Hard probes of short-range nucleon-nucleon correlations

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Arrington, D. W. Higinbotham, G. Rosner, M. Sargsian

2012-10-01

The strong interaction of nucleons at short distances leads to a high-momentum component to the nuclear wave function, associated with short-range correlations between nucleons. These short-range, high-momentum structures in nuclei are one of the least well understood aspects of nuclear matter, relating to strength outside of the typical mean-field approaches to calculating the structure of nuclei. While it is difficult to study these short-range components, significant progress has been made over the last decade in determining how to cleanly isolate short-range correlations in nuclei. We have moved from asking if such structures exist, to mapping out their strength in nucleimore » and studying their microscopic structure. A combination of several different measurements, made possible by high-luminosity and high-energy accelerators, coupled with an improved understanding of the reaction mechanism issues involved in studying these structures, has led to significant progress, and provided significant new information on the nature of these small, highly-excited structures in nuclei. We review the general issues related to short-range correlations, survey recent experiments aimed at probing these short-range structures, and lay out future possibilities to further these studies.« less

78 FR 16189 - Transportation of Agricultural Commodities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... 32934, respectively, of the Moving Ahead for Progress in the 21st Century Act (MAP-21). Although prior statutory exemptions involving agriculture are unchanged, some of these exemptions overlap with MAP-21... HM Hazardous Materials HOS Hours of Service MAP-21 Moving Ahead for Progress in the 21st Century Act...

The Impact of the Measures of Academic Progress (MAP) Program on Student Reading Achievement

ERIC Educational Resources Information Center

Cordray, David S.; Pion, Georgine M.; Brandt, Chris; Molefe, Ayrin

2013-01-01

One of the most widely used commercially available systems incorporating benchmark assessment and training in differentiated instruction is the Northwest Evaluation Association's (NWEA) Measures of Academic Progress (MAP) program. The MAP program involves two components: (1) computer-adaptive assessments administered to students three to four…

Identification of sero-reactive antigens for the early diagnosis of Johne’s disease in cattle

PubMed Central

Randall, Arlo; Grohn, Yrjo T.; Katani, Robab; Schilling, Megan; Radzio-Basu, Jessica

2017-01-01

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s disease (JD), a chronic intestinal inflammatory disease of cattle and other ruminants. JD has a high herd prevalence and causes serious animal health problems and significant economic loss in domesticated ruminants throughout the world. Since serological detection of MAP infected animals during the early stages of infection remains challenging due to the low sensitivity of extant assays, we screened 180 well-characterized serum samples using a whole proteome microarray from Mycobacterium tuberculosis (MTB), a close relative of MAP. Based on extensive testing of serum and milk samples, fecal culture and qPCR for direct detection of MAP, the samples were previously assigned to one of 4 groups: negative low exposure (n = 30, NL); negative high exposure (n = 30, NH); fecal positive, ELISA negative (n = 60, F+E-); and fecal positive, ELISA positive (n = 60, F+E+). Of the 740 reactive proteins, several antigens were serologically recognized early but not late in infection, suggesting a complex and dynamic evolution of the MAP humoral immune response during disease progression. Ordinal logistic regression models identified a subset of 47 candidate proteins with significantly different normalized intensity values (p<0.05), including 12 in the NH and 23 in F+E- groups, suggesting potential utility for the early detection of MAP infected animals. Next, the diagnostic utility of four MAP orthologs (MAP1569, MAP2942c, MAP2609, and MAP1272c) was assessed and reveal moderate to high diagnostic sensitivities (range 48.3% to 76.7%) and specificity (range 96.7% to 100%), with a combined 88.3% sensitivity and 96.7% specificity. Taken together, the results of our analyses have identified several candidate MAP proteins of potential utility for the early detection of MAP infection, as well individual MAP proteins that may serve as the foundation for the next generation of well-defined serological diagnosis of JD in cattle. PMID:28863177

Evaluating progressive-rendering algorithms in appearance design tasks.

PubMed

Jiawei Ou; Karlik, Ondrej; Křivánek, Jaroslav; Pellacini, Fabio

2013-01-01

Progressive rendering is becoming a popular alternative to precomputational approaches to appearance design. However, progressive algorithms create images exhibiting visual artifacts at early stages. A user study investigated these artifacts' effects on user performance in appearance design tasks. Novice and expert subjects performed lighting and material editing tasks with four algorithms: random path tracing, quasirandom path tracing, progressive photon mapping, and virtual-point-light rendering. Both the novices and experts strongly preferred path tracing to progressive photon mapping and virtual-point-light rendering. None of the participants preferred random path tracing to quasirandom path tracing or vice versa; the same situation held between progressive photon mapping and virtual-point-light rendering. The user workflow didn’t differ significantly with the four algorithms. The Web Extras include a video showing how four progressive-rendering algorithms converged (at http://youtu.be/ck-Gevl1e9s), the source code used, and other supplementary materials.

From biocontrol to cancer, probiotics and beyond

PubMed Central

Dunne, Colum

2013-01-01

This invited commentary covers the period 1997–2012 and has seen changes in terminology that progressed from “basic” and “applied” to “translational” research. In the context of Bioengineered, these changes map readily onto the processes of identifying microbial characteristics appropriate for specific applications, isolation of suitable cultures, strain or genome manipulation and exploitation of these or their metabolomes across a range of settings. PMID:23247300

Outcome mapping for fostering and measuring change in risk management behaviour among urban dairy farmers in Nairobi, Kenya.

PubMed

Nyangaga, Julius N; Grace, Delia; Kimani, Violet; Kiragu, Monica W; Langat, Alfred K; Mbugua, Gabriel; Mitoko, Grace; Kang'ethe, Erastus K

2012-09-01

A study was undertaken to investigate and mitigate the risk from zoonotic Cryptosporidium associated with dairy farming in Dagoretti division, Nairobi, Kenya. Outcome mapping (OM), a relatively new tool for planning and evaluation, was used to foster and then monitor changes in farmer management of health risks. Elements of the OM framework, including the vision, mission and expected progress markers, were developed in participatory sessions and a set of progress markers was used for monitoring behaviour change in farmers participating in the project (the boundary partners). Behaviour change (the outcome challenge) was supported by a range of awareness and educational campaigns, working with strategic partners (extension agents and administrative leaders). The farmers the project worked with made considerable progress according to the markers; they demonstrated an understanding of cryptosporidiosis, established or maintained clean and well drained cattle sheds, and took conscious effort to reduce possible infection. Farmers who did not participate in the project (non-contact farmers) were found to be less advanced on the progress marker indicators. Non-contact farmers who carried out risk-reducing practices had done so independently of the project team. The administration leaders, as strategic partners, had a positive attitude towards the project and confidence in their ability to support project objectives. The study demonstrates the utility of OM in helping to identify and support behavioural change.

A Human-in-the Loop Exploration of the Dynamic Airspace Configuration Concept

NASA Technical Reports Server (NTRS)

Homola, Jeffrey; Lee, Paul U.; Prevot, Thomas; Lee, Hwasoo; Kessell, Angela; Brasil, Connie; Smith, Nancy

2010-01-01

An exploratory human-in-the-loop study was conducted to better understand the impact of Dynamic Airspace Configuration (DAC) on air traffic controllers. To do so, a range of three progressively more aggressive algorithmic approaches to sectorizations were chosen. Sectorizations from these algorithms were used to test and quantify the range of impact on the controller and traffic. Results show that traffic count was more equitably distributed between the four test sectors and duration of counts over MAP were progressively lower as the magnitude of boundary change increased. However, taskload and workload were also shown to increase with the increase in aggressiveness and acceptability of the boundary changes decreased. Overall, simulated operations of the DAC concept did not appear to compromise safety. Feedback from the participants highlighted the importance of limiting some aspects of boundary changes such as amount of volume gained or lost and the extent of change relative to the initial airspace design.

EcoEvo-MAPS: An Ecology and Evolution Assessment for Introductory through Advanced Undergraduates.

PubMed

Summers, Mindi M; Couch, Brian A; Knight, Jennifer K; Brownell, Sara E; Crowe, Alison J; Semsar, Katharine; Wright, Christian D; Smith, Michelle K

2018-06-01

A new assessment tool, Ecology and Evolution-Measuring Achievement and Progression in Science or EcoEvo-MAPS, measures student thinking in ecology and evolution during an undergraduate course of study. EcoEvo-MAPS targets foundational concepts in ecology and evolution and uses a novel approach that asks students to evaluate a series of predictions, conclusions, or interpretations as likely or unlikely to be true given a specific scenario. We collected evidence of validity and reliability for EcoEvo-MAPS through an iterative process of faculty review, student interviews, and analyses of assessment data from more than 3000 students at 34 associate's-, bachelor's-, master's-, and doctoral-granting institutions. The 63 likely/unlikely statements range in difficulty and target student understanding of key concepts aligned with the Vision and Change report. This assessment provides departments with a tool to measure student thinking at different time points in the curriculum and provides data that can be used to inform curricular and instructional modifications.

78 FR 60226 - Amendments To Implement Certain Provisions of the Moving Ahead for Progress in the 21st Century...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... Moving Ahead for Progress in the 21st Century Act (MAP-21) AGENCY: Federal Motor Carrier Safety...) adopts, as final, certain regulations required by the Moving Ahead for Progress in the 21st Century... required by MAP-21. Benefits and Costs The rule provisions considered both individually and in the...

Assessment of myocardial fibrosis with T1 mapping MRI.

PubMed

Everett, R J; Stirrat, C G; Semple, S I R; Newby, D E; Dweck, M R; Mirsadraee, S

2016-08-01

Myocardial fibrosis can arise from a range of pathological processes and its presence correlates with adverse clinical outcomes. Cardiac magnetic resonance (CMR) can provide a non-invasive assessment of cardiac structure, function, and tissue characteristics, which includes late gadolinium enhancement (LGE) techniques to identify focal irreversible replacement fibrosis with a high degree of accuracy and reproducibility. Importantly the presence of LGE is consistently associated with adverse outcomes in a range of common cardiac conditions; however, LGE techniques are qualitative and unable to detect diffuse myocardial fibrosis, which is an earlier form of fibrosis preceding replacement fibrosis that may be reversible. Novel T1 mapping techniques allow quantitative CMR assessment of diffuse myocardial fibrosis with the two most common measures being native T1 and extracellular volume (ECV) fraction. Native T1 differentiates normal from infarcted myocardium, is abnormal in hypertrophic cardiomyopathy, and may be particularly useful in the diagnosis of Anderson-Fabry disease and amyloidosis. ECV is a surrogate measure of the extracellular space and is equivalent to the myocardial volume of distribution of the gadolinium-based contrast medium. It is reproducible and correlates well with fibrosis on histology. ECV is abnormal in patients with cardiac failure and aortic stenosis, and is associated with functional impairment in these groups. T1 mapping techniques promise to allow earlier detection of disease, monitor disease progression, and inform prognosis; however, limitations remain. In particular, reference ranges are lacking for T1 mapping values as these are influenced by specific CMR techniques and magnetic field strength. In addition, there is significant overlap between T1 mapping values in healthy controls and most disease states, particularly using native T1, limiting the clinical application of these techniques at present. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Quantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival

PubMed Central

Hattingen, Elke; Jurcoane, Alina; Daneshvar, Keivan; Pilatus, Ulrich; Mittelbronn, Michel; Steinbach, Joachim P.; Bähr, Oliver

2013-01-01

Background Anti-angiogenic treatment in recurrent glioblastoma patients suppresses contrast enhancement and reduces vasogenic edema while non-enhancing tumor progression is common. Thus, the importance of T2-weighted imaging is increasing. We therefore quantified T2 relaxation times, which are the basis for the image contrast on T2-weighted images. Methods Conventional and quantitative MRI procedures were performed on 18 patients with recurrent glioblastoma before treatment with bevacizumab and every 8 weeks thereafter until further tumor progression. We segmented the tumor on conventional MRI into 3 subvolumes: enhancing tumor, non-enhancing tumor, and edema. Using coregistered quantitative maps, we followed changes in T2 relaxation time in each subvolume. Moreover, we generated differential T2 maps by a voxelwise subtraction using the first T2 map under bevacizumab as reference. Results Visually segmented areas of tumor and edema did not differ in T2 relaxation times. Non-enhancing tumor volume did not decrease after commencement of bevacizumab treatment but strikingly increased at progression. Differential T2 maps clearly showed non-enhancing tumor progression in previously normal brain. T2 relaxation times decreased under bevacizumab without re-increasing at tumor progression. A decrease of <26 ms in the enhancing tumor following exposure to bevacizumab was associated with longer overall survival. Conclusions Combining quantitative MRI and tumor segmentation improves monitoring of glioblastoma patients under bevacizumab. The degree of change in T2 relaxation time under bevacizumab may be an early response parameter predictive of overall survival. The sustained decrease in T2 relaxation times toward values of healthy tissue masks progressive tumor on conventional T2-weighted images. Therefore, quantitative T2 relaxation times may detect non-enhancing progression better than conventional T2-weighted imaging. PMID:23925453

Recent progress in the imaging of soil processes at the microscopic scale, and a look ahead

NASA Astrophysics Data System (ADS)

Garnier, Patricia; Baveye, Philippe C.; Pot, Valérie; Monga, Olivier; Portell, Xavier

2016-04-01

Over the last few years, tremendous progress has been achieved in the visualization of soil structures at the microscopic scale. Computed tomography, based on synchrotron X-ray beams or table-top equipment, allows the visualization of pore geometry at micrometric resolution. Chemical and microbiological information obtainable in 2D cuts through soils can now be interpolated, with the support of CT-data, to produce 3-dimensional maps. In parallel with these analytical advances, significant progress has also been achieved in the computer simulation and visualization of a range of physical, chemical, and microbiological processes taking place in soil pores. In terms of water distribution and transport in soils, for example, the use of Lattice-Boltzmann models as well as models based on geometric primitives has been shown recently to reproduce very faithfully observations made with synchrotron X-ray tomography. Coupling of these models with fungal and bacterial growth models allows the description of a range of microbiologically-mediated processes of great importance at the moment, for example in terms of carbon sequestration. In this talk, we shall review progress achieved to date in this field, indicate where questions remain unanswered, and point out areas where further advances are expected in the next few years.

Micro Autonomous Systems and Technology: A Methodology for Quantitative Technology Assessment and Prototyping of Unmanned Vehicles

DTIC Science & Technology

2012-01-30

Sensors: LIDAR , Camera, SONAR) is qualitatively or quantitatively ranked against the other options in such categories as weight and power consumption...Mapping ( SLAM ) and A*. The second software change in progress is upgrading from Unreal 2004 to is a bridge between an external program that defines a...current simulation setup, a simulated quad-copter with an Inertial Navigation System (INS) and ranging LIDAR sensor spawns within an environment and

Remote sensing of air pollution over large European cities by lidar

NASA Astrophysics Data System (ADS)

Koelsch, Hans J.; Kolenda, Juergen; Rairoux, Patrick; Stein, Bernhard; Weidauer, Dirk; Wolf, Jean-Pierre; Woeste, Ludger H.; Fritzsche, Klaus

1993-09-01

Progresses in remote sensing of the atmosphere using the Udar (Light detection and ranging) technique closely follows progresses in Laser technology. We developed a mobile DIAL (differential absorption Lidar) system, based on high repetition rate Excimerpumped dye lasers, for performing 2D and 3D-mappings of concentration of NO, N02, S02, and 03. The high sensitivity of the system has been used for numerous environmental studies and measurement campaigns, providing for the first time a direct correlation between emission and immission. Attractive results have been obtained under urban conditions, because of the presence of strong concentration gradients, and fast fluctuations due to traffic. A comparative study between Lyon, Stuttgart, Geneva and Berlin will be presented. In particular, the Berlin-campaign demonstrates the possibility of detecting unknown emitters and monitoring exportation-importation processes of atmospheric pollution. A new stationary DIAL system has been recently constructed and implemented on the top of a building in the center of the city Leipzig. It will routinely perform concentration mappings of nitrogen oxides, sulfur dioxide and ozone, giving access to long term evolution of pollution distributions.

Method and system for progressive mesh storage and reconstruction using wavelet-encoded height fields

NASA Technical Reports Server (NTRS)

Baxes, Gregory A. (Inventor); Linger, Timothy C. (Inventor)

2011-01-01

Systems and methods are provided for progressive mesh storage and reconstruction using wavelet-encoded height fields. A method for progressive mesh storage includes reading raster height field data, and processing the raster height field data with a discrete wavelet transform to generate wavelet-encoded height fields. In another embodiment, a method for progressive mesh storage includes reading texture map data, and processing the texture map data with a discrete wavelet transform to generate wavelet-encoded texture map fields. A method for reconstructing a progressive mesh from wavelet-encoded height field data includes determining terrain blocks, and a level of detail required for each terrain block, based upon a viewpoint. Triangle strip constructs are generated from vertices of the terrain blocks, and an image is rendered utilizing the triangle strip constructs. Software products that implement these methods are provided.

Method and system for progressive mesh storage and reconstruction using wavelet-encoded height fields

NASA Technical Reports Server (NTRS)

Baxes, Gregory A. (Inventor)

2010-01-01

Systems and methods are provided for progressive mesh storage and reconstruction using wavelet-encoded height fields. A method for progressive mesh storage includes reading raster height field data, and processing the raster height field data with a discrete wavelet transform to generate wavelet-encoded height fields. In another embodiment, a method for progressive mesh storage includes reading texture map data, and processing the texture map data with a discrete wavelet transform to generate wavelet-encoded texture map fields. A method for reconstructing a progressive mesh from wavelet-encoded height field data includes determining terrain blocks, and a level of detail required for each terrain block, based upon a viewpoint. Triangle strip constructs are generated from vertices of the terrain blocks, and an image is rendered utilizing the triangle strip constructs. Software products that implement these methods are provided.

Corneal Densitometry as a Tool to Measure Epithelial Ingrowth After Laser In Situ Keratomileusis.

PubMed

Adran, Daniel; Vaillancourt, Louis; Harissi-Dagher, Mona; Kruh, Jonathan N; Syed, Zeba A; Robinson, Steven; Melki, Samir

2017-04-01

This study evaluates the correlation between corneal densitometry and epithelial ingrowth (EI) after laser in situ keratomileusis (LASIK). Corneal densitometry of 3 patients who developed EI after LASIK was measured with the Oculus Pentacam. Corneal densitometry readings of each patient were obtained preoperatively and postoperatively after ingrowth was discovered. Densitometry was recorded at the central nest of opacity and at the leading edges of EI. For all patients, the most severe stages of EI observed on slit-lamp photographs correlated with the highest densitometry readings, with peak densitometry ranging from 73.3 to 95.1. These values were much higher than preoperative densitometry readings, which ranged from 21.8 to 27.2. In 2 cases, the Pentacam densitometry map revealed progression of EI toward the visual axis that was only faintly detectable or not detectable at all on the corresponding slit-lamp photographs. Corneal densitometry seems to be an objective measure of the severity and progression of EI after LASIK.

Bose-Einstein condensation in chains with power-law hoppings: Exact mapping on the critical behavior in d-dimensional regular lattices.

PubMed

Dias, W S; Bertrand, D; Lyra, M L

2017-06-01

Recent experimental progress on the realization of quantum systems with highly controllable long-range interactions has impelled the study of quantum phase transitions in low-dimensional systems with power-law couplings. Long-range couplings mimic higher-dimensional effects in several physical contexts. Here, we provide the exact relation between the spectral dimension d at the band bottom and the exponent α that tunes the range of power-law hoppings of a one-dimensional ideal lattice Bose gas. We also develop a finite-size scaling analysis to obtain some relevant critical exponents and the critical temperature of the BEC transition. In particular, an irrelevant dangerous scaling field has to be taken into account when the hopping range is sufficiently large to make the effective dimensionality d>4.

Bose-Einstein condensation in chains with power-law hoppings: Exact mapping on the critical behavior in d -dimensional regular lattices

NASA Astrophysics Data System (ADS)

Dias, W. S.; Bertrand, D.; Lyra, M. L.

2017-06-01

Recent experimental progress on the realization of quantum systems with highly controllable long-range interactions has impelled the study of quantum phase transitions in low-dimensional systems with power-law couplings. Long-range couplings mimic higher-dimensional effects in several physical contexts. Here, we provide the exact relation between the spectral dimension d at the band bottom and the exponent α that tunes the range of power-law hoppings of a one-dimensional ideal lattice Bose gas. We also develop a finite-size scaling analysis to obtain some relevant critical exponents and the critical temperature of the BEC transition. In particular, an irrelevant dangerous scaling field has to be taken into account when the hopping range is sufficiently large to make the effective dimensionality d >4 .

Detailed geomorphological mapping from high resolution DEM data (LiDAR, TanDEM-X): two case studies from Germany and SE Tibet

NASA Astrophysics Data System (ADS)

Loibl, D.

2012-04-01

Two major obstacles are hampering the production of high resolution geomorphological maps: the complexity of the subject that should be depicted and the enormous efforts necessary to obtain data by field work. The first factor prevented the establishment of a generally accepted map legend; the second hampered efforts to collect comprehensive sets of geomorphological data. This left geomorphologists to produce applied maps, focusing on very few layers of information and often not sticking to any of the numerous standards proposed in the second half of the 20th century. Technological progress of the recent years, especially in the fields of digital elevation models, GIS environments, and computational hardware, today offers promising opportunities to overcome the obstacles and to produce detailed geomorphological maps even for remote or inhospitable regions. The feasibility of detailed geomorphological mapping from two new sets of digital elevation data, the 1 m LiDAR DTM provided by Germany's State Surveying Authority and the upcoming TanDEM-X DEM, has been evaluated in two case studies from a low mountain range in Germany and a high mountain range in SE Tibet. The results indicate that most layers of information of classical geomorphological maps (e.g. the German GMK) can be extracted from this data at appropriate scales but that significant differences occur concerning the quality and the grades of certainty of key contents. Generally, an enhancement of the geomorphographical, especially the geomorphometrical, and a weakening of geomorphogenetical contents was observed. From these findings, theoretical, methodological, and cartographical remarks on detailed geomorphological mapping from DEM data in GIS environments were educed. As GIS environments decouple data and design and enable the geomorphologist to choose information layer combinations freely to fit research topics, a general purpose legend becomes obsolete. Yet, a unified data structure is demanded to ensure that data collected by different scientists or in different studies can be exchanged and reused.

True progression versus pseudoprogression in the treatment of glioblastomas: a comparison study of normalized cerebral blood volume and apparent diffusion coefficient by histogram analysis.

PubMed

Song, Yong Sub; Choi, Seung Hong; Park, Chul-Kee; Yi, Kyung Sik; Lee, Woong Jae; Yun, Tae Jin; Kim, Tae Min; Lee, Se-Hoon; Kim, Ji-Hoon; Sohn, Chul-Ho; Park, Sung-Hye; Kim, Il Han; Jahng, Geon-Ho; Chang, Kee-Hyun

2013-01-01

The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. Twenty patients with histopathologically proven glioblastoma who had received CCRT with TMZ underwent perfusion-weighted imaging and diffusion-weighted imaging (b = 0, 1000 sec/mm(2)). The corresponding nCBV and ADC maps for the newly visible, entirely enhancing lesions were calculated after the completion of CCRT with TMZ. Two observers independently measured the histogram parameters of the nCBV and ADC maps. The histogram parameters between the true progression group (n = 10) and the pseudoprogression group (n = 10) were compared by use of an unpaired Student's t test and subsequent multivariable stepwise logistic regression analysis to determine the best predictors for the differential diagnosis between the two groups. Receiver operating characteristic analysis was employed to determine the best cutoff values for the histogram parameters that proved to be significant predictors for differentiating true progression from pseudoprogression. Intraclass correlation coefficient was used to determine the level of inter-observer reliability for the histogram parameters. The 5th percentile value (C5) of the cumulative ADC histograms was a significant predictor for the differential diagnosis between true progression and pseudoprogression (p = 0.044 for observer 1; p = 0.011 for observer 2). Optimal cutoff values of 892 × 10(-6) mm(2)/sec for observer 1 and 907 × 10(-6) mm(2)/sec for observer 2 could help differentiate between the two groups with a sensitivity of 90% and 80%, respectively, a specificity of 90% and 80%, respectively, and an area under the curve of 0.880 and 0.840, respectively. There was no other significant differentiating parameter on the nCBV histograms. Inter-observer reliability was excellent or good for all histogram parameters (intraclass correlation coefficient range: 0.70-0.99). The C5 of the cumulative ADC histogram can be a promising parameter for the differentiation of true progression from pseudoprogression of newly visible, entirely enhancing lesions after CCRT with TMZ for glioblastomas.

True Progression versus Pseudoprogression in the Treatment of Glioblastomas: A Comparison Study of Normalized Cerebral Blood Volume and Apparent Diffusion Coefficient by Histogram Analysis

PubMed Central

Song, Yong Sub; Park, Chul-Kee; Yi, Kyung Sik; Lee, Woong Jae; Yun, Tae Jin; Kim, Tae Min; Lee, Se-Hoon; Kim, Ji-Hoon; Sohn, Chul-Ho; Park, Sung-Hye; Kim, Il Han; Jahng, Geon-Ho; Chang, Kee-Hyun

2013-01-01

Objective The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. Materials and Methods Twenty patients with histopathologically proven glioblastoma who had received CCRT with TMZ underwent perfusion-weighted imaging and diffusion-weighted imaging (b = 0, 1000 sec/mm2). The corresponding nCBV and ADC maps for the newly visible, entirely enhancing lesions were calculated after the completion of CCRT with TMZ. Two observers independently measured the histogram parameters of the nCBV and ADC maps. The histogram parameters between the true progression group (n = 10) and the pseudoprogression group (n = 10) were compared by use of an unpaired Student's t test and subsequent multivariable stepwise logistic regression analysis to determine the best predictors for the differential diagnosis between the two groups. Receiver operating characteristic analysis was employed to determine the best cutoff values for the histogram parameters that proved to be significant predictors for differentiating true progression from pseudoprogression. Intraclass correlation coefficient was used to determine the level of inter-observer reliability for the histogram parameters. Results The 5th percentile value (C5) of the cumulative ADC histograms was a significant predictor for the differential diagnosis between true progression and pseudoprogression (p = 0.044 for observer 1; p = 0.011 for observer 2). Optimal cutoff values of 892 × 10-6 mm2/sec for observer 1 and 907 × 10-6 mm2/sec for observer 2 could help differentiate between the two groups with a sensitivity of 90% and 80%, respectively, a specificity of 90% and 80%, respectively, and an area under the curve of 0.880 and 0.840, respectively. There was no other significant differentiating parameter on the nCBV histograms. Inter-observer reliability was excellent or good for all histogram parameters (intraclass correlation coefficient range: 0.70-0.99). Conclusion The C5 of the cumulative ADC histogram can be a promising parameter for the differentiation of true progression from pseudoprogression of newly visible, entirely enhancing lesions after CCRT with TMZ for glioblastomas. PMID:23901325

Chromosomal Mapping of Canine-Derived BAC Clones to the Red Fox and American Mink Genomes

PubMed Central

Vorobieva, Nadegda V.; Beklemisheva, Violetta R.; Johnson, Jennifer L.; Temnykh, Svetlana V.; Yudkin, Dmitry V.; Trut, Lyudmila N.; Andre, Catherine; Galibert, Francis; Aguirre, Gustavo D.; Acland, Gregory M.; Graphodatsky, Alexander S.

2009-01-01

High-quality sequencing of the dog (Canis lupus familiaris) genome has enabled enormous progress in genetic mapping of canine phenotypic variation. The red fox (Vulpes vulpes), another canid species, also exhibits a wide range of variation in coat color, morphology, and behavior. Although the fox genome has not yet been sequenced, canine genomic resources have been used to construct a meiotic linkage map of the red fox genome and begin genetic mapping in foxes. However, a more detailed gene-specific comparative map between the dog and fox genomes is required to establish gene order within homologous regions of dog and fox chromosomes and to refine breakpoints between homologous chromosomes of the 2 species. In the current study, we tested whether canine-derived gene–containing bacterial artificial chromosome (BAC) clones can be routinely used to build a gene-specific map of the red fox genome. Forty canine BAC clones were mapped to the red fox genome by fluorescence in situ hybridization (FISH). Each clone was uniquely assigned to a single fox chromosome, and the locations of 38 clones agreed with cytogenetic predictions. These results clearly demonstrate the utility of FISH mapping for construction of a whole-genome gene-specific map of the red fox. The further possibility of using canine BAC clones to map genes in the American mink (Mustela vison) genome was also explored. Much lower success was obtained for this more distantly related farm-bred species, although a few BAC clones were mapped to the predicted chromosomal locations. PMID:19546120

Chromosomal mapping of canine-derived BAC clones to the red fox and American mink genomes.

PubMed

Kukekova, Anna V; Vorobieva, Nadegda V; Beklemisheva, Violetta R; Johnson, Jennifer L; Temnykh, Svetlana V; Yudkin, Dmitry V; Trut, Lyudmila N; Andre, Catherine; Galibert, Francis; Aguirre, Gustavo D; Acland, Gregory M; Graphodatsky, Alexander S

2009-01-01

High-quality sequencing of the dog (Canis lupus familiaris) genome has enabled enormous progress in genetic mapping of canine phenotypic variation. The red fox (Vulpes vulpes), another canid species, also exhibits a wide range of variation in coat color, morphology, and behavior. Although the fox genome has not yet been sequenced, canine genomic resources have been used to construct a meiotic linkage map of the red fox genome and begin genetic mapping in foxes. However, a more detailed gene-specific comparative map between the dog and fox genomes is required to establish gene order within homologous regions of dog and fox chromosomes and to refine breakpoints between homologous chromosomes of the 2 species. In the current study, we tested whether canine-derived gene-containing bacterial artificial chromosome (BAC) clones can be routinely used to build a gene-specific map of the red fox genome. Forty canine BAC clones were mapped to the red fox genome by fluorescence in situ hybridization (FISH). Each clone was uniquely assigned to a single fox chromosome, and the locations of 38 clones agreed with cytogenetic predictions. These results clearly demonstrate the utility of FISH mapping for construction of a whole-genome gene-specific map of the red fox. The further possibility of using canine BAC clones to map genes in the American mink (Mustela vison) genome was also explored. Much lower success was obtained for this more distantly related farm-bred species, although a few BAC clones were mapped to the predicted chromosomal locations.

Modelling of high-frequency structure-borne sound transmission on FEM grids using the Discrete Flow Mapping technique

NASA Astrophysics Data System (ADS)

Hartmann, Timo; Tanner, Gregor; Xie, Gang; Chappell, David; Bajars, Janis

2016-09-01

Dynamical Energy Analysis (DEA) combined with the Discrete Flow Mapping technique (DFM) has recently been introduced as a mesh-based high frequency method modelling structure borne sound for complex built-up structures. This has proven to enhance vibro-acoustic simulations considerably by making it possible to work directly on existing finite element meshes circumventing time-consuming and costly re-modelling strategies. In addition, DFM provides detailed spatial information about the vibrational energy distribution within a complex structure in the mid-to-high frequency range. We will present here progress in the development of the DEA method towards handling complex FEM-meshes including Rigid Body Elements. In addition, structure borne transmission paths due to spot welds are considered. We will present applications for a car floor structure.

Technical Adequacy and Acceptability of Curriculum-Based Measurement and the Measures of Academic Progress

ERIC Educational Resources Information Center

January, Stacy-Ann A.; Ardoin, Scott P.

2015-01-01

Curriculum-based measurement in reading (CBM-R) and the Measures of Academic Progress (MAP) are assessment tools widely employed for universal screening in schools. Although a large body of research supports the validity of CBM-R, limited empirical evidence exists supporting the technical adequacy of MAP or the acceptability of either measure for…

Evaluate ERTS imagery for mapping and detection of changes of snowcover on land and on glaciers. [Washington, Alaska, British Columbia, and U.S.S.R.

NASA Technical Reports Server (NTRS)

Meier, M. F. (Principal Investigator)

1973-01-01

The author has identified the following significant results. The standard error of measurement of snow covered areas in major drainage basins in the Cascade Range, Washington, using single measurements of ERTS-1 images, was found to range from 11% to 7% during a typical melt season, but was as high as 32% in midwinter. Many dangerous glacier situations in Alaska, Yukon, and British Columbia were observed on ERTS-1 imagery. Glacier dammed lakes in Alaska are being monitored by ERTS-1. Embayments in tidal glaciers show changes detectable by ERTS-1. Surges of Russell and Tweedsmuir Glaciers, now in progress, are clearly visible. The Tweedsmuir surge is likely to dam the large Alsek River by mid-November, producing major floods down-river next summer. An ERTS-1 image of the Pamir Mountains, Tadjik S.S.R., shows the surging Medvezhii (Bear) Glacier just after its surge of early summer which dammed the Abdukagor Valley creating a huge lake and later a flood in the populous Vanch River Valley. A map was compiled from an ERTS-1 image of the Lowell Glacier after its recent surge, compared with an earlier map compiled from pain-stakingly compiled from a mosaic of many aerial photographs, in a total elapsed time of 1.5 hours. This demonstrates the value of ERTS-1 for rapid mapping of large features.

Remote sensing of air pollution over large European cities by lidar

NASA Astrophysics Data System (ADS)

Koelsch, Hans J.; Kolenda, Juergen; Rairoux, Patrick; Stein, Bernhard; Weidauer, Dirk; Wolf, Jean-Pierre; Woeste, Ludger H.; Fritzsche, Klaus

1992-12-01

Progresses in remote sensing of the atmosphere using the light detection and ranging (lidar) technique closely follows progresses in laser technology. We developed a mobile differential absorption lidar (DIAL) system, based on high repetition rate excimer-pumped dye lasers, for performing 2-D and 3-D mappings of concentration of NO, NO2, SO2, and O3. The high sensitivity of the system has been used for numerous environmental studies and measurement campaigns, providing for the first time a direct correlation between emission and immission. Attractive results have been obtained under urban conditions, because of the presence of strong concentration gradients, and fast fluctuations due to traffic. A comparative study between Lyon, France; Stuttgart, Germany; Geneva, Switzerland; and Berlin, Germany; is presented. In particular, the Berlin campaign demonstrates the possibility of detecting unknown emitters and monitoring exportation-importation processes of atmospheric pollution. A new stationary DIAL system has recently been constructed and implemented on the top of a building in the center of the city of Leipzig, Germany. It will routinely perform concentration mappings of nitrogen oxides, sulfur dioxide, and ozone, giving access to long term evolution of pollution distributions.

Inferring biomarkers for Mycobacterium avium subsp. paratuberculosis infection and disease progression in cattle using experimental data

NASA Astrophysics Data System (ADS)

Magombedze, Gesham; Shiri, Tinevimbo; Eda, Shigetoshi; Stabel, Judy R.

2017-03-01

Available diagnostic assays for Mycobacterium avium subsp. paratuberculosis (MAP) have poor sensitivities and cannot detect early stages of infection, therefore, there is need to find new diagnostic markers for early infection detection and disease stages. We analyzed longitudinal IFN-γ, ELISA-antibody and fecal shedding experimental sensitivity scores for MAP infection detection and disease progression. We used both statistical methods and dynamic mathematical models to (i) evaluate the empirical assays (ii) infer and explain biological mechanisms that affect the time evolution of the biomarkers, and (iii) predict disease stages of 57 animals that were naturally infected with MAP. This analysis confirms that the fecal test is the best marker for disease progression and illustrates that Th1/Th2 (IFN-γ/ELISA antibodies) assays are important for infection detection, but cannot reliably predict persistent infections. Our results show that the theoretical simulated macrophage-based assay is a potential good diagnostic marker for MAP persistent infections and predictor of disease specific stages. We therefore recommend specifically designed experiments to test the use of a based assay in the diagnosis of MAP infections.

Mapping with Young Children.

ERIC Educational Resources Information Center

Sunal, Cynthia Szymanski; Warash, Bobbi Gibson

Techniques for encouraging young children to discover the purpose and use of maps are discussed. Motor activity and topological studies form a base from which the teacher and children can build a mapping program of progressive sophistication. Concepts important to mapping include boundaries, regions, exteriors, interiors, holes, order, point of…

How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

PubMed

van Vliet, Liesbeth M; Gao, Wei; DiFrancesco, Daniel; Crosby, Vincent; Wilcock, Andrew; Byrne, Anthony; Al-Chalabi, Ammar; Chaudhuri, K Ray; Evans, Catherine; Silber, Eli; Young, Carolyn; Malik, Farida; Quibell, Rachel; Higginson, Irene J

2016-05-10

Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to map the current level of connections and integration between these services. The mapping exercise was conducted in eight centres with neurology and palliative care services in the United Kingdom. The data were provided by the respective neurology and specialist palliative care teams. Questions focused on: i) catchment and population served; ii) service provision and staffing; iii) integration and relationships. Centres varied in size of catchment areas (39-5,840 square miles) and population served (142,000-3,500,000). Neurology and specialist palliative care were often not co-terminus. Service provisions for neurology and specialist palliative care were also varied. For example, neurology services varied in the number and type of provided clinics and palliative care services in the settings they work in. Integration was most developed in Motor Neuron Disease (MND), e.g., joint meetings were often held, followed by Parkinsonism (made up of Parkinson's Disease (PD), Multiple-System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), with integration being more developed for MSA and PSP) and least in Multiple Sclerosis (MS), e.g., most sites had no formal links. The number of neurology patients per annum receiving specialist palliative care reflected these differences in integration (range: 9-88 MND, 3-25 Parkinsonism, and 0-5 MS). This mapping exercise showed heterogeneity in service provision and integration between neurology and specialist palliative care services, which varied not only between sites but also between diseases. This highlights the need and opportunities for improved models of integration, which should be rigorously tested for effectiveness.

Construct Validity and Measurement Invariance of Computerized Adaptive Testing: Application to Measures of Academic Progress (MAP) Using Confirmatory Factor Analysis

ERIC Educational Resources Information Center

Wang, Shudong; McCall, Marty; Jiao, Hong; Harris, Gregg

2012-01-01

The purposes of this study are twofold. First, to investigate the construct or factorial structure of a set of Reading and Mathematics computerized adaptive tests (CAT), "Measures of Academic Progress" (MAP), given in different states at different grades and academic terms. The second purpose is to investigate the invariance of test…

Depletion of CD4 T Lymphocytes at the time of infection with M. avium subsp. paratuberculosis does not accelerate disease progression

USDA-ARS?s Scientific Manuscript database

A calf model was used to determine if the depletion of CD4 T cells prior to inoculation of Mycobacterium avium subsp. paratuberculosis (Map) would delay development of an immune response to Map and accelerate disease progression. Ileal cannulas were surgically implanted in 5 bull calves at two month...

A Road Map for Learning Progressions Research in Geography

ERIC Educational Resources Information Center

Huynh, Niem Tu; Solem, Michael; Bednarz, Sarah Witham

2015-01-01

This article provides an overview of learning progressions (LP) and assesses the potential of this line of research to improve geography education. It presents the merits and limitations of three of the most common approaches used to conduct LP research and draws on one approach to propose a first draft of a LP on map reading and interpretation.…

Evaluation of MRI sequences for quantitative T1 brain mapping

NASA Astrophysics Data System (ADS)

Tsialios, P.; Thrippleton, M.; Glatz, A.; Pernet, C.

2017-11-01

T1 mapping constitutes a quantitative MRI technique finding significant application in brain imaging. It allows evaluation of contrast uptake, blood perfusion, volume, providing a more specific biomarker of disease progression compared to conventional T1-weighted images. While there are many techniques for T1-mapping there is a wide range of reported T1-values in tissues, raising the issue of protocols reproducibility and standardization. The gold standard for obtaining T1-maps is based on acquiring IR-SE sequence. Widely used alternative sequences are IR-SE-EPI, VFA (DESPOT), DESPOT-HIFI and MP2RAGE that speed up scanning and fitting procedures. A custom MRI phantom was used to assess the reproducibility and accuracy of the different methods. All scans were performed using a 3T Siemens Prisma scanner. The acquired data processed using two different codes. The main difference was observed for VFA (DESPOT) which grossly overestimated T1 relaxation time by 214 ms [126 270] compared to the IR-SE sequence. MP2RAGE and DESPOT-HIFI sequences gave slightly shorter time than IR-SE (~20 to 30ms) and can be considered as alternative and time-efficient methods for acquiring accurate T1 maps of the human brain, while IR-SE-EPI gave identical result, at a cost of a lower image quality.

Mapping the Natchez Trace Parkway

USGS Publications Warehouse

Rangoonwala, Amina; Bannister, Terri; Ramsey, Elijah W.

2011-01-01

Based on a National Park Service (NPS) landcover classification, a landcover map of the 715-km (444-mile) NPS Natchez Trace Parkway (hereafter referred to as the "Parkway") was created. The NPS landcover classification followed National Vegetation Classification (NVC) protocols. The landcover map, which extended the initial landcover classification to the entire Parkway, was based on color-infrared photography converted to 1-m raster-based digital orthophoto quarter quadrangles, according to U.S. Geological Survey mapping standards. Our goal was to include as many alliance classes as possible in the Parkway landcover map. To reach this goal while maintaining a consistent and quantifiable map product throughout the Parkway extent, a mapping strategy was implemented based on the migration of class-based spectral textural signatures and the congruent progressive refinement of those class signatures along the Parkway. Progressive refinement provided consistent mapping by evaluating the spectral textural distinctiveness of the alliance-association classes, and where necessary, introducing new map classes along the Parkway. By following this mapping strategy, the use of raster-based image processing and geographic information system analyses for the map production provided a quantitative and reproducible product. Although field-site classification data were severely limited, the combination of spectral migration of class membership along the Parkway and the progressive classification strategy produced an organization of alliances that was internally highly consistent. The organization resulted from the natural patterns or alignments of spectral variance and the determination of those spectral patterns that were compositionally similar in the dominant species as NVC alliances. Overall, the mapped landcovers represented the existent spectral textural patterns that defined and encompassed the complex variety of compositional alliances and associations of the Parkway. Based on that mapped representation, forests dominate the Parkway landscape. Grass is the second largest Parkway land cover, followed by scrub-shrub and shrubland classes and pine plantations. The map provides a good representation of the landcover patterns and their changes over the extent of the Parkway, south to north.

Three-dimensional quantitative T1 and T2 mapping of the carotid artery: Sequence design and in vivo feasibility.

PubMed

Coolen, Bram F; Poot, Dirk H J; Liem, Madieke I; Smits, Loek P; Gao, Shan; Kotek, Gyula; Klein, Stefan; Nederveen, Aart J

2016-03-01

A novel three-dimensional (3D) T1 and T2 mapping protocol for the carotid artery is presented. A 3D black-blood imaging sequence was adapted allowing carotid T1 and T2 mapping using multiple flip angles and echo time (TE) preparation times. B1 mapping was performed to correct for spatially varying deviations from the nominal flip angle. The protocol was optimized using simulations and phantom experiments. In vivo scans were performed on six healthy volunteers in two sessions, and in a patient with advanced atherosclerosis. Compensation for patient motion was achieved by 3D registration of the inter/intrasession scans. Subsequently, T1 and T2 maps were obtained by maximum likelihood estimation. Simulations and phantom experiments showed that the bias in T1 and T2 estimation was < 10% within the range of physiological values. In vivo T1 and T2 values for carotid vessel wall were 844 ± 96 and 39 ± 5 ms, with good repeatability across scans. Patient data revealed altered T1 and T2 values in regions of atherosclerotic plaque. The 3D T1 and T2 mapping of the carotid artery is feasible using variable flip angle and variable TE preparation acquisitions. We foresee application of this technique for plaque characterization and monitoring plaque progression in atherosclerotic patients. © 2015 Wiley Periodicals, Inc.

Cellular and genetic regulation of the development of the cerebellar system.

PubMed

Sotelo, Constantino

2004-04-01

Recent advances in molecular biology have drastically changed our vision on the development of the nervous system, the cerebellum in particular. After a classical descriptive period, we are now in a modern mechanistic epoch as we begin to answer crucial questions in our quest to understand the mechanisms underlying the emergence of brain complexity. This review begins with an analysis of the role of the "isthmic organizer" in the induction and specification of the cerebellar territory and progresses through cerebellar development to the formation of cerebellar maps. It gathers information about the control of the proliferation of granule cell precursors by Purkinje cells and the role of Shh/Gli-patched signaling. The migratory routes for cerebellar and precerebellar neurons, together with the long-range and short-range cues guiding gliophilic and, particularly, neurophilic migrations, are also discussed. Because these cues are similar to those involved in axon guidance, both processes are under the same molecular constraints. Finally, using primarily the olivocerebellar projection as a model, the cellular and molecular mechanisms involved in the formation of cerebellar maps are discussed. During embryonic development, Purkinje cells in the cerebellum and neurons in the inferior olive follow a simultaneous, but independent, process of intrinsic parcellation, giving rise to subsets of biochemically different cortical compartments. The occurrence of positional information shared between olivary axons and their postsynaptic targets, the Purkinje cells, provides a molecular code for the formation of coarse-grained maps. Activity-dependent mechanisms are required for the transition from crude to fine-grained maps. This important refinement, which confers ultimate specificity to the maps, is under the regulation of parallel fiber-Purkinje cell synaptic activity.

Geology of Holden Crater and the Holden and Ladon Multi-Ring Impact Basins, Margaritifer Terra, Mars

NASA Technical Reports Server (NTRS)

Irwin, R. P., III; Grant, J. A.

2008-01-01

Geologic mapping at 1:500K scale of Mars quads 15s027, 20s027, 25s027, and 25s032 (Fig. 1) is in progress to constrain the geologic and geomorphic history of southwestern Margaritifer Terra. This work builds on earlier maps at 1:5M [1] and 1:15M scales [2], recent to concurrent 1:500Kscale mapping of adjacent areas to the east [3-5], and studies of drainage basin evolution along the Uzboi-Ladon-M (ULM; the third valley in the sequence has no formal name) Valles basin overflow system and nearby watersheds [6-9]. Two of the six landing sites under consideration for the Mars Science Laboratory rover are in this map area, targeting finely layered, phyllosilicate-rich strata and alluvial fans in Holden crater [10-12] (26degS, 34degW, 150 km diameter) or deposits southeast of a likely delta in Eberswalde crater [13-16] (24degS, 33degW, 50 km in diameter). Diverse processes including larger and smaller impacts, a wide range in fluvial activity, and local to regional structural influences have all affected the surface morphology.

A Carbon Monitoring System Approach to US Coastal Wetland Carbon Fluxes: Progress Towards a Tier II Accounting Method with Uncertainty Quantification

NASA Astrophysics Data System (ADS)

Windham-Myers, L.; Holmquist, J. R.; Bergamaschi, B. A.; Byrd, K. B.; Callaway, J.; Crooks, S.; Drexler, J. Z.; Feagin, R. A.; Ferner, M. C.; Gonneea, M. E.; Kroeger, K. D.; Megonigal, P.; Morris, J. T.; Schile, L. M.; Simard, M.; Sutton-Grier, A.; Takekawa, J.; Troxler, T.; Weller, D.; Woo, I.

2015-12-01

Despite their high rates of long-term carbon (C) sequestration when compared to upland ecosystems, coastal C accounting is only recently receiving the attention of policy makers and carbon markets. Assessing accuracy and uncertainty in net C flux estimates requires both direct and derived measurements based on both short and long term dynamics in key drivers, particularly soil accretion rates and soil organic content. We are testing the ability of remote sensing products and national scale datasets to estimate biomass and soil stocks and fluxes over a wide range of spatial and temporal scales. For example, the 2013 Wetlands Supplement to the 2006 IPCC GHG national inventory reporting guidelines requests information on development of Tier I-III reporting, which express increasing levels of detail. We report progress toward development of a Carbon Monitoring System for "blue carbon" that may be useful for IPCC reporting guidelines at Tier II levels. Our project uses a current dataset of publically available and contributed field-based measurements to validate models of changing soil C stocks, across a broad range of U.S. tidal wetland types and landuse conversions. Additionally, development of biomass algorithms for both radar and spectral datasets will be tested and used to determine the "price of precision" of different satellite products. We discuss progress in calculating Tier II estimates focusing on variation introduced by the different input datasets. These include the USFWS National Wetlands Inventory, NOAA Coastal Change Analysis Program, and combinations to calculate tidal wetland area. We also assess the use of different attributes and depths from the USDA-SSURGO database to map soil C density. Finally, we examine the relative benefit of radar, spectral and hybrid approaches to biomass mapping in tidal marshes and mangroves. While the US currently plans to report GHG emissions at a Tier I level, we argue that a Tier II analysis is possible due to national maps of wetland area and soil carbon, as well as sediment accretion and sea-level rise correlations and wetland area change data. The uncertainty analyses performed nationally and in six regionally-representative "sentinel sites" will be an important guide for future efforts towards more accurate and complete wetland C inventories.

Learning Progressions Provide Road Maps for the Development and Validity of Assessments and Curriculum Materials

ERIC Educational Resources Information Center

Krajcik, Joseph

2011-01-01

Paul Black, Mark Wilson, and Shih-Ying Yao in "Road Maps for Learning: A Guide to the Navigation of Learning Progressions" provide a number of important ideas to consider regarding the development of assessments and curriculum materials to support development of core ideas. One major idea that the author found most valuable is the focus on student…

Building a Learning Progression for Celestial Motion: An Exploration of Students' Reasoning about the Seasons

ERIC Educational Resources Information Center

Plummer, Julia D.; Maynard, L.

2014-01-01

We present the development of a construct map addressing the reason for the seasons, as a subset of a larger learning progression on celestial motion. Five classes of 8th grade students (N?=?38) participated in a 10-day curriculum on the seasons. We revised a hypothetical seasons construct map using a Rasch model analysis of students'…

Analysis of the BEV Technology Progress of America, Europe, Japan and Korea Based on Patent Map

NASA Astrophysics Data System (ADS)

Yurong, Huang; Yuanyuan, Hou; Jingyan, Zhou; Ru, Liu

2018-02-01

The paper analyzed the Battery Electric Vehicle patent application trend, major country distribution, main technology layout and patentee of America, Europe, Japan and Korea based on patent information from 2006 to 2016 by using patent map method, and visualized the Battery Electric Vehicle technology progress conditions of the four countries and regions in the last decade.

