Enhancing Power System Operational Flexibility With Flexible Ramping Products: A Review

DOE PAGES

Wang, Qin; Hodge, Bri-Mathias

2016-12-09

With the increased variability and uncertainty of net load induced from high penetrations of renewable energy resources and more flexible interchange schedules, power systems are facing great operational challenges in maintaining balance. Among these, the scarcity of ramp capability is an important culprit of power balance violations and high scarcity prices. To address this issue, market-based flexible ramping products (FRPs) have been proposed in the industry to improve the availability of ramp capacity. This paper presents an in-depth review of the modeling and implementation of FRPs. The major motivation is that although FRPs are widely discussed in the literature, itmore » is still unclear to many how they can be incorporated into a co-optimization framework that includes energy and ancillary services. The concept and a definition of power system operational flexibility as well as the needs for FRPs are introduced. The industrial practices of implementing FRPs under different market structures are presented. Market operation issues and future research topics are also discussed. In conclusion, this paper can provide researchers and power engineers with further insights into the state of the art, technical barriers, and potential directions for FRPs.« less

Supersonic investigation of two dimensional hypersonic exhaust nozzles

NASA Technical Reports Server (NTRS)

Carboni, Jeanne D.; Shyne, Rickey J.; Leavitt, Laurence D.; Taylor, John G.; Lamb, Milton

1992-01-01

An experimental investigation was conducted in the NASA Lewis 10 x 10 ft supersonic Wind Tunnel to determine the performance characteristics of 2D hypersonic exhaust nozzles/afterbodies at low supersonic conditions. Generally, this type of application requires a single expansion ramp nozzle (SERN) that is highly integrated with the airframe of the hypersonic vehicle. At design conditions (hypersonic speeds), the nozzle generally exhibits acceptable performance. At off-design conditions (transonic to mid-supersonic speeds), nozzle performance of a fixed geometry configuration is generally poor. Various 2-D nozzle configurations were tested at off-design conditions from Mach 2.0 to 3.5. Performance data is presented at nozzle pressure ratios from 1 to 35. Jet exhaust was simulated with high-pressure air. To study performance of different geometries, nozzle configurations were varied by interchanging the following model parts: internal upstream contour, expansion ramp, sidewalls, and cowl.

Ring current impoundment of the Io plasma torus

NASA Technical Reports Server (NTRS)

Siscoe, G. L.; Thorne, R. M.; Richardson, J. D.; Bagenal, F.; Sullivan, J. D.; Eviatar, A.

1981-01-01

A newly discovered feature in the Io plasma formation that may be described as a ramp separating a high-density plasma ledge on its Jupiterward side from the lower-density radially distended Io plasma disc on its anti-Jupiterward side is observed to coincide with a marked inward decrease in the ring current population. The spatial congruency of the counter-directed maximal gradients in both plasma bodies reveals a profound coupling between them. The existence of the ramp requires a local order-of-magnitude reduction in the diffusion coefficient that governs radial mass transport. It is demonstrated that the diminished diffusive efficiency there is caused by strong pressure gradient inhibition of the interchange instability that underlies mass transport. The Io plasma torus, which is defined as the region of strong ultraviolet emissions, is identified as the plasma ledge. The plasma density in the ledge is high and, incidentally therefore, able to emit strongly because it is impounded against rapid, centrifugal expulsion by the inwardly directed pressure of the ring current at its inner edge.

Exercise Thresholds on Trial: Are They Really Equivalent?

PubMed

Caen, Kevin; Vermeire, Kobe; Bourgois, Jan G; Boone, Jan

2018-06-01

The interchangeable use of whole-body exercise thresholds and breakpoints (BP) in the local oxygenation response, as measured via near-infrared spectroscopy, has recently been questioned in scientific literature. Therefore, the present study aimed to longitudinally investigate the interrelationship of four commonly used exercise thresholds: critical power (CP), the respiratory compensation point (RCP), and BP in muscle (m[HHb]BP) and brain (c[O2Hb]BP) oxygenation. Nine male participants (21.8 ± 1.2 yr) completed 6 wk of cycling interval training. Before and after this intervention period, subjects performed a ramp incremental exercise protocol to determine RCP, m[HHb]BP, and c[O2Hb]BP and four constant work rate (WR) tests to calculate CP. WR associated with CP, RCP, m[HHB]BP, and c[O2Hb]BP increased by 7.7% ± 4.2%, 13.6% ± 9.0%, 9.8% ± 5.7%, and 11.3% ± 11.1%, respectively. CP was lower (pre: 260 ± 32 W, post: 280 ± 41 W; P < 0.05) than the WR associated with RCP (pre: 281 ± 28 W, post: 318 ± 36 W) and c[O2Hb]BP (pre: 283 ± 36 W, post: 313 ± 32 W) which occurred concomitantly (P = 0.683). M[HHb]BP occurred at the highest WR and differed from all others (pre: 313 ± 23 W, post: 344 ± 32 W; P < 0.05). Training-induced WR differences (ΔWR) did not contrast between thresholds, and initial parameter differences were not affected by the intervention (P = 0.253). Thresholds were partly correlated before (R = 0.67-0.85, P < 0.05) and after (R = 0.83-0.96, P < 0.05) training, but ΔWR values were not associated (P > 0.05). Results of the present study strongly question true equivalence of CP, RCP, m[HHb]BP, and c[O2Hb]BP during ramp incremental exercise. Therefore, these exercise thresholds should not be used interchangeably.

Sawtooth oscillations in shaped plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lazarus, E. A.; Luce, T. C.; Burrell, K. H.

The role of interchange and internal kink modes in the sawtooth oscillations is explored by comparing bean- and oval-shaped plasmas. The n=1 instability that results in the collapse of the sawtooth has been identified as a quasi-interchange in the oval cases and the internal kink in the bean shape. The ion and electron temperature profiles are followed in detail through the sawtooth ramp. It is found that electron energy transport rates are very high in the oval and quite low in the bean shape. Ion energy confinement in the oval is excellent and the sawtooth amplitude ({delta}T/T) in the ionmore » temperature is much larger than that of the electrons. The sawtooth amplitudes for ions and electrons are comparable in the bean shape. The measured q profiles in the bean and oval shapes are found to be consistent with neoclassical current diffusion of the toroidal current, and the observed differences in q largely result from the severe differences in electron energy transport. For both shapes the collapse flattens the q profile and after the collapse return to q{sub 0} > or approx. 1. Recent results on intermediate shapes are reported. These shapes show that the electron energy transport improves gradually as the plasma triangularity is increased.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pennock, Kenneth; Makarov, Yuri V.; Rajagopal, Sankaran

The need for proactive closed-loop integration of uncertainty information into system operations and probability-based controls is widely recognized, but rarely implemented in system operations. Proactive integration for this project means that the information concerning expected uncertainty ranges for net load and balancing requirements, including required balancing capacity, ramping and ramp duration characteristics, will be fed back into the generation commitment and dispatch algorithms to modify their performance so that potential shortages of these characteristics can be prevented. This basic, yet important, premise is the motivating factor for this project. The achieved project goal is to demonstrate the benefit of suchmore » a system. The project quantifies future uncertainties, predicts additional system balancing needs including the prediction intervals for capacity and ramping requirements of future dispatch intervals, evaluates the impacts of uncertainties on transmission including the risk of overloads and voltage problems, and explores opportunities for intra-hour generation adjustments helping to provide more flexibility for system operators. The resulting benefits culminate in more reliable grid operation in the face of increased system uncertainty and variability caused by solar power. The project identifies that solar power does not require special separate penetration level restrictions or penalization for its intermittency. Ultimately, the collective consideration of all sources of intermittency distributed over a wide area unified with the comprehensive evaluation of various elements of balancing process, i.e. capacity, ramping, and energy requirements, help system operators more robustly and effectively balance generation against load and interchange. This project showed that doing so can facilitate more solar and other renewable resources on the grid without compromising reliability and control performance. Efforts during the project included developing and integrating advanced probabilistic solar forecasts, including distributed PV forecasts, into closed –loop decision making processes. Additionally, new uncertainty quantifications methods and tools for the direct integration of uncertainty and variability information into grid operations at the transmission and distribution levels were developed and tested. During Phase 1, project work focused heavily on the design, development and demonstration of a set of processes and tools that could reliably and efficiently incorporate solar power into California’s grid operations. In Phase 2, connectivity between the ramping analysis tools and market applications software were completed, multiple dispatch scenarios demonstrated a successful reduction of overall uncertainty and an analysis to quantify increases in system operator reliability, and the transmission and distribution system uncertainty prediction tool was introduced to system operation engineers in a live webinar. The project met its goals, the experiments prove the advancements to methods and tools, when working together, are beneficial to not only the California Independent System Operator, but the benefits are transferable to other system operators in the United States.« less

ROADMs for reconfigurable metro networks

NASA Astrophysics Data System (ADS)

Homa, Jonathan; Bala, Krishna

2009-01-01

Reconfigurable Optical Add-Drop Multiplexers (ROADMs) are the key nodal sub-systems that are used to implement modern DWDM networks. They provide network flexibility by switching wavelengths among fibers under software control without expensive conversion to the electronic domain. They speed up provisioning time, reduce operational costs and eliminate human errors. Two general types of ROADMs are used in Metro optical networks, two-degree and multi-degree, where the degree refers to the numbers of DWDM fibers entering and exiting the ROADM node. A twodegree ROADM is like a location on a highway with off and on ramps to drop off and accept local traffic while a multidegree ROADM is like an interchange where highways meet and is used for interconnecting DWDM rings or for mesh networking. The paper describes two-degree and multi-degree ROADM architectures and how these relate to the technology alternatives used to implement the ROADMs themselves. Focus is provided on the role and expected evolution of the wavelength selective switch (WSS) which is the primary engine used to power ROADMs.

NASA's Exploration Technology Development Program Energy Storage Project Battery Technology Development

NASA Technical Reports Server (NTRS)

Reid, Concha M.; Miller, Thomas B.; Mercer, Carolyn R.; Jankovsky, Amy L.

2010-01-01

Technical Interchange Meeting was held at Saft America s Research and Development facility in Cockeysville, Maryland on Sept 28th-29th, 2010. The meeting was attended by Saft, contractors who are developing battery component materials under contracts awarded through a NASA Research Announcement (NRA), and NASA. This briefing presents an overview of the components being developed by the contractor attendees for the NASA s High Energy (HE) and Ultra High Energy (UHE) cells. The transition of the advanced lithium-ion cell development project at NASA from the Exploration Technology Development Program Energy Storage Project to the Enabling Technology Development and Demonstration High Efficiency Space Power Systems Project, changes to deliverable hardware and schedule due to a reduced budget, and our roadmap to develop cells and provide periodic off-ramps for cell technology for demonstrations are discussed. This meeting gave the materials and cell developers the opportunity to discuss the intricacies of their materials and determine strategies to address any particulars of the technology.

Analysis Methodology for Balancing Authority Cooperation in High Penetration of Variable Generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarov, Yuri V.; Etingov, Pavel V.; Zhou, Ning

2010-02-01

With the rapidly growing penetration level of wind and solar generation, the challenges of managing variability and the uncertainty of intermittent renewable generation become more and more significant. The problem of power variability and uncertainty gets exacerbated when each balancing authority (BA) works locally and separately to balance its own subsystem. The virtual BA concept means various forms of collaboration between individual BAs must manage power variability and uncertainty. The virtual BA will have a wide area control capability in managing its operational balancing requirements in different time frames. This coordination results in the improvement of efficiency and reliability ofmore » power system operation while facilitating the high level integration of green, intermittent energy resources. Several strategies for virtual BA implementation, such as ACE diversity interchange (ADI), wind only BA, BA consolidation, dynamic scheduling, regulation and load following sharing, extreme event impact study are discussed in this report. The objective of such strategies is to allow individual BAs within a large power grid to help each other deal with power variability. Innovative methods have been developed to simulate the balancing operation of BAs. These methods evaluate the BA operation through a number of metrics — such as capacity, ramp rate, ramp duration, energy and cycling requirements — to evaluate the performances of different virtual BA strategies. The report builds a systematic framework for evaluating BA consolidation and coordination. Results for case studies show that significant economic and reliability benefits can be gained. The merits and limitation of each virtual BA strategy are investigated. The report provides guidelines for the power industry to evaluate the coordination or consolidation method. The application of the developed strategies in cooperation with several regional BAs is in progress for several off-spring projects.« less

Integration of Variable Speed Pumped Hydro Storage in Automatic Generation Control Systems

NASA Astrophysics Data System (ADS)

Fulgêncio, N.; Moreira, C.; Silva, B.

2017-04-01

Pumped storage power (PSP) plants are expected to be an important player in modern electrical power systems when dealing with increasing shares of new renewable energies (NRE) such as solar or wind power. The massive penetration of NRE and consequent replacement of conventional synchronous units will significantly affect the controllability of the system. In order to evaluate the capability of variable speed PSP plants participation in the frequency restoration reserve (FRR) provision, taking into account the expected performance in terms of improved ramp response capability, a comparison with conventional hydro units is presented. In order to address this issue, a three area test network was considered, as well as the corresponding automatic generation control (AGC) systems, being responsible for re-dispatching the generation units to re-establish power interchange between areas as well as the system nominal frequency. The main issue under analysis in this paper is related to the benefits of the fast response of variable speed PSP with respect to its capability of providing fast power balancing in a control area.

Lectotype designation for Murex nebula Montagu 1803 (Mangeliidae) and its implications for Bela Leach in Gray 1847.

PubMed

Daniele, Scarponi; Landau, Bernard; Janssen, Ronald; Morgenroth, Holly; Bella, Giano Della

2014-11-12

Bela Leach in Gray is a misapplied and broadly defined genus within the family Mangeliidae Fischer, 1883. Examination of material from the Montagu collection at the Royal Albert Memorial Museum & Art Gallery (RAMM) in Exeter (UK) led to the discovery of six specimens of Murex nebula Montagu 1803 (the type species of Bela). This material is considered to belong to the original lot used by Montagu to define his species. We selected the best-preserved specimen as a lectotype. The lectotype and paralectotypes deposited at the RAMM are fully described and illustrated. Furthermore, diagnostic characters for recognizing B. nebula specimens are presented: protoconch shows weak ornamentation; teleoconch is fusiform with slightly convex whorls characterized by broad, suture-to-suture ribs and dense but weak spiral elements; outer lip is thin; anal sinus is shallow, placed on the shoulder ramp. These key features are of basic importance for: i) restricting the usage of the genus Bela and promoting its stability and consistent usage in literature and ii) separating two allied (and sometimes interchanged) genera: Bela and Mangelia Risso 1826.

Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs).

PubMed

Fischer, J A; Muff, R; Born, W

2002-08-01

The calcitonin (CT) receptor (CTR) and the CTR-like receptor (CRLR) are close relatives within the type II family of G-protein-coupled receptors, demonstrating sequence identity of 50%. Unlike the interaction between CT and CTR, receptors for the related hormones and neuropeptides amylin, CT-gene-related peptide (CGRP) and adrenomedullin (AM) require one of three accessory receptor-activity-modifying proteins (RAMPs) for ligand recognition. An amylin/CGRP receptor is revealed when CTR is co-expressed with RAMP1. When complexed with RAMP3, CTR interacts with amylin alone. CRLR, initially classed as an orphan receptor, is a CGRP receptor when co-expressed with RAMP1. The same receptor is specific for AM in the presence of RAMP2. Together with human RAMP3, CRLR defines an AM receptor, and with mouse RAMP3 it is a low-affinity CGRP/AM receptor. CTR-RAMP1, antagonized preferentially by salmon CT-(8-32) and not by CGRP-(8-37), and CRLR-RAMP1, antagonized by CGRP-(8-37), are two CGRP receptor isotypes. Thus amylin and CGRP interact specifically with heterodimeric complexes between CTR and RAMP1 or RAMP3, and CGRP and AM interact with complexes between CRLR and RAMP1, RAMP2 or RAMP3.

Vortex Generators to Control Boundary Layer Interactions

NASA Technical Reports Server (NTRS)

Babinsky, Holger (Inventor); Loth, Eric (Inventor); Lee, Sang (Inventor)

2014-01-01

Devices for generating streamwise vorticity in a boundary includes various forms of vortex generators. One form of a split-ramp vortex generator includes a first ramp element and a second ramp element with front ends and back ends, ramp surfaces extending between the front ends and the back ends, and vertical surfaces extending between the front ends and the back ends adjacent the ramp surfaces. A flow channel is between the first ramp element and the second ramp element. The back ends of the ramp elements have a height greater than a height of the front ends, and the front ends of the ramp elements have a width greater than a width of the back ends.

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology

PubMed Central

Watkins, H A; Walker, C S; Ly, K N; Bailey, R J; Barwell, J; Poyner, D R; Hay, D L

2014-01-01

Background and Purpose Receptor activity-modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor-like receptor (CLR). The interactions of the different RAMPs with this class B GPCR yield high-affinity calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors. However, the mechanism for this is unclear. Experimental Approach Guided by receptor models, we mutated residues in the N-terminal helix of CLR, RAMP2 and RAMP3 hypothesized to be involved in peptide interactions. These were assayed for cAMP production with AM, AM2 and CGRP together with their cell surface expression. Binding studies were also conducted for selected mutants. Key Results An important domain for peptide interactions on CLR from I32 to I52 was defined. Although I41 was universally important for binding and receptor function, the role of other residues depended on both ligand and RAMP. Peptide binding to CLR/RAMP3 involved a more restricted range of residues than that to CLR/RAMP1 or CLR/RAMP2. E101 of RAMP2 had a major role in AM interactions, and F111/W84 of RAMP2/3 was important with each peptide. Conclusions and Implications RAMP-dependent effects of CLR mutations suggest that the different RAMPs control accessibility of peptides to binding residues situated on the CLR N-terminus. RAMP3 appears to alter the role of specific residues at the CLR-RAMP interface compared with RAMP1 and RAMP2. PMID:24199627

Evaluation of a fuzzy logic ramp metering algorithm : a comparative study among three ramp metering algorithms used in the greater Seattle area

DOT National Transportation Integrated Search

2000-02-01

A Fuzzy Logic Ramp Metering Algorithm was implemented on 126 ramps in the greater Seattle area. Two multiple-ramp study sites were evaluted by comparing the fuzzy logic controller (FLC) to the other two ramp metering algorithms in operation at those ...

Understanding Micro-Ramp Control for Shock Boundary Layer Interactions

DTIC Science & Technology

2008-02-07

micro-ramps on a supersonic boundary layer at M=3.0 was investigated using monotone integrated Large Eddy Simulations (MILES) and Reynolds Averaged Navier... Supersonic boundary layer flow with micro-ramp and no shock wave 3.2 SBLI with no micro-ramp 3.3 SBLI with micro-ramp 3.4 Micro-ramp size and location IV . C...ramps on a supersonic boundary layer at M=3.0 was investigated using monotone integrated Large Eddy Simulations (MILES) and Reynolds Averaged Navier

Guidelines for preliminary selection of the optimum interchange type for a specific location

DOT National Transportation Integrated Search

1999-01-01

In Virginia, when new construction or major reconstruction is planned, the current practice is for a location and design engineer to select the interchange type (diamond interchange, single-point urban interchange, trumpet interchange, full cloverlea...

Performance of alternative diamond interchange forms : Volume II--guidelines for selecting alternative diamond interchanges.

DOT National Transportation Integrated Search

2017-01-01

Service interchanges connect freeways to arterial roads and are the backbone of the U.S. road network. Improving the operations of service interchanges is possible by applying one of several new solutions: diverging diamond, single point interchanges...

Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors.

PubMed

Qi, Tao; Ly, Kien; Poyner, David R; Christopoulos, George; Sexton, Patrick M; Hay, Debbie L

2011-05-01

The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). The CGRP receptor is a CLR/RAMP1 pairing whereas CLR/RAMP2 and CLR/RAMP3 constitute two subtypes of AM receptor: AM(1) and AM(2), respectively. Previous studies identified Glu74 in RAMP3 to be important for AM binding and potency. To further understand the importance of this residue and its equivalent in RAMP1 (Trp74) we substituted the native amino acids with several others. In RAMP3, these were Trp, Phe, Tyr, Ala, Ser, Thr, Arg and Asn; in RAMP1, Glu, Phe, Tyr, Ala and Asn substitutions were made. The mutant RAMPs were co-expressed with CLR in Cos7 cells; receptor function in response to AM, AM(2)/intermedin and CGRP was measured in a cAMP assay and cell surface expression was determined by ELISA. Phe reduced AM potency in RAMP3 but had no effect in RAMP1. In contrast, Tyr had no effect in RAMP3 but enhanced AM potency in RAMP1. Most other substitutions had a small effect on AM potency in both receptors whereas there was little impact on CGRP or AM(2) potency. Overall, these data suggest that the geometry and charge of the residue at position 74 contribute to how AM interacts with the AM(2) and CGRP receptors and confirms the role of this position in dictating differential AM pharmacology at the AM(2) and CGRP receptors. Copyright © 2011. Published by Elsevier Inc.

Wind Energy Management System EMS Integration Project: Incorporating Wind Generation and Load Forecast Uncertainties into Power Grid Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarov, Yuri V.; Huang, Zhenyu; Etingov, Pavel V.

2010-01-01

The power system balancing process, which includes the scheduling, real time dispatch (load following) and regulation processes, is traditionally based on deterministic models. Since the conventional generation needs time to be committed and dispatched to a desired megawatt level, the scheduling and load following processes use load and wind and solar power production forecasts to achieve future balance between the conventional generation and energy storage on the one side, and system load, intermittent resources (such as wind and solar generation), and scheduled interchange on the other side. Although in real life the forecasting procedures imply some uncertainty around the loadmore » and wind/solar forecasts (caused by forecast errors), only their mean values are actually used in the generation dispatch and commitment procedures. Since the actual load and intermittent generation can deviate from their forecasts, it becomes increasingly unclear (especially, with the increasing penetration of renewable resources) whether the system would be actually able to meet the conventional generation requirements within the look-ahead horizon, what the additional balancing efforts would be needed as we get closer to the real time, and what additional costs would be incurred by those needs. To improve the system control performance characteristics, maintain system reliability, and minimize expenses related to the system balancing functions, it becomes necessary to incorporate the predicted uncertainty ranges into the scheduling, load following, and, in some extent, into the regulation processes. It is also important to address the uncertainty problem comprehensively by including all sources of uncertainty (load, intermittent generation, generators’ forced outages, etc.) into consideration. All aspects of uncertainty such as the imbalance size (which is the same as capacity needed to mitigate the imbalance) and generation ramping requirement must be taken into account. The latter unique features make this work a significant step forward toward the objective of incorporating of wind, solar, load, and other uncertainties into power system operations. Currently, uncertainties associated with wind and load forecasts, as well as uncertainties associated with random generator outages and unexpected disconnection of supply lines, are not taken into account in power grid operation. Thus, operators have little means to weigh the likelihood and magnitude of upcoming events of power imbalance. In this project, funded by the U.S. Department of Energy (DOE), a framework has been developed for incorporating uncertainties associated with wind and load forecast errors, unpredicted ramps, and forced generation disconnections into the energy management system (EMS) as well as generation dispatch and commitment applications. A new approach to evaluate the uncertainty ranges for the required generation performance envelope including balancing capacity, ramping capability, and ramp duration has been proposed. The approach includes three stages: forecast and actual data acquisition, statistical analysis of retrospective information, and prediction of future grid balancing requirements for specified time horizons and confidence levels. Assessment of the capacity and ramping requirements is performed using a specially developed probabilistic algorithm based on a histogram analysis, incorporating all sources of uncertainties of both continuous (wind and load forecast errors) and discrete (forced generator outages and start-up failures) nature. A new method called the “flying brick” technique has been developed to evaluate the look-ahead required generation performance envelope for the worst case scenario within a user-specified confidence level. A self-validation algorithm has been developed to validate the accuracy of the confidence intervals.« less

Phase transition of a new lattice hydrodynamic model with consideration of on-ramp and off-ramp

NASA Astrophysics Data System (ADS)

Zhang, Geng; Sun, Di-hua; Zhao, Min

2018-01-01

A new traffic lattice hydrodynamic model with consideration of on-ramp and off-ramp is proposed in this paper. The influence of on-ramp and off-ramp on the stability of the main road is uncovered by theoretical analysis and computer simulation. Through linear stability theory, the neutral stability condition of the new model is obtained and the results show that the unstable region in the phase diagram is enlarged by considering the on-ramp effect but shrunk with consideration of the off-ramp effect. The mKdV equation near the critical point is derived via nonlinear reductive perturbation method and the occurrence of traffic jamming transition can be described by the kink-antikink soliton solution of the mKdV equation. From the simulation results of space-time evolution of traffic density waves, it is shown that the on-ramp can worsen the traffic stability of the main road but off-ramp is positive in stabilizing the traffic flow of the main road.

Precision linear ramp function generator

DOEpatents

Jatko, W.B.; McNeilly, D.R.; Thacker, L.H.

1984-08-01

A ramp function generator is provided which produces a precise linear ramp function which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

Precision linear ramp function generator

DOEpatents

Jatko, W. Bruce; McNeilly, David R.; Thacker, Louis H.

1986-01-01

A ramp function generator is provided which produces a precise linear ramp unction which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

Characterizing and analyzing ramping events in wind power, solar power, load, and netload

DOE PAGES

Cui, Mingjian; Zhang, Jie; Feng, Cong; ...

2017-04-07

Here, one of the biggest concerns associated with integrating a large amount of renewable energy into the power grid is the ability to handle large ramps in the renewable power output. For the sake of system reliability and economics, it is essential for power system operators to better understand the ramping features of renewable, load, and netload. An optimized swinging door algorithm (OpSDA) is used and extended to accurately and efficiently detect ramping events. For wind power ramps detection, a process of merging 'bumps' (that have a different changing direction) into adjacent ramping segments is included to improve the performancemore » of the OpSDA method. For solar ramps detection, ramping events that occur in both clear-sky and measured (or forecasted) solar power are removed to account for the diurnal pattern of solar generation. Ramping features are extracted and extensively compared between load and netload under different renewable penetration levels (9.77%, 15.85%, and 51.38%). Comparison results show that (i) netload ramp events with shorter durations and smaller magnitudes occur more frequently when renewable penetration level increases, and the total number of ramping events also increases; and (ii) different ramping characteristics are observed in load and netload even with a low renewable penetration level.« less

Forward masking of dynamic acoustic intensity: effects of intensity region and end-level.

PubMed

Olsen, Kirk N; Stevens, Catherine J

2012-01-01

Overestimation of loudness change typically occurs in response to up-ramp auditory stimuli (increasing intensity) relative to down-ramps (decreasing intensity) matched on frequency, duration, and end-level. In the experiment reported, forward masking is used to investigate a sensory component of up-ramp overestimation: persistence of excitation after stimulus presentation. White-noise and synthetic vowel 3.6 s up-ramp and down-ramp maskers were presented over two regions of intensity change (40-60 dB SPL, 60-80 dB SPL). Three participants detected 10 ms 1.5 kHz pure tone signals presented at masker-offset to signal-offset delays of 10, 20, 30, 50, 90, 170 ms. Masking magnitude was significantly greater in response to up-ramps compared with down-ramps for masker-signal delays up to and including 50 ms. When controlling for an end-level recency bias (40-60 dB SPL up-ramp vs 80-60 dB SPL down-ramp), the difference in masking magnitude between up-ramps and down-ramps was not significant at each masker-signal delay. Greater sensory persistence in response to up-ramps is argued to have minimal effect on perceptual overestimation of loudness change when response biases are controlled. An explanation based on sensory adaptation is discussed.

Integrated database and analysis system for the evaluation of freeway corridors for potential ramp signaling : [summary].

DOT National Transportation Integrated Search

2011-01-01

Ramp signaling is the installation of traffic signals on freeway on-ramps. Studies have shown that in many locations, ramp signaling helped alleviate traffic congestion and improve safety. However, not all freeway locations are suitable for ramp sign...

Rock ramp design guidelines

USGS Publications Warehouse

Mooney, David M.; Holmquist-Johnson, Christopher L.; Broderick, Susan

2007-01-01

Rock ramps or roughened channels consist of steep reaches stabilized by large immobile material (riprap). Primary objectives for rock ramps include: Create adequate head for diversionMaintain fish passage during low-flow conditionsMaintain hydraulic conveyance during high-flow conditionsSecondary objectives for rock ramp design include:Emulate natural systemsMinimize costsThe rock ramp consists of a low-flow channel designed to maintain biologically adequate depth and velocity conditions during periods of small discharges. The remainder of the ramp is designed to withstand and pass large flows with minimal structural damage. The following chapters outline a process for designing rock ramps.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Mingjian; Zhang, Jie; Feng, Cong

Here, one of the biggest concerns associated with integrating a large amount of renewable energy into the power grid is the ability to handle large ramps in the renewable power output. For the sake of system reliability and economics, it is essential for power system operators to better understand the ramping features of renewable, load, and netload. An optimized swinging door algorithm (OpSDA) is used and extended to accurately and efficiently detect ramping events. For wind power ramps detection, a process of merging 'bumps' (that have a different changing direction) into adjacent ramping segments is included to improve the performancemore » of the OpSDA method. For solar ramps detection, ramping events that occur in both clear-sky and measured (or forecasted) solar power are removed to account for the diurnal pattern of solar generation. Ramping features are extracted and extensively compared between load and netload under different renewable penetration levels (9.77%, 15.85%, and 51.38%). Comparison results show that (i) netload ramp events with shorter durations and smaller magnitudes occur more frequently when renewable penetration level increases, and the total number of ramping events also increases; and (ii) different ramping characteristics are observed in load and netload even with a low renewable penetration level.« less

Automatic detection of ECG cable interchange by analyzing both morphology and interlead relations.

PubMed

Han, Chengzong; Gregg, Richard E; Feild, Dirk Q; Babaeizadeh, Saeed

2014-01-01

ECG cable interchange can generate erroneous diagnoses. For algorithms detecting ECG cable interchange, high specificity is required to maintain a low total false positive rate because the prevalence of interchange is low. In this study, we propose and evaluate an improved algorithm for automatic detection and classification of ECG cable interchange. The algorithm was developed by using both ECG morphology information and redundancy information. ECG morphology features included QRS-T and P-wave amplitude, frontal axis and clockwise vector loop rotation. The redundancy features were derived based on the EASI™ lead system transformation. The classification was implemented using linear support vector machine. The development database came from multiple sources including both normal subjects and cardiac patients. An independent database was used to test the algorithm performance. Common cable interchanges were simulated by swapping either limb cables or precordial cables. For the whole validation database, the overall sensitivity and specificity for detecting precordial cable interchange were 56.5% and 99.9%, and the sensitivity and specificity for detecting limb cable interchange (excluding left arm-left leg interchange) were 93.8% and 99.9%. Defining precordial cable interchange or limb cable interchange as a single positive event, the total false positive rate was 0.7%. When the algorithm was designed for higher sensitivity, the sensitivity for detecting precordial cable interchange increased to 74.6% and the total false positive rate increased to 2.7%, while the sensitivity for detecting limb cable interchange was maintained at 93.8%. The low total false positive rate was maintained at 0.6% for the more abnormal subset of the validation database including only hypertrophy and infarction patients. The proposed algorithm can detect and classify ECG cable interchanges with high specificity and low total false positive rate, at the cost of decreased sensitivity for certain precordial cable interchanges. The algorithm could also be configured for higher sensitivity for different applications where a lower specificity can be tolerated. Copyright © 2014 Elsevier Inc. All rights reserved.

Magnetic flux pumping mechanism prevents sawtoothing in 3D nonlinear MHD simulations of tokamak plasmas

NASA Astrophysics Data System (ADS)

Krebs, Isabel; Jardin, Stephen C.; Guenter, Sibylle; Lackner, Karl; Hoelzl, Matthias; Strumberger, Erika; Ferraro, Nate

2017-10-01

3D nonlinear MHD simulations of tokamak plasmas have been performed in toroidal geometry by means of the high-order finite element code M3D-C1. The simulations are set up such that the safety factor on axis (q0) is driven towards values below unity. As reported in and the resulting asymptotic states either exhibit sawtooth-like reconnection cycling or they are sawtooth-free. In the latter cases, a self-regulating magnetic flux pumping mechanism, mainly provided by a saturated quasi-interchange instability via a dynamo effect, redistributes the central current density so that the central safety factor profile is flat and q0 1 . Sawtoothing is prevented if β is sufficiently high to allow for the necessary amount of flux pumping to counterbalance the tendency of the current density profile to centrally peak. We present the results of 3D nonlinear simulations based on specific types of experimental discharges and analyze their asymptotic behavior. A set of cases is presented where aspects of the current ramp-up phase of Hybrid ASDEX Upgrade discharges are mimicked. Another set of simulations is based on low-qedge discharges in DIII-D.

Safety analysis of the new synchronized and milwaukee B interchanges in comparison to existing designs.

PubMed

Molan, Amirarsalan Mehrara; Hummer, Joseph E

2017-12-01

Interchanges have high crash rates and large impacts on traffic operations. The main objective of this research is to analyze the safety performance of two new interchanges, the synchronized interchange and the Milwaukee B interchange. The primary method of study was microscopic simulation modeling using the Surrogate Safety Assessment Model (SSAM) program to estimate the quantity and type of conflicting interactions in each interchange. A comprehensive series of simulation scenarios were considered to include different conditions of traffic volumes, traffic turning ratios, traffic distribution, and heavy vehicles percentages. Afterward, outcomes were analyzed with two-way Analyses of Variance (ANOVAs) to compare the mean values of conflicts. Based on the results, the diverging diamond interchange (DDI) and Milwaukee B were the safest designs regarding observed conflicting interactions in the simulation models; however, the DDI did not seem as reliable from the viewpoint of wrong way movements. The new synchronized interchange, the parclo B, and the Milwaukee A (an existing interchange in Milwaukee, WI) showed the same rate of conflicts. The synchronized interchange may be advantageous because it was estimated to reduce the severity of crashes due to fewer crossing conflicts, a lower speed of conflicts, and a higher time to collision. The conventional diamond was the most dangerous design based on our measures. The DDI and the synchronized interchange look like plausible substitutes for reconstructing an unsafe diamond interchange due to the similarities in their required space. Copyright © 2017 Elsevier Ltd. All rights reserved.

Lack of behavioural responses of humpback whales (Megaptera novaeangliae) indicate limited effectiveness of sonar mitigation

PubMed Central

Kvadsheim, Petter H.; Lam, Frans-Peter A.; von Benda-Beckmann, Alexander M.; Sivle, Lise D.; Visser, Fleur; Curé, Charlotte; Tyack, Peter L.; Miller, Patrick J. O.

2017-01-01

ABSTRACT Exposure to underwater sound can cause permanent hearing loss and other physiological effects in marine animals. To reduce this risk, naval sonars are sometimes gradually increased in intensity at the start of transmission (‘ramp-up’). Here, we conducted experiments in which tagged humpback whales were approached with a ship to test whether a sonar operation preceded by ramp-up reduced three risk indicators – maximum sound pressure level (SPLmax), cumulative sound exposure level (SELcum) and minimum source–whale range (Rmin) – compared with a sonar operation not preceded by ramp-up. Whales were subject to one no-sonar control session and either two successive ramp-up sessions (RampUp1, RampUp2) or a ramp-up session (RampUp1) and a full-power session (FullPower). Full-power sessions were conducted only twice; for other whales we used acoustic modelling that assumed transmission of the full-power sequence during their no-sonar control. Averaged over all whales, risk indicators in RampUp1 (n=11) differed significantly from those in FullPower (n=12) by −3.0 dB (SPLmax), −2.0 dB (SELcum) and +168 m (Rmin), but not significantly from those in RampUp2 (n=9). Only five whales in RampUp1, four whales in RampUp2 and none in FullPower or control sessions avoided the sound source. For RampUp1, we found statistically significant differences in risk indicators between whales that avoided the sonar and whales that did not: −4.7 dB (SPLmax), −3.4 dB (SELcum) and +291 m (Rmin). In contrast, for RampUp2, these differences were smaller and not significant. This study suggests that sonar ramp-up has a positive but limited mitigative effect for humpback whales overall, but that ramp-up can reduce the risk of harm more effectively in situations when animals are more responsive and likely to avoid the sonar, e.g. owing to novelty of the stimulus, when they are in the path of an approaching sonar ship. PMID:29141878

Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line

PubMed Central

Desai, Aditya J.; Roberts, David J.

2014-01-01

The Calcium Sensing Receptor (CaSR) plays a role in calcium homeostasis by sensing minute changes in serum Ca2+ and modulating secretion of calciotropic hormones. It has been shown in transfected cells that accessory proteins known as Receptor Activity Modifying Proteins (RAMPs), specifically RAMPs 1 and 3, are required for cell-surface trafficking of the CaSR. These effects have only been demonstrated in transfected cells, so their physiological relevance is unclear. Here we explored CaSR/RAMP interactions in detail, and showed that in thyroid human carcinoma cells, RAMP1 is required for trafficking of the CaSR. Furthermore, we show that normal RAMP1 function is required for intracellular responses to ligands. Specifically, to confirm earlier studies with tagged constructs, and to provide the additional benefit of quantitative stoichiometric analysis, we used fluorescence resonance energy transfer to show equal abilities of RAMP1 and 3 to chaperone CaSR to the cell surface, though RAMP3 interacted more efficiently with the receptor. Furthermore, a higher fraction of RAMP3 than RAMP1 was observed in CaSR-complexes on the cell-surface, suggesting different ratios of RAMPs to CaSR. In order to determine relevance of these findings in an endogenous expression system we assessed the effect of RAMP1 siRNA knock-down in medullary thyroid carcinoma TT cells, (which express RAMP1, but not RAMP3 constitutively) and measured a significant 50% attenuation of signalling in response to CaSR ligands Cinacalcet and neomycin. Blockade of RAMP1 using specific antibodies induced a concentration-dependent reduction in CaSR-mediated signalling in response to Cinacalcet in TT cells, suggesting a novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking. These data provide evidence that RAMPs traffic the CaSR as higher-level oligomers and play a role in CaSR signalling even after cell surface localisation has occurred. PMID:24454825

Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.

PubMed

Desai, Aditya J; Roberts, David J; Richards, Gareth O; Skerry, Timothy M

2014-01-01

The Calcium Sensing Receptor (CaSR) plays a role in calcium homeostasis by sensing minute changes in serum Ca(2+) and modulating secretion of calciotropic hormones. It has been shown in transfected cells that accessory proteins known as Receptor Activity Modifying Proteins (RAMPs), specifically RAMPs 1 and 3, are required for cell-surface trafficking of the CaSR. These effects have only been demonstrated in transfected cells, so their physiological relevance is unclear. Here we explored CaSR/RAMP interactions in detail, and showed that in thyroid human carcinoma cells, RAMP1 is required for trafficking of the CaSR. Furthermore, we show that normal RAMP1 function is required for intracellular responses to ligands. Specifically, to confirm earlier studies with tagged constructs, and to provide the additional benefit of quantitative stoichiometric analysis, we used fluorescence resonance energy transfer to show equal abilities of RAMP1 and 3 to chaperone CaSR to the cell surface, though RAMP3 interacted more efficiently with the receptor. Furthermore, a higher fraction of RAMP3 than RAMP1 was observed in CaSR-complexes on the cell-surface, suggesting different ratios of RAMPs to CaSR. In order to determine relevance of these findings in an endogenous expression system we assessed the effect of RAMP1 siRNA knock-down in medullary thyroid carcinoma TT cells, (which express RAMP1, but not RAMP3 constitutively) and measured a significant 50% attenuation of signalling in response to CaSR ligands Cinacalcet and neomycin. Blockade of RAMP1 using specific antibodies induced a concentration-dependent reduction in CaSR-mediated signalling in response to Cinacalcet in TT cells, suggesting a novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking. These data provide evidence that RAMPs traffic the CaSR as higher-level oligomers and play a role in CaSR signalling even after cell surface localisation has occurred.

Ramp-related incidents involving wheeled mobility device users during transit bus boarding/alighting.

PubMed

Frost, Karen L; Bertocci, Gina; Smalley, Craig

2015-05-01

To estimate the prevalence of wheeled mobility device (WhMD) ramp-related incidents while boarding/alighting a public transit bus and to determine whether the frequency of incidents is less when the ramp slope meets the proposed Americans with Disabilities Act (ADA) maximum allowable limit of ≤9.5°. Observational study. Community public transportation. WhMD users (N=414) accessing a public transit bus equipped with an instrumented ramp. Not applicable. Prevalence of boarding/alighting incidents involving WhMD users and associated ramp slopes; factors affecting incidents. A total of 4.6% (n=35) of WhMD users experienced an incident while boarding/alighting a transit bus. Significantly more incidents occurred during boarding (6.3%, n=26) than during alighting (2.2%, n=9) (P<.01), and when the ramp was deployed to street level (mean slope=11.4°) compared with sidewalk level (mean slope=4.2°) (P=.01). The odds ratio for experiencing an incident when the ramp slope exceeded the proposed ADA maximum allowable ramp slope was 5.4 (95% confidence interval, 2.4-12.2; P<.01). The odds ratio for assistance being rendered to board/alight when the ramp slope exceeded the proposed ADA maximum allowable ramp slope was 5.1 (95% confidence interval, 2.9-9.0; P<.01). The findings of this study support the proposed ADA maximum allowable ramp slope of 9.5°. Ramp slopes >9.5° and ramps deployed to street level are associated with a higher frequency of incidents and provision of assistance. Transit agencies should increase awareness among bus operators of the effect kneeling and deployment location (street/sidewalk) have on the ramp slope. In addition, ramp components and the built environment may contribute to incidents. When prescribing WhMDs, skills training must include ascending/descending ramps at slopes encountered during boarding/alighting to ensure safe and independent access to public transit buses. Copyright © 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Reevaluation of Ramp Design Speed Criteria

DOT National Transportation Integrated Search

1999-12-01

Current freeway entry ramp design speed criteria were evaluated through observations of twenty ramps in four Texas cities. Field observations of ramp and freeway traffic speed-distance relationships were made using videotaping methods. Traffic operat...

Ramp sedimentation in the Dinantian limestones of the Shannon Trough, Co. Limerick, Ireland

NASA Astrophysics Data System (ADS)

Somerville, Ian D.; Strogen, Peter

1992-08-01

During the late Chadian and Arundian (Lower Carboniferous), an extensive carbonate ramp (Limerick Ramp) developed over County Limerick, southwest Ireland, dipping northwestwards. Three distinct facies can be recognised corresponding to position on this ramp: inner, mid- and outer ramp. The inner ramp facies of oolitic and crinoidal grainstones (Herbertstown Limestone Formation) in east Limerick formed a major shoal behind which peritidal limestones were deposited. The mid-ramp facies of muddy bioclastic limestones and shales (Cooperhill facies) in north Limerick formed between fairweather and storm wave bases. The outer ramp (basinal) facies of mudstones and thin graded resedimented limestones (Rathkeale Beds) in west Limerick developed below storm wave base when fine terrigenous input was high. Later in the Arundian there was progradation of the nearshore oolitic and crinoidal grainstones over the mid-ramp facies. By the Holkerian, the deep-water basinal facies in west Limerick was buried beneath mid-ramp facies (Durnish Limestone). The initiation of the Limerick Ramp is closely related to the formation of the Shannon Trough. In the late Courceyan, accelerated subsidence in the Shannon area during deposition of Waulsortian facies marked the onset of a sag phase. Following a quiescent period in early Chadian, subsidence was renewed in the late Chadian and Arundian, when major facies changes occurred on the ramp. Comparison of the Shannon Trough with the Dublin Basin shows that in the latter, tectonic events in the Chadian and Arundian, particularly syn-sedimentary faulting, created a sharp division between platform and basinal sedimentation. Such tectonic influence is not recognised in the Shannon Trough. Here differential subsidence and eustatic sea-level changes led to more permanent ramp existence, modified only by westwards progradation.

Is the activity of CGRP and Adrenomedullin regulated by RAMP (-2) and (-3) in Trypanosomatidae? An in-silico approach.

PubMed

Febres, Anthony; Vanegas, Oriana; Giammarresi, Michelle; Gomes, Carlos; Díaz, Emilia; Ponte-Sucre, Alicia

2018-07-01

The Calcitonin-Like Receptor (CLR) belongs to the classical seven-transmembrane segment molecules coupled to heterotrimeric G proteins. Its pharmacology depends on the simultaneous expression of the so-called Receptor Activity Modifier Proteins (RAMP-) -1, -2 and -3. RAMP-associated proteins modulate glycosylation and cellular traffic of CLR, therefore determining its pharmacodynamics. In higher eukaryotes, the complex formed by CLR and RAMP-1 is more akin to bind Calcitonin Gene-Related Peptide (CGRP), whereas those formed by CLR and RAMP-2 or RAMP-3, bind preferentially Adrenomedullin (AM). In lower eukaryotes, RAMPs, or any homologous protein, have not been identified until now. Herein we demonstrated a negative chemotactic response elicited by CGRP (10 -9 and 10 -8  M) and AM (10 -9 to 10 -5  M). Whether or not this response is receptor mediated should be verified, as well as the expression of a 24 kDa band in Leishmania, recognized by western blot analysis by the use of (human-)-RAMP-2 antibodies as detection probes. Queries with human RAMP-2 and RAMP-3 protein sequences in blastp against Leishmania (Viannia) braziliensis predicted proteome, allowed us to detect two sequence alignments in the parasite: A RAMP-2-aligned sequence corresponding to Leishmania folylpolyglutamate synthase (FPGS), and a RAMP-3 aligned protein, a hypothetical Leishmania protein with yet unknown function. The presence of homologous of these proteins was described in-silico in other members of the Trypanosomatidae. These preliminary and not yet complete data suggest the feasibility that both CGRP and Adrenomedullin activities may be regulated by homologs of RAMP- (-2) and (-3) in these parasites. Copyright © 2018 Elsevier B.V. All rights reserved.

San Antonio relay ramp: Area of stratal continuity between large-displacement barrier faults of the Edwards aquifer and Balcones fault zone, central Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, E.W.

1996-09-01

The San Antonio relay ramp, a gentle southwest-dipping monocline, formed between the tips of two en echelon master faults having maximum throws of >240 in. Structural analysis of this relay ramp is important to studies of Edwards aquifer recharge and ground-water flow because the ramp is an area of relatively good stratal continuity linking the outcrop belt recharge zone and unconfined aquifer with the downdip confined aquifer. Part of the relay ramp lies within the aquifer recharge zone and is crossed by several southeast-draining creeks, including Salado, Cibolo, and Comal Creeks, that supply water to the ramp recharge area. Thismore » feature is an analog for similar structures within the aquifer and for potential targets for hydrocarbons in other Gulf Coast areas. Defining the ramp is an {approximately}13-km-wide right step of the Edwards Group outcrop belt and the en echelon master faults that bound the ramp. The master faults strike N55-75{degrees}E, and maximum displacement exceeds the {approximately}165-m thickness of the Edwards Group strata. The faults therefore probably serve as barriers to Edwards ground-water flow. Within the ramp, tilted strata gently dip southwestward at {approximately}5 m/km, and the total structural relief along the ramp`s southwest-trending axis is <240 in. The ramp`s internal framework is defined by three fault blocks that are {approximately}4 to {approximately}6 km wide and are bound by northeast-striking faults having maximum throws between 30 and 150 m. Within the fault blocks, local areas of high fracture permeability may exist where smaller faults and joints are well connected.« less

Performance of alternative diamond interchange forms : volume I -- research report.

DOT National Transportation Integrated Search

2017-01-01

Service interchanges connect freeways to arterial roads and are the backbone of the U.S. road network. Improving the operations of service interchanges is possible by applying one of several new solutions: diverging diamond, single point interchanges...

Calcitonin and Amylin Receptor Peptide Interaction Mechanisms

PubMed Central

Lee, Sang-Min; Hay, Debbie L.; Pioszak, Augen A.

2016-01-01

Receptor activity-modifying proteins (RAMP1–3) determine the selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR) for calcitonin (CT), amylin (Amy), calcitonin gene-related peptide (CGRP), and adrenomedullin (AM) peptides. RAMP1/2 alter CLR selectivity for CGRP/AM in part by RAMP1 Trp-84 or RAMP2 Glu-101 contacting the distinct CGRP/AM C-terminal residues. It is unclear whether RAMPs use a similar mechanism to modulate CTR affinity for CT and Amy, analogs of which are therapeutics for bone disorders and diabetes, respectively. Here, we reproduced the peptide selectivity of intact CTR, AMY1 (CTR·RAMP1), and AMY2 (CTR·RAMP2) receptors using purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2-CTR ECD fusion proteins and antagonist peptides. All three proteins bound salmon calcitonin (sCT). Tethering RAMPs to CTR enhanced binding of rAmy, CGRP, and the AMY antagonist AC413. Peptide alanine-scanning mutagenesis and modeling of receptor-bound sCT and AC413 supported a shared non-helical CGRP-like conformation for their TN(T/V)G motif prior to the C terminus. After this motif, the peptides diverged; the sCT C-terminal Pro was crucial for receptor binding, whereas the AC413/rAmy C-terminal Tyr had little or no influence on binding. Accordingly, mutant RAMP1 W84A- and RAMP2 E101A-CTR ECD retained AC413/rAmy binding. ECD binding and cell-based signaling assays with antagonist sCT/AC413/rAmy variants with C-terminal residue swaps indicated that the C-terminal sCT/rAmy residue identity affects affinity more than selectivity. rAmy(8–37) Y37P exhibited enhanced antagonism of AMY1 while retaining selectivity. These results reveal unexpected differences in how RAMPs determine CTR and CLR peptide selectivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity. PMID:26895962

Disruption avoidance and fast ramp-down techniques for the DIII-D experimental scenarios

NASA Astrophysics Data System (ADS)

Barr, Jayson; Eidietis, N. W.; Humphreys, D. A.; Sammuli, B.; Luce, T.

2017-10-01

Plasma current ramp-down in ITER will continue in H-mode from 15 MA to 10 MA, and will keep a diverted shape until termination. This is in contrast to the limited ramp-down scenarios typically used in DIII-D operations. Additionally, fast emergency ramp-down scenarios for ITER and future reactors are a priority for disruption avoidance. New experiments in DIII-D use the ramp-down phase of a variety of experiments including in the ITER baseline scenario to survey and identify optimized ramp-down scenarios for both scheduled terminations and terminations triggered by off-normal event detection. Systematic scans in current ramp-rate (1-5 MA/s), neutral beam power (including βN feedback) and ramp-down shaping (limited versus continued diverted) have identified fast ramp-down scenarios for Lower Single Null (LSN) and Double Null (DN) plasmas. Scenario-specific methods and their rates of successful termination will be presented and compared relative to a historical data-set of ramp-down programming in the limiter configuration. Locked modes are found to be the most significant challenge to disruption avoidance in diverted ramp-downs. Results for LSN diverted discharges that begin the rampdown with large locked-modes will also be presented. If available, results of similar experiments on EAST will be presented. Work supported by US DOE under DE-FC02-04ER54698 and DE-SC0010685.

Hall effects on unsteady MHD flow of second grade fluid through porous medium with ramped wall temperature and ramped surface concentration

NASA Astrophysics Data System (ADS)

VeeraKrishna, M.; Chamkha, Ali J.

2018-05-01

The heat generation/absorption and thermo-diffusion on an unsteady free convective MHD flow of radiating and chemically reactive second grade fluid near an infinite vertical plate through a porous medium and taking the Hall current into account have been studied. Assume that the bounding plate has a ramped temperature with a ramped surface concentration and isothermal temperature with a ramped surface concentration. The analytical solutions for the governing equations are obtained by making use of the Laplace transforms technique. The velocity, temperature, and concentration profiles are discussed through graphs. We also found that velocity, temperature, and concentration profiles in the case of ramped temperature with ramped surface concentrations are less than those of isothermal temperature with ramped surface concentrations. Also, the expressions of the skin friction, Nusselt number, and Sherwood number are obtained and represented computationally through a tabular form.

Coastal eolian sand-ramp development related to paleo-sea-level changes during the Latest Pleistocene and Holocene (21–0 ka) in San Miguel Island, California, U.S.A.

USGS Publications Warehouse

Peterson, Curt D.; Erlandson, Jon M.; Stock, Errol; Hostetler, Steven W.; Price, David M.

2017-01-01

Coastal eolian sand ramps (5–130 m elevation) on the northern slope (windward) side of the small San Miguel Island (13 km in W-E length) range in age from late Pleistocene to modern time, though a major hiatus in sand-ramp growth occurred during the early Holocene marine transgression (16–9 ka). The Holocene sand ramps (1–5 m measured thicknesses) currently lack large dune forms, thereby representing deflated erosional remnants, locally covering thicker late Pleistocene sand-ramp deposits. The ramp sand was initially supplied from the adjacent island-shelf platform, extending about 20 km north of the present coastline. The sand-ramp deposits and interbedded loess soils were 14C dated using 112 samples from 32 archaeological sites and other geologic sections. Latest Pleistocene sand ramps (66–18 ka) were derived from across-shelf eolian sand transport during marine low stands. Shoreward wave transport supplied remobilized late Pleistocene sand from the inner shelf to Holocene beaches, where dominant NW winds supplied sand to the sand ramps. The onset dates of the sand-ramp deposition in San Miguel are 7.2 ± 1.5 ka (sample n = 14). The internal strata dates in the vertically accreting sand ramps are 3.4 ± 1.7 ka (n = 34). The sand ramps in San Miguel show wide-scale termination of sand supply in the latest Holocene time. The sand-ramp top dates or burial dates are 1.7 ± 0.9 ka (n = 28). The latest Holocene sand ramps are truncated along most of the island's northern coastline, indicating recent losses of nearshore sand reserves to onshore, alongshore, and, possibly, offshore sand sinks. The truncated sand ramps in San Miguel Island and in other sand-depleted marine coastlines provide warnings about future beach erosion and/or shoreline retreat from accelerated sea-level rise accompanying predicted global warming.

