PubMed

    Velasco, V; Pohl, D; Surrey, A; Bonatto-Minella, A; Hernando, A; Crespo, P; Rellinghaus, B

    2014-05-30

    AuFe nanoparticles with mean diameters d p  = 13.2 nm have been prepared by inert-gas condensation. Conventional and high-resolution transmission electron microscopy and energy-dispersive x-ray spectroscopy investigations show that the particles are mostly icosahedra. Scanning transmission electron microscopy-energy-dispersive x-ray spectroscopy and scanning transmission electron microscopy-electron energy-loss spectroscopy show that the as-grown particles exhibit a core-shell structure. The shell is mainly composed of an amorphous FeO layer. Although Fe and Au are immiscible in the bulk, the particle cores are found to be homogeneously mixed at the atomic level with a local composition of around Au84Fe16 (at.%). AuFe nanoparticles exhibit a complex magnetic structure in which the core behaves as a spin glass with a freezing temperature of 35 K, whereas the amorphous FeO shell behaves as a ferro-ferrimagnetic system. On annealing above 300 °C, the AuFe icosahedra phases separate into their elemental constituents. Hence the as-grown AuFe icosahedra are metastable, thereby implying that the bulk phase diagram also applies for nanoscopic materials.

  8. Physik gestern und heute Die Messung elektrostatischer Kräfte

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2002-11-01

    Im Jahre 1785 veröffentlichte der französische Militäringenieur Charles Augustin Coulomb das Kraft-Abstand-Gesetz für elektrische Ladungen. Bereits zuvor hatte Henry Cavendish auf andere Art und Weise diese Beziehung nachgewiesen, aber nicht publiziert. Entsprechende Experimente wurden auch noch in jüngerer Zeit ausgeführt, da sie eine obere Abschätzung für die Ruhemasse des Photons erlauben.

  9. Radio-chemotherapy improves survival in IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma patients.

    PubMed

    Juratli, Tareq A; Lautenschläger, Tim; Geiger, Kathrin D; Pinzer, Thomas; Krause, Mechthild; Schackert, Gabriele; Krex, Dietmar

    2015-09-01

    Isocitrate dehydrogenase (IDH) mutations are beginning to drive decisions on therapy for glioma patients. Here we sought to determine the impact of adjuvant treatment in patients with IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma (sHGA) WHO grades III/IV. Clinical data of 109 sHGA patients grades III/IV, in addition to IDH mutation-, 1p/19q-codeletion- and MGMT-promoter methylation status-were retrospectively analyzed. Survival analysis in relation to adjuvant treatment modalities and molecular profiling were performed. Out of 109 patients, 88 patients (80.7 %) harbored IDH mutations, 30 patients had a 1p/19q-codeletion (27.5 %) and 69 patients (63.3 %) exhibited a methylated MGMT-promoter status. At a median follow-up of 9.8 years, 62 patients (57 %) died. The postsurgical treatment included: radio-chemotherapy (RT-CT; 54.5 %), RT alone (19.3 %), and CT alone (22.7 %). The median overall survival (OS) in the entire group was 3.4 years (1.9-6.7 years). Patients who received RT-CT had a significantly longer OS compared with those who underwent RT alone (6.5 vs. 1.2 years, HR 0.35, CI 0.32-0.51, p = 0.011). In the IDH-mutant 1p/19q non-codeleted sHGA subgroup the RT-CT cohort had a significantly longer OS in comparison to the RT cohort (6.4 vs. 1.2 years, HR 2.7, CI 1.1-6.5, p = 0.022). In the stepwise multivariable Cox model for OS of all 88 IDH-mutant sHGA patients, survival was strongly associated with only one factor, namely, adjuvant RT-CT at diagnosis of a sHGA. This retrospective long-term study demonstrates that RT and CT (mostly PCV) significantly improves progression-free and overall survival in IDH-mutant secondary high-grade astrocytoma patients, regardless of 1p/19q-codeletion status.

  10. Die Soldering in Aluminium Die Casting

    SciTech Connect

    Han, Q.; Kenik, E.A.; Viswanathan, S.

    2000-03-15

    Two types of tests, dipping tests and dip-coating tests were carried out on small steel cylinders using pure aluminum and 380 alloy to investigate the mechanism of die soldering during aluminum die casting. Optical and scanning electron microscopy were used to study the morphology and composition of the phases formed during soldering. A soldering mechanism is postulated based on experimental observations. A soldering critical temperature is postulated at which iron begins to react with aluminum to form an aluminum-rich liquid phase and solid intermetallic compounds. When the temperature at the die surface is higher than this critical temperature, the aluminum-rich phase is liquid and joins the die with the casting during the subsequent solidification. The paper discusses the mechanism of soldering for the case of pure aluminum and 380 alloy casting in a steel mold, the factors that promote soldering, and the strength of the bond formed when soldering occurs. conditions, an aluminum-rich soldering layer may also form over the intermetallic layer. Although a significant amount of research has been conducted on the nature of these intermetallics, little is known about the conditions under which soldering occurs.

  11. Is Dying Young Worse than Dying Old?

    ERIC Educational Resources Information Center

    Jecker, Nancy S.; Schneiderman, Lawrence J.

    1994-01-01

    Notes that, in contemporary Western society, people feel death of small child is greater injustice than death of older adult and experience correspondingly greater sorrow, anger, regret, or bitterness when very young person dies. Contrasts these attitudes with those of ancient Greece and shows relevance that different attitudes toward death have…

  12. Micromechanical die attachment surcharge

    DOEpatents

    Filter, William F.; Hohimer, John P.

    2002-01-01

    An attachment structure is disclosed for attaching a die to a supporting substrate without the use of adhesives or solder. The attachment structure, which can be formed by micromachining, functions purely mechanically in utilizing a plurality of shaped pillars (e.g. round, square or polygonal and solid, hollow or slotted) that are formed on one of the die or supporting substrate and which can be urged into contact with various types of mating structures including other pillars, a deformable layer or a plurality of receptacles that are formed on the other of the die or supporting substrate, thereby forming a friction bond that holds the die to the supporting substrate. The attachment structure can further include an alignment structure for precise positioning of the die and supporting substrate to facilitate mounting the die to the supporting substrate. The attachment structure has applications for mounting semiconductor die containing a microelectromechanical (MEM) device, a microsensor or an integrated circuit (IC), and can be used to form a multichip module. The attachment structure is particularly useful for mounting die containing released MEM devices since these devices are fragile and can otherwise be damaged or degraded by adhesive or solder mounting.

  13. Extrusion die and method

    DOEpatents

    Lipp, G. Daniel

    1994-05-03

    A method and die apparatus for manufacturing a honeycomb body of triangular cell cross-section and high cell density, the die having a combination of (i) feedholes feeding slot intersections and (ii) feedholes feeding slot segments not supplied from slot intersections, whereby a reduction in feedhole count is achieved while still retaining good extrusion efficiency and extrudate uniformity.

  14. Early and late stage positron emission tomography (PET) studies on the haemocirculation and metabolism of seemingly normal brain tissue in patients with gliomas following radiochemotherapy.

    PubMed

    Mineura, K; Suda, Y; Yasuda, T; Kowada, M; Ogawa, T; Shishido, F; Uemura, K

    1988-01-01

    Haemocirculatory and metabolic changes in seemingly normal brain tissue following radiochemotherapy including nimustine hydrochloride (ACNU) and tegafur (FT) were analyzed using oxygen-15 and fluorine-18 positron emission tomography (PET) in seven patients with gliomas. At an early stage (within one month) after radiochemotherapy, marginal increases in regional cerebral blood flow (rCBF) and cerebral blood volume (rCBV) were found contralateral to the tumour in gray matter which was apparently normal brain structure, as seen on computerized tomography (CT). The oxygen extraction fraction (rOEF) decreased significantly (p less than 0.05 by a paired-t test) from that of the pretreatment study, due to surgical decompression and radiochemotherapy. At the late stage (three to thirty-one months with a mean of thirteen months), rCBF decreased significantly from the early stage study (p less than 0.05); oxygen consumption (rCMRO2) fell in all cases significantly from the pretreatment study (p less than 0.01) and from the early stage study (p less than 0.05); consequently, rOEF remained unchanged at a level similar to the early stage study. Glucose consumption (rCMRG1) increased slightly as compared with the early stage study but failed to be restored to the level of the pretreatment study. Noteworthy was a coupling reduction of rCBF and rCMRO2--presumably, a late delayed effect of radiochemotherapy. These preliminary results indicate that with PET studies it may be possible to predict damage to normal brain tissue after radiochemotherapy.

  15. RNA-Binding Protein AUF1 Promotes Myogenesis by Regulating MEF2C Expression Levels

    PubMed Central

    Panda, Amaresh C.; Abdelmohsen, Kotb; Yoon, Je-Hyun; Martindale, Jennifer L.; Yang, Xiaoling; Curtis, Jessica; Mercken, Evi M.; Chenette, Devon M.; Zhang, Yongqing; Schneider, Robert J.; Becker, Kevin G.; de Cabo, Rafael

    2014-01-01

    The mammalian RNA-binding protein AUF1 (AU-binding factor 1, also known as heterogeneous nuclear ribonucleoprotein D [hnRNP D]) binds to numerous mRNAs and influences their posttranscriptional fate. Given that many AUF1 target mRNAs encode muscle-specific factors, we investigated the function of AUF1 in skeletal muscle differentiation. In mouse C2C12 myocytes, where AUF1 levels rise at the onset of myogenesis and remain elevated throughout myocyte differentiation into myotubes, RNP immunoprecipitation (RIP) analysis indicated that AUF1 binds prominently to Mef2c (myocyte enhancer factor 2c) mRNA, which encodes the key myogenic transcription factor MEF2C. By performing mRNA half-life measurements and polysome distribution analysis, we found that AUF1 associated with the 3′ untranslated region (UTR) of Mef2c mRNA and promoted MEF2C translation without affecting Mef2c mRNA stability. In addition, AUF1 promoted Mef2c gene transcription via a lesser-known role of AUF1 in transcriptional regulation. Importantly, lowering AUF1 delayed myogenesis, while ectopically restoring MEF2C expression levels partially rescued the impairment of myogenesis seen after reducing AUF1 levels. We propose that MEF2C is a key effector of the myogenesis program promoted by AUF1. PMID:24891619

  16. Death, dying, and domination.

    PubMed

    Spindelman, Marc

    2008-06-01

    This Article critiques conventional liberal arguments for the right to die on liberal grounds. It contends that these arguments do not go far enough to recognize and address private, and in particular structural, forms of domination. It presents an alternative that does, which is thus more respectful of true freedom in the context of death and dying, and also more consistent with liberalism. After discussing obstacles to the achievement of a right to die that encompasses freedom from both public and private domination, the Article closes with a significant reform project within bioethics that might help bring it about.

  17. Darwin, Engels und die Rolle der Arbeit in der biologischen und kulturellen Evolution des Menschen

    NASA Astrophysics Data System (ADS)

    Reichholf, Josef H.

    Im Jahre 1876, 5 Jahre nach Erscheinen von Darwins Buch über die Evolution des Menschen und die sexuelle Selektion (Darwin 1871), veröffentlichte Friedrich Engels den berühmt gewordenen Essay "Anteil der Arbeit an der Menschwerdung des Affen“ (Engels 1876). Die Kernfrage darin lautet in Kurzform: Warum hat der Mensch eigentlich ein Bedürfnis nach Arbeit? Engels Antwort wird nachfolgend näher betrachtet und vom gegenwärtigen Kenntnisstand aus beurteilt. Wie sich zeigen wird, beantworten seine Überlegungen die Frage nicht wirklich. Sie ist weiterhin offen. Es können lediglich einige zusätzliche Anhaltspunkte zur Diskussion gestellt werden. Angesichts des drängenden Problems millionenfacher Arbeitslosigkeit und der Forderungen nach einem "Grundrecht auf Arbeit“ kommt den Überlegungen zum möglichen Ursprung des Bedürfnisses nach Arbeit mehr als nur akademisches Interesse zu.

  18. Indication of pre-surgical radiochemotherapy enhances psychosocial morbidity among patients with resectable locally advanced rectal cancer.

    PubMed

    Bencova, V; Krajcovicova, I; Svec, J

    2016-01-01

    Patients with cancer experience stress-determined psychosocial comorbidities and behavioural alterations. Patients expectation to be cured by the first line surgery and their emotional status can be negatively influenced by the decision to include neoadjuvant long-course radiotherapy prior to surgical intervention. From the patient's perspective such treatment algorithmindicates incurability of the disease. The aim of this study was to analyse the extent and dynamics of stress and related psychosocial disturbances among patients with resectable rectal cancer to whom the neoadjuvant radiochemotherapy before surgery has been indicated.Three standardised assessment tools evaluating psychosocial morbidity of rectal cancer patients have been implemented: The EORTC QLQ C30-3, the EORTC QLQ CR29 module and the HADS questionnaires previously tested for internal consistency were answered by patients before and after long-course radiotherapy and after surgery and the scores of clinical and psychosocial values were evaluated by means of the EORTC and HADS manuals. The most profound psychosocial distress was experienced by patients after the decision to apply neoadjuvant radiotherapy and concomitant chemotherapy before surgical intervention. The involvement of pre-surgical radiotherapy into the treatment algorithm increased emotional disturbances (anxiety, feelings of hopelessness) and negatively influenced patient's treatment adherence and positive expectations from the healing process. The negative psychosocial consequences appeared to be more enhanced in female patients. Despite provided information about advances of neoadjuvant radiotherapy onto success of surgical intervention, the emotional and cognitive disorders improved only slightly. The results clearly indicate that addressed communication and targeted psychosocial support has to find place before pre-surgical radiochemotherapy and as a standard part through the trajectory of the entire multimodal rectal cancer

  19. Reduction of radiochemotherapy-induced early oral mucositis by recombinant human keratinocyte growth factor (palifermin): Experimental studies in mice

    SciTech Connect

    Doerr, Wolfgang . E-mail: doerr@rcs.urz.tu-dresden.de; Baessler, Stefan; Reichel, Sandra; Spekl, Kathrin

    2005-07-01

    Purpose: To study the effect of recombinant human keratinocyte growth factor (rHuKGF or palifermin) on oral mucositis induced by radiochemotherapy in a mouse model. Methods and Materials: Cis-diamminedichloroplatinum (cisplatin) and/or 5-fluorouracil were given before single dose irradiation, combined with palifermin before or after the treatment, or both. Daily fractionated irradiation for 2 weeks was followed by graded test doses. With additional chemotherapy in Week 1, palifermin was given before radiotherapy and at the end of the first week, or additionally at the end of Week 2. Radiochemotherapy in Week 2 was combined with palifermin at the end of Weeks 1 and 2, Weeks 1, 2, and 3, or additionally before radiotherapy. Ulceration of mouse tongue mucosa was analyzed as the endpoint. Results: The dose associated with ulcer induction in 50% of the mice (ED{sub 50}) for single-dose irradiation was 11.5 {+-} 0.7 Gy. Palifermin increased the ED{sub 50} to about 19 Gy in all protocols tested. Similar values were observed when chemotherapy was added before irradiation. With fractionated irradiation, palifermin increased the ED{sub 50} for test irradiation from 5.7 {+-} 1.5 Gy to 12-15 Gy, depending on the administration protocol. With chemotherapy in Week 1, two palifermin injections had no significant effect, but a third injection increased the ED{sub 50} to 13 Gy. With chemotherapy in Week 2, all palifermin protocols resulted in ED{sub 50} values of 13-14 Gy. Conclusion: A marked increase in oral mucosal radiation tolerance by palifermin was found, which was preserved in combinations with chemotherapy using cisplatin and/or 5-fluorouracil.

  20. Interaktive Visualisierung von Abständen und Ausdehnungen anatomischer Strukturen für die Interventionsplanung

    NASA Astrophysics Data System (ADS)

    Rössling, Ivo; Cyrus, Christian; Dornheim, Lars; Hahn, Peter; Preim, Bernhard; Boehm, Andreas

    Im Rahmen der Interventionsplanung muss der Chirurg therapierelevante Entscheidungen auf Basis räumlicher Relationen anatomischer Strukturen treffen. Interaktive 3D-Visualisierungen unterstützen diesen Prozess qualitativ. Quantitative Fragestellungen (Tumorausdehnung, Infiltrationstiefe, etc.) erfordern die Integration einer Bemaßung, deren Nutzen wesentlich von einer geeigneten Darstellung abhängt. In dieser Arbeit haben wir allgemeine Kriterien für die Eignung von Visualisierungen von Bemaßungen in interaktiven 3D-Szenen erarbeitet. Daran orientierend haben wir verschiedene Varianten der Darstellung von Abständen und Ausdehnungen anatomischer Strukturen betrachtet und ihr Erscheinungsbild hierzu zweckmäßig parametrisiert. Die Ausprägungen dieser Darstellungsparameter wurden in einer Studie auf ihre visuellen Wirkung hin an Chirurgen evaluiert. Es zeigte sich, dass die befragten Mediziner höchsten Wert auf Kohärenz und klare Zuordnung der Bemaßung setzten und überraschenderweise dafür sogar Abstriche in der direkten Lesbarkeit in Kauf nahmen.

  1. Analyse unterschiedlicher Modellierungsvarianten des "Direct Power Injection" Verfahrens für die EMV Charakterisierung integrierter Schaltungen

    NASA Astrophysics Data System (ADS)

    Stürmer, U.; Ritzmann, S.; Jovic, O.; Wilkening, W.

    2009-05-01

    Dieser Beitrag analysiert zwei Ansätze zur Modellierung eines Teststandes zur Charakterisierung von integrierten Schaltungen mittels Direct Power Injection (DPI) auf einem Wafer. Die erste Variante ist zur Analyse bereits vorliegender integrierter Schaltungen nutzbar. Sie benötigt gemessene S-Parameterdaten, mit denen die an einem realen Messobjekt anliegenden Störspannungen frequenzabhängig bestimmt werden können. Die zweite Variante ist bereits anwendbar, bevor Silizium gefertigt worden ist. Sie modelliert einen Netzwerkanalysatorkanal der aus einer Signalquelle, einem Leistungsmesser und einem Verstärker mit nachgeschaltetem Richtkoppler und Entkoppelnetzwerken besteht. Zunächst werden die oben genannten verschiedenen Varianten der DPI-Streckenmodellierung dargestellt. Sie werden miteinander und anhand von Messdaten einer einfachen Teststruktur verglichen. Die Teststruktur besteht aus einem MOS-Transistor mit Arbeitswiderstand. Der Beitrag diskutiert Vor- und Nachteile der Varianten einschließlich Modellierungsaufwand und Simulationsgeschwindigkeit.

  2. Co-Expression of Bmi-1 and Podoplanin Predicts Overall Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Radio(chemo)therapy

    SciTech Connect

    Vormittag, Laurenz; Thurnher, Dietmar; Geleff, Silvana; Pammer, Johannes; Heiduschka, Gregor; Brunner, Markus; Grasl, Matthaeus Ch.; Erovic, Boban M.

    2009-03-01

    Purpose: This study was conducted to determine the expression of Bmi-1 and podoplanin in healthy oral mucosa and in untreated tumor tissues samples of patients with squamous cell carcinomas of the head and neck. All patients were treated by primary radio(chemo)therapy. Methods and Materials: The expression of Bmi-1 and podoplanin was immunohistochemically evaluated in 12 normal oral mucosa and 63 tumor specimens and correlated with patients' clinical data. Results: In healthy mucosa expression of Bmi-1 and podoplanin was restricted to the basal cell layer. Expression of both proteins was found in 79% and 86% of our tumor samples, respectively. In 17 and 8 samples, Bmi-1 and podoplanin were co-expressed at the invasive border or diffuse in the bulk of the tumor, respectively. Univariate analysis showed that the co-expression of Bmi-1 and podoplanin correlated to decreased overall survival (p = 0.044). Moreover, multivariate testing identified high expression of podoplanin (p = 0.044), co-expression of Bmi-1 and podoplanin (p = 0.007) and lack of response to therapy (p < 0.0001) as predictors of shortened overall survival in patients treated with primary radio(chemo)therapy. Conclusions: Bmi-1 and podoplanin are expressed at the invasive front of squamous cell carcinomas of the head and neck. Co-expression of Bmi-1 and podoplanin predicts significantly overall survival of patients treated with primary radio(chemo)therapy.

  3. Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1

    PubMed Central

    Zucconi, Beth E.; Wilson, Gerald M.

    2013-01-01

    The mRNA-binding protein AUF1 regulates the expression of many key players in cancer including proto-oncogenes, regulators of apoptosis and the cell cycle, and pro-inflammatory cytokines, principally by directing the decay kinetics of their encoded mRNAs. Most studies support an mRNA-destabilizing role for AUF1, although other findings suggest additional functions for this factor. In this review, we explore how changes in AUF1 isoform distribution, subcellular localization, and post-translational protein modifications can influence the metabolism of targeted mRNAs. However, several lines of evidence also support a role for AUF1 in the initiation and/or development of cancer. Many AUF1-targeted transcripts encode products that control pro- and anti-oncogenic processes. Also, overexpression of AUF1 enhances tumorigenesis in murine models, and AUF1 levels are enhanced in some tumors. Finally, signaling cascades that modulate AUF1 function are deregulated in some cancerous tissues. Together, these features suggest that AUF1 may play a prominent role in regulating the expression of many genes that can contribute to tumorigenic phenotypes, and that this post-transcriptional regulatory control point may be subverted by diverse mechanisms in neoplasia. PMID:21622178

  4. Comparison of Four Cisplatin-Based Radiochemotherapy Regimens for Nonmetastatic Stage III/IV Squamous Cell Carcinoma of the Head and Neck;Head-and-neck cancer; Cisplatin-based radiochemotherapy; Toxicity; Treatment outcomes

    SciTech Connect

    Rades, Dirk; Kronemann, Stefanie; Meyners, Thekla; Bohlen, Guenther; Tribius, Silke; Kazic, Nadja; Schroeder, Ursula; Hakim, Samer G.; Schild, Steven E.; Dunst, Juergen

    2011-07-15

    Purpose: To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck. Methods and Materials: Concurrent chemotherapy consisted of three courses of cisplatin 100 mg/m{sup 2} on Day 1 (Group A, n = 74), two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 plus 5-fluorouracil 1,000 mg/m{sup 2} on Days 1-5 (Group B, n = 49), two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 plus 5-fluorouracil 600 mg/m{sup 2} on Days 1-5 (Group C, n = 102), or two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 (Group D, n = 86). The groups were retrospectively compared for toxicity and outcomes, and 11 additional factors were evaluated for outcomes. Results: No significant difference was observed among the groups regarding radiation-related acute oral mucositis and radiation-related late toxicities. Acute Grade 3 skin toxicity was significantly more frequent in Group B than in the patients of the other three groups (p = .013). The chemotherapy-related Grade 3 nausea/vomiting rate was 24% for Group A, 8% for Group B, 9% for Group C, and 6% for Group D (p = .003). The corresponding Grade 3 nephrotoxicity rates were 8%, 1%, 2%, and 1% (p = .019). The corresponding Grade 3-4 hematologic toxicity rates were 35%, 41%, 19%, and 21% (p = .027). Chemotherapy could be completed in 50%, 59%, 74%, and 83% of the Group A, B, C, and D patients, respectively (p = .002). Toxicity-related radiotherapy breaks occurred in 39%, 43%, 21%, and 15% of Groups A, B, C, and D, respectively (p = .005). The 3-year locoregional control rate was 67%, 72%, 60%, and 59% for Groups A, B, C, and D, respectively (p = .48). The corresponding 3-year metastasis-free survival rates were 67%, 74%, 63%, and 79% (p = .31), and the corresponding 3-year survival rates were 60%, 63%, 50%, and 71% (p = .056). On multivariate analysis, Karnofsky performance status, histologic grade, T/N category, preradiotherapy hemoglobin level

  5. When a Baby Dies.

    ERIC Educational Resources Information Center

    Church, Martha Jo; And Others

    Written especially for grieving mothers whose babies have died, this booklet offers an overview of stages and experiences through which bereaved parents commonly pass. Specifically, the text is intended to give comfort to bereaved parents, offer insight into the grieving process, and provide thoughts on leave-taking ceremonies. The first section…

  6. When Somebody Dies

    MedlinePlus

    ... to have fun with. That absence leaves a big hole in our lives. Maybe you had a pet that died . Remember the first few times you walked into the house after your dog or cat was gone? It was strange not to have ...

  7. Die Kosmologie der Griechen.

    NASA Astrophysics Data System (ADS)

    Mittelstraß, J.

    Contents: 1. Mythische Eier. 2. Thales-Welten. 3. "Alles ist voller Götter". 4. Griechische Astronomie. 5. "Rettung der Phänomene". 6. Aristotelische Kosmololgie. 7. Aristoteles-Welt und Platon-Welt. 8. Noch einmal: die Göttlichkeit der Welt. 9. Griechischer Idealismus.

  8. When Somebody Dies

    MedlinePlus

    ... A A What's in this article? When — and How — Does It Happen? Where Do Dead People Go? What Does Grieving Mean? What About Me? If I'm Going to Die Someday, What Should I Do Now? en español ...

  9. Schlüsselkomponenten für Roboter in der Produktion Roboterhaut und Sicherheitskonzept für die Mensch-Roboter Kooperation

    NASA Astrophysics Data System (ADS)

    Denkena, B.; Hesse, P.; Friederichs, J.; Wedler, A.

    Vorgestellt wird der Aufbau einer aktiven Sensor-Matrix zur Abstands- und Kontaktdetektion in der Robotik. Diese besteht aus einem Sensornetzwerk zur Fusion und Überlagerung differenter physikalischer Wirkprinzipien. Die Sicherheit der I2C-Bus Kommunikation, der Aufbau der Roboterhaut, Ergebnisse der Abstandsdetektion mit Infrarot-, und Ultraschallsensorik werden dargestellt. Ferner wurden Temperatur-, und Beschleunigungssensoren auf die Oberfläche der Roboterhaut aufgebracht um Informationen über die Umgebung sicher an ein übergeordnetes Leitsystem zu übertragen. Eine unterlagerte sichere Roboterhaut mit Kontaktdetektion zeigt als einfache Schlüsselkomponente ein analoges Ausschaltverhalten für geringe Latenzzeiten. Als Schluss wird auf den Einsatz an einem Industrieroboter in der Produktion ohne trennende Schutzeinrichtungen (OTS) eingegangen.

  10. Evolutionäre Algorithmen zur Topologieentwicklung von Neuronalen Netzen für die Roboter-Navigation im praktischen Einsatz

    NASA Astrophysics Data System (ADS)

    Köpsel, T.; Noglik, A.; Pauli, J.

    Eine wichtige Frage in der mobilen Robotik ist die sichere Navigation in unbekannten Umgebungen unter der Anwendung preiswerter Sensorik. Solch eine Navigation kann ein künstliches Neuronales Netz (kNN) übernehmen, welches die Kopplung der Sensoren des Roboters mit dessen Antriebssystem herstellt. "Neuro Evolution of Augmenting Topologies“ (NEAT) von Stanley und Miikkulainen [1] verwendet den Evolutionären Ansatz sowohl für die Topologieentwicklung, als auch für die Bestimmung der Gewichte eines kNN. NEAT hat sich als sehr gut, anpassungsfähig und relativ einfach in der Anwendung gezeigt. In diesem Beitrag wird NEAT in der Simulation angewendet, um ein kNN, das die Navigation des Roboters übernimmt, zu erhalten. Der Fokus liegt dabei auf der Erstellung der Fitnessfunktion und die Spezifikation und Durchführung einer realitätstreuen Simulation für den praktischen Einsatz. Die enge Verknüpfung von Realität und Simulationswelt hat entscheidend dazu beigetragen, dass der Umstieg aus der Simulation in die reale Welt ein Erfolg (höhere Anpassungsfähigkeit) wird. Dieser Artikel basiert auf der Diplomarbeit von [2].

  11. High-Grade Acute Organ Toxicity as a Positive Prognostic Factor in Primary Radiochemotherapy for Anal Carcinoma

    SciTech Connect

    Wolff, Hendrik Andreas; Raus, Ismene; Jung, Klaus; Schueler, Phillip; Herrmann, Markus Karl; Hennies, Steffen; Vorwerk, Hilke; Hille, Andrea; Hess, Clemens Friedrich; Christiansen, Hans

    2011-04-01

    Purpose: To test for a possible correlation between high-grade acute organ toxicity during primary radiochemotherapy and treatment outcome for patients with anal carcinoma. Methods and Materials: From 1991 to 2009, 72 patients with anal carcinoma were treated at our department (10 patients had stage I, 28 patients had stage II, 11 patients had stage IIIA, and 13 patients had stage IIIB cancer [Union Internationale Contre le Cancer criteria]). All patients received normofractionated (1.8 Gy/day, five times/week) whole-pelvis irradiation including iliac and inguinal lymph nodes with a cumulative dose of 50.4 Gy. Concomitant chemotherapy regimen consisted of two cycles of 5-fluorouracil (1,000 mg/m{sup 2}total body surface area (TBSA)/day as continuous intravenous infusion on days 1-4 and 29-32) and mitomycin C (10 mg/m{sup 2}/TBSA, intravenously on days 1 and 29). Toxicity during treatment was monitored weekly, and any incidence of Common Toxicity Criteria (CTC) grade of {>=}3 for skin reaction, cystitis, proctitis, or enteritis was assessed as high-grade acute organ toxicity for later analysis. Results: We found significant correlation between high-grade acute organ toxicity and overall survival, locoregional control, and stoma-free survival, which was independent in multivariate analysis from other possible prognostic factors: patients with a CTC acute organ toxicity grade of {>=}3 had a 5-year overall survival rate of 97% compared to 30% in patients without (p < 0.01, multivariate analysis; 97% vs. 48%, p = 0.03 for locoregional control, and 95% vs. 59%, p = 0.05 for stoma-free survival). Conclusions: Our data indicate that normal tissue and tumor tissue may behave similarly with respect to treatment response, since high-grade acute organ toxicity during radiochemotherapy showed itself to be an independent prognostic marker in our patient population. This hypothesis should be further analyzed by using biomolecular and clinical levels in future clinical trials.

  12. Die Deutsche Statistische Gesellschaft in der Weimarer Republik und während der Nazidiktatur

    NASA Astrophysics Data System (ADS)

    Wilke, Jürgen

    Nach anfänglichen Schwierigkeiten durch den 1. Weltkrieg erlangte die Deutsche Statistische Gesellschaft (DStatG) unter dem renommierten Statistiker und Vorsitzenden der DStatG, Friedrich Zahn, durch eine Vielzahl von Aktivitäten hohes Ansehen. Es gab Bestrebungen, Statistiker aus allen Arbeitsfeldern der Statistik in die DStatG zu integrieren, wobei die "Mathematische Statistik" nur zögerlich akzeptiert wurde (Konjunkturforschung, Zeitreihenanalyse). Nach der Machtübernahme 1933 durch Adolf Hitler geriet die DStatG in das Fahrwasser nationalsozialistischer Ideologie und Politik (Führerprinzip, Gleichschaltung des Vereinswesens). Damit war eine personelle Umstrukturierung in der DStatG verbunden. Politisch Missliebige und rassisch Verfolgte mussten die DStatG verlassen (Bernstein, Freudenberg, Gumbel u.a.). Unter den Statistikern gab es alle Abstufungen im Verhalten zum Regime von Ablehnung und zwangsweiser Anpassung über bereitwilliges Mitläufertum bis zu bewusster Täterschaft. Besonders die Bevölkerungsstatistik wurde durch die NS- Rassenpolitik auf lange Sicht diskreditiert. Im Rahmen von Wirtschaftsplanung und Aufrüstung wurden neue zukunftsträchtige statistische Modelle (Grünig, Bramstedt, Leisse) entwickelt.

  13. Modeling the Mechanical Performance of Die Casting Dies

    SciTech Connect

    R. Allen Miller

    2004-02-27

    The following report covers work performed at Ohio State on modeling the mechanical performance of dies. The focus of the project was development and particularly verification of finite element techniques used to model and predict displacements and stresses in die casting dies. The work entails a major case study performed with and industrial partner on a production die and laboratory experiments performed at Ohio State.

  14. Involvement of RNA binding proteins AUF1 in mammary gland differentiation

    SciTech Connect

    Nagaoka, Kentaro . E-mail: akenaga@mail.ecc.u-tokyo.ac.jp; Tanaka, Tetsuya; Imakawa, Kazuhiko; Sakai, Senkiti

    2007-08-01

    The expression of many genes, such as {beta}-casein, c-myc, and cyclin D1, is altered by lactogenic hormone stimulation during mammary epithelial cell differentiation. Here, we demonstrate that post-transcriptional regulation plays an important role to establish gene expression required to initiate milk production as well as transcriptional control. AUF1 protein, a member of the AU-rich element (ARE)-binding protein family, plays a role in ARE-mRNA turnover by regulating mRNA stability and/or translational control. Cytoplasmic localization of AUF1 protein is critically linked to function. We show that as the mammary gland differentiates, AUF1 protein moves from the cytoplasm to the nucleus. Moreover, in mammary gland epithelial cells (HC11), stimulation by lactogenic hormone decreased cytoplasmic and increased nuclear AUF1 levels. Direct binding of AUF1 protein was observed on c-myc mRNA, but not {beta}-casein or cyclin D1 mRNA. AUF1 downregulation in HC11 cells increased the expression of {beta}-casein mRNA and decreased the expression of c-myc mRNA by lactogenic hormone. Conversely, overexpression of AUF1 inhibited these effects of lactogenic hormone stimulation in HC11 cells. These results suggest that AUF1 participates in mammary gland differentiation processes under the control of lactogenic hormone signals.

  15. Die kalte Zunge

    NASA Astrophysics Data System (ADS)

    Bartels, Sören; Müller, Rüdiger

    Gefühlte Temperaturen. Ist ein Null Grad Celsius kalter Metallstab eigentlich kälter als ein Holzstab mit der selben Temperatur? Rein physikalisch gesehen natürlich nicht, aber wenn wir beide Stäbe anfassen, kommt uns der Metallstab deutlich kälter vor. Und wer kennt nicht die Szene aus dem Film Dumm und Dümmer in der Harry mit seiner Zunge am Metallrahmen des Skilifts hängen bleibt.Würde das auch passieren, wenn man an einem eiskalten Stück Holz lecken würde? Wohl kaum, doch woran liegt das eigentlich? Unterschiedliche Materialien haben verschiedene Fähigkeiten, Wärme zu übertragen und zu leiten. So transportiert Metall die von der Zunge ausgehende Wärme sehr schnell weiter und verändert seine Temperatur kaum, während die Zunge abkühlt. Holz hingegen leitet Wärme fast gar nicht und daher wird der Teil, der von der Zunge berührt wird, aufgewärmt.

  16. Heated die facilitates tungsten forming

    NASA Technical Reports Server (NTRS)

    Chattin, J. H.; Haystrick, J. E.; Laughlin, J. C.; Leidy, R. A.

    1966-01-01

    Tungsten forming in a press brake employs a bottom die assembly with a heating manifold between two water-cooled die sections. The manifold has hydrogen-oxygen burners spaced along its length for even heat during forming.

  17. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  18. SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy

    PubMed Central

    Storaci, Alessandra Maria; Annovazzi, Laura; Cassoni, Paola; Melcarne, Antonio; De Blasio, Pasquale; Schiffer, Davide; Biunno, Ida

    2015-01-01

    The suppressor of Lin-12-like (C. elegans) (SEL1L) is involved in the endoplasmic reticulum (ER)-associated degradation pathway, malignant transformation and stem cells. In 412 formalin-fixed and paraffin-embedded brain tumors and 39 Glioblastoma multiforme (GBM) cell lines, we determined the frequency of five SEL1L single nucleotide genetic variants with regulatory and coding functions by a SNaPShot™ assay. We tested their possible association with brain tumor risk, prognosis and therapy. We studied the in vitro cytotoxicity of valproic acid (VPA), temozolomide (TMZ), doxorubicin (DOX) and paclitaxel (PTX), alone or in combination, on 11 GBM cell lines, with respect to the SNP rs12435998 genotype. The SNP rs12435998 was prevalent in anaplastic and malignant gliomas, and in meningiomas of all histologic grades, but unrelated to brain tumor risks. In GBM patients, the SNP rs12435998 was associated with prolonged overall survival (OS) and better response to TMZ-based radio-chemotherapy. GBM stem cells with this SNP showed lower levels of SEL1L expression and enhanced sensitivity to VPA. PMID:25948789

  19. Tolerability of piperacillin/tazobactam in children and adolescents after high dose radio-/chemotherapy and autologous stem cell transplantation.

    PubMed

    Nürnberger, W; Bönig, H; Burdach, S; Göbel, U

    1998-01-01

    The combination of piperacillin with tazobactam (PIP/TAZ) extends the activity of piperacillin against gram-positive, gram-negative, and anaerobic bacteria. The broad-spectrum of this formulation, together with its low degree of organ toxicity observed in adults, makes PIP/TAZ a tempting choice for children with radio-/chemotherapy-induced neutropenia. However, the use of PIP/TAZ is not yet approved for children under 12 years of age. The tolerability of PIP/TAZ was assessed in 19 children and adolescents between 2 and 18 years of age who developed a fever during aplasia after high dose radio-/chemotherapy and autologous stem cell transplantation (HD-SCT) for primary multifocal or relapsed solid tumours. Treatment with PIP/TAZ was initiated on average 3 days after HD-SCT, and the treatment was continued for approximately 10 days. Both clinical observation and laboratory studies showed no relevant alterations that would have been attributable to PIP/TAZ treatment. These results indicate that PIP/TAZ appears to be well tolerated in children during the acute phase of HD-SCT.

  20. High-dose-rate intraluminal brachytherapy prior to external radiochemotherapy in locally advanced esophageal cancer: preliminary results

    PubMed Central

    Safaei, Afsaneh Maddah; Ghalehtaki, Reza; Khanjani, Nezhat; Farazmand, Borna; Babaei, Mohammad

    2017-01-01

    Purpose Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance. To induce fast relief of dysphagia in patients with potentially operable esophageal cancer high-dose-rate (HDR) brachytherapy was applied prior to definitive radiochemotherapy. Material and methods In this single arm phase II clinical trial between 2013 to 2014 twenty patients with locally advanced esophageal cancer (17 squamous cell and 3 adenocarcinoma) were treated with upfront 10 Gy HDR brachytherapy, followed by 50.4 Gy external beam radiotherapy (EBRT) and concurrent chemotherapy with cisplatin/5-fluorouracil. Results Tumor response, as measured by endoscopy and/or computed tomography scan, revealed complete remission in 16 and partial response in 4 patients (overall response rate 100%). Improvement of dysphagia was induced by brachytherapy within a few days and maintained up to the end of treatment in 80% of patients. No differences in either response rate or dysphagia resolution were found between squamous cell and adenocarcinoma histology. The grade 2 and 3 acute pancytopenia or bicytopenia reported in 4 patients, while sub-acute adverse effects with painful ulceration was seen in five patients, occurring after a median of 2 months. A perforation developed in one patient during the procedure of brachytherapy that resolved successfully with immediate surgery. Conclusions Brachytherapy before EBRT was a safe and effective procedure to induce rapid and durable relief from dysphagia, especially when combined with EBRT. PMID:28344601

  1. Brain Stem and Entire Spinal Leptomeningeal Dissemination of Supratentorial Glioblastoma Multiforme in a Patient during Postoperative Radiochemotherapy

    PubMed Central

    Kong, Xiangyi; Wang, Yu; Liu, Shuai; Chen, Keyin; Zhou, Qiangyi; Yan, Chengrui; He, Huayu; Gao, Jun; Guan, Jian; Yang, Yi; Li, Yongning; Xing, Bing; Wang, Renzhi; Ma, Wenbin

    2015-01-01

    Abstract Glioblastoma multiforme (GBM) is the most common primary malignancy of the central nervous system in adults. Macroscopically evident and symptomatic spinal metastases occur rarely. Autopsy series suggest that approximately 25% of patients with intracranial GBM have evidence of spinal subarachnoid seeding, although the exact incidence is not known as postmortem examination of the spine is not routinely performed.1–3 Herein, we present a rare case of symptomatic brain stem and entire spinal dissemination of GBM in a 36-year-old patient during postoperative adjuvant radiochemotherapy with temozolomide and cisplatin. Visual deterioration, intractable stomachache, and limb paralysis were the main clinical features. The results of cytological and immunohistochemical tests on the cerebrospinal fluid cells were highly suggestive of spinal leptomeningeal dissemination. After 1 month, the patient's overall condition deteriorated and succumbed to his disease. To the best of our knowledge, this is the first reported case of GBM dissemination presenting in this manner. Because GBM extracranial dissemination is rare, we also reviewed pertinent literature regarding this uncommon entity. Although metastases to spinal cord from GBM are uncommon, it is always important to have in mind when patients with a history of GBM present with symptoms that do not correlate with the primary disease pattern. PMID:26091464

  2. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy

    PubMed Central

    Schultheis, Anne M.; Nguyen, Gia Phuong; Ortmann, Monika; Kruis, Wolfgang; Büttner, Reinhard; Schildhaus, Hans-Ulrich; Markiefka, Birgid

    2014-01-01

    Primary squamous cell carcinoma of the pancreas is a rare malignant neoplasia, accounting for approximately 0.5–2% of all malignant pancreatic tumors. These lesions are characterized by poor prognosis. Here we report on a case of a 57-year-old female patient with known BRCA2 germline mutation presenting with primary squamous cell carcinoma of the pancreas as the only malignancy. The tumor was locally advanced at the first presentation but responded almost completely to neoadjuvant radio-chemotherapy. Our case highlights the facts (i) that pancreatic carcinomas belong to the tumor spectrum of patients with the BRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) and (ii) that tumors of the pancreas can represent the first or even the only manifestation of HBOC. Furthermore, this case of a nonkeratinizing squamous cell carcinoma indicates that HBOC-associated carcinomas of the pancreas might be characterized by a broader morphological spectrum than was previously thought. Since BRCA mutations cause deficiency of DNA double-strand breakage repair in tumors, neoadjuvant treatment regimens might become a reasonable option in HBOC-associated pancreatic carcinomas. To our knowledge, this is the first reported case of a primary pancreatic squamous cell carcinoma in a patient with this particular genetic background of BRCA2-associated HBOC. PMID:24959366

  3. Designing a Die for Hydroforming

    NASA Astrophysics Data System (ADS)

    Vasile, Radu

    2016-12-01

    Designing a die is in every application field an intensive process of bringing together know how from design, testing and every-day use from previous dies with the new application requirements. Contribution deals with a knowledge oriented, modular and feature integrated computer aided design system for die development. This paper describes the concepts behind designing a hydroforming die for sheet metal forming, with easy application-use in small workshops for testing hydroforming capabilities of different materials.

  4. Dying with dignity.

    PubMed

    Madan, T N

    1992-08-01

    Death is a theme of central importance in all cultures, but the manner in which it is interpreted varies from society to society. Even so, traditional cultures, including Christian, Hindu and Jain religious traditions, exhibited a positive attitude to death and did not look upon it in a dualistic framework of good vs bad, or desirable vs undesirable. Nor was pessimism the dominant mood in their thinking about death itself. A fundamental paradigm shift occurred in the West in the eighteenth century when death was desacralized and transformed into a secular event amenable to human manipulation. From those early beginnings, dying and death have been thoroughly medicalized and brought under the purview of high technology in the twentieth century. Once death is seen as a problem for professional management, the hospital displaces the home, and specialists with different kinds and degrees of expertise take over from the family. Everyday speech and the religious idiom yield place to medical jargon. The subject (an ageing, sick or dying person) becomes the object of this make-believe yet real world. As the object of others' professional control, he or she loses the freedom of self-assessment, expression and choice. Or, he or she may be expected to choose when no longer able to do so. Thus, not only freedom but dignity also is lost, and lawyers join doctors in crisis manipulation and perpetuation. Although the modern medical culture has originated in the West, it has gradually spread to all parts of the world, subjugating other kinds of medical knowledge and other attitudes to dying and death.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Assessment of the Radiation-Equivalent of Chemotherapy Contributions in 1-Phase Radio-chemotherapy Treatment of Muscle-Invasive Bladder Cancer

    SciTech Connect

    Plataniotis, George A.; Dale, Roger G.

    2014-03-15

    Purpose: To estimate the radiation equivalent of the chemotherapy contribution to observed complete response rates in published results of 1-phase radio-chemotherapy of muscle-invasive bladder cancer. Methods and Materials: A standard logistic dose–response curve was fitted to data from radiation therapy-alone trials and then used as the platform from which to quantify the chemotherapy contribution in 1-phase radio-chemotherapy trials. Two possible mechanisms of chemotherapy effect were assumed (1) a fixed radiation-independent contribution to local control; or (2) a fixed degree of chemotherapy-induced radiosensitization. A combination of both mechanisms was also considered. Results: The respective best-fit values of the independent chemotherapy-induced complete response (CCR) and radiosensitization (s) coefficients were 0.40 (95% confidence interval −0.07 to 0.87) and 1.30 (95% confidence interval 0.86-1.70). Independent chemotherapy effect was slightly favored by the analysis, and the derived CCR value was consistent with reports of pathologic complete response rates seen in neoadjuvant chemotherapy-alone treatments of muscle-invasive bladder cancer. The radiation equivalent of the CCR was 36.3 Gy. Conclusion: Although the data points in the analyzed radio-chemotherapy studies are widely dispersed (largely on account of the diverse range of chemotherapy schedules used), it is nonetheless possible to fit plausible-looking response curves. The methodology used here is based on a standard technique for analyzing dose-response in radiation therapy-alone studies and is capable of application to other mixed-modality treatment combinations involving radiation therapy.

  6. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells.

    PubMed

    Ishii, Takashi; Hayakawa, Hiroshi; Sekiguchi, Takeshi; Adachi, Noritaka; Sekiguchi, Mutsuo

    2015-02-01

    In aerobically growing cells, in which reactive oxygen species are produced, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine, which induces alterations in gene expression. Here we show that the human Auf1 protein, also called HNRNPD, binds specifically to RNA containing this oxidized base and may be involved in cellular processes associated with managing the problems caused by RNA oxidation. Auf1-deficient cells were constructed from human HeLa and Nalm-6 lines using two different targeting procedures. Both types of Auf1-deficient cells are viable, but exhibit growth retardation. The stability of messenger RNA for four different housekeeping genes was determined in Auf1-deficient and -proficient cells, treated with or without hydrogen peroxide. The level of oxidized messenger RNA was considerably higher in Auf1-deficient cells than in Auf1-proficient cells. Auf1 may play a role in the elimination of oxidized RNA, which is required for the maintenance of proper gene expression under conditions of oxidative stress.

  7. Die Behandlung des Wilden Westerns auf der Mittelstufe (Treatment of the Wild West in the Intermediate Grades).

    ERIC Educational Resources Information Center

    Omasreiter, Ria

    1979-01-01

    Presents a 2- to 3-hour teaching unit dealing with conflict between Whites and Indians, taking as an example the Black Hawk War. The reports of Chief Black Hawk and of historian Billington (sources for both are given) are taken as a basis for discussion. (IFS/WGA)

  8. Auf gute Nachbarschaft!. Verantwortungsübernahme durch Unternehmen für die Stadtteilentwicklung - Haniel und Grillo in Duisburg

    NASA Astrophysics Data System (ADS)

    Kleine-König, Christiane; Hohn, Uta

    2016-03-01

    Companies' community involvement turns out to be spatially relevant and-in many cases-to be focused on the near surroundings of the place of business. Some companies strategically align their involvement in order to systematically address local challenges. The essay at hand addresses the subject of corporate social responsibility from a local development perspective. Using the example of two family-owned enterprises based in Duisburg, Haniel and Grillo, it illustrates how socially committed companies can get involved with their local community by acting as good neighbours. Furthermore, it argues that socially committed companies can function as producers of space concerning matters of urban and local development. The specific local settings as well as the economic conditions of the local community serve as an explanatory background of the companies' involvement. The cases presented in this paper prove the firms' specific knowledge of local development needs and possibilities. This makes them qualified partners for local government actors and civil society actors. Thus, in the future, it is worth addressing corporate local responsibility from a governance point of view both in theory and in practice.

  9. Die Titicaca-See-Region auf dem Altiplano von Peru und Bolivien und die Folgen eingeführter Fische für Wildarten und ihren Lebensraum

    NASA Astrophysics Data System (ADS)

    Villwock, Wolfgang

    1993-01-01

    In the course of a long-term case study (since 1960) the interaction between different exotic fish (salmonids, atherinids) on the endemic ichthyofauna (genus Orestias: Cyprinodontidae) introduced to the interandean basin of Lake Titicaca was observed. The contribution deals not only with the actual consequences which endanger endemic species but also the socio-economic effects on the native Indian population, both causing further ecological problems in the region of concern.

  10. Accurate defect die placement and nuisance defect reduction for reticle die-to-die inspections

    NASA Astrophysics Data System (ADS)

    Wen, Vincent; Huang, L. R.; Lin, C. J.; Tseng, Y. N.; Huang, W. H.; Tuo, Laurent C.; Wylie, Mark; Chen, Ellison; Wang, Elvik; Glasser, Joshua; Kelkar, Amrish; Wu, David

    2015-10-01

    Die-to-die reticle inspections are among the simplest and most sensitive reticle inspections because of the use of an identical-design neighboring-die for the reference image. However, this inspection mode can have two key disadvantages: (1) The location of the defect is indeterminate because it is unclear to the inspector whether the test or reference image is defective; and (2) nuisance and false defects from mask manufacturing noise and tool optical variation can limit the usable sensitivity. The use of a new sequencing approach for a die-to-die inspection can resolve these issues without any additional scan time, without sacrifice in sensitivity requirement, and with a manageable increase in computation load. In this paper we explore another approach for die-to-die inspections using a new method of defect processing and sequencing. Utilizing die-to-die double arbitration during defect detection has been proven through extensive testing to generate accurate placement of the defect in the correct die to ensure efficient defect disposition at the AIMS step. The use of this method maintained the required inspection sensitivity for mask quality as verified with programmed-defectmask qualification and then further validated with production masks comparing the current inspection approach to the new method. Furthermore, this approach can significantly reduce the total number of defects that need to be reviewed by essentially eliminating the nuisance and false defects that can result from a die-to-die inspection. This "double-win" will significantly reduce the effort in classifying a die-to-die inspection result and will lead to improved cycle times.