Toward digital geologic map standards: a progress report

USGS Publications Warehouse

Ulrech, George E.; Reynolds, Mitchell W.; Taylor, Richard B.

1992-01-01

Establishing modern scientific and technical standards for geologic maps and their derivative map products is vital to both producers and users of such maps as we move into an age of digital cartography. Application of earth-science data in complex geographic information systems, acceleration of geologic map production, and reduction of population costs require that national standards be developed for digital geologic cartography and computer analysis. Since December 1988, under commission of the Chief Geologic of the U.S. Geological Survey and the mandate of the National Geologic Mapping Program (with added representation from the Association of American State Geologists), a committee has been designing a comprehensive set of scientific map standards. Three primary issues were: (1) selecting scientific symbology and its digital representation; (2) creating an appropriate digital coding system that characterizes geologic features with respect to their physical properties, stratigraphic and structural relations, spatial orientation, and interpreted mode of origin; and (3) developing mechanisms for reporting levels of certainty for descriptive as well as measured properties. Approximately 650 symbols for geoscience maps, including present usage of the U.S Geological Survey, state geological surveys, industry, and academia have been identified and tentatively adopted. A proposed coding system comprises four-character groupings of major and minor codes that can identify all attributes of a geologic feature. Such a coding system allows unique identification of as many as 105 geologic names and values on a given map. The new standard will track closely the latest developments of the Proposed Standard for Digital Cartographic Data soon to be submitted to the National Institute of Standards and Technology by the Federal Interagency Coordinating Committee on Digital Cartography. This standard will adhere generally to the accepted definitions and specifications for spatial data transfer. It will require separate specifications of digital cartographic quality relating to positional accuracy and ranges of measured and interpreted values such as geologic age and rock composition. Provisional digital geologic map standards will be published for trial implementation. After approximately two years, when comments on the proposed standards have been solicited and modifications made, formal adoption of the standards will be recommended. Widespread acceptance of the new standards will depend on their applicability to the broadest range of earth-science map products and their adaptability to changing cartographic technology.

The Making of the 1:3M Geological Map Series of Mercury: Status and Updates

NASA Astrophysics Data System (ADS)

Galluzzi, V.; Guzzetta, L.; Mancinelli, P.; Giacomini, L.; Lewang, A. M.; Malliband, C.; Mosca, A.; Pegg, D.; Wright, J.; Ferranti, L.; Hiesinger, H.; Massironi, M.; Pauselli, C.; Rothery, D. A.; Palumbo, P.

2018-05-01

A complete global series of 1:3M-scale maps of Mercury is being prepared in support to the ESA/JAXA BepiColombo mission. Currently, 35% of Mercury has been mapped and 55% of the planet will be covered soon by the maps in progress.

QIN DAWG Validation of Gradient Nonlinearity Bias Correction Workflow for Quantitative Diffusion-Weighted Imaging in Multicenter Trials.

PubMed

Malyarenko, Dariya I; Wilmes, Lisa J; Arlinghaus, Lori R; Jacobs, Michael A; Huang, Wei; Helmer, Karl G; Taouli, Bachir; Yankeelov, Thomas E; Newitt, David; Chenevert, Thomas L

2016-12-01

Previous research has shown that system-dependent gradient nonlinearity (GNL) introduces a significant spatial bias (nonuniformity) in apparent diffusion coefficient (ADC) maps. Here, the feasibility of centralized retrospective system-specific correction of GNL bias for quantitative diffusion-weighted imaging (DWI) in multisite clinical trials is demonstrated across diverse scanners independent of the scanned object. Using corrector maps generated from system characterization by ice-water phantom measurement completed in the previous project phase, GNL bias correction was performed for test ADC measurements from an independent DWI phantom (room temperature agar) at two offset locations in the bore. The precomputed three-dimensional GNL correctors were retrospectively applied to test DWI scans by the central analysis site. The correction was blinded to reference DWI of the agar phantom at magnet isocenter where the GNL bias is negligible. The performance was evaluated from changes in ADC region of interest histogram statistics before and after correction with respect to the unbiased reference ADC values provided by sites. Both absolute error and nonuniformity of the ADC map induced by GNL (median, 12%; range, -35% to +10%) were substantially reduced by correction (7-fold in median and 3-fold in range). The residual ADC nonuniformity errors were attributed to measurement noise and other non-GNL sources. Correction of systematic GNL bias resulted in a 2-fold decrease in technical variability across scanners (down to site temperature range). The described validation of GNL bias correction marks progress toward implementation of this technology in multicenter trials that utilize quantitative DWI.

QIN DAWG Validation of Gradient Nonlinearity Bias Correction Workflow for Quantitative Diffusion-Weighted Imaging in Multicenter Trials

PubMed Central

Malyarenko, Dariya I.; Wilmes, Lisa J.; Arlinghaus, Lori R.; Jacobs, Michael A.; Huang, Wei; Helmer, Karl G.; Taouli, Bachir; Yankeelov, Thomas E.; Newitt, David; Chenevert, Thomas L.

2017-01-01

Previous research has shown that system-dependent gradient nonlinearity (GNL) introduces a significant spatial bias (nonuniformity) in apparent diffusion coefficient (ADC) maps. Here, the feasibility of centralized retrospective system-specific correction of GNL bias for quantitative diffusion-weighted imaging (DWI) in multisite clinical trials is demonstrated across diverse scanners independent of the scanned object. Using corrector maps generated from system characterization by ice-water phantom measurement completed in the previous project phase, GNL bias correction was performed for test ADC measurements from an independent DWI phantom (room temperature agar) at two offset locations in the bore. The precomputed three-dimensional GNL correctors were retrospectively applied to test DWI scans by the central analysis site. The correction was blinded to reference DWI of the agar phantom at magnet isocenter where the GNL bias is negligible. The performance was evaluated from changes in ADC region of interest histogram statistics before and after correction with respect to the unbiased reference ADC values provided by sites. Both absolute error and nonuniformity of the ADC map induced by GNL (median, 12%; range, −35% to +10%) were substantially reduced by correction (7-fold in median and 3-fold in range). The residual ADC nonuniformity errors were attributed to measurement noise and other non-GNL sources. Correction of systematic GNL bias resulted in a 2-fold decrease in technical variability across scanners (down to site temperature range). The described validation of GNL bias correction marks progress toward implementation of this technology in multicenter trials that utilize quantitative DWI. PMID:28105469

High-Resolution Geologic Mapping of Martian Terraced Fan Deposits

NASA Astrophysics Data System (ADS)

Wolak, J. M.; Patterson, A. B.; Smith, S. D.; Robbins, N. N.

2018-06-01

This abstract documents our initial progress (year 1) mapping terraced fan features on Mars. Our objective is to investigate the role of fluids during fan formation and produce the first high-resolution geologic map (1:18k) of a terraced fan.

A multi-plate velocity-map imaging design for high-resolution photoelectron spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kregel, Steven J.; Thurston, Glen K.; Zhou, Jia

A velocity map imaging (VMI) setup consisting of multiple electrodes with three adjustable voltage parameters, designed for slow electron velocity map imaging applications, is presented. The motivations for this design are discussed in terms of parameters that influence the VMI resolution and functionality. Particularly, this VMI has two tunable potentials used to adjust for optimal focus, yielding good VMI focus across a relatively large energy range. It also allows for larger interaction volumes without significant sacrifice to the resolution via a smaller electric gradient at the interaction region. All the electrodes in this VMI have the same dimensions for practicalitymore » and flexibility, allowing for relatively easy modifications to suit different experimental needs. We have coupled this VMI to a cryogenic ion trap mass spectrometer that has a flexible source design. The performance is demonstrated with the photoelectron spectra of S- and CS 2 -. The latter has a long vibrational progression in the ground state, and the temperature dependence of the vibronic features is probed by changing the temperature of the ion trap.« less

A multi-plate velocity-map imaging design for high-resolution photoelectron spectroscopy

DOE PAGES

Kregel, Steven J.; Thurston, Glen K.; Zhou, Jia; ...

2017-09-01

A velocity map imaging (VMI) setup consisting of multiple electrodes with three adjustable voltage parameters, designed for slow electron velocity map imaging applications, is presented. The motivations for this design are discussed in terms of parameters that influence the VMI resolution and functionality. Particularly, this VMI has two tunable potentials used to adjust for optimal focus, yielding good VMI focus across a relatively large energy range. It also allows for larger interaction volumes without significant sacrifice to the resolution via a smaller electric gradient at the interaction region. All the electrodes in this VMI have the same dimensions for practicalitymore » and flexibility, allowing for relatively easy modifications to suit different experimental needs. We have coupled this VMI to a cryogenic ion trap mass spectrometer that has a flexible source design. The performance is demonstrated with the photoelectron spectra of S- and CS 2 -. The latter has a long vibrational progression in the ground state, and the temperature dependence of the vibronic features is probed by changing the temperature of the ion trap.« less

The 1973 dust storm on Mars: Maps from hourly photographs

NASA Technical Reports Server (NTRS)

Martin, L. J.

1975-01-01

The hourly progress of the 1973 major Martian storm was mapped using photographic images from the International Planetary Patrol. Two series of 20 daily maps show the semi-hourly positions of the storm brightenings in red light and blue light. The maps indicate that the 1973 storm had many similarities to the 1971 storm.

Geologic Mapping of Impact Craters and the Mahuea Tholus Construct: A Year Three Progress Report for the Mahuea Tholus (V-49) Quadrangle, Venus

NASA Astrophysics Data System (ADS)

Lang, N. P.; Covley, M. T.; Beltran, J.; Rogers, K.; Thomson, B. J.

2018-06-01

We are reporting on our year three status of mapping the V-49 quadrangle (Mahuea Tholus). Our mapping efforts over this past year emphasized the 13 impact craters in the quadrangle as well as larger-scale mapping of the Mahuea Tholus construct.

A Digital Tectonic Activity Map of the Earth

NASA Technical Reports Server (NTRS)

Lowman, Paul; Masuoka, Penny; Montgomery, Brian; OLeary, Jay; Salisbury, Demetra; Yates, Jacob

1999-01-01

The subject of neotectonics, covering the structures and structural activity of the last 5 million years (i.e., post-Miocene) is a well-recognized field, including "active tectonics," focussed on the last 500,000 years in a 1986 National Research Council report of that title. However, there is a cartographic gap between tectonic maps, generally showing all features regardless of age, and maps of current seismic or volcanic activity. We have compiled a map intended to bridge this gap, using modern data bases and computer-aided cartographic techniques. The maps presented here are conceptually descended from an earlier map showing tectonic and volcanic activity of the last one million years. Drawn by hand with the National Geographic Society's 1975 "The Physical World" map as a base, the 1981 map in various revisions has been widely reproduced in textbooks and various technical publications. However, two decades of progress call for a completely new map that can take advantage of new knowledge and cartographic techniques. The digital tectonic activity map (DTM), presented in shaded relief (Fig. 1) and schematic (Fig. 2) versions, is the result. The DTM is intended to show tectonism and volcanism of the last one million years, a period long enough to be representative of global activity, but short enough that features such as fault scarps and volcanos are still geomorphically recognizable. Data Sources and Cartographic Methods The DTM is based on a wide range of sources, summarized in Table 1. The most important is the digital elevation model, used to construct a shaded relief map. The bathymetry is largely from satellite altimetry, specifically the marine gravity compilations by Smith and Sandwell (1996). The shaded relief map was designed to match the new National Geographic Society world physical map (1992), although drawn independently, from the digital elevation model. The Robinson Projection is used instead of the earlier Van der Grinten one. Although neither conformal nor equal-area, the Robinson Projection provides a reasonable compromise and retains useful detail at high latitudes.

Abstracts of the Annual Meeting of Planetary Geologic Mappers, Flagstaff, AZ, 2008

NASA Technical Reports Server (NTRS)

Bleamaster, Leslie F., III (Editor); Tanaka, Kenneth L. (Editor); Kelley, Michael S. (Editor)

2008-01-01

Topics discussed include: Merging of the USGS Atlas of Mercury 1:5,000,000 Geologic Series; Geologic Mapping of the V-36 Thetis Regio Quadrangle: 2008 Progress Report; Structural Maps of the V-17 Beta Regio Quadrangle, Venus; Geologic Mapping of Isabella Quadrangle (V-50) and Helen Planitia, Venus; Renewed Mapping of the Nepthys Mons Quadrangle (V-54), Venus; Mapping the Sedna-Lavinia Region of Venus; Geologic Mapping of the Guinevere Planitia Quadrangle of Venus; Geological Mapping of Fortuna Tessera (V-2): Venus and Earth's Archean Process Comparisons; Geological Mapping of the North Polar Region of Venus (V-1 Snegurochka Planitia): Significant Problems and Comparisons to the Earth's Archean; Venus Quadrangle Geological Mapping: Use of Geoscience Data Visualization Systems in Mapping and Training; Geologic Map of the V-1 Snegurochka Planitia Quadrangle: Progress Report; The Fredegonde (V-57) Quadrangle, Venus: Characterization of the Venus Midlands; Formation and Evolution of Lakshmi Planum (V-7), Venus: Assessment of Models using Observations from Geological Mapping; Geologic Map of the Meskhent Tessera Quadrangle (V-3), Venus: Evidence for Early Formation and Preservation of Regional Topography; Geological Mapping of the Lada Terra (V-56) Quadrangle, Venus: A Progress Report; Geology of the Lachesis Tessera Quadrangle (V-18), Venus; Geologic Mapping of the Juno Chasma Quadrangle, Venus: Establishing the Relation Between Rifting and Volcanism; Geologic Mapping of V-19, V-28, and V-53; Lunar Geologic Mapping Program: 2008 Update; Geologic Mapping of the Marius Quadrangle, the Moon; Geologic Mapping along the Arabia Terra Dichotomy Boundary: Mawrth Vallis and Nili Fossae, Mars: Introductory Report; New Geologic Map of the Argyre Region of Mars; Geologic Evolution of the Martian Highlands: MTMs -20002, -20007, -25002, and -25007; Mapping Hesperia Planum, Mars; Geologic Mapping of the Meridiani Region, Mars; Geology of Holden Crater and the Holden and Ladon Multi-Ring Impact Basins, Margaritifer Terra, Mars; Geologic Mapping of Athabasca Valles; Geologic Mapping of MTM -30247, -35247 and -40247 Quadrangles, Reull Vallis Region of Mars; Geologic Mapping of the Martian Impact Crater Tooting; Geology of the Southern Utopia Planitia Highland-Lowland Boundary Plain: First Year Results and Second Year Plan; Mars Global Geologic Mapping: Amazonian Results; Recent Geologic Mapping Results for the Polar Regions of Mars; Geologic Mapping of the Medusae Fossae Formation on Mars (MC-8 SE and MC-23 NW) and the Northern Lowlands of Venus (V-16 and V-15); Geologic Mapping of the Zal, Hi'iaka, and Shamshu Regions of Io; Global Geologic Map of Europa; Material Units, Structures/Landforms, and Stratigraphy for the Global Geologic Map of Ganymede (1:15M); and Global Geologic Mapping of Io: Preliminary Results.

Power maps and wavefront for progressive addition lenses in eyeglass frames.

PubMed

Mejía, Yobani; Mora, David A; Díaz, Daniel E

2014-10-01

To evaluate a method for measuring the cylinder, sphere, and wavefront of progressive addition lenses (PALs) in eyeglass frames. We examine the contour maps of cylinder, sphere, and wavefront of a PAL assembled in an eyeglass frame using an optical system based on a Hartmann test. To reduce the data noise, particularly in the border of the eyeglass frame, we implement a method based on the Fourier analysis to extrapolate spots outside the eyeglass frame. The spots are extrapolated up to a circular pupil that circumscribes the eyeglass frame and compared with data obtained from a circular uncut PAL. By using the Fourier analysis to extrapolate spots outside the eyeglass frame, we can remove the edge artifacts of the PAL within its frame and implement the modal method to fit wavefront data with Zernike polynomials within a circular aperture that circumscribes the frame. The extrapolated modal maps from framed PALs accurately reflect maps obtained from uncut PALs and provide smoothed maps for the cylinder and sphere inside the eyeglass frame. The proposed method for extrapolating spots outside the eyeglass frame removes edge artifacts of the contour maps (wavefront, cylinder, and sphere), which may be useful to facilitate measurements such as the length and width of the progressive corridor for a PAL in its frame. The method can be applied to any shape of eyeglass frame.

A comparison of four different lens mappers.

PubMed

Larrue, Denis; Legeard, Morgane

2014-11-01

Recently, a number of lens mappers have become available for measuring the detailed optical properties of progressive addition lenses (PALs). The goal of this study was to compare the results obtained from several different lens mappers for a range of different lenses. The optical power maps of six lenses-two single-vision lenses, a parallel-sided slide, a flat prism, and two progressive lenses-were measured using four different lens mappers: the Dual Lens Mapper, the Nimo TR4005, the Rotlex Class Plus, and the Visionix VM2500. The repeatability of the instruments was also evaluated. All lens mappers gave very repeatable measurements; however, measurements among the lens mappers varied considerably. Differences appeared to be above the tolerance at the optical center for measurements of single-vision lenses, and these differences increase in the periphery up to 1.00 diopter. Similar differences were observed for the PALs, even increased by prism and base curve effect, with figures greater than 1 diopter in the periphery. The measurements made on the prism and lenses with different base curves suggest that base curve, thickness, and prismatic effect can all contribute to the differences among instruments. Measurements of a given lens taken with different lens mappers can vary substantially. Particular caution should be exercised when interpreting power maps for PALs taken with different instruments.

Antimicrobial (BN/PE) film combined with modified atmosphere packaging extends the shelf life of minimally processed fresh-cut iceberg lettuce.

PubMed

Kang, Sun-Chul; Kim, Min-Jeong; Park, In-Sik; Choi, Ung-Kyu

2008-03-01

This study was conducted to investigate the effect of modified atmosphere packaging (MAP) in combination with BN/PE film on the shelf life and quality of fresh-cut iceberg lettuce during cold storage. The total mesophilic population in the sample packed in BN/PE film under MAP conditions was dramatically reduced in comparison with that of PE film, PE film under MAP conditions, and BN/PE film. The O2 concentration in the BN/PE film under MAP conditions decreased slightly as the storage period progressed. The coloration of the iceberg lettuce progressed the slowest when it was packaged in BN/PE film under MAP conditions, followed by BN/PE film, PE film, and PE film under MAP conditions. The shelf life of fresh-cut iceberg lettuce packaged in the BN/PE film under MAP conditions was extended by more than 2 days at 10 degrees as compared with that of the BN/PE film in which the extension effect was more than 2 days longer than that of PE, PET, and OPP films.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willard, H.F.; Cremers, F.; Mandel, J.L.

A high-quality integrated genetic and physical map of the X chromosome from telomere to telomere, based primarily on YACs formatted with probes and STSs, is increasingly close to reality. At the Fifth International X Chromosome Workshop, organized by A.M. Poustka and D. Schlessinger in Heidelberg, Germany, April 24--27, 1994, substantial progress was recorded on extension and refinement of the physical map, on the integration of genetic and cytogenetic data, on attempts to use the map to direct gene searches, and on nascent large-scale sequencing efforts. This report summarizes physical and genetic mapping information presented at the workshop and/or published sincemore » the reports of the fourth International X Chromosome Workshop. The principle aim of the workshop was to derive a consensus map of the chromosome, in terms of physical contigs emphasizing the location of genes and microsatellite markers. The resulting map is presented and updates previous versions. This report also updates the list of highly informative microsatellites. The text highlights the working state of the map, the genes known to reside on the X, and the progress toward integration of various types of data.« less

Loess Thickness Variations Across the Loess Plateau of China

NASA Astrophysics Data System (ADS)

Zhu, Yuanjun; Jia, Xiaoxu; Shao, Mingan

2018-07-01

The soil thickness is very important for investigating and modeling soil-water processes, especially on the Loess Plateau of China with its deep loess deposit and limited water resources. A digital elevation map (DEM) of the Loess Plateau and neighborhood analysis in ArcGIS software were used to generate a map of loess thickness, which was then validated by 162 observations across the plateau. The generated loess thickness map has a high resolution of 100 m × 100 m. The map indicates that loess is thick in the central part of the plateau and becomes gradually shallower in the southeast and northwest directions. The areas near mountains and river basins have the shallowest loess deposit. The mean loess thickness is the deepest in the zones with 400-600-mm precipitation and decreases gradually as precipitation varies beyond this range. Our validation indicates that the map just slightly overestimates loess thickness and is reliable. The loess thickness is mostly between 0 and 350 m in the Loess Plateau region. The calculated mean loess thickness is 105.7 m, with the calibrated value being 92.2 m over the plateau exclusive of the mountain areas. Our findings provide very basic data of loess thickness and demonstrate great progress in mapping the loess thickness distribution for the plateau, which are valuable for a better study of soil-water processes and for more accurate estimations of soil water, carbon, and solute reservoirs in the Loess Plateau of China.

Loess Thickness Variations Across the Loess Plateau of China

NASA Astrophysics Data System (ADS)

Zhu, Yuanjun; Jia, Xiaoxu; Shao, Mingan

2018-01-01

The soil thickness is very important for investigating and modeling soil-water processes, especially on the Loess Plateau of China with its deep loess deposit and limited water resources. A digital elevation map (DEM) of the Loess Plateau and neighborhood analysis in ArcGIS software were used to generate a map of loess thickness, which was then validated by 162 observations across the plateau. The generated loess thickness map has a high resolution of 100 m × 100 m. The map indicates that loess is thick in the central part of the plateau and becomes gradually shallower in the southeast and northwest directions. The areas near mountains and river basins have the shallowest loess deposit. The mean loess thickness is the deepest in the zones with 400-600-mm precipitation and decreases gradually as precipitation varies beyond this range. Our validation indicates that the map just slightly overestimates loess thickness and is reliable. The loess thickness is mostly between 0 and 350 m in the Loess Plateau region. The calculated mean loess thickness is 105.7 m, with the calibrated value being 92.2 m over the plateau exclusive of the mountain areas. Our findings provide very basic data of loess thickness and demonstrate great progress in mapping the loess thickness distribution for the plateau, which are valuable for a better study of soil-water processes and for more accurate estimations of soil water, carbon, and solute reservoirs in the Loess Plateau of China.

Sampling strategies to improve passive optical remote sensing of river bathymetry

USGS Publications Warehouse

Legleiter, Carl; Overstreet, Brandon; Kinzel, Paul J.

2018-01-01

Passive optical remote sensing of river bathymetry involves establishing a relation between depth and reflectance that can be applied throughout an image to produce a depth map. Building upon the Optimal Band Ratio Analysis (OBRA) framework, we introduce sampling strategies for constructing calibration data sets that lead to strong relationships between an image-derived quantity and depth across a range of depths. Progressively excluding observations that exceed a series of cutoff depths from the calibration process improved the accuracy of depth estimates and allowed the maximum detectable depth ($d_{max}$) to be inferred directly from an image. Depth retrieval in two distinct rivers also was enhanced by a stratified version of OBRA that partitions field measurements into a series of depth bins to avoid biases associated with under-representation of shallow areas in typical field data sets. In the shallower, clearer of the two rivers, including the deepest field observations in the calibration data set did not compromise depth retrieval accuracy, suggesting that $d_{max}$ was not exceeded and the reach could be mapped without gaps. Conversely, in the deeper and more turbid stream, progressive truncation of input depths yielded a plausible estimate of $d_{max}$ consistent with theoretical calculations based on field measurements of light attenuation by the water column. This result implied that the entire channel, including pools, could not be mapped remotely. However, truncation improved the accuracy of depth estimates in areas shallower than $d_{max}$, which comprise the majority of the channel and are of primary interest for many habitat-oriented applications.

A 405-kb cosmid contig and HindIII restriction map of the progressive myoclonus epilepsy type 1 (EPM1) candidate region in 21q22.3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lafreniere, R.G.; Rouleau, G.A.; De Jong, P.J.

1995-09-01

As a step toward identifying the molecular defect in patients afflicted with progressive myoclonus epilepsy type 1 (EPM1), we have assembled a cosmid contig of the candidate EPM1 region in 21q22.3. The contig constitutes a collection of 87 different cosmids spanning 405 kb based on a derived HindIII restriction map. Potential CpG-rich islands have been identified based on the restriction map generated from eight different rare-cutting enzymes. This contig contains the genetic material required for the isolation of expressed sequences and the identification of the gene defective in EPM1 and possibly other disorders mapping to this region. 15 refs., 1more » fig.« less

Mapping of stripe rust resistance QTL in Cappelle-Desprez × PBW343 RIL population effective in northern wheat belt of India.

PubMed

Pawar, Sushma Kumari; Sharma, Davinder; Duhan, Joginder Singh; Saharan, Mahender Singh; Tiwari, Ratan; Sharma, Indu

2016-06-01

Stripe rust caused by Puccinia striiformis f. sp. tritici is most important and devastating disease of wheat worldwide, which affects the grain yields, quality and nutrition. To elucidate, the genetic basis of resistance, a mapping population of recombinant inbred lines was developed from a cross between resistant Cappelle-Desprez and susceptible cultivar PBW343 using single-seed descent. Variety PBW343 had been one of the most popular cultivars of North Western Plains Zone, for more than a decade, before succumbing to the stripe rust. Cappelle-Desprez, a source of durable adult plant resistance, has maintained its resistance against stripe rust for a long time in Europe. Map construction and QTL analysis were completed with 1012 polymorphic (DArT and SSR) markers. Screenings for stripe rust disease were carried out in field condition for two consecutive crop seasons (2012-2013 and 2013-2014). Susceptible parent (PBW343) achieved a significant level of disease i.e., 100 % in both the years. In present investigations, resistance in Cappelle-Desprez was found stable and response to the rust ranged from 0 to 1.5 % over the years. The estimated broad-sense heritability (h 2 ) of stripe rust rAUDPC in the mapping population was 0.82. The relative area under the disease progress curve data showed continuous distributions, indicating that trait was controlled multigenically. Genomic region identified on chromosome 2D, was located within the short arm, with flanking markers (Xgwm484-Xcfd73), explained phenotypic variation (PVE) ranged from 13.9 to 31.8 %. The genomic region identified on chromosome 5B was found with the effect of maximum contribution with flanking DArT markers (1376633|F|0-1207571|F|0), PVE ranged from 24 to 27.0 %. This can, therefore, be utilized for marker assisted selection in developing much needed stripe rust resistant lines for the northern wheat belt of India.

Global mapping of infectious disease

PubMed Central

Hay, Simon I.; Battle, Katherine E.; Pigott, David M.; Smith, David L.; Moyes, Catherine L.; Bhatt, Samir; Brownstein, John S.; Collier, Nigel; Myers, Monica F.; George, Dylan B.; Gething, Peter W.

2013-01-01

The primary aim of this review was to evaluate the state of knowledge of the geographical distribution of all infectious diseases of clinical significance to humans. A systematic review was conducted to enumerate cartographic progress, with respect to the data available for mapping and the methods currently applied. The results helped define the minimum information requirements for mapping infectious disease occurrence, and a quantitative framework for assessing the mapping opportunities for all infectious diseases. This revealed that of 355 infectious diseases identified, 174 (49%) have a strong rationale for mapping and of these only 7 (4%) had been comprehensively mapped. A variety of ambitions, such as the quantification of the global burden of infectious disease, international biosurveillance, assessing the likelihood of infectious disease outbreaks and exploring the propensity for infectious disease evolution and emergence, are limited by these omissions. An overview of the factors hindering progress in disease cartography is provided. It is argued that rapid improvement in the landscape of infectious diseases mapping can be made by embracing non-conventional data sources, automation of geo-positioning and mapping procedures enabled by machine learning and information technology, respectively, in addition to harnessing labour of the volunteer ‘cognitive surplus’ through crowdsourcing. PMID:23382431

Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

NASA Astrophysics Data System (ADS)

Park, Yongkeun; Diez-Silva, Monica; Fu, Dan; Popescu, Gabriel; Choi, Wonshik; Barman, Ishan; Suresh, Subra; Feld, Michael S.

2010-03-01

We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.

Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease.

PubMed

Kang, Ju-Hee; Vanderstichele, Hugo; Trojanowski, John Q; Shaw, Leslie M

2012-04-01

The xMAP-Luminex multiplex platform for measurement of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers using Innogenetics AlzBio3 immunoassay reagents that are for research use only has been shown to be an effective tool for early detection of an AD-like biomarker signature based on concentrations of CSF Aβ(1-42), t-tau and p-tau(181). Among the several advantages of the xMAP-Luminex platform for AD CSF biomarkers are: a wide dynamic range of ready-to-use calibrators, time savings for the simultaneous analyses of three biomarkers in one analytical run, reduction of human error, potential of reduced cost of reagents, and a modest reduction of sample volume as compared to conventional enzyme-linked immunosorbant assay (ELISA) methodology. Recent clinical studies support the use of CSF Aβ(1-42), t-tau and p-tau(181) measurement using the xMAP-Luminex platform for the early detection of AD pathology in cognitively normal individuals, and for prediction of progression to AD dementia in subjects with mild cognitive impairment (MCI). Studies that have shown the prediction of risk for progression to AD dementia by MCI patients provide the basis for the use of CSF Aβ(1-42), t-tau and p-tau(181) testing to assign risk for progression in patients enrolled in therapeutic trials. Furthermore emerging study data suggest that these pathologic changes occur in cognitively normal subjects 20 or more years before the onset of clinically detectable memory changes thus providing an objective measurement for use in the assessment of treatment effects in primary treatment trials. However, numerous previous ELISA and Luminex-based multiplex studies reported a wide range of absolute values of CSF Aβ(1-42), t-tau and p-tau(181) indicative of substantial inter-laboratory variability as well as varying degrees of intra-laboratory imprecision. In order to address these issues a recent inter-laboratory investigation that included a common set of CSF pool aliquots from controls as well as AD patients over a range of normal and pathological Aβ(1-42), t-tau and p-tau(181) values as well as agreed-on standard operating procedures (SOPs) assessed the reproducibility of the multiplex methodology and Innogenetics AlzBio3 immunoassay reagents. This study showed within-center precision values of 5% to a little more than 10% and good inter-laboratory %CV values (10-20%). There are several likely factors influencing the variability of CSF Aβ(1-42), t-tau and p-tau(181) measurements. In this review, we describe the pre-analytical, analytical and post-analytical sources of variability including sources inherent to kits, and describe procedures to decrease the variability. A CSF AD biomarker Quality Control program has been established and funded by the Alzheimer Association, and global efforts are underway to further define optimal pre-analytical SOPs and best practices for the methodologies available or in development including plans for production of a standard reference material that could provide for a common standard against which manufacturers of immunoassay kits would assign calibration standard values. Copyright © 2012 Elsevier Inc. All rights reserved.

Geologic maps of the eastern Alaska Range, Alaska (1:63,360 scale)

USGS Publications Warehouse

Nokleberg, Warren J.; Aleinikoff, John N.; Bond, Gerard C.; Ferrians, Oscar J.; Herzon, Paige L.; Lange, Ian M.; Miyaoka, Ronny T.; Richter, Donald H.; Schwab, Carl E.; Silva, Steven R.; Smith, Thomas E.; Zehner, Richard E.

2015-01-01

This report provides a description of map units for a suite of 44 inch-to-mile (1:63,360-scale) geologic quadrangle maps of the eastern Alaska Range. This report also contains a geologic and tectonic summary and a comprehensive list of references pertaining to geologic mapping and specialized studies of the region. In addition to the geologic maps of the eastern Alaska Range, this package includes a list of map units and an explanation of map symbols and abbreviations. The geologic maps display detailed surficial and bedrock geology, structural and stratigraphic data, portrayal of the active Denali fault that bisects the core of the east–west-trending range, and portrayal of other young faults along the north and south flanks of the range.

Efficient Swath Mapping Laser Altimetry Demonstration Instrument Incubator Program

NASA Technical Reports Server (NTRS)

Yu, Anthony W.; Krainak, Michael A,; Harding, David J.; Abshire, James B.; Sun, Xiaoli; Cavanaugh, John; Valett, Susan

2010-01-01

In this paper we will discuss our eighteen-month progress of a three-year Instrument Incubator Program (IIP) funded by NASA Earth Science Technology Office (ESTO) on swath mapping laser altimetry system. This paper will discuss the system approach, enabling technologies and instrument concept for the swath mapping laser altimetry.

Concept Mapping for Critical Thinking: Efficacy, Timing, & Type

ERIC Educational Resources Information Center

Harris, Charles M.; Zha, Shenghua

2017-01-01

Many college students are not progressing in the development of their critical thinking skills. Concept mapping is a technique for facilitating validation of one's critical thinking by graphically depicting the structure of complex concepts. Each of our three studies of concept mapping involved approximately 240 students enrolled in four sections…

Fourth international circumpolar arctic vegetation mapping workshop

USGS Publications Warehouse

Raynolds, Martha K.; Markon, C.J.

2002-01-01

During the week of April 10, 2001, the Fourth International Circumpolar Arctic Vegetation Mapping Workshop was held in Moscow, Russia. The purpose of this meeting was to bring together the vegetation scientists working on the Circumpolar Arctic Vegetation Map (CAVM) to (1) review the progress of current mapping activities, (2) discuss and agree upon a standard set of arctic tundra subzones, (3) plan for the production and dissemination of a draft map, and (4) begin work on a legend for the final map.

Geologic map of the northern White Hills, Mohave County, Arizona

USGS Publications Warehouse

Howard, Keith A.; Priest, Susan S.; Lundstrom, Scott C.; Block, Debra L.

2017-07-10

IntroductionThe northern White Hills map area lies within the Kingman Uplift, a regional structural high in which Tertiary rocks lie directly on Proterozoic rocks as a result of Cretaceous orogenic uplift and erosional stripping of Paleozoic and Mesozoic strata. The Miocene Salt Spring Fault forms the major structural boundary in the map area. This low-angle normal fault separates a footwall (lower plate) of Proterozoic gneisses on the east and south from a hanging wall (upper plate) of faulted middle Miocene volcanic and sedimentary rocks and their Proterozoic substrate. The fault is part of the South Virgin–White Hills Detachment Fault, which records significant tectonic extension that decreases from north to south. Along most of its trace, the Salt Spring Fault dips gently westward, but it also has north-dipping segments along salients. A dissected, domelike landscape on the eroded footwall, which contains antiformal salients and synformal reentrants, extends through the map area from Salt Spring Bay southward to the Golden Rule Peak area. The “Lost Basin Range” represents an upthrown block of the footwall, raised on the steeper Lost Basin Range Fault.The Salt Spring Fault, as well as the normal faults that segment its hanging wall, deform rocks that are about 16 to 10 Ma, and younger deposits overlie the faults. Rhyodacitic welded tuff about 15 Ma underlies a succession of geochemically intermediate to progressively more mafic lavas (including alkali basalt) that range from about 14.7 to 8 Ma, interfingered with sedimentary rocks and breccias in the western part of the map area. Upper Miocene strata record further filling of the extension-formed continental basins. Basins that are still present in the modern landscape reflect the youngest stages of extensional-basin formation, expressed as the downfaulted Detrital Valley and Hualapai Wash basins in the western and eastern parts of the map area, respectively, as well as the north-centrally located, northward-sagged Temple Basin. Pliocene fluvial and piedmont alluvial fan deposits record postextensional basin incision, refilling, and reincision driven by the inception and evolution of the westward-flowing Colorado River, centered north of the map area.

Mapping urban land cover from space: Some observations for future progress

NASA Technical Reports Server (NTRS)

Gaydos, L.

1982-01-01

The multilevel classification system adopted by the USGS for operational mapping of land use and land cover at levels 1 and 2 is discussed and the successes and failures of mapping land cover from LANDSAT digital data are reviewed. Techniques used for image interpretation and their relationships to sensor parameters are examined. The requirements for mapping levels 2 and 3 classes are considered.

Field determination of optimal dates for the discrimination of invasive wetland plant species using derivative spectral analysis

USGS Publications Warehouse

Laba, M.; Tsai, F.; Ogurcak, D.; Smith, S.; Richmond, M.E.

2005-01-01

Mapping invasive plant species in aquatic and terrestrial ecosystems helps to understand the causes of their progression, manage some of their negative consequences, and control them. In recent years, a variety of new remote-sensing techniques, like Derivative Spectral Analysis (DSA) of hyperspectral data, have been developed to facilitate this mapping. A number of questions related to these techniques remain to be addressed. This article attempts to answer one of these questions: Is the application of DSA optimal at certain times of the year? Field radiometric data gathered weekly during the summer of 1999 at selected field sites in upstate New York, populated with purple loosestrife (Lythrum salicaria L.), common reed (Phragmites australis (Cav.)) and cattail (Typha L.) are analyzed using DSA to differentiate among plant community types. First, second and higher-order derivatives of the reflectance spectra of nine field plots, varying in plant composition, are calculated and analyzed in detail to identify spectral ranges in which one or more community types have distinguishing features. On the basis of the occurrence and extent of these spectral ranges, experimental observations suggest that a satisfactory differentiation among community types was feasible on 30 August, when plants experienced characteristic phenological changes (transition from flowers to seed heads). Generally, dates in August appear optimal from the point of view of species differentiability and could be selected for image acquisitions. This observation, as well as the methodology adopted in this article, should provide a firm basis for the acquisition of hyperspectral imagery and for mapping the targeted species over a broad range of spatial scales. ?? 2005 American Society for Photogrammetry and Remote Sensing.

Long-Term Evolution of the Electrical Stimulation Levels for Cochlear Implant Patients

PubMed Central

Vargas, Jose Luis; Sainz, Manuel; Roldan, Cristina; de la Torre, Angel

2012-01-01

Objectives The stimulation levels programmed in cochlear implant systems are affected by an evolution since the first switch-on of the processor. This study was designed to evaluate the changes in stimulation levels over time and the relationship between post-implantation physiological changes and with the hearing experience provided by the continuous use of the cochlear implant. Methods Sixty-two patients, ranging in age from 4 to 68 years at the moment of implantation participated in this study. All subjects were implanted with the 12 channels COMBI 40+ cochlear implant at San Cecilio University Hospital, Granada, Spain. Hearing loss etiology and progression characteristics varied across subjects. Results The analyzed programming maps show that the stimulation levels suffer a fast evolution during the first weeks after the first switch-on of the processor. Then, the evolution becomes slower and the programming parameters tend to be stable at about 6 months after the first switch-on. The evolution of the stimulation levels implies an increment of the electrical dynamic range, which is increased from 15.4 to 20.7 dB and improves the intensity resolution. A significant increment of the sensitivity to acoustic stimuli is also observed. For some patients, we have also observed transitory changes in the electrode impedances associated to secretory otitis media, which cause important changes in the programming maps. Conclusion We have studied the long-term evolution of the stimulation levels in cochlear implant patients. Our results show the importance of systematic measurements of the electrode impedances before the revision of the programming map. This report also highlights that the evolution of the programming maps is an important factor to be considered in order to determine an adequate calendar fitting of the cochlear implant processor. PMID:23205223

The fractured landscape of RNA-seq alignment: the default in our STARs.

PubMed

Ballouz, Sara; Dobin, Alexander; Gingeras, Thomas R; Gillis, Jesse

2018-06-01

Many tools are available for RNA-seq alignment and expression quantification, with comparative value being hard to establish. Benchmarking assessments often highlight methods' good performance, but are focused on either model data or fail to explain variation in performance. This leaves us to ask, what is the most meaningful way to assess different alignment choices? And importantly, where is there room for progress? In this work, we explore the answers to these two questions by performing an exhaustive assessment of the STAR aligner. We assess STAR's performance across a range of alignment parameters using common metrics, and then on biologically focused tasks. We find technical metrics such as fraction mapping or expression profile correlation to be uninformative, capturing properties unlikely to have any role in biological discovery. Surprisingly, we find that changes in alignment parameters within a wide range have little impact on both technical and biological performance. Yet, when performance finally does break, it happens in difficult regions, such as X-Y paralogs and MHC genes. We believe improved reporting by developers will help establish where results are likely to be robust or fragile, providing a better baseline to establish where methodological progress can still occur.

78 FR 53712 - Surface Transportation Project Delivery Program Application Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... the 21st Century Act (MAP-21), which converted the Surface Transportation Project Delivery Pilot... signed into law the Moving Ahead for Progress in the 21st Century Act (MAP-21), Public Law 112-141, 126... days from the date of MAP-21's enactment (October 1, 2012)--the regulations concerning the information...

78 FR 30258 - Hazardous Materials: Enhanced Enforcement Procedures-Resumption of Transportation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... 21st Century Act, or the MAP-21, which included the Hazardous Materials Transportation Safety... 6, 2012, the President signed the Moving Ahead for Progress in the 21st Century Act, or the MAP-21... This NPRM In MAP-21 Congress directed the Secretary to address certain transportation matters related...

Methods of Technological Forecasting,

DTIC Science & Technology

1977-05-01

Trend Extrapolation Progress Curve Analogy Trend Correlation Substitution Analysis or Substitution Growth Curves Envelope Curve Advances in the State of...the Art Technological Mapping Contextual Mapping Matrix Input-Output Analysis Mathematical Models Simulation Models Dynamic Modelling. CHAPTER IV...Generation Interaction between Needs and Possibilities Map of the Technological Future — (‘ross- Impact Matri x Discovery Matrix Morphological Analysis

An assessment of the safety performance of farm vehicles subject to exemptions under MAP-21 : analysis brief.

DOT National Transportation Integrated Search

2016-05-01

The Moving Ahead for Progress in the 21st Century Act (MAP-21) requires that the Secretary of Transportation conduct a Safety Study of covered farm vehicles. The Act defines a covered farm vehicle as a vehicle that: MAP-21 requires that t...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardiner, K.

Tremendous progress has been made in the construction of physical and genetic maps of the human chromosomes. The next step in the solving of disease related problems, and in understanding the human genome as a whole, is the systematic isolation of transcribed sequences. Many investigators have already embarked upon comprehensive gene searches, and many more are considering the best strategies for undertaking such searches. Because these are likely to be costly and time consuming endeavors, it is important to determine the most efficient approaches. As a result, it is critical that investigators involved in the construction of transcriptional maps havemore » the opportunity to discuss their experiences and their successes with both old and new technologies. This document contains the proceedings of the Fourth Annual Workshop on the Identification of Transcribed Sequences, held in Montreal, Quebec, October 16-18, 1994. Included are the workshop notebook, containing the agenda, abstracts presented and list of attendees. Topics included: Progress in the application of the hybridization based approaches and exon trapping; Progress in transcriptional map construction of selected genomic regions; Computer assisted analysis of genomic and protein coding sequences and additional new approaches; and, Sequencing and mapping of random cDNAs.« less

Plenary: Progress in Regional Landslide Hazard Assessment—Examples from the USA

USGS Publications Warehouse

Baum, Rex L.; Schulz, William; Brien, Dianne L.; Burns, William J.; Reid, Mark E.; Godt, Jonathan W.

2014-01-01

Landslide hazard assessment at local and regional scales contributes to mitigation of landslides in developing and densely populated areas by providing information for (1) land development and redevelopment plans and regulations, (2) emergency preparedness plans, and (3) economic analysis to (a) set priorities for engineered mitigation projects and (b) define areas of similar levels of hazard for insurance purposes. US Geological Survey (USGS) research on landslide hazard assessment has explored a range of methods that can be used to estimate temporal and spatial landslide potential and probability for various scales and purposes. Cases taken primarily from our work in the U.S. Pacific Northwest illustrate and compare a sampling of methods, approaches, and progress. For example, landform mapping using high-resolution topographic data resulted in identification of about four times more landslides in Seattle, Washington, than previous efforts using aerial photography. Susceptibility classes based on the landforms captured 93 % of all historical landslides (all types) throughout the city. A deterministic model for rainfall infiltration and shallow landslide initiation, TRIGRS, was able to identify locations of 92 % of historical shallow landslides in southwest Seattle. The potentially unstable areas identified by TRIGRS occupied only 26 % of the slope areas steeper than 20°. Addition of an unsaturated infiltration model to TRIGRS expands the applicability of the model to areas of highly permeable soils. Replacement of the single cell, 1D factor of safety with a simple 3D method of columns improves accuracy of factor of safety predictions for both saturated and unsaturated infiltration models. A 3D deterministic model for large, deep landslides, SCOOPS, combined with a three-dimensional model for groundwater flow, successfully predicted instability in steep areas of permeable outwash sand and topographic reentrants. These locations are consistent with locations of large, deep, historically active landslides. For an area in Seattle, a composite of the three maps illustrates how maps produced by different approaches might be combined to assess overall landslide potential. Examples from Oregon, USA, illustrate how landform mapping and deterministic analysis for shallow landslide potential have been adapted into standardized methods for efficiently producing detailed landslide inventory and shallow landslide susceptibility maps that have consistent content and format statewide.

Mars Global Geologic Mapping Progress and Suggested Geographic-Based Hierarchal Systems for Unit Grouping and Naming

NASA Technical Reports Server (NTRS)

Tanaka, K. L.; Dohm, J. M.; Irwin, R.; Kolb, E. J.; Skinner, J. A., Jr.; Hare, T. M.

2010-01-01

We are in the fourth year of a fiveyear effort to map the global geology of Mars at 1:20M scale using mainly Mars Global Surveyor, Mars Express, and Mars Odyssey image and altimetry datasets. Previously, we reported on details of project management, mapping datasets (local and regional), initial and anticipated mapping approaches, and tactics of map unit delineation and description [1-2]. Last year, we described mapping and unit delineation results thus far, a new unit identified in the northern plains, and remaining steps to complete the map [3].

Recent Progress in Entry Radiation Measurements in the NASA Ames Electric ARC Shock Tube Facility

NASA Technical Reports Server (NTRS)

Cruden, Brett A.

2012-01-01

The Electric Arc Shock Tube (EAST) at NASA Ames Research Center is NASA's only working shock tube capable of obtaining conditions representative of entry in a multitude of planetary atmospheres. The facility is capable of mapping spectroscopic signatures of a wide range of planetary entries from the Vacuum Ultraviolet through Mid-Wave Infrared (120-5500 nm). This paper summarizes the tests performed in EAST for Earth, Mars and Venus entries since 2008, then focuses on a specific test case for CO2/N2 mixtures. In particular, the paper will focus on providing information for the proper interpretation of the EAST data.

Long-term comparison of Kuparuk Watershed active layer maps, northern Alaska, USA

NASA Astrophysics Data System (ADS)

Nyland, K. E.; Queen, C.; Nelson, F. E.; Shiklomanov, N. I.; Streletskiy, D. A.; Klene, A. E.

2017-12-01

The active layer, or the uppermost soil horizon that thaws seasonally, is among the most dynamic components of the permafrost system. Evaluation of the thickness and spatial variation of the active layer is critical to many components of Arctic research, including climatology, ecology, environmental monitoring, and engineering. In this study we mapped active-layer thickness (ALT) across the 22,278 sq. km Kuparuk River basin on Alaska's North Slope throughout the summer of 2016. The Kuparuk River extends from the Brooks Range through the Arctic Foothills and across the Arctic Coastal Plain physiographic provinces, and drains into the Beaufort Sea. Methodology followed procedures used to produce an ALT map of the basin in 1995 accounting for the effects of topography, vegetation, topoclimate, and soils, using the same spatial sampling scheme for direct ALT and temperature measurement at representative locations and relating these parameters to vegetation-soil associations. A simple semi-empirical engineering solution was used to estimate thaw rates for the different associations. An improved lapse-rate formulation and a higher-resolution DEM were used to relate temperature to elevation. Three ALT maps were generated for the 2016 summer, combining measured thaw depth, temperature records, the 25 m ArcticDEM, high resolution remote sensed data, empirical laps rates, and a topoclimatic index through the thaw solution. These maps were used to track the spatial progression of thaw through the 2016 summer season and estimate a total volume of thawed soil. Maps produced in this study were compared to the 1995 map to track areas of significant geographic changes in patterns of ALT and total volume of thawed soil.

Addressing MAP-21 freight objectives using GPS data.

DOT National Transportation Integrated Search

2016-12-01

Freight planning and operation perspectives of Moving Ahead for Progress in the 21st Century Act (MAP-21) includes development of a national freight plan to address freight congestion bottlenecks, connectivity enhancement of major intermodal centers,...

Measuring Progressions: Assessment Structures Underlying a Learning Progression

ERIC Educational Resources Information Center

Wilson, Mark

2009-01-01

This article describes some of the underlying conceptualizations that have gone into the work of the BEAR Center in the development of learning progressions. The core of all of these developments has been the construct map, which is the first building block in the BEAR Assessment System (BAS). After introducing the concept of a learning…

Progressive simplification and transmission of building polygons based on triangle meshes

NASA Astrophysics Data System (ADS)

Li, Hongsheng; Wang, Yingjie; Guo, Qingsheng; Han, Jiafu

2010-11-01

Digital earth is a virtual representation of our planet and a data integration platform which aims at harnessing multisource, multi-resolution, multi-format spatial data. This paper introduces a research framework integrating progressive cartographic generalization and transmission of vector data. The progressive cartographic generalization provides multiple resolution data from coarse to fine as key scales and increments between them which is not available in traditional generalization framework. Based on the progressive simplification algorithm, the building polygons are triangulated into meshes and encoded according to the simplification sequence of two basic operations, edge collapse and vertex split. The map data at key scales and encoded increments between them are stored in a multi-resolution file. As the client submits requests to the server, the coarsest map is transmitted first and then the increments. After data decoding and mesh refinement the building polygons with more details will be visualized. Progressive generalization and transmission of building polygons is demonstrated in the paper.

