Kowal, Sabine; O'Connell, Daniel C
The following article presents basic concepts and methods of Ragnar Rommetveit's (born 1924) hermeneutic-dialogical approach to everyday spoken dialogue with a focus on both shared consciousness and linguistically mediated meaning. He developed this approach originally in his engagement of mainstream linguistic and psycholinguistic research of the 1960s and 1970s. He criticized this research tradition for its individualistic orientation and its adherence to experimental methodology which did not allow the engagement of interactively established meaning and understanding in everyday spoken dialogue. As a social psychologist influenced by phenomenological philosophy, Rommetveit opted for an alternative conceptualization of such dialogue as a contextualized, partially private world, temporarily co-established by interlocutors on the basis of shared consciousness. He argued that everyday spoken dialogue should be investigated from within, i.e., from the perspectives of the interlocutors and from a psychology of the second person. Hence, he developed his approach with an emphasis on intersubjectivity, perspectivity and perspectival relativity, meaning potential of utterances, and epistemic responsibility of interlocutors. In his methods, he limited himself for the most part to casuistic analyses, i.e., logical analyses of fictitious examples to argue for the plausibility of his approach. After many years of experimental research on language, he pursued his phenomenologically oriented research on dialogue in English-language publications from the late 1980s up to 2003. During that period, he engaged psycholinguistic research on spoken dialogue carried out by Anglo-American colleagues only occasionally. Although his work remained unfinished and open to development, it provides both a challenging alternative and supplement to current Anglo-American research on spoken dialogue and some overlap therewith.
Gorski, P; Goetz, W
For the development of the therapy using electricity as agent two tracks can be identified. On the one side, the indication for applying this therapy was handled more careful, simultaneously the technical equipment was improved. The Polish noble man Alexander Sapieha (1773-1812), the leading natural scientist of the Granddukedom of Warsaw, cooperated with excellent European scientists in order to improve the galvanic battery technologically. Among these scientists were Alexander Volta (1745-1827), the inventor of the battery, and Johann Bartholomaeus Trommsdorff (1770-1837), who is considered as one of the founders of scientific pharmacy in Europe. A. Sapieha supported the publication of galvanic experiences, e.g. in the case of Alexander of Humboldt (1769-1859) by publishing his paper about electric fishes. Sapiehas connections with the scientific centers in Turin and Bologna, Erfurt, Warszaw and Paris accelerated the exchange of information about galvanism. Later the resulting mini-batteries were employed in diathermie, in defibrillators and pacemakers. Details about these connections are presented in the lecture resp. full paper.
Nunes-Freitas, A F; Rocha, C F D
Canistropsis microps (Bromeliaceae: Bromelioideae) is an endemic species of Atlantic rain forest areas in Rio de Janeiro State, which are very abundant in not very disturbed forests in Ilha Grande, on the southern coast of the State. In this study, we analyzed the vertical and horizontal distribution patterns of the species in an area of rain forest with little evidence of disturbance at Vila Dois Rios, Ilha Grande, relating the patterns to sunlight in the microhabitat. We also identified the types of substrate used by the species and the rate of asexual reproduction. Canistropsis microps had high densities (estimated at 84,425 rosettes/ha), and has an aggregated distribution (Id = 2.86). About 80% of the rosettes were generated by clonal growth, whereas less than 20% were produced from seedlings. Most of the rosettes were found on straight tree trunks (DBH > 50 cm). There was a significant inverse correlation between the incidence of sunlight in the habitat and the abundance of individuals. Rosettes were found up to a maximum height of 9.5 m, but most occured between 1.5 and 5.5 m, where light varied from 25 to 50 micromol x s(-1) x m(-2). We conclude that vertical and horizontal distribution patterns in C. microps may be partially explained by the occurrence of appropriate substrate, an intensity of sunlight favorable to the development of the species and to a high rate of vegetative reproduction.