  11. Modification of loco-regional microenvironment in brain tumors by spinal cord stimulation. Implications for radio-chemotherapy.

    PubMed

    Clavo, B; Robaina, F; Valcarcel, B; Catala, L; Perez, J L; Cabezon, A; Jorge, I J; Fiuza, D; Hernandez, M A; Jover, R; Carreras, J L

    2012-01-01

    The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral arteries (MCA) and (2) in common carotid arteries (CCA); (3) tumor blood-flow using single photon emission computed tomography (SPECT); (4) tumor-pO(2) (mmHg) using polarographic probes (eight tumor areas from five patients); and (5) tumor glucose metabolism using (18)F-fluoro-2-deoxyglucose ((18)FDG) positron emission tomography ((18)FDG-PET). Pre-SCS: tumor blood-flow was lower (P < 0.001) than peri-tumor areas and healthy contra-lateral areas. Tumor-pO(2) was lower (P < 0.042) than healthy tissue. Tumor glucose metabolism was higher than peri-tumor areas (P = 0.017) and healthy contra-lateral areas (P = 0.048). Post-SCS: there were increases in: MCA blood-flow (P ≤ 0.002), CCA blood-flow (P ≤ 0.013), tumor blood-flow (P = 0.033), tumor glucose metabolism (P = 0.027) and tumor-pO(2) (P = 0.022). The percentage of hypoxic values decreased (P = 0.007). SCS can modify tumor micro-environment. The potential usefulness of SCS in improving the effectiveness of radio-chemotherapy in HGG needs to be evaluated.

  12. Prognostic Value of Early [{sup 18}F]Fluoroethyltyrosine Positron Emission Tomography After Radiochemotherapy in Glioblastoma Multiforme

    SciTech Connect

    Piroth, Marc D.; Pinkawa, Michael; Holy, Richard; Klotz, Jens; Nussen, Sandra; Stoffels, Gabriele; Coenen, Heinz H.; Kaiser, Hans J.; Langen, Karl J.; Eble, Michael J.

    2011-05-01

    Purpose: Early detection of treatment response in glioma patients after radiochemotherapy (RCX) is uncertain because treatment-related contrast enhancement in magnetic resonance imaging can mimic tumor progression. Positron emission tomography (PET) using the amino acid tracer [{sup 18}F]fluoroethyltyrosine (FET) seems to be a promising tool for treatment monitoring. The aim of this prospective study was to evaluate the prognostic value of early changes of FET uptake after postoperative RCX in glioblastomas. Methods and Materials: Twenty-two patients with glioblastoma were treated by surgery and subsequent RCX (whole dose 60-72 Gy). The FET-PET studies were performed before RCX, 7-10 days and 6-8 weeks after completion of RCX. Early treatment response in PET was defined as a decrease of the maximal tumor-to-brain ratio (TBR{sub max}) of FET uptake after RCX of more than 10%. The prognostic value of early changes of FET uptake after RCX was evaluated using Kaplan-Maier estimates for median disease-free survival and overall survival. Results: The median overall and disease-free survival of the patients was 14.8 and 7.8 months. There were 16 early responders in FET-PET (72.7%) and 6 nonresponders (27.3%). Early PET responders had a significantly longer median disease-free survival (10.3 vs. 5.8 months; p < 0.01) and overall survival ('not reached' vs. 9.3 months; p < 0.001). No statistically significant differences between the patient subgroups were found concerning the defined prognostic parameters. Conclusions: FET-PET is a sensitive tool to predict treatment response in patients with glioblastomas at an early stage after RCX.

  13. Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy or Radiochemotherapy: Prognostic Role of TP53 and HPV Status

    SciTech Connect

    Fallai, Carlo; Perrone, Federica; Licitra, Lisa; Pilotti, Silvana; Locati, Laura; Bossi, Paolo; Orlandi, Ester; Palazzi, Mauro; Olmi, Patrizia

    2009-11-15

    Purpose: To study the prognostic value of the TP53 mutation and human papilloma virus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC). Methods and materials: The TP53 mutation and HPV status were analyzed in 78 cases of locoregionally advanced OPSCC. The possible correlation of these factors with locoregiownal control, relapse-free survival, disease-specific survival, and overall survival (OS) was also investigated. Results: Of these 78 cases, 22 had disruptive and 22 had non-disruptive (silent) TP53 mutations; the remaining 34 cases had wild-type (WT) TP53. HPV 16 DNA was found in 9 cases (11%), but all HPV-positive (HPV+) cases carried a functional p53 protein, except for 1 case that had a silent mutation. HPV+ patients fared better than HPV-negative (HPV-) patients in terms of all survival parameters, with highly statistically significant differences between the groups. Specifically, no distant metastases were observed in the HPV+ patients, whereas they occurred in 17% of the HPV- patients. However, no difference was observed between the WT TP53 and mutation group, even when this was analyzed in terms of disruptive and non-disruptive mutations. Regardless, treatment with chemotherapy nearly doubled the 5-year OS rates, both in the mutation (42% vs. 22%) and WT (30 vs. 16%) group, but only the mutation group showed improvement in all survival parameters. In addition, the second tumor-free 5-year survival rate was 72% in HPV- cases, but no second tumors were observed in HPV+ and WT p53 cases. Conclusions: Patients with HPV+ OPSCC have an excellent prognosis after radiochemotherapy, but cisplatin-based chemotherapy may not confer a satisfactory outcome, especially in WT cases, thereby justifying the additional or alternative use of taxanes and epidermal growth factor receptors inhibitors. Uncommon distant metastases and second tumors in the HPV+ group may be cause for clinicians to review the follow-up policies in these patients.

  14. Toxicity of concurrent radiochemotherapy for locally advanced non--small-cell lung cancer: a systematic review of the literature.

    PubMed

    Koning, Caro C; Wouterse, Sanne J; Daams, Joost G; Uitterhoeve, Lon L; van den Heuvel, Michel M; Belderbos, José S

    2013-09-01

    Concurrent radiochemotherapy (RCT) is the treatment of choice for patients with locally advanced non-small-cell lung cancer (NSCLC). Two meta-analyses were inconclusive in an attempt to define the optimal concurrent RCT scheme. Besides efficacy, treatment toxicity will influence the appointed treatment of choice. A systematic review of the literature was performed to record the early and late toxicities, as well as overall survival, of concurrent RCT regimens in patients with NSCLC. The databases of PubMed, Ovid, Medline, and the Cochrane Library were searched for articles on concurrent RCT published between January 1992 and December 2009. Publications of phase II and phase III trials with ≥ 50 patients per treatment arm were selected. Patient characteristics, chemotherapy regimen (mono- or polychemotherapy, high or low dose) and radiotherapy scheme, acute and late toxicity, and overall survival data were compared. Seventeen articles were selected: 12 studies with cisplatin-containing regimens and 5 studies using carboplatin. A total of 13 series with mono- or polychemotherapy schedules--as single dose or double or triple high-dose or daily cisplatin-containing (≤ 30 mg/m(2)/wk) chemotherapy were found. Acute esophagitis ≥ grade 3 was observed in up to 18% of the patients. High-dose cisplatin regimens resulted in more frequent and severe hematologic toxicity, nausea, and vomiting than did other schemes. The toxicity profile was more favorable in low-dose chemotherapy schedules. From phase II and III trials published between 1992 and 2010, it can be concluded that concurrent RCT with monochemotherapy consisting of daily cisplatin results in favorable acute and late toxicity compared with concurrent RCT with single high-dose chemotherapy, doublets, or triplets.

  15. Stage II/III rectal cancer with intermediate response to preoperative radiochemotherapy: Do we have indications for individual risk stratification?

    PubMed Central

    2010-01-01

    Background Response to preoperative radiochemotherapy (RCT) in patients with locally advanced rectal cancer is very heterogeneous. Pathologic complete response (pCR) is accompanied by a favorable outcome. However, most patients show incomplete response. The aim of this investigation was to find indications for risk stratification in the group of intermediate responders to RCT. Methods From a prospective database of 496 patients with rectal adenocarcinoma, 107 patients with stage II/III cancers and intermediate response to preoperative 5-FU based RCT (ypT2/3 and TRG 2/3), treated within the German Rectal Cancer Trials were studied. Surgical treatment comprised curative (R0) total mesorectal excision (TME) in all cases. In 95 patients available for statistical analyses, residual transmural infiltration of the mesorectal compartment, nodal involvement and histolologic tumor grading were investigated for their prognostic impact on disease-free (DFS) and overall survival (OS). Results Residual tumor transgression into the mesorectal compartment (ypT3) did not influence DFS and OS rates (p = 0.619, p = 0.602, respectively). Nodal involvement after preoperative RCT (ypN1/2) turned out to be a valid prognostic factor with decreased DFS and OS (p = 0.0463, p = 0.0236, respectively). Persistent tumor infiltration of the mesorectum (ypT3) and histologic tumor grading of residual tumor cell clusters were strongly correlated with lymph node metastases after neoadjuvant treatment (p < 0.001). Conclusions Advanced transmural tumor invasion after RCT does not affect prognosis when curative (R0) resection is achievable. Residual nodal status is the most important predictor of individual outcome in intermediate responders to preoperative RCT. Furthermore, ypT stage and tumor grading turn out to be additional auxiliary factors. Future clinical trials for risk-adapted adjuvant therapy should be based on a synopsis of clinicopathologic parameters. PMID:20388220

  16. Influence of Irradiated Lung Volumes on Perioperative Morbidity and Mortality in Patients After Neoadjuvant Radiochemotherapy for Esophageal Cancer

    SciTech Connect

    Daehn, Doreen; Martell, Joachim; Vorwerk, Hilke; Hess, Clemens F.; Becker, Heinz; Jung, Klaus; Hilgers, Reinhard; Wolff, Hendrik Andreas; Hermann, Robert Michael; Christiansen, Hans

    2010-05-01

    Purpose: In some randomized trials, the treatment outcome of locally advanced esophageal cancer has been significantly improved by neoadjuvant radiochemotherapy (RCT). However, increased perioperative pulmonary toxicity in terms of acute respiratory distress syndrome (ARDS) has been linked to radiation exposure of the lungs. In our study we evaluated perioperative morbidity and mortality in patients with cancer Stages IIA-IVA treated with curative intent either with surgery alone (S) or with neoadjuvant RCT followed by surgery (RCTS). Patients and Methods: Between 1996 and 2003, 55 patients received S, and 98 received RCTS. In the RCTS group, most patients received two cycles of 5-fluorouracil plus cisplatinum simultaneously with normofractionated radiotherapy (40Gy). Four weeks later they underwent surgery. Endpoints were the incidence of acute lung injury (ALI), ARDS, other postoperative complications, and mortality within 31 days. Results: Between both groups there were no significant differences between the incidence and severity of ALI and ARDS (RCTS: 42.9%, 42.9%; S: 45.5%, 38.2%). Furthermore, there were no significant differences in the incidences of pneumonia, pleural effusion, and pneumothorax (RCTS 29.6% vs. S 16.4%, p = 0.07). Perioperative complication rates and mortality did not vary significantly (mortality after RCTS 5.1% vs. S 3.6%). A detailed analysis of 54 RCTS patients according to lung dose-volume histograms did not show any correlation between ARDS and pulmonary exposure. In univariate analysis, only respiratory comorbidity correlated with ARDS. Conclusion: Neoadjuvant cisplatinum and 5-fluorouracil-based RCT apparently has no detrimental impact on the postoperative course.

  17. Where people die.

    PubMed Central

    Katz, B P; Zdeb, M S; Therriault, G D

    1979-01-01

    Death certificates for 1977 filed with the New York State Department of Health were studied to determine where people died. Data were examined by the location and cause of death and by the age, sex, race, and marital status of the decedent. Comparisons were made with a similar study in which U.S. data were used for 1958 events. Approximately 60 percent of all the 1977 deaths in upstate New York occurred in hospitals; only 27 percent occurred outside an institution. The location of death varied by all the factors studied. Within all age categories, males had a higher percentage of hospital deaths. In those age categories in which nursing home deaths comprised a significant proportion of total deaths, females had a higher percentage of such deaths than males. Differences in the location of death according to its cause reflect the nature of the cause of death, for example, whether it was of sudden onset or the result of chronic disease. Most people do not consider in advance where they might die. The idea that age, sex, and marital status, as well as the more obvious cause, all play a part in the location may seem surprising. Yet all these factors were found to be associated withe location of deaths in upstate New York, and there is no reason to believe that this association does not hold true for the entire nation. More research, however, needs to be done based on more years and other geographic artal stutus may be instructive as to the present state of health resources. PMID:515338

  18. Maintaining Low Voiding Solder Die Attach for Power Die While Minimizing Die Tilt

    SciTech Connect

    Hamm, Randy; Peterson, Kenneth A.

    2015-10-01

    This paper addresses work to minimize voiding and die tilt in solder attachment of a large power die, measuring 9.0 mm X 6.5 mm X 0.1 mm (0.354” x 0.256” x 0.004”), to a heat spreader. As demands for larger high power die continue, minimizing voiding and die tilt is of interest for improved die functionality, yield, manufacturability, and reliability. High-power die generate considerable heat, which is important to dissipate effectively through control of voiding under high thermal load areas of the die while maintaining a consistent bondline (minimizing die tilt). Voiding was measured using acoustic imaging and die tilt was measured using two different optical measurement systems. 80Au-20Sn solder reflow was achieved using a batch vacuum solder system with optimized fixturing. Minimizing die tilt proved to be the more difficult of the two product requirements to meet. Process development variables included tooling, weight and solder preform thickness.

  19. Graphite/Thermoplastic-Pultrusion Die

    NASA Technical Reports Server (NTRS)

    Wilson, Maywood L.; Frye, Mark W.; Johnson, Gary S.; Stanfield, Clarence E.

    1990-01-01

    Attachment to extruder produces thermoplastic-impregnated graphite tape. Consists of profile die, fiber/resin collimator, and crosshead die body. Die designed to be attached to commercially available extrusion machine capable of extruding high-performance thermoplastics. Simple attachment to commercial extruder enables developers of composites to begin experimenting with large numbers of proprietary resins, fibers, and hybrid composite structures. With device, almost any possible fiber/resin combination fabricated.

  20. Die Milchstraße.

    NASA Astrophysics Data System (ADS)

    Henbest, N.; Couper, H.

    This book is a German translation, by M. Röser, from the English original "The guide to the Galaxy", published in 1994 (see Abstr. 61.003.065). Contents: 1. Die Entdeckung unserer Galaxis. 2. Die Lokale Gruppe. 3. Die Geographie der Galaxis. 4. Der Perseus-Arm. 5. Der Orion-Arm. 6. Unsere lokale Nachbarschaft: ein typischer Winkel der Galaxis. 7. Der Sagittarius-Arm: innerhalb der Sonnenumlaufbahn. 8. Das Zentrum der Galaxis.

  1. Role of Dynamic Magnetic Resonance Imaging in the Evaluation of Tumor Response to Preoperative Concurrent Radiochemotherapy for Large Breast Cancers: A Prospective Phase II Study

    SciTech Connect

    Bollet, Marc A. Thibault, Fabienne; Bouillon, Kim; Meunier, Martine; Sigal-Zafrani, Brigitte; Savignoni, Alexia; Dieras, Veronique; Nos, Claude; Salmon, Remy; Fourquet, Alain

    2007-09-01

    Purpose: To evaluate the accuracy of clinical examination and of three imaging modalities (ultrasound [US] scan, mammography, and magnetic resonance imaging [MRI]) to assess the tumor response of breast cancer to a preoperative regimen of concurrent radiochemotherapy for large breast cancers, using pathologic data as the reference. Methods and Materials: Sixty women were accrued. Treatment consisted of 4 cycles of (5-fluorouracil-vinorelbine) chemotherapy with, starting with the second cycle of chemotherapy, locoregional radiotherapy to the breast and the internal mammary and supraclavicular and infraclavicular lymph nodes. Breast surgery and axillary lymph node dissection were subsequently performed. Breast imaging assessments were performed both before chemotherapy and preoperatively. Results: The correlation coefficients between tumor dimension at imaging and pathology were statistically significant for US scan (r = 0.4; p = 0.006) and MRI (r = 0.4; p = 0.004) but not for clinical examination (r 0.2; p = 0.16) or mammography (r = -0.15; p = 0.31). Furthermore, the area under the receiver operating characteristic curve for MRI was 0.81, compared with 0.67 for US scan. At the optimal threshold score, MRI performed with 81% sensitivity and 75% specificity. Conclusion: Compared with clinical examination, US scan, or mammography, MRI substantially improved the prediction of pathologic tumor response to preoperative concurrent radiochemotherapy for large breast cancers.

  2. Association between XRCC1 and ERCC1 single-nucleotide polymorphisms and the efficacy of concurrent radiochemotherapy in patients with esophageal squamous cell carcinoma.

    PubMed

    Huang, Xue; Liu, Changmin; Cui, Yayun; Zhang, Heping; Liu, Yongping; Zhou, Xifa; Luo, Judong

    2017-02-01

    The aim of the present study was to investigate the association between single-nucleotide polymorphisms (SNPs) in X-ray repair cross-complementing 1-399 (XRCC1-399) or excision repair cross-complementation group 1-118 (ERCC1-118) and the short-term efficacy of radiochemotherapy, tumor metastasis and relapse, as well as the survival time in patients with esophageal squamous cell carcinoma (ESCC). TaqMan probe-based quantitative polymerase chain reaction (qPCR) was conducted to examine the levels of XRCC1-399 and ERCC1-118 SNPs in the peripheral blood of 50 patients with pathologically confirmed ESCC. In addition, the associations between different genotypes and short-term therapeutic efficacy [the complete remission (CR) rate], tumor metastasis and relapse, as well as the survival time following concurrent radiochemotherapy, were determined. A total of 50 ESCC patients who received concurrent radiochemotherapy were enrolled. It was found that the short-term therapeutic efficacy (CR rate) was higher in the group of patients carrying the homozygous mutation of XRCC1-399 (A/A genotype) than in the group of patients without the XRCC1-399 mutation (G/G genotype). In addition, the CR rate was significantly increased in patients carrying one or two ERCC1-118 C alleles (C/C or C/T genotype) compared with patients lacking the C allele (T/T genotype). The differences were statistically significant (A/A vs. G/G, P=0.014; TT vs. C/T+C/C, P=0.040). During the follow-up period, the group of patients carrying the homozygous mutation of XRCC1-399 (A/A genotype) exhibited a markedly reduced risk of metastasis and relapse compared with the group of patients carrying non-mutated XRCC1-399 (G/G genotype; P=0.031). By contrast, ERCC1-118 SNP was not associated with the risk of metastasis and recurrence (P>0.05). The combined results of univariate and multivariate Cox regression analysis showed that the SNP in ERCC1-118 was closely associated with survival time. The mean survival time

  3. Association between XRCC1 and ERCC1 single-nucleotide polymorphisms and the efficacy of concurrent radiochemotherapy in patients with esophageal squamous cell carcinoma

    PubMed Central

    Huang, Xue; Liu, Changmin; Cui, Yayun; Zhang, Heping; Liu, Yongping; Zhou, Xifa; Luo, Judong

    2017-01-01

    The aim of the present study was to investigate the association between single-nucleotide polymorphisms (SNPs) in X-ray repair cross-complementing 1–399 (XRCC1-399) or excision repair cross-complementation group 1–118 (ERCC1-118) and the short-term efficacy of radiochemotherapy, tumor metastasis and relapse, as well as the survival time in patients with esophageal squamous cell carcinoma (ESCC). TaqMan probe-based quantitative polymerase chain reaction (qPCR) was conducted to examine the levels of XRCC1-399 and ERCC1-118 SNPs in the peripheral blood of 50 patients with pathologically confirmed ESCC. In addition, the associations between different genotypes and short-term therapeutic efficacy [the complete remission (CR) rate], tumor metastasis and relapse, as well as the survival time following concurrent radiochemotherapy, were determined. A total of 50 ESCC patients who received concurrent radiochemotherapy were enrolled. It was found that the short-term therapeutic efficacy (CR rate) was higher in the group of patients carrying the homozygous mutation of XRCC1-399 (A/A genotype) than in the group of patients without the XRCC1-399 mutation (G/G genotype). In addition, the CR rate was significantly increased in patients carrying one or two ERCC1-118 C alleles (C/C or C/T genotype) compared with patients lacking the C allele (T/T genotype). The differences were statistically significant (A/A vs. G/G, P=0.014; TT vs. C/T+C/C, P=0.040). During the follow-up period, the group of patients carrying the homozygous mutation of XRCC1-399 (A/A genotype) exhibited a markedly reduced risk of metastasis and relapse compared with the group of patients carrying non-mutated XRCC1-399 (G/G genotype; P=0.031). By contrast, ERCC1-118 SNP was not associated with the risk of metastasis and recurrence (P>0.05). The combined results of univariate and multivariate Cox regression analysis showed that the SNP in ERCC1-118 was closely associated with survival time. The mean survival

  4. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.

    PubMed

    Liao, Baisong; Hu, Yan; Brewer, Gary

    2007-06-01

    (A+U)-rich elements (AREs) within 3' untranslated regions are signals for rapid degradation of messenger RNAs encoding many oncoproteins and cytokines. The ARE-binding protein AUF1 contributes to their degradation. We identified MYC proto-oncogene mRNA as a cellular AUF1 target. Levels of MYC translation and cell proliferation were proportional to AUF1 abundance but inversely proportional to the abundance of the ARE-binding protein TIAR, a MYC translational suppressor. Both AUF1 and TIAR affected MYC translation via the ARE without affecting mRNA abundance. Altering association of one ARE-binding protein with MYC mRNA in vivo reciprocally affected mRNA association with the other protein. Finally, genetic experiments revealed that AUF1 and TIAR control proliferation by a MYC-dependent pathway. Together, these observations suggest a novel regulatory mechanism where tuning the ratios of AUF1 and TIAR bound to MYC mRNA permits dynamic control of MYC translation and cell proliferation.

  5. I Could Have Died Laughing.

    ERIC Educational Resources Information Center

    Maher, Michael Forrest; Smith, Douglas

    1993-01-01

    Notes that caregivers of the dying would do well to consider the prescriptive power of humor when confronting the challenges of healthy care for the terminally ill. Addresses laughter as the best medicine not only for the dying person but also for family and principal caregivers. Includes examples of therapeutic use of humor with the terminally…

  6. Adapt or die?

    PubMed

    Visser, S S; Nel, A H

    1996-12-01

    The worldwide economic recession and the concomitant limited stock of finances have had an influence on the available money of every household and have also inhibited the improvement of socio-economic conditions and medicine. The Reconstruction and Development Programme (RDP) has the objective of improving the living conditions of the people with regard to housing, education, training and health care. The latter seems to be a major problem which has to be addressed with the emphasis on the preventive and promotional aspects of health care. A comprehensive health care system did not come into being property in the past because of the maldistribution of health care services, personnel and differences in culture and health care beliefs and values. The question that now arises, is how to render a quality health care service within the constraints of inadequate financing and resources. A comprehensive literature study has been done with reference to quality health care and financing followed by a survey of existing health services and finances. Recommendations are made about minimum requirements to be accepted if one were to adapt rather than die in terms of the provision of healthcare: the decentralization and rationalization of the administration of health care, the stress on and realization of effective and efficient primary health care, the acceptance of participative management in health providing organizations, the provision of financial management training for health care managers and the application of management accounting principles for the improvement of the efficiency and effectiveness of management.

  7. Two Piece Compaction Die Design

    SciTech Connect

    Coffey, Ethan N

    2010-03-01

    Compaction dies used to create europium oxide and tantalum control plates were modeled using ANSYS 11.0. Two-piece designs were considered in order to make the dies easier to assemble than the five-piece dies that were previously used. The two areas of concern were the stresses at the interior corner of the die cavity and the distortion of the cavity wall due to the interference fit between the two pieces and the pressure exerted on the die during the compaction process. A successful die design would have stresses less than the yield stress of the material and a maximum wall distortion on the order of 0.0001 in. Design factors that were investigated include the inner corner radius, the value of the interference fit, the compaction force, the size of the cavity, and the outer radius and geometry of the outer ring. The results show that for the europium oxide die, a 0.01 in. diameter wire can be used to create the cavity, leading to a 0.0055 in. radius corner, if the radial interference fit is 0.003 in. For the tantalum die, the same wire can be used with a radial interference fit of 0.001 in. Also, for the europium oxide die with a 0.003 in. interference fit, it is possible to use a wire with a diameter of 0.006 in. for the wire burning process. Adding a 10% safety factor to the compaction force tends to lead to conservative estimates of the stresses but not for the wall distortion. However, when the 10% safety factor is removed, the wall distortion is not affected enough to discard the design. Finally, regarding the europium oxide die, when the cavity walls are increased by 0.002 in. per side or the outer ring is made to the same geometry as the tantalum die, all the stresses and wall distortions are within the desired range. Thus, the recommendation is to use a 0.006 in. diameter wire and a 0.003 in. interference fit for the europium oxide die and a 0.01 in. diameter wire and a 0.001 in. interference fit for the tantalum die. The dies can also be made to have the

  8. Coupling between magnetic and optical properties of stable Au-Fe solid solution nanoparticles

    NASA Astrophysics Data System (ADS)

    de Julián Fernández, C.; Mattei, G.; Paz, E.; Novak, R. L.; Cavigli, L.; Bogani, L.; Palomares, F. J.; Mazzoldi, P.; Caneschi, A.

    2010-04-01

    Au-Fe nanoparticles constitute one of the simplest prototypes of a multifunctional nanomaterial that can exhibit both magnetic and optical (plasmonic) properties. This solid solution, not feasible in the bulk phase diagram in thermal equilibrium, can be formed as a nanostructure by out-of-equilibrium processes. Here, the novel magnetic, optical and magneto-optical properties of ion-implanted Au-Fe solid solution nanoparticles dispersed in a SiO2 matrix are investigated and correlated. The surface plasmon resonance of the Au-Fe nanoparticles with almost equicomposition is strongly damped when compared to pure Au and to Au-rich Au-Fe nanoparticles. In all cases, the Au atoms are magnetically polarized, as measured by x-ray magnetic circular dichroism, and ferromagnetically coupled with Fe atoms. Although the chemical stability of Au-Fe nanoparticles is larger than that of Fe nanoparticles, both the magnetic moment per Fe atom and the order temperature are smaller. These results suggest that electronic and magnetic properties are more influenced by the hybridization of the electronic bands in the Au-Fe solid solution than by size effects. On the other hand, the magneto-optical transitions allowed in the vis-nIR spectral regions are very similar. In addition, we also observe, after studying the properties of thermally treated samples, that the Au-Fe alloy is stabilized, not by surface effects, but by the combination of the out-of-equilibrium nature of the ion implantation technique and by changes in the properties due to size effects.

  9. Dying: A universal human experience?

    PubMed

    Bregman, L

    1989-03-01

    This paper explores the question, "Is there a universal psychological experience suffered by all dying persons?" a question to which the popular theory of Kübler-Ross presupposes an affirmative answer. Our answer takes three steps: first, a comparison between the Kübler-Ross model of dying and that of the late medievalBook of the Craft of Dying centered upon the five Kübler-Ross "stages"; second, a philosophical critique of the terms of this comparison; and third, a revised look at the alleged similarities between the two models, providing a deeper look at the moral and spiritual assumptions behind each.

  10. Reduction of AUF1-mediated follistatin mRNA decay during glucose starvation protects cells from apoptosis.

    PubMed

    Gao, Xiangwei; Dong, Haojie; Lin, Chen; Sheng, Jinghao; Zhang, Fan; Su, Jinfeng; Xu, Zhengping

    2014-01-01

    Follistatin (FST) performs several vital functions in the cells, including protection from apoptosis during stress. The expression of FST is up-regulated in response to glucose deprivation by an unknown mechanism. We herein showed that the induction of FST by glucose deprivation was due to an increase in the half-life of its mRNA. We further identified an AU-rich element (ARE) in the 3'UTR of FST mRNA that mediated its decay. The expression of FST was elevated after knocking down AUF1 and reduced when AUF1 was further expressed. In vitro binding assays and RNA pull-down assays revealed that AUF1 interacted with FST mRNA directly via its ARE. During glucose deprivation, a majority of AUF1 shuttled from cytoplasm to nucleus, resulting in dissociation of AUF1 from FST mRNA and thus stabilization of FST mRNA. Finally, knockdown of AUF1 decreased whereas overexpression of AUF1 increased glucose deprivation-induced apoptosis. The apoptosis promoting effect of AUF1 was eliminated in FST expressing cells. Collectively, this study provided evidence that AUF1 is a negative regulator of FST expression and participates in the regulation of cell survival under glucose deprivation.

  11. REFRACTORY DIE FOR EXTRUDING URANIUM

    DOEpatents

    Creutz, E.C.

    1959-08-11

    A die is presented for the extrusion of metals, said die being formed of a refractory complex oxide having the composition M/sub n/O/sub m/R/sub x/O/sub y/ where M is magnesium, zinc, manganese, or iron, R is aluminum, chromic chromium, ferric iron, or manganic manganese, and m, n, x, and y are whole numbers. Specific examples are spinel, magnesium aluminate, magnetite, magnesioferrite, chromite, and franklinite.

  12. HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

    SciTech Connect

    Xu Ting; Wei Qingyi; Lopez Guerra, Jose Luis; Gomez, Daniel; O'Reilly, Michael; Lin, Steven Hsesheng; Zhuang Yan; Levy, Lawrence B.; Mohan, Radhe; Zhou Honghao; Liao Zhongxing

    2012-10-01

    Purpose: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). Methods and Materials: Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped 2 SNPs of HSPB1 (NCBI SNP nos. rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. Results: Our cohort consisted of 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range, 63-87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than CG and GG genotypes (univariate hazard ratio [HR] = 1.39, 95% confidence interval [CI], 1.02-1.90; P=.037; multivariate HR = 1.39; 95% CI, 1.01-1.92; P=.045). Conclusions: Our results showed that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

  13. Dumbbell-like Au-Fe3O4 nanoparticles: a new nanostructure for supercapacitors.

    PubMed

    Liu, Sheng; Guo, Shaojun; Sun, Shouheng; You, Xiao-Zeng

    2015-03-21

    Monodispersed dumbbell-like Au-Fe3O4 nanoparticles (NPs) were synthesized and studied for use in supercapacitors. These dumbbell NPs show Au/Fe3O4-size dependent capacitive behaviors and the 7-14 nm Au-Fe3O4 NPs have the best specific capacitance of 464 F g(-1) at 1 A g(-1) and capacity retention of 86.4% after 1000 cycles, much larger than pure Fe3O4 NPs (160 F g(-1) and 72.8% retention). This capacitive enhancement is believed to arise from the Au-induced increase in electron transfer across the dumbbell-like NPs. Thise report demonstrates a new strategy to enhance oxide NP capacitance for applications in high performance supercapacitors.

  14. Melker Meilensteine auf dem Weg in ein naturwissenschaftliches Zeitalter - Glanzlichter der Ausstellung zum Internationalen Astronomiejahr 2009 in der Melker Stiftsbibliothek.

    NASA Astrophysics Data System (ADS)

    Beck, Paul G.; Zotti, Georg

    2009-06-01

    Das Mittelalter wird weithin als die dunkle Epoche in der Geschichte der Europäischen Wissenschaften betrachtet, und insbesondere das Leben in den Klöstern galt lange Zeit als frei von jeglichem Interesse für Naturwissenschaften abseits der Medizin. Im Mittelalter galt die Astronomie bloß als Mittel zum Zweck, um religiöse und zivile Kalender erstellen zu können. Durch den Bestand der Handschriftenkammer der Melker Stiftsbibliothek eröffnet sich uns eine neue Sichtweise auf das gegen Ende des Mittelalters wachsende Interesse an den Naturwissenschaften. Dies wurde durch die starke Aufwertung der Klosterbibliothek im Rahmen der 'Melker Reform' im 15. Jahrhundert noch weiter verstärkt. Diese Epoche fällt mit der Frühphase der Universität Wien und der 'ersten Wiener Schule der Astronomie' zusammen. Dieser Artikel beleuchtet ausgewählte astronomischen Werke in der Melker Stiftsbibliothek zwischen dem frühen 9 und dem 18. Jahrhundert. Einen Schwerpunkt stellt das Wirken der Wiener Schule der Astronomie dar, wobei wir u.a. die Melker Abschrift von Peuerbachs Gutachten über den Kometen von 1456 sowie die im Stift Melk durchgeführte Beobachtung der Mondfinsternis von 1457 durch Regiomontanus und Peuerbach beleuchten. Dieser Beitrag ist der einführende Übersichtsartikel zum Ausstellungsprojekt in der Melker Stiftsbibliothek im Rahmen des Internationalen Jahres der Astronomie 2009. The medieval period is commonly seen as a dark epoch for science in Europe. Especially monasteries were seen as institutions without interest in natural sciences except for medicine. Astronomy was allegedly only a tool to construct religious and civil calendars. The inventory of the medieval manuscript collection of the library of the Abbey of Melk allows a new view on the growing interest in the exact sciences towards the end of the medieval ages. This interest was intensified through the increased importance of the monastery library due to the monastery reform

  15. Spin glass transition in canonical AuFe alloys: A numerical study

    NASA Astrophysics Data System (ADS)

    Zhang, Kai-Cheng; Li, Yong-Feng; Liu, Gui-Bin; Zhu, Yan

    2012-05-01

    Although spin glass transitions have long been observed in diluted magnetic alloys, e.g. AuFe and CuMn alloys, previous numerical studies are not completely consistent with the experiment results. The abnormal critical exponents of the alloys remain still puzzling. By employing parallel tempering algorithm with finite-size scaling analysis, we investigated the phase transitions in canonical AuFe alloys. Our results strongly support that spin glass transitions occur at finite temperatures in the alloys. The calculated critical exponents agree well with those obtained from experiments.

  16. Clinical management of dying patients.

    PubMed Central

    Gavrin, J; Chapman, C R

    1995-01-01

    Dying is universal, and death should be a peaceful time. Myriad comfort measures are available in the last weeks before life ends. Discussions about end-of-life issues often suffer from lack of informed opinion. Palliative care experts have identified specific somatic and psychological sources of distress for dying patients and their loved ones. Pain, shortness of breath, nausea and vomiting, and fear of abandonment contribute substantially to both physical and psychological discomfort toward the end of life. Simple, effective methods exist for relieving those symptoms. Knowledge about the natural events associated with dying and an informed approach to medical and psychological interventions contribute to systematic and successful comfort care. We describe the origin of physical and psychological distress at the end of life and provide strategies for alleviating many of the discomforts. PMID:7571591

  17. [Dying with cancer: Hollywood lessons].

    PubMed

    Niemeyer, Fernanda; Kruse, Maria Henriqueta Luce

    2013-12-01

    The study attempts to understand how dying from cancer is portrayed by five movies produced in Hollywood between 1993 and 2006. Based on the cultural studies and their post-structuralism version and supported by the notions of discourse and subjectivity, as proposed by philosopher Michel Foucault, we suggest one of the possible readings of the movie picture corpus. We assess how the movie picture discourse acts as a cultural pedagogy that produces ways of seeing dying with cancer: immortalizing the healthy body image, silencing death, taking care of the dead body and, finally, accepting death. Our proposal is intended to stimulate reflections that may contribute to care and education in nursing.

  18. Portable punch and die jig

    DOEpatents

    Lewandowski, Edward F.; Anderson, Petrus A.

    1978-01-01

    A portable punch and die jig includes a U-shaped jig of predetermined width having a slot of predetermined width in the base thereof extending completely across the width of the jig adapted to fit over the walls of rectangular tubes and a punch and die assembly disposed in a hole extending through the base of the jig communicating with the slot in the base of the jig for punching a hole in the walls of the rectangular tubes at precisely determined locations.

  19. Die Herz-Lungen-Maschine

    NASA Astrophysics Data System (ADS)

    Krane, Markus; Bauernschmitt, Robert; Lange, Rüdiger

    Das Kapitel der modernen Herzchirurgie mit Einsatz der Herz-Lungen-Maschine am Menschen beginnt am 6. Mai 1953, als J. Gibbon bei einer 18-jährigen Patientin einen angeborenen Defekt in der Vorhofscheidewand verschließt [1]. Mit ersten experimentellen Versuchen zur extrakorporalen Zirkulation begann Gibbon bereits in den 30er Jahren des 20. Jahrhunderts. Die Grundlage für die heute gebräuchliche Rollerpumpe schufen Porter und Bradley mit ihrer "rotary pump“, welche sie 1855 zum Patent anmeldeten. Diese Pumpe wurde von DeBakey und Schmidt modifiziert und entspricht im Wesentlichen noch der heute sich im Routinebetrieb befindlichen Rollerpumpe [2].

  20. Attitudes on Death and Dying.

    ERIC Educational Resources Information Center

    Andrus, Charles E.

    This paper explored attitudes toward death and dying revealed through interviews with members of the clergy, the medical profession, funeral directors, nursing home residents, and selected others. The sampling was small and results are not intended to be representative of the groups to which these people belong. Rather, the study may be used as a…

  1. Robert Merton Dies at 92

    ERIC Educational Resources Information Center

    Snell, Joel C.

    2006-01-01

    This article features Robert Merton, who died recently at age 92. Merton came into this world as a Jewish baby named Meyer Schkolnick. He lived in South Philly where his parents wrenched a living as blue-collar workers. Merton chose an Anglicized name to move into the Yankee dominated America of the 20's and 30's. At Harvard, he studied under…

  2. Superparamagnetic Au-Fe3O4 nanoparticles: one-pot synthesis, biofunctionalization and toxicity evaluation

    NASA Astrophysics Data System (ADS)

    Pariti, A.; Desai, P.; Maddirala, S. K. Y.; Ercal, N.; Katti, K. V.; Liang, X.; Nath, M.

    2014-09-01

    Superparamagnetic Au-Fe3O4 bifunctional nanoparticles have been synthesized using a single step hot-injection precipitation method. The synthesis involved using Fe(CO)5 as iron precursor and HAuCl4 as gold precursor in the presence of oleylamine and oleic acid. Oleylamine helps in reducing Au3+ to Au0 seeds which simultaneously oxidizes Fe(0) to form Au-Fe3O4 bifunctional nanoparticles. Triton® X-100 was employed as a highly viscous solvent to prevent agglomeration of Fe3O4 nanoparticles. Detailed characterization of these nanoparticles was performed by using x-ray powder diffraction, transmission electron microscopy, scanning tunneling electron microscopy, UV-visible spectroscopy, Mössbauer and magnetometry studies. To evaluate these nanoparticles’ applicability in biomedical applications, L-cysteine was attached to the Au-Fe3O4 nanoparticles and cytotoxicity of Au-Fe3O4 nanoparticles was tested using CHO cells by employing MTS assay. L-cysteine modified Au-Fe3O4 nanoparticles were qualitatively characterized using Fourier transform infrared spectroscopy and Raman spectroscopy; and quantitatively using acid ninhydrin assay. Investigations reveal that that this approach yields Au-Fe3O4 bifunctional nanoparticles with an average particle size of 80 nm. Mössbauer studies indicated the presence of Fe in Fe3+ in A and B sites (tetrahedral and octahedral, respectively) and Fe2+ in B sites (octahedral). Magnetic measurements also indicated that these nanoparticles were superparamagnetic in nature due to Fe3O4 region. The saturation magnetization for the bifunctional nanoparticles was observed to be ˜74 emu g-1, which is significantly higher than the previously reported Fe3O4 nanoparticles. Mössbauer studies indicated that there was no significant Fe(0) impurity that could be responsible for the superparamagnetic nature of these nanoparticles. None of the investigations showed any presence of other impurities such as Fe2O3 and FeOOH. These Au-Fe3O4 bifunctional

  3. The thermal fatigue resistance of H-13 Die Steel for aluminum die casting dies

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The effects of welding, five selected surface coatings, and stress relieving on the thermal fatigue resistance of H-13 Die Steel for aluminum die casting dies were studied using eleven thermal fatigue specimens. Stress relieving was conducted after each 5,000 cycle interval at 1050 F for three hours. Four thermal fatigue specimens were welded with H-13 or maraging steel welding rods at ambient and elevated temperatures and subsequently, subjected to different post-weld heat treatments. Crack patterns were examined at 5,000, 10,000, and 15,000 cycles. The thermal fatigue resistance is expressed by two crack parameters which are the average maximum crack and the average cracked area. The results indicate that a significant improvement in thermal fatigue resistance over the control was obtained from the stress-relieving treatment. Small improvements were obtained from the H-13 welded specimens and from a salt bath nitrogen and carbon-surface treatment. The other surface treatments and welded specimens either did not affect or had a detrimental influence on the thermal fatigue properties of the H-13 die steel.

  4. Technische Systeme für den Herzersatz und die Herzunterstützung

    NASA Astrophysics Data System (ADS)

    Schöb, Reto; Loree, Howard M.

    Herzkrankheiten verursachen allein in den Vereinigten Staaten jährlich mehr als 700’000 Todesfälle. Ungefähr 3 Millionen Patienten in den U.S.A. leiden gemäss der American Heart Association (AHA) und dem National Heart, Lung and Blood Institute (NHLBI) an kongestivem Herzversagen (Congestive Heart Failure, CHF), welches eine chronische, sehr entkräftende und degenerative Krankheit ist: Das Herz ist dabei unfähig, hinreichend Blut zu den Organen des Körpers zu pumpen. Über 400’000 Fälle von CHF werden jedes Jahr diagnostiziert. Ähnliche Zahlen werden für Europa und Japan zusammen geschätzt. Basierend auf Daten vom AHA und NHLBI beträgt die fünfjährige Überlebensrate für CHF-Patienten lediglich etwa 50% [1]. 70’000-120’000 dieser Patienten könnten von einer Herzverpflanzung profitieren. 1999 wurden in den USA aber nur 2185 Herztransplantationen durchgeführt während die Warteliste über 4000 Patienten beträgt [2]. Ein akuter Mangel an Spenderherzen und die enormen Kosten (250’000-400’000 USD pro Patient) sind die begrenzenden Faktoren für Herztransplantationen [3]. Dies bedeutet, dass eine riesige Anzahl von Patienten durch ein zuverlässiges und verschleissfreies, nichtthrombotisches, total implantierbares, künstliches Herz gerettet werden könnten. Bis heute jedoch kein derartiges Implantat kommerziell verfügbar.

  5. Should assisted dying be legalised?

    PubMed

    Frost, Thomas D G; Sinha, Devan; Gilbert, Barnabas J

    2014-01-15

    When an individual facing intractable pain is given an estimate of a few months to live, does hastening death become a viable and legitimate alternative for willing patients? Has the time come for physicians to do away with the traditional notion of healthcare as maintaining or improving physical and mental health, and instead accept their own limitations by facilitating death when requested? The Universities of Oxford and Cambridge held the 2013 Varsity Medical Debate on the motion "This House Would Legalise Assisted Dying". This article summarises the key arguments developed over the course of the debate. We will explore how assisted dying can affect both the patient and doctor; the nature of consent and limits of autonomy; the effects on society; the viability of a proposed model; and, perhaps most importantly, the potential need for the practice within our current medico-legal framework.

  6. Guide for extrusion dies eliminates straightening operation

    NASA Technical Reports Server (NTRS)

    Gyorgak, C. A.; Hoover, R. J.

    1964-01-01

    To prevent distortion of extruded metal, a guidance assembly is aligned with the die. As the metal emerges from the extrusion dies, it passes directly into the receiver and straightening tube system, and the completed extrusion is withdrawn.

  7. Das Blüte-Bestäuber-Netz auf Brachflächen : biozönologische Untersuchung zur Bedeutung von Brachen in einer intensiv genutzten Agrarlandschaft

    NASA Astrophysics Data System (ADS)

    Hahn, Robert

    2002-11-01

    In der vorliegenden Dissertation wird die Bedeutung von Brachen für Artenvielfalt und Stabilität von Blüte-Bestäuber-Nahrungsnetzen in agrarisch genutzten Landschaften anhand ausgewählter blütenbesuchender Insektengruppen (Syrphidae, Lepidoptera) untersucht. Die Freilandarbeiten fanden von 1998-2000 im Raum der Feldberger Seenlandschaft, Mecklenburg-Vorpommern, statt. Es werden die beiden Hauptnahrungsquellen Nektar und Pollen betrachtet, dabei fanden Untersuchungen zur Intensität der Blüte-Bestäuber-Interaktion auf Stilllegungsflächen, zum flächenbezogenen quantitativen Nektarangebot im Jahresverlauf, zur individuellen Pollennutzung bei Syrphiden und zur Breite und Überlappung der Nahrungsnischen bei den dominanten Arten Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens und Sphaerophoria scripta statt. Im Ergebnis zeigt sich eine hohe Bedeutung der Brachflächen für die Stabilität des Blüte-Bestäuber-Netzes, während die Diversität von anderen, eher landschaftsbezogenen Faktoren abhängig ist. This dissertation examines the importance of fallow land for the diversity and stability of pollination webs in agricultural landscapes as exemplified by selected groups of anthophilous insects (syrphidae and lepidoptera). The field studies were carried out between 1998 and 2000 in the Feldberg lakeland area in the north-east German State of Mecklenburg-Western Pomerania. Observations were made of nectar and pollen as the two main sources of food. Studies were conducted into the intensity of plant-pollinator interaction in set-aside areas, the site-specific quantity of nectar available during the vegetation period and the individual pollen intake of syrphid flies. Different methods were employed to establish the breadth of the trophic niches among the predominant species (Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens and Sphaerophoria scripta) and the extent to which they overlapped. The studies showed that, while fallow land is very

  8. Contoured Orifice for Silicon-Ribbon Die

    NASA Technical Reports Server (NTRS)

    Mackintosh, B. H.

    1985-01-01

    Die configuration encourages purity and stable growth. Contour of die orifice changes near ribbon edges. As result, silicon ribbon has nearly constant width and little carbon contamination. Die part of furnace being developed to produce high-quality, low-cost material for solar cells.

  9. Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy.

    PubMed

    Schneider, Gabriela; Bryndza, Ewa; Abdel-Latif, Ahmed; Ratajczak, Janina; Maj, Magdalena; Tarnowski, Maciej; Klyachkin, Yuri M; Houghton, Peter; Morris, Andrew J; Vater, Axel; Klussmann, Sven; Kucia, Magdalena; Ratajczak, Mariusz Z

    2013-07-01

    Evidence suggests that bioactive lipids may regulate pathophysiologic functions such as cancer cell metastasis. Therefore, we determined that the bioactive lipid chemoattractants sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) strongly enhanced the in vitro motility and adhesion of human rhabdomyosarcoma (RMS) cells. Importantly, this effect was observed at physiologic concentrations for both bioactive lipids, which are present in biologic fluids, and were much stronger than the effects observed in response to known RMS prometastatic factors such as stromal derived factors-1 (SDF-1/CXCL12) or hepatocyte growth factor/scatter factor (HGF/SF). We also present novel evidence that the levels of S1P and C1P were increased in several organs after γ-irradiation or chemotherapy, which indicates an unwanted prometastatic environment related to treatment. Critically, we found that the metastasis of RMS cells in response to S1P can be effectively inhibited in vivo with the S1P-specific binder NOX-S93 that is based on a high-affinity Spiegelmer. These data indicate that bioactive lipids play a vital role in dissemination of RMS and contribute to the unwanted side effects of radio/chemotherapy by creating a prometastatic microenvironment.

  10. Induction of a Tumor-Metastasis-Receptive Microenvironment as an Unwanted Side Effect After Radio/Chemotherapy and In Vitro and In Vivo Assays to Study this Phenomenon.

    PubMed

    Schneider, Gabriela; Sellers, Zachariah Payne; Ratajczak, Mariusz Z

    2016-01-01

    Besides surgical removal of tumor tissue, chemotherapy and radiotherapy are the most important and efficient treatment modalities employed to treat therapy-susceptible malignancies. The main aim of this treatment-to destroy tumor cells-is unfortunately usually associated with toxicity to nontumor cells and different degrees of tissue and organ damage. In damaged tissues several chemoattractants are upregulated and released that may attract tumor cells. Moreover, highly migratory radio/chemotherapy treatment may endow cells with several properties of cancer stem cells which survive and respond to these chemoattractants upregulated in collateral tissues. Based on this, one of the unwanted and underappreciated side effects of chemotherapy or radiotherapy is the creation of a metastasis-receptive microenvironment in bones as well as in other organs of the body. Herein we describe methods and assays that can be employed to study migratory properties of cancer cells in in vitro (chemotaxis) and in vivo (seeding efficiency assay) conditions in response to the induction of pro-metastatic microenvironments in various organs and tissues.

  11. Survivin Expression as a Predictive Marker for Local Control in Patients With High-Risk T1 Bladder Cancer Treated With Transurethral Resection and Radiochemotherapy

    SciTech Connect

    Weiss, Christian; Krause, Steffen F.; Sauer, Rolf; Roedel, Claus; Roedel, Franz

    2009-08-01

    Purpose: The objectives of this study were to investigate the expression of survivin in tumor samples from patients with high-risk T1 bladder cancer and to correlate its expression with clinicopathologic features as well as clinical outcomes after initial transurethral resection (TURBT) followed by radiotherapy (RT) or radiochemotherapy (RCT). Methods and Materials: Survivin protein expression was evaluated by immunohistochemistry on tumor specimen (n = 48) from the initial TURBT, and was correlated with clinical and histopathologic characteristics as well as with 5-year rates of local failure, tumor progression, and death from urothelial cancer after primary bladder sparring treatment with RT/RCT. Results: Survivin was not expressed in normal bladder urothelium but was overexpressed in 67% of T1 tumors. No association between survivin expression and clinicopathologic factors (age, gender, grading, multifocality, associated carcinoma in situ) could be shown. With a median follow-up of 27 months (range, 3-140 months), elevated survivin expression was significantly associated with an increased probability of local failure after TURBT and RCT/RT (p = 0.003). There was also a clear trend toward a higher risk of tumor progression (p = 0.07) and lower disease-specific survival (p = 0.10). Conclusions: High survivin expression is a marker of tumor aggressiveness and may help to identify a subgroup of patients with T1 bladder cancer at a high risk for recurrence when treated with primary organ-sparing approaches such as TURBT and RCT.

  12. Exchange bias effect in Au-Fe3O4 nanocomposites

    NASA Astrophysics Data System (ADS)

    Chandra, Sayan; Frey Huls, N. A.; Phan, M. H.; Srinath, S.; Garcia, M. A.; Lee, Youngmin; Wang, Chao; Sun, Shouheng; Iglesias, Òscar; Srikanth, H.