Mapping a Teacher Boycott in Seattle

ERIC Educational Resources Information Center

Zeichner, Noah

2013-01-01

The author, a teacher in the Seattle public schools, tells the story of a movement begun by teachers at Garfield High School who in January 2013 voted unanimously to refuse to administer the Measures of Academic Progress (MAP) test. The MAP boycott spread to seven more Seattle schools, and teachers at 10 more schools signed statements of support.…

Geothermal Energy Resources of Navy/Marine Corps Installations on the Atlantic and Gulf Coastal Plain.

DTIC Science & Technology

1980-03-01

Geological Survey ( AAPG -USGS) thermal gradient map of North America, at a scale of 1:5,000,000, gives the hypothesized average depth (by contours) in...file reports; USGS topographic and geologic maps; AAPG -USGS special geologic maps; APL/JHU reports; VPI-SU progress re- ports to DOE/DGE; technical

Improving Critical Thinking Using Web Based Argument Mapping Exercises with Automated Feedback

ERIC Educational Resources Information Center

Butchart, Sam; Forster, Daniella; Gold, Ian; Bigelow, John; Korb, Kevin; Oppy, Graham; Serrenti, Alexandra

2009-01-01

In this paper we describe a simple software system that allows students to practise their critical thinking skills by constructing argument maps of natural language arguments. As the students construct their maps of an argument, the system provides automatic, real time feedback on their progress. We outline the background and theoretical framework…

EcoEvo-MAPS: An Ecology and Evolution Assessment for Introductory through Advanced Undergraduates

ERIC Educational Resources Information Center

Summers, Mindi M.; Couch, Brian A.; Knight, Jennifer K.; Brownell, Sara E.; Crowe, Alison J.; Semsar, Katharine; Wright, Christian D.; Smith, Michelle K.

2018-01-01

A new assessment tool, Ecology and Evolution--Measuring Achievement and Progression in Science or EcoEvo-MAPS, measures student thinking in ecology and evolution during an undergraduate course of study. EcoEvo-MAPS targets foundational concepts in ecology and evolution and uses a novel approach that asks students to evaluate a series of…

Estimating and mapping the incidence of dengue and chikungunya in Honduras during 2015 using Geographic Information Systems (GIS).

PubMed

Zambrano, Lysien I; Sierra, Manuel; Lara, Bredy; Rodríguez-Núñez, Iván; Medina, Marco T; Lozada-Riascos, Carlos O; Rodríguez-Morales, Alfonso J

Geographical information systems (GIS) use for development of epidemiological maps in dengue has been extensively used, however not in other emerging arboviral diseases, nor in Central America. Surveillance cases data (2015) were used to estimate annual incidence rates of dengue and chikungunya (cases/100,000 pop) to develop the first maps in the departments and municipalities of Honduras. The GIS software used was Kosmo Desktop 3.0RC1 ® . Four thematic maps were developed according departments, municipalities, diseases incidence rates. A total of 19,289 cases of dengue and 85,386 of chikungunya were reported (median, 726 cases/week for dengue and 1460 for chikungunya). Highest peaks were observed at weeks 25th and 27th, respectively. There was association between progression by weeks (p<0.0001). The cumulated crude national rate was estimated in 224.9 cases/100,000 pop for dengue and 995.6 for chikungunya. The incidence rates ratio between chikungunya and dengue is 4.42 (ranging in municipalities from 0.0 up to 893.0 [San Vicente Centenario]). Burden of both arboviral diseases is concentrated in capital Central District (>37%, both). Use of GIS-based epidemiological maps allow to guide decisions-taking for prevention and control of diseases that still represents significant issues in the region and the country, but also in emerging conditions. Copyright © 2016 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

Estimating Earthquake Magnitude from the Kentucky Bend Scarp in the New Madrid Seismic Zone Using Field Geomorphic Mapping and High-Resolution LiDAR Topography

NASA Astrophysics Data System (ADS)

Kelson, K. I.; Kirkendall, W. G.

2014-12-01

Recent suggestions that the 1811-1812 earthquakes in the New Madrid Seismic Zone (NMSZ) ranged from M6.8-7.0 versus M8.0 have implications for seismic hazard estimation in the central US. We more accurately identify the location of the NW-striking, NE-facing Kentucky Bend scarp along the northern Reelfoot fault, which is spatially associated with the Lake County uplift, contemporary seismicity, and changes in the Mississippi River from the February 1812 earthquake. We use 1m-resolution LiDAR hillshades and slope surfaces, aerial photography, soil surveys, and field geomorphic mapping to estimate the location, pattern, and amount of late Holocene coseismic surface deformation. We define eight late Holocene to historic fluvial deposits, and delineate younger alluvia that are progressively inset into older deposits on the upthrown, western side of the fault. Some younger, clayey deposits indicate past ponding against the scarp, perhaps following surface deformational events. The Reelfoot fault is represented by sinuous breaks-in-slope cutting across these fluvial deposits, locally coinciding with shallow faults identified via seismic reflection data (Woolery et al., 1999). The deformation pattern is consistent with NE-directed reverse faulting along single or multiple SW-dipping fault planes, and the complex pattern of fluvial deposition appears partially controlled by intermittent uplift. Six localities contain scarps across correlative deposits and allow evaluation of cumulative surface deformation from LiDAR-derived topographic profiles. Displacements range from 3.4±0.2 m, to 2.2±0.2 m, 1.4±0.3 m, and 0.6±0.1 m across four progressively younger surfaces. The spatial distribution of the profiles argues against the differences being a result of along-strike uplift variability. We attribute the lesser displacements of progressively younger deposits to recurrent surface deformation, but do not yet interpret these initial data with respect to possible earthquake magnitudes. Additional efforts hopefully will address shallow subsurface evidence of single- or multiple-deformational events at selected localities.

The Reference Elevation Model of Antarctica (REMA): A High Resolution, Time-Stamped Digital Elevation Model for the Antarctic Ice Sheet

NASA Astrophysics Data System (ADS)

Howat, I.; Noh, M. J.; Porter, C. C.; Smith, B. E.; Morin, P. J.

2017-12-01

We are creating the Reference Elevation Model of Antarctica (REMA), a continuous, high resolution (2-8 m), high precision (accuracy better than 1 m) reference surface for a wide range of glaciological and geodetic applications. REMA will be constructed from stereo-photogrammetric Digital Surface Models (DSM) extracted from pairs of submeter resolution DigitalGlobe satellite imagery and vertically registred to precise elevations from near-coincident airborne LiDAR, ground-based GPS surveys and Cryosat-2 radar altimetry. Both a seamless mosaic and individual, time-stamped DSM strips, collected primarily between 2012 and 2016, will be distributed to enable change measurement. These data will be used for mapping bed topography from ice thickness, measuring ice thickness changes, constraining ice flow and geodynamic models, mapping glacial geomorphology, terrain corrections and filtering of remote sensing observations, and many other science tasks. Is will also be critical for mapping ice traverse routes, landing sites and other field logistics planning. REMA will also provide a critical elevation benchmark for future satellite altimetry missions including ICESat-2. Here we report on REMA production progress, initial accuracy assessment and data availability.

Monitoring high-intensity focused ultrasound (HIFU) therapy using radio frequency ultrasound backscatter to quantify heating

NASA Astrophysics Data System (ADS)

Kaczkowski, Peter J.; Anand, Ajay

2005-09-01

The spatial distribution and temporal history of tissue temperature is an essential indicator of thermal therapy progress, and treatment safety and efficacy. Magnetic resonance methods provide the gold standard noninvasive measurement of temperature but are costly and cumbersome compared to the therapy itself. We have been developing the use of ultrasound backscattering for real-time temperature estimation; ultrasonic methods have been limited to relatively low temperature rise, primarily due to lack of sensitivity at protein denaturation temperatures (50-70°C). Through validation experiments on gel phantoms and ex vivo tissue we show that temperature rise can be accurately mapped throughout the therapeutic temperature range using a new BioHeat Transfer Equation (BHTE) model-constrained inverse approach. Speckle-free temperature and thermal dose maps are generated using the ultrasound calibrated model over the imaged region throughout therapy delivery and post-treatment cooling periods. Results of turkey breast tissue experiments are presented for static HIFU exposures, in which the ultrasound calibrated BHTE temperature maps are shown to be very accurate (within a degree) using independent thermocouple measurements. This new temperature monitoring method may speed clinical adoption of ultrasound-guided HIFU therapy. [Work supported by Army MRMC.

Translation-aware semantic segmentation via conditional least-square generative adversarial networks

NASA Astrophysics Data System (ADS)

Zhang, Mi; Hu, Xiangyun; Zhao, Like; Pang, Shiyan; Gong, Jinqi; Luo, Min

2017-10-01

Semantic segmentation has recently made rapid progress in the field of remote sensing and computer vision. However, many leading approaches cannot simultaneously translate label maps to possible source images with a limited number of training images. The core issue is insufficient adversarial information to interpret the inverse process and proper objective loss function to overcome the vanishing gradient problem. We propose the use of conditional least squares generative adversarial networks (CLS-GAN) to delineate visual objects and solve these problems. We trained the CLS-GAN network for semantic segmentation to discriminate dense prediction information either from training images or generative networks. We show that the optimal objective function of CLS-GAN is a special class of f-divergence and yields a generator that lies on the decision boundary of discriminator that reduces possible vanished gradient. We also demonstrate the effectiveness of the proposed architecture at translating images from label maps in the learning process. Experiments on a limited number of high resolution images, including close-range and remote sensing datasets, indicate that the proposed method leads to the improved semantic segmentation accuracy and can simultaneously generate high quality images from label maps.

Geologic map of the Vigo NE quadrangle, Lincoln County, Nevada

USGS Publications Warehouse

Scott, Robert B.; Harding, Anne E.

2006-01-01

This map of the Vigo NE quadrangle, Lincoln County, Nevada records the distribution, stratigraphy, and structural relationships of Tertiary intracaldera lavas and tuffs in the southeastern part of the Kane Springs Wash caldera, extracaldera Tertiary and upper Paleozoic rocks, and late Cenozoic surficial deposits both within and outside the caldera. The alkaline to peralkaline Kane Springs Wash caldera is the youngest (14 Ma) of three chemically related metaluminous to peralkaline calderas (Boulder Canyon caldera, 15 Ma; Narrow Canyon caldera, 16 Ma) of the nested Kane Springs Wash caldera complex. The chemistry of this caldera complex became progressively more alkalic with time, in contrast to the older calc-alkalic calderas and caldera complexes to the north that migrated progressively southward in eastern Nevada. The increasingly peralkaline eruptions from the Kane Springs Wash caldera complex reached a climax that was simultaneous with the end of both rapid extension and magmatism in this part of the Basin and Range. Using the assumption that degree of tilting is related to the degree of extension, the rate of extension increased until the abrupt halt at about 14 Ma. Silicic volcanism terminated at the Kane Springs Wash caldera followed only by local sporadic basaltic eruptions that ended by about 8 Ma. The northern boundary of an east-west-trending amagmatic corridor appears in the Vigo NE quadrangle south of the Kane Springs Wash caldera.

Challenges for the functional diffusion map in pediatric brain tumors

PubMed Central

Grech-Sollars, Matthew; Saunders, Dawn E.; Phipps, Kim P.; Kaur, Ramneek; Paine, Simon M.L.; Jacques, Thomas S.; Clayden, Jonathan D.; Clark, Chris A.

2014-01-01

Background The functional diffusion map (fDM) has been suggested as a tool for early detection of tumor treatment efficacy. We aim to study 3 factors that could act as potential confounders in the fDM: areas of necrosis, tumor grade, and change in tumor size. Methods Thirty-four pediatric patients with brain tumors were enrolled in a retrospective study, approved by the local ethics committee, to examine the fDM. Tumors were selected to encompass a range of types and grades. A qualitative analysis was carried out to compare how fDM findings may be affected by each of the 3 confounders by comparing fDM findings to clinical image reports. Results Results show that the fDM in areas of necrosis do not discriminate between treatment response and tumor progression. Furthermore, tumor grade alters the behavior of the fDM: a decrease in apparent diffusion coefficient (ADC) is a sign of tumor progression in high-grade tumors and treatment response in low-grade tumors. Our results also suggest using only tumor area overlap between the 2 time points analyzed for the fDM in tumors of varying size. Conclusions Interpretation of fDM results needs to take into account the underlying biology of both tumor and healthy tissue. Careful interpretation of the results is required with due consideration to areas of necrosis, tumor grade, and change in tumor size. PMID:24305721

Mapping lightning in the sky with a mini array

NASA Astrophysics Data System (ADS)

Füllekrug, Martin; Liu, Zhongjian; Koh, Kuang; Mezentsev, Andrew; Pedeboy, Stéphane; Soula, Serge; Enno, Sven-Erik; Sugier, Jacqueline; Rycroft, Michael J.

2016-10-01

Mini arrays are commonly used for infrasonic and seismic studies. Here we report for the first time the detection and mapping of distant lightning discharges in the sky with a mini array. The array has a baseline to wavelength ratio ˜4.2·10-2 to record very low frequency electromagnetic waves from 2 to 18 kHz. It is found that the mini array detects ˜69 lightning pulses per second from cloud-to-ground and in-cloud discharges, even though the parent thunderstorms are ˜900-1100 km away and a rigorous selection criterion based on the quality of the wavefront across the array is used. In particular, lightning pulses that exhibit a clockwise phase progression are found at larger elevation angles in the sky as the result of a birefringent subionospheric wave propagation attributed to ordinary and extraordinary waves. These results imply that long range lightning detection networks might benefit from an exploration of the wave propagation conditions with mini arrays.

A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping.

PubMed

Wen, Qing; Kim, Chang-Sik; Hamilton, Peter W; Zhang, Shu-Dong

2016-05-11

Gene expression connectivity mapping has gained much popularity recently with a number of successful applications in biomedical research testifying its utility and promise. Previously methodological research in connectivity mapping mainly focused on two of the key components in the framework, namely, the reference gene expression profiles and the connectivity mapping algorithms. The other key component in this framework, the query gene signature, has been left to users to construct without much consensus on how this should be done, albeit it has been an issue most relevant to end users. As a key input to the connectivity mapping process, gene signature is crucially important in returning biologically meaningful and relevant results. This paper intends to formulate a standardized procedure for constructing high quality gene signatures from a user's perspective. We describe a two-stage process for making quality gene signatures using gene expression data as initial inputs. First, a differential gene expression analysis comparing two distinct biological states; only the genes that have passed stringent statistical criteria are considered in the second stage of the process, which involves ranking genes based on statistical as well as biological significance. We introduce a "gene signature progression" method as a standard procedure in connectivity mapping. Starting from the highest ranked gene, we progressively determine the minimum length of the gene signature that allows connections to the reference profiles (drugs) being established with a preset target false discovery rate. We use a lung cancer dataset and a breast cancer dataset as two case studies to demonstrate how this standardized procedure works, and we show that highly relevant and interesting biological connections are returned. Of particular note is gefitinib, identified as among the candidate therapeutics in our lung cancer case study. Our gene signature was based on gene expression data from Taiwan female non-smoker lung cancer patients, while there is evidence from independent studies that gefitinib is highly effective in treating women, non-smoker or former light smoker, advanced non-small cell lung cancer patients of Asian origin. In summary, we introduced a gene signature progression method into connectivity mapping, which enables a standardized procedure for constructing high quality gene signatures. This progression method is particularly useful when the number of differentially expressed genes identified is large, and when there is a need to prioritize them to be included in the query signature. The results from two case studies demonstrate that the approach we have developed is capable of obtaining pertinent candidate drugs with high precision.

St. Louis Area Earthquake Hazards Mapping Project - December 2008-June 2009 Progress Report

USGS Publications Warehouse

Williams, R.A.; Bauer, R.A.; Boyd, O.S.; Chung, J.; Cramer, C.H.; Gaunt, D.A.; Hempen, G.L.; Hoffman, D.; McCallister, N.S.; Prewett, J.L.; Rogers, J.D.; Steckel, P.J.; Watkins, C.M.

2009-01-01

This report summarizes the mission, the project background, the participants, and the progress of the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) for the period from December 2008 through June 2009. During this period, the SLAEHMP held five conference calls and two face-to-face meetings in St. Louis, participated in several earthquake awareness public meetings, held one outreach field trip for the business and government community, collected and compiled new borehole and digital elevation data from partners, and published a project summary.

Mobile Robot Self-Localization by Matching Range Maps Using a Hausdorff Measure

NASA Technical Reports Server (NTRS)

Olson, C. F.

1997-01-01

This paper examines techniques for a mobile robot to perform self-localization in natural terrain by comparing a dense range map computed from stereo imagery to a range map in a known frame of reference.

Mapping day-of-burning with coarse-resolution satellite fire-detection data

Treesearch

Sean A. Parks

2014-01-01

Evaluating the influence of observed daily weather on observed fire-related effects (e.g. smoke production, carbon emissions and burn severity) often involves knowing exactly what day any given area has burned. As such, several studies have used fire progression maps ­ in which the perimeter of an actively burning fire is mapped at a fairly high temporal resolution -...

A Method to Reveal Fine-Grained and Diverse Conceptual Progressions during Learning

ERIC Educational Resources Information Center

Lombard, François; Merminod, Marie; Widmer, Vincent; Schneider, Daniel K.

2018-01-01

Empirical data on learners' conceptual progression is required to design curricula and guide students. In this paper, we present the Reference Map Change Coding (RMCC) method for revealing students' progression at a fine-grained level. The method has been developed and tested through the analysis of successive versions of the productions of eight…

Building consensus and partnerships for implementing the MAP-21 section 5310 program in California.

DOT National Transportation Integrated Search

2014-04-01

The Moving Ahead for Progress in the 21st Century Act (MAP-21)the legislation that currently provides funding for federal : transportationallows metropolitan planning organizations (MPOs) or eligible large, urbanized area (UZA) agencies to assu...

Internationalization Revisited

ERIC Educational Resources Information Center

Peterson, Patti McGill; Helms, Robin Matross

2013-01-01

For the last decade, the American Council on Education (ACE) has charted higher education's progress towards internationalization through its Mapping Internationalization on US Campuses project. Using surveys of US institutions conducted in 2001, 2006, and 2011, the Mapping study examines strategic planning, the curriculum, faculty policies and…

[Mechanisms of inhibition of viral replication in plants]. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-09-01

Progress is described concerning genetic mapping CMV movement genes for CMV coat protein in squash and ToMV gene in tomato. These gene products appear to be involved in resistance to squash and tomato mosaic viruses respectively.

Abstracts of the Annual Meeting of Planetary Geologic Mappers, Tucson, AZ 2007

USGS Publications Warehouse

Gregg, Tracy K.P.; Tanaka, Kenneth L.; Saunders, R. Stephen; Bleamaster, Leslie F.

2007-01-01

Introduction Report of the Annual Mappers Meeting Planetary Science Institute Tucson, Arizona June 28 and 29, 2007 Approximately 22 people attended this year's mappers meeting, and many more submitted abstracts and maps in absentia. The 2007 meeting was convened by Tracy Gregg, Les Bleamaster, Steve Saunders, and Ken Tanaka and was hosted by David Crown and Les Bleamaster of the Planetary Science Institute (PSI) in Tucson, Arizona. Oral presentations and poster discussions took place on Thursday, June 28 and Friday, June 29. This year's meeting also included a unique opportunity to visit the operations centers of two active Mars missions; field trips to the University of Arizona took place on Thursday and Friday afternoons. Outgoing Geologic Mapping Subcommittee (GEMS) chairperson, Tracy Gregg, commenced the meeting with an introduction and David Crown followed with a discussion of logistics and the PSI facility; Steve Saunders (Planetary Geology and Geophysics Discipline Scientist) then provided a brief program update. Science presentations kicked off with Venus mapper Vicki Hansen and graduate students Eric Tharalson and Bhairavi Shankar of the University of Minnesota, Duluth, showing a 3-D animation of the global distribution of tesserae and discussing the implications, a progress report for V-45 quadrangle mapping, and a brief discussion of circular lows. Les Bleamaster (PSI) followed with a progress report on mapping of the V-50 quadrangle and the 1:10M Helen Planitia quadrangle. David Crown (PSI) concluded the Venus presentations with a discussion of progress made on the V-30 quadrangle. The remainder of Thursday's presentations jumped around the Solar System including Mars, Io, and Earth. Ken Tanaka of the U.S. Geological Survey (USGS) began the afternoon with a general discussion of the status of the planetary mapping program at USGS. Buck Janes (University of Arizona) provided background information about the Mars Odyssey Gamma Ray Spectrometer (GRS) and presented some new element maps, which may be useful for geologic mapping. Dave Williams of Arizona State University reported on the progress of his global Io map and James Dohm (University of Arizona) discussed results of terrestrial remote mapping studies. Thursday afternoon, the mappers were given a tour of the High Resolution Imaging Science Experiment (HiRISE) operations facility and were given some basic information about how the images are obtained, processed, and publicly released. With official GEMS transition completed at lunch on Thursday, incoming GEMS chair Leslie Bleamaster took the reigns of Friday's meeting. Science presentations began with Ken Tanaka discussing 1:20M-scale global and 1:2M-scale polar mapping of Mars. Jim Zimbelman (Smithsonian Institution) described his 1:1M Medusae Fossae map (MC-8 SE), which is nearing completion, and new mapping (MC-16 NW and MC-23 NW) to further evaluate the Medusae Fossae. Brent Garry, also of the Smithsonian Institution, presented work on Ascraeus Mons. Peter Mouginis-Mark (University of Hawai`i) reported progress on his 1:200K and larger maps of Tooting crater and of the Olympus Mons summit caldera. Laszlo Keszthelyi (USGS) presented mapping of Athabasca Valles, with much of the credit going to Windy Jaeger. Jim Skinner (USGS) introduced a new mapping project including nine MTM quadrangles in the Utopia Planitia region. Tracy Gregg finished off the day's science presentations with discussion of Hesperia Planum. After discussion was complete, the group once again traveled to the University of Arizona - this time for a tour of the Mars Phoenix operations center. Principal Investigator Peter Smith beamed as he led mappers through the multi-million dollar facility. A main topic of discussion throughout the entire meeting was that of nomenclature, specifically how to classify the individual depressions at the tops of volcanoes. Paterae, as has been used for Mars, Venus, and Io, was suggested, but i

Scientists Develop Precision Maps for Other Planets

NASA Astrophysics Data System (ADS)

Kumar, Mohi

2013-03-01

Earth and planetary scientists are united by their need for accurate maps. Without them, features studied have no reference point, attempts to understand how our and other planets evolved have no context, and missions flown to other planets lack purpose. "Making maps out of data is critical to further progress in our fields," explained Randolph Kirk of the U.S. Geological Survey's (USGS) Astrogeology Science Center, based in Flagstaff, Ariz. "Building maps helps other people find what's out there."

CrowdMapping: A Crowdsourcing-Based Terminology Mapping Method for Medical Data Standardization.

PubMed

Mao, Huajian; Chi, Chenyang; Huang, Boyu; Meng, Haibin; Yu, Jinghui; Zhao, Dongsheng

2017-01-01

Standardized terminology is the prerequisite of data exchange in analysis of clinical processes. However, data from different electronic health record systems are based on idiosyncratic terminology systems, especially when the data is from different hospitals and healthcare organizations. Terminology standardization is necessary for the medical data analysis. We propose a crowdsourcing-based terminology mapping method, CrowdMapping, to standardize the terminology in medical data. CrowdMapping uses a confidential model to determine how terminologies are mapped to a standard system, like ICD-10. The model uses mappings from different health care organizations and evaluates the diversity of the mapping to determine a more sophisticated mapping rule. Further, the CrowdMapping model enables users to rate the mapping result and interact with the model evaluation. CrowdMapping is a work-in-progress system, we present initial results mapping terminologies.

Geologic map of the greater Denver area, Front Range urban corridor, Colorado

USGS Publications Warehouse

Trimble, Donald E.; Machette, Michael N.

1979-01-01

This digital map shows the areal extent of surficial deposits and rock stratigraphic units (formations) as compiled by Trimble and Machette from 1973 to 1977 and published in 1979 under the Front Range Urban Corridor Geology Program. Trimble and Machette compiled their geologic map from published geologic maps and unpublished geologic mapping having varied map unit schemes. A convenient feature of the compiled map is its uniform classification of geologic units that mostly matches those of companion maps to the north (USGS I-855-G) and to the south (USGS I-857-F). Published as a color paper map, the Trimble and Machette map was intended for land-use planning in the Front Range Urban Corridor. This map recently (1997-1999) was digitized under the USGS Front Range Infrastructure Resources Project. In general, the mountainous areas in the western part of the map exhibit various igneous and metamorphic bedrock units of Precambrian age, major faults, and fault brecciation zones at the east margin (5-20 km wide) of the Front Range. The eastern and central parts of the map (Colorado Piedmont) depict a mantle of unconsolidated deposits of Quaternary age and interspersed outcroppings of Cretaceous or Tertiary-Cretaceous sedimentary bedrock. The Quaternary mantle comprises eolian deposits (quartz sand and silt), alluvium (gravel, sand, and silt of variable composition), colluvium, and a few landslides. At the mountain front, north-trending, dipping Paleozoic and Mesozoic sandstone, shale, and limestone bedrock formations form hogbacks and intervening valleys.

A spatial database of bedding attitudes to accompany Geologic map of the greater Denver area, Front Range Urban Corridor, Colorado

USGS Publications Warehouse

Trimble, Donald E.; Machette, Michael N.; Brandt, Theodore R.; Moore, David W.; Murray, Kyle E.

2003-01-01

This digital map shows bedding attitude symbols display over the geographic extent of surficial deposits and rock stratigraphic units (formations) as compiled by Trimble and Machette 1973-1977 and published in 1979 (U.S. Geological Survey Map I-856-H) under the Front Range Urban Corridor Geology Program. Trimble and Machette compiled their geologic map from published geologic maps and unpublished geologic mapping having varied map unit schemes. A convenient feature of the compiled map is its uniform classification of geologic units that mostly matches those of companion maps to the north (USGS I-855-G) and to the south (USGS I-857-F). Published as a color paper map, the Trimble and Machette map was intended for land-use planning in the Front Range Urban Corridor. This map recently (1997-1999), was digitized under the USGS Front Range Infrastructure Resources Project (see cross-reference). In general, the mountainous areas in the west part of the map exhibit various igneous and metamorphic bedrock units of Precambrian age, major faults, and fault brecciation zones at the east margin (5-20 km wide) of the Front Range. The eastern and central parts of the map (Colorado Piedmont) depict a mantle of unconsolidated deposits of Quaternary age and interspersed outcroppings of Cretaceous or Tertiary-Cretaceous sedimentary bedrock. The Quaternary mantle is comprised of eolian deposits (quartz sand and silt), alluvium (gravel, sand, and silt of variable composition), colluvium, and few landslides. At the mountain front, north-trending, dipping Paleozoic and Mesozoic sandstone, shale, and limestone bedrock formations form hogbacks and intervening valleys.

A Progressive, Collaborative Process to Improve a Curriculum and Define an Assessment Program.

PubMed

Letassy, Nancy A; Medina, Melissa S; Britton, Mark L; Dennis, Vince; Draugalis, JoLaine R

2015-05-25

To revise the University of Oklahoma College of Pharmacy's professional program outcomes and create an assessment map using results from previous peer review and mapping of all professional courses and curricular streams of knowledge, skills, and attitudes (KSAs). After consolidating 15 original program outcomes into 11 more precise outcome statements, defining KSAs for each, and getting faculty approval of them, the committee detailed measurable program expectations upon graduation for each outcome and created an assessment map identifying where KSAs were taught, how they were to be assessed, and the expected ability level (novice, competent, proficient) for each across the curriculum. The committee's work identified deficits, inconsistencies, and disproportionalities in professional program assessment. It recommended assessments to capture student achievement of each outcome, identified performance levels and criteria to measure outcomes progressively in each professional year, and outlined a process to provide students periodic reports on their progress in achieving each outcome. This work establishes a firm foundation for ongoing efforts to measure effectiveness of the professional program, especially in light of Accreditation Council for Pharmacy Education's (ACPE) revised accreditation standards.

Some Thoughts on "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"

ERIC Educational Resources Information Center

Kingston, Neal M.; Broaddus, Angela; Lao, Hongling

2015-01-01

Briggs and Peck (2015) have written a thought-provoking article on the use of learning progressions in the design of vertical scales that support inferences about student growth. Organized learning models, including learning trajectories, learning progressions, and learning maps have been the subject of research for many years, but more recently…

Road Maps for Learning: A Guide to the Navigation of Learning Progressions

ERIC Educational Resources Information Center

Black, Paul; Wilson, Mark; Yao, Shih-Ying

2011-01-01

The overall aim of this article is to analyze the relationships between the roles of assessment in pedagogy, the interactions between curriculum assessment and pedagogy, and the study of pupils' progression in learning. It is argued that well-grounded evidence of pupils' progressions in learning is crucial to the work of teachers, so that a method…

Mathematical analysis of running performance and world running records.

PubMed

Péronnet, F; Thibault, G

1989-07-01

The objective of this study was to develop an empirical model relating human running performance to some characteristics of metabolic energy-yielding processes using A, the capacity of anaerobic metabolism (J/kg); MAP, the maximal aerobic power (W/kg); and E, the reduction in peak aerobic power with the natural logarithm of race duration T, when T greater than TMAP = 420 s. Accordingly, the model developed describes the average power output PT (W/kg) sustained over any T as PT = [S/T(1 - e-T/k2)] + 1/T integral of T O [BMR + B(1 - e-t/k1)]dt where S = A and B = MAP - BMR (basal metabolic rate) when T less than TMAP; and S = A + [Af ln(T/TMAP)] and B = (MAP - BMR) + [E ln(T/TMAP)] when T greater than TMAP; k1 = 30 s and k2 = 20 s are time constants describing the kinetics of aerobic and anaerobic metabolism, respectively, at the beginning of exercise; f is a constant describing the reduction in the amount of energy provided from anaerobic metabolism with increasing T; and t is the time from the onset of the race. This model accurately estimates actual power outputs sustained over a wide range of events, e.g., average absolute error between actual and estimated T for men's 1987 world records from 60 m to the marathon = 0.73%. In addition, satisfactory estimations of the metabolic characteristics of world-class male runners were made as follows: A = 1,658 J/kg; MAP = 83.5 ml O2.kg-1.min-1; 83.5% MAP sustained over the marathon distance. Application of the model to analysis of the evolution of A, MAP, and E, and of the progression of men's and women's world records over the years, is presented.

Geologic Mapping of the Medusae Fossae Formation on Mars (MC-8 SE and MC-23 NW) and the Northern Lowlands of Venus (V-16 and V-15)

NASA Technical Reports Server (NTRS)

Zimbelman, J. R.

2008-01-01

This report summarizes the status of a mapping project supported by NASA grant NNX07AP42G, funding for which became available on July 18, focusing on the mapping of the Medusae Fossae Formation (MFF) on Mars. The report also briefly discusses the status of maps of Venus and Ascraeus Mons, begun under previous NASA grants but which are still in progress.

2. Photographic copy of map. Gila River Project, General Map ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photographic copy of map. Gila River Project, General Map Showing Progress for the Fiscal Year 1927. (Source: U.S. Department of Interior. Office of Indian Affairs. Indian Irrigation Service. Annual Report, Fiscal Year 1927. Vol. I, Narrative and Photographs, District #4, RG 75, Entry 655, Box 29, National Archives, Washington, DC.) Photograph is an 8'x10' enlargement from a 4'x5' negative. - San Carlos Irrigation Project, Lands North & South of Gila River, Coolidge, Pinal County, AZ

A spatial database of bedding attitudes to accompany Geologic Map of Boulder-Fort Collins-Greeley Area, Colorado

USGS Publications Warehouse

Colton, Roger B.; Brandt, Theodore R.; Moore, David W.; Murray, Kyle E.

2003-01-01

This digital map shows bedding attitude data displayed over the geographic extent of rock stratigraphic units (formations) as compiled by Colton in 1976 (U.S.Geological Survey Map I-855-G) under the Front Range Urban Corridor Geology Program. Colton used his own mapping and published geologic maps having varied map unit schemes to compile one map with a uniform classification of geologic units. The resulting published color paper map was intended for planning for use of land in the Front Range Urban Corridor. In 1997-1999, under the USGS Front Range Infrastructure Resources Project, Colton's map was digitized to provide data at 1:100,000 scale to address urban growth issues(see cross-reference). In general, the west part of the map shows a variety of Precambrian igneous and metamorphic rocks, major faults and brecciated zones along an eastern strip (5-20 km wide) of the Front Range. The eastern and central part of the map (Colorado Piedmont) depicts a mantle of Quaternary unconsolidated deposits and interspersed Cretaceous or Tertiary-Cretaceous sedimentary rock outcrops. The Quaternary mantle is comprised of eolian deposits (quartz sand and silt), alluvium (gravel, sand, and silt of variable composition), colluvium, and few landslides. At the mountain front, north-trending, dipping Paleozoic and Mesozoic sandstone and shale formations (and sparse limestone) form hogbacks, intervening valleys, and in range-front folds, anticlines, and fault blocks. Localized dikes and sills of Tertiary rhyodacite and basalt intrude rocks near the range front, mostly in the Boulder area.

A feature selection approach towards progressive vector transmission over the Internet

NASA Astrophysics Data System (ADS)

Miao, Ru; Song, Jia; Feng, Min

2017-09-01

WebGIS has been applied for visualizing and sharing geospatial information popularly over the Internet. In order to improve the efficiency of the client applications, the web-based progressive vector transmission approach is proposed. Important features should be selected and transferred firstly, and the methods for measuring the importance of features should be further considered in the progressive transmission. However, studies on progressive transmission for large-volume vector data have mostly focused on map generalization in the field of cartography, but rarely discussed on the selection of geographic features quantitatively. This paper applies information theory for measuring the feature importance of vector maps. A measurement model for the amount of information of vector features is defined based upon the amount of information for dealing with feature selection issues. The measurement model involves geometry factor, spatial distribution factor and thematic attribute factor. Moreover, a real-time transport protocol (RTP)-based progressive transmission method is then presented to improve the transmission of vector data. To clearly demonstrate the essential methodology and key techniques, a prototype for web-based progressive vector transmission is presented, and an experiment of progressive selection and transmission for vector features is conducted. The experimental results indicate that our approach clearly improves the performance and end-user experience of delivering and manipulating large vector data over the Internet.

Mapping Neurodegenerative Disease Onset and Progression.

PubMed

Seeley, William W

2017-08-01

Brain networks have been of long-standing interest to neurodegeneration researchers, including but not limited to investigators focusing on conventional prion diseases, which are known to propagate along neural pathways. Tools for human network mapping, however, remained inadequate, limiting our understanding of human brain network architecture and preventing clinical research applications. Until recently, neuropathological studies were the only viable approach to mapping disease onset and progression in humans but required large autopsy cohorts and laborious methods for whole-brain sectioning and staining. Despite important advantages, postmortem studies cannot address in vivo, physiological, or longitudinal questions and have limited potential to explore early-stage disease except for the most common disorders. Emerging in vivo network-based neuroimaging strategies have begun to address these issues, providing data that complement the neuropathological tradition. Overall, findings to date highlight several fundamental principles of neurodegenerative disease anatomy and pathogenesis, as well as some enduring mysteries. These principles and mysteries provide a road map for future research. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

Procedures for Handling Retaliation Complaints Under Section 31307 of the Moving Ahead for Progress in the 21st Century Act (MAP-21). Final rule.

PubMed

2016-12-14

On March 16, 2016, the Occupational Safety and Health Administration (OSHA) of the U.S. Department of Labor (Department) issued an interim final rule (IFR) that provided procedures for the Department's processing of complaints under the employee protection (retaliation or whistleblower) provisions of Section 31307 of the Moving Ahead for Progress in the 21st Century Act (MAP-21). The IFR established procedures and time frames for the handling of retaliation complaints under MAP-21, including procedures and time frames for employee complaints to OSHA, investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor) and judicial review of the Secretary's final decision. It also set forth the Department's interpretations of the MAP-21 whistleblower provisions on certain matters. This final rule adopts, without change, the IFR.

Build YOUR All-Sky View with Aladin

NASA Astrophysics Data System (ADS)

Oberto, A.; Fernique, P.; Boch, T.; Bonnarel, F.

2011-07-01

From the need to extend the display outside the boundaries of a single image, the Aladin team recently developed a new feature to visualize wide areas or even all of the sky. This all-sky view is particularly useful for visualization of very large objects and, with coverage of the whole sky, maps from the Planck satellite. To improve on this capability, some catalogs and maps have been built from many surveys (e.g., DSS, IRIS, GLIMPSE, SDSS, 2MASS) in mixed resolutions, allowing progressive display. The maps are constructed by mosaicing individual images. Now, we provide a new tool to build an all-sky view with your own images. From the images you have selected, it will compose a mosaic with several resolutions (HEALPix tessellation), and organize them to allow their progressive display in Aladin. For convenience, you can export it to a HEALPix map, or share it with the community through Aladin from your web site or eventually from the CDS image collection.

Recent advancements in nanoelectrodes and nanopipettes used in combined scanning electrochemical microscopy techniques.

PubMed

Kranz, Christine

2014-01-21

In recent years, major developments in scanning electrochemical microscopy (SECM) have significantly broadened the application range of this electroanalytical technique from high-resolution electrochemical imaging via nanoscale probes to large scale mapping using arrays of microelectrodes. A major driving force in advancing the SECM methodology is based on developing more sophisticated probes beyond conventional micro-disc electrodes usually based on noble metals or carbon microwires. This critical review focuses on the design and development of advanced electrochemical probes particularly enabling combinations of SECM with other analytical measurement techniques to provide information beyond exclusively measuring electrochemical sample properties. Consequently, this critical review will focus on recent progress and new developments towards multifunctional imaging.

Posttraumatic Stress Disorder: Five Vicious Cycles that Inhibit Effective Treatment.

PubMed

Ghaffarzadegan, Navid; Larson, Richard C

2015-01-01

Despite a wide range of studies and medical progress, it seems that we are far from significantly mitigating the problem of posttraumatic stress disorder (PTSD). The problem has major social and behavioral components. Developing innovative and effective policies requires a broad scope of analysis and consideration of the highly interconnected social, behavioral, and medical variables. In this article, we take a systems approach and offer an illustrative causal loop diagram which includes individual and social dynamics. Based on the map, we discuss 5 major barriers for effective interventions in PTSD. These barriers work as vicious cycles in the system, reduce effectiveness and therefore value of PTSD treatment. We also discuss policy implications of this perspective.

Application of Handheld Laser-Induced Breakdown Spectroscopy (LIBS) to Geochemical Analysis.

PubMed

Connors, Brendan; Somers, Andrew; Day, David

2016-05-01

While laser-induced breakdown spectroscopy (LIBS) has been in use for decades, only within the last two years has technology progressed to the point of enabling true handheld, self-contained instruments. Several instruments are now commercially available with a range of capabilities and features. In this paper, the SciAps Z-500 handheld LIBS instrument functionality and sub-systems are reviewed. Several assayed geochemical sample sets, including igneous rocks and soils, are investigated. Calibration data are presented for multiple elements of interest along with examples of elemental mapping in heterogeneous samples. Sample preparation and the data collection method from multiple locations and data analysis are discussed. © The Author(s) 2016.

Range maps of terrestrial species in the interior Columbia River basin and northern portions of the Klamath and Great Basins.

Treesearch

Bruce G. Marcot; Barbara C. Wales; Rick Demmer

2003-01-01

Current range distribution maps are presented for 14 invertebrate, 26 amphibian, 26 reptile, 339 bird, and 125 mammal species and selected subspecies (530 total taxa) of the interior Columbia River basin and northern portions of the Klamath and Great Basins in the United States. Also presented are maps of historical ranges of 3 bird and 10 mammal species, and 6 maps of...

Mapping the Stacks: Sustainability and User Experience of Animated Maps in Library Discovery Interfaces

ERIC Educational Resources Information Center

McMillin, Bill; Gibson, Sally; MacDonald, Jean

2016-01-01

Animated maps of the library stacks were integrated into the catalog interface at Pratt Institute and into the EBSCO Discovery Service interface at Illinois State University. The mapping feature was developed for optimal automation of the update process to enable a range of library personnel to update maps and call-number ranges. The development…

Prismatic displacement effect of progressive multifocal glasses on reaction time and accuracy in elderly people.

PubMed

Ellison, Ashton C; Campbell, A John; Robertson, M Clare; Sanderson, Gordon F

2014-01-01

Multifocal glasses (bifocals, trifocals, and progressives) increase the risk of falling in elderly people, but how they do so is unclear. To explain why glasses with progressive addition lenses increase the risk of falls and whether this can be attributed to false projection, this study aimed to 1) map the prismatic displacement of a progressive lens, and 2) test whether this displacement impaired reaction time and accuracy. The reaction times of healthy ≥75-year-olds (31 participants) were measured when grasping for a bar and touching a black line. Participants performed each test twice, wearing their progressives and new, matched single vision (distance) glasses in random order. The line and bar targets were positioned according to the maximum and minimum prismatic displacement effect through the progressive lens, mapped using a focimeter. Progressive spectacle lenses have large areas of prismatic displacement in the central visual axis and edges. Reaction time was faster for progressives compared with single vision glasses with a centrally-placed horizontal grab bar (mean difference 101 ms, P=0.011 [repeated measures analysis]) and a horizontal black line placed 300 mm below center (mean difference 80 ms, P=0.007). There was no difference in accuracy between the two types of glasses. Older people appear to adapt to the false projection of progressives in the central visual axis. This adaptation means that swapping to new glasses or a large change in prescription may lead to a fall. Frequently updating glasses may be more beneficial.

Gamut mapping in a high-dynamic-range color space

NASA Astrophysics Data System (ADS)

Preiss, Jens; Fairchild, Mark D.; Ferwerda, James A.; Urban, Philipp

2014-01-01

In this paper, we present a novel approach of tone mapping as gamut mapping in a high-dynamic-range (HDR) color space. High- and low-dynamic-range (LDR) images as well as device gamut boundaries can simultaneously be represented within such a color space. This enables a unified transformation of the HDR image into the gamut of an output device (in this paper called HDR gamut mapping). An additional aim of this paper is to investigate the suitability of a specific HDR color space to serve as a working color space for the proposed HDR gamut mapping. For the HDR gamut mapping, we use a recent approach that iteratively minimizes an image-difference metric subject to in-gamut images. A psychophysical experiment on an HDR display shows that the standard reproduction workflow of two subsequent transformations - tone mapping and then gamut mapping - may be improved by HDR gamut mapping.

A Renormalisation Group Method. V. A Single Renormalisation Group Step

NASA Astrophysics Data System (ADS)

Brydges, David C.; Slade, Gordon

2015-05-01

This paper is the fifth in a series devoted to the development of a rigorous renormalisation group method applicable to lattice field theories containing boson and/or fermion fields, and comprises the core of the method. In the renormalisation group method, increasingly large scales are studied in a progressive manner, with an interaction parametrised by a field polynomial which evolves with the scale under the renormalisation group map. In our context, the progressive analysis is performed via a finite-range covariance decomposition. Perturbative calculations are used to track the flow of the coupling constants of the evolving polynomial, but on their own perturbative calculations are insufficient to control error terms and to obtain mathematically rigorous results. In this paper, we define an additional non-perturbative coordinate, which together with the flow of coupling constants defines the complete evolution of the renormalisation group map. We specify conditions under which the non-perturbative coordinate is contractive under a single renormalisation group step. Our framework is essentially combinatorial, but its implementation relies on analytic results developed earlier in the series of papers. The results of this paper are applied elsewhere to analyse the critical behaviour of the 4-dimensional continuous-time weakly self-avoiding walk and of the 4-dimensional -component model. In particular, the existence of a logarithmic correction to mean-field scaling for the susceptibility can be proved for both models, together with other facts about critical exponents and critical behaviour.

Progressive myoclonus epilepsy EPM1 locus maps to a 175-kb interval in distal 21q

DOE Office of Scientific and Technical Information (OSTI.GOV)

Virtaneva, K.; Miao, J.; Traeskelin, A.L.

1996-06-01

The EPM1 locus responsible for progressive myoclonus epilepsy of Unverricht-Lundborg type (MIM 254800) maps to a region in distal chromosome 21q where positional cloning has been hampered by the lack of physical and genetic mapping resolution. We here report the use of a recently constituted contig of cosmid, BAC, and P1 clones that allowed new polymorphic markers to be positioned. These were typed in 53 unrelated disease families from an isolated Finnish population in which a putative single ancestral EPM1 mutation has segregated for an estimated 100 generations. By thus exploiting historical recombinations in haplotype analysis, EPM1 could be assignedmore » to the {approximately}175-kb interval between the markers D21S2040 and D21S1259. 26 refs., 2 figs., 4 tabs.« less

Atom Interferometer Technologies in Space for Gravity Mapping and Gravity Science

NASA Astrophysics Data System (ADS)

Williams, Jason; Chiow, Sheng-Wey; Kellogg, James; Kohel, James; Yu, Nan

2015-05-01

Atom interferometers utilize the wave-nature of atomic gases for precision measurements of inertial forces, with potential applications ranging from gravity mapping for planetary science to unprecedented tests of fundamental physics with quantum gases. The high stability and sensitivity intrinsic to these devices already place them among the best terrestrial sensors available for measurements of gravitational accelerations, rotations, and gravity gradients, with the promise of several orders of magnitude improvement in their detection sensitivity in microgravity. Consequently, multiple precision atom-interferometer-based projects are under development at the Jet Propulsion Laboratory, including a dual-atomic-species interferometer that is to be integrated into the Cold Atom Laboratory onboard the International Space Station and a highly stable gravity gradiometer in a transportable design relevant for earth science measurements. We will present JPL's activities in the use of precision atom interferometry for gravity mapping and gravitational wave detection in space. Our recent progresses bringing the transportable JPL atom interferometer instrument to be competitive with the state of the art and simulations of the expected capabilities of a proposed flight project will also be discussed. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

Advances in Maize Genomics and Their Value for Enhancing Genetic Gains from Breeding

PubMed Central

Xu, Yunbi; Skinner, Debra J.; Wu, Huixia; Palacios-Rojas, Natalia; Araus, Jose Luis; Yan, Jianbing; Gao, Shibin; Warburton, Marilyn L.; Crouch, Jonathan H.

2009-01-01

Maize is an important crop for food, feed, forage, and fuel across tropical and temperate areas of the world. Diversity studies at genetic, molecular, and functional levels have revealed that, tropical maize germplasm, landraces, and wild relatives harbor a significantly wider range of genetic variation. Among all types of markers, SNP markers are increasingly the marker-of-choice for all genomics applications in maize breeding. Genetic mapping has been developed through conventional linkage mapping and more recently through linkage disequilibrium-based association analyses. Maize genome sequencing, initially focused on gene-rich regions, now aims for the availability of complete genome sequence. Conventional insertion mutation-based cloning has been complemented recently by EST- and map-based cloning. Transgenics and nutritional genomics are rapidly advancing fields targeting important agronomic traits including pest resistance and grain quality. Substantial advances have been made in methodologies for genomics-assisted breeding, enhancing progress in yield as well as abiotic and biotic stress resistances. Various genomic databases and informatics tools have been developed, among which MaizeGDB is the most developed and widely used by the maize research community. In the future, more emphasis should be given to the development of tools and strategic germplasm resources for more effective molecular breeding of tropical maize products. PMID:19688107

Use of GIS Mapping as a Public Health Tool—From Cholera to Cancer

PubMed Central

Musa, George J.; Chiang, Po-Huang; Sylk, Tyler; Bavley, Rachel; Keating, William; Lakew, Bereketab; Tsou, Hui-Chen; Hoven, Christina W.

2013-01-01

The field of medical geographic information systems (Medical GIS) has become extremely useful in understanding the bigger picture of public health. The discipline holds a substantial capacity to understand not only differences, but also similarities in population health all over the world. The main goal of marrying the disciplines of medical geography, public health and informatics is to understand how countless health issues impact populations, and the trends by which these populations are affected. From the 1990s to today, this practical approach has become a valued and progressive system in analyzing medical and epidemiological phenomena ranging from cholera to cancer. The instruments supporting this field include geographic information systems (GIS), disease surveillance, big data, and analytical approaches like the Geographical Analysis Machine (GAM), Dynamic Continuous Area Space Time Analysis (DYCAST), cellular automata, agent-based modeling, spatial statistics and self-organizing maps. The positive effects on disease mapping have proven to be tremendous as these instruments continue to have a great impact on the mission to improve worldwide health care. While traditional uses of GIS in public health are static and lacking real-time components, implementing a space-time animation in these instruments will be monumental as technology and data continue to grow. PMID:25114567

Use of GIS Mapping as a Public Health Tool-From Cholera to Cancer.

PubMed

Musa, George J; Chiang, Po-Huang; Sylk, Tyler; Bavley, Rachel; Keating, William; Lakew, Bereketab; Tsou, Hui-Chen; Hoven, Christina W

2013-01-01

The field of medical geographic information systems (Medical GIS) has become extremely useful in understanding the bigger picture of public health. The discipline holds a substantial capacity to understand not only differences, but also similarities in population health all over the world. The main goal of marrying the disciplines of medical geography, public health and informatics is to understand how countless health issues impact populations, and the trends by which these populations are affected. From the 1990s to today, this practical approach has become a valued and progressive system in analyzing medical and epidemiological phenomena ranging from cholera to cancer. The instruments supporting this field include geographic information systems (GIS), disease surveillance, big data, and analytical approaches like the Geographical Analysis Machine (GAM), Dynamic Continuous Area Space Time Analysis (DYCAST), cellular automata, agent-based modeling, spatial statistics and self-organizing maps. The positive effects on disease mapping have proven to be tremendous as these instruments continue to have a great impact on the mission to improve worldwide health care. While traditional uses of GIS in public health are static and lacking real-time components, implementing a space-time animation in these instruments will be monumental as technology and data continue to grow.