Organization Name(s) and Address(es) Tampere University of Technology Ragnar Granit Institute Tampere, Finland Performing Organization Report Number...has been supported by the Ragnar Granit Foundation. REFERENCES  J. Malmivuo and R. Plonsey, Bioelectromagnetism - Principles and...SENSITIVITY DISTRIBUTIONS OF EEG AND MEG MEASUREMENTS J. A. Malmivuo1, V. Suihko2 1Ragnar Granit Institute, Tampere University of Technology
Takano, P. Laarne, J. Malmivuo Ragnar Granit Institute, Tampere University of Technology, Finland Abstract – The ECG inverse problem is a...Performing Organization Name(s) and Address(es) Ragnar Granit Institute, Tampere University of Technology, Finland Performing Organization Report Number...computational load for calculating ECG inverse solutions. ACKNOWLEDGMENTS This work has been kindly supported by The Ragnar Granit Foundation, The
Organization Name(s) and Address(es) Ragnar Granit Institute, Tampere University of Technology, Tampere, Finland Performing Organization Report...Kuurne2 H. J. Eskola3 J. A. Malmivuo1 1Ragnar Granit Institute, Tampere University of Technology, Tampere, Finland 2Department of Neurosurgery
Puurtinen, Pasi Kauppinen, Jari Hyttinen, Jaakko Malmivuo Ragnar Granit Institute, Tampere University of Technology, Tampere Finland abstract - ECG...Program Element Number Author(s) Project Number Task Number Work Unit Number Performing Organization Name(s) and Address(es) Ragnar Granit
followed in Sweden . All together the Americans were impressed by our civilian defense, and the report in Life on "Operation Granite " caused unanimous...space. -ng RAGNAR NILSSON LFollowing is a translation of a newspaper article in Svenska Dagbladet, Stockholm, November 5, 19587 They Change Our Lives... Ragnar Nilsson, professor of microbiology and from 1943 to August 1 this year director of the College of Agriculture, was born in Varmland in 1905. He
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Tsai, Jack; Rosenheck, Robert A
Administrative data on the population of Department of Veterans Affairs (VA) service users in 2010 under the age of 65 (n = 3,841,225) were analyzed to identify the number and characteristics of homeless and nonhomeless VA service users who are likely to be eligible for the Medicaid expansion (LEME) option under the Affordable Care Act. Results showed that, estimating conservatively, about 1.2 million (21%) current VA users are LEME if all states implement the expansion. Homeless service users were twice as likely to be eligible than nonhomeless users (64% vs 30%). VA service users who are LEME, regardless of housing status, were physically healthier than those not LEME but were more likely to have substance use disorders and posttraumatic stress disorder. These findings suggest that many VA service users are LEME, particularly those who are homeless and/or have mental health needs. Cross-system use of VA and Medicaid-funded services may be advantageous for veterans with extensive medical and psychiatric needs but also risks fragmented care. Information and education for VA clinicians and their patients about possible implications of the Affordable Care Act may be important.
Williams, Leslie K.
Research indicates that approximately 70% of college students engage in some form of cheating (Austin, Simpson, & Reynen, 2005; Bowers, 1964; Leming; 1978; McCabe & Trevino, 1993, 1996; McCabe, Trevino, & Butterfield, 2001a). College students overwhelmingly agree that cheating is morally wrong; yet, their actions are not reflective of…
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Approach to Relaxation in Glassy Materials bya by DTIC Et. ECTE Karina Weron M A. and S "z’ Aleksander Weron ApptovC fcv - " Technical Report No. 82...STATISTICAL APPROACH TO RELAXATION IN GLASSY MATERIALS 12. PERSONAL AUTHOR(S) Karina Weron and Aleksander Weron 13.. TYPE OF REPORT 13b. TIME COVERED 14. DATE...CLASSIFICATION OF THIS PAGE A Statistical Approach to Relaxation in Glassy Materials1 Karina Weron Institute of Physics Technical University of Wroclaw 50-370
Gomiero, L M; Carmassi, A L; Rondineli, G R; Villares Junior, G A; Braga, F M S
The growth and mortality parameters were estimated through the analysis of length frequency distribution for species of Cichla spp. introduced into a lake in Leme (SP), and in Volta Grande reservoir (SP-MG). In Leme, Cichla kelberi presented larger frequency in the inferior classes of lengths, larger instantaneous rate of natural mortality, and smaller number of cohorts than C. kelberi and C. piquiti in Volta Grande. The values of growth performance obtained for the species were similar, corroborating the validity of the estimated growth and mortality parameters. The increase of the growth rate in small and less diverse environments occurs due to predation. The genus Cichla adapts well in locations in which it is introduced, however this adaptation shows itself to be strongly adjusted to each particular location, determining great plasticity and establishment capacity.
categorization. 1b. Interactions among different m csea . The work on selectivity can be viewed in a slightly different way - the generlizatim depends upon...paper on this accepted in Journal of Experimental Psychology: Learning, Memory, and Cognition (Spalding & Ross, in press) and have presented this work at...the separation of similarity effects. Journal of Expcimentygholog. Leming. Mm=. and Cogntion, 13, 629- 639. Ross, B. H. (1989a). Remindings in learning
magnetooptic films, thermoplast media, and electrooptical crystals were tried. Particular hope was placed in photochrome materials. In our country the...institute, says, "The enormous interest in photochrome materials arose thanks to one amazing property. If, for example, photochrome is illuminated with...possess photochromism ." They say that the troops of Aleksander the Great wore armbands impregnated with a photochrome solution. The change in the
Contribution to the Doctrine Governing Hospitalization in Nationwide Defensive Warfare (1). Wartime Military Medical Equipment for Care of the Sick (2). Present-Day Trends in the Development of Chemical Weapons (3). Pharmacological and Toxicological Properties of Present-Day Combat Poisons Which Cause Malaise (CS, CR)
Lieutenant Colonel SGeneral lvr. KralJ, doctor SFactors exerting an essential effect on the d~biens-JLons, strutcture and ter’ritorial placement of -the...THE SICK Medical Colonel Aleksander lhranilovic, docent and graduate pharmacist, and Medical Colonel Ivan Palmar, docent and doctor The process of...Nedeljko Rosic, doctor , Medical Lieutenant Colonel Radivoje KIusic, docent and ’I doctor , Medical Lieutenant Colonel Bogdan Boskovic, docent and doctor
ADDRESS ,Cit.. State and ZIP Code) 7b. ADDRESS fCity. Slate and ZIP Code, Lowell MA 01854 7" .:a-ri-.a-zai & r.a .. . E -nces, B :_ing ...2 .. -- 0332 Be...LEME’JTARY NCTATION 17 COSATI cOES 1S S..,EECT TERMS sContinue on reverse if necesary- and identify bybkc numberji I.. GRU SB Grelfand- Levitan Equatior...Eigenfunctions Associated with the Gel’fand- Levitan Equation’-* J. Math. Phys., 25, i, 108, January 1984. .""Phases of Complex Functions from the
Kovalev, A V; Molin, Yu A; Gorshkov, A N; Smolyanitsky, A G; Mazurova, E A; Vorontsov, G A
The objective of the present study was to summarize the results of many year investigations on the application of forensic medical methods and experience for the reconstruction of historical events including identification of the ancient Russian saints' hallows and statesmen's remains, elucidation of the genuine causes of death of the members of the Russian Imperial House of Romanovs based on the recently discovered archival materials, restoration of the character of the injuries suffered by Aleksander II, M.I. Kutuzov, P. Demidov, G. Gapon., and G. Rasputin, the attribution A.S. Pushkin's memorial belongings based on the biological traces, and the like.