    2014-02-01

    We report exchange bias (EB) effect in the Au-Fe3O4 composite nanoparticle system, where one or more Fe3O4 nanoparticles are attached to an Au seed particle forming ‘dimer’ and ‘cluster’ morphologies, with the clusters showing much stronger EB in comparison with the dimers. The EB effect develops due to the presence of stress at the Au-Fe3O4 interface which leads to the generation of highly disordered, anisotropic surface spins in the Fe3O4 particle. The EB effect is lost with the removal of the interfacial stress. Our atomistic Monte Carlo studies are in excellent agreement with the experimental results. These results show a new path towards tuning EB in nanostructures, namely controllably creating interfacial stress, and opens up the possibility of tuning the anisotropic properties of biocompatible nanoparticles via a controllable exchange coupling mechanism.

  13. Synthesis of monosized magnetic-optical AuFe alloy nanoparticles

    NASA Astrophysics Data System (ADS)

    Liu, Hong Ling; Wu, Jun Hua; Min, Ji Hyun; Kim, Young Keun

    2008-04-01

    We report the preparation and characterization of multifunctional AuFe alloy nanoparticles of three compositions, Au0.25Fe0.75, Au0.5Fe0.5, and Au0.75Fe0.25, by a polyol process. It is found that the fusion of the two elements into one nanostructure entity retains the optical and magnetic properties of the individual components. The x-ray diffraction and transmission electron microscopy analyses confirm the formation of the alloy nanostructure with a narrow distribution of particle sizes and provides the detailed structural arrangements. The magnetic investigation shows the superparamagnetic or soft ferromagnetic behavior of the nanoparticles at room temperature, whereas the UV-visible measurements display the variation of the absorption bands at ˜560nm. The AuFe nanoparticles are rendered water soluble after thiolation.

  14. Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe3O4 dumbbell nanoparticles

    NASA Astrophysics Data System (ADS)

    Shi, Wei; Liu, Xinyu; Wei, Chao; Xu, Zhichuan J.; Sim, Stanley Siong Wei; Liu, Linbo; Xu, Chenjie

    2015-10-01

    Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr05459a

  15. A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles.

    PubMed

    Landgraf, Lisa; Christner, Carolin; Storck, Wiebke; Schick, Isabel; Krumbein, Ines; Dähring, Heidi; Haedicke, Katja; Heinz-Herrmann, Karl; Teichgräber, Ulf; Reichenbach, Jürgen R; Tremel, Wolfgang; Tenzer, Stefan; Hilger, Ingrid

    2015-11-01

    Au@Fe3O4 Janus particles (JPs) are heteroparticles with discrete domains defined by different materials. Their tunable composition and morphology confer multimodal and versatile capabilities for use as contrast agents and drug carriers in future medicine. Au@Fe3O4 JPs have colloidal properties and surface characteristics leading to interactions with proteins in biological fluids. The resulting protein adsorption layer ("protein corona") critically affects their interaction with living matter. Although Au@Fe3O4 JPs displayed good biocompatibility in a standardized in vitro situation, an in-depth characterization of the protein corona is of prime importance to unravel underlying mechanisms affecting their pathophysiology and biodistribution in vitro and in vivo. Here, we comparatively analyzed the human plasma corona of Au-thiol@Fe3O4-SiO2-PEG JPs (NH2-functionalized and non-functionalized) and spherical magnetite (Fe3O4-SiO2-PEG) particles and investigated its effects on colloidal stability, biocompatibility and cellular uptake. Label-free quantitative proteomic analyses revealed that complex coronas including almost 180 different proteins were formed within only one minute. Remarkably, in contrast to spherical magnetite particles with surface NH2 groups, the Janus structure prevented aggregation and the adhesion of opsonins. This resulted in an enhanced biocompatibility of corona sheathed JPs compared to spherical magnetite particles and corona-free JPs.

  16. Evaluation of permanent die coatings to improve the wear resistance of die casting dies. Final project report, January 1, 1995--April 30, 1997

    SciTech Connect

    Shivpuri, R.

    1997-09-18

    Die Casting dies are subject to severe service conditions during the die casting operation. While these severe conditions are necessary to achieve high production rates, they cause the dies which are commonly made of H13 die steel, to suffer frequent failures. The major die failure mechanisms are erosion or washout, Heat checking, soldering and corrosion. Due to their geometrical complexity, die casting dies are very expensive (some dies cost over a million dollars), and thus a large number of parts have to be produced by a die, to justify this cost and leverage the advantages of the die casting process (high production rates, low manpower costs). A potential increase in the die service life, thus has a significant impact on the economics of the die; casting operation. There are many ways to extend die life: developing new wear resistant die materials, developing new surface treatments including coatings, improving heat treatment of existing H13 dies, using better lubricants that can protect the die material, or modifying the die geometry and process parameters to reduce the intensity of wear. Of these the use of coatings to improve the wear resistance of the die surface has shown a lot of promise. Consequently, use of coatings in the die casting industry and their wide use to decrease die wear can improve significantly the productivity of shop operations resulting in large savings in material and energy usage.

  17. Die singulation method and package formed thereby

    DOEpatents

    Anderson, Robert C [Tucson, AZ; Shul, Randy J [Albuquerque, NM; Clews, Peggy J [Tijeras, NM; Baker, Michael S [Albuquerque, NM; De Boer, Maarten P [Albuquerque, NM

    2012-08-07

    A method is disclosed for singulating die from a substrate having a sacrificial layer and one or more device layers, with a retainer being formed in the device layer(s) and anchored to the substrate. Deep Reactive Ion Etching (DRIE) etching of a trench through the substrate from the bottom side defines a shape for each die. A handle wafer is then attached to the bottom side of the substrate, and the sacrificial layer is etched to singulate the die and to form a frame from the retainer and the substrate. The frame and handle wafer, which retain the singulated die in place, can be attached together with a clamp or a clip and to form a package for the singulated die. One or more stops can be formed from the device layer(s) to limit a sliding motion of the singulated die.

  18. Vacuum die attach for integrated circuits

    DOEpatents

    Schmitt, E.H.; Tuckerman, D.B.

    1991-09-10

    A thin film eutectic bond for attaching an integrated circuit die to a circuit substrate is formed by coating at least one bonding surface on the die and substrate with an alloying metal, assembling the die and substrate under compression loading, and heating the assembly to an alloying temperature in a vacuum. A very thin bond, 10 microns or less, which is substantially void free, is produced. These bonds have high reliability, good heat and electrical conduction, and high temperature tolerance. The bonds are formed in a vacuum chamber, using a positioning and loading fixture to compression load the die, and an IR lamp or other heat source. For bonding a silicon die to a silicon substrate, a gold silicon alloy bond is used. Multiple dies can be bonded simultaneously. No scrubbing is required. 1 figure.

  19. Vacuum die attach for integrated circuits

    DOEpatents

    Schmitt, Edward H.; Tuckerman, David B.

    1991-01-01

    A thin film eutectic bond for attaching an integrated circuit die to a circuit substrate is formed by coating at least one bonding surface on the die and substrate with an alloying metal, assembling the die and substrate under compression loading, and heating the assembly to an alloying temperature in a vacuum. A very thin bond, 10 microns or less, which is substantially void free, is produced. These bonds have high reliability, good heat and electrical conduction, and high temperature tolerance. The bonds are formed in a vacuum chamber, using a positioning and loading fixture to compression load the die, and an IR lamp or other heat source. For bonding a silicon die to a silicon substrate, a gold silicon alloy bond is used. Multiple dies can be bonded simultaneously. No scrubbing is required.

  20. Potential of Adaptive Radiotherapy to Escalate the Radiation Dose in Combined Radiochemotherapy for Locally Advanced Non-Small Cell Lung Cancer

    SciTech Connect

    Guckenberger, Matthias; Wilbert, Juergen; Richter, Anne; Baier, Kurt; Flentje, Michael

    2011-03-01

    Purpose: To evaluate the potential of adaptive radiotherapy (ART) for advanced-stage non-small cell lung cancer (NSCLC) in terms of lung sparing and dose escalation. Methods and Materials: In 13 patients with locally advanced NSCLC, weekly CT images were acquired during radio- (n = 1) or radiochemotherapy (n = 12) for simulation of ART. Three-dimensional (3D) conformal treatment plans were generated: conventionally fractionated doses of 66 Gy were prescribed to the planning target volume without elective lymph node irradiation (Plan{sub 3}D). Using a surface-based algorithm of deformable image registration, accumulated doses were calculated in the CT images acquired during the treatment course (Plan{sub 4}D). Field sizes were adapted to tumor shrinkage once in week 3 or 5 and twice in weeks 3 and 5. Results: A continuous tumor regression of 1.2% per day resulted in a residual gross tumor volume (GTV) of 49% {+-} 15% after six weeks of treatment. No systematic differences between Plan{sub 3}D and Plan{sub 4}D were observed regarding doses to the GTV, lung, and spinal cord. Plan adaptation to tumor shrinkage resulted in significantly decreased lung doses without compromising GTV coverage: single-plan adaptation in Week 3 or 5 and twice-plan adaptation in Weeks 3 and 5 reduced the mean lung dose by 5.0% {+-} 4.4%, 5.6% {+-} 2.9% and 7.9% {+-} 4.8%, respectively. This lung sparing with twice ART allowed an iso-mean lung dose escalation of the GTV dose from 66.8 Gy {+-} 0.8 Gy to 73.6 Gy {+-} 3.8 Gy. Conclusions: Adaptation of radiotherapy to continuous tumor shrinkage during the treatment course reduced doses to the lung, allowed significant dose escalation and has the potential of increased local control.

  1. Treatment Outcomes of Locally Advanced Oropharyngeal Cancer: A Comparison Between Combined Modality Radio-Chemotherapy and Two Variants of Single Modality Altered Fractionation Radiotherapy

    SciTech Connect

    Kader, Hosam A.; Mydin, Aminudin R.; Wilson, Matthew; Alexander, Cheryl; Shahi, Jeevin; Pathak, Irvin; Wu, Jonn S.; Truong, Pauline T.

    2011-07-15

    Purpose: To compare outcomes in patients with locally advanced oropharyngeal cancer treated with radio-chemotherapy (RT-CT), accelerated fractionation radiotherapy (AccRT), or hypofractionated radiotherapy (HypoRT). Methods and Materials: Subjects were 321 consecutive patients with newly diagnosed oropharyngeal cancer, Stage III or IVA/B, treated between January 2001 and December 2005 at the BC Cancer Agency with RT-CT (n = 157), AccRT (n = 57), or HypoRT (n = 107). Outcomes examined were disease-specific survival (DSS), locoregional control (LRC), overall survival (OS), rate of G-tube use, and rate of hospitalization for acute complications. Results: Median follow-up was 3.4 years. Three-year Kaplan-Meier DSS with RT-CT, AccRT, and HypoRT were 80%, 81%, and 74%, respectively (p = 0.219). Cox regression analysis identified treatment modality as a significant factor affecting DSS (p = 0.038). Compared with RT-CT, the hazard ratio (HR) for DSS was 1.0 with AccRT and 2.0 with HypoRT (p = 0.021). Kaplan-Meier pairwise comparisons found no significant difference in LRC and OS between RT-CT and AccRT. HypoRT was associated with significantly lower LRC (p = 0.005) and OS (p = 0.008) compared with RT-CT. There were significant differences in the rates of G-tube use (p < 0.001) and of hospitalization (p = 0.036) among the three treatment groups, with the most frequent rates observed in the RT-CT group. Conclusions: In patients with locally advanced oropharyngeal cancer, AccRT conferred DSS, LRC, and OS comparable to that of RT-CT. Patients treated with RT-CT experienced higher rates of treatment-related acute toxicities. HypoRT was associated with the least favorable outcomes.

  2. How well do elderly patients with cervical cancer tolerate definitive radiochemotherapy using RapidArc? Results from an institutional audit comparing elderly versus younger patients

    PubMed Central

    Chakraborty, Santam; Geetha, M; Dessai, Sampada; Patil, Vijay M

    2014-01-01

    Purpose Elderly patients (65 or older) with cervical cancer often receive suboptimal radio-chemotherapy. Intensity-modulated radiotherapy (IMRT) may improve tolerance to treatment in this setting. This study was designed to compare the treatment-related toxicities and compliance with treatment in patients of cervical cancer treated definitively with RapidArc IMRT in our institute. Methods and materials The treatment records of all patients treated with RapidArc IMRT between April 2012 and April 2014 were reviewed, retrospectively. Prospectively collected data regarding treatment toxicity (CTCAE 4.0), treatment outcomes and parameters related to treatment compliance were compared amongst two age groups (< 65 and ≥ 65 years). The results of 66 patients were identified, of whom 23 were found to be ≥ 65 years age. All patients completed planned external beam radiotherapy. However, significantly fewer patients in the elderly group received concurrent chemoradiation (98% versus 65%, p < 0.001). Old age (median 75 years, IQR: 74–78 years) was the commonest cause for non-receipt of chemotherapy. Incidence of grade 3 haematological toxicities (26.7% versus 16.7%) and gastrointestinal toxicity (16.7% versus 13.3%) were not significantly different between the two groups. Other treatment-related toxicities, breaks, treatment duration and early outcomes were also not significantly different between the two age groups. Conclusions The use of IMRT did not result in excess toxicities in the elderly population and was associated with equivalent compliance to treatment. Concurrent chemoradiation can be safely combined in elderly patients with perfect organ function and performance status. PMID:25525462

  3. Early prediction of histopathological response of rectal tumors after one week of preoperative radiochemotherapy using 18 F-FDG PET-CT imaging. A prospective clinical study

    PubMed Central

    2012-01-01

    Background Preoperative radiochemotherapy (RCT) is standard in locally advanced rectal cancer (LARC). Initial data suggest that the tumor’s metabolic response, i.e. reduction of its 18 F-FDG uptake compared with the baseline, observed after two weeks of RCT, may correlate with histopathological response. This prospective study evaluated the ability of a very early metabolic response, seen after only one week of RCT, to predict the histopathological response to treatment. Methods Twenty patients with LARC who received standard RCT regimen followed by radical surgery participated in this study. Maximum standardized uptake value (SUV-MAX), measured by PET-CT imaging at baseline and on day 8 of RCT, and the changes in FDG uptake (ΔSUV-MAX), were compared with the histopathological response at surgery. Response was classified by tumor regression grade (TRG) and by achievement of pathological complete response (pCR). Results Absolute SUV-MAX values at both time points did not correlate with histopathological response. However, patients with pCR had a larger drop in SUV-MAX after one week of RCT (median: -35.31% vs −18.42%, p = 0.046). In contrast, TRG did not correlate with ΔSUV-MAX. The changes in FGD-uptake predicted accurately the achievement of pCR: only patients with a decrease of more than 32% in SUV-MAX had pCR while none of those whose tumors did not show any decrease in SUV-MAX had pCR. Conclusions A decrease in ΔSUV-MAX after only one week of RCT for LARC may be able to predict the achievement of pCR in the post-RCT surgical specimen. Validation in a larger independent cohort is planned. PMID:22853868

  4. The Right To Die. Public Talk Series.

    ERIC Educational Resources Information Center

    Pasquerella, Lynn

    This program guide on the right to die provides policy issue information where ethical concerns have a prominent place. Three positions about the right to die are presented: (1) mercy killing and assisted suicide should be legally permitted in certain cases; (2) legal status should be given to living wills and other advance directives that would…

  5. Energy Consumption of Die Casting Operations

    SciTech Connect

    Jerald Brevick; clark Mount-Campbell; Carroll Mobley

    2004-03-15

    Molten metal processing is inherently energy intensive and roughly 25% of the cost of die-cast products can be traced to some form of energy consumption [1]. The obvious major energy requirements are for melting and holding molten alloy in preparation for casting. The proper selection and maintenance of melting and holding equipment are clearly important factors in minimizing energy consumption in die-casting operations [2]. In addition to energy consumption, furnace selection also influences metal loss due to oxidation, metal quality, and maintenance requirements. Other important factors influencing energy consumption in a die-casting facility include geographic location, alloy(s) cast, starting form of alloy (solid or liquid), overall process flow, casting yield, scrap rate, cycle times, number of shifts per day, days of operation per month, type and size of die-casting form of alloy (solid or liquid), overall process flow, casting yield, scrap rate, cycle times, number of shifts per day, days of operation per month, type and size of die-casting machine, related equipment (robots, trim presses), and downstream processing (machining, plating, assembly, etc.). Each of these factors also may influence the casting quality and productivity of a die-casting enterprise. In a die-casting enterprise, decisions regarding these issues are made frequently and are based on a large number of factors. Therefore, it is not surprising that energy consumption can vary significantly from one die-casting enterprise to the next, and within a single enterprise as function of time.

  6. Prediction of Part Distortion in Die Casting

    SciTech Connect

    R. Allen Miller

    2005-03-30

    The die casting process is one of the net shape manufacturing techniques and is widely used to produce high production castings with tight tolerances for many industries. An understanding of the stress distribution and the deformation pattern of parts produced by die casting will result in less deviation from the part design specification, a better die design and eventually more productivity and cost savings. This report presents methods that can be used to simulate the die casting process in order to predict the deformation and stresses in the produced part and assesses the degree to which distortion modeling is practical for die casting at the current time. A coupled thermal-mechanical finite elements model was used to simulate the die casting process. The simulation models the effect of thermal and mechanical interaction between the casting and the die. It also includes the temperature dependant material properties of the casting. Based on a designed experiment, a sensitivity analysis was conducted on the model to investigate the effect of key factors. These factors include the casting material model, material properties and thermal interaction between casting and dies. To verify the casting distortion predictions, it was compared against the measured dimensions of produced parts. The comparison included dimensions along and across the parting plane and the flatness of one surface.

  7. Death and Dying: Issues for Educational Gerontologists.

    ERIC Educational Resources Information Center

    Wass, Hannelore, Myers, Jane E.

    1984-01-01

    Reviews research on death orientations, the dying process, and bereavement, with a major focus on the elderly. Suggests that relevant knowledge about death and dying are important for gerontological practitioners and proposes that death-related content be systematically integrated into academic curricula at the preservice and inservice levels.…

  8. Apparatus for restraining and transporting dies

    DOEpatents

    Allison, James W.; LaBarre, Timothy L.

    1994-01-01

    Apparatus for restraining and transporting dies in punch press operations is provided. A floatation platen for supporting a die on the platen's upper surface has a plurality of recessed gas exhaust ports on the platen's lower surface. A source of pressurized gas delivers gas to a platen manifold, for delivery to orifices located in the gas exhaust ports. The flow of gas is controlled by a first valve adjacent the gas source and a second valve adjacent the manifold, with the second valve being used to control the gas flow during movement of the die. In this fashion, a die may be moved on a cushion of air from one workstation to a selected second workstation. A moveable hydraulically operated restraining fixture is also provided, for clamping the die in position during the compacting phase, and for releasing the die after completion of the compacting phase by releasing the hydraulic pressure on the restraining fixture. When pressure in the hydraulic cylinders on the restraining fixture is reversed, the restraining fixture will retract so that there is no contact between the die and the restraining fixture, thereby allowing the die to be removed from a first workstation and moved to a second selected workstation.

  9. Student Nurses' Perception of Death and Dying

    ERIC Educational Resources Information Center

    Niederriter, Joan E.

    2009-01-01

    Student nurses are involved in caring for patients who are actively dying or who have been told they have a terminal illness and are faced with the process of dying. Students encounter these patients in hospitals, nursing homes, at home or in hospice care settings. According to Robinson (2004), "nurses are the healthcare providers that are most…

  10. Influence of die geometry and material selection on the behavior of protective die covers in closed-die forging

    NASA Astrophysics Data System (ADS)

    Yu, Yingyan; Rosenstock, Dirk; Wolfgarten, Martin; Hirt, Gerhard

    2016-10-01

    Due to the fact that tooling costs make up to 30% of total costs of the final forged part, the tool life is always one main research topic in closed-die forging [1]. To improve the wear resistance of forging dies, many methods like nitriding and deposition of ceramic layers have been used. However, all these methods will lose its effect after a certain time, then tool repair or exchange is needed, which requires additional time and costs. A new method, which applies an inexpensive and changeable sheet metal on the forging die to protect it from abrasive wear, was firstly proposed in [2]. According to the first investigation, the die cover is effective for decreasing thermal and mechanical loads, but there are still several challenges to overcome in this concept, like wrinkling and thinning of the die cover. Therefore, an experimental study using different geometries and die cover materials is presented within this work. The results indicate the existence of feasible application cases of this concept, since conditions are found under which a die cover made of 22MnB5 still keeps its original shape even after 7 forging cycles.

  11. The Influence of Surface Roughness and Bubbles on Sea Surface Acoustic Backscattering (Der Einfluss von Seegangsrauhigkeit und Blasen auf die Akustischen Rueckstreueigen-Schaften der Meeresoberflaeche)

    DTIC Science & Technology

    1987-11-12

    s’.gn,,ficant waveheight H1/3 (longer average times arn seicctable), * a plot of the power spectral density averaged over 0.5 hour- or 4 hours...America, vol. 61, no.2, February 1977, pp. 325-337. 5. B. Nuetzel and R. Jacobsen , Beschreibung des Nachhall-Messplatzes, Interner FWG-Bericht 1985-7

  12. Colorimetric aptasensing of ochratoxin A using Au@Fe3O4 nanoparticles as signal indicator and magnetic separator.

    PubMed

    Wang, Chengquan; Qian, Jing; Wang, Kun; Yang, Xingwang; Liu, Qian; Hao, Nan; Wang, Chengke; Dong, Xiaoya; Huang, Xingyi

    2016-03-15

    Gold nanoparticles (Au NPs) doped Fe3O4 (Au@Fe3O4) NPs have been synthesized by a facile one-step solvothermal method. The peroxidase-like activity of Au@Fe3O4 NPs was effectively enhanced due to the synergistic effect between the Fe3O4 NPs and Au NPs. On this basis, an efficient colorimetric aptasensor has been developed using the intrinsic dual functionality of the Au@Fe3O4 NPs as signal indicator and magnetic separator. Initially, the amino-modified aptamer specific for a typical mycotoxin, ochratoxin A (OTA), was surface confined on the amino-terminated glass beads surafce using glutaraldehyde as a linker. Subsequently, the amino-modified capture DNA (cDNA) was labeled with the amino-functionalized Au@Fe3O4 NPs and the aptasensor was thus fabricated through the hybridization reaction between cDNA and the aptamers. While upon OTA addition, aptamers preferred to form the OTA-aptamer complex and the Au@Fe3O4 NPs linked on the cDNA were released into the bulk solution. Through a simple magnetic separation, the collected Au@Fe3O4 NPs can produce a blue colored solution in the presence of 3,3',5,5'-tetramethylbenzidine and H2O2. When the reaction was terminated by addition of H(+) ions, the blue product could be changed into a yellow one with higher absorption intensity. This colorimetric aptasensor can detect as low as 30 pgmL(-1) OTA with high specificity. To the best of our knowledge, the present colorimetric aptasensor is the first attempt to use the peroxidase-like activity of nanomaterial for OTA detection, which may provide an acttractive path toward routine quality control of food safety.

  13. Structural and magnetic properties of core-shell Au/Fe3O4 nanoparticles

    NASA Astrophysics Data System (ADS)

    León Félix, L.; Coaquira, J. A. H.; Martínez, M. A. R.; Goya, G. F.; Mantilla, J.; Sousa, M. H.; Valladares, L. De Los Santos; Barnes, C. H. W.; Morais, P. C.

    2017-02-01

    We present a systematic study of core-shell Au/Fe3O4 nanoparticles produced by thermal decomposition under mild conditions. The morphology and crystal structure of the nanoparticles revealed the presence of Au core of d = (6.9 ± 1.0) nm surrounded by Fe3O4 shell with a thickness of ~3.5 nm, epitaxially grown onto the Au core surface. The Au/Fe3O4 core-shell structure was demonstrated by high angle annular dark field scanning transmission electron microscopy analysis. The magnetite shell grown on top of the Au nanoparticle displayed a thermal blocking state at temperatures below TB = 59 K and a relaxed state well above TB. Remarkably, an exchange bias effect was observed when cooling down the samples below room temperature under an external magnetic field. Moreover, the exchange bias field (HEX) started to appear at T~40 K and its value increased by decreasing the temperature. This effect has been assigned to the interaction of spins located in the magnetically disordered regions (in the inner and outer surface of the Fe3O4 shell) and spins located in the ordered region of the Fe3O4 shell.

  14. Structural and magnetic properties of core-shell Au/Fe3O4 nanoparticles

    PubMed Central

    León Félix, L.; Coaquira, J. A. H.; Martínez, M. A. R.; Goya, G. F.; Mantilla, J.; Sousa, M. H.; Valladares, L. de los Santos; Barnes, C. H. W.; Morais, P. C.

    2017-01-01

    We present a systematic study of core-shell Au/Fe3O4 nanoparticles produced by thermal decomposition under mild conditions. The morphology and crystal structure of the nanoparticles revealed the presence of Au core of d = (6.9 ± 1.0) nm surrounded by Fe3O4 shell with a thickness of ~3.5 nm, epitaxially grown onto the Au core surface. The Au/Fe3O4 core-shell structure was demonstrated by high angle annular dark field scanning transmission electron microscopy analysis. The magnetite shell grown on top of the Au nanoparticle displayed a thermal blocking state at temperatures below TB = 59 K and a relaxed state well above TB. Remarkably, an exchange bias effect was observed when cooling down the samples below room temperature under an external magnetic field. Moreover, the exchange bias field (HEX) started to appear at T~40 K and its value increased by decreasing the temperature. This effect has been assigned to the interaction of spins located in the magnetically disordered regions (in the inner and outer surface of the Fe3O4 shell) and spins located in the ordered region of the Fe3O4 shell. PMID:28165012

  15. Value of Diffusion-Weighted Magnetic Resonance Imaging for Prediction and Early Assessment of Response to Neoadjuvant Radiochemotherapy in Rectal Cancer: Preliminary Results

    SciTech Connect

    Lambrecht, Maarten; Vandecaveye, Vincent; De Keyzer, Frederik; Roels, Sarah; Penninckx, Freddy; Van Cutsem, Eric; Filip, Claus; Haustermans, Karin

    2012-02-01

    Purpose: To evaluate diffusion-weighted magnetic resonance imaging (DWI) for response prediction before and response assessment during and early after preoperative radiochemotherapy (RCT) for locally advanced rectal cancer (LARC). Methods and Materials: Twenty patients receiving RCT for LARC underwent MRI including DWI before RCT, after 10-15 fractions and 1 to 2 weeks before surgery. Tumor volume and apparent diffusion coefficient (ADC; b-values: 0-1000 s/mm{sup 2}) were determined at all time points. Pretreatment tumor ADC and volume, tumor ADC change ( Increment ADC), and volume change ( Increment V) between pretreatment and follow-up examinations were compared with histopathologic findings after total mesorectal excision (pathologic complete response [pCR] vs. no pCR, ypT0-2 vs. ypT3-4, T-downstaging or not). The discriminatory capability of pretreatment tumor ADC and volume, Increment ADC, and Increment V for the detection of pCR was compared with receiver operating characteristics analysis. Results: Pretreatment ADC was significantly lower in patients with pCR compared with patients without (in mm{sup 2}/s: 0.94 {+-} 0.12 Multiplication-Sign 10{sup -3} vs. 1.19 {+-} 0.22 Multiplication-Sign 10{sup -3}, p = 0.003), yielding a sensitivity of 100% and specificity of 86% for detection of pCR. The volume reduction during and after RCT was significantly higher in patients with pCR compared with patients without (in %: {Delta}V{sub during}: -62 {+-} 16 vs. -33 {+-} 16, respectively, p = 0.015; and {Delta}V{sub post}: -86 {+-} 12 vs. -60 {+-} 21, p = 0.012), yielding a sensitivity of 83% and specificity of 71% for the {Delta}V{sub during} and, respectively, 83% and 86% for the {Delta}V{sub post}. The Increment ADC during ({Delta}ADC{sub during}) and after RCT ({Delta}ADC{sub post}) showed a significantly higher value in patients with pCR compared with patients without (in %: {Delta}ADC{sub during}: 72 {+-} 14 vs. 16 {+-} 12, p = 0.0006; and {Delta}ADC{sub post}: 88

  16. Feasibility of an Adaptive Strategy in Preoperative Radiochemotherapy for Rectal Cancer With Image-Guided Tomotherapy: Boosting the Dose to the Shrinking Tumor

    SciTech Connect

    Passoni, Paolo; Fiorino, Claudio; Slim, Najla; Ronzoni, Monica; Ricci, Vincenzo; Di Palo, Saverio; De Nardi, Paola; Orsenigo, Elena; Tamburini, Andrea; De Cobelli, Francesco; Losio, Claudio; Iacovelli, Nicola A.; Broggi, Sara; Staudacher, Carlo; Calandrino, Riccardo; Di Muzio, Nadia

    2013-09-01

    Purpose: To investigate the feasibility of preoperative adaptive radiochemotherapy by delivering a concomitant boost to the residual tumor during the last 6 fractions of treatment. Methods and Materials: Twenty-five patients with T3/T4N0 or N+ rectal cancer were enrolled. Concomitant chemotherapy consisted of oxaliplatin 100 mg/m{sup 2} on days −14, 0, and +14, and 5-fluorouracil 200 mg/m{sup 2}/d from day −14 to the end of radiation therapy (day 0 is the start of radiation therapy). Radiation therapy consisted of 41.4 Gy in 18 fractions (2.3 Gy per fraction) with Tomotherapy to the tumor and regional lymph nodes (planning target volume, PTV) defined on simulation CT and MRI. After 9 fractions simulation CT and MRI were repeated for the planning of the adaptive phase: PTV{sub adapt} was generated by adding a 5-mm margin to the residual tumor. In the last 6 fractions a boost of 3.0 Gy per fraction (in total 45.6 Gy in 18 fractions) was delivered to PTV{sub adapt} while concomitantly delivering 2.3 Gy per fraction to PTV outside PTV{sub adapt}. Results: Three patients experienced grade 3 gastrointestinal toxicity; 2 of 3 showed toxicity before the adaptive phase. Full dose of radiation therapy, oxaliplatin, and 5-fluorouracil was delivered in 96%, 96%, and 88% of patients, respectively. Two patients with clinical complete response (cCR) refused surgery and were still cCR at 17 and 29 months. For the remaining 23 resected patients, 15 of 23 (65%) showed tumor regression grade 3 response, and 7 of 23 (30%) had pathologic complete response; 8 (35%) and 12 (52%) tumor regression grade 3 patients had ≤5% and 10% residual viable cells, respectively. Conclusions: An adaptive boost strategy is feasible, with an acceptable grade 3 gastrointestinal toxicity rate and a very encouraging tumor response rate. The results suggest that there should still be room for further dose escalation of the residual tumor with the aim of increasing pathologic complete response and/or c

  17. Is there a moral duty to die?

    PubMed

    Corlett, J A

    2001-01-01

    In recent years, there has been a great deal of philosophical discussion about the alleged moral right to die. If there is such a moral right, then it would seem to imply a moral duty of others to not interfere with the exercise of the right. And this might have important implications for public policy insofar as public policy ought to track what is morally right. But is there a moral duty to die? If so, under what conditions, if any, ought one to have such a duty, and why? In this paper, I distinguish between different moral grounds for the putative moral duty to die: deontological, intuitionist, and contractarian. Subsequently, I argue in support of Paul Menzel's theory of health care distribution. More precisely, I concur with his claim that there is a moral duty to die inexpensively in health care contexts. Then I provide and defend a philosophical analysis of the conditions in which such a duty could exist.

  18. House of Lords debates assisted dying (again).

    PubMed

    2003-07-01

    Lord Joffe's Patient (Assisted Dying) Bill (see Bulletin 187) had its Second Reading on 6 June. The debate was lively, informed and inevitably somewhat polarised. However, some common themes emerged and are outlined below.

  19. Casting Characteristics of Aluminum Die Casting Alloys

    SciTech Connect

    Makhlouf M. Makhlouf; Diran Apelian

    2002-02-05

    The research program investigates the casting characteristics of selected aluminum die casting alloys. Specifically, the alloys' tendencies towards die soldering and sludge formation, and the alloys' fluidity and machinability are evaluated. It was found that: When the Fe and Mn contents of the alloy are low; caution has to be taken against possible die soldering. When the alloy has a high sludge factor, particularly a high level of Fe, measures must be taken to prevent the formation of large hardspots. For this kind of alloy, the Fe content should be kept at its lowest allowable level and the Mn content should be at its highest possible level. If there are problems in die filling, measures other than changing the alloy chemistry need to be considered first. In terms of alloy chemistry, the elements that form high temperature compounds must be kept at their lowest allowable levels. The alloys should not have machining problems when appropriate machining techniques and machining parameters are used.

  20. Auf der Suche nach dem Codierungs-Gral für genetische Algorithmen

    NASA Astrophysics Data System (ADS)

    Weicker, Karsten

    Die umstrittene Frage nach dem "wichtigsten" Operator im genetischen Algorithmus - Mutation oder Crossover - hängt eng zusammen mit der Frage nach der richtigen binären Codierung. Gray- und standardbinärer Code bringen unterschiedliche Vor- und Nachteile in einen genetischen Algorithmus ein. Diese Arbeit beschäftigt sich mit der Suche nach einer Codierung, welche die Vorteile beider Codes vereinbart, und berichtet von einem Teilerfolg für mit 4 Bits encodierten Zahlen.

  1. Thick film silicon growth techniques. [die materials

    NASA Technical Reports Server (NTRS)

    Bates, H. E.; Mlavsky, A. I.; Jewett, D. N.; White, V. E.

    1973-01-01

    The research which was directed toward finding an improved die material is reported. Wetting experiments were conducted with various materials to determine their compatibility with silicon. Work has also continued toward the development of quartz as a die material as new techniques have provided more optimistic results than observed in the past. As a result of the thermal modification previously described, improvements in growth stability have contributed to an increase in ribbon quality.

  2. Machining of Silicon-Ribbon-Forming Dies

    NASA Technical Reports Server (NTRS)

    Menna, A. A.

    1985-01-01

    Carbon extension for dies used in forming silicon ribbon crystals machined precisely with help of special tool. Die extension has edges beveled toward narrow flats at top, with slot precisely oriented and centered between flats and bevels. Cutting tool assembled from standard angle cutter and circular saw or saws. Angle cutters cuts bevels while slot saw cuts slot between them. In alternative version, custom-ground edges or additional circular saws also cut flats simultaneously.

  3. Celestial Fireworks from Dying Stars

    NASA Astrophysics Data System (ADS)

    2011-04-01

    This image of the nebula NGC 3582, which was captured by the Wide Field Imager on the MPG/ESO 2.2-metre telescope at ESO's La Silla Observatory in Chile, shows giant loops of gas bearing a striking resemblance to solar prominences. These loops are thought to have been ejected by dying stars, but new stars are also being born within this stellar nursery. These energetic youngsters emit intense ultraviolet radiation that makes the gas in the nebula glow, producing the fiery display shown here. NGC 3582 is part of a large star-forming region in the Milky Way, called RCW 57. It lies close to the central plane of the Milky Way in the southern constellation of Carina (The Keel of Jason's ship, the Argo). John Herschel first saw this complex region of glowing gas and dark dust clouds in 1834, during his stay in South Africa. Some of the stars forming in regions like NGC 3582 are much heavier than the Sun. These monster stars emit energy at prodigious rates and have very short lives that end in explosions as supernovae. The material ejected from these dramatic events creates bubbles in the surrounding gas and dust. This is the probable cause of the loops visible in this picture. This image was taken through multiple filters. From the Wide Field Imager, data taken through a red filter are shown in green and red, and data taken through a filter that isolates the red glow characteristic of hydrogen are also shown in red. Additional infrared data from the Digitized Sky Survey are shown in blue. The image was processed by ESO using the observational data identified by Joe DePasquale, from the United States [1], who participated in ESO's Hidden Treasures 2010 astrophotography competition [2]. The competition was organised by ESO in October-November 2010, for everyone who enjoys making beautiful images of the night sky using astronomical data obtained using professional telescopes. Notes [1] Joe searched through ESO's archive and identified datasets that he used to compose his

  4. Living until we die: reflections on the dying person's spiritual agenda.

    PubMed

    Anderson, Herbert

    2006-03-01

    The spiritual agenda for the dying presumes a willingness to face the reality of imminent death. It also depends on support from caregivers who will encourage whatever agency is possible for the one who is dying. The spiritual practices that will enhance agency for the dying include remembering, thanking, relinquishing, waiting, and trusting. The absence of abandonment and the dependable presence of caregivers are essential to create communities and relationships in which hope can be found and sustained.

  5. Thermal Modelling In Pressure Die Casting

    NASA Astrophysics Data System (ADS)

    Rasgado, M. T. Alonso; Davey, K.; Watari, H.

    2004-06-01

    The pressure die casting process is cyclic and the temperature levels in the die are principally dictated by the total energy received from the casting. It is thus extremely important that any solidification model for the casting is able to predict energy extraction rates to a high degree of accuracy. In this paper an efficient three dimensional hybrid thermal model for the pressure die casting process is described. The finite element method (FEM) is used for modelling heat transfer in the casting, coupled to a boundary element (BE) model for the die. The FEM can efficiently account for the non-linearity introduced by the release of latent heat on solidification, whereas the BEM is ideally suited for modelling linear heat conduction in the die, as surface temperatures are of principal importance. The FE formulation for the casting is based on a control volume capacitance method, which is shown to provide high accuracy and stability. This method is similar to the apparent and effective heat capacitance methods, which are popular approaches used where conduction predominates over other heat transfer mechanisms. These methods involve the specification of element or nodal capacitances to accommodate for the release of latent heat. Unfortunately they suffer from a major drawback in that energy is not correctly transported through elements and so providing a source of inaccuracy. The control volume capacitance method allows for the transport of mass arising from volumetric shrinkage and ensures that energy is correctly transported. The BE model caters for surface phenomena such as boiling in the cooling channels, which is important, as this effectively controls the manner in which energy is extracted. The die temperature is decomposed into two components, one a steady-state part and the other a time-dependent perturbation. This approach enables the transient die temperatures to be calculated in an efficient way, since only die surfaces close to the die cavity are

  6. Effekt einer ad libitum verzehrten fettreduzierten Kost, reich an Obst, Gemüse und Milchprodukten auf den Blutdruck bei Borderline-Hypertonikern

    NASA Astrophysics Data System (ADS)

    Möseneder, Jutta M.

    2002-01-01

    In der randomisierten, multizentrischen DASH-Studie (Dietary Approaches to Stop Hy-pertension), die unter kontrollierten Bedingungen stattfand, führte eine fettreduzierte Mischkost, reich an Obst, Gemüse und Milchprodukten, bei Borderline-Hypertonikern zu einer signifikanten Blutdrucksenkung. Während der Studienphase wurden Körpermasse, Natrium-Aufnahme sowie Alkoholzufuhr aufgrund der bekannten Einflussnahme auf den Blutdruck konstant gehalten. In der eigenen Pilot-Studie sollte untersucht werden, ob das Ergebnis der DASH-Studie (i) mit deutschen Hypertonikern und (ii) unter habituellen Ernährungs- und Lebensbedingungen mit regelmäßig durchgeführter Ernährungsberatung und ad libitum Verzehr anstelle des streng kontrollierten Studienansatzes bestätigt werden kann. Eine Konstanz der Körpermasse, der Natrium-Urinausscheidung (unter diesem Studienansatz valider als die Aufnahme) und des Alkoholkonsums wurde vorausgesetzt. Die Studienpopulation setzte sich aus 53 übergewichtigen Probanden mit einer nicht medikamentös therapierten Borderline-Hypertonie und ohne Stoffwechselerkrankungen zusammen. Die Studienteilnehmer wurden randomisiert entweder der Idealgruppe mit einer fettarmen Kost reich an Milchprodukten, Obst und Gemüse (ähnlich der DASH-Idealgruppe) oder der Kontrollgruppe mit habitueller Ernährungsweise zugeteilt. Über einen Zeitraum von fünf Wochen wurde den Probanden etwa 50% ihres täglichen Lebensmittelbedarfes entsprechend ihrer Gruppenzugehörigkeit kostenfrei zur Verfügung gestellt. Gelegenheitsblutdruckmessungen und 24h-Blutdruckmessungen, Ernährungs- und Aktivitätsprotokolle, Blut- und Urinproben sowie anthropometrische Messungen wurden vor, während und fünf Wochen nach der Interventionsphase durchgeführt. Die Ergebnisse zeigen, dass in der Idealgruppe keine signifikante Blutdrucksenkung beobachtet werden konnte. Dies lässt sich durch die Tatsache erklären, dass die Lebens-mittel- und Nährstoffaufnahme der deutschen

  7. Compassionate community networks: supporting home dying.

    PubMed

    Abel, Julian; Bowra, Jon; Walter, Tony; Howarth, Glennys

    2011-09-01

    How may communities be mobilised to help someone dying at home? This conceptual article outlines the thinking behind an innovative compassionate community project being developed at Weston-super-Mare, UK. In this project, a health professional mentors the dying person and their carer to identify and match: (a) the tasks that need to be done and (b) the members of their social network who might help with these tasks. Network members may subsequently join a local volunteer force to assist others who are network poor. Performing practical tasks may be more acceptable to some family, friends and neighbours than having to engage in a conversation about dying, and provides a familiarity with dying that is often lacking in modern societies, so in this model, behavioural change precedes attitudinal change. The scheme rejects a service delivery model of care in favour of a community development model, but differs from community development schemes in which the mentor is a volunteer rather than a health professional, and also from those approaches that strive to build community capacity before any one individual dying person is helped. The pros and cons of each approach are discussed. There is a need for evaluation of this and similar schemes, and for basic research into naturally occurring resource mobilisation at the end of life.

  8. Killing, letting die and moral perception.

    PubMed

    Gillett, Grant

    1994-10-01

    There are a number of arguments that purport to show, in general terms, that there is no difference between killing and letting die. These are used to justify active euthanasia on the basis of the reasons given for allowing patients to die. I argue that the general and abstract arguments fail to take account of the complex and particular situations which are found in the care of those with terminal illness. When in such situations, there are perceptions and intuitions available that do not easily find propositional form but lead most of those whose practice is in the care of the dying to resist active euthanasia. I make a plea for their intuitions to be heeded above the sterile voice of abstract premises and arguments by examining the completeness of the outline form of the pro-euthanasia argument. In doing so, I make use of Nussbaum's discussion of moral perception and general claims to be found in the literature of moral particularism.

  9. CAE Based Die Face Engineering Development to Contribute to the Revitalization of the Tool & Die Industry

    NASA Astrophysics Data System (ADS)

    Tang, Arthur; Lee, Wing C.; St. Pierre, Shawn; He, Jeanne; Liu, Kesu; Chen, Chin C.

    2005-08-01

    Over the past two decades, the Computer Aided Engineering (CAE) tools have emerged as one of the most important engineering tools in various industries, due to its flexibility and accuracy in prediction. Nowadays, CAE tools are widely used in the sheet metal forming industry to predict the forming feasibility of a wide variety of complex components, ranging from aerospace and automotive components to household products. As the demand of CAE based formability accelerates, the need for a robust and streamlined die face engineering tool becomes more crucial, especially in the early stage when the tooling layout is not available, but a product design decision must be made. Ability to generate blank, binder and addendum surfaces with an appropriate layout of Drawbead, Punch Opening Line, Trim Line are the primary features and functions of a CAE based die face engineering tool. Once the die face layout is ready, a formability study should be followed to verify the die face layout is adequate to produce a formable part. If successful, the established die face surface should be exported back to the CAD/CAM environment to speed up the tooling and manufacturing design process with confidence that this particular part is formable with this given die face. With a CAE tool as described above, the tool & die industry will be greatly impacted as the processes will enable the bypass of hardware try-out and shorten the overall vehicle production timing. The trend has shown that OEMs and first tiers will source to low cost producers in the world which will have a negative impact to the traditional tool & die makers in the developed countries. CAE based tool as described should be adopted, along with many other solutions, in order to maintain efficiency of producing high quality product and meeting time-to-market requirements. This paper will describe how a CAE based die face engineering (DFE) tool could be further developed to enable the traditional tool & die makers to meet the

  10. Multifunctional Au-Fe3O4@MOF core-shell nanocomposite catalysts with controllable reactivity and magnetic recyclability

    NASA Astrophysics Data System (ADS)

    Ke, Fei; Wang, Luhuan; Zhu, Junfa

    2014-12-01

    The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional catalysts used in the reduction of 4-nitrophenol, this porous MOF-based magnetic catalyst is green, cheap and promising for industrial applications.The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional

  11. Effect of Die Strength and Work Piece Strength on the Wear of Hot Forging Dies

    NASA Astrophysics Data System (ADS)

    Levy, B. S.; Van Tyne, C. J.

    2015-01-01

    The effect of the strength ratio extracted from an Archard model for wear is used to describe the wear rates expected in hot forging dies. In the current study, the strength ratio is the strength of the hot forging die to the strength of the work piece. Three hot forging die steels are evaluated. The three die steels are FX, 2714, and WF. To determine the strength of the forging die, a continuous function has been developed that describes the yield strength of three die steels for temperatures from 600 to 700 °C and for times up to 20 h (i.e., tempering times of up to 20 h). The work piece material is assumed to be AISI 1045. Based on the analysis, the wear resistance of WF should be superior and FX should be slightly better than 2714. Decreasing the forging temperature increases the strength ratio, because the strength of the die surface increases faster than the flow strength of AISI 1045. The increase in the strength ratio indicates a decrease in the expected wear rate.

  12. Wissenschaft, die unsere Kultur verändert. Tiefenschichten des Streits um die Evolutionstheorie

    NASA Astrophysics Data System (ADS)

    Patzelt, Werner J.

    Die Evolutionstheorie ist eine der erfolgreichsten wissenschaftlichen Theorien. Sie erlaubt es, unsere Herkunft zu verstehen und riskante Merkmale gerade der menschlichen Spezies zu begreifen. Zugleich ist die Evolutionstheorie eine der umstrittensten Theorien. Das liegt nicht an ihrer empirischen Tragfähigkeit, sondern an ihrem Gegenstand. Sie handelt nämlich nicht nur - wie Hunderte andere wissenschaftliche Theorien - von der "Welt da draußen“, sondern vor allem auch von uns selbst und von unserem Platz in dieser Welt. Den einen gilt sie obendrein als Überwinderin religiösen Aberglaubens, den anderen als neuer Zugang zu Gott und seinem Wirken in der Welt. Ferner sehen die einen in der Evolution eine unbezweifelbare Tatsache gleich der Schwerkraft oder dem Holocaust, die anderen aber eine - noch oder dauerhaft - unbewiesene Hypothese oder gar eine falsche Schöpfungslehre. Und während die meisten Streitfragen solcher Art nach wechselseitig akzeptierten Regeln ‚normaler Wissenschaft‘ geklärt werden, wird bei der Frage nach dem Woher unserer Spezies und Kultur die intellektuelle Zuständigkeit von Wissenschaft mitunter überhaupt bezweifelt. Anscheinend geht es schon um recht tiefe Schichten unserer Kultur und nicht nur der wissenschaftlichen, wenn - wie seit 150 Jahren - um die Evolutionstheorie gestritten wird. Wie sehen diese Schichten aus?

  13. Investigation of Die Stress Profiles during Powder Compaction using Instrumented Die

    SciTech Connect

    Hong, Sung-tae; Hovanski, Yuri; Lavender, Curt A.; Weil, K. Scott

    2008-06-01

    The radial stress profile in a cylindrical die during compaction of titanium (Ti) powder was investigated by experiments. The concept of an instrumented die was extended to design an enhanced instrumented die. Custom-made strain gage pins were used to measure the radial stress during powder compaction. The test fixture was designed to simulate double-action pressing. The measured die stress profile for Ti powder was compared with that for a commercially available iron (Fe) powder. The stress history shows that an appreciable residual stress remains in the die in the radial direction after the axial compaction stress is removed from the powder. Furthermore, the radial stress profile in the die, while under maximum axial compaction stress, is more uniform across the height of the Fe compact than that of the Ti compact. In addition, the residual stress profile in the die in the radial direction reduces symmetrically in both directions beyond the height of the compact for both powders. Finally, the Ti powder shows a significantly higher frictional coefficient at the maximum axial compaction stress, and consequently a higher maximum axial ejection stress than the Fe powder.

  14. A profile of silicosis cases who died.

    PubMed

    Phoon, W H

    1982-01-01

    Silicosis cases which had been notified by doctors and confirmed after investigations were followed up by the Industrial Health Division. Up to August 1981, a total of 313 persons were confirmed as having the disease. Of these, 59 had died. The majority of these 59 persons had had their silica exposure in the granite quarries. 13 had been exposed to "rubber powder" which contained a high percentage of free silica. 52 of those who died were male, and their average age at death was 60.87 years. This did not appear to be significantly shorter than their life expectancy of 65.1 years. But the average age of death for the 7 women was 58.86 years, which was much shorter than their life expectancy of 70 years. Many of the men died from causes unrelated to silicosis. But 6 of the 7 women had progressive massive fibrosis (PMF) and they apparently died of the disease or complications arising from it.

  15. Expectation and Variation with a Virtual Die

    ERIC Educational Resources Information Center

    Watson, Jane; English, Lyn

    2015-01-01

    By the time students reach the middle years they have experienced many chance activities based on dice. Common among these are rolling one die to explore the relationship of frequency and theoretical probability, and rolling two dice and summing the outcomes to consider their probabilities. Although dice may be considered overused by some, the…

  16. Stamping Die Making. 439-318/320.

    ERIC Educational Resources Information Center

    Yunke, P.; And Others

    Each unit in this curriculum guide on stamping die making contains an introduction, objectives, materials required, lessons, space for notes, figures, and diagrams. There are 29 units in this guide, dealing with the following topics: EZ-MILL programming; EZ-MILL BATT; print of punch and EZ-MILL part programming; download to Computer Numerical…

  17. Care of the Dying: A Swedish Perspective

    ERIC Educational Resources Information Center

    Feigenberg, Loma; Fulton, Robert

    1977-01-01

    This article illustrates various aspects of terminal care, and shows that rules and norms for such care do not exist today. The authors advocate the formulation of an aim for humane treatment of dying patients, and its application in a manner appropriate to Swedish medical concepts and Swedish conditions. (Author)

  18. Asymmetric Die Grows Purer Silicon Ribbon

    NASA Technical Reports Server (NTRS)

    Kalejs, J. P.; Chalmers, B.; Surek, T.