Database for the Geologic Map of Upper Eocene to Holocene Volcanic and Related Rocks of the Cascade Range, Oregon

USGS Publications Warehouse

Nimz, Kathryn; Ramsey, David W.; Sherrod, David R.; Smith, James G.

2008-01-01

Since 1979, Earth scientists of the Geothermal Research Program of the U.S. Geological Survey have carried out multidisciplinary research in the Cascade Range. The goal of this research is to understand the geology, tectonics, and hydrology of the Cascades in order to characterize and quantify geothermal resource potential. A major goal of the program is compilation of a comprehensive geologic map of the entire Cascade Range that incorporates modern field studies and that has a unified and internally consistent explanation. This map is one of three in a series that shows Cascade Range geology by fitting published and unpublished mapping into a province-wide scheme of rock units distinguished by composition and age; map sheets of the Cascade Range in Washington (Smith, 1993) and California will complete the series. The complete series forms a guide to exploration and evaluation of the geothermal resources of the Cascade Range and will be useful for studies of volcano hazards, volcanology, and tectonics. This digital release contains all the information used to produce the geologic map published as U.S. Geological Survey Geologic Investigations Series I-2569 (Sherrod and Smith, 2000). The main component of this digital release is a geologic map database prepared using ArcInfo GIS. This release also contains files to view or print the geologic map and accompanying descriptive pamphlet from I-2569.

Integrating recent land cover mapping efforts to update the National Gap Analysis Program's species habitat map

USGS Publications Warehouse

McKerrow, Alexa; Davidson, A.; Earnhardt, Todd; Benson, Abigail L.; Toth, Charles; Holm, Thomas; Jutz, Boris

2014-01-01

Over the past decade, great progress has been made to develop national extent land cover mapping products to address natural resource issues. One of the core products of the GAP Program is range-wide species distribution models for nearly 2000 terrestrial vertebrate species in the U.S. We rely on deductive modeling of habitat affinities using these products to create models of habitat availability. That approach requires that we have a thematically rich and ecologically meaningful map legend to support the modeling effort. In this work, we tested the integration of the Multi-Resolution Landscape Characterization Consortium's National Land Cover Database 2011 and LANDFIRE's Disturbance Products to update the 2001 National GAP Vegetation Dataset to reflect 2011 conditions. The revised product can then be used to update the species models. We tested the update approach in three geographic areas (Northeast, Southeast, and Interior Northwest). We used the NLCD product to identify areas where the cover type mapped in 2011 was different from what was in the 2001 land cover map. We used Google Earth and ArcGIS base maps as reference imagery in order to label areas identified as "changed" to the appropriate class from our map legend. Areas mapped as urban or water in the 2011 NLCD map that were mapped differently in the 2001 GAP map were accepted without further validation and recoded to the corresponding GAP class. We used LANDFIRE's Disturbance products to identify changes that are the result of recent disturbance and to inform the reassignment of areas to their updated thematic label. We ran species habitat models for three species including Lewis's Woodpecker (Melanerpes lewis) and the White-tailed Jack Rabbit (Lepus townsendii) and Brown Headed nuthatch (Sitta pusilla). For each of three vertebrate species we found important differences in the amount and location of suitable habitat between the 2001 and 2011 habitat maps. Specifically, Brown headed nuthatch habitat in 2011 was −14% of the 2001 modeled habitat, whereas Lewis's Woodpecker increased by 4%. The white-tailed jack rabbit (Lepus townsendii) had a net change of −1% (11% decline, 10% gain). For that species we found the updates related to opening of forest due to burning and regenerating shrubs following harvest to be the locally important main transitions. In the Southeast updates related to timber management and urbanization are locally important.

Completion of the 1:1,500,000-Scale Geologic Map of Western Libya Montes and Northwestern Tyrrhena Terra

NASA Astrophysics Data System (ADS)

Huff, A. E.; Skinner, J. A.

2018-06-01

Final progress report on the 1:1,500,000-scale mapping of western Libya Montes and northwestern Tyrrhena Terra. The final unit names, labels, and descriptions are reported as well as the methodology for age determinations and brief geologic history.

Linking the ACT ASPIRE Assessments to NWEA MAP Assessments

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Auditing and Mapping Key Skills within University Curricula

ERIC Educational Resources Information Center

Tariq, Vicki N.; Scott, Eileen M.; Cochrane, A. Clive; Lee, Maria; Ryles, Linda

2004-01-01

Universities are encouraged to embed key skills in their undergraduate curricula, yet there is often little support on how to identify skills development and progression. This paper describes a tool that facilitates colleagues in auditing key skills and career/employability skills within individual modules and mapping these skills across degree…

Intra-operative mapping of the atria: the first step towards individualization of atrial fibrillation therapy?

PubMed

Kik, Charles; Mouws, Elisabeth M J P; Bogers, Ad J J C; de Groot, Natasja M S

2017-07-01

Atrial fibrillation (AF), an age-related progressive disease, is becoming a worldwide epidemic with a prevalence rate of 33 million. Areas covered: In this expert review, an overview of important results obtained from previous intra-operative mapping studies is provided. In addition, our novel intra-operative high resolution mapping studies, its surgical considerations and data analyses are discussed. Furthermore, the importance of high resolution mapping studies of both sinus rhythm and AF for the development of future AF therapy is underlined by our most recent results. Expert commentary: Progression of AF is determined by the extensiveness of electropathology which is defined as conduction disorders caused by structural damage of atrial tissue. The severity of electropathology is a major determinant of therapy failure. At present, we do not have any diagnostic tool to determine the degree of electropathology in the individual patient and we can thus not select the most optimal treatment modality for the individual patient. An intra-operative, high resolution scale, epicardial mapping approach combined with quantification of electrical parameters may serve as a diagnostic tool to stage AF in the individual patient and to provide patient tailored therapy.

2015 NWEA Measures of Academic Progress Normative Data

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2015

2015-01-01

By using carefully constructed measurement scales that span grades, Measures of Academic Progress (MAP) interim assessments from Northwest Evaluation Association™ (NWEA™) offer educators efficient and very accurate estimates of student achievement status within a subject. Before achievement test scores can be useful to educators, however, they…

Geodesy and cartography of the Martian satellites

NASA Technical Reports Server (NTRS)

Batson, R. M.; Edwards, Kathleen; Duxbury, T. C.

1992-01-01

The difficulties connected with conventional maps of Phobos and Deimos are largely overcome by producing maps in digital forms, i.e., by projecting Viking Orbiter images onto a global topographic model made from collections of radii derived by photogrammetry. The resulting digital mosaics are then formatted as arrays of body-centered latitudes, longitudes, radii, and brightness values of Viking Orbiter images. The Phobos mapping described was done with Viking Orbiter data. Significant new coverage was obtained by the Soviet Phobos mission. The mapping of Deimos is in progress, using the techniques developed for Phobos.

Modular avionics packaging standardization

NASA Astrophysics Data System (ADS)

Austin, M.; McNichols, J. K.

The Modular Avionics Packaging (MAP) Program for packaging future military avionics systems with the objective of improving reliability, maintainability, and supportability, and reducing equipment life cycle costs is addressed. The basic MAP packaging concepts called the Standard Avionics Module, the Standard Enclosure, and the Integrated Rack are summarized, and the benefits of modular avionics packaging, including low risk design, technology independence with common functions, improved maintainability and life cycle costs are discussed. Progress made in MAP is briefly reviewed.

Abstracts of the Annual Meeting of Planetary Geologic Mappers, Flagstaff, AZ, 2010

NASA Technical Reports Server (NTRS)

Bleamaster, Leslie F., III (Editor); Tanaka, Kenneth L. (Editor); Kelley, Michael S. (Editor)

2010-01-01

Topics covered include: Detailed Analysis of the Intra-Ejecta Dark Plains of Caloris Basin, Mercury; The Formation and Evolution of Tessera and Insights into the Beginning of Recorded History on Venus: Geology of the Fortuna Tessera Quadrangle (V-2); Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for the Volcanic History of the North Polar Region of Venus; Geological Map of the Fredegonade (V-57) Quadrangle, Venus: Status Report; Geologic Mapping of V-19; Geology of the Lachesis Tessera Quadrangle (V-18), Venus; Comparison of Mapping Tessera Terrain in the Phoebe Regio (V-41) and Tellus Tessera (V-10) Quadrangles; Geologic Mapping of the Devana Chasma (V-29) Quadrangle, Venus; Geologic Mapping of the Aristarchus Plateau Region on the Moon; Geologic Mapping of the Lunar South Pole Quadrangle (LQ-30); The Pilot Lunar Geologic Mapping Project: Summary Results and Recommendations from the Copernicus Quadrangle; Geologic Mapping of the Nili Fossae Region of Mars: MTM Quadrangles 20287, 20282, 25287, 25282, 30287, and 30282; Geologic Mapping of the Mawrth Vallis Region, Mars: MTM Quadrangles 25022, 25017, 25012, 20022, 20017, and 20012; Evidence for an Ancient Buried Landscape on the NW Rim of Hellas Basin, Mars; New Geologic Map of the Argyre Region of Mars: Deciphering the Geologic History Through Mars Global Surveyor, Mars Odyssey, and Mars Express Data; Geologic Mapping in the Hesperia Planum Region of Mars; Geologic Mapping of the Meridiani Region of Mars; Geologic Mapping in Southern Margaritifer Terra; Geology of -30247, -35247, and -40247 Quadrangles, Southern Hesperia Planum, Mars; The Interaction of Impact Melt, Impact-Derived Sediment, and Volatiles at Crater Tooting, Mars; Geologic Map of the Olympia Cavi Region of Mars (MTM 85200): A Summary of Tactical Approaches; Geology of the Terra Cimmeria-Utopia Planitia Highland Lowland Transitional Zone: Final Technical Approach and Scientific Results; Geology of Libya Montes and the Interbasin Plains of Northern Tyrrhena Terra, Mars: First Year Results and Second Year Work Plan; Mars Global Geologic Mapping Progress and Suggested Geographic-Based Hierarchal Systems for Unit Grouping and Naming; Progress in the Scandia Region Geologic Map of Mars; Geomorphic Mapping of MTMS -20022 and -20017; Geologic Mapping of the Medusae Fossae Formation, Mars, and the Northern Lowland Plains, Venus; Volcanism on Io: Results from Global Geologic Mapping; Employing Geodatabases for Planetary Mapping Conduct - Requirements, Concepts and Solutions; and Planetary Geologic Mapping Handbook - 2010.

Development of Maps of Simple and Complex Cells in the Primary Visual Cortex

PubMed Central

Antolík, Ján; Bednar, James A.

2011-01-01

Hubel and Wiesel (1962) classified primary visual cortex (V1) neurons as either simple, with responses modulated by the spatial phase of a sine grating, or complex, i.e., largely phase invariant. Much progress has been made in understanding how simple-cells develop, and there are now detailed computational models establishing how they can form topographic maps ordered by orientation preference. There are also models of how complex cells can develop using outputs from simple cells with different phase preferences, but no model of how a topographic orientation map of complex cells could be formed based on the actual connectivity patterns found in V1. Addressing this question is important, because the majority of existing developmental models of simple-cell maps group neurons selective to similar spatial phases together, which is contrary to experimental evidence, and makes it difficult to construct complex cells. Overcoming this limitation is not trivial, because mechanisms responsible for map development drive receptive fields (RF) of nearby neurons to be highly correlated, while co-oriented RFs of opposite phases are anti-correlated. In this work, we model V1 as two topographically organized sheets representing cortical layer 4 and 2/3. Only layer 4 receives direct thalamic input. Both sheets are connected with narrow feed-forward and feedback connectivity. Only layer 2/3 contains strong long-range lateral connectivity, in line with current anatomical findings. Initially all weights in the model are random, and each is modified via a Hebbian learning rule. The model develops smooth, matching, orientation preference maps in both sheets. Layer 4 units become simple cells, with phase preference arranged randomly, while those in layer 2/3 are primarily complex cells. To our knowledge this model is the first explaining how simple cells can develop with random phase preference, and how maps of complex cells can develop, using only realistic patterns of connectivity. PMID:21559067

Deletion of tumor progression locus 2 attenuates alcohol induced hepatic inflammation

USDA-ARS?s Scientific Manuscript database

BACKGROUND: The pathogenesis of alcoholic liver disease (ALD) involves the interaction of several inflammatory signaling pathways. Tumor progression locus 2 (TPL2), also known as Cancer Osaka Thyroid (COT) and MAP3K8, is a serine threonine kinase that functions as a critical regulator of inflammator...

Interactome Mapping Guided by Tissue-Specific Phosphorylation in Age-Related Macular Degeneration

PubMed Central

Sripathi, Srinivas R.; He, Weilue; Prigge, Cameron L.; Sylvester, O’Donnell; Um, Ji-Yeon; Powell, Folami L.; Neksumi, Musa; Bernstein, Paul S.; Choo, Dong-Won; Bartoli, Manuela; Gutsaeva, Diana R.; Jahng, Wan Jin

2017-01-01

The current study aims to determine the molecular mechanisms of age-related macular degeneration (AMD) using the phosphorylation network. Specifically, we examined novel biomarkers for oxidative stress by protein interaction mapping using in vitro and in vivo models that mimic the complex and progressive characteristics of AMD. We hypothesized that the early apoptotic reactions could be initiated by protein phosphorylation in region-dependent (peripheral retina vs. macular) and tissue-dependent (retinal pigment epithelium vs. retina) manner under chronic oxidative stress. The analysis of protein interactome and oxidative biomarkers showed the presence of tissue- and region-specific post-translational mechanisms that contribute to AMD progression and suggested new therapeutic targets that include ubiquitin, erythropoietin, vitronectin, MMP2, crystalline, nitric oxide, and prohibitin. Phosphorylation of specific target proteins in RPE cells is a central regulatory mechanism as a survival tool under chronic oxidative imbalance. The current interactome map demonstrates a positive correlation between oxidative stress-mediated phosphorylation and AMD progression and provides a basis for understanding oxidative stress-induced cytoskeletal changes and the mechanism of aggregate formation induced by protein phosphorylation. This information could provide an effective therapeutic approach to treat age-related neurodegeneration. PMID:28580316

Interactome Mapping Guided by Tissue-Specific Phosphorylation in Age-Related Macular Degeneration.

PubMed

Sripathi, Srinivas R; He, Weilue; Prigge, Cameron L; Sylvester, O'Donnell; Um, Ji-Yeon; Powell, Folami L; Neksumi, Musa; Bernstein, Paul S; Choo, Dong-Won; Bartoli, Manuela; Gutsaeva, Diana R; Jahng, Wan Jin

2017-02-01

The current study aims to determine the molecular mechanisms of age-related macular degeneration (AMD) using the phosphorylation network. Specifically, we examined novel biomarkers for oxidative stress by protein interaction mapping using in vitro and in vivo models that mimic the complex and progressive characteristics of AMD. We hypothesized that the early apoptotic reactions could be initiated by protein phosphorylation in region-dependent (peripheral retina vs. macular) and tissue-dependent (retinal pigment epithelium vs. retina) manner under chronic oxidative stress. The analysis of protein interactome and oxidative biomarkers showed the presence of tissue- and region-specific post-translational mechanisms that contribute to AMD progression and suggested new therapeutic targets that include ubiquitin, erythropoietin, vitronectin, MMP2, crystalline, nitric oxide, and prohibitin. Phosphorylation of specific target proteins in RPE cells is a central regulatory mechanism as a survival tool under chronic oxidative imbalance. The current interactome map demonstrates a positive correlation between oxidative stress-mediated phosphorylation and AMD progression and provides a basis for understanding oxidative stress-induced cytoskeletal changes and the mechanism of aggregate formation induced by protein phosphorylation. This information could provide an effective therapeutic approach to treat age-related neurodegeneration.

Comparison of flank modification on Ascraeus and Arsia Montes volcanoes, Mars

NASA Technical Reports Server (NTRS)

Zimbelman, James R.

1993-01-01

Geologic mapping of the Tharsis Montes on Mars is in progress as part of the Mars Geologic Mapping Program of NASA. Mapping of the southern flanks of Ascraeus Mons at 1:500,000 scale was undertaken first followed by detailed mapping of Arsia Mons; mapping of Pavonis Mons will begin later this year. Results indicate that each of the Tharsis volcanoes displays unique variations on the general 'theme' of a martian shield volcano. Here we concentrate on the flank characteristics on Ascraeus Mons and Arsia Mons, the northernmost and southernmost of the Tharsis Montes, as illustrative of the most prominent trends.

The Role of Heat in the Development of Energy and Mineral Resources in the Northern Basin and Range Province

NASA Astrophysics Data System (ADS)

Armstrong, Richard L.

It is now just over a decade since OPEC escalated the price of oil and triggered a flurry of alternate energy research and changing energy consumption practices. One scientific impact of that historical economic turning point was the launching of geothermal exploration programs of unprecedented intensity that focused on Cenozoic volcanic rocks and active, as well as fossil, geothermal systems. The good science that was already being done on such rocks and systems was both accelerated and diluted by government-funded research and energy industry exploration efforts. After the initial flood of detailed reports, gray literature, and documents interred in company files, we are observing the appearance of syntheses of just what happened and what progress was achieved during the geothermal boom (which has now wilted to the quiet development of a few most promising sites). Recent examples of geothermal synthesis literature include the book Geothermal Systems by L. Rybach and L.J. Muffler (John Wiley, New York, 1981), publications like Oregon Department of Geology and Mineral Industries Paper 15 by G.R. Priest et al. (1983) entitled “Geology and geothermal resources of central Oregon Cascade range,” and informative maps like the U.S. Geological Survey series summarizing late Cenozoic volcanic rock distribution and age (R.G. Luedke and R.L. Smith, maps 1-1091 A to D, 1979 to 1982), and state and regional geothermal resources maps (NOAA National Geophysical Data Center, 1977-1982). The book under review here is part of this second literature wave, a useful primary reference, collection of syntheses, and literature guide but certainly not unique.

A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy

PubMed Central

Wang, Jiahui; Fan, Zheng; Vandenborne, Krista; Walter, Glenn; Shiloh-Malawsky, Yael; An, Hongyu; Kornegay, Joe N.; Styner, Martin A.

2015-01-01

Purpose Golden retriever muscular dystrophy (GRMD) is a widely used canine model of Duchenne muscular dystrophy (DMD). Recent studies have shown that magnetic resonance imaging (MRI) can be used to non-invasively detect consistent changes in both DMD and GRMD. In this paper, we propose a semi-automated system to quantify MRI biomarkers of GRMD. Methods Our system was applied to a database of 45 MRI scans from 8 normal and 10 GRMD dogs in a longitudinal natural history study. We first segmented six proximal pelvic limb muscles using two competing schemes: 1) standard, limited muscle range segmentation and 2) semi-automatic full muscle segmentation. We then performed pre-processing, including: intensity inhomogeneity correction, spatial registration of different image sequences, intensity calibration of T2-weighted (T2w) and T2-weighted fat suppressed (T2fs) images, and calculation of MRI biomarker maps. Finally, for each of the segmented muscles, we automatically measured MRI biomarkers of muscle volume and intensity statistics over MRI biomarker maps, and statistical image texture features. Results The muscle volume and the mean intensities in T2 value, fat, and water maps showed group differences between normal and GRMD dogs. For the statistical texture biomarkers, both the histogram and run-length matrix features showed obvious group differences between normal and GRMD dogs. The full muscle segmentation shows significantly less error and variability in the proposed biomarkers when compared to the standard, limited muscle range segmentation. Conclusion The experimental results demonstrated that this quantification tool can reliably quantify MRI biomarkers in GRMD dogs, suggesting that it would also be useful for quantifying disease progression and measuring therapeutic effect in DMD patients. PMID:23299128

Should patients with self-inflicted illness receive lower priority in access to healthcare resources? Mapping out the debate.

PubMed

Sharkey, Kerith; Gillam, Lynn

2010-11-01

The distribution of scarce healthcare resources is an increasingly important issue due to factors such as expensive 'high tech' medicine, longer life expectancies and the rising prevalence of chronic illness. Furthermore, in the current healthcare context lifestyle-related factors such as high blood pressure, tobacco use and obesity are believed to contribute significantly to the global burden of disease. As such, this paper focuses on an ongoing debate in the academic literature regarding the role of responsibility for illness in healthcare resource allocation: should patients with self-caused illness receive lower priority in access to healthcare resources? This paper critically describes the lower priority debate's 12 key arguments and maps out their relationships. This analysis reveals that most arguments have been refuted and that the debate has stalled and remains unresolved. In conclusion, we suggest progression could be achieved by inviting multidisciplinary input from a range of stakeholders for the development of evidence-based critical evaluations of existing arguments and the development of novel arguments, including the outstanding rebuttals.

Integrating common and rare genetic variation in diverse human populations.

PubMed

Altshuler, David M; Gibbs, Richard A; Peltonen, Leena; Altshuler, David M; Gibbs, Richard A; Peltonen, Leena; Dermitzakis, Emmanouil; Schaffner, Stephen F; Yu, Fuli; Peltonen, Leena; Dermitzakis, Emmanouil; Bonnen, Penelope E; Altshuler, David M; Gibbs, Richard A; de Bakker, Paul I W; Deloukas, Panos; Gabriel, Stacey B; Gwilliam, Rhian; Hunt, Sarah; Inouye, Michael; Jia, Xiaoming; Palotie, Aarno; Parkin, Melissa; Whittaker, Pamela; Yu, Fuli; Chang, Kyle; Hawes, Alicia; Lewis, Lora R; Ren, Yanru; Wheeler, David; Gibbs, Richard A; Muzny, Donna Marie; Barnes, Chris; Darvishi, Katayoon; Hurles, Matthew; Korn, Joshua M; Kristiansson, Kati; Lee, Charles; McCarrol, Steven A; Nemesh, James; Dermitzakis, Emmanouil; Keinan, Alon; Montgomery, Stephen B; Pollack, Samuela; Price, Alkes L; Soranzo, Nicole; Bonnen, Penelope E; Gibbs, Richard A; Gonzaga-Jauregui, Claudia; Keinan, Alon; Price, Alkes L; Yu, Fuli; Anttila, Verneri; Brodeur, Wendy; Daly, Mark J; Leslie, Stephen; McVean, Gil; Moutsianas, Loukas; Nguyen, Huy; Schaffner, Stephen F; Zhang, Qingrun; Ghori, Mohammed J R; McGinnis, Ralph; McLaren, William; Pollack, Samuela; Price, Alkes L; Schaffner, Stephen F; Takeuchi, Fumihiko; Grossman, Sharon R; Shlyakhter, Ilya; Hostetter, Elizabeth B; Sabeti, Pardis C; Adebamowo, Clement A; Foster, Morris W; Gordon, Deborah R; Licinio, Julio; Manca, Maria Cristina; Marshall, Patricia A; Matsuda, Ichiro; Ngare, Duncan; Wang, Vivian Ota; Reddy, Deepa; Rotimi, Charles N; Royal, Charmaine D; Sharp, Richard R; Zeng, Changqing; Brooks, Lisa D; McEwen, Jean E

2010-09-02

Despite great progress in identifying genetic variants that influence human disease, most inherited risk remains unexplained. A more complete understanding requires genome-wide studies that fully examine less common alleles in populations with a wide range of ancestry. To inform the design and interpretation of such studies, we genotyped 1.6 million common single nucleotide polymorphisms (SNPs) in 1,184 reference individuals from 11 global populations, and sequenced ten 100-kilobase regions in 692 of these individuals. This integrated data set of common and rare alleles, called 'HapMap 3', includes both SNPs and copy number polymorphisms (CNPs). We characterized population-specific differences among low-frequency variants, measured the improvement in imputation accuracy afforded by the larger reference panel, especially in imputing SNPs with a minor allele frequency of

Molecular mapping of chromosomes 17 and X. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barker, D.F.

1991-01-15

Progress toward the construction of high density genetic maps of chromosomes 17 and X has been made by isolating and characterizing a relatively large set of polymorphic probes for each chromosome and using these probes to construct genetic maps. We have mapped the same polymorphic probes against a series of chromosome breakpoints on X and 17. The probes could be assigned to over 30 physical intervals on the X chromosome and 7 intervals on 17. In many cases, this process resulted in improved characterization of the relative locations of the breakpoints with respect to each other and the definition ofmore » new physical intervals. The strategy for isolation of the polymorphic clones utilized chromosome specific libraries of 1--15 kb segments from each of the two chromosomes. From these libraries, clones were screened for those detecting restriction fragment length polymorphisms. The markers were further characterized, the chromosomal assignments confirmed and in most cases segments of the original probes were subcloned into plasmids to produce probes with improved signal to noise ratios for use in the genetic marker studies. The linkage studies utilize the CEPH reference families and other well-characterized families in our collection which have been used for genetic disease linkage work. Preliminary maps and maps of portions of specific regions of 17 and X are provided. We have nearly completed a map of the 1 megabase Mycoplasma arthritidis genome by applying these techniques to a lambda phage library of its genome. We have found bit mapping to be an efficient means to organize a contiguous set of overlapping@ clones from a larger genome.« less

Prismatic displacement effect of progressive multifocal glasses on reaction time and accuracy in elderly people

PubMed Central

Ellison, Ashton C; Campbell, A John; Robertson, M Clare; Sanderson, Gordon F

2014-01-01

Background Multifocal glasses (bifocals, trifocals, and progressives) increase the risk of falling in elderly people, but how they do so is unclear. To explain why glasses with progressive addition lenses increase the risk of falls and whether this can be attributed to false projection, this study aimed to 1) map the prismatic displacement of a progressive lens, and 2) test whether this displacement impaired reaction time and accuracy. Methods The reaction times of healthy ≥75-year-olds (31 participants) were measured when grasping for a bar and touching a black line. Participants performed each test twice, wearing their progressives and new, matched single vision (distance) glasses in random order. The line and bar targets were positioned according to the maximum and minimum prismatic displacement effect through the progressive lens, mapped using a focimeter. Results Progressive spectacle lenses have large areas of prismatic displacement in the central visual axis and edges. Reaction time was faster for progressives compared with single vision glasses with a centrally-placed horizontal grab bar (mean difference 101 ms, P=0.011 [repeated measures analysis]) and a horizontal black line placed 300 mm below center (mean difference 80 ms, P=0.007). There was no difference in accuracy between the two types of glasses. Conclusion Older people appear to adapt to the false projection of progressives in the central visual axis. This adaptation means that swapping to new glasses or a large change in prescription may lead to a fall. Frequently updating glasses may be more beneficial. PMID:24872674

78 FR 60755 - Hazardous Materials: Enhanced Enforcement Procedures-Resumption of Transportation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

.... Summary of MAP-21 and Final Rule V. Summary Review of Amendments VI. Regulatory Analyses and Notices A.... Executive Summary On July 6, 2012, the President signed the Moving Ahead for Progress in the 21st Century Act, or the MAP-21, which included the Hazardous Materials Transportation Safety Improvement Act of...

Linking the Kentucky K-PREP Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the Kansas KAP Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the PARCC Assessments to NWEA MAP Tests for Illinois

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the Texas STAAR Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the Nebraska NeSA Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the Alaska AMP Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the PARCC Assessments to NWEA MAP Tests for New Mexico

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Linking the Arizona AZMERIT Assessments to NWEA MAP Tests

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

Metateaching and the Instructional Map. Teaching Techniques/Strategies Series, Volume 1.

ERIC Educational Resources Information Center

Timpson, William M.

This book describes a conceptual framework, the "Instructional Map"--a metaphor for envisioning the interconnectedness of teacher and student, teaching and learning, and content and process--that can help teachers plan, sort their way through course material and instructional options, interact with students, and reflect upon progress made and what…

MAP Science for Use with Next Generation Science Standards. NWEA External FAQ

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2016

2016-01-01

Measures of Academic Progress® (MAP®) Science for use with Next Generation Science Standards (NGSS) assessments are available for the 2016-17 school year. These new assessments measure student growth toward understanding of the multidimensional NGSS performance expectations. This report presents MAP Science for use with NGSS by presenting and…

Neighborhoods in Development: Human Development Index and Self-Organizing Maps

ERIC Educational Resources Information Center

Rende, Sevinc; Donduran, Murat

2013-01-01

The Human Development Index (HDI) has been instrumental in broadening the discussion of economic development beyond money-metric progress, in particular, by ranking a country against other countries in terms of the well being of their citizens. We propose self-organizing maps to explore similarities among countries using the components of the HDI…

Variable-Speed Power-Turbine Research at Glenn Research Center

NASA Technical Reports Server (NTRS)

Welch, Gerard E.; McVetta, Ashlie B.; Stevens, Mark A.; Howard, Samuel A.; Giel, Paul W.; Ameri, Ali, A.; To, Waiming; Skoch, Gary J.; Thurman, Douglas R.

2012-01-01

The main rotors of the NASA Large Civil Tilt-Rotor (LCTR) notional vehicle operate over a wide speed-range, from 100 percent at takeoff to 54 percent at cruise. The variable-speed power turbine (VSPT) offers one approach by which to effect this speed variation. VSPT aerodynamics challenges include high work factors at cruise, wide (40 to 60 ) incidence-angle variations in blade and vane rows over the speed range, and operation at low Reynolds numbers. Rotordynamics challenges include potential responsiveness to shaft modes within the 50 percent VSPT speed-range. A research effort underway at NASA Glenn Research Center, intended to address these key aerodynamic and rotordynamic challenges, is described. Conceptual design and 3-D multistage RANS and URANS analyses, conducted internally and under contract, provide expected VSPT sizing, stage-count, performance and operability information, and maps for system studies. Initial steps toward experimental testing of incidence-tolerant blading in a transonic linear cascade are described, and progress toward development/improvement of a simulation capability for multistage turbines with low Reynolds number transitional flow is summarized. Preliminary rotordynamics analyses indicate that viable concept engines with 50 percent VSPT shaft-speed range. Assessments of potential paths toward VSPT component-level testing are summarized.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hausegger, Sebastian von; Liu, Hao; Sarkar, Subir

Cosmology has made enormous progress through studies of the cosmic microwave background, however the subtle signals being now sought such as B-mode polarisation due to primordial gravitational waves are increasingly hard to disentangle from residual Galactic foregrounds in the derived CMB maps. We revisit our finding that on large angular scales there are traces of the nearby old supernova remnant Loop I in the WMAP 9-year map of the CMB and confirm this with the new SMICA map from the Planck satellite.

Computer generated maps from digital satellite data - A case study in Florida

NASA Technical Reports Server (NTRS)

Arvanitis, L. G.; Reich, R. M.; Newburne, R.

1981-01-01

Ground cover maps are important tools to a wide array of users. Over the past three decades, much progress has been made in supplementing planimetric and topographic maps with ground cover details obtained from aerial photographs. The present investigation evaluates the feasibility of using computer maps of ground cover from satellite input tapes. Attention is given to the selection of test sites, a satellite data processing system, a multispectral image analyzer, general purpose computer-generated maps, the preliminary evaluation of computer maps, a test for areal correspondence, the preparation of overlays and acreage estimation of land cover types on the Landsat computer maps. There is every indication to suggest that digital multispectral image processing systems based on Landsat input data will play an increasingly important role in pattern recognition and mapping land cover in the years to come.

Ensuring the security of synthetic biology-towards a 5P governance strategy.

PubMed

Kelle, Alexander

2009-12-01

Over recent years the label "synthetic biology" has been attached to a number of diverse research and commercial activities, ranging from the search for a minimal cell to the quick delivery of customized genes by DNA synthesis companies. Based on the analysis of biosecurity issues surrounding synthetic biology during the SYNBIOSAFE project, this paper will first provide a rationale for taking security, in addition to safety aspects of this new field, seriously. It will then take stock of the initiatives and measures that have already been taken in this area and will lastly try to map out future areas of activities in order to minimise the security risks emanating from this promising new field of scientific inquiry and technological progress.

Is there a Stobbs factor in atomic-resolution STEM-EELS mapping?

PubMed

Xin, Huolin L; Dwyer, Christian; Muller, David A

2014-04-01

Recent work has convincingly argued that the Stobbs factor-disagreement in contrast between simulated and experimental atomic-resolution images-in ADF-STEM imaging can be accounted for by including the incoherent source size in simulation. However, less progress has been made for atomic-resolution STEM-EELS mapping. Here we have performed carefully calibrated EELS mapping experiments of a [101] DyScO3 single-crystal specimen, allowing atomic-resolution EELS signals to be extracted on an absolute scale for a large range of thicknesses. By simultaneously recording the elastic signal, also on an absolute scale, and using it to characterize the source size, sample thickness and inelastic mean free path, we eliminate all free parameters in the simulation of the core-loss signals. Coupled with double channeling simulations that incorporate both core-loss inelastic scattering and dynamical elastic and thermal diffuse scattering, the present work enables a close scrutiny of the scattering physics in the inelastic channel. We found that by taking into account the effective source distribution determined from the ADF images, both the absolute signal and the contrast in atomic-resolution Dy-M5 maps can be closely reproduced by the double-channeling simulations. At lower energy losses, discrepancies are present in the Sc-L2,3 and Dy-N4,5 maps due to the energy-dependent spatial distribution of the background spectrum, core-hole effects, and omitted complexities in the final states. This work has demonstrated the possibility of using quantitative STEM-EELS for element-specific column-by-column atom counting at higher energy losses and for atomic-like final states, and has elucidated several possible improvements for future theoretical work. Copyright © 2014 Elsevier B.V. All rights reserved.

Transmission and visualization of large geographical maps

NASA Astrophysics Data System (ADS)

Zhang, Liqiang; Zhang, Liang; Ren, Yingchao; Guo, Zhifeng

Transmission and visualization of large geographical maps have become a challenging research issue in GIS applications. This paper presents an efficient and robust way to simplify large geographical maps using frame buffers and Voronoi diagrams. The topological relationships are kept during the simplification by removing the Voronoi diagram's self-overlapped regions. With the simplified vector maps, we establish different levels of detail (LOD) models of these maps. Then we introduce a client/server architecture which integrates our out-of-core algorithm, progressive transmission and rendering scheme based on computer graphics hardware. The architecture allows the viewers to view different regions interactively at different LODs on the network. Experimental results show that our proposed scheme provides an effective way for powerful transmission and manipulation of large maps.

All over the Map: A Progress Report on the State Children's Health Insurance Program (CHIP).

ERIC Educational Resources Information Center

Edmunds, Margo; Teitelbaum, Martha; Gleason, Cassy

The State Children's Health Insurance Program (CHIP) was designed in 1997 to support working families by providing affordable, quality health coverage for their children in an efficient, effective, and coordinated way. This report examines the progress made in implementing CHIP nationwide. Information sources included the following: (1) federal…

Toward mapping crop progress at field scales through fusion of Landsat and MODIS imagery

USDA-ARS?s Scientific Manuscript database

Crop progress and condition are required for crop management and yield estimation. In the United States, they are reported weekly at state or district level by the U.S. Department of Agriculture (USDA) National Agricultural Statistics Service (NASS) using the field observations provided by local far...

Progressive and self-limiting neurodegenerative disorders in Africa: a new prominent field of research led by South Africa but without strong health policy.

PubMed

Poreau, Brice

2016-01-01

Neurodegenerative disorders are involved in mortality and morbidity of every country. A high prevalence is estimated in Africa. Neurodegenerative disorders are defined by a progressive or self-limiting alteration of neurons implied in specific functional and anatomical functions. It encompasses a various range of clinical disorders from self-limiting to progressive. Focus on public health policies and scientific research is needed to understand the mechanisms to reduce this high prevalence. We use bibliometrics and mapping tools to explore the area studies and countries involved in scientific research on neurodegenerative disorders in Africa. We used two databases: Web of Science and Pubmed. We analyzed the journals, most cited articles, authors, publication years, organizations, funding agencies, countries and keywords in Web of Science Core collection database and publication years and Medical Subject Headings in Pubmed database. We mapped the data using VOSviewer. We accessed 44 articles published between 1975 and 2014 in Web of Science Core collection Database and 669 from Pubmed database. The majority of which were after 2006. The main countries involved in research on neurodegenerative disorders in Africa the USA, the United Kingdom, France and South Africa representing the main network collaboration. Clinical neurology and Genetics hereditary are the main Web of Science categories whereas Neurosciences and Biochemistry and Molecular Biology are the main Web of Science categories for the general search "neurodegenerative disorders" not restrained to Africa. This is confirmed by Medical Subject Headings analysis from Pubmed with one more area study: Treatment. Neurodegenerative disorders research is leaded by South Africa with a network involving the USA, the UK, as well as African countries such Zambia. The chief field that emerged was on patient and hereditary as well as treatment. Public health policies were lacking fields in research whereas prevalence is estimated to be important in every country. New 17 sustainable development goals of the United Nations could help in this way.

Serial diffusion-weighted imaging in subacute sclerosing panencephalitis.

PubMed

Kanemura, Hideaki; Aihara, Masao

2008-06-01

Subacute sclerosing panencephalitis may be associated with clinical features of frontal lobe dysfunction. We previously reported that frontal lobe volume falls significantly as clinical stage progresses, using three-dimensional magnetic resonance imaging-based brain volumetry. The hypothesis that frontal volume increases correlate with clinical improvement, however, was not tested in our previous study. Therefore, we reevaluated our patient with subacute sclerosing panencephalitis, to determine whether apparent diffusion coefficient maps can characterize the clinical course of subacute sclerosing panencephalitis. We studied an 8-year-old boy with subacute sclerosing panencephalitis, using serial diffusion-weighted imaging magnetic resonance imaging, and measured the regional apparent diffusion coefficient. The regional apparent diffusion coefficient of the frontal lobe decreased significantly with clinical progression, whereas it increased to within normal range during clinical improvements. The apparent diffusion coefficient of the other regions did not change. These results suggest that the clinical signs of patients with subacute sclerosing panencephalitis are attributable to frontal lobe dysfunction, and that apparent diffusion coefficient measurements may be useful in predicting the clinical course of subacute sclerosing panencephalitis.

Usability Evaluation of Public Web Mapping Sites

NASA Astrophysics Data System (ADS)

Wang, C.

2014-04-01

Web mapping sites are interactive maps that are accessed via Webpages. With the rapid development of Internet and Geographic Information System (GIS) field, public web mapping sites are not foreign to people. Nowadays, people use these web mapping sites for various reasons, in that increasing maps and related map services of web mapping sites are freely available for end users. Thus, increased users of web mapping sites led to more usability studies. Usability Engineering (UE), for instance, is an approach for analyzing and improving the usability of websites through examining and evaluating an interface. In this research, UE method was employed to explore usability problems of four public web mapping sites, analyze the problems quantitatively and provide guidelines for future design based on the test results. Firstly, the development progress for usability studies were described, and simultaneously several usability evaluation methods such as Usability Engineering (UE), User-Centered Design (UCD) and Human-Computer Interaction (HCI) were generally introduced. Then the method and procedure of experiments for the usability test were presented in detail. In this usability evaluation experiment, four public web mapping sites (Google Maps, Bing maps, Mapquest, Yahoo Maps) were chosen as the testing websites. And 42 people, who having different GIS skills (test users or experts), gender (male or female), age and nationality, participated in this test to complete the several test tasks in different teams. The test comprised three parts: a pretest background information questionnaire, several test tasks for quantitative statistics and progress analysis, and a posttest questionnaire. The pretest and posttest questionnaires focused on gaining the verbal explanation of their actions qualitatively. And the design for test tasks targeted at gathering quantitative data for the errors and problems of the websites. Then, the results mainly from the test part were analyzed. The success rate from different public web mapping sites was calculated and compared, and displayed by the means of diagram. And the answers from questionnaires were also classified and organized in this part. Moreover, based on the analysis, this paper expands the discussion about the layout, map visualization, map tools, search logic and etc. Finally, this paper closed with some valuable guidelines and suggestions for the design of public web mapping sites. Also, limitations for this research stated in the end.

Cat-Map: putting cataract on the map

PubMed Central

Bennett, Thomas M.; Hejtmancik, J. Fielding

2010-01-01

Lens opacities, or cataract(s), may be inherited as a classic Mendelian disorder usually with early-onset or, more commonly, acquired with age as a multi-factorial or complex trait. Many genetic forms of cataract have been described in mice and other animal models. Considerable progress has been made in mapping and identifying the genes and mutations responsible for inherited forms of cataract, and genetic determinants of age-related cataract are beginning to be discovered. To provide a convenient and accurate summary of current information focused on the increasing genetic complexity of Mendelian and age-related cataract we have created an online chromosome map and reference database for cataract in humans and mice (Cat-Map). PMID:21042563

78 FR 22798 - Hazardous Materials: Revision of Maximum and Minimum Civil Penalties

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... ``Moving Ahead for Progress in the 21st Century Act'' (MAP-21), effective October 1, 2012, the maximum..., DC 20590-0001. SUPPLEMENTARY INFORMATION: I. Civil Penalty Amendments In Section 33010 of MAP-21 (Pub... Safety Administration. [FR Doc. 2013-08981 Filed 4-16-13; 8:45 am] BILLING CODE 4910-60-P ...

Implementation of Concept Mapping to Novices: Reasons for Errors, a Matter of Technique or Content?

ERIC Educational Resources Information Center

Conradty, Catherine; Bogner, Franz X.

2010-01-01

Concept mapping is discussed as a means to promote meaningful learning and in particular progress in reading comprehension skills. Its increasing implementation necessitates the acquisition of adequate knowledge about frequent errors in order to make available an effective introduction to the new learning method. To analyse causes of errors, 283…

Empirically Guided Coordination of Multiple Evidence-Based Treatments: An Illustration of Relevance Mapping in Children's Mental Health Services

ERIC Educational Resources Information Center

Chorpita, Bruce F.; Bernstein, Adam; Daleiden, Eric L.

2011-01-01

Objective: Despite substantial progress in the development and identification of psychosocial evidence-based treatments (EBTs) in mental health, there is minimal empirical guidance for selecting an optimal "set" of EBTs maximally applicable and generalizable to a chosen service sample. Relevance mapping is a proposed methodology that…

The Effect of Flexible Small Groups on Math Achievement in First Grade

ERIC Educational Resources Information Center

Benders, David; Craft, Tracy

2016-01-01

This action research study explores the Guided Math Approach to improving math scores for first grade students. Previous MAP (Measure of Academic Progress) scores were used to measure proficiency and students were placed in separate categories for appropriate instruction. This study reviewed math achievement scores on MAP test from a First grade…

Linking PARCC and MAP Assessments for Students in Montgomery County Public Schools. Applied Research

ERIC Educational Resources Information Center

Wang, Helen Y.; Zhao, Huafang; Addison, Kecia L.

2016-01-01

The Office of Shared Accountability (OSA) in Montgomery County Public Schools (MCPS) conducted a linking study to examine the relationship of the Measures of Academic Progress (MAP) assessment with the Common Core Consortia Partnership for Assessment of Readiness for College and Careers (PARCC) assessment in the 2014-2015 school year. This is the…

Construction of a Genetic Linkage Map and Identification of QTLs for Resistance to TSWV in Cultivated Peanut (Arachis hypagea L.)

USDA-ARS?s Scientific Manuscript database

A genetic linkage map is critical for identifying the QTL (quantitative trait loci) underling targeted traits. Over the last few years, progress has been made in marker development from multiple sources enabling the expansion of quality resources needed for genotyping applications in cultivated x cu...

Color reproduction system based on color appearance model and gamut mapping

NASA Astrophysics Data System (ADS)

Cheng, Fang-Hsuan; Yang, Chih-Yuan

2000-06-01

By the progress of computer, computer peripherals such as color monitor and printer are often used to generate color image. However, cross media color reproduction by human perception is usually different. Basically, the influence factors are device calibration and characterization, viewing condition, device gamut and human psychology. In this thesis, a color reproduction system based on color appearance model and gamut mapping is proposed. It consists of four parts; device characterization, color management technique, color appearance model and gamut mapping.

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

DOE PAGES

Barad, Benjamin A.; Echols, Nathaniel; Wang, Ray Yu-Ruei; ...

2015-08-17

Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of validation metrics to independently assess map quality and model geometry. We report that EMRinger is a tool that assesses the precise fitting of an atomic model into the map during refinement and shows how radiation damage alters scattering from negatively charged amino acids. EMRinger (https://github.com/fraser-lab/EMRinger) will be useful for monitoring progress in resolving and modeling high-resolution features in cryo-EM.

A close-range photogrammetric technique for mapping neotectonic features in trenches

USGS Publications Warehouse

Fairer, G.M.; Whitney, J.W.; Coe, J.A.

1989-01-01

Close-range photogrammetric techniques and newly available computerized plotting equipment were used to map exploratory trench walls that expose Quaternary faults in the vicinity of Yucca Mountain, Nevada. Small-scale structural, lithologic, and stratigraphic features can be rapidly mapped by the photogrammetric method. This method is more accurate and significantly more rapid than conventional trench-mapping methods, and the analytical plotter is capable of producing cartographic definition of high resolution when detailed trench maps are necessary. -from Authors

Averaged kick maps: less noise, more signal…and probably less bias

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pražnikar, Jure; Afonine, Pavel V.; Gunčar, Gregor

2009-09-01

Averaged kick maps are the sum of a series of individual kick maps, where each map is calculated from atomic coordinates modified by random shifts. These maps offer the possibility of an improved and less model-biased map interpretation. Use of reliable density maps is crucial for rapid and successful crystal structure determination. Here, the averaged kick (AK) map approach is investigated, its application is generalized and it is compared with other map-calculation methods. AK maps are the sum of a series of kick maps, where each kick map is calculated from atomic coordinates modified by random shifts. As such, theymore » are a numerical analogue of maximum-likelihood maps. AK maps can be unweighted or maximum-likelihood (σ{sub A}) weighted. Analysis shows that they are comparable and correspond better to the final model than σ{sub A} and simulated-annealing maps. The AK maps were challenged by a difficult structure-validation case, in which they were able to clarify the problematic region in the density without the need for model rebuilding. The conclusion is that AK maps can be useful throughout the entire progress of crystal structure determination, offering the possibility of improved map interpretation.« less

Citizen-Scientist Digitization of a Complex Geologic Map of the McDowell Mountains (Scottsdale, Arizona).

NASA Astrophysics Data System (ADS)

Gruber, D.; Skotnicki, S.; Gootee, B.

2016-12-01

The work of citizen scientists has become very important to researchers doing field work and internet-based projects but has not been widely utilized in digital mapping. The McDowell Mountains - located in Scottsdale, Arizona, at the edge of the basin-and-range province and protected as part of the McDowell Sonoran Preserve - are geologically complex. Until recently, no comprehensive geologic survey of the entire range had been done. Over the last 9 years geologist Steven Skotnicki spent 2000 hours mapping the complex geology of the range. His work, born of personal interest and partially supported by the McDowell Sonoran Conservancy, resulted in highly detailed hand-drawn survey maps. Dr. Skotnicki's work provides important new information and raises interesting research questions about the geology of this range. Citizen scientists of the McDowell Sonoran Conservancy Field Institute digitized Dr. Skotnicki's maps. A team of 10 volunteers, trained in ArcMap digitization techniques and led by volunteer project leader Daniel Gruber, performed the digitization work. Technical oversight of mapping using ArcMap, including provision of USGS-based mapping toolbars, was provided by Arizona Geological Survey (AZGS) research geologist Brian Gootee. The map digitization process identified and helped resolve a number of mapping questions. The citizen-scientist team spent 900 hours on training, digitization, quality checking, and project coordination with support and review by Skotnicki and Gootee. The resulting digital map has approximately 3000 polygons, 3000 points, and 86 map units with complete metadata and unit descriptions. The finished map is available online through AZGS and can be accessed in the field on mobile devices. User location is shown on the map and metadata can be viewed with a tap. The citizen scientist map digitization team has made this important geologic information available to the public and accessible to other researchers quickly and efficiently.

Construction of Improved Maps of Mercury's Crustal Magnetic Field at Northern Midlatitudes

NASA Astrophysics Data System (ADS)

Hood, L. L.; Oliveira, J. S.

2017-12-01

We report progress toward the construction of a refined version of the northern midlatitude crustal magnetic field map of Hood [GRL, 2016], extended to cover latitudes from 35N to 80N and all longitudes. The main improvements include: (1) Combining MESSENGER magnetometer data from August and September of 2014 with that from February, March, and April of 2015 to provide the best overall input data set for mapping and the largest possible area of coverage; (2) improving the elimination of external and core field contamination by using a model for Mercury's core field and a more conservative high-pass filter length; and (3) improving the equivalent source dipole (ESD) mapping technique using an equidistant equivalent source dipole array and varying the depth, orientation, and resolution of the array to minimize the overall root mean square misfit. Combining data from the two time intervals allows the total latitude range of the final map to be increased by at least 5 degrees to 35N - 80N. Also, previous mapping has concentrated on the hemisphere from 90E to 270E; inclusion of all available data will allow the final maps to be extended to all longitudes, more than doubling the coverage reported by Hood [2016]. Previous work has demonstrated a concentration of relatively strong magnetic anomalies near and within the Caloris impact basin. A secondary concentration near Sobkou Planitia, which contains an older impact basin, was also found. The existence of anomalies within the Caloris rim implies that a steady magnetizing field, i.e., a core dynamo, was present when this basin formed. A major application of the improved map will be to investigate whether anomalies are concentrated near and within other impact basins. If some basins are found not to have concentrations of magnetic anomalies, this could imply a role of impactor composition (e.g., iron content) in producing the crustal materials that are most strongly magnetized, as has previously been proposed to be the case on the Moon [Wieczorek et al., Science, 2012].

Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations.