Evaluation of temporary ramp metering for work zones.

DOT National Transportation Integrated Search

2012-11-01

Ramp metering has been successfully implemented in many states to improve traffic operations on freeways. Studies have documented the positive mobility and safety benefits of ramp metering. However, there have been no studies on the use of ramp meter...

Supersonic Elliptical Ramp Inlet

NASA Technical Reports Server (NTRS)

Adamson, Eric E. (Inventor); Fink, Lawrence E. (Inventor); Fugal, Spencer R. (Inventor)

2016-01-01

A supersonic inlet includes a supersonic section including a cowl which is at least partially elliptical, a ramp disposed within the cowl, and a flow inlet disposed between the cowl and the ramp. The ramp may also be at least partially elliptical.

Lack of behavioural responses of humpback whales (Megaptera novaeangliae) indicate limited effectiveness of sonar mitigation.

PubMed

Wensveen, Paul J; Kvadsheim, Petter H; Lam, Frans-Peter A; von Benda-Beckmann, Alexander M; Sivle, Lise D; Visser, Fleur; Curé, Charlotte; Tyack, Peter L; Miller, Patrick J O

2017-11-15

Exposure to underwater sound can cause permanent hearing loss and other physiological effects in marine animals. To reduce this risk, naval sonars are sometimes gradually increased in intensity at the start of transmission ('ramp-up'). Here, we conducted experiments in which tagged humpback whales were approached with a ship to test whether a sonar operation preceded by ramp-up reduced three risk indicators - maximum sound pressure level (SPL max ), cumulative sound exposure level (SEL cum ) and minimum source-whale range ( R min ) - compared with a sonar operation not preceded by ramp-up. Whales were subject to one no-sonar control session and either two successive ramp-up sessions (RampUp1, RampUp2) or a ramp-up session (RampUp1) and a full-power session (FullPower). Full-power sessions were conducted only twice; for other whales we used acoustic modelling that assumed transmission of the full-power sequence during their no-sonar control. Averaged over all whales, risk indicators in RampUp1 ( n =11) differed significantly from those in FullPower ( n =12) by -3.0 dB (SPL max ), -2.0 dB (SEL cum ) and +168 m ( R min ), but not significantly from those in RampUp2 ( n =9). Only five whales in RampUp1, four whales in RampUp2 and none in FullPower or control sessions avoided the sound source. For RampUp1, we found statistically significant differences in risk indicators between whales that avoided the sonar and whales that did not: -4.7 dB (SPL max ), -3.4 dB (SEL cum ) and +291 m ( R min ). In contrast, for RampUp2, these differences were smaller and not significant. This study suggests that sonar ramp-up has a positive but limited mitigative effect for humpback whales overall, but that ramp-up can reduce the risk of harm more effectively in situations when animals are more responsive and likely to avoid the sonar, e.g. owing to novelty of the stimulus, when they are in the path of an approaching sonar ship. © 2017. Published by The Company of Biologists Ltd.

Static internal performance of convergent single-expansion-ramp nozzles with various combinations of internal geometric parameters

NASA Technical Reports Server (NTRS)

Bare, E. Ann; Capone, Francis J.

1989-01-01

An investigation was conducted in the Static Test Facility of the Langley 16-Foot Transonic Tunnel to determine the effects of five geometric design parameters on the internal performance of convergent single expansion ramp nozzles. The effects of ramp chordal angle, initial ramp angle, flap angle, flap length, and ramp length were determined. All nozzles tested has a nominally constant throat area and aspect ratio. Static pressure distributions along the centerlines of the ramp and flap were also obtained for each configuration. Nozzle pressure ratio was varied up to 10.0 for all configurations.

Effect of ramp configuration on easiness of handling, heart rate, and behavior of near-market weight pigs at unloading.

PubMed

Goumon, S; Faucitano, L; Bergeron, R; Crowe, T; Connor, M L; Gonyou, H W

2013-08-01

Three experiments, each using 280 pigs, were conducted in a simulated compartment to test the effect of angle of entrance (AOE) to the ramp (90°, 60°, 30°, or 0°), ramp slope (0°, 16°, 21°, or 26°), and an initial 20-cm step associated with 16° or 21° ramp slopes on the ease of handling, heart rate (HR), and behavior of near market-weight pigs during unloading. Heart rate (pigs and handler), unloading time, interventions of the handler, and reactions of the pigs were monitored. The results of the first experiment show that using a 90° AOE had detrimental effects on ease of handling (P < 0.05), HR of the pig (P < 0.05), and behavior (P < 0.05). The 0° and 30° AOE appeared to improve the ease of unloading, whereas the 60° AOE had an intermediate effect. The 30° AOE appeared to be preferable, because pigs moved at this angle balked less frequently (P < 0.01) and required less manipulation (P < 0.05) than pigs moved with a 0° AOE. The results of the second experiment show that the use of a flat ramp led to the easiest unloading, as demonstrated by the lower number of balks (P < 0.001) when pigs were moved to the ramp and less frequent use of paddle (P = 0.001) or voice (P < 0.001) on the ramp, compared with the other treatments. However, the flat ramp did not differ from the 21° ramp in many of the variables reflecting ease of handling, which may be explained by the difference in configuration between the ramps. The results also show that the use of the steepest ramp slope had the most detrimental effect on balking and backing up behavior of pigs (P < 0.001), and handling (touches, slaps, and pushes; P < 0.05 for all) when moved to the ramp and on unloading time (P < 0.01). No differences in pig HR (P < 0.05) and ease of handling on the ramp (P < 0.05) were found between a 26° and 16° ramp slope, suggesting that the length of the ramp may be one of the factors that make unloading more difficult. The results of the last experiment show that an initial step made unloading physically more demanding for the handler (P < 0.001) and pigs on the ramp (P < 0.05) as demonstrated by their greater HR. The greater difficulty of handling (P < 0.01) and reluctance to move (P < 0.05) of pigs moved toward the 16° ramp with a step suggest that pigs perceived this ramp as more psychologically challenging. Making a few changes in terms of the design of the ramp could improve the efficiency of handling and reduce stress in pigs.

Interstate Highway Interchanges Reshape Rural Communities.

ERIC Educational Resources Information Center

Moon, Henry E., Jr.

1987-01-01

Highway interchanges offer rural counties practically ready-made sites for development, but some interchanges offer better development opportunities than others. A study of a Kentucky interchange identified seven factors that make a difference in development, including traffic volume, distance to an urban area, ruggedness of terrain, and sale of…

Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.

PubMed

Armour, S L; Foord, S; Kenakin, T; Chen, W J

1999-12-01

Receptor-activity-modifying proteins (RAMPs) are a family of single transmembrane domain proteins shown to be important for the transport and ligand specificity of the calcitonin gene-related peptide (CGRP) receptor. In this report, we describe the analysis of pharmacological properties of the human calcitonin receptor (hCTR) coexpressed with different RAMPs with the use of the Xenopus laevis melanophore expression system. We show that coexpression of RAMP3 with human calcitonin receptor changed the relative potency of hCTR to human calcitonin (hCAL) and rat amylin. RAMP1 and RAMP2, in contrast, had little effect on the change of hCTR potency to hCAL or rat amylin. When coexpressed with RAMP3, hCTR reversed the relative potency by a 3.5-fold loss in sensitivity to hCAL and a 19-fold increase in sensitivity to rat amylin. AC66, an inverse agonist, produced apparent simple competitive antagonism of hCAL and rat amylin, as indicated by linear Schild regressions. The potency of AC66 was changed in the blockade of rat amylin but not hCAL responses with RAMP3 coexpression. The mean pK(B) for AC66 to hCAL was 9.4 +/- 0.3 without RAMP3 and 9.45 +/- 0.07 with RAMP3. For the antagonism of AC66 to rat amylin, the pK(B) was 9.25 +/- 0.15 without RAMP3 and 8.2 +/- 0.35 with RAMP3. The finding suggests that RAMP3 might modify the active states of calcitonin receptor in such a way as to create a new receptor phenotype that is "amylin-like." Irrespective of the physiological association of the new receptor species, the finding that a coexpressed membrane protein can completely change agonist and antagonist affinities for a receptor raises implications for screening in recombinant receptor systems.

Effectiveness of a multidisciplinary risk assessment and management programme-diabetes mellitus (RAMP-DM) on patient-reported outcomes.

PubMed

Wan, Eric Yuk Fai; Fung, Colman Siu Cheung; Wong, Carlos King Ho; Choi, Edmond Pui Hang; Jiao, Fang Fang; Chan, Anca Ka Chun; Chan, Karina Hiu Yen; Lam, Cindy Lo Kuen

2017-02-01

Little is known about how the patient-reported outcomes is influenced by multidisciplinary-risk-assessment-and-management-programme for patients with diabetes mellitus (RAMP-DM). This paper aims to evaluate the effectiveness of RAMP-DM on patient-reported outcomes. This was a prospective longitudinal study on 1039 diabetes mellitus patients (714/325 RAMP-DM/non-RAMP-DM) managed in primary care setting. 536 and 402 RAMP-DM participants, and 237 and 187 non-RAMP-DM participants were followed up at 12 and 24 months with completed survey, respectively. Patient-reported outcomes included health-related quality of life, change in global health condition and patient enablement measured by Short Form-12 Health Survey version-2 (SF-12v2), Global Rating Scale, Patient Enablement Instrument respectively. The effects of RAMP-DM on patient-reported outcomes were evaluated by mixed effect models. Subgroup analysis was performed by stratifying haemoglobin A1c (HbA1c) (optimal HbA1c < 7 % and suboptimal HbA1c ≥ 7 %). RAMP-DM with suboptimal HbA1c was associated with greater improvement in SF-12v2 physical component summary score at 12-month (coefficient:3.80; P-value < 0.05) and 24-month (coefficient:3.82;P-value < 0.05), more likely to feel more enabled at 12-month (odds ratio: 2.57; P-value < 0.05), and have improved in GRS at 24-month (odds ratio:4.05; P-value < 0.05) compared to non-RAMP-DM participants. However, there was no significant difference in patient-reported outcomes between RAMP-DM and non-RAMP-DM participants with optimal HbA1c. Participation in RAMP-DM is effective in improving physical component of HRQOL, Global Rating Scale and patient enablement among diabetes mellitus patients with suboptimal HbA1c, but not in those with optimal HbA1c. Patients with sub-optimal diabetes mellitus control should be the priority target population for RAMP-DM. This observational study design may have potential bias in the characteristics between groups, and randomized clinical trial is needed to confirm the results.

Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.

PubMed

Lee, Sang-Min; Hay, Debbie L; Pioszak, Augen A

2016-04-15

Receptor activity-modifying proteins (RAMP1-3) determine the selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR) for calcitonin (CT), amylin (Amy), calcitonin gene-related peptide (CGRP), and adrenomedullin (AM) peptides. RAMP1/2 alter CLR selectivity for CGRP/AM in part by RAMP1 Trp-84 or RAMP2 Glu-101 contacting the distinct CGRP/AM C-terminal residues. It is unclear whether RAMPs use a similar mechanism to modulate CTR affinity for CT and Amy, analogs of which are therapeutics for bone disorders and diabetes, respectively. Here, we reproduced the peptide selectivity of intact CTR, AMY1 (CTR·RAMP1), and AMY2 (CTR·RAMP2) receptors using purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2-CTR ECD fusion proteins and antagonist peptides. All three proteins bound salmon calcitonin (sCT). Tethering RAMPs to CTR enhanced binding of rAmy, CGRP, and the AMY antagonist AC413. Peptide alanine-scanning mutagenesis and modeling of receptor-bound sCT and AC413 supported a shared non-helical CGRP-like conformation for their TN(T/V)G motif prior to the C terminus. After this motif, the peptides diverged; the sCT C-terminal Pro was crucial for receptor binding, whereas the AC413/rAmy C-terminal Tyr had little or no influence on binding. Accordingly, mutant RAMP1 W84A- and RAMP2 E101A-CTR ECD retained AC413/rAmy binding. ECD binding and cell-based signaling assays with antagonist sCT/AC413/rAmy variants with C-terminal residue swaps indicated that the C-terminal sCT/rAmy residue identity affects affinity more than selectivity. rAmy(8-37) Y37P exhibited enhanced antagonism of AMY1 while retaining selectivity. These results reveal unexpected differences in how RAMPs determine CTR and CLR peptide selectivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Static internal performance of single-expansion-ramp nozzles with various combinations of internal geometric parameters

NASA Technical Reports Server (NTRS)

Re, R. J.; Leavitt, L. D.

1984-01-01

The effects of five geometric design parameters on the internal performance of single-expansion-ramp nozzles were investigated at nozzle pressure ratios up to 10 in the static-test facility of the Langley 16-Foot Transonic Tunnel. The geometric variables on the expansion-ramp surface of the upper flap consisted of ramp chordal angle, ramp length, and initial ramp angle. On the lower flap, the geometric variables consisted of flap angle and flap length. Both internal performance and static-pressure distributions on the centerlines of the upper and lower flaps were obtained for all 43 nozzle configurations tested.

77 FR 9266 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... Interchangeable Virtual Instruments Foundation, Inc. intends to file additional written notifications disclosing...

The Discourse of Making Amends: A Grammar of Remedial Interchanges.

ERIC Educational Resources Information Center

Walton, Marsha D.

Narrative observations were made of remedial interchanges occurring among school children (K-4) in open classrooms. Transcripts of interchanges were typed move by move and coded according to a hierarchical coding scheme (remedy, defiance, no response, relief, ending, and ambiguous). The interchanges of the kindergarteners and first graders were…

"Fiberoptic variable message signs" : Swift Interchange - Delta Park Interchange Section, Pacific Highway (Interstate 5) : final report.

DOT National Transportation Integrated Search

1995-02-01

The SYLVIA fiberoptic variable message signs (VMS) were installed on the Pacific Highway (I-5) as a part of the "Swift Interchange - Delta Park Interchange" project at milepost 298.47 and at milepost 305.66 in January 1991. Initially, during project ...

Programmer's guide to the fuzzy logic ramp metering algorithm : software design, integration, testing, and evaluation

DOT National Transportation Integrated Search

2000-02-01

A Fuzzy Logic Ramp Metering Algorithm was implemented on 126 ramps in the greater Seattle area. This report documents the implementation of the Fuzzy Logic Ramp Metering Algorithm at the Northwest District of the Washington State Department of Transp...

Safety and operational performance evaluation of four types of exit ramps on Florida's freeways (final report).

DOT National Transportation Integrated Search

2010-12-01

This project mainly focuses on exit ramp performance analysis of safety and operations. In addition, issues of advance guide sign for exit ramp are also mentioned. : Safety analysis evaluates safety performances of different exit ramps used in Florid...

Separation attenuation in swept shock wave-boundary-layer interactions using different microvortex generator geometries

NASA Astrophysics Data System (ADS)

Martis, R. R.; Misra, A.

2017-09-01

A numerical study is conducted to determine the effectiveness of six different microvortex generator geometries in controlling swept shock wave/boundary-layer interactions. The geometries considered are base ramp, base ramp with declining angle of 45°, blunt ramp, split ramp, thick vanes, and ramped vanes. Microvortex generators with a gap were found to be better suited for delaying the separation. Thick vanes showed the largest delay in separation among the devices studied.

Magnetic ramp scale at supercritical perpendicular collisionless shocks: Full particle electromagnetic simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Zhongwei; SOA Key Laboratory for Polar Science, Polar Research Institute of China, Shanghai, 200136; Lu, Quanming

2013-09-15

Supercritical perpendicular collisionless shocks are known to exhibit foot, ramp, and overshoot structures. The shock ramp structure is in a smaller scale in contrast to other microstructures (foot and overshoot) within the shock front. One-dimensional full particle simulations of strictly perpendicular shocks over wide ranges of ion beta β{sub i}, Alfvén Mach number M{sub A}, and ion-to-electron mass ratio m{sub i}/m{sub e} are presented to investigate the impact of plasma parameters on the shock ramp scale. Main results are (1) the ramp scale can be as small as several electron inertial length. (2) The simulations suggest that in a regimemore » below the critical ion beta value, the shock front undergoes a periodic self-reformation and the shock ramp scale is time-varying. At higher ion beta values, the shock front self-reformation is smeared. At still higher ion beta value, the motion of reflected ions is quite diffuse so that they can lead to a quasi-steady shock ramp. Throughout the above three conditions, the shock ramp thickness increases with β{sub i}. (3) The increase (decrease) in Mach number and the decrease (increase) in the beta value have almost equivalent impact on the state (i.e., stationary or nonstationary) of the shock ramp. Both of front and ramp thicknesses are increased with M{sub A}.« less

40 CFR 1033.520 - Alternative ramped modal cycles.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Following the completion of the third test phase of the applicable ramped modal cycle, conduct the post... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM LOCOMOTIVES Test Procedures § 1033.520 Alternative ramped modal... locomotive notch settings. Ramped modal cycles combine multiple test modes of a discrete-mode steady-state...

3. Ramp No. 6 connection between Medical Detachment Barracks: Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Ramp No. 6 connection between Medical Detachment Barracks: Building Nos. 9970-B (left) and 9969-B (right). The many windows makes this section almost unique among the ramps and corridors. - Madigan Hospital, Corridors & Ramps, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

Analysis of genome rearrangement by block-interchanges.

PubMed

Lu, Chin Lung; Lin, Ying Chih; Huang, Yen Lin; Tang, Chuan Yi

2007-01-01

Block-interchanges are a new kind of genome rearrangements that affect the gene order in a chromosome by swapping two nonintersecting blocks of genes of any length. More recently, the study of such rearrangements is becoming increasingly important because of its applications in molecular evolution. Usually, this kind of study requires to solve a combinatorial problem, called the block-interchange distance problem, which is to find a minimum number of block-interchanges between two given gene orders of linear/circular chromosomes to transform one gene order into another. In this chapter, we shall introduce the basics of block-interchange rearrangements and permutation groups in algebra that are useful in analyses of genome rearrangements. In addition, we shall present a simple algorithm on the basis of permutation groups to efficiently solve the block-interchange distance problem, as well as ROBIN, a web server for the online analyses of block-interchange rearrangements.

76 FR 80405 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... in this group research project remains open, and Interchangeable Virtual Instruments Foundation, Inc...

78 FR 117 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-02

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... research project. Membership in this group research project remains open, and Interchangeable Virtual...

76 FR 29267 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... in this group research project remains open, and Interchangeable Virtual Instruments Foundation, Inc...

75 FR 28294 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... remains open, and Interchangeable Virtual Instruments Foundation, Inc. intends to file additional written...

76 FR 16820 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... research project. Membership in this group research project remains open, and Interchangeable Virtual...

75 FR 54652 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Interchangeable...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... group research project remains open, and Interchangeable Virtual Instruments Foundation, Inc. intends to...

32 CFR 644.409 - Procedures for Interchange of National Forest Lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Procedures for Interchange of National Forest... Interests § 644.409 Procedures for Interchange of National Forest Lands. (a) General. The interchange of national forest lands is accomplished in three steps: first, agreement must be reached between the two...

Effect of therapeutic interchange on medication reconciliation during hospitalization and upon discharge in a geriatric population

PubMed Central

Wang, Jessica S.; Fogerty, Robert L.

2017-01-01

Background Therapeutic interchange of a same class medication for an outpatient medication is a widespread practice during hospitalization in response to limited hospital formularies. However, therapeutic interchange may increase risk of medication errors. The objective was to characterize the prevalence and safety of therapeutic interchange. Methods and findings Secondary analysis of a transitions of care study. We included patients over age 64 admitted to a tertiary care hospital between 2009–2010 with heart failure, pneumonia, or acute coronary syndrome who were taking a medication in any of six commonly-interchanged classes on admission: proton pump inhibitors (PPIs), histamine H2-receptor antagonists (H2 blockers), hydroxymethylglutaryl CoA reductase inhibitors (statins), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and inhaled corticosteroids (ICS). There was limited electronic medication reconciliation support available. Main measures were presence and accuracy of therapeutic interchange during hospitalization, and rate of medication reconciliation errors on discharge. We examined charts of 303 patients taking 555 medications at time of admission in the six medication classes of interest. A total of 244 (44.0%) of medications were therapeutically interchanged to an approved formulary drug at admission, affecting 64% of the study patients. Among the therapeutically interchanged drugs, we identified 78 (32.0%) suspected medication conversion errors. The discharge medication reconciliation error rate was 11.5% among the 244 therapeutically interchanged medications, compared with 4.2% among the 311 unchanged medications (relative risk [RR] 2.75, 95% confidence interval [CI] 1.45–5.19). Conclusions Therapeutic interchange was prevalent among hospitalized patients in this study and elevates the risk for potential medication errors during and after hospitalization. Improved electronic systems for managing therapeutic interchange and medication reconciliation may be valuable. PMID:29049325

Vehicle operation characteristic under different ramp entrance conditions in underground road: Analysis, simulation and modelling

NASA Astrophysics Data System (ADS)

Yao, Qiming; Liu, Shuo; Liu, Yang

2018-05-01

An experimental design was used to study the vehicle operation characteristics of different ramp entrance conditions in underground road. With driving simulator, the experimental scenarios include left or right ramp with first, second and third service level, respectively, to collect vehicle speed, acceleration, lateral displacement and location information at the ramp entrance section. By using paired t-test and ANOVA, the influence factors of vehicle operating characteristics are studied. The result shows that effects of ramp layout and mainline traffic environment on vehicle operation characteristics are significant. The regression model of vehicle traveling distance on acceleration lane is established. Suggestions are made for ramp entrance design of underground road.

Development and evaluation of RAMP I - a practitioner's tool for screening of musculoskeletal disorder risk factors in manual handling.

PubMed

Lind, Carl Mikael; Forsman, Mikael; Rose, Linda Maria

2017-10-16

RAMP I is a screening tool developed to support practitioners in screening for work-related musculoskeletal disorder risk factors related to manual handling. RAMP I, which is part of the RAMP tool, is based on research-based studies combined with expert group judgments. More than 80 practitioners participated in the development of RAMP I. The tool consists of dichotomous assessment items grouped into seven categories. Acceptable reliability was found for a majority of the assessment items for 15 practitioners who were given 1 h of training. The usability evaluation points to RAMP I being usable for screening for musculoskeletal disorder risk factors, i.e., usable for assessing risks, being usable as a decision base, having clear results and that the time needed for an assessment is acceptable. It is concluded that RAMP I is a usable tool for practitioners.

Effects of ramp reset pulses on the address discharge in a shadow mask plasma display panel

NASA Astrophysics Data System (ADS)

Yang, Lanlan; Tu, Yan; Zhang, Xiong; Jiang, Youyan; Zhang, Jian; Wang, Baoping

2007-05-01

A two-dimensional self-consistent numerical simulation model is used to analyse the effects of the ramp reset pulses on the address discharge in a shadow mask plasma display panel (SM-PDP). Some basic parameters such as the slope of the ramp pulse and the terminal voltage of the ramp reset period are varied to investigate their effects. The simulation results illustrate that the wall voltage is mainly decided by the terminal voltage and the firing voltage at the end of the ramp reset period. Moreover, the variation of the ramp slope will also bring a few modifications to the wall voltage. The priming particles in the beginning of the addressing period are related to the slope of the ramping down voltage pulse. The simulation results can help us optimize the driving scheme of the SM-PDP.

A microfluidic separation platform using an array of slanted ramps

NASA Astrophysics Data System (ADS)

Risbud, Sumedh; Bernate, Jorge; Drazer, German

2013-03-01

The separation of the different components of a sample is a crucial step in many micro- and nano-fluidic applications, including the detection of infections, the capture of circulating tumor cells, the isolation of proteins, RNA and DNA, to mention but a few. Vector chromatography, in which different species migrate in different directions in a planar microfluidic device thus achieving spatial as well as temporal resolution, offers the promise of high selectivity along with high throughput. In this work, we present a microfluidic vector chromatography platform consisting of slanted ramps in a microfluidic channel for the separation of suspended particles. We construct these ramps using inclined UV lithography, such that the inclined portion of the ramps is upstream. We show that particles of different size displace laterally to a different extent when driven by a flow field over a slanted ramp. The flow close to the ramp reorients along the ramp, causing the size-dependent deflection of the particles. The cumulative effect of an array of these ramps would cause particles of different size to migrate in different directions, thus allowing their passive and continuous separation.

Modeling effectiveness of gradual increases in source level to mitigate effects of sonar on marine mammals.

PubMed

Von Benda-Beckmann, Alexander M; Wensveen, Paul J; Kvadsheim, Petter H; Lam, Frans-Peter A; Miller, Patrick J O; Tyack, Peter L; Ainslie, Michael A

2014-02-01

Ramp-up or soft-start procedures (i.e., gradual increase in the source level) are used to mitigate the effect of sonar sound on marine mammals, although no one to date has tested whether ramp-up procedures are effective at reducing the effect of sound on marine mammals. We investigated the effectiveness of ramp-up procedures in reducing the area within which changes in hearing thresholds can occur. We modeled the level of sound killer whales (Orcinus orca) were exposed to from a generic sonar operation preceded by different ramp-up schemes. In our model, ramp-up procedures reduced the risk of killer whales receiving sounds of sufficient intensity to affect their hearing. The effectiveness of the ramp-up procedure depended strongly on the assumed response threshold and differed with ramp-up duration, although extending the duration of the ramp up beyond 5 min did not add much to its predicted mitigating effect. The main factors that limited effectiveness of ramp up in a typical antisubmarine warfare scenario were high source level, rapid moving sonar source, and long silences between consecutive sonar transmissions. Our exposure modeling approach can be used to evaluate and optimize mitigation procedures. © 2013 Society for Conservation Biology.

The influence of heavy vehicles on traffic dynamics around on-ramp system: Cellular automata approach

NASA Astrophysics Data System (ADS)

Kong, Dewen; Guo, Xiucheng; Wu, Dingxin

Although the on-ramp system has been widely studied, the influence of heavy vehicles is unknown because researchers only investigate the traffic dynamics around on-ramp system under homogeneous traffic conditions, which is different in real-world settings. This paper uses an improved cellular automaton model to study the heterogeneous traffic around on-ramp system. The forward motion rules are improved by considering the differences of driving behavior in different vehicle combinations. The lane change rules are improved by reflecting the aggressive behavior in mandatory lane changes. The phase diagram, traffic flow, capacity and spatial-temporal diagram are analyzed under the influences of heavy vehicles. The results show that by increasing the percentage of heavy vehicles, there will be more severe traffic congestion around on-ramp system, lower saturated flow and capacity. Also, the interactions between main road and on-ramp have been investigated. Increasing the percentage of heavy vehicles at the upstream of the conflict area on the main road or restricting heavy vehicles on the outside lane of the main road will deteriorate the performance of on-ramp. While the main road will have better performance as the percentage of heavy vehicles on the on-ramp increases when the on-ramp inflow rate is not low.

Successful lyophilization by adopting a fast ramp rate during primary drying in protein formulations.

PubMed

Ohori, Ryo; Akita, Tomomi; Yamashita, Chikamasa

2018-06-15

In the lyophilization process for injections, the shelf temperature (T s ) and chamber pressure (P c ) have mainly been investigated to optimize the primary drying process. The objective of this study was to show that lyophilization of protein formulations can be achieved by adopting a fast ramp rate of T s in the beginning of the primary drying process. Bovine serum albumin was used as the model protein, and seven different lyophilized formulations obtained were stored at elevated temperature. We found that although acceptable cake appearance was confirmed by the fast ramp cycle, all formulations of lyophilized cakes obtained by the slow ramp cycle severely collapsed (macrocollapse). It is thought that the collapse in the slow ramp cycle occurred during the shelf ramp in the beginning of primary drying and that insufficient removal of water from the dried matrix caused viscous flow (product collapse). Regarding storage stability, moisture-induced degradation was confirmed in some of the formulations prepared by the slow ramp cycle, whereas all lyophilized BSA formulations prepared by the fast ramp cycle were stable. Thus, the results indicate that the ramp rate appears to be one of the critical operational parameters required to establish a successful lyophilization cycle. Copyright © 2018. Published by Elsevier B.V.

Assessment of interchangeability rate between 2 methods of measurements: An example with a cardiac output comparison study.

PubMed

Lorne, Emmanuel; Diouf, Momar; de Wilde, Robert B P; Fischer, Marc-Olivier

2018-02-01

The Bland-Altman (BA) and percentage error (PE) methods have been previously described to assess the agreement between 2 methods of medical or laboratory measurements. This type of approach raises several problems: the BA methodology constitutes a subjective approach to interchangeability, whereas the PE approach does not take into account the distribution of values over a range. We describe a new methodology that defines an interchangeability rate between 2 methods of measurement and cutoff values that determine the range of interchangeable values. We used a simulated data and a previously published data set to demonstrate the concept of the method. The interchangeability rate of 5 different cardiac output (CO) pulse contour techniques (Wesseling method, LiDCO, PiCCO, Hemac method, and Modelflow) was calculated, in comparison with the reference pulmonary artery thermodilution CO using our new method. In our example, Modelflow with a good interchangeability rate of 93% and a cutoff value of 4.8 L min, was found to be interchangeable with the thermodilution method for >95% of measurements. Modelflow had a higher interchangeability rate compared to Hemac (93% vs 86%; P = .022) or other monitors (Wesseling cZ = 76%, LiDCO = 73%, and PiCCO = 62%; P < .0001). Simulated data and reanalysis of a data set comparing 5 CO monitors against thermodilution CO showed that, depending on the repeatability of the reference method, the interchangeability rate combined with a cutoff value could be used to define the range of values over which interchangeability remains acceptable.

Evaluation of WRF-Predicted Near-Hub-Height Winds and Ramp Events over a Pacific Northwest Site with Complex Terrain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Qing; Berg, Larry K.; Pekour, Mikhail

The WRF model version 3.3 is used to simulate near hub-height winds and power ramps utilizing three commonly used planetary boundary-layer (PBL) schemes: Mellor-Yamada-Janjic (MYJ), University of Washington (UW), and Yonsei University (YSU). The predicted winds have small mean biases compared with observations. Power ramps and step changes (changes within an hour) consistently show that the UW scheme performed better in predicting up ramps under stable conditions with higher prediction accuracy and capture rates. Both YSU and UW scheme show good performance predicting up- and down- ramps under unstable conditions with YSU being slightly better for ramp durations longer thanmore » an hour. MYJ is the most successful simulating down-ramps under stable conditions. The high wind speed and large shear associated with low-level jets are frequently associated with power ramps, and the biases in predicted low-level jet explain some of the shown differences in ramp predictions among different PBL schemes. Low-level jets were observed as low as ~200 m in altitude over the Columbia Basin Wind Energy Study (CBWES) site, located in an area of complex terrain. The shear, low-level peak wind speeds, as well as the height of maximum wind speed are not well predicted. Model simulations with 3 PBL schemes show the largest variability among them under stable conditions.« less

Comprehensive School Counseling Programs and Student Achievement Outcomes: A Comparative Analysis of Ramp versus Non-Ramp Schools

ERIC Educational Resources Information Center

Wilkerson, Kevin; Perusse, Rachelle; Hughes, Ashley

2013-01-01

This study compares school-wide Annual Yearly Progress (AYP) results in Indiana schools earning the Recognized ASCA Model Program (RAMP) designation (n = 75) with a sample of control schools stratified by level and locale (n = 226). K-12 schools earning the RAMP designation in 2007, 2008, and 2009 comprise the experimental group. Findings indicate…

29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of... simultaneous use of the ramp by vehicles and pedestrians. (d) Ramp maintenance. Ramps shall be properly...: (1) Sufficient power to ascend ramp inclines safely; and (2) Sufficient braking capacity to descend...

29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

Code of Federal Regulations, 2011 CFR

2011-07-01

... simultaneous use of the ramp by vehicles and pedestrians. (d) Ramp maintenance. Ramps shall be properly... ramp inclines safely. (j) Safe speeds. Power driven vehicles used in Ro-Ro operations shall be operated at speeds that are safe for prevailing conditions. (k) Ventilation. Internal combustion engine-driven...

Experimental Investigation of Transverse Supersonic Gaseous Injection Enhancement Into Supersonic Flow

DTIC Science & Technology

1996-12-01

Ramp AR 2........................................................ A.2 A. 9 . Test Section, No Injection or PME Ramp...B.2 B.8. Wide Ramp AR 1 ......................................................... B.2 B. 9 . Narrow Ramp AR 2...identified as a major near-field mixing factor.5 𔄀 While work has continued in transverse injection, 7𔄂 ’ 9 later studies sought to produce greater

Rover deployment system for lunar landing mission

NASA Astrophysics Data System (ADS)

Sutoh, Masataku; Hoshino, Takeshi; Wakabayashi, Sachiko

2017-09-01

For lunar surface exploration, a deployment system is necessary to allow a rover to leave the lander. The system should be as lightweight as possible and stored retracted when launched. In this paper, two types of retractable deployment systems for lunar landing missions, telescopic- and fold-type ramps, are discussed. In the telescopic-type system, a ramp is stored with the sections overlapping and slides out during deployment. In the fold-type system, it is stored folded and unfolds for the deployment. For the development of these ramps, a design concept study and structural analysis were conducted first. Subsequently, ramp deployment and rover release tests were performed using the developed ramp prototypes. Through these tests, the validity of their design concepts and functions have been confirmed. In the rover release test, it was observed that the developed lightweight ramp was sufficiently strong for a 50-kg rover to descend. This result suggests that this ramp system is suitable for the deployment of a 300-kg-class rover on the Moon, where the gravity is about one-sixth that on Earth. The lightweight and sturdy ramp developed in this study will contribute to both safe rover deployment and increase of lander/rover payload.

Study on traffic characteristics for a typical expressway on-ramp bottleneck considering various merging behaviors

NASA Astrophysics Data System (ADS)

Sun, Jie; Li, Zhipeng; Sun, Jian

2015-12-01

Recurring bottlenecks at freeway/expressway are considered as the main cause of traffic congestion in urban traffic system while on-ramp bottlenecks are the most significant sites that may result in congestion. In this paper, the traffic bottleneck characteristics for a simple and typical expressway on-ramp are investigated by the means of simulation modeling under the open boundary condition. In simulations, the running behaviors of each vehicle are described by a car-following model with a calibrated optimal velocity function, and lane changing actions at the merging section are modeled by a novel set of rules. We numerically derive the traffic volume of on-ramp bottleneck under different upstream arrival rates of mainline and ramp flows. It is found that the vehicles from the ramp strongly affect the pass of mainline vehicles and the merging ratio changes with the increasing of ramp vehicle, when the arrival rate of mainline flow is greater than a critical value. In addition, we clarify the dependence of the merging ratio of on-ramp bottleneck on the probability of lane changing and the length of the merging section, and some corresponding intelligent control strategies are proposed in actual traffic application.

Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation.

PubMed

Song, Kwang Hoon; Lee, Jaehyun; Jung, Hong-Ryul; Park, HyoungJun; Doh, Junsang

2017-09-14

T cells navigate diverse microenvironments to perform immune responses. Micro-scale topographical structures within the tissues, which may inherently exist in normal tissues or may be formed by inflammation or injury, can influence T cell migration, but how T cell migration is affected by such topographical structures have not been investigated. In this study, we fabricated ramp-like structures with a 5 μm height and various slopes, and observed T cells climbing up the ramp-like structures. T cells encountering the ramp-like structures exhibited MLC accumulation near head-tail junctions contacting the ramp-like structures, and made turns to the direction perpendicular to the ramp-like structures. Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (MLCK) were responsible for the intriguing turning behavior of T cells climbing the ramp-like structures. Arp2/3 or MLCK inhibition substantially reduced probability of T cells climbing sharp-edged ramp-like structures, indicating intriguing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be important for T cells to access inflamed or injured tissues with abrupt topographical changes.

75 FR 62919 - Notice of Final Federal Agency Actions on the Route 250 Bypass Interchange at McIntire Road...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-13

... on the Route 250 Bypass Interchange at McIntire Road Project in Virginia AGENCY: Federal Highway.... 139(l)(1). The actions relate to the Route 250 Bypass Interchange at McIntire Road project in the City... Virginia: Route 250 Bypass Interchange at McIntire Road. The project would involve construction of a grade...

Terasaki Spiral Ramps in the Rough Endoplasmic Reticulum

NASA Astrophysics Data System (ADS)

Guven, Jemal; Huber, Greg; Valencia, Dulce María

2014-10-01

We present a model describing the morphology as well as the assembly of "Terasaki ramps," the recently discovered helicoidal connections linking adjacent sheets of the rough endoplasmic reticulum (ER). The fundamental unit is a localized symmetric double-ramped "parking garage" formed by two separated gently pitched, approximately helicoidal, ramps of opposite chiralities. This geometry is stabilized by a short-range repulsive interaction between ramps associated with bending energy which opposes the long-range attraction associated with tension. The ramp inner boundaries are themselves stabilized by the condensation of membrane-shaping proteins along their length. A mechanism for parking garage self-assembly is proposed involving the nucleation of dipoles at the center of tubular three-way junctions within the smooth ER. Our predictions are compared with the experimental data.

Use of a complete starter feed in grain adaptation programs for feedlot cattle.

PubMed

Schneider, C J; Nuttelman, B L; Shreck, A L; Burken, D B; Griffin, W A; Gramkow, J L; Stock, R A; Klopfenstein, T J; Erickson, G E

2017-08-01

Four experiments evaluated the use of a complete starter feed (RAMP; Cargill Corn Milling, Blair, NE) for grain adaptation. In Exp. 1, 229 yearling steers (397 ± 28.4 kg BW) were used to compare a traditional adaptation program (CON) with adapting cattle with RAMP in either a 1- (RAMP-1RS) or 2- (RAMP-2RS) ration system. From d 23 to slaughter, cattle were fed a common finishing diet. In Exp. 2, 390 yearling steers (341 ± 14 kg BW) were used to compare accelerated grain adaptation programs with RAMP with 2 control treatments where RAMP was blended with a finishing diet containing either 25 (CON25) or 47.5% (CON47) Sweet Bran (Cargill Corn Milling) in 4 steps fed over 24 d to adapt cattle. Rapid adaptation treatments involved feeding RAMP for 10 d followed by a blend of RAMP and a 47% Sweet Bran finishing diet to transition cattle with 3 blends fed for 1 d each (3-1d), 2 blends fed for 2 d each (2-2d), or 1 blend fed for 4 d (1-4d). From d 29 to slaughter, all cattle were fed a common finishing diet. In Exp. 3, 300 steer calves (292 ± 21 kg BW) were used to compare the CON47 and 1-4d adaptation programs with directly transitioning cattle from RAMP, which involved feeding RAMP for 10 d and then switching directly to F1 on d 11 (1-STEP). From d 29 until slaughter, F2 was fed to all cattle. In Exp. 4, 7 ruminally fistulated steers (482 ± 49 kg BW) were used in a 35-d trial to compare the CON47 and 1-STEP adaptation programs. Ruminal pH and intake data from the first 6 d of F1and first 6 d of F2 were used to compare adaptation systems. Adaptation with RAMP-1RS and RAMP-2RS increased ( < 0.01) G:F compared with cattle adapted using CON in Exp. 1. Feeding RAMP-1RS increased ADG ( = 0.03) compared with CON. Intakes were similar ( = 0.39) among treatments. Daily gain, DMI, G:F, and carcass traits were similar ( > 0.11) among treatments in Exp. 2. Daily gain, DMI, and G:F were not different ( > 0.20) among treatments on d 39 or over the entire feeding period in Exp. 3. When F1 or F2 was being fed, DMI was similar ( ≥ 0.40) for CON47 and 1-STEP in Exp. 4. When F1 or F2 was being fed, 1-STEP cattle had lower average ruminal pH ( ≤ 0.03) and greater time below a pH of 5.3 ( ≤ 0.03). Using RAMP for grain adaptation improved performance compared with traditional adaptation. Rapid adaptation with RAMP decreased pH, but no performance differences were observed between long and rapid RAMP adaptation programs. Therefore, cattle started on RAMP do not require extensive adaptation before feeding a finishing diet with Sweet Bran.

Mixed Linear/Square-Root Encoded Single Slope Ramp Provides a Fast, Low Noise Analog to Digital Converter with Very High Linearity for Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Wrigley, Christopher James (Inventor); Hancock, Bruce R. (Inventor); Cunningham, Thomas J. (Inventor); Newton, Kenneth W. (Inventor)

2014-01-01

An analog-to-digital converter (ADC) converts pixel voltages from a CMOS image into a digital output. A voltage ramp generator generates a voltage ramp that has a linear first portion and a non-linear second portion. A digital output generator generates a digital output based on the voltage ramp, the pixel voltages, and comparator output from an array of comparators that compare the voltage ramp to the pixel voltages. A return lookup table linearizes the digital output values.

Financing mechanisms for capital improvements : interchanges : final report.

DOT National Transportation Integrated Search

2010-03-01

This report examines the use of alternative local financing mechanisms for interchange and interchange area infrastructure improvements. The financing mechanisms covered include transportation impact fees, tax increment financing, value capture finan...

Effects of geometric characteristics of interchanges on truck safety

DOT National Transportation Integrated Search

1999-01-18

Relationships between truck accidents and selected geometric characteristics of interchanges are examined. Datasets containing information on truck accident at interchanges, traffic exposure and selected geometric characteristics are analyzed with an...

Safety analysis of interchanges

DOT National Transportation Integrated Search

2007-06-01

The objectives of this research are to synthesize the current state of knowledge concerning the safety assessment of new or modified interchanges; develop a spreadsheet-based computational tool for performing safety assessments of interchanges; and i...

Financing mechanisms for capital improvements : interchanges, final report, March 2010.

DOT National Transportation Integrated Search

2010-03-01

This report examines the use of alternative local financing mechanisms for interchange and interchange area infrastructure improvements. The financing mechanisms covered include transportation impact fees, tax increment financing, value capture finan...

Diverging diamond interchange performance evaluation (I-44 and Route 13)

DOT National Transportation Integrated Search

2011-02-01

Performance evaluation was conducted on the first diverging diamond interchange (DDI) or double : crossover interchange (DCD) constructed in the United States. This evaluation assessed traffic operations, safety and : public perceptions t...

Launch of a Vehicle from a Ramp

ERIC Educational Resources Information Center

Cross, Rod

2011-01-01

A vehicle proceeding up an inclined ramp will become airborne if the ramp comes to a sudden end and if the vehicle fails to stop before it reaches the end of the ramp. A vehicle may also become airborne if it passes over the top of a hill at sufficient speed. In both cases, the vehicle becomes airborne if the point of support underneath the…

29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

Code of Federal Regulations, 2014 CFR

2014-07-01

..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

Code of Federal Regulations, 2012 CFR

2012-07-01

..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.

PubMed

Sekiguchi, Toshio; Kuwasako, Kenji; Ogasawara, Michio; Takahashi, Hiroki; Matsubara, Shin; Osugi, Tomohiro; Muramatsu, Ikunobu; Sasayama, Yuichi; Suzuki, Nobuo; Satake, Honoo

2016-01-29

The calcitonin (CT)/CT gene-related peptide (CGRP) family is conserved in vertebrates. The activities of this peptide family are regulated by a combination of two receptors, namely the calcitonin receptor (CTR) and the CTR-like receptor (CLR), and three receptor activity-modifying proteins (RAMPs). Furthermore, RAMPs act as escort proteins by translocating CLR to the cell membrane. Recently, CT/CGRP family peptides have been identified or inferred in several invertebrates. However, the molecular characteristics and relevant functions of the CTR/CLR and RAMPs in invertebrates remain unclear. In this study, we identified three CT/CGRP family peptides (Bf-CTFPs), one CTR/CLR-like receptor (Bf-CTFP-R), and three RAMP-like proteins (Bf-RAMP-LPs) in the basal chordate amphioxus (Branchiostoma floridae). The Bf-CTFPs were shown to possess an N-terminal circular region typical of the CT/CGRP family and a C-terminal Pro-NH2. The Bf-CTFP genes were expressed in the central nervous system and in endocrine cells of the midgut, indicating that Bf-CTFPs serve as brain and/or gut peptides. Cell surface expression of the Bf-CTFP-R was enhanced by co-expression with each Bf-RAMP-LP. Furthermore, Bf-CTFPs activated Bf-CTFP-R·Bf-RAMP-LP complexes, resulting in cAMP accumulation. These results confirmed that Bf-RAMP-LPs, like vertebrate RAMPs, are prerequisites for the function and translocation of the Bf-CTFP-R. The relative potencies of the three peptides at each receptor were similar. Bf-CTFP2 was a potent ligand at all receptors in cAMP assays. Bf-RAMP-LP effects on ligand potency order were distinct to vertebrate CGRP/adrenomedullin/amylin receptors. To the best of our knowledge, this is the first molecular and functional characterization of an authentic invertebrate CT/CGRP family receptor and RAMPs. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Possibilities of fish passage through the block ramp: Model-based estimation of permeability.

PubMed

Plesiński, Karol; Bylak, Aneta; Radecki-Pawlik, Artur; Mikołajczyk, Tomasz; Kukuła, Krzysztof

2018-08-01

Block ramps offer an opportunity to combine hydrotechnical structures with fish passages. The primary study objective was to evaluate the effectiveness of a block ramp for upstream fish movement in a mountain stream. Geodetic measurements of the bottom surface and water level were taken for three cross-sections. The description of the geometric and hydrodynamic parameters of the block ramp was supplemented with information on the width and length of crevices between boulders. Measurements of the geometric and hydrodynamic parameters of the block ramp were performed at 76 measurement sites, at three different types of discharge. Ichthyological data were collected in the analyzed stream. Measurements covered among others total length, width, and height of caught fish. Salmonid, cottid, balitorid, and cyprinid fish were studied. The determination of the main effects of the geometric and hydrodynamic parameters of the block ramp on the possibilities of use by target fish species employed generalized linear models (GLMs). The study shows that the block ramp cannot provide longitudinal connectivity and migration of fish occurring in the mountain stream. According to estimates, the block ramp did not meet the permeability expectations. The reason for low usefulness of the ramp for fish is particularly excessively strong water current. The stream concentration constituted an unsurmountable velocity barrier for fish moving upstream for each of the analyzed discharges. The developed model suggests that some crevices in the side zones of the ramp could be parts of the migration corridor, but only for small and medium-sized fish. At medium and high water stages, movement of fish in crevices was difficult due to fast water current, and at low and very low discharges, some crevices lost their permeability, and could become ecological traps for fish. The necessity of estimation of ramp permeability during pre-construction phase was emphasized. Copyright © 2018 Elsevier B.V. All rights reserved.

Freeway ramp management in Pennsylvania.

DOT National Transportation Integrated Search

2011-03-31

This research identified the opportunities to implement ramp management strategies on freeways in Pennsylvania. The research : explored the need to integrate local arterial traffic signal systems with ramp management strategies to reduce the impacts ...

Lateral ramps in the folded Appalachians and in overthrust belts worldwide; a fundamental element of thrust-belt architecture

USGS Publications Warehouse

Pohn, Howard A.

2000-01-01

Lateral ramps are zones where decollements change stratigraphic level along strike; they differ from frontal ramps, which are zones where decollements change stratigraphic level perpendicular to strike. In the Appalachian Mountains, the surface criteria for recognizing the subsurface presence of lateral ramps include (1) an abrupt change in wavelength or a termination of folds along strike, (2) a conspicuous change in the frequency of mapped faults or disturbed zones (extremely disrupted duplexes) at the surface, (3) long, straight river trends emerging onto the coastal plain or into the Appalachian Plateaus province, (4) major geomorphic discontinuities in the trend of the Blue Ridge province, (5) interruption of Mesozoic basins by cross-strike border faults, and (6) zones of modern and probable ancient seismic activity. Additional features related to lateral ramps include tectonic windows, cross-strike igneous intrusions, areas of giant landslides, and abrupt changes in Paleozoic sedimentation along strike. Proprietary strike-line seismic-reflection profiles cross three of the lateral ramps that were identified by using the surface criteria. The profiles confirm their presence and show their detailed nature in the subsurface. Like frontal ramps, lateral ramps are one of two possible consequences of fold-and-thrust-belt tectonics and are common elements in the Appalachian fold-and-thrust belt. A survey of other thrust belts in the United States and elsewhere strongly suggests that lateral ramps at depth can be identified by their surface effects. Lateral ramps probably are the result of thrust sheet motion caused by continued activation of ancient cratonic fracture systems. Such fractures localized the transform faults along which the continental segments adjusted during episodes of sea-floor spreading.

Study on Trailing Edge Ramp of Supercritical Airfoil

DTIC Science & Technology

2016-03-30

7 th Asia-Pacific International Symposium on Aerospace Technology, 25 – 27 November 2015, Cairns Study on Trailing Edge Ramp of Supercritical...China Abstract Trailing edge flow control method could improve the performance of supercritical airfoil with a small modification on the original...airfoil. In this paper, a ramp of 2%~7% chord length is sliced near the trailing edge to improve airfoil performance. The trailing edge ramp is

Wind-Friendly Flexible Ramping Product Design in Multi-Timescale Power System Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Mingjian; Zhang, Jie; Wu, Hongyu

With increasing wind power penetration in the electricity grid, system operators are recognizing the need for additional flexibility, and some are implementing new ramping products as a type of ancillary service. However, wind is generally thought of as causing the need for ramping services, not as being a potential source for the service. In this paper, a multi-timescale unit commitment and economic dispatch model is developed to consider the wind power ramping product (WPRP). An optimized swinging door algorithm with dynamic programming is applied to identify and forecast wind power ramps (WPRs). Designed as positive characteristics of WPRs, the WPRPmore » is then integrated into the multi-timescale dispatch model that considers new objective functions, ramping capacity limits, active power limits, and flexible ramping requirements. Numerical simulations on the modified IEEE 118-bus system show the potential effectiveness of WPRP in increasing the economic efficiency of power system operations with high levels of wind power penetration. It is found that WPRP not only reduces the production cost by using less ramping reserves scheduled by conventional generators, but also possibly enhances the reliability of power system operations. Moreover, wind power forecasts play an important role in providing high-quality WPRP service.« less

Driver Expectations When Navigating Complex Interchanges

DOT National Transportation Integrated Search

2013-10-01

The purpose of this project was to develop a method for determining driver expectations at interchanges and to use that method to determine how these expectations affect driver behavior at interchanges that vary in level of complexity, including prov...

Ramp meter design manual

DOT National Transportation Integrated Search

2000-01-01

Caltrans is committed to using ramp metering as an effective traffic management strategy to maintain an efficient freeway system and protect the investment made in constructing freeways by keeping them operating at or near capacity. Ramp Metering is ...

Uncertainty-based Estimation of the Secure Range for ISO New England Dynamic Interchange Adjustment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Etingov, Pavel V.; Makarov, Yuri V.; Wu, Di

2014-04-14

The paper proposes an approach to estimate the secure range for dynamic interchange adjustment, which assists system operators in scheduling the interchange with neighboring control areas. Uncertainties associated with various sources are incorporated. The proposed method is implemented in the dynamic interchange adjustment (DINA) tool developed by Pacific Northwest National Laboratory (PNNL) for ISO New England. Simulation results are used to validate the effectiveness of the proposed method.

Issues in formulary management: therapeutic interchange. The value, cost, and quality of therapeutic interchange.

PubMed

Mahoney, C D

1992-10-01

Therapeutic interchange is a process of substituting a prescribed medication with one that offers therapeutic and cost benefits. The practice not only provides short-term savings but also is associated with decreases in lengths of stay in hospitals and total hospital drug expenses. There may be medicolegal implications when FDA-approved indications differ for interchanged drugs. The potential for liability is decreased when a standard of care is met, but since standards can change, guidelines should be reviewed regularly. High-tech, high-cost drugs are sometimes appropriate for therapeutic interchange. Pharmacy and therapeutics committees should assure best value by considering indirect expenses, quality, and therapeutic outcome, as well as product cost. Therapeutic interchange programs enable pharmacy managers to neutralize or at least slow the rate of drug cost increases, ensuring appropriate utilization of resources and more favorable patient outcomes.

A tunable electron beam source using trapping of electrons in a density down-ramp in laser wakefield acceleration.

PubMed

Ekerfelt, Henrik; Hansson, Martin; Gallardo González, Isabel; Davoine, Xavier; Lundh, Olle

2017-09-25

One challenge in the development of laser wakefield accelerators is to demonstrate sufficient control and reproducibility of the parameters of the generated bunches of accelerated electrons. Here we report on a numerical study, where we demonstrate that trapping using density down-ramps allows for tuning of several electron bunch parameters by varying the properties of the density down-ramp. We show that the electron bunch length is determined by the difference in density before and after the ramp. Furthermore, the transverse emittance of the bunch is controlled by the steepness of the ramp. Finally, the amount of trapped charge depends both on the density difference and on the steepness of the ramp. We emphasize that both parameters of the density ramp are feasible to vary experimentally. We therefore conclude that this tunable electron accelerator makes it suitable for a wide range of applications, from those requiring short pulse length and low emittance, such as the free-electron lasers, to those requiring high-charge, large-emittance bunches to maximize betatron X-ray generation.