    1983-01-01

    Concentration of carbide impurities in silicon ribbon is reduced by growing crystalline ribbon with die one wall higher than other. Height difference controls shape of meniscus at liquid/crystal interface and concentrates silicon carbide impurity near one of broad faces. Opposite face is left with above-average purity. Significantly improves efficiency of solar cells made from ribbon.

  19. Ceramic for Silicon-Shaping Dies

    NASA Technical Reports Server (NTRS)

    Sekercioglu, I.; Wills, R. R.

    1982-01-01

    Silicon beryllium oxynitride (SiBON) is a promising candidate material for manufacture of shaping dies used in fabricating ribbons or sheets of silicon. It is extremely stable, resists thermal shock, and has excellent resistance to molten silicon. SiBON is a solid solution of beryllium silicate in beta-silicon nitride.

  20. The Onion and "When Legends Die."

    ERIC Educational Resources Information Center

    Bell, Loren C.

    1984-01-01

    Describes the eight layers in Thomas Black Bull's ("When the Legends Die") journey to spiritual rebirth and stresses that students can easily identify these layers and can thereby achieve a clearer understanding of the relationship between structure and meaning in fiction. (CRH)

  1. Counseling Older Persons: Careers, Retirement, Dying.

    ERIC Educational Resources Information Center

    Sinick, Daniel

    The focus of this monograph is on three areas of counseling with older clients: career counseling, retirement counseling, and counseling regarding death and dying. The portion on career counseling includes reasons older persons change careers, obstacles they are likely to face when seeking employment, myths surrounding the employability of older…

  2. Mold Die Making. 439-322/324.

    ERIC Educational Resources Information Center

    Yunke, P.; And Others

    Each unit in this curriculum guide on mold die making contains an introduction, objectives, materials required, lessons, space for notes, figures, and diagrams. There are 10 units in this guide: (1) introduction to Electrical Discharge Machining (EDM); (2) EDM principles; (3) the single pulse; (4) EDM safety; (5) electrode material; (6) electrode…

  3. [Companionship for women dying of AIDS].

    PubMed

    Gerlach, E

    1999-01-01

    This report reflects the experience of accompanying HIV-infected women during the process of dying using their curriculi vitae as examples of different modes of dealing with fatal illness. The text contains paintings of past and contemporary art concerning death and eros and poetry as a form of therapy.

  4. The Academic Study of Death and Dying.

    ERIC Educational Resources Information Center

    Amend, Edward W.

    The current study of death and dying is an example of constant change and development in academic disciplines. While the discussion of death in time of crisis is hard, if not impossible, youthful undergraduates find this topic to be of considerable interest. For them, a course can be organized effectively as a small and intimate seminar, which…

  5. AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus

    PubMed Central

    Lee, Nara; Pimienta, Genaro; Steitz, Joan A.

    2012-01-01

    Epstein-Barr virus (EBV)–infected cells express two noncoding RNAs called EBV-encoded RNA (EBER) 1 and EBER2. Despite their high abundance in the nucleus (about 106 copies), the molecular function of these noncoding RNAs has remained elusive. Here, we report that the insertion into EBER1 of an RNA aptamer that binds the bacteriophage MS2 coat protein allows the isolation of EBER1 and associated protein partners. By combining MS2-mediated selection with stable isotope labeling of amino acids in cell culture (SILAC) and analysis by mass spectrometry, we identified AUF1 (AU-rich element binding factor 1)/hnRNP D (heterogeneous nuclear ribonucleoprotein D) as an interacting protein of EBER1. AUF1 exists as four isoforms generated by alternative splicing and is best known for its role in destabilizing mRNAs upon binding to AU-rich elements (AREs) in their 3′ untranslated region (UTR). Using UV crosslinking, we demonstrate that predominantly the p40 isoform of AUF1 interacts with EBER1 in vivo. Electrophoretic mobility shift assays show that EBER1 can compete for the binding of the AUF1 p40 isoform to ARE-containing RNA. Given the high abundance of EBER1 in EBV-positive cells, EBER1 may disturb the normal homeostasis between AUF1 and ARE-containing mRNAs or compete with other AUF1-interacting targets in cells latently infected by EBV. PMID:23012480

  6. AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus.

    PubMed

    Lee, Nara; Pimienta, Genaro; Steitz, Joan A

    2012-11-01

    Epstein-Barr virus (EBV)-infected cells express two noncoding RNAs called EBV-encoded RNA (EBER) 1 and EBER2. Despite their high abundance in the nucleus (about 10(6) copies), the molecular function of these noncoding RNAs has remained elusive. Here, we report that the insertion into EBER1 of an RNA aptamer that binds the bacteriophage MS2 coat protein allows the isolation of EBER1 and associated protein partners. By combining MS2-mediated selection with stable isotope labeling of amino acids in cell culture (SILAC) and analysis by mass spectrometry, we identified AUF1 (AU-rich element binding factor 1)/hnRNP D (heterogeneous nuclear ribonucleoprotein D) as an interacting protein of EBER1. AUF1 exists as four isoforms generated by alternative splicing and is best known for its role in destabilizing mRNAs upon binding to AU-rich elements (AREs) in their 3' untranslated region (UTR). Using UV crosslinking, we demonstrate that predominantly the p40 isoform of AUF1 interacts with EBER1 in vivo. Electrophoretic mobility shift assays show that EBER1 can compete for the binding of the AUF1 p40 isoform to ARE-containing RNA. Given the high abundance of EBER1 in EBV-positive cells, EBER1 may disturb the normal homeostasis between AUF1 and ARE-containing mRNAs or compete with other AUF1-interacting targets in cells latently infected by EBV.

  7. Multifunctional Au-Fe3O4@MOF core-shell nanocomposite catalysts with controllable reactivity and magnetic recyclability.

    PubMed

    Ke, Fei; Wang, Luhuan; Zhu, Junfa

    2015-01-21

    The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional catalysts used in the reduction of 4-nitrophenol, this porous MOF-based magnetic catalyst is green, cheap and promising for industrial applications.

  8. Effects of coating molecules on the magnetic heating properties of Au-Fe3O4 heterodimer nanoparticles

    NASA Astrophysics Data System (ADS)

    Yamamoto, Y.; Ogasawara, J.; Himukai, H.; Itoh, T.

    2016-10-01

    In this paper, we report the heating properties of gold-magnetite (Au-Fe3O4) heterodimer nanoparticles (NPs) subjected to an alternating magnetic field. The Au-Fe3O4 NPs coated with oleic acid and oleylamine (OA) were synthesized through a method that combines seed mediation and high-temperature decomposition. The coating was replaced with dimercaptosuccinic acid (DMSA) by the ligand-exchange method. The specific absorption rates (SARs) for the OA- and DMSA-coated Au-Fe3O4 NPs coated with OA and DMSA at room temperature were determined through the calorimetric and magnetometric methods. SAR depended on the square of the magnetic field H up to an H value of 4 kA/m. The absolute value of the SAR for DMSA-coated NPs is about fivefold higher than that of the OA-coated NPs. The AC magnetic hysteresis measurements showed the recovery of the magnetic volume and the decrease in the magnetic anisotropy of the DMSA-coated NPs relative to those of the OA-coated NPs. These results suggest that the protective agent influences the magnetic properties of magnetite NPs via gold NPs.

  9. Strong dependence of surface plasmon resonance and surface enhanced Raman scattering on the composition of Au-Fe nanoalloys.

    PubMed

    Amendola, Vincenzo; Scaramuzza, Stefano; Agnoli, Stefano; Polizzi, Stefano; Meneghetti, Moreno

    2014-01-01

    Nanoalloys of noble metals with transition metals are crucial components for the integration of plasmonics with magnetic and catalytic properties, as well as for the production of low-cost photonic devices. However, due to synthetic challenges in the realization of nanoscale solid solutions of noble metals and transition metals, very little is known about the composition dependence of plasmonic response in nanoalloys. Here we demonstrate for the first time that the elemental composition of Au-Fe nanoalloys obtained by laser ablation in liquid solution can be tuned by varying the liquid environment. Due to surface passivation and reaction with thiolated ligands, the nanoalloys obtained by our synthetic protocol are structurally and colloidally stable. Hence, we studied the dependence of the surface plasmon resonance (SPR) on the iron fraction and, for the first time, we observed surface enhanced Raman scattering (SERS) in Au-Fe nanoalloys. SPR and SERS performances are strongly affected by the iron content and are investigated using analytical and numerical models. By demonstrating the strong modification of plasmonic properties on the composition, our results provide important insights into the exploitation of Au-Fe nanoalloys in photonics, nanomedicine, magneto-plasmonic and plasmon-enhanced catalysis. Moreover, our findings show that several other plasmonic materials exist beyond gold and silver nanostructures.

  10. Electronic structure and vibrational entropies of fcc Au-Fe alloys

    SciTech Connect

    Munoz, Jorge A.; Lucas, Matthew; Mauger, L; Halevy, I; Horwath, J; Semiatin, S L; Xiao, Yuming; Stone, Matthew B; Abernathy, Douglas L; Fultz, B.

    2013-01-01

    Phonon density of states (DOS) curves were measured on alloys of face-centered-cubic (fcc) Au-Fe using nuclear resonant inelastic x-ray scattering (NRIXS) and inelastic neutron scattering (INS). The NRIXS and INS results were combined to obtain the total phonon DOS and the partial phonon DOS curves of Au and Fe atoms. The 57Fe partial phonon DOS of the dilute alloy Au0.97 57Fe0.03 shows a localized mode centered 4.3% above the cutoff energy of the phonons in pure Au. The Mannheim model for impurity modes accurately reproduced this partial phonon DOS using the fcc Au phonon DOS with a ratio of host-host to impurity-host force constants of 1.55. First-principles calculations validated the assumption of first-nearest-neighbor forces in the Mannheim model and gave a similar ratio of force constants. The high energy local mode broadens with increasing Fe composition, but this has a small effect on the composition dependence of the vibrational entropy. The main effect on the vibrational entropy of alloying comes from a stiffening of the Au partial phonon DOS with Fe concentration. This stiffening is attributed to two main effects: 1) an increase in electron density in the free-electron-like states, and 2) stronger sd-hybridization. These two effects are comparable in magnitude.

  11. Annealing-induced recovery of indents in thin Au(Fe) bilayer films

    PubMed Central

    Kosinova, Anna; Schwaiger, Ruth; Klinger, Leonid

    2016-01-01

    We employed depth-sensing nanoindentation to produce ordered arrays of indents on the surface of 50 nm-thick Au(Fe) films deposited on sapphire substrates. The maximum depth of the indents was approximately one-half of the film thickness. The indented films were annealed at a temperature of 700 °C in a forming gas atmosphere. While the onset of solid-state dewetting was observed in the unperturbed regions of the film, no holes to the substrate were observed in the indented regions. Instead, the film annealing resulted in the formation of hillocks at the indent locations, followed by their dissipation and the formation of shallow depressions nearby after subsequent annealing treatments. This annealing-induced evolution of nanoindents was interpreted in terms of annihilation of dislocation loops generated during indentation, accompanied by the formation of nanopores at the grain boundaries and their subsequent dissolution. The application of the processes uncovered in this work show great potential for the patterning of thin films. PMID:28144556

  12. Kopplung eines auf der Momentenmethode basierenden Computerprogramms mit einem FEM-Algorithmus zur Berechnung von elektromagnetischen Streuproblemen im medizinischen Bereich

    NASA Astrophysics Data System (ADS)

    Schick, M.; Landstorfer, F. M.

    2004-05-01

    Am Beispiel der Verkopplung von medizinischen Geräten über den menschlichen Körper werden elektromagnetische Störphänomene im Klinikbereich betrachtet. Für die Berechnung dieser komplexen Szenarien wird zum einen die Momentenmethode (MoM) verwendet, die sich in besonderem Maße für die Berücksichtigung metallischer Strukturen und offener Streuprobleme eignet, und zum anderen die Methode der Finiten Elemente (FEM), mit der die Eigenschaften des menschlichen Körpers besser berücksichtigt werden können. Mit Hilfe des Äquivalenzprinzips lässt sich das Gesamtproblem in zwei Teile zerlegen, in ein inneres und in ein äußeres. Der Außenraum wird dabei mit der MoM behandelt und das Innere, d.h. der Körper mit der FEM. Die Kopplung der beiden Methoden erfolgt an der Körperoberfläche über äquivalente Oberflächenströme. Durch Lösen des resultierenden linearen Gleichungssystems für das gesamte Problem lassen sich dann die Oberflächenströme und die über die Kontinuitätsgleichung miteinander verknüpften elektromagnetischen Felder bestimmen.

  13. Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study

    PubMed Central

    Gagel, Bernd; Piroth, Marc; Pinkawa, Michael; Reinartz, Patrick; Krohn, Thomas; Kaiser, Hans J; Stanzel, Sven; Breuer, Christian; Asadpour, Branka; Schmachtenberg, Axel; Eble, Michael J

    2007-01-01

    Background The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC) and to evaluate the efficacy of this regime in a phase II study. Methods 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m2) and vinorelbine (30 mg/m2) at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [18F] fluorodeoxyglucose positron emission tomography (FDG PET) based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m2. The dose of gemcitabine was increased in steps of 100 mg/m2 until the MTD was realized. Results MTD was defined for the patient group receiving gemcitabine 500 mg/m2 due to grade 2 (next to grade 3) esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg), representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT) grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months). The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7]) months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6]) months. Conclusion After induction

  14. Spiritual aspects of death and dying.

    PubMed Central

    Mermann, A. C.

    1992-01-01

    Dying is an event beyond our comprehension, an experience that can only be imagined. Patients with cancer have a gift denied many others: some time to prepare for the approaching end of life. This time can be used to bring old conflicts to a close, to say goodbye and seek forgiveness from others, to express love and gratitude for the gifts of a life. Physicians can help patients by being aware of the spiritual dimensions to life that many patients have. In major religious traditions, death is accepted as the natural end of the gift of life and as a point of transition to another, yet unknown, existence. For many patients, it is not death that is feared, but abandonment. The physician's awareness of the spiritual needs of patients can make care of the dying more rewarding and fulfilling for all concerned. PMID:1519377

  15. Architecture for on-die interconnect

    SciTech Connect

    Khare, Surhud; More, Ankit; Somasekhar, Dinesh; Dunning, David S.

    2016-03-15

    In an embodiment, an apparatus includes: a plurality of islands configured on a semiconductor die, each of the plurality of islands having a plurality of cores; and a plurality of network switches configured on the semiconductor die and each associated with one of the plurality of islands, where each network switch includes a plurality of output ports, a first set of the output ports are each to couple to the associated network switch of an island via a point-to-point interconnect and a second set of the output ports are each to couple to the associated network switches of a plurality of islands via a point-to-multipoint interconnect. Other embodiments are described and claimed.

  16. Clayton's compromises and the assisted dying debate.

    PubMed

    Parker, Malcolm

    2015-03-01

    Richard Huxtable has recently argued that while assisted dying has been both repeatedly condemned and commended, a compromise resolution is possible. Following critique of other purported solutions, he argues for a new legal offence of "compassionate killing" as a plausible compromise between supporters and opponents of legalised assisted dying, because it offers something of significance to both sides. However, it turns out that "compassionate killing" would leave both sides with insufficient net benefit for the proposal to qualify as a compromise between them. By analogy with another apparently intractable bioethical debate, concerning destructive embryo research, this column rejects Huxtable's solution as another "Clayton's compromise". True compromise is not possible in bioethical debates involving divisions over deeply held values and world views. Resolving such debates inevitably involves the substitution of one dominant world view with another.

  17. Fewer Patients Die During Hospital Inspection Weeks: Study

    MedlinePlus

    ... 164254.html Fewer Patients Die During Hospital Inspection Weeks: Study Slight differences in death rates were possibly ... likely to die if they are treated during weeks that inspectors are checking on the staff, a ...

  18. Historical review of die drool phenomenon during plastics extrusion

    NASA Astrophysics Data System (ADS)

    Musil, Jan; Zatloukal, Martin

    2013-04-01

    Die drool phenomenon is defined as unwanted spontaneous accumulation of extruded polymer melt on open faces of extrusion die during extrusion process. Such accumulated material builds up on the die exit and frequently or continually sticks onto the extruded product and thus damages it. Since die drool appears, extrusion process must be shut down and die exit must be manually cleaned which is time and money consuming. Although die drool is complex phenomenon and its formation mechanism is not fully understood yet, variety of proposed explanations of its formation mechanism and also many ways to its elimination can be found in open literature. Our review presents in historical order breakthrough works in the field of die drool research, shows many ways to suppress it, introduces methods for its quantitative evaluation and composition analysis and summarizes theories of die drool formation mechanism which can be helpful for extrusion experts.

  19. A Contextualist Thanatology: A Pragmatic Approach to Death and Dying

    ERIC Educational Resources Information Center

    Reck, Andrew J.

    1977-01-01

    Denying the value of death but accepting its reality, the author points to dying, not death, as the problematic phenomenon with which a pragmatist thanatology must deal. It is suggested that dying contains opportunities for growth--for the dying as well as for their surviving friends and relatives. (Author)

  20. Darwin als Sehhilfe für die Psychologie - Evolutionspsychologie

    NASA Astrophysics Data System (ADS)

    Schwab, Frank

    Im Folgenden geht es um Einäugige, stereoskopisches Sehen, weite und enge Horizonte, Monokel und Sonnenbrillen. Der Beitrag versucht die Metapher des Sehens und der Sehhilfen anzuwenden, um so zu verdeutlichen, welchen Gewinn die herkömmliche Psychologie durch die Verwendung einer Darwin'schen Brille erlangen kann.

  1. A Contingency Framework for Listening to the Dying

    ERIC Educational Resources Information Center

    Vora, Erika; Vora, Ariana

    2008-01-01

    Listening to the dying poses special challenges. This paper proposes a contingency framework for describing and assessing various circumstances when listening to the dying. It identifies current approaches to listening, applies the contingency framework toward effectively listening to the dying, and proposes a new type of listening called…

  2. Die and telescoping punch form convolutions in thin diaphragm

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Die and punch set forms convolutions in thin dished metal diaphragm without stretching the metal too thin at sharp curvatures. The die corresponds to the metal shape to be formed, and the punch consists of elements that progressively slide against one another under the restraint of a compressed-air cushion to mate with the die.

  3. 5 Ways to Cope When a Loved One Dies

    MedlinePlus

    ... Week of Healthy Breakfasts Shyness 5 Ways to Cope When a Loved One Dies KidsHealth > For Teens > 5 Ways to Cope When a Loved One Dies Print A A ... Here are 5 ideas that might help you cope when someone you love has died: Join in ...

  4. 25 CFR 304.2 - Marking and ownership of dies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Marking and ownership of dies. 304.2 Section 304.2 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.2 Marking and ownership of dies. All dies used to mark silver will be provided by...

  5. 25 CFR 304.2 - Marking and ownership of dies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Marking and ownership of dies. 304.2 Section 304.2 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.2 Marking and ownership of dies. All dies used to mark silver will be provided by...

  6. 25 CFR 304.5 - Dies to identify tribe.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Dies to identify tribe. 304.5 Section 304.5 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.5 Dies to identify tribe. Dies are marked with name of tribe. A Navajo stamp will...

  7. 25 CFR 304.2 - Marking and ownership of dies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Marking and ownership of dies. 304.2 Section 304.2 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.2 Marking and ownership of dies. All dies used to mark silver will be provided by...

  8. 25 CFR 304.2 - Marking and ownership of dies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Marking and ownership of dies. 304.2 Section 304.2 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.2 Marking and ownership of dies. All dies used to mark silver will be provided by...

  9. 25 CFR 304.5 - Dies to identify tribe.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Dies to identify tribe. 304.5 Section 304.5 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.5 Dies to identify tribe. Dies are marked with name of tribe. A Navajo stamp will...

  10. 25 CFR 304.5 - Dies to identify tribe.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Dies to identify tribe. 304.5 Section 304.5 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.5 Dies to identify tribe. Dies are marked with name of tribe. A Navajo stamp will...

  11. 25 CFR 304.5 - Dies to identify tribe.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Dies to identify tribe. 304.5 Section 304.5 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.5 Dies to identify tribe. Dies are marked with name of tribe. A Navajo stamp will...

  12. 25 CFR 301.3 - Specifications of dies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Specifications of dies. 301.3 Section 301.3 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.3 Specifications of dies. Dies used are to be entirely hand-made, with no...

  13. 25 CFR 304.5 - Dies to identify tribe.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Dies to identify tribe. 304.5 Section 304.5 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF GOVERNMENT MARK § 304.5 Dies to identify tribe. Dies are marked with name of tribe. A Navajo stamp will...

  14. 25 CFR 301.4 - Application of dies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Application of dies. 301.4 Section 301.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.4 Application of dies. Dies are to be applied to the object with the aid...

  15. 25 CFR 301.4 - Application of dies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Application of dies. 301.4 Section 301.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.4 Application of dies. Dies are to be applied to the object with the aid...

  16. 25 CFR 301.4 - Application of dies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Application of dies. 301.4 Section 301.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.4 Application of dies. Dies are to be applied to the object with the aid...

  17. 25 CFR 301.3 - Specifications of dies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Specifications of dies. 301.3 Section 301.3 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.3 Specifications of dies. Dies used are to be entirely hand-made, with no...

  18. 25 CFR 301.4 - Application of dies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Application of dies. 301.4 Section 301.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.4 Application of dies. Dies are to be applied to the object with the aid...

  19. 25 CFR 301.3 - Specifications of dies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Specifications of dies. 301.3 Section 301.3 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.3 Specifications of dies. Dies used are to be entirely hand-made, with no...

  20. 25 CFR 301.4 - Application of dies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Application of dies. 301.4 Section 301.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.4 Application of dies. Dies are to be applied to the object with the aid...

  1. 25 CFR 301.3 - Specifications of dies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Specifications of dies. 301.3 Section 301.3 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.3 Specifications of dies. Dies used are to be entirely hand-made, with no...

  2. 25 CFR 301.3 - Specifications of dies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Specifications of dies. 301.3 Section 301.3 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER AND TURQUOISE PRODUCTS; STANDARDS § 301.3 Specifications of dies. Dies used are to be entirely hand-made, with no...

  3. Differentiating suicide decedents who died using firearms from those who died using other methods.

    PubMed

    Anestis, Michael D; Khazem, Lauren R; Anestis, Joye C

    2017-02-22

    Studies have documented a link between gun ownership and suicide, but little is known about characteristics of those most likely to use a gun in a suicide attempt rather than alternative methods. We examined which factors differentiate suicide decedents who died using a gun from those who died by other methods. We further examined whether such findings are consistent within the subcomponent of our larger sample comprised entirely of gun owning suicide decedents. Data reflect 267 suicide decedents, with data provided by individuals who identified as having lost someone to suicide (loss survivors). Within the full sample, a higher proportion of gun-owning and male suicide decedents died by firearm. Further, individuals who had previously discussed suicide or engaged in one or more non-lethal suicide attempts were less likely to die by suicide using a gun. Within the subsample of gun owning suicide decedents, a greater proportion of decedents who stored guns at home and in unsecure locations died from self-inflected gunshot wounds. These findings add clarity to the relationship between firearm ownership and death by suicide at the individual level. Furthermore, these findings are consistent with the notion that means safety implementation may represent a vital suicide prevention tool.

  4. Tumor site and disease stage as predictors of quality of life in head and neck cancer: a prospective study on patients treated with surgery or combined therapy with surgery and radiotherapy or radiochemotherapy.

    PubMed

    Veldhuis, Dennis; Probst, Gunther; Marek, Astrid; Noack, Volker; Ural, Ahmet; Adamietz, Irenaeus; Dazert, Stefan; Minovi, Amir

    2016-01-01

    In this prospective study, we compared the short-term quality of life (QOL) of two subgroups of head and neck cancers: oropharyngeal and laryngeal cancers. Patients treated with curative surgery, were asked to participate in the study using the EORTC QLQ-C30 and H&N35 questionnaires to examine QOL. The oropharynx group consisted of 32 (48 %) patients, while the larynx group consisted of 35 (52 %) patients. All patients were treated with either curative surgery alone or curative surgery combined with adjuvant radiotherapy or radiochemotherapy. The questionnaires were handed out pre- and post-therapy (10 months). At baseline, an impaired overall QOL (=EORTC QLQ-C30 global score) with a value of 53.4 for the whole patient collective was found; the overall QOL after 10 months improved (60.2, p < 0.05). Between the two patient groups, there was no difference in the global score after 10 months. The oropharynx patients described more problems with fatigue and oral cavity associated. The main symptoms in the larynx group were loss of sensual function and coughing. The present investigation revealed that the general post-therapy QOL in two subgroups of head and neck cancer reached a satisfying level.

  5. Energy Saving Melting and Revert Reduction Technology (E-SMARRT): Development of Surface Engineered Coating Systems for Aluminum Pressure Die Casting Dies: Towards a 'Smart' Die Coating

    SciTech Connect

    Dr. John J. Moore; Dr. Jianliang Lin,

    2012-07-31

    The main objective of this research program was to design and develop an optimal coating system that extends die life by minimizing premature die failure. In high-pressure aluminum die-casting, the die, core pins and inserts must withstand severe processing conditions. Many of the dies and tools in the industry are being coated to improve wear-resistance and decrease down-time for maintenance. However, thermal fatigue in metal itself can still be a major problem, especially since it often leads to catastrophic failure (i.e. die breakage) as opposed to a wear-based failure (parts begin to go out of tolerance). Tooling costs remain the largest portion of production costs for many of these parts, so the ability prevent catastrophic failures would be transformative for the manufacturing industry.The technology offers energy savings through reduced energy use in the die casting process from several factors, including increased life of the tools and dies, reuse of the dies and die components, reduction/elimination of lubricants, and reduced machine down time, and reduction of Al solder sticking on the die. The use of the optimized die coating system will also reduce environmental wastes and scrap parts. Current (2012) annual energy saving estimates, based on initial dissemination to the casting industry in 2010 and market penetration of 80% by 2020, is 3.1 trillion BTU's/year. The average annual estimate of CO2 reduction per year through 2020 is 0.63 Million Metric Tons of Carbon Equivalent (MM TCE).

  6. Accurate Die Design for Automotive Panel Stamping Considering the Compensation Related with Die Deflection and Blank Thinning

    NASA Astrophysics Data System (ADS)

    Chen, Jun; Xu, Dongkai; Xia, Guodong; Li, Xifeng; Chen, Jieshi; Zhang, Jian; Yan, Wei; Li, Yue

    2011-08-01

    In order to improve assembly accuracy, automotive body panels have to be fabricated with higher dimensional and surface quality requirements, therefore the die faces should be designed more accurately to consider more relevant factors. In the presented study, we proposed algorithms to realize the following functions: through forming process simulation, the thinning distribution on the deformed blank was extracted as first kind of compensation; through die structural CAE analysis which automatically mapped the boundary contact forces onto the die surfaces from process simulation results, the die deflection was calculated as second kind of compensation. These two quantitative contributions were added together to compensate the die face. The proposed methodologies were programmed and integrated with LS-Dyna and HyperWorks, and also integrated with Autoform and CATIA linear CAE functionalities separately. In addition, a software toolkit to calculate the contacting ratio was also developed to evaluate the effectiveness of die face compensation. The second toolkit developed was verified by an automotive structural part forming die design, through die compensation and geometric optimization, the predicted contact ratio between the die face and formed blank was improved a lot, and the first toolkit was testified by a fender drawing die design. It shows that the die face compensation can be realized and integrated seamlessly between CAD model, process simulation model and die structural CAE model with the help of data I/O tools developed by the authors.

  7. Method and apparatus for die forming metal sheets and extrusions

    NASA Astrophysics Data System (ADS)

    Darter, John L.

    1986-06-01

    The invention comprises an apparatus for die forming metal sheets and extrusions which utilizes die blocks of low melting temperature metallic material. The die blocks are formed in an adjustable mold which comprises a mold box, a pivotable dam within the mold box and blocking means for locking the pivotable dam member in a desired angular position. Once a desired die block angle is ascertained for a particular joggle, the pivotable member of the mold box is adjusted to produce the desired angle in the die casting made in the mold box.

  8. Sheet metal stamping die design for warm forming

    DOEpatents

    Ghosh, Amit K.

    2003-04-22

    In metal stamping dies, by taking advantage of improved material flow by selectively warming the die, flat sections of the die can contribute to the flow of material throughout the workpiece. Local surface heating can be accomplished by placing a heating block in the die. Distribution of heating at the flat lower train central regions outside of the bend region allows a softer flow at a lower stress to enable material flow into the thinner, higher strain areas at the bend/s. The heating block is inserted into the die and is powered by a power supply.

  9. Euthanasia, assisted dying and the right to die in Ghana: a socio-legal analysis.

    PubMed

    Owusu-Dapaa, Ernest

    2013-12-01

    There is unanimity among states to protect the continuation of life of the individual as a safeguard against their collective extinction. The right to life is accordingly guaranteed but its antithesis, the right to die is the subject of an unending debate. The controversy over the right to die is deepened by rapid advances in medicine, creating the capability for prolongation of life beyond the span which one's natural strength can endure. Ghana's supreme law explicitly guarantees the right to life but remains ambiguous on right to die, particularly euthanasia and assisted dying. Thus, some of the other rights, such as the right to dignity and not to be tortured, can creatively be exploited to justify some instances of euthanasia. Ghana's criminal code largely proscribes euthanasia. Notwithstanding, proscription of euthanasia and assisted dying by the law, in Ghana's empirical work undertaken in some of the communities in Ghana, suggests that euthanasia is quietly practisedin health facilities and private homes, especially in the rural areas. Contrary to the popular reasons assigned in the literature of the Western world, with respect to the practice or quest for legalization of euthanasia as being a necessity for providing relief from pain or hopeless quality of life, empirical data from social and anthropological studies conducted in Ghana reveal that poverty is the motivation for informal euthanasia practice in Ghana rather than genuine desire on part of patients to die or their relatives to see to their accelerated death. Apart from poverty, traditional cultural values of African societies consider non-natural death as a taboo and ignominy to the victim and his family. Thus, any move by the government to legalize euthanasia will need to be informed by widely held consultations and a possible referendum; otherwise the law may be just a mere transplant of Western models of legislation on euthanasia without reflecting the ethos of the African people.

  10. Dying cancer patients talk about euthanasia.

    PubMed

    Eliott, Jaklin A; Olver, Ian N

    2008-08-01

    Within developed nations, there is increasing public debate about and apparent endorsement of the appropriateness of euthanasia as an autonomous choice to die in the face of intolerable suffering. Surveys report socio-demographic differences in rates of acceptance of euthanasia, but there is little in-depth analysis of how euthanasia is understood and positioned within the social and moral lives of individuals, particularly those who might be considered suitable candidates-for example, terminally-ill cancer patients. During discussions with 28 such patients in Australia regarding medical decisions at the end of life, euthanasia was raised by 13 patients, with the others specifically asked about it. Twenty-four patients spoke positively of euthanasia, 19 of these voicing some concerns. None identified euthanasia as a currently favoured option. Four were completely against it. Endorsement for euthanasia was in the context of a hypothetical future or for a hypothetical other person, or temporally associated with acute pain. Arguments supporting euthanasia framed the issue as a matter of freedom of choice, as preserving dignity in death, and as curbing intolerable pain and suffering, both of the patient and of those around them. A common analogy featured was that of euthanising a dog. These arguments were typically presented as self-evident justification for euthanasia, construed as an appropriate choice to die, with opposers positioned as morally inferior or ignorant. The difficulties of ensuring 'choice' and the moral connotations of 'choosing to die,' however, worked to problematise the appropriateness of euthanising specific individuals. We recommend further empirical investigation of the moral and social meanings associated with euthanasia.

  11. Use of aerosol route to fabricate positively charged Au/Fe3O4 Janus nanoparticles as multifunctional nanoplatforms

    NASA Astrophysics Data System (ADS)

    Byeon, Jeong Hoon; Park, Jae Hong

    2016-10-01

    Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4 domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.

  12. Implementing California's Law on Assisted Dying.

    PubMed

    Mishra, Ruchika

    2017-03-01

    On October 5, 2015, Governor Jerry Brown approved bill ABX2 15, the End of Life Option Act, making California the fifth state in the country to allow physician-assisted dying. The law was modeled after Oregon's 1997 Death with Dignity Act. When the legislative special session ended on March 10, 2016, California health care providers had only ninety days to respond to the state mandate before the law would take effect, on June 9, 2016. Experience with the law so far suggests several challenges with implementation.

  13. Do imaginary companions die? An exploratory study.

    PubMed

    Kastenbaum, Robert; Fox, Lynn

    Adults in this exploratory study usually recalled that their childhood imaginary companions faded away or were dismissed as other options for social interaction became more appealing. However, eight participants reported that their IC had died. Analysis of these deaths offers a glimpse of the child's talent for transitional thought processes that navigate between the emerging constraints of logic and the continuing appeal of fantasy. It is suggested that young children are testing the limits and possibilities of what it means to be "real" at the same time they are trying to puzzle out "alive" and "dead."

  14. Die swell as an objective in the design of polymer extrusion dies

    NASA Astrophysics Data System (ADS)

    Siegbert, Roland; Behr, Marek; Elgeti, Stefanie

    2016-10-01

    This paper focuses on developing a suitable objective function for the inverse form of profile extrusion die design. First, the problem is motivated by introducing the extrusion die design process. After describing how Computer Aided Engineering enhances the traditional design process, a set of applicable objective functions is introduced. The main criteria for identifying the most suitable are computational applicability, robustness and smoothness of the functional. After discussing the results of several simulations, an objective function is proposed for the implementation in an existing optimization framework utilizing parameter-based optimization.

  15. DIE Deflection Modeling: Empirical Validation and Tech Transfer

    SciTech Connect

    R. Allen Miller

    2003-05-28

    This report summarizes computer modeling work that was designed to help understand how the die casting die and machine contribute to parting plane separation during operation. Techniques developed in earlier research (8) were applied to complete a large computational experiment that systematically explored the relationship between the stiffness of the machine platens and key dimensional and structural variables (platen area covered, die thickness, platen thickness, thickness of insert and the location of the die with respect to the platen) describing the die/machine system. The results consistently show that there are many significant interactions among the variables and it is the interactions, more than the individual variables themselves, which determine the performance of the machine/die system. That said, the results consistently show that it is the stiffness of the machine platens that has the largest single impact on die separation.

  16. Die-target for dynamic powder consolidation

    DOEpatents

    Flinn, J.E.; Korth, G.E.

    1985-06-27

    A die/target is disclosed for consolidation of a powder, especially an atomized rapidly solidified metal powder, to produce monoliths by the dynamic action of a shock wave, especially a shock wave produced by the detonation of an explosive charge. The die/target comprises a rectangular metal block having a square primary surface with four rectangular mold cavities formed therein to receive the powder. The cavities are located away from the geometrical center of the primary surface and are distributed around such center while also being located away from the geometrical diagonals of the primary surface to reduce the action of reflected waves so as to avoid tensile cracking of the monoliths. The primary surface is covered by a powder retention plate which is engaged by a flyer plate to transmit the shock wave to the primary surface and the powder. Spawl plates are adhesively mounted on other surfaces of the block to act as momentum traps so as to reduce reflected waves in the block. 4 figs.

  17. Die-target for dynamic powder consolidation

    DOEpatents

    Flinn, John E.; Korth, Gary E.

    1986-01-01

    A die/target is disclosed for consolidation of a powder, especially an atomized rapidly solidified metal powder, to produce monoliths by the dynamic action of a shock wave, especially a shock wave produced by the detonation of an explosive charge. The die/target comprises a rectangular metal block having a square primary surface with four rectangular mold cavities formed therein to receive the powder. The cavities are located away from the geometrical center of the primary surface and are distributed around such center while also being located away from the geometrical diagonals of the primary surface to reduce the action of reflected waves so as to avoid tensile cracking of the monoliths. The primary surface is covered by a powder retention plate which is engaged by a flyer plate to transmit the shock wave to the primary surface and the powder. Spawl plates are adhesively mounted on other surfaces of the block to act as momentum traps so as to reduce reflected waves in the block.

  18. The dying child and surviving family members.

    PubMed

    Shrier, D K

    1980-12-01

    This overview of death and dying focuses on the dying child and surviving family members. Children's concepts of death at different developmental stages are reviewed. These range from an inability to distinguish death from other forms of separation prior to age 3, through partial concepts of death until, by age 10 to 15 years, children are able to conceptualize death as universal, inevitable and final. The importance of adults assisting in the child's growing comprehension of death is stressed. The stages of grief and mourning, as outlined by Kubler-Ross, are reviewed from the perspective of the child and family: denial, anger, bargaining, depression and acceptance. Recognition is given to the variations in coping styles among different family members. The special circumstances related to the death of an infant and the impact of the death of a child on the surviving siblings are discussed. Specific helpful interventions to assist families in coping with mourning are described. The death of a child remains one of the most painful and difficult events for a family and its physician to accept.

  19. Dying or living?: The double bind.

    PubMed

    Longhofer, J

    1980-06-01

    Describing the behaviors of terminally ill patients, their families and those charged with their care has received considerable attention during the past decade. This study of comprehensive cancer treatment and research facility indicates that the prevailing theory is limited to explanation at the intra-psychic level. In her work with hundreds of terminal cases, Dr. Elizabeth Kubler-Ross found that patients typically progress through five stages: 1) denial, 2) anger, 3) bargaining, 4) depression, and 5) acceptance. She concludes that the majority of her patients die in a stage of acceptance--a state of equanimity. Recently, scholars have claimed that this five stage scheme has limited applicability and may in fact contribute to the formalization of a dying person's behavior. This preliminary report proposes that the stage theory, if it has any descriptive validity, becomes meaningful only when used to describe behaviors occurring among patients, families, and medical practitioners. A plausible explanation of these behaviors is accomplished by examination of communication patterns containing the structure of paradox or double bind. Patients are forced to perceive realities about their physical conditions not as they appear to them, but as they are defined by those in their environment. This paper explores these communication patterns in relation to the structure of social relationships and the specific contents of messages being transmitted and received.

  20. [The debate about the right to die].

    PubMed

    Beca, Juan Pablo; Ortiz, Armando; Solar, Sebastián

    2005-05-01

    The Right to Die is a debatable issue and some basic notions need to be clarified to discuss it. Death needs to be recognized as part of human life. The goal of medicine is to avoid pain and alleviate suffering, to prevent premature death and when this is not possible, to let it occur peacefully. The concept of euthanasia is unclear, which increases the confusion on end-of-life topics. The term euthanasia should be used only when referring to medical acts performed to produce the patient's death, with the intention of terminating his/her suffering. It is what is usually called "active" euthanasia, which can be voluntary or involuntary. It is essential to understand the difference between producing and allowing death. This will permit timely decisions about limiting or withdrawing treatments, that can be disproportionate or that are only prolonging suffering. Limiting treatments does not mean to abandon the patient but rather to redefine his needs, such as pain treatment, prevention of complications, and relief of suffering. The ethic rationale for these decisions is the respect to the dignity of human life, and the estimation of proportionality or futility of each treatment. The physician's duty with the patient at the end of his life is to assist him in dying according to his values and to minimize his distress.

  1. Dying, mourning, and spirituality: a psychological perspective.

    PubMed

    Marrone, R

    1999-09-01

    Based in an unfortunate tradition that stretches back in time to Watson's behaviorism and Freud's psychoanalysis, psychology has tended to reject and to pathologize matters of the spirit. In the past 30 years, however, with the advent of what has been termed the cognitive revolution, psychology has greatly expanded the scope of its subject matter. Psychologists and thanatologists have begun to unravel the cognitive underpinnings of our assumptive world and the transformation of those underpinnings in times of crisis and stress. This article examines the cognitive basis of the spiritual experience and the use of cognitive assimilation, accommodation strategies during the process of mourning the death of a loved one, as well as during the process of living our own dying. Of special importance to mental health professionals and clergy, new research on dying, mourning, and spirituality suggests that the specific ways in which people rediscover meaning--such as belief in traditional religious doctrine, the afterlife, reincarnation, philanthropy, or a spiritual order to the universe--may be less important than the process itself. In other words, in the midst of dealing with profound loss in our lives, the ability to reascribe meaning to a changed world through spiritual transformation, religious conversion, or existential change may be more significant than the specific content by which that need is filled.

  2. Die casting die deflections: Prediction and attenuation. Final report, July 1, 1995--September 30, 1997

    SciTech Connect

    Miller, R.Allen; Ahuett-Garza, Horacio; Choudhury, Aswin K.; Dedhia, Sanjay

    1998-05-01

    The objective of this work was to develop and test die casting design evaluation techniques based on the visualization of geometric data that is related to potential defects or problems. Specifically, thickness information is used to provide insight into potential thermal problems in the part and die. Distance from the gate and a special type of animation of the fill pattern is used to provide an assessment of gate, vent and overflow locations. Techniques have been developed to convert part design information in the form of STL files to a volume-based representation called a voxel model. The use of STL files makes the process CAD system independent. Once in voxel form, methods that were developed in this work are used to identify thick regions in the part, thin regions in the part and/or die, distance from user specified entry locations (gates), and the qualitative depiction of the fill pattern. The methods were tested with a prototype implementation on the UNIX platform. The results of comparisons with numerical simulation and field reported defects were surprisingly good. The fill-related methods were also compared against short-shots and a water analog study using high speed video. The report contains the results of the testing plus detailed background material on the construction of voxel models, the methods used for displaying results, and the computational geometric reasoning methods used to create die casting-related information from the voxel model for display to the user.

  3. [From absolute necessity of dying to preventive planning of dying? The change of social and medicine debates on dying in the 1980s].

    PubMed

    Jordan, I

    2010-04-01

    International euthanasia debates focussing on "autonomous dying" in the 1980s corresponded with a general change in the health-care system: availability of new technical means with an analogous medical-ethic understanding of human suffering and dying. This change is part of a general development from "passive health consumption" to "active prevention" in our society.

  4. Oxidative degradation of industrial wastewater using spray deposited TiO2/Au:Fe2O3 bilayered thin films.

    PubMed

    Mahadik, M A; Shinde, S S; Pathan, H M; Rajpure, K Y; Bhosale, C H

    2014-12-01

    The Fe2O3, Au:Fe2O3, TiO2/Fe2O3 and TiO2/Au:Fe2O3 thin films are successfully prepared by the spray pyrolysis technique at an optimised substrate temperature of 400 °C and 470 °C, respectively onto amorphous and F:SnO2 coated glass substrates. The effect of TiO2 layer onto photoelectrochemical (PEC), structural, optical and morphological properties of Fe2O3, Au:Fe2O3, TiO2/Fe2O3 and TiO2/Au:Fe2O3 thin films is studied. The PEC characterization shows that, maximum values of short circuit current (Isc) and open circuit voltage (Voc) are (Isc = 185 μA and Voc = 450 mV) are at 38 nm thickness of TiO2. Deposited films are polycrystalline with a rhombohedral and anatase crystal structure having (104) preferred orientation. SEM and AFM images show deposited thin films are compact and uniform with seed like grains. The photocatalytic activities of the large surface area (64 cm(2)) TiO2/Au:Fe2O3 thin film photocatalysts were evaluated by photoelectrocatalytic degradation of industrial wastewater under sunlight light irradiation. The results show that the TiO2/Au:Fe2O3 thin film photocatalyst exhibited about 87% and 94% degradation of pollutant in sugarcane and textile industrial wastewater, respectively. The significant reduction in COD and BOD values from 95 mg/L to 13 mg/L and 75 mg/L to 11 mg/L, respectively was also observed.

  5. The dying role: its relevance to improved patient care.

    PubMed

    Noyes, R; Clancy, J

    1977-02-01

    Society is failing to meet the obligation it has to its dying members. Persons with terminal illnesses suffer isolation and neglect in hospitals, receive overzealous treatment by physicians, and are kept in ignorance of their situation by families and medical personnel. Evidence for these statements has come from observers of the medical care system and from dying patients themselves (Kübler-Ross, 1969; Reynolds and Kalish, 1974; Sudnow, 1967); In the nineteenth century it was common for persons to die in the familiar environs of their homes, surrounded by grieving families from whom they parted in a meaningful manner (Blauner, 1966). Dying persons of today no longer fill a well-defined social role. Instead, the distinction between the roles of sick and dying persons has been lost and, in the resulting confusion, the care of dying people has suffered. The purpose of this article is to clarify the distinction between the dying and sick roles, identify the signs of existing role confusion, suggest ways in which this confusion may be corrected, and show how reestablishment of the dying role can result in improved care of dying people. The important part physicians play in defining sick and dying roles will be emphasized.

  6. The Dying Role: Its Relevance to Improved Patient Care.

    PubMed

    Noyes, Russell; Clancy, John

    2016-01-01

    SOCIETY is failing to meet the obligation it has to its dying members. Persons with terminal illnesses suffer isolation and neglect in hospitals, receive overzealous treatment by physicians, and are kept in ignorance of their situation by families and medical personnel. Evidence for these statements has come from observers of the medical care system and from dying patients themselves (Kübler-Ross, 1969; Reynolds and Kalish, 1974; Sudnow, 1967). In the nineteenth century it was common for persons to die in the familiar environs of their homes, surrounded by grieving families from whom they parted in a meaningful manner (Blauner, 1966). Dying persons of today no longer fill a well-defined social role. Instead, the distinction between the roles of sick and dying persons has been lost and, in the resulting confusion, the care of dying people has suffered. The purpose of this article is to clarify the distinction between the dying and sick roles, identify the signs of existing role confusion, suggest ways in which this confusion may be corrected, and show how reestablishment of the dying role can result in improved care of dying people. The important part physicians play in defining sick and dying roles will be emphasized.

  7. AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders

    PubMed Central

    2011-01-01

    Abstract RNA-binding proteins may regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability and translation of many genes. The dynamic association of these proteins with RNA defines the lifetime, cellular localization, processing and the rate at which a specific mRNA is translated. One of the pathways involved in regulating of mRNA stability is mediated by adenylate uridylate-rich element (ARE) binding proteins. These proteins are involved in processes of apoptosis, tumorigenesis and development. Out of many ARE-binding proteins, two of them AUF1 and HuR were studied most extensively and reported to regulate the mRNA stability in vivo. Our previously published data demonstrate that both proteins are involved in thyroid carcinogenesis. Several other reports postulate that mRNA binding proteins may participate in thyroid hormone actions. However, until now, exacts mechanisms and the possible role of post-transcriptional regulation and especially the role of AUF1 and HuR in those processes remain not fully understood. In this study we shortly review the possible function of both proteins in relation to development and various physiological and pathophysiological processes, including thyroid function and disorders. PMID:21835052

  8. Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

    PubMed Central

    Fragkouli, Apostolia; Koukouraki, Pelagia; Vlachos, Ioannis S.; Paraskevopoulou, Maria D.; Hatzigeorgiou, Artemis G.; Doxakis, Epaminondas

    2017-01-01

    Aβ peptide that accumulates in Alzheimer’s disease brain, derives from proteolytic processing of the amyloid precursor protein (APP) that exists in three main isoforms derived by alternative splicing. The isoform APP695, lacking exons 7 and 8, is predominately expressed in neurons and abnormal neuronal splicing of APP has been observed in the brain of patients with Alzheimer’s disease. Herein, we demonstrate that expression of the neuronal members of the ELAVL protein family (nELAVLs) correlate with APP695 levels in vitro and in vivo. Moreover, we provide evidence that nELAVLs regulate the production of APP695; by using a series of reporters we show that concurrent binding of nELAVLs to sequences located both upstream and downstream of exon 7 is required for its skipping, whereas nELAVL-binding to a highly conserved U-rich sequence upstream of exon 8, is sufficient for its exclusion. Finally, we report that nELAVLs block APP exon 7 or 8 definition by reducing the binding of the essential splicing factor U2AF65, an effect facilitated by the concurrent binding of AUF-1. Our study provides new insights into the regulation of APP pre-mRNA processing, supports the role for nELAVLs as neuron-specific splicing regulators and reveals a novel function of AUF1 in alternative splicing. PMID:28291226

  9. National Metal Casting Research Institute final report. Volume 2, Die casting research

    SciTech Connect

    Jensen, D.

    1994-06-01

    Four subprojects were completed: development and evaluation of die coatings, accelerated die life characterization of die materials, evaluation of fluid flow and solidification modeling programs, selection and characterization of Al-based die casting alloys, and influence of die materials and coatings on die casting quality.

  10. Necroptosis: A new way of dying?

    PubMed

    Hanson, Britt

    2016-09-01

    This review embarks upon a cell death journey from the discovery of apoptosis and necrosis through to the coalescence of these: necroptosis. The mechanisms of 2 emerging necrotic cell death pathways, pyroptosis and ferroptosis, will be explored before delving into apoptotic and necroptotic signaling cascades, highlighting the complex interplay between molecular players. The involvement of the ripoptosome, interferon signaling and DNA damage in necroptosis will be discussed briefly. The major focus is on necroptosis initiation by tumor necrosis factor-α (TNFα) and its cognate receptor TNFR1, caspase-independent RIP1/RIP3/MLKL necrosome activation and cell death propagation by damage-associated molecular pattern (DAMP) release. Finally, the implications of a complex cell death signaling network will be revealed in the context of cancer biology and therapy. The clinical contribution of the discovery of necroptosis as an unequivocally new way of dying is monumental and could drastically alter cancer therapy strategies in the future.

  11. HIV transcription is induced in dying cells

    SciTech Connect

    Woloschak, G.E.; Chang-Liu, Chin-Mei; Schreck, S. |; Panozzo, J.; Libertin, C.R.

    1996-02-01

    Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. Doses which caused over 99% cell killing induced HIV-LTR transcription maximally, demonstrating that cells that will go on to die by 14 days are the cells expressing HIV-LTR-CAT.