PubMed

Rickards, Caroline A; Sprick, Justin D; Colby, Hannah B; Kay, Victoria L; Tzeng, Yu-Chieh

2015-04-01

We tested the hypothesis that transmission of arterial pressure to brain tissue oxygenation is low under conditions of arterial pressure instability. Two experimental models of hemodynamic instability were used in healthy human volunteers; (1) oscillatory lower body negative pressure (OLBNP) (N = 8; 5 male, 3 female), and; (2) maximal LBNP to presyncope (N = 21; 13 male, 8 female). Mean arterial pressure (MAP), middle cerebral artery velocity (MCAv), and cerebral tissue oxygen saturation (ScO2) were measured non-invasively. For the OLBNP protocol, between 0 and -60 mmHg negative pressure was applied for 20 cycles at 0.05 Hz, then 20 cycles at 0.1 Hz. For the maximal LBNP protocol, progressive 5 min stages of chamber decompression were applied until the onset of presyncope. Spectral power of MAP, mean MCAv, and ScO2 were calculated within the VLF (0.04-0.07 Hz), and LF (0.07-0.2 Hz) ranges, and cross-spectral coherence was calculated for MAP-mean MCAv, MAP-ScO2, and mean MCAv-ScO2 at baseline, during each OLBNP protocol, and at the level prior to pre-syncope during maximal LBNP (sub-max). The key findings are (1) both 0.1 Hz OLBNP and sub-max LBNP elicited increases in LF power for MAP, mean MCAv, and ScO2 (p ≤ 0.08); (2) 0.05 Hz OLBNP increased VLF power in MAP and ScO2 only (p ≤ 0.06); (3) coherence between MAP-mean MCAv was consistently higher (≥0.71) compared with MAP-ScO2, and mean MCAv-ScO2 (≤0.43) during both OLBNP protocols, and sub-max LBNP (p ≤ 0.04). These data indicate high linearity between pressure and cerebral blood flow variations, but reduced linearity between cerebral tissue oxygenation and both arterial pressure and cerebral blood flow. Measuring arterial pressure variability may not always provide adequate information about the downstream effects on cerebral tissue oxygenation, the key end-point of interest for neuronal viability.

The Irish Seabed Mapping Programme: INFOMAR - Integrated Mapping Survey for the Sustainable Developments of Ireland's Marine Resources. Progress to Date.

NASA Astrophysics Data System (ADS)

Sacchetti, F.; Benetti, S.; Fitzpatrick, F.

2006-12-01

During the last six years, the Geological Survey of Ireland and the Marine Institute of Ireland worked together on the multimillion Irish National Seabed Survey project with the purpose of mapping the Irish marine territory using a suite of remote sensing equipment, from multibeam to seismic, achieving 87% coverage of the marine zone. Ireland was the first country in the world to carry out an extensive mapping project of their extended Exclusive Economic Zone. The Irish National Seabed Survey is now succeeded by the multiyear INFOMAR Programme. INFOMAR will concentrate initially on mapping twenty-six selected priority bays, three sea areas and the fisheries-protection "Biologically Sensitive Area", and then will complete 100% mapping of the remainder of the EEZ. Designed to incorporate all elements of an integrated mapping programme, the key data acquisition will include hydrography, oceanographic, geological and heritage data. These data sets discharge Ireland's obligations under international treaties to which she is signatory and the uses of these data are vast and multipurpose: from management plans for inshore fishing, aquaculture, coastal protection and engineering works, to environmental impact assessments related to licensing activity and support to the evolving needs of integrated coastal zone management. INFOMAR also includes a data management, exchange and integration programme for the establishment of a National Marine Data Discovery and Exchange Service; providing improved dissemination of information to researchers, policy makers, the public and private sector and the adoption of standard operating procedures in data management to facilitate inter-agency data integration. During the first year of activity, INFOMAR carried out an integrated survey from the national research vessel, the RV Celtic Explorer, acquiring hydrographic, geophysical and groundtruthing data from Bantry and Dunmanus Bays, located off the South West coast of Ireland. Airborne LiDAR (Light Detection And Ranging) and small-vessel mapping surveys have also been carried out, giving detailed bathymetric, topographic and habitat information for the shoaler waters and inshore areas. This presentation will focus both on the general framework and scope of INFOMAR and the initial results and experiences of this year's survey.

Forest and range mapping in the Houston area with ERTS-1

NASA Technical Reports Server (NTRS)

Heath, G. R.; Parker, H. D.

1973-01-01

ERTS-1 data acquired over the Houston area has been analyzed for applications to forest and range mapping. In the field of forestry the Sam Houston National Forest (Texas) was chosen as a test site, (Scene ID 1037-16244). Conventional imagery interpretation as well as computer processing methods were used to make classification maps of timber species, condition and land-use. The results were compared with timber stand maps which were obtained from aircraft imagery and checked in the field. The preliminary investigations show that conventional interpretation techniques indicated an accuracy in classification of 63 percent. The computer-aided interpretations made by a clustering technique gave 70 percent accuracy. Computer-aided and conventional multispectral analysis techniques were applied to range vegetation type mapping in the gulf coast marsh. Two species of salt marsh grasses were mapped.

Airborne laser swath mapping of the Denton Hills, Transantarctic Mountains, Antarctica: Applications for structural and glacial geomorphic mapping

USGS Publications Warehouse

Wilson, Terry; Csathó, Beata

2007-01-01

High-resolution digital elevation data acquired by airborne laser scanning (ALS) for the Denton Hills, along the coastal foothills of the Royal Society Range, Transantarctic Mountains, are examined for applications to bedrock and glacial geomorphic mapping. Digital elevation models (DEMs), displayed as shaded-relief images and slope maps, portray geomorphic landscape features in unprecedented detail across the region. Structures of both ductile and brittle origin, ranging in age from the Paleozoic to the Quaternary, can be mapped from the DEMs. Glacial features, providing a record of the limits of grounded ice, of lake paleoshorelines, and of proglacial lake-ice conveyor deposits, are also prominent on the DEMs. The ALS-derived topographic data have great potential for a range of mapping applications in regions of ice-free terrain in Antarctica

A tone mapping operator based on neural and psychophysical models of visual perception

NASA Astrophysics Data System (ADS)

Cyriac, Praveen; Bertalmio, Marcelo; Kane, David; Vazquez-Corral, Javier

2015-03-01

High dynamic range imaging techniques involve capturing and storing real world radiance values that span many orders of magnitude. However, common display devices can usually reproduce intensity ranges only up to two to three orders of magnitude. Therefore, in order to display a high dynamic range image on a low dynamic range screen, the dynamic range of the image needs to be compressed without losing details or introducing artefacts, and this process is called tone mapping. A good tone mapping operator must be able to produce a low dynamic range image that matches as much as possible the perception of the real world scene. We propose a two stage tone mapping approach, in which the first stage is a global method for range compression based on a gamma curve that equalizes the lightness histogram the best, and the second stage performs local contrast enhancement and color induction using neural activity models for the visual cortex.

Automated detection of extended sources in radio maps: progress from the SCORPIO survey

NASA Astrophysics Data System (ADS)

Riggi, S.; Ingallinera, A.; Leto, P.; Cavallaro, F.; Bufano, F.; Schillirò, F.; Trigilio, C.; Umana, G.; Buemi, C. S.; Norris, R. P.

2016-08-01

Automated source extraction and parametrization represents a crucial challenge for the next-generation radio interferometer surveys, such as those performed with the Square Kilometre Array (SKA) and its precursors. In this paper, we present a new algorithm, called CAESAR (Compact And Extended Source Automated Recognition), to detect and parametrize extended sources in radio interferometric maps. It is based on a pre-filtering stage, allowing image denoising, compact source suppression and enhancement of diffuse emission, followed by an adaptive superpixel clustering stage for final source segmentation. A parametrization stage provides source flux information and a wide range of morphology estimators for post-processing analysis. We developed CAESAR in a modular software library, also including different methods for local background estimation and image filtering, along with alternative algorithms for both compact and diffuse source extraction. The method was applied to real radio continuum data collected at the Australian Telescope Compact Array (ATCA) within the SCORPIO project, a pathfinder of the Evolutionary Map of the Universe (EMU) survey at the Australian Square Kilometre Array Pathfinder (ASKAP). The source reconstruction capabilities were studied over different test fields in the presence of compact sources, imaging artefacts and diffuse emission from the Galactic plane and compared with existing algorithms. When compared to a human-driven analysis, the designed algorithm was found capable of detecting known target sources and regions of diffuse emission, outperforming alternative approaches over the considered fields.

Microsatellite markers used for genome-wide association mapping of partial resistance to Sclerotinia sclerotiorum in a world collection of Brassica napus.

PubMed

Gyawali, Sanjaya; Harrington, Myrtle; Durkin, Jonathan; Horner, Kyla; Parkin, Isobel A P; Hegedus, Dwayne D; Bekkaoui, Diana; Buchwaldt, Lone

The fungal pathogen Sclerotinia sclerotiorum causes stem rot of oilseed rape ( Brassica napus ) worldwide. In preparation for genome-wide association mapping (GWAM) of sclerotinia resistance in B. napus , 152 accessions from diverse geographical regions were screened with a single Canadian isolate, #321. Plants were inoculated by attaching mycelium plugs to the main stem at full flower. Lesion lengths measured 7, 14 and 21 days after inoculation were used to calculate the area under the disease progress curve (AUDPC). Depth of penetration was noted and used to calculate percent soft and collapsed lesions (% s + c). The two disease traits were highly correlated ( r  = 0.93). Partially resistant accessions (AUDPC <7 and % s + c <2) were identified primarily from South Korea and Japan with a few from Pakistan, China and Europe. Genotyping of accessions with 84 simple sequence repeat markers provided 690 polymorphic loci for GWAM. The general linear model in TASSEL best fitted the data when adjusted for population structure (STRUCTURE), GLM + Q. After correction for positive false discovery rate, 34 loci were significantly associated with both disease traits of which 21 alleles contributed to resistance, while the remaining enhanced susceptibility. The phenotypic variation explained by the loci ranged from 6 to 25 %. Five loci mapped to published quantitative trait loci conferring sclerotinia resistance in Chinese lines.

Microtubules (tau) as an emerging therapeutic target: NAP (davunetide).

PubMed

Gozes, Illana

2011-01-01

This review focuses on the discovery of activity-dependent neuroprotective protein (ADNP) and the ensuing discovery of NAP (davunetide) toward clinical development with emphasis on microtubule protection. ADNP immunoreactivity was shown to occasionally decorate microtubules and ADNP silencing inhibited neurite outgrowth as measured by microtubule associated protein 2 (MAP2) labeling. ADNP knockout is lethal, while 50% reduction in ADNP (ADNP haploinsufficiency) resulted in the microtubule associated protein tau pathology coupled to cognitive dysfunction and neurodegeneration. NAP (davunetide), an eight amino acid peptide derived from ADNP partly ameliorated deficits associated with ADNP deficiency. NAP (davunetide) interacted with microtubules, protected against microtubule toxicity associated with zinc, nocodazole and oxidative stress in vitro and against tau pathology and MAP6 (stable tubuleonly polypeptide - STOP) pathology in vivo. NAP (davunetide) provided neurotrophic functions promoting neurite outgrowth as measured by increases in MAP2 immunoreactivity and synapse formation by increasing synaptophysin expression. NAP (davunetide) protection against neurodegeneration has recently been shown to extend to katanin-related microtubule disruption under conditions of tau deficiencies. In conclusion, NAP (davunetide) provided potent neuroprotection in a broad range of neurodegenerative models, protecting the neuroglial cytoskeleton in vitro and inhibiting tau pathology (tauopathy) in vivo. Based on these extensive preclinical results, davunetide (NAP) is now being evaluated in a Phase II/III study of the tauopathy, progressive supranuclear palsy (PSP); (Allon Therapeutics Inc.).

The pig genome project has plenty to squeal about.

PubMed

Fan, B; Gorbach, D M; Rothschild, M F

2011-01-01

Significant progress on pig genetics and genomics research has been witnessed in recent years due to the integration of advanced molecular biology techniques, bioinformatics and computational biology, and the collaborative efforts of researchers in the swine genomics community. Progress on expanding the linkage map has slowed down, but the efforts have created a higher-resolution physical map integrating the clone map and BAC end sequence. The number of QTL mapped is still growing and most of the updated QTL mapping results are available through PigQTLdb. Additionally, expression studies using high-throughput microarrays and other gene expression techniques have made significant advancements. The number of identified non-coding RNAs is rapidly increasing and their exact regulatory functions are being explored. A publishable draft (build 10) of the swine genome sequence was available for the pig genomics community by the end of December 2010. Build 9 of the porcine genome is currently available with Ensembl annotation; manual annotation is ongoing. These drafts provide useful tools for such endeavors as comparative genomics and SNP scans for fine QTL mapping. A recent community-wide effort to create a 60K porcine SNP chip has greatly facilitated whole-genome association analyses, haplotype block construction and linkage disequilibrium mapping, which can contribute to whole-genome selection. The future 'systems biology' that integrates and optimizes the information from all research levels can enhance the pig community's understanding of the full complexity of the porcine genome. These recent technological advances and where they may lead are reviewed. Copyright © 2011 S. Karger AG, Basel.

Blood pressure, brain structure, and cognition: opposite associations in men and women.

PubMed

Cherbuin, Nicolas; Mortby, Moyra E; Janke, Andrew L; Sachdev, Perminder S; Abhayaratna, Walter P; Anstey, Kaarin J

2015-02-01

Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time course or patterns in cardiovascular disease progression. The aim of this study was to investigate the impact of sex on associations between blood pressure, regional cerebral volumes, and cognitive function in older individuals. In this cohort study, brachial blood pressure was measured twice at rest in 266 community-based individuals free of dementia aged 68-73 years who had also undergone a brain scan and a neuropsychological assessment. Associations between mean blood pressure (MAP), regional brain volumes, and cognition were investigated with voxel-wise regression analyses. Positive associations between MAP and regional volumes were detected in men, whereas negative associations were found in women. Similarly, there were sex differences in the brain-volume cognition relationship, with a positive relationship between regional brain volumes associated with MAP in men and a negative relationship in women. In this cohort of older individuals, higher MAP was associated with larger regional volume and better cognition in men, whereas opposite findings were demonstrated in women. These effects may be due to different lifetime risk exposure or because of physiological differences between men and women. Future studies investigating the relationship between blood pressure and brain structure or cognitive function should evaluate the potential for differential sex effects. © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Deciphering the Epigenetic Code: An Overview of DNA Methylation Analysis Methods

PubMed Central

Umer, Muhammad

2013-01-01

Abstract Significance: Methylation of cytosine in DNA is linked with gene regulation, and this has profound implications in development, normal biology, and disease conditions in many eukaryotic organisms. A wide range of methods and approaches exist for its identification, quantification, and mapping within the genome. While the earliest approaches were nonspecific and were at best useful for quantification of total methylated cytosines in the chunk of DNA, this field has seen considerable progress and development over the past decades. Recent Advances: Methods for DNA methylation analysis differ in their coverage and sensitivity, and the method of choice depends on the intended application and desired level of information. Potential results include global methyl cytosine content, degree of methylation at specific loci, or genome-wide methylation maps. Introduction of more advanced approaches to DNA methylation analysis, such as microarray platforms and massively parallel sequencing, has brought us closer to unveiling the whole methylome. Critical Issues: Sensitive quantification of DNA methylation from degraded and minute quantities of DNA and high-throughput DNA methylation mapping of single cells still remain a challenge. Future Directions: Developments in DNA sequencing technologies as well as the methods for identification and mapping of 5-hydroxymethylcytosine are expected to augment our current understanding of epigenomics. Here we present an overview of methodologies available for DNA methylation analysis with special focus on recent developments in genome-wide and high-throughput methods. While the application focus relates to cancer research, the methods are equally relevant to broader issues of epigenetics and redox science in this special forum. Antioxid. Redox Signal. 18, 1972–1986. PMID:23121567

Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae.

PubMed

Desfossés-Baron, Kristelle; Hammond-Martel, Ian; Simoneau, Antoine; Sellam, Adnane; Roberts, Stephen; Wurtele, Hugo

2016-10-26

The mechanism of action of valproate (VPA), a widely prescribed short chain fatty acid with anticonvulsant and anticancer properties, remains poorly understood. Here, the yeast Saccharomyces cerevisiae was used as model to investigate the biological consequences of VPA exposure. We found that low pH strongly potentiates VPA-induced growth inhibition. Transcriptional profiling revealed that under these conditions, VPA modulates the expression of genes involved in diverse cellular processes including protein folding, cell wall organisation, sexual reproduction, and cell cycle progression. We further investigated the impact of VPA on selected processes and found that this drug: i) activates markers of the unfolded protein stress response such as Hac1 mRNA splicing; ii) modulates the cell wall integrity pathway by inhibiting the activation of the Slt2 MAP kinase, and synergizes with cell wall stressors such as micafungin and calcofluor white in preventing yeast growth; iii) prevents activation of the Kss1 and Fus3 MAP kinases of the mating pheromone pathway, which in turn abolishes cellular responses to alpha factor; and iv) blocks cell cycle progression and DNA replication. Overall, our data identify heretofore unknown biological responses to VPA in budding yeast, and highlight the broad spectrum of cellular pathways influenced by this chemical in eukaryotes.

Towards a Global Land Subsidence Map

NASA Astrophysics Data System (ADS)

Erkens, G.; Kooi, H.; Sutanudjaja, E.

2017-12-01

Land subsidence is a global problem, but a global land subsidence map is not available yet. Such map is crucial to raise global awareness of land subsidence, as land subsidence causes extensive damage (probably in the order of billions of dollars annually). Insights in the rates of subsidence are particularly relevant for low lying deltas and coastal zones, for which any further loss in elevation is unwanted. With the global land subsidence map relative sea level rise predictions may be improved, contributing to global flood risk calculations. In this contribution, we discuss the approach and progress we have made so far in making a global land subsidence map. The first results will be presented and discussed, and we give an outlook on the work needed to derive a global land subsidence map.

GeoMapApp Learning Activities: Grab-and-go inquiry-based geoscience activities that bring cutting-edge technology to the classroom

NASA Astrophysics Data System (ADS)

Goodwillie, A. M.; Kluge, S.

2011-12-01

NSF-funded GeoMapApp Learning Activities (http://serc.carleton.edu/geomapapp) provide self-contained learning opportunities that are centred around the principles of guided inquiry. The activities allow students to interact with and analyse research-quality geoscience data to explore and enhance student understanding of underlying geoscience content and concepts. Each activity offers ready-to-use step-by-step student instructions and answer sheets that can be downloaded from the web page. Also provided are annotated teacher versions of the worksheets that include teaching tips, additional content and suggestions for further work. Downloadable pre- and post- quizzes tied to each activity help educators gauge the learning progression of their students. Short multimedia tutorials and details on content alignment with state and national teaching standards round out the package of material that comprises each "grab-and-go" activity. GeoMapApp Learning Activities expose students to content and concepts typically found at the community college, high school and introductory undergraduate levels. The activities are based upon GeoMapApp (http://www.geomapapp.org), a free, easy-to-use map-based data exploration and visualisation tool that allows students to access a wide range of geoscience data sets in a virtual lab-like environment. Activities that have so far been created under this project include student exploration of seafloor spreading rates, a study of mass wasting as revealed through geomorphological evidence, and an analysis of plate motion and hotspot traces. The step-by-step instructions and guided inquiry approach lead students through each activity, thus reducing the need for teacher intervention whilst also boosting the time that students can spend on productive exploration and learning. The activities can be used, for example, in a classroom lab with the educator present and as self-paced assignments in an out-of-class setting. GeoMapApp Learning Activities are hosted on the SERC-Carleton web site.

Global soil-climate-biome diagram: linking soil properties to climate and biota

NASA Astrophysics Data System (ADS)

Zhao, X.; Yang, Y.; Fang, J.

2017-12-01

As a critical component of the Earth system, soils interact strongly with both climate and biota and provide fundamental ecosystem services that maintain food, climate, and human security. Despite significant progress in digital soil mapping techniques and the rapidly growing quantity of observed soil information, quantitative linkages between soil properties, climate and biota at the global scale remain unclear. By compiling a large global soil database, we mapped seven major soil properties (bulk density [BD]; sand, silt and clay fractions; soil pH; soil organic carbon [SOC] density [SOCD]; and soil total nitrogen [STN] density [STND]) based on machine learning algorithms (regional random forest [RF] model) and quantitatively assessed the linkage between soil properties, climate and biota at the global scale. Our results demonstrated a global soil-climate-biome diagram, which improves our understanding of the strong correspondence between soils, climate and biomes. Soil pH decreased with greater mean annual precipitation (MAP) and lower mean annual temperature (MAT), and the critical MAP for the transition from alkaline to acidic soil pH decreased with decreasing MAT. Specifically, the critical MAP ranged from 400-500 mm when the MAT exceeded 10 °C but could decrease to 50-100 mm when the MAT was approximately 0 °C. SOCD and STND were tightly linked; both increased in accordance with lower MAT and higher MAP across terrestrial biomes. Global stocks of SOC and STN were estimated to be 788 ± 39.4 Pg (1015 g, or billion tons) and 63 ± 3.3 Pg in the upper 30-cm soil layer, respectively, but these values increased to 1654 ± 94.5 Pg and 133 ± 7.8 Pg in the upper 100-cm soil layer, respectively. These results reveal quantitative linkages between soil properties, climate and biota at the global scale, suggesting co-evolution of the soil, climate and biota under conditions of global environmental change.

Molecular subtyping of bladder cancer using Kohonen self-organizing maps

PubMed Central

Borkowska, Edyta M; Kruk, Andrzej; Jedrzejczyk, Adam; Rozniecki, Marek; Jablonowski, Zbigniew; Traczyk, Magdalena; Constantinou, Maria; Banaszkiewicz, Monika; Pietrusinski, Michal; Sosnowski, Marek; Hamdy, Freddie C; Peter, Stefan; Catto, James WF; Kaluzewski, Bogdan

2014-01-01

Kohonen self-organizing maps (SOMs) are unsupervised Artificial Neural Networks (ANNs) that are good for low-density data visualization. They easily deal with complex and nonlinear relationships between variables. We evaluated molecular events that characterize high- and low-grade BC pathways in the tumors from 104 patients. We compared the ability of statistical clustering with a SOM to stratify tumors according to the risk of progression to more advanced disease. In univariable analysis, tumor stage (log rank P = 0.006) and grade (P < 0.001), HPV DNA (P < 0.004), Chromosome 9 loss (P = 0.04) and the A148T polymorphism (rs 3731249) in CDKN2A (P = 0.02) were associated with progression. Multivariable analysis of these parameters identified that tumor grade (Cox regression, P = 0.001, OR.2.9 (95% CI 1.6–5.2)) and the presence of HPV DNA (P = 0.017, OR 3.8 (95% CI 1.3–11.4)) were the only independent predictors of progression. Unsupervised hierarchical clustering grouped the tumors into discreet branches but did not stratify according to progression free survival (log rank P = 0.39). These genetic variables were presented to SOM input neurons. SOMs are suitable for complex data integration, allow easy visualization of outcomes, and may stratify BC progression more robustly than hierarchical clustering. PMID:25142434

78 FR 1918 - Public-Private Partnerships Public Meeting and Request for Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... complexities in P3 agreements, tasked the USDOT, via the Moving Ahead for Progress in the 21st Century Act (MAP...), DOT. ACTION: Public meeting notice; request for comment. SUMMARY: The USDOT/FHWA is tasked by MAP-21... be conducted on Wednesday, January 16, 2013, from 12:00 p.m. to 4:00 p.m., e.t. ADDRESSES: Comment...

Use of MAGSAT anomaly data for crustal structure and mineral resources in the US midcontinent

NASA Technical Reports Server (NTRS)

Carmichael, R. S. (Principal Investigator)

1982-01-01

Progress in the correlation of MAGSAT anomaly maps with geological and geophysical data sets is reported. An excerpt from Bouguer gravity map of the U.S. was filtered to retain wavelengths of 250 km, thus being physically somewhat analogous to MAGSAT data at 400 km height. Residual anomalies were extracted to compare with the satellite magnetics.

Progress and pitfalls in finding the 'missing proteins' from the human proteome map.

PubMed

Segura, Victor; Garin-Muga, Alba; Guruceaga, Elizabeth; Corrales, Fernando J

2017-01-01

The Human Proteome Project was launched with two main goals: the comprehensive and systematic definition of the human proteome map and the development of ready to use analytical tools to measure relevant proteins in their biological context in health and disease. Despite the great progress in this endeavour, there is still a group of reluctant proteins with no, or scarce, experimental evidence supporting their existence. These are called the 'missing proteins' and represent one of the biggest challenges to complete the human proteome map. Areas covered: This review focuses on the description of the missing proteome based on the HUPO standards, the analysis of the reasons explaining the difficulty of detecting missing proteins and the strategies currently used in the search for missing proteins. The present and future of the quest for the missing proteins is critically revised hereafter. Expert commentary: An overarching multidisciplinary effort is currently being done under the HUPO umbrella to allow completion of the human proteome map. It is expected that the detection of missing proteins will grow in the coming years since the methods and the best tissue/cell type sample for their search are already on the table.

Assessing MODIS-based Products and Techniques for Detecting Gypsy Moth Defoliation

NASA Technical Reports Server (NTRS)

Spruce, Joseph P.; Hargrove, William; Smoot, James C.; Prados, Don; McKellip, Rodney; Sader, Steven A.; Gasser, Jerry; May, George

2008-01-01

The project showed potential of MODIS and VIIRS time series data for contributing defoliation detection products to the USFS forest threat early warning system. This study yielded the first satellite-based wall-to-wall 2001 gypsy moth defoliation map for the study area. Initial results led to follow-on work to map 2007 gypsy moth defoliation over the eastern United States (in progress). MODIS-based defoliation maps offer promise for aiding aerial sketch maps either in planning surveys and/or adjusting acreage estimates of annual defoliation. More work still needs to be done to assess potential of technology for "now casts"of defoliation.

TRENDS IN ENGINEERING GEOLOGIC AND RELATED MAPPING.

USGS Publications Warehouse

Varnes, David J.; Keaton, Jeffrey R.

1983-01-01

Progress is reviewed that has been made during the period 1972-1982 in producing medium- and small-scale engineering geologic maps with a variety of content. Improved methods to obtain and present information are evolving. Standards concerning text and map content, soil and rock classification, and map symbols have been proposed. Application of geomorphological techniques in terrain evaluation has increased, as has the use of aerial photography and other remote sensing. Computers are being used to store, analyze, retrieve, and print both text and map information. Development of offshore resources, especially petroleum, has led to marked improvement and growth in marine engineering geology and geotechnology. Coordinated planning for societal needs has required broader scope and increased complexity of both engineering geologic and environmental geologic studies. Refs.

Bedrock geology of the Mount Carmel and Southington quadrangles, Connecticut

USGS Publications Warehouse

Fritts, Crawford Ellswroth

1962-01-01

New data concerning the geologic structure, stratigraphy, petrography, origin, and ages of bedrock formations in an area of approximately 111 square miles in south-central Connecticut were obtained in the course of detailed geologic mapping from 1957 to 1960. Mapping was done at a scale of 1:24,000 on topographic base maps having a 10-foot contour interval. Bedrock formations are classified in two principal categories. The first includes metasedimentary, meta-igneous, and igneous rocks of Precambrian to Devonian age, which crop out in the western parts of both quadrangles. The second includes sedimentary and igneous rocks of the Newark Group of Late Triassic age, which crop out in the eastern parts of the quadrangles. Diabase dikes, which are Late Triassic or younger in age, intruded rocks in both the western and eastern parts of the map area. Rocks in the western part of the area underwent progressive regional metamorphism in Middle to Late Devonian time. The arrangement of the chlorite, garnet, biotite, staurolite, and kyanite zones here is approximately the mirror-image of metamorphic zones in Dutchess County, New York. However, garnet appeared before biotite in politic rocks in the map area, because the ration MgO/FeO is low. Waterbury Gneiss and the intrusive Woodtick Gneiss are parts of a basement complex of Precambrian age, which forms the core of the Waterbury dome. This structure is near the southern end of a line of similar domes that lie along the crest of a geanticline east of the Green Mountain anticlinorium. The Waterbury Gneiss is believed to have been metamorphosed in Precambrian time as well as in Paleozoic time. The Woodtick Gneiss also may have been metamorphosed more than once. In Paleozoic time, sediments were deposited in geosynclines during two main cycles of sedimentation. The Straits, Southington Mountain, and Derby Hill Schists, which range in age from Cambrian to Ordovician, reflect a transition from relatively clean politic sediments to thinly layered sediments that contained rather high percentages of fine-grained volcanic debris. Metadiabase and metabasalt extrusives above Derby Hill Schist south of the map area represent more intense volcanic activity before or during the early stages of the Taconic disturbance in Late Ordovician time. Impure argillaceous, siliceous, and minor calcareous sediments of the Wepawaug Schist, which is Silurian and Devonian in age, were deposited unconformably on older rocks during renewed subsidence of a geosyncline. The Wepawaug now occupies the trough of a tight syncline, which formed before and during progressive regional metamorphism at the time of the Acadian orogeny in middle to Late Devonian time. Felsic igneous rocks were intruded into the metasedimentary formations of Paleozoic age before the climax of the latest progressive regional metamorphism. Intrusives that gave rise to the Prospect and Ansonia Gneisses were emplaced mainly in the Southington Mountain Schist, and the igneous rocks as well as the host rocks were metamorphosed in the staurolite zone. Although it is possible that these two intrusives were emplaced during the Taconic disturbance, the writer believes it more likely that the igneous rocks from which the Prospect and Ansonia Gneisses formed were emplaced during the Acadian orogeny. Woodbridge Granite, which intruded the Wepawaug Schist, is Devonian in age and undoubtedly was emplaced during the Acadian orogeny. In this area the granite is essentially unmetamorphosed, because it is in the chlorite, garnet, and biotite zones. Southwest of the map area, however, metamorphic equivalents of the Woodbridge are found in Wepawaug Schist in the staurolite zone. The Ansonia Gneiss, therefore, may be a metamorphic equivalent of the Woodbridge Granite. Rocks of Late Triassic age formerly covered the entire map area, but were eroded from the western part after tilting and faulting in Late Triassic time. The New Haven Arkose of the Newark

Rossby-gravity waves in tropical total ozone data

NASA Technical Reports Server (NTRS)

Stanford, J. L.; Ziemke, J. R.

1993-01-01

Evidence for Rossby-gravity waves in tropical data fields produced by the European Center for Medium Range Weather Forecasts (ECMWF) was recently reported. Similar features are observable in fields of total column ozone from the Total Ozone Mapping Spectrometer (TOMS) satellite instrument. The observed features are episodic, have zonal (east-west) wavelengths of 6,000-10,000 km, and oscillate with periods of 5-10 days. In accord with simple linear theory, the modes exhibit westward phase progression and eastward group velocity. The significance of finding Rossby-gravity waves in total ozone fields is that (1) the report of similar features in ECMWF tropical fields is corroborated with an independent data set and (2) the TOMS data set is demonstrated to possess surprising versatility and sensitivity to relatively smaller scale tropical phenomena.

Hierarchical tone mapping for high dynamic range image visualization

NASA Astrophysics Data System (ADS)

Qiu, Guoping; Duan, Jiang

2005-07-01

In this paper, we present a computationally efficient, practically easy to use tone mapping techniques for the visualization of high dynamic range (HDR) images in low dynamic range (LDR) reproduction devices. The new method, termed hierarchical nonlinear linear (HNL) tone-mapping operator maps the pixels in two hierarchical steps. The first step allocates appropriate numbers of LDR display levels to different HDR intensity intervals according to the pixel densities of the intervals. The second step linearly maps the HDR intensity intervals to theirs allocated LDR display levels. In the developed HNL scheme, the assignment of LDR display levels to HDR intensity intervals is controlled by a very simple and flexible formula with a single adjustable parameter. We also show that our new operators can be used for the effective enhancement of ordinary images.

Geologic map of the Boulder-Fort Collins-Greeley Area, Colorado

USGS Publications Warehouse

Colton, Roger B.

1978-01-01

This digital map shows the geographic extent of rock stratigraphic units (formations) as compiled by Colton in 1976 under the Front Range Urban Corridor Geology Program. Colton used his own geologic mapping and previously published geologic maps to compile one map having a single classification of geologic units. The resulting published color paper map (USGS Map I-855-G, Colton, 1978) was intended for land-use planning and to depict the regional geology. In 1997-1999, another USGS project designed to address urban growth issues was undertaken. This project, the USGS Front Range Infrastructure Resources Project, undertook to digitize Colton's map at 1:100,000 scale, making it useable in Geographical Information Systems (GIS). That product is described here. In general, the digitized map depicts in its western part Precambrian igneous and metamorphic rocks, Pennsylvanian and younger sedimentary rock units, major faults, and brecciated zones along an eastern strip (5-20 km wide) of the Front Range. The central and eastern parts of the map (Colorado Piedmont) show a mantle of Quaternary unconsolidated deposits and interspersed outcrops of sedimentary rock of Cretaceous or Tertiary age. A surficial mantle of unconsolidated deposits of Quaternary age is differentiated and depicted as eolium (wind-blown sand and silt), alluvium (river gravel, sand, and silt of variable composition), colluvium, and a few landslide deposits. At the mountain front, north-trending, Paleozoic and Mesozoic formations of sandstone, shale, and minor limestone dip mostly eastward and form folds, fault blocks, hogbacks and intervening valleys. Local dikes and sills of Tertiary rhyodacite and basalt intrude rocks near the range front, mostly in the Boulder area.

ACTIM: an EDA initiated study on spectral active imaging

NASA Astrophysics Data System (ADS)

Steinvall, O.; Renhorn, I.; Ahlberg, J.; Larsson, H.; Letalick, D.; Repasi, E.; Lutzmann, P.; Anstett, G.; Hamoir, D.; Hespel, L.; Boucher, Y.

2010-10-01

This paper will describe ongoing work from an EDA initiated study on Active Imaging with emphasis of using multi or broadband spectral lasers and receivers. Present laser based imaging and mapping systems are mostly based on a fixed frequency lasers. On the other hand great progress has recently occurred in passive multi- and hyperspectral imaging with applications ranging from environmental monitoring and geology to mapping, military surveillance, and reconnaissance. Data bases on spectral signatures allow the possibility to discriminate between different materials in the scene. Present multi- and hyperspectral sensors mainly operate in the visible and short wavelength region (0.4-2.5 μm) and rely on the solar radiation giving shortcoming due to shadows, clouds, illumination angles and lack of night operation. Active spectral imaging however will largely overcome these difficulties by a complete control of the illumination. Active illumination enables spectral night and low-light operation beside a robust way of obtaining polarization and high resolution 2D/3D information. Recent development of broadband lasers and advanced imaging 3D focal plane arrays has led to new opportunities for advanced spectral and polarization imaging with high range resolution. Fusing the knowledge of ladar and passive spectral imaging will result in new capabilities in the field of EO-sensing to be shown in the study. We will present an overview of technology, systems and applications for active spectral imaging and propose future activities in connection with some prioritized applications.

The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kapfhamer, D.; Sufalko, D.; Warren, S.

1996-08-01

Jittery (ji) is a recessive mouse mutation on Chromosome 10 characterized by progressive ataxic gait, dystonic movements, spontaneus seizures, and death by dehydration/starvation before fertility. Recently, a viable neurological recessive mutation, hesitant, was discovered. It is characterized by hesitant, uncoordinated movements, exaggerated stepping of the hind limbs, and reduced fertility in males. In a complementation test and by genetic mapping we have shown here that hesitant and jittery are allelic. Using several large intersubspecific backcrosses and intercrosses we have genetically mapped ji near the marker Amh and microsatellite markers D10Mit7, D10Mit21, and D10Mit23. The linked region of mouse Chromosome 10more » is homologous to human 19p13.3, to which several human ataxia loci have recently been mapped. By excluding genes that map to human 21q22.3 (Pfkl) and 12q23 (Nfyb), we conclude that jittery is not likely to be a genetic mouse model for human Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) on 21q22.3 nor for spinocerebellar ataxia II (SCA2) on 12q22-q24. The closely linked markers presented here will facilitate positional cloning of the ji gene. 31 refs., 2 figs.« less

Gravity and magnetic anomaly data analysis

NASA Technical Reports Server (NTRS)

Braile, L. W.; Hinze, W. J.; Vonfrese, R. R. B. (Principal Investigator)

1982-01-01

Progress on the analysis MAGSAT data is reported. The MAGSAT data from 40 deg S to 70 deg N latitude and 30 deg W to 60 E longitude was reduced to radial polarization. In addition, gravity anomaly data from this area were processed and a variety of filtered maps were prepared for combined interpretation of the gravity and magnetic data in conjunction with structural and tectonic maps of the area. The VERSATEC listings and cross-reference maps of variable and array names for the spherical Earth analysis programs NVERTSM, SMFLD, NVERTG, and GFLD were also prepared.

Predictive Utility and Classification Accuracy of Oral Reading Fluency and the Measures of Academic Progress for the Wisconsin Knowledge and Concepts Exam

ERIC Educational Resources Information Center

Ball, Carrie R.; O'Connor, Edward

2016-01-01

This study examined the predictive validity and classification accuracy of two commonly used universal screening measures relative to a statewide achievement test. Results indicated that second-grade performance on oral reading fluency and the Measures of Academic Progress (MAP), together with special education status, explained 68% of the…

Recent achievements in restorative neurology: Progressive neuromuscular diseases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dimitrijevic, M.R.; Kakulas, B.A.; Vrbova, G.

1986-01-01

This book contains 27 chapters. Some of the chapter titles are: Computed Tomography of Muscles in Neuromuscular Disease; Mapping the Genes for Muscular Dystrophy; Trophic Factors and Motor Neuron Development; Size of Motor Units and Firing Rate in Muscular Dystrophy; Restorative Possibilities in Relation to the Pathology of Progressive Neuromuscular Disease; and An Approach to the Pathogenesis of some Congenital Myopathies.

AUV Reveals Deep-Water Coral Mound Distribution, Morphology and Oceanography in the Florida Straits

NASA Astrophysics Data System (ADS)

Grasmueck, M.; Eberli, G. P.; Viggiano, D. A.; Correa, T.; Rathwell, G.; Luo, J.

2006-12-01

Since the 1960's dredge sampling and submersible dives have discovered numerous mound-forming deep- water corals in water depths of 400-800 m in the Straits of Florida. This extensive collection of samples and observations however can not be put into a geomorphologic context as existing bathymetric charts do not resolve coral mounds. To make progress in understanding the distribution and genesis of coral mounds, maps of morphology and oceanographic conditions resolving features at the 1-10 m scale are needed. On 11-18 December 2005 the C-Surveyor II(TM) mapped five sites ranging from 14-48 km2 in 590-875 m water acquiring 1-3 m resolution bathymetry and acoustic backscatter together with subbottom profiles, current vectors, salinity, and temperature. The areas mapped with the AUV contain hundreds of coral mounds with heights of 1-120 m. Mound distribution, morphology and currents are different for each survey site. Coral mounds develop on off-bank transported sediment ridges and slump features at the toe-of-slope of Great Bahama bank, while chevron pattern ridges and sinusoidal ridges are found further east in the Straits. Currents range from 0.1-0.5 m/s. At two sites currents reversed every 6 hours indicating tidal control. The AUV surveys and subsequent ground truthing with a drop camera and a submersible revealed a surprising abundance and diversity of deep-water coral habitats. The boundaries between mound fields and the barren muddy or sandy seafloor are sharp. Hull- mounted multi-beam reconnaissance mapping helped us select the most promising coral mound areas to optimize the use of valuable AUV time. Such combined use of hull-mounted and AUV-based mapping enables efficient environmental characterization of large deep-water regions such as the Florida Straits. The synoptic high-resolution datasets acquired by the multiple sensors on board the AUV enable for the first time a comprehensive assessment of deep-water coral mound ecosystems. Utilization of such state-of-the-art deepwater exploration tools is essential to understand and protect these slow growing and fragile oases which are resources for seafood, new medicines and long-term climate records. The AUV data will guide future sampling and monitoring to critical locations and provide the geospatial framework for making inventories of mound resources and designing research and management plans.

Using concept mapping for assessing and promoting relational conceptual change in science

NASA Astrophysics Data System (ADS)

Liu, Xiufeng

2004-05-01

In this article, we adopted the relational conceptual change as our theoretical framework to accommodate current views of conceptual change such as ontological beliefs, epistemological commitment, and social/affective contexts commonly mentioned in the literature. We used a specific concept mapping format and process - digraphs and digraphing - as an operational framework for assessing and promoting relational conceptual change. We wanted to find out how concept mapping can be used to account for relational conceptual change. We collected data from a Grade 12 chemistry class using collaborative computerized concept mapping on an ongoing basis during a unit of instruction. Analysis of progressive concept maps and interview transcripts of representative students and the teacher showed that ongoing and collaborative computerized concept mapping is able to account for student conceptual change in ontological, epistemological, and social/affective domains.

X-MATE: a flexible system for mapping short read data

PubMed Central

Pearson, John V.; Cloonan, Nicole; Grimmond, Sean M.

2011-01-01

Summary: Accurate and complete mapping of short-read sequencing to a reference genome greatly enhances the discovery of biological results and improves statistical predictions. We recently presented RNA-MATE, a pipeline for the recursive mapping of RNA-Seq datasets. With the rapid increase in genome re-sequencing projects, progression of available mapping software and the evolution of file formats, we now present X-MATE, an updated version of RNA-MATE, capable of mapping both RNA-Seq and DNA datasets and with improved performance, output file formats, configuration files, and flexibility in core mapping software. Availability: Executables, source code, junction libraries, test data and results and the user manual are available from http://grimmond.imb.uq.edu.au/X-MATE/. Contact: n.cloonan@uq.edu.au; s.grimmond@uq.edu.au Supplementary information: Supplementary data are available at Bioinformatics Online. PMID:21216778

Toward Integration of Comparative Genetic, Physical, Diversity, and Cytomolecular Maps for Grasses and Grains, Using the Sorghum Genome as a Foundation1

PubMed Central

Draye, Xavier; Lin, Yann-Rong; Qian, Xiao-yin; Bowers, John E.; Burow, Gloria B.; Morrell, Peter L.; Peterson, Daniel G.; Presting, Gernot G.; Ren, Shu-xin; Wing, Rod A.; Paterson, Andrew H.

2001-01-01

The small genome of sorghum (Sorghum bicolor L. Moench.) provides an important template for study of closely related large-genome crops such as maize (Zea mays) and sugarcane (Saccharum spp.), and is a logical complement to distantly related rice (Oryza sativa) as a “grass genome model.” Using a high-density RFLP map as a framework, a robust physical map of sorghum is being assembled by integrating hybridization and fingerprint data with comparative data from related taxa such as rice and using new methods to resolve genomic duplications into locus-specific groups. By taking advantage of allelic variation revealed by heterologous probes, the positions of corresponding loci on the wheat (Triticum aestivum), rice, maize, sugarcane, and Arabidopsis genomes are being interpolated on the sorghum physical map. Bacterial artificial chromosomes for the small genome of rice are shown to close several gaps in the sorghum contigs; the emerging rice physical map and assembled sequence will further accelerate progress. An important motivation for developing genomic tools is to relate molecular level variation to phenotypic diversity. “Diversity maps,” which depict the levels and patterns of variation in different gene pools, shed light on relationships of allelic diversity with chromosome organization, and suggest possible locations of genomic regions that are under selection due to major gene effects (some of which may be revealed by quantitative trait locus mapping). Both physical maps and diversity maps suggest interesting features that may be integrally related to the chromosomal context of DNA—progress in cytology promises to provide a means to elucidate such relationships. We seek to provide a detailed picture of the structure, function, and evolution of the genome of sorghum and its relatives, together with molecular tools such as locus-specific sequence-tagged site DNA markers and bacterial artificial chromosome contigs that will have enduring value for many aspects of genome analysis. PMID:11244113

Map of debris flows caused by rainfall during 1996 in parts of the Reedsport and Deer Head Point quadrangles, Douglas County, southern Coast Range, Oregon

USGS Publications Warehouse

Coe, Jeffrey A.; Michael, John A.; Burgos, Marianela Mercado

2011-01-01

This 1:12,000-scale map shows an inventory of debris flows caused by rainfall during 1996 in a 94.4 km2 area in the southern Coast Range of Oregon. This map and associated digital data are part of a larger U.S. Geological Survey study of debris flows in the southern Coast Range. Available evidence indicates that the flows were triggered by a rain storm that occurred between November 17 and 19. The closest rain gage in the Coast Range (Goodwin Peak) recorded 245 mm during the storm. Maximum rainfall intensity during the storm was 13.2 mm/hr on November 18. Debris flows were photogrammetrically mapped from 1:12,000-scale aerial photographs flown in May, 1997. The inventory is presented on imagery derived from LiDAR data acquired in 2008. We classified mapped debris flows into four categories based on the type of debris-flow activity: (1) discrete slide source areas, (2) predominantly erosion, (3) predominantly transport or mixed erosion and deposition, and (4) predominantly deposition. Locations of woody-debris jams are also shown on the map. The area encompassed by debris flows is 2.1 percent of the 94.4 km2 map area.

Abstracts of the annual meeting of Planetary Geologic Mappers: June 21-22, 2002, Tempe, Arizona

USGS Publications Warehouse

Gregg, Tracy K. P.; Tanaka, Kenneth L.; Senske, David A.

2002-01-01

The annual meeting of planetary geologic mappers allows mappers the opportunity to exchange ideas, experiences, victories, and problems. In addition, presentations are reviewed by the Geologic Mapping Subcommittee (GEMS) to provide input to the Planetary Geology and Geophysics Mapping Program review panel’s consideration of new proposals and progress reports that include mapping tasks. Funded mappers bring both oral presentation materials (slides or viewgraphs) and map products to post for review by GEMS and fellow mappers. Additionally, the annual meetings typically feature optional field trips that offer Earth analogs and parallels to planetary mapping problems or workshops that provide information and status of current missions. The 2002 meeting of planetary geologic mappers was held June 21-22 at the Mars Flight Facility, Arizona State University, Tempe, Arizona. Dr. Phil Christensen graciously offered the use of the newly renovated facility, and Ms. Kelly Bender not only proved to be a courteous hostess, but also arranged a short workshop on June 23 regarding TES and THEMIS data. Approximately 30 people attended each day of the 2-day meeting, although not the same 30—some attended only on Thursday and others only on Friday. On Thursday, eight mappers gave oral presentations of Mars mapping, and an additional two presentations were presented as posters only. Eight oral presentations on Venus mapping were given on Friday, and an additional four presentations were posters only. Twelve people attended the TES/THEMIS workshop. Presentations of Ganymede mapping and Europa mapping (the latter not yet financially sponsored by PG&G mapping program) were also given on Friday. Aside from the regular presentations of maps-in-progress, there were some additional talks. Lisa Gaddis (USGS) presented a proposal seeking support for a new lunar mapping program in light of all the new data available; she made a good case that the GEMS panel discussed. Jim Skinner (USGS) gave a short presentation on free (or nearly so) software available for 3D viewing of planetary surfaces. Healthy discussions focused on the review time for some maps and the use of different styles of correlation charts observed on the presented maps. Next year’s meeting will be held June 19-20 at Brown University, Providence, RI.

Transient Rotor Activity During Prolonged 3-Dimensional Phase Mapping in Human Persistent Atrial Fibrillation.

PubMed

Pathik, Bhupesh; Kalman, Jonathan M; Walters, Tomos; Kuklik, Pawel; Zhao, Jichao; Madry, Andrew; Prabhu, Sandeep; Nalliah, Chrishan; Kistler, Peter; Lee, Geoffrey

2018-01-01

This study sought to validate a 3-dimensional (3D) phase mapping system and determine the distribution of dominant propagation patterns in persistent atrial fibrillation (AF). Currently available systems display phase as simplified 2-dimensional maps. We developed a novel 3D phase mapping system that uses the 3D location of basket catheter electrodes and the patient's 3D left atrial surface geometry to interpolate phase and create a 3D representation of phase progression. Six-min AF recordings from the left atrium were obtained in 14 patients using the Constellation basket catheter and analyzed offline. Exported signals underwent both phase and traditional activation analysis and were then visualized using a novel 3D mapping system. Analysis involved: 1) validation of phase analysis by comparing beat-to-beat AF cycle length calculated using phase inversion with that determined from activation timing in the same 20-s segment; 2) validation of 3D phase by comparing propagation patterns observed using 3D phase with 3D activation in the same 1-min segment; and 3) determining the distribution of dominant propagation patterns in 6-min recordings using 3D phase. There was strong agreement of beat-to-beat AF cycle length between activation analysis and phase inversion (R 2  = 0.91). There was no significant difference between 3D activation and 3D phase in mean percentage of propagation patterns classified as single wavefronts (p = 0.99), focal activations (p = 0.26), disorganized activity (p = 0.76), or multiple wavefronts (p = 0.70). During prolonged 3D phase, single wavefronts were the most common propagation pattern (50.2%). A total of 34 rotors were seen in 9 of 14 patients. All rotors were transient with mean duration of 1.0 ± 0.6 s. Rotors were only observed in areas of high electrode density where the interelectrode distance was significantly shorter than nonrotor sites (7.4 [interquartile range: 6.3 to 14.6] vs. 15.3 mm [interquartile range: 10.1 to 22.2]; p < 0.001). During prolonged 3D phase mapping, transient rotors were observed in 64% of patients and reformed at the same anatomic location in 44% of patients. The electrode density of the basket catheter may limit the detection of rotors. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Molecular mapping of chromosomes 17 and X. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barker, D.F.