Flow control of micro-ramps on supersonic forward-facing step flow

NASA Astrophysics Data System (ADS)

Qing-Hu, Zhang; Tao, Zhu; Shihe, Yi; Anping, Wu

2016-05-01

The effects of the micro-ramps on supersonic turbulent flow over a forward-facing step (FFS) was experimentally investigated in a supersonic low-noise wind tunnel at Mach number 3 using nano-tracer planar laser scattering (NPLS) and particle image velocimetry (PIV) techniques. High spatiotemporal resolution images and velocity fields of supersonic flow over the testing model were captured. The fine structures and their spatial evolutionary characteristics without and with the micro-ramps were revealed and compared. The large-scale structures generated by the micro-ramps can survive the downstream FFS flowfield. The micro-ramps control on the flow separation and the separation shock unsteadiness was investigated by PIV results. With the micro-ramps, the reduction in the range of the reversal flow zone in streamwise direction is 50% and the turbulence intensity is also reduced. Moreover, the reduction in the average separated region and in separation shock unsteadiness are 47% and 26%, respectively. The results indicate that the micro-ramps are effective in reducing the flow separation and the separation shock unsteadiness. Project supported by the National Natural Science Foundation of China (Grant Nos. 11172326 and 11502280).

Development of performance matrices for evaluating innovative intersections and interchanges.

DOT National Transportation Integrated Search

2015-09-01

Innovative intersections and interchanges, primarily Continuous Flow Intersection (CFI) and Diverging Diamond : Interchange (DDI), have seen an increase in numbers in the State of Utah over the past several years, making Utah a : leader in the countr...

Relationship Factors Contributing to the Progression of Combat Related PTSD and Suicidality over Time

DTIC Science & Technology

2014-04-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The RAMP project is designed to examine the key social context of intimate romantic...report is the “Relationships Among Military Personnel (RAMP) Project”. The RAMP project is designed to examine the key social context of intimate...making the RAMP Facebook page accessible (https://www.facebook.com/TheRAMPProject. As of March 1, 2014, 1531 individuals completed the eligibility

Interchange mode excited by trapped energetic ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nishimura, Seiya, E-mail: n-seiya@kobe-kosen.ac.jp

2015-07-15

The kinetic energy principle describing the interaction between ideal magnetohydrodynamic (MHD) modes with trapped energetic ions is revised. A model is proposed on the basis of the reduced ideal MHD equations for background plasmas and the bounce-averaged drift-kinetic equation for trapped energetic ions. The model is applicable to large-aspect-ratio toroidal devices. Specifically, the effect of trapped energetic ions on the interchange mode in helical systems is analyzed. Results show that the interchange mode is excited by trapped energetic ions, even if the equilibrium states are stable to the ideal interchange mode. The energetic-ion-induced branch of the interchange mode might bemore » associated with the fishbone mode in helical systems.« less

Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension.

PubMed

Figueira, Leticia; Israel, Anita

2017-02-01

Adrenomedullin (AM) and its receptors components, calcitonin-receptor-like receptor (CRLR), and receptor activity-modifying protein (RAMP1, RAMP2, and RAMP3) are expressed in cerebellum. Cerebellar AM, AM binding sites and receptor components are altered during hypertension, suggesting a role for cerebellar AM in blood pressure regulation. Thus, we assessed the effect of valsartan, on AM and its receptor components expression in the cerebellar vermis of Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Additionally, we evaluated AM action on superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activity, and thiobarbituric acid reactive substances (TBARS) production in cerebellar vermis. Animals were treated with valsartan or vehicle for 11 days. Rats were sacrificed by decapitation; cerebellar vermis was dissected; and AM, CRLR, RAMP1, RAMP2, and RAMP3 expression was quantified by Western blot analysis. CAT, SOD, and GPx activity was determined spectrophotometrically and blood pressure by non-invasive plethysmography. We demonstrate that AM and RAMP2 expression was lower in cerebellum of SHR rats, while CRLR, RAMP1, and RAMP3 expression was higher than those of WKY rats. AM reduced cerebellar CAT, SOD, GPx activities, and TBARS production in WKY rats, but not in SHR rats. Valsartan reduced blood pressure and reversed the altered expression of AM and its receptors components, as well the loss of AM capacity to reduce antioxidant enzyme activity and TBARS production in SHR rats. These findings demonstrate that valsartan is able to reverse the dysregulation of cerebellar adrenomedullinergic system; and they suggest that altered AM system in the cerebellum could represent the primary abnormality leading to hypertension.

78 FR 17431 - Antitrust Division

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-21

... Production Act of 1993--Interchangeable Virtual Instruments Foundation, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), Interchangeable Virtual Instruments Foundation, Inc. has filed... in this group research project remains open, and Interchangeable Virtual Instruments Foundation, Inc...

48 CFR 227.676 - Foreign patent interchange agreements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Foreign patent interchange... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Foreign License and Technical Assistance Agreements 227.676 Foreign patent interchange agreements. (a) Patent...

48 CFR 227.676 - Foreign patent interchange agreements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Foreign patent interchange... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Foreign License and Technical Assistance Agreements 227.676 Foreign patent interchange agreements. (a) Patent...

48 CFR 227.676 - Foreign patent interchange agreements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Foreign patent interchange... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Foreign License and Technical Assistance Agreements 227.676 Foreign patent interchange agreements. (a) Patent...

48 CFR 227.676 - Foreign patent interchange agreements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Foreign patent interchange... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Foreign License and Technical Assistance Agreements 227.676 Foreign patent interchange agreements. (a) Patent...

48 CFR 227.676 - Foreign patent interchange agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Foreign patent interchange... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Foreign License and Technical Assistance Agreements 227.676 Foreign patent interchange agreements. (a) Patent...

Twin Cities ramp meter evaluation : executive summary

DOT National Transportation Integrated Search

2001-02-01

This report details the results of a study on the traffic flow and safety impacts of ramp metering. The study served two important public purposes. 1. It thoroughly documented the benefits resulting from ramp metering to traffic operations and relate...

Developing an area-wide system for coordinated ramp meter control.

DOT National Transportation Integrated Search

2008-12-01

Ramp metering has been broadly accepted and deployed as an effective countermeasure : against both recurrent and non-recurrent congestion on freeways. However, many current ramp : metering algorithms tend to improve only freeway travels using local d...

Facility No. S362, view across the ramp U.S. Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Facility No. S362, view across the ramp - U.S. Naval Base, Pearl Harbor, Seaplane Ramps - World War II Type, Southwest and west shore of Ford Island, near Wasp Boulevard, Pearl City, Honolulu County, HI

Congestion-Responsive On-Ramp Metering : Before and After Studies - Phase 1

DOT National Transportation Integrated Search

2016-07-06

The objective of this project was to develop recommendations toward a statewide policy of congestion responsive freeway ramp metering operation. The research is performed in two phases. In phase 1, alternative ramp metering activation strategies were...

Assessing the Effectiveness of Ramp-Up During Sonar Operations Using Exposure Models.

PubMed

von Benda-Beckmann, Alexander M; Wensveen, Paul J; Kvadsheim, Petter H; Lam, Frans-Peter A; Miller, Patrick J O; Tyack, Peter L; Ainslie, Michael A

2016-01-01

Ramp-up procedures are used to mitigate the impact of sound on marine mammals. Sound exposure models combined with observations of marine mammals responding to sound can be used to assess the effectiveness of ramp-up procedures. We found that ramp-up procedures before full-level sonar operations can reduce the risk of hearing threshold shifts with marine mammals, but their effectiveness depends strongly on the responsiveness of the animals. In this paper, we investigated the effect of sonar parameters (source level, pulse-repetition time, ship speed) on sound exposure by using a simple analytical model and highlight the mechanisms that limit the effectiveness of ramp-up procedures.

Improving short-term forecasting during ramp events by means of Regime-Switching Artificial Neural Networks

NASA Astrophysics Data System (ADS)

Gallego, C.; Costa, A.; Cuerva, A.

2010-09-01

Since nowadays wind energy can't be neither scheduled nor large-scale storaged, wind power forecasting has been useful to minimize the impact of wind fluctuations. In particular, short-term forecasting (characterised by prediction horizons from minutes to a few days) is currently required by energy producers (in a daily electricity market context) and the TSO's (in order to keep the stability/balance of an electrical system). Within the short-term background, time-series based models (i.e., statistical models) have shown a better performance than NWP models for horizons up to few hours. These models try to learn and replicate the dynamic shown by the time series of a certain variable. When considering the power output of wind farms, ramp events are usually observed, being characterized by a large positive gradient in the time series (ramp-up) or negative (ramp-down) during relatively short time periods (few hours). Ramp events may be motivated by many different causes, involving generally several spatial scales, since the large scale (fronts, low pressure systems) up to the local scale (wind turbine shut-down due to high wind speed, yaw misalignment due to fast changes of wind direction). Hence, the output power may show unexpected dynamics during ramp events depending on the underlying processes; consequently, traditional statistical models considering only one dynamic for the hole power time series may be inappropriate. This work proposes a Regime Switching (RS) model based on Artificial Neural Nets (ANN). The RS-ANN model gathers as many ANN's as different dynamics considered (called regimes); a certain ANN is selected so as to predict the output power, depending on the current regime. The current regime is on-line updated based on a gradient criteria, regarding the past two values of the output power. 3 Regimes are established, concerning ramp events: ramp-up, ramp-down and no-ramp regime. In order to assess the skillness of the proposed RS-ANN model, a single-ANN model (without regime classification) is adopted as a reference model. Both models are evaluated in terms of Improvement over Persistence on the Mean Square Error basis (IoP%) when predicting horizons form 1 time-step to 5. The case of a wind farm located in the complex terrain of Alaiz (north of Spain) has been considered. Three years of available power output data with a hourly resolution have been employed: two years for training and validation of the model and the last year for assessing the accuracy. Results showed that the RS-ANN overcame the single-ANN model for one step-ahead forecasts: the overall IoP% was up to 8.66% for the RS-ANN model (depending on the gradient criterion selected to consider the ramp regime triggered) and 6.16% for the single-ANN. However, both models showed similar accuracy for larger horizons. A locally-weighted evaluation during ramp events for one-step ahead was also performed. It was found that the IoP% during ramps-up increased from 17.60% (case of single-ANN) to 22.25% (case of RS-ANN); however, during the ramps-down events this improvement increased from 18.55% to 19.55%. Three main conclusions are derived from this case study: It highlights the importance of considering statistical models capable of differentiate several regimes showed by the output power time series in order to improve the forecasting during extreme events like ramps. On-line regime classification based on available power output data didn't seem to contribute to improve forecasts for horizons beyond one-step ahead. Tacking into account other explanatory variables (local wind measurements, NWP outputs) could lead to a better understanding of ramp events, improving the regime assessment also for further horizons. The RS-ANN model slightly overcame the single-ANN during ramp-down events. If further research reinforce this effect, special attention should be addressed to understand the underlying processes during ramp-down events.

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.

PubMed

Cegla, Jaimini; Jones, Ben J; Gardiner, James V; Hodson, David J; Marjot, Thomas; McGlone, Emma R; Tan, Tricia M; Bloom, Stephen R

2017-08-01

Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon causes weight loss by reducing food intake and increasing energy expenditure. To further understand the cellular mechanisms by which glucagon and related ligands activate the glucagon receptor (GCGR), we investigated the interaction of the GCGR with receptor activity modifying protein (RAMP)2, a member of the family of receptor activity modifying proteins. We used a combination of competition binding experiments, cell surface enzyme-linked immunosorbent assay, functional assays assessing the Gαs and Gαq pathways and β-arrestin recruitment, and small interfering RNA knockdown to examine the effect of RAMP2 on the GCGR. Ligands tested were glucagon; glucagonlike peptide-1 (GLP-1); oxyntomodulin; and analog G(X), a GLP-1/glucagon coagonist developed in-house. Confocal microscopy was used to assess whether RAMP2 affects the subcellular distribution of GCGR. Here we demonstrate that coexpression of RAMP2 and the GCGR results in reduced cell surface expression of the GCGR. This was confirmed by confocal microscopy, which demonstrated that RAMP2 colocalizes with the GCGR and causes significant GCGR cellular redistribution. Furthermore, the presence of RAMP2 influences signaling through the Gαs and Gαq pathways, as well as recruitment of β-arrestin. This work suggests that RAMP2 may modify the agonist activity and trafficking of the GCGR, with potential relevance to production of new peptide analogs with selective agonist activities.

2. AERIAL VIEW OF INTERCHANGE OF ARROYO SECO PARKWAY AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. AERIAL VIEW OF INTERCHANGE OF ARROYO SECO PARKWAY AND INTERSTATE I-5 INTERCHANGE. NOTE ARROYO SECO DRAINAGE INTO LOS ANGELES RIVER AT BOTTOM CENTER. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

Missouri's experience with a diverging diamond interchange : lessons learned.

DOT National Transportation Integrated Search

2010-05-01

The first DDI in the nation opened to traffic on June 21, 2009, in Springfield, Missouri. The interchange in : Springfield where the Kansas Expressway (MO-13) passes over I-44 is a huge success. A diverging diamond : interchange (DDI), sometimes refe...

Twin Cities ramp meter evaluation : evaluation plan

DOT National Transportation Integrated Search

2000-09-25

The Minnesota Department of Transportation (Mn/DOT) uses ramp meters to manage freeway access on approximately 210 miles of freeways in the Twin Cities metropolitan area. Mn/DOT first tested ramp meters in 1969 as a method to optimize freeway safety ...

16. Built c. 1936, this ramp from the first to ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Built c. 1936, this ramp from the first to the second floor along the northwestern side of Pier G (shown at the first floor) was called 'ramp C.' - Lehigh Valley Railroad, Pier G, Jersey City, Hudson County, NJ

Statistical Analysis of Interchange Injection Events from Over a Decade of Cassini Data

NASA Astrophysics Data System (ADS)

Azari, A.; Jia, X.; Liemohn, M. W.; Sergis, N.; Thomsen, M. F.; Mitchell, D. G.; Rymer, A. M.; Paranicas, C.; Provan, G.; Ye, S.; Cowley, S. W. H.; Hospodarsky, G. B.; Vandegriff, J. D.; Kurth, W. S.

2017-12-01

The Cassini spacecraft has routinely observed interchange injection events with multiple instruments since arriving at Saturn in 2004. Interchange injection events are thought to initiate from a Rayleigh-Taylor like plasma instability sourced from Saturn's rapid rotation (period 10.8 hours) and dense plasma population outgassing primarily from Enceladus, and are the primary source of mass transport in the inner/middle magnetosphere. This dense plasma must be transported outward, and to conserve magnetic flux, inward moving flux tubes of low density, energetic (> keV) plasma from the outer reaches of the Saturnian system also occur. These inward-bound flux tubes are referred to as interchange injections. We will present a statistical evaluation of the occurrence rates of interchange injections at Saturn demonstrating seasonal dependence of interchange over the entirety of the Cassini mission's equatorial orbits between 2005 and 2016. We identify interchange events from CHarge Energy Mass Spectrometer (CHEMS) H+ data using a trained and tested automated algorithm. Our event identification compares well with manual identification and previous surveys of injections by L-shell and local time (Chen and Hill, 2008, Lai et al., 2016, Kennelly et al., 2013). We find that peak rates of interchange events occur between 7 - 9 Saturn radii, in agreement with previous surveys. We also evaluate interchange by preferred local time sector and season, splitting our events into pre-equinox, equinox, and post - equinox time periods. We determine that over all seasons, nightside occurrence dominated as compared to dayside, but the preferred dayside sector shifts from pre-noon during equinox, to post-noon during post-equinox. We will further investigate seasonal dependence by presenting occurrence organized by the phase systems derived based on Saturn kilometric radiation (SKR) and magnetic field perturbations (PPO).

Examining Relay Ramp Evolution Through Paleo-shoreline Deformation Analysis, Warner Valley Fault, Oregon

NASA Astrophysics Data System (ADS)

Young, C. S.; Dawers, N. H.

2017-12-01

Fault growth is often accomplished by linking a series of en echelon faults through relay ramps. A relay ramp is the area between two overlapping fault segments that tilts and deforms as the faults accrue displacement. The structural evolution of breached normal fault relay ramps remains poorly understood because of the difficulty in defining how slip is partitioned between the most basinward fault (known as the outboard fault), the overlapping fault (inboard fault), and any ramp-breaching linking faults. Along the Warner Valley fault in south-central Oregon, two relay ramps displaying different fault linkage geometries are lined with a series of paleo-lacustrine shorelines that record a Pleistocene paleolake regression. The inner edges of these shorelines act as paleo-horizontal datums that have been deformed by fault activity, and are used to measure relative slip variations across the relay ramp bounding faults. By measuring the elevation changes using a 10m digital elevation model (DEM) of shoreline inner edges, we estimate the amount of slip partitioned between the inboard, outboard and ramp-breaching linking faults. In order to attribute shoreline deformation to fault activity we identify shoreline elevation anomalies, where deformation exceeds a ± 3.34 m window, which encompass our conservative estimates of natural variability in the shoreline geomorphology and the error associated with the data collection. Fault activity along the main length of the fault for each ramp-breaching style is concentrated near the intersection of the linking fault and the outboard portion of the main fault segment. However, fault activity along the outboard fault tip varies according to breaching style. At a footwall breach the entire outboard fault tip appears relatively inactive. At a mid-ramp breach the outboard fault tip remains relatively active because of the proximity of the linking fault to this fault tip.

Wind Energy Management System Integration Project Incorporating Wind Generation and Load Forecast Uncertainties into Power Grid Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarov, Yuri V.; Huang, Zhenyu; Etingov, Pavel V.

2010-09-01

The power system balancing process, which includes the scheduling, real time dispatch (load following) and regulation processes, is traditionally based on deterministic models. Since the conventional generation needs time to be committed and dispatched to a desired megawatt level, the scheduling and load following processes use load and wind power production forecasts to achieve future balance between the conventional generation and energy storage on the one side, and system load, intermittent resources (such as wind and solar generation) and scheduled interchange on the other side. Although in real life the forecasting procedures imply some uncertainty around the load and windmore » forecasts (caused by forecast errors), only their mean values are actually used in the generation dispatch and commitment procedures. Since the actual load and intermittent generation can deviate from their forecasts, it becomes increasingly unclear (especially, with the increasing penetration of renewable resources) whether the system would be actually able to meet the conventional generation requirements within the look-ahead horizon, what the additional balancing efforts would be needed as we get closer to the real time, and what additional costs would be incurred by those needs. In order to improve the system control performance characteristics, maintain system reliability, and minimize expenses related to the system balancing functions, it becomes necessary to incorporate the predicted uncertainty ranges into the scheduling, load following, and, in some extent, into the regulation processes. It is also important to address the uncertainty problem comprehensively, by including all sources of uncertainty (load, intermittent generation, generators’ forced outages, etc.) into consideration. All aspects of uncertainty such as the imbalance size (which is the same as capacity needed to mitigate the imbalance) and generation ramping requirement must be taken into account. The latter unique features make this work a significant step forward toward the objective of incorporating of wind, solar, load, and other uncertainties into power system operations. In this report, a new methodology to predict the uncertainty ranges for the required balancing capacity, ramping capability and ramp duration is presented. Uncertainties created by system load forecast errors, wind and solar forecast errors, generation forced outages are taken into account. The uncertainty ranges are evaluated for different confidence levels of having the actual generation requirements within the corresponding limits. The methodology helps to identify system balancing reserve requirement based on a desired system performance levels, identify system “breaking points”, where the generation system becomes unable to follow the generation requirement curve with the user-specified probability level, and determine the time remaining to these potential events. The approach includes three stages: statistical and actual data acquisition, statistical analysis of retrospective information, and prediction of future grid balancing requirements for specified time horizons and confidence intervals. Assessment of the capacity and ramping requirements is performed using a specially developed probabilistic algorithm based on a histogram analysis incorporating all sources of uncertainty and parameters of a continuous (wind forecast and load forecast errors) and discrete (forced generator outages and failures to start up) nature. Preliminary simulations using California Independent System Operator (California ISO) real life data have shown the effectiveness of the proposed approach. A tool developed based on the new methodology described in this report will be integrated with the California ISO systems. Contractual work is currently in place to integrate the tool with the AREVA EMS system.« less

The ability of laying pullets to negotiate two ramp designs as measured by bird preference and behaviour

PubMed Central

Weeks, Claire A.; Norman, Kate I.; Nicol, Christine J.

2017-01-01

Background Laying hens are often kept in barn or free-range systems where they must negotiate level changes in the house to access resources. However, collisions and resultant keel fractures are commonplace. Producers sometimes add ramps to make raised areas more accessible but designs vary and very little research has investigated bird preference or behaviour when using different ramp designs, or the effect of ramp design on falls and collisions. Methods Two ramp designs were studied in an experimental setting—a ramp made of plastic poultry slats (grid ramp, GR) and a ramp made of wooden rungs (ladder ramp, LR). Sixty-four young female hens were trained to move to a food reward and this was used to test their behavioural responses when first negotiating the two different ramps during individual tests. Both upward and downward transitions were studied. Ramp preference was also tested using a room that replicated a commercial single-tier system with both types of ramp available. Birds were placed in this room in groups of 16 for three days and their use of the ramps studied. Results A greater percentage of birds successfully completed (reached the reward bowl) on the GR than the LR during both upward (58% vs 37%) and downward (83% vs 73%) transitions, and a smaller percentage of birds made zero attempts to use the GR than the LR (upwards: 13% vs 56%, downwards: 8% vs 26%). When making a downward transition, more hesitation behaviours were seen (head orientations, stepping on the spot, moving away) for the LR. However, more head orientations were seen for the GR during the upward transition. Birds were more likely to abort attempts (an attempt began when a bird placed both feet on the ramp) to move up the GR than the LR. Birds took longer to negotiate the LR than the GR in both directions, and more pauses were seen during a successful upward transition on the LR. Birds were more likely to move down the GR by walking/running whereas birds tended to jump over the entire LR. More collisions with the food reward bowl were seen for the LR. In the group tests, birds preferred to use the GR, with more transitions seen at all timepoints. However, in these tests, birds preferred to rest on the LR with greater numbers of birds counted on this type of ramp during scan sampling at all timepoints. Discussion Behavioural results suggest that the GR was easier for the birds to use than the LR, particularly on the downward transition. The GR was also less likely to result in collisions. However, the upward transition may be more difficult on the GR for some birds, potentially because of the inability to pause on a level surface during the transition. The results suggest that the GR was preferred by pullets for moving between a raised area and the ground but the LR was preferred for resting. PMID:29177116

Evaluation of alternative intersections and interchanges: volume 2 -- diverging diamond interchange signal timing.

DOT National Transportation Integrated Search

2015-12-01

This report presents findings from field studies of operations at diverging diamond interchanges (DDIs) in Salt Lake City, Utah and Fort : Wayne, Indiana. These discuss optimization of signal offsets both within the DDI, and with the DDI integrated a...

Comparison of the operational and safety characteristics of the single point urban and diamond interchanges.

DOT National Transportation Integrated Search

1996-01-01

The purpose of this study was to evaluate and compare the safety and operational characteristics of the single point urban interchange (SPUI) and the diamond interchange (DI) and develop guidelines that identify traffic and/or geometric conditions th...

What Kind of International Interchange Is Beneficial? Experiences of Taiwanese Indigenes

ERIC Educational Resources Information Center

Chen, Shan-Hua

2014-01-01

Because of globalization, international interchanges among indigenes in every country have become more frequent. Influenced by international multicultural trends, Taiwan's government not only supports indigenous populations to revive their traditional cultures, but also encourages the promotion of the international interchange activities among…

The effect of diagrammatic signing at head speed interchanges; final report, by Frank D. Shepard.

DOT National Transportation Integrated Search

1974-01-01

Improvements in highway guide signing at interchange areas are needed to reduce driver confusion and the accidents that result from it. One possible means of improving traffic operations within interchange areas is through the use of diagrammatic sig...

Guidelines for Evaluation of Ramp Signaling Deployments in a Real-Time Operations Environment

DOT National Transportation Integrated Search

2017-12-01

State agencies have developed warrants and guidelines for the identification of on-ramps for metering. However, these warrants only consider recurrent traffic conditions in the vicinity of each on-ramp without considering the need to meter multiple r...

Ramp metering : a review of the literature.

DOT National Transportation Integrated Search

1998-01-01

Ramp metering is an effective, viable, and practical strategy used to manage freeway traffic. It is a proven freeway management technique as various forms of ramp control have been in place since the 1960s in the Chicago, Detroit, and Los Angeles are...

Aerial view looking northwest showing location of seaplane ramps 2,3, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Aerial view looking northwest showing location of seaplane ramps 2,3, and 4. Ramps lead from buildings 1 and 2, bayside left center, into San Diego Bay. - Naval Air Station North Island, North Island, San Diego, San Diego County, CA

Measuring the effectiveness of ramp metering strategies on I-12 : [tech summary].

DOT National Transportation Integrated Search

2013-10-01

In recent years, more emphasis has been placed on Active Traffi c Management (ATM) strategies such as speed harmonization, managed lanes, and : ramp metering. Ramp metering is one of the successful active traffi c control strategies, controlling the ...

Aeroelastic Response and Protection of Space Shuttle External Tank Cable Trays

NASA Technical Reports Server (NTRS)

Edwards, John W.; Keller, Donald F.; Schuster, David M.; Piatak, David J.; Rausch, Russ D.; Bartels, Robert E.; Ivanco, Thomas G.; Cole, Stanley R.; Spain, Charles V.

2005-01-01

Sections of the Space Shuttle External Tank Liquid Oxygen (LO2) and Liquid Hydrogen (LH2) cable trays are shielded from potentially damaging airloads with foam Protuberance Aerodynamic Load (PAL) Ramps. Flight standard design LO2 and LH2 cable tray sections were tested with and without PAL Ramp models in the United States Air Force Arnold Engineering Development Center s (AEDC) 16T transonic wind tunnel to obtain experimental data on the aeroelastic stability and response characteristics of the trays and as part of the larger effort to determine whether the PAL ramps can be safely modified or removed. Computational Fluid Dynamic simulations of the full-stack shuttle launch configuration were used to investigate the flow characeristics around and under the cable trays without the protective PAL ramps and to define maximum crossflow Mach numbers and dynamic pressures experienced during launch. These crossflow conditions were used to establish wind tunnel test conditions which also included conservative margins. For all of the conditions and configurations tested, no aeroelastic instabilities or unacceptable dynamic response levels were encountered and no visible structural damage was experienced by any of the tested cable tray sections. Based upon this aeroelastic characterization test, three potentially acceptable alternatives are available for the LO2 cable tray PAL Ramps: Mini-Ramps, Tray Fences, or No Ramps. All configurations were tested to maximum conditions, except the LH2 trays at -15 deg. crossflow angle. This exception is the only caveat preventing the proposal of acceptable alternative configurations for the LH2 trays as well. Structural assessment of all tray loads and tray response measurements from launches following the Shuttle Return To Flight with the existing PAL Ramps will determine the acceptability of these PAL Ramp alternatives.

5 CFR 214.204 - Interchange agreements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Interchange agreements. 214.204 Section... EXECUTIVE SERVICE General Provisions § 214.204 Interchange agreements. (a) In accordance with 5 CFR 6.7, OPM... Service (SES) may, pursuant to legislative and regulatory authorities, enter into an agreement providing...

5 CFR 214.204 - Interchange agreements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Interchange agreements. 214.204 Section... EXECUTIVE SERVICE General Provisions § 214.204 Interchange agreements. (a) In accordance with 5 CFR 6.7, OPM... Service (SES) may, pursuant to legislative and regulatory authorities, enter into an agreement providing...

Measuring the effectiveness of ramp metering strategies on I-12.

DOT National Transportation Integrated Search

2013-10-01

Ramp metering is one of the successful traffic control strategies in the area of active traffic and demand management. This study evaluates the : effectiveness of a fixed time ramp metering control on the day to day operation of traffic over two segm...

Application of multi-objective nonlinear optimization technique for coordinated ramp-metering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haj Salem, Habib; Farhi, Nadir; Lebacque, Jean Patrick, E-mail: abib.haj-salem@ifsttar.fr, E-mail: nadir.frahi@ifsttar.fr, E-mail: jean-patrick.lebacque@ifsttar.fr

2015-03-10

This paper aims at developing a multi-objective nonlinear optimization algorithm applied to coordinated motorway ramp metering. The multi-objective function includes two components: traffic and safety. Off-line simulation studies were performed on A4 France Motorway including 4 on-ramps.

Modelling decremental ramps using 2- and 3-parameter "critical power" models.

PubMed

Morton, R Hugh; Billat, Veronique

2013-01-01

The "Critical Power" (CP) model of human bioenergetics provides a valuable way to identify both limits of tolerance to exercise and mechanisms that underpin that tolerance. It applies principally to cycling-based exercise, but with suitable adjustments for analogous units it can be applied to other exercise modalities; in particular to incremental ramp exercise. It has not yet been applied to decremental ramps which put heavy early demand on the anaerobic energy supply system. This paper details cycling-based bioenergetics of decremental ramps using 2- and 3-parameter CP models. It derives equations that, for an individual of known CP model parameters, define those combinations of starting intensity and decremental gradient which will or will not lead to exhaustion before ramping to zero; and equations that predict time to exhaustion on those decremental ramps that will. These are further detailed with suitably chosen numerical and graphical illustrations. These equations can be used for parameter estimation from collected data, or to make predictions when parameters are known.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenkranz, Joshua-Benedict; Brancucci Martinez-Anido, Carlo; Hodge, Bri-Mathias

Solar power generation, unlike conventional forms of electricity generation, has higher variability and uncertainty in its output because solar plant output is strongly impacted by weather. As the penetration rate of solar capacity increases, grid operators are increasingly concerned about accommodating the increased variability and uncertainty that solar power provides. This paper illustrates the impacts of increasing solar power penetration on the ramping of conventional electricity generators by simulating the operation of the Independent System Operator -- New England power system. A production cost model was used to simulate the power system under five different scenarios, one without solar powermore » and four with increasing solar power penetrations up to 18%, in terms of annual energy. The impact of solar power is analyzed on six different temporal intervals, including hourly and multi-hourly (2- to 6-hour) ramping. The results show how the integration of solar power increases the 1- to 6-hour ramping events of the net load (electric load minus solar power). The study also analyzes the impact of solar power on the distribution of multi-hourly ramping events of fossil-fueled generators and shows increasing 1- to 6-hour ramping events for all different generators. Generators with higher ramp rates such as gas and oil turbine and internal combustion engine generators increased their ramping events by 200% to 280%. For other generator types--including gas combined-cycle generators, coal steam turbine generators, and gas and oil steam turbine generators--more and higher ramping events occurred as well for higher solar power penetration levels.« less

77 FR 66165 - Information Required in Notices and Petitions Containing Interchange Commitments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-02

... information. Furthermore, parties objecting to a petition for exemption or those filing a petition to revoke... future interchange with a third-party connecting carrier, whether by outright prohibition, per-car... involves a provision or agreement that may limit future interchange with a third-party connecting carrier...

Siskiyou summit negative grade arrester bed for runaway trucks : final report.

DOT National Transportation Integrated Search

1986-01-01

Most escape ramps are designed to use gravity as the primary deceleration mechanism. These ramps provide an exit from the roadway to an adjacent hillside, ascending at grades of up to 40%. Loose gravel is often used on these ramps which, while aiding...

Integrated database and analysis system for the evaluation of freeway corridors for potential ramp signaling.

DOT National Transportation Integrated Search

2011-11-15

Ramp signaling is a relatively low-cost traffic management strategy that aims to improve the flow of : traffic by controlling the rate at which vehicles enter the freeway. While studies have shown that ramp : signaling helps to alleviate traffic cong...

Structure function analysis of two-scale Scalar Ramps. Part I: Theory and Modeling

USDA-ARS?s Scientific Manuscript database

Structure functions are used to study the dissipation and inertial range scales of turbulent energy, to parameterize remote turbulence measurements, and to characterize ramp features in the turbulent field. The ramp features are associated with turbulent coherent structures, which dominate energy an...

Interchangeability of gas detection tubes and hand pumps.

PubMed

Haag, W R

2001-01-01

Users of gas detection tubes occasionally seek the convenience of using a single hand pump with different brands of tubes, to avoid the need to carry more than one pump. Several professional organizations recommend against such interchange. However, these recommendations appear to be based on a single study of pump designs that mostly are no longer in use. The present study was undertaken to determine if current hand pumps are interchangeable. Both piston-type and bellows-type hand pumps were evaluated by comparing pump flow profiles and test gas measurements with a variety of tubes. The results demonstrate that three piston hand pumps in common use (Sensidyne/Gastec GV/100, RAE Systems LP-1200, and Matheson-Kitagawa 8104-400A) are fully interchangeable. Two bellows pumps (Draeger Accuro and MSA Kwik-Draw) also are interchangeable with each other. Mixing of bellows and piston systems is often possible, but there are enough exceptions to conclude that such practice should be discouraged because it can give inaccurate readings. It is recommended that technical standards be adopted, such as total volume and an initial pump vacuum or a pump flow curve, to assess hand pump interchangeability. When two manufacturers' pumps meet the same standard and routine leak tests are conducted, interchangeability is scientifically valid and poses no risk to the end user while offering greater convenience.

An efficient algorithm for sorting by block-interchanges and its application to the evolution of vibrio species.

PubMed

Lin, Ying Chih; Lu, Chin Lung; Chang, Hwan-You; Tang, Chuan Yi

2005-01-01

In the study of genome rearrangement, the block-interchanges have been proposed recently as a new kind of global rearrangement events affecting a genome by swapping two nonintersecting segments of any length. The so-called block-interchange distance problem, which is equivalent to the sorting-by-block-interchange problem, is to find a minimum series of block-interchanges for transforming one chromosome into another. In this paper, we study this problem by considering the circular chromosomes and propose a Omicron(deltan) time algorithm for solving it by making use of permutation groups in algebra, where n is the length of the circular chromosome and delta is the minimum number of block-interchanges required for the transformation, which can be calculated in Omicron(n) time in advance. Moreover, we obtain analogous results by extending our algorithm to linear chromosomes. Finally, we have implemented our algorithm and applied it to the circular genomic sequences of three human vibrio pathogens for predicting their evolutionary relationships. Consequently, our experimental results coincide with the previous ones obtained by others using a different comparative genomics approach, which implies that the block-interchange events seem to play a significant role in the evolution of vibrio species.

Exploration of the SHRP2 naturalistic driving study data to identify factors related to the selection of freeway ramp design speed.

DOT National Transportation Integrated Search

2017-03-01

This research explored the second Strategic Highway Research Program (SHRP2) Naturalistic Driving Study (NDS) database for the potential to identify freeway entrance and exit ramps and teen drivers behavior while traveling those ramps. This is in ...

Using archived ITS data to measure the operational benefits of a system-wide adaptive ramp metering system.

DOT National Transportation Integrated Search

2008-12-01

A System-Wide Adaptive Ramp Metering (SWARM) system has been implemented in the Portland, Oregon metropolitan area, replacing the previous pre-timed ramp-metering system that had been in operation since 1981. SWARM has been deployed on six major corr...

Development of criteria and guidelines for installing, operating, and removing TxDOT ramp control signals.

DOT National Transportation Integrated Search

2009-05-01

The Texas Department of Transportation (TxDOT) uses ramp control signals (also called ramp meters or : flow signals) to control the rate at which vehicles enter the freeway. This helps TxDOT (1) promote a more : consistent and uniform flow of traffic...

Portable and Lightweight Ramp Structure

DTIC Science & Technology

2001-04-09

long side of which is in abutting relationship with the 12 short side of the end of the ramp. Fastener receivers are equi- 13 spaced in duplicate...The modular sections are conveniently prefabricated 18 1 and provided in kit form to the number of sections corresponding 2 to the desired ramp

Structure function analysis of two-scale Scalar Ramps. Part II: Coherent structure scaling and surface renewal applications

USDA-ARS?s Scientific Manuscript database

Structure functions are used to study the dissipation and inertial range scales of turbulent energy, to parameterize remote turbulence measurements, and to characterize ramp features in the turbulent field. The ramp features are associated with turbulent coherent structures, which dominate energy a...

Pathfinder Rear Ramp

NASA Image and Video Library

1997-07-06

NASA's Mars Pathfinder's rear rover ramp can be seen successfully unfurled in this image, taken at the end of Sol 2 by the Imager for Mars Pathfinder (IMP). This ramp was later used for the deployment of the microrover Sojourner, which occurred at the end of Sol 2. Areas of a lander petal and deflated airbag are visible at left. The image helped Pathfinder scientists determine that the rear ramp was the one to use for rover deployment. At upper right is the rock dubbed "Barnacle Bill," which Sojourner will later study. http://photojournal.jpl.nasa.gov/catalog/PIA00627

Wind Power Ramping Product for Increasing Power System Flexibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Mingjian; Zhang, Jie; Wu, Hongyu

With increasing penetrations of wind power, system operators are concerned about a potential lack of system flexibility and ramping capacity in real-time dispatch stages. In this paper, a modified dispatch formulation is proposed considering the wind power ramping product (WPRP). A swinging door algorithm (SDA) and dynamic programming are combined and used to detect WPRPs in the next scheduling periods. The detected WPRPs are included in the unit commitment (UC) formulation considering ramping capacity limits, active power limits, and flexible ramping requirements. The modified formulation is solved by mixed integer linear programming. Numerical simulations on a modified PJM 5-bus Systemmore » show the effectiveness of the model considering WPRP, which not only reduces the production cost but also does not affect the generation schedules of thermal units.« less

A polyhedral study of production ramping

DOE PAGES

Damci-Kurt, Pelin; Kucukyavuz, Simge; Rajan, Deepak; ...

2015-06-12

Here, we give strong formulations of ramping constraints—used to model the maximum change in production level for a generator or machine from one time period to the next—and production limits. For the two-period case, we give a complete description of the convex hull of the feasible solutions. The two-period inequalities can be readily used to strengthen ramping formulations without the need for separation. For the general case, we define exponential classes of multi-period variable upper bound and multi-period ramping inequalities, and give conditions under which these inequalities define facets of ramping polyhedra. Finally, we present exact polynomial separation algorithms formore » the inequalities and report computational experiments on using them in a branch-and-cut algorithm to solve unit commitment problems in power generation.« less

Evolution of plasma wakes in density up- and down-ramps

NASA Astrophysics Data System (ADS)

Zhang, C. J.; Joshi, C.; Xu, X. L.; Mori, W. B.; Li, F.; Wan, Y.; Hua, J. F.; Pai, C. H.; Wang, J.; Lu, W.

2018-02-01

The time evolution of plasma wakes in density up- and down-ramps is examined through theory and particle-in-cell simulations. Motivated by observation of the reversal of a linear plasma wake in a plasma density upramp in a recent experiment (Zhang et al 2017 Phys. Rev. Lett. 119 064801) we have examined the behaviour of wakes in plasma ramps that always accompany any plasma source used for plasma-based acceleration. In the up-ramp case it is found that, after the passage of the drive pulse, the wavnumber/wavelength of the wake starts to decrease/increase with time until it eventually tends to zero/infinity, then the wake reverses its propagation direction and the wavenunber/wavelength of the wake begins to increase/shrink. The evolutions of the wavenumber and the phase velocity of the wake as functions of time are shown to be significantly different in the up-ramp and the down-ramp cases. In the latter case the wavenumber of the wake at a particular position in the ramp increases until the wake is eventually damped. It is also shown that the waveform of the wake at a particular time after being excited can be precisely controlled by tuning the initial plasma density profile, which may enable a new type of plasma-based ultrafast optics.

TRANSP-based Trajectory Optimization of the Current Profile Evolution to Facilitate Robust Non-inductive Ramp-up in NSTX-U

NASA Astrophysics Data System (ADS)

Wehner, William; Schuster, Eugenio; Poli, Francesca

2016-10-01

Initial progress towards the design of non-inductive current ramp-up scenarios in the National Spherical Torus Experiment Upgrade (NSTX-U) has been made through the use of TRANSP predictive simulations. The strategy involves, first, ramping the plasma current with high harmonic fast waves (HHFW) to about 400 kA, and then further ramping to 900 kA with neutral beam injection (NBI). However, the early ramping of neutral beams and application of HHFW leads to an undesirably peaked current profile making the plasma unstable to ballooning modes. We present an optimization-based control approach to improve on the non-inductive ramp-up strategy. We combine the TRANSP code with an optimization algorithm based on sequential quadratic programming to search for time evolutions of the NBI powers, the HHFW powers, and the line averaged density that define an open-loop actuator strategy that maximizes the non-inductive current while satisfying constraints associated with the current profile evolution for MHD stable plasmas. This technique has the potential of playing a critical role in achieving robustly stable non-inductive ramp-up, which will ultimately be necessary to demonstrate applicability of the spherical torus concept to larger devices without sufficient room for a central coil. Supported by the US DOE under the SCGSR Program.

Anatomy of a cyclically packaged Mesoproterozoic carbonate ramp in northern Canada

NASA Astrophysics Data System (ADS)

Sherman, A. G.; Narbonne, G. M.; James, N. P.

2001-03-01

Carbonates in the upper member of the Mesoproterozoic Victor Bay Formation are dominated by lime mud and packaged in cycles of 20-50 m. These thicknesses exceed those of classic shallowing-upward cycles by almost a factor of 10. Stratigraphic and sedimentological evidence suggests high-amplitude, high-frequency glacio-eustatic cyclicity, and thus a cool global climate ca. 1.2 Ga. The Victor Bay ramp is one of several late Proterozoic carbonate platforms where the proportions of lime mud, carbonate grains, and microbialites are more typical of younger Phanerozoic successions which followed the global waning of stromatolites. Facies distribution in the study area is compatible with deposition on a low-energy, microtidal, distally steepened ramp. Outer-ramp facies are hemipelagic lime mudstone, shale, carbonaceous rhythmite, and debrites. Mid-ramp facies are molar-tooth limestone tempestite with microspar-intraclast lags. In a marine environment where stromatolitic and oolitic facies were otherwise rare, large stromatolitic reefs developed at the mid-ramp, coeval with inner-ramp facies of microspar grainstone, intertidal dolomitic microbial laminite, and supratidal evaporitic red shale. Deep-subtidal, outer-ramp cycles occur in the southwestern part of the study area. Black dolomitic shale at the base is overlain by ribbon, nodular, and carbonaceous carbonate facies, all of which exhibit signs of synsedimentary disruption. Cycles in the northeast are shallow-subtidal and peritidal in character. Shallow-subtidal cycles consist of basal deep-water facies, and an upper layer of subtidal molar-tooth limestone tempestite interbedded with microspar calcarenite facies. Peritidal cycles are identical to shallow-subtidal cycles except that they contain a cap of dolomitic tidal-flat microbial laminite, and rarely of red shale sabkha facies or of sandy polymictic conglomerate. A transect along the wall of a valley extending 8.5 km perpendicular to depositional strike reveals progradation of inner-ramp tidal flats over outer- and mid-ramp facies during shoaling. The maximum basinward progradation of peritidal facies coincides with a zone of slope failure that may have promoted the development of the stromatolitic reefs. The sea-level history of the Victor Bay Formation is represented by three hectometre-scale sequences. An initial flooding event resulted in deposition of the lower Victor Bay shale member. Upper-member carbonate cycles were then deposited during highstand. Mid-ramp slumping was followed by late-highstand reef development. The second sequence began with development of an inner-ramp lowstand unconformity and a thick mid-ramp lowstand wedge. A second transgression promoted a more modest phase of reef development at the mid-ramp and shallow-water deposition continued inboard. A third and final transgressive episode eventually led to flooding of the backstepping ramp. Overall consistent cycle thickness and absence of truncated cycles, as well as the high rate and amount of creation of accommodation space, suggest that the periodicity and amplitude of sea-level fluctuation were relatively uniform, and point to a eustatic rather than tectonic mechanism of relative sea-level change. High-amplitude, high-frequency eustatic sea-level change is characteristic of icehouse worlds in which short-term, large-scale sea-level fluctuations accompany rapidly changing ice volumes affected by Milankovitch orbital forcing. Packaging of cyclic Upper Victor Bay carbonates therefore supports the hypothesis of a late Mesoproterozoic glacial period, as proposed by previous workers.

Focus on Health and Safety in Child Care: MCH Program Interchange.

ERIC Educational Resources Information Center

National Center for Education in Maternal and Child Health, Washington, DC.

The Maternal Child Health Program Interchange series is intended to promote the cooperative exchange of information about program ideas, activities, and materials. This issue of the Interchange provides information about selected materials and publications related to the health and safety of infants and young children in child care settings. The…

Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.

PubMed

Hill, Heather E; Pioszak, Augen A

2013-03-01

Adrenomedullin (AM) is a peptide hormone that is a potent vasodilator and is essential for vascular development. The AM receptor is a heterodimeric cell surface receptor composed of the calcitonin receptor-like receptor (CLR), a class B G protein-coupled receptor, in association with either of two receptor activity modifying protein (RAMP) coreceptors, RAMP2 or -3. The extracellular domains (ECDs) of CLR and the RAMPs form the primary AM binding site. Here, we present novel methodology for expression and purification of a heterodimeric AM receptor ECD complex as an MBP-CLR ECD fusion protein in association with the RAMP2 ECD. Co-expression of the RAMP2 ECD with the disulfide bond isomerase DsbC in the oxidizing cytoplasm of E. coli trxB gor enabled proper disulfide formation in vivo. The isolated RAMP2 ECD was purified to homogeneity. Co-expression of a soluble MBP-CLR ECD fusion protein with DsbC in E. coli trxB gor yielded a heterogeneous mixture of species with misfolded ECD. Incubation of affinity-purified MBP-CLR ECD in vitro with purified RAMP2 ECD, DsbC, and glutathione redox buffer promoted proper folding of the CLR ECD and formation of a stable MBP-CLR ECD:RAMP2 ECD complex that was purified by size-exclusion chromatography and which exhibited specific AM binding. Approximately 40mg of highly purified complex was obtained starting with 6L bacterial cultures for each protein. The methodology reported here will facilitate structure/function studies of the AM receptor. Copyright © 2012 Elsevier Inc. All rights reserved.

Increased cardiac output elicits higher V̇O2max in response to self-paced exercise.

PubMed

Astorino, Todd Anthony; McMillan, David William; Edmunds, Ross Montgomery; Sanchez, Eduardo

2015-03-01

Recently, a self-paced protocol demonstrated higher maximal oxygen uptake versus the traditional ramp protocol. The primary aim of the current study was to further explore potential differences in maximal oxygen uptake between the ramp and self-paced protocols using simultaneous measurement of cardiac output. Active men and women of various fitness levels (N = 30, mean age = 26.0 ± 5.0 years) completed 3 graded exercise tests separated by a minimum of 48 h. Participants initially completed progressive ramp exercise to exhaustion to determine maximal oxygen uptake followed by a verification test to confirm maximal oxygen uptake attainment. Over the next 2 sessions, they performed a self-paced and an additional ramp protocol. During exercise, gas exchange data were obtained using indirect calorimetry, and thoracic impedance was utilized to estimate hemodynamic function (stroke volume and cardiac output). One-way ANOVA with repeated measures was used to determine differences in maximal oxygen uptake and cardiac output between ramp and self-paced testing. Results demonstrated lower (p < 0.001) maximal oxygen uptake via the ramp (47.2 ± 10.2 mL·kg(-1)·min(-1)) versus the self-paced (50.2 ± 9.6 mL·kg(-1)·min(-1)) protocol, with no interaction (p = 0.06) seen for fitness level. Maximal heart rate and cardiac output (p = 0.02) were higher in the self-paced protocol versus ramp exercise. In conclusion, data show that the traditional ramp protocol may underestimate maximal oxygen uptake compared with a newly developed self-paced protocol, with a greater cardiac output potentially responsible for this outcome.

Therapeutic effect of polysaccharide fraction of Atractylodis macrocephalae Koidz. in bovine subclinical mastitis.

PubMed

Xu, Wei; Guan, Ran; Lu, Yisong; Su, Xiaoyan; Xu, Ye; Du, Aifang; Hu, Songhua

2015-07-25

Mastitis is considered the most significant and persistent disease in dairy cows, bringing about large economic losses. Subclinical mastitis brings about major cost implications, for it is difficult to detect due to absence of any visible indications and can persist in the mammary tissue throughout lactation. Immunomodulators have been widely used to reduce intramammary infections by modulating bovine mammary gland. Atractylodis macrocephalae Koidz. polysaccharides (RAMP), extracted from herbal medicine, has been used widely especially for its immunomodulatory function for many years. The objective of this study was to estimate an oil emulsified Atractylodis macrocephalae Koidz. polysaccharides (RAMP-O) as a potential therapeutic agent to treat subclinical mastitis by subcutaneous injection of RAMP-O in the area of supramammary lymph node in lactating cows via analysis of SCC, IMIs and NAGase. Injection of RAMP-O in the area of supramammary lymph node significantly reduced milk SCC and NAGase activity compared with control. The quarters with bacterial infection were also progressively reduced in RAMP-O treated cows and only 9 quarters were found to have bacterial infection, while no obvious change was found in the control group. Subcutaneous injection of RAMP-O in the area of supramammary lymph node had therapeutic value in the treatment of bovine subclinical mastitis by reducing SCC, NAGase and IMIs in milk. Considering both the therapeutic effect and the cost of RAMP-O, 32 mg per dose was found most suitable to reduce milk SCC and NAGase. Therefore, RAMP-O deserves further study for its use in treatment of bovine mastitis.

The immune adjuvant response of polysaccharides from Atractylodis macrocephalae Koidz in chickens vaccinated against Newcastle disease (ND).

PubMed

Zhao, Xiaona; Sun, Wenjing; Zhang, Shijie; Meng, Guangju; Qi, Chunhua; Fan, Wentao; Wang, Yuge; Liu, Jianzhu

2016-05-05

Build on our previous research, polysaccharides from the rhizome of Atractylodis macrocephalae Koidz (RAMPS), RAMPStp and RAMPS60c were prepared and the structural characterization and immune response of ND vaccine in chicken were investigated. Immune organ index, Lymphocyte proliferation, antibody titers, cell cycle distribution, and percentages of CD4(+) and CD8(+) cells were determined. GPC analysis showed that the Mn of RAMPS with two peaks were 1.29×10(5) and 1.74×10(3), respectively. GC-MS analysis revealed that RAMPS was composed of glucose, mannose, arabinose, galactose, xylose, d-Ribose and rhamnose, with mass percentages of 66.39%, 21.24%, 5.64%, 2.65%, 2.30%, 1.15% and 0.64%, respectively. NMR spectroscopic analysis demonstrated that a preliminary structure of RAMPS was proposed as 1,3-linked β-d-Galp and 1,6-linked β-d-Galpresidues. In vivo test showed that RAMPStp and RAMPS60c could promote peripheral lymphocytes proliferation and entering into S and G2/M phases, enhance serum HI antibody titer and effectively improve the percentages of CD4(+) and CD8(+) T cells in chickens vaccinated with ND vaccine at most time points. The actions of RAMPStp and RAMPS60c were stronger than that of Lev, and RAMPStp presented the best efficacy. These results indicated that RAMPStp and RAMPS60c characterize of the immune-enhancing activity and RAMPStp possessed the strongest activity. It would be anticipated as a component of new-type immunopotentiator. Copyright © 2016 Elsevier Ltd. All rights reserved.

Magnetic curvature effects on plasma interchange turbulence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, B., E-mail: bli@pku.edu.cn; Liao, X.; Sun, C. K.

2016-06-15

The magnetic curvature effects on plasma interchange turbulence and transport in the Z-pinch and dipole-like systems are explored with two-fluid global simulations. By comparing the transport levels in the systems with a different magnetic curvature, we show that the interchange-mode driven transport strongly depends on the magnetic geometry. For the system with large magnetic curvature, the pressure and density profiles are strongly peaked in a marginally stable state and the nonlinear evolution of interchange modes produces the global convective cells in the azimuthal direction, which lead to the low level of turbulent convective transport.

14. VIEW OF THE MODERN CONCRETE RAMP THAT CONNECTED THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. VIEW OF THE MODERN CONCRETE RAMP THAT CONNECTED THE UPPER AND LOWER MINE ROADS. TRUCKS USED THIS RAMP AND THE ROADS TO HAUL SLAG TO THE MINE DUMP. - Tower Hill No. 2 Mine, Approximately 0.47 mile Southwest of intersection of Stone Church Road & Township Route 561, Hibbs, Fayette County, PA

36 CFR 1192.81 - Lighting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Vehicles and Systems § 1192.81 Lighting. (a) Any stepwell or doorway with a lift, ramp or bridge plate... measured on the step tread or lift platform. (b) Other stepwells, and doorways with lifts, ramps or bridge... lift or ramp, when deployed at the vehicle floor level. (c) The doorways of vehicles not operating at...