  12. Autonomy, rationality and the wish to die.

    PubMed Central

    Clarke, D M

    1999-01-01

    Although suicide has traditionally carried a negative sanction in Western societies, this is now being challenged, and while there remains substantial public concern surrounding youth and elder suicide, there is a paradoxical push to relax the prohibition under certain circumstances. Central to the arguments behind this are the principles of respect for autonomy and the importance of rationality. It is argued here that the concepts of rationality and autonomy, while valuable, are not strong enough to substantiate a categorical "right to suicide" and that the concepts of "understandability" and "respect" are more useful and able to provide the foundation for responding to a person expressing a wish to die. Roman suicide, sometimes held as an example of "rational suicide", illustrates the effects of culture, tradition and values on the attitudes to, and the practice of, suicide. PMID:10635498

  13. Paradoxical contributions of EEG during protracted dying.

    PubMed

    Spudis, E V; Penry, J K; Link, A S

    1984-02-01

    Estimates of the potential for recovery from severe brain damage have become more accurate as EEG and imaging techniques evolve. When all modern electrical criteria for brain death are satisfied, useful recovery is probably impossible. Many patients who have no reasonable chance of returning to a cognitive, sapient, or useful state may be nurtured throughout a prolonged final illness primarily because of brain waves that fluctuate in the 2- to 5-microV range. The incidence of such protracted dying is unknown. We illustrate diffuse low-amplitude wave forms and regional fragments recorded from a 27-year-old woman maintained on a respirator for six months after loss of brain-stem reflexes. Considering the limited noise-signal ratio of modern equipment, popular EEG criteria for death may be prematurely rigid, prolonging death in tragic circumstances.

  14. Death and dying anxiety among bereaved and nonbereaved elderly parents.

    PubMed

    Azaiza, Faisal; Ron, Pnina; Shoham, Meyrav; Tinsky-Roimi, Tal

    2011-08-01

    This study examines differences in death and dying anxiety between bereaved and nonbereaved elderly Israeli parents, as well as correlates of these factors among bereaved parents. A total of 97 parents (49 bereaved, 48 nonbereaved) completed measures of death and dying anxiety and religiosity. Bereaved parents reported significantly higher dying anxiety scores than nonbereaved parents, but there were no significant differences between the 2 groups in death anxiety. Religiosity was unrelated to death and dying anxiety. Dying anxiety was higher among bereaved mothers than bereaved fathers. Death and dying anxiety were not associated with the length of time since the loss of the child or the nature of the child's death. Results are discussed in light of the difficulties that bereaved parents experience after the loss of their child. Implications for theory, for health and welfare professionals, and for policy are suggested.

  15. Clinical Criteria for Physician Aid in Dying

    PubMed Central

    Pope, Thaddeus Mason; Rich, Ben A.

    2016-01-01

    Abstract More than 20 years ago, even before voters in Oregon had enacted the first aid in dying (AID) statute in the United States, Timothy Quill and colleagues proposed clinical criteria AID. Their proposal was carefully considered and temperate, but there were little data on the practice of AID at the time. (With AID, a physician writes a prescription for life-ending medication for a terminally ill, mentally capacitated adult.) With the passage of time, a substantial body of data on AID has developed from the states of Oregon and Washington. For more than 17 years, physicians in Oregon have been authorized to provide a prescription for AID. Accordingly, we have updated the clinical criteria of Quill, et al., based on the many years of experience with AID. With more jurisdictions authorizing AID, it is critical that physicians can turn to reliable clinical criteria. As with any medical practice, AID must be provided in a safe and effective manner. Physicians need to know (1) how to respond to a patient's inquiry about AID, (2) how to assess patient decision making capacity, and (3) how to address a range of other issues that may arise. To ensure that physicians have the guidance they need, Compassion & Choices convened the Physician Aid-in-Dying Clinical Criteria Committee, in July 2012, to create clinical criteria for physicians who are willing to provide AID to patients who request it. The committee includes experts in medicine, law, bioethics, hospice, nursing, social work, and pharmacy. Using an iterative consensus process, the Committee drafted the criteria over a one-year period. PMID:26539979

  16. HUBBLE SURVEYS DYING STARS IN NEARBY GALAXY

    NASA Technical Reports Server (NTRS)

    2002-01-01

    From ground-based telescopes, the glowing gaseous debris surrounding dying, sun-like stars in a nearby galaxy, called the Large Magellanic Cloud, appear as small, shapeless dots of light. But through the 'eyes' of NASA's Hubble Space Telescope, these bright dots take on a variety of shapes, from round- to pinwheel-shaped clouds of gas. Using Hubble's Space Telescope Imaging Spectrograph, scientists probed the glowing gas surrounding 27 dying stars, called planetary nebulae, in the Large Magellanic Cloud. The observations represent the most detailed study of planetary nebulae outside the Milky Way. The six objects in the picture illustrate the assortment of planetary nebulae identified in the galaxy. SMP 16, 30, and 93 are examples of a bipolar nebula, twin lobes of gas projecting away from a dying star. SMP 10 has a pinwheel shape and is known as a 'point-symmetric' nebula. SMP 4 has an elliptical appearance, and SMP 27, consisting of four lobes of gas, is called a 'quadrupolar' nebula. The lines point to the objects' locations in the Large Magellanic Cloud. A ground-based observatory snapped the picture of this galaxy. In the pictures of the planetary nebulae, color corresponds to temperature. Blue represents hotter regions of the nebulae and red, cooler. Scientists are probing these illuminated stellar relics in our neighboring galaxy because they are at relatively the same distance - about 168,000 light-years -- from Earth. Knowing the distance to these objects allows scientists to compare their shapes and sizes, and precisely determine the brightness of their central stars. For this reason, even though these glowing remains of dying stars are about 50 times farther away than the stunning planetary nebulae photographed in the Milky Way, they are of invaluable importance. By sampling this population, scientists noticed that the bipolar nebulae are richer in some heavier elements, such as neon, than those with a more spherical shape. At the dawn of the universe

  17. Thermal Hotspots in CPU Die and It's Future Architecture

    NASA Astrophysics Data System (ADS)

    Wang, Jian; Hu, Fu-Yuan

    Owing to the increasing core frequency and chip integration and the limited die dimension, the power densities in CPU chip have been increasing fastly. The high temperature on chip resulted by power densities threats the processor's performance and chip's reliability. This paper analyzed the thermal hotspots in die and their properties. A new architecture of function units in die - - hot units distributed architecture is suggested to cope with the problems of high power densities for future processor chip.

  18. L-connect routing of die surface pads to the die edge for stacking in a 3D array

    DOEpatents

    Petersen, Robert W.

    2000-01-01

    Integrated circuit chips and method of routing the interface pads from the face of the chip or die to one or more sidewall surfaces of the die. The interconnection is routed from the face of the die to one or more edges of the die, then routed over the edge of the die and onto the side surface. A new pad is then formed on the sidewall surface, which allows multiple die or chips to be stacked in a three-dimensional array, while enabling follow-on signal routing from the sidewall pads. The routing of the interconnects and formation of the sidewall pads can be carried out in an L-connect or L-shaped routing configuration, using a metalization process such as laser pantography.

  19. "Dying is dying, that's all": Structural violence and cultural projects in Malawian AIDS proverbs.

    PubMed

    Hayes, Nicole C

    2015-01-01

    This paper examines three Malawian proverbs about AIDS: "AIDS came for people", "Dying is dying, that's all" and "It's in the flour". Proverbs permit Malawians to discuss the otherwise taboo topic of AIDS because they offer a special register and perform a footing shift, a rhetorical manoeuvre that allows the speaker to attribute problematic speech to someone else. The proverbs under consideration convey a sense of powerless in the face of the AIDS epidemic, which is an indicator of the effects of structural violence on the everyday lives of most Malawians. Despite the aura of timeless tradition generally conveyed by proverbs, the author argues that individual Malawians are actually using AIDS proverbs to align themselves with the pursuit of gendered cultural projects, such as multiple concurrent partner sex and transactional sex, which are not traditional at all.

  20. Remote thermal neutron die-away measurements to improve Differential Die-Away Analysis

    NASA Astrophysics Data System (ADS)

    Jordan, Kelly A.; Vujic, Jasmina; Gozani, Tsahi

    2007-08-01

    Differential Die-away Analysis (DDAA) is a very effective detection technique of special nuclear material (SNM). It is based on the detection of fast fission neutrons that decay with a time constant characteristic of the thermal neutron that created them. The presence of fast neutrons with this slow die-away time is a positive, sensitive indication of the presence of SNM in the inspected cargo. The thermal decay time of an inspected medium is not known before a DDAA measurement is taken. The choice of when, from the end of a neutron pulse, data are to be acquired must be taken conservatively. If the thermal decay time of an inspected medium can be determined, a priori, then a better estimate of the expected time of separation between the intrinsic detector signal and the fission signal can be achieved. With a better estimate of this time, the choice of times after the end of the pulse to perform signal integration can be optimized. A more optimal choice for this time will result in higher detection sensitivity. This paper describes a method of remotely assessing the thermal die-away properties of an interrogated cargo, and grossly characterizes the class of material being inspected in terms of neutron attenuation and moderation properties.

  1. Bi-functional Au/FeS (Au/Co3O4) composite for in situ SERS monitoring and degradation of organic pollutants

    NASA Astrophysics Data System (ADS)

    Ma, Shuzhen; Cai, Qian; Lu, Kailing; Liao, Fan; Shao, Mingwang

    2016-01-01

    The bi-functional Au/FeS (Au/Co3O4) composite was fabricated by in situ reducing Au nanoparticles onto the surface of FeS (Co3O4). The as-prepared FeS possessed a multi-structure composed of plenty of nanoplates, which were coated by Au nanoparticles with an average size of 47.5 nm. While the Co3O4 showed a thin hexagonal sheet containing Au nanoparticles on its surface with an average size of 79.0 nm. Both the as-prepared Au/FeS and Au/Co3O4 composites exhibited excellent SERS performance, capable of enhancing the Raman signals of R6G molecules with the enhancement factor up to 1.81 × 106 and 7.60 × 104, respectively. Moreover, Au/FeS (Au/Co3O4) composite also has been verified to have intrinsic peroxidase-like activity, which could decompose H2O2 into hydroxyl radicals and then degrade organic pollutants into small molecules. Therefore, SERS can be used to real-time and in situ monitoring the degradation process of R6G molecules, employing the Au/FeS (Au/Co3O4) composite both as SERS substrate and catalyst.

  2. Regional ontogeny of New England salt marsh die-off.

    PubMed

    Coverdale, Tyler C; Bertness, Mark D; Altieri, Andrew H

    2013-10-01

    Coastal areas are among the world's most productive and highly affected ecosystems. Centuries of human activity on coastlines have led to overexploitation of marine predators, which in turn has led to cascading ecosystem-level effects. Human effects and approaches to mediating them, however, differ regionally due to gradients in biotic and abiotic factors. Salt marsh die-off on Cape Cod, Massachusetts (U.S.A.), triggered by a recreational-fishing-induced trophic cascade that has released herbivorous crabs from predator control, has been ongoing since 1976. Similar salt marsh die-offs have been reported in Long Island Sound and Narragansett Bay (U.S.A.), but the driving mechanism of these die-offs has not been examined. We used field experiments to assess trophic interactions and historical reconstructions of 24 New England marshes to test the hypotheses that recreational fishing and predator depletion are a regional trigger of salt marsh die-off in New England and that die-offs in Long Island Sound and Narragansett Bay are more recent than those on Cape Cod. Predator depletion was the general trigger of marsh die-off and explained differences in herbivorous crab abundance and the severity of die-off across regions. Die-offs in Long Island Sound and Narragansett Bay are following a trajectory similar to die-off on Cape Cod, but are approximately 20 years behind those on Cape Cod. As a result, die-off currently affects 31.2% (SE 2.2) of low-marsh areas in Long Island Sound and Narragansett Bay, less than half the severity of die-off on Cape Cod. Our results contribute to the growing evidence that recreational fishing is an increasing threat to coastal ecosystems and that studying the effects of human activity at regional scales can provide insight into local effects and aid in early detection and potential remediation.

  3. Use of aerosol route to fabricate positively charged Au/Fe3O4 Janus nanoparticles as multifunctional nanoplatforms

    PubMed Central

    Byeon, Jeong Hoon; Park, Jae Hong

    2016-01-01

    Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4 domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups. PMID:27713519

  4. Die Materials for Critical Applications and Increased Production Rates

    SciTech Connect

    David Schwam; John Wallace; Sebastian Birceanu

    2002-11-30

    Die materials for aluminum die-casting need to be resistant to heat checking, and have good resistance to washout and to soldering in a fast flow of molten aluminum. To resist heat checking, die materials should have a low coefficient of thermal expansion, high thermal conductivity, high hot yield strength, good temper softening resistance, high creep strength, and adequate ductility. To resist the washout and soldering, die materials should have high hot hardness, good temper resistance, low solubility in molten aluminum and good oxidation resistance. It is difficult for one material to satisfy with all above requirements. In practice, H13 steel is the most popular material for aluminum die casting dies. While it is not an ideal choice, it is substantially less expensive to use than alternative materials. However, in very demanding applications, it is sometimes necessary to use alternative materials to ensure a reasonable die life. Copper-base, nickel-base alloys and superalloys, titanium-,molybdenum-, tungsten-base alloys, and to some extent yttrium and niobium alloys, have all been considered as potential materials for demanding die casting applications. Most of these alloys exhibit superior thermal fatigue resistance, but suffer from other shortcomings.

  5. Potato Early Dying: Molecular Perspectives on Pathogenicity and Host Resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Potato early dying has not received the reputation of being a particularly devastating disease of potato. However, the interaction between the vascular fungus Verticillium dahliae and the root lesion nematode Pratylenchus penetrans to form the early dying complex makes studying this disease very in...

  6. Can We Humanize Dying in the General Hospital?

    ERIC Educational Resources Information Center

    Fleming, Stephen

    This paper reviews the literature on the behavior and attitudes of medical-nursing personnel toward the dying person and illustrates the frequent conflict between hospital staff and the needs of dying. Inner perturbation stemming from feelings of vicarious suffering, vicarious disintegration, or personal anxiety about death, education deficiencies…

  7. Optoelektronik Infrarotlicht für die Faseroptik

    NASA Astrophysics Data System (ADS)

    Drach, Volker

    2003-07-01

    Die Eigenschaften der kondensierten Materie sind durch die elektronische Bandstruktur bestimmt. Daher sind sie in Raumladungszonen an Oberflächen abhängig von der Ladungsdichte. Ein Team des Forschungszentrums Karlsruhe machte sich nun diesen Effekt zu Nutze und induzierte in metallischen Nanostrukturen durch eine elektrische Spannung reversible Änderungen der makroskopischen Eigenschaften [1].

  8. The Myriad Strategies for Seeking Control in the Dying Process

    ERIC Educational Resources Information Center

    Schroepfer, Tracy A.; Noh, Hyunjin; Kavanaugh, Melinda

    2009-01-01

    Purpose: This study explored the role control plays in the dying process of terminally ill elders by investigating the aspects of the dying process over which they seek to exercise control, the strategies they use, and whether they desire to exercise more control. Design and Methods: In-depth face-to-face interviews were conducted with 84…

  9. Death and Dying Anxiety among Elderly Arab Muslims in Israel

    ERIC Educational Resources Information Center

    Azaiza, Faisal; Ron, Pnina; Shoham, Meyrav; Gigini, Ibrahim

    2010-01-01

    Death and dying anxiety were examined among elderly Arab Muslims in Israel. A total of 145 people aged 60 and over were interviewed using a standardized questionnaire. Nursing home residents reported higher death anxiety than others; women and uneducated participants reported greater levels of fear of death and dying than others. There were no…

  10. Death and Dying Anxiety among Bereaved and Nonbereaved Elderly Parents

    ERIC Educational Resources Information Center

    Azaiza, Faisal; Ron, Pnina; Shoham, Meyrav; Tinsky-Roimi, Tal

    2011-01-01

    This study examines differences in death and dying anxiety between bereaved and nonbereaved elderly Israeli parents, as well as correlates of these factors among bereaved parents. A total of 97 parents (49 bereaved, 48 nonbereaved) completed measures of death and dying anxiety and religiosity. Bereaved parents reported significantly higher dying…

  11. A Study of the Training of Tool and Die Makers.

    ERIC Educational Resources Information Center

    Horowitz, Morris A.; Herrnstadt, Irwin L.

    To develop and test a methodology which would help determine the combination of education, training, and experience that is most likely to yield highly qualified workers in specific occupations, the tool and die maker trade was selected for examination in the Boston Metropolitan Area. Tool and die making was chosen because it is a clearly…

  12. Compassion in Dying v. State of Washington.

    PubMed

    1996-03-06

    The U.S. Court of Appeals for the Ninth Circuit, sitting en banc, affirmed a district court judgment that ruled unconstitutional a Washington statute banning assisted suicide, as applied to competent, terminally ill adults who wish to obtain prescription medication to hasten their deaths. The statute, which was challenged by a group of patients, physicians, and the nonprofit organization Compassion in Dying, was held to be unconstitutional because it violated the due process clause of the U.S. Constitution. The court took into consideration the interests of the state in protecting life, preventing suicides, preventing undue, arbitrary, or unfair influences on an individual's decision to end his life, and ensuring the integrity of the medical profession. These interests were balanced against an individual's strong liberty interest in determining how and when one's life should end. The court recognized this interest after assessing the growing public support for assisted suicide, changes in the causes of death and medical advances, and Supreme Court cases addressing due process liberty interests. The court then determined that the state's interest, which could be protected by adopting sufficient safeguards, did not outweigh the severe burden placed on the terminally ill, and thus the statute as applied was unconstitutional.

  13. Sonnet XXX: Love, dignity, and dying.

    PubMed

    Ely, E Wesley

    2016-05-01

    All of us in medicine who care for patients who are chronically critically ill, dying of incurable illnesses, will be faced with discussions about the value of their lives and about the appropriateness of ongoing supportive care. Such discussions are good and true, and they must always be done within the context of the sanctity of every human life and the promise of God that we are His children, each and every one of us. In this article, I explore the end-of-life path of a patient with amyotrophic lateral sclerosis (ALS) and the courageous faith that she demonstrated in the face of her illness. I explore with you, the reader, the hard-core conversations that took place at her bedside and their meaning in light of Catholic moral teaching. This story is not meant to indicate that we should always do all interventions at all times for all patients. That would be a teaching counter to Evangelium vitae. This story is meant to help you think through the path of your patients and of you as a physician or other type of healthcare professional in serving your patients. Primum non nocere. Ad majorem Dei gloriam.

  14. NICMOS PEERS INTO HEART OF DYING STAR

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Egg Nebula, also known as CRL 2688, is shown on the left as it appears in visible light with the Hubble Space Telescope's Wide Field and Planetary Camera 2 (WFPC2) and on the right as it appears in infrared light with Hubble's Near Infrared Camera and Multi-Object Spectrometer (NICMOS). Since infrared light is invisible to humans, the NICMOS image has been assigned colors to distinguish different wavelengths: blue corresponds to starlight reflected by dust particles, and red corresponds to heat radiation emitted by hot molecular hydrogen. Objects like the Egg Nebula are helping astronomers understand how stars like our Sun expel carbon and nitrogen -- elements crucial for life -- into space. Studies on the Egg Nebula show that these dying stars eject matter at high speeds along a preferred axis and may even have multiple jet-like outflows. The signature of the collision between this fast-moving material and the slower outflowing shells is the glow of hydrogen molecules captured in the NICMOS image. The distance between the tip of each jet is approximately 200 times the diameter of our solar system (out to Pluto's orbit). Credits: Rodger Thompson, Marcia Rieke, Glenn Schneider, Dean Hines (University of Arizona); Raghvendra Sahai (Jet Propulsion Laboratory); NICMOS Instrument Definition Team; and NASA Image files in GIF and JPEG format and captions may be accessed on the Internet via anonymous ftp from ftp.stsci.edu in /pubinfo.

  15. The right to die: beyond academia.

    PubMed

    Ramsey, Carole

    2016-03-01

    The world's first legal euthanasia death occurred in the Australian City of Darwin on Sunday 22 September 1996 when Bob Dent ended his life under the Northern Territory's short-lived Rights of the Terminally Ill Act 1995. Dent's death intensified argument about euthanasia in Australia, transforming the debate from a textbook discussion in social ethics into a vigorous and divisive social dispute. The day before he ended his life, Dent dictated a letter, written down by his wife. This description of his experience with terminal illness is graphic-the letter, his last effort to bring the plight of those living with terminal illness to public consciousness. In this paper I outline issues from the perspective of those, who like Bob Dent, the choice to die with dignity is personal and urgent. Rather than approach the issue purely from the theoretical, academic debate therefore, I present aspects that are largely unknown unless the experience of life-denying symptoms becomes real. From these aspects, dilemmas and consequences emerge that are not framed through the academic debate and in this way, I argue for the possibility of a framework that could change the law.

  16. Catholic theology and the "right to die".

    PubMed

    Coleman, G D

    1985-03-01

    Catholic moral theology teaches that life is sacred but not absolute. Because life and all activities are subordinated to spiritual ends, it is moral to allow oneself to die when efforts to prolong life will bring no significant benefit and may even make it more difficult to finish life in peace, composure, and union with God. This is not the moral equivalent of suicide, but rather an acceptance of the human condition. In making such a decision, the distinction between morally ordinary and extraordinary means is crucial and based on the patient's total good. Ordinary means are those which offer a reasonable hope of benefit without excessive expense, pain, or other inconvenience. Extraordinary means are those which cannot be obtained without excessive burden or which, if used, would not offer a reasonable hope of benefit. Whether a medical procedure is standard or experimental does not, from a moral viewpoint, affect whether it is ordinary or extraordinary. In Catholic teaching, the patient has the paramount right to decide whether life-preserving measures will be used. If the patient is unable to make this decision, then the family should make it as the patient's representative.

  17. [To die alone, a big city problem?].

    PubMed

    Smith, E; Larsen, D F; Rosdahl, N

    2001-05-28

    The question whether being found dead is a problem related to living in a big city was examined by using death certificates from a 3-month period in 1994. The rates of persons found dead were higher for both sexes in the City of Copenhagen than in the rural County of Storstrøm. The age distribution showed that the rate increased with advancing age. The vast majority were found dead in their own home, although the rate was higher in Copenhagen than in Storstrøm. Whereas the manner of death was natural for the majority of cases in both areas, more deaths with an uncertain manner of death were recorded in Copenhagen than in Storstrøm (32% vs 9%). In general, suicide or accident was more often reported in those found dead in the County of Storstrøm than in those in Copenhagen. The cause of death was unknown in 46% of deaths in Copenhagen where 16% had died from external causes, proportions that were 58% and 21%, respectively, in Storstrøm. The rate of legal autopsies was higher in subjects with an uncertain manner of death than in the rest, and was also associated with an age below 40 years. We conclude that being found dead is related to living in a big city, although the reason(s) for this remains unidentified.

  18. Including die and press deformations in sheet metal forming simulations

    NASA Astrophysics Data System (ADS)

    Pilthammar, Johan; Sigvant, Mats; Kao-Walter, Sharon

    2016-08-01

    Structural analysis, in Abaqus, of a stamping die and subsequent morphing of the tool surfaces in AutoForm were performed to improve a sheet metal forming simulation. First, the tool surfaces of the XC90 rear door inner were scanned. They were not matching when the die was unloaded and could therefore not give any satisfying results in sheet metal forming simulations. Scanned surface geometries were then added to a structural FE-model of the complete stamping die and some influential parts of the production press. The structural FE- model was analysed with Abaqus to obtain the structural deformations of the die. The calculated surface shapes were then transferred to AutoForm where a forming simulation was performed. Results from the different sheet metal forming simulations were compared to measured draw in curves and showed a substantial increase in accuracy and ability to analyse dies in running production when the morphed surfaces were used.

  19. De-tabooing dying control - a grounded theory study

    PubMed Central

    2013-01-01

    Background Dying is inescapable yet remains a neglected issue in modern health care. The research question in this study was “what is going on in the field of dying today?” What emerged was to eventually present a grounded theory of control of dying focusing specifically on how people react in relation to issues about euthanasia and physician-assisted suicide (PAS). Methods Classic grounded theory was used to analyze interviews with 55 laypersons and health care professionals in North America and Europe, surveys on attitudes to PAS among physicians and the Swedish general public, and scientific literature, North American discussion forum websites, and news sites. Results Open awareness of the nature and timing of a patient’s death became common in health care during the 1960s in the Western world. Open dying awareness contexts can be seen as the start of a weakening of a taboo towards controlled dying called de-tabooing. The growth of the hospice movement and palliative care, but also the legalization of euthanasia and PAS in the Benelux countries, and PAS in Montana, Oregon and Washington further represents de-tabooing dying control. An attitude positioning between the taboo of dying control and a growing taboo against questioning patient autonomy and self-determination called de-paternalizing is another aspect of de-tabooing. When confronted with a taboo, people first react emotionally based on “gut feelings” - emotional positioning. This is followed by reasoning and label wrestling using euphemisms and dysphemisms - reflective positioning. Rarely is de-tabooing unconditional but enabled by stipulated positioning as in soft laws (palliative care guidelines) and hard laws (euthanasia/PAS legislation). From a global perspective three shapes of dying control emerge. First, suboptimal palliative care in closed awareness contexts seen in Asian, Islamic and Latin cultures, called closed dying. Second, palliative care and sedation therapy, but not euthanasia

  20. Enhancements in Magnesium Die Casting Impact Properties

    SciTech Connect

    David Schwam; John F. Wallace; Yulong Zhu; Srinath Viswanathan; Shafik Iskander

    2000-06-30

    % in AM50 to over 9% in AZ91, more of the intermetallic Mg17Al12 is formed in the microstructure. For instance, for 15 increase in the aluminum content from AM50 to AM60, the volume fraction of eutectic present in the microstructure increases by 35%! Eventually, the brittle Mg17Al12 compound forms an interconnected network that reduces ductility and impact resistance. The lower aluminum in AM50 and AM60 are therefore a desirable feature in applications that call for higher impact resistance. Further improvement in impact resistance depends on the processing condition of the casting. Sound castings without porosity and impurities will have better mechanical properties. Since magnesium oxidizes readily, good melting and metal transfer practices are essential. The liquid metal has to be protected from oxidation at all times and entrainment of oxide films in the casting needs to be prevented. In this regard, there is evidence that us of vacuum to evacuate air from the die casting cavity can improve the quality of the castings. Fast cooling rates, leading to smaller grain size are beneficial and promote superior mechanical properties. Micro-segregation and banding are two additional defect types often encountered in magnesium alloys, in particular in AZ91D. While difficult to eliminate, segregation can be minimized by careful thermal management of the dies and the shot sleeve. A major source of segregation is the premature solidification in the shot sleeve. The primary solid dendrites are carried into the casting and form a heterogeneous structure. Furthermore, during the shot, segregation banding can occur. The remedies for this kind of defects include a hotter shot sleeve, use of insulating coatings on the shot sleeve and a short lag time between pouring into the shot sleeve and the shot.

  1. Optimization of Composition and Heat Treating of Die Steels for Extended Lifetime

    SciTech Connect

    David Schwam; John F. Wallace; Quanyou Zhou

    2002-01-30

    An ''average'' die casting die costs fifty thousand dollars. A die used in making die cast aluminum engine blocks can cost well over one million dollars. These costs provide a strong incentive for extension of die life. While vacuum quenched Premium Grade H13 dies have become the most widely used in the United States, tool makers and die casters are constantly searching for new steels and heat treating procedures to extend die life. This project was undertaken to investigate the effects of composition and heat treating on die life and optimize these parameters.

  2. [Why do Hungarian men die early?].

    PubMed

    Kopp, Mária; Skrabski, Arpád

    2009-09-01

    The mortality rate for 40- 69-year-old men was 12.2/thousand males of corresponding age in 1960 and 16.2 in 2005: it increased by 33%, while among 40- 69-year-old women it decreased from 9.6 0/thousand females of corresponding age to 7.8. The aim of the present follow up study was to analyze which psychosocial risk factors might explain the high premature mortality rates among Hungarian men. Participants in the Hungarostudy 2002 study, a nationally representative sample, 1130 men and 1529 women were contacted again in the follow up study in 2006, who in 2002 were between the age of 40-69 years. By 2006, 99 men (8.8%) and 53 women (3.5%) died in this age group. Socio-economic, psychosocial and work-related measures, self-rated health, chronic disorders, depressive symptoms (BDI), WHO well-being, negative affect, self-efficacy, meaning in life and health behavioral factors were included in the analysis. After adjustment according to smoking, alcohol abuse, BMI, education and age, a number of variables were significant predictors of mortality only in men: low education, low subjective social status, low personal and family income, insecurity of work, no control in work, severe depression, no meaning in life, low social support from spouse, low social support from child. Socio-economic and work related risk factors predicted only male premature death. Among women dissatisfaction with personal relations was the most important risk factor. Among men depression seems to mediate between these chronic stress factors and premature death.

  3. A DYING STAR IN GLOBULAR CLUSTER

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A DYING STAR IN GLOBULAR CLUSTER M15 The globular cluster Messier 15 is shown in this color image obtained with the NASA Hubble Space Telescope's Wide Field Planetary Camera 2 (WFPC2). Lying some 40,000 light-years from Earth in the direction of the constellation Pegasus, M15 is one of nearly 150 known globular clusters that form a vast halo surrounding our Milky Way galaxy. Each of these clusters is a spherical association of hundreds of thousands of ancient stars. The image, prepared by the Hubble Heritage team, attempts to show the stars in M15 in their true colors. The brightest cluster stars are red giants, with an orange color due to surface temperatures lower than our Sun's. Most of the fainter stars are hotter, giving them a bluish-white color. If we lived in the core of M15, our sky would blaze with tens of thousands of brilliant stars both day and night! Nestled among the myriads of stars visible in the Hubble image is an astronomical oddity. The pinkish object to the upper left of the cluster's core is a gas cloud surrounding a dying star. Known as Kuestner 648, this was the first planetary nebula to be identified in a globular cluster. In 1928, F. G. Pease, working at the 100-inch telescope of California's Mount Wilson Observatory, photographed the spectrum of K 648 and discovered the telltale bright emission of a nebular gas cloud rather than a normal star. In the ensuing 70 years, only three more planetary nebulae have been discovered in globular clusters. The stars in M15 and other globular clusters are estimated to be about 12 billion years old. They were among the first generations of stars to form in the Milky Way. Our Sun, by comparison, is a youthful 4.6 billion years old. As a star like the Sun ages, it exhausts the hydrogen that fuels its nuclear fusion, and increases in size to become a red giant. Then it ejects its outer layers into space, producing a planetary nebula. The remnant star at the center of the nebula gradually dies away as a

  4. A DYING STAR IN GLOBULAR CLUSTER

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A DYING STAR IN GLOBULAR CLUSTER M15 The globular cluster Messier 15 is shown in this color image obtained with the NASA Hubble Space Telescope's Wide Field Planetary Camera 2 (WFPC2). Lying some 40,000 light-years from Earth in the direction of the constellation Pegasus, M15 is one of nearly 150 known globular clusters that form a vast halo surrounding our Milky Way galaxy. Each of these clusters is a spherical association of hundreds of thousands of ancient stars. The image, prepared by the Hubble Heritage team, attempts to show the stars in M15 in their true colors. The brightest cluster stars are red giants, with an orange color due to surface temperatures lower than our Sun's. Most of the fainter stars are hotter, giving them a bluish-white color. If we lived in the core of M15, our sky would blaze with tens of thousands of brilliant stars both day and night! Nestled among the myriads of stars visible in the Hubble image is an astronomical oddity. The pinkish object to the upper left of the cluster's core is a gas cloud surrounding a dying star. Known as Kuestner 648, this was the first planetary nebula to be identified in a globular cluster. In 1928, F. G. Pease, working at the 100-inch telescope of California's Mount Wilson Observatory, photographed the spectrum of K 648 and discovered the telltale bright emission of a nebular gas cloud rather than a normal star. In the ensuing 70 years, only three more planetary nebulae have been discovered in globular clusters. The stars in M15 and other globular clusters are estimated to be about 12 billion years old. They were among the first generations of stars to form in the Milky Way. Our Sun, by comparison, is a youthful 4.6 billion years old. As a star like the Sun ages, it exhausts the hydrogen that fuels its nuclear fusion, and increases in size to become a red giant. Then it ejects its outer layers into space, producing a planetary nebula. The remnant star at the center of the nebula gradually dies away as a

  5. Compaction die for forming a solid annulus on a right circular cylinder. [Patent application

    DOEpatents

    Harlow, J.L.

    1981-09-14

    A compacting die is disclosed wherein the improvement comprises providing a screen in the die cavity, the screen being positioned parallel to the side walls of said die and dividing the die cavity into center and annular compartments. In addition, the use of this die in a method for producing an annular clad ceramic fuel material is disclosed.

  6. Understandings of death and dying for people of Chinese origin.

    PubMed

    Hsu, Chiung-yin; O'Connor, Margaret; Lee, Susan

    2009-02-01

    This article introduces the primary beliefs about ancestor worship, Taoism, Confucianism, Buddhism and traditional Chinese medicine that have influenced Chinese people for thousands of years, particularly in relation to death and dying. These cultures and traditions remain important for Chinese people wherever they live. Over a long period, Chinese people have integrated these philosophies and religions to form the basis of their culture and traditions. Although they agree that death is a natural part of the life span, a unique belief about death and dying has emerged among the Chinese from this integration. From this, the people find a significant definition of death and dying.

  7. Physikgeschichte Die Anfänge des Physik-Nobelpreises

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2003-09-01

    Durch Absorption von zwei Laserstrahlen mit unterschiedlichen Wellenlängen können in Halbleitern makroskopische Ströme erzeugt werden. Die Ausbreitungsrichtung der Elektronen und insbesondere die Ausrichtung ihrer Spins lassen sich über die relative Phase der beiden Laserfelder kohärent kontrollieren, wie kürzlich zwei Gruppen an den Universitäten von Marburg und Iowa demonstrierten [1, 2]. Genutzt wird bei diesem Experiment der Effekt der Quanteninterferenz zur Erzeugung von elektrischen Spinströmen.

  8. Experiences of Living and Dying With COPD

    PubMed Central

    Giacomini, M; DeJean, D; Simeonov, D; Smith, A

    2012-01-01

    Executive Summary In July 2010, the Medical Advisory Secretariat (MAS) began work on a Chronic Obstructive Pulmonary Disease (COPD) evidentiary framework, an evidence-based review of the literature surrounding treatment strategies for patients with COPD. This project emerged from a request by the Health System Strategy Division of the Ministry of Health and Long-Term Care that MAS provide them with an evidentiary platform on the effectiveness and cost-effectiveness of COPD interventions. After an initial review of health technology assessments and systematic reviews of COPD literature, and consultation with experts, MAS identified the following topics for analysis: vaccinations (influenza and pneumococcal), smoking cessation, multidisciplinary care, pulmonary rehabilitation, long-term oxygen therapy, noninvasive positive pressure ventilation for acute and chronic respiratory failure, hospital-at-home for acute exacerbations of COPD, and telehealth (including telemonitoring and telephone support). Evidence-based analyses were prepared for each of these topics. For each technology, an economic analysis was also completed where appropriate. In addition, a review of the qualitative literature on patient, caregiver, and provider perspectives on living and dying with COPD was conducted, as were reviews of the qualitative literature on each of the technologies included in these analyses. The Chronic Obstructive Pulmonary Disease Mega-Analysis series is made up of the following reports, which can be publicly accessed at the MAS website at: http://www.hqontario.ca/en/mas/mas_ohtas_mn.html. Chronic Obstructive Pulmonary Disease (COPD) Evidentiary Framework Influenza and Pneumococcal Vaccinations for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based Analysis Smoking Cessation for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based Analysis Community-Based Multidisciplinary Care for Patients With Stable Chronic Obstructive

  9. Characterization of Spray Lubricants for the Die Casting Process

    SciTech Connect

    Sabau, Adrian S

    2008-01-01

    During the die casting process, lubricants are sprayed in order to cool the dies and facilitate the ejection of the casting. The cooling effects of the die lubricant were investigated using Thermogravimetric analysis (TGA), heat flux sensors (HFS), and infrared imaging. The evolution of the heat flux and pictures taken using a high speed infrared camera revealed that lubricant application was a transient process. The short time response of the HFS allows the monitoring and data acquisition of the surface temperature and heat flux without additional data processing. A similar set of experiments was performed with deionized water in order to assess the lubricant effect. The high heat flux obtained at 300 C was attributed to the wetting and absorbant properties of the lubricant. Pictures of the spray cone and lubricant flow on the die were also used to explain the heat flux evolution.

  10. Warum Normen für die Instandhaltung?

    NASA Astrophysics Data System (ADS)

    Tschuschke, Werner E.

    Viele kennen Normen wie Konstruktionsnormen, in denen z. B. der Außendurchmesser, die Steigung, der Flankenwinkel und andere Maße eines Gewindes festgelegt sind. Es gibt Prüfnormen aber auch Normen eines Managementsystems wie des Qualitätsmanagements in der DIN-EN-ISO-9000-Familie. Aber warum Normen für die Instandhaltung? Begonnen hat es mit der DIN 31051, die 1985 veröffentlicht wurde. Es war die erste Instandhaltungsnorm weltweit und sie wurde von der Schweiz und Österreich übernommen. In ihr sind Begriffe der Instandhaltung, Grundlagen zum Abnutzungsprozess und Aktivitäten der Instandhaltung beschrieben. Es wurde der Begriff Instandsetzung statt Reparatur publiziert: Nicht mehr Flickschustern sondern einen funktionsfähigen Anlagenzustand möglichst erhalten.

  11. 8. INTERIOR BEADED WALL BOARDING SHOWING TRIAL MARKS FROM DIES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. INTERIOR BEADED WALL BOARDING SHOWING TRIAL MARKS FROM DIES MADE IN CARPENTER'S SHOP Ph: Jack E, Boucher - March 1961 - Joseph Carpenter Silversmith Shop, 71 East Town Street, Norwichtown, New London County, CT

  12. Method and Apparatus for Die Forming Metal Sheets and Extrusions.

    DTIC Science & Technology

    of a variety of die blocks for introducing a variety of angled joggles in the metal sheets and extrusions. Relatively low melting temperature material is used for the castings. Keywords: Patents; Aircraft parts. (kt)

  13. MICROORGANISMS DIE-OFF RATES IN URBAN STORMWATER RUNOFF 2007

    EPA Science Inventory

    Stormwater best management practices (BMPs) are often considered effective tools to mitigate the effects of stormwater pollutants before they are discharged to receiving waters. However, BMP performance for microorganisms removal is not well documented. Microorganisms die-off in...

  14. MICROORGANISMS DIE-OFF RATES IN URBAN STORMWATER RUNOFF 2007

    EPA Science Inventory

    Stormwater best management practices (BMPs) are often considered effective tools to mitigate the effects of stormwater pollutants before they are discharged to receiving waters. However, BMP performance for microorganisms removal is not well documented. Microorganisms die-off in ...

  15. Chemical strategies for die/wafer submicron alignment and bonding.

    SciTech Connect

    Martin, James Ellis; Baca, Alicia I.; Chu, Dahwey; Rohwer, Lauren Elizabeth Shea

    2010-09-01

    This late-start LDRD explores chemical strategies that will enable sub-micron alignment accuracy of dies and wafers by exploiting the interfacial energies of chemical ligands. We have micropatterned commensurate features, such as 2-d arrays of micron-sized gold lines on the die to be bonded. Each gold line is functionalized with alkanethiol ligands before the die are brought into contact. The ligand interfacial energy is minimized when the lines on the die are brought into registration, due to favorable interactions between the complementary ligand tails. After registration is achieved, standard bonding techniques are used to create precision permanent bonds. We have computed the alignment forces and torque between two surfaces patterned with arrays of lines or square pads to illustrate how best to maximize the tendency to align. We also discuss complex, aperiodic patterns such as rectilinear pad assemblies, concentric circles, and spirals that point the way towards extremely precise alignment.

  16. Cost analysis of medical assistance in dying in Canada

    PubMed Central

    Trachtenberg, Aaron J.; Manns, Braden

    2017-01-01

    BACKGROUND: The legalization of medical assistance in dying will affect health care spending in Canada. Our aim was to determine the potential costs and savings associated with the implementation of medical assistance in dying. METHODS: Using published data from the Netherlands and Belgium, where medically assisted death is legal, we estimated that medical assistance in dying will account for 1%–4% of all deaths; 80% of patients will have cancer; 50% of patients will be aged 60–80 years; 55% will be men; 60% of patients will have their lives shortened by 1 month; and 40% of patients will have their lives shortened by 1 week. We combined current mortality data for the Canadian population with recent end-of-life cost data to calculate a predicted range of savings associated with the implementation of medical assistance in dying. We also estimated the direct costs associated with offering medically assisted death, including physician consultations and drug costs. RESULTS: Medical assistance in dying could reduce annual health care spending across Canada by between $34.7 million and $138.8 million, exceeding the $1.5–$14.8 million in direct costs associated with its implementation. In sensitivity analyses, we noted that even if the potential savings are overestimated and costs underestimated, the implementation of mdedical assistance in dying will likely remain at least cost neutral. INTERPRETATION: Providing medical assistance in dying in Canada should not result in any excess financial burden to the health care system, and could result in substantial savings. Additional data on patients who choose medical assistance in dying in Canada should be collected to enable more precise estimates of the impact of medically assisted death on health care spending and to enable further economic evaluation. PMID:28246154

  17. Consortia for Known Good Die (KGD). Phase 1

    DTIC Science & Technology

    1994-02-01

    were being actively developed for test and bum-in of bare die or minimally packaged die. The companies plan to make the technology available to the...lifetime (up to the consensus single best technology for making temporary 1000 cycle limit) reducing cost. Cost impact of caner probe contact to...model and develop the system specification for Im oe _ side 40O extensions to make this a useful tool for industrial users 2 CPU 10 mm on each side 2001

  18. Microstructures and properties of aluminum die casting alloys

    SciTech Connect

    M. M. Makhlouf; D. Apelian; L. Wang

    1998-10-01

    This document provides descriptions of the microstructure of different aluminum die casting alloys and to relate the various microstructures to the alloy chemistry. It relates the microstructures of the alloys to their main engineering properties such as ultimate tensile strength, yield strength, elongation, fatigue life, impact resistance, wear resistance, hardness, thermal conductivity and electrical conductivity. Finally, it serves as a reference source for aluminum die casting alloys.

  19. Herbivory drives the spread of salt marsh die-off.

    PubMed

    Bertness, Mark D; Brisson, Caitlin P; Bevil, Matthew C; Crotty, Sinead M

    2014-01-01

    Salt marsh die-off is a Western Atlantic conservation problem that has recently spread into Narragansett Bay, Rhode Island, USA. It has been hypothesized to be driven by: 1) eutrophication decreasing plant investment into belowground biomass causing plant collapse, 2) boat wakes eroding creek banks, 3) pollution or disease affecting plant health, 4) substrate hardness controlling herbivorous crab distributions and 5) trophic dysfunction releasing herbivorous crabs from predator control. To distinguish between these hypotheses we quantified these variables at 14 Narragansett Bay salt marshes where die-off intensity ranged from <5% to nearly 98%. Nitrogen availability, wave intensity and plant growth did not explain any variation in die-off. Herbivory explained 73% of inter-site variation in die-off and predator control of herbivores and substrate hardness also varied significantly with die-off. This suggests that salt marsh die-off is being largely driven by intense herbivory via the release of herbivorous crabs from predator control. Our results and those from other marsh systems suggest that consumer control may not simply be a factor to consider in marsh conservation, but with widespread predator depletion impacting near shore habitats globally, trophic dysfunction and runaway consumption may be the largest and most urgent management challenge for salt marsh conservation.

  20. SiC Die Attach for High-Temperature Applications

    NASA Astrophysics Data System (ADS)

    Drevin-Bazin, A.; Lacroix, F.; Barbot, J.-F.

    2013-11-01

    Eutectic solders AuIn19 and AuGe12 and nanosilver paste were investigated for SiC die attach in high-temperature (300°C) applications. The soldering or sintering conditions were optimized through die shear tests performed at room temperature. In particular, application of static pressure (3.5 MPa) during sintering resulted in greatly improved mechanical behavior of the nanosilver-based joint. Microstructural study of the eutectic solders showed formation of Au-rich grains in AuGe die attach and significant diffusion of Au and In through the Ni layer in AuIn19 die attach, which could lead to formation of intermetallic compounds. Die shear tests versus temperature showed that the behaviors of the studied die attaches are different; nevertheless they present suitable shear strengths required for high-temperature applications. The mechanical behavior of joints under various levels of thermal and mechanical stress was also studied. Creep experiments were carried out on the eutectic solders to describe the thermomechanical behavior of the complete module; only one creep mechanism was observed in the working range.

  1. Dying while living: a critique of allowing-to-die legislation.

    PubMed Central

    Lappé, M

    1978-01-01

    Several US states are enacting 'right-to-die' laws, in the wake of the Karen Quinlan case. But the way such a law is drafted may cast doubt on a patient's existing common law right to control all aspects of his own treatment; it may give legal sanction to a lower standard of medical care that society at present expects from doctors; and it may lead to conflict between the patient's directive and his doctor's clinical judgement which cannot readily be resolved. The laws themselves are categorised as a) legalising active killing or b) defining rights of patients to control treatment or c) assigning to others the rights to control treatment where the patient is not competent. The California law is discussed critically. The conclusion is that such legislation is not a satisfactory answer to the ethical problem of euthanasia. PMID:739516

  2. Grote Reber, Radio Astronomy Pioneer, Dies

    NASA Astrophysics Data System (ADS)

    2002-12-01

    Grote Reber, one of the earliest pioneers of radio astronomy, died in Tasmania on December 20, just two days shy of his 91st birthday. Reber was the first person to build a radio telescope dedicated to astronomy, opening up a whole new "window" on the Universe that eventually produced such landmark discoveries as quasars, pulsars and the remnant "afterglow" of the Big Bang. His self- financed experiments laid the foundation for today's advanced radio-astronomy facilities. Grote Reber Grote Reber NRAO/AUI photo "Radio astronomy has changed profoundly our understanding of the Universe and has earned the Nobel Prize for several major contributions. All radio astronomers who have followed him owe Grote Reber a deep debt for his pioneering work," said Dr. Fred Lo, director of the National Radio Astronomy Observatory (NRAO). "Reber was the first to systematically study the sky by observing something other than visible light. This gave astronomy a whole new view of the Universe. The continuing importance of new ways of looking at the Universe is emphasized by this year's Nobel Prizes in physics, which recognized scientists who pioneered X-ray and neutrino observations," Lo added. Reber was a radio engineer and avid amateur "ham" radio operator in Wheaton, Illinois, in the 1930s when he read about Karl Jansky's 1932 discovery of natural radio emissions coming from outer space. As an amateur operator, Reber had won awards and communicated with other amateurs around the world, and later wrote that he had concluded "there were no more worlds to conquer" in radio. Learning of Jansky's discovery gave Reber a whole new challenge that he attacked with vigor. Analyzing the problem as an engineer, Reber concluded that what he needed was a parabolic-dish antenna, something quite uncommon in the 1930s. In 1937, using his own funds, he constructed a 31.4-foot-diameter dish antenna in his back yard. The strange contraption attracted curious attention from his neighbors and became

  3. The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts

    PubMed Central

    Hendrayani, Siti-Fauziah; Al-Harbi, Bothaina; Al-Ansari, Mysoon M.; Silva, Gabriela; Aboussekhra, Abdelilah

    2016-01-01

    The IL-6/STAT3/NF-κB positive feedback loop links inflammation to cancer and maintains cells at a transformed state. Similarly, cancer-associated myofibroblats remains active even in absence of cancer cells. However, the molecular basis of this sustained active state remains elusive. We have shown here that breast cancer cells and IL-6 persistently activate breast stromal fibroblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop. Transient neutralization of IL-6 in culture inhibited this signaling circuit and reverted myofibrobalsts to a normalized state, suggesting the implication of the IL-6 autocrine feedback loop as well. Importantly, the IL-6/STAT3/NF-κB pro-inflammatory circuit was also active in cancer-associated fibroblasts isolated from breast cancer patients. Transient inhibition of STAT3 by specific siRNA in active fibroblasts persistently reduced the level of the RNA binding protein AUF1, blocked the loop and normalized these cells. Moreover, we present clear evidence that AUF1 is also part of this positive feedback loop. Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1. These results indicate that the IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and is responsible for the sustained active status of cancer-associated fibroblasts. We have also shown that normalizing myofibroblasts, which could be of great therapeutic value, is possible through the inhibition of this procarcinogenic circuit. PMID:27248826

  4. Estimating the spatial distribution of acute undifferentiated fever (AUF) and associated risk factors using emergency call data in India. A symptom-based approach for public health surveillance.

    PubMed

    Kauhl, Boris; Pilot, Eva; Rao, Ramana; Gruebner, Oliver; Schweikart, Jürgen; Krafft, Thomas

    2015-01-01

    The System for Early-warning based on Emergency Data (SEED) is a pilot project to evaluate the use of emergency call data with the main complaint acute undifferentiated fever (AUF) for syndromic surveillance in India. While spatio-temporal methods provide signals to detect potential disease outbreaks, additional information about socio-ecological exposure factors and the main population at risk is necessary for evidence-based public health interventions and future preparedness strategies. The goal of this study is to investigate whether a spatial epidemiological analysis at the ecological level provides information on urban-rural inequalities, socio-ecological exposure factors and the main population at risk for AUF. Our results displayed higher risks in rural areas with strong local variation. Household industries and proximity to forests were the main socio-ecological exposure factors and scheduled tribes were the main population at risk for AUF. These results provide additional information for syndromic surveillance and could be used for evidence-based public health interventions and future preparedness strategies.