1989-12-31

The basic aims of this project are the construction of high density genetic maps of chromosomes 17 and X and the utilization of these maps for the subsequent isolation of a set of physically overlapping DNA segment clones. The strategy depends on the utilization of chromosome specific libraries of small (1--15 kb) segments from each of the two chromosomes. Since the time of submission of our previous progress report, we have refined the genetic map of markers which we had previously isolated for chromosome 17. We have completed our genetic mapping in CEPH reference and NF1 families of 15 markersmore » in the pericentric region of chromosome 17. Physical mapping results with three probes, were shown be in very close genetic proximity to the NF1 gene, with respect to two translocation breakpoints which disrupt the activity of the gene. All three of the probes were found to lie between the centromere and the most proximal translocation breakpoint, providing important genetic markers proximal to the NF1 gene. Our primary focus has shifted to the X chromosome. We have isolated an additional 30 polymorphic markers, bringing the total number we have isolated to over 80. We have invested substantial effort in characterizing the polymorphisms at each of these loci and constructed plasmid subclones which reveal the polymorphisms for nearly all of the loci. These subclones are of practical value in that they produce simpler and stronger patterns on human genomic Southern blots, thus improving the efficiency of the genetic mapping experiments. These subclones may also be of value for deriving DNA sequence information at each locus, necessary for establishing polymerase chain reaction primers specific for each locus. Such information would allow the use of each locus as a sequence tagged site.« less

Isotopic ages of rocks in the northern Front Range, Colorado

USGS Publications Warehouse

Wilson, Anna B.; Bryant, Bruce

2006-01-01

These maps, and the tables that accompany them, are a compilation of isotopic age determinations of rocks and minerals in four 1:100,000 quadrangles in the northern and central Front Range, Colorado. Phanerozoic (primarily Tertiary and Cretaceous) age data are shown on one map; Proterozoic data are on the other. A sample location map is included for ease of matching specific localities and data in the tables to the maps. Several records in the tables were not included in the maps because either there were ambiguous dates or lack of location precluded accurate plotting.

Integrating Landsat-derived disturbance maps with FIA inventory data: Applications for state-Level forest resource assessments

Treesearch

Sonja Oswalt; Chengquan Huang; Hua Shi; James Vogelmann; Zhiliang Zhu; Samuel N. Goward; John Coulston

2009-01-01

Landsat images have been widely used for assessing forest characteristics and dynamics. Recently, significant progress has been made towards indepth exploration of the rich Landsat archive kept by the U.S. Geological Survey to improve our under standing of forest disturbance and recovery processes. In this study, we used Landsat images to map forest disturbances at...

Some Challenges in the Empirical Investigation of Conceptual Mappings and Embodied Cognition in Science Education: Commentary on Dreyfus, Gupta and Redish; and Close and Scherr

ERIC Educational Resources Information Center

Núñez, Rafael

2015-01-01

The last couple of decades have seen an enormous development in the study of embodied cognition through the investigation of conceptual mappings, such as conceptual metaphor and conceptual blending. Initially, this progress was achieved at a theoretical level, and more recently through empirical research in basic science--from psycholinguistics,…

Power Lines: The Rhetoric of Maps as Social Change in the Post-Cold War Landscape

ERIC Educational Resources Information Center

Barney, Timothy

2009-01-01

After the fall of the Berlin Wall and the collapse of state socialism in Eastern and Central Europe, cartographers were faced with choices on how the new post-Cold War political landscape would be mapped. One such group called the Pluto Project had been producing atlases since 1981 with a progressive point of view about the nature of state power…

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

DOE PAGES

Spurrell, Cailyn H.; Dickel, Diane E.; Visel, Axel

2016-11-17

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. Here in this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.

Spatiotemporal Modeling for Fine-Scale Maps of Regional Malaria Endemicity and Its Implications for Transitional Complexities in a Routine Surveillance Network in Western Cambodia

PubMed Central

Okami, Suguru; Kohtake, Naohiko

2017-01-01

Due to the associated and substantial efforts of many stakeholders involved in malaria containment, the disease burden of malaria has dramatically decreased in many malaria-endemic countries in recent years. Some decades after the past efforts of the global malaria eradication program, malaria elimination has again featured on the global health agenda. While risk distribution modeling and a mapping approach are effective tools to assist with the efficient allocation of limited health-care resources, these methods need some adjustment and reexamination in accordance with changes occurring in relation to malaria elimination. Limited available data, fine-scale data inaccessibility (for example, household or individual case data), and the lack of reliable data due to inefficiencies within the routine surveillance system, make it difficult to create reliable risk maps for decision-makers or health-care practitioners in the field. Furthermore, the risk of malaria may dynamically change due to various factors such as the progress of containment interventions and environmental changes. To address the complex and dynamic nature of situations in low-to-moderate malaria transmission settings, we built a spatiotemporal model of a standardized morbidity ratio (SMR) of malaria incidence, calculated through annual parasite incidence, using routinely reported surveillance data in combination with environmental indices such as remote sensing data, and the non-environmental regional containment status, to create fine-scale risk maps. A hierarchical Bayesian frame was employed to fit the transitioning malaria risk data onto the map. The model was set to estimate the SMRs of every study location at specific time intervals within its uncertainty range. Using the spatial interpolation of estimated SMRs at village level, we created fine-scale maps of two provinces in western Cambodia at specific time intervals. The maps presented different patterns of malaria risk distribution at specific time intervals. Moreover, the visualized weights estimated using the risk model, and the structure of the routine surveillance network, represent the transitional complexities emerging from ever-changing regional endemic situations. PMID:29034229

New perspectives on archaeological prospecting: Multispectral imagery analysis from Army City, Kansas, USA

NASA Astrophysics Data System (ADS)

Banks, Benjamin Daniel

Aerial imagery analysis has a long history in European archaeology and despite early attempts little progress has been made to promote its use in North America. Recent advances in multispectral satellite and aerial sensors are helping to make aerial imagery analysis more effective in North America, and more cost effective. A site in northeastern Kansas is explored using multispectral aerial and satellite imagery allowing buried features to be mapped. Many of the problems associated with early aerial imagery analysis are explored, such as knowledge of archeological processes that contribute to crop mark formation. Use of multispectral imagery provides a means of detecting and enhancing crop marks not easily distinguishable in visible spectrum imagery. Unsupervised computer classifications of potential archaeological features permits their identification and interpretation while supervised classifications, incorporating limited amounts of geophysical data, provide a more detailed understanding of the site. Supervised classifications allow archaeological processes contributing to crop mark formation to be explored. Aerial imagery analysis is argued to be useful to a wide range of archeological problems, reducing person hours and expenses needed for site delineation and mapping. This technology may be especially useful for cultural resources management.

Development of the Brican TD100 Small Uas and Payload Trials

NASA Astrophysics Data System (ADS)

Eggleston, B.; McLuckie, B.; Koski, W. R.; Bird, D.; Patterson, C.; Bohdanov, D.; Liu, H.; Mathews, T.; Gamage, G.

2015-08-01

The Brican TD100 is a high performance, small UAS designed and made in Brampton Ontario Canada. The concept was defined in late 2009 and it is designed for a maximum weight of 25 kg which is now the accepted cut-off defining small civil UASs. A very clean tractor propeller layout is used with a lightweight composite structure and a high aspect ratio wing to obtain good range and endurance. The design features and performance of the initial electrically powered version are discussed and progress with developing a multifuel engine version is described. The system includes features enabling operation beyond line of sight (BLOS) and the proving missions are described. The vehicle has been used for aerial photography and low cost mapping using a professional grade Nikon DSLR camera. For forest fire research a FLIR A65 IR camera was used, while for georeferenced mapping a new Applanix AP20 system was calibrated with the Nikon camera. The sorties to be described include forest fire research, wildlife photography of bowhead whales in the Arctic and surveys of endangered caribou in a remote area of Labrador, with all these applications including the DSLR camera.

GNE missense mutation in recessive familial amyotrophic lateral sclerosis.

PubMed

Köroğlu, Çiğdem; Yılmaz, Rezzak; Sorgun, Mine Hayriye; Solakoğlu, Seyhun; Şener, Özden

2017-12-01

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease eventually leading to death from respiratory failure. Recessive inheritance is very rare. Here, we describe the clinical findings in a consanguineous family with five men afflicted with recessive ALS and the identification of the homozygous mutation responsible for the disorder. The onset of the disease ranged from 12 to 35 years of age, with variable disease progressions. We performed clinical investigations including metabolic and paraneoplastic screening, cranial and cervical imaging, and electrophysiology. We mapped the disease gene to 9p21.1-p12 with a LOD score of 5.2 via linkage mapping using genotype data for single-nucleotide polymorphism markers and performed exome sequence analysis to identify the disease-causing gene variant. We also Sanger sequenced all coding sequences of SIGMAR1, a gene reported as responsible for juvenile ALS in a family. We did not find any mutation in SIGMAR1. Instead, we identified a novel homozygous missense mutation p.(His705Arg) in GNE which was predicted as damaging by online tools. GNE has been associated with inclusion body myopathy and is expressed in many tissues. We propose that the GNE mutation underlies the pathology in the family.

An Integrated Tone Mapping for High Dynamic Range Image Visualization

NASA Astrophysics Data System (ADS)

Liang, Lei; Pan, Jeng-Shyang; Zhuang, Yongjun

2018-01-01

There are two type tone mapping operators for high dynamic range (HDR) image visualization. HDR image mapped by perceptual operators have strong sense of reality, but will lose local details. Empirical operators can maximize local detail information of HDR image, but realism is not strong. A common tone mapping operator suitable for all applications is not available. This paper proposes a novel integrated tone mapping framework which can achieve conversion between empirical operators and perceptual operators. In this framework, the empirical operator is rendered based on improved saliency map, which simulates the visual attention mechanism of the human eye to the natural scene. The results of objective evaluation prove the effectiveness of the proposed solution.

Analysis of terrain map matching using multisensing techniques for applications to autonomous vehicle navigation

NASA Technical Reports Server (NTRS)

Page, Lance; Shen, C. N.

1991-01-01

This paper describes skyline-based terrain matching, a new method for locating the vantage point of laser range-finding measurements on a global map previously prepared by satellite or aerial mapping. Skylines can be extracted from the range-finding measurements and modelled from the global map, and are represented in parametric, cylindrical form with azimuth angle as the independent variable. The three translational parameters of the vantage point are determined with a three-dimensional matching of these two sets of skylines.

Cadastral Map Assembling Using Generalized Hough Transformation

NASA Astrophysics Data System (ADS)

Liu, Fei; Ohyama, Wataru; Wakabayashi, Tetsushi; Kimura, Fumitaka

There are numerous cadastral maps generated by the past land surveying. The raster digitization of these paper maps is in progress. For effective and efficient use of these maps, we have to assemble the set of maps to make them superimposable on other geographic information in a GIS. The problem can be seen as a complex jigsaw puzzle where the pieces are the cadastral sections extracted from the map. We present an automatic solution to this geographic jigsaw puzzle, based on the generalized Hough transformation that detects the longest common boundary between every piece and its neighbors. The experiments have been conducted using the map of Mie Prefecture, Japan and the French cadastral map. The results of the experiments with the French cadastral maps showed that the proposed method, which consists of a flood filling procedure of internal area and detection and normalization of the north arrow direction, is suitable for assembling the cadastral map. The final goal of the process is to integrate every piece of the puzzle into a national geographic reference frame and database.

Tularosa Basin Play Fairway Analysis: Partial Basin and Range Heat and Zones of Critical Stress Maps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adam Brandt

Interpolated maps of heat flow, temperature gradient, and quartz geothermometers are included as TIF files. Zones of critical stress map is also included as a TIF file. The zones are given a 5km diameter buffer. The study area is only a part of the Basin and Range, but it does includes the Tularosa Basin.

Molecular subtyping of bladder cancer using Kohonen self-organizing maps.

PubMed

Borkowska, Edyta M; Kruk, Andrzej; Jedrzejczyk, Adam; Rozniecki, Marek; Jablonowski, Zbigniew; Traczyk, Magdalena; Constantinou, Maria; Banaszkiewicz, Monika; Pietrusinski, Michal; Sosnowski, Marek; Hamdy, Freddie C; Peter, Stefan; Catto, James W F; Kaluzewski, Bogdan

2014-10-01

Kohonen self-organizing maps (SOMs) are unsupervised Artificial Neural Networks (ANNs) that are good for low-density data visualization. They easily deal with complex and nonlinear relationships between variables. We evaluated molecular events that characterize high- and low-grade BC pathways in the tumors from 104 patients. We compared the ability of statistical clustering with a SOM to stratify tumors according to the risk of progression to more advanced disease. In univariable analysis, tumor stage (log rank P = 0.006) and grade (P < 0.001), HPV DNA (P < 0.004), Chromosome 9 loss (P = 0.04) and the A148T polymorphism (rs 3731249) in CDKN2A (P = 0.02) were associated with progression. Multivariable analysis of these parameters identified that tumor grade (Cox regression, P = 0.001, OR.2.9 (95% CI 1.6-5.2)) and the presence of HPV DNA (P = 0.017, OR 3.8 (95% CI 1.3-11.4)) were the only independent predictors of progression. Unsupervised hierarchical clustering grouped the tumors into discreet branches but did not stratify according to progression free survival (log rank P = 0.39). These genetic variables were presented to SOM input neurons. SOMs are suitable for complex data integration, allow easy visualization of outcomes, and may stratify BC progression more robustly than hierarchical clustering. © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Report of the Fourth International Workshop on human X chromosome mapping 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlessinger, D.; Mandel, J.L.; Monaco, A.P.

1993-12-31

Vigorous interactive efforts by the X chromosome community have led to accelerated mapping in the last six months. Seventy-five participants from 12 countries around the globe contributed progress reports to the Fourth International X Chromosome Workshop, at St. Louis, MO, May 9-12, 1993. It became clear that well over half the chromosome is now covered by YAC contigs that are being extended, verified, and aligned by their content of STSs and other markers placed by cytogenetic or linkage mapping techniques. The major aim of the workshop was to assemble the consensus map that appears in this report, summarizing both consensusmore » order and YAC contig information.« less

Handbook for MAP, volume 32. Part 1: MAP summary. Part 2: MAPSC minutes, reading, August 1989. MAP summaries from nations. Part 3: MAP data catalogue

NASA Technical Reports Server (NTRS)

Vincent, R. A. (Editor); Edwards, B. (Editor); Hirota, I. (Editor)

1991-01-01

Extended abstracts from the fourth workshop on the technical and scientific aspects of mesosphere stratosphere troposphere (MST) radar are presented. Individual sessions addressed the following topics: meteorological applications of MST and ST radars, networks, and campaigns; the dynamics of the equatorial middle atmosphere; interpretation of radar returns from clear air; techniques for studying gravity waves and turbulence, intercomparison and calibration of wind and wave measurements at various frequencies; progress in existing and planned MST and ST radars; hardware design for MST and ST radars and boundary layer/lower troposphere profilers; signal processing; and data management.

Use of molecular hybridization to explore genetic relationships. Progress report, July 1, 1975--March 31, 1976. [Primates, mice, Drosophila

DOE Office of Scientific and Technical Information (OSTI.GOV)

Atwood, K.C.

Progress is reported on the following research projects: distribution of rDNA in lymphocyte chromosomes of the gibbon; site of 55 DNA in chromosomes of the baboon; satellite associations and rDNA; polymorphisms in rDNA of mouse chromosomes; effect of prephotographing on hybridization; histone and immunoglobulin gene mapping; and rDNA magnification in Drosophila. (HLW)

Precise mapping of annual river bed changes based on airborne laser bathymetry

NASA Astrophysics Data System (ADS)

Mandlburger, Gottfried; Wieser, Martin; Pfeifer, Norbert; Pfennigbauer, Martin; Steinbacher, Frank; Aufleger, Markus

2014-05-01

Airborne Laser Bathymtery (ALB) is a method for capturing relatively shallow water bodies from the air using a pulsed green laser (wavelength=532nm). While this technique was first used for mapping coastal waters only, recent progress in sensor technology has opened the field to apply ALB to running inland waters. Especially for alpine rivers the precise mapping of the channel topography is a challenging task as the flow velocities are often high and the area is difficult and/or dangerous to access by boat or by feet. Traditional mapping techniques like tachymetry or echo sounding fail in such situations while ALB provides, both, high spot position accuracy in the cm range and high spatial resolution in the dm range. Furthermore, state-of-the-art ALB systems allow simultaneous mapping of the river bed and the riparian area and, therefore, represent a comprehensive and efficient technology for mapping the entire floodplain area. The maximum penetration depth depends on, both, water turbidity and bottom reflectivity. Consequently, ALB provides the highest accuracy and resolution over bright gravel rivers with relatively clear water. We demonstrate the capability of ALB for precise mapping of river bed changes based on three flight campaigns in April, May and October 2013 at the River Pielach (Lower Austria) carried out with Riegl's VQ-820-G topo-bathymetric laser scanner. Operated at a flight height of 600m above ground with a pulse repetition rate of 510kHz (effective measurement rate 200kHz) this yielded a mean point spacing within the river bed of 20cm (i.e. point density: 25 points/m2). The positioning accuracy of the river bed points is approx. 2-5cm and depends on the overall ranging precision (20mm), the quality of the water surface model (derived from the ALB point cloud), and the signal intensity (decreasing with water depth). All in all, the obtained point cloud allowed the derivation of a dense grid model of the channel topography (0.25m cell size) for all three epochs constituting an excellent basis for, both, the visual and quantitative estimation of the changes over the year. It turned out that even between the April and May flight remarkable differences could be detected although there was no major precipitation event in-between and the flow conditions were entirely below mean flow. In contrast to the moderate changes between April and May, the flood event in June 2013 (HQ1) resulted in a radical change of the river bed topography documented by the October flight. Since the study site (Neubacher Au) is a Natura2000 conservation area, space for a meandering flow is allowed. Entire gravel bars have been removed and new bars were deposited down-stream. Furthermore, the river axis was locally shifted by more than 1m during the flood event. The results demonstrate the high potential of laser bathymetry for precise mapping of river bed changes. This opens new perspectives for the validation of sediment transport models models and a much better understanding of the river morphology (e.g. formation and changes of sand and gravel banks). The traditional approach in sediment transport modelling based on a limited number of cross sections can be completed respectively replaced by a more comprehensive and more reliable concept on the basis of spatial distributed river bed data. Valuable calibration data in a new quality will be available.

An integrated remote sensing approach for identifying ecological range sites. [parker mountain

NASA Technical Reports Server (NTRS)

Jaynes, R. A.

1983-01-01

A model approach for identifying ecological range sites was applied to high elevation sagebrush-dominated rangelands on Parker Mountain, in south-central Utah. The approach utilizes map information derived from both high altitude color infrared photography and LANDSAT digital data, integrated with soils, geological, and precipitation maps. Identification of the ecological range site for a given area requires an evaluation of all relevant environmental factors which combine to give that site the potential to produce characteristic types and amounts of vegetation. A table is presented which allows the user to determine ecological range site based upon an integrated use of the maps which were prepared. The advantages of identifying ecological range sites through an integrated photo interpretation/LANDSAT analysis are discussed.

Categorizing the severity of paralytic shellfish poisoning outbreaks in the Gulf of Maine for forecasting and management

NASA Astrophysics Data System (ADS)

Kleindinst, Judith L.; Anderson, Donald M.; McGillicuddy, Dennis J.; Stumpf, Richard P.; Fisher, Kathleen M.; Couture, Darcie A.; Michael Hickey, J.; Nash, Christopher

2014-05-01

Development of forecasting systems for harmful algal blooms (HABs) has been a long-standing research and management goal. Significant progress has been made in the Gulf of Maine, where seasonal bloom forecasts are now being issued annually using Alexandrium fundyense cyst abundance maps and a population dynamics model developed for that organism. Thus far, these forecasts have used terms such as “significant”, “moderately large” or “moderate” to convey the extent of forecasted paralytic shellfish poisoning (PSP) outbreaks. In this study, historical shellfish harvesting closure data along the coast of the Gulf of Maine were used to derive a series of bloom severity levels that are analogous to those used to define major storms like hurricanes or tornados. Thirty-four years of PSP-related shellfish closure data for Maine, Massachusetts and New Hampshire were collected and mapped to depict the extent of coastline closure in each year. Due to fractal considerations, different methods were explored for measuring length of coastline closed. Ultimately, a simple procedure was developed using arbitrary straight-line segments to represent specific sections of the coastline. This method was consistently applied to each year’s PSP toxicity closure map to calculate the total length of coastline closed. Maps were then clustered together statistically to yield distinct groups of years with similar characteristics. A series of categories or levels was defined (“Level 1: Limited”, “Level 2: Moderate”, and “Level 3: Extensive”) each with an associated range of expected coastline closed, which can now be used instead of vague descriptors in future forecasts. This will provide scientifically consistent and simply defined information to the public as well as resource managers who make decisions on the basis of the forecasts.

Categorizing the severity of paralytic shellfish poisoning outbreaks in the Gulf of Maine for forecasting and management

PubMed Central

Kleindinst, Judith L.; Anderson, Donald M.; McGillicuddy, Dennis J.; Stumpf, Richard P.; Fisher, Kathleen M.; Couture, Darcie A.; Hickey, J. Michael; Nash, Christopher

2014-01-01

Development of forecasting systems for harmful algal blooms (HABs) has been a long-standing research and management goal. Significant progress has been made in the Gulf of Maine, where seasonal bloom forecasts are now being issued annually using Alexandrium fundyense cyst abundance maps and a population dynamics model developed for that organism. Thus far, these forecasts have used terms such as “significant”, “moderately large” or “moderate” to convey the extent of forecasted paralytic shellfish poisoning (PSP) outbreaks. In this study, historical shellfish harvesting closure data along the coast of the Gulf of Maine were used to derive a series of bloom severity levels that are analogous to those used to define major storms like hurricanes or tornados. Thirty-four years of PSP-related shellfish closure data for Maine, Massachusetts and New Hampshire were collected and mapped to depict the extent of coastline closure in each year. Due to fractal considerations, different methods were explored for measuring length of coastline closed. Ultimately, a simple procedure was developed using arbitrary straight-line segments to represent specific sections of the coastline. This method was consistently applied to each year’s PSP toxicity closure map to calculate the total length of coastline closed. Maps were then clustered together statistically to yield distinct groups of years with similar characteristics. A series of categories or levels was defined (“Level 1: Limited”, “Level 2: Moderate”, and “Level 3: Extensive”) each with an associated range of expected coastline closed, which can now be used instead of vague descriptors in future forecasts. This will provide scientifically consistent and simply defined information to the public as well as resource managers who make decisions on the basis of the forecasts. PMID:25076815

Pediatric awake craniotomy and intra-operative stimulation mapping.

PubMed

Balogun, James A; Khan, Osaama H; Taylor, Michael; Dirks, Peter; Der, Tara; Carter Snead Iii, O; Weiss, Shelly; Ochi, Ayako; Drake, James; Rutka, James T

2014-11-01

The indications for operating on lesions in or near areas of cortical eloquence balance the benefit of resection with the risk of permanent neurological deficit. In adults, awake craniotomy has become a versatile tool in tumor, epilepsy and functional neurosurgery, permitting intra-operative stimulation mapping particularly for language, sensory and motor cortical pathways. This allows for maximal tumor resection with considerable reduction in the risk of post-operative speech and motor deficits. We report our experience of awake craniotomy and cortical stimulation for epilepsy and supratentorial tumors located in and around eloquent areas in a pediatric population (n=10, five females). The presenting symptom was mainly seizures and all children had normal neurological examinations. Neuroimaging showed lesions in the left opercular (n=4) and precentral or peri-sylvian regions (n=6). Three right-sided and seven left-sided awake craniotomies were performed. Two patients had a history of prior craniotomy. All patients had intra-operative mapping for either speech or motor or both using cortical stimulation. The surgical goal for tumor patients was gross total resection, while for all epilepsy procedures, focal cortical resections were completed without any difficulty. None of the patients had permanent post-operative neurologic deficits. The patient with an epileptic focus over the speech area in the left frontal lobe had a mild word finding difficulty post-operatively but this improved progressively. Follow-up ranged from 6 to 27 months. Pediatric awake craniotomy with intra-operative mapping is a precise, safe and reliable method allowing for resection of lesions in eloquent areas. Further validations on larger number of patients will be needed to verify the utility of this technique in the pediatric population. Copyright © 2014 Elsevier Ltd. All rights reserved.

Neo-deterministic seismic hazard scenarios for India—a preventive tool for disaster mitigation

NASA Astrophysics Data System (ADS)

Parvez, Imtiyaz A.; Magrin, Andrea; Vaccari, Franco; Ashish; Mir, Ramees R.; Peresan, Antonella; Panza, Giuliano Francesco

2017-11-01

Current computational resources and physical knowledge of the seismic wave generation and propagation processes allow for reliable numerical and analytical models of waveform generation and propagation. From the simulation of ground motion, it is easy to extract the desired earthquake hazard parameters. Accordingly, a scenario-based approach to seismic hazard assessment has been developed, namely the neo-deterministic seismic hazard assessment (NDSHA), which allows for a wide range of possible seismic sources to be used in the definition of reliable scenarios by means of realistic waveforms modelling. Such reliable and comprehensive characterization of expected earthquake ground motion is essential to improve building codes, particularly for the protection of critical infrastructures and for land use planning. Parvez et al. (Geophys J Int 155:489-508, 2003) published the first ever neo-deterministic seismic hazard map of India by computing synthetic seismograms with input data set consisting of structural models, seismogenic zones, focal mechanisms and earthquake catalogues. As described in Panza et al. (Adv Geophys 53:93-165, 2012), the NDSHA methodology evolved with respect to the original formulation used by Parvez et al. (Geophys J Int 155:489-508, 2003): the computer codes were improved to better fit the need of producing realistic ground shaking maps and ground shaking scenarios, at different scale levels, exploiting the most significant pertinent progresses in data acquisition and modelling. Accordingly, the present study supplies a revised NDSHA map for India. The seismic hazard, expressed in terms of maximum displacement (Dmax), maximum velocity (Vmax) and design ground acceleration (DGA), has been extracted from the synthetic signals and mapped on a regular grid over the studied territory.

Mapping Wintering Waterfowl Distributions Using Weather Surveillance Radar

PubMed Central

Buler, Jeffrey J.; Randall, Lori A.; Fleskes, Joseph P.; Barrow, Wylie C.; Bogart, Tianna; Kluver, Daria

2012-01-01

The current network of weather surveillance radars within the United States readily detects flying birds and has proven to be a useful remote-sensing tool for ornithological study. Radar reflectivity measures serve as an index to bird density and have been used to quantitatively map landbird distributions during migratory stopover by sampling birds aloft at the onset of nocturnal migratory flights. Our objective was to further develop and validate a similar approach for mapping wintering waterfowl distributions using weather surveillance radar observations at the onset of evening flights. We evaluated data from the Sacramento, CA radar (KDAX) during winters 1998–1999 and 1999–2000. We determined an optimal sampling time by evaluating the accuracy and precision of radar observations at different times during the onset of evening flight relative to observed diurnal distributions of radio-marked birds on the ground. The mean time of evening flight initiation occurred 23 min after sunset with the strongest correlations between reflectivity and waterfowl density on the ground occurring almost immediately after flight initiation. Radar measures became more spatially homogeneous as evening flight progressed because birds dispersed from their departure locations. Radars effectively detected birds to a mean maximum range of 83 km during the first 20 min of evening flight. Using a sun elevation angle of −5° (28 min after sunset) as our optimal sampling time, we validated our approach using KDAX data and additional data from the Beale Air Force Base, CA (KBBX) radar during winter 1998–1999. Bias-adjusted radar reflectivity of waterfowl aloft was positively related to the observed diurnal density of radio-marked waterfowl locations on the ground. Thus, weather radars provide accurate measures of relative wintering waterfowl density that can be used to comprehensively map their distributions over large spatial extents. PMID:22911816

Mapping wintering waterfowl distributions using weather surveillance radar.

PubMed

Buler, Jeffrey J; Randall, Lori A; Fleskes, Joseph P; Barrow, Wylie C; Bogart, Tianna; Kluver, Daria

2012-01-01

The current network of weather surveillance radars within the United States readily detects flying birds and has proven to be a useful remote-sensing tool for ornithological study. Radar reflectivity measures serve as an index to bird density and have been used to quantitatively map landbird distributions during migratory stopover by sampling birds aloft at the onset of nocturnal migratory flights. Our objective was to further develop and validate a similar approach for mapping wintering waterfowl distributions using weather surveillance radar observations at the onset of evening flights. We evaluated data from the Sacramento, CA radar (KDAX) during winters 1998-1999 and 1999-2000. We determined an optimal sampling time by evaluating the accuracy and precision of radar observations at different times during the onset of evening flight relative to observed diurnal distributions of radio-marked birds on the ground. The mean time of evening flight initiation occurred 23 min after sunset with the strongest correlations between reflectivity and waterfowl density on the ground occurring almost immediately after flight initiation. Radar measures became more spatially homogeneous as evening flight progressed because birds dispersed from their departure locations. Radars effectively detected birds to a mean maximum range of 83 km during the first 20 min of evening flight. Using a sun elevation angle of -5° (28 min after sunset) as our optimal sampling time, we validated our approach using KDAX data and additional data from the Beale Air Force Base, CA (KBBX) radar during winter 1998-1999. Bias-adjusted radar reflectivity of waterfowl aloft was positively related to the observed diurnal density of radio-marked waterfowl locations on the ground. Thus, weather radars provide accurate measures of relative wintering waterfowl density that can be used to comprehensively map their distributions over large spatial extents.

Botanical and Commercial Range of Tamarack In the Lake States

Treesearch

Paul O. Rudolf

1966-01-01

Accurate maps showing the distribution of important tree species are valuable to foresters, botanists, wildlife specialists, land managers, and others. Although the general natural ranges for our principal tree species have been well known for some time, new information continutes to develop. Commercial ranges, hoever have not previously been mapped precisely, and...

Botanical and Commercial Range of Balsam Fir In the Lake States

Treesearch

Paul O. Rudolf

1966-01-01

Accurate maps showing the distribution of important tree species are valuable to foresters, botanists, wildlife specialists, land managers, and others. Although the general natural ranges for our principal tree species have been well known for some time, new information continues to develop. Commercial ranges, hoever, have not previously been mapped precisely, and...

Human cDNA mapping using fluorescence in situ hybridization. Final progress report, April 1, 1994--July 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korenberg, J.R.

The ultimate goal of this research is to generate and apply novel technologies to speed completion and integration of the human genome map and sequence with biomedical problems. To do this, techniques were developed and genome-wide resources generated. This includes a genome-wide Mapped and Integrated BAC/PAC Resource that has been used for gene finding, map completion and anchoring, breakpoint definition and sequencing. In the last period of the grant, the Human Mapped BAC/PAC Resource was also applied to determine regions of human variation and to develop a novel paradigm of primate evolution through to humans. Further, in order to moremore » rapidly evaluate animal models of human disease, a BAC Map of the mouse was generated in collaboration with the MTI Genome Center, Dr. Bruce Birren.« less

Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women

PubMed Central

Klein, Jenna C.; Schwartz, Christopher E.

2010-01-01

Recent studies report that the menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women. The purpose of the present study was to determine whether oral contraceptives (OC) influence sympathetic neural activation during an orthostatic challenge. Based on evidence that sympathetic baroreflex sensitivity (BRS) is increased during the “low hormone” (LH) phase (i.e., placebo pills) in women taking OC, we hypothesized an augmented muscle sympathetic nerve activity (MSNA) response to orthostatic stress during the LH phase. MSNA, mean arterial pressure (MAP), and heart rate (HR) were recorded during progressive lower body negative pressure (LBNP; −5, −10, −15, −20, −30, −40 mmHg; 3 min/stage) in 12 healthy women taking OC (age 22 ± 1 years). Sympathetic BRS was assessed by examining relations between spontaneous fluctuations of diastolic arterial pressure and MSNA. Subjects were examined twice: once during LH phase and once ∼3 wk after LH during the “high hormone” phase (randomized order). Resting MSNA (10 ± 2 vs. 13 ± 2 bursts/min), MAP (85 ± 3 vs. 84 ± 3 mmHg), and HR (62 ± 2 vs. 65 ± 3 beats/min) were not different between phases. MSNA and HR increased during progressive LBNP (P < 0.001), and these increases were similar between phases. Progressive LBNP did not change MAP during either phase. Sympathetic BRS increased during progressive LBNP, but these responses were not different between LH and high hormone phases. In conclusion, our results demonstrate that OCs do not alter cardiovascular and sympathetic neural responses to an orthostatic challenge in young, healthy women. PMID:19828840

78 FR 21861 - Tribal Consultation on the Draft Regulations Governing the Tribal Transportation Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... regarding the following topics: On July 6, 2012, Moving Ahead for Progress in the 21st Century Act (MAP-21...:30 p.m. May 16, 2013 Phoenix, AZ 9 a.m.-4:30 p.m. May 21, 2013 Minneapolis, MN 9 a.m.-4:30 p.m... President Obama and became effective on October 1, 2012. Section 1119 of MAP-21 struck the existing laws...

United States Air Force Statistical Digest, Fiscal Year 1960. Fifteenth Edition

DTIC Science & Technology

1960-09-30

USAF CIVILIAN EMPLOYEES IN SALARIED AND WAGE BOARD GROUPS EMPLOYED UNDER MILITARY , ASSISTANCE PROGRAM (MAP), AT END OF QUARTER - FY � (Previous year...provide summary data on all aspects of the Mlli_ 165 tary Assistance program administered by the Air Force. The data were compiled from progress reports...Military Assistance . MAP AIRCRAFT - Aircraft in foreign countries provided by the USAF under Military Assistance Program . AIRCRAFT ATTRITION - Aircraft

The other way around: probiotic Lactobacillus acidophilus NP51 restrict progression of Mycobacterium avium subspecies paratuberculosis (MAP) infection in Balb/c mice via activiation of CD8 alpha+ immune cell-mediated immunity

USDA-ARS?s Scientific Manuscript database

The objective of this study was to examine the immune-modulating effects of feeding a novel probiotic Lactobacillus acidophilus strain NP51 to specific pathogen-free Balb/c mice challenged with Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease (JD) in rumi...

The other way around: Probiotic lactobacillus acidophilus NP51 restricts progression of Mycobacterium avium subspecies paratuberculosis (MAP) infection in Balb/c mice through activation of CD8+ T cell-mediated immunity

USDA-ARS?s Scientific Manuscript database

The objective of this study was to examine immune effects of feeding novel probiotic Lactobacillus acidophilus strain NP51 to specific pathogen-free Balb/c mice challenged with Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne’s disease (JD). We hypothesized that fe...

Compositional and volumetric development of a monogenetic lava flow field: The historical case of Paricutin (Michoacán, Mexico)

NASA Astrophysics Data System (ADS)

Larrea, Patricia; Salinas, Sergio; Widom, Elisabeth; Siebe, Claus; Abbitt, Robbyn J. F.

2017-12-01

Paricutin volcano is the youngest and most studied monogenetic volcano in the Michoacán-Guanajuato volcanic field (Mexico), with an excellent historical record of its nine years (February 1943 to March 1952) of eruptive activity. This eruption offered a unique opportunity to observe the birth of a new volcano and document its entire eruption. Geologists surveyed all of the eruptive phases in progress, providing maps depicting the volcano's sequential growth. We have combined all of those previous results and present a new methodological approach, which utilizes state of the art GIS mapping tools to outline and identify the 23 different eruptive phases as originally defined by Luhr and Simkin (1993). Using these detailed lava flow distribution maps, the volume of each of the flows was estimated with the aid of pre- and post-eruption digital elevation models. Our procedure yielded a total lava flow volume ranging between 1.59 and 1.68 km3 DRE, which is larger than previous estimates based on simpler methods. In addition, compositional data allowed us to estimate magma effusion rates and to determine variations in the relative proportions of the different magma compositions issued during the eruption. These results represent the first comprehensive documentation of the combined chemical, temporal, and volumetric evolution of the Paricutin lava field and provide key constraints for petrological interpretations of the nature of the magmatic plumbing system that fed the eruption.

Geology of the Prince William Sound and Kenai Peninsula region, Alaska

USGS Publications Warehouse

Wilson, Frederic H.; Hults, Chad P.

2012-01-01

The Prince William Sound and Kenai Peninsula region includes a significant part of one of the world’s largest accretionary complexes and a small part of the classic magmatic arc geology of the Alaska Peninsula. Physiographically, the map area ranges from the high glaciated mountains of the Alaska and Aleutian Ranges and the Chugach Mountains to the coastal lowlands of Cook Inlet and the Copper River delta. Structurally, the map area is cut by a number of major faults and postulated faults, the most important of which are the Border Ranges, Contact, and Bruin Bay Fault systems. The rocks of the map area belong to the Southern Margin composite terrane, a Tertiary and Cretaceous or older subduction-related accretionary complex, and the Alaska Peninsula terrane. Mesozoic rocks between these two terranes have been variously assigned to the Peninsular or the Hidden terranes. The oldest rocks in the map area are blocks of Paleozoic age within the mélange of the McHugh Complex; however, the protolith age of the greenschist and blueschist within the Border Ranges Fault zone is not known. Extensive glacial deposits mantle the Kenai Peninsula and the lowlands on the west side of Cook Inlet and are locally found elsewhere in the map area. This map was compiled from existing mapping, without generalization, and new or revised data was added where available.

St. Louis Area Earthquake Hazards Mapping Project - A Progress Report-November 2008

USGS Publications Warehouse

Karadeniz, D.; Rogers, J.D.; Williams, R.A.; Cramer, C.H.; Bauer, R.A.; Hoffman, D.; Chung, J.; Hempen, G.L.; Steckel, P.H.; Boyd, O.L.; Watkins, C.M.; McCallister, N.S.; Schweig, E.

2009-01-01

St. Louis has experienced minor earthquake damage at least 12 times in the past 200 years. Because of this history and its proximity to known active earthquake zones, the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) is producing digital maps that show variability of earthquake hazards, including liquefaction and ground shaking, in the St. Louis area. The maps will be available free via the internet. Although not site specific enough to indicate the hazard at a house-by-house resolution, they can be customized by the user to show specific areas of interest, such as neighborhoods or transportation routes. Earthquakes currently cannot be predicted, but scientists can estimate how strongly the ground is likely to shake as the result of an earthquake. Earthquake hazard maps provide one way of conveying such estimates. The U.S. Geological Survey (USGS), which produces earthquake hazard maps for the Nation, is working with local partners to develop detailed maps for urban areas vulnerable to strong ground shaking. These partners, which along with the USGS comprise the SLAEHMP, include the Missouri University of Science and Technology-Rolla (Missouri S&T), Missouri Department of Natural Resources (MDNR), Illinois State Geological Survey (ISGS), Saint Louis University, Missouri State Emergency Management Agency, and URS Corporation. Preliminary hazard maps covering a test portion of the 29-quadrangle St. Louis study area have been produced and are currently being evaluated by the SLAEHMP. A USGS Fact Sheet summarizing this project was produced and almost 1000 copies have been distributed at several public outreach meetings and field trips that have featured the SLAEHMP (Williams and others, 2007). In addition, a USGS website focusing on the SLAEHMP, which provides links to project results and relevant earthquake hazard information, can be found at: http://earthquake.usgs.gov/regional/ceus/urban_map/st_louis/index.php. This progress report summarizes the methodology and data used to generate these preliminary maps. For more details about many of the topics in this summary the reader is referred to the Karadeniz (2007) and Chung (2007) Ph.D. theses.

Cross-disciplinary Undergraduate Research: A Case Study in Digital Mapping, western Ireland

NASA Astrophysics Data System (ADS)

Whitmeyer, S. J.; de Paor, D. G.; Nicoletti, J.; Rivera, M.; Santangelo, B.; Daniels, J.

2008-12-01

As digital mapping technology becomes ever more advanced, field geologists spend a greater proportion of time learning digital methods relative to analyzing rocks and structures. To explore potential solutions to the time commitment implicit in learning digital field methods, we paired James Madison University (JMU) geology majors (experienced in traditional field techniques) with Worcester Polytechnic Institute (WPI) engineering students (experienced in computer applications) during a four week summer mapping project in Connemara, western Ireland. The project consisted of approximately equal parts digital field mapping (directed by the geology students), and lab-based map assembly, evaluation and formatting for virtual 3D terrains (directed by the engineering students). Students collected geologic data in the field using ruggedized handheld computers (Trimble GeoExplorer® series) with ArcPAD® software. Lab work initially focused on building geologic maps in ArcGIS® from the digital field data and then progressed to developing Google Earth-based visualizations of field data and maps. Challenges included exporting GIS data, such as locations and attributes, to KML tags for viewing in Google Earth, which we accomplished using a Linux bash script written by one of our engineers - a task outside the comfort zone of the average geology major. We also attempted to expand the scope of Google Earth by using DEMs of present-day geologically-induced landforms as representative models for paleo-geographic reconstructions of the western Ireland field area. As our integrated approach to digital field work progressed, we found that our digital field mapping produced data at a faster rate than could be effectively managed during our allotted time for lab work. This likely reflected the more developed methodology for digital field data collection, as compared with our lab-based attempts to develop new methods for 3D visualization of geologic maps. However, this experiment in cross-disciplinary undergraduate research was a big success, with an enthusiastic interchange of expertise between undergraduate geology and engineering students that produced new, cutting-edge methods for visualizing geologic data and maps.

Evansville Area Earthquake Hazards Mapping Project (EAEHMP) - Progress Report, 2008

USGS Publications Warehouse

Boyd, Oliver S.; Haase, Jennifer L.; Moore, David W.

2009-01-01

Maps of surficial geology, deterministic and probabilistic seismic hazard, and liquefaction potential index have been prepared by various members of the Evansville Area Earthquake Hazard Mapping Project for seven quadrangles in the Evansville, Indiana, and Henderson, Kentucky, metropolitan areas. The surficial geologic maps feature 23 types of surficial geologic deposits, artificial fill, and undifferentiated bedrock outcrop and include alluvial and lake deposits of the Ohio River valley. Probabilistic and deterministic seismic hazard and liquefaction hazard mapping is made possible by drawing on a wealth of information including surficial geologic maps, water well logs, and in-situ testing profiles using the cone penetration test, standard penetration test, down-hole shear wave velocity tests, and seismic refraction tests. These data were compiled and collected with contributions from the Indiana Geological Survey, Kentucky Geological Survey, Illinois State Geological Survey, United States Geological Survey, and Purdue University. Hazard map products are in progress and are expected to be completed by the end of 2009, with a public roll out in early 2010. Preliminary results suggest that there is a 2 percent probability that peak ground accelerations of about 0.3 g will be exceeded in much of the study area within 50 years, which is similar to the 2002 USGS National Seismic Hazard Maps for a firm rock site value. Accelerations as high as 0.4-0.5 g may be exceeded along the edge of the Ohio River basin. Most of the region outside of the river basin has a low liquefaction potential index (LPI), where the probability that LPI is greater than 5 (that is, there is a high potential for liquefaction) for a M7.7 New Madrid type event is only 20-30 percent. Within the river basin, most of the region has high LPI, where the probability that LPI is greater than 5 for a New Madrid type event is 80-100 percent.

DNCON2: improved protein contact prediction using two-level deep convolutional neural networks.

PubMed

Adhikari, Badri; Hou, Jie; Cheng, Jianlin

2018-05-01

Significant improvements in the prediction of protein residue-residue contacts are observed in the recent years. These contacts, predicted using a variety of coevolution-based and machine learning methods, are the key contributors to the recent progress in ab initio protein structure prediction, as demonstrated in the recent CASP experiments. Continuing the development of new methods to reliably predict contact maps is essential to further improve ab initio structure prediction. In this paper we discuss DNCON2, an improved protein contact map predictor based on two-level deep convolutional neural networks. It consists of six convolutional neural networks-the first five predict contacts at 6, 7.5, 8, 8.5 and 10 Å distance thresholds, and the last one uses these five predictions as additional features to predict final contact maps. On the free-modeling datasets in CASP10, 11 and 12 experiments, DNCON2 achieves mean precisions of 35, 50 and 53.4%, respectively, higher than 30.6% by MetaPSICOV on CASP10 dataset, 34% by MetaPSICOV on CASP11 dataset and 46.3% by Raptor-X on CASP12 dataset, when top L/5 long-range contacts are evaluated. We attribute the improved performance of DNCON2 to the inclusion of short- and medium-range contacts into training, two-level approach to prediction, use of the state-of-the-art optimization and activation functions, and a novel deep learning architecture that allows each filter in a convolutional layer to access all the input features of a protein of arbitrary length. The web server of DNCON2 is at http://sysbio.rnet.missouri.edu/dncon2/ where training and testing datasets as well as the predictions for CASP10, 11 and 12 free-modeling datasets can also be downloaded. Its source code is available at https://github.com/multicom-toolbox/DNCON2/. chengji@missouri.edu. Supplementary data are available at Bioinformatics online.

Forward and backward tone mapping of high dynamic range images based on subband architecture

NASA Astrophysics Data System (ADS)

Bouzidi, Ines; Ouled Zaid, Azza

2015-01-01

This paper presents a novel High Dynamic Range (HDR) tone mapping (TM) system based on sub-band architecture. Standard wavelet filters of Daubechies, Symlets, Coiflets and Biorthogonal were used to estimate the proposed system performance in terms of Low Dynamic Range (LDR) image quality and reconstructed HDR image fidelity. During TM stage, the HDR image is firstly decomposed in sub-bands using symmetrical analysis-synthesis filter bank. The transform coefficients are then rescaled using a predefined gain map. The inverse Tone Mapping (iTM) stage is straightforward. Indeed, the LDR image passes through the same sub-band architecture. But, instead of reducing the dynamic range, the LDR content is boosted to an HDR representation. Moreover, in our TM sheme, we included an optimization module to select the gain map components that minimize the reconstruction error, and consequently resulting in high fidelity HDR content. Comparisons with recent state-of-the-art methods have shown that our method provides better results in terms of visual quality and HDR reconstruction fidelity using objective and subjective evaluations.

Characterization of waste rock associated with acid drainage at the Penn Mine, California, by ground-based visible to short-wave infrared reflectance spectroscopy assisted by digital mapping

USGS Publications Warehouse

Montero, S.I.C.; Brimhall, G.H.; Alpers, Charles N.; Swayze, G.A.

2005-01-01

Prior to remediation at the abandoned Cu-Zn Penn Mine in the Foothills massive sulfide belt of the Sierra Nevada, CA, acid mine drainage (AMD) was created, in part, by the subaerial oxidation of sulfides exposed on several waste piles. To support remediation efforts, a mineralogical study of the waste piles was undertaken by acquiring reflectance spectra (measured in the visible to short-wave infrared range of light (0.35-2.5 ??m) using a portable, digitally integrated pen tablet PC mapping system with differential global positioning system and laser rangefinder support. Analysis of the spectral data made use of a continuum removal and band-shape comparison method, and of reference spectral libraries of end-member minerals and mineral mixtures. Identification of secondary Fe-bearing minerals focused on band matching in the region between 0.43 and 1.3 ??m. Identification of sheet and other silicates was based on band-shape analysis in the region between 1.9 and 2.4 ??m. Analysis of reflectance spectra of characterized rock samples from the mine helped in gauging the spectral response to particle size and mixtures. The resulting mineral maps delineated a pattern of accumulation of secondary Fe minerals, wherein centers of copiapite and jarosite that formed at low pH (<3) were surrounded successively by goethite and hematite, which mark progressive increases in pH. This pattern represents the evolution of acid solutions discharged from the pyritic waste piles and the subsequent accumulation of secondary precipitates by hydrolysis reactions. The results highlight the high capacity of the pyritic waste to release further acid mine drainage into the environment, as well as the effectiveness of the mapping method to detect subtle changes in surface mineralogy and to produce maps useful to agencies responsible for remediating the site. ?? 2004 Elsevier B.V. All rights reserved.

Closing the mycetoma knowledge gap.

PubMed

van de Sande, Wendy; Fahal, Ahmed; Ahmed, Sarah Abdalla; Serrano, Julian Alberto; Bonifaz, Alexandro; Zijlstra, Ed

2018-04-01

On 28th May 2016, mycetoma was recognized as a neglected tropical disease by the World Health Organization. This was the result of a 4-year journey starting in February 2013 with a meeting of global mycetoma experts. Knowledge gaps were identified and included the incidence, prevalence, and mapping of mycetoma; the mode of transmission; the development of methods for early diagnosis; and better treatment. In this review, we review the road to recognition, the ISHAM working group meeting in Argentina, and we address the progress made in closing the knowledge gaps since 2013. Progress included adding another 9000 patients to the literature, which allowed us to update the prevalence map on mycetoma. Furthermore, based on molecular phylogeny, species names were corrected and four novel mycetoma causative agents were identified. By mapping mycetoma causative agents an association with Acacia trees was found. For early diagnosis, three different isothermal amplification techniques were developed, and novel antigens were discovered. To develop better treatment strategies for mycetoma patients, in vitro susceptibility tests for the coelomycete agents of black grain mycetoma were developed, and the first randomized clinical trial for eumycetoma started early 2017.

Facilitating the exploitation of ERTS-1 imagery using snow enhancement techniques. [geological fault maps of Massachusetts and Connecticut

NASA Technical Reports Server (NTRS)

Wobber, F. J. (Principal Investigator); Martin, K. R.; Amato, R. V.; Leshendok, T.

1973-01-01

The author has identified the following significant results. The applications of ERTS-1 imagery for geological fracture mapping regardless of season has been repeatedly confirmed. The enhancement provided by a differential cover of snow increases the number and length of fracture-lineaments which can be detected with ERTS-1 data and accelerates the fracture mapping process for a variety of practical applications. The geological mapping benefits of the program will be realized in geographic areas where data are most needed - complex glaciated terrain and areas of deep residual soils. ERTS-1 derived fracture-lineament maps which provide detail well in excess of existing geological maps are not available in the Massachusetts-Connecticut area. The large quantity of new data provided by ERTS-1 may accelerate and improve field mapping now in progress in the area. Numerous other user groups have requested data on the techniques. This represents a major change in operating philosophy for groups who to data judged that snow obscured geological detail.

Computerized mappings of the cerebral cortex: a multiresolution flattening method and a surface-based coordinate system

NASA Technical Reports Server (NTRS)

Drury, H. A.; Van Essen, D. C.; Anderson, C. H.; Lee, C. W.; Coogan, T. A.; Lewis, J. W.