36 CFR 1192.81 - Lighting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Vehicles and Systems § 1192.81 Lighting. (a) Any stepwell or doorway with a lift, ramp or bridge plate... measured on the step tread or lift platform. (b) Other stepwells, and doorways with lifts, ramps or bridge... lift or ramp, when deployed at the vehicle floor level. (c) The doorways of vehicles not operating at...

Third Expert Consultation on RAMP (RAMP III) (Helsinki, Finland, September 13, 15 and 20, 1986). Final Report.

ERIC Educational Resources Information Center

United Nations Educational, Scientific and Cultural Organization, Paris (France). General Information Programme.

Organized for the United Nations Educational, Scientific, and Cultural Organization (Unesco) by contract with the International Council on Archives (ICA), this meeting concerning the Records and Archives Management Programme (RAMP) was attended by 14 experts invited from Unesco member countries. Following a brief introduction, summaries are…

Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Booe, Jason M.; Walker, Christopher S.; Barwell, James

Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind relatedmore » GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. Lastly, the structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.« less

Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor

DOE PAGES

Booe, Jason M.; Walker, Christopher S.; Barwell, James; ...

2015-05-14

Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind relatedmore » GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. Lastly, the structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.« less

Evaluation and enhancement of Texas ramp metering strategies, compliance, and alternative enforcement techniques: Go with the flow Houston. Public outreach plan (revised); Interim research report, September 1995--October 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lancaster, S.; Fette, B.; Busler, L.

This report describes the public outreach plan on the implementation of ramp meters along the Katy Freeway in Houston, Generally, ramp metering is neither beloved nor understood by the public. To gain public awareness, acceptance, compliance and continued support, ramp metering operations should be reinforced by a strong, ongoing public information and outreach campaign that communicates the need for and benefits of the program. Because the term `ramp metering` exhibits restrictions on the public, the phrase `Flow Signals` was developed to better describe the benefits of ramp metering; enhanced flow of traffic, fewer bottlenecks, and fewer trip delays. The logo,more » `Go with the Flow Houston,` and a graphic identity were developed to help communicate the theme throughout the various media where both the primary and secondary messages are intended to reach 15 different audiences. These media will include: a PSA, both static and changeable message signs, a brochure, Internet web site information, letters to specific audience and media relations efforts.« less

A Copula-Based Conditional Probabilistic Forecast Model for Wind Power Ramps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, Brian S; Krishnan, Venkat K; Zhang, Jie

Efficient management of wind ramping characteristics can significantly reduce wind integration costs for balancing authorities. By considering the stochastic dependence of wind power ramp (WPR) features, this paper develops a conditional probabilistic wind power ramp forecast (cp-WPRF) model based on Copula theory. The WPRs dataset is constructed by extracting ramps from a large dataset of historical wind power. Each WPR feature (e.g., rate, magnitude, duration, and start-time) is separately forecasted by considering the coupling effects among different ramp features. To accurately model the marginal distributions with a copula, a Gaussian mixture model (GMM) is adopted to characterize the WPR uncertaintymore » and features. The Canonical Maximum Likelihood (CML) method is used to estimate parameters of the multivariable copula. The optimal copula model is chosen based on the Bayesian information criterion (BIC) from each copula family. Finally, the best conditions based cp-WPRF model is determined by predictive interval (PI) based evaluation metrics. Numerical simulations on publicly available wind power data show that the developed copula-based cp-WPRF model can predict WPRs with a high level of reliability and sharpness.« less

Color Mosaic of Rover & Terrain

NASA Image and Video Library

1997-07-05

NASA's Sojourner rover and undeployed ramps onboard the Mars Pathfinder spacecraft can be seen in this image, by the Imager for Mars Pathfinder (IMP) on July 4 (Sol 1). This image has been corrected for the curvature created by parallax. The microrover Sojourner is latched to the petal, and has not yet been deployed. The ramps are a pair of deployable metal reels which will provide a track for the rover as it slowly rolls off the lander, over the spacecraft's deflated airbags, and onto the surface of Mars. Pathfinder scientists will use this image to determine whether it is safe to deploy the ramps. One or both of the ramps will be unfurled, and then scientists will decide whether the rover will use either the forward or backward ramp for its descent. http://photojournal.jpl.nasa.gov/catalog/PIA00621

High temperature seal for large structural movements

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M. (Inventor); Dunlap, Jr., Patrick H. (Inventor)

2004-01-01

A high temperature sealing system is operative to seal an interface between adjacent hot structures and to minimize parasitic flow between such structures that move relative to one another in-plane or out-of-plane. The sealing system may be used to seal thrust-directing ramp structures of a reusable launch vehicle and includes a channel and a plurality of movable segmented sealing elements. Adjacent ramp structures include edge walls which extend within the channel. The sealing elements are positioned along the sides of the channel and are biased to engage with the inner surfaces of the ramp structures. The segmented sealing elements are movable to correspond to the contour of the thrust-directing ramp structures. The sealing system is operative to prevent high temperature thrust gases that flow along the ramp structures from infiltrating into the interior of the vehicle.

Fully non-inductive second harmonic electron cyclotron plasma ramp-up in the QUEST spherical tokamak

NASA Astrophysics Data System (ADS)

Idei, H.; Kariya, T.; Imai, T.; Mishra, K.; Onchi, T.; Watanabe, O.; Zushi, H.; Hanada, K.; Qian, J.; Ejiri, A.; Alam, M. M.; Nakamura, K.; Fujisawa, A.; Nagashima, Y.; Hasegawa, M.; Matsuoka, K.; Fukuyama, A.; Kubo, S.; Shimozuma, T.; Yoshikawa, M.; Sakamoto, M.; Kawasaki, S.; Nakashima, H.; Higashijima, A.; Ide, S.; Maekawa, T.; Takase, Y.; Toi, K.

2017-12-01

Fully non-inductive second (2nd) harmonic electron cyclotron (EC) plasma current ramp-up was demonstrated with a newlly developed 28 GHz system in the QUEST spherical tokamak. A high plasma current of 54 kA was non-inductively ramped up and sustained stably for 0.9 s with a 270 kW 28 GHz wave. A higher plasma current of 66 kA was also non-inductively achieved with a slow ramp-up of the vertical field. We have achieved a significantly higher plasma current than those achieved previously with the 2nd harmonic EC waves. This fully non-inductive 2nd harmonic EC plasma ramp-up method might be useful for future burning plasma devices and fusion reactors, in particular for operations at half magnetic field with the same EC heating equipment.

Evaluation of the quality of care of a multi-disciplinary Risk Factor Assessment and Management Programme for Hypertension (RAMP-HT).

PubMed

Yu, Esther Yee Tak; Wan, Eric Yuk Fai; Chan, Karina Hiu Yen; Wong, Carlos King Ho; Kwok, Ruby Lai Ping; Fong, Daniel Yee Tak; Lam, Cindy Lo Kuen

2015-06-19

There is some evidence to support a risk-stratified, multi-disciplinary approach to manage patients with hypertension in primary care. The aim of this study is to evaluate the quality of care (QOC) of a multi-disciplinary Risk Assessment and Management Programme for Hypertension (RAMP-HT) for hypertensive patients in busy government-funded primary care clinics in Hong Kong. The objectives are to develop an evidence-based, structured and comprehensive evaluation framework on quality of care, to enhance the QOC of the RAMP-HT through an audit spiral of two evaluation cycles and to determine the effectiveness of the programme in reducing cardiovascular disease (CVD) risk. A longitudinal study is conducted using the Action Learning and Audit Spiral methodologies to measure whether pre-set target standards of care intended by the RAMP-HT are achieved. A structured evaluation framework on the quality of structure, process and outcomes of care has been developed based on the programme objectives and literature review in collaboration with the programme workgroup and health service providers. Each participating clinic is invited to complete a structure of care evaluation questionnaire in each evaluation cycle. The data of all patients who have enrolled into the RAMP-HT in the pre-defined evaluation periods are used for the evaluation of the process and outcomes of care in each evaluation cycle. For evaluation of the effectiveness of RAMP-HT, the primary outcomes including blood pressure (both systolic and diastolic), low-density lipoprotein cholesterol and estimated 10-year CVD risk of RAMP-HT participants are compared to those of hypertensive patients in usual care without RAMP-HT. The QOC and effectiveness of the RAMP-HT in improving clinical and patient-reported outcomes for patients with hypertension in normal primary care will be determined. Possible areas for quality enhancement and standards of good practice will be established to inform service planning and policy decision making.

The Place of Community-Based Learning in Higher Education: A Case Study of Interchange

ERIC Educational Resources Information Center

Hardwick, Louise

2013-01-01

This article focuses on one strand of community engagement: community-based learning for students. It considers in particular Interchange as a case study. Interchange is a registered charity based in, but independent of, a department in a Higher Education Institution. It brokers between undergraduate research/work projects and Voluntary Community…

45 CFR 162.1802 - Standards for coordination of benefits information transaction.

Code of Federal Regulations, 2014 CFR

2014-10-01

....) (ii) The ASC X12 Standards for Electronic Data Interchange Technical Report Type 3—Health Care Claim... X12 Standards for Electronic Date Interchange Technical Report Type 3, October 2007, ASC X12N... Interchange Technical Report Type 3—Health Care Claim: Professional (837), May 2006, ASC X12N/005010X222...

45 CFR 162.1802 - Standards for coordination of benefits information transaction.

Code of Federal Regulations, 2010 CFR

2010-10-01

....) (ii) The ASC X12 Standards for Electronic Data Interchange Technical Report Type 3—Health Care Claim... X12 Standards for Electronic Date Interchange Technical Report Type 3, October 2007, ASC X12N... Interchange Technical Report Type 3—Health Care Claim: Professional (837), May 2006, ASC X12N/005010X222...

45 CFR 162.1102 - Standards for health care claims or equivalent encounter information transaction.

Code of Federal Regulations, 2014 CFR

2014-10-01

....) (ii) Dental health care claims. The ASC X12 Standards for Electronic Data Interchange Technical Report... Care Claim: Dental (837) ASC X12 Standards for Electronic Date Interchange Technical Report Type 3... care claims. The ASC X12 Standards for Electronic Data Interchange Technical Report Type 3—Health Care...

75 FR 27384 - Notice of Final Federal Agency Actions on Proposed Highway in California

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... State Route 99 from the existing four-lane facility to six lanes from the Austin Road interchange in the... California. The State Route 99 Manteca Widening Project would provide congestion relief along a stretch of State Route 99 from the Austin Road interchange to the Arch Road interchange, improve future traffic...

Experimental demonstration of 1535-1555-nm simultaneous optical wavelength interchange with a nonlinear photonic crystal.

PubMed

Chowdhury, A; Staus, C; Boland, B F; Kuech, T F; McCaughan, L

2001-09-01

We present results of what is to our knowledge the first experimental demonstration of simultaneous optical wavelength interchange by use of a two-dimensional second-order nonlinear photonic crystal. Fabrication and performance parameters of a 1535-1555-nm wavelength interchange nonlinear photonic crystal fabricated in lithium niobate are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tucker, Eric; Boreman, Glenn, E-mail: gboreman@uncc.edu; D'Archangel, Jeffrey

Near- and far-field measurements of phase-ramped loop and patch structures are presented and compared to simulations. The far-field deflection measurements show that the phase-ramped structures can deflect a beam away from specular reflection, consistent with simulations. Scattering scanning near-field optical microscopy of the elements comprising the phase ramped structures reveals part of the underlying near-field phase contribution that dictates the far-field deflection, which correlates with the far-field phase behavior that was expected. These measurements provide insight into the resonances, coupling, and spatial phase variation among phase-ramped frequency selective surface (FSS) elements, which are important for the performance of FSS reflectarrays.

RAMP: A fault tolerant distributed microcomputer structure for aircraft navigation and control

NASA Technical Reports Server (NTRS)

Dunn, W. R.

1980-01-01

RAMP consists of distributed sets of parallel computers partioned on the basis of software and packaging constraints. To minimize hardware and software complexity, the processors operate asynchronously. It was shown that through the design of asymptotically stable control laws, data errors due to the asynchronism were minimized. It was further shown that by designing control laws with this property and making minor hardware modifications to the RAMP modules, the system became inherently tolerant to intermittent faults. A laboratory version of RAMP was constructed and is described in the paper along with the experimental results.

Early Observations with the ACS Ramp Filters

NASA Astrophysics Data System (ADS)

Tsvetanov, Z.; Hartig, G.; Bohlin, R.; Tran, H. D.; Martel, A.; Sirianni, M.; Clampin, M.

2002-05-01

The Advanced Camera for Surveys (ACS) on-board the Hubble Space Telescope (HST) is equipped with a set of ramp filters which provide imaging capability at 2% and 9% bandwidth in the range 3700-10700 Å. Each ramp filter consist of three segments where the middle segment can be used with both the Wide Field Channel (WFC) and High Resolution Channel (HRC), while the inner and outer segments can be used only with WFC. The monochromatic field of view is approximately 40'' by 80''. We will present observations of the planetary nebula (PN) NGC6543 (the Cat's Eye) taken with the ACS ramp filetrs in several key emission lines - [O II] 3727, [O III] 5007, H-alpha+[N II], and [S II] 6725. These four emission lines fall onto three separate middle ramp segments - FR388N, FR505N, and FR656N - and will allow inter-comparison between the ACS ramp filters and fixed bandpass narrow-band filters F502N and F658N for both the WFC and HRC detectors. These observations were taken as part of the HST Servicing Mission Orbital Verification program and were designed to test ramp filters performance. We will demostrate our ability to obtain monochromatic (i.e., emission line) images at arbitrary wavelength and recover the surface brightness distribution. This work was supported by a NASA contract and a NASA grant.

Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations.

PubMed

Shin, Jung-Won; Chu, Kon; Jung, Keun-Hwa; Lee, Soon-Tae; Moon, Jangsup; Lee, Sang Kun

2014-12-01

The Food and Drug Administration (FDA) only requires bioequivalence testing of generic substitutions in order for them to be deemed equivalen to the original product. There may be a large difference of bioavailability among the generic drugs that especially have a narrow therapeutic index, and this may affect clinical outcomes. We aimed to determine whether switching from generic-to-generic equivalent anti-epileptic drugs (AEDs) in patients with epilepsy is associated with clinical outcomes. We performed a retrospective study using the electronic medical records of a tertiary hospital. Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80). We compared the drug concentration of phenytoin and seizure events before and after the switch. After switching their generic phenytoin, 33 out of 80 patients (41%) suffered from increasing seizure events (pre-interchange period, 0.44 ± 0.97; post-interchange period, 1.24 ± 2.05; p < 0.0001). The number of medical visits for acute seizure significantly increased in the post-interchange period. The phenytoin serum concentration of all the patients was lesser in the post-interchange period than in the pre-interchange period. (pre-interchange period, 12.79 μg/mL; post-interchange period, 6.36 μg/mL; p < 0.0001). Among the patients with drug resistant epilepsy (DRE), 17 patients (84.2%) had increasing seizure events in the post-interchange period. We confirmed that there was a significant difference in bioavailability between generic phenytoin. Therefore, when using or switching generic anti-epileptic drugs, therapeutic drug monitoring must be done, and the patients' condition must be considered.

40 CFR 1042.505 - Testing engines using discrete-mode or ramped-modal duty cycles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Testing engines using discrete-mode or...-IGNITION ENGINES AND VESSELS Test Procedures § 1042.505 Testing engines using discrete-mode or ramped-modal... the Clean Air Act. (a) You may perform steady-state testing with either discrete-mode or ramped-modal...

40 CFR 1039.505 - How do I test engines using steady-state duty cycles, including ramped-modal testing?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-state duty cycles, including ramped-modal testing? 1039.505 Section 1039.505 Protection of Environment... duty cycles, including ramped-modal testing? This section describes how to test engines under steady-state conditions. In some cases, we allow you to choose the appropriate steady-state duty cycle for an...

Mixed Linear/Square-Root Encoded Single-Slope Ramp Provides Low-Noise ADC with High Linearity for Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Wrigley, Chris J.; Hancock, Bruce R.; Newton, Kenneth W.; Cunningham, Thomas J.

2013-01-01

Single-slope analog-to-digital converters (ADCs) are particularly useful for onchip digitization in focal plane arrays (FPAs) because of their inherent monotonicity, relative simplicity, and efficiency for column-parallel applications, but they are comparatively slow. Squareroot encoding can allow the number of code values to be reduced without loss of signal-to-noise ratio (SNR) by keeping the quantization noise just below the signal shot noise. This encoding can be implemented directly by using a quadratic ramp. The reduction in the number of code values can substantially increase the quantization speed. However, in an FPA, the fixed pattern noise (FPN) limits the use of small quantization steps at low signal levels. If the zero-point is adjusted so that the lowest column is onscale, the other columns, including those at the center of the distribution, will be pushed up the ramp where the quantization noise is higher. Additionally, the finite frequency response of the ramp buffer amplifier and the comparator distort the shape of the ramp, so that the effective ramp value at the time the comparator trips differs from the intended value, resulting in errors. Allowing increased settling time decreases the quantization speed, while increasing the bandwidth increases the noise. The FPN problem is solved by breaking the ramp into two portions, with some fraction of the available code values allocated to a linear ramp and the remainder to a quadratic ramp. To avoid large transients, both the value and the slope of the linear and quadratic portions should be equal where they join. The span of the linear portion must cover the minimum offset, but not necessarily the maximum, since the fraction of the pixels above the upper limit will still be correctly quantized, albeit with increased quantization noise. The required linear span, maximum signal and ratio of quantization noise to shot noise at high signal, along with the continuity requirement, determines the number of code values that must be allocated to each portion. The distortion problem is solved by using a lookup table to convert captured code values back to signal levels. The values in this table will be similar to the intended ramp value, but with a correction for the finite bandwidth effects. Continuous-time comparators are used, and their bandwidth is set below the step rate, which smoothes the ramp and reduces the noise. No settling time is needed, as would be the case for clocked comparators, but the low bandwidth enhances the distortion of the non-linear portion. This is corrected by use of a return lookup table, which differs from the one used to generate the ramp. The return lookup table is obtained by calibrating against a stepped precision DC reference. This results in a residual non-linearity well below the quantization noise. This method can also compensate for differential non-linearity (DNL) in the DAC used to generate the ramp. The use of a ramp with a combination of linear and quadratic portions for a single-slope ADC is novel. The number of steps is minimized by keeping the step size just below the photon shot noise. This in turn maximizes the speed of the conversion. High resolution is maintained by keeping small quantization steps at low signals, and noise is minimized by allowing the lowest analog bandwidth, all without increasing the quantization noise. A calibrated return lookup table allows the system to maintain excellent linearity.

Downscaling Solar Power Output to 4-Seconds for Use in Integration Studies (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hummon, M.; Weekley, A.; Searight, K.

2013-10-01

High penetration renewable integration studies require solar power data with high spatial and temporal accuracy to quantify the impact of high frequency solar power ramps on the operation of the system. Our previous work concentrated on downscaling solar power from one hour to one minute by simulation. This method used clearness classifications to categorize temporal and spatial variability, and iterative methods to simulate intra-hour clearness variability. We determined that solar power ramp correlations between sites decrease with distance and the duration of the ramp, starting at around 0.6 for 30-minute ramps between sites that are less than 20 km apart.more » The sub-hour irradiance algorithm we developed has a noise floor that causes the correlations to approach ~0.005. Below one minute, the majority of the correlations of solar power ramps between sites less than 20 km apart are zero, and thus a new method to simulate intra-minute variability is needed. These intra-minute solar power ramps can be simulated using several methods, three of which we evaluate: a cubic spline fit to the one-minute solar power data; projection of the power spectral density toward the higher frequency domain; and average high frequency power spectral density from measured data. Each of these methods either under- or over-estimates the variability of intra-minute solar power ramps. We show that an optimized weighted linear sum of methods, dependent on the classification of temporal variability of the segment of one-minute solar power data, yields time series and ramp distributions similar to measured high-resolution solar irradiance data.« less

Downscaling Solar Power Output to 4-Seconds for Use in Integration Studies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hummon, M.; Weekley, A.; Searight, K.

2013-10-01

High penetration renewable integration studies require solar power data with high spatial and temporal accuracy to quantify the impact of high frequency solar power ramps on the operation of the system. Our previous work concentrated on downscaling solar power from one hour to one minute by simulation. This method used clearness classifications to categorize temporal and spatial variability, and iterative methods to simulate intra-hour clearness variability. We determined that solar power ramp correlations between sites decrease with distance and the duration of the ramp, starting at around 0.6 for 30-minute ramps between sites that are less than 20 km apart.more » The sub-hour irradiance algorithm we developed has a noise floor that causes the correlations to approach ~0.005. Below one minute, the majority of the correlations of solar power ramps between sites less than 20 km apart are zero, and thus a new method to simulate intra-minute variability is needed. These intra-minute solar power ramps can be simulated using several methods, three of which we evaluate: a cubic spline fit to the one-minute solar power data; projection of the power spectral density toward the higher frequency domain; and average high frequency power spectral density from measured data. Each of these methods either under- or over-estimates the variability of intra-minute solar power ramps. We show that an optimized weighted linear sum of methods, dependent on the classification of temporal variability of the segment of one-minute solar power data, yields time series and ramp distributions similar to measured high-resolution solar irradiance data.« less

LOCALIZATION OF CALCITONIN RECEPTOR-LIKE RECEPTOR (CLR) AND RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 (RAMP1) IN HUMAN GASTROINTESTINAL TRACT

PubMed Central

Cottrell, Graeme S.; Alemi, Farzad; Kirkland, Jacob G.; Grady, Eileen F.; Corvera, Carlos U.; Bhargava, Aditi

2012-01-01

Calcitonin gene-related peptide (CGRP) exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). Despite the importance of CLR•RAMP1 in human disease, little is known about its distribution in the human gastrointestinal (GI) tract, where it participates in inflammation and pain. In this study, we determined that CLR and RAMP1 mRNAs are expressed in normal human stomach, ileum and colon by RT-PCR. We next characterized antibodies that we generated to rat CLR and RAMP1 in transfected HEK cells. Having characterized these antibodies in vitro, we then localized CLR-, RAMP1-, CGRP- and intermedin-immunoreactivity (IMD-IR) in various human GI segments. In the stomach, nerve bundles in the myenteric plexus and nerve fibers throughout the circular and longitudinal muscle had prominent CLR-IR. In the proximal colon and ileum, CLR was found in nerve varicosities of the myenteric plexus and surrounding submucosal neurons. Interestingly, CGRP expressing fibers did not co-localize, but were in close proximity to CLR. However, CLR and RAMP1, the two subunits of a functional CGRP receptor were clearly localized in myenteric plexus, where they may form functional cell-surface receptors. IMD, another member of calcitonin peptide family was also found in close proximity to CLR, and like CGRP, did not co-localize with either CLR or RAMP1 receptors. Thus, CGRP and IMD appear to be released locally, where they can mediate their effect on their receptors regulating diverse functions such as inflammation, pain and motility. PMID:22484227

Traffic dynamics of an on-ramp system with a cellular automaton model

NASA Astrophysics Data System (ADS)

Li, Xin-Gang; Gao, Zi-You; Jia, Bin; Jiang, Rui

2010-06-01

This paper uses the cellular automaton model to study the dynamics of traffic flow around an on-ramp with an acceleration lane. It adopts a parameter, which can reflect different lane-changing behaviour, to represent the diversity of driving behaviour. The refined cellular automaton model is used to describe the lower acceleration rate of a vehicle. The phase diagram and the capacity of the on-ramp system are investigated. The simulation results show that in the single cell model, the capacity of the on-ramp system will stay at the highest flow of a one lane system when the driver is moderate and careful; it will be reduced when the driver is aggressive. In the refined cellular automaton model, the capacity is always reduced even when the driver is careful. It proposes that the capacity drop of the on-ramp system is caused by aggressive lane-changing behaviour and lower acceleration rate.

Fast, precise, and widely tunable frequency control of an optical parametric oscillator referenced to a frequency comb.

PubMed

Prehn, Alexander; Glöckner, Rosa; Rempe, Gerhard; Zeppenfeld, Martin

2017-03-01

Optical frequency combs (OFCs) provide a convenient reference for the frequency stabilization of continuous-wave lasers. We demonstrate a frequency control method relying on tracking over a wide range and stabilizing the beat note between the laser and the OFC. The approach combines fast frequency ramps on a millisecond timescale in the entire mode-hop free tuning range of the laser and precise stabilization to single frequencies. We apply it to a commercially available optical parametric oscillator (OPO) and demonstrate tuning over more than 60 GHz with a ramping speed up to 3 GHz/ms. Frequency ramps spanning 15 GHz are performed in less than 10 ms, with the OPO instantly relocked to the OFC after the ramp at any desired frequency. The developed control hardware and software are able to stabilize the OPO to sub-MHz precision and to perform sequences of fast frequency ramps automatically.

Static internal performance of a single expansion ramp nozzle with multiaxis thrust vectoring capability

NASA Technical Reports Server (NTRS)

Capone, Francis J.; Schirmer, Alberto W.

1993-01-01

An investigation was conducted at static conditions in order to determine the internal performance characteristics of a multiaxis thrust vectoring single expansion ramp nozzle. Yaw vectoring was achieved by deflecting yaw flaps in the nozzle sidewall into the nozzle exhaust flow. In order to eliminate any physical interference between the variable angle yaw flap deflected into the exhaust flow and the nozzle upper ramp and lower flap which were deflected for pitch vectoring, the downstream corners of both the nozzle ramp and lower flap were cut off to allow for up to 30 deg of yaw vectoring. The effects of nozzle upper ramp and lower flap cutout, yaw flap hinge line location and hinge inclination angle, sidewall containment, geometric pitch vector angle, and geometric yaw vector angle were studied. This investigation was conducted in the static-test facility of the Langley 16-Foot Transonic Tunnel at nozzle pressure ratios up to 8.0.

Micro-Ramp Flow Control for Oblique Shock Interactions: Comparisons of Computational and Experimental Data

NASA Technical Reports Server (NTRS)

Hirt, Stefanie M.; Reich, David B.; O'Connor, Michael B.

2010-01-01

Computational fluid dynamics was used to study the effectiveness of micro-ramp vortex generators to control oblique shock boundary layer interactions. Simulations were based on experiments previously conducted in the 15 x 15 cm supersonic wind tunnel at NASA Glenn Research Center. Four micro-ramp geometries were tested at Mach 2.0 varying the height, chord length, and spanwise spacing between micro-ramps. The overall flow field was examined. Additionally, key parameters such as boundary-layer displacement thickness, momentum thickness and incompressible shape factor were also examined. The computational results predicted the effects of the micro-ramps well, including the trends for the impact that the devices had on the shock boundary layer interaction. However, computing the shock boundary layer interaction itself proved to be problematic since the calculations predicted more pronounced adverse effects on the boundary layer due to the shock than were seen in the experiment.

Anomalous current diffusion and improved confinement in the HT-6M tohamak

NASA Astrophysics Data System (ADS)

Gao, X.; Li, J. G.; Wan, Y. X.; Huo, Y. P.; Guo, W. K.; Fan, S. P.; Yu, C. X.; Luo, J. R.; Yin, F. X.; Meng, Y. D.; Zheng, L.; Yin, F.; Lin, B. L.; Zhang, S. Y.; Wang, S. Y.; Lu, H. J.; Liu, S. X.; Tong, X. D.; Ding, L. C.; Wu, Z. Y.; Yin, X. J.; Guo, Q. L.; Gong, X. Z.; Wu, X. C.; Zhao, J. Y.; Xi, J. S.

1994-10-01

Current diffusion was studied during edge ohmic heating (EOH) experiments in the HT-6M tokamak. The EOH power system makes the plasma current linearly ramp up from an initial steady state ( Ip=55kA) to a second steady state ( Ip=60kA) at a fast ramp rate of 12 MA/s. A stable discharge of an improved confinement was observed experimentally in the HT-6M tokamak after the plasma current was ramped to rise rapidly to a second steady state. The plasma current is ramped up much faster than both the classical skin time and neoclassical skin time. Fast current ramp up increases the anomalous current diffusion. The measured values of {β P+l i}/{2} and the soft X-ray sawtooth inversion radius imply the anomalous current penetration. The mechanism of anomalous penetration and improved confinement is discussed.

What Do Kinematic Models Imply About the Constitutive Properties of Rocks Deformed in Flat-Ramp-Flat Folds?

NASA Astrophysics Data System (ADS)

Cruz, L.; Nevitt, J. M.; Seixas, G.; Hilley, G. E.

2017-10-01

Kinematic theories of flat-ramp-flat folds relate fault angles to stratal dips in a way that allows prediction of structural geometries in areas of economic or scientific interest. However, these geometric descriptions imply constitutive properties of rocks that might be discordant with field and laboratory measurements. In this study, we compare deformation resulting from kinematic and mechanical models of flat-ramp-flat folds with identical geometries to determine the conditions over which kinematic models may be reasonably applied to folded rocks. Results show that most mechanical models do not conform to the geometries predicted by the kinematic models, and only low basal friction (μ ≤ 0.1) and shallow ramps (ramp angle ≤10°) produce geometries consistent with kinematic predictions. This implies that the kinematic models might be appropriate for a narrow set of geometric and basal fault friction parameters.

Expression of recombinant antibacterial lactoferricin-related peptides from Pichia pastoris expression system.

PubMed

Chen, Gen-Hung; Chen, Wei-Ming; Huang, Guo-Ting; Chen, Yu-Wen; Jiang, Shann-Tzong

2009-10-28

Four recombinant antimicrobial peptide (rAMP) cDNAs, constructed from two goat lactoferricin-related peptide cDNAs (GLFcin and GLFcin II) with/without (His)(6)-Tag, were cloned into pPICZalphaC and transformed into Pichia pastoris SMD1168H. After methanol induction, these rAMPs were expressed and secreted into broth. They were purified after CM-Sepharose (without His-tg), HisTrap (with His-tg) and Sephadex G-25 chromatographies. The yield of purified rAMP was 0.15 mg/mL of broth. These 4 rAMPs were thermal-stable and with high antibacterial activity against Escherichia coli BCRC 11549, Pseudomonas aeruginosa BCRC 12450, Bacillus cereus BCRC 10603, Staphylococcus aureus BCRC 25923, Propioni bacterium acnes BCRC 10723, and Listera monocytogenes BCRC 14845. The minimum inhibitory concentration (MIC) of rAMPs against these indicators ranged from 4.07 to 16.00 mg/mL.

[The equivalence and interchangeability of medical articles].

PubMed

Antonov, V S

2013-11-01

The information concerning the interchangeability of medical articles is highly valuable because it makes it possible to correlate most precisely medical articles with medical technologies and medical care standards and to optimize budget costs under public purchasing. The proposed procedure of determination of interchangeability is based on criteria of equivalence of prescriptions, functional technical and technological characteristics and effectiveness of functioning of medical articles.

32 CFR 644.408 - Interchange of national forest and military and civil works lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Interchange of national forest and military and... Property and Easement Interests § 644.408 Interchange of national forest and military and civil works lands. 16 U.S.C. 505a, 505b authorizes the Secretary of Agriculture, with respect to national forest lands...

Modernization of Defense Logistics Standard Systems. Establishing the Functional Baseline. Volume 2. Appendix H

DTIC Science & Technology

1991-09-01

and "DD" is the numeric value of the day (01-31). [61 Time ( TM ). The time type is symbolized by the representation " TM ." Format for this type is...VERSION ID M DT 06/06 M TM 04/04 M ID 01/01 M ID 05/05 ISA13 112 ISA14 113 ISA15 114 ISA16 115INTERCHANGE *ACKNOWLEDG. * S1TEST 14 * SUBELEMENT N CTRL...Max - 6 Date of the interchange. DLMS Usage: As above. 109 Interchange Time Type - TM Min - 4 Max - 4 Time of the interchange. DLMS Usage: As above

ePrescribing: Reducing Costs through In-Class Therapeutic Interchange.

PubMed

Stenner, Shane P; Chakravarthy, Rohini; Johnson, Kevin B; Miller, William L; Olson, Julie; Wickizer, Marleen; Johnson, Nate N; Ohmer, Rick; Uskavitch, David R; Bernard, Gordon R; Neal, Erin B; Lehmann, Christoph U

2016-12-14

Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. For all medication classes, significant improvements were demonstrated - the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan - $17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates.

A Magnetohydrodynamic Modeling of the Interchange Cycle for Oblique Northward Interplanetary Magnetic Field

NASA Astrophysics Data System (ADS)

Watanabe, Masakazu; Fujita, Shigeru; Tanaka, Takashi; Kubota, Yasubumi; Shinagawa, Hiroyuki; Murata, Ken T.

2018-01-01

We perform numerical modeling of the interchange cycle in the magnetosphere-ionosphere convection system for oblique northward interplanetary magnetic field (IMF). The interchange cycle results from the coupling of IMF-to-lobe reconnection and lobe-to-closed reconnection. Using a global magnetohydrodynamic simulation code, for an IMF clock angle of 20° (measured from due north), we successfully reproduced the following features of the interchange cycle. (1) In the ionosphere, for each hemisphere, there appears a reverse cell circulating exclusively in the closed field line region (the reciprocal cell). (2) The topology transition of the magnetic field along a streamline near the equatorial plane precisely represents the magnetic flux reciprocation during the interchange cycle. (3) Field-aligned electric fields on the interplanetary-open separatrix and on the open-closed separatrix are those that are consistent with IMF-to-lobe reconnection and lobe-to-closed reconnection, respectively. These three features prove the existence of the interchange cycle in the simulated magnetosphere-ionosphere system. We conclude that the interchange cycle does exist in the real solar wind-magnetosphere-ionosphere system. In addition, the simulation revealed that the reciprocal cell described above is not a direct projection of the diffusion region as predicted by the "vacuum" model in which diffusion is added a priori to the vacuum magnetic topology. Instead, the reciprocal cell is a consequence of the plasma convection system coupled to the so-called NBZ ("northward Bz") field-aligned current system.

77 FR 21091 - Alabama Power Company; Notice of Application for Amendment of License and Soliciting Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-09

... characters, without prior registration, using the eComment system at http://www.ferc.gov/docs-filing/ecomment... applicant proposes to construct a 20-ft wide and approximately 187-ft long concrete boat ramp with courtesy dock on each side of the ramp. Ninety-four feet of the proposed boat ramp will be within the project...

Ramp compression of magnesium oxide to 234 GPa

DOE PAGES

Wang, Jue; Smith, R. F.; Coppari, F.; ...

2014-05-07

Single-crystal magnesium oxide (MgO) samples were ramp compressed to above 200 GPa pressure at the Omega laser facility. Multi-stepped MgO targets were prepared using lithography and wet etching techniques. Free surface velocities of ramp-compressed MgO were measured with a VISAR. The sound velocity and stress-density response were determined using an iterative Lagrangian analysis. The measured equation of state is consistent with expectations from previous shock and static data as well as with a recent X-ray diffraction measurement under ramp loading. The peak elastic stresses observed in our samples had amplitudes of 3-5.5 GPa, decreasing with propagation distance.

High altitude chemically reacting gas particle mixtures. Volume 3: Computer code user's and applications manual. [rocket nozzle and orbital plume flow fields

NASA Technical Reports Server (NTRS)

Smith, S. D.

1984-01-01

A users manual for the RAMP2 computer code is provided. The RAMP2 code can be used to model the dominant phenomena which affect the prediction of liquid and solid rocket nozzle and orbital plume flow fields. The general structure and operation of RAMP2 are discussed. A user input/output guide for the modified TRAN72 computer code and the RAMP2F code is given. The application and use of the BLIMPJ module are considered. Sample problems involving the space shuttle main engine and motor are included.

2. Overview showing Medical Detachment Barracks on both Ramp No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Overview showing Medical Detachment Barracks on both Ramp No. 5 (left buildings) and Ramp No. 6 (right buildings). View is to west from roof of Corridor A. Note that a pedestrian sidewalk separates buildings instead of a street for automobiles. In left foreground is the north end of Building No. 9962-B; followed by the north B-sides of Buildings Nos. 9963, 9964, 9965, 9966, 9967 and 9968 on Ramp No. 5. Large white building in far distance is a barracks on the other side of Wilson Avenue. - Madigan Hospital, Medical Detachment Barracks, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, Tacoma, Pierce County, WA

The role of temperature ramp-up time before barrier layer growth in optical and structural properties of InGaN/GaN multi-quantum wells

NASA Astrophysics Data System (ADS)

Xing, Yao; Zhao, Degang; Jiang, Desheng; Liu, Zongshun; Zhu, Jianjun; Chen, Ping; Yang, Jing; Liu, Wei; Liang, Feng; Liu, Shuangtao; Zhang, Liqun; Wang, Wenjie; Li, Mo; Zhang, Yuantao; Du, Guotong

2018-05-01

In InGaN/GaN multi-quantum wells (MQWs), a low temperature cap (LT-cap) layer is grown between the InGaN well layer and low temperature GaN barrier layer. During the growth, a temperature ramp-up and ramp-down process is added between LT-cap and barrier layer growth. The effect of temperature ramp-up time duration on structural and optical properties of quantum wells is studied. It is found that as the ramp-up time increases, the Indium floating layer on the top of the well layer can be diminished effectively, leading to a better interface quality between well and barrier layers, and the carrier localization effect is enhanced, thereby the internal quantum efficiency (IQE) of QWs increases surprisingly. However, if the ramp-up time is too long, the carrier localization effect is weaker, which may increase the probabilities of carriers to meet with nonradiative recombination centers. Meanwhile, more nonradiative recombination centers will be introduced into well layers due to the indium evaporation. Both of them will lead to a reduction of internal quantum efficiency (IQE) of MQWs.

STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition.

PubMed

Terra, Silvia R; Cardoso, João Carlos R; Félix, Rute C; Martins, Leo Anderson M; Souza, Diogo Onofre G; Guma, Fatima C R; Canário, Adelino Vicente M; Schein, Vanessa

2015-03-05

Stanniocalcin 1 (STC1) and calcitonin gene-related peptide (CGRP) are involved in bone formation/remodeling. Here we investigate the effects of STC1 on functional heterodimer complex CALCRL/RAMP1, expression and activity during osteoblastogenesis. STC1 did not modify CALCRL and ramp1 gene expression during osteoblastogenesis when compared to controls. However, plasma membrane spatial distribution of CALCRL/RAMP1 was modified in 7-day pre-osteoblasts exposed to either CGRP or STC1, and both peptides induced CALCRL and RAMP1 assembly. CGRP, but not STC1 stimulated cAMP accumulation in 7-day osteoblasts and in CALCRL/RAMP1 transfected HEK293 cells. Furthermore, STC1 inhibited forskolin stimulated cAMP accumulation of HEK293 cells, but not in CALCRL/RAMP1 transfected HEK293 cells. However, STC1 inhibited cAMP accumulation in calcitonin receptor (CTR) HEK293 transfected cells stimulated by calcitonin. In conclusion, STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The Effect of Micro-ramps on Supersonic Flow over a Forward-Facing Step

NASA Astrophysics Data System (ADS)

Zhang, Qing-Hu; Yi, Shi-He; Zhu, Yang-Zhu; Chen, Zhi; Wu, Yu

2013-04-01

The effect of micro-ramp control on fully developed turbulent flow over a forward-facing step (FFS) is investigated in a supersonic low-noise wind tunnel at Mach number 3 using nano-tracer planar laser scattering (NPLS) and supersonic particle image velocimetry (PIV) techniques. High spatiotemporal resolution images and the average velocity profiles of supersonic flow over the FFS with and without the control of the micro-ramps are captured. The fine structures of both cases, including the coherent structures of fully developed boundary layer and the large-scale hairpin-like vortices originated from the micro-ramps as well as the interaction of shock waves with the large-scale structures, are revealed and compared. Based on the time-correlation images, the temporal and spatial evolutionary characteristics of the coherent structures are investigated. It is beneficial to understand the dynamic mechanisms of the separated flow and the control mechanisms of the micro-ramps. The size of the separation region is determined by the NPLS and PIV. The results indicate that the control of the micro-ramps is capable of delaying the separation and diminishing the extent of recirculation zone.

Flat-ramp vs. convex-concave thrust geometries in a deformable hanging wall: new insights from analogue modeling experiments

NASA Astrophysics Data System (ADS)

Almeida, Pedro; Tomas, Ricardo; Rosas, Filipe; Duarte, Joao; Terrinha, Pedro

2015-04-01

Different modes of strain accommodation affecting a deformable hanging-wall in a flat-ramp-flat thrust system were previously addressed through several (sandbox) analog modeling studies, focusing on the influence of different variables, such as: a) thrust ramp dip angle and friction (Bonini et al, 2000); b) prescribed thickness of the hanging-wall (Koy and Maillot, 2007); and c) sin-thrust erosion (compensating for topographic thrust edification, e.g. Persson and Sokoutis, 2002). In the present work we reproduce the same experimental procedure to investigate the influence of two different parameters on hanging-wall deformation: 1) the geometry of the thrusting surface; and 2) the absence of a velocity discontinuity (VD) that is always present in previous similar analogue modeling studies. Considering the first variable we use two end member ramp geometries, flat-ramp-flat and convex-concave, to understand the control exerted by the abrupt ramp edges in the hanging-wall stress-strain distribution, comparing the obtain results with the situation in which such edge singularities are absent (convex-concave thrust ramp). Considering the second investigated parameter, our motivation was the recognition that the VD found in the different analogue modeling settings simply does not exist in nature, despite the fact that it has a major influence on strain accommodation in the deformable hanging-wall. We thus eliminate such apparatus artifact from our models and compare the obtained results with the previous ones. Our preliminary results suggest that both investigated variables play a non-negligible role on the structural style characterizing the hanging-wall deformation of convergent tectonic settings were such thrust-ramp systems were recognized. Acknowledgments This work was sponsored by the Fundação para a Ciência e a Tecnologia (FCT) through project MODELINK EXPL/GEO-GEO/0714/2013. Pedro Almeida wants to thank to FCT for the Ph.D. grant (SFRH/BD/52556/2014) under the Doctoral Program EarthSystems in IDL/UL. References Bonini, M., Sokoutis, D., Mulugeta, G., Katrivanos, E. (2000) - Modelling hanging wall accommodation above rigid thrust ramps. Journal of Structural Geology, 22, pp. 1165-1179. Persson, K. & Sokoutis, D (2002) - Analogue models of orogenic wedges controlled by erosion. Tectonophysics, 356, pp. 323- 336. Koy, H. & Bertrand, M. (2007) - Tectonic thickening of hanging-wall units over a ramp.Journal of Structural Geology, 29, pp. 924-932.

Risk assessment in ramps for heavy vehicles--A French study.

PubMed

Cerezo, Veronique; Conche, Florence

2016-06-01

This paper presents the results of a study dealing with the risk for heavy vehicles in ramps. Two approaches are used. On one hand, statistics are applied on several accidents databases to detect if ramps are more risky for heavy vehicles and to define a critical value for longitudinal slope. χ(2) test confirmed the risk in ramps and statistical analysis proved that a longitudinal slope superior to 3.2% represents a higher risk for heavy vehicles. On another hand, numerical simulations allow defining the speed profile in ramps for two types of heavy vehicles (tractor semi-trailer and 2-axles rigid body) and different loads. The simulations showed that heavy vehicles must drive more than 1000 m on ramps to reach their minimum speed. Moreover, when the slope is superior to 3.2%, tractor semi-trailer presents a strong decrease of their speed until 50 km/h. This situation represents a high risk of collision with other road users which drive at 80-90 km/h. Thus, both methods led to the determination of a risky configuration for heavy vehicles: ramps with a length superior to 1000 m and a slope superior to 3.2%. An application of this research work concerns design methods and guidelines. Indeed, this study provides threshold values than can be used by engineers to make mandatory specific planning like a lane for slow vehicles. Copyright © 2016 Elsevier Ltd. All rights reserved.

PDR with a Foot-Mounted IMU and Ramp Detection

PubMed Central

Jiménez, Antonio R.; Seco, Fernando; Zampella, Francisco; Prieto, José C.; Guevara, Jorge

2011-01-01

The localization of persons in indoor environments is nowadays an open problem. There are partial solutions based on the deployment of a network of sensors (Local Positioning Systems or LPS). Other solutions only require the installation of an inertial sensor on the person’s body (Pedestrian Dead-Reckoning or PDR). PDR solutions integrate the signals coming from an Inertial Measurement Unit (IMU), which usually contains 3 accelerometers and 3 gyroscopes. The main problem of PDR is the accumulation of positioning errors due to the drift caused by the noise in the sensors. This paper presents a PDR solution that incorporates a drift correction method based on detecting the access ramps usually found in buildings. The ramp correction method is implemented over a PDR framework that uses an Inertial Navigation algorithm (INS) and an IMU attached to the person’s foot. Unlike other approaches that use external sensors to correct the drift error, we only use one IMU on the foot. To detect a ramp, the slope of the terrain on which the user is walking, and the change in height sensed when moving forward, are estimated from the IMU. After detection, the ramp is checked for association with one of the existing in a database. For each associated ramp, a position correction is fed into the Kalman Filter in order to refine the INS-PDR solution. Drift-free localization is achieved with positioning errors below 2 meters for 1,000-meter-long routes in a building with a few ramps. PMID:22163701

75 FR 10015 - Notice of Final Federal Agency Actions on the Interchange of State Loop 1604 and United States...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... on the Interchange of State Loop 1604 and United States Highway 281 in Texas AGENCY: Federal Highway... agencies that are final within the meaning of 23 U.S.C. 139(l)(1). The actions relate to a proposed highway project, the interchange of Texas State Loop 1604 (LP 1604) with United States Highway 281 (US 281...

Attention Interchanges at Story-Time: A Case Study from a Deaf and Hearing Twin Pair Acquiring Swedish Sign Language in Their Deaf Family

ERIC Educational Resources Information Center

Cramer-Wolrath, Emelie

2012-01-01

This case study longitudinally analyzes and describes the changes of attentional expressions in interchanges between a pair of fraternal twins, 1 deaf and 1 hearing, from the age of 10-40 months, and their Deaf family members. The video-observed attentional expressions of initiating and reestablishing interchange were grouped in 5 functional…

29 CFR 1918.25 - Bridge plates and ramps (See also § 1918.86).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 7 2011-07-01 2011-07-01 false Bridge plates and ramps (See also § 1918.86). 1918.25... Means of Access § 1918.25 Bridge plates and ramps (See also § 1918.86). (a) Bridge and car plates (dockboards). Bridge and car plates used afloat shall be well maintained and shall: (1) Be strong enough to...

Using archived ITS data to measure the operational benefits of a system-wide adaptive ramp metering system : appendix online\\0x20106: OR\\0x2010217 NB time-space speed contour plots with meter activations.

DOT National Transportation Integrated Search

2008-12-01

Programmable logic controllers (PLCs) were installed at several key ramps with the assistance of the City of Portland and used to capture additional data about ramp operations that are not otherwise logged. The data include include the activation and...

40 CFR 1045.505 - How do I test engines using discrete-mode or ramped-modal duty cycles?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false How do I test engines using discrete... MARINE ENGINES AND VESSELS Test Procedures § 1045.505 How do I test engines using discrete-mode or ramped... allow you to perform tests with either discrete-mode or ramped-modal sampling. You must use the modal...

29 CFR 1918.25 - Bridge plates and ramps (See also § 1918.86).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Bridge plates and ramps (See also § 1918.86). 1918.25... Means of Access § 1918.25 Bridge plates and ramps (See also § 1918.86). (a) Bridge and car plates (dockboards). Bridge and car plates used afloat shall be well maintained and shall: (1) Be strong enough to...

Assessment of peak oxygen uptake during handcycling: Test-retest reliability and comparison of a ramp-incremented and perceptually-regulated exercise test.

PubMed

Hutchinson, Michael J; Paulson, Thomas A W; Eston, Roger; Goosey-Tolfrey, Victoria L

2017-01-01

To examine the reliability of a perceptually-regulated maximal exercise test (PRETmax) to measure peak oxygen uptake ([Formula: see text]) during handcycle exercise and to compare peak responses to those derived from a ramp-incremented protocol (RAMP). Twenty recreationally active individuals (14 male, 6 female) completed four trials across a 2-week period, using a randomised, counterbalanced design. Participants completed two RAMP protocols (20 W·min-1) in week 1, followed by two PRETmax in week 2, or vice versa. The PRETmax comprised five, 2-min stages clamped at Ratings of Perceived Exertion (RPE) 11, 13, 15, 17 and 20. Participants changed power output (PO) as often as required to maintain target RPE. Gas exchange variables (oxygen uptake, carbon dioxide production, minute ventilation), heart rate (HR) and PO were collected throughout. Differentiated RPE were collected at the end of each stage throughout trials. For relative [Formula: see text], coefficient of variation (CV) was equal to 4.1% and 4.8%, with ICC(3,1) of 0.92 and 0.85 for repeated measures from PRETmax and RAMP, respectively. Measurement error was 0.15 L·min-1 and 2.11 ml·kg-1·min-1 in PRETmax and 0.16 L·min-1 and 2.29 ml·kg-1·min-1 during RAMP for determining absolute and relative [Formula: see text], respectively. The difference in [Formula: see text] between PRETmax and RAMP was tending towards statistical significance (26.2 ± 5.1 versus 24.3 ± 4.0 ml·kg-1·min-1, P = 0.055). The 95% LoA were -1.9 ± 4.1 (-9.9 to 6.2) ml·kg-1·min-1. The PRETmax can be used as a reliable test to measure [Formula: see text] during handcycle exercise in recreationally active participants. Whilst PRETmax tended towards significantly greater [Formula: see text] values than RAMP, the difference is smaller than measurement error of determining [Formula: see text] from PRETmax and RAMP.

Plasma Gradient Piston: a new approach to precision pulse shaping

NASA Astrophysics Data System (ADS)

Prisbrey, Shon T.

2011-10-01

We have successfully developed a method to create shaped pressure drives from large shocks that can be applied to a wide variety of experimental platforms. The method consists of transforming a large shock or blast wave into a ramped pressured drive by utilizing a graded density reservoir that unloads across a gap and stagnates against the sample being studied. The utilization of a graded density reservoir, different materials, and a gap transforms the energy in the initial large shock into a quasi-isentropic ramped compression. Control of the ramp history is via the size of the initial shock, the chosen reservoir materials, their densities, the thickness of each density layer, and the gap size. There are two keys to utilizing this approach to create ramped drives: the ability to produce a large shock, and making the layered density reservoir. A number of facilities can produce the strong initial shock (Z, Omega, NIF, Phoenix, high explosives, NIKE, LMJ, pulsed power,...). We have demonstrated ramped drives from 0.5 to 1.5 Mbar utilizing a large shock created at the Omega laser facility. We recently concluded a pair of NIF drive shots where we successfully converted a hohlraum-generated shock into a stepped, ramped pressure drive with a peak pressure of ~4 - 5 Mbar in a Ta sample. We will explain the basic concepts needed for producing a ramped pressure drive, compare experimental data with simulations from Omega (Pmax ~ 1 Mbar) and NIF (Pmax ~ 5-10 Mbar), and present designs for ramped, staged-shock designs up to Pmax ~ 30 Mbar. The approach that we have developed enables precision pulse shaping of the drive (applied pressure vs. time) via target characteristics, as opposed to tailoring laser power vs time or Z-pinch facility current vs time. This enables ramped, quasi-isentropic materials studies to be performed on a wide variety of HED facilities. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-490532.

Formation and evolution of quasi-interchange convection cell on the HL-2A tokamak

NASA Astrophysics Data System (ADS)

Shi, P. W.; Chen, W.; Shi, Z. B.; Duan, X. R.; Zhong, W. L.; Jiang, M.; Yang, Z. C.; Yu, L. M.; Wen, J.; Liang, A. S.; Yu, D. L.; Liu, Y.; Yang, Q. W.

2018-06-01

Formation and evolution of quasi-interchange convection cell have been observed for the first time by an electron cyclotron emission imaging (ECEI) system on the HL-2A tokamak. The instability with mode numbers of m/n = -1/-1 and a frequency of 2-4 kHz propagates in the electron diamagnetic drift direction. The mode downgrades the inner stored energy WE and enhances the divertor Hα signal, which indicates a degradation of plasma confinement. The ECEI reveals that the colder core temperature fluctuation distorts to a crescent shape, while a bubble originates from hot fluctuation gradually and draws into the concave side of the crescent. A finger-like structure can be observed during the convection process, and it presents a typical feature of the quasi-interchange model. The radial structure of the interchange mode obtained from electron cyclotron emission is quite narrow at the high field side but relatively wider at the low field side. Further analysis suggests that the discharge parameters are favorable for the excitation of interchange mode, and the stability criterion is violated in the core region. Moreover, the experimental frequency agrees with that given by the linear dispersion relation of interchange instability. The large grow rate suggests that the mode grows on a very short time scale.

[Prediction and influence factors of the ramp's noise of the entrance or exit of garages].

PubMed

Di, Guo-Qing; Zhang, Bang-Jun

2005-09-01

Some typical entrances/exits of the underground garages are chosen in urban residential areas. On the basis of the optimization of the positions of the noise sampling points and the groupings of the synchronous sampling points, by means of the acoustical analysis of the noise samples, the relation of the correlative factors, among the ramps' noise of the entrances or exits of the garages, the structure, grade, shape of the ramps, upgrade and downgrade, is studied. The prediction model of the ramp's noise influence of the entrance or exit of the garage is established through amending the noise influence of the entrance or exit of the even concrete road.