  5. Exciting Message from a Dying Monster Star

    NASA Astrophysics Data System (ADS)

    1996-03-01

    this is radiation from a SiO maser in the atmosphere of the star. If it would not have been a maser, it would have been far too weak to have been detected. Although we know several hundred masers of this type in the Milky Way, this is the first discovery of a SiO maser in another galaxy than our own . Since then, the observations have been continued in collaboration with Australian astronomers, using radio telescopes at Parkes and Mopra on that continent. A most unusual star When Swedish astronomer Bengt Westerlund and his colleagues first observed this LMC maser star in 1981 with optical telescopes, they thought that it was a rather normal, cool and not particularly bright star. However, a few years later, the Dutch-British-USA InfraRed Astronomical Satellite (IRAS) revealed its true nature. The IRAS measurements showed that the star radiates most of its light in the form of infrared radiation [4], making it one of the most powerful stars in the LMC; in fact, it emits about half a million times more energy than the Sun. On this occasion, it was given the designation IRAS 04553-6825 , the number indicating its position in the sky. IRAS 04553-6825 is unusual in other ways. It is some fifty times as heavy as our Sun, and it is the biggest known star in the LMC: if it were to take the place of our Sun, it would fill the solar system out to the planet Neptune, thirty times the distance from the Earth to the Sun. It is rather cool when compared to other stars - although it still has a temperature of about 2,000 C - and it therefore has a very red colour [5]. This Press Release is accompanied by ESO Press Photo 15/96 which demonstrates that while the star is hardly visible in blue light, it shines brightly in red and infrared light. Stars like IRAS 04553-6825 are known as red supergiants. It has been unofficially dubbed `The Monster', and having reached the end of a short and hectic life, it is now dying. The nuclear reactions deep inside are undergoing important changes at

  6. Exchange bias effect in Au-Fe3O4 dumbbell nanoparticles induced by the charge transfer from gold

    SciTech Connect

    Feygenson, Mikhail; Bauer, John C.; Gai, Zheng; Marques, Carlos; Aronson, Meigan C.; Teng, Xiaowei; Su, Dong; Stanic, Vesna; Urban, Volker S.; Beyer, Kevin A.; Dai, Sheng

    2015-08-10

    We have studied the origin of the exchange bias effect in the Au-Fe3O4 dumbbell nanoparticles in two samples with different sizes of the Au seed nanoparticles (4.1 and 2.7 nm) and same size of Fe3O4 nanoparticles (9.8 nm). The magnetization, small-angle neutron-scattering, synchrotron x-ray diffraction, and scanning transmission electron microscope measurements determined the antiferromagnetic FeO wustite phase within Fe3O4 nanoparticles, originating at the interface with the Au nanoparticles. The interface between antiferromagnetic FeO and ferrimagnetic Fe3O4 is giving rise to the exchange bias effect. The strength of the exchange bias fields depends on the interfacial area and lattice mismatch between both phases. We propose that the charge transfer from the Au nanoparticles is responsible for a partial reduction of the Fe3O4 into the FeO phase at the interface with Au nanoparticles. The Au-O bonds are formed, presumably across the interface to accommodate an excess of oxygen released during the reduction of magnetite

  7. Exchange bias effect in Au-Fe3O4 dumbbell nanoparticles induced by the charge transfer from gold

    DOE PAGES

    Feygenson, Mikhail; Bauer, John C; Gai, Zheng; ...

    2015-08-10

    We have studied the origin of the exchange bias effect in the Au-Fe3O4 dumbbell nanoparticles in two samples with different sizes of the Au seed nanoparticles (4.1 and 2.7 nm) and same size of Fe3O4 nanoparticles (9.8 nm). The magnetization, small-angle neutron scattering, synchrotron x-ray diffraction and scanning transmission electron microscope measurements determined the antiferromagnetic FeO wüstite phase within Fe3O4 nanoparticles, originating at the interface with the Au nanoparticles. The interface between antiferromagnetic FeO and ferrimagnetic Fe3O4 is giving rise to the exchange bias effect. The strength of the exchange bias fields depends on the interfacial area and lattice mismatchmore » between both phases. We propose that the charge transfer from the Au nanoparticles is responsible for a partial reduction of the Fe3O4 into FeO phase at the interface with Au nanoparticles. The Au-O bonds are formed across the interface to accommodate an excess of oxygen released during the reduction of magnetite.« less

  8. Ultrasensitive electrochemical detection of DNA hybridization using Au/Fe3O4 magnetic composites combined with silver enhancement.

    PubMed

    Bai, Yu-Hui; Li, Jin-Yi; Xu, Jing-Juan; Chen, Hong-Yuan

    2010-07-01

    A novel method is described for the highly effective amplifying electrochemical response of DNA based on oligonucleotides functionalized with Au/Fe(3)O(4) nanocomposites by the aid of silver (Ag) enhancement. Via electrostatic layer-by-layer (LBL) assembly, the prepared Fe(3)O(4) nanoparticles form nano-clusters coated with a bilayer composed of polystyrene sulfonate sodium salt (PSS) and poly(diallyldimethylammonium chloride) (PDDA), which are in favor of adsorbing lots of gold nanoparticles (AuNPs) on the surface. The application of magnetic Fe(3)O(4) made the procedures much more simple, convenient and feasible. The resulting composites were then used as labels via the Au-S bond for the DNA hybridization, followed by catalytic deposition of silver on the gold tags. Such an assay is then combined with a sensitive anodic stripping voltammetry (ASV) measurement of multiple silver nanoparticle tracers. A 27-mer sequence DNA target is detected at a glassy carbon (GC) electrode with a detection limit down to ca. 100 aM, which is 800 times lower than that obtained using gold nanoparticles only as labels in the control experiments. This Fe(3)O(4)/PSS/PDDA/Au composite offers a great promising future for the ultrasensitive detection of other biorecognition events.

  9. Kongenitale Chagas. Einfluss einer Trypanosoma Cruzi-Infektion auf die Embryonalentwicklung bei Traechtigen Maeusen (Congenital Chagas Diseases. Effect of ’Trypanosoma cruzi’ Infection on Embryogeny in Gravid Mice),

    DTIC Science & Technology

    Congenital Chagas’ disease in man and animals entailing abortion , premature delivery and deformation has been reported in the literature, although...the effect of T. cruzi infection on the fetal development of mice has been investigated after inoculating three different strains of T. cruzi in...in either early death or retarded growth of the embryos and fetuses, although trypanosomes were not demonstrable in injured fetuses (however

  10. Auf dem Weg zu einem neuen Weltcurriculum? Zum Grundbildungskonzept von PISA und der Aufgabenzuweisung an die Schule (Towards a World Curriculum? -- The Concept of Basic Education (Literacy) underlying PISA and the tasks allocated to Schooling).

    ERIC Educational Resources Information Center

    Fuchs, Hans-Werner

    2003-01-01

    Recognizes that the debate on the Program for International Student Assessment 2000 (PISA) has been dominated by comparisons of the ranks achieved and by the question of the consequences to be drawn from the results. Discusses the educational concept forming the basis for the investigation and aims of PISA. (CAJ)

  11. Phagocytosis of dying tumor cells by human peritoneal mesothelial cells.

    PubMed

    Wagner, Britta Janina; Lindau, Dennis; Ripper, Dagmar; Stierhof, York-Dieter; Glatzle, Jörg; Witte, Maria; Beck, Henning; Keppeler, Hildegard; Lauber, Kirsten; Rammensee, Hans-Georg; Königsrainer, Alfred

    2011-05-15

    Peritoneal carcinomatosis is an advanced form of metastatic disease characterized by cancer cell dissemination onto the peritoneum. It is commonly observed in ovarian and colorectal cancers and is associated with poor patient survival. Novel therapies consist of cytoreductive surgery in combination with intraperitoneal chemotherapy, aiming at tumor cell death induction. The resulting dying tumor cells are considered to be eliminated by professional as well as semi-professional phagocytes. In the present study, we have identified a hitherto unknown type of 'amateur' phagocyte in this environment: human peritoneal mesothelial cells (HMCs). We demonstrate that HMCs engulf corpses of dying ovarian and colorectal cancer cells, as well as other types of apoptotic cells. Flow cytometric, confocal and electron microscopical analyses revealed that HMCs ingest dying cell fragments in a dose- and time-dependent manner and the internalized material subsequently traffics into late phagolysosomes. Regarding the mechanisms of prey cell recognition, our results show that HMCs engulf apoptotic corpses in a serum-dependent and -independent fashion and quantitative real-time PCR (qRT-PCR) analyses revealed that diverse opsonin receptor systems orchestrating dying cell clearance are expressed in HMCs at high levels. Our data strongly suggest that HMCs contribute to dying cell removal in the peritoneum, and future studies will elucidate in what manner this influences tumor cell dissemination and the antitumor immune response.

  12. Acceptance of dying: a discourse analysis of palliative care literature.

    PubMed

    Zimmermann, Camilla

    2012-07-01

    The subject of death denial in the West has been examined extensively in the sociological literature. However, there has not been a similar examination of its "opposite", the acceptance of death. In this study, I use the qualitative method of discourse analysis to examine the use of the term "acceptance" of dying in the palliative care literature from 1970 to 2001. A Medline search was performed by combining the text words "accept or acceptance" with the subject headings "terminal care or palliative care or hospice care", and restricting the search to English language articles in clinical journals discussing acceptance of death in adults. The 40 articles were coded and analysed using a critical discourse analysis method. This paper focuses on the theme of acceptance as integral to palliative care, which had subthemes of acceptance as a goal of care, personal acceptance of healthcare workers, and acceptance as a facilitator of care. For patients and families, death acceptance is a goal that they can be helped to attain; for palliative care staff, acceptance of dying is a personal quality that is a precondition for effective practice. Acceptance not only facilitates the dying process for the patient and family, but also renders care easier. The analysis investigates the intertextuality of these themes with each other and with previous texts. From a Foucauldian perspective, I suggest that the discourse on acceptance of dying represents a productive power, which disciplines patients through apparent psychological and spiritual gratification, and encourages participation in a certain way to die.

  13. 9 CFR 325.20 - Transportation and other transactions concerning dead, dying, disabled, or diseased livestock...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of livestock that died... other transactions concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of... transporting in commerce, or importing any dead, dying, disabled or diseased animals or parts of the...

  14. 9 CFR 325.20 - Transportation and other transactions concerning dead, dying, disabled, or diseased livestock...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of livestock that died... other transactions concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of... transporting in commerce, or importing any dead, dying, disabled or diseased animals or parts of the...

  15. 9 CFR 325.20 - Transportation and other transactions concerning dead, dying, disabled, or diseased livestock...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of livestock that died... other transactions concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of... transporting in commerce, or importing any dead, dying, disabled or diseased animals or parts of the...

  16. Is "healthy dying" a paradox? revisiting an early Kastenbaum challenge.

    PubMed

    Kellehear, Allan

    This article is a review of Robert Kastenbaum's 1979 essay entitled "Healthy dying: A paradoxical quest continues." It begins with a summary of the arguments and challenges in the original essay. This is followed by an evaluation of his original claims in the light of contemporary insights in modern public health history and empirical studies of near-death experiences and death bed visions. The recent development of health promotion in palliative care is described in relation to these developments and Kastenbaum's early question about the paradoxical quest for health while dying is again posed against this background. Given our modern understanding of "health" in current global health policy and debates, it is argued that "healthy dying" is no paradox. Instead, the pursuit of health at the end of life represents a realistic modern desire to compress morbidity, minimize unnecessary suffering, and enhance quality of life at this time.

  17. Phenomenological study of ICU nurses' experiences caring for dying patients.

    PubMed

    King, Phyllis Ann; Thomas, Sandra P

    2013-11-01

    This existential phenomenological study explored caring for the dying based on the philosophical works of Merleau-Ponty. Fourteen critical care nurses were asked to describe lived experiences of caring for dying patients. An encompassing theme of Promises to Keep emerged, with five subthemes, including the following: (a) promise to be truthful: "Nurses are in the game of reality," (b) promise to provide comfort: "I'll make him comfortable," (c) promise to be an advocate: "Just one more day," (d) "Promise that couldn't be kept," and (e) "Promise to remain connected." The essence of intensive care nurses' lived experience of caring for dying patients is captured in the theme Promises to Keep. Nurses accept the reality of death and express strong commitment to making it as comfortable, peaceful, and dignified as possible, despite critical care unit environments that foster a "paradigm of curing" rather than a "paradigm of caring.".

  18. Optimization of an Extrusion Die for Polymer Flow

    NASA Astrophysics Data System (ADS)

    Ridene, Y. Chahbani; Graebling, D.; Boujelbene, M.

    2011-01-01

    In this work, we used the CFD software PolyFlow to optimize the extrusion process of polystyrene flow. In this process, the flow of the molten polymer through the die can be viewed as a critical step for the material in terms of shear rate, self heating by viscous dissipation and temperature reached. The simulation is focused on the flow and heat transfer in the die to obtain a uniform velocity profile and a uniform temperature profile. The rheological behavior of polymer melt was described by the nonlinear Giesekus model. The dependence of the viscosity has also to be taken into account for a correct description of the flow. The design of the die has been validated by our numerical simulation.

  19. Death and dying anxiety among elderly Arab Muslims in Israel.

    PubMed

    Azaiza, Faisal; Ron, Pnina; Shoham, Meyrav; Gigini, Ibrahim

    2010-04-01

    Death and dying anxiety were examined among elderly Arab Muslims in Israel. A total of 145 people aged 60 and over were interviewed using a standardized questionnaire. Nursing home residents reported higher death anxiety than others; women and uneducated participants reported greater levels of fear of death and dying than others. There were no differences based on religiosity. Death anxiety was related to gender and education for elderly living in the community, but social support and self-esteem were additional correlates for those living in nursing homes. The results of this study indicate that fostering a sense that one has a supportive social and familial network is important in decreasing death and dying anxiety among elderly Arab people. It would also be beneficial to provide information and knowledge that might relieve some of the anxiety they experience.

  20. Hospice nurses’ emotional challenges in their encounters with the dying

    PubMed Central

    Ingebretsen, Lina Paola; Sagbakken, Mette

    2016-01-01

    The purpose of this study was to explore nurses’ emotional challenges when caring for the dying in hospices. The study has a qualitative design, and knowledge was developed through a dialectical exchange between theory and data. Ten individual in-depth interviews were conducted with nurses recruited from two hospices in Denmark. Although all of the nurses said that they experienced emotional challenges or felt emotionally touched during their work, the study found a variety of opinions related to the extent to which their emotional reactions should be revealed in their role as a hospice professional. The participants described their emotional challenges as being simultaneously draining and enriching experiences leading to personal and professional growth and development. The study may contribute to increased awareness of emotional challenges for hospice nurses, which involve continuous reflection and balancing between meeting the dying as a human being and meeting the dying as a hospice professional. PMID:27258584

  1. The case for a sociology of dying, death, and bereavement.

    PubMed

    Thompson, Neil; Allan, June; Carverhill, Philip A; Cox, Gerry R; Davies, Betty; Doka, Kenneth; Granek, Leeat; Harris, Darcy; Ho, Andy; Klass, Dennis; Small, Neil; Wittkowski, Joachim

    2016-01-01

    Dying, death, and bereavement do not occur in a social vacuum. How individuals and groups experience these phenomena will be largely influenced by the social context in which they occur. To develop an adequate understanding of dying, death, and bereavement we therefore need to incorporate a sociological perspective into our analysis. This article examines why a sociological perspective is necessary and explores various ways in which sociology can be of practical value in both intellectual and professional contexts. A case study comparing psychological and sociological perspectives is offered by way of illustration.

  2. Do people whose names begin with "D" really die young?

    PubMed

    Smith, Gary

    2012-02-01

    It has been reported that professional baseball players whose first names begin with the letter "D" tend to die relatively young (E. L. Abel & M. L. Kruger, 2010). However, the statistical evidence for this claim is based on selective data and a statistical test that ignores important confounding influences. A valid test applied to more comprehensive data from the same source does not show a statistically significant relationship between initials and longevity. In addition, data for the years 1960 through 2004 for 6.7 million White, non-Hispanic California decedents do not replicate the claim that D's die young.

  3. Neue biosensorische Prinzipien für die Hämoglobin-A1c Bestimmung

    NASA Astrophysics Data System (ADS)

    Stöllner, Daniela

    2002-06-01

    Fructosyl-Valin-Histidin-Leucin-Threonin-Prolin (glkPP) als Kompetitor und Affinitätsligand immobilisiert und so eine regenerierfähige Oberfläche geschaffen. Beim Sandwich-Immunoassay wurde im ersten Schritt Gesamt-Hämoglobin an die mit Haptoglobin (Hp) modifizierte Festphase angereichert und im zweiten Schritt der gebundene HbA1c-Anteil nachgewiesen. Für die Konstruktion des HbA1c-Immunosensors wurden Affinitätsmatrizen durch Modifizierung von Cellulose-Dialysemembranen mit glkPP bzw. Hp hergestellt. Grundlegend studiert wurde die Aktivierung der Cellulose-Membranen mit 1,1'-Carbonyldiimidazol (CDI) und 1-Cyano-4-dimethylaminopyridintetrafluoroborat (CDAP) als Aktivierungsagenzien. Eine gerichtete Immobilisierung der Liganden wurde realisiert, indem glkPP über dessen C-Terminus (einzige Carboxylatgruppe) und Hp über dessen periodat-oxidiertem Kohlenhydratrest an die amino- oder hydrazidfunktionalisierte Membranen kovalent gekoppelt wurden. Mit dem Einsatz der glkPP- und Hp-modifizierten Membranen in der elektrochemischen Messzelle war erstmalig der biosensorische Nachweis von HbA1c möglich. Als Transduktor diente eine Pt-Elektrode, an der das von der GOD generierte H2O2 umgesetzt und ein mit der HbA1c-Konzentration korrelierendes Stromsignal erzeugt wurde. Die Immunosensoren zeigten Ansprechzeiten von 3 s. Mit dem Immunosensor auf Basis des indirekt-kompetitiven Testprinzips wurde eine Kalibrationskurve für HbA1c im Bereich von 0,25-30 µg/ml (3,9-465 nM, CV 3-9 %) mit Assayzeiten von 60 min und mit dem Immunosensor im Sandwich-Format eine Kalibrationskurve im Bereich von 0,5-5 µg/ml (7,8-78 nM; 5-50 % HbA1c vom Gesamt-Hb, CV 6-10 %, 3 h) aufgenommen. Hemoglobin-A1c (HbA1c) is a hemoglobin subtype formed by non-enzymatic reaction of glucose with the N-terminus of the beta-polypeptide chains. As it reflects the glycemic status of diabetics over the preceding 8-12 weeks, the determination of HbA1c has become an established procedure in the management of diabetes

  4. Pultrusion dies -- From massive and power hungry to lean and smart

    SciTech Connect

    Awa, T.W.; Price, H.L.

    1996-11-01

    A lean and smart pultrusion die is proposed. The concept arose from a thermal analysis which showed that present dies involve large heat losses balancing large power inputs with temperature excursions being damped by high die mass. As power costs increase and control costs decrease, pultrusion dies may evolve toward low mass, highly insulated dies with a computer for monitoring and control purposes as well as for heat transfer estimates.

  5. Die Gasultrazentrifuge als mediale Projektion des Kalten Krieges

    NASA Astrophysics Data System (ADS)

    Helmbold, Bernd

    Studien der letzten Dekaden nach der Wiedervereinigung von BRD und DDR erweitern die Perspektive der Wissenschaftsgeschichte vom Fokus des Big Science und der technisch-militärisch-industriellen Auseinandersetzung zwischen den zwei Blöcken zu einer globalen Transformation im Konflikt der Supermächte geprägt durch lokale und auch interne Ausformungen.

  6. Barriers to Quality Care for Dying Patients in Rural Communities

    ERIC Educational Resources Information Center

    Van Vorst, Rebecca F.; Crane, Lori A.; Barton, Phoebe Lindsey; Kutner, Jean S.; Kallail, K. James; Westfall, John M.

    2006-01-01

    Context: Barriers to providing optimal palliative care in rural communities are not well understood. Purpose: To identify health care personnel's perceptions of the care provided to dying patients in rural Kansas and Colorado and to identify barriers to providing optimal care. Methods: An anonymous self-administered survey was sent to health care…

  7. Consumer Aspects of Death and Dying. The Forgotten Dimension.

    ERIC Educational Resources Information Center

    Eddy, James M.; And Others

    1980-01-01

    The consumer aspects of death and dying are discussed as part of a comprehensive death education program. Suggested areas to be covered include traditional funeral procedures and costs; alternatives including cremation, body donation, and funeral and memorial societies; and drawing up a will. Some suggested teaching strategies are outlined. (JMF)

  8. Learning To Say Goodbye: Dealing with Death and Dying.

    ERIC Educational Resources Information Center

    Peck, Rosalie; Stefanics, Charlotte

    This book is intended to help the counselor learn to work with terminal patients. The first part presents historical and cultural attitudes toward death and dying. Fear of death, the role of religion, and common myths about terminal cancer patients are discussed. The second part deals with care and treatment of terminal patients. The significance…

  9. Attitudes of Dental and Medical Students toward Death and Dying.

    ERIC Educational Resources Information Center

    Sundin, Robert H.; And Others

    1979-01-01

    Explores attitudes of dental and medical students toward death and dying. Attitudes toward death influencing choice between dental school and medical school are latent. Attitudes of dental and medical students toward death may be differentially affected by their professional experiences. (Author/BEF)

  10. Technological Change in Michigan's Tool and Die Industry.

    ERIC Educational Resources Information Center

    Smith, Donald N.

    This study was conducted to answer four questions about the tool and die industry in Michigan. These were: (1) What are the current production techniques? (2) To what extent are these industrialists aware of new technologies? (3) What technical and economic factors affect technological change? and (4) To what extent will new technologies replace…

  11. View west of small tooling and forging dies in Blacksmith ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west of small tooling and forging dies in Blacksmith Shop, Boilermakers Department, east side of building 57; during World War II approximately forty women were employed as blacksmith's forging a variety of small tools; these may be the tools they used. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  12. Preventive Therapy with Siblings of a Dying Child.

    ERIC Educational Resources Information Center

    Feinberg, Daniel

    A case study of psychiatric intervention for two sisters whose brother is dying of leukemia is presented. The therapeutic technique attempted to deal with the threatened loss by a forthright approach to the reality situation, encouraging "immunizing" discussions, allowance for catharsis without severe regression, emphasis on reality orientation,…

  13. Media constructions of dying alone: a form of 'bad death'.

    PubMed

    Seale, Clive

    2004-03-01

    In this study, newspaper accounts of people who die alone are analysed, drawing on a sample of 90 articles in the anglophone press that appeared in October 1999. Dying alone is represented as a fearful fate and a moral affair, often being the outcome of an undesirable personal character, either of the deceased or of onlookers, or involving the failings of society at large. It is frequently portrayed as occurring to people who are either geographically or socially distant from 'home', so that an imagined community of readers is encouraged to contemplate a death alone as the consequence of personal or societal breakdown. A degree of stigmatisation, sometimes of those who die alone, sometimes of those perceived to have caused this event, was evident. The negative evaluation of death alone parallels that found in some traditional societies where a death far from home is considered 'bad'. Dying alone contrasts significantly with the sociable, 'good', confessional deaths of newspaper columnists and other media celebrities facing terminal illness.

  14. Death and Dying as a Controversial Issue in Health Education.

    ERIC Educational Resources Information Center

    Russell, Robert D.; And Others

    1982-01-01

    Various perspectives on the inclusion of death education in health education curricula are offered. Discussed are: (1) positive and negative attitudes toward death; (2) teacher competence, qualifications, and skills; (3) religious beliefs about death; (4) Kubler-Ross's Five Stages of Dying; and (5) political implications of teaching about death.…

  15. Dying with Dementia in Long-Term Care

    ERIC Educational Resources Information Center

    Sloane, Philip D.; Zimmerman, Sheryl; Williams, Christianna S.; Hanson, Laura C.

    2008-01-01

    Purpose: To better understand the experiences and potential unmet need of persons who die in long-term care. Design and Methods: We conducted after-death interviews with staff who had cared for 422 decedents with dementia and 159 who were cognitively intact and received terminal care in U.S. nursing homes (NHs) or residential care-assisted living…

  16. Do People Whose Names Begin with "D" Really Die Young?

    ERIC Educational Resources Information Center

    Smith, Gary

    2012-01-01

    It has been reported that professional baseball players whose first names begin with the letter "D" tend to die relatively young (E. L. Abel & M. L. Kruger, 2010). However, the statistical evidence for this claim is based on selective data and a statistical test that ignores important confounding influences. A valid test applied to…

  17. Where a Cancer Patient Dies: The Effect of Rural Residency

    ERIC Educational Resources Information Center

    Burge, Frederick I.; Lawson, Beverley; Johnston, Grace

    2005-01-01

    Context: Surveys indicate 50% to 80% of cancer patients would choose to die at home if possible, although far fewer actually do. In Nova Scotia (NS), cancer deaths occurring out-of-hospital increased from 19.8% in 1992 to 30.2% in 1997. The impact of rural residency on this trend has not been studied. Purpose: To determine the association between…

  18. A Simulation Based on Goldratt's Matchstick/Die Game

    ERIC Educational Resources Information Center

    Martin, Clarence H.

    2007-01-01

    This teaching brief presents a Microsoft® Excel simulation designed to complement and expand upon the well-known matchstick/die game introduced by Goldratt in "The Goal." This simulation performs 100 replications of a 40-period processing run for low, medium, and high levels of process variation and displays the comparative results…

  19. Understandings of Death and Dying for People of Chinese Origin

    ERIC Educational Resources Information Center

    Hsu, Chiung-Yin; O'Connor, Margaret; Lee, Susan

    2009-01-01

    This article introduces the primary beliefs about ancestor worship, Taoism, Confucianism, Buddhism and traditional Chinese medicine that have influenced Chinese people for thousands of years, particularly in relation to death and dying. These cultures and traditions remain important for Chinese people wherever they live. Over a long period,…

  20. Dreams of the Dying Patient: An Exploration of Content.

    ERIC Educational Resources Information Center

    Prince, Pamela N.; Hoffmann, Robert F.

    1991-01-01

    Examined 25 dream reports of individuals in Palliative Care Unit. Content analysis of dream reports supports hypothesis that continuity exists between dreaming and waking experience. Results did not indicate that themes of death and aggression, negative emotion, or infant and child characters were more prevalent among the dying. (Author/NB)

  1. 25 CFR 304.2 - Marking and ownership of dies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Marking and ownership of dies. 304.2 Section 304.2 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER, USE OF... owned by the Indian Arts and Crafts Board....

  2. A Framework for Ethical Decision-Making with Dying Patients.

    ERIC Educational Resources Information Center

    Lafer, Barbara H.; Lee, Sandra S.

    The field of death and dying has become an important area for the development of both research and clinical technique. Psychologists in increasing numbers work in hospital and hospice settings, and therapists treat terminally ill patients and/or their families. Greater attention is being paid to the needs and rights of these patients and families,…

  3. A Membrane Process for Recycling Die Lube from Wastewater Solutions

    SciTech Connect

    Eric S. Peterson; Jessica Trudeau; Bill Cleary; Michael Hackett; William A. Greene

    2003-04-01

    An active-surface membrane technology was used to separate a die lube manufacturing wastewater stream consisting of various oils, hydrocarbons, heavy metals, and silicones. The ultrafiltration membranes reduced organics from initial oil and grease contents by 20–25X, carbon oxygen demand (COD) by 1.5 to 2X, and total organic carbon (TOC) by 0.6, while the biological oxygen demand (BOD) remained constant. The active-surface membranes were not fouled as badly as non-active-surface systems and the active-surface membrane flux levels were consistently higher and more stable than those of the non-active-surface membranes tested. Field testing demonstrated that the rotary microfilter can concentrate the die lube, i.e. remove the glycerin component, and produce a die lube suitable for recycling. The recycling system operated for six weeks with only seven cleaning cycles and no mechanical or electrical failures. Test data and quality records indicate that the die casting scrap was reduced from 8.4 to 7.8%. There is no doubt that this test yielded tremendous results. This separation process presents significant opportunities that can be evaluated further.

  4. A Membrane Process for Recycling Die Lube from Wastewater Solutions

    SciTech Connect

    Peterson, E. S.; Trudeau, J.; Cleary, B.; Hackett, M.; Greene, W. A.

    2003-04-30

    An active-surface membrane technology was used to separate a die lube manufacturing wastewater stream consisting of various oils, hydrocarbons, heavy metals, and silicones. The ultrafiltration membranes reduced organics from initial oil and grease contents by 20-25X, carbon oxygen demand (COD) by 1.5 to 2X, and total organic carbon (TOC) by 0.6, while the biological oxygen demand (BOD) remained constant. The active-surface membranes were not fouled as badly as non-active-surface systems and the active-surface membrane flux levels were consistently higher and more stable than those of the non-active-surface membranes tested. Field testing demonstrated that the rotary microfilter can concentrate the die lube, i.e. remove the glycerin component, and produce a die lube suitable for recycling. The recycling system operated for six weeks with only seven cleaning cycles and no mechanical or electrical failures. Test data and quality records indicate that the die casting scrap was reduced from 8.4 to 7.8%. There is no doubt that this test yielded tremendous results. This separation process presents significant opportunities that can be evaluated further.

  5. Dying and death in some Roma communities: ethical challenges.

    PubMed

    Roman, Gabriel; Gramma, Rodica; Enache, Angela; Pârvu, Andrada; Ioan, Beatrice; Moisa, Ştefana Maria; Dumitraş, Silvia; Chirita, Radu

    2014-04-01

    The Roma people have specific values, therefore their views and beliefs about illness, dying and death are important to be known for health care providers caring for members of this community. The aim of this qualitative study based on 48 semi-structured interviews with Roma patients and caregivers in communities in two regions of Romania was to examine their selfdescribed behaviors and practices, their experiences and perceptions of illness, dying and death. Five more important themes about the Roma people facing dying and death have been identified: (1) The perception of illness in the community as reason for shame and the isolation that results from this, as well as the tendency for Roma people to take this on in their self image; (2) The importance of the family as the major support for the ill/dying individual, including the social requirement that family gather when someone is ill/dying; (3) The belief that the patient should not be told his/her diagnosis for fear it will harm him/her and that the family should be informed of the diagnosis as the main decision maker regarding medical treatment; (4) The reluctance of the Roma to decide on stopping life prolonging treatment; (5) The view of death as 'impure'. These results can be useful for health care providers working with members of the Roma community. By paying attention to and respecting the Roma patients' values, spirituality, and relationship dynamics, the medical staff can provide the most suitable healthcare by respecting the patients' wishes and expectations.

  6. Simple visualization techniques for die casting part and die design. Final report, July 1, 1995--September 30, 1997

    SciTech Connect

    Miller, R.A.; Lu, S.C.; Rebello, A.B.

    1998-05-01

    The objective of this work was to develop and test die casting design evaluation techniques based on the visualization of geometric data that is related to potential defects of problems. Specifically, thickness information is used to provide insight into potential thermal problems in the part and die. Distance from the gate and a special type of animation of the fill pattern is used to provide an assessment of gate, vent and overflow locations. Techniques have been developed to convert part design information in the form of STL files to a volume-based representation called a voxel model. The use of STL files makes the process CAD system independent. Once in voxel form, methods that were developed in this work are used to identify thick regions in the part, thin regions in the part and/or die, distance from user specified entry locations (gates), and the qualitative depiction of the fill pattern. The methods were tested with a prototype implementation on the UNIX platform. The results of comparisons with numerical simulation and field reported defects were surprisingly good. The fill-related methods were also compared against short-shots and a water analog study using high speed video. The report contains the results of the testing plus detailed background material on the construction of voxel models, the methods used for displaying results, and the computational geometric reasoning methods used to create die casting-related information form the voxel model for display to the user.

  7. Simple visualization techniques for die casting part and die design. Final report, July 1, 1995--September 30, 1997

    SciTech Connect

    Miller, R.A.; Lu, S.C.; Rebello, A.B.

    1998-05-01

    The objective of this work was to develop and test die casting design evaluation techniques based on the visualization of geometric data that is related to potential defects of problems. Specifically, thickness information is used to provide insight into potential thermal problems in the part and die. Distance from the gate and a special type of animation of the fill pattern is used to provide an assessment of gate, vent and overflow locations. Techniques have been developed to convert part design information in the form of STL files to a volume-based representation called a voxel model. The use of STL files makes the process CAD system independent. Once in voxel form, methods that were developed in this work are used to identify thick regions in the part, thin regions in the part and/or die, distance from user specified entry locations (gates), and the qualitative depiction of the fill pattern. The methods were tested with a prototype implementation on the UNIX platform. The results of comparisons with numerical simulation and field reported defects were surprisingly good. The fill-related methods were also compared against short-shots and a water analog study using high speed video. The report contains the results of the testing plus detailed background material on the construction of voxel models, the methods used for displaying results, and the computational geometric reasoning methods used to create die casting-related information from the voxel model for display to the user.

  8. Die Tabellen von Ulugh Beg. Die Sternkataloge des Ptolemäus, Ulugh Beg und Tycho Brahe im Vergleich

    NASA Astrophysics Data System (ADS)

    Schwan, Heiner

    2002-09-01

    Im 15. Jahrhundert schuf Ulugh Beg, der Herrscher von Samarkand (1394 - 1449), ein wichtiges Tabellenwerk. Das Kernstück dieses Werks (Zij Ulugh Beg, "Tabellen Ulugh Begs") ist ein Katalog mit 1018 Sternen, ihren Helligkeiten und Positionen. In diesem Bericht werden die Zij Ulugh Beg mit den großen Katalogen von Ptolemäus und Tycho Brahe verglichen.

  9. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    NASA Astrophysics Data System (ADS)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im

  10. Task 7: Die soldering during host site testing. Final report, January1--December 31, 1997

    SciTech Connect

    Goodwin, F.E.; Walkington, W.G.

    1998-01-31

    To provide industrial confirmation of laboratory results produced in Task 6 of this project, five industrial trials were organized with cooperative die casters in the USA. Components cast during these trials ranged from functional electronic heat sinks to decorative household plumbing components. Whereas laboratory work indicated that die temperature and draft angle were the most important process factors influencing solder accumulation, it was not possible to vary draft angle on the established production dies used for these trials. Substantial variations in die temperature were realized however and also die surface conditions were varied, confirming the influence of a secondary variable in the laboratory investigation. Substantial evidence from the trials indicated that die surface temperature is the most important factor for controlling solder build up. The surface roughness of the die casting die greatly influenced the number of castings that could be run before solder initially appeared. Development of careful thermal management techniques, now judged to be beyond the capabilities of most US die casters, will be necessary to control incidences of die soldering found in typical production. Thermal control will involve both control of the bulk die temperature through use of thermally controlled cooling lines, and also regulation of surface temperature by well controlled cooling lines, and also regulation of surface temperature by well controlled die spraying (lubrication) techniques. Further research, development and technology transfer to enhance thermal control capabilities of US die casters is recommended.

  11. Experimental predator removal causes rapid salt marsh die-off.

    PubMed

    Bertness, Mark D; Brisson, Caitlin P; Coverdale, Tyler C; Bevil, Matt C; Crotty, Sinead M; Suglia, Elena R

    2014-07-01

    Salt marsh habitat loss to vegetation die-offs has accelerated throughout the western Atlantic in the last four decades. Recent studies have suggested that eutrophication, pollution and/or disease may contribute to the loss of marsh habitat. In light of recent evidence that predators are important determinants of marsh health in New England, we performed a total predator exclusion experiment. Here, we provide the first experimental evidence that predator depletion can cause salt marsh die-off by releasing the herbivorous crab Sesarma reticulatum from predator control. Excluding predators from a marsh ecosystem for a single growing season resulted in a >100% increase in herbivory and a >150% increase in unvegetated bare space compared to plots with predators. Our results confirm that marshes in this region face multiple, potentially synergistic threats.

  12. How dying cells alert the immune system to danger

    PubMed Central

    Kono, Hajime; Rock, Kenneth L.

    2009-01-01

    When a cell dies in vivo the event does not go unnoticed. The host has evolved mechanisms to detect the death of cells and rapidly investigate the nature of their demise. If cell death is a result of natural causes, that is, it is part of normal physiological processes, then there is little threat to the organism. In this situation, little else is done other than removing the corpse. However, if cells have died as the consequence of some violence or disease, then both defence and repair mechanisms are mobilized. The importance of this process to host defence and disease pathogenesis has only been appreciated relatively recently. This article will review our current knowledge of these processes. PMID:18340345

  13. Defects in the disposal of dying cells lead to autoimmunity.

    PubMed

    Gaipl, Udo S; Franz, Sandra; Voll, Reinhard E; Sheriff, Ahmed; Kalden, Joachim R; Herrmann, Martin

    2004-12-01

    The fast and efficient uptake of dying cells is of main importance to prevent contact of the immune system with intracellular autoantigens. Insufficient clearance of the latter is discussed to drive the humoral autoimmune response in systemic lupus erythematosus. Many adaptor molecules and receptors are involved in the recognition of dying cells. In this paper we focus on the involvement of phosphatidylserine, glycoproteins, and complement and DNaseI in the clearance of apoptotic and necrotic cells, respectively. Furthermore, extracellular danger signals released from necrotic cells are discussed and the uptake process of primary necrotic cells is investigated in detail. Last but not least, the character and origin of clearance defects observed in some systemic lupus erythematosus patients is presented.

  14. Experimental predator removal causes rapid salt marsh die-off

    PubMed Central

    Bertness, Mark D; Brisson, Caitlin P; Coverdale, Tyler C; Bevil, Matt C; Crotty, Sinead M; Suglia, Elena R

    2014-01-01

    Salt marsh habitat loss to vegetation die-offs has accelerated throughout the western Atlantic in the last four decades. Recent studies have suggested that eutrophication, pollution and/or disease may contribute to the loss of marsh habitat. In light of recent evidence that predators are important determinants of marsh health in New England, we performed a total predator exclusion experiment. Here, we provide the first experimental evidence that predator depletion can cause salt marsh die-off by releasing the herbivorous crab Sesarma reticulatum from predator control. Excluding predators from a marsh ecosystem for a single growing season resulted in a >100% increase in herbivory and a >150% increase in unvegetated bare space compared to plots with predators. Our results confirm that marshes in this region face multiple, potentially synergistic threats. PMID:24766277

  15. Relative Lifetime Prediction for CPV Die-Attach Layers: Preprint

    SciTech Connect

    Silverman, T. J.; Bosco, N.; Kurtz, S.

    2012-03-01

    In concentrating photovoltaics (CPV) cell assemblies, a large-area die-attach layer is subjected to thermal cycles, leading to thermomechanical fatigue. This causes cracking and the eventual failure of the CPV cell by thermal runaway. We define a damage metric representing lumped progress toward failure and present a numerical model for computing the accumulation of damage for arbitrary transient temperature conditions. The model is applied to a particular design with a solder die-attach layer. We show that accelerated-test thermal cycles with higher ramp rates cause more damage, both per cycle and per unit time. Outdoor exposure to one entire year in two geographic locations is also simulated, revealing that a year of exposure in Golden, Colorado is equivalent to 1.4 years of exposure in Oak Ridge, Tennessee.

  16. Development and evaluation of die and container materials

    NASA Technical Reports Server (NTRS)

    Wills, R. R.; Niesz, D. E.

    1979-01-01

    X = 0.75 Beta prime Sialon (a silicon aluminum oxynitride) and Sibeon (silicon beryllium oxynitride) are promising die materials. In sessile drop tests in contact with molten silicon, beryllium contamination was less than ppm and aluminum contamination 50 ppm. A shaping die of the Sialon material was successfully fabricated. Dry milling studies for the preparation of Si3N4-Al2O3-ALN mixtures were performed with butanol, acetic anhydride, oleic acid, and triethanolamine milling aids. Optimum mixing was achieved with 0.15 percent triethanolamine using a milling time of 8 hours. Preliminary evaluation of Sibeon materials indicates that they are more resistent to molten silicon attack than Sialon. Silicon contamination from the beryllium was less than aluminum contamination even though the aluminum impurity level in the Sibeon was only 450 to 1300 ppm. Work designed to produce an aluminum-free Sibeon is described.

  17. The Assisted Dying Bill and the role of the physician.

    PubMed

    Mullock, Alexandra

    2015-08-01

    This article explores the role of the physician in the Assisted Dying Bill, which is currently progressing through the House of Lords. The Supreme Court decision in Nicklinson and Others has alerted Parliament to the possibility that the current prohibition against assisted suicide may breach Article 8 of the European Convention in relation to the right to choose how to end one's life. In this article, the role of healthcare professionals in the proposed legalisation of physician-assisted suicide is examined, together with consideration of key ethical concerns over who might be permitted to access assisted dying. Whether the proposed law presents an ethically sound alternative to the current prohibition against assisting in suicide is not clear, but Parliament must now respond in order to address human rights issues and the call to legalise medically assisted suicide.

  18. Modeling of Closed-Die Forging for Estimating Forging Load

    NASA Astrophysics Data System (ADS)

    Sheth, Debashish; Das, Santanu; Chatterjee, Avik; Bhattacharya, Anirban

    2017-02-01

    Closed die forging is one common metal forming process used for making a range of products. Enough load is to exert on the billet for deforming the material. This forging load is dependent on work material property and frictional characteristics of the work material with the punch and die. Several researchers worked on estimation of forging load for specific products under different process variables. Experimental data on deformation resistance and friction were used to calculate the load. In this work, theoretical estimation of forging load is made to compare this value with that obtained through LS-DYNA model facilitating the finite element analysis. Theoretical work uses slab method to assess forging load for an axi-symmetric upsetting job made of lead. Theoretical forging load estimate shows slightly higher value than the experimental one; however, simulation shows quite close matching with experimental forging load, indicating possibility of wide use of this simulation software.

  19. Enhancing impact velocity with shock interactions in a restricting die

    NASA Astrophysics Data System (ADS)

    Anderson, W. W.; Jensen, B. J.; Cherne, F. J.; Owens, C. T.; Ramos, K. J.; Lieber, M. A.

    2014-05-01

    Shock compression and impact studies could benefit from the ability to increase impact velocities that can be achieved with gun systems. Single-stage guns have modest performance (0.2-2 km/s) that limits their utility for high-pressure and high-velocity studies, while more capable systems are expensive and complex. We are developing a technique that uses a low-strength sabot with a tapered die to increase the impact velocity without modifying the gun itself. Impact of the projectile with the die generates a converging shock wave in the sabot that acts to accelerate the front of the projectile, while decelerating the rear portion. Preliminary experiments using this technique have observed a velocity enhancement of up to a factor of two.

  20. [The professor-student relationship in coping with dying].

    PubMed

    Pinho, Líũcia Maria Oliveira; Barbosa, Maria Alves

    2010-03-01

    The new guidelines for undergraduate courses in the field of health care imply a need to prepare professionals to deal with life and death. To study death and dying in the context of nurse education means to contribute to the humanization of education and to preparing humanistic and critical professionals. We performed individual interviews with professors so that each could reveal their thoughts about experiencing death and dying in the educational relationship between nurse/professor and the nursing student in the hospital environment. Content analysis was performed using ideas close to those of Heidegger, revealing that education towards the concept and experience of death appears to be possible only if there is reflection regarding human existence, thoughts, and accepting finitude. By understanding one's own attitudes towards death and existence, it is possible to perceive possibilities in education for care in the death process.

  1. She's going to die: the case of Angela C.

    PubMed

    Annas, G J

    1988-01-01

    Annas criticizes the legal reasoning in a District of Columbia Superior Court case, In re A.C. (1987). A dying woman who was 26 weeks pregnant agreed to attempts to prolong her life to give her fetus a better chance to be born healthy. When death seemed imminent, she appeared to refuse a cesarean section, and a Superior Court judge was called to the hospital on the advice of its legal counsel. After hearing from lawyers for the hospital, the patient, and the fetus, the judge ordered the surgery, and an appeals court concurred. The infant died two hours after delivery, the mother two days later. Annas argues that the decision rested on several false assumptions about the legal rights and obligations of pregnant women. In his view, the judges "justified their brutal and unprincipled opinion on the basis that [A.C.] was almost dead," and therefore the fetus's interests outweighed hers.

  2. Thermal Simulation of Four Die-Attach Materials

    DTIC Science & Technology

    2008-01-01

    contact between circuit board layers. ..............................................................5 Figure 4. Simulation results with AuSn braze on...being investigated, three were metallic, with good thermal conductivity. These materials were a Au/Sn braze , in an 80%/20% mixture; a CPES nanoscale...silver powder; and Kester R520A solder paste, an alloy which is 96.5% Sn, 3.0% Ag, and 0.5% Cu , commonly called SAC. The fourth die-attach material

  3. Should the patient be allowed to die? 1

    PubMed Central

    Nicholson, Richard

    1975-01-01

    In considering the patient's right to a certain quality of dying, this essay outlines how the legal and ethical justifications for passive euthanasia depend on the doctrine of acts and omissions. It is suggested that this doctrine is untenable and that alternative justifications are needed. The development of the modern mechanistic approach to death is traced, showing that a possible basis for an humane way of death lies in a reacceptance of a metaphysical concept of life. PMID:1100831

  4. Years after Inventors Die, Royalties Are Pennies from Heaven

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    2009-01-01

    Sarah L. Kieweg had her own nice surprise when the University of Central Florida contacted her. She understood quite a bit about her father's pioneering work on artificial intelligence in the 1990s. Still, in 2006, eight years after he died of a heart attack, at age 50, the call from the university came out of the blue: some of James R. Driscoll's…

  5. Spray forming process for producing molds, dies and related tooling

    DOEpatents

    McHugh, Kevin M.; Key, James F.

    1998-01-01

    A method for spray forming manufacturing of near-net-shape molds, dies and related toolings, wherein liquid material such as molten metal, metallic alloys, or polymers are atomized into fine droplets by a high temperature, high velocity gas and deposited onto a pattern. Quenching of the atomized droplets provides a heat sink, thereby allowing undercooled and partially solidified droplets to be formed in-flight. Composites can be formed by combining the atomized droplets with solid particles such as whiskers or fibers.

  6. Deburring die-castings by wet vibratory plant

    NASA Technical Reports Server (NTRS)

    Loeschbart, H. M.

    1980-01-01

    A wet vibratory procedure for the removal of burrs from die castings is described. In this process synthetic abrasive chips and detergent solutions are agitated with the work in such a way as to produce a spiral circulatory movement. Details of various forms of vibrator basin and shapes of abrasive are illustrated. The automation of deburring is illustrated through the application of vibrators of spiral design in combination with transport and drying devices.

  7. Voices of discontent? Conscience, compromise, and assisted dying.

    PubMed

    Huxtable, Richard; Mullock, Alexandra

    2015-01-01

    If some form of assisted dying is to be legalised, we are likely to hear voices of discontent, not least from the medical profession and some of its members, who might be expected to provide the service. The profession generally favours a position of opposition, premised on an ethic of 'caring not killing', which might be said to convey its 'professional conscience'. There will, of course, also be individual conscientious objectors. In this article, we initially explore the nature and sources of conscience and we argue that conscience does merit respect. We also recognise that professionals, qua professionals, are bound to serve their patients, some of whom will want (and may be entitled to) that which their doctors do not wish to provide. Reflecting on the different values in issue, we suggest that there is a case for principled compromise which would afford professionals a limited right to conscientiously object, while also protecting patients. We then relate these reflections to assisted dying specifically. In the absence of any definitive steer from the purported integrity of medicine, we suspect that the profession could adopt a neutral stance on this divisive issue. We nevertheless anticipate individual objections if the law does move to embrace assisted dying, and we argue that such objections should be respected, according to the terms of the compromise model we defend.

  8. Results from prototype die-to-database reticle inspection system

    NASA Astrophysics Data System (ADS)

    Mu, Bo; Dayal, Aditya; Broadbent, Bill; Lim, Phillip; Goonesekera, Arosha; Chen, Chunlin; Yeung, Kevin; Pinto, Becky

    2009-03-01

    A prototype die-to-database high-resolution reticle defect inspection system has been developed for 32nm and below logic reticles, and 4X Half Pitch (HP) production and 3X HP development memory reticles. These nodes will use predominantly 193nm immersion lithography (with some layers double patterned), although EUV may also be used. Many different reticle types may be used for these generations including: binary (COG, EAPSM), simple tritone, complex tritone, high transmission, dark field alternating (APSM), mask enhancer, CPL, and EUV. Finally, aggressive model based OPC is typically used, which includes many small structures such as jogs, serifs, and SRAF (sub-resolution assist features), accompanied by very small gaps between adjacent structures. The architecture and performance of the prototype inspection system is described. This system is designed to inspect the aforementioned reticle types in die-todatabase mode. Die-to-database inspection results are shown on standard programmed defect test reticles, as well as advanced 32nm logic, and 4X HP and 3X HP memory reticles from industry sources. Direct comparisons with currentgeneration inspection systems show measurable sensitivity improvement and a reduction in false detections.

  9. High pressure die casting of Fe-based metallic glass

    PubMed Central

    Ramasamy, Parthiban; Szabo, Attila; Borzel, Stefan; Eckert, Jürgen; Stoica, Mihai; Bárdos, András

    2016-01-01

    Soft ferromagnetic Fe-based bulk metallic glass key-shaped specimens with a maximum and minimum width of 25.4 and 5 mm, respectively, were successfully produced using a high pressure die casting (HPDC) method, The influence of die material, alloy temperature and flow rate on the microstructure, thermal stability and soft ferromagnetic properties has been studied. The results suggest that a steel die in which the molten metal flows at low rate and high temperature can be used to produce completely glassy samples. This can be attributed to the laminar filling of the mold and to a lower heat transfer coefficient, which avoids the skin effect in the steel mold. In addition, magnetic measurements reveal that the amorphous structure of the material is maintained throughout the key-shaped samples. Although it is difficult to control the flow and cooling rate of the molten metal in the corners of the key due to different cross sections, this can be overcome by proper tool geometry. The present results confirm that HPDC is a suitable method for the casting of Fe-based bulk glassy alloys even with complex geometries for a broad range of applications. PMID:27725780

  10. High pressure die casting of Fe-based metallic glass

    NASA Astrophysics Data System (ADS)

    Ramasamy, Parthiban; Szabo, Attila; Borzel, Stefan; Eckert, Jürgen; Stoica, Mihai; Bárdos, András

    2016-10-01

    Soft ferromagnetic Fe-based bulk metallic glass key-shaped specimens with a maximum and minimum width of 25.4 and 5 mm, respectively, were successfully produced using a high pressure die casting (HPDC) method, The influence of die material, alloy temperature and flow rate on the microstructure, thermal stability and soft ferromagnetic properties has been studied. The results suggest that a steel die in which the molten metal flows at low rate and high temperature can be used to produce completely glassy samples. This can be attributed to the laminar filling of the mold and to a lower heat transfer coefficient, which avoids the skin effect in the steel mold. In addition, magnetic measurements reveal that the amorphous structure of the material is maintained throughout the key-shaped samples. Although it is difficult to control the flow and cooling rate of the molten metal in the corners of the key due to different cross sections, this can be overcome by proper tool geometry. The present results confirm that HPDC is a suitable method for the casting of Fe-based bulk glassy alloys even with complex geometries for a broad range of applications.

  11. Der Physik-Nobelpreis vor 100 Jahren Die Entdeckung des trägen Gases

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2004-11-01

    Im Jahr 1904 erhielt der britische Physiker Lord Rayleigh (John William Strutt, 1842 bis 1919) den Nobelpreis für seine Untersuchungen über die Dichte von Gasen und die Entdeckung des Edelgases Argon.