IN STATISTICAL PHYSICS 0 by Aleksander Weron and Karina Weron Tecnicl Rpor #8Th November 1984) 0 0 85 01 16 099 0 L-SYCLASS1IEA.EDTISAG SfCUAI;V...Stochastic Processes" Department of Statistics J______ University of North Carolina Chapel Hill, NC 27514 f n -- and , -" ::i 7Codes ot : ’r ; Karina Weron...2 p.-t ,i7i;7, ~Department of Physics and Astronomy Louisiana State University Baton Rouge, LA 70803 Abstract. It is shown how a-stable distributions
Heinonen, Tomi; Dastidar, Prasun; Ryymin, Pertti; Lahtinen, Antti J.; Eskola, Hannu; Malmivuo, Jaakko
Quantitative magnetic resonance (MR) imaging of the brain is useful in multiple sclerosis (MS) in order to obtain reliable indices of disease progression. The goal of this project was to estimate the total volume of gliotic and non gliotic plaques in chronic progressive multiple sclerosis with the help of a semiautomatic segmentation method developed at the Ragnar Granit Institute. Youth developed program running on a PC based computer provides de displays of the segmented data, in addition to the volumetric analyses. The volumetric accuracy of the program was demonstrated by segmenting MR images of fluid filed syringes. An anatomical atlas is to be incorporated in the segmentation system to estimate the distribution of MS plaques in various neural pathways of the brain. A total package including MS plaque volume estimation, estimation of brain atrophy and ventricular enlargement, distribution of MS plaques in different neural segments of the brain has ben planned for the near future. Our study confirmed that total lesion volumes in chronic MS disease show a poor correlation to EDSS scores but show a positive correlation to neuropsychological scores. Therefore accurate total volume measurements of MS plaques using the developed semiautomatic segmentation technique helped us to evaluate the degree of neuropsychological impairment.
Aleksander, Igor; Morton, Helen
In this chapter we present a computational architecture intended to add clarity to the concept of consciousness. We briefly review some of the motivations of work done in this area in various institutes around the world and looks closely at our own work which specifically includes phenomenology, the sense of a self in a perceptual world. This breaks consciousness into five axioms: presence, imagination, attention, volition and emotions. It develops plausible mechanisms of each and how they interact to give a single sensation. An abstract architecture, the kernel architecture, is introduced as a starting point for building computational models. It is shown that through this architecture it is possible to discuss puzzling aspects of consciousness, for example are animals conscious? What happens when we dream? What goes on when we experience an illusion? This paper is intended to elucidate and update some concepts introduced in Aleksander (2005).
Silva, Vanessa J D; Ribeiro, Ester M; Luizi-Ponzo, Andrea P; Faria, Ana Paula G
Pollen grain morphology of Bromeliaceae species collected in areas of the Atlantic Rainforest of southeastern Brazil was studied. The following species were analyzed: Aechmea bambusoides L.B.Sm. & Reitz, A. nudicaulis (L.) Griseb., A. ramosa Mart. ex Schult.f., Ananas bracteatus (Lindl.) Schult.f., Billbergia distachia (Vell.) Mez, B. euphemiae E. Morren, B. horrida Regel, B. zebrina (Herb.) Lindl., Portea petropolitana (Wawra) Mez, Pitcairnia flammea Lindl., Quesnelia indecora Mez, Tillandsia polystachia (L.) L., T. stricta Sol., T. gardneri Lindl., T. geminiflora Brongn. and Vriesea grandiflora Leme. Light and scanning electron microscopy were used and the species were grouped into three pollen types, organized according to aperture characteristics: Type I - pantoporate pollen grains observed in P. petropolitana, Type II - 2-porate pollen grains, observed in the genera Ananas, Aechmea and Quesnelia, and Type III - 1-colpate pollen grains, observed in the genera Billbergia, Pitcairnia, Tillandsia and Vriesea. Pollen data led to the construction of an identification key. The results showed that the species analyzed can be distinguished using mainly aperture features and exine ornamentation, and that these characteristics may assist in taxonomic studies of the family.
Capri, M. A. L.; Lemes, V. E. R.; Sobreiro, R. F.; Sorella, S. P.; Thibes, R.