Supersonic compressor

DOEpatents

Lawlor, Shawn P [Bellevue, WA; Novaresi, Mark A [San Diego, CA; Cornelius, Charles C [Kirkland, WA

2008-02-26

A gas compressor based on the use of a driven rotor having an axially oriented compression ramp traveling at a local supersonic inlet velocity (based on the combination of inlet gas velocity and tangential speed of the ramp) which forms a supersonic shockwave axially, between adjacent strakes. In using this method to compress inlet gas, the supersonic compressor efficiently achieves high compression ratios while utilizing a compact, stabilized gasdynamic flow path. Operated at supersonic speeds, the inlet stabilizes an oblique/normal shock system in the gasdyanamic flow path formed between the gas compression ramp on a strake, the shock capture lip on the adjacent strake, and captures the resultant pressure within the stationary external housing while providing a diffuser downstream of the compression ramp.

Shock formation and the ideal shape of ramp compression waves

NASA Astrophysics Data System (ADS)

Swift, Damian C.; Kraus, Richard G.; Loomis, Eric N.; Hicks, Damien G.; McNaney, James M.; Johnson, Randall P.

2008-12-01

We derive expressions for shock formation based on the local curvature of the flow characteristics during dynamic compression. Given a specific ramp adiabat, calculated for instance from the equation of state for a substance, the ideal nonlinear shape for an applied ramp loading history can be determined. We discuss the region affected by lateral release, which can be presented in compact form for the ideal loading history. Example calculations are given for representative metals and plastic ablators. Continuum dynamics (hydrocode) simulations were in good agreement with the algebraic forms. Example applications are presented for several classes of laser-loading experiment, identifying conditions where shocks are desired but not formed, and where long-duration ramps are desired.

Plasma-Assisted Control of Mach-2 Flowfield over Ramp Geometry

NASA Astrophysics Data System (ADS)

Watanabe, Yasumasa; Leonov, Sergey B.; Houpt, Alec; Hedlund, Brock E.; Elliott, Skye

2017-10-01

This study examined the effect of Reynolds number on plasma-assisted flow control ahead of a compression ramp geometry in Mach-2 supersonic flow. The experiments were conducted in the supersonic wind tunnel SBR-50 at the University of Notre Dame. Stagnation temperature and pressure were varied as T0=294-500K and P0=1-3bar to attain Reynolds number ranging from 3.4×105-2.2×106. Ramp pressure measurements, schlieren visualization, and high-speed camera imaging were used for the evaluation of plasma-assisted flow control effects. A linear dependency was found between the ramp pressure change per averaged plasma power and Reynolds number.

Positional interchanges influence the physical and technical match performance variables of elite soccer players.

PubMed

Schuth, G; Carr, G; Barnes, C; Carling, C; Bradley, P S

2016-01-01

Positional variation in match performance is well established in elite soccer but no information exists on players switching positions. This study investigated the influence of elite players interchanging from one position to another on physical and technical match performance. Data were collected from multiple English Premier League (EPL) seasons using a computerised tracking system. After adhering to stringent inclusion criteria, players were examined across several interchanges: central-defender to fullback (CD-FB, n = 11, 312 observations), central-midfielder to wide-midfielder (CM-WM, n = 7, 171 observations), wide-midfielder to central-midfielder (WM-CM, n = 7, 197 observations) and attacker to wide-midfielder (AT-WM, n = 4, 81 observations). Players interchanging from CD-FB covered markedly more high-intensity running and sprinting distance (effect size [ES]: -1.56 and -1.26), lost more possessions but made more final third entries (ES: -1.23 and -1.55). Interchanging from CM-WM and WM-CM resulted in trivial to moderate differences in both physical (ES: -0.14-0.59 and -0.21-0.39) and technical performances (ES: -0.48-0.64 and -0.36-0.54). Players interchanging from AT-WM demonstrated a moderate difference in high-intensity running without possession (ES: -0.98) and moderate-to-large differences in the number of clearances, tackles and possessions won (ES: -0.77, -1.16 and -1.41). The data demonstrate that the physical and technical demands vary greatly from one interchange to another but utility players seem able to adapt to these positional switches.

ePrescribing: Reducing Costs Through In-Class Therapeutic Interchange

PubMed Central

Stenner, Shane P.; Chakravarthy, Rohini; Johnson, Kevin B.; Miller, William L.; Olson, Julie; Wickizer, Marleen; Johnson, Nate N.; Ohmer, Rick; Uskavitch, David R.; Bernard, Gordon R.; Neal, Erin B.

2016-01-01

Summary Introduction Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Methods Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. Results For all medication classes, significant improvements were demonstrated – the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. Conclusion A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan – $17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates. PMID:27966005

Security architecture for HL/7 message interchange.

PubMed

Chen, T S; Liao, B S; Lin, M G; Gough, T G

2001-01-01

The promotion of quality medical treatment is very important to the healthcare providers as well as to patients. It requires that the medical resources of different hospitals be combined to ensure that medical information is shared and that resources are not wasted. A computer-based patient record is one of the best methods to accomplish the interchange of the patient's clinical data. In our system, the Health Level/Seven (HL/7) format is used for the interchange of the clinical data, as it has been supported by many healthcare providers and become a â standard'. The security of the interchange of clinical data is a serious issue for people using the Internet for data communication. Several international well-developed security algorithms, models and secure policies are adopted in the design of a security handler for an HL/7 architecture. The goal of our system is to combine our security system with the end-to-end communication systems constructed from the HL/7 format to establish a safe delivery channel. A suitable security interchange environment is implemented to address some shortcomings in clinical data interchange. located at the application layer of the ISO/OSI reference model. The medical message components, sub-components, and related types of message event are the primary goals of the HL/7 protocols. The patient management system, the doctor's system for recording his advice, examination and diagnosis as well as any financial management system are all covered by the HL/7 protocols. Healthcare providers and hospitals in Taiwan are very interested in developing the HL/7 protocols as a common standard for clinical data interchange.

Experimental investigation of a 0.15 scale model of a conformal variable-ramp inlet for the F-16 airplane

NASA Technical Reports Server (NTRS)

Hawkins, J. E.

1980-01-01

A 0.15 scale model of a proposed conformal variable-ramp inlet for the Multirole Fighter was tested from Mach 0.8 to 2.2 at a wide range of angles of attack and sideslip. Inlet ramp angle was varied to optimize ramp angle as a function of engine airflow, Mach number, angle of attack, and angle of sideslip. Several inlet configuration options were investigated to study their effects on inlet operation and to establish the final flight configuration. These variations were cowl sidewall cutback, cowl lip bluntness, boundary layer bleed, and first-ramp leading edge shape. Diagnostic and engine face instrumentation were used to evaluate inlet operation at various inlet stations and at the inlet/engine interface. Pressure recovery and stability of the inlet were satisfactory for the proposed application. On the basis of an engine stability audit of the worst-case instantaneous distortion patterns, no inlet/engine compatibility problems are expected for normal operations.

Tamping Ramping: Algorithmic, Implementational, and Computational Explanations of Phasic Dopamine Signals in the Accumbens

PubMed Central

Lloyd, Kevin; Dayan, Peter

2015-01-01

Substantial evidence suggests that the phasic activity of dopamine neurons represents reinforcement learning’s temporal difference prediction error. However, recent reports of ramp-like increases in dopamine concentration in the striatum when animals are about to act, or are about to reach rewards, appear to pose a challenge to established thinking. This is because the implied activity is persistently predictable by preceding stimuli, and so cannot arise as this sort of prediction error. Here, we explore three possible accounts of such ramping signals: (a) the resolution of uncertainty about the timing of action; (b) the direct influence of dopamine over mechanisms associated with making choices; and (c) a new model of discounted vigour. Collectively, these suggest that dopamine ramps may be explained, with only minor disturbance, by standard theoretical ideas, though urgent questions remain regarding their proximal cause. We suggest experimental approaches to disentangling which of the proposed mechanisms are responsible for dopamine ramps. PMID:26699940

Using archived ITS data to measure the operational benefits of a system-wide adaptive ramp metering system : appendix online\\0x20101 : I\\0x2010205 NB time\\0x2010space speed contour plots with meter activations.

DOT National Transportation Integrated Search

2008-12-01

Programmable logic controllers (PLCs) were installed at several key ramps with the assistance of the City of Portland and used to capture additional data about ramp operations that are not otherwise logged. The data include the activation and deactiv...

Numerical investigation of over expanded flow behavior in a single expansion ramp nozzle

NASA Astrophysics Data System (ADS)

Mousavi, Seyed Mahmood; Pourabidi, Reza; Goshtasbi-Rad, Ebrahim

2018-05-01

The single expansion ramp nozzle is severely over-expanded when the vehicle is at low speed, which hinders its ability to provide optimal configurations for combined cycle engines. The over-expansion leads to flow separation as a result of shock wave/boundary-layer interaction. Flow separation, and the presence of shocks themselves, result in a performance loss in the single expansion ramp nozzle, leading to reduced thrust and increased pressure losses. In the present work, the unsteady two dimensional compressible flow in an over expanded single expansion ramp nozzle has been investigated using finite volume code. To achieve this purpose, the Reynolds stress turbulence model and full multigrid initialization, in addition to the Smirnov's method for examining the errors accumulation, have been employed and the results are compared with available experimental data. The results show that the numerical code is capable of predicting the experimental data with high accuracy. Afterward, the effect of discontinuity jump in wall temperature as well as the length of straight ramp on flow behavior have been studied. It is concluded that variations in wall temperature and length of straight ramp change the shock wave boundary layer interaction, shock structure, shock strength as well as the distance between Lambda shocks.

Suitability of representative electrochemical energy storage technologies for ramp-rate control of photovoltaic power

NASA Astrophysics Data System (ADS)

Jiang, Yu; Fletcher, John; Burr, Patrick; Hall, Charles; Zheng, Bowen; Wang, Da-Wei; Ouyang, Zi; Lennon, Alison

2018-04-01

Photovoltaic (PV) systems can exhibit rapid variances in their power output due to irradiance changes which can destabilise an electricity grid. This paper presents a quantitative comparison of the suitability of different electrochemical energy storage system (ESS) technologies to provide ramp-rate control of power in PV systems. Our investigations show that, for PV systems ranging from residential rooftop systems to megawatt power systems, lithium-ion batteries with high energy densities (up to 600 Wh L-1) require the smallest power-normalised volumes to achieve the ramp rate limit of 10% min-1 with 100% compliance. As the system size increases, the ESS power-normalised volume requirements are significantly reduced due to aggregated power smoothing, with high power lithium-ion batteries becoming increasingly more favourable with increased PV system size. The possibility of module-level ramp-rate control is also introduced, and results show that achievement of a ramp rate of 10% min-1 with 100% compliance with typical junction box sizes will require ESS energy and power densities of 400 Wh L-1 and 2300 W L-1, respectively. While module-level ramp-rate control can reduce the impact of solar intermittence, the requirement is challenging, especially given the need for low cost and long cycle life.

Two-Dimensional Supersonic Nozzle Thrust Vectoring Using Staggered Ramps

NASA Astrophysics Data System (ADS)

Montes, Carlos Fernando

A novel mechanism for vectoring the thrust of a supersonic, air-breathing engine was analyzed numerically using ANSYS Fluent. The mechanism uses two asymmetrically staggered ramps; one placed at the throat, the other positioned at the exit lip of the nozzle. The nozzle was designed using published flow data, isentropic relationships, and piecewise quartic splines. The design was verified numerically and was in fair agreement with the analytical data. Using the steady-state pressure-based solver, along with the realizable kappa - epsilon turbulence model, a total of eighteen simulations were conducted: three ramp lengths at three angles, using two sets of inlet boundary conditions (non-afterburning and afterburning). The vectoring simulations showed that the afterburning flow yields a lower flow deflection distribution, shown by the calculated average deflection angle and area-weighted integrals of the distributions. The data implies that an aircraft can achieve an average thrust vectoring angle of approximately 30° in a given direction with the longest ramp length and largest ramp angle configuration. With increasing ramp angle, the static pressure across the nozzle inlet increased, causing concern for potential negative effects on the engine's turbine. The mechanism, for which a provisional patent application has been filed, will require further work to investigate the maximum possible thrust vectoring angle, including experiments.

Modeling the evolution of a ramp-flat-ramp thrust system: A geological application of DynEarthSol2D

NASA Astrophysics Data System (ADS)

Feng, L.; Choi, E.; Bartholomew, M. J.

2013-12-01

DynEarthSol2D (available at http://bitbucket.org/tan2/dynearthsol2) is a robust, adaptive, two-dimensional finite element code that solves the momentum balance and the heat equation in Lagrangian form using unstructured meshes. Verified in a number of benchmark problems, this solver uses contingent mesh adaptivity in places where shear strain is focused (localization) and a conservative mapping assisted by marker particles to preserve phase and facies boundaries during remeshing. We apply this cutting-edge geodynamic modeling tool to the evolution of a thrust fault with a ramp-flat-ramp geometry. The overall geometry of the fault is constrained by observations in the northern part of the southern Appalachian fold and thrust belt. Brittle crust is treated as a Mohr-Coulomb plastic material. The thrust fault is a zone of a finite thickness but has a lower cohesion and friction angle than its surrounding rocks. When an intervening flat separates two distinct sequential ramps crossing different stratigraphic intervals, the thrust system will experience more complex deformations than those from a single thrust fault ramp. The resultant deformations associated with sequential ramps would exhibit a spectrum of styles, of which two end members correspond to ';overprinting' and ';interference'. Reproducing these end-member styles as well as intermediate ones, our models show that the relative importance of overprinting versus interference is a sensitive function of initial fault geometry and hanging wall displacement. We further present stress and strain histories extracted from the models. If clearly distinguishable, they will guide the interpretation of field observations on thrust faults.

Behavior of a high-temperature superconducting conductor on a round core cable at current ramp rates as high as 67.8 kA s-1 in background fields of up to 19 T

NASA Astrophysics Data System (ADS)

Michael, P. C.; Bromberg, L.; van der Laan, D. C.; Noyes, P.; Weijers, H. W.

2016-04-01

High temperature superconducting (HTS) conductor-on-round-core (CORC®) cables have been developed for use in power transmission systems and large high-field magnets. The use of high-current conductors for large-scale magnets reduces system inductance and limits the peak voltage needed for ramped field operation. A CORC® cable contains a large number of RE-Ba2Cu3O7-δ (RE = rare earth) (REBCO) coated conductors, helically wound in multiple layers on a thin, round former. Large-scale applications, such as fusion and accelerator magnets, require current ramp rates of several kilo-Amperes per second during pulsed operation. This paper presents results that demonstrate the electromagnetic stability of a CORC® cable during transient conditions. Measurements were performed at 4.2 K using a 1.55 m long CORC® cable in background fields of up to 19 T. Repeated current pulses in a background field of 19 T at current ramp rates of up to 67.8 kA s-1 to approximately 90% of the cable’s quench current at that field, did not show any sign of degradation in cable performance due to excessive ac loss or electromagnetic instability. The very high current ramp rates applied during these tests were used to compensate, to the extent possible, the limited cable length accommodated by the test facility, assuming that the measured results could be extrapolated to longer length cables operated at proportionally lower current ramp rates. No shift of the superconducting transition to lower current was measured when the current ramp rate was increased from 25 A s-1 to 67.8 kA s-1. These results demonstrate the viability of CORC® cables for use in low-inductance magnets that operate at moderate to high current ramp rates.

Coupling of laser energy into plasma channels

NASA Astrophysics Data System (ADS)

Dimitrov, D. A.; Giacone, R. E.; Bruhwiler, D. L.; Busby, R.; Cary, J. R.; Geddes, C. G. R.; Esarey, E.; Leemans, W. P.

2007-04-01

Diffractive spreading of a laser pulse imposes severe limitations on the acceleration length and maximum electron energy in the laser wake field accelerator (LWFA). Optical guiding of a laser pulse via plasma channels can extend the laser-plasma interaction distance over many Rayleigh lengths. Energy efficient coupling of laser pulses into and through plasma channels is very important for optimal LWFA performance. Results from simulation parameter studies on channel guiding using the particle-in-cell (PIC) code VORPAL [C. Nieter and J. R. Cary, J. Comput. Phys. 196, 448 (2004)] are presented and discussed. The effects that density ramp length and the position of the laser pulse focus have on coupling into channels are considered. Moreover, the effect of laser energy leakage out of the channel domain and the effects of tunneling ionization of a neutral gas on the guided laser pulse are also investigated. Power spectral diagnostics were developed and used to separate pump depletion from energy leakage. The results of these simulations show that increasing the density ramp length decreases the efficiency of coupling a laser pulse to a channel and increases the energy loss when the pulse is vacuum focused at the channel entrance. Then, large spot size oscillations result in increased energy leakage. To further analyze the coupling, a differential equation is derived for the laser spot size evolution in the plasma density ramp and channel profiles are simulated. From the numerical solution of this equation, the optimal spot size and location for coupling into a plasma channel with a density ramp are determined. This result is confirmed by the PIC simulations. They show that specifying a vacuum focus location of the pulse in front of the top of the density ramp leads to an actual focus at the top of the ramp due to plasma focusing, resulting in reduced spot size oscillations. In this case, the leakage is significantly reduced and is negligibly affected by ramp length, allowing for efficient use of channels with long ramps.

Effect of initial shock wave voltage on shock wave lithotripsy-induced lesion size during step-wise voltage ramping.

PubMed

Connors, Bret A; Evan, Andrew P; Blomgren, Philip M; Handa, Rajash K; Willis, Lynn R; Gao, Sujuan

2009-01-01

To determine if the starting voltage in a step-wise ramping protocol for extracorporeal shock wave lithotripsy (SWL) alters the size of the renal lesion caused by the SWs. To address this question, one kidney from 19 juvenile pigs (aged 7-8 weeks) was treated in an unmodified Dornier HM-3 lithotripter (Dornier Medical Systems, Kennesaw, GA, USA) with either 2000 SWs at 24 kV (standard clinical treatment, 120 SWs/min), 100 SWs at 18 kV followed by 2000 SWs at 24 kV or 100 SWs at 24 kV followed by 2000 SWs at 24 kV. The latter protocols included a 3-4 min interval, between the 100 SWs and the 2000 SWs, used to check the targeting of the focal zone. The kidneys were removed at the end of the experiment so that lesion size could be determined by sectioning the entire kidney and quantifying the amount of haemorrhage in each slice. The average parenchymal lesion for each pig was then determined and a group mean was calculated. Kidneys that received the standard clinical treatment had a mean (sem) lesion size of 3.93 (1.29)% functional renal volume (FRV). The mean lesion size for the 18 kV ramping group was 0.09 (0.01)% FRV, while lesion size for the 24 kV ramping group was 0.51 (0.14)% FRV. The lesion size for both of these groups was significantly smaller than the lesion size in the standard clinical treatment group. The data suggest that initial voltage in a voltage-ramping protocol does not correlate with renal damage. While voltage ramping does reduce injury when compared with SWL with no voltage ramping, starting at low or high voltage produces lesions of the same approximate size. Our findings also suggest that the interval between the initial shocks and the clinical dose of SWs, in our one-step ramping protocol, is important for protecting the kidney against injury.

75 FR 38606 - Temporary Closure of I-70 (I-70/I-465 West Leg Interchange to the I-70/I-65 South Split...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... interchange to the I-70/I-65 south split interchange) on October 7, 2010, for a 12-hour period from 6 a.m. to... Mr. Robert Tally, FHWA Division Administrator-Indiana, (317) 226-7476. Office hours for FHWA are from...Rulemaking portal at: http://www.regulations.gov . The Web site is available 24 hours each day, 365 days each...

Application of Micro-ramp Flow Control Devices to an Oblique Shock Interaction

NASA Technical Reports Server (NTRS)

Hirt, Stefanie; Anderson, Bernhard

2007-01-01

Tests are planned in the 15cm x 15cm supersonic wind tunnel at NASA Glenn to demonstrate the applicability of micro-ramp flow control to the management of shock wave boundary layer interactions. These tests will be used as a database for computational fluid dynamics (CFD) validation and Design of Experiments (DoE) design information. Micro-ramps show potential for mechanically simple and fail-safe boundary layer control.

Using archived ITS data to measure the operational benefits of a system-wide adaptive ramp metering system : appendix online 5 : I-205 NB ramp flow & ML speed-flow plots.

DOT National Transportation Integrated Search

2008-12-01

The appendix includes various ramp flow and ML speed-flow plots, including: I-205 NB, Gladstone MP 11.05; I-205 NB, Gladstone Hway MP 12.94; I-205 NB, Lawnfield MP 13.58; I-205 NB, Sunnybrook MP 14.32; I-205 NB, Sunnyside MP 14.7; I-205 NB, Johnson C...

Slow quench dynamics of a one-dimensional Bose gas confined to an optical lattice.

PubMed

Bernier, Jean-Sébastien; Roux, Guillaume; Kollath, Corinna

2011-05-20

We analyze the effect of a linear time variation of the interaction strength on a trapped one-dimensional Bose gas confined to an optical lattice. The evolution of different observables such as the experimentally accessible on site particle distribution are studied as a function of the ramp time by using time-dependent numerical techniques. We find that the dynamics of a trapped system typically displays two regimes: For long ramp times, the dynamics is governed by density redistribution, while at short ramp times, local dynamics dominates as the evolution is identical to that of an homogeneous system. In the homogeneous limit, we also discuss the nontrivial scaling of the energy absorbed with the ramp time.

Non-stationary self-focusing of intense laser beam in plasma using ramp density profile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habibi, M.; Ghamari, F.

2011-10-15

The non-stationary self-focusing of high intense laser beam in under-dense plasma with upward increasing density ramp is investigated. The obtained results show that slowly increasing plasma density ramp is very important in enhancing laser self-focusing. Also, the spot size oscillations of laser beam in front and rear of the pulse for two different density profiles are shown. We have selected density profiles that already were used by Sadighi-Bonabi et al.[Phys. Plasmas 16, 083105 (2009)]. Ramp density profile causes the laser beam to become more focused and penetrations deeps into the plasma by reduction of diffraction effects. Our computations show moremore » reliable results in comparison to the previous works.« less

Communication growth in minimally verbal children with ASD: The importance of interaction.

PubMed

DiStefano, Charlotte; Shih, Wendy; Kaiser, Ann; Landa, Rebecca; Kasari, Connie

2016-10-01

Little is known about language development in children with Autism Spectrum Disorders (ASD) who remain minimally verbal past age 5. While there is evidence that children can develop language after age 5, we lack detailed information. Studies of this population generally focus on discrete language skills without addressing broader social-communication abilities. As communication and social deficits are both inherent to ASD, an examination of not only what language skills are acquired, but how those skills are used in interactions is relevant. Research in typical development has examined how communication interchanges (unbroken back-and-forth exchanges around a unified purpose) develop, which can be used as a framework for studying minimally verbal children. This study examined the interchange use by 55 children with ASD over the course of a 6-month play and engagement-based communication intervention. Half of the children received intervention sessions that also incorporated a speech-generating device (SGD). Interchanges were coded by: frequency, length, function, and initiator (child or adult). Results indicated that children initiated a large proportion of interchanges and this proportion increased over time. The average length and number of interchanges increased over time, with children in the SGD group showing even greater growth. Finally, children's total number of interchanges at baseline was positively associated with their spoken language gains over the course of intervention. This study supports the crucial relationship between social engagement and expressive language development, and highlights the need to include sustained communication interchanges as a target for intervention with this population. Autism Res 2016, 9: 1093-1102. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Automatic 3D high-fidelity traffic interchange modeling using 2D road GIS data

NASA Astrophysics Data System (ADS)

Wang, Jie; Shen, Yuzhong

2011-03-01

3D road models are widely used in many computer applications such as racing games and driving simulations. However, almost all high-fidelity 3D road models were generated manually by professional artists at the expense of intensive labor. There are very few existing methods for automatically generating 3D high-fidelity road networks, especially for those existing in the real world. Real road network contains various elements such as road segments, road intersections and traffic interchanges. Among them, traffic interchanges present the most challenges to model due to their complexity and the lack of height information (vertical position) of traffic interchanges in existing road GIS data. This paper proposes a novel approach that can automatically produce 3D high-fidelity road network models, including traffic interchange models, from real 2D road GIS data that mainly contain road centerline information. The proposed method consists of several steps. The raw road GIS data are first preprocessed to extract road network topology, merge redundant links, and classify road types. Then overlapped points in the interchanges are detected and their elevations are determined based on a set of level estimation rules. Parametric representations of the road centerlines are then generated through link segmentation and fitting, and they have the advantages of arbitrary levels of detail with reduced memory usage. Finally a set of civil engineering rules for road design (e.g., cross slope, superelevation) are selected and used to generate realistic road surfaces. In addition to traffic interchange modeling, the proposed method also applies to other more general road elements. Preliminary results show that the proposed method is highly effective and useful in many applications.

Successful implementation of a P&T-approved therapeutic interchange program of angiotensin II receptor blockers in a medical center in Taiwan.

PubMed

Lee, Yen-Ying; Hsiao, Paul; Lin, You-Meei; Yen, Yu-Hsuan; Chen, Hsiang-Yin

2012-01-01

Therapeutic interchange is not a common practice in the medical society in Asia. We used clinic blood pressure readings, patients' tolerance, and cost saving as measures to evaluate the impact of a therapeutic interchange program implemented at a medical center in Taiwan. Taipei Medical University-Wan Fang Hospital initiated a therapeutic interchange program involving angiotensin II receptor blockers (ARBs). Data were retrospectively collected for 444 outpatients who were converted from other ARBs to candesartan. Evaluation of therapeutic efficacy, adverse effects associated with therapy, and drug costs was conducted before and after the program implementation. Patients whose treatment was converted to candesartan experienced no statistically significant differences in blood pressure, and the average number of antihypertensive agents used per patient remained unchanged. A direct cost savings of US$62,237 was estimated for the 444 patients studied. Only 3.15% of the patients developed adverse drug reactions potentially related to candesartan, and none required hospitalization. Based on the results of this retrospective chart review, the present ARB therapeutic interchange program was successfully developed and implemented. This is the first study to establish the positive impact of a well-run ARB therapeutic interchange program in Taiwan. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Laboratory arc furnace features interchangeable hearths

NASA Technical Reports Server (NTRS)

Armstrong, J. L.; Kruger, O. L.

1967-01-01

Laboratory arc furnace using rapidly interchangeable hearths gains considerable versatility in casting so that buttons or special shaped castings can be produced. It features a sight glass for observation.

Bicoherence Analysis of Electrostatic Interchange Mode Coupling in a Turbulent Laboratory Magnetosphere

NASA Astrophysics Data System (ADS)

Abler, M. C.; Saperstein, A.; Yan, J. R.; Mauel, M. E.

2017-10-01

Plasmas confined by a strong dipole field exhibit interchange and entropy mode turbulence, which previous experiments have shown respond locally to active feedback. On the Collisionless Terrella Experiment (CTX), this turbulence is characterized by low frequency, low order, quasi-coherent modes with complex spectral dynamics. We apply bicoherence analysis to study nonlinear phase coupling in a variety of scenarios. First, we study the self-interaction of the naturally occurring interchange turbulence; this analysis is then expanded to include the effects of driven modes in the frequency range of the background turbulent oscillations. Initial measurements of coupling coefficients are presented in both cases. Driven low frequency interchange modes are observed to generate multiple harmonics which persist throughout the plasma, becoming weaker as they propagate away from the actuator in the direction of the electron magnetic drift. Future work is also discussed, including application of wavelet bicoherence analysis, excitation of interchange modes at multiple frequencies, and applications to planetary magnetospheres. Supported by NSF-DOE Partnership for Plasma Science Grants DOE-DE-FG02-00ER54585.

Ground-motion variability resulting from the January 17, 1994, M = 6.6 Northridge earthquake at the interchange between highways 14 and I-5 in the northern San Fernando Valley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hutchings, L.; Jarpe, S.; Kasameyer, P.

1994-02-04

Lawrence Livermore National Laboratory responded to the 17 January 1994, Northridge earthquake by sending an information gathering team to observe and study the collapse of the interchange between highways 14 and I-5 in the northern San Fernando Valley. This field team examined the structural failure at the interchange and the surface soil conditions, and they installed high-grain RefTek seismic recorders to record aftershocks. We recorded aftershocks for two weeks. Analyses of aftershock recordings in this report illustrate the degree of differential support motion for this site, and the higher than expected ground motion from an earthquake of this size andmore » distance. We used the aftershock recordings of small earthquakes as empirical Green`s functions and synthesized strong ground motion at three sites in the interchange area. Results presented here are based on an assumption that the geology of the interchange area remained linear in its response to the main event.« less

Interchangeability of biosimilar and biological reference product: updated regulatory positions and pre- and post-marketing evidence.

PubMed

Trifirò, Gianluca; Marcianò, Ilaria; Ingrasciotta, Ylenia

2018-03-01

Since 2006, biosimilars have been available in several countries worldwide, thus allowing for potential savings in pharmaceutical expenditure. However, there have been numerous debates about the interchangeability of biosimilars and reference products based on concerns of immunogenicity by switching between biological products, which may cause lack of effect and toxicity. Areas covered: The authors provide the reader with an overview of the different positions of regulatory authorities on the interchangeability and automatic substitution of biosimilars and reference products. Presently, the FDA allows automatic substitution without prescriber intervention if the biosimilar is interchangeable with reference products, while the European Medicines Agency delegate to each single EU member state. Expert opinion: Different approaches in defining interchangeability and automatic substitution call for harmonization to increase confidence of healthcare professionals and patients about the clinical impact of switching. Networks of electronic healthcare records and administrative databases, potentially linkable to clinical charts and registries may rapidly assess frequency and benefit-risk profile of different switching patterns in routine care at different levels, thus integrating and strengthening pre-marketing evidence.

New laparoscopic procedure for left-sided pancreatic cancer-artery-first approach laparoscopic RAMPS using 3D technique.

PubMed

Yamamoto, Michihiro; Zaima, Masazumi; Yamamoto, Hidekazu; Harada, Hideki; Kawamura, Junichiro; Yamada, Masahiro; Yazawa, Tekefumi; Kawasoe, Junya

2017-12-02

For left-sided pancreatic ductal adenocarcinoma (PDAC), radical antegrade modular pancreatosplenectomy (RAMPS) is a reasonable surgical approach for tumor-free margin resection and systemic lymph node clearance. In pancreaticoduodenectomy for PDAC, the superior mesenteric artery (SMA)-first approach (or the "artery-first approach") has become the standard procedure. With improvements in laparoscopic instruments and techniques, some surgeons attempted to apply laparoscopic RAMPS (L-RAMPS) for carefully selected patients with left-sided PDAC. However, owing to several technical difficulties in this procedure, its application remains uncommon. Moreover, the artery-first approach in L-RAMPS has not been reported. Here, we developed the artery-first approach L-RAMPS for left-sided PDAC and have presented the same in this report. Between June 2014 and July 2015, 16 patients with left-sided PDAC were referred to our division for pancreatic resection. The following technique was used for performing L-RAMPS on 3 of the 16 patients (19%). Six trocars were placed. After opening the omental bursa, only the middle segment of the pancreas was initially separated from both the left renal vein and the SMA. We termed this procedure as the "artery-first approach using a dome-shaped dorsomedial dissection (3D) technique." This 3D technique enabled the interruption of the entire arterial supply to the specimen while preserving the venous drainage through the splenic vein for preventing venous congestion. The technique also contributed to the early detection of no tumor infiltration into the SMA and the early determination of posterior dissection plane. After pancreatic neck transection, the splenic artery and vein were divided. Finally, the pancreatic tail and spleen were dissected in a right-to-left direction. All operations were completed without any intraoperative complications. The median blood loss and retrieved lymph node count were 75 mL and 37, respectively, which were superior to those reported by other previous studies on L-RAMPS. All resection margins were free of carcinoma. No severe postoperative complications were observed. The artery-first approach L-RAMPS using 3D technique is safe and feasible to perform. The significance of our proposed procedure is minimal blood loss and precise lymphadenectomy. Therefore, this novel technique may become the preferred treatment for left-sided PDAC in selected cases.

The external kink mode in diverted tokamaks

DOE PAGES

Turnbull, Alan D.; Hanson, Jeremy M.; Turco, Francesca; ...

2016-06-16

Here, an explanation is provided for the disruptive instability in diverted tokamaks when the safety factor at the 95% poloidal flux surface, q 95, is driven below 2.0. The instability is a resistive kink counterpart to the current-driven ideal mode that traditionally explained the corresponding disruption in limited cross-sections when q edge, the safety factor at the outermost closed flux surface, lies just below a rational value. Experimentally, external kink modes are observed in limiter configurations as the current in a tokamak is ramped up and q edge decreases through successive rational surfaces. For q edge < 2, the instabilitymore » is always encountered and is highly disruptive. However, diverted plasmas, in which q edge is formally infinite in the magnetohydrodynamic (MHD) model, have presented a longstanding difficulty since the theory would predict stability, yet, the disruptive limit occurs in practice when q 95, reaches 2. It is shown from numerical calculations that a resistive kink mode is linearly destabilized by the rapidly increasing resistivity at the plasma edge when q 95 < 2, but q edge >> 2. The resistive kink behaves much like the ideal kink with predominantly kink or interchange parity and no real sign of a tearing component. However, the growth rates scale with a fractional power of the resistivity near the q = 2 surface. The results have a direct bearing on the conventional edge cutoff procedures used in most ideal MHD codes, as well as implications for ITER and for future reactor options.« less

Exploring how sand ramps respond to Quaternary environmental change in Southern Africa

NASA Astrophysics Data System (ADS)

Rowell, Alex; Thomas, David; Bailey, Richard

2014-05-01

The current climate of southern Africa is particularly complex and interesting due to the interaction of several climatic systems. However, reconstructions of how these systems behaved in the past, and how the environment responded, have been hampered by a general paucity of records and poor chronological control. Sand ramps may provide the potential to improve palaeoenvironmental reconstructions of southern Africa (and beyond). Formed against a topographic barrier, sand ramps include a combination of aeolian, fluvial and colluvial deposits in varying proportions. Therefore, they have the potential to record changes in moisture availability, circulation patterns and sediment supply which can be independently dated using luminescence dating. Nevertheless relatively little attention has been paid to these features and thus the environmental controls on their formation are not yet fully understood. In particular, there is debate as to whether they reflect deposition during a 'window of opportunity' in which high-magnitude, low-frequency events are recorded (Bateman et al. 2012) or whether they record more gradual, cyclic climate change (Bertram, 2003) or even if there is a uniform control on their formation. This research aims to investigate how sand ramps respond to environmental change and what they can tell us about the paleoenvironment of southern Africa. This poster displays preliminary results based on initial field investigation. This confirmed sand ramps to be ubiquitous in southern Africa and that they record a complex interaction of aeolian, fluvial and colluvial deposits which appears to differ between sand ramps. Preliminary luminescence dating results and sedimentology are displayed for two sand ramps, one from south west Namibia the other from the Karoo region of South Africa.

Interactions between rates of temperature change and acclimation affect latitudinal patterns of warming tolerance

PubMed Central

Allen, Jessica L; Chown, Steven L; Janion-Scheepers, Charlene; Clusella-Trullas, Susana

2016-01-01

Abstract Critical thermal limits form an increasing component of the estimation of impacts of global change on ectotherms. Whether any consistent patterns exist in the interactive effects of rates of temperature change (or experimental ramping rates) and acclimation on critical thermal limits and warming tolerance (one way of assessing sensitivity to climate change) is, however, far from clear. Here, we examine the interacting effects of ramping rate and acclimation on the critical thermal maxima (CTmax) and minima (CTmin) and warming tolerance of six species of springtails from sub-tropical, temperate and polar regions. We also provide microhabitat temperatures from 26 sites spanning 5 years in order to benchmark environmentally relevant rates of temperature change. Ramping rate has larger effects than acclimation on CTmax, but the converse is true for CTmin. Responses to rate and acclimation effects are more consistent among species for CTmax than for CTmin. In the latter case, interactions among ramping rate and acclimation are typical of polar species, less marked for temperate ones, and reduced in species from the sub-tropics. Ramping rate and acclimation have substantial effects on estimates of warming tolerance, with the former being more marked. At the fastest ramping rates (>1.0°C/min), tropical species have estimated warming tolerances similar to their temperate counterparts, whereas at slow ramping rates (<0.4°C/min) the warming tolerance is much reduced in tropical species. Rates of temperate change in microhabitats relevant to the springtails are typically <0.05°C/min, with rare maxima of 0.3–0.5°C/min depending on the site. These findings emphasize the need to consider the environmental setting and experimental conditions when assessing species’ vulnerability to climate change using a warming tolerance approach. PMID:27933165

Effects of onion extract on endogenous vascular H2S and adrenomedulin in rat atherosclerosis.

PubMed

Li, Wei; Tang, Chaoshu; Jin, Hongfang; Du, Junbao

2011-09-01

This study aimed to explore the effect of onion extract on endogenous hydrogen sulfide (H2S) and adrenomedulin (ADM) and on atherosclerotic progression in rats with atherosclerosis (AS). Male Sprague-Dawley rats were randomly divided into control, AS and AS+onion groups. Ultrastructure of aorta and atherosclerotic lesions both in aorta and in coronary artery were detected. Plasma and aortic H2S were detected by using a sulfide- sensitive electrode. Plasma and aortic ADM was determined with radioimmunoassay. Cystathionine-γ-lyase (CSE), calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein (RAMP1, RAMP2 and RAMP3) mRNA expressions were analysed. Glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and NO synthase (NOS) contents in plasma, SOD1, SOD2 and ICAM-1 expressions in aorta were detected. Rats in the AS group showed marked atherosclerotic lesions both in aorta and in coronary artery but decreased aortic H2S production. Decreased plasma and aortic ADM content, but increased levels of aortic CRLR, RAMP2 and RAMP3 mRNAs were observed. Plasma GSH-PX and SOD were reduced but MDA elevated. Plasma ICAM-1 and NO contents and iNOS activity were increased. Onion extract, however, lessened atherosclerotic lesions and increased endogenous aortic H2S production, but decreased plasma ADM content, aortic ADM content and aortic CRLR, RAMP2 and RAMP3 mRNAs. In addition, it increased plasma GSH-PX level and SOD activities but reduced MDA; it decreased inflammatory response but increased plasma eNOS activity and NO content. Onion extract exerted a marked antiatherogenic effect in association with the up-regulation of the endogenous CSE/H2S pathway but down-regulation of the ADM/CRLR family in atherosclerotic rats.

Regulation of Catch Bonds by Rate of Force Application*

PubMed Central

Sarangapani, Krishna K.; Qian, Jin; Chen, Wei; Zarnitsyna, Veronika I.; Mehta, Padmaja; Yago, Tadayuki; McEver, Rodger P.; Zhu, Cheng

2011-01-01

The current paradigm for receptor-ligand dissociation kinetics assumes off-rates as functions of instantaneous force without impact from its prior history. This a priori assumption is the foundation for predicting dissociation from a given initial state using kinetic equations. Here we have invalidated this assumption by demonstrating the impact of force history with single-bond kinetic experiments involving selectins and their ligands that mediate leukocyte tethering and rolling on vascular surfaces during inflammation. Dissociation of bonds between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) loaded at a constant ramp rate to a constant hold force behaved as catch-slip bonds at low ramp rates that transformed to slip-only bonds at high ramp rates. Strikingly, bonds between L-selectin and 6-sulfo-sialyl Lewis X were impervious to ramp rate changes. This ligand-specific force history effect resembled the effect of a point mutation at the L-selectin surface (L-selectinA108H) predicted to contact the former but not the latter ligand, suggesting that the high ramp rate induced similar structural changes as the mutation. Although the A108H substitution in L-selectin eliminated the ramp rate responsiveness of its dissociation from PSGL-1, the inverse mutation H108A in P-selectin acquired the ramp rate responsiveness. Our data are well explained by the sliding-rebinding model for catch-slip bonds extended to incorporate the additional force history dependence, with Ala-108 playing a pivotal role in this structural mechanism. These results call for a paradigm shift in modeling the mechanical regulation of receptor-ligand bond dissociation, which includes conformational coupling between binding pocket and remote regions of the interacting molecules. PMID:21775439

Interactions between rates of temperature change and acclimation affect latitudinal patterns of warming tolerance.

PubMed

Allen, Jessica L; Chown, Steven L; Janion-Scheepers, Charlene; Clusella-Trullas, Susana

2016-01-01

Critical thermal limits form an increasing component of the estimation of impacts of global change on ectotherms. Whether any consistent patterns exist in the interactive effects of rates of temperature change (or experimental ramping rates) and acclimation on critical thermal limits and warming tolerance (one way of assessing sensitivity to climate change) is, however, far from clear. Here, we examine the interacting effects of ramping rate and acclimation on the critical thermal maxima (CTmax) and minima (CTmin) and warming tolerance of six species of springtails from sub-tropical, temperate and polar regions. We also provide microhabitat temperatures from 26 sites spanning 5 years in order to benchmark environmentally relevant rates of temperature change. Ramping rate has larger effects than acclimation on CTmax, but the converse is true for CTmin. Responses to rate and acclimation effects are more consistent among species for CTmax than for CTmin. In the latter case, interactions among ramping rate and acclimation are typical of polar species, less marked for temperate ones, and reduced in species from the sub-tropics. Ramping rate and acclimation have substantial effects on estimates of warming tolerance, with the former being more marked. At the fastest ramping rates (>1.0°C/min), tropical species have estimated warming tolerances similar to their temperate counterparts, whereas at slow ramping rates (<0.4°C/min) the warming tolerance is much reduced in tropical species. Rates of temperate change in microhabitats relevant to the springtails are typically <0.05°C/min, with rare maxima of 0.3-0.5°C/min depending on the site. These findings emphasize the need to consider the environmental setting and experimental conditions when assessing species' vulnerability to climate change using a warming tolerance approach.

ISO/IEC's image interchange facility

NASA Astrophysics Data System (ADS)

Blum, Christof; Hofmann, Georg R.

1992-04-01

This paper gives a technical description of the Image Interchange Facility (IIF), which comprises both a formate definition and a functional gateway specification. IIF is a part of the first International Image Processing and Interchange Standard (IPI), which is under elaboration by ISO/IEC JTC1/SC24. This paper reflects the related committee work performed up until January 1992. Considering the deficiencies and drawbacks of existing formats and current practices in exchanging digital images, the need for a new and more general approach to image interchange can be seen. This paper describes the requirements and design principles of the IIF data format and the IIF gateway. Furthermore, it explains the relation to the reference model for open communication (OSI) as well as the relation to the other parts of the IPI standard.

Vibratory high pressure coal feeder having a helical ramp

DOEpatents

Farber, Gerald

1978-01-01

Apparatus and method for feeding powdered coal from a helical ramp into a high pressure, heated, reactor tube containing hydrogen for hydrogenating the coal and/or for producing useful products from coal. To this end, the helical ramp is vibrated to feed the coal cleanly at an accurately controlled rate in a simple reliable and trouble-free manner that eliminates complicated and expensive screw feeders, and/or complicated and expensive seals, bearings and fully rotating parts.

Full-Scale Instrumented Testing and Analysis of Matting Systems for Airfield Parking Ramps and Taxiways

DTIC Science & Technology

2007-12-01

system can only be precisely determined by examining all the materials used in the mat, their structure , orientation, dimensions, etc. and determining...ER D C/ G SL T R- 07 -3 3 Full-Scale Instrumented Testing and Analysis of Matting Systems for Airfield Parking Ramps and Taxiways Chad...ERDC/GSL TR-07-33 December 2007 Full-Scale Instrumented Testing and Analysis of Matting Systems for Airfield Parking Ramps and Taxiways Chad A

T-Craft Seabase Ramp Loads Model Test Data Report

DTIC Science & Technology

2010-12-01

INTRODUCTION 1 TEST CONDITION MATRIX 2 MODEL DESCRIPTIONS 9 LMSR Model 15 Ramp Models 17 MODEL TEST SETUP 18 Side-by-Side Hull Configuration 19... INTRODUCTION The Office of Naval Research (ONR) sponsored a multiple bodied seakeeping model test designed to investigate vessel motions and loads on the hinge...C. 3. Side-by-Side configuration 137 Ramp Load cell 1.88 27.49 -CG ft I ^ -Hinged Connection 3.00 from CL to jauge • oad ce LMSR

High precision triangular waveform generator

DOEpatents

Mueller, Theodore R.

1983-01-01

An ultra-linear ramp generator having separately programmable ascending and descending ramp rates and voltages is provided. Two constant current sources provide the ramp through an integrator. Switching of the current at current source inputs rather than at the integrator input eliminates switching transients and contributes to the waveform precision. The triangular waveforms produced by the waveform generator are characterized by accurate reproduction and low drift over periods of several hours. The ascending and descending slopes are independently selectable.

High-precision triangular-waveform generator

DOEpatents

Mueller, T.R.

1981-11-14

An ultra-linear ramp generator having separately programmable ascending and decending ramp rates and voltages is provided. Two constant current sources provide the ramp through an integrator. Switching of the current at current source inputs rather than at the integrator input eliminates switching transients and contributes to the waveform precision. The triangular waveforms produced by the waveform generator are characterized by accurate reproduction and low drift over periods of several hours. The ascending and descending slopes are independently selectable.

Optimizing the current ramp-up phase for the hybrid ITER scenario

NASA Astrophysics Data System (ADS)

Hogeweij, G. M. D.; Artaud, J.-F.; Casper, T. A.; Citrin, J.; Imbeaux, F.; Köchl, F.; Litaudon, X.; Voitsekhovitch, I.; the ITM-TF ITER Scenario Modelling Group

2013-01-01

The current ramp-up phase for the ITER hybrid scenario is analysed with the CRONOS integrated modelling suite. The simulations presented in this paper show that the heating systems available at ITER allow, within the operational limits, the attainment of a hybrid q profile at the end of the current ramp-up. A reference ramp-up scenario is reached by a combination of NBI, ECCD (UPL) and LHCD. A heating scheme with only NBI and ECCD can also reach the target q profile; however, LHCD can play a crucial role in reducing the flux consumption during the ramp-up phase. The optimum heating scheme depends on the chosen transport model, and on assumptions of parameters like ne peaking, edge Te,i and Zeff. The sensitivity of the current diffusion on parameters that are not easily controlled, shows that development of real-time control is important to reach the target q profile. A first step in that direction has been indicated in this paper. Minimizing resistive flux consumption and optimizing the q profile turn out to be conflicting requirements. A trade-off between these two requirements has to be made. In this paper it is shown that fast current ramp with L-mode current overshoot is at the one extreme, i.e. the optimum q profile at the cost of increased resistive flux consumption, whereas early H-mode transition is at the other extreme.

Power ramp rate capabilities of a 5 kW proton exchange membrane fuel cell system with discrete ejector control

NASA Astrophysics Data System (ADS)

Nikiforow, K.; Pennanen, J.; Ihonen, J.; Uski, S.; Koski, P.

2018-03-01

The power ramp rate capabilities of a 5 kW proton exchange membrane fuel cell (PEMFC) system are studied theoretically and experimentally for grid support service applications. The fuel supply is implemented with a fixed-geometry ejector and a discrete control solution without any anode-side pressure fluctuation suppression methods. We show that the stack power can be ramped up from 2.0 kW to 4.0 kW with adequate fuel supply and low anode pressure fluctuations within only 0.1 s. The air supply is implemented with a centrifugal blower. Air supply ramp rates are studied with a power increase executed within 1 and 0.2 s after the request, the time dictated by grid support service requirements in Finland and the UK. We show that a power ramp-up from 2.0 kW to 3.7 kW is achieved within 1 s with an initial air stoichiometry of 2.5 and within 0.2 s with an initial air stoichiometry of 7.0. We also show that the timing of the power ramp-up affects the achieved ancillary power capacity. This work demonstrates that hydrogen fueled and ejector-based PEMFC systems can provide a significant amount of power in less than 1 s and provide valuable ancillary power capacity for grid support services.

Gap Detection in School-Age Children and Adults: Center Frequency and Ramp Duration

PubMed Central

Porter, Heather L.; Hall, Joseph W.; Grose, John H.

2017-01-01

Purpose The age at which gap detection becomes adultlike differs, depending on the stimulus characteristics. The present study evaluated whether the developmental trajectory differs as a function of stimulus frequency region or duration of the onset and offset ramps bounding the gap. Method Thresholds were obtained for wideband noise (500–4500 Hz) with 4- or 40-ms raised-cosine ramps and for a 25-Hz-wide low-fluctuation narrowband noise centered on either 500 or 5000 Hz with 40-ms ramps. Stimuli were played continuously at 70 dB SPL, and the task was to indicate which of 3 intervals contained a gap. Listeners were 5.2- to 15.1-year-old children (n = 40) and adults (n = 10) with normal hearing. Results Regardless of listener age, gap detection thresholds for the wideband noise tended to be lower when gaps were shaped using 4-ms rather than 40-ms ramps. Thresholds also tended to be lower for the low-fluctuation narrowband noise centered on 5000 Hz than 500 Hz. Performance reached adult levels after 11 years of age for all 4 stimuli. Maturation was not uniform across individuals, however; a subset of young children performed like adults, including some 5-year-olds. Conclusion For these stimuli, the developmental trajectory was similar regardless of narrowband noise center frequency or wideband noise onset and offset ramp duration. PMID:28056469

Shock-Ramp Loading of Tin and Aluminum

NASA Astrophysics Data System (ADS)

Seagle, Christopher; Davis, Jean; Martin, Matthew; Hanshaw, Heath

2013-06-01

Equation of state properties for materials off the principle Hugoniot and isentrope are currently poorly constrained. The ability to directly probe regions of phase space between the Hugoniot and isentrope under dynamic loading will greatly improve our ability to constrain equation of state properties under a variety of conditions and study otherwise inaccessible phase transitions. We have developed a technique at Sandia's Z accelerator to send a steady shock wave through a material under test, and subsequently ramp compress from the Hugoniot state. The shock-ramp experimental platform results in a unique loading path and enables probing of equation of state properties in regions of phase space otherwise difficult to access in dynamic experiments. A two-point minimization technique has been developed for the analysis of shock-ramp velocity data. The technique correctly accounts for the ``initial'' Hugoniot density of the material under test before the ramp wave arrives. Elevated quasi-isentropes have been measured for solid aluminum up to 1.4 Mbar and liquid tin up to 1.1 Mbar using the shock ramp technique. These experiments and the analysis of the resulting velocity profiles will be discussed. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85.

Experimental investigation of the micro-ramp based shock wave and turbulent boundary layer interaction control

NASA Astrophysics Data System (ADS)

Bo, Wang; Weidong, Liu; Yuxin, Zhao; Xiaoqiang, Fan; Chao, Wang

2012-05-01

Using a nanoparticle-based planar laser-scattering technique and supersonic particle image velocimetry, we investigated the effects of micro-ramp control on incident shockwave and boundary-layer interaction (SWBLI) in a low-noise supersonic wind-tunnel with Mach number 2.7 and Reynolds number Rθ = 5845. High spatiotemporal resolution wake structures downstream of the micro-ramps were detected, while a complex evolution process containing a streamwise counter-rotating vortex pair and large-scale hairpin-like vortices with Strouhal number Stδ of about 0.5-0.65 was revealed. The large-scale structures could survive while passing through the SWBLI region. Reflected shockwaves are clearly seen to be distorted accompanied by high-frequency fluctuations. Micro-ramp applications have a distinct influence on flow patterns of the SWBLI field that vary depending on spanwise locations. Both the shock foot and separation line exhibit undulations corresponding with modifications of the velocity distribution of the incoming boundary layer. Moreover, by energizing parts of the boundary flow, the micro-ramp is able to dampen the separation.

Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies.

PubMed

Ye, Yuxin; Saburi, Wataru; Odaka, Rei; Kato, Koji; Sakurai, Naofumi; Komoda, Keisuke; Nishimoto, Mamoru; Kitaoka, Motomitsu; Mori, Haruhide; Yao, Min

2016-03-01

In Ruminococcus albus, 4-O-β-D-mannosyl-D-glucose phosphorylase (RaMP1) and β-(1,4)-mannooligosaccharide phosphorylase (RaMP2) belong to two subfamilies of glycoside hydrolase family 130. The two enzymes phosphorolyze β-mannosidic linkages at the nonreducing ends of their substrates, and have substantially diverse substrate specificity. The differences in their mechanism of substrate binding have not yet been fully clarified. In the present study, we report the crystal structures of RaMP1 with/without 4-O-β-D-mannosyl-d-glucose and RaMP2 with/without β-(1→4)-mannobiose. The structures of the two enzymes differ at the +1 subsite of the substrate-binding pocket. Three loops are proposed to determine the different substrate specificities. One of these loops is contributed from the adjacent molecule of the oligomer structure. In RaMP1, His245 of loop 3 forms a hydrogen-bond network with the substrate through a water molecule, and is indispensible for substrate binding. © 2016 Federation of European Biochemical Societies.

The electromagnetic interchange mode in a partially ionized collisional plasma. [spread F region

NASA Technical Reports Server (NTRS)

Hudson, M. K.; Kennel, C. F.