  12. A comparison of the accuracy of two removable die systems with intact working casts.

    PubMed

    Aramouni, P; Millstein, P

    1993-01-01

    This study evaluated the reproducibility of die position using two removable die systems and two die stones. Poly(vinyl siloxane) impressions were made of a stainless steel, U-shaped arch with four evenly spaced abutments. Six groups were evaluated: Zeiser system/Fuji Rock; Zeiser system/Die Keen; solid cast/Fuji Rock; solid cast/Die Keen; Fuji Rock/Pindex; and Die Keen/Pindex. An optical comparator was used to measure the height of each abutment, the distance between the anterior abutments, and the distance between the posterior abutments. The Zeiser system with either Fuji Rock or Die Keen yielded the greatest accuracy. Die Keen exhibited more linear expansion than Fuji Rock, and solid casts had less distortion than the Pindex system.

  13. Most U.S. Kids Who Die from Flu Are Unvaccinated

    MedlinePlus

    ... medlineplus.gov/news/fullstory_164426.html Most U.S. Kids Who Die From Flu Are Unvaccinated Researchers estimate ... Researchers found that about three-quarters of U.S. kids who died of flu complications between 2010 and ...

  14. Milling strategies evaluation when simulating the forming dies' functional surfaces production

    NASA Astrophysics Data System (ADS)

    Ižol, Peter; Tomáš, Miroslav; Beňo, Jozef

    2016-05-01

    The paper deals with selection and evaluation of milling strategies, available in CAM systems and applicable when complicated shape parts are produced, such as forming dies. A method to obtain samples is proposed and this stems from real forming die surface machined by proper strategies. The strategy applicability for the whole part - forming die - is reviewed by the particular specimen evaluation. The presented methodology has been verified by machining model die and comparing it to the production procedure proposed in other CAM systems.

  15. Impact of Simulation Technology on Die and Stamping Business

    NASA Astrophysics Data System (ADS)

    Stevens, Mark W.

    2005-08-01

    Over the last ten years, we have seen an explosion in the use of simulation-based techniques to improve the engineering, construction, and operation of GM production tools. The impact has been as profound as the overall switch to CAD/CAM from the old manual design and construction methods. The changeover to N/C machining from duplicating milling machines brought advances in accuracy and speed to our construction activity. It also brought significant reductions in fitting sculptured surfaces. Changing over to CAD design brought similar advances in accuracy, and today's use of solid modeling has enhanced that accuracy gain while finally leading to the reduction in lead time and cost through the development of parametric techniques. Elimination of paper drawings for die design, along with the process of blueprinting and distribution, provided the savings required to install high capacity computer servers, high-speed data transmission lines and integrated networks. These historic changes in the application of CAE technology in manufacturing engineering paved the way for the implementation of simulation to all aspects of our business. The benefits are being realized now, and the future holds even greater promise as the simulation techniques mature and expand. Every new line of dies is verified prior to casting for interference free operation. Sheet metal forming simulation validates the material flow, eliminating the high costs of physical experimentation dependent on trial and error methods of the past. Integrated forming simulation and die structural analysis and optimization has led to a reduction in die size and weight on the order of 30% or more. The latest techniques in factory simulation enable analysis of automated press lines, including all stamping operations with corresponding automation. This leads to manufacturing lines capable of running at higher levels of throughput, with actual results providing the capability of two or more additional strokes per

  16. Chandra Observations of Dying Radio Sources in Galaxy Clusters

    NASA Technical Reports Server (NTRS)

    Murgia, M.; Markevitch, M.; Govoni, F.; Parma, P.; Fanti, R.; de Ruiter, H. R.; Mack, K.-H.

    2012-01-01

    Context. The dying radio sources represent a very interesting and largely unexplored stage of the active galactic nucleus (AGN) evolution. They are considered to be very rare, and almost all of the few known ones were found in galaxy clusters. However, considering the small number detected so far, it has not been possible to draw any firm conclusions about their X-ray environment. Aims. We present X-ray observations performed with the Chandra satellite of the three galaxy clusters Abell 2276, ZwCl 1829.3+6912, and RX J1852.1+5711, which harbor at their center a dying radio source with an ultra-steep spectrum that we recently discovered. Methods. We analyzed the physical properties of the X-ray emitting gas surrounding these elusive radio sources. We determined the global X-ray properties of the clusters, derived the azimuthally averaged profiles of metal abundance, gas temperature, density, and pressure. Furthermore, we estimated the total mass profiles. Results. The large-scale X-ray emission is regular and spherical, suggesting a relaxed state for these systems. Indeed, we found that the three clusters are also characterized by significant enhancements in the metal abundance and declining temperature profiles toward the central region. For all these reasons, we classified RX J1852.1+5711, Abell 2276, and ZwCl 1829.3+6912 as cool-core galaxy clusters. Conclusions. We calculated the non-thermal pressure of the radio lobes assuming that the radio sources are in the minimum energy condition. For all dying sources we found that this is on average about one to two orders of magnitude lower than that of the external gas, as found for many other radio sources at the center of galaxy groups and clusters. We found marginal evidence for the presence of X-ray surface brightness depressions coincident with the fossil radio lobes of the dying sources in A2276 and ZwCl 1829.3+691. We estimated the outburst age and energy output for these two dying sources. The energy power from

  17. Chandra observations of dying radio sources in galaxy clusters

    NASA Astrophysics Data System (ADS)

    Murgia, M.; Markevitch, M.; Govoni, F.; Parma, P.; Fanti, R.; de Ruiter, H. R.; Mack, K.-H.

    2012-12-01

    Context. The dying radio sources represent a very interesting and largely unexplored stage of the active galactic nucleus (AGN) evolution. They are considered to be very rare, and almost all of the few known ones were found in galaxy clusters. However, considering the small number detected so far, it has not been possible to draw any firm conclusions about their X-ray environment. Aims: We present X-ray observations performed with the Chandra satellite of the three galaxy clusters Abell 2276, ZwCl 1829.3+6912, and RX J1852.1+5711, which harbor at their center a dying radio source with an ultra-steep spectrum that we recently discovered. Methods: We analyzed the physical properties of the X-ray emitting gas surrounding these elusive radio sources. We determined the global X-ray properties of the clusters, derived the azimuthally averaged profiles of metal abundance, gas temperature, density, and pressure. Furthermore, we estimated the total mass profiles. Results: The large-scale X-ray emission is regular and spherical, suggesting a relaxed state for these systems. Indeed, we found that the three clusters are also characterized by significant enhancements in the metal abundance and declining temperature profiles toward the central region. For all these reasons, we classified RX J1852.1+5711, Abell 2276, and ZwCl 1829.3+6912 as cool-core galaxy clusters. Conclusions: We calculated the non-thermal pressure of the radio lobes assuming that the radio sources are in the minimum energy condition. For all dying sources we found that this is on average about one to two orders of magnitude lower than that of the external gas, as found for many other radio sources at the center of galaxy groups and clusters. We found marginal evidence for the presence of X-ray surface brightness depressions coincident with the fossil radio lobes of the dying sources in A2276 and ZwCl 1829.3+691. We estimated the outburst age and energy output for these two dying sources. The energy power from

  18. Application of Magnetic Kinds of Nondestructive Inspection to Parts From Die Tool Steels

    NASA Astrophysics Data System (ADS)

    Kornilova, A. V.; Selishchev, A. I.; Idarmachev, I. M.

    2016-01-01

    Possibilities of control of the level of accumulated damage in dies for cold and hot forming as a function of the coercivity are considered. The coercivity of the material of dies for hot forging and cold stamping is studied. Formulas are obtained for determining the coercivity in steels for hot die forging in the state as delivered.

  19. 9 CFR 309.3 - Dead, dying, disabled, or diseased and similar livestock.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Dead, dying, disabled, or diseased and... AND VOLUNTARY INSPECTION AND CERTIFICATION ANTE-MORTEM INSPECTION § 309.3 Dead, dying, disabled, or diseased and similar livestock. (a) Livestock found to be dead or in a dying condition on the premises...

  20. Palliative and Curative Care Nurses' Attitudes Toward Dying and Death in the Hospital Setting.

    ERIC Educational Resources Information Center

    Thompson, Edward H.

    1986-01-01

    Examined sociodemographic background, nursing unit, amount of experience caring for dying patients, death anxiety, and attitudes toward working with dying patients among 56 nurses in palliative, surgical, and pediatric services. Work setting was found to be a more significant force in shaping attitudes toward caring for the dying than was…

  1. Strippable grid facilitates removal of grid-surfaced conical workpiece from die

    NASA Technical Reports Server (NTRS)

    Ruppe, E. P.

    1966-01-01

    Female die facilitates the removal of a sheet metal structure from a die used for explosive forming of the metal. The female die consists of a smooth conical frustum made of fiber glass with a cured epoxy-resin surface on which a molded grid pattern made of a polyurethane resin is overlaid.

  2. Verbesserte Ausbildung für neue Betriebsleiter und -ingenieure - eine wichtige Investition in die Zukunft

    NASA Astrophysics Data System (ADS)

    Franta, Oliver

    Bedingt durch die Globalisierung und die damit einhergehende Verschärfung des Wettbewerbs befinden sich die Produktionsbetriebe der chemischen Industrie in stetigem Wandel. Für Betriebsleiter und Betriebsingenieure werden damit Fähigkeiten wie Kostenmanagement, Sozial- und Organisationskompetenz, Führungsqualifikationen und unternehmerisches Handeln immer wichtiger. Neben den Anforderungsprofilen bei Neueinstellungen ist dies auch bei der Fortbildung zu berücksichtigen. Das Trainingsprogramm der Evonik Degussa wurde daher durch die Konzeption neuer Seminare und die Anpassung bestehender Weiterbildungsmaßnahmen weiterentwickelt. Neben Vorträgen und Fallbeispielen sind ebenfalls die Durchführung von Planspielen sowie das Kennenlernen eines Produktionsbetriebes einer anderen Organisationseinheit enthalten. Ziel ist es vor allem die unternehmerische Orientierung neuer Betriebsleiter und -ingenieure zu fördern, die Innovationsgeschwindigkeit zu erhöhen und durch Kenntnis und Nutzung bereits anderweitig entwickelter Lösungen und Methoden die Produktivität zu steigern. Die Produktionsmeister werden aufgrund der Bedeutung dieser Funktion für die Führung der Mitarbeiter und bei der Umsetzung von Veränderungsprojekten in das Ausbildungsprogramm einbezogen. Der Erfolg des Trainingsprogramms zeigt sich an den Teilnehmerzahlen und den ausgesprochen positiven Rückmeldungen.

  3. Die Liberalisierung de Telekommunikationsbranche in Deutschland( The Liberalization of the Telecommunication-Industry in Germany)

    DTIC Science & Technology

    2004-03-01

    anderen europdischen Ldndern - eine dramatische Entwick- lung erlebt: Zahlreiche neue Anbieter von Telekommunikationsdienstleistungen haben den Markt ...AG (DTAG), zweitens die Liberalisierung des Marktzutritts bzw. Offfiung des Marktes , und drittens die Deregulierung. Wdhrend also mit Liberalisierung...die Offnung des Marktes ffir neue Anbieter gemeint ist, wird unter Deregulierung der Abbau staatlicher Vorschriften iiber das Verhalten der Markt

  4. Method of making cascaded die mountings with springs-loaded contact-bond options

    DOEpatents

    Hsu, John S.; Adams, Donald J.; Su, Gui-Jia; Marlino, Laura D.; Ayers, Curtis W.; Coomer, Chester

    2007-06-19

    A cascaded die mounting device and method using spring contacts for die attachment, with or without metallic bonds between the contacts and the dies, is disclosed. One embodiment is for the direct refrigerant cooling of an inverter/converter carrying higher power levels than most of the low power circuits previously taught, and does not require using a heat sink.

  5. Cascaded die mountings with spring-loaded contact-bond options

    DOEpatents

    Hsu, John S.; Adams, Donald J.; Su, Gui-Jia; Marlino, Laura D.; Ayers, Curtis W.; Coomer, Chester

    2005-08-16

    A cascaded die mounting device and method using spring contacts for die attachment, with or without metallic bonds between the contacts and the dies, is disclosed. One embodiment is for the direct refrigerant cooling of an inverter/converter carrying higher power levels than most of the low power circuits previously taught, and does not require using a heat sink.

  6. Wer entdeckte die Allgemeine Relativitätstheorie? Prioritätsstreit zwischen Hilbert und Einstein

    NASA Astrophysics Data System (ADS)

    Sommer, Klaus P.

    2005-09-01

    Im November 1915 arbeiteten Albert Einstein und David Hilbert an den Feldgleichungen der Gravitationstheorie. Im Jahre 1997 behaupteten die Wissenschaftshistoriker Corry, Renn und Stachel in einer viel beachteten Arbeit, Hilbert habe die entscheidenden Formeln von Einstein gestohlen. Grundlage ihrer Argumentation war eine wieder gefundene Korrekturfahne von Hilberts entscheidender Arbeit. Die Physikhistorikerin Daniela Wuensch bringt jedoch detaillierte Argumente dafür vor, dass die entscheidende Quelle, nämlich die Korrekturfahne, in neuerer Zeit manipuliert worden ist, um Einsteins Priorität unangetastet zu lassen. Einstein bleibt aber der Entdecker der Allgemeinen Relativitätstheorie.

  7. Application of direct laser melting to restore damaged steel dies

    NASA Astrophysics Data System (ADS)

    Jang, Jeong Hwan; Joo, Byeong Don; Mun, Sung Min; Sung, Min Young; Moon, Young Hoon

    2011-02-01

    Direct laser melting (DLM) technology can be applied to restore damaged steel dies. To understand the effects of DLM process parameters such as the laser power and scan rate, a series of experiments was conducted to determine the optimal operating parameters. To investigate the laser melting characteristics, the depth/height ratio, depth/width ratio and micro-hardness as a function of the laser energy density were analyzed. Fe-Cr and Fe-Ni layers were deposited on a steel die with 11.38 J/mm2 of energy input. The wear-resistance and the friction coefficient of the deposited layer were investigated by a pin-on-disk test. The penetration depth decreased as the scan rate increased as a consequence of the shorter interaction time. The depth/height ratio of the deposited layer decreased with an increase in the scan rate. The depth/width ratio increased as laser power increased and the scan rate decreased. The deposition shape of the Fe-Ni powder was relatively shallow and wide compared with that of the Fe-Cr powder. The scan rate had a substantial effect upon the deposition height, with the Fe-Cr powder melting more than the Fe-Ni powder. The micro-hardness of the layer melted from the powders is higher than that of the substrate, and the hardness of the laser-surface-melted layer without any metal powder is higher compared to that of the metal-powder-melted layer. The direct laser melting process with Fe-Ni powder represents a superior method when restoring a steel die when the bead shape and hardness of the restored surface are important outcome considerations.

  8. [The rescue of the human in the patient who dies].

    PubMed

    García Sánchez, Emilio

    2012-01-01

    In this article I discuss briefly a proposal for the recovery of the essential content of the concept of human nature through the careful attention to ethics which must be received by a terminal ill person in the last phase of life. I propose palliative medicine as a way to rescue the human mind in the life of dying patients to whom the fullness of nature and human dignity belongs. It's about recovering the original medical ethos through the exercise of the virtues through which staff can be trained to recognize the weak, the sick, miserable, the dispossessed are important, are worthy of medicine, used for science: are human and quite valid.

  9. Dying slowly with compassion and dignity: A commentary

    PubMed Central

    Rakos, Richard F.

    1998-01-01

    Fraley offers a provocative behavior-analytic perspective on the process of slow death. I argue that the value of his insightful analysis is severely compromised by his insistence on equating behavioral competence with personal worth. Fraley errs by proclaiming that his philosophy is science, that existing social practices are essential human attributes, and that idiosyncratic reinforcing stimuli are universally functional. Further, his philosophical tenet is fundamentally inconsistent with his genuinely humane goal of understanding and promoting protracted dying as a behavioral rather than metaphysical phenomenon. PMID:22478294

  10. Developing a Blended Course on Dying, Loss, and Grief

    PubMed Central

    Kavanaugh, Karen; Andreoni, V. Ann; Wilkie, Diana J.; Burgener, Sandra; Buschmann, MaryBeth Tank; Henderson, Gloria; Hsiung, Yi-Fang Yvonne; Zhao, Zhongsheng

    2010-01-01

    An important component of end-of-life education is to provide health professionals with content related to dying, loss, and grief. The authors describe the strategies used to develop and offer a blended course (integration of classroom face-to-face learning with online learning) that addressed the sensitive and often emotional content associated with grieving and bereavement. Using Kolb’s experiential learning theory, a set of 4 online learning modules, with engaging, interactive elements, was created. Course evaluations demonstrated the success of the blended course in comparison to the traditional, exclusive face-to-face approach. PMID:19412055

  11. Reliability Testing the Die-Attach of CPV Cell Assemblies

    SciTech Connect

    Bosco, N.; Sweet, C.; Kurtz, S.

    2011-02-01

    Results and progress are reported for a course of work to establish an efficient reliability test for the die-attach of CPV cell assemblies. Test vehicle design consists of a ~1 cm2 multijunction cell attached to a substrate via several processes. A thermal cycling sequence is developed in a test-to-failure protocol. Methods of detecting a failed or failing joint are prerequisite for this work; therefore both in-situ and non-destructive methods, including infrared imaging techniques, are being explored as a method to quickly detect non-ideal or failing bonds.

  12. Spray forming process for producing molds, dies and related tooling

    DOEpatents

    McHugh, K.M.; Key, J.F.

    1998-02-17

    A method is disclosed for spray forming manufacturing of near-net-shape molds, dies and related toolings, wherein liquid material such as molten metal, metallic alloys, or polymers are atomized into fine droplets by a high temperature, high velocity gas and deposited onto a pattern. Quenching of the atomized droplets provides a heat sink, thereby allowing undercooled and partially solidified droplets to be formed in-flight. Composites can be formed by combining the atomized droplets with solid particles such as whiskers or fibers. 17 figs.

  13. Spray forming system for producing molds, dies and related tooling

    DOEpatents

    McHugh, Kevin M.

    2000-01-01

    A system for the spray forming manufacturing of near-net-shape molds, dies and related toolings, wherein liquid material such as molten metal, metallic alloys, or polymers are atomized into fine droplets by a high temperature, high velocity gas and deposited onto a pattern. Quenching of the atomized droplets provides a heat sink, thereby allowing undercooled and partially solidified droplets to be formed in-flight. Composites can be formed by combining the atomized droplets with solid particles such as powders, whiskers or fibers.

  14. [Recent case law about the right to die].

    PubMed

    Bascuñán R, Antonio

    2016-04-01

    This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a judicial consensus about the right to die. This consensus recognized the legal right of patients to reject medical treatments but did not recognize the right to be assisted by a physician to commit suicide. This exclusion is changing in the recent case law of Canada and the United Kingdom, which accepts the fundamental right of terminal patients to medically assisted suicide.

  15. Three-Dimensional Computed Tomography as a Method for Finding Die Attach Voids in Diodes

    NASA Technical Reports Server (NTRS)

    Brahm, E. N.; Rolin, T. D.

    2010-01-01

    NASA analyzes electrical, electronic, and electromechanical (EEE) parts used in space vehicles to understand failure modes of these components. The diode is an EEE part critical to NASA missions that can fail due to excessive voiding in the die attach. Metallography, one established method for studying the die attach, is a time-intensive, destructive, and equivocal process whereby mechanical grinding of the diodes is performed to reveal voiding in the die attach. Problems such as die attach pull-out tend to complicate results and can lead to erroneous conclusions. The objective of this study is to determine if three-dimensional computed tomography (3DCT), a nondestructive technique, is a viable alternative to metallography for detecting die attach voiding. The die attach voiding in two- dimensional planes created from 3DCT scans was compared to several physical cross sections of the same diode to determine if the 3DCT scan accurately recreates die attach volumetric variability

  16. Die Starter: A New System to Manage Early Feasibility in Sheet Metal Forming

    NASA Astrophysics Data System (ADS)

    Narainen, Rodrigue; Porzner, Harald

    2016-08-01

    Die Starter, a new system developed by ESI Group, allows the user to drastically reduce the number of iterations during the early tool process feasibility. This innovative system automatically designs the first quick die face, generating binder and addendum surfaces (NURBS surfaces) by taking account the full die process. Die Starter also improves the initial die face based on feasibility criteria (avoiding splits, wrinkles) by automatically generating the geometrical modifications of the binder and addendum and the bead restraining forces with minimal material usage. This paper presents a description of the new system and the methodology of Die Starter. Some industrial examples are presented from the part geometry to final die face including automatic developed flanges, part on binder and inner binder.

  17. Dying autologous cells as instructors of the immune system.

    PubMed

    Munoz, L E; Herrmann, M; Berens, C

    2015-01-01

    In an organism, cell death occurs at many different sites and in many different forms. It is frequently part of normal development or serves to maintain cell homeostasis. In other cases, cell death not only occurs due to injury, disease or infection, but also as a consequence of various therapeutic interventions. However, in all of these scenarios, the immune system has to react to the dying and dead cells and decide whether to mount an immune response, to remain quiet or to initiate healing and repopulation. This is essential for the organism, testified by many diseases that are associated with malfunctioning in the cell death process, the corpse removal, or the ensuing immune responsiveness. Therefore, dying cells generally have to be considered as instructors of the immune system. How this happens and which signals and pathways contribute to modulate or shape the immune response is still elusive in many conditions. The articles presented in this Special Issue address such open questions. They highlight that the context in which cell death occurs will not only influence the cell death process itself, but also affect the surrounding cellular milieu, how the generation and presence of 'eat me' signals can have an impact on cell clearance, and that the exact nature of the residual 'debris' and how it is processed are fundamental to determining the immunological consequences. Hopefully, these articles initiate new approaches and new experiments to complete our understanding of how cell death and the immune system interact with each other.

  18. Die Parting welt marks' measurement using structured laser analysis

    NASA Astrophysics Data System (ADS)

    Sarr, Dennis P.; Mullen, Joey H.

    1997-01-01

    Heating and cooling air for an aircraft interior is transported using metal ducts. These ducts vary in size from a few centimeters to twelve centimeters in diameter. In the assembly of aircraft air ducts, coupling is swaged onto the ducts. In assuring the mechanical dies are operating properly the die parting welt mark is inspected. The current method of visual inspection and checking with calipers does not allow implementation of statistical process control methods. In an effort to improve this process check, a new measurement method is being developed. A feasibility study indicated that a structured light laser system would be a good approach. A few requirements are: it must be portable to be used at different locations within the fabrication area, it must be fast, it should be easy to use by the mechanic, the reading must be accurate, a hard copy print out is required, and it must be non-destructive. Due to the mechanical configuration of the duct and coupling, a camera with magnification optics is used. The measurement of the bump has a maximum height of 50.8 microns. The prototype systems uses computer vision and custom software written in the C language. This paper discusses different measurement methods tested and the benefits of each technology. The development of a specialized system is justified for production use. This paper describes the prototype system and some of its configuration for factory testing.

  19. Interventions to enhance the spiritual aspects of dying.

    PubMed

    Chochinov, Harvey Max; Cann, Beverley J

    2005-01-01

    In recent years, medical and allied health publications have begun to address various topics on spirituality. Scholars have posited numerous definitions of spirituality and wrestled with the notion of spiritual pain and suffering. Researchers have examined the relationship between spirituality and health and explored, among other topics, patients' perceptions of their spiritual needs, particularly at the end of life. This paper summarizes salient evidence pertaining to spirituality, dying patients, their health care providers, and family or informal caregivers. We examine the challenging issue of how to define spirituality, and provide a brief overview of the state of evidence addressing interventions that may enhance or bolster spiritual aspects of dying. There are many pressing questions that need to be addressed within the context of spiritual issues and end-of-life care. Efforts to understand more fully the constructs of spiritual well-being, transcendence, hope, meaning, and dignity, and to correlate them with variables and outcomes such as quality of life, pain control, coping with loss, and acceptance are warranted. Researchers should also frame these issues from both faith-based and secular perspectives, differing professional viewpoints, and in diverse cultural settings. In addition, longitudinal studies will enable patients' changing experiences and needs to be assessed over time. Research addressing spiritual dimensions of personhood offers an opportunity to expand the horizons of contemporary palliative care, thereby decreasing suffering and enhancing the quality of time remaining to those who are nearing death.

  20. Study on stretching effect of multiple die forming technology

    NASA Astrophysics Data System (ADS)

    Park, Ji-woo; Kim, Jeong; Kang, Beom-soo

    2013-12-01

    The multiple die forming (MDF) technology is suitable for flexible manufacturing, and it affords several advantages including its applicability to various forming processes such as single-curved surface forming, and double-curved surface forming. In sheet metal forming process, the elastic recovery has become a problem. Therefore, the stretch forming process is applied MDF technology to reduce elastic recovery effect. Numerical simulation is carried out for a saddle-type surface forming using ABAQUS. Every simulation case performs spring-back analysis to find elastic recovery effect after forming simulation. In this simulation, urethane pads are defined based on a hyperelastic material model as a cushion for the smoothness of forming surface. The elastic recovery deformation behavior is also investigated to consider the exact result after the last forming process, and then, the actual experiments are performed to confirm the formability of this forming process. By comparing the simulation and the experimental results, the tendency of the decreased amount of elastic recovery from the application of stretch process is verified. Consequently, it is confirmed that the multiple die stretch forming process has the capability and feasibility of being used to manufacture the curved surfaces of sheet metal.

  1. How an organism dies affects the fitness of its neighbors.

    PubMed

    Durand, Pierre M; Rashidi, Armin; Michod, Richard E

    2011-02-01

    Programmed cell death (PCD), a genetically regulated cell suicide program, is ubiquitous in the living world. In contrast to multicellular organisms, in which cells cooperate for the good of the organism, in unicells the cell is the organism and PCD presents a fundamental evolutionary problem. Why should an organism actively kill itself as opposed to dying in a nonprogrammed way? Proposed arguments vary from PCD in unicells being maladaptive to the assumption that it is an extreme form of altruism. To test whether PCD could be beneficial to nearby cells, we induced programmed and nonprogrammed death in the unicellular green alga Chlamydomonas reinhardtii. Cellular contents liberated during non-PCD are detrimental to others, while the contents released during PCD are beneficial. The number of cells in growing cultures was used to measure fitness. Thermostability studies revealed that the beneficial effect of the PCD supernatant most likely involves simple heat-stable biomolecules. Non-PCD supernatant contains heat-sensitive molecules like cellular proteases and chlorophyll. These data indicate that the mode of death affects the origin and maintenance of PCD. The way in which an organism dies can have beneficial or deleterious effects on the fitness of its neighbors.

  2. Extensive intraalveolar pulmonary hemorrhage in infants dying after surfactant therapy.

    PubMed

    Pappin, A; Shenker, N; Hack, M; Redline, R W

    1994-04-01

    To assess the possible relationship between exogenous surfactant therapy and pulmonary hemorrhage in premature infants, we compared autopsy findings in 15 infants treated with exogenous surfactant and in 29 who died before the introduction of surfactant therapy. Infants who met the following criteria were included: birth weight 501 to 1500 gm, survival 4 hours to 7 days, and no congenital anomalies. Average birth weight, gestational age, and age at death were equivalent for the two groups. High rates of pulmonary hemorrhage were present in both groups (treated 80% vs untreated 83%). The untreated group had higher incidences of interstitial hemorrhage and lung hematomas and significantly more large interstitial hemorrhages: 31% untreated versus 0% treated (p < 0.05). The overall rate of intraalveolar hemorrhage was similar in the two groups, but surfactant-treated infants were more likely to have extensive intraalveolar hemorrhage: 53% versus 14% (p < 0.05). Most surfactant-treated infants who survived more than 24 hours had extensive intraalveolar hemorrhage (8/9). Patients who had extensive intraalveolar hemorrhage, with or without prior surfactant therapy, frequently had clinically significant pulmonary hemorrhage (7/12). These findings indicate that infants who die after surfactant therapy have higher rates of a specific type of pulmonary hemorrhage--extensive intraalveolar hemorrhage.

  3. Effect of Some Parameters on the Cast Component Properties in Hot Chamber Die Casting

    NASA Astrophysics Data System (ADS)

    Singh, Rupinder; Singh, Harvir

    2016-04-01

    Hot chamber die casting process is designed to achieve high dimensional accuracy for small products by forcing molten metal under high pressure into reusable moulds, called dies. The present research work is aimed at study of some parameters (as a case study of spring adjuster) on cast component properties in hot chamber die casting process. Three controllable factors of the hot chamber die casting process (namely: pressure at second phase, metal pouring temperature and die opening time) were studied at three levels each by Taguchi's parametric approach and single-response optimization was conducted to identify the main factors controlling surface hardness, dimensional accuracy and weight of the casting. Castings were produced using aluminium alloy, at recommended parameters through hot chamber die casting process. Analysis shows that in hot chamber die casting process the percentage contribution of second phase pressure, die opening time, metal pouring temperature for surface hardness is 82.48, 9.24 and 6.78 % respectively. While in the case of weight of cast component the contribution of second phase pressure is 94.03 %, followed by metal pouring temperature and die opening time (4.58 and 0.35 % respectively). Further for dimensional accuracy contribution of die opening time is 76.97 %, metal pouring temperature is 20.05 % and second phase pressure is 1.56 %. Confirmation experiments were conducted at an optimal condition showed that the surface hardness, dimensional accuracy and weight of the castings were improved significantly.

  4. Optimizations Of Coat-Hanger Die, Using Constraint Optimization Algorithm And Taguchi Method

    NASA Astrophysics Data System (ADS)

    Lebaal, Nadhir; Schmidt, Fabrice; Puissant, Stephan

    2007-05-01

    Polymer extrusion is one of the most important manufacturing methods used today. A flat die, is commonly used to extrude thin thermoplastics sheets. If the channel geometry in a flat die is not designed properly, the velocity at the die exit may be perturbed, which can affect the thickness across the width of the die. The ultimate goal of this work is to optimize the die channel geometry in a way that a uniform velocity distribution is obtained at the die exit. While optimizing the exit velocity distribution, we have coupled three-dimensional extrusion simulation software Rem3D®, with an automatic constraint optimization algorithm to control the maximum allowable pressure drop in the die; according to this constraint we can control the pressure in the die (decrease the pressure while minimizing the velocity dispersion across the die exit). For this purpose, we investigate the effect of the design variables in the objective and constraint function by using Taguchi method. In the second study we use the global response surface method with Kriging interpolation to optimize flat die geometry. Two optimization results are presented according to the imposed constraint on the pressure. The optimum is obtained with a very fast convergence (2 iterations). To respect the constraint while ensuring a homogeneous distribution of velocity, the results with a less severe constraint offers the best minimum.

  5. Role of crab herbivory in die-off of New England salt marshes.

    PubMed

    Holdredge, Christine; Bertness, Mark D; Altieri, Andrew H

    2009-06-01

    Die-offs of cordgrass are pervasive throughout western Atlantic salt marshes, yet understanding of the mechanisms precipitating these events is limited. We tested whether herbivory by the native crab, Sesarma reticulatum, is generating die-offs of cordgrass that are currently occurring on Cape Cod, Massachusetts (U.S.A.), by manipulating crab access to cordgrass transplanted into die-off areas and healthy vegetation. We surveyed 12 Cape Cod marshes to investigate whether the extent of cordgrass die-off on creek banks, where die-offs are concentrated, was related to local Sesarma grazing intensity and crab density. We then used archived aerial images to examine whether creek bank die-off areas have expanded over the past 2 decades and tested the hypothesis that release from predation, leading to elevated Sesarma densities, is triggering cordgrass die-offs by tethering crabs where die-offs are pervasive and where die-offs have not yet been reported. Intensity of crab grazing on transplanted cordgrass was an order of magnitude higher in die-off areas than in adjacent vegetation. Surveys revealed that Sesarma herbivory has denuded nearly half the creek banks in Cape Cod marshes, and differences in crab-grazing intensity among marshes explained >80% of variation in the extent of the die-offs. Moreover, the rate of die-off expansion and area of marsh affected have more than doubled since 2000. Crab-tethering experiments suggest that release from predation has triggered elevated crab densities that are driving these die-offs, indicating that disruption of predator-prey interactions may be generating the collapse of marsh ecosystems previously thought to be exclusively under bottom-up control.

  6. Laser tabbed die: A repairable, high-speed die-interconnection technology. 1994 LDRD final report 93-SR-089

    SciTech Connect

    Malba, V.; Bernhardt, A.F.

    1995-09-01

    A unique technology for multichip module production is presented. The technology, called Laser Tabbed Die (L-TAB), consists of a method for forming surface-mount-type {open_quotes}gull wing{close_quotes} interconnects on bare dice. The dice are temporarily bonded to a sacrificial substrate which has a polymer thin film coated onto it. The gull wings are formed on the side of the die with a direct-write laser patterning process which allows vertical as well as horizontal image formation. Using the laser patterning system, trenches are formed in a positive electrodeposited photoresist (EDPR) which is plated onto a metal seed layer, allowing copper to be electroplated through the resultant mask. After stripping the resist and the metal seed layer, the polymer film on the substrate is dissolved, releasing the chip with the {open_quotes}gull wings{close_quotes} intact. The chips are then bonded onto a circuit board or permanent substrate with solder or conductive adhesive.

  7. Effect of vegetation die-off on tidal marshland tested

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2012-04-01

    Consisting of densely vegetated platforms raised slightly above sea level, and interwoven by channels of water meandering inland from the coast, tidal marshlands help buffer against strong storm surges, protect against flooding, limit coastal erosion, and provide a valuable habitat for a vast array of coastal species. Continued global climate change, however, has researchers worried about the stability of coastal marshlands in light of rising temperatures and sea levels and a declining ocean pH. Of particular concern over shorter time scales are the potential consequences for marsh dynamics should there be a mass die-off of marshland vegetation. Investigations of the effects of mass vegetative death on marshland behavior have been conducted almost exclusively using computer simulations, but Temmerman et al. sought to bolster this previous research with empirical evidence.

  8. Interpreting guidance on prosecution for assisted dying for district nurses.

    PubMed

    Griffith, Richard

    2014-11-01

    Following a ruling by the House of Lords in 2009, the Director of Public Prosecutions issued guidance setting out the circumstances that would be likely to lead to the prosecution of a person for encouraging or assisting suicide under the Suicide Act 1961, section 2. In that guidance, a district nurse assisting a person to commit suicide would be one of the circumstances that would lead to prosecution. The Director of Public Prosecutions recently unexpectedly amended her guidance in relation to health professionals. This article discusses the implications of the amendment and argues that it will cause confusion among district nurses and give rise to an unrealistic expectation about the role a district nurse can lawfully take in assisting a person to die.

  9. [Death and dying process: evidences from the literature of nursing].

    PubMed

    Júnior, Fernando José Guedes da Silva; Santos, Lissandra Chaves de Sousa; Moura, Pedro Victor dos Santos; Melo, Belisa Maria Silva; Monteiro, Claudete Ferreira de Souza

    2011-01-01

    The objective was to identify the profile of production and analyze perceptions, feelings and confrontations on the process of death and dying in the practice evidenced in nursing scientific production in the period 1994 to 2009. There was a qualitative, descriptive research, developed through a systematic literature review with metasynthesis from the meta-ethnographic method. Ten studies met the inclusion criteria, this set was subjected to quality assessment checklist with Critical Appraisal Skills Programme. Subjects perceive this process as a transition, separation and finitude. This is permeated with feelings of frustration and powerlessness and the most effective interventions to this issue is the development of coping strategies that vary with the reality of each individual.

  10. A support group for fathers whose partners died from cancer.

    PubMed

    Yopp, Justin Michael; Rosenstein, Donald Lee

    2013-04-01

    Men who are raising dependent children after their spouses or partners have died from cancer face unique challenges adjusting to single parenthood while managing their grief and the grief of their children. Unfortunately, the needs of those widowers have been overlooked in the clinical literature and no published interventions are designed specifically for that population. The current article details the creation and implementation of a peer support group for fathers recently widowed because of their wives' deaths from cancer. Initial observations and emergent themes from the group are described. Group members suggested that they benefited from participation in the support group and that this form of psychosocial support is a promising intervention for fathers in similar circumstances.

  11. A right to die? Euthanasia and the law in Australia.

    PubMed

    Bartels, Lorana; Otlowski, Margaret

    2010-02-01

    This article examines the legal regulation of active voluntary euthanasia and assisted suicide in Australia. The Dying with Dignity Bill 2009 (Tas), which was recently defeated by the Tasmanian Parliament, is discussed, as well as other jurisdictions' past and present legislative developments in this context. The recent case law is also considered to ascertain how "mercy killing" or assisted suicide cases are dealt with by the criminal justice system, with particular reference to the case of R v Justins [2008] NSWSC 1194. This is followed by a critical evaluation of the key arguments for and against euthanasia. The article concludes by examining the significance of the Tasmanian Bill and the implications of such legislation.

  12. [Psychological and psychoanalytical issues in Schreker's opera "Die Gezeichneten"].

    PubMed

    Gasenzer, Elena Romana

    2016-11-01

    Franz Schrekers opera "Die Gezeichneten" is the artistically answer to Sigmund Freud's psychoanalysis. The proceedings in this drama discuss some principles of psychoanalyses. The figures show typical psychological mechanisms like repression, sublimation or regression and also the typical symptoms of neurosis. During the date of origin of the opera, Freud's method of psychoanalysis becomes well known and a lot of physicians and psychologists begin with their education in it. Themes like the theory of sexuality by Freud were discussed in the Vienna society. The story contains all mechanisms of psychoanalysis and discloses the psychopathology of the society of "fín de siègle" on the end of the 19th century. Franz Schreker's opera is like a forecasting of the nemesis, which in Europe occurs two decades later. The figures of the opera show the central facts of psychoanalysis and their artificial expression in music and performance.

  13. Forest die-back modified plankton recovery from acidic stress.

    PubMed

    Vrba, Jaroslav; Kopáček, Jiří; Fott, Jan; Nedbalová, Linda

    2014-03-01

    We examined long-term data on water chemistry of Lake Rachelsee (Germany) following the changes in acidic depositions in central Europe since 1980s. Despite gradual chemical recovery of Rachelsee, its biological recovery was delayed. In 1999, lake recovery was abruptly reversed by a coincident forest die-back, which resulted in elevated terrestrial export of nitrate and ionic aluminum lasting ~5 years. This re-acidification episode provided unique opportunity to study plankton recovery in the rapidly recovering lake water after the abrupt decline in nitrate leaching from the catchment. There were sudden changes both in lake water chemistry and in plankton biomass structure, such as decreased bacterial filaments, increased phytoplankton biomass, and rotifer abundance. The shift from dominance of heterotrophic to autotrophic organisms suggested their substantial release from severe phosphorus stress. Such a rapid change in plankton structure in a lake recovering from acidity has, to the best of our knowledge, not been previously documented.

  14. Vacuum Die Casting of Silicon Sheet for Photovoltaic Applications

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The development of a vacuum die-casting process for producing silicon sheet suitable for photovoltaic cells with a terrestrial efficiency greater than 12 percent and having the potential to be scaled for large quantity production is considered. The initial approach includes: (1) obtaining mechanical design parameters by using boron nitride, which has been shown to non-wetting to silicon; (2) optimizing silicon nitride material composition and coatings by sessile drop experiments; (3) testing effectiveness of fluoride salt interfacial media with a graphite mold; and (4) testing the effect of surface finish using both boron nitride and graphite. When the material and mechanical boundary conditions are established, a finalized version of the prototype assembly will be constructed and the casting variables determined.

  15. Why do people with rheumatoid arthritis still die prematurely?

    PubMed

    Gabriel, S E

    2008-12-01

    Premature death has been long recognised as a manifestation of rheumatoid arthritis (RA). Three lines of evidence can explain why patients with RA die prematurely and why the mortality gap between patients with RA and the general population appears to widening. First, patients with RA have a higher risk of several serious comorbid conditions and they tend to experience worse outcomes after the occurrence of these illnesses. Second, patients with RA do not appear to receive optimal primary or secondary preventive care. And third, the systemic inflammation and immune dysfunction associated with RA appears to promote and accelerate comorbidity and mortality. This paper provides a brief summary and interpretation of the data underlying these findings. Together, these results provide a compelling argument in favour of a focused research programme aimed specifically at eliminating premature death in patients with RA.

  16. Luminescence dating of Middle Stone Age deposits at Die Kelders.

    PubMed

    Feathers, J K; Bush, D A

    2000-01-01

    Luminescence dating of sediments has not been used extensively for dating Middle Stone Age deposits in South Africa, despite its potential for contributing to a poorly dated record. Such deposits at Die Kelders cave, on the southern South African coast, consist of narrow bands of occupation debris separated by thicker layers of aeolian sands containing much less evidence of occupation. Homogeneous, aeolian sediments are usually considered ideal for luminescence dating. Here we report luminescence analyses of five samples from these sands that demonstrate sufficient bleaching prior to burial to validate dating and that yield ages of about 60-70 ka, in agreement with other evidence from sedimentology, archaeology and electron spin resonance. Lack of significant differences in the ages suggests the deposits accumulated fairly rapidly during the early part of the Last Glaciation.

  17. The Great Diadema antillarum Die-Off: 30 Years Later

    NASA Astrophysics Data System (ADS)

    Lessios, H. A.

    2016-01-01

    In 1983-1984, the sea urchin Diadema antillarum suffered mass mortality throughout the Caribbean, Florida, and Bermuda. The demise of this herbivore contributed to a phase shift of Caribbean reefs from coral-dominated to alga-dominated communities. A compilation of published data of D. antillarum population densities shows that there has been moderate recovery since 1983, with the highest rates on islands of the eastern Caribbean. On the average the current population densities are approximately 12% of those before the die-off, apparently because of recruitment limitation, but the exact factors that are constraining the recovery are unclear. Scattered D. antillarum cohorts in some localities and aggregation of settled individuals in shallow water have created zones of higher herbivory in which juvenile coral recruitment, survivorship, and growth are higher than they are in alga-dominated areas. Unlike other stressors on Caribbean coral reefs, recent changes in D. antillarum populations progress toward aiding the recovery of coral cover.

  18. Über die Kleinsignalgewinnmessung nach Ladenburg-Levy

    NASA Astrophysics Data System (ADS)

    Grunwald, R.; Hertz, J. H.

    Es werden die Möglichkeiten und Probleme der Anwendung einer alten Methode von Ladenburg-Levy zur Kleinsignalgewinnmessung in Niederdruck-Impulsgasentladungen diskutiert. Als Beispiel werden Ergebnisse der zeitaufgelösten Gewinnmessung am 2. Pos. System des Stickstoff ( = 337 nm) mitgeteilt.Translated AbstractOn the Small-Signal Gain Measurement According to Ladenburg-LevyThe application of an old method of Ladenburg-Levy to small-signal gain measurement in pulsed low pressure gas discharges as well as the problems connected with this method are discussed. As an example experimental results of time resolved gain measurements in the 2nd positive system of nitrogen ( = 337 nm) are presented.

  19. Development of Thin Section Zinc Die Casting Technology

    SciTech Connect

    Goodwin, Frank

    2013-10-31

    A new high fluidity zinc high pressure die casting alloy, termed the HF alloy, was developed during laboratory trials and proven in industrial production. The HF alloy permits castings to be achieved with section thicknesses of 0.3 mm or less. Technology transfer activities were conducted to develop usage of the HF high fluidity alloy. These included production of a brochure and a one-hour webinar on the HF alloy. The brochure was then sent to 1,184 product designers in the Interzinc database. There was excellent reception to this mailing, and from this initial contact 5 technology transfer seminars were conducted for 81 participants from 30 companies across a wide range of business sectors. Many of the successful applications to date involve high quality surface finishes. Design and manufacturing assistance was given for development of selected applications.

  20. Modeling and numerical simulation of multiflux die in the multilayer co-extrusion process

    NASA Astrophysics Data System (ADS)

    Mun, Jun Ho; Kim, Ju Hyeon; Mun, Sang Ho; Kim, See Jo

    2017-02-01

    It is of great importance to understand the stretching and folding mechanism in the multiflux co-extrusion die to get uniform multilayer distribution at the end of die lip in the multilayer co-extrusion processes. In this work, to understand the mechanism of the layer distribution, modeling and numerical simulation were carried out for three-dimensional flow analysis in the multilayer co-extrusion die. The multilayer flow fields were numerically visualized and analyzed on the arbitrary cross-section of the multiflux die. In addition, numerical results for the multiflux die characteristics were obtained for non-Newtonian fluids in terms of power-law index for the cross model, which will be useful for the optimal design of screw and die, simultaneously, in the multilayer co-extrusion process.

  1. Validation of the Quality of Dying (QOD)-Hospice Scale

    PubMed Central

    Cagle, John G.; Munn, Jean C.; Hong, Seokho; Clifford, Maggie; Zimmerman, Sheryl

    2014-01-01

    Context Measuring the quality of the dying experience is important for hospice providers. However, few instruments exist that assess the quality of one’s dying; and those that do, have not been well validated in hospice. Objectives This study tested the properties of the Quality of Death-Hospice Scale (QOD-Hospice) to provide preliminary validation data on internal consistency, inter-rater reliability, convergent validity and factorability in a hospice setting. Additionally, results of the factor analysis were used to create a brief version of the measure. Methods Bereaved informal caregivers who had provided care for a hospice patient were recruited from a large non-profit hospice. Participants completed post-death surveys, which included the QOD-Hospice and other study measures. Convergent validity was tested by exploring hypothesized associations with related instruments measuring: negative emotional states (Depression Anxiety Stress Scale-21); emotional grief (Texas Revised Inventory of Grief-2); social support (Lubben Social Network Scale-6); and a single item measure of satisfaction with hospice care. Results Seventy caregivers participated in the survey (40 primary caregivers, 30 secondary caregivers), most of whom were female (67%) and white (81%). The QOD-Hospice produced an alpha of 0.86, an intraclass correlation of 0.49 between caregivers of the same decedent, and was correlated with all measures testing convergent validity (P<0.05; in the hypothesized direction) and most, but not all, subscales. An exploratory factor analysis elicited two factors, Preparation (seven items) and Security (six items), which were combined to create a 13-item version of the scale, the QOD-Hospice-SF. Conclusion Although further testing of the QOD-Hospice measures is needed, preliminary evidence suggests the instruments are reliable and valid for use in hospice. PMID:25057986

  2. Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation.

    PubMed

    Oliveira, Patrícia; Carvalho, Joana; Rocha, Sara; Azevedo, Mafalda; Reis, Inês; Camilo, Vânia; Sousa, Bárbara; Valente, Sofia; Paredes, Joana; Almeida, Raquel; Huntsman, David; Oliveira, Carla

    2016-10-10

    Dies1/VISTA induces embryonic stem-cell differentiation, via BMP-pathway, but also acts as inflammation regulator and immune-response modulator. Dies1 inhibition in a melanoma-mouse model led to increased tumour-infiltrating T-cells and decreased tumour growth, emphasizing Dies1 relevance in tumour-microenvironment. Dies1 is involved in cell de/differentiation, inflammation and cancer processes, which mimic those associated with Epithelial-to-Mesenchymal-Transition (EMT). Despite this axis linking Dies1 with EMT and cancer, its expression, modulation and relevance in these contexts is unknown. To address this, we analysed Dies1 expression, its regulation by promoter-methylation and miR-125a-5p overexpression, and its association with BMP-pathway downstream-effectors, in a TGFβ1-induced EMT-model, cancer cell-lines and primary samples. We detected promoter-methylation as a mechanism controlling Dies1 expression in our EMT-model and in several cancer cell-lines. We showed that the relationship between Dies1 expression and BMP-pathway effectors observed in the EMT-model, was not present in all cell-lines, suggesting that Dies1 has other cell-specific effectors, beyond the BMP-pathway. We further demonstrated that: Dies1 expression loss is a recurrent event in GC, caused by promoter methylation and/or miR-125a-5p overexpression and; GC-microenvironment myofibroblasts overexpress Dies1. Our findings highlight Dies1 as a novel player in GC, with distinct roles within tumour cells and in the tumour-microenvironment.

  3. Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation

    PubMed Central

    Oliveira, Patrícia; Carvalho, Joana; Rocha, Sara; Azevedo, Mafalda; Reis, Inês; Camilo, Vânia; Sousa, Bárbara; Valente, Sofia; Paredes, Joana; Almeida, Raquel; Huntsman, David; Oliveira, Carla

    2016-01-01

    Dies1/VISTA induces embryonic stem-cell differentiation, via BMP-pathway, but also acts as inflammation regulator and immune-response modulator. Dies1 inhibition in a melanoma-mouse model led to increased tumour-infiltrating T-cells and decreased tumour growth, emphasizing Dies1 relevance in tumour-microenvironment. Dies1 is involved in cell de/differentiation, inflammation and cancer processes, which mimic those associated with Epithelial-to-Mesenchymal-Transition (EMT). Despite this axis linking Dies1 with EMT and cancer, its expression, modulation and relevance in these contexts is unknown. To address this, we analysed Dies1 expression, its regulation by promoter-methylation and miR-125a-5p overexpression, and its association with BMP-pathway downstream-effectors, in a TGFβ1-induced EMT-model, cancer cell-lines and primary samples. We detected promoter-methylation as a mechanism controlling Dies1 expression in our EMT-model and in several cancer cell-lines. We showed that the relationship between Dies1 expression and BMP-pathway effectors observed in the EMT-model, was not present in all cell-lines, suggesting that Dies1 has other cell-specific effectors, beyond the BMP-pathway. We further demonstrated that: Dies1 expression loss is a recurrent event in GC, caused by promoter methylation and/or miR-125a-5p overexpression and; GC-microenvironment myofibroblasts overexpress Dies1. Our findings highlight Dies1 as a novel player in GC, with distinct roles within tumour cells and in the tumour-microenvironment. PMID:27721458

  4. The Effects of Externally Solidified Product on Wave Celerity and Quality of Die Cast Products

    SciTech Connect

    Carroll Mobley; Yogeshwar Sahai; Jerry Brevick

    2003-10-10

    The cold chamber die casting process is used to produce essentially all the die cast aluminum products and about 50% of the die cast magnesium products made today. Modeling of the cold chamber die casting process and metallographic observations of cold chamber die cast products indicate that typically 5 to 20% of the shot weight is solidified in the shot sleeve before or during cavity filling. The protion of the resulting die casting which is solidified in the shot sleeve is referred to as externally solidified product, or, when identified as a casting defect, as cold flakes. This project was directed to extending the understanding of the effects of externally solidified product on the cold chamber die casting process and products to enable the production of defect-free die castings and reduce the energy associated with these products. The projected energy savings from controlling the fraction of externally solidified product in die cast components is 40 x 10 Btu through the year 2025.