1996-01-01

We present a new method for generating two-dimensional maps of the cerebral cortex. Our computerized, two-stage flattening method takes as its input any well-defined representation of a surface within the three-dimensional cortex. The first stage rapidly converts this surface to a topologically correct two-dimensional map, without regard for the amount of distortion introduced. The second stage reduces distortions using a multiresolution strategy that makes gross shape changes on a coarsely sampled map and further shape refinements on progressively finer resolution maps. We demonstrate the utility of this approach by creating flat maps of the entire cerebral cortex in the macaque monkey and by displaying various types of experimental data on such maps. We also introduce a surface-based coordinate system that has advantages over conventional stereotaxic coordinates and is relevant to studies of cortical organization in humans as well as non-human primates. Together, these methods provide an improved basis for quantitative studies of individual variability in cortical organization.

GIS Services, Visualization Products, and Interoperability at the National Oceanic and Atmospheric Administration (NOAA) National Climatic Data Center (NCDC)

NASA Astrophysics Data System (ADS)

Baldwin, R.; Ansari, S.; Reid, G.; Lott, N.; Del Greco, S.

2007-12-01

The main goal in developing and deploying Geographic Information System (GIS) services at NOAA's National Climatic Data Center (NCDC) is to provide users with simple access to data archives while integrating new and informative climate products. Several systems at NCDC provide a variety of climatic data in GIS formats and/or map viewers. The Online GIS Map Services provide users with data discovery options which flow into detailed product selection maps, which may be queried using standard "region finder" tools or gazetteer (geographical dictionary search) functions. Each tabbed selection offers steps to help users progress through the systems. A series of additional base map layers or data types have been added to provide companion information. New map services include: Severe Weather Data Inventory, Local Climatological Data, Divisional Data, Global Summary of the Day, and Normals/Extremes products. THREDDS Data Server technology is utilized to provide access to gridded multidimensional datasets such as Model, Satellite and Radar. This access allows users to download data as a gridded NetCDF file, which is readable by ArcGIS. In addition, users may subset the data for a specific geographic region, time period, height range or variable prior to download. The NCDC Weather Radar Toolkit (WRT) is a client tool which accesses Weather Surveillance Radar 1988 Doppler (WSR-88D) data locally or remotely from the NCDC archive, NOAA FTP server or any URL or THREDDS Data Server. The WRT Viewer provides tools for custom data overlays, Web Map Service backgrounds, animations and basic filtering. The export of images and movies is provided in multiple formats. The WRT Data Exporter allows for data export in both vector polygon (Shapefile, Well-Known Text) and raster (GeoTIFF, ESRI Grid, VTK, NetCDF, GrADS) formats. As more users become accustom to GIS, questions of better, cheaper, faster access soon follow. Expanding use and availability can best be accomplished through standards which promote interoperability. Our GIS related products provide Open Geospatial Consortium (OGC) compliant Web Map Services (WMS), Web Feature Services (WFS), Web Coverage Services (WCS) and Federal Geographic Data Committee (FGDC) metadata as a complement to the map viewers. KML/KMZ data files (soon to be compliant OGC specifications) also provide access.

An investigation of extensional tectonics of southern California

NASA Technical Reports Server (NTRS)

Richard, Steven M.; Crowell, John C.

1992-01-01

Geologic mapping and interpretation of Landsat TM imagery has filled in a significant gap in the geologic database for southwestern Arizona and southeastern California. The new data acquired, along with interpretation of existing data, forms the basis for a proposed reconstruction of late Tertiary faults in these regions. This reconstruction integrates available geological and geophysical data to define the eastern limit of deformation related to the San Andreas fault, and has significant implications for other recently proposed reconstructions of Tertiary deformation in the region. This progress in interpreting deformation during the last 10 Ma in the region forms a foundation for developing and testing models of older deformation in this region, including the initiation of San Andreas fault system, and the interaction of Early Miocene extension in the Basin and Range with the evolving San Andreas system.

Geologic Map and Engineering Properties of the Surficial Deposits of the Tok Area, East-Central Alaska

USGS Publications Warehouse

Carrara, Paul E.

2007-01-01

The Tok area 1:100,000-scale map, through which the Alaska Highway runs, is in east-central Alaska about 160 km west of the Yukon border. The surficial geologic mapping in the map area is in support of the 'Geologic Mapping in support of land, resources, and hazards issues in Alaska' Project of the USGS National Cooperative Geologic Mapping Program. The Tok map area contains parts of three physiographic provinces, the Alaska Range, the Yukon-Tanana Upland, and the Northway-Tanana Lowland. The high, rugged, glaciated landscape of the eastern Alaska Range dominates the southwestern map area. The highest peak, an unnamed summit at the head of Cathedral Rapids Creek No. 2, rises to 2166 m. The gently rolling hills of the Yukon-Tanana Upland, in the northern map area, rise to about 1000 m. The Northway-Tanana Lowland contains the valley of the westerly flowing Tanana River. Elevations along the floor of the lowland generally range between 470 and 520 m. The dominant feature within the map is the Tok fan, which occupies about 20 percent of the map area. This large (450 km2), nearly featureless fan contains a high percentage of volcanic clasts derived from outside the present-day drainage of the Tok River. Because the map area is dominated by various surficial deposits, the map depicts 26 different surficial units consisting of man-made, alluvial, colluvial, eolian, lacustrine, organic, glaciofluvial, glacial, and periglacial deposits. The accompanying table provides information concerning the various units including their properties, characteristics, resource potential, and associated hazards in this area of the upper Tanana valley.

Geologic and geophysical maps of the eastern three-fourths of the Cambria 30' x 60' quadrangle, central California Coast Ranges

USGS Publications Warehouse

Graymer, R.W.; Langenheim, V.E.; Roberts, M.A.; McDougall, Kristin

2014-01-01

The Cambria 30´ x 60´ quadrangle comprises southwestern Monterey County and northwestern San Luis Obispo County. The land area includes rugged mountains of the Santa Lucia Range extending from the northwest to the southeast part of the map; the southern part of the Big Sur coast in the northwest; broad marine terraces along the southwest coast; and broadvalleys, rolling hills, and modest mountains in the northeast. This report contains geologic, gravity anomaly, and aeromagnetic anomaly maps of the eastern three-fourths of the 1:100,000-scale Cambria quadrangle and the associated geologic and geophysical databases (ArcMap databases), as well as complete descriptions of the geologic map units and the structural relations in the mapped area. A cross section is based on both the geologic map and potential-field geophysical data. The maps are presented as an interactive, multilayer PDF, rather than more traditional pre-formatted map-sheet PDFs. Various geologic, geophysical, paleontological, and base map elements are placed on separate layers, which allows the user to combine elements interactively to create map views beyond the traditional map sheets. Four traditional map sheets (geologic map, gravity map, aeromagnetic map, paleontological locality map) are easily compiled by choosing the associated data layers or by choosing the desired map under Bookmarks.

Challenges and Opportunities: One Stop Processing of Automatic Large-Scale Base Map Production Using Airborne LIDAR Data Within GIS Environment. Case Study: Makassar City, Indonesia

NASA Astrophysics Data System (ADS)

Widyaningrum, E.; Gorte, B. G. H.

2017-05-01

LiDAR data acquisition is recognized as one of the fastest solutions to provide basis data for large-scale topographical base maps worldwide. Automatic LiDAR processing is believed one possible scheme to accelerate the large-scale topographic base map provision by the Geospatial Information Agency in Indonesia. As a progressive advanced technology, Geographic Information System (GIS) open possibilities to deal with geospatial data automatic processing and analyses. Considering further needs of spatial data sharing and integration, the one stop processing of LiDAR data in a GIS environment is considered a powerful and efficient approach for the base map provision. The quality of the automated topographic base map is assessed and analysed based on its completeness, correctness, quality, and the confusion matrix.

Mapping, fine mapping, and molecular dissection of quantitative trait Loci in domestic animals.

PubMed

Georges, Michel

2007-01-01

Artificial selection has created myriad breeds of domestic animals, each characterized by unique phenotypes pertaining to behavior, morphology, physiology, and disease. Most domestic animal populations share features with isolated founder populations, making them well suited for positional cloning. Genome sequences are now available for most domestic species, and with them a panoply of tools including high-density single-nucleotide polymorphism panels. As a result, domestic animal populations are becoming invaluable resources for studying the molecular architecture of complex traits and of adaptation. Here we review recent progress and issues in the positional identification of genes underlying complex traits in domestic animals. As many phenotypes studied in animals are quantitative, we focus on mapping, fine mapping, and cloning of quantitative trait loci.

Japanese contributions to MAP

NASA Technical Reports Server (NTRS)

Kato, S.

1989-01-01

Japan contributed much to MAP in many branches. The MU (middle and upper atmosphere) radar, in operation during the MAP period, produced various novel possibilities in observations of middle atmosphere dynamics; possibilities which were fairly well realized. Gravity wave saturation and its spectrum in the mesosphere were observed successfully. Campaign observations by radars between Kyoto and Adelaide were especially significant in tidal and planetary wave observations. In Antarctica, middle atmosphere observation of the dramatic behavior of aerosols in winter is well elucidated together with the ozone hole. Theoretical and numerical studies have been progressing actively since a time much earlier than MAP. Now it is pointed out that gravity waves play an important role in producing the weak wind region in the stratosphere as well as the mesosphere.

PCT Databank: A Tool for Planning, Implementation and Monitoring of Integrated Preventive Chemotherapy for Control of Neglected Tropical Diseases (NTD)

PubMed Central

Mikhailov, Alexei; Yajima, Aya; Mbabazi, PS; Gabrielli, Albis F.; Montresor, Antonio; Engels, Dirk

2017-01-01

The integration of vertical control programmes of neglected tropical diseases (NTDs) aims at containing operational cost, simplifies the application of the control measures and extends the intervention coverage. The Preventive Chemotherapy and Transmission Control (PCT) Databank was established by the World Health Organization to facilitate the sharing of data among the different partners involved in control activities and collects and compiles historical and current information on disease-specific epidemiological situation, the geographical overlapping of NTDs and the progress of control activities in all the NTD-endemic countries. The summary of country-specific epidemiological maps and the progress of control activities is available online as the online PCT Databank and Country Profiles. The annual progress of preventive chemotherapy (PC) interventions targeting at specific NTDs is also annually reported in the Weekly Epidemiological Record (WER). In this paper, we elucidated the methodology of data collection, compilation and mapping to establish the PCT Databank and presented the key features of the associated three online outputs, i.e. the online PCT Databank, the Country Profile and the WER. PMID:22357399

Surficial Geologic Map of the Death Valley Junction 30' x 60' Quadrangle, California and Nevada

USGS Publications Warehouse

Slate, Janet L.; Berry, Margaret E.; Menges, Christopher M.

2009-01-01

This surficial geologic map of the Death Valley Junction 30' x 60' quadrangle was compiled digitally at 1:100,000 scale. The map area covers the central part of Death Valley and adjacent mountain ranges - the Panamint Range on the west and the Funeral Mountains on the east - as well as areas east of Death Valley including some of the Amargosa Desert, the Spring Mountains and Pahrump Valley. Shaded relief delineates the topography and appears as gray tones in the mountain ranges where the bedrock is undifferentiated and depicted as a single unit.

Preliminary Geologic Map of the Mount Hood 30- by 60-minute Quadrangle, Northern Cascade Range, Oregon

USGS Publications Warehouse

Sherrod, David R.; Scott, William E.

1995-01-01

This map shows the geology of the central and eastern parts of the Cascade Range in northern Oregon. The Quaternary andesitic stratovolcano of Mount Hood dominates the northwest quarter of the quadrangle, but nearly the entire area is underlain by arc-related volcanic and volcaniclastic rocks of the Cascade Range. Most stratigraphic units were emplaced since middle Miocene time, and all are Oligocene or younger. Despite the proximity of the map area to the Portland metropolitan area, large parts remained virtually unstudied or known only from limited reconnaissance until the late 1970s. A notable exception is the area surrounding Mount Hood, where mapping and chemical analyses by Wise (1969) provided a framework for geologic interpretation. Mapping since 1975 was conducted first to understand the stratigraphy and structure of the Columbia River Basalt Group (Anderson, 1978; Vogt, 1981; J.L. Anderson, in Swanson and others, 1981; Vandiver-Powell, 1978; Burck, 1986) and later to examine the geothermal potential of Mount Hood (Priest and others, 1982). Additional mapping was completed in 1985 for a geologic map of the Cascade Range in Oregon (Sherrod and Smith, 1989). From 1987 to 1990, detailed mapping was conducted in three 15-minute quadrangles on a limited basis (D.R. Sherrod, unpublished mapping) (see fig. 1 for index to mapping). An ongoing volcanic hazards study of Mount Hood by the U.S. Geological Survey (Scott and others, 1994) has provided the catalyst for completing the geologic map of the Mount Hood 30-minute by 60-minute quadrangle. As of June 1994, only two broad areas still remain largely unmapped. One of these areas, labeled 'unmapped' on the geologic map, lies in the Salmon River valley south of Zigzag along the west margin of the quadrangle. Although strata of the Columbia River Basalt Group in the Salmon River valley were mapped in detail by Burck (1986), the overlying middle and upper(?) Miocene lava flows, volcaniclastic strata, and intrusions have never been studied. The other poorly known area, the Mutton Mountains in the southeastern part of the map area, consists of Oligocene and lower Miocene volcanic and volcaniclastic rocks. Overlying lava flows of the Columbia River Basalt Group were mapped in some detail by Anderson (in Swanson and others, 1981).

Preliminary bedrock geologic map of part of the northern disturbed belt, Lewis and Clark, Teton, Pondera, Glacier, Flathead, and Powell Counties, Montana

USGS Publications Warehouse

Mudge, Melville R.; Earhart, Robert L.; Rice, Dudley D.; Heisey, E.L.

1977-01-01

The geologic map covers the Sawtooth and Lewis and Clark Ranges and part of the Flathead Range. It includes most of the disturbed belt in northwestern Moutana except the area east of the northern Rocky Mountains and the norhtern and southern parts of the belt. Most data are from an unpublished map of the Bob Marshall Wilderness and of the many proposed additions to the Wilderness. Strike and dip symbols are omitted from the map, and all contacts are shown in solid lines, alhough locally they are inferred beneath a Quaternary cover. Future studies will complete mapping of the northern disturbed belt in Montana.

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome.

PubMed

Spurrell, Cailyn H; Dickel, Diane E; Visel, Axel

2016-11-17

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters. Copyright © 2016 Elsevier Inc. All rights reserved.

XMM Observations of Low Mass Groups

NASA Technical Reports Server (NTRS)

Davis, David S.

2005-01-01

The contents of this report contains discussion of the two-dimensional XMM-Newton group survey. The analysis of the NGC 2300 and Pavo observations indicated by the azimuthally averaged analysis that the temperature structure is minimal to the NGC2300 system; however, the Pavo system shows signs of a merger in progress. XMM data is used to generate two dimensional maps of the temperature and abundance used to generate maps of pressure and entropy.

Modeling and Prediction of Wildfire Hazard in Southern California, Integration of Models with Imaging Spectrometry

NASA Technical Reports Server (NTRS)

Roberts, Dar A.; Church, Richard; Ustin, Susan L.; Brass, James A. (Technical Monitor)

2001-01-01

Large urban wildfires throughout southern California have caused billions of dollars of damage and significant loss of life over the last few decades. Rapid urban growth along the wildland interface, high fuel loads and a potential increase in the frequency of large fires due to climatic change suggest that the problem will worsen in the future. Improved fire spread prediction and reduced uncertainty in assessing fire hazard would be significant, both economically and socially. Current problems in the modeling of fire spread include the role of plant community differences, spatial heterogeneity in fuels and spatio-temporal changes in fuels. In this research, we evaluated the potential of Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) and Airborne Synthetic Aperture Radar (AIRSAR) data for providing improved maps of wildfire fuel properties. Analysis concentrated in two areas of Southern California, the Santa Monica Mountains and Santa Barbara Front Range. Wildfire fuel information can be divided into four basic categories: fuel type, fuel load (live green and woody biomass), fuel moisture and fuel condition (live vs senesced fuels). To map fuel type, AVIRIS data were used to map vegetation species using Multiple Endmember Spectral Mixture Analysis (MESMA) and Binary Decision Trees. Green live biomass and canopy moisture were mapped using AVIRIS through analysis of the 980 nm liquid water absorption feature and compared to alternate measures of moisture and field measurements. Woody biomass was mapped using L and P band cross polarimetric data acquired in 1998 and 1999. Fuel condition was mapped using spectral mixture analysis to map green vegetation (green leaves), nonphotosynthetic vegetation (NPV; stems, wood and litter), shade and soil. Summaries describing the potential of hyperspectral and SAR data for fuel mapping are provided by Roberts et al. and Dennison et al. To utilize remotely sensed data to assess fire hazard, fuel-type maps were translated into standard fuel models accessible to the FARSITE fire spread simulator. The FARSITE model and BEHAVE are considered industry standards for fire behavior analysis. Anderson level fuels map, generated using a binary decision tree classifier are available for multiple dates in the Santa Monica Mountains and at least one date for Santa Barbara. Fuel maps that will fill in the areas between Santa Barbara and the Santa Monica Mountains study sites are in progress, as part of a NASA Regional Earth Science Application Center, the Southern California Wildfire Hazard Center. Species-level maps, were supplied to fire managing agencies (Los Angeles County Fire, California Department of Forestry). Research results were published extensively in the refereed and non-refereed literature. Educational outreach included funding of several graduate students, undergraduate intern training and an article featured in the California Alliance for Minorities Program (CAMP) Quarterly Journal.

Geologic map of the Reyes Peak quadrangle, Ventura County, California

USGS Publications Warehouse

Minor, Scott A.

2004-01-01

New 1:24,000-scale geologic mapping in the Cuyama 30' x 60' quadrangle, in support of the USGS Southern California Areal Mapping Project (SCAMP), is contributing to a more complete understanding of the stratigraphy, structure, and tectonic evolution of the complex junction area between the NW-trending Coast Ranges and EW-trending western Transverse Ranges. The 1:24,000-scale geologic map of the Reyes Peak quadrangle, located in the eastern part of the Cuyama map area, is the final of six contiguous 7 ?' quadrangle geologic maps compiled for a more detailed portrayal and reevaluation of geologic structures and rock units shown on previous maps of the region (Carman, 1964; Dibblee, 1972; Vedder and others, 1973). SCAMP digital geologic maps of the five other contiguous quadrangles have recently been published (Minor, 1999; Kellogg, 1999, 2003; Stone and Cossette, 2000; Kellogg and Miggins, 2002). This digital compilation presents a new geologic map database for the Reyes Peak 7?' quadrangle, which is located in southern California about 75 km northwest of Los Angeles. The map database is at 1:24,000-scale resolution.

Geologic Map of the Eaton Reservoir Quadrangle, Larimer County, Colorado and Albany County, Wyoming

USGS Publications Warehouse

Workman, Jeremiah B.

2008-01-01

New geologic mapping of the Eaton Reservoir 7.5' quadrangle defines geologic relationships in the northern Front Range along the Colorado/Wyoming border approximately 35 km south of Laramie, Wyo. Previous mapping within the quadrangle was limited to regional reconnaissance mapping (Tweto, 1979; Camp, 1979; Burch, 1983) and some minor site-specific studies (Carlson and Marsh, 1986; W. Braddock, unpub. mapping, 1982). Braddock and others (1989) mapped the Diamond Peak 7.5' quadrangle to the east, Burch (1983) mapped rocks of the Rawah batholith to the south, W. Braddock (unpub. mapping, 1981) mapped the Sand Creek Pass 7.5' quadrangle to the west, and Ver Ploeg and Boyd (2000) mapped the Laramie 30' x 60' quadrangle to the north. Field work was completed during 2005 and 2006 and the mapping was compiled at a scale of 1:24,000. Minimal petrographic work and isotope dating was done in connection with the present mapping, but detailed petrographic and isotope studies were carried out on correlative map units in surrounding areas as part of a related regional study of the northern Front Range. Classification of Proterozoic rocks is primarily based upon field observation of bulk mineral composition, macroscopic textural features, and field relationships that allow for correlation with rocks studied in greater detail outside of the map area.

Fracture of a Brittle-Particle Ductile Matrix Composite with Applications to a Coating System

NASA Astrophysics Data System (ADS)

Bianculli, Steven J.

In material systems consisting of hard second phase particles in a ductile matrix, failure initiating from cracking of the second phase particles is an important failure mechanism. This dissertation applies the principles of fracture mechanics to consider this problem, first from the standpoint of fracture of the particles, and then the onset of crack propagation from fractured particles. This research was inspired by the observation of the failure mechanism of a commercial zinc-based anti-corrosion coating and the analysis was initially approached as coatings problem. As the work progressed it became evident that failure mechanism was relevant to a broad range of composite material systems and research approach was generalized to consider failure of a system consisting of ellipsoidal second phase particles in a ductile matrix. The starting point for the analysis is the classical Eshelby Problem, which considered stress transfer from the matrix to an ellipsoidal inclusion. The particle fracture problem is approached by considering cracks within particles and how they are affected by the particle/matrix interface, the difference in properties between the particle and matrix, and by particle shape. These effects are mapped out for a wide range of material combinations. The trends developed show that, although the particle fracture problem is very complex, the potential for fracture among a range of particle shapes can, for certain ranges in particle shape, be considered easily on the basis of the Eshelby Stress alone. Additionally, the evaluation of cracks near the curved particle/matrix interface adds to the existing body of work of cracks approaching bi-material interfaces in layered material systems. The onset of crack propagation from fractured particles is then considered as a function of particle shape and mismatch in material properties between the particle and matrix. This behavior is mapped out for a wide range of material combinations. The final section of this dissertation qualitatively considers an approach to determine critical particle sizes, below which crack propagation will not occur for a coating system that exhibited stable cracks in an interfacial layer between the coating and substrate.

Geologic Map of Lassen Volcanic National Park and Vicinity, California

USGS Publications Warehouse

Clynne, Michael A.; Muffler, L.J. Patrick

2010-01-01

The geologic map of Lassen Volcanic National Park (LVNP) and vicinity encompasses 1,905 km2 at the south end of the Cascade Range in Shasta, Lassen, Tehama, and Plumas Counties, northeastern California (fig. 1, sheet 3). The park includes 430 km2 of scenic volcanic features, glacially sculpted terrain, and the most spectacular array of thermal features in the Cascade Range. Interest in preserving the scenic wonders of the Lassen area as a national park arose in the early 1900s to protect it from commercial development and led to the establishment in 1907 of two small national monuments centered on Lassen Peak and Cinder Cone. The eruptions of Lassen Peak in 1914-15 were the first in the Cascade Range since widespread settling of the West in the late 1800s. Through the printed media, the eruptions aroused considerable public interest and inspired renewed efforts, which had languished since 1907, to establish a national park. In 1916, Lassen Volcanic National Park was established by combining the areas of the previously established national monuments and adjacent lands. The southernmost Cascade Range is bounded on the west by the Sacramento Valley and the Klamath Mountains, on the south by the Sierra Nevada, and on the east by the Basin and Range geologic provinces. Most of the map area is underlain by middle to late Pleistocene volcanic rocks; Holocene, early Pleistocene, and late Pliocene volcanic rocks (<3.5 m.y.) are less common. Paleozoic and Mesozoic rocks are inferred to underlie the volcanic deposits (Jachens and Saltus, 1983), but the nearest exposures of pre-Tertiary rocks are 15 km to the south, 9 km to the southwest, and 12 km to the west. Diller (1895) recognized the young volcanic geology and produced the first geologic map of the Lassen area. The map (sheet 1) builds on and extends geologic mapping by Williams (1932), Macdonald (1963, 1964, 1965), and Wilson (1961). The Lassen Peak area mapped by Christiansen and others (2002) and published in greater detail (1:24,000) was modified for inclusion here. Figure 2 (sheet 3) shows the mapping credit for previous work; figure 3 (sheet 3) shows locations discussed throughout the text. A CD-ROM entitled Database for the Geologic Map of Lassen Volcanic National Park and Vicinity, California accompanies the printed map (Muffler and others, 2010). The CD-ROM contains ESRI compatible geographic information system data files used to create the 1:50,000-scale geologic map, both geologic and topographic data and their associated metadata files, and printable versions of the geologic map and pamphlet as PDF formatted files. The 1:50,000-scale geologic map was compiled from 1:24,000-scale geologic maps of individual quadrangles that are also included in the CD-ROM. It also contains ancillary data that support the map including locations of rock samples selected for chemical analysis (Clynne and others, 2008) and radiometric dating, photographs of geologic features, and links to related data or web sites. Data contained in the CD-ROM are also available on this Web site. The southernmost Cascade Range consists of a regional platform of basalt and basaltic andesite, with subordinate andesite and sparse dacite. Nested within these regional rocks are 'volcanic centers', defined as large, long-lived, composite, calc-alkaline edifices erupting the full range of compositions from basalt to rhyolite, but dominated by andesite and dacite. Volcanic centers are produced by the focusing of basaltic flux from the mantle and resultant enhanced interaction of mafic magma with the crust. Collectively, volcanic centers mark the axis of the southernmost Cascade Range. The map area includes the entire Lassen Volcanic Center, parts of three older volcanic centers (Maidu, Dittmar, and Latour), and the products of regional volcanism (fig. 4, sheet 3). Terminology used for subdivision of the Lassen Volcanic Center has been modified from Clynne (1984, 1990).

Antarctic sea ice thickness data archival and recovery at the Australian Antarctic Data Centre

NASA Astrophysics Data System (ADS)

Worby, A. P.; Treverrow, A.; Raymond, B.; Jordan, M.

2007-12-01

A new effort is underway to establish a portal for Antarctic sea ice thickness data at the Australian Antarctic Data Centre (http://aadc-maps.aad.gov.au/aadc/sitd/). The intention is to provide a central online access point for a wide range of sea ice data sets, including sea ice and snow thickness data collected using a range of techniques, and sea ice core data. The recommendation to establish this facility came from the SCAR/CliC- sponsored International Workshop on Antarctic Sea Ice Thickness, held in Hobart in July 2006. It was recognised, in particular, that satellite altimetry retrievals of sea ice and snow cover thickness rely on large-scale assumptions of the sea ice and snow cover properties such as density, freeboard height, and snow stratigraphy. The synthesis of historical data is therefore particularly important for algorithm development. This will be closely coordinated with similar efforts in the Arctic. A small working group was formed to identify suitable data sets for inclusion in the archive. A series of standard proformas have been designed for converting old data, and to help standardize the collection of new data sets. These proformas are being trialled on two Antarctic sea ice research cruises in September - October 2007. The web-based portal allows data custodians to remotely upload and manage their data, and for all users to search the holdings and extract data relevant to their needs. This presentation will report on the establishment of the data portal, recent progress in identifying appropriate data sets and making them available online. maps.aad.gov.au/aadc/sitd/

A joint estimation detection of Glaucoma progression in 3D spectral domain optical coherence tomography optic nerve head images

NASA Astrophysics Data System (ADS)

Belghith, Akram; Bowd, Christopher; Weinreb, Robert N.; Zangwill, Linda M.

2014-03-01

Glaucoma is an ocular disease characterized by distinctive changes in the optic nerve head (ONH) and visual field. Glaucoma can strike without symptoms and causes blindness if it remains without treatment. Therefore, early disease detection is important so that treatment can be initiated and blindness prevented. In this context, important advances in technology for non-invasive imaging of the eye have been made providing quantitative tools to measure structural changes in ONH topography, an essential element for glaucoma detection and monitoring. 3D spectral domain optical coherence tomography (SD-OCT), an optical imaging technique, has been commonly used to discriminate glaucomatous from healthy subjects. In this paper, we present a new framework for detection of glaucoma progression using 3D SD-OCT images. In contrast to previous works that the retinal nerve fiber layer (RNFL) thickness measurement provided by commercially available spectral-domain optical coherence tomograph, we consider the whole 3D volume for change detection. To integrate a priori knowledge and in particular the spatial voxel dependency in the change detection map, we propose the use of the Markov Random Field to handle a such dependency. To accommodate the presence of false positive detection, the estimated change detection map is then used to classify a 3D SDOCT image into the "non-progressing" and "progressing" glaucoma classes, based on a fuzzy logic classifier. We compared the diagnostic performance of the proposed framework to existing methods of progression detection.

Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens.

PubMed

Uttam, Shikhar; Pham, Hoa V; LaFace, Justin; Leibowitz, Brian; Yu, Jian; Brand, Randall E; Hartman, Douglas J; Liu, Yang

2015-11-15

Early cancer detection currently relies on screening the entire at-risk population, as with colonoscopy and mammography. Therefore, frequent, invasive surveillance of patients at risk for developing cancer carries financial, physical, and emotional burdens because clinicians lack tools to accurately predict which patients will actually progress into malignancy. Here, we present a new method to predict cancer progression risk via nanoscale nuclear architecture mapping (nanoNAM) of unstained tissue sections based on the intrinsic density alteration of nuclear structure rather than the amount of stain uptake. We demonstrate that nanoNAM detects a gradual increase in the density alteration of nuclear architecture during malignant transformation in animal models of colon carcinogenesis and in human patients with ulcerative colitis, even in tissue that appears histologically normal according to pathologists. We evaluated the ability of nanoNAM to predict "future" cancer progression in patients with ulcerative colitis who did and did not develop colon cancer up to 13 years after their initial colonoscopy. NanoNAM of the initial biopsies correctly classified 12 of 15 patients who eventually developed colon cancer and 15 of 18 who did not, with an overall accuracy of 85%. Taken together, our findings demonstrate great potential for nanoNAM in predicting cancer progression risk and suggest that further validation in a multicenter study with larger cohorts may eventually advance this method to become a routine clinical test. ©2015 American Association for Cancer Research.

A joint estimation detection of Glaucoma progression in 3D spectral domain optical coherence tomography optic nerve head images.

PubMed

Belghith, Akram; Bowd, Christopher; Weinreb, Robert N; Zangwill, Linda M

2014-03-18

Glaucoma is an ocular disease characterized by distinctive changes in the optic nerve head (ONH) and visual field. Glaucoma can strike without symptoms and causes blindness if it remains without treatment. Therefore, early disease detection is important so that treatment can be initiated and blindness prevented. In this context, important advances in technology for non-invasive imaging of the eye have been made providing quantitative tools to measure structural changes in ONH topography, an essential element for glaucoma detection and monitoring. 3D spectral domain optical coherence tomography (SD-OCT), an optical imaging technique, has been commonly used to discriminate glaucomatous from healthy subjects. In this paper, we present a new framework for detection of glaucoma progression using 3D SD-OCT images. In contrast to previous works that the retinal nerve fiber layer (RNFL) thickness measurement provided by commercially available spectral-domain optical coherence tomograph, we consider the whole 3D volume for change detection. To integrate a priori knowledge and in particular the spatial voxel dependency in the change detection map, we propose the use of the Markov Random Field to handle a such dependency. To accommodate the presence of false positive detection, the estimated change detection map is then used to classify a 3D SDOCT image into the "non-progressing" and "progressing" glaucoma classes, based on a fuzzy logic classifier. We compared the diagnostic performance of the proposed framework to existing methods of progression detection.

Strategic plan for geriatrics and extended care in the veterans health administration: background, plan, and progress to date.

PubMed

Shay, Kenneth; Hyduke, Barbara; Burris, James F

2013-04-01

The leaders of Geriatrics and Extended Care (GEC) in the Veterans Health Administration (VHA) undertook a strategic planning process that led to approval in 2009 of a multidisciplinary, evidence-guided strategic plan. This article reviews the four goals contained in that plan and describes VHA's progress in addressing them. The goals included transforming the healthcare system to a veteran-centric approach, achieving universal access to a panel of services, ensuring that the Veterans Affair's (VA) healthcare workforce was adequately prepared to manage the needs of the growing elderly veteran population, and integrating continuous improvement into all care enhancements. There has been substantial progress in addressing all four goals. All VHA health care has undergone an extensive transformation to patient-centered care, has enriched the services it can offer caregivers of dependent veterans, and has instituted models to better integrate VA and non-VA cares and services. A range of successful models of geriatric care described in the professional literature has been adapted to VA environments to gauge suitability for broader implementation. An executive-level task force developed a three-pronged approach for enhancing the VA's geriatric workforce. The VHA's performance measurement approaches increasingly include incentives to enhance the quality of management of vulnerable elderly adults in primary care. The GEC strategic plan was intended to serve as a road map for keeping VHA aligned with an ambitious but important long-term vision for GEC services. Although no discrete set of resources was appropriated for fulfillment of the plan's recommendations, this initial report reflects substantial progress in addressing most of its goals. © 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.

Progress in NTHMP Hazard Assessment

USGS Publications Warehouse

Gonzalez, F.I.; Titov, V.V.; Mofjeld, H.O.; Venturato, A.J.; Simmons, R.S.; Hansen, R.; Combellick, Rodney; Eisner, R.K.; Hoirup, D.F.; Yanagi, B.S.; Yong, S.; Darienzo, M.; Priest, G.R.; Crawford, G.L.; Walsh, T.J.

2005-01-01

The Hazard Assessment component of the U.S. National Tsunami Hazard Mitigation Program has completed 22 modeling efforts covering 113 coastal communities with an estimated population of 1.2 million residents that are at risk. Twenty-three evacuation maps have also been completed. Important improvements in organizational structure have been made with the addition of two State geotechnical agency representatives to Steering Group membership, and progress has been made on other improvements suggested by program reviewers. ?? Springer 2005.

Resource Needs and Pedagogical Value of Web Mapping for Spatial Thinking

ERIC Educational Resources Information Center

Manson, Steven; Shannon, Jerry; Eria, Sami; Kne, Len; Dyke, Kevin; Nelson, Sara; Batra, Lalit; Bonsal, Dudley; Kernik, Melinda; Immich, Jennifer; Matson, Laura

2014-01-01

Web mapping involves publishing and using maps via the Internet, and can range from presenting static maps to offering dynamic data querying and spatial analysis. Web mapping is seen as a promising way to support development of spatial thinking in the classroom but there are unanswered questions about how this promise plays out in reality. This…

Development of Competence and Performance in Cartographic Language by Children at the Concrete Level of Map-Reasoning.

ERIC Educational Resources Information Center

Gerber, Rodney Victor

This dissertation examines development of children's skills at map using and free-recall map sketching, with particular emphasis on map reasoning, competence in cartographic language, and performance in cartographic language. Cartographic language (the broad range of line, point, and area signs and map elements) is interpreted as the means by…

Case study of rotating sonar sensor application in unmanned automated guided vehicle

NASA Astrophysics Data System (ADS)

Chandak, Pravin; Cao, Ming; Hall, Ernest L.

2001-10-01

A single rotating sonar element is used with a restricted angle of sweep to obtain readings to develop a range map for the unobstructed path of an autonomous guided vehicle (AGV). A Polaroid ultrasound transducer element is mounted on a micromotor with an encoder feedback. The motion of this motor is controlled using a Galil DMC 1000 motion control board. The encoder is interfaced with the DMC 1000 board using an intermediate IMC 1100 break-out board. By adjusting the parameters of the Polaroid element, it is possible to obtain range readings at known angles with respect to the center of the robot. The readings are mapped to obtain a range map of the unobstructed path in front of the robot. The idea can be extended to a 360 degree mapping by changing the assembly level programming on the Galil Motion control board. Such a system would be compact and reliable over a range of environments and AGV applications.

Mapping the Journal of Homosexuality: A Preface.

PubMed

Wahlert, Lance

2016-01-01

This article serves as a Preface to the supplementary section of this special issue on "Mapping Queer Bioethics," in which we take a solipsistic turn to "map" the Journal of Homosexuality itself. Born contemporaneously with the depathologization of "homosexuality" in the early 1970s, how does the Journal of Homosexuality's commitment to LGBT health issues the past four decades reveal longstanding tensions between medical pathology, cultural appropriation, and political progress? Introducing the articles that follow (each of which examines a seminal medical-themed subject from the journal's history), this article asks how LGBT-sensitive academic texts play complicit roles in both the reinforcement and the liberation of queer subjects in biomedical discourse.

Electromagnetic wave method for mapping subterranean earth formations

DOEpatents

Shuck, Lowell Z.; Fasching, George E.; Balanis, Constantine A.

1977-01-01

The present invention is directed to a method for remotely mapping subterranean coal beds prior to and during in situ gasification operations. This method is achieved by emplacing highly directional electromagnetic wave transmitters and receivers in bore holes penetrating the coal beds and then mapping the anomalies surrounding each bore hole by selectively rotating and vertically displacing the directional transmitter in a transmitting mode within the bore hole, and thereafter, initiating the gasification of the coal at bore holes separate from those containing the transmitters and receivers and then utilizing the latter for monitoring the burn front as it progresses toward the transmitters and receivers.

Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for Tectonic and Volcanic History of the North Polar Region of Venus

NASA Technical Reports Server (NTRS)

Hurwitz, D. M.; Head, J. W.

2009-01-01

Geologic mapping of Snegurochka Planitia (V-1) reveals a complex stratigraphy of tectonic and volcanic features that can provide insight into the geologic history of Venus and Archean Earth [1,2], including 1) episodes of both localized crustal uplift and mantle downwelling, 2) shifts from local to regional volcanic activity, and 3) a shift back to local volcanic activity. We present our progress in mapping the spatial and stratigraphic relationships of material units and our initial interpretations of the tectonic and volcanic history of the region surrounding the north pole of Venus

Pilot Study of Gleevec/Imatinib Mesylate (STI 571, NSC 716051) in Neurofibromatosis (NF1) Patients with Plexiform Neurofibromas

DTIC Science & Technology

2016-03-01

increase in certain circulating cytokines reflected tumors that progress. This study’s cytokine assay employed the MilliPlex map Human Cytokine...receptors were assayed using MILLIPLEX MAP Human Soluble Cytokine Receptor Panel (cat# HSCRMAG-32K) and included: sCD30, sgp130, sIL-1RI, sIL-1RII, sIL-2Rα...sIL-4R, sIL-6R, sRAGE, sTNFRI, sTNFRII, sVEGF-R1, sVEGF-R2, sVEGF-R3. Separately were run TGF β 1, TGF β 2, and TGF β 3 using the MILLIPLEX MAP

Seismic Line Location Map Hot Pot Project, Humboldt County, Nevada 2010

DOE Data Explorer

Lane, Michael

2010-01-01

Seismic Line Location Map Hot Pot Project, Humboldt County, Nevada 2010. ArcGIS map package containing topographic base map, Township and Range layer, Oski BLM and private leases at time of survey, and locations, with selected shot points, of the five seismic lines.

Database for the geologic map of upper Eocene to Holocene volcanic and related rocks in the Cascade Range, Washington

USGS Publications Warehouse

Barron, Andrew D.; Ramsey, David W.; Smith, James G.

2014-01-01

This digital database contains information used to produce the geologic map published as Sheet 1 in U.S. Geological Survey Miscellaneous Investigations Series Map I-2005. (Sheet 2 of Map I-2005 shows sources of geologic data used in the compilation and is available separately). Sheet 1 of Map I-2005 shows the distribution and relations of volcanic and related rock units in the Cascade Range of Washington at a scale of 1:500,000. This digital release is produced from stable materials originally compiled at 1:250,000 scale that were used to publish Sheet 1. The database therefore contains more detailed geologic information than is portrayed on Sheet 1. This is most noticeable in the database as expanded polygons of surficial units and the presence of additional strands of concealed faults. No stable compilation materials exist for Sheet 1 at 1:500,000 scale. The main component of this digital release is a spatial database prepared using geographic information systems (GIS) applications. This release also contains links to files to view or print the map sheet, main report text, and accompanying mapping reference sheet from Map I-2005. For more information on volcanoes in the Cascade Range in Washington, Oregon, or California, please refer to the U.S. Geological Survey Volcano Hazards Program website.

An integrated molecular cytogenetic map of Cucumis sativus L. chromosome 2.

PubMed

Han, Yonghua; Zhang, Zhonghua; Huang, Sanwen; Jin, Weiwei

2011-01-27

Integration of molecular, genetic and cytological maps is still a challenge for most plant species. Recent progress in molecular and cytogenetic studies created a basis for developing integrated maps in cucumber (Cucumis sativus L.). In this study, eleven fosmid clones and three plasmids containing 45S rDNA, the centromeric satellite repeat Type III and the pericentriomeric repeat CsRP1 sequences respectively were hybridized to cucumber metaphase chromosomes to assign their cytological location on chromosome 2. Moreover, an integrated molecular cytogenetic map of cucumber chromosomes 2 was constructed by fluorescence in situ hybridization (FISH) mapping of 11 fosmid clones together with the cucumber centromere-specific Type III sequence on meiotic pachytene chromosomes. The cytogenetic map was fully integrated with genetic linkage map since each fosmid clone was anchored by a genetically mapped simple sequence repeat marker (SSR). The relationship between the genetic and physical distances along chromosome was analyzed. Recombination was not evenly distributed along the physical length of chromosome 2. Suppression of recombination was found in centromeric and pericentromeric regions. Our results also indicated that the molecular markers composing the linkage map for chromosome 2 provided excellent coverage of the chromosome.

A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation

PubMed Central

Mogessie, Binyam; Roth, Daniel; Rahil, Zainab; Straube, Anne

2015-01-01

The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation. In this study, we identify a previously uncharacterised isoform of microtubule-associated protein MAP4, oMAP4, as a microtubule organising factor that is crucial for myogenesis. We show that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme. Depletion of oMAP4 impairs cell elongation and cell–cell fusion. Most notably, oMAP4 is required for paraxial microtubule organisation in muscle cells and prevents dynein- and kinesin-driven microtubule–microtubule sliding. Purified oMAP4 aligns dynamic microtubules into antiparallel bundles that withstand motor forces in vitro. We propose a model in which the cooperation of dynein-mediated microtubule transport and oMAP4-mediated zippering of microtubules drives formation of a paraxial microtubule array that provides critical support for the polarisation and elongation of myotubes. DOI: http://dx.doi.org/10.7554/eLife.05697.001 PMID:25898002

The use of process mapping in healthcare quality improvement projects.

PubMed

Antonacci, Grazia; Reed, Julie E; Lennox, Laura; Barlow, James

2018-05-01

Introduction Process mapping provides insight into systems and processes in which improvement interventions are introduced and is seen as useful in healthcare quality improvement projects. There is little empirical evidence on the use of process mapping in healthcare practice. This study advances understanding of the benefits and success factors of process mapping within quality improvement projects. Methods Eight quality improvement projects were purposively selected from different healthcare settings within the UK's National Health Service. Data were gathered from multiple data-sources, including interviews exploring participants' experience of using process mapping in their projects and perceptions of benefits and challenges related to its use. These were analysed using inductive analysis. Results Eight key benefits related to process mapping use were reported by participants (gathering a shared understanding of the reality; identifying improvement opportunities; engaging stakeholders in the project; defining project's objectives; monitoring project progress; learning; increased empathy; simplicity of the method) and five factors related to successful process mapping exercises (simple and appropriate visual representation, information gathered from multiple stakeholders, facilitator's experience and soft skills, basic training, iterative use of process mapping throughout the project). Conclusions Findings highlight benefits and versatility of process mapping and provide practical suggestions to improve its use in practice.

Infrasound and the avian navigational map

USGS Publications Warehouse

Hagstrum, J.T.

2001-01-01

Birds can accurately navigate over hundreds to thousands of kilometres, and use celestial and magnetic compass senses to orient their flight. How birds determine their location in order to select the correct homeward bearing (map sense) remains controversial, and has been attributed to their olfactory or magnetic senses. Pigeons can hear infrasound down to 0??05 Hz, and an acoustic avian map is proposed consisting of infrasonic cues radiated from steep-sided topographic features. The source of these infrasonic signals is microseisms continuously generated by interfering oceanic waves. Atmospheric processes affecting the infrasonic map cues can explain perplexing experimental results from pigeon releases. Moreover, four recent disrupted pigeon races in Europe and the north-eastern USA intersected infrasonic shock waves from the Concorde supersonic transport. Having an acoustic map might also allow clock-shifted birds to test their homeward progress and select between their magnetic and solar compasses.

Mapping coastal vegetation, land use and environmental impact from ERTS-1. [Delaware Bay area

NASA Technical Reports Server (NTRS)

Klemas, V. (Principal Investigator)

1973-01-01

The author has identified the following significant results. Vegetation map overlays at a scale of 1:24,000 compiled by multispectral analysis from NASA aircraft imagery for all of Delaware's wetlands are being used as ground truth for ERTS-1 mapping and by state agencies for wetlands management. Six major vegetation species were discriminated and mapped, including percentages of minor species. Analogue enhancements of wetlands vegetation and dredge-fill operations have been produced using General Electric's GEMS data processing and ERTS-1 false color composites. Digital, thematic land use, and vegetation mapping of entire Delaware Bay area is in progress using Bendix Corporation's Earth Resources Data System and ERTS-1 digital tapes. Statistical evaluation of target-group selection reliability has been completed. Three papers have been published on ERTS-1 coastal vegetation and land use. Local and state officials are participating in the ERTS-1 program as co-investigators.

Infrared and visible image fusion method based on saliency detection in sparse domain

NASA Astrophysics Data System (ADS)

Liu, C. H.; Qi, Y.; Ding, W. R.

2017-06-01

Infrared and visible image fusion is a key problem in the field of multi-sensor image fusion. To better preserve the significant information of the infrared and visible images in the final fused image, the saliency maps of the source images is introduced into the fusion procedure. Firstly, under the framework of the joint sparse representation (JSR) model, the global and local saliency maps of the source images are obtained based on sparse coefficients. Then, a saliency detection model is proposed, which combines the global and local saliency maps to generate an integrated saliency map. Finally, a weighted fusion algorithm based on the integrated saliency map is developed to achieve the fusion progress. The experimental results show that our method is superior to the state-of-the-art methods in terms of several universal quality evaluation indexes, as well as in the visual quality.

Geologic map of the east half of the Lime Hills 1:250,000-scale quadrangle, Alaska

USGS Publications Warehouse

Gamble, Bruce M.; Reed, Bruce L.; Richter, Donald H.; Lanphere, Marvin A.

2013-01-01

This map is compiled from geologic mapping conducted between 1985 and 1992 by the U.S. Geological Survey as part of the Alaska Mineral Resource Assessment Program. That mapping built upon previous USGS work (1963–1988) unraveling the magmatic history of the Alaska–Aleutian Range batholith. Quaternary unit contacts depicted on this map are derived largely from aerial-photograph interpretation. K-Ar ages made prior to this study have been recalculated using 1977 decay constants. The east half of the Lime Hills 1:250,000-scale quadrangle includes part of the Alaska–Aleutian Range batholith and several sequences of sedimentary rocks or mixed sedimentary and volcanic rocks. The Alaska–Aleutian Range batholith contains rocks that represent three major igneous episodes, (1) Early and Middle Jurassic, (2) Late Cretaceous and early Tertiary, and (3) middle Tertiary; only rocks from the latter two episodes are found in this map area. The map area is one of very steep and rugged terrain; elevations range from a little under 1,000 ft (305 m) to 9,828 ft (2,996 m). Foot traverses are generally restricted to lowermost elevations. Areas suitable for helicopter landings can be scarce at higher elevations. Most of the area was mapped from the air, supplemented by direct examination of rocks where possible. This restricted access greatly complicates understanding some of the more complex geologic units. For example, we know there are plutons whose compositions vary from gabbro to granodiorite, but we have little insight as to how these phases are distributed and what their relations might be to each other. It is also possible that some of what we have described as compositionally complex plutons might actually be several distinct intrusions.

Bedrock geologic map of the northern Alaska Peninsula area, southwestern Alaska

USGS Publications Warehouse

Wilson, Frederic H.; Blodgett, Robert B.; Blome, Charles D.; Mohadjer, Solmaz; Preller, Cindi C.; Klimasauskas, Edward P.; Gamble, Bruce M.; Coonrad, Warren L.

2017-03-03

The northern Alaska Peninsula is a region of transition from the classic magmatic arc geology of the Alaska Peninsula to a Proterozoic and early Paleozoic carbonate platform and then to the poorly understood, tectonically complex sedimentary basins of southwestern Alaska. Physiographically, the region ranges from the high glaciated mountains of the Alaska-Aleutian Range to the coastal lowlands of Cook Inlet on the east and Bristol Bay on the southwest. The lower Ahklun Mountains and finger lakes on the west side of the map area show strong effects from glaciation. Structurally, a number of major faults cut the map area. Most important of these are the Bruin Bay Fault that parallels the coast of Cook Inlet, the Lake Clark Fault that cuts diagonally northeast to southwest across the eastern part of the map area, and the presently active Holitna Fault to the northwest that cuts surficial deposits.Distinctive rock packages assigned to three provinces are overlain by younger sedimentary rocks and intruded by widely dispersed latest Cretaceous and (or) early Tertiary granitic rocks. Much of the east half of the map area lies in the Alaska-Aleutian Range province; the Jurassic to Tertiary Alaska-Aleutian Range batholith and derivative Jurassic sedimentary rocks form the core of this province, which is intruded and overlain by the Aleutian magmatic arc. The Lime Hills province, the carbonate platform, occurs in the north-central part of the map area. The Paleozoic and Mesozoic Ahklun Mountains province in the western part of the map area includes abundant chert, argillite, and graywacke and lesser limestone, basalt, and tectonic mélange. The Kuskokwim Group, an Upper Cretaceous turbidite sequence, is extensively exposed and bounds all three provinces in the west-central part of the map area.

Neutron Scattering and the 30 S Ribosomal Subunit of E. Coli

DOE R&D Accomplishments Database

Moore, P. B.; Engelman, D. M.; Langer, J. A.; Ramakrishnan, V. R.; Schindler, D. G.; Schoenborn, B. P.; Sillers, I. Y.; Yabuki, S.

1982-06-01

This paper reviews the progress made in the study of the internal organization of the 30 S ribosomal subunit of E. coli by neutron scattering since 1975. A map of that particle showing the position of 14 of the subunit's 21 proteins is presented, and the methods currently used for collecting and analyzing such data are discussed. Also discussed is the possibility of extending the interpretation of neutron mapping data beyond the limits practical today.