1974-01-01

A collisional electromagnetic dispersion relation is derived from two-fluid theory for the interchange mode coupled to the Alfven, acoustic, drift and entropy modes in a partially ionized plasma. The fundamental electromagnetic nature of the interchange model is noted; coupling to the intermediate Alfven mode is strongly stabilizing for finite k sub z. Both ion viscous and ion-neutral stabilization are included, and it was found that collisions destroy the ion finite Larmor radius cutoff at short perpendicular wavelengths.

Power ramp induced iodine and cesium redistribution in LWR fuel rods

NASA Astrophysics Data System (ADS)

Sontheimer, F.; Vogl, W.; Ruyter, I.; Markgraf, J.

1980-01-01

Volatile fission product migration in LWR fuel rods which are power ramped above a certain threshold beyond the envelope of their previous power history, plays an important role in stress corrosion cracking of Zircaloy. This may cause fuel rods to fail already at stresses below the yield strength. In the HFR, Petten, many power ramp experiments have been performed with subsequent examination of the ramped rods for fission product distribution. This study describes the measurement of iodine and cesium distribution using γ-spectroscopy of I-131 and Cs-137. An evaluation method is presented which makes the determination of absolute amounts of I/Cs feasible. It is shown that a threshold for I/Cs redistribution exists beyond which it depends strongly on local fuel rod power and fuel type.

The microprocessor-based synthesizer controller

NASA Technical Reports Server (NTRS)

Wick, M. R.

1980-01-01

Implementation and performance of the microprocessor-based controllers and Dana Digiphase Synthesizer (DCO) installed in the Deep Space Network exciter in the 64-meter and 34-meter subnets to support uplink tuning required for the Voyager-Saturn Encounter is discussed. Test data in tests conducted during the production of the controllers verified the design objective for phase control accuracy of 10 to the - 12 power cycles in eight hours during ramping. Tests conducted require a phase error between a theoretical calculated value and the actual phase of no greater than + or - 1 cycle. Tests included (1) a ramp over a period of eight hours using a ramp rate which covers the synthesizer tuning range (40-51 MHz) and (2) a ramp sequence using the maximum rate (+ or kHz/s) over the tuning range.

Experimental investigation of a supersonic swept ramp injector using laser-induced iodine fluorescence

NASA Technical Reports Server (NTRS)

Hartfield, Roy J.; Hollo, Steven D.; Mcdaniel, James C.

1990-01-01

Planar measurements of injectant mole fraction and temperature have been conducted in a nonreacting supersonic combustor configured with underexpanded injection in the base of a swept ramp. The temperature measurements were conducted with a Mach 2 test section inlet in streamwise planes perpendicular to the test section wall on which the ramp was mounted. Injection concentration measurements, conducted in cross flow planes with both Mach 2 and Mach 2.9 free stream conditions, dramatically illustrate the domination of the mixing process by streamwise vorticity generated by the ramp. These measurements, conducted using a nonintrusive optical technique (laser-induced iodine fluorescence), provide an accurate and extensive experimental data base for the validation of computation fluid dynamic codes for the calculation of highly three-dimensional supersonic combustor flow fields.

Clinical outcomes associated with brand-to-generic phenytoin interchange.

PubMed

Kinikar, Shilpa A; Delate, Thomas; Menaker-Wiener, C Mindy; Bentley, William H

2012-05-01

Concerns that antiepileptic brand-to-generic interchange results in disruption of seizure control are widespread. However, little within-patient evidence exists examining such interchanges. To compare within-patient seizure control before and after the interchange of a branded to a single-source generic phenytoin among patients with seizures in a managed care organization. This was a pre-post, self-controlled, retrospective study. Adults with a history of seizure who used Dilantin Kapseals 100 mg extended phenytoin sodium, USP, capsules and whose therapy was interchanged to Taro Pharmaceuticals' AB-rated generic extended phenytoin sodium capsules, USP, 100 mg between July 2007 and May 2008 were included. Study outcomes included the comparisons of the proportions of patients with at least emergency department (ED) visit/inpatient hospitalization and medical office visit/nonoffice consultation for acute seizure in the 6 months before and after interchange. Outcomes were confirmed with manual chart reviews and adjusted for potential confounding medication use. A total of 222 patients were included in the study. Patients were primarily middle-aged (mean 56 years), equally mixed by sex (47% female); most had nonintractable seizures. The majority of patients (~70%) were on phenytoin as monotherapy and had equivalent rates of purchases for potentially confounding medications in both pre- and postinterchange time periods (all p > 0.05). Low serum concentrations were detected more often in the postinterchange study period (adjusted p < 0.001). Despite this, there were low proportions of patients with confirmed seizure events that resulted in an ED visit/inpatient hospitalization in both pre- and postinterchange periods (both 6.3%, adjusted p = 0.937). The proportion of patients with confirmed seizure events diagnosed at a medical office visit was not significantly different between the preinterchange and postinterchange periods (12.2% vs 11.3%, adjusted p = 0.545). No increased proportion of seizures was observed within patients when branded phenytoin was interchanged to an AB-rated, single-source, generic equivalent. More rigorous studies should be conducted to more thoroughly evaluate patient tolerability and drug efficacy when antiepileptic drugs are interchanged from brand to generic formulations.

Ramp-edge structured tunneling devices using ferromagnet electrodes

DOEpatents

Kwon, Chuhee [Long Beach, CA; Jia, Quanxi [Los Alamos, NM

2002-09-03

The fabrication of ferromagnet-insulator-ferromagnet magnetic tunneling junction devices using a ramp-edge geometry based on, e.g., (La.sub.0.7 Sr.sub.0.3) MnO.sub.3, ferromagnetic electrodes and a SrTiO.sub.3 insulator is disclosed. The maximum junction magnetoresistance (JMR) as large as 23% was observed below 300 Oe at low temperatures (T<100 K). These ramp-edge junctions exhibited JMR of 6% at 200 K with a field less than 100 Oe.

Using archived ITS data to measure the operational benefits of a system-wide adaptive ramp metering system : appendix online 10 : OR\\0x2010217 NB ramp flow & ML speed-flow plots.

DOT National Transportation Integrated Search

2008-12-01

The appendix includes various ramp flow and ML speed-flow plots: OR-217 NB, 72nd MP 6.61; OR-217 NB, 99W-EB MP 5.9; OR-217 NB, 99W-WB MP 5.85; OR-217 NB, Greenburg MP 4.65; OR-217 NB, Scholls MP 3.85; OR-217 NB, Denney MP 2.68; OR-217 NB, Allen MP 2....

Mars pathfinder Rover egress deployable ramp assembly

NASA Technical Reports Server (NTRS)

Spence, Brian R.; Sword, Lee F.

1996-01-01

The Mars Pathfinder Program is a NASA Discovery Mission, led by the Jet Propulsion Laboratory, to launch and place a small planetary Rover for exploration on the Martian surface. To enable safe and successful egress of the Rover vehicle from the spacecraft, a pair of flight-qualified, deployable ramp assemblies have been developed. This paper focuses on the unique, lightweight deployable ramp assemblies. A brief mission overview and key design requirements are discussed. Design and development activities leading to qualification and flight systems are presented.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milkov, Mihail M.

A comparator circuit suitable for use in a column-parallel single-slope analog-to-digital converter comprises a comparator, an input voltage sampling switch, a sampling capacitor arranged to store a voltage which varies with an input voltage when the sampling switch is closed, and a local ramp buffer arranged to buffer a global voltage ramp applied at an input. The comparator circuit is arranged such that its output toggles when the buffered global voltage ramp exceeds the stored voltage. Both DC- and AC-coupled comparator embodiments are disclosed.

4. RAMP FOR BENJAMIN FRANKLIN BRIDGE (FOURTH ST.) BETWEEN VINE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. RAMP FOR BENJAMIN FRANKLIN BRIDGE (FOURTH ST.) BETWEEN VINE AND RACE STS., LOOKING NORTHWEST - Independence National Historical Park, Walnut, Sixth, Chestnut & Second Streets, Philadelphia, Philadelphia County, PA

Recycling silicon wire-saw slurries: separation of silicon and silicon carbide in a ramp settling tank under an applied electrical field.

PubMed

Tsai, Tzu-Hsuan; Shih, Yu-Pei; Wu, Yung-Fu

2013-05-01

The growing demand for silicon solar cells in the global market has greatly increased the amount of silicon sawing waste produced each year. Recycling kerf Si and SiC from sawing waste is an economical method to reduce this waste. This study reports the separation of Si and SiC using a ramp settling tank. As they settle in an electrical field, small Si particles with higher negative charges have a longer horizontal displacement than SiC particles in a solution of pH 7, resulting in the separation of Si and SiC. The agreement between experimental results and predicted results shows that the particles traveled a short distance to reach the collection port in the ramp tank. Consequently, the time required for tiny particles to hit the tank bottom decreased, and the interference caused by the dispersion between particles and the fluid motion during settling decreased. In the ramp tank, the highest purities of the collected SiC and Si powders were 95.2 and 7.01 wt%, respectively. Using a ramp tank, the recycling fraction of Si-rich powders (SiC < 15 wt%) reached 22.67% (based on the whole waste). This fraction is greater than that achieved using rectangular tanks. Recycling Si and SiC abrasives from the silicon sawing waste is regarded as an economical solution to reduce the sawing waste. However, the separation of Si and SiC is difficult. This study reports the separation of Si and SiC using a ramp settling tank under an applied electrical field. As they settle in an electrical field, small Si particles with higher negative charges have a longer horizontal displacement than SiC particles in a solution of pH 7, resulting in the separation of Si and SiC. Compared with the rectangular tanks, the recycling fraction of Si-rich powders using a ramp tank is greater, and the proposed ramp settling tank is more suitable for industrial applications.

Limit Interchange and L'Hopital's Rule

ERIC Educational Resources Information Center

Ecker, Michael W.

2011-01-01

Conventional application of these two calculus staples is stretched here, somewhat recreationally, but also to raise solid questions about the role of limit interchange in analysis--without, however, delving any deeper than first-year Calculus.

Design and operation of diamond interchanges.

DOT National Transportation Integrated Search

1961-08-01

This report is a presentation of results obtained from research studies on : diamond interchanges conducted by the Texas Transportation Institute in cooperation with the Texas Highway Department. These studies were conducted : in connection with Rese...

Cone penetrometer comparison testing.

DOT National Transportation Integrated Search

2011-01-01

A total of 61 cone penetration tests were performed at 14 sites in the state of Wisconsin. Data : reinforced conclusions from practice in Minnesota and previously performed test programs : related to the Marquette Interchange and Mitchell interchange...

32. Underside of tracks showing columns, concreteencased Ibeams, and ramps ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. Underside of tracks showing columns, concrete-encased I-beams, and ramps near storage room. Looking southwest. - Stillwell Avenue Station, Intersection of Stillwell & Surf Avenues, Brooklyn, Kings County, NY

Staying Mobile

MedlinePlus

... representatives are factory-trained accessibility specialists in ramp design and installation and will provide a free evaluation and consultation to determine what ramp is best for your needs. Video Series Free From Falls Some MS symptoms and treatments ...

3. Cement and Plaster Warehouse, north facade. Loading ramp on ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Cement and Plaster Warehouse, north facade. Loading ramp on the right. Utility building, intrusion, on the far right. - Curtis Wharf, Cement & Plaster Warehouse, O & Second Streets, Anacortes, Skagit County, WA

36 CFR 1192.101 - Lighting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Cars and Systems § 1192.101 Lighting. (a) Any stepwell or doorway with a lift, ramp or bridge plate..., ramp, bridge plate, or lift platform. (b) The doorways of cars not operating at lighted station...

36 CFR 1192.119 - Lighting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Cars and Systems § 1192.119 Lighting. (a) Any stepwell, or doorway with a lift, ramp or bridge plate..., ramp, bridge plate or lift platform. (b) The doorways of cars not operating at lighted station...

36 CFR 1192.119 - Lighting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Cars and Systems § 1192.119 Lighting. (a) Any stepwell, or doorway with a lift, ramp or bridge plate..., ramp, bridge plate or lift platform. (b) The doorways of cars not operating at lighted station...

36 CFR 1192.101 - Lighting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Cars and Systems § 1192.101 Lighting. (a) Any stepwell or doorway with a lift, ramp or bridge plate..., ramp, bridge plate, or lift platform. (b) The doorways of cars not operating at lighted station...

West view, general; Station Building, covered ramp, and Street Car ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West view, general; Station Building, covered ramp, and Street Car Waiting House - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

Analysis Balance Parameter of Optimal Ramp metering

NASA Astrophysics Data System (ADS)

Li, Y.; Duan, N.; Yang, X.

2018-05-01

Ramp metering is a motorway control method to avoid onset congestion through limiting the access of ramp inflows into the main road of the motorway. The optimization model of ramp metering is developed based upon cell transmission model (CTM). With the piecewise linear structure of CTM, the corresponding motorway traffic optimization problem can be formulated as a linear programming (LP) problem. It is known that LP problem can be solved by established solution algorithms such as SIMPLEX or interior-point methods for the global optimal solution. The commercial software (CPLEX) is adopted in this study to solve the LP problem within reasonable computational time. The concept is illustrated through a case study of the United Kingdom M25 Motorway. The optimal solution provides useful insights and guidances on how to manage motorway traffic in order to maximize the corresponding efficiency.

Experimental studies on flow visualization and velocity field of compression ramp with different incoming boundary layers

NASA Astrophysics Data System (ADS)

Wu, Yu; Yi, Shi-He; He, Lin; Chen, Zhi; Zhu, Yang-Zhu

2014-11-01

Experimental studies which focus on flow visualization and the velocity field of a supersonic laminar/turbulent flow over a compression ramp were carried out in a Mach 3.0 wind tunnel. Fine flow structures and velocity field structures were obtained via NPLS (nanoparticle-tracer planar laser scattering) and PIV (particle image velocimetry) techniques, time-averaged flow structures were researched, and spatiotemporal evolutions of transient flow structures were analyzed. The flow visualization results indicated that when the ramp angles were 25°, a typical separation occurred in the laminar flow, some typical flow structures such as shock induced by the boundary layer, separation shock, reversed flow and reattachment shock were visible clearly. While a certain extent separation occurred in turbulent flow, the separation region was much smaller. When the ramp angles were 28°, laminar flow separated further, and the separation region expanded evidently, flow structures in the separation region were complex. While a typical separation occurred in turbulent flow, reversed flow structures were significant, flow structures in the separation region were relatively simple. The experimental results of velocity field were corresponding to flow visualization, and the velocity field structures of both compression ramp flows agreed with the flow structures well. There were three layered structures in the U component velocity, and the V component velocity appeared like an oblique “v”. Some differences between these two compression ramp flows can be observed in the velocity profiles of the shear layer and the shearing intensity.

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

PubMed

Weston, Cathryn; Winfield, Ian; Harris, Matthew; Hodgson, Rose; Shah, Archna; Dowell, Simon J; Mobarec, Juan Carlos; Woodlock, David A; Reynolds, Christopher A; Poyner, David R; Watkins, Harriet A; Ladds, Graham

2016-10-14

The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of the three peptide ligands, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM2), is well known to result in a Gα s -mediated increase in cAMP. Here we used modified yeast strains that couple receptor activation to cell growth, via chimeric yeast/Gα subunits, and HEK-293 cells to characterize the effect of different RAMP and ligand combinations on this pathway. We not only demonstrate functional couplings to both Gα s and Gα q but also identify a Gα i component to CLR signaling in both yeast and HEK-293 cells, which is absent in HEK-293S cells. We show that the CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Gα s , Gα i , and Gα q/11 pathways. The results are discussed in the context of RAMP interactions probed through molecular modeling and molecular dynamics simulations of the RAMP-GPCR-G protein complexes. This study further highlights the importance of RAMPs to CLR pharmacology and to bias in general, as well as identifying the importance of choosing an appropriate model system for the study of GPCR pharmacology. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Arctic warming will promote Atlantic-Pacific fish interchange

NASA Astrophysics Data System (ADS)

Wisz, M. S.; Broennimann, O.; Grønkjær, P.; Møller, P. R.; Olsen, S. M.; Swingedouw, D.; Hedeholm, R. B.; Nielsen, E. E.; Guisan, A.; Pellissier, L.

2015-03-01

Throughout much of the Quaternary Period, inhospitable environmental conditions above the Arctic Circle have been a formidable barrier separating most marine organisms in the North Atlantic from those in the North Pacific. Rapid warming has begun to lift this barrier, potentially facilitating the interchange of marine biota between the two seas. Here, we forecast the potential northward progression of 515 fish species following climate change, and report the rate of potential species interchange between the Atlantic and the Pacific via the Northwest Passage and the Northeast Passage. For this, we projected niche-based models under climate change scenarios and simulated the spread of species through the passages when climatic conditions became suitable. Results reveal a complex range of responses during this century, and accelerated interchange after 2050. By 2100 up to 41 species could enter the Pacific and 44 species could enter the Atlantic, via one or both passages. Consistent with historical and recent biodiversity interchanges, this exchange of fish species may trigger changes for biodiversity and food webs in the North Atlantic and North Pacific, with ecological and economic consequences to ecosystems that at present contribute 39% to global marine fish landings.

133. AERIAL VIEW OF CLARA BARTON PARKWAY AND I495 INTERCHANGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

133. AERIAL VIEW OF CLARA BARTON PARKWAY AND I-495 INTERCHANGE LOOKING EAST. - George Washington Memorial Parkway, Along Potomac River from McLean to Mount Vernon, VA, Mount Vernon, Fairfax County, VA

Roundabouts : an Arizona case study and design guidelines

DOT National Transportation Integrated Search

2003-07-01

The roundabouts controlling traffic at the I-17/Happy Valley Road interchange represent Arizona's first application of modern roundabout traffic control in this manner. The construction of roundabouts at this interchange location served to alleviate ...

Probabilistic Wind Power Ramp Forecasting Based on a Scenario Generation Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Qin; Florita, Anthony R; Krishnan, Venkat K

Wind power ramps (WPRs) are particularly important in the management and dispatch of wind power and currently drawing the attention of balancing authorities. With the aim to reduce the impact of WPRs for power system operations, this paper develops a probabilistic ramp forecasting method based on a large number of simulated scenarios. An ensemble machine learning technique is first adopted to forecast the basic wind power forecasting scenario and calculate the historical forecasting errors. A continuous Gaussian mixture model (GMM) is used to fit the probability distribution function (PDF) of forecasting errors. The cumulative distribution function (CDF) is analytically deduced.more » The inverse transform method based on Monte Carlo sampling and the CDF is used to generate a massive number of forecasting error scenarios. An optimized swinging door algorithm is adopted to extract all the WPRs from the complete set of wind power forecasting scenarios. The probabilistic forecasting results of ramp duration and start-time are generated based on all scenarios. Numerical simulations on publicly available wind power data show that within a predefined tolerance level, the developed probabilistic wind power ramp forecasting method is able to predict WPRs with a high level of sharpness and accuracy.« less

Ramp compression of a metallic liner driven by a shaped 5 MA current on the SPHINX machine

NASA Astrophysics Data System (ADS)

D'Almeida, Thierry; Lassalle, Francis; Morell, Alain; Grunenwald, Julien; Zucchini, Frédéric; Loyen, Arnaud; Maysonnave, Thomas; Chuvatin, Alexandre

2013-06-01

SPHINX is a 6MA, 1- μs Linear Transformer Driver operated by the CEA Gramat (France) and primarily used for imploding Z-pinch loads for radiation effects studies. Among the options that are currently being considered for improving the generator performances, there is a compact Dynamic Load Current Amplifier (DLCM). A method for performing magnetic ramp compression experiments, without modifying the generator operation scheme, was developed using the DLCM to shape the initial current pulse. We present the overall experimental configuration chosen for these experiments, based on electrical and hydrodynamic simulations. Initial results obtained over a set of experiments on an aluminum cylindrical liner, ramp-compressed to a peak pressure of 23 GPa, are presented. Details of the electrical and Photonic Doppler Velocimetry (PDV) setups used to monitor and diagnose the ramp compression experiments are provided. Current profiles measured at various locations across the system, particularly the load current, agree with simulated current profile and demonstrate adequate pulse shaping by the DLCM. The liner inner free surface velocity measurements agree with the hydrocode results obtained using the measured load current as the input. Higher ramp pressure levels are foreseen in future experiments with an improved DLCM system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jie; Cui, Mingjian; Hodge, Bri-Mathias

The large variability and uncertainty in wind power generation present a concern to power system operators, especially given the increasing amounts of wind power being integrated into the electric power system. Large ramps, one of the biggest concerns, can significantly influence system economics and reliability. The Wind Forecast Improvement Project (WFIP) was to improve the accuracy of forecasts and to evaluate the economic benefits of these improvements to grid operators. This paper evaluates the ramp forecasting accuracy gained by improving the performance of short-term wind power forecasting. This study focuses on the WFIP southern study region, which encompasses most ofmore » the Electric Reliability Council of Texas (ERCOT) territory, to compare the experimental WFIP forecasts to the existing short-term wind power forecasts (used at ERCOT) at multiple spatial and temporal scales. The study employs four significant wind power ramping definitions according to the power change magnitude, direction, and duration. The optimized swinging door algorithm is adopted to extract ramp events from actual and forecasted wind power time series. The results show that the experimental WFIP forecasts improve the accuracy of the wind power ramp forecasting. This improvement can result in substantial costs savings and power system reliability enhancements.« less

Time dependent heat transfer rates in high Reynolds number hypersonic flowfields

NASA Technical Reports Server (NTRS)

Flanagan, Michael J.

1992-01-01

Time dependent heat transfer rates have been calculated from time dependent temperature measurements in the vicinity of shock-wave boundary-layer interactions due to conical compression ramps on an axisymmetric body. The basic model is a cylindrical body with a 10 degree conical nose. Four conical ramps, 20, 25, 30, and 35 degrees serve as shock wave generators. Flowfield surveys have been made in the vicinity of the conical ramp vertex, the separation point, and the reattachment point. A significant effort was made to characterize the natural frequencies and relative powers of the resulting fluctuations in heat transfer rates. This research effort, sponsored jointly by NASA and the Air Force, was conducted in the Air Force Flight Dynamics Directorate High Reynolds Facility. The nominal freestream Mach number was 6, and the freestream Reynolds numbers ranged from 2.2 million/ft to 30.0 million/ft. Experimental results quantify temperature response and the resulting heat transfer rates as a function of ramp angle and Reynolds number. The temperature response within the flowfield appears to be steady-state for all compression ramp angles and all Reynolds numbers, and hence, the heat transfer rates appear to be steady-state.

Time dependent heat transfer rates in high Reynolds number hypersonic flowfields

NASA Astrophysics Data System (ADS)

Flanagan, Michael J.

1992-09-01

Time dependent heat transfer rates have been calculated from time dependent temperature measurements in the vicinity of shock-wave boundary-layer interactions due to conical compression ramps on an axisymmetric body. The basic model is a cylindrical body with a 10 degree conical nose. Four conical ramps, 20, 25, 30, and 35 degrees serve as shock wave generators. Flowfield surveys have been made in the vicinity of the conical ramp vertex, the separation point, and the reattachment point. A significant effort was made to characterize the natural frequencies and relative powers of the resulting fluctuations in heat transfer rates. This research effort, sponsored jointly by NASA and the Air Force, was conducted in the Air Force Flight Dynamics Directorate High Reynolds Facility. The nominal freestream Mach number was 6, and the freestream Reynolds numbers ranged from 2.2 million/ft to 30.0 million/ft. Experimental results quantify temperature response and the resulting heat transfer rates as a function of ramp angle and Reynolds number. The temperature response within the flowfield appears to be steady-state for all compression ramp angles and all Reynolds numbers, and hence, the heat transfer rates appear to be steady-state.

Evaluation of Pushback Decision-Support Tool Concept for Charlotte Douglas International Airport Ramp Operations

NASA Technical Reports Server (NTRS)

Hayashi, Miwa; Hoang, Ty; Jung, Yoon C.; Malik, Waqar; Lee, Hanbong; Dulchinos, Victoria L.

2015-01-01

This paper proposes a new departure pushback decision-support tool (DST) for airport ramp-tower controllers. It is based on NASA's Spot and Runway Departure Advisor (SARDA) collaborative decision-making concept, except with the modification that the gate releases now are controlled by tactical pushback (or gate-hold) advisories instead of strategic pre-assignments of target pushback times to individual departure flights. The proposed ramp DST relies on data exchange with the airport traffic control tower (ATCT) to coordinate pushbacks with the ATCT's flow-management intentions under current operational constraints, such as Traffic Management Initiative constraints. Airlines would benefit in reduced taxi delay and fuel burn. The concept was evaluated in a human-in-the-loop simulation experiment with current ramp-tower controllers at the Charlotte Douglas International Airport as participants. The results showed that the tool helped reduce taxi time by one minute per flight and overall departure flight fuel consumption by 10-12% without reducing runway throughput. Expect Departure Clearance Time (EDCT) conformance also was improved when advisories were provided. These benefits were attained without increasing the ramp-tower controllers' workload. Additionally, the advisories reduced the ATCT controllers' workload.

Probabilistic Wind Power Ramp Forecasting Based on a Scenario Generation Method: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Qin; Florita, Anthony R; Krishnan, Venkat K

2017-08-31

Wind power ramps (WPRs) are particularly important in the management and dispatch of wind power, and they are currently drawing the attention of balancing authorities. With the aim to reduce the impact of WPRs for power system operations, this paper develops a probabilistic ramp forecasting method based on a large number of simulated scenarios. An ensemble machine learning technique is first adopted to forecast the basic wind power forecasting scenario and calculate the historical forecasting errors. A continuous Gaussian mixture model (GMM) is used to fit the probability distribution function (PDF) of forecasting errors. The cumulative distribution function (CDF) ismore » analytically deduced. The inverse transform method based on Monte Carlo sampling and the CDF is used to generate a massive number of forecasting error scenarios. An optimized swinging door algorithm is adopted to extract all the WPRs from the complete set of wind power forecasting scenarios. The probabilistic forecasting results of ramp duration and start time are generated based on all scenarios. Numerical simulations on publicly available wind power data show that within a predefined tolerance level, the developed probabilistic wind power ramp forecasting method is able to predict WPRs with a high level of sharpness and accuracy.« less

Self-focusing and defocusing of Gaussian laser beams in collisional inhomogeneous plasmas with linear density and temperature ramps

NASA Astrophysics Data System (ADS)

Hashemzadeh, M.

2018-01-01

Self-focusing and defocusing of Gaussian laser beams in collisional inhomogeneous plasmas are investigated in the presence of various laser intensities and linear density and temperature ramps. Considering the ponderomotive force and using the momentum transfer and energy equations, the nonlinear electron density is derived. Taking into account the paraxial approximation and nonlinear electron density, a nonlinear differential equation, governing the focusing and defocusing of the laser beam, is obtained. Results show that in the absence of ramps the laser beam is focused between a minimum and a maximum value of laser intensity. For a certain value of laser intensity and initial electron density, the self-focusing process occurs in a temperature range which reaches its maximum at turning point temperature. However, the laser beam is converged in a narrow range for various amounts of initial electron density. It is indicated that the σ2 parameter and its sign can affect the self-focusing process for different values of laser intensity, initial temperature, and initial density. Finally, it is found that although the electron density ramp-down diverges the laser beam, electron density ramp-up improves the self-focusing process.

ALINEA local ramp metering : summary of field results

DOT National Transportation Integrated Search

1997-01-01

Asservissement Linaire dEntre Autoroutire (ALINEA), a local feedback ramp-metering strategy, has had multiple field applications, and more applications are planned in several European countries. The main features of ALINEA are presented and ...

49 CFR 38.119 - Lighting.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., or doorway with a lift, ramp or bridge plate, shall have, when the door is open, at least 2 foot-candles of illumination measured on the step tread, ramp, bridge plate or lift platform. (b) The doorways...

49 CFR 38.119 - Lighting.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., or doorway with a lift, ramp or bridge plate, shall have, when the door is open, at least 2 foot-candles of illumination measured on the step tread, ramp, bridge plate or lift platform. (b) The doorways...

49 CFR 38.101 - Lighting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... doorway with a lift, ramp or bridge plate shall have, when the door is open, at least 2 footcandles of illumination measured on the step tread, ramp, bridge plate, or lift platform. (b) The doorways of cars not...

49 CFR 38.101 - Lighting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... doorway with a lift, ramp or bridge plate shall have, when the door is open, at least 2 footcandles of illumination measured on the step tread, ramp, bridge plate, or lift platform. (b) The doorways of cars not...

30. Underside of tracks showing columns, concreteencased Ibeams, and ramps ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Underside of tracks showing columns, concrete-encased I-beams, and ramps near token booths at street level. Looking southeast. - Stillwell Avenue Station, Intersection of Stillwell & Surf Avenues, Brooklyn, Kings County, NY

WALK UP RAMP - ASTRONAUT THOMAS P. STAFFORD - MISC.

NASA Image and Video Library

1966-06-03

S66-32149 (3 June 1966) --- Astronauts Thomas P. Stafford (foreground), command pilot, and Eugene A. Cernan, pilot, walk up the ramp at Pad 19 during the Gemini-9A prelaunch countdown. Photo credit: NASA

North rear, east part. Ramp leads to basement utility rooms ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North rear, east part. Ramp leads to basement utility rooms and specimen preparation rooms. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

Statistical Characteristics of Wrong-Way Driving Crashes on Illinois Freeways.

PubMed

Zhou, Huaguo; Zhao, Jiguang; Pour-Rouholamin, Mahdi; Tobias, Priscilla A

2015-01-01

Driving the wrong way on freeways, namely wrong-way driving (WWD), has been found to be a major concern for more than 6 decades. The purpose of this study was to identify characteristics of this type of crash as well as to rank the locations/interchanges according to their vulnerability to WWD entries. The WWD crash data on Illinois freeways were statistically analyzed for a 6-year time period (2004 to 2009) from 3 aspects: crash, vehicle, and person. The temporal distributions, geographical distributions, roadway characteristics, and crash locations were analyzed for WWD crashes. The driver demographic information, physical condition, and injury severity were analyzed for wrong-way drivers. The vehicle characteristics, vehicle operation, and collision results were analyzed for WWD vehicles. A method was brought about to identify wrong-way entry points that was then used to develop a relative-importance technique and rank different interchange types in terms of potential WWD incidents. The findings revealed that a large proportion of WWD crashes occurred during the weekend from midnight to 5 a.m. Approximately 80% of WWD crashes were located in urban areas and nearly 70% of wrong-way vehicles were passenger cars. Approximately 58% of wrong-way drivers were driving under the influence (DUI). Of those, nearly 50% were confirmed to be impaired by alcohol, about 4% were impaired by drugs, and more than 3% had been drinking. The analysis of interchange ranking found that compressed diamond interchanges, single point diamond interchanges (SPDIs), partial cloverleaf interchanges, and freeway feeders had the highest wrong-way crash rates (wrong-way crashes per 100 interchanges per year). The findings of this study call for more attention to WWD crashes from different aspects such as driver age group, time of day, day of week, and DUI drivers. Based on the analysis results of WWD distance, the study explained why a 5-mile radius of WWD crash location should be studied for WWD fatal crashes with unknown entry points.

Diverging diamond interchange : informational guide.

DOT National Transportation Integrated Search

2014-08-01

This document provides information and guidance on the Diverging Diamond Interchange (DDI). To the extent possible, the guide : addresses a variety of conditions found in the United States, to achieve designs suitable for a wide array of potential us...

Interchange Safety Analysis Tool (ISAT) : user manual

DOT National Transportation Integrated Search

2007-06-01

This User Manual describes the usage and operation of the spreadsheet-based Interchange Safety Analysis Tool (ISAT). ISAT provides design and safety engineers with an automated tool for assessing the safety effects of geometric design and traffic con...

Alternate-1 and Alternate-2 Orientations in Interchange (Reciprocal Translocation) Quadrivalents

PubMed Central

Rickards, Geoffrey K.

1983-01-01

The dynamic properties of the spindle, and published numerical data, argue that the differentiation of alternate-1 and alternate-2 orientations of an interchange quadrivalent is real and meaningful, contra Boussy (1982). PMID:17246129

A comprehensive safety assessment methodology for innovative geometric designs.

DOT National Transportation Integrated Search

2017-05-01

As the population grows and travel demands increase, alternative interchange designs have become increasingly popular. The diverging diamond interchange is an alternative design that has been implemented in the United States. This design can accommod...

Stress absorbing membrane innerlayer : final report.

DOT National Transportation Integrated Search

1985-04-01

The westbound lanes of the South Baker Interchange-Encina Interchange Section of I-84 were overlayed in 1977. A stress absorbing membrane innerlayer (SAMI), was included in this overlay as an experimental feature. This report is the final evaluation ...

The formation of blobs from a pure interchange process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, P., E-mail: pzhu@ustc.edu.cn; Department of Engineering Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706; Sovinec, C. R.

2015-02-15

In this work, we focus on examining a pure interchange process in a shear-less slab configuration as a prototype mechanism for blob formation. We employ full magnetohydrodynamic simulations to demonstrate that the blob-like structures can emerge through the nonlinear development of a pure interchange instability originating from a pedestal-like transition region. In the early nonlinear stage, filamentary structures develop and extend in the direction of the effective gravity. The blob-like structures appear when the radially extending filaments break off and disconnect from the core plasma. The morphology and the dynamics of these filaments and blobs vary dramatically with a sensitivemore » dependence on the dissipation mechanisms in the system and the initial perturbation. Despite the complexity in morphology and dynamics, the nature of the entire blob formation process in the shear-less slab configuration remains strictly interchange without involving any change in magnetic topology.« less

A Cross-Classified CFA-MTMM Model for Structurally Different and Nonindependent Interchangeable Methods.

PubMed

Koch, Tobias; Schultze, Martin; Jeon, Minjeong; Nussbeck, Fridtjof W; Praetorius, Anna-Katharina; Eid, Michael

2016-01-01

Multirater (multimethod, multisource) studies are increasingly applied in psychology. Eid and colleagues (2008) proposed a multilevel confirmatory factor model for multitrait-multimethod (MTMM) data combining structurally different and multiple independent interchangeable methods (raters). In many studies, however, different interchangeable raters (e.g., peers, subordinates) are asked to rate different targets (students, supervisors), leading to violations of the independence assumption and to cross-classified data structures. In the present work, we extend the ML-CFA-MTMM model by Eid and colleagues (2008) to cross-classified multirater designs. The new C4 model (Cross-Classified CTC[M-1] Combination of Methods) accounts for nonindependent interchangeable raters and enables researchers to explicitly model the interaction between targets and raters as a latent variable. Using a real data application, it is shown how credibility intervals of model parameters and different variance components can be obtained using Bayesian estimation techniques.

On Asymptotically Good Ramp Secret Sharing Schemes

NASA Astrophysics Data System (ADS)

Geil, Olav; Martin, Stefano; Martínez-Peñas, Umberto; Matsumoto, Ryutaroh; Ruano, Diego

Asymptotically good sequences of linear ramp secret sharing schemes have been intensively studied by Cramer et al. in terms of sequences of pairs of nested algebraic geometric codes. In those works the focus is on full privacy and full reconstruction. In this paper we analyze additional parameters describing the asymptotic behavior of partial information leakage and possibly also partial reconstruction giving a more complete picture of the access structure for sequences of linear ramp secret sharing schemes. Our study involves a detailed treatment of the (relative) generalized Hamming weights of the considered codes.

Programmable Multiple-Ramped-Voltage Power Supply

NASA Technical Reports Server (NTRS)

Ajello, Joseph M.; Howell, S. K.

1993-01-01

Ramp waveforms range up to 2,000 V. Laboratory high-voltage power-supply system puts out variety of stable voltages programmed to remain fixed with respect to ground or float with respect to ramp waveform. Measures voltages it produces with high resolution; automatically calibrates, zeroes, and configures itself; and produces variety of input/output signals for use with other instruments. Developed for use with ultraviolet spectrometer. Also applicable to control of electron guns in general and to operation of such diverse equipment used in measuring scattering cross sections of subatomic particles and in industrial electron-beam welders.

Coarse cross-bedded grainstones in a mid- to outer carbonate ramp, Bartonian of the Urbasa-Andia plateau (W Pyrenees, N Spain)

NASA Astrophysics Data System (ADS)

Baceta, José I.; Pomar, Luis; Mateu-Vicens, Guillem

2017-04-01

Most marine grainstones in carbonate ramps and platforms are commonly interpreted to form in high-energy, shallow-water settings where wave energy dissipates by friction on the sea floor. The locus of energy dissipation varies with platform type. On rimmed shelves, skeletal-oolitic sands mainly accumulate near the wave-agitated shelf margin as a rim, which restricts wave action and a low-energy lagoon may form landwards. On ramps and open platforms, by contrast, grainstones commonly accumulate in the shallower zone near or attached to the shoreline, grading basinward into muddier carbonate successions. Within this conceptual scheme, most carbonate ramp subdivisions have been established according to the facies and sedimentary structures associated to the bathymetry-related hydraulic regime, in which the bases of the surface storm-waves and the fairweather waves are the boundary layers. Since seagrasses encroached the oceans by the late Cretaceous, baffling the surface wave energy, and burrowing activity increased significantly, most Cenozoic ramp successions lack the bathymetry-related sedimentary structures and the record of wave and storm activity is commonly lost. This has induced ramp subdivision to become progressively based in light penetration, as inferred from the light dependence of the carbonate producers, particularly for the Cenozoic. This new scenario has permitted to recognize grainstone units detached from shoreline and shoals and produced at depths near the limit of light penetration, or even below, in basinal settings. Here we document a 90-100-m thick Eocene example of crossbedded skeletal grainstones composed by echinoderm-, bryozoan-, red-algal fragments and orthophragminid larger benthic foraminifers. This facies belt occurs at 20-km from the paleo-coastline, downdip of Nummulites-Discocyclina facies, and passes basinward into finely comminuted skeletal debris and marls with planktonic foraminifers of the outer ramp. The skeletal composition of the cross-bedded belt indicates carbonate production to have occurred near the lower limit of the light penetration, and hydraulic turbulence to rework the coarser sediments and winnow-away de fines at the transition between middle- and outer ramp. Bedform migration indicates two main flow directions: oblique upslope traction currents (run-up) and downslope backwash return flow. This indicates turbulence to be detached from the surface storm waves and suggests internal waves breaking obliquely to the slopping ramp. This example documents the potential role of internal waves in shaping and redistributing sediments across ancient carbonate ramp systems, producing porous bodies close to basinal facies. These grainstone bodies may become good targets but acquire special relevance when prediction of good drains is needed in both exploration and production of unconventional. ACKNOWLEDGEMENTS Funding from Ministerio de Economía y Competitividad Project CGL2014-52096-P is acknowledged. This is also a contribution to the Research Group of the Basque University System IT-930-16.

Changes of hydrodynamic parameters on mountain stream bed within the block ramp influence and possibility of their use for integrated river management

NASA Astrophysics Data System (ADS)

Radecki-Pawlik, Artur; Plesiński, Karol

2016-04-01

In modern river management practices and philosophy one can notice coming more into use ecological friendly hydraulic structures. Those, which are especially needed for river training works, as far as expectation of Water Framework Directive is concerned, are block ramps which are hydraulic structures working similar to riffles known very well from fluvial geomorphology studies and are natural features in streams and rivers. What is important well designed block ramps do not stop fish and invertebrates against migrating, provide natural and esthetical view being built within the river channel, still working as hydraulic engineering structures and might be used in river management in different river ecosystems. The main aim of the research was to describe changes of values of hydrodynamics parameters upstream and downstream of the block ramps and to find out their influence on hydrodynamics of the stream. The study was undertaken on the Porębianka River in the Gorce Mountains, Polish Carpathians. Observed hydrodynamic parameters within the reach of the block ramps depend on the location of measuring point and the influence of individual part of the structure. We concluded that: 1. Hydrodynamic parameters close to block ramps depend on the location of the measurement points in relation to particular elements of the structure; 2. The highest value of velocities don't cause the highest force values, which acting on the bed of the watercourse, because they are rather related to the water level of the channel; 3. The values of mean velocities, shear velocities and shear stresses were similar upstream and downstream the block ramps, which means that the structures stabilize the river bed. This study was performed within the scope of the Science Activity money from Ministry of High Education and Young Scientist's Activity Money of Department of Hydraulics Engineering and Geotechnique, University of Agriculture, Cracow, Poland

Evaluating the Functionality and Usability of Two Novel Wheelchair Anti-Rollback Devices for Ramp Ascent in Manual Wheelchair Users With Spinal Cord Injury.

PubMed

Deems-Dluhy, Susan L; Jayaraman, Chandrasekaran; Green, Steve; Albert, Mark V; Jayaraman, Arun

2017-05-01

Difficulty ascending ramps and inclines with a manual wheelchair adversely affects the everyday mobility and overall quality of life of manual wheelchair users. Currently, various anti-rollback devices are available to assist manual wheelchair users to ascend ramps and inclines. However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelchair, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp. To evaluate the functionality and usability of 2 novel wheelchair anti-rollback devices developed to address these shortcomings (prototypes "Wheel" and "Brake"). Cross-sectional. Rehabilitation research facility. Twelve adult participants with chronic spinal cord injury. Participants completed training and tested with both the wheelchair anti-rollback devices on a 7.3-m-long ramp. Number of stops, perceived physical exertion, pain, and ease of use of these devices as participants maneuvered their wheelchairs up a 7.3-m ramp were assessed. Participants also evaluated their satisfaction with the usability of both the devices using the Quebec User Evaluation of Satisfaction With Assistive Technology (QUEST 2.0). Both prototypes evaluated overcame the limitations of the existing anti-rollback devices. Nonparametric statistical tests showed that participants rated both prototypes similarly for the overall functional and usability aspects. However, the participants' satisfactory rating were higher for the prototype "Brake" than for the prototype "Wheel" based on a functional aspect (ie, engaging/disengaging easiness), and higher for Wheel than for Brake, based on a usability aspect (prototype size). The qualitative and quantitative outcomes of this investigation, based on the usability and functional evaluations, provided useful information for the improvement in the design of both anti-rollback devices, which may allow manual wheelchair users to manage ramp ascent more safely and easily. Further evaluations with a different SCI population is recommended. IV. Copyright © 2017 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Lifestyles of the palaeoproterozoic stromatolite builders in the Vempalle Sea, Cuddapah Basin, India

NASA Astrophysics Data System (ADS)

Patranabis-Deb, Sarbani; Majumder, Tuasha; Khan, Sayani

2018-05-01

The distribution and changing pattern of stromatolites in the Vempalle Formation of the Cuddapah Basin, India, have been investigated with emphasis on external morphologies, internal fabrics, growth patterns and sediment associations. The stromatolitic limestone occurs in a low angle ramp type carbonate platform, with complete exposures from shallow shelf to basinal facies, provides record of changes in reef-building capacity of stromatolites with change in the depositional milieu. Changing pattern and style of the stromatolites clearly reflect depth partitioned growth of the microbial community. Small and scattered stromatolites, commonly with wavy parallel laminations or stratifications occurred in inner-ramp settings, where they are build up to the sea level. Tepee structure and desiccation cracks in associated sediments and salt pseudomorphs point to shallow water to occasional exposure condition. Large bioherms with columnar and conical stromatolites developed in the headland (mid ramp), which were in continuous interaction with strong waves of the open sea. Growth of the bioherms changed the landform with time and generated a high sloping edge with a sheer drop that extended out into the sea, forming distally steepened ramp. Outer ramp lithofacies characterized by thick layers of shale succession with thin beds of laterally persistent stromatolitic beds with low synoptic relief build-ups. These biotic components, along with the absence of wave-related structures, place the outer ramp below the base of wave action zone. Ooid banks developed in the mid ramp area are in the high surfing zone. High flux of nutrients and high-light show positive correlation; thus the high growth pattern is best observed within the photic zone where wave action is maximum. The ability to change from low synoptic relief algal laminites to high synoptic relief columnar stromatolites point to their adaptive power. The key factor that controlled the shape of these Palaeoproterozoic stromatolites is the dynamic interactions between mat growth, currents and sediment supply. Presence of concentric and radial fibrous ooids indicates change in climate and salinity of the sea.

Validating the energy transport modeling of the DIII-D and EAST ramp up experiments using TSC

NASA Astrophysics Data System (ADS)

Liu, Li; Guo, Yong; Chan, Vincent; Mao, Shifeng; Wang, Yifeng; Pan, Chengkang; Luo, Zhengping; Zhao, Hailin; Ye, Minyou

2017-06-01

The confidence in ramp up scenario design of the China fusion engineering test reactor (CFETR) can be significantly enhanced using validated transport models to predict the current profile and temperature profile. In the tokamak simulation code (TSC), two semi-empirical energy transport models (the Coppi-Tang (CT) and BGB model) and three theory-based models (the GLF23, MMM95 and CDBM model) are investigated on the CFETR relevant ramp up discharges, including three DIII-D ITER-like ramp up discharges and one EAST ohmic discharge. For the DIII-D discharges, all the transport models yield dynamic {{\\ell}\\text{i}} within +/- 0.15 deviations except for some time points where the experimental fluctuation is very strong. All the models agree with the experimental {β\\text{p}} except that the CT model strongly overestimates {β\\text{p}} in the first half of ramp up phase. When applying the CT, CDBM and GLF23 model to estimate the internal flux, they show maximum deviations of more than 10% because of inaccuracies in the temperature profile predictions, while the BGB model performs best on the internal flux. Although all the models fall short in reproducing the dynamic {{\\ell}\\text{i}} evolution for the EAST tokamak, the result of the BGB model is the closest to the experimental {{\\ell}\\text{i}} . Based on these comparisons, we conclude that the BGB model is the most consistent among these models for simulating CFETR ohmic ramp-up. The CT model with improvement for better simulation of the temperature profiles in the first half of ramp up phase will also be attractive. For the MMM95, GLF23 and CDBM model, better prediction of the edge temperature will improve the confidence for CFETR L-mode simulation. Conclusive validation of any transport model will require extensive future investigation covering a larger variety discharges.

Effects of the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) on biomedical outcomes, observed cardiovascular events and cardiovascular risks in primary care: a longitudinal comparative study.

PubMed

Jiao, Fang Fang; Fung, Colman Siu Cheung; Wong, Carlos King Ho; Wan, Yuk Fai; Dai, Daisy; Kwok, Ruby; Lam, Cindy Lo Kuen

2014-08-21

To assess whether the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) led to improvements in biomedical outcomes, observed cardiovascular events and predicted cardiovascular risks after 12-month intervention in the primary care setting. A random sample of 1,248 people with diabetes enrolled to RAMP-DM for at least 12 months was selected and 1,248 people with diabetes under the usual primary care were matched by age, sex, and HbA1c level at baseline as the usual care group. Biomedical and cardiovascular outcomes were measured at baseline and at 12-month after the enrollment. Difference-in-differences approach was employed to measure the effect of RAMP-DM on the changes in biomedical outcomes, proportion of subjects reaching treatment targets, observed and predicted cardiovascular risks. Compared to the usual care group, RAMP-DM group had lower cardiovascular events incidence (1.21% vs 2.89%, P = 0.003), and net decrease in HbA1c (-0.20%, P < 0.01), SBP (-3.62 mmHg, P < 0.01) and 10-year cardiovascular disease (CVD) risks (total CVD risk, -2.06%, P < 0.01; coronary heart disease (CHD) risk, -1.43%, P < 0.01; stroke risk, -0.71%, P < 0.01). The RAMP-DM subjects witnessed significant rises in the proportion of reaching treatment targets of HbA1c, and SBP/DBP. After adjusting for confounding variables, the significance remained for HbA1c, predicted CHD and stroke risks. The RAMP-DM resulted in greater improvements in HbA1c and reduction in observed and predicted cardiovascular risks at 12 months follow-up, which indicated a risk-stratification multidisciplinary intervention was an effective strategy for managing Chinese people with diabetes in the primary care setting. ClinicalTrials.gov, NCT02034695.

Climatological attribution of wind power ramp events in East Japan and their probabilistic forecast based on multi-model ensembles downscaled by analog ensemble using self-organizing maps

NASA Astrophysics Data System (ADS)

Ohba, Masamichi; Nohara, Daisuke; Kadokura, Shinji

2016-04-01

Severe storms or other extreme weather events can interrupt the spin of wind turbines in large scale that cause unexpected "wind ramp events". In this study, we present an application of self-organizing maps (SOMs) for climatological attribution of the wind ramp events and their probabilistic prediction. The SOM is an automatic data-mining clustering technique, which allows us to summarize a high-dimensional data space in terms of a set of reference vectors. The SOM is applied to analyze and connect the relationship between atmospheric patterns over Japan and wind power generation. SOM is employed on sea level pressure derived from the JRA55 reanalysis over the target area (Tohoku region in Japan), whereby a two-dimensional lattice of weather patterns (WPs) classified during the 1977-2013 period is obtained. To compare with the atmospheric data, the long-term wind power generation is reconstructed by using a high-resolution surface observation network AMeDAS (Automated Meteorological Data Acquisition System) in Japan. Our analysis extracts seven typical WPs, which are linked to frequent occurrences of wind ramp events. Probabilistic forecasts to wind power generation and ramps are conducted by using the obtained SOM. The probability are derived from the multiple SOM lattices based on the matching of output from TIGGE multi-model global forecast to the WPs on the lattices. Since this method effectively takes care of the empirical uncertainties from the historical data, wind power generation and ramp is probabilistically forecasted from the forecasts of global models. The predictability skill of the forecasts for the wind power generation and ramp events show the relatively good skill score under the downscaling technique. It is expected that the results of this study provides better guidance to the user community and contribute to future development of system operation model for the transmission grid operator.

4. Threequarter view of Asylum (Western) Avenue viaduct and ramp ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Three-quarter view of Asylum (Western) Avenue viaduct and ramp on southeast corner of bridge, facing northwest. - Asylum Avenue Viaduct, Spanning Second Creek & Southern Railroad at State Route 62, Knoxville, Knox County, TN

15. FIGUEROA STREET NORTHBOUND EXIT RAMP UNDER SOUTHBOUND LANES. UPPER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. FIGUEROA STREET NORTHBOUND EXIT RAMP UNDER SOUTHBOUND LANES. UPPER LEVEL IS INTERSTATE 1-5. LOOKING 162° SSE. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

X-36 on Ramp Viewed from Above

NASA Image and Video Library

1997-07-16

This look-down view of the X-36 Tailless Fighter Agility Research Aircraft on the ramp at NASA’s Dryden Flight Research Center, Edwards, California, clearly shows the unusual wing and canard design of the remotely-piloted aircraft.

South view; Interior view of covered ramp to Street Car ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

South view; Interior view of covered ramp to Street Car Waiting House from Station Building - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

North view; Interior view of covered ramp to Station Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North view; Interior view of covered ramp to Station Building from Street Car Waiting House - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

West view, general; Station Building, covered ramp, and Street Car ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West view, general; Station Building, covered ramp, and Street Car Waiting House, right to left - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

An Evaluation of detectable warning surfaces for sidewalk curb ramps.

DOT National Transportation Integrated Search

1995-01-01

The 1991 Americans with Disabilities Act Accessibility Guidelines required the installation of a detectable warning surface (raised truncated domes) on sidewalk curb ramps to alert visually impaired people to potential hazards. Although this requirem...

Facility S 372, replacement dolphins and ramp from upper deck ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Facility S 372, replacement dolphins and ramp from upper deck of ferry boat (YFB 87). - U.S. Naval Base, Pearl Harbor, Ferry Landing Type, Halawa Landing on Ford Island, Pearl City, Honolulu County, HI

Dynamics of the outgoing turbulent boundary layer in a Mach 5 unswept compression ramp interaction

NASA Technical Reports Server (NTRS)

Gramann, Richard A.; Dolling, David S.

1990-01-01

Wall pressure fluctuations have been measured under the unsteady separation shock and on the ramp face in an unswept Mach 5 compression ramp interaction. The freestream Reynolds number was 51.0 x 10 to the 6th/m, and the incoming turbulent boundary layer developed on the tunnel floor under approximately adiabatic wall temperature conditions. Standard data-acquisition methods, as well as real-time and posttest conditional sampling techniques were used. The results show that the mean and rms pressure levels are strong functions of separation shock position. At all stations on the ramp, from the corner to where the pressure reaches the theoretical inviscid value, the pressure signals have two dominant components: a low frequency component characteristic of the global unsteadiness, which correlates with the separation shock motion, and a higher frequency component associated with turbulence. The former is the major contributor to the overall signal variance.

Motor power factor controller with a reduced voltage starter

NASA Technical Reports Server (NTRS)

Nola, F. J. (Inventor)

1981-01-01

A power factor type motor controller is disclosed in which the conventional power factor constant voltage command signal is replaced during a starting interval with a graduated control voltage. This continuation-impart of a pending patent application (Serial No. 199, 765: Three Phase Factor Controller) provides a means for modifying the operation of the system for a motor start-up interval of 5 to 30 second. Using a ramp generators, an initial ramp-like signal replaces a constant power factor signal supplied by a potentiometer. The ramp-like signal is applied to a 15 terminal where it is summed with an operating power factor signal from phase detectors in order to obtain a control signal for ultimately controlling SCR devices. The SCR devices are turned on at an advancing rate with time responsive to the combination signal described rather than simply a function of a ramp-like signal alone.