  5. Hospice Care for Children With Cancer: Where Do These Children Die?

    PubMed

    Thienprayoon, Rachel; Lee, Simon C; Leonard, David; Winick, Naomi

    2015-07-01

    Hospice is an important provider of end of life care; many children who die of cancer enroll in hospice programs. How frequently such children remain in hospice to die at home, or disenroll from hospice and die in the hospital, has not been described. A child's location of death has important implications for quality of life and parental adaptation. This represents a subanalysis of a retrospective study of 202 consecutive oncology patients who died at a single center between January 1, 2006 and December 31, 2010. Of 95 children who enrolled in hospice, 82 had known location of death. Sixty (73%) died at home or an inpatient hospice unit, 15 (18%) died in the oncology unit, 5 (6%) died in the intensive care unit, and 2 (2%) died in the emergency department. The median length of hospice services was 41 days, twice the national median of 21 days reported in adults. One quarter of children disenrolled from hospice care, ultimately dying in an acute care setting. Further studies are warranted to explore the hospice experience in children, and to address modifiable factors that may impact a family's choice to withdraw from hospice care.

  6. Thermal fatigue behavior of H-13 die steel for aluminum die casting with various ion sputtered coatings

    NASA Technical Reports Server (NTRS)

    Nieh, C. Y.; Wallace, J. F.

    1981-01-01

    Sputtered coatings of Mo, W, Pt, Ag, Au, Co, Cr, Ni, Ag + Cu, Mo + Pt, Si3N4, A1N, Cr3C2, Ta5Si3, and ZrO2 were applied to a 2-inch-square, 7-inch-long thermal fatigue test specimen which was then internally water cooled and alternately immersed in molten aluminum and cooled in air. After 15,000 cycles the thermal fatigue cracks at the specimen corners were measured. Results indicate that a significant improvement in thermal fatigue resistance was obtained with platinum, molybdenum, and tungsten coatings. Metallographic examination indicates that the improvement in thermal fatigue resistance resulted from protection of the surface of the die steel from oxidation. The high yield strength and ductility of molybdenum and tungsten contributed to the better thermal fatigue resistance.

  7. Live to die another way: modes of programmed cell death and the signals emanating from dying cells.

    PubMed

    Fuchs, Yaron; Steller, Hermann

    2015-06-01

    All life ends in death, but perhaps one of life's grander ironies is that it also depends on death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for animal development, tissue homeostasis and pathogenesis. Originally, PCD was almost synonymous with apoptosis; recently, however, alternative mechanisms of PCD have been reported. Here, we provide an overview of several distinct PCD mechanisms, namely apoptosis, autophagy and necroptosis. In addition, we discuss the complex signals that emanate from dying cells, which can either trigger regeneration or instruct additional killing. Further advances in understanding the physiological roles of the various mechanisms of cell death and their associated signals will be important to selectively manipulate PCD for therapeutic purposes.

  8. Live to die another way: modes of programmed cell death and the signals emanating from dying cells

    PubMed Central

    Fuchs, Yaron; Steller, Hermann

    2015-01-01

    Preface All life ends in death, but perhaps one of life’s grander ironies is that it also depends on death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for animal development, tissue homeostasis and pathogenesis. Originally, PCD was virtually synonymous with apoptosis, but recently, alternative PCD mechanisms have been reported. Here, we provide an overview of several distinct PCD mechanisms, namely apoptosis, autophagy and necroptosis. In addition, we discuss the complex signals emanating from dying cells, which can either fuel regeneration or instruct additional killing. Further advances in understanding the physiological role of multiple cell death mechanisms and associated signals will be important to selectively manipulate PCD for therapeutic purposes. PMID:25991373

  9. Dying star creates sculpture of gas and dust

    NASA Astrophysics Data System (ADS)

    2004-09-01

    Sculpture of gas and dust hi-res Size hi-res: 125 Kb Credits: ESA, NASA, HEIC and The Hubble Heritage Team (STScI/AURA) Dying star creates sculpture of gas and dust The so-called Cat's Eye Nebula, formally catalogued NGC 6543 and seen here in this detailed view from the NASA/ESA Hubble Space Telescope, is one of the most complex planetary nebulae ever seen in space. A planetary nebula forms when Sun-like stars gently eject their outer gaseous layers to form bright nebulae with amazing twisted shapes. Hubble first revealed NGC 6543's surprisingly intricate structures including concentric gas shells, jets of high-speed gas and unusual shock-induced knots of gas in 1994. This new image, taken with Hubble's Advanced Camera for Surveys (ACS), reveals the full beauty of a bull's-eye pattern of eleven or more concentric rings, or shells, around the Cat’s Eye. Each ‘ring’ is actually the edge of a spherical bubble seen projected onto the sky - which is why it appears bright along its outer edge. High resolution version (JPG format) 125 Kb High resolution version (TIFF format) 2569 Kb Acknowledgment: R. Corradi (Isaac Newton Group of Telescopes, Spain) and Z. Tsvetanov (NASA). Sculpture of gas and dust hi-res Size hi-res: 287 Kb Credits: Nordic Optical Telescope and Romano Corradi (Isaac Newton Group of Telescopes, Spain) Dying star creates sculpture of gas and dust An enormous but extremely faint halo of gaseous material surrounds the Cat’s Eye Nebula and is over three light-years across. Some planetary nebulae been found to have halos like this one, likely formed of material ejected during earlier active episodes in the star's evolution - most likely some 50 000 to 90 000 years ago. This image was taken by Romano Corradi with the Nordic Optical Telescope on La Palma in the Canary Islands. The image is constructed from two narrow-band exposures showing oxygen atoms (1800 seconds, in blue) and nitrogen atoms (1800 seconds, in red). High resolution version (JPG

  10. Improved Life of Die Casting Dies of H13 Steel by Attaining Improved Mechanical Properties and Distortion Control During Heat Treatment

    SciTech Connect

    J. F. Wallace; D. Schwam

    1998-10-01

    The ultimate goal of this project is to increase die casting die life by using fast enough quenching rates to obtain good toughness and fatigue resistance in premium grade H-13 steel dies. The main tasks of the project were to compile a database on physical and mechanical properties of H-13; conduct gas quenching experiments to determine cooling rates of dies in difference vacuum furnaces; measure the as-quenched distortion of dies and the residual stresses; generate finite element analysis models to predict cooling rates, distortion, and residual stress of gas quenched dies; and establish rules and create PC-based expert system for prediction of cooling rates, distortion, and residual stress in vacuum/gas quenched H-13 dies. Cooling curves during gas quenching of H-13 blocks and die shapes have been measured under a variety of gas pressure. Dimensional changes caused by the gas quenching processes have been determined by accurate mapping of all surfaces with coordinate measuring machines before and after the quench. Residual stresses were determined by the ASTM E837 hole-drilling strain gage method. To facilitate the computer modeling work, a comprehensive database of H-13 mechanical and physical properties has been compiled. Finite element analysis of the heat treated shapes has been conducted using the TRAST/ABAQUS codes. There is a good fit between the predicted and measured distortion contours. However, the magnitude of the predicted distortion and residual stresses does not match well the measured values. Further fine tuning of the model is required before it can be used to predict distortion and residual stress in a quantitative manner. This last step is a prerequisite to generating rules for a reliable expert system.

  11. HUBBLE PROBES THE COMPLEX HISTORY OF A DYING STAR

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This NASA Hubble Space Telescope image shows one of the most complex planetary nebulae ever seen, NGC 6543, nicknamed the 'Cat's Eye Nebula.' Hubble reveals surprisingly intricate structures including concentric gas shells, jets of high-speed gas and unusual shock-induced knots of gas. Estimated to be 1,000 years old, the nebula is a visual 'fossil record' of the dynamics and late evolution of a dying star. A preliminary interpretation suggests that the star might be a double-star system. The dynamical effects of two stars orbiting one another most easily explains the intricate structures, which are much more complicated than features seen in most planetary nebulae. (The two stars are too close together to be individually resolved by Hubble, and instead, appear as a single point of light at the center of the nebula.) According to this model, a fast 'stellar wind' of gas blown off the central star created the elongated shell of dense, glowing gas. This structure is embedded inside two larger lobes of gas blown off the star at an earlier phase. These lobes are 'pinched' by a ring of denser gas, presumably ejected along the orbital plane of the binary companion. The suspected companion star also might be responsible for a pair of high-speed jets of gas that lie at right angles to this equatorial ring. If the companion were pulling in material from a neighboring star, jets escaping along the companion's rotation axis could be produced. These jets would explain several puzzling features along the periphery of the gas lobes. Like a stream of water hitting a sand pile, the jets compress gas ahead of them, creating the 'curlicue' features and bright arcs near the outer edge of the lobes. The twin jets are now pointing in different directions than these features. This suggests the jets are wobbling, or precessing, and turning on and off episodically. The image was taken with the Wide Field Planetary Camera-2 on September 18, 1994. NGC 6543 is 3,000 light-years away in the

  12. 26 CFR 20.2201-1 - Members of the Armed Forces dying during an induction period.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Members of the Armed Forces dying during an... Miscellaneous § 20.2201-1 Members of the Armed Forces dying during an induction period. (a) The additional...) (see paragraph (b) of this section) and while in active service as a member of the Armed Forces of...

  13. 26 CFR 20.2201-1 - Members of the Armed Forces dying during an induction period.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 14 2011-04-01 2010-04-01 true Members of the Armed Forces dying during an... Miscellaneous § 20.2201-1 Members of the Armed Forces dying during an induction period. (a) The additional...) (see paragraph (b) of this section) and while in active service as a member of the Armed Forces of...

  14. Imagining the Alternatives to Life Prolonging Treatments: Elders' Beliefs about the Dying Experience

    ERIC Educational Resources Information Center

    Winter, Laraine; Parker, Barbara; Schneider, Melissa

    2007-01-01

    Deciding for or against a life-prolonging treatment represents a choice between prolonged life and death. When the death alternative is not described, individuals must supply their own assumptions. How do people imagine the experience of dying? The authors asked 40 elderly people open-ended questions about dying without 4 common life-prolonging…

  15. 38 CFR 11.128 - Veteran dies without having filed application for final settlement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... having filed application for final settlement. 11.128 Section 11.128 Pensions, Bonuses, and Veterans... Amended (pub. L. 120, 68th Cong.) § 11.128 Veteran dies without having filed application for final settlement. If the veteran dies without having filed application for final settlement under the...

  16. 78 FR 38682 - Information Collection; Application for Payment of Amounts Due Persons Who Have Died, Disappeared...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ...; Application for Payment of Amounts Due Persons Who Have Died, Disappeared, or Have Been Declared Incompetent... Amounts Due Persons Who Have Died, Disappeared, or Have Been Declared Incompetent. OMB Control Number... declared incompetent must complete a form FSA-325, Application for Payment of Amounts Due Persons Who...

  17. Self-Determination, the Right to Die, and Culture: A Literature Review

    ERIC Educational Resources Information Center

    McCormick, Andrew J.

    2011-01-01

    Self-determination is a primary ethical principle underlying social work practice in health care settings. Since the 1970s, a right-to-die movement that shares the social work commitment to self-determination has grown and influences end-of-life care decisions. However, the role of culture is notably absent in discussions of the right to die. A…

  18. Health Care Providers and Dying Patients: Critical Issues in Terminal Care.

    ERIC Educational Resources Information Center

    Benoliel, Jeanne Quint

    1988-01-01

    Identifies three major areas of concern in relationship between health care providers and dying patients: (1) nature of difficulties and stresses associated with terminal care; (2) education of providers for work; and (3) influence of organizational structure and institutionalized values on services for dying patients and families. Reviews…

  19. Death Anxiety Reduction as the Result of Exposure to a Death and Dying Symposium.

    ERIC Educational Resources Information Center

    Waldman, David A.; Davidshofer, Charles

    1984-01-01

    Measured the effect of a three-week death and dying symposium on attitudes and anxiety related to death, dying, and grief. Results indicated lower death anxiety for students in both the treatment and control groups. Findings are discussed in terms of widespread media coverage and informal discussions which accompany symposiums. (JAC)

  20. Facilitating Attachment between School-Aged Children and a Dying Parent

    ERIC Educational Resources Information Center

    Saldinger, Amy; Cain, Albert C.; Porterfield, Katherine; Lohnes, Kelly

    2004-01-01

    A qualitative, community study of 58 parentally bereaved children and their 35 surviving parents illustrates how families take advantage of forewarning of death to foster connections between children and dying parents and prepare for youngsters' continued attachment to dying parents after the death. Children and parents displayed strong yearnings…

  1. Matthias Falter und die frühe Halbleitertechnik in der DDR

    NASA Astrophysics Data System (ADS)

    Dittmann, Frank

    Nach einer ganzen Reihe von Vorarbeiten weltweit1 konnten im Dezember 1947 die amerikanischen Physiker Walter H. Brattain, John Bardeen und William Shockley in den Bell Laboratories den Transistoreffekt demonstrieren. Damit legten sie den Grundstein für die Mikroelektronik als Basistechnologie des Informationszeitalters.

  2. Communication Education as Social Support: Teaching Families with a Dying Member.

    ERIC Educational Resources Information Center

    Morgan, Steven D.

    Teaching communication skills to families with a dying member presents unique challenges. As M. R. Parks' critique of interpersonal communication literature suggests, it is important to keep in mind the larger social context surrounding the person dying and to maintain a balanced perspective of information exchange (e.g., self-disclosure) and…

  3. Are people with HIV in London able to die where they plan?

    PubMed

    Guthrie, B; Nelson, M; Gazzard, B

    1996-12-01

    Being able to die where you plan is a measure of quality of life near death, in that it implies awareness of diagnosis and prognosis, adequate symptom control and involvement in decision-making in late-stage HIV disease. This study presents trends in place of death for patients attending a large central London HIV centre and examines whether patients dying over a 6-month period in 1994 were able to die where they planned. Early in the epidemic almost all people with HIV died in hospital, but in the late 1980s there was an increase in death at home and in hospices. Of people attending this hospital in 1994, 46% died in hospital, 31% at home, 20% in hospices and 2% abroad. A total of 59% of deaths were where the dying person had planned. Most unplanned deaths were in hospital, two-thirds being due to an unexpected deterioration which precluded planning. The rest were a mixture of people waiting for discharge to die elsewhere, and people who wished to continue active treatment. This pattern of place of death is unlikely to change in the near future. It is therefore essential that hospitals can provide for the needs of patients dying on acute wards.

  4. Numerical investigation of the effect of friction conditions to increase die life

    NASA Astrophysics Data System (ADS)

    Mutlu, M. O.; Guleryuz, C. G.; Parlar, Z.

    2017-02-01

    The standard die materials in aluminium extrusion offer good mechanical properties like high tempering resistance, high strength and ductility. On the other hand, they struggle with the problem of sliding wear. As a result, there is a growing interest in using surface treatment techniques to increase the wear resistance of extrusion dies. In this study, it is aimed to observe the effects of the different friction conditions on material flow and contact pressure in extrusion process. These friction conditions can be obtained with the application of a variety of surface treatment. In this way, it is expected to decrease the friction force on the die bearing area and to increase the homogeneity of the material flow which will result in the increase of the quality of the extrudate as well as the improvement of the process economically by extending die life. For this purpose, an extrusion process is simulated with a finite element software. A die made of 1.2344 hot work tool steel-commonly used die material for aluminium extrusion process- has been modelled and Al 1100 alloy used as billet material. Various friction factor values defined on the die surface under the same process parameters and effects of changing frictional conditions on the die and the extrusion process have been discussed.

  5. Development and Testing of a New Instrument for Measuring Concerns about Dying in Health Care Providers

    ERIC Educational Resources Information Center

    Mazor, Kathleen M.; Schwartz, Carolyn E.; Rogers, H. Jane

    2004-01-01

    A new measure of concerns about dying was investigated in this psychometric study. The Concerns About Dying instrument (CAD) was administered to medical students, nursing students, hospice nurses, and life sciences graduate students ( N = 207) on two occasions; on one occasion they also completed three related measures. Analyses included…

  6. Two Decades of Research on Dying: What Do We Know About the Patient?

    ERIC Educational Resources Information Center

    Schultz, Richard; Schlarb, Janet

    1988-01-01

    Reviews literature on terminal patients and nature of their experiences during the time before their death by examining: (1) the number of persons each year who must confront their own death; (2) emotional responses of dying patients to their impending death; (3) interventions for the dying patient; and (4) areas for future research. (Author/NB)

  7. 26 CFR 20.2201-1 - Members of the Armed Forces dying during an induction period.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 14 2012-04-01 2012-04-01 false Members of the Armed Forces dying during an... Miscellaneous § 20.2201-1 Members of the Armed Forces dying during an induction period. (a) The additional...) (see paragraph (b) of this section) and while in active service as a member of the Armed Forces of...

  8. 26 CFR 20.2201-1 - Members of the Armed Forces dying during an induction period.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 14 2013-04-01 2013-04-01 false Members of the Armed Forces dying during an... Miscellaneous § 20.2201-1 Members of the Armed Forces dying during an induction period. (a) The additional...) (see paragraph (b) of this section) and while in active service as a member of the Armed Forces of...

  9. 26 CFR 20.2201-1 - Members of the Armed Forces dying during an induction period.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 14 2014-04-01 2013-04-01 true Members of the Armed Forces dying during an... Miscellaneous § 20.2201-1 Members of the Armed Forces dying during an induction period. (a) The additional...) (see paragraph (b) of this section) and while in active service as a member of the Armed Forces of...

  10. HUBBLE FINDS THOUSANDS OF GASEOUS FRAGMENTS SURROUNDING DYING STAR

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Resembling a bizarre setting from a science fiction movie, dramatic images sent back by NASA's Hubble Space Telescope have surprised astronomers by uncovering thousands of gigantic tadpole-shaped objects surrounding a dying star. Dubbed 'cometary knots' because their glowing heads and gossamer tails superficially resemble comets, they are probably the result of a dying star's final outbursts. Though ground-based telescopic observations have hinted at such objects, they have not previously been seen in such abundance, say researchers. The knots were detected by Hubble astronomer C. Robert O'Dell and graduate student Kerry P. Handron of Rice University in Houston, Texas, while exploring the Helix nebula, a ring of glowing gases blown off the surface of a sunlike star late in its life. O'Dell expects the gaseous knots, which are each several billion miles across, will eventually dissipate and vanish into the cold emptiness of interstellar space. However, he speculates that if the objects contract to form permanent solid bodies, they may contribute to a fraction (less than ten percent) of the missing mass of our galaxy, simply because of their sheer abundance around a typical dying star. (This so-called dark matter is a known source of gravity that affects the motions of stars in the galaxy). The mysterious 'space pods' came into view as O'Dell used Hubble's Wide Field Planetary Camera 2 to survey the Helix nebula, located 450 light-years away in the constellation Aquarius and the closest planetary nebula to Earth -- so close that its angular size is almost half that of the full Moon. The most visible cometary knots all lie along the inner edge of the ring, at a distance of trillions of miles from the central star. Their comet-like tails, each stretching a hundred billion miles, form a radial pattern around the star like the spokes on a wagon wheel. Though previous ground-based observations show a spoke pattern in the Helix, and some structure, O'Dell emphasizes that

  11. Understanding cultural difference in caring for dying patients.

    PubMed Central

    Koenig, B A; Gates-Williams, J

    1995-01-01

    Experiences of illness and death, as well as beliefs about the appropriate role of healers, are profoundly influenced by patients' cultural background. As the United States becomes increasingly diverse, cultural difference is a central feature of many clinical interactions. Knowledge about how patients experience and express pain, maintain hope in the face of a poor prognosis, and respond to grief and loss will aid health care professionals. Many patients' or families' beliefs about appropriate end-of-life care are easily accommodated in routine clinical practice. Desires about the care of the body after death, for example, generally do not threaten deeply held values of medical science. Because expected deaths are increasingly the result of explicit negotiation about limiting or discontinuing therapies, however, the likelihood of serious moral disputes and overt conflict increases. We suggest a way to assess cultural variation in end-of-life care, arguing that culture is only meaningful when interpreted in the context of a patient's unique history, family constellation, and socioeconomic status. Efforts to use racial or ethnic background as simplistic, straightforward predictors of beliefs or behavior will lead to harmful stereotyping of patients and culturally insensitive care for the dying. PMID:7571587

  12. Kill or Die: Moral Judgment Alters Linguistic Coding of Causality.

    PubMed

    De Freitas, Julian; DeScioli, Peter; Nemirow, Jason; Massenkoff, Maxim; Pinker, Steven

    2017-02-02

    What is the relationship between the language people use to describe an event and their moral judgments? We test the hypothesis that moral judgment and causative verbs rely on the same underlying mental model of people's actions. Experiment 1a finds that participants choose different verbs to describe the major variants of a moral dilemma, the trolley problem, mirroring differences in their wrongness judgments: they described direct harm with a single causative verb (Adam killed the man), and indirect harm with an intransitive verb in a periphrastic construction (Adam caused the man to die). Experiments 1b and 2 separate physical causality from moral valuation by varying whether the victim is a person or animal and whether the harmful action rescues people or inanimate objects. The results show that people's moral judgments lead them to portray a causal event as either more or less direct and intended, which in turn shapes their verb choices. Experiment 3 finds the same basic asymmetry in verb usage in a production task in which participants freely described what happened. (PsycINFO Database Record

  13. Why So Many More Americans Die in Fires

    NASA Astrophysics Data System (ADS)

    Cranberg, Lawrence

    2009-03-01

    ``Why So Many More Americans Die in Fires'' is the headline on Page 3 of The New York Times' full-page story on December 22, l991, by D. G. McNeil, Jr. This is a partial report based on personal experience with domestic fire making for thermal comfort since l975 (1) and a published claim (2) of unique safety benefits.The McNeil report attributes the problem to ``A Case of Bad Attitude'' and ``A Reliance on Technology.'' That implies a ``bad attitude'' on the part of technologists - a conclusion consistent with this technologist's thirty-five years of experience with fellow technologists, who has found ``buck-passing'' the favorite recourse of technologists in the highest places in government even though, as McNeil has written, ``Many children never wake up. Smoke or toxic gases overcome them as they sleep. When fire fighters lift them, their imprints remain.'' Regrettably, in this author's experience, the courts have also displayed a ``bad attitude'' where ``life and death issues'' have been pleaded. 1. L. Cranberg, Slot Flame Stablity with Hohlraum Radiation Pattern, BAPS, Series II, Vol. 20, No. 9, Sept., l978. 2. L. Cranberg, Fireplace Firesafety, Fire Journal, Letter, May/June,l987

  14. A framework for integrated pediatric palliative care: being with dying.

    PubMed

    Rushton, Cynda Hylton

    2005-10-01

    Recent studies highlight the need for an integrated model for palliative and end-of-life pediatric care. About 55,000 children die each year in the United States and, on any given day, about 8,600 children could benefit from care that acknowledges their limited life expectancy and severity of illness. Two case studies of children illustrate different approaches-one that aggressively applies all possible technologies to maximize chances of survival and another that focuses on the patient's overall quality of life and on healing rather than curing. The cases highlight characteristics of an integrated model of palliative care to address clinical, moral, and ethical uncertainties. This model integrates being with doing, provides for developing attunement and presence as capacities for being with children and their parents, and addresses challenges in the healthcare environment. Strategies for integrating palliative care into pediatric practice include listening, fostering respect for the child and parents across the organization, nurturing collaborative connections, managing uncertainty, tolerating ambiguity, making peace with conflict, and committing to self-care. Every pediatric nurse can play a role in making the vision of palliative care a reality integrated into the fabric of pediatric practice.

  15. e-Government for Development Information Exchange (DIE): Zambia

    NASA Astrophysics Data System (ADS)

    Joseph, Bwalya Kelvin

    In most parts of the world, political systems which utilize authoritative rule and mostly employ top-down decision-making processes are slowly transcending towards democratic norms. Information Technology Systems have been identified and adopted as one of the most efficient vehicles for appropriate, transparent and inclusive / participatory decision making. Zambia has shown a higher propensity to indigenous knowledge systems which are full of inefficiencies, a lot of red tape in public service delivery, and prone to corrupt practices. Despite that being the case, it is slowly trying to implement e-government. The adoption of e-government promises a sharp paradigm shift where public institutions will be more responsive and transparent, promote efficient PPP (Public Private Partnerships), and empower citizens by making knowledge and other resources more directly accessible. This paper examines three cases from Zambia where ICT in support of e-government has been implemented for Development Information Exchange (DIE) - knowledge-based decision making. The paper also assesses the challenges, opportunities, and issues together with e-government adoption criteria regarding successful encapsulation of e-government into the Zambian contextual environment. I propose a conceptual model which offers balanced e-government adoption criteria involving a combination of electronic and participatory services. This conceptual e-government adoption model can later be replicated to be used at the Southern African Development Community (SADC) level given the similarity in the contextual environment.

  16. HUBBLE FINDS THOUSANDS OF GASEOUS FRAGMENTS SURROUNDING DYING STAR

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Resembling a bizarre setting from a science fiction movie, dramatic images sent back by NASA's Hubble Space Telescope have surprised astronomers by uncovering thousands of gigantic tadpole-shaped objects surrounding a dying star. Dubbed 'cometary knots' because their glowing heads and gossamer tails superficially resemble comets, they are probably the result of a dying star's final outbursts. Though ground-based telescopic observations have hinted at such objects, they have not previously been seen in such abundance, say researchers. The knots were detected by Hubble astronomer C. Robert O'Dell and graduate student Kerry P. Handron of Rice University in Houston, Texas, while exploring the Helix nebula, a ring of glowing gases blown off the surface of a sunlike star late in its life. O'Dell expects the gaseous knots, which are each several billion miles across, will eventually dissipate and vanish into the cold emptiness of interstellar space. However, he speculates that if the objects contract to form permanent solid bodies, they may contribute to a fraction (less than ten percent) of the missing mass of our galaxy, simply because of their sheer abundance around a typical dying star. (This so-called dark matter is a known source of gravity that affects the motions of stars in the galaxy). The mysterious 'space pods' came into view as O'Dell used Hubble's Wide Field Planetary Camera 2 to survey the Helix nebula, located 450 light-years away in the constellation Aquarius and the closest planetary nebula to Earth -- so close that its angular size is almost half that of the full Moon. The most visible cometary knots all lie along the inner edge of the ring, at a distance of trillions of miles from the central star. Their comet-like tails, each stretching a hundred billion miles, form a radial pattern around the star like the spokes on a wagon wheel. Though previous ground-based observations show a spoke pattern in the Helix, and some structure, O'Dell emphasizes that

  17. Fissile Material Detection by Differential Die Away Analysis

    NASA Astrophysics Data System (ADS)

    Shaw, Timothy J.; Strellis, Dan A.; Stevenson, John; Keeley, Doug; Gozani, Tsahi

    2009-03-01

    Detection and interdiction of Special Nuclear Material (SNM) in transportation is one of the most critical security issues facing the United States. Active inspection by inducing fission in fissile nuclear materials, such as 235U and 239Pu, provides several strong and unique signatures that make the detection of concealed nuclear materials technically very feasible. Differential Die-Away Analysis (DDAA) is a very efficient, active neutron-based technique that uses the abundant prompt fission neutrons signature. It benefits from high penetrability of the probing and signature neutrons, high fission cross section, high detection sensitivity, ease of deployment and relatively low cost. DDAA can use any neutron source or energy as long as it can be suitably pulsed. The neutron generator produces pulses of neutrons that are directed into a cargo. As each pulse passes through the cargo, the neutrons are thermalized and absorbed. If SNM is present, the thermalized neutrons create a new source of (fission) neutrons with a distinctive time profile. An efficient laboratory system was designed, fabricated and tested under a US Government DHS DNDO contract. It was shown that a small uranium sample can be detected in a large variety of cargo types and configurations within practical measurement times using commercial compact (d,T) sources. Using stronger sources and wider detector distribution will further cut inspection time. The system can validate or clear alarms from a primary inspection system such as an automated x-ray system.

  18. Fissile Material Detection by Differential Die Away Analysis

    SciTech Connect

    Shaw, Timothy J.; Strellis, Dan A.; Stevenson, John; Keeley, Doug; Gozani, Tsahi

    2009-03-10

    Detection and interdiction of Special Nuclear Material (SNM) in transportation is one of the most critical security issues facing the United States. Active inspection by inducing fission in fissile nuclear materials, such as {sup 235}U and {sup 239}Pu, provides several strong and unique signatures that make the detection of concealed nuclear materials technically very feasible. Differential Die-Away Analysis (DDAA) is a very efficient, active neutron-based technique that uses the abundant prompt fission neutrons signature. It benefits from high penetrability of the probing and signature neutrons, high fission cross section, high detection sensitivity, ease of deployment and relatively low cost. DDAA can use any neutron source or energy as long as it can be suitably pulsed. The neutron generator produces pulses of neutrons that are directed into a cargo. As each pulse passes through the cargo, the neutrons are thermalized and absorbed. If SNM is present, the thermalized neutrons create a new source of (fission) neutrons with a distinctive time profile. An efficient laboratory system was designed, fabricated and tested under a US Government DHS DNDO contract. It was shown that a small uranium sample can be detected in a large variety of cargo types and configurations within practical measurement times using commercial compact (d,T) sources. Using stronger sources and wider detector distribution will further cut inspection time. The system can validate or clear alarms from a primary inspection system such as an automated x-ray system.

  19. Evaluation of a Heat Flux Sensor for Spray Cooling for the Die Casting Processes

    SciTech Connect

    Sabau, Adrian S; Wu, Zhuoxi

    2007-02-01

    During the die casting process, lubricants are sprayed in order to cool the dies and facilitate the ejection of the casting. In this paper, a new technique for measuring the heat flux during lubricant application is evaluated. Data from experiments conducted using water spray are first presented. Water spray experiments were conducted for different initial plate temperatures. Measurements were conducted for the application of two different lubricants, of dilution ratios of 1/15 and 1/50 of lubricant in water. The measurement uncertainties were documented. The results show that the surface temperature decreases initially very fast. Numerical simulation results confirmed that the abrupt temperature drop is not an artifact but illustrates the thermal shock experienced by the dies during the initial stages of lubricant application. The lubricant experiments show that the sensor can be successfully used for testing die lubricants with typical dilution ratios encountered in the die casting process.

  20. Evaluation of the Pressing Characteristics of Commercially Pure Titanium Using an Instrumented Double Acting Die

    SciTech Connect

    Hovanski, Yuri; Lavender, Curt A.; Weil, K. Scott

    2008-06-19

    With recent advances in synthesizing titanium powder by low-cost routes, there has been growing interest in identifying process/material conditions that overcome the powder compaction problems typically found with this reactive metal. The use of instrumented dies in studying the cold pressing process for commercial iron and steel powders has provided greater insight into the complex phenomena that occur and may be used to evaluate constitutive relations that describe the compaction process. Nevertheless, little work has been conducted on the special, more problematic case of reactive metal powders such as titanium. An instrumented die was developed that allows die wall friction to be characterized and the radial stress distribution along the die wall and throughout the compact to be monitored. As will be presented, this tool has been used to investigate titanium compaction and to draw comparisons with results obtained on a baseline commercial iron powder. Both sets of data were systematically collected using various powder/die lubrication combinations.

  1. The Influence of Anxiety Sensitivity on a Wish to Die in Complicated Grief.

    PubMed

    Baker, Amanda W; Goetter, Elizabeth M; Bui, Eric; Shah, Riva; Charney, Meredith E; Mauro, Christine; Shear, M Katherine; Simon, Naomi M

    2016-04-01

    Individuals with complicated grief are at elevated risk of suicidal thoughts. Anxiety sensitivity has recently emerged as a risk factor of suicide. This study aimed to investigate a possible association between anxiety sensitivity and a wish to die in individuals with complicated grief. Participants were evaluated for participation in a treatment study and completed an ancillary questionnaire-based study. Participants were 51 bereaved adults evaluated (age: mean, 54 [SD, 13.6] years; 78% [n = 40] women). Logistic regression was used to examine the relationship between anxiety sensitivity and a wish to die. Overall, anxiety sensitivity was associated with a wish to die at the level of a medium effect size, although it did not reach statistical significance. The anxiety sensitivity social concerns subscale was significantly associated with a wish to die. These findings add to a growing literature implicating anxiety sensitivity in reporting a wish to die.

  2. Spatio-temporal development of vegetation die-off in a submerging coastal marsh

    USGS Publications Warehouse

    Schepers, Lennert; Kirwan, Matthew; Guntenspergen, Glenn R.; Temmerman, Stijn

    2017-01-01

    In several places around the world, coastal marsh vegetation is converting to open water through the formation of pools. This is concerning, as vegetation die-off is expected to reduce the marshes' capacity to adapt to sea level rise by vegetation-induced sediment accretion. Quantitative analyses of the spatial and temporal development of marsh vegetation die-off are scarce, although these are needed to understand the bio-geomorphic feedback effects of vegetation die-off on flow, erosion, and sedimentation. In this study, we quantified the spatial and temporal development of marsh vegetation die-off with aerial images from 1938 to 2010 in a submerging coastal marsh along the Blackwater River (Maryland, U.S.A). Our results indicate that die-off begins with conversion of marsh vegetation into bare open water pools that are relatively far (> 75 m) from tidal channels. As vegetation die-off continues, pools expand, and new pools emerge at shorter and shorter distances from channels. Consequently larger pools are found at larger distances from the channels. Our results suggest that the size of the pools and possibly the connection of pools with the tidal channel system have important bio-geomorphic implications and aggravate marsh deterioration. Moreover, we found that the temporal development of vegetation die-off in moderately degraded marshes is similar as the spatial die-off development along a present-day gradient, which indicates that the contemporary die-off gradient might be considered a chronosequence that offers a unique opportunity to study vegetation die-off processes.

  3. Fundamental studies on a novel die concept for round-point shear-clinching

    NASA Astrophysics Data System (ADS)

    Hörhold, Réjane; Müller, Martin; Merklein, Marion; Meschut, Gerson

    2016-10-01

    A newly-developed round-point shear-clinching technology could increase the use of different materials like well formable aluminium and hardly formable ultra-high-strength steels (UHSS). This innovative technology joins in a single-stage process without any pilot-hole, surface pre-treatment or auxiliary joining part. The combination of an inner and outer punch realises an indirect cutting operation of the die-sided material, whereas the punch-sided material remains unharmed. The current die-sided tool set acts as a cutting die and enables a radial extrusion of the punch-sided material after being drawn though the created hole in the UHSS. The die has a fixed die depth. After ejecting the joined components, the slug has to be removed from the top of the spring-loaded anvil. The novel die concept investigated in this paper offers the possibility to push the slug continuously through the die in the joining direction. The removed slugs remain inside the die, so manual removal is unnecessary. The one-parted tool is supposed to be more robust than the multi-parted one that is currently used. This paper represents the task to evaluate the geometry of a useful shear-clinching die concept. To reduce the experimental effort, FEM should assist the development of the most promising approach. To quantify the success, conventional shear-clinching with opening die acts as a reference. The results show the high potential and the raison d'être of shear-clinching technologies as a mechanical joining technology for future multimaterial applications especially for UHSS.

  4. Ecohydrological consequences of drought- and infestation-triggered tree die-off: insights and hypotheses

    NASA Astrophysics Data System (ADS)

    Adams, H. D.; Luce, C.; Breshears, D. D.; Weiler, M.; Hale, C.; Allen, C. D.; Smith, A. M.; Huxman, T. E.

    2011-12-01

    Widespread, rapid, drought-, and infestation-triggered tree mortality is emerging as a phenomenon affecting forests globally and may be linked to increasing temperatures and drought frequency and severity. The ecohydrological consequences of forest dieoff have been little studied and remain highly uncertain. To explore this knowledge gap, we apply the extensive literature on the ecohydrological effects of tree harvest in combination with the limited existing die-off ecohydrology research to develop new, relevant hypotheses. Tree mortality results in loss of canopy cover, which directly alters evaporation, transpiration, and canopy interception and indirectly alters other watershed hydrologic processes, including infiltration, runoff, groundwater recharge, and streamflow. Both die-off and harvest research suggest that for most forests, water yield can be expected to increase following substantial loss of tree cover by die-off as evapotranspiration and interception are decreased. We hypothesize that where annual precipitation exceeds ~500 mm or water yield is dominated by snowmelt, watersheds will experience significantly decreased evapotranspiration and increased flows if absolute canopy cover loss from die-off exceeds 20%. However, recent observations suggest that water yield following die-off can potentially decrease rather than increase in drier forests. Post-mortality successional dynamics will ultimately determine if short-term die-off impacts to hydrological function will persist, be diminished, or altered further over longer time scales. To reliably predict die-off responses, more research is needed to test these hypotheses, including observations of multiple water budget components and the persistence of ecohydrological effects with the post-die-off successional dynamics of tree recruitment, understory growth, and interactions with additional disturbances. With die-off, mitigation and restoration options are limited and costly, necessitating societal

  5. In the business of dying: questioning the commercialization of hospice.

    PubMed

    Perry, Joshua E; Stone, Robert C

    2011-01-01

    This article critically questions the commercialization of hospice care and the ethical concerns associated with the industry's movement toward "market-driven medicine" at the end of life. For example, the article examines issues raised by an influx of for-profit hospice providers whose business model appears at its core to have an ethical conflict of interest between shareholders doing well and terminal patients dying well. Yet, empirical data analyzing the experience of patients across the hospice industry are limited, and general claims that end-of-life patient care is inferior among for-profit providers or even that their business practices are somehow unseemly when compared to nonprofit providers cannot be substantiated. In fact, non-profit providers are not immune to potentially conflicting concerns regarding financial viability (i.e., "no margin, no mission"). Given the limitations of existing empirical data and contrasting ideological commitments of for-profit versus non-profit providers, the questions raised by this article highlight important areas for reflection and further study. Policymakers and regulators are cautioned to keep ethical concerns in the fore as an increasingly commercialized hospice industry continues to emerge as a dominant component of the U.S. health care system. Both practitioners and researchers are encouraged to expand their efforts to better understand how business practices and commercial interests may compromise the death process of the patient and patient's family--a process premised upon a philosophy and ethical tradition that earlier generations of hospice providers and proponents established as a trusted, end-of-life alternative.

  6. Improved life of die casting dies of H13 steel by attaining improved mechanical properties and distortion control during heat treatment. Year 1 report, October 1994--September 1995

    SciTech Connect

    Wallace, J.F.; Schwam, D.

    1995-03-01

    Optimum heat treatment of dies (quenching) is critical in ensuring satisfactory service performance: rapid cooling rates increase the thermal fatigue/heat checking resistance of the steel, although very fast cooling rates can also lead to distortion and lower fracture toughness, increasing the danger of catastrophic fracture. Goal of this project is to increase die life by using fast enough quenching rates (> 30 F/min ave cooling rate from 1750 to 550 F, 1/2 in. below working surfaces) to obtain good toughness and fatigue resistance in Premium grade H-13 steel dies. An iterative approach of computer modeling validated by experiment was taken. Cooling curves during gas quenching of H-13 blocks and die shapes were measured under 2, 5, and 7.5 bar N2 and 4 bar Ar. Resulting dimensional changes and residual stresses were determined. To facilitate the computer modeling work, a database of H-13 mechanical and physical properties was compiled. Finite element analysis of the heat treated shapes was conducted. Good fit of modeled vs measured quenched rates was demonstrated for simple die shapes. The models predict well the phase transformation products from the quench. There is good fit between predicted and measured distortion contours; however magnitude of predicted distortion and residual stresses does not match well the measured values. Further fine tuning of the model is required.

  7. Manufacture of gradient micro-structures of magnesium alloys using two stage extrusion dies

    SciTech Connect

    Hwang, Yeong-Maw; Huang, Tze-Hui; Alexandrov, Sergei; Naimark, Oleg Borisovich; Jeng, Yeau-Ren

    2013-12-16

    This paper aims to manufacture magnesium alloy metals with gradient micro-structures using hot extrusion process. The extrusion die was designed to have a straight channel part combined with a conical part. Materials pushed through this specially-designed die generate a non-uniform velocity distribution at cross sections inside the die and result in different strain and strain rate distributions. Accordingly, a gradient microstructure product can be obtained. Using the finite element analysis, the forming temperature, effective strain, and effective strain rate distributions at the die exit were firstly discussed for various inclination angles in the conical die. Then, hot extrusion experiments with a two stage die were conducted to obtain magnesium alloy products with gradient micro-structures. The effects of the inclination angle on the grain size distribution at cross sections of the products were also discussed. Using a die of an inclination angle of 15°, gradient micro-structures of the grain size decreasing gradually from 17 μm at the center to 4 μm at the edge of product were achieved.

  8. Design and Analysis of a Forging Die for Manufacturing of Multiple Connecting Rods

    NASA Astrophysics Data System (ADS)

    Megharaj, C. E.; Nagaraj, P. M.; Jeelan Pasha, K.

    2016-09-01

    This paper demonstrates to utilize the hammer capacity by modifying the die design such that forging hammer can manufacture more than one connecting rod in a given forging cycle time. To modify the die design study is carried out to understand the parameters that are required for forging die design. By considering these parameters, forging die is designed using design modelling tool solid edge. This new design now can produce two connecting rods in same capacity hammer. The new design is required to validate by verifying complete filing of metal in die cavities without any defects in it. To verify this, analysis tool DEFORM 3D is used in this project. Before start of validation process it is require to convert 3D generated models in to. STL file format to import the models into the analysis tool DEFORM 3D. After importing these designs they are analysed for material flow into the cavities and energy required to produce two connecting rods in new forging die design. It is found that the forging die design is proper without any defects and also energy graph shows that the forging energy required to produce two connecting rods is within the limit of that hammer capacity. Implementation of this project increases the production of connecting rods by 200% in less than previous cycle time.

  9. Jade and the journalists: media coverage of a young British celebrity dying of cancer.

    PubMed

    Walter, Tony

    2010-09-01

    In contemporary western societies, dying usually occurs in old age, out of sight in hospitals and institutions; how then do lay people learn what dying is like? Since the 1970s, one source of information in Anglophone societies has come from individuals who have chosen to publicise their dying of cancer. This article examines the most high profile case of this to date in the UK; in 2009, celebrity Jade Goody publicised in tabloid newspapers and celebrity magazines the final weeks of her dying of cervical cancer. What did she and her media say and write about dying? This article examines the print coverage of her final weeks, and four different voices are identified: those of Goody, of journalists, of her publicist, and of photographers, each representing her dying somewhat differently. Two major themes are discussed: Jade's struggles to retain autonomy (challenged by her disease and by other people), and the framing of her final weeks not primarily as a typical media cancer story of heroism, but as one of redemption in which she attained social respectability through dying.

  10. Fabrication of glass photonic crystal fibers with a die-cast process.

    PubMed

    Guiyao, Zhou; Zhiyun, Hou; Shuguang, Li; Lantian, Hou

    2006-06-20

    We demonstrate a novel method for the fabrication of glass photonic crystal fibers (PCFs) with a die-cast process. SF6 glass is used as the material for PCFs, and the die is made of heat-resisting alloy steel, whose inner structure matches the PCF's structure. The die is put vertically in the vessel with SF6 glass, and the vacuum hose is attached to the top of the die. The die and glass are put in the furnace to heat at 870 K. The die is slowly filled with the softening glass under vacuum conduction until it is full. It is kept in the furnace to anneal at a rate of 20 K/h to remove the thermal stress that could lead to cracks. The outer tube of the die is taken apart when its temperature is close to room temperature, and the fused glass bundle is etched in an acidic solution to remove the heat-resisting alloy steel rods. Thus, the etched bundle is ready to use as a PCF preform. The PCF is observed in the generation of a supercontinuum, with the flat plateau in the spectrum of the output emission stretching from 400 to 1400 nm by experimental measurement. The transmission loss is 0.2-0.3 dB/m at wavelengths of 420-900 nm.

  11. Nursing the dying: implications of Kübler-Ross' staging theory.

    PubMed

    Germain, C P

    1980-01-01

    Society's failure to value the work of nurses, the professionals most frequently involved in the care of the dying, is attributed to a cultural definition of nursing as a second-class occupation and the public's need to deny the realities of the suffering and indignities often associated with the process of dying. Efforts within the field of nursing to improve the care of the dying, by shifting emphasis from a narrow physical focus to a more holistic patient and family focus, preceded the past decade's contributions of Elisabeth Kübler-Ross. Although her staging theory has been cited as having limitations in development and in interpretation, Kübler-Ross' influence towards increasing awareness of the needs of the dying and others experiencing major losses has been substantial as evidenced by many references to staging theory in nursing literature, by a marked increase in attention to holistic care of the dying in the basic and continuing education programs of nursing, and by specialty role development in nursing care of the dying. This decade has also witnessed the major growth of professionalism in nursing, including strides towards professional autonomy. Conflict with the traditional pattern of medical dominance and bureacratic constraints in institutions is inevitable, especially when the medical goal of cure is not attainable. Change to an interdisciplinary model of care is viewed as essential for optimal care of the dying and their families.

  12. The Influence of Thermal Conductivity of Die Material on the Efficiency of Hot-Stamping Process

    NASA Astrophysics Data System (ADS)

    Li, Shuang; Zhou, Luhai; Wu, Xiaochun; Zhang, Yun; Li, Junwan

    2016-11-01

    To improve the production efficiency of the hot-stamping process from the perspective of the die materials, a numerical model of a B-pillar component was established to investigate the effects of the thermal conductivity of the die material on the cooling behavior, microstructure, and mechanical evolution of the formed component, as well as the temperature distribution of the die during the hot-stamping process. The results showed that the thermal conductivity of the die material has a more significant influence on the quenching stage than the forming stage. Under the specified simulation and boundary conditions, when the thermal conductivity of the die material improves by 76.23% at 25-300 °C, the maximum cooling rate of the component increases by 48.49% and consequently improves the quenching efficiency of the hot-stamping process by 31.82%. As the thermal conductivity of the die steel increases, the maximum temperature of the die decreases and its temperature uniformity improves. Moreover, to improve the efficiency of the hot-stamping process, steels that possess high thermal conductivity at low temperature ranges are favorable.

  13. Determination of Initial Crack Strength of Silicon Die Using Acoustic Emission Technique

    NASA Astrophysics Data System (ADS)

    Chen, Pei-Chi; Su, Yen-Fu; Yang, Shin-Yueh; Liang, Steven Y.; Chiang, Kuo-Ning

    2015-07-01

    The current market demand for high-efficiency, high-performance, small-sized electronic products has focused attention on the use of three-dimensional (3D) integrated circuits (IC) in the design of electronic packaging. Silicon wafers can be ground and polished to reduce their thickness and increase the chip stacking density. However, microcracks can result from the thinning and stacking process or during use of an electronic device over time; therefore, estimation of the cracking strength is an important issue in 3D IC packaging. This research combined the ball breaker test (BBT) with an acoustic emission (AE) system to measure the allowable force on a silicon die. To estimate the initial crack strength of a silicon die, the BBT was combined with finite-element (FE) analysis. The AE system can detect the initial crack and the subsequent bulk failure of the silicon die individually, thus avoiding overestimation of the die strength. In addition, the results of the modified ball breaker test showed that edge chipping did not affect the silicon die strength. However, the failure force and silicon die strength were reduced as the surface roughness of the test specimen increased. Thus, surface roughness must be controlled in the BBT to prevent underestimation of the silicon die strength.

  14. Development and Demonstration of Adanced Tooling Alloys for Molds and Dies

    SciTech Connect

    Kevin M. McHugh; Enrique J. Lavernia

    2006-01-01

    This report summarizes research results in the project Development and Demonstration of Advanced Tooling Alloys for Molds and Dies. Molds, dies and related tooling are used to manufacture most of the plastic and metal products we use every day. Conventional fabrication of molds and dies involves a multiplicity of machining, benching and heat treatment unit operations. This approach is very expensive and time consuming. Rapid Solidifcation Process (RSP) Tooling is a spray-forming technology tailored for producing molds and dies. The appraoch combines rapid solidifcation processing and net-shape materials processing in a single step. An atomized spray of a tool-forming alloy, typically a tool steel, is deposited onto an easy-to-form tool pattern to replicate the pattern's shape and surface features. By so doing, the approach eliminates many machining operations in conventional mold making, significantly reducing cost, lead time and energy. Moreover, rapid solidification creates unique microstructural features by suppressing carbide precipitation and growth, and creating metastable phases. This can result in unique material properties following heat treatment. Spray-formed and aged tool steel dies have exhibited extended life compared to conventional dies in many forming operations such as forging, extrusion and die casting. RSP Tooling technolocy was commercialized with the formation of RSP Tooling, LLC in Solon, Oh.

  15. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  16. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  17. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  18. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  19. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  20. Dying with motor neurone disease, what can we learn from family caregivers?

    PubMed Central

    Ray, Robin A.; Brown, Janice; Street, Annette F.

    2012-01-01

    Abstract Background  Increasingly, people with neurodegenerative illness are cared for at home until close to death. Yet, discussing the reality of dying remains a social taboo. Objective  To examine the ways, family caregivers of people living with motor neurone disease (MND) experienced the dying of their relative and to identify how health practitioners can better prepare families for end‐of‐life care. Design  Secondary analysis was undertaken on data sets generated from two longitudinal qualitative studies employing similar data collection and analysis methods. Combining data sets increased participant numbers in a low incidence disease group. Setting and participants  Primary studies were undertaken with family caregivers in England and Australia. Interview and observational data were collected mostly in home. Participants who discussed dying and death formed the sample for secondary analysis. Results  Combined data revealed four major themes: planning for end of life, unexpected dying, dignity in the dying body and positive end to MND. Despite short survival predictions, discussions among family members about dying were often sporadic and linked to loss of hope. Effective planning for death assisted caregivers to manage the final degenerative processes of dying. When plans were not effectively communicated or enacted, capacity to preserve personhood was reduced. Discussion and Conclusion  Returning death and dying to social discourse will raise the level of community awareness and normalize conversations about end‐of‐life care. Strategies for on‐going, effective communication that facilitates advance care planning among patients, their families and practitioners are essential to improve dying and death for people with MND and their family caregivers. PMID:22512686