We pursue the study of SU(2) Euclidean Yang-Mills theory in the maximal Abelian gauge by taking into account the effects of the Gribov horizon. The Gribov approximation, previously introduced in [M. A. L. Capri, V. E. R. Lemes, R. F. Sobreiro, S. P. Sorella, and R. Thibes, Phys. Rev. D 72, 085021 (2005).], is improved through the introduction of the horizon function, which is constructed under the requirements of localizability and renormalizability. By following Zwanziger’s treatment of the horizon function in the Landau gauge, we prove that, when cast in local form, the horizon term of the maximal Abelian gauge leads to a quantized theory which enjoys multiplicative renormalizability, a feature which is established to all orders by means of the algebraic renormalization. Furthermore, it turns out that the horizon term is compatible with the local residual U(1) Ward identity, typical of the maximal Abelian gauge, which is easily derived. As a consequence, the nonrenormalization theorem, ZgZA1/2=1, relating the renormalization factors of the gauge coupling constant Zg and of the diagonal gluon field ZA, still holds in the presence of the Gribov horizon. Finally, we notice that a generalized dimension two gluon operator can be also introduced. It is BRST invariant on-shell, a property which ensures its multiplicative renormalizability. Its anomalous dimension is not an independent parameter of the theory, being obtained from the renormalization factors of the gauge coupling constant and of the diagonal antighost field.
Oliveira, Carlos A. F.; Gonçalves, Natália B.; Rosim, Roice E.; Fernandes, Andrezza M.
The aim of the present study was to determine aflatoxin levels in peanut products traded in the Northeast region of São Paulo, Brazil. To this end, 240 samples of peanut products traded in the cities of Araras, Leme, Pirassununga and Porto Ferreira were collected from June 2006 to May 2007. The samples were analyzed for aflatoxins (AF) B1, B2, G1 and G2 by high performance liquid chromatography. Results showed 44.2% samples positive for AF at levels of 0.5 to 103.8 μg·kg−1. Nine of the positive samples (3.7% of the analysed samples) had total aflatoxin concentrations (B1+B2+G1+G2) higher than the limit established by Brazilian regulations (20 μg·kg−1). Based on the above data, the probable mean daily intake (PDIM) of aflatoxins from peanut products in the Northeast region of São Paulo was estimated to be 0.23 ng kg b.w. day−1. Although this PDIM value was relatively low, results indicate that aflatoxin contamination of peanut products may be a public health concern in Brazil, when considering the potential exposure of highly susceptible consumers. For example, it should be emphasized that children are potentially exposed to aflatoxins, since they consume large quantities of peanut candies, and these products had the highest number of samples positive for AFB1. PMID:19333440
Mudrić, Sanja Ž; Gašić, Uroš M; Dramićanin, Aleksandra M; Ćirić, Ivanka Ž; Milojković-Opsenica, Dušanka M; Popović-Đorđević, Jelena B; Momirović, Nebojša M; Tešić, Živoslav Lj
Spice peppers (Capsicum annuum L.) var. Lemeška and Lakošnička paprika were investigated to evaluate their polyphenolic and carbohydrate profiles and antioxidant activity. A total of forty-nine polyphenolics were identified using ultrahigh-performance liquid chromatography (UHPLC) coupled to LTQ OrbiTrap mass analyzer. Twenty-five of them were quantified using available standards, while the other compounds were confirmed by exact mass search of their deprotonated molecule [M-H](-) and its MS(4) fragmentation. Thirteen carbohydrates were quantified using high-performance anion exchange chromatography (HPAEC) with pulsed amperometric detection (PAD). Radical scavenging activity (RSA) ranged from 17.32 to 48.34mmol TE (Trolox equivalent)/kg DW (dry weight) and total phenolics content (TPC) was ranged between 7.03 and 14.92g GAE (gallic acid equivalents)/kg DW. To our best knowledge, five polyphenolic compounds were for the first time tentatively identified in paprika: 5-O-p-coumaroylquinic acid, luteolin 7-O-(2″-O-pentosyl-4″-O-hexosyl)hexoside, quercetin 3-O-(2″-O-hexosyl)rhamnoside, isorhamnetin 3-O-[6″-O-(5-hydroxyferuloyl)hexoside]-7-O-rhamnoside, and luteolin 7-O-[2″-O-(5'″-O-sinapoyl)pentosyl-6″-O-malonyl]hexoside.
The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload.