Interactive computer graphics applications for compressible aerodynamics

NASA Technical Reports Server (NTRS)

Benson, Thomas J.

1994-01-01

Three computer applications have been developed to solve inviscid compressible fluids problems using interactive computer graphics. The first application is a compressible flow calculator which solves for isentropic flow, normal shocks, and oblique shocks or centered expansions produced by two dimensional ramps. The second application couples the solutions generated by the first application to a more graphical presentation of the results to produce a desk top simulator of three compressible flow problems: 1) flow past a single compression ramp; 2) flow past two ramps in series; and 3) flow past two opposed ramps. The third application extends the results of the second to produce a design tool which solves for the flow through supersonic external or mixed compression inlets. The applications were originally developed to run on SGI or IBM workstations running GL graphics. They are currently being extended to solve additional types of flow problems and modified to operate on any X-based workstation.

Micro-Ramp Flow Control for Oblique Shock Interactions: Comparisons of Computational and Experimental Data

NASA Technical Reports Server (NTRS)

Hirt, Stephanie M.; Reich, David B.; O'Connor, Michael B.

2012-01-01

Computational fluid dynamics was used to study the effectiveness of micro-ramp vortex generators to control oblique shock boundary layer interactions. Simulations were based on experiments previously conducted in the 15- by 15-cm supersonic wind tunnel at the NASA Glenn Research Center. Four micro-ramp geometries were tested at Mach 2.0 varying the height, chord length, and spanwise spacing between micro-ramps. The overall flow field was examined. Additionally, key parameters such as boundary-layer displacement thickness, momentum thickness and incompressible shape factor were also examined. The computational results predicted the effects of the microramps well, including the trends for the impact that the devices had on the shock boundary layer interaction. However, computing the shock boundary layer interaction itself proved to be problematic since the calculations predicted more pronounced adverse effects on the boundary layer due to the shock than were seen in the experiment.

Three-dimensional supersonic flow around double compression ramp with finite span

NASA Astrophysics Data System (ADS)

Lee, H. S.; Lee, J. H.; Park, G.; Park, S. H.; Byun, Y. H.

2017-01-01

Three-dimensional flows of Mach number 3 around a double-compression ramp with finite span have been investigated numerically. Shadowgraph visualisation images obtained in a supersonic wind tunnel are used for comparison. A three-dimensional Reynolds-averaged Navier-Stokes solver was used to obtain steady numerical solutions. Two-dimensional numerical results are also compared. Four different cases were studied: two different second ramp angles of 30° and 45° in configurations with and without sidewalls, respectively. Results showed that there is a leakage of mass and momentum fluxes heading outwards in the spanwise direction for three-dimensional cases without sidewalls. The leakage changed the flow characteristics of the shock-induced boundary layer and resulted in the discrepancy between the experimental data and two-dimensional numerical results. It is found that suppressing the flow leakage by attaching the sidewalls enhances the two-dimensionality of the experimental data for the double-compression ramp flow.

Fault-controlled pluton emplacement in the Sevier fold-and-thrust belt of southwest Montana, USA

NASA Astrophysics Data System (ADS)

Kalakay, Thomas J.; John, Barbara E.; Lageson, David R.

2001-06-01

Problems associated with syncompressional pluton emplacement center on the need to make room for magma in environments where crustal shortening, not extension, occurs on a regional scale. New structural data from the Pioneer and Boulder batholiths of southwest Montana, USA, suggest emplacement at the top of frontal thrust ramps as composite tabular bodies at crustal depths between 1 and 10 km. Frontal thrust facilitated pluton emplacement was accommodated by: (1) a magma feeder zone created along the ramp interface; (2) providing 'releasing steps' at ramp tops that serve as initial points of emplacement and subsequent pluton growth; and (3) localizing antithetic back-thrusts that assist in pluton ascent. A model of magma emplacement is proposed that involves these elements. This model for syntectonic ramp-top emplacement of plutons helps explain how space is made for plutons within fold-and-thrust belts.

Spin-Flipping Polarized Deuterons At COSY

NASA Astrophysics Data System (ADS)

Yonehara, K.; Krisch, A. D.; Morozov, V. S.; Raymond, R. S.; Wong, V. K.; Bechstedt, U.; Gebel, R.; Lehrach, A.; Lorenz, B.; Maier, R.; Prasuhn, D.; Schnase, A.; Stockhorst, H.; Eversheim, D.; Hinterberger, F.; Rohdjess, H.; Ulbrich, K.; Scobel, W.

2004-02-01

We recently stored a 1.85 GeV/c vertically polarized deuteron beam in the COSY Ring in Jülich; we then spin-flipped it by ramping a new air-core rf dipole's frequency through an rf-induced spin resonance to manipulate the polarization direction of the deuteron beam. We first experimentally determined the resonance's frequency and set the dipole's rf voltage to its maximum; then we varied its frequency ramp time and frequency range. We used the EDDA detector to measure the vector and tensor polarization asymmetries. We have not yet extracted the deuteron's tensor polarization spin-flip parameters from the measured data, since our short run did not provide adequate tensor analyzing-power data at 1.85 GeV/c. However, with a 100 Hz frequency ramp and our longest ramp time of 400 s, the deuterons' vector polarization spin-flip efficiency was 48±1%.

Freeway operations analysis of I-80 to I-29 interchange.

DOT National Transportation Integrated Search

1974-01-01

At the request of the Iowa State Highway Commission, the Engineering Research Institute observed the traffic operations at the Interstate 29 (1-29) and Interstate 80 (1-80) interchange in the southwest part of Council Bluffs.

Concurrent flow lanes - phase III.

DOT National Transportation Integrated Search

2011-01-01

This report describes efforts taken to develop and calibrate VISSIM models of existing : concurrent flow lane designs of north- and southbound lanes of I-270 from the interchange at : I-70 to interchanges on I-495 at Connecticut Avenue in Maryland an...

Safety evaluation of diverging diamond interchanges in Missouri.

DOT National Transportation Integrated Search

2015-01-01

The Diverging Diamond Interchange (DDI) has gained in popularity in the United States during the last decade. The : operational benefits and lower costs of retrofitting a conventional diamond with a DDI have contributed to its increased use. : Existi...

49 CFR Appendix A to Part 564 - Information to be Submitted for Replaceable Light Sources

Code of Federal Regulations, 2013 CFR

2013-10-01

..., and any other interchangeability dimensions for indexing the bulb base in the bulb holder. B. Diameter..., diameters, key/keyway sizes, and any other interchangeability dimensions for indexing the bulb base in the...

49 CFR Appendix A to Part 564 - Information to be Submitted for Replaceable Light Sources

Code of Federal Regulations, 2014 CFR

2014-10-01

..., and any other interchangeability dimensions for indexing the bulb base in the bulb holder. B. Diameter..., diameters, key/keyway sizes, and any other interchangeability dimensions for indexing the bulb base in the...

49 CFR Appendix A to Part 564 - Information To Be Submitted for Replaceable Light Sources

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and any other interchangeability dimensions for indexing the bulb base in the bulb holder. B. Diameter..., diameters, key/keyway sizes, and any other interchangeability dimensions for indexing the bulb base in the...

49 CFR Appendix A to Part 564 - Information To Be Submitted for Replaceable Light Sources

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and any other interchangeability dimensions for indexing the bulb base in the bulb holder. B. Diameter..., diameters, key/keyway sizes, and any other interchangeability dimensions for indexing the bulb base in the...

49 CFR Appendix A to Part 564 - Information To Be Submitted for Replaceable Light Sources

Code of Federal Regulations, 2012 CFR

2012-10-01

..., and any other interchangeability dimensions for indexing the bulb base in the bulb holder. B. Diameter..., diameters, key/keyway sizes, and any other interchangeability dimensions for indexing the bulb base in the...

UDOT diverging diamond interchange (DDI) observations and experience.

DOT National Transportation Integrated Search

2012-04-01

This report presents the results of a functionality evaluation, by the I-15 Utah County Corridor Expansion (CORE) traffic team, of the first Diverging Diamond Interchange (DDI) in Utah, located at the intersection of American Fork Main Street (Pionee...

Ethnoecology of the interchange of wild and weedy plants and mushrooms in Phurépecha markets of Mexico: economic motives of biotic resources management.

PubMed

Farfán-Heredia, Berenice; Casas, Alejandro; Moreno-Calles, Ana I; García-Frapolli, Eduardo; Castilleja, Aída

2018-01-15

Interactions between societies and nature are regulated by complex systems of beliefs, symbolism, customs, and worldviews (kosmos), ecological knowledge (corpus), and management strategies and practices (praxis), which are constructed as product of experiences and communication of people throughout time. These aspects influence social relations, life strategies, and cultural identity, and all of them in turn influence and are influenced by local and regional patterns of interchange. In this study, we analyze the interchange of wild and weedy plants and mushrooms in traditional markets of the Phurépecha region of Mexico. Particularly, the social relations constructed around the interchange of these products; how knowledge, cultural values, and ecological factors influence and are influenced by interchange; and how all these factors influence the type and intensity of biotic resources management. We studied three main traditional markets of the Phurépecha region of Michoacán, Mexico, through 140 visits to markets and 60 semi-structured interviews to sellers of wild and weedy plants and mushrooms. In nearly 2 years, we carried out 80 visits and 30 interviews in the "Barter Market", 20 visits and 15 interviews in the "Phurépecha Tiánguis", and 40 visits and 15 interviews to the "Municipal Market". We documented information about the spaces of interchange that form the markets, the types of interchange occurring there, the cultural and economic values of the resources studied, the environmental units that are sources of such resources, the activities associated to resources harvesting and, particularly, the management techniques practiced to ensure or increase their availability. We analyzed the relations between the amounts of products interchanged, considered as pressures on the resources; the perception of their abundance or scarcity, considered as the magnitude of risk in relation to the pressures referred to; and the management types as response to pressures and risk. We recorded 38 species of wild and weedy plants and 15 mushroom species interchanged in the markets. We characterized the spaces of interchange, the interchange types, and social relations among numerous Phurépecha communities which maintain the main features of pre-Columbian markets. The products analyzed are differentially valued according to their role in people's life, particularly food, medicine, rituals, and ornamental purposes. The highest cultural values were identified in multi-purpose plant and mushroom resources and, outstandingly, in ornamental and ritual plants. In markets, women are the main actors and connectors of the regional households' activities of use and management of local resources and ecosystems. The interrelationships between worldviews, knowledge, and practices are visible through the interchange of the products analyzed, including the types of environments comprised in communitarian territories, agricultural calendars, and feasts. Those plants and mushrooms are highly valued but relatively scarce according to the demand on them receiving special attention and management practices directed to ensure or increase their availability. With the exception of most mushrooms and ornamental and ritual plants, which have high economic and cultural values, there are those that are relatively scarce and under high risk, but are obtained through simple gathering from the wild. Traditional markets are crucial part of the subsistence strategy of Phurépecha people based on the multiple use of resources and ecosystems at the local and regional levels. The markets influence social relations, cultural identity, and preservation of traditional knowledge and biodiversity. In general, the demand of products in markets enhances innovation and practices for ensuring or increasing their availability, particularly those that are naturally scarce. However, it was notorious that, althoug mushrooms and ritual plants have high demand and value in markets, most of them are obtained by simple gathering.

Simulation of profile evolution from ramp-up to ramp-down and optimization of tokamak plasma termination with the RAPTOR code

NASA Astrophysics Data System (ADS)

Teplukhina, A. A.; Sauter, O.; Felici, F.; Merle, A.; Kim, D.; the TCV Team; the ASDEX Upgrade Team; the EUROfusion MST1 Team

2017-12-01

The present work demonstrates the capabilities of the transport code RAPTOR as a fast and reliable simulator of plasma profiles for the entire plasma discharge, i.e. from ramp-up to ramp-down. This code focuses, at this stage, on the simulation of electron temperature and poloidal flux profiles using prescribed equilibrium and some kinetic profiles. In this work we extend the RAPTOR transport model to include a time-varying plasma equilibrium geometry and verify the changes via comparison with ATSRA code simulations. In addition a new ad hoc transport model based on constant gradients and suitable for simulations of L-H and H-L mode transitions has been incorporated into the RAPTOR code and validated with rapid simulations of the time evolution of the safety factor and the electron temperature over the entire AUG and TCV discharges. An optimization procedure for the plasma termination phase has also been developed during this work. We define the goal of the optimization as ramping down the plasma current as fast as possible while avoiding any disruptions caused by reaching physical or technical limits. Our numerical study of this problem shows that a fast decrease of plasma elongation during current ramp-down can help in reducing plasma internal inductance. An early transition from H- to L-mode allows us to reduce the drop in poloidal beta, which is also important for plasma MHD stability and control. This work shows how these complex nonlinear interactions can be optimized automatically using relevant cost functions and constraints. Preliminary experimental results for TCV are demonstrated.

The Effects of Using a Ramp and Elevator to Load and Unload Trailers on the Behavior and Physiology of Piglets

PubMed Central

McGlone, John; Sapkota, Avi

2014-01-01

Simple Summary Transport is a routine practice in the modern swine industry. Loading the pigs into trailers can be a novel and stressful experience for the animals. This study compared behaviors and physiological variables during and after loading using a ramp or elevator to determine which method is the least stressful to the pigs. Loading pigs by ramp appears to cause more stress than loading by elevator. Abstract Transport is an inevitable process in the modern U.S. swine industry. The loading process is a novel and potentially stressful experience. This study uses behavior, heart rate and leukocyte counts to compare stress one hour before, during and after loading via ramp or elevator. Piglets were held in a home pen (control (CON)), walked up and down an aisle (handled (HAN)), or walked to a truck and loaded via elevator (ELE) or ramp (RAM). Sitting, feeding and blood parameters did not show a significant treatment by time effect (p > 0.05). Standing behavior did not differ between CON and HAN piglets nor between RAM and ELE piglets (p > 0.05); however, CON and HAN piglets stood more than RAM and ELE piglets during treatment (p < 0.05). After treatment, drinking behavior was increased in RAM piglets (p < 0.05). The heart rate of ELE piglets decreased 6.3% after treatment; whereas the heart rate of RAM piglets remained elevated 2.4% (p < 0.05). In terms of heart rate, loading by elevator appears to be less stressful than loading by ramp. PMID:26480323

Mixed siliciclastic and carbonate sedimentation within Spar Mountain Member of Ste. Genevieve Limestone, Hamilton County, Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, M.J.; Pryor, W.A.

1985-02-01

The Spar Mountain Member of the Ste. Genevieve Limestone (middle Mississippian) in Hamilton County, Illinois, consists of 40-60 ft (12-18 m) of interbedded limestones, shales, and sandstones. Five cores and 1400 electric logs were used to delineate two shallowing-upward carbonate cycles and 2 major clastic pulses within the Spar Mountain. Eight lithofacies representing 6 depositional environments were identified. They are: (A) echinoderm-brachiopod dolostone to packstone (outer ramp), (B) ooid-peloidal grainstone (intermediate ramp), (C) skeletal grainstone (intermediate ramp), (D) ooid-molluscan-intraclastic wackestone to grainstone (inner ramp), (E) pelletal-skeletal wackestone (inner ramp), (F) quartzarenite (channelized nearshore), (G) quartz-sublithic arenite to wacke (delta platform),more » and (H) quartz mudstone (prodelta, delta platform). Deposition occurred on a southwest-dipping carbonate ramp, with siliciclastic sediments originating from the northeast. The sequence of facies and their inferred depositional environments record 2 major progradational episodes. Oolitic facies are interpreted to be of tidal-bar belt origin and quartzarenite facies are interpreted to be of delta-distributary channel origin. Their distribution is partially controlled by antecedent and syndepositional topography. Many of these paleotopographic highes are positive features today and yield pinch-out stratigraphic relationships. Paleogeographic reconstructions demonstrate that the primary control on facies distribution was the position of the delta proper along strike. However, depositional topography also influenced sedimentation, particularly in the sand-sized fraction. Using this concept, better prediction of underlying porous buildups (ooid shoals) is possible if thickness of the overlying siliciclastic is known. Within buildups, a complex diagenetic history complicates the distribution of porosity.« less

True Triaxial Experimental Study of Rockbursts Induced By Ramp and Cyclic Dynamic Disturbances

NASA Astrophysics Data System (ADS)

Su, Guoshao; Hu, Lihua; Feng, Xiating; Yan, Liubin; Zhang, Gangliang; Yan, Sizhou; Zhao, Bin; Yan, Zhaofu

2018-04-01

A modified rockburst testing system was utilized to reproduce rockbursts induced by ramp and cyclic dynamic disturbances with a low-intermediate strain rate of 2 × 10-3-5 × 10-3 s-1 in the laboratory. The experimental results show that both the ramp and cyclic dynamic disturbances play a significant role in inducing rockbursts. In the tests of rockbursts induced by a ramp dynamic disturbance, as the static stress before the dynamic disturbance increases, both the strength of specimens and the kinetic energy of the ejected fragments first increase and then decrease. In the tests of rockbursts induced by a cyclic dynamic disturbance, there exists a rockburst threshold of the static stress and the dynamic disturbance amplitude, and the kinetic energy of the ejected fragments first increases and then decreases as the cyclic dynamic disturbance frequency increases. The main differences between rockbursts induced by ramp dynamic disturbances and those induced by cyclic dynamic disturbances are as follows: the rockburst development process of the former is characterized by an impact failure feature, while that of the latter is characterized by a fatigue failure feature; the damage evolution curve of the specimen of the former has a leap-developing form with a significant catastrophic feature, while that of the latter has an inverted S-shape with a remarkable fatigue damage characteristic; the energy mechanism of the former involves the ramp dynamic disturbance giving extra elastic strain energy to rocks, while that of the latter involves the cyclic dynamic disturbance decreasing the ultimate energy storage capacity of rocks.

Kinematic analysis of the thoracic limb of healthy dogs during descending stair and ramp exercises.

PubMed

Kopec, Nadia L; Williams, Jane M; Tabor, Gillian F

2018-01-01

OBJECTIVE To compare the kinematics of the thoracic limb of healthy dogs during descent of stairs and a ramp with those during a trot across a flat surface (control). ANIMALS 8 privately owned dogs. PROCEDURES For each dog, the left thoracic limb was instrumented with 5 anatomic markers to facilitate collection of 2-D kinematic data during each of 3 exercises (descending stairs, descending a ramp, and trotting over a flat surface). The stair exercise consisted of 4 steps with a 35° slope. For the ramp exercise, a solid plank was placed over the steps to create a ramp with a 35° slope. For the flat exercise, dogs were trotted across a flat surface for 2 m. Mean peak extension, peak flexion, and range of movement (ROM) of the shoulder, elbow, and carpal joints were compared among the 3 exercises. RESULTS Mean ROM for the shoulder and elbow joints during the stair exercise were significantly greater than during the flat exercise. Mean peak extension of the elbow joint during the flat exercise was significantly greater than that during both the stair and ramp exercises. Mean peak flexion of the elbow joint during the stair exercise was significantly greater than that during the flat exercise. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that descending stairs may be beneficial for increasing the ROM of the shoulder and elbow joints of dogs. Descending stair exercises may increase elbow joint flexion, whereas flat exercises may be better for targeting elbow joint extension.

Sound exposure changes European seabass behaviour in a large outdoor floating pen: Effects of temporal structure and a ramp-up procedure.

PubMed

Neo, Y Y; Hubert, J; Bolle, L; Winter, H V; Ten Cate, C; Slabbekoorn, H

2016-07-01

Underwater sound from human activities may affect fish behaviour negatively and threaten the stability of fish stocks. However, some fundamental understanding is still lacking for adequate impact assessments and potential mitigation strategies. For example, little is known about the potential contribution of the temporal features of sound, the efficacy of ramp-up procedures, and the generalisability of results from indoor studies to the outdoors. Using a semi-natural set-up, we exposed European seabass in an outdoor pen to four treatments: 1) continuous sound, 2) intermittent sound with a regular repetition interval, 3) irregular repetition intervals and 4) a regular repetition interval with amplitude 'ramp-up'. Upon sound exposure, the fish increased swimming speed and depth, and swam away from the sound source. The behavioural readouts were generally consistent with earlier indoor experiments, but the changes and recovery were more variable and were not significantly influenced by sound intermittency and interval regularity. In addition, the 'ramp-up' procedure elicited immediate diving response, similar to the onset of treatment without a 'ramp-up', but the fish did not swim away from the sound source as expected. Our findings suggest that while sound impact studies outdoors increase ecological and behavioural validity, the inherently higher variability also reduces resolution that may be counteracted by increasing sample size or looking into different individual coping styles. Our results also question the efficacy of 'ramp-up' in deterring marine animals, which warrants more investigation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Roles of CLR/RAMP Receptor Signaling in Reproduction and Development

PubMed Central

Chang, Chia Lin; Hsu, Sheau Yu Teddy

2016-01-01

Adrenomedullin (ADM), calcitonin gene-related peptides (α- and β-CGRPs), and intermedin/adrenomedullin 2 (IMD/ADM2) are major regulators of vascular tone and cardiovascular development in vertebrates. Recent research into their functions in reproduction has illuminated the role of these peptides and their cognate receptors (calcitonin receptor-like receptor/receptor activity-modifying protein (CLR/RAMP) receptors) in fetal–maternal blood circulation, feto-placental development, female gamete development, and gamete movement in the oviduct. Although ADM family peptides function in a temporally and spatially specific manner in various reproductive processes, they appear to act via a similar set of second messengers, including nitric oxide, cyclic GMP, cyclic AMP, and calcium-activated potassium channels in different tissues. These discoveries supported the view that CLR/RAMP receptors were recruited to perform a variety of newly evolved reproductive functions during the evolution of internal reproduction in mammals. These advances also provided insight into how CLR/RAMP receptor signaling pathways coordinate with other physiological adaptions to accommodate the extra metabolic needs during pregnancy, and captured some important details as to how fetal–maternal vascular communications are generated in the first place. Furthermore, these findings have revealed novel, promising opportunities for the prevention and treatment of aberrant pregnancies such as pregnancy-induced hypertension, preeclampsia, and tubal ectopic pregnancy. However, significant efforts are still needed to clarify the relationships between certain components of the CLR/RAMP signaling pathway and aberrant pregnancies before CLR/RAMP receptors can become targets for clinical management. With this understanding, this review summarizes recent progresses with particular focus on clinical implications. PMID:23745703

Mechanisms of High-Temperature Fatigue Failure in Alloy 800H

NASA Technical Reports Server (NTRS)

BhanuSankaraRao, K.; Schuster, H.; Halford, G. R.

1996-01-01

The damage mechanisms influencing the axial strain-controlled Low-Cycle Fatigue (LCF) behavior of alloy 800H at 850 C have been evaluated under conditions of equal tension/compression ramp rates (Fast-Fast (F-F): 4 X 10(sup -3)/s and Slow-Slow (S-S): 4 X 10(sup -5)/s) and asymmetrical ramp rates (Fast-Slow (F-S): 4 x 10(sup -3)/s / 4 X 10(sup -5/s and Slow-Fast (S-F): 4 X 10(sup -5) / 4 X 10(sup -3)/s) in tension and compression. The fatigue life, cyclic stress response, and fracture modes were significantly influenced by the waveform shape. The fatigue lives displayed by different loading conditions were in the following order: F-F greater than S-S greater than F-S greater than S-F. The fracture mode was dictated by the ramp rate adopted in the tensile direction. The fast ramp rate in the tensile direction led to the occurrence of transgranular crack initiation and propagation, whereas the slow ramp rate caused intergranular initiation and propagation. The time-dependent processes and their synergistic interactions, which were at the basis of observed changes in cyclic stress response and fatigue life, were identified. Oxidation, creep damage, dynamic strain aging, massive carbide precipitation, time-dependent creep deformation, and deformation ratcheting were among the several factors influencing cyclic life. Irrespective of the loading condition, the largest effect on life was exerted by oxidation processes. Deformation ratcheting had its greatest influence on life under asymmetrical loading conditions. Creep damage accumulated the greatest amount during the slow tensile ramp under S-F conditions.

Kwik Bond Polymers(R) high friction surface treatment.

DOT National Transportation Integrated Search

2015-12-01

High friction surface treatment (HFST) was applied to two on-ramps in the Seattle urban area to improve : friction resistance. The ramps were high accident locations. The system applied was polyester resin binder and : calcined bauxite aggregate. Tes...

North side, showing ramp at western section but photograph taken ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North side, showing ramp at western section but photograph taken to east of CO-172-BR-8 and looking southwesterly. - Fitzsimons General Hospital, Infirmary, Northwest Corner of East Bushnell Avenue & South Page Street, Aurora, Adams County, CO

Field test implementation of queue control : final report.

DOT National Transportation Integrated Search

2011-12-01

A major challenge for implementing queue control has been to accurately estimate on-ramp queue lengths, particularly during saturated onramp : conditions, when the vehicle queue extends around or beyond the ramp entrance. The main outcome of the rese...

Line Operations Safety Assessments (LOSA) in Maintenance and Ramp Environments

DOT National Transportation Integrated Search

2017-01-01

Data-driven modifications to risk management are needed in maintenance and ramp environments to assist the Federal Aviation Administration (FAA) in the development of adequate tools/systems that increase safety by aiding the identification of hazards...

Ramp metering : procedure manual.

DOT National Transportation Integrated Search

2002-11-01

Ramp metering is a traffic management tool used to increase the efficiency and safety of the : traffic operations on freeways. It is one of the most cost effective ways of managing traffic flow. : It improves traffic flow on congested freeways and of...

Guidelines for the design and placement of curb ramps.

DOT National Transportation Integrated Search

1982-01-01

Information was obtained through surveys of ten state departments of transportation, four large U. S. cities, and eighteen departments of public works in Virginia. A sample inventory of curb ramps was made in 15 municipalities in Virginia. Interviews...

View east showing building 2 at left looking over seaplane ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View east showing building 2 at left looking over seaplane ramp area toward City of San Diego. - Naval Air Station North Island, Seaplane Ramps Nos. 2, 3 & 4, North Island, San Diego, San Diego County, CA

Preparing Solar Cells for Soldering

NASA Technical Reports Server (NTRS)

Hagerty, J. J.

1983-01-01

Solder paste and contact ribbon dispensed in synchronism. Solder-paste dispenser operates on one cell at a time. Ribbon fed up ramps and into positioned while solder paste is applied. When ramps are moved out of way, ribbon lies down onto cell.

97. VIEW OF PIER EXTENSION WITH RAMP IN FOREGROUND AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

97. VIEW OF PIER EXTENSION WITH RAMP IN FOREGROUND AND 4TH TEE IN BACKGROUND, LOOKING SOUTHWEST FROM 3RD TEE - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

A Coupled Model of Langmuir Circulations and Ramp-like Structures in the Upper Ocean Turbulent Boundary Layer

NASA Astrophysics Data System (ADS)

Soloviev, A.; Dean, C.; Lukas, R.; Donelan, M. A.; Terray, E. A.

2016-12-01

Surface-wave breaking is a powerful mechanism producing significant energy flux to small scale turbulence. Most of the turbulent energy produced by breaking waves dissipates within one significant wave height, while the turbulent diffusion layer extends to approximately ten significant wave heights. Notably, the near-surface shear may practically vanish within the wave-stirred layer due to small-scale turbulent mixing. The surface ocean temperature-salinity structure, circulation, and mass exchanges (including greenhouse gases and pollutants) substantially depend on turbulent mixing and non-local transport in the near-surface layer of the ocean. Spatially coherent organized motions have been recognized as an important part of non-local transport. Langmuir circulation (LC) and ramp-like structures are believed to vertically transfer an appreciable portion of the momentum, heat, gases, pollutants (e.g., oil), and other substances in the upper layer of the ocean. Free surface significantly complicates the analysis of turbulent exchanges at the air-sea interface and the coherent structures are not yet completely understood. In particular, there is growing observational evidence that in the case of developing seas when the wind direction may not coincide with the direction of the energy containing waves, the Langmuir lines are oriented in the wind rather than the wave direction. In addition, the vortex force due to Stokes drift in traditional models is altered in the breaking-wave-stirred layer. Another complication is that the ramp-like structures in the upper ocean turbulent boundary layer have axes perpendicular to the axes of LC. The ramp-like structures are not considered in the traditional model. We have developed a new model, which treats the LC and ramp-like structures in the near-surface layer of the ocean as a coupled system. Using computational fluid dynamics tools (LES), we have been able to reproduce both LC and ramp-like structures coexisting in space though intermittent in time. In the model, helicity isosurfaces appear to be tilted and, in general, coordinated with the tilted velocity isosurfaces produced by ramp-like structures. This is an indication of coupling between the LC and ramp-like structures. Remarkably, the new model is able to explain observations of LC under developing seas.

Does Stepwise Voltage Ramping Protect the Kidney from Injury During Extracorporeal Shockwave Lithotripsy? Results of a Prospective Randomized Trial.

PubMed

Skuginna, Veronika; Nguyen, Daniel P; Seiler, Roland; Kiss, Bernhard; Thalmann, George N; Roth, Beat

2016-02-01

Renal damage is more frequent with new-generation lithotripters. However, animal studies suggest that voltage ramping minimizes the risk of complications following extracorporeal shock wave lithotripsy (SWL). In the clinical setting, the optimal voltage strategy remains unclear. To evaluate whether stepwise voltage ramping can protect the kidney from damage during SWL. A total of 418 patients with solitary or multiple unilateral kidney stones were randomized to receive SWL using a Modulith SLX-F2 lithotripter with either stepwise voltage ramping (n=213) or a fixed maximal voltage (n=205). SWL. The primary outcome was sonographic evidence of renal hematomas. Secondary outcomes included levels of urinary markers of renal damage, stone disintegration, stone-free rate, and rates of secondary interventions within 3 mo of SWL. Descriptive statistics were used to compare clinical outcomes between the two groups. A logistic regression model was generated to assess predictors of hematomas. Significantly fewer hematomas occurred in the ramping group(12/213, 5.6%) than in the fixed group (27/205, 13%; p=0.008). There was some evidence that the fixed group had higher urinary β2-microglobulin levels after SWL compared to the ramping group (p=0.06). Urinary microalbumin levels, stone disintegration, stone-free rate, and rates of secondary interventions did not significantly differ between the groups. The logistic regression model showed a significantly higher risk of renal hematomas in older patients (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00-1.05; p=0.04). Stepwise voltage ramping was associated with a lower risk of hematomas (OR 0.39, 95% CI 0.19-0.80; p=0.01). The study was limited by the use of ultrasound to detect hematomas. In this prospective randomized study, stepwise voltage ramping during SWL was associated with a lower risk of renal damage compared to a fixed maximal voltage without compromising treatment effectiveness. Lithotripsy is a noninvasive technique for urinary stone disintegration using ultrasonic energy. In this study, two voltage strategies are compared. The results show that a progressive increase in voltage during lithotripsy decreases the risk of renal hematomas while maintaining excellent outcomes. ISRCTN95762080. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Controls on facies and sequence stratigraphy of an upper Miocene carbonate ramp and platform, Melilla basin, NE Morocco

USGS Publications Warehouse

Cunningham, K.J.; Collins, Luke S.

2002-01-01

Upwelling of cool seawater, paleoceanographic circulation, paleoclimate, local tectonics and relative sea-level change controlled the lithofacies and sequence stratigraphy of a carbonate ramp and overlying platform that are part of a temporally well constrained carbonate complex in the Melilla basin, northeastern Morocco. At Melilla, from oldest to youngest, a third-order depositional sequence within the carbonate complex contains (1) a retrogradational, transgressive, warm temperate-type rhodalgal ramp; (2) an early highstand, progradational, bioclastic platform composed mainly of a temperate-type, bivalve-rich molechfor facies; and (3) late highstand, progradational to downstepping, subtropical/tropical-type chlorozoan fringing Porites reefs. The change from rhodalgal ramp to molechfor platform occurred at 7.0??0.14 Ma near the Tortonian/Messinian boundary. During a late stage in the development of the bioclastic platform a transition from temperate-type molechfor facies to subtropical/tropical-type chlorozoan facies occurred and is bracketed by chron 3An.2n (??? 6.3-6.6 Ma). Comparison to a well-dated carbonate complex in southeastern Spain at Cabo de Gata suggests that upwelling of cool seawater influenced production of temperate-type limestone within the ramp and platform at Melilla during postulated late Tortonian-early Messinian subtropical/tropical paleoclimatic conditions in the western Paleo-Mediterranean region. The upwelling of cool seawater across the bioclastic platform at Melilla could be related to the beginning of 'siphoning' of deep, cold Atlantic waters into the Paleo-Mediterranean Sea at 7.17 Ma. The facies change within the bioclastic platform from molechfor to chlorozoan facies may be coincident with a reduction of the siphoning of Atlantic waters and the end of upwelling at Melilla during chron 3An.2n. The ramp contains one retrogradational parasequence and the bioclastic platform three progradational parasequences. Minor erosional surfaces that bound the upper surface of the ramp and upper surface of the oldest platform parasequence are related to relative falls in sea level induced by local volcanism and associated tectonic uplift. These local relative falls had little influence on a broader-scale rise to stillstand in relative sea level that controlled development of the transgressive and early highstand systems tracts represented in the ramp and platform, respectively. ?? 2002 Elsevier Science B.V. All rights reserved.

Comprehensive plan amendment impacts on interchanges in Oregon : final report.

DOT National Transportation Integrated Search

2005-09-01

This report examines the effects of amendments to local comprehensive plans on interchange performance on the Oregon highway system. Plan amendments over a 15-year period in Oregon, resulting in changes to industrial or commercial land use, were revi...

Crash location correction for freeway interchange modeling : final report.

DOT National Transportation Integrated Search

2016-06-01

AASHTO released a supplement to the Highway Safety Manual (HSM) in 2014 that includes models for freeway : interchanges composed of segments, speed-change lanes and terminals. A necessary component to the use of HSM is : having the appropriate safety...

Research notes : linking land use to traffic impacts at interchanges.

DOT National Transportation Integrated Search

2006-08-01

The objective of the research was to examine the effects of comprehensive plan amendments on interchange performance on the Oregon highway system. The focus of the study was on comprehensive plan amendments for new commercial and industrial land uses...

Collecting and Analyzing Stakeholder Feedback for Signing at Complex Interchanges

DOT National Transportation Integrated Search

2014-10-01

The purpose of this project was to identify design constraints related to signing, markings, and geometry for complex interchanges, and then to identify useful topics for future research that will yield findings that can address those design issues. ...

77 FR 14464 - Notice of Final Federal Agency Actions on Proposed Highway Project in Wisconsin

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... a proposed highway project, Interstate I-94, I-894, and U.S. Highway 45 (Zoo Interchange) in... project: Interstate I-94, I-894, and U.S. Highway 45 (Zoo Interchange) in Milwaukee County, Wisconsin...

Interchange Instability and Transport in Matter-Antimatter Plasmas

NASA Astrophysics Data System (ADS)

Kendl, Alexander; Danler, Gregor; Wiesenberger, Matthias; Held, Markus

2017-06-01

Symmetric electron-positron plasmas in inhomogeneous magnetic fields are intrinsically subject to interchange instability and transport. Scaling relations for the propagation velocity of density perturbations relevant to transport in isothermal magnetically confined electron-positron plasmas are deduced, including damping effects when Debye lengths are large compared to Larmor radii. The relations are verified by nonlinear full-F gyrofluid computations. Results are analyzed with respect to planned magnetically confined electron-positron plasma experiments. The model is generalized to other matter-antimatter plasmas. Magnetized electron-positron-proton-antiproton plasmas are susceptible to interchange-driven local matter-antimatter separation, which can impede sustained laboratory magnetic confinement.

Local regulation of interchange turbulence in a dipole-confined plasma torus using current-collection feedback

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, T. M., E-mail: tmr2122@columbia.edu; Mauel, M. E., E-mail: mauel@columbia.edu; Worstell, M. W.

2015-05-15

Turbulence in plasma confined by a magnetic dipole is dominated by interchange fluctuations with complex dynamics and short spatial coherence. We report the first use of local current-collection feedback to modify, amplify, and suppress these fluctuations. The spatial extent of turbulence regulation is limited to a correlation length near the collector. Changing the gain and phase of collection results in power either extracted from or injected into the turbulence. The measured plasma response shows some agreement with calculations of the linear response of global interchange-like MHD and entropy modes to current-collection feedback.

Interchange Instability and Transport in Matter-Antimatter Plasmas.

PubMed

Kendl, Alexander; Danler, Gregor; Wiesenberger, Matthias; Held, Markus

2017-06-09

Symmetric electron-positron plasmas in inhomogeneous magnetic fields are intrinsically subject to interchange instability and transport. Scaling relations for the propagation velocity of density perturbations relevant to transport in isothermal magnetically confined electron-positron plasmas are deduced, including damping effects when Debye lengths are large compared to Larmor radii. The relations are verified by nonlinear full-F gyrofluid computations. Results are analyzed with respect to planned magnetically confined electron-positron plasma experiments. The model is generalized to other matter-antimatter plasmas. Magnetized electron-positron-proton-antiproton plasmas are susceptible to interchange-driven local matter-antimatter separation, which can impede sustained laboratory magnetic confinement.

A new cryogenic diode thermometer

NASA Astrophysics Data System (ADS)

Courts, S. S.; Swinehart, P. R.; Yeager, C. J.

2002-05-01

While the introduction of yet another cryogenic diode thermometer is not earth shattering, a new diode thermometer, the DT-600 series, recently introduced by Lake Shore Cryotronics, possesses three features that make it unique among commercial diode thermometers. First, these diodes have been probed at the chip level, allowing for the availability of a bare chip thermometer matching a standard curve-an important feature in situations where real estate is at a premium (IR detectors), or where in-situ calibration is difficult. Second, the thermometry industry has assumed that interchangeability should be best at low temperatures. Thus, good interchangeability at room temperatures implies a very good interchangeability at cryogenic temperature, resulting in a premium priced sensor. The DT-600 series diode thermometer is available in an interchangeability band comparable to platinum RTDs with the added advantage of interchangeability to 2 K. Third, and most important, the DT-600 series diode does not exhibit an instability in the I-V characteristic in the 8 K to 20 K temperature range that is observed in other commercial diode thermometer devices [1]. This paper presents performance characteristics for the DT-600 series diode thermometer along with a comparison of I-V curves for this device and other commercial diode thermometers exhibiting an I-V instability.

Dynamics of Coronal Hole Boundaries

NASA Technical Reports Server (NTRS)

Higginson, A. K.; Antiochos, S. K.; DeVore, C. R.; Wyper, Peter F.; Zurbuchen, T. H.

2017-01-01

Remote and in situ observations strongly imply that the slow solar wind consists of plasma from the hot, closed-field corona that is released onto open magnetic field lines. The Separatrix Web theory for the slow wind proposesthat photospheric motions at the scale of supergranules are responsible for generating dynamics at coronal-holeboundaries, which result in the closed plasma release. We use three-dimensional magnetohydrodynamicsimulations to determine the effect of photospheric flows on the open and closed magnetic flux of a model coronawith a dipole magnetic field and an isothermal solar wind. A rotational surface motion is used to approximatephotospheric supergranular driving and is applied at the boundary between the coronal hole and helmet streamer.The resulting dynamics consist primarily of prolific and efficient interchange reconnection between open andclosed flux. The magnetic flux near the coronal-hole boundary experiences multiple interchange events, with someflux interchanging over 50 times in one day. Additionally, we find that the interchange reconnection occurs allalong the coronal-hole boundary and even produces a lasting change in magnetic-field connectivity in regions thatwere not driven by the applied motions. Our results show that these dynamics should be ubiquitous in the Sun andheliosphere. We discuss the implications of our simulations for understanding the observed properties of the slowsolar wind, with particular focus on the global-scale consequences of interchange reconnection.

An O([Formula: see text]) algorithm for sorting signed genomes by reversals, transpositions, transreversals and block-interchanges.

PubMed

Yu, Shuzhi; Hao, Fanchang; Leong, Hon Wai

2016-02-01

We consider the problem of sorting signed permutations by reversals, transpositions, transreversals, and block-interchanges. The problem arises in the study of species evolution via large-scale genome rearrangement operations. Recently, Hao et al. gave a 2-approximation scheme called genome sorting by bridges (GSB) for solving this problem. Their result extended and unified the results of (i) He and Chen - a 2-approximation algorithm allowing reversals, transpositions, and block-interchanges (by also allowing transversals) and (ii) Hartman and Sharan - a 1.5-approximation algorithm allowing reversals, transpositions, and transversals (by also allowing block-interchanges). The GSB result is based on introduction of three bridge structures in the breakpoint graph, the L-bridge, T-bridge, and X-bridge that models goodreversal, transposition/transreversal, and block-interchange, respectively. However, the paper by Hao et al. focused on proving the 2-approximation GSB scheme and only mention a straightforward [Formula: see text] algorithm. In this paper, we give an [Formula: see text] algorithm for implementing the GSB scheme. The key idea behind our faster GSB algorithm is to represent cycles in the breakpoint graph by their canonical sequences, which greatly simplifies the search for these bridge structures. We also give some comparison results (running time and computed distances) against the original GSB implementation.

Guidelines Curb Cuts and Ramps for Disabled Persons

DOT National Transportation Integrated Search

1995-07-01

These guidelines for curb ramps were developed as part of an overall program of action to remove the restrictive barriers which severely impede the daily movements of physically handicapped and elderly persons. The common curb is probably the most en...

View of Facility No. S359 (Seaplane Ramp 3), with Koolau ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of Facility No. S359 (Seaplane Ramp 3), with Koolau Mountain Range in background - U.S. Naval Base, Pearl Harbor, Seaplane Runways-1933 Type, South shore of Ford Island, near Lexington Boulevard, Pearl City, Honolulu County, HI

8. REINFORCED CONCRETE SLAB ROOF FROM NORTHWEST EDGE, ACCESS RAMP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. REINFORCED CONCRETE SLAB ROOF FROM NORTHWEST EDGE, ACCESS RAMP IN FOREGROUND, VIEW TOWARDS SOUTHEAST. - Glenn L. Martin Company, Titan Missile Test Facilities, CaptiveTest Stand D-3, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

Wrong-way driving at selected interstate off-ramps.

DOT National Transportation Integrated Search

1980-01-01

This study was designed to evaluate, on interstate roadways in Virginia, the use of a technique developed in California for estimating or determining incidences of wrong-way driving at off-ramps. Also, information gained from a survey of the availabl...

Durability of truncated dome warnings on existing curb ramps : final report.

DOT National Transportation Integrated Search

2004-12-01

In 2002 the Federal Highway Administration (FHWA) notified the Oregon Department of Transportation (ODOT) that that the state was required to use truncated dome detectable warnings on curb ramps. Products appropriate for use on cured concrete surface...

Facility 596, detail of ramp from below, with replacement sheetpile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Facility 596, detail of ramp from below, with replacement sheet-pile dolphin on right and southernmost dolphins in background. - U.S. Naval Base, Pearl Harbor, Ferry Landing Type, Halawa Landing on Ford Island, Pearl City, Honolulu County, HI

Classification and Surgical Repair of Ramp Lesions of the Medial Meniscus.

PubMed

Thaunat, Mathieu; Fayard, Jean Marie; Guimaraes, Tales M; Jan, Nicolas; Murphy, Colin G; Sonnery-Cottet, Bertrand

2016-08-01

Ramp lesions of the medial meniscus are commonly associated with anterior cruciate ligament ruptures and consist of longitudinal peripheral tears of the posterior horn of the medial meniscus. Given the frequency of partial-thickness tears, they can be difficult to diagnose arthroscopically from the anterior compartment. We describe a classification of the different types of ramp lesions depending on both tear pattern (partial- or full-thickness tear) and associated meniscotibial ligament disruption. An original technique of arthroscopic suture placement through a single posteromedial portal with a 25° curved suture hook device is described.

Letter: Transient interaction between plasma jet and supersonic compression ramp flow

NASA Astrophysics Data System (ADS)

Huang, He-Xia; Tan, Hui-Jun; Sun, Shu; Zhang, Yu-Chao; Cheng, Lin

2018-04-01

The rapid flow evolution between a plasma jet and a 20° compression ramp flow is captured by a high-speed schlieren system at Mach 2.0. Several interesting flow phenomena are observed for the first time. The pulsed jet, which generates strong perturbations, forces the crossflow boundary layer to separate and forms a forward moving shock. A typical shock-on-shock interaction occurs when the precursor shock intersects with the original shock. The interaction is initially regular, and then it transforms into an irregular one with a Mach stem connecting the precursor shock and original ramp shock.

APPALACHIAN FOLDS, LATERAL RAMPS, AND BASEMENT FAULTS: A MODERN ENGINEERING PROBLEM?

USGS Publications Warehouse

Pohn, Howard A.

1987-01-01

Field studies and analysis of radar data have shown that cross-strike faulting in the central and southern Appalachians has affected geologic structures at the surface. These basement faults appear to have been active through much of geologic time. Indeed, more than 45 percent of modern earthquakes occur along these narrow zones here termed 'lateral ramps. ' Because of this seismic activity, these lateral ramps are likely to be zones that are prone to slope failure. The engineer should be aware of the presence of such zones and the higher landslide potential along them.

Design, fabrication, installation and flight service evaluation of a composite cargo ramp skin on a model CH-53 helicopter

NASA Technical Reports Server (NTRS)

Lowry, D. W.; Rich, M. J.

1983-01-01

The installation of a composite skin panel on the cargo ramp of a CH-530 marine helicopter is discussed. The composite material is of Kevlar/Epoxy (K/E) which replaces aluminum outer skins on the aft two bays of the ramp. The cargo ramp aft region was selected as being a helicopter airframe surface subjected to possible significant field damage and would permit an evaluation of the long term durability of the composite skin panel. A structural analysis was performed and the skin shears determined. Single lap joints of K/E riveted to aluminum were statically tested. The joint tests were used to determine bearing allowables and the required K/E skin gage. The K/E skin panels riveted to aluminum edge members were tested in a shear fixture to confirm the allowable shear and bearing strengths. Impact tests were conducted on aluminum skin panels to determine energy level and damage relationship. The K/E skin panels of various ply orientations and laminate thicknesses were then impacted at similar energy levels. The results of the analysis and tests were used to determine the required K/E skin gages in each of the end two bays of the ramp.

Ramp Creek and Harrodsburg Limestones: A shoaling-upward sequence with storm-produced features in southern Indiana, U.S.A.. Carbonate petrology seminar, Indiana University

NASA Astrophysics Data System (ADS)

1987-05-01

Most previously described examples of storm-produced stratification have been reported from siliciclastic rocks. However, such features should also be common in carbonate rocks. The Mississippian (Valmeyeran) Ramp Creek and Harrodsburg Limestones, deposited on the east margin of the Illinois Basin on top of the Borden Delta, contain storm-produced features. The dolomitic, geode-bearing Ramp Creek Limestone contains muddying-upward sequences, commonly with scoured bases overlain by grainstones, packstones, wackestones, and burrowed mudstones. These sequences are similar to hummocky sequences formed by storm waves below fair-weather wave base. The middle portion of the section including the upper Ramp Creek and lower Harrodsburg Limestones contains dolomitized mud lenses of uncertain origin. They may have formed by the baffling effect of bryozoans and/or unpreserved algae. The Harrodsburg is gradational with the Ramp Creek and consists predominantly of grainstones and packstones deposited in shallower water. Low-angle cross-stratification and truncation surfaces suggest a foreshore depositional environment for the Harrodsburg. Neither formation contains any indication of supratidal deposition as has been previously suggested. Open marine conditions during deposition of both formations are indicated by the fauna which includes crinoids, bryozoans, brachiopods, corals, ostracods, echinoids, trilobites, molluscs, fish (sharks), and trace fossils.

Optimizing Adiabaticity in a Trapped-Ion Quantum Simulator

NASA Astrophysics Data System (ADS)

Richerme, Phil; Senko, Crystal; Korenblit, Simcha; Smith, Jacob; Lee, Aaron; Monroe, Christopher

2013-05-01

Trapped-ion quantum simulators are a leading platform for the study of interacting spin systems, such as fully-connected Ising models with transverse and axial fields. Phonon-mediated spin-dependent optical dipole forces act globally on a linear chain of trapped Yb-171+ ions to generate the spin-spin couplings, with the form and range of such couplings controlled by laser frequencies and trap voltages. The spins are initially prepared along an effective transverse magnetic field, which is large compared to the Ising couplings and slowly ramped down during the quantum simulation. The system remains in the ground state throughout the evolution if the ramp is adiabatic, and the spin ordering is directly measured by state-dependent fluorescence imaging of the ions onto a camera. Two techniques can improve the identification of the ground state at the end of simulations that are unavoidably diabatic. First, we show an optimized ramp protocol that gives a maximal probability of measuring the true ground state given a finite ramp time. Second, we show that no spin ordering is more prevalent than the ground state(s), even for non-adiabatic ramps. This work is supported by grants from the U.S. Army Research Office with funding from the DARPA OLE program, IARPA, and the MURI program; and the NSF Physics Frontier Center at JQI.

Hartmann-Hahn 2D-map to optimize the RAMP-CPMAS NMR experiment for pharmaceutical materials.

PubMed

Suzuki, Kazuko; Martineau, Charlotte; Fink, Gerhard; Steuernagel, Stefan; Taulelle, Francis

2012-02-01

Cross polarization-magic angle spinning (CPMAS) is the most used experiment for solid-state NMR measurements in the pharmaceutical industry, with the well-known variant RAMP-CPMAS its dominant implementation. The experimental work presented in this contribution focuses on the entangled effects of the main parameters of such an experiment. The shape of the RAMP-CP pulse has been considered as well as the contact time duration, and a particular attention also has been devoted to the radio-frequency (RF) field inhomogeneity. (13)C CPMAS NMR spectra have been recorded with a systematic variation of (13)C and (1)H constant radiofrequency field pair values and represented as a Hartmann-Hahn matching two-dimensional map. Such a map yields a rational overview of the intricate optimal conditions necessary to achieve an efficient CP magnetization transfer. The map also highlights the effects of sweeping the RF by the RAMP-CP pulse on the number of Hartmann-Hahn matches crossed and how RF field inhomogeneity helps in increasing the CP efficiency by using a larger fraction of the sample. In the light of the results, strategies for optimal RAMP-CPMAS measurements are suggested, which lead to a much higher efficiency than constant amplitude CP experiment. Copyright © 2012 John Wiley & Sons, Ltd.

Experimental and Computational Investigation of a Translating-Throat Single-Expansion-Ramp Nozzle

NASA Technical Reports Server (NTRS)

Deere, Karen A.; Asbury, Scott C.

1999-01-01

An experimental and computational study was conducted on a high-speed, single-expansion-ramp nozzle (SERN) concept designed for efficient off-design performance. The translating-throat SERN concept adjusts the axial location of the throat to provide a variable expansion ratio and allow a more optimum jet exhaust expansion at various flight conditions in an effort to maximize nozzle performance. Three design points (throat locations) were investigated to simulate the operation of this concept at subsonic-transonic, low supersonic, and high supersonic flight conditions. The experimental study was conducted in the jet exit test facility at the Langley Research Center. Internal nozzle performance was obtained at nozzle pressure ratios (NPR's) up to 13 for six nozzles with design nozzle pressure ratios near 9, 42, and 102. Two expansion-ramp surfaces, one concave and one convex, were tested for each design point. Paint-oil flow and focusing schlieren flow visualization techniques were utilized to acquire additional flow data at selected NPR'S. The Navier-Stokes code, PAB3D, was used with a two-equation k-e turbulence model for the computational study. Nozzle performance characteristics were predicted at nozzle pressure ratios of 5, 9, and 13 for the concave ramp, low Mach number nozzle and at 10, 13, and 102 for the concave ramp, high Mach number nozzle.

Facies architecture and compositional variations of coves associated with recurrent mass wasting in the Norwegian North Sea.

NASA Astrophysics Data System (ADS)

Olakunle Omosanya, Kamaldeen; Johansen, Ståle

2017-04-01

Coves represent incisions commonly found on the gliding plane of mass-transport deposits (MTDs). Their association with ramps and promontories together causes marked topographic shift at the base of MTDs. Over the past decades, the majority of previous studies have focused on ramps rather than the coves. A debate emanating from these works centre on the origin and mode of formation of ramps. Some authors favour ramps to be tectonic structures while others show that they are erosional features. In this work, we have employed high-resolution 3D seismic reflection dataset and seismic attributes to investigate the evolution, kind and composition of coves found beneath three MTDs. Our attention is not only on the coves but also on the ramps with which they are associated. To do achieve this objective, we have chosen an area characterized by recurrent mass wasting, where one of the biggest submarine landslide in history have been documented. We restored the coves to their depositional geometries by applying techniques of geomorphologic analysis to the tops and bases of the MTDs. Our results revealed the presence of several coves at the base of three major slides i.e., Storegga, Tampen and Slide S. Coves are rugged and scoured sections of the basal shear surface on seismic sections. Their internal architecture includes continuous to slightly deformed reflections, blocky and faulted to strongly deformed packages, and low amplitude chaotic failed mass corresponding to slides, slumps and debris flow deposits. Stratigraphic succession of these seismic facies vary and differ from one coves to another, an indication of the multifaceted flow transformation during mass wasting. Ramps marking the boundaries of the coves are serrated scarps in map view. Our geomorphologic analyses show that blocks within the coves have compacted and are now slumps or deformed reflections on present day seismic data. Slump folds in the coves are kinematic indicators for mass flow direction, which in this study is multidirectional for two of the MTDs. An initial WSW direction of mass flow was succeeded by NW flow during which the coves were filled up to match the topographic position or zenith of the adjacent ramps. We demonstrate that coves, ramps, and slump folds are non-tectonic in origin instead coves are excavation zones or erosional features beneath the MTDs, ramps are their sidewalls, and slump folds are sedimentary imbrications. The coves are formed preferentially on paleo highs where fluid-flow features are prevalent and result from a complex interaction of erosion, sediment loading, and compaction. In the study area, coves are to be found recurring with the three slides and have significant implication for sediment preservation and budget during mass wasting events.

Characterization of Space Shuttle Thermal Protection System (TPS) Materials for Return-to-Flight following the Shuttle Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Wingard, Doug

2006-01-01

During the Space Shuttle Columbia Accident Investigation, it was determined that a large chunk of polyurethane insulating foam (= 1.67 lbs) on the External Tank (ET) came loose during Columbia's ascent on 2-1-03. The foam piece struck some of the protective Reinforced Carbon-Carbon (RCC) panels on the leading edge of Columbia's left wing in the mid-wing area. This impact damaged Columbia to the extent that upon re-entry to Earth, superheGed air approaching 3,000 F caused the vehicle to break up, killing all seven astronauts on board. A paper after the Columbia Accident Investigation highlighted thermal analysis testing performed on External Tank TPS materials (1). These materials included BX-250 (now BX-265) rigid polyurethane foam and SLA-561 Super Lightweight Ablator (highly-filled silicone rubber). The large chunk of foam from Columbia originated fiom the left bipod ramp of the ET. The foam in this ramp area was hand-sprayed over the SLA material and various fittings, allowed to dry, and manually shaved into a ramp shape. In Return-to-Flight (RTF) efforts following Columbia, the decision was made to remove the foam in the bipod ramp areas. During RTF efforts, further thermal analysis testing was performed on BX-265 foam by DSC and DMA. Flat panels of foam about 2-in. thick were sprayed on ET tank material (aluminum alloys). The DSC testing showed that foam material very close to the metal substrate cured more slowly than bulk foam material. All of the foam used on the ET is considered fully cured about 21 days after it is sprayed. The RTF culminated in the successful launch of Space Shuttle Discovery on 7-26-05. Although the flight was a success, there was another serious incident of foam loss fiom the ET during Shuttle ascent. This time, a rather large chunk of BX-265 foam (= 0.9 lbs) came loose from the liquid hydrogen (LH2) PAL ramp, although the foam did not strike the Shuttle Orbiter containing the crew. DMA testing was performed on foam samples taken fiom a simulated PAL ramp panel. It was found that the smooth rind on the foam facing the cable tray did significantly affect the properties of foam at the PAL ramp surface. The smooth rind increased the storage modulus E' of the foam as much as 20- 40% over a temperature range of -145 to 95 C. Because of foam loss fiom the PAL ramp, future Shuttle flights were grounded indefinitely to allow further testing to better understand foam properties. The decision was also made to remove foam from the LH2 PAL, ramp. Other RTF efforts prior to the launch of Discovery included

Measures for preventing wrong-way entries on highways.

DOT National Transportation Integrated Search

1973-01-01

An evaluation of the results of a two-year survey of incidents of wrong-way driving on Virginia highways revealed that the majority of them originated at diamond type interchanges. On-site investigations of a number of the interchanges at which insta...

Implementation and transition of data interchange for geotechnical and geoenvironmental specialists (DIGGS v2.0).

DOT National Transportation Integrated Search

2017-01-01

Data Interchange for Geotechnical and Geoenvironmental Specialists (DIGGS) is an XML-based system : developed under a Federal Highway Administration (FHWA) State Pooled Funding Study led by the : Ohio Department of Transportation (ODOT) from 2005 to ...

77 FR 26604 - Progressive Rail, Incorporated-Lease and Operation Exemption-Rail Line of Union Pacific Railroad...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

... contains an interchange commitment with substantial economic rewards for PGR if it interchanges with UP. One has to wonder why such an economic incentive is necessary if there is little chance that PGR would...

78 FR 62352 - Proposed Agency Information Collection Activities; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-18

... or summary information concerning the costs incurred, and interchange transaction fees charged or... basis) aggregate or summary information concerning the costs incurred, and interchange transaction fees... costs and fixed costs, and to instruct respondents to exclude transactions monitoring from the...

Computer Analysis of Air Pollution from Highways, Streets, and Complex Interchanges

DOT National Transportation Integrated Search

1974-03-01

A detailed computer analysis of air quality for a complex highway interchange was prepared, using an in-house version of the Environmental Protection Agency's Gaussian Highway Line Source Model. This analysis showed that the levels of air pollution n...

Complete intersections : a guide to reconstructing intersections and interchanges for bicyclists and pedestrians.

DOT National Transportation Integrated Search

2010-01-01

Intersections and interchanges are major points of conflict for road users and are the frequent site of injuries and fatalities. In California, nearly 20 percent of pedestrian fatalities, and nearly a quarter of bicyclist fatalities occur at intersec...

Relationship between interchange usage and risk of hamstring injuries in the Australian Football League.

PubMed

Orchard, John W; Driscoll, Tim; Seward, Hugh; Orchard, Jessica J

2012-05-01

To study risk factors for hamstring injury in the Australian Football League (AFL), in particular the effect of recent changes in match participation (increased use of the interchange bench) on hamstring injury. Analysis of hamstring match injury statistics extracted from an injury database combined with match participation statistics extracted from a player statistics database. 56,320 player matches in the AFL over the period 2003-2010 were analyzed, in which 416 hamstring injuries occurred. In a Generalized Estimating Equation (GEE) analysis accounting for clustering of different teams, significant predictors of hamstring injuries were recent hamstring injury (RR 4.16, 95% CI 3.19-5.43), past history of ACL reconstruction (RR 1.69, 95% CI 1.09-2.60), past history of calf injury (RR 1.58, 95% CI 1.37-1.82), opposition team making 60 or more interchanges during the game (RR 1.38, 95% CI 1.12-1.68) and player having made 7 or more interchanges off the field in the last 3 weeks (protective RR 0.74, 95% CI 0.59-0.93). These findings suggest that regular interchanges protect individual players against hamstring injuries, but increase the risk of hamstring injury for opposition players. These findings can be explained by a model in which both fatigue and average match running speed are risk factors for hamstring injury. A player who returns to the ground after a rest on the interchange bench may himself have some short-term protection against hamstring injury because of the reduced fatigue, but his rested state may contribute to increased average running speed for his direct opponent, increasing the risk of injury for players on the opposition team. Copyright © 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Teleoperated Marsupial Mobile Sensor Platform Pair for Telepresence Insertion Into Challenging Structures

NASA Technical Reports Server (NTRS)

Krasowski, Michael J.; Prokop, Norman F.; Greer, Lawrence C.

2011-01-01

A platform has been developed for two or more vehicles with one or more residing within the other (a marsupial pair). This configuration consists of a large, versatile robot that is carrying a smaller, more specialized autonomous operating robot(s) and/or mobile repeaters for extended transmission. The larger vehicle, which is equipped with a ramp and/or a robotic arm, is used to operate over a more challenging topography than the smaller one(s) that may have a more limited inspection area to traverse. The intended use of this concept is to facilitate the insertion of a small video camera and sensor platform into a difficult entry area. In a terrestrial application, this may be a bus or a subway car with narrow aisles or steep stairs. The first field-tested configuration is a tracked vehicle bearing a rigid ramp of fixed length and width. A smaller six-wheeled vehicle approximately 10 in. (25 cm) wide by 12 in. (30 cm) long resides at the end of the ramp within the larger vehicle. The ramp extends from the larger vehicle and is tipped up into the air. Using video feedback from a camera atop the larger robot, the operator at a remote location can steer the larger vehicle to the bus door. Once positioned at the door, the operator can switch video feedback to a camera at the end of the ramp to facilitate the mating of the end of the ramp to the top landing at the upper terminus of the steps. The ramp can be lowered by remote control until its end is in contact with the top landing. At the same time, the end of the ramp bearing the smaller vehicle is raised to minimize the angle of the slope the smaller vehicle has to climb, and further gives the operator a better view of the entry to the bus from the smaller vehicle. Control is passed over to the smaller vehicle and, using video feedback from the camera, it is driven up the ramp, turned oblique into the bus, and then sent down the aisle for surveillance. The demonstrated vehicle was used to scale the steps leading to the interior of a bus whose landing is 44 in. (.1.1 m) from the road surface. This vehicle can position the end of its ramp to a surface over 50 in. (.1.3 m) above ground level and can drive over rail heights exceeding 6 in. (.15 cm). Thus configured, this vehicle can conceivably deliver the smaller robot to the end platform of New York City subway cars from between the rails. This innovation is scalable to other formulations for size, mobility, and surveillance functions. Conceivably the larger vehicle can be configured to traverse unstable rubble and debris to transport a smaller search and rescue vehicle as close as possible to the scene of a disaster such as a collapsed building. The smaller vehicle, tethered or otherwise, and capable of penetrating and traversing within the confined spaces in the collapsed structure, can transport imaging and other sensors to look for victims or other targets.

Is It Necessary to Repair Stable Ramp Lesions of the Medial Meniscus During Anterior Cruciate Ligament Reconstruction? A Prospective Randomized Controlled Trial.

PubMed

Liu, Xin; Zhang, Hui; Feng, Hua; Hong, Lei; Wang, Xue-Song; Song, Guan-Yang

2017-04-01

A special type of meniscal lesion involving the peripheral attachment of the posterior horn of the medial meniscus (PHMM), termed a "ramp lesion," is commonly associated with an anterior cruciate ligament (ACL) injury. However, its treatment is still controversial. Recently, stable ramp lesions treated with abrasion and trephination alone have been shown to have good clinical outcomes after ACL reconstruction. Stable ramp lesions treated with abrasion and trephination alone during ACL reconstruction will result in similar clinical outcomes compared with those treated with surgical repair. Randomized controlled trial; Level of evidence, 2. A prospective randomized controlled study was performed in 91 consecutive patients who had complete ACL injuries and concomitant stable ramp lesions of the medial meniscus. All patients were randomly allocated to 1 of 2 groups based on whether the stable ramp lesions were surgically repaired (study group; n = 50) or only abraded and trephined (control group; n = 41) during ACL reconstruction. All surgical procedures were performed by a single surgeon who was blinded to the functional assessment findings of the patients. The Lysholm score, subjective International Knee Documentation Committee (IKDC) score, and stability assessments (pivot-shift test, Lachman test, KT-1000 arthrometer side-to-side difference, and KT-1000 arthrometer differences of <3, 3-5, and >5 mm) were evaluated preoperatively and at the last follow-up. Moreover, magnetic resonance imaging (MRI) was used to evaluate the healing status of the ramp lesions. All consecutive patients who were screened for eligibility from August 2008 to April 2012 were enrolled and observed clinically. There were 40 patients in the study group and 33 patients in the control group who were observed for at least 2 years. At the final follow-up, there were no significant differences between the study group and the control group in terms of the mean Lysholm score (88.7 ± 4.8 vs 90.4 ± 5.8, respectively; P = .528), mean subjective IKDC score (83.6 ± 3.7 vs 82.2 ± 4.5, respectively; P = .594), pivot-shift test results ( P = .658), Lachman test results ( P = .525), KT-1000 arthrometer side-to-side difference (1.6 ± 1.2 vs 1.5 ± 1.1, respectively; P = .853), or KT-1000 arthrometer grading ( P = .738). Overall, for both groups (n = 73), 67 patients showed completely healed (38 study, 29 control), 3 showed partially healed (1 study, 2 control), and 3 showed nonhealed (1 study, 2 control) signals on follow-up MRI when evaluating the healing status of the ramp lesions. There was no significant difference regarding the healing status of the ramp lesions between the 2 groups ( P = .543). This prospective randomized controlled trial showed that, in terms of subjective scores, knee stability, and meniscal healing status, concomitant stable ramp lesions of the medial meniscus treated with abrasion and trephination alone during ACL reconstruction resulted in similar clinical outcomes compared with those treated with surgical repair.

Using archived data to measure operational benefits of ITS investments, volume 1 : ramp meters.

DOT National Transportation Integrated Search

2004-06-01

develop two case study evaluations for Oregon, including an evaluation of the COMET incident management program and the : Portland ramp metering system. The COMET evaluation will include a thorough literature review of other incident management : pro...

40 CFR 1045.505 - How do I test engines using discrete-mode or ramped-modal duty cycles?

Code of Federal Regulations, 2011 CFR

2011-07-01

... your own testing. If you submit certification test data collected with both discrete-mode and ramped...-use operation. (d) For full-load operating modes, operate the engine at wide-open throttle. (e) See 40...

20. INTERIOR VIEW TO THE EAST OF THE ACCESS RAMP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. INTERIOR VIEW TO THE EAST OF THE ACCESS RAMP TO THE HOT DISASSEMBLY AREA FROM THE COLD ASSEMBLY AREA. - Nevada Test Site, Reactor Maintenance Assembly & Dissassembly Facility, Area 25, Jackass Flats, Junction of Roads F & G, Mercury, Nye County, NV

10. REINFORCED CONCRETE SLAB ROOF FROM SOUTHEASTERN EDGE, ACCESS RAMPS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. REINFORCED CONCRETE SLAB ROOF FROM SOUTHEASTERN EDGE, ACCESS RAMPS AT LEFT AND RIGHT, VIEW TOWARDS NORTHWEST. - Glenn L. Martin Company, Titan Missile Test Facilities, Captive Test Stand D-1, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

78 FR 12322 - Agency Information Collection Activities: OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... Interchange (EDI) Registration and Electronic Data Interchange (EDI) Enrollment Form; Use: The purpose of this... identification of Medicare providers/suppliers and authorization of requested Electronic Data Interface (EDI) functions. The EDI Enrollment and the Medicare Registration Forms are completed by Medicare providers...

FDA Guidance on Biosimilar Interchangeability Elicits Diverse Views: Current and Potential Marketers Complain About Too-High Hurdles.

PubMed

Barlas, Stephen

2017-08-01

Pharmaceutical industry sectors are at odds as the Food and Drug Administration seeks to define "interchangeability" for biosimilars. The battle lines vary by topic, but biosimilar marketers, health plans, and drugstores are generally urging lower hurdles.

19 CFR 122.50 - General order merchandise.

Code of Federal Regulations, 2010 CFR

2010-04-01

... appropriate Customs-authorized electronic data interchange system. Failure to provide such notification may...-authorized electronic data interchange system. If the party fails to notify Customs of the unentered... merchandise or baggage to a bonded warehouse certified by the port director as qualified to receive general...

19 CFR 4.37 - General order.

Code of Federal Regulations, 2011 CFR

2011-04-01

... writing or by any appropriate Customs-authorized electronic data interchange system. Failure to provide... appropriate Customs-authorized electronic data interchange system. If the party fails to notify Customs of the... and unentered merchandise or baggage to a bonded warehouse certified by the port director as qualified...

19 CFR 122.50 - General order merchandise.

Code of Federal Regulations, 2011 CFR

2011-04-01

... appropriate Customs-authorized electronic data interchange system. Failure to provide such notification may...-authorized electronic data interchange system. If the party fails to notify Customs of the unentered... merchandise or baggage to a bonded warehouse certified by the port director as qualified to receive general...

19 CFR 4.37 - General order.

Code of Federal Regulations, 2010 CFR

2010-04-01

... writing or by any appropriate Customs-authorized electronic data interchange system. Failure to provide... appropriate Customs-authorized electronic data interchange system. If the party fails to notify Customs of the... and unentered merchandise or baggage to a bonded warehouse certified by the port director as qualified...

19 CFR 123.10 - General order merchandise.

Code of Federal Regulations, 2011 CFR

2011-04-01

... shall be provided in writing or by any appropriate Customs-authorized electronic data interchange system... any appropriate Customs-authorized electronic data interchange system. If the party fails to notify... unreleased and unentered merchandise or baggage to a bonded warehouse certified by the port director as...

19 CFR 123.10 - General order merchandise.

Code of Federal Regulations, 2010 CFR

2010-04-01

... shall be provided in writing or by any appropriate Customs-authorized electronic data interchange system... any appropriate Customs-authorized electronic data interchange system. If the party fails to notify... unreleased and unentered merchandise or baggage to a bonded warehouse certified by the port director as...

Interchanging lexical information for a multilingual dictionary.

PubMed

Baud, R H; Nyström, M; Borin, L; Evans, R; Schulz, S; Zweigenbaum, P

2005-01-01

To facilitate the interchange of lexical information for multiple languages in the medical domain. To pave the way for the emergence of a generally available truly multilingual electronic dictionary in the medical domain. An interchange format has to be neutral relative to the target languages. It has to be consistent with current needs of lexicon authors, present and future. An active interaction between six potential authors aimed to determine a common denominator striking the right balance between richness of content and ease of use for lexicon providers. A simple list of relevant attributes has been established and published. The format has the potential for collecting relevant parts of a future multilingual dictionary. An XML version is available. This effort makes feasible the exchange of lexical information between research groups. Interchange files are made available in a public repository. This procedure opens the door to a true multilingual dictionary, in the awareness that the exchange of lexical information is (only) a necessary first step, before structuring the corresponding entries in different languages.

76 FR 43477 - Debit Card Interchange Fees and Routing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

...The Board is adopting an interim final rule and requesting comment on provisions in Regulation II (Debit Card Interchange Fees and Routing) adopted in accordance with Section 920(a)(5) of the Electronic Fund Transfer Act, which governs adjustments to debit interchange transaction fees for fraud-prevention costs. The provisions allow an issuer to receive an adjustment of 1 cent to its interchange transaction fee if the issuer develops, implements, and updates policies and procedures reasonably designed to identify and prevent fraudulent electronic debit transactions; monitor the incidence of, reimbursements received for, and losses incurred from fraudulent electronic debit transactions; respond appropriately to suspicious electronic debit transactions so as to limit the fraud losses that may occur and prevent the occurrence of future fraudulent electronic debit transactions; and secure debit card and cardholder data. If an issuer meets these standards and wishes to receive the adjustment, it must certify its eligibility to receive the fraud-prevention adjustment to the payment card networks in which the issuer participates.

Estimation of the Unsteady Aerodynamic Load on Space Shuttle External Tank Protuberances from a Component Wind Tunnel Test

NASA Technical Reports Server (NTRS)

Panda, Jayatana; Martin, Fred W.; Sutliff, Daniel L.

2008-01-01

At the wake of the Columbia (STS-107) accident it was decided to remove the Protuberance Aerodynamic Load (PAL) Ramp that was originally intended to protect various protuberances outside of the Space Shuttle External Tank from high buffet load induced by cross-flows at transonic speed. In order to establish the buffet load without the PAL ramp, a wind tunnel test was conducted where segments of the protuberances were instrumented with dynamic pressure transducers; and power-spectra of sectional lift and drag forces at various span-wise locations between two adjacent support brackets were measured under different cross flow angles, Mach number and other conditions. Additionally, frequency-dependent spatial correlations between the sectional forces were also established. The sectional forces were then adjusted by the correlation length to establish span-averaged spectra of normal and lateral forces that can be suitably "added" to various other unsteady forces encountered by the protuberance. This paper describes the methodology used for calculating the correlation-adjusted power spectrum of the buffet load. A second part of the paper describes wind-tunnel results on the difference in the buffet load on the protuberances with and without the PAL ramp. In general when the ramp height is the same as that of the protuberance height, such as that found on the liquid Oxygen part of the tank, the ramp is found to cause significant reduction of the unsteady aerodynamic load. However, on the liquid Hydrogen part of the tank, where the Oxygen feed-line is far larger in diameter than the height of the PAL ramp, little protection is found to be available to all but the Cable Tray.

Decay of the supersonic turbulent wakes from micro-ramps

NASA Astrophysics Data System (ADS)

Sun, Z.; Schrijer, F. F. J.; Scarano, F.; van Oudheusden, B. W.

2014-02-01

The wakes resulting from micro-ramps immersed in a supersonic turbulent boundary layer at Ma = 2.0 are investigated by means of particle image velocimetry. Two micro-ramps are investigated with height of 60% and 80% of the undisturbed boundary layer, respectively. The measurement domain is placed at the symmetry plane of the ramp and encompasses the range from 10 to 32 ramp heights downstream of the ramp. The decay of the flow field properties is evaluated in terms of time-averaged and root-mean-square (RMS) statistics. In the time-averaged flow field, the recovery from the imparted momentum deficit and the decay of upwash motion are analyzed. The RMS fluctuations of the velocity components exhibit strong anisotropy at the most upstream location and develop into a more isotropic regime downstream. The self-similarity properties of velocity components and fluctuation components along wall-normal direction are followed. The investigation of the unsteady large scale motion is carried out by means of snapshot analysis and by a statistical approach based on the spatial auto-correlation function. The Kelvin-Helmholtz (K-H) instability at the upper shear layer is observed to develop further with the onset of vortex pairing. The average distance between vortices is statistically estimated using the spatial auto-correlation. A marked transition with the wavelength increase is observed across the pairing regime. The K-H instability, initially observed only at the upper shear layer also begins to appear in the lower shear layer as soon as the wake is elevated sufficiently off the wall. The auto-correlation statistics confirm the coherence of counter-rotating vortices from the upper and lower sides, indicating the formation of vortex rings downstream of the pairing region.

The effects of taurine on repeat sprint cycling after low or high cadence exhaustive exercise in females.

PubMed

Waldron, Mark; Knight, Francesca; Tallent, Jamie; Patterson, Stephen; Jeffries, Owen

2018-06-01

This study investigated the effects of taurine on repeated sprint exercise, performed after fixed incremental ramp exercise to exhaustion at isokinetic high (90 r/min) or low (50 r/min) cadences. In a double-blind, repeated measures design, nine females completed an incremental ramp test to volitional exhaustion, followed by 2 min active recovery and 6 × 10 s sprints on a cycle ergometer, in one of four conditions: high cadence (90 r/min) + taurine (50 mg/kg body mass); high cadence + placebo (3 mg/kg body mass maltodextrin); low cadence (50 r/min) + taurine; low cadence + placebo. Heart rate (HR) and blood lactate concentration B[La] were measured before and after the ramp test and after the sprints. Taurine lowered HR vs. placebo prior to the ramp test (P = 0.004; d = 2.1). There was an effect of condition on ramp performance (P < 0.001), with higher end-test power (d = 3.7) in taurine conditions. During repeated sprints, there was a condition × time interaction (P = 0.002), with higher peak sprint power in the placebo conditions compared to taurine (sprint 2-6; P < 0.05). B[La] was higher in taurine compared to placebo post-ramp (P = 0.004; d = 4.7). Taurine-lowered pre-exercise HR and improved incremental end-test power output, with subsequent detrimental effects on sprint performance, independent of cadence. Short endurance performance can be acutely enhanced after taurine ingestion but this effect might not be maintained across longer periods of exercise or induce the need for longer recovery periods.

Ascending-ramp biphasic waveform has a lower defibrillation threshold and releases less troponin I than a truncated exponential biphasic waveform.

PubMed

Huang, Jian; Walcott, Gregory P; Ruse, Richard B; Bohanan, Scott J; Killingsworth, Cheryl R; Ideker, Raymond E

2012-09-11

We tested the hypothesis that the shape of the shock waveform affects not only the defibrillation threshold but also the amount of cardiac damage. Defibrillation thresholds were determined for 11 waveforms-3 ascending-ramp waveforms, 3 descending-ramp waveforms, 3 rectilinear first-phase biphasic waveforms, a Gurvich waveform, and a truncated exponential biphasic waveform-in 6 pigs with electrodes in the right ventricular apex and superior vena cava. The ascending, descending, and rectilinear waveforms had 4-, 8-, and 16-millisecond first phases and a 3.5-millisecond rectilinear second phase that was half the voltage of the first phase. The exponential biphasic waveform had a 60% first-phase and a 50% second-phase tilt. In a second study, we attempted to defibrillate after 10 seconds of ventricular fibrillation with a single ≈30-J shock (6 pigs successfully defibrillated with 8-millisecond ascending, 8-millisecond rectilinear, and truncated exponential biphasic waveforms). Troponin I blood levels were determined before and 2 to 10 hours after the shock. The lowest-energy defibrillation threshold was for the 8-milliseconds ascending ramp (14.6±7.3 J [mean±SD]), which was significantly less than for the truncated exponential (19.6±6.3 J). Six hours after shock, troponin I was significantly less for the ascending-ramp waveform (0.80±0.54 ng/mL) than for the truncated exponential (1.92±0.47 ng/mL) or the rectilinear waveform (1.17±0.45 ng/mL). The ascending ramp has a significantly lower defibrillation threshold and at ≈30 J causes 58% less troponin I release than the truncated exponential biphasic shock. Therefore, the shock waveform affects both the defibrillation threshold and the amount of cardiac damage.

Gait termination on a declined surface in trans-femoral amputees: Impact of using microprocessor-controlled limb system.

PubMed

Abdulhasan, Zahraa M; Scally, Andy J; Buckley, John G

2018-05-30

Walking down ramps is a demanding task for transfemoral-amputees and terminating gait on ramps is even more challenging because of the requirement to maintain a stable limb so that it can do the necessary negative mechanical work on the centre-of-mass in order to arrest (dissipate) forward/downward velocity. We determined how the use of a microprocessor-controlled limb system (simultaneous control over hydraulic resistances at ankle and knee) affected the negative mechanical work done by each limb when transfemoral-amputees terminated gait during ramp descent. Eight transfemoral-amputees completed planned gait terminations (stopping on prosthesis) on a 5-degree ramp from slow and customary walking speeds, with the limb's microprocessor active or inactive. When active the limb operated in its 'ramp-descent' mode and when inactive the knee and ankle devices functioned at constant default levels. Negative limb work, determined as the integral of the negative mechanical (external) limb power during the braking phase, was compared across speeds and microprocessor conditions. Negative work done by each limb increased with speed (p < 0.001), and on the prosthetic limb it was greater when the microprocessor was active compared to inactive (p = 0.004). There was no change in work done across microprocessor conditions on the intact limb (p = 0.35). Greater involvement of the prosthetic limb when the limb system was active indicates its ramp-descent mode effectively altered the hydraulic resistances at the ankle and knee. Findings highlight participants became more assured using their prosthetic limb to arrest centre-of-mass velocity. Copyright © 2018 Elsevier Ltd. All rights reserved.

Sand ramps as palaeoenvironmental archives: Integrating general principles and regional contexts through reanalysis of the Klipkraal Sands, South Africa

NASA Astrophysics Data System (ADS)

Rowell, Alexandra L. K.; Thomas, David S. G.; Bailey, Richard M.; Holmes, Peter J.

2018-06-01

Sand ramps occur on a continuum of topographically-controlled landforms, ranging from purely aeolian features (climbing/falling dunes) to talus cones and alluvial fans. Sand ramps have been identified as potentially important palaeoenvironmental archives in dryland regions that possess relatively few Quaternary proxy records. Their utility however requires not only good age control of depositional phases but clear identification of process regimes, determined through morphological and sedimentological analyses, with several recent studies indicating the complexities of palaeoenvironmental interpretations and the controls of ramp development (Bateman et al., 2012; Rowell et al., 2018). Klipkraal Sands is a sand ramp on the north-eastern margin of the semi-arid Karoo that has been important for inferences of the extent of southern African Late Quaternary aeolian activity (Thomas et al., 2002). We reanalyse this feature, in the light of both its significance and other recent studies that have inferred extensive southern African LGM aeolian activity (Telfer et al., 2012, 2014). New sedimentological data and twelve OSL dates indicate the Klipkraal Sands formed episodically between 100-0.14 ka, rather than accumulating rapidly, while sedimentological data question the aeolian affinities of the bulk of the feature. Therefore, Klipkraal is reinterpreted as showing no particular affinity to the LGM, with sediments locally sourced with a significant colluvial component. Only the upper historical sediments can be clearly interpreted as aeolian deposits. A complex interplay of processes is suggested, for which a meaningful palaeoenvironmental interpretation cannot be easily defined. This implies that the local geomorphic processes and controls operating on sand ramps need to be established before they can be fully utilised as palaeoenvironmental archives, with implications for their interpretation worldwide.

Analogue modelling of thrust systems: Passive vs. active hanging wall strain accommodation and sharp vs. smooth fault-ramp geometries

NASA Astrophysics Data System (ADS)

Rosas, F. M.; Duarte, J. C.; Almeida, P.; Schellart, W. P.; Riel, N.; Terrinha, P.

2017-06-01

We present new analogue modelling results of crustal thrust-systems in which a deformable (brittle) hanging wall is assumed to endure passive internal deformation during thrusting, i.e. exclusively as a consequence of having to adapt its shape to the variable geometry of a rigid footwall. Building on previous experimental contributions, we specifically investigate the role of two so far overlooked critical variables: a) concave-convex (CC) vs. flat-ramp-flat (FRF) thrust ramp geometry; and b) presence vs. absence of a basal velocity discontinuity (VD). Regarding the first variable, we compare new results for considered (CC) smoother ramp types against classical experiments in which (FRF) sharp ramp geometries are always prescribed. Our results show that the considered sharp vs. smooth variation in the thrust-ramp geometry produces important differences in the distribution of the local stress field in the deformable hanging wall above both (lower and upper) fault bends, with corresponding styles of strain accommodation being expressed by marked differences in measured morpho-structural parameters. Regarding the second variable, we for the first time report analogue modelling results of this type of experiments in which basal VDs are experimentally prescribed to be absent. Our results critically show that true passive hanging wall deformation is only possible to simulate in the absence of any basal VD, since active shortening accommodation always necessarily occurs in the hanging wall above such a discontinuity (i.e. above the lower fault bend). In addition, we show that the morpho-structural configuration of model thrust-wedges formed for prescribed VD absence conditions complies well with natural examples of major overthrusts, wherein conditions must occur that approximate a frictionless state along the main basal thrust-plane.

Efficient decentralized consensus protocols

NASA Technical Reports Server (NTRS)

Lakshman, T. V.; Agrawala, A. K.

1986-01-01

Decentralized consensus protocols are characterized by successive rounds of message interchanges. Protocols which achieve a consensus in one round of message interchange require O(N-squared) messages, where N is the number of participants. In this paper, a communication scheme, based on finite projective planes, which requires only O(N sq rt N) messages for each round is presented. Using this communication scheme, decentralized consensus protocols which achieve a consensus within two rounds of message interchange are developed. The protocols are symmetric, and the communication scheme does not impose any hierarchical structure. The scheme is illustrated using blocking and nonblocking commit protocols, decentralized extrema finding, and computation of the sum function.

Members of the S&T Partnership Forum Meet for an In-Space Assembly Technical Interchange Meeting on September 6th, 2017

NASA Image and Video Library

2017-09-06

WASHINGTON, D.C.---S&T Partnership Forum In-Space Assembly Technical Interchange Meeting-On September 6th 2017, many of the United States government experts on In-Space Assembly met at the U.S. Naval Research Lab to discuss both technology development and in-space applications that would advance national capabilities in this area. Expertise from NASA, USAF, NRO, DARPA and NRL met in this meeting which was coordinated by the NASA Headquarters, Office of the Chief Technologist. This technical interchange meeting was the second meeting of the members of this Science and Technology Partnership Forum.

10 CFR 63.133 - Design testing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... design, such as, for example, borehole and shaft seals, backfill, and drip shields, as well as the... placement is begun. (d) Tests must be conducted to evaluate the effectiveness of borehole, shaft, and ramp seals before full-scale operation proceeds to seal boreholes, shafts, and ramps. ...

14 CFR 382.95 - What are carriers' general obligations with respect to boarding and deplaning assistance?

Code of Federal Regulations, 2010 CFR

2010-01-01

... wheelchairs where provided in accordance with this Part, and ramps or mechanical lifts. (b) As a carrier, you... the use of lifts or ramps at any U.S. commercial service airport with 10,000 or more annual...

14 CFR 382.95 - What are carriers' general obligations with respect to boarding and deplaning assistance?

Code of Federal Regulations, 2011 CFR

2011-01-01

... wheelchairs where provided in accordance with this Part, and ramps or mechanical lifts. (b) As a carrier, you... the use of lifts or ramps at any U.S. commercial service airport with 10,000 or more annual...

Static internal performance of single expansion-ramp nozzles with thrust vectoring and reversing

NASA Technical Reports Server (NTRS)

Re, R. J.; Berrier, B. L.

1982-01-01

The effects of geometric design parameters on the internal performance of nonaxisymmetric single expansion-ramp nozzles were investigated at nozzle pressure ratios up to approximately 10. Forward-flight (cruise), vectored-thrust, and reversed-thrust nozzle operating modes were investigated.

Truck accidents at freeway ramps : data analysis and high-risk site identification

DOT National Transportation Integrated Search

1998-01-01

To examine the relationship of ramp design to truck accident rates, this paper presents an analysis of truck accidents in Washington State, plus a comparison to limited data from Colorado and California. The authors group freeway truck accidents by r...

77 FR 60302 - Special Local Regulations; Red Bull Flugtag Miami, Biscayne Bay; Miami, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... of 30 participants launching self-propelled flying machines from a 30ft ramp to the water below. 150... machines from a 30ft ramp to the water below. 150 spectator vessels are expected to attend the event. The...

Measuring effectiveness of ramp metering strategies on I-12.

DOT National Transportation Integrated Search

2011-05-01

The main goal of this research is to conduct an overall assessment of the effectiveness of the newly implemented ramp metering strategy on I-12 in the Baton Rouge area. The research objectives of this study are to: 1. Conduct a brief literature revie...

Orion Service Module Reaction Control System Plume Impingement Analysis Using PLIMP/RAMP2

NASA Technical Reports Server (NTRS)

Wang, Xiao-Yen J.; Gati, Frank; Yuko, James R.; Motil, Brian J.; Lumpkin, Forrest E.

2009-01-01

The Orion Crew Exploration Vehicle Service Module Reaction Control System engine plume impingement was computed using the plume impingement program (PLIMP). PLIMP uses the plume solution from RAMP2, which is the refined version of the reacting and multiphase program (RAMP) code. The heating rate and pressure (force and moment) on surfaces or components of the Service Module were computed. The RAMP2 solution of the flow field inside the engine and the plume was compared with those computed using GASP, a computational fluid dynamics code, showing reasonable agreement. The computed heating rate and pressure using PLIMP were compared with the Reaction Control System plume model (RPM) solution and the plume impingement dynamics (PIDYN) solution. RPM uses the GASP-based plume solution, whereas PIDYN uses the SCARF plume solution. Three sets of the heating rate and pressure solutions agree well. Further thermal analysis on the avionic ring of the Service Module showed that thermal protection is necessary because of significant heating from the plume.

Impacts of Wind and Solar on Fossil-Fueled Generators: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lew, D.; Brinkman, G.; Kumar, N.

2012-08-01

High penetrations of wind and solar power will impact the operations of the remaining generators on the power system. Regional integration studies have shown that wind and solar may cause fossil-fueled generators to cycle on and off and ramp down to part load more frequently and potentially more rapidly. Increased cycling, deeper load following, and rapid ramping may result in wear-and-tear impacts on fossil-fueled generators that lead to increased capital and maintenance costs, increased equivalent forced outage rates, and degraded performance over time. Heat rates and emissions from fossil-fueled generators may be higher during cycling and ramping than during steady-statemore » operation. Many wind and solar integration studies have not taken these increased cost and emissions impacts into account because data have not been available. This analysis considers the cost and emissions impacts of cycling and ramping of fossil-fueled generation to refine assessments of wind and solar impacts on the power system.« less

The Future Impact of Wind on BPA Power System Ancillary Services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarov, Yuri V.; Lu, Shuai; McManus, Bart

Wind power is growing in a very fast pace as an alternative generating resource. As the ratio of wind power over total system capacity increases, the impact of wind on various system aspects becomes significant. This paper presents a methodology to study the future impact of wind on BPA power system ancillary services including load following and regulation. Existing approaches for similar analysis include dispatch model simulation and standard deviation evaluation. The methodology proposed in this paper uses historical data and stochastic processes to simulate the load balancing processes in BPA power system. Then capacity, ramp rate and ramp durationmore » characteristics are extracted from the simulation results, and load following and regulation requirements are calculated accordingly. It mimics the actual power system operations therefore the results can be more realistic yet the approach is convenient to perform. Further, the ramp rate and ramp duration data obtained from the analysis can be used to evaluate generator response or maneuverability and energy requirement, respectively, additional to the capacity requirement.« less

Response of humpback whales (Megaptera novaeangliae) to ramp-up of a small experimental air gun array.

PubMed

Dunlop, Rebecca A; Noad, Michael J; McCauley, Robert D; Kniest, Eric; Slade, Robert; Paton, David; Cato, Douglas H

2016-02-15

'Ramp-up', or 'soft start', is a mitigation measure used in seismic surveys and involves increasing the radiated sound level over 20-40 min. This study compared the behavioural response in migrating humpback whales to the first stages of ramp-up with the response to a 'constant' source, 'controls' (in which the array was towed but not operated) with groups in the absence of the source vessel used as the 'baseline'. Although the behavioural response, in most groups, resulted in an increase in distance from the source (potential avoidance), there was no evidence that either 'ramp-up' or the constant source at a higher level was superior for triggering whales to move away from the source vessel. 'Control' groups also responded suggesting the presence of the source vessel had some effect. However, the majority of groups appeared to avoid the source vessel at distances greater than the radius of most mitigation zones. Copyright © 2016 Elsevier Ltd. All rights reserved.

Folding of a detachment and fault - Modified detachment folding along a lateral ramp, southwestern Montana, USA

NASA Astrophysics Data System (ADS)

Schmidt, Christopher; Whisner, S. Christopher; Whisner, Jennifer B.

2014-12-01

The inversion of the Middle Proterozoic Belt sedimentary basin during Late Cretaceous thrusting in Montana produced a large eastwardly-convex salient, the southern boundary of which is a 200 km-long oblique to lateral ramp subtended by a detachment between the Belt rocks and Archean basement. A 10 km-long lateral ramp segment exposes the upper levels of the detachment where hanging wall Belt rocks have moved out over the Paleozoic and Mesozoic section. The hanging wall structure consists of a train of high amplitude, faulted, asymmetrical detachment folds. Initial west-east shortening produced layer parallel shortening fabrics and dominantly strike slip faulting followed by symmetrical detachment folding. 'Lock-up' of movement on the detachment surface produced regional simple shear and caused the detachment folds to become asymmetrical and faulted. Folding of the detachment surface after lock-up modified the easternmost detachment folds further into a southeast-verging, overturned fold pair with a ramp-related fault along the base of the stretched mutual limb.

Learning Across Cultures: Intercultural Communication and International Educational Exchange.

ERIC Educational Resources Information Center

Althen, Gary, Ed.; And Others

Aspects of intercultural educational activity, research on learning, and implications for educational interchange, and case studies of the application of ideas from the intercultural communication field to work in international educational interchange are addressed in nine papers. Contents include: "Dynamics of Cross-cultural Adjustment: from…

Electronic Data Interchange: Using Technology to Exchange Transcripts.

ERIC Educational Resources Information Center

Stewart, John T.

1994-01-01

Describes the Florida Automated System for Transferring Educational Records (FASTER) project, which permits the electronic exchange of student transcripts; uses of similar electronic data interchange (EDI) programs in other states; and the national SPEEDE/ExPRESS project, which uses a standard format for transferring electronic transcripts.…

Electronic Data Interchange (EDI) for Libraries and Publishers.

ERIC Educational Resources Information Center

Santosuosso, Joe

1992-01-01

Defines electronic data interchange (EDI) as the exchange of data between computer systems without human intervention or interpretation. Standards are discussed; and the implementation of EDI in libraries and the serials publishing community in the areas of orders and acquisitions, claims, and invoice processing is described. (LRW)

Electronic Data Interchange: Selected Issues and Trends.

ERIC Educational Resources Information Center

Wigand, Rolf T.; And Others

1993-01-01

Describes electronic data interchange (EDI) as the application-to-application exchange of business documents in a computer-readable format. Topics discussed include EDI in various industries, EDI in finance and banking, organizational impacts of EDI, future EDI markets and organizations, and implications for information resources management.…

Costs and benefits of strategic acquisition of limited access right-of-way at freeway interchange areas

DOT National Transportation Integrated Search

2004-11-01

The purpose of this research is to assess the cost effectiveness of purchasing additional limited access right-of-way at the time of construction in lieu of retrofitting interchange areas after functional failure. The findings indicate that the long ...

2014 Trans-Atlantic Research and Development Interchange on Sustainability (Tardis 2014): Summary of Discussions

EPA Science Inventory

The Trans-Atlantic Research and Development Interchange on Sustainability (TARDIS) has been bringing together a select group of scientists and engineers for in-depth discussions on sustainability on a bi-annual basis since 2004. TARDIS 2014 included twenty eight individuals from ...

Focus on Nutrition. MCH Program Interchange.

ERIC Educational Resources Information Center

National Center for Education in Maternal and Child Health, Washington, DC.

This issue of the "MCH Program Interchange" describes selected materials and publications in maternal and child health (MCH) nutrition services and programs. The materials were developed by or are available from federal agencies, state and local public health agencies, and voluntary and professional organizations. The information is intended to…

Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay.

PubMed

Lee-Lewandrowski, Elizabeth; Januzzi, James L; Green, Sandy M; Tannous, Bakhos; Wu, Alan H B; Smith, Andrew; Wong, Alicia; Murakami, MaryAnn M; Kaczmarek, Jason; Apple, Fred S; Miller, Wayne L; Hartman, Karen; Jaffe, Allan S

2007-01-01

NT-proBNP measurements aid in the evaluation of patients with suspected heart failure (HF) and may facilitate risk stratification in patients with HF and acute coronary syndrome (ACS). Point-of-care (POC) assays may provide more timely results and potentially improve patient outcomes. We evaluated the analytical performance of the Response Biomedical Corporation whole blood RAMP amino-terminal pro-B type natriuretic peptide (NT-proBNP) POC assay compared to the Roche Elecsys proBNP (NT-proBNP) assay. Intra-day and total imprecision (% CV) ranged from 5.5% to 10.3% at 140, 449 and 1675 ng/L. The lowest concentration that yields a 20% CV was 57 ng/L. The lower limit of detection was 18 ng/L. The upper limit of linearity was validated to 23,428 ng/L with an average recovery of 95%. Correlation by Passing and Bablok regression yielded RAMP=1.01 Elecsys+14.6, r=0.98 (n=540; range of Elecsys values <5 to >35,000). Concordance of RAMP versus Elecsys using cut-offs of 125 ng/L for subjects <75 years and 450 ng/L for subjects > or =75 was 92% (95% CI 89-94%) for a group consisting of 127 apparently healthy individuals and 208 non-healthy subjects without HF, and 99% (95% CI 97-100%) for patients with HF, using the New York Heart Association (NYHA) functional classification. Overall, 80%, 87%, 97% and 100% of the RAMP results and 77%, 85%, 96% and 100% of the Elecsys results were greater than the age appropriate cut-off for NYHA I, II, III or IV groups. For both the RAMP and Elecsys results, the median NT-proBNP value was statistically correlated (increasing) with NYHA I, II, III or IV groups, respectively (p<0.0001), with no significant difference between the two methods. The POC Response Biomedical RAMP NT-proBNP assay provides comparable results that measured on the FDA cleared Roche Elecsys central laboratory platform.

Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Programme-Diabetes Mellitus (RAMP-DM) on Diabetes-Related Complications and Health Service Uses-A Population-Based and Propensity-Matched Cohort Study.

PubMed

Wan, Eric Yuk Fai; Fung, Colman Siu Cheung; Jiao, Fang Fang; Yu, Esther Yee Tak; Chin, Weng Yee; Fong, Daniel Yee Tak; Wong, Carlos King Ho; Chan, Anca Ka Chun; Chan, Karina Hiu Yen; Kwok, Ruby Lai Ping; Lam, Cindy Lo Kuen

2018-01-01

To evaluate the 5-year effectiveness of a multidisciplinary Risk Assessment and Management Programme-Diabetes Mellitus (RAMP-DM) in primary care patients with type 2 diabetes. A 5-year prospective cohort study was conducted with 121,584 Chinese primary care patients with type 2 DM who were recruited between August 2009 and June 2011. Missing data were dealt with multiple imputations. After excluding patients with prior diabetes mellitus (DM)-related complications and one-to-one propensity score matching on all patient characteristics, 26,718 RAMP-DM participants and 26,718 matched usual care patients were followed up for a median time of 4.5 years. The effect of RAMP-DM on nine DM-related complications and all-cause mortality were evaluated using Cox regressions. The first incidence for each event was used for all models. Health service use was analyzed using negative binomial regressions. Subgroup analyses on different patient characteristics were performed. The cumulative incidence of all events (DM-related complications and all-cause mortality) was 23.2% in the RAMP-DM group and 43.6% in the usual care group. RAMP-DM led to significantly greater reductions in cardiovascular disease (CVD) risk by 56.6% (95% CI 54.5, 58.6), microvascular complications by 11.9% (95% CI 7.0, 16.6), mortality by 66.1% (95% CI 64.3, 67.9), specialist attendance by 35.0% (95% CI 33.6, 36.4), emergency attendance by 41.2% (95% CI 39.8, 42.5), and hospitalizations by 58.5% (95% CI 57.2, 59.7). Patients with low baseline CVD risks benefitted the most from RAMP-DM, which decreased CVD and mortality risk by 60.4% (95% CI 51.8, 67.5) and 83.6% (95% CI 79.3, 87.0), respectively. This naturalistic study highlighted the importance of early optimal DM control and risk factor management by risk stratification and multidisciplinary, protocol-driven, chronic disease model care to delay disease progression and prevent complications. © 2017 by the American Diabetes Association.

Dynamics of Coronal Hole Boundaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Higginson, A. K.; Zurbuchen, T. H.; Antiochos, S. K.

Remote and in situ observations strongly imply that the slow solar wind consists of plasma from the hot, closed-field corona that is released onto open magnetic field lines. The Separatrix Web theory for the slow wind proposes that photospheric motions at the scale of supergranules are responsible for generating dynamics at coronal-hole boundaries, which result in the closed plasma release. We use three-dimensional magnetohydrodynamic simulations to determine the effect of photospheric flows on the open and closed magnetic flux of a model corona with a dipole magnetic field and an isothermal solar wind. A rotational surface motion is used tomore » approximate photospheric supergranular driving and is applied at the boundary between the coronal hole and helmet streamer. The resulting dynamics consist primarily of prolific and efficient interchange reconnection between open and closed flux. The magnetic flux near the coronal-hole boundary experiences multiple interchange events, with some flux interchanging over 50 times in one day. Additionally, we find that the interchange reconnection occurs all along the coronal-hole boundary and even produces a lasting change in magnetic-field connectivity in regions that were not driven by the applied motions. Our results show that these dynamics should be ubiquitous in the Sun and heliosphere. We discuss the implications of our simulations for understanding the observed properties of the slow solar wind, with particular focus on the global-scale consequences of interchange reconnection.« less

Observations of a Small Interplanetary Magnetic Flux Rope Opening by Interchange Reconnection

NASA Astrophysics Data System (ADS)

Wang, J. M.; Feng, H. Q.; Zhao, G. Q.

2018-01-01

Interchange reconnection, specifically magnetic reconnection between open magnetic fields and closed magnetic flux ropes, plays a major role in the heliospheric magnetic flux budget. It is generally accepted that closed magnetic field lines of interplanetary magnetic flux ropes (IMFRs) can gradually open through reconnection between one of its legs and other open field lines until no closed field lines are left to contribute flux to the heliosphere. In this paper, we report an IMFR associated with a magnetic reconnection exhaust, whereby its closed field lines were opening by a magnetic reconnection event near 1 au. The reconnection exhaust and the following IMFR were observed on 2002 February 2 by both the Wind and ACE spacecraft. Observations on counterstreaming suprathermal electrons revealed that most magnetic field lines of the IMFR were closed, especially those after the front boundary of the IMFR, with both ends connected to the Sun. The unidirectional suprathermal electron strahls before the exhaust manifested the magnetic field lines observed before the exhaust was open. These observations provide direct evidence that closed field lines of IMFRs can be opened by interchange reconnection in interplanetary space. This is the first report of the closed field lines of IMFRs being opened by interchange reconnection in interplanetary space. This type of interplanetary interchange reconnection may pose important implications for balancing the heliospheric flux budget.

Effects of Hybrid Flow Control on a Normal Shock Boundary-Layer Interaction

NASA Technical Reports Server (NTRS)

Hirt, Stefanie M.; Vyas, Manan A.

2013-01-01

Hybrid flow control, a combination of micro-ramps and steady micro-jets, was experimentally investigated in the 15x15 cm Supersonic Wind Tunnel at the NASA Glenn Research Center. A central composite design of experiments method, was used to develop response surfaces for boundary-layer thickness and reversed-flow thickness, with factor variables of inter-ramp spacing, ramp height and chord length, and flow injection ratio. Boundary-layer measurements and wall static pressure data were used to understand flow separation characteristics. A limited number of profiles were measured in the corners of the tunnel to aid in understanding the three-dimensional characteristics of the flowfield.

Airbags and Sojourner Rover

NASA Image and Video Library

1997-07-05

This image from the Imager for Mars Pathfinder (IMP) camera shows the rear part of the Sojourner rover, the rolled-up rear ramp, and portions of the partially deflated airbags. The Alpha Proton X-ray Spectrometer instrument is protruding from the rear (right side) of the rover. The airbags behind the rover are presently blocking the ramp from being safely unfurled. The ramps are a pair of deployable metal reels that will provide a track for the rover as it slowly rolls off the lander, and onto the surface of Mars, once Pathfinder scientists determine it is safe to do so. http://photojournal.jpl.nasa.gov/catalog/PIA00614

Unsteady magnetohydrodynamic free convection flow of a second grade fluid in a porous medium with ramped wall temperature.

PubMed

Samiulhaq; Ahmad, Sohail; Vieru, Dumitru; Khan, Ilyas; Shafie, Sharidan

2014-01-01

Magnetic field influence on unsteady free convection flow of a second grade fluid near an infinite vertical flat plate with ramped wall temperature embedded in a porous medium is studied. It has been observed that magnitude of velocity as well as skin friction in case of ramped temperature is quite less than the isothermal temperature. Some special cases namely: (i) second grade fluid in the absence of magnetic field and porous medium and (ii) Newtonian fluid in the presence of magnetic field and porous medium, performing the same motion are obtained. Finally, the influence of various parameters is graphically shown.

Re-forming supercritical quasi-parallel shocks. I - One- and two-dimensional simulations

NASA Technical Reports Server (NTRS)

Thomas, V. A.; Winske, D.; Omidi, N.

1990-01-01

The process of reforming supercritical quasi-parallel shocks is investigated using one-dimensional and two-dimensional hybrid (particle ion, massless fluid electron) simulations both of shocks and of simpler two-stream interactions. It is found that the supercritical quasi-parallel shock is not steady. Instread of a well-defined shock ramp between upstream and downstream states that remains at a fixed position in the flow, the ramp periodically steepens, broadens, and then reforms upstream of its former position. It is concluded that the wave generation process is localized at the shock ramp and that the reformation process proceeds in the absence of upstream perturbations intersecting the shock.

Real-time adaptive ramp metering : phase I, MILOS proof of concept (multi-objective, integrated, large-scale, optimized system).

DOT National Transportation Integrated Search

2006-12-01

Over the last several years, researchers at the University of Arizonas ATLAS Center have developed an adaptive ramp : metering system referred to as MILOS (Multi-Objective, Integrated, Large-Scale, Optimized System). The goal of this project : is ...

Exterior direct detail view of revised entry handicap ramp at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Exterior direct detail view of revised entry handicap ramp at east side of Building 7 (including 3-story trash dump tower), looking north - North Beach Place, 431 Bay Street, 530 Francisco Street, 431 Bay Street, 530 Francisco Street, San Francisco, San Francisco County, CA

North side, middle section, looking west at exterior ramp and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North side, middle section, looking west at exterior ramp and enclosed corridor connecting buildings 511 and 515. East side of corridor. Building 516 is to the right. - Fitzsimons General Hospital, Infirmary, Northwest Corner of East Bushnell Avenue & South Page Street, Aurora, Adams County, CO

Effectiveness of School Counselor Supervision with Trainees Utilizing the ASCA Model

ERIC Educational Resources Information Center

Blakely, Colette; Underwood, Lee A.; Rehfuss, Mark

2009-01-01

This study sought to determine if differences existed in the supervision of school counselors in traditional school counseling programs versus Recognized ASCA Model Programs (RAMP). The findings indicated that there are significant differences between traditional counseling supervisors and RAMP counseling supervisors across all supervisory…

Detail of staircase (stepped ramp) and retaining wall at West ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of staircase (stepped ramp) and retaining wall at West 102nd Street, soccer field at right, looking south, with London Plane trees surrounding field. - Henry Hudson Parkway, Extending 11.2 miles from West 72nd Street to Bronx-Westchester border, New York County, NY