İdilman, İlkay S; Gümrük, Fatma; Haliloğlu, Mithat; Karçaaltıncaba, Muşturay
Amaç: Bu çalışmada, transfüzyon ilişkili demir birikimi bulunan hastalarda karaciğer, pankreas, dalak, vertebral kemik iliği ve böbrek korteksi R2* ve manyetik rezonans görüntüleme-proton dansite yağ oranı (MRG-PDYO) ölçümünün uygulanabilirliği ve bunlar arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmaya, karaciğer demir birikimi şüphesi ile kliniğimize gönderilmiş olan toplam 9 hasta (5 erkek, 4 kız) dahil edildi. Tüm hastalara T2* düzeltmeli ve spektral yağ modellemeli T1 bağımsız volumetrik multi-eko gradient-eko görüntüleme yapıldı. MRG incelemeleri 1.5 T MRG sistemi ile yapıldı. Bulgular: Tüm hastalarda karaciğerde demir birikimi mevcuttu. Dokuz hastanın beşinde (%56) ağır demir birikimi saptandı ve bu hastaların PDYO haritaları incelendiğinde 4 hastada (R2* değeri 671 Hz’den fazla olanlarda) karaciğerde yaygın yamasal artefaktlar olduğu saptandı. Bu artefaktlara rağmen MRG-PDYO ölçümü yapıldığında normalden çok yüksek MRG-PDYO değerleri belirlendi. Ortalama pankreas R2* ve ortalama pankreas MRG-PDYO arasında (p=0,003, r=0,860), karaciğer R2* and ortalama pankreas R2* arasında (p=0,021, r=0,747), karaciğer R2* ve renal korteks R2* arasında (p=0,020, r=0,750) ve ortalama pankreas R2* ve renal korteks R2* arasında (p=0,003, r=0,858) anlamlı korelasyon saptandı. Vertebral kemik iliği R2* ve yaş arasında anlamlı negatif korelasyon saptandı (p=0,018, r=-0,759). Sonuç: Karaciğerdeki yüksek demir birikimi özellikle de T2* değeri ilk eko zamanından daha kısa olduğunda PDYO hesaplamasını bozabilmektedir. Pankreastaki yağ birikimi pankreatik demir birikimine eşlik edebilmektedir. Karaciğer ve pankreas siderozisi birbiri ile ilişki göstermektedir. Böbrek korteksi ve pankreas siderozisi arasında da ilişki mevcuttur.
Freitas-Lemes, P.; Rodrigues, I.; Faúndez-Abans, M.; Dors, O.
This work is part of a series of case studies of Polar Ring Galaxies (PRGs) (see also Posters GAL-1: 163, GAL-2: 178). A PRG is formed by an early type host galaxy (e.g. lenticular or elliptical), surrounded by a ring of gas and stars orbiting approximately at the polar plane of the host galaxy. AM2217-490 is an interesting case of PRG in formation, with a still asymmetrical ring that surrounds the host galaxy. Apparently, this bluish structure (characteristic of the rings of PRGs), is not yet in equilibrium with the host galaxy. This study is based on spectra on the range 6250-7250 Å obtained with the CTIO 1.5 m telescope - Chile. From them, we measure a heliocentric radial velocity of 9152± 18 km/s. The value of the ionization parameter (log U = -3.5) is similar to that in interacting galaxies (Freitas-Lemes et al. 2013, submitted to MNRAS; and Krabbe et al. 2013, MNRAS Accepted), and lower than that of isolated ones. The electron density shows little variation along the major axis of the host galaxy, and a mean value typical of interacting galaxies. Diagnostic diagrams show that the nuclear region harbors an AGN, following a trend among polar ring galaxies. The low-resolution images of the SDSS show no tails or bridges connecting the galaxy to other objects, however, in a radius of 5 arcmin there are three other galaxies with similar speeds, featuring a group. A plausible hypothesis is that one of these galaxies may have interacted with AM2217-490, donating material to form the ring.
Before the First World War Lvov was under the Austrian occupation and this is why there is only a scarce evidence of patriotic commitment of the Polish physicians. Political activities were demonstrated through occasional speeches given at the national ceremonies or during their inauguration of an academic year. One of such ceremonies was the centenary of F. Chopin's birth when a patriotic oration, kept till the present day in the family collection, was made by a representative of the University, Forensic Medicine Professor, Włodzimierz Sieradzki. During the First World War, the battle of Lvov and the war with Bolsheviks, many young physicians or doctors' sons took part in the warfare, displayed bravery and were honored with medals, and many of them were killed. Within the period between the world wars the atmosphere of patriotism was still enthusiastic. Subsequent years are hard to judge as the only material to be used to that end was mainly memoirs issued only in the People's Republic of Poland and these were to a large extent abridge by censorship. This also applies to the period of the Soviet occupation after the outbreak of the Second World War. The memoirs that depicted an open animosity towards the representatives of the Soviet authorities remained as typescripts and only today they are published, for instance the Memoirs of Neurosurgery Professor, Aleksander Domaszewicz.
2006-01-01This artist's concept depicts the pulsar planet system discovered by Aleksander Wolszczan in 1992. Wolszczan used the Arecibo radio telescope in Puerto Rico to find three planets - the first of any kind ever found outside our solar system - circling a pulsar called PSR B1257+12. Pulsars are rapidly rotating neutron stars, which are the collapsed cores of exploded massive stars. They spin and pulse with radiation, much like a lighthouse beacon. Here, the pulsar's twisted magnetic fields are highlighted by the blue glow. All three pulsar planets are shown in this picture; the farthest two from the pulsar (closest in this view) are about the size of Earth. Radiation from charged pulsar particles would probably rain down on the planets, causing their night skies to light up with auroras similar to our Northern Lights. One such aurora is illustrated on the planet at the bottom of the picture. Since this landmark discovery, more than 160 extrasolar planets have been observed around stars that are burning nuclear fuel. The planets spotted by Wolszczan are still the only ones around a dead star. They also might be part of a second generation of planets, the first having been destroyed when their star blew up. The Spitzer Space Telescope's discovery of a dusty disk around a pulsar might represent the beginnings of a similarly 'reborn' planetary system.
A review written by professor Leon Popielski from Lvov of the qualifying thesis for professorship of January Zubrzycki from Cracow is presented. The manuscript has been kept by professor Popielski's family. Zubrzycki finished his medical studies in Cracow in 1909. While writing his qualifying thesis entitled Placental Albumin Derivatives and their Toxic Properties in 1915 he was an assistant of Aleksander Rosner in the department of maternity and gynaecology of Jagiellonian University. In 1931 as a professor he became the head of the clinic and following the Second World War he was a professor at several faculties of medicine in Poland. He was an outstanding gynaecological surgeon, an author of a five volume atlas of gynaecological surgery. Professor Leon Popielski studied in S. Petersburg. He specialized in physiology. Since 1904 he was the head of the Chair of Pharmacologoy and Pharmacognosy at the Universitiy of Lvov. Popielski's intrest in Zubrzycki's work ensued his research on albumin metabolite effect. His appreciation of the work is expressed by the phrase "I read it with satisfaction". The review was written in 1919, belated by the war.
a high standing scientific programme. Finally, we thank the Royal Swedish Academy of Sciences through its Nobel Committee for Physics, the Royal Physiographical Society in Lund, the Technical Faculty (LTH) at Lund University, and the Swedish Research Council (VR) for financial support. Sven Aberg, Ragnar Bengtsson, Ingemar Ragnarsson and Stephanie Reimann Department of Mathematical Physics, Lund Institute of Technology, S-22100 Lund, Sweden Joakim Cederkäll, Claes Fahlander and Dirk Rudolph Division of Nuclear Physics, Lund University, S-22100 Lund, Sweden
Overstreet, David H; Wegener, Gregers
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal paper, and there has been a steady stream of publications (130+) over the years. The present review will focus on several issues not previously covered in earlier reviews, summarize the several lines of ongoing investigations, and propose a novel mechanism that accounts for a number of previously unexplained observations. A key observation in the FSL rat relates to the antidepressant (AD)-like effects of known and putative antidepressants. The FSL rat typically exhibits an AD-like effect in behavioral tests for AD-like activity following chronic (14 days) treatment, although some studies have found AD-like effects after fewer days of treatment. In other observations, exaggerated swim test immobility in the FSL rat has been found to have a maternal influence, as shown by cross-fostering studies and observations of maternal behavior; the implications of this finding are still to be determined. Ongoing or recently completed studies have been performed in the laboratories of Marko Diksic of Canada, Aleksander Mathé of Sweden, Gregers Wegener of Denmark, Brian Harvey of South Africa, Paul Pilowsky and Rod Irvine of Australia, and Gal Yadid of Israel. Jennifer Loftis of Portland, Oregon, and Lynette Daws of San Antonio, Texas, have been working with the FSL rats in the United States. A puzzling feature of the FSL rat is its sensitivity to multiple chemicals, and its greater sensitivity to a variety of drugs with different mechanisms of action. It has been recently shown that each of these drugs feeds through G protein-coupled receptors to potassium-gated channels. Thus, an abnormality in the potassium channel could underlie the depressed-like behavior of the FSL rats.
The paper deals with the issue of Polish intelligentsia in the inter-war period (1918-1939). In the introduction, the author presents various approaches that can be adopted in investigating this problem, approaches that focus on the analysis of the social awareness of that social stratum and on its transformations form the perspective of social structure. Further on in the paper, the author points to the image of Polish intelligentsia of that period as it emerges from an analysis of the feature writing of the period, i.e. to the image of the intelligentsia's self-awareness, and to the image that is revealed in the writings of historians of the inter-war period. Finally, in the main section of the paper, the author presents the views of four sociologists who lived and worked in the interwar period who dealt with the issue of the Polish intelligentsia: Florian Znaniecki (1882-1958), Aleksander Hertz (1895-1983), Stanisław Rychliński (1903-1944) and Józef Chałasiński (1904-1979). The views of those sociologists are juxtaposed with opinions of journalists and historians, to see how valuable and original such views were. Their views on the intelligentsia are also analysed against the background of the developments in sociology of that period, of the areas or interest of the sociologists involved, and of the theoretical frameworks which they followed. The sociologists' research on the intelligentsia can be seen as part of a wider range of studies on transformations in culture (Znaniecki, Hertz) and social structure (Rychliński, Chałasiński). All four sociologists pointed to the changes that the Polish intelligentsia was subject to and to the problems involved in implementing its leadership role. Apart from Chałasiński, the sociologists appreciated the positive role of the intelligentsia in Polish society and indicated the need to take measures aimed at reconstructing the paths of advancement into the social elite, a great role in which was attributed to
Goryawala, Mohammed; Adjoua, Malek; Güleç, Seza
Amaç: In vivo aktif Kemik İliği’nin (Kİ) kantitatif değerlendirmesi tam olarak tanımlanmış değildir. Bu çalışmadaki amaç 18F-FLT ve 18F FDG görüntüleme yöntemleriyle kemik iliğinin hücresel bölünme aktivitesi ile glikolitik aktivite ile tanımlanan hacimlerinin mukayesesini yapmaktır. Bu spesifik çalışmaya esas olan ana çalışma, pancreas kanserli hastalarda başlatılmış bir faz 1 araştırmasıdır. Yöntem: By faz 1 çalışmaya pancreas kanseri olan yedi hasta dahil edilmiştir, bir hafta içerisinde hem 18F-FLT hem 18F-FDG görüntülemesi yapılmış, kemik dokusunu kortikal ve trabeküler bölgelere ayırmak için BT bazlı bir sınıflama kullanılmıştır. Total Kİ hacmi, trabeküler kemikteki PET aktivitesinin istatiki bir eşikleme metodu uygulanarak belirlenmiştir. Bulgular: 18F-FLT ile elde edilen kırmızı Kİ hacmi (KKİ) 18F-FDG ile saptanadan daha yüksek bulunmuştur (∆=89,21 ml). 18F-FLT ile saptanan KKİ erkeklerde ağırlık (R2=0,61) ve KKİ (R2=0,70) ile yüksek korelasyon göstermektedir. 18F-FLT ile elde edilen kırmızı Kİ fraksiyonu erkekler ve kadınlar arasında anlamlı farklılık göstermekteydi, kadınlarda trabeküler kemik içerisinde daha yüksek kırmızı kemik maddesi bulunmaktaydı (p<0,05). 18F-FLT’nin aksine 18F-FDG Kİ ölçümleri KKİ’nin kadınlar ve erkekler arsında anlamlı farklılık gösterdiği saptandı (p<0,05). Sonuçlar kırmızı Kİ segmentasyonu için spinal aktivite SUV eşiğinin 18F-FLT PET ile 18F-FDG PET arasında anlamlı derecede farklı olduğunu gösterdi (p<0,05). Sonuç: Bu çalışma 18F-FLT-PET ile 18F-FDG-PET’in birleştirilmesinin proliferative ve glikolitik aktivitelerine bağlı olarak in vivo Kİ tahminine önemli katkı sağladığını göstermektedir.
Sürer Budak, Evrim; Toptaş, Tayfun; Aydın, Funda; Öner, Ali Ozan; Çevikol, Can; Şimşek, Tayup
Amaç: Endometrium kanserinde (EK) primer tümörün maksimum standardize tutulum değeri (SUVmaks) ve minimum görünen difüzyon katsayısının (ADCmin) klinikopatolojik özellikler ile olan ilişkisini araştırmak ve bunların öngörü gücünü belirlemektir. Yöntem: 18F-fluorodeoksiglukoz (FDG) pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) ve difüzyon ağırlıklı-manyetik rezonans görüntüleme (DA-MRG) ile preoperatif değerlendirmeyi takiben evreleme cerrahisi yapılan toplamda 45 hasta, planlı veri toplama yapılan prospektif bir olgu serisine dahil edildiler. Çalışma verileri arasındaki ilişkiler çoklu doğrusal regresyon analizi ile araştırıldı. Bulgular: Ortalama ADCmin ve SUVmaks sırasıyla 0,72±0,22 ve 16,54±8,73 olarak bulundu. Tek değişkenli analizde yaş, myometriyal invazyon (Mİ) ve lenfovasküler alan tutulumu (LVAT) ADCmin ile ilişkili potansiyel faktörler olarak bulunurken, yaş, evre, tümör büyüklüğü, LVAT ve metastatik lenf düğümlerinin sayısı SUVmaks ile ilişkili potansiyel değişkenler olarak tespit edildiler. Diğer taraftan, çok değişkenli analizde Mİ, ADCmin (p=0,007) ve SUVmaks (p=0,024) ile ilişkili tek anlamlı değişkendi. Derin Mİ en iyi, ≤0,77’lik [%93,7 duyarlılık, %48,2 özgüllük ve %93,0 negatif öngörü değeri (NPD)] bir ADCmin kesim değeri ve >20,5’lik (%62,5 duyarlılık, %86,2 özgüllük ve %81,0 NPD) bir SUVmaks kesim değeri ile öngörülebiliyordu. Ne var ki, her iki tanısal test birbirlerinden anlamlı şekilde farklı değildi (p=0,266). Sonuç: Klinikopatolojik özelliklerden yalnızca Mİ bağımsız ve anlamlı şekilde SUVmaks ve ADCmin ile ilişkiliydi. Ne var ki, her iki parametrenin ideal olmayan öngörü performansları nedeniyle 18F-FDG PET/BT veya DA-MRG’nin rutin kullanımı şu noktada önerilemez.
Terzi, Yunus Kasım; Bulakbaşı Balcı, Tuğçe; Boğa, Can; Koç, Zafer; Yılmaz Çelik, Zerrin; Özdoğu, Hakan; Karakuş, Sema; Şahin, Feride İffet
Amaç: Hemokromatozis, demir birikiminin önemli nedenlerinden biri olan otozomal resesif bir hastalıktır. Orak hücreli anemi, hemoglobin genindeki homozigot mutasyon sonucu ortaya çıkan bir hemoglobinopatidir. Eritrosit transfüzyonu, bu hastalığın tedavisinde sıklıkla kullanılmaktadır. Transfüzyonun yarattığı demir yükü diğer hemoglobinopatilerde olduğu gibi orak hücreli anemi hastalarının mortalite ve morbiditesinde önem kazanmaktadır. Bu çalışmada hemokromatozis geni (HFE) p.H63D ve p.C282Y mutasyonlarının, homozigot hemoglobin S mutasyonu taşıyan orak hücreli anemi hastalarında, kalp ve karaciğerde transfüzyonla ilişkili demir yüklenmesine olan etkisi araştırılmıştır. Gereç ve Yöntemler: Bu çalışma, homozigot hemoglobin S mutasyonu olan hastalarda 2008-2013 yıllarını kapsayan prospektif, tek merkezli kesitsel bir çalışmadır. Hastalar şelasyon tedavisi alan (n=31) ve almayan (n=13) olarak iki gruba ayrıldı. Hastalarda direk ve endirekt demir yükü sırasıyla manyetik rezonans görüntüleme ve biyokimyasal olarak analiz edildi. HFE geni mutasyon analizi polimeraz zincir reaksiyonu-restriksiyon fragment uzunluk polimorfizmi yöntemleri ile gerçekleştirildi. İstatistik analizi Independent samples t-testi uygulanarak gerçekleştirildi. Bulgular: p.H63D mutasyonu grup A’da 10 hastada (%32,3), grup B’de ise sadece 1 (%7,7) hastada saptandı. Demir birikimi açısından gruplar karşılaştırıldığında karaciğerde demir birikiminin grup B’de istatistiksel olarak anlamlı derecede yüksek olduğu görülmüştür (p<0,05). Grup A’da, mutasyonu olan bireylerde olmayanlara göre karaciğerdeki demir birikiminin istatistiksel olarak anlamlı derecede yüksek olduğu görülmüştür (p=0,05). Sonuç: Bu çalışmanın sonucu HFE genindeki mutasyonların, orak hücreli anemi hastalarında karaciğerde demir birikimi üzerinde etkili olduğunu göstermektedir.
Bertemes Filho, Pedro
. In making this conference possible, we want to acknowledge our deep appreciation for the financial support of FAPESC (Foundation for Research and Innovation of Santa Catarina), CAPES (Coordination for the Improvement of Higher Level -or Education- Personnel) and also express our sincere thanks to the many individuals who contributed their time and diligence to making this conference possible. Our special thanks go to the Santa Catarina State University for contributing time and effort to organizing the conference. We also wish to express our thanks to Professors Ana Watanabe and Fabricio Noveletto for helping with the registration process, the conference desk and the diverse and sundry details that are the part of any event of this kind. We would like also to thank all of the invited speakers and the members of the Program Committee, and wopuld like to express our gratitude to the Technological Institute of Joinville (FITEJ) for their technical co-sponsorship. We very much appreciate Orjan Martinsen, Uwe Pliquett, Fernando Martinez Seoane, Raul Gonzalez Lima, Marcio Nogueira de Souza and Carlos Augusto Gonzalez Correa for delivering keynote talks at the conference. And we would like to extend an enthusiastic round of thanks to all of our conference authors for their excellent contributions; to all the session chairs for their effort and enthusiasm; and to all the International Program Committee members and referees for their time and expertise in the paper review. Particular thanks go to Emiliano Amarante Veiga and other members of the CLABIO2012 Secretariat and organizing team for their time and outstanding work. List of committees General Chair Professor Pedro Bertemes Filho (Santa Catarina State University) Pedro Bertemes Filho Technical Program Chairs Dr Marcio Nogueira de Souza (Rio de Janeiro Federal University) Local Arrangement Chair Professor Aleksander Paterno (Santa Catarina State University) Professor Fabrício Noveletto (Santa Catarina State University
atmospheric section to investigate the changes in the physical parameters of the ionosphere. Bill Gordon, in 1966, moved to Rice University in Houston, Texas, where he was a Distinguished Professor and Senior Administrator (Dean, Provost and Vice President). The Arecibo Ionospheric Observatory in 1970 was designated as 'The National Astronomy and Ionosphere Center' (NAIC), and began to be funded as a National Center by the National Science Foundation. Cornell has remained the managing institution since that time. Early in the 1970s a grant from the NSF made it possible to replace the surface of the telescope with perforated rigid panels allowing it to operate at least up to 5000 MHz. In the 1990s the long imperfect line feeds were replaced by a complex Gregorian system that greatly increased the sensitivity of the telescope. This allowed the radiation to be collected at a focal point rather than via a long line. These and other major improvements have kept the telescope as the most sensitive radio/radar telescope in the world. Observations of pulsars at Arecibo resulted in the 1993 Nobel Prize in Physics to Joseph Taylor and Russell Hulse who indirectly showed that gravitational waves exist, as Albert Einstein's general theory of relativity predicts. In 1990 Aleksander Wolszczan discovered a special pulsar and he was able to show that it was surrounded by earth size planets. The exotic and photogenic giant radar/radio telescope has also been featured in prominent movies such as the James Bond 'Golden Eye' in 1995, and Carl Sagan's 'Contact' in 1997. Bill's many graduate students from Cornell and Rice, simply adored him. One of his students, Dr. Richard A. Behnke, has said 'Simply he was the greatest man I have known'. Bill was married to Elva Freile Gordon for 61 years. Elva died in 2001. Bill later remarried with Elizabeth Bolgiano Gordon. In his career Bill received many awards. He was a member of the National Academy of Sciences and the National Academy of Engineering, and