Engineering web maps with gradual content zoom based on streaming vector data

NASA Astrophysics Data System (ADS)

Huang, Lina; Meijers, Martijn; Šuba, Radan; van Oosterom, Peter

2016-04-01

Vario-scale data structures have been designed to support gradual content zoom and the progressive transfer of vector data, for use with arbitrary map scales. The focus to date has been on the server side, especially on how to convert geographic data into the proposed vario-scale structures by means of automated generalisation. This paper contributes to the ongoing vario-scale research by focusing on the client side and communication, particularly on how this works in a web-services setting. It is claimed that these functionalities are urgently needed, as many web-based applications, both desktop and mobile, require gradual content zoom, progressive transfer and a high performance level. The web-client prototypes developed in this paper make it possible to assess the behaviour of vario-scale data and to determine how users will actually see the interactions. Several different options of web-services communication architectures are possible in a vario-scale setting. These options are analysed and tested with various web-client prototypes, with respect to functionality, ease of implementation and performance (amount of transmitted data and response times). We show that the vario-scale data structure can fit in with current web-based architectures and efforts to standardise map distribution on the internet. However, to maximise the benefits of vario-scale data, a client needs to be aware of this structure. When a client needs a map to be refined (by means of a gradual content zoom operation), only the 'missing' data will be requested. This data will be sent incrementally to the client from a server. In this way, the amount of data transferred at one time is reduced, shortening the transmission time. In addition to these conceptual architecture aspects, there are many implementation and tooling design decisions at play. These will also be elaborated on in this paper. Based on the experiments conducted, we conclude that the vario-scale approach indeed supports gradual content zoom and the progressive web transfer of vector data. This is a big step forward in making vector data at arbitrary map scales available to larger user groups.

Use of incentives to encourage ITS deployment.

DOT National Transportation Integrated Search

2014-07-01

Moving Ahead for Progress in the 21st Century Act (MAP-21) identifies Intelligent Transportation Systems (ITS) as part of the solution to the Nations transportation needs and provides mechanisms for accelerating deployment of innovative technology...

Geologic map of the Sand Creek Pass quadrangle, Larimer County, Colorado, and Albany County, Wyoming

USGS Publications Warehouse

Workman, Jeremiah B.; Braddock, William A.

2010-01-01

New geologic mapping within the Sand Creek Pass 7.5 minute quadrangle defines geologic relationships within the northern Front Range of Colorado along the Wyoming border approximately 35 km south of Laramie, Wyo. Previous mapping within the quadrangle was limited to regional reconnaissance mapping; Eaton Reservoir 7.5 minute quadrangle to the east (2008), granite of the Rawah batholith to the south (1983), Laramie River valley to the west (1979), and the Laramie 30' x 60' quadrangle to the north (2007). Fieldwork was completed during 1981 and 1982 and during 2007 and 2008. Mapping was compiled at 1:24,000-scale. Minimal petrographic work was done and no isotope work was done in the quadrangle area, but detailed petrographic and isotope studies were performed on correlative map units in surrounding areas as part of a related regional study of the northern Front Range. Stratigraphy of Proterozoic rocks is primarily based upon field observation of bulk mineral composition, macroscopic textural features, and field relationships that allow for correlation with rocks studied in greater detail outside of the map area. Stratigraphy of Phanerozoic rocks is primarily based upon correlation with similar rocks to the north in the Laramie Basin of Wyoming and to the east in the Front Range of Colorado.

Mapping copy number variation by population-scale genome sequencing.

PubMed

Mills, Ryan E; Walter, Klaudia; Stewart, Chip; Handsaker, Robert E; Chen, Ken; Alkan, Can; Abyzov, Alexej; Yoon, Seungtai Chris; Ye, Kai; Cheetham, R Keira; Chinwalla, Asif; Conrad, Donald F; Fu, Yutao; Grubert, Fabian; Hajirasouliha, Iman; Hormozdiari, Fereydoun; Iakoucheva, Lilia M; Iqbal, Zamin; Kang, Shuli; Kidd, Jeffrey M; Konkel, Miriam K; Korn, Joshua; Khurana, Ekta; Kural, Deniz; Lam, Hugo Y K; Leng, Jing; Li, Ruiqiang; Li, Yingrui; Lin, Chang-Yun; Luo, Ruibang; Mu, Xinmeng Jasmine; Nemesh, James; Peckham, Heather E; Rausch, Tobias; Scally, Aylwyn; Shi, Xinghua; Stromberg, Michael P; Stütz, Adrian M; Urban, Alexander Eckehart; Walker, Jerilyn A; Wu, Jiantao; Zhang, Yujun; Zhang, Zhengdong D; Batzer, Mark A; Ding, Li; Marth, Gabor T; McVean, Gil; Sebat, Jonathan; Snyder, Michael; Wang, Jun; Ye, Kenny; Eichler, Evan E; Gerstein, Mark B; Hurles, Matthew E; Lee, Charles; McCarroll, Steven A; Korbel, Jan O

2011-02-03

Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of most SVs remains unknown. We constructed a map of unbalanced SVs (that is, copy number variants) based on whole genome DNA sequencing data from 185 human genomes, integrating evidence from complementary SV discovery approaches with extensive experimental validations. Our map encompassed 22,025 deletions and 6,000 additional SVs, including insertions and tandem duplications. Most SVs (53%) were mapped to nucleotide resolution, which facilitated analysing their origin and functional impact. We examined numerous whole and partial gene deletions with a genotyping approach and observed a depletion of gene disruptions amongst high frequency deletions. Furthermore, we observed differences in the size spectra of SVs originating from distinct formation mechanisms, and constructed a map of SV hotspots formed by common mechanisms. Our analytical framework and SV map serves as a resource for sequencing-based association studies.

Correlation of physical and genetic maps of human chromosome 16. Annual progress report, October 1, 1990--July 31, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutherland, G.R.

1991-12-31

This project aimed to divide chromosome 16 into approximately 50 intervals of {approximately}2Mb in size by constructing a series of mouse/human somatic cell hybrids each containing a rearranged chromosome 16. Using these hybrids, DNA probes would be regionally mapped by Southern blot or PCR analysis. Preference would be given to mapping probes which demonstrated polymorphisms for which the CEPH panel of families had been typed. This would allow a correlation of the physical and linkage maps of this chromosome. The aims have been substantially achieved. 49 somatic cell hybrids have been constructed which have allowed definition of 46, and potentiallymore » 57, different physical intervals on the chromosome. 164 loci have been fully mapped into these intervals. A correlation of the physical and genetic maps of the chromosome is in an advanced stage of preparation. The somatic cell hybrids constructed have been widely distributed to groups working on chromosome 16 and other genome projects.« less

Integrated landscape-based approach of remote sensing, GIS, and physical modelling to study the hydrological connectivity of wetlands to the downstream water: progress and challenge

NASA Astrophysics Data System (ADS)

Yeo, I. Y.

2015-12-01

We report the recent progress on our effort to improve the mapping of wetland dynamics and the modelling of its functioning and hydrological connection to the downstream waters. Our study focused on the Coastal Plain of the Chesapeake Bay Watershed (CBW), the Delmarva Peninsula, where the most of wetlands in CBW are densely distributed. The wetland ecosystem plays crucial roles in improving water quality and ecological integrity for the downstream waters and the Chesapeake Bay, and headwater wetlands in the region, such as Delmarva Bay, are now subject to the legal protection under the Clean Water Rules. We developed new wetland maps using time series Landsat images and a highly accurate LiDAR map over last 30 years. These maps show the changes in surface water fraction at a 30-m grid cell at annual time scale. Using GIS, we analyse these maps to characterize changing dynamics of wetland inundation due to the physical environmental factors (e.g., weather variability, tide) and assessed the hydrological connection of wetlands to the downstream water at the watershed scale. Focusing on the two adjacent watersheds in the upper region of the Choptank River Basin, we study how wetland inundation dynamics and the hydrologic linkage of wetlands to downstream water would vary by the local hydrogeological setting and attempt to identify the key landscape factors affecting the wetland ecosystems and functioning. We then discuss the potential of using remote sensing products to improve the physical modelling of wetlands from our experience with SWAT (Soil and Water Assessment Tool).

Milestones: Critical Elements in Clinical Informatics Fellowship Programs

PubMed Central

Lehmann, Christoph U.; Munger, Benson

2016-01-01

Summary Background Milestones refer to points along a continuum of a competency from novice to expert. Resident and fellow assessment and program evaluation processes adopted by the ACGME include the mandate that programs report the educational progress of residents and fellows twice annually utilizing Milestones developed by a specialty specific ACGME working group of experts. Milestones in clinical training programs are largely unmapped to specific assessment tools. Residents and fellows are mainly assessed using locally derived assessment instruments. These assessments are then reviewed by the Clinical Competency Committee which assigns and reports trainee ratings using the specialty specific reporting Milestones. Methods and Results The challenge and opportunity facing the nascent specialty of Clinical Informatics is how to optimally utilize this framework across a growing number of accredited fellowships. The authors review how a mapped milestone framework, in which each required sub-competency is mapped to a single milestone assessment grid, can enable the use of milestones for multiple uses including individualized learning plans, fellow assessments, and program evaluation. Furthermore, such a mapped strategy will foster the ability to compare fellow progress within and between Clinical Informatics Fellowships in a structured and reliable fashion. Clinical Informatics currently has far less variability across programs and thus could easily utilize a more tightly defined set of milestones with a clear mapping to sub-competencies. This approach would enable greater standardization of assessment instruments and processes across programs while allowing for variability in how those sub-competencies are taught. Conclusions A mapped strategy for Milestones offers significant advantages for Clinical Informatics programs. PMID:27081414

The Release 6 reference sequence of the Drosophila melanogaster genome

DOE PAGES

Hoskins, Roger A.; Carlson, Joseph W.; Wan, Kenneth H.; ...

2015-01-14

Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial reference genome sequence reported more than a decade ago had a profound impact on progress in Drosophila research, and improving the accuracy and completeness of this sequence continues to be important to further progress. We previously described improvement of the 117-Mb sequence in the euchromatic portion of the genome and 21 Mb in the heterochromatic portion, using a whole-genome shotgun assembly, BAC physical mapping, and clone-based finishing. Here, we report an improved reference sequence of the single-copy andmore » middle-repetitive regions of the genome, produced using cytogenetic mapping to mitotic and polytene chromosomes, clone-based finishing and BAC fingerprint verification, ordering of scaffolds by alignment to cDNA sequences, incorporation of other map and sequence data, and validation by whole-genome optical restriction mapping. These data substantially improve the accuracy and completeness of the reference sequence and the order and orientation of sequence scaffolds into chromosome arm assemblies. Representation of the Y chromosome and other heterochromatic regions is particularly improved. The new 143.9-Mb reference sequence, designated Release 6, effectively exhausts clone-based technologies for mapping and sequencing. Highly repeat-rich regions, including large satellite blocks and functional elements such as the ribosomal RNA genes and the centromeres, are largely inaccessible to current sequencing and assembly methods and remain poorly represented. In conclusion, further significant improvements will require sequencing technologies that do not depend on molecular cloning and that produce very long reads.« less

The Release 6 reference sequence of the Drosophila melanogaster genome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoskins, Roger A.; Carlson, Joseph W.; Wan, Kenneth H.

Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial reference genome sequence reported more than a decade ago had a profound impact on progress in Drosophila research, and improving the accuracy and completeness of this sequence continues to be important to further progress. We previously described improvement of the 117-Mb sequence in the euchromatic portion of the genome and 21 Mb in the heterochromatic portion, using a whole-genome shotgun assembly, BAC physical mapping, and clone-based finishing. Here, we report an improved reference sequence of the single-copy andmore » middle-repetitive regions of the genome, produced using cytogenetic mapping to mitotic and polytene chromosomes, clone-based finishing and BAC fingerprint verification, ordering of scaffolds by alignment to cDNA sequences, incorporation of other map and sequence data, and validation by whole-genome optical restriction mapping. These data substantially improve the accuracy and completeness of the reference sequence and the order and orientation of sequence scaffolds into chromosome arm assemblies. Representation of the Y chromosome and other heterochromatic regions is particularly improved. The new 143.9-Mb reference sequence, designated Release 6, effectively exhausts clone-based technologies for mapping and sequencing. Highly repeat-rich regions, including large satellite blocks and functional elements such as the ribosomal RNA genes and the centromeres, are largely inaccessible to current sequencing and assembly methods and remain poorly represented. In conclusion, further significant improvements will require sequencing technologies that do not depend on molecular cloning and that produce very long reads.« less

Micro-Mechanical Modeling of Ductile Fracture in Welded Aluminum-Lithium Alloys

NASA Technical Reports Server (NTRS)

Ibrahim, Ahmed

2002-01-01

This computation model for microscopic crack growth in welded aluminum-lithium alloys consists of a cavity with initial volume specified by the fraction f(sub 0), i.e. the void volume relative to the cell volume. Thus, cell size D and initial porosity f(sub 0) defines the key parameters in this model. The choice of cell size requires: 1) D must be representative of the large inclusion spacing. 2) Predicted R-curves scale almost proportionally with D for fixed f(sub 0). 3) mapping of one finite element per cell must provide adequate resolution of the stress-strain fields in the active layer and the adjacent material. For the ferritic steels studied thus far with this model, calibrated cell sizes range from 50-200 microns with f(sub 0) in the 0.0001 to 0.004 micron range. This range of values for D and f (sub 0) satisfies issues 1) and 3). This computational model employs the Gurson and Tvergaard constitutive model for porous plastic materials to describe the progressive damage of cells due to the growth of pre-existing voids. The model derives from a rigid-plastic limit analysis of a solid having a volume fraction (f) of voids approximated by a homogenous spherical body containing a spherical void.

The next generation Antarctic digital magnetic anomaly map

USGS Publications Warehouse

von Frese, R.R.B; Golynsky, A.V.; Kim, H.R.; Gaya-Piqué, L.; Thébault, E.; Chiappinii, M.; Ghidella, M.; Grunow, A.; ,

2007-01-01

S (Golynsky et al., 2001). This map synthesized over 7.1 million line-kms of survey data available up through 1999 from marine, airborne and Magsat satellite observations. Since the production of the initial map, a large number of new marine and airborne surveys and improved magnetic observations from the Ørsted and CHAMP satellite missions have become available. In addition, an improved core field model for the Antarctic has been developed to better isolate crustal anomalies in these data. The next generation compilation also will likely represent the magnetic survey observations of the region in terms of a high-resolution spherical cap harmonic model. In this paper, we review the progress and problems of developing an improved magnetic anomaly map to facilitate studies of the Antarctic crustal magnetic field

Clinical resistance associated with a novel MAP2K1 mutation in a patient with Langerhans cell histiocytosis.

PubMed

Azorsa, David O; Lee, David W; Wai, Daniel H; Bista, Ranjan; Patel, Apurvi R; Aleem, Eiman; Henry, Michael M; Arceci, Robert J

2018-05-16

Patients with Langerhans cell histiocytosis (LCH) harbor BRAF V600E and activating mutations of MAP2K1/MEK1 in 50% and 25% of cases, respectively. We evaluated a patient with treatment-refractory LCH for mutations in the RAS-RAF-MEK-ERK pathway and identified a novel mutation in the MAP2K1 gene resulting in a p.L98_K104 > Q deletion and predicted to be auto-activating. During treatment with the MEK inhibitor trametinib, the patient's disease showed significant progression. In vitro characterization of the MAP2K1 p.L98_K104 > Q deletion confirmed its effect on cellular activation of the ERK pathway and drug resistance. © 2018 Wiley Periodicals, Inc.

DNA nanomapping using CRISPR-Cas9 as a programmable nanoparticle.

PubMed

Mikheikin, Andrey; Olsen, Anita; Leslie, Kevin; Russell-Pavier, Freddie; Yacoot, Andrew; Picco, Loren; Payton, Oliver; Toor, Amir; Chesney, Alden; Gimzewski, James K; Mishra, Bud; Reed, Jason

2017-11-21

Progress in whole-genome sequencing using short-read (e.g., <150 bp), next-generation sequencing technologies has reinvigorated interest in high-resolution physical mapping to fill technical gaps that are not well addressed by sequencing. Here, we report two technical advances in DNA nanotechnology and single-molecule genomics: (1) we describe a labeling technique (CRISPR-Cas9 nanoparticles) for high-speed AFM-based physical mapping of DNA and (2) the first successful demonstration of using DVD optics to image DNA molecules with high-speed AFM. As a proof of principle, we used this new "nanomapping" method to detect and map precisely BCL2-IGH translocations present in lymph node biopsies of follicular lymphoma patents. This HS-AFM "nanomapping" technique can be complementary to both sequencing and other physical mapping approaches.

Agriculture and nutrition in India: mapping evidence to pathways.

PubMed

Kadiyala, Suneetha; Harris, Jody; Headey, Derek; Yosef, Sivan; Gillespie, Stuart

2014-12-01

In India, progress against undernutrition has been slow. Given its importance for income generation, improving diets, care practices, and maternal health, the agriculture sector is widely regarded as playing an important role in accelerating the reduction in undernutrition. This paper comprehensively maps existing evidence along agriculture-nutrition pathways in India and assesses both the quality and coverage of the existing literature. We present a conceptual framework delineating six key pathways between agriculture and nutrition. Three pathways pertain to the nutritional impacts of farm production, farm incomes, and food prices. The other three pertain to agriculture-gender linkages. After an extensive search, we found 78 research papers that provided evidence to populate these pathways. The literature suggests that Indian agriculture has a range of important influences on nutrition. Agriculture seems to influence diets even when controlling for income, and relative food prices could partly explain observed dietary changes in recent decades. The evidence on agriculture-gender linkages to nutrition is relatively weak. Sizeable knowledge gaps remain. The root causes of these gaps include an interdisciplinary disconnect between nutrition and economics/agriculture, a related problem of inadequate survey data, and limited policy-driven experimentation. Closing these gaps is essential to strengthening the agriculture sector's contribution to reducing undernutrition. © 2014 New York Academy of Sciences.

Spatial frequency domain spectroscopy of two layer media

NASA Astrophysics Data System (ADS)

Yudovsky, Dmitry; Durkin, Anthony J.

2011-10-01

Monitoring of tissue blood volume and oxygen saturation using biomedical optics techniques has the potential to inform the assessment of tissue health, healing, and dysfunction. These quantities are typically estimated from the contribution of oxyhemoglobin and deoxyhemoglobin to the absorption spectrum of the dermis. However, estimation of blood related absorption in superficial tissue such as the skin can be confounded by the strong absorption of melanin in the epidermis. Furthermore, epidermal thickness and pigmentation varies with anatomic location, race, gender, and degree of disease progression. This study describes a technique for decoupling the effect of melanin absorption in the epidermis from blood absorption in the dermis for a large range of skin types and thicknesses. An artificial neural network was used to map input optical properties to spatial frequency domain diffuse reflectance of two layer media. Then, iterative fitting was used to determine the optical properties from simulated spatial frequency domain diffuse reflectance. Additionally, an artificial neural network was trained to directly map spatial frequency domain reflectance to sets of optical properties of a two layer medium, thus bypassing the need for iteration. In both cases, the optical thickness of the epidermis and absorption and reduced scattering coefficients of the dermis were determined independently. The accuracy and efficiency of the iterative fitting approach was compared with the direct neural network inversion.

Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks

PubMed Central

Brandon, Mark P; Koenig, Julie; Leutgeb, Stefan

2014-01-01

The brain is able to construct internal representations that correspond to external spatial coordinates. Such brain maps of the external spatial topography may support a number of cognitive functions, including navigation and memory. The neuronal building block of brain maps are place cells, which are found throughout the hippocampus of rodents and, in a lower proportion, primates. Place cells typically fire in one or few restricted areas of space, and each area where a cell fires can range, along the dorsoventral axis of the hippocampus, from 30 cm to at least several meters. The sensory processing streams that give rise to hippocampal place cells are not fully understood, but substantial progress has been made in characterizing the entorhinal cortex, which is the gateway between neocortical areas and the hippocampus. Entorhinal neurons have diverse spatial firing characteristics, and the different entorhinal cell types converge in the hippocampus to give rise to a single, spatially modulated cell type—the place cell. We therefore suggest that parallel information processing in different classes of cells—as is typically observed at lower levels of sensory processing—continues up into higher level association cortices, including those that provide the inputs to hippocampus. WIREs Cogn Sci 2014, 5:207–219. doi: 10.1002/wcs.1272 PMID:24587849

Mobile robot sense net

NASA Astrophysics Data System (ADS)

Konolige, Kurt G.; Gutmann, Steffen; Guzzoni, Didier; Ficklin, Robert W.; Nicewarner, Keith E.

1999-08-01

Mobile robot hardware and software is developing to the point where interesting applications for groups of such robots can be contemplated. We envision a set of mobots acting to map and perform surveillance or other task within an indoor environment (the Sense Net). A typical application of the Sense Net would be to detect survivors in buildings damaged by earthquake or other disaster, where human searchers would be put a risk. As a team, the Sense Net could reconnoiter a set of buildings faster, more reliably, and more comprehensibly than an individual mobot. The team, for example, could dynamically form subteams to perform task that cannot be done by individual robots, such as measuring the range to a distant object by forming a long baseline stereo sensor form a pari of mobots. In addition, the team could automatically reconfigure itself to handle contingencies such as disabled mobots. This paper is a report of our current progress in developing the Sense Net, after the first year of a two-year project. In our approach, each mobot has sufficient autonomy to perform several tasks, such as mapping unknown areas, navigating to specific positions, and detecting, tracking, characterizing, and classifying human and vehicular activity. We detail how some of these tasks are accomplished, and how the mobot group is tasked.

Results on the spatial resolution of repetitive transcranial magnetic stimulation for cortical language mapping during object naming in healthy subjects.

PubMed

Sollmann, Nico; Hauck, Theresa; Tussis, Lorena; Ille, Sebastian; Maurer, Stefanie; Boeckh-Behrens, Tobias; Ringel, Florian; Meyer, Bernhard; Krieg, Sandro M

2016-10-24

The spatial resolution of repetitive navigated transcranial magnetic stimulation (rTMS) for language mapping is largely unknown. Thus, to determine a minimum spatial resolution of rTMS for language mapping, we evaluated the mapping sessions derived from 19 healthy volunteers for cortical hotspots of no-response errors. Then, the distances between hotspots (stimulation points with a high error rate) and adjacent mapping points (stimulation points with low error rates) were evaluated. Mean distance values of 13.8 ± 6.4 mm (from hotspots to ventral points, range 0.7-30.7 mm), 10.8 ± 4.8 mm (from hotspots to dorsal points, range 2.0-26.5 mm), 16.6 ± 4.8 mm (from hotspots to apical points, range 0.9-27.5 mm), and 13.8 ± 4.3 mm (from hotspots to caudal points, range 2.0-24.2 mm) were measured. According to the results, the minimum spatial resolution of rTMS should principally allow for the identification of a particular gyrus, and according to the literature, it is in good accordance with the spatial resolution of direct cortical stimulation (DCS). Since measurement was performed between hotspots and adjacent mapping points and not on a finer-grained basis, we only refer to a minimum spatial resolution. Furthermore, refinement of our results within the scope of a prospective study combining rTMS and DCS for resolution measurement during language mapping should be the next step.

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

PubMed Central

Roth Flach, Rachel J.; Skoura, Athanasia; Matevossian, Anouch; Danai, Laura V.; Zheng, Wei; Cortes, Christian; Bhattacharya, Samit K.; Aouadi, Myriam; Hagan, Nana; Yawe, Joseph C.; Vangala, Pranitha; Menendez, Lorena Garcia; Cooper, Marcus P.; Fitzgibbons, Timothy P.; Buckbinder, Leonard; Czech, Michael P.

2015-01-01

Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, is abundantly expressed in ECs and in atherosclerotic plaques from mice and humans. On the basis of endothelial-specific MAP4K4 gene silencing and gene ablation experiments in Apoe−/− mice, we show that MAP4K4 in ECs markedly promotes Western diet-induced aortic macrophage accumulation and atherosclerotic plaque development. Treatment of Apoe−/− and Ldlr−/− mice with a selective small-molecule MAP4K4 inhibitor also markedly reduces atherosclerotic lesion area. MAP4K4 silencing in cultured ECs attenuates cell surface adhesion molecule expression while reducing nuclear localization and activity of NFκB, which is critical for promoting EC activation and atherosclerosis. Taken together, these results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis. PMID:26688060

Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa

PubMed Central

BROOKER, S.; KABATEREINE, N. B.; GYAPONG, J. O.; STOTHARD, J. R.; UTZINGER, J.

2009-01-01

SUMMARY There is growing interest and commitment to the control of schistosomiasis and other so-called neglected tropical diseases (NTDs). Resources for control are inevitably limited, necessitating assessment methods that can rapidly and accurately identify and map high-risk communities so that interventions can be targeted in a spatially-explicit and cost-effective manner. Here, we review progress made with (i) mapping schistosomiasis across Africa using available epidemiological data and more recently, climate-based risk prediction; (ii) the development and use of morbidity questionnaires for rapid identification of high-risk communities of urinary schistosomiasis; and (iii) innovative sampling-based approaches for intestinal schistosomiasis, using the lot quality assurance sampling technique. Experiences are also presented for the rapid mapping of other NTDs, including onchocerciasis, loiasis and lymphatic filariasis. Future directions for an integrated rapid mapping approach targeting multiple NTDs simultaneously are outlined, including potential challenges in developing an integrated survey tool. The lessons from the mapping of human helminth infections may also be relevant for the rapid mapping of malaria as its control efforts are intensified. PMID:19450373

Modeling a color-rendering operator for high dynamic range images using a cone-response function

NASA Astrophysics Data System (ADS)

Choi, Ho-Hyoung; Kim, Gi-Seok; Yun, Byoung-Ju

2015-09-01

Tone-mapping operators are the typical algorithms designed to produce visibility and the overall impression of brightness, contrast, and color of high dynamic range (HDR) images on low dynamic range (LDR) display devices. Although several new tone-mapping operators have been proposed in recent years, the results of these operators have not matched those of the psychophysical experiments based on the human visual system. A color-rendering model that is a combination of tone-mapping and cone-response functions using an XYZ tristimulus color space is presented. In the proposed method, the tone-mapping operator produces visibility and the overall impression of brightness, contrast, and color in HDR images when mapped onto relatively LDR devices. The tone-mapping resultant image is obtained using chromatic and achromatic colors to avoid well-known color distortions shown in the conventional methods. The resulting image is then processed with a cone-response function wherein emphasis is placed on human visual perception (HVP). The proposed method covers the mismatch between the actual scene and the rendered image based on HVP. The experimental results show that the proposed method yields an improved color-rendering performance compared to conventional methods.

Perception for rugged terrain

NASA Technical Reports Server (NTRS)

Kweon, In SO; Hebert, Martial; Kanade, Takeo

1989-01-01

A three-dimensional perception system for building a geometrical description of rugged terrain environments from range image data is presented with reference to the exploration of the rugged terrain of Mars. An intermediate representation consisting of an elevation map that includes an explicit representation of uncertainty and labeling of the occluded regions is proposed. The locus method used to convert range image to an elevation map is introduced, along with an uncertainty model based on this algorithm. Both the elevation map and the locus method are the basis of a terrain matching algorithm which does not assume any correspondences between range images. The two-stage algorithm consists of a feature-based matching algorithm to compute an initial transform and an iconic terrain matching algorithm to merge multiple range images into a uniform representation. Terrain modeling results on real range images of rugged terrain are presented. The algorithms considered are a fundamental part of the perception system for the Ambler, a legged locomotor.

High school chemistry students' learning of the elements, structure, and periodicity of the periodic table: Contributions of inquiry-based activities and exemplary graphics

NASA Astrophysics Data System (ADS)

Roddy, Knight Phares, Jr.

The main research question of this study was: How do selected high school chemistry students' understandings of the elements, structure, and periodicity of the Periodic Table change as they participate in a unit study consisting of inquiry-based activities emphasizing construction of innovative science graphics? The research question was answered using a multiple case study/mixed model design which employed elements of both qualitative and quantitative methodologies during data collection and analyses. The unit study was conducted over a six-week period with 11th -grade students enrolled in a chemistry class. A purposive sample of six students from the class was selected to participate in interviews and concept map coconstruction (Wandersee & Abrams, 1993) periodically across the study. The progress of the selected students of the case study was compared to the progress of the class as a whole. The students of the case study were also compared to a group of high school chemistry students at a comparative school. The results show that the students from both schools left traditional instruction on the periodic table (lecture and textbook activities) with a very limited understanding of the topic. It also revealed that the inquiry-based, visual approach of the unit study helped students make significant conceptual progress in their understanding of the periodic table. The pictorial periodic table (which features photographs of the elements), used in conjunction with the graphic technique of data mapping, enhanced students understanding of the patterns of the physical properties of the elements on the periodic table. The graphic technique of compound mapping helped students learn reactivity patterns between types and groups of elements on the periodic table. The recreation of the periodic table with element cards created from the pictorial periodic table helped students progress in their understanding of periodicity and its key concepts. The Periodic Table Literacy Rubric (PTLR) proved to be a valuable tool for assessing students' conceptual progress, and helped to identify a critical juncture in the learning of periodicity. In addition, the PTLR rubric's historical-conceptual design demonstrates how the history of science can be used to inform today's science teaching.

Mapping the Early Intervention System in Ontario, Canada

ERIC Educational Resources Information Center

Underwood, Kathryn

2012-01-01

This study documents the wide range of early intervention services across the province of Ontario. The services are mapped across the province showing geographic information as well as the scope of services (clinical, family-based, resource support, etc.), the range of early intervention professionals, sources of funding and the populations served…

Abstracts of the Annual Meeting of Planetary Geologic Mappers, San Antonio, TX, 2009

NASA Technical Reports Server (NTRS)

Bleamaster, Leslie F., III (Editor); Tanaka, Kenneth L.; Kelley, Michael S.

2009-01-01

Topics covered include: Geologic Mapping of the Beta-Atla-Themis (BAT) Region of Venus: A Progress Report; Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for Tectonic and Volcanic History of the North Polar Region of Venus; Preliminary Geological Map of the Fortuna Tessera (V-2) Quadrangle, Venus; Geological Map of the Fredegonde (V-57) Quadrangle, Venus; Geological Mapping of the Lada Terra (V-56) Quadrangle, Venus; Geologic Mapping of V-19; Lunar Geologic Mapping: A Preliminary Map of a Portion of the LQ-10 ("Marius") Quadrangle; Geologic Mapping of the Lunar South Pole, Quadrangle LQ-30: Volcanic History and Stratigraphy of Schr dinger Basin; Geologic Mapping along the Arabia Terra Dichotomy Boundary: Mawrth Vallis and Nili Fossae, Mars; Geologic Mapping Investigations of the Northwest Rim of Hellas Basin, Mars; Geologic Mapping of the Meridiani Region of Mars; Geology of a Portion of the Martian Highlands: MTMs -20002, -20007, -25002 and -25007; Geologic Mapping of Holden Crater and the Uzboi-Ladon-Morava Outflow System; Mapping Tyrrhena Patera and Hesperia Planum, Mars; Geologic Mapping of Athabaca Valles; Geologic Mapping of MTM -30247, -35247 and -40247 Quadrangles, Reull Vallis Region, Mars Topography of the Martian Impact Crater Tooting; Mars Structural and Stratigraphic Mapping along the Coprates Rise; Geology of Libya Montes and the Interbasin Plains of Northern Tyrrhena Terra, Mars: Project Introduction and First Year Work Plan; Geology of the Southern Utopia Planitia Highland-Lowland Boundary Plain: Second Year Results and Third Year Plan; Mars Global Geologic Mapping: About Half Way Done; New Geologic Map of the Scandia Region of Mars; Geologic Mapping of the Medusae Fossae Formation on Mars and the Northern Lowland Plains of Venus; Volcanism on Io: Insights from Global Geologic Mapping; and Planetary Geologic Mapping Handbook - 2009.

CELL5M: A geospatial database of agricultural indicators for Africa South of the Sahara.

PubMed

Koo, Jawoo; Cox, Cindy M; Bacou, Melanie; Azzarri, Carlo; Guo, Zhe; Wood-Sichra, Ulrike; Gong, Queenie; You, Liangzhi

2016-01-01

Recent progress in large-scale georeferenced data collection is widening opportunities for combining multi-disciplinary datasets from biophysical to socioeconomic domains, advancing our analytical and modeling capacity. Granular spatial datasets provide critical information necessary for decision makers to identify target areas, assess baseline conditions, prioritize investment options, set goals and targets and monitor impacts. However, key challenges in reconciling data across themes, scales and borders restrict our capacity to produce global and regional maps and time series. This paper provides overview, structure and coverage of CELL5M-an open-access database of geospatial indicators at 5 arc-minute grid resolution-and introduces a range of analytical applications and case-uses. CELL5M covers a wide set of agriculture-relevant domains for all countries in Africa South of the Sahara and supports our understanding of multi-dimensional spatial variability inherent in farming landscapes throughout the region.

iVAX: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines.

PubMed

Moise, Leonard; Gutierrez, Andres; Kibria, Farzana; Martin, Rebecca; Tassone, Ryan; Liu, Rui; Terry, Frances; Martin, Bill; De Groot, Anne S

2015-01-01

Computational vaccine design, also known as computational vaccinology, encompasses epitope mapping, antigen selection and immunogen design using computational tools. The iVAX toolkit is an integrated set of tools that has been in development since 1998 by De Groot and Martin. It comprises a suite of immunoinformatics algorithms for triaging candidate antigens, selecting immunogenic and conserved T cell epitopes, eliminating regulatory T cell epitopes, and optimizing antigens for immunogenicity and protection against disease. iVAX has been applied to vaccine development programs for emerging infectious diseases, cancer antigens and biodefense targets. Several iVAX vaccine design projects have had success in pre-clinical studies in animal models and are progressing toward clinical studies. The toolkit now incorporates a range of immunoinformatics tools for infectious disease and cancer immunotherapy vaccine design. This article will provide a guide to the iVAX approach to computational vaccinology.

Serial removal of caries lesions from tooth occlusal surfaces using near-IR image-guided IR laser ablation

NASA Astrophysics Data System (ADS)

Chan, Kenneth H.; Tom, Henry; Darling, Cynthia L.; Fried, Daniel

2015-02-01

Previous studies have established that caries lesions can be imaged with high contrast without the interference of stains at near-IR wavelengths greater than 1300-nm. It has been demonstrated that computer controlled laser scanning systems utilizing IR lasers operating at high pulse repetition rates can be used for serial imaging and selective removal of caries lesions. In this study, we report our progress towards the development of algorithms for generating rasterized ablation maps from near-IR reflectance images for the removal of natural lesions from tooth occlusal surfaces. An InGaAs camera and a filtered tungsten-halogen lamp producing near-IR light in the range of 1500-1700-nm were used to collect crosspolarization reflectance images of tooth occlusal surfaces. A CO2 laser operating at a wavelength of 9.3- μm with a pulse duration of 10-15-μs was used for image-guided ablation.

Transmission Parameters of the 2001 Foot and Mouth Epidemic in Great Britain

PubMed Central

Chis Ster, Irina; Ferguson, Neil M.

2007-01-01

Despite intensive ongoing research, key aspects of the spatial-temporal evolution of the 2001 foot and mouth disease (FMD) epidemic in Great Britain (GB) remain unexplained. Here we develop a Markov Chain Monte Carlo (MCMC) method for estimating epidemiological parameters of the 2001 outbreak for a range of simple transmission models. We make the simplifying assumption that infectious farms were completely observed in 2001, equivalent to assuming that farms that were proactively culled but not diagnosed with FMD were not infectious, even if some were infected. We estimate how transmission parameters varied through time, highlighting the impact of the control measures on the progression of the epidemic. We demonstrate statistically significant evidence for assortative contact patterns between animals of the same species. Predictive risk maps of the transmission potential in different geographic areas of GB are presented for the fitted models. PMID:17551582

Comparative studies on cervical and colonic malignancies using FTIR microspectroscopy

NASA Astrophysics Data System (ADS)

Mordechai, Shaul; Mark, Shlomo; Podshyvalov, A.; Kantarovich, Keren; Bernshtain, Y.; Salman, Ahmad; Erukhimovitch, Vitaly; Guterman, Hugo; Goldstein, Jed; Argov, Shmuel; Jagannathan, R.

2003-07-01

IR spectroscopy provides a new diagnostic tool due to its sensitivity to molecular composition and structure in cells, which accompany transformation from healthy to diseased state. The IR spectrum of a sample is, therefore, a biochemical fingerprint. It has been found that the most significant changes occur in the mid-IR spectral range 3-25 mm. Encouraging results have been reported in the literature on various types of cancers, such as human breast, lung, colon, cervical, and leukemia using FT-IR microspectroscopy. Much progress has also been made by several groups on IR spectral maps and IR imaging with good agreement between the data and the histopathological information. In an attempt to characterize healthy and diseased tissues, infrared microspectroscopy of cervical and colon human tissues was studied using an infrared microscopy. The comparative qualitative and quantitative changes detected using FTIR microspectroscopy are discussed.

An improved artifact removal in exposure fusion with local linear constraints

NASA Astrophysics Data System (ADS)

Zhang, Hai; Yu, Mali

2018-04-01

In exposure fusion, it is challenging to remove artifacts because of camera motion and moving objects in the scene. An improved artifact removal method is proposed in this paper, which performs local linear adjustment in artifact removal progress. After determining a reference image, we first perform high-dynamic-range (HDR) deghosting to generate an intermediate image stack from the input image stack. Then, a linear Intensity Mapping Function (IMF) in each window is extracted based on the intensities of intermediate image and reference image, the intensity mean and variance of reference image. Finally, with the extracted local linear constraints, we reconstruct a target image stack, which can be directly used for fusing a single HDR-like image. Some experiments have been implemented and experimental results demonstrate that the proposed method is robust and effective in removing artifacts especially in the saturated regions of the reference image.

Perspective: Advanced particle imaging

DOE PAGES

Chandler, David W.; Houston, Paul L.; Parker, David H.

2017-05-26

This study discuss, the first ion imaging experiment demonstrating the capability of collecting an image of the photofragments from a unimolecular dissociation event and analyzing that image to obtain the three-dimensional velocity distribution of the fragments, the efficacy and breadth of application of the ion imaging technique have continued to improve and grow. With the addition of velocity mapping, ion/electron centroiding, and slice imaging techniques, the versatility and velocity resolution have been unmatched. Recent improvements in molecular beam, laser, sensor, and computer technology are allowing even more advanced particle imaging experiments, and eventually we can expect multi-mass imaging with co-variancemore » and full coincidence capability on a single shot basis with repetition rates in the kilohertz range. This progress should further enable “complete” experiments—the holy grail of molecular dynamics—where all quantum numbers of reactants and products of a bimolecular scattering event are fully determined and even under our control.« less

Maps of the Magellanic clouds from combined South Pole Telescope and Planck data

DOE PAGES

Crawford, T. M.; Chown, R.; Holder, G. P.; ...

2016-12-09

Here, we present maps of the Large and Small Magellanic Clouds from combined South Pole Telescope (SPT) and Planck data. Both instruments are designed to make measurements of the cosmic microwave background but are sensitive to any source of millimeter-wave (mm-wave) emission. The Planck satellite observes in nine mm-wave bands, while the SPT data used in this work were taken with the three-band SPT-SZ camera. The SPT-SZ bands correspond closely to three of the nine Planck bands, namely those centered at 1.4, 2.1, and 3.0 mm. The angular resolution of the Planck data in these bands ranges from 5 tomore » 10 arcmin, while the SPT resolution in these bands ranges from 1.0 to 1.7 arcmin. The combined maps take advantage of the high resolution of the SPT data and the long-timescale stability of the space-based Planck observations to deliver high signal-to-noise and robust brightness measurements on scales from the size of the maps down to ~1 arcmin. In each of the three bands, we first calibrate and color-correct the SPT data to match the Planck data, then we use noise estimates from each instrument and knowledge of each instrument's beam, or point-spread function, to make the inverse-variance-weighted combination of the two instruments' data as a function of angular scale. Furthermore, we create maps assuming a range of underlying emission spectra (for the color correction) and at a range of final resolutions. We perform several consistency tests on the combined maps and estimate the expected noise in measurements of features in the maps. Finally, we compare the maps of the Large Magellanic Cloud (LMC) from this work to maps from the Herschel HERITAGE survey, finding general consistency between the datasets. Furthermore, the broad wavelength coverage provides evidence of different emission mechanisms at work in different environments in the LMC.« less

Estimating and mapping the population at risk of sleeping sickness.

PubMed

Simarro, Pere P; Cecchi, Giuliano; Franco, José R; Paone, Massimo; Diarra, Abdoulaye; Ruiz-Postigo, José Antonio; Fèvre, Eric M; Mattioli, Raffaele C; Jannin, Jean G

2012-01-01

Human African trypanosomiasis (HAT), also known as sleeping sickness, persists as a public health problem in several sub-Saharan countries. Evidence-based, spatially explicit estimates of population at risk are needed to inform planning and implementation of field interventions, monitor disease trends, raise awareness and support advocacy. Comprehensive, geo-referenced epidemiological records from HAT-affected countries were combined with human population layers to map five categories of risk, ranging from "very high" to "very low," and to estimate the corresponding at-risk population. Approximately 70 million people distributed over a surface of 1.55 million km(2) are estimated to be at different levels of risk of contracting HAT. Trypanosoma brucei gambiense accounts for 82.2% of the population at risk, the remaining 17.8% being at risk of infection from T. b. rhodesiense. Twenty-one million people live in areas classified as moderate to very high risk, where more than 1 HAT case per 10,000 inhabitants per annum is reported. Updated estimates of the population at risk of sleeping sickness were made, based on quantitative information on the reported cases and the geographic distribution of human population. Due to substantial methodological differences, it is not possible to make direct comparisons with previous figures for at-risk population. By contrast, it will be possible to explore trends in the future. The presented maps of different HAT risk levels will help to develop site-specific strategies for control and surveillance, and to monitor progress achieved by ongoing efforts aimed at the elimination of sleeping sickness.

A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy.

PubMed

Wang, Jiahui; Fan, Zheng; Vandenborne, Krista; Walter, Glenn; Shiloh-Malawsky, Yael; An, Hongyu; Kornegay, Joe N; Styner, Martin A

2013-09-01

Golden retriever muscular dystrophy (GRMD) is a widely used canine model of Duchenne muscular dystrophy (DMD). Recent studies have shown that magnetic resonance imaging (MRI) can be used to non-invasively detect consistent changes in both DMD and GRMD. In this paper, we propose a semiautomated system to quantify MRI biomarkers of GRMD. Our system was applied to a database of 45 MRI scans from 8 normal and 10 GRMD dogs in a longitudinal natural history study. We first segmented six proximal pelvic limb muscles using a semiautomated full muscle segmentation method. We then performed preprocessing, including intensity inhomogeneity correction, spatial registration of different image sequences, intensity calibration of T2-weighted and T2-weighted fat-suppressed images, and calculation of MRI biomarker maps. Finally, for each of the segmented muscles, we automatically measured MRI biomarkers of muscle volume, intensity statistics over MRI biomarker maps, and statistical image texture features. The muscle volume and the mean intensities in T2 value, fat, and water maps showed group differences between normal and GRMD dogs. For the statistical texture biomarkers, both the histogram and run-length matrix features showed obvious group differences between normal and GRMD dogs. The full muscle segmentation showed significantly less error and variability in the proposed biomarkers when compared to the standard, limited muscle range segmentation. The experimental results demonstrated that this quantification tool could reliably quantify MRI biomarkers in GRMD dogs, suggesting that it would also be useful for quantifying disease progression and measuring therapeutic effect in DMD patients.

Experimental and theoretical studies of the colloidal stability of nanoparticles-a general interpretation based on stability maps.

PubMed

Segets, Doris; Marczak, Renata; Schäfer, Stefan; Paula, Carolin; Gnichwitz, Jan-Frederik; Hirsch, Andreas; Peukert, Wolfgang

2011-06-28

The current work addresses the understanding of the stabilization of nanoparticles in suspension. Specifically, we study ZnO in ethanol for which the influence of particle size and reactant ratio as well as surface coverage on colloidal stability in dependence of the purification progress was investigated. The results revealed that the well-known ζ-potential determines not only the colloidal stability but also the surface coverage of acetate groups bound to the particle surface. The acetate groups act as molecular spacers between the nanoparticles and prevent agglomeration. Next to DLVO calculations based on the theory of Derjaguin, Landau, Verwey and Overbeek using a core-shell model we find that the stability is better understood in terms of dimensionless numbers which represent attractive forces as well as electrostatic repulsion, steric effects, transport properties, and particle concentration. Evaluating the colloidal stability in dependence of time by means of UV-vis absorption measurements a stability map for ZnO is derived. From this map it becomes clear that the dimensionless steric contribution to colloidal stability scales with a stability parameter including dimensionless repulsion and attraction as well as particle concentration and diffusivity of the particles according to a power law with an exponent of -0.5. Finally, we show that our approach is valid for other stabilizing molecules like cationic dendrons and is generally applicable for a wide range of other material systems within the limitations of vanishing van der Waals forces in refractive index matched situations, vanishing ζ-potential and systems without a stabilizing shell around the particle surface.

Geology of the central and northern parts of the Western Cascade Range in Oregon

USGS Publications Warehouse

Peck, Dallas L.; Griggs, Allan B.; Schlicker, Herbert G.; Wells, Francis G.; Dole, Hollis M.

1964-01-01

This report pt·esents a description of the stratigraphy, structure, and petrology of the volcanic rocks of the central and northern parts of the Western Cascade Range of Oregon. The study is a part of a long-range cooperative program between the U.S. Geological Survey and the Oregon State Department of Geology and Mineral Industries to prepare a geologic map of Oregon. The map area, about 7,500 square miles, lies in the densely forested western slope of the Cascade Range. It is bounded approximately by lat 43° N. and lat 45°30' N. on the south and north, the crest of the range on the east, and long 123° W. and the edge of the Willamette Valley on the west. The geology, which was mapped by reconnaissance methods, is chiefly based on examination of rock exposures along roads. The Cascade Range in Oregon comprises two physiographic divisions: the Western Cascade Range, which includes a wide, deeply dissected belt of volcanic formations making up the western slope of the range, and the High Cascade Range, which includes chiefly younger cones and lava flows forming the nearly undissected crest of the range. The volcanic rocks of the Western Cascade Range are deformed and partially altered flows and pyroclastic rocks that range in age from late Eocene t·o lute Miocene, as determined chiefly from fossil plants from more than 50 localities. These volcanic rocks overlie or interfinger westward with marine sedimentary rocks, and in the southwestern part of the map area they overlie pre-Tertiary plutonic and metamorphic rocks of the Klamath Mountains.

Color Map of Ceres Elliptical Projection

NASA Image and Video Library

2016-03-22

This global map elliptical map from NASA Dawn spacecraft shows the surface of Ceres in enhanced color, encompassing infrared wavelengths beyond human visual range. Some areas near the poles are black where Dawn color imaging coverage is incomplete.

Enhanced digital mapping project : final report

DOT National Transportation Integrated Search

2004-11-19

The Enhanced Digital Map Project (EDMap) was a three-year effort launched in April 2001 to develop a range of digital map database enhancements that enable or improve the performance of driver assistance systems currently under development or conside...

Technical Data and Reports on Nitrogen Dioxide Measurements and SIP Status

EPA Pesticide Factsheets

EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

Technical Data and Reports on Carbon Monoxide Measurements and SIP Status

EPA Pesticide Factsheets

EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

(Mechanisms of inhibition of viral replication in plants)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-01-01

Progress is described concerning genetic mapping CMV movement genes for CMV coat protein in squash and ToMV gene in tomato. These gene products appear to be involved in resistance to squash and tomato mosaic viruses respectively.

Transportation asset management : organizational performance and risk review : final report.

DOT National Transportation Integrated Search

2012-11-15

The 2012 Federal reauthorization of surface transportation programs, Moving Ahead for Progress in the 21st : Century (MAP-21) formally introduced performance-based decision making for investments in surface : transportation programs. This report revi...

Mapping longitudinal stream connectivity in the North St. Vrain Creek watershed of Colorado

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wohl, Ellen; Rathburn, Sara; Chignell, Stephen

We use reach-scale stream gradient as an indicator of longitudinal connectivity for water, sediment, and organic matter in a mountainous watershed in Colorado. Stream reaches with the highest gradient tend to have narrow valley bottoms with limited storage space and attenuation of downstream fluxes, whereas stream reaches with progressively lower gradients have progressively more storage and greater attenuation. We compared the distribution of stream gradient to stream-reach connectivity rankings that incorporated multiple potential control variables, including lithology, upland vegetation, hydroclimatology, road crossings, and flow diversions. We then assessed connectivity rankings using different weighting schemes against stream gradient and against field-basedmore » understanding of relative connectivity within the watershed. Here, we conclude that stream gradient, which is simple to map using publicly available data and digital elevation models, is the most robust indicator of relative longitudinal connectivity within the river network.« less

The Evolving Landscape of Healthcare-Associated Infections: Recent Advances in Prevention and a Road Map for Research

PubMed Central

Safdar, Nasia; Anderson, Deverick J.; Braun, Barbara I.; Carling, Philip; Cohen, Stuart; Donskey, Curtis; Drees, Marci; Harris, Anthony; Henderson, David K.; Huang, Susan S.; Juthani-Mehta, Manisha; Lautenbach, Ebbing; Linkin, Darren R.; Meddings, Jennifer; Miller, Loren G.; Milstone, Aaron; Morgan, Daniel; Sengupta, Sharmila; Varman, Meera; Yokoe, Deborah; Zerr, Danielle M.

2014-01-01

This white paper identifies knowledge gaps and new challenges in healthcare epidemiology research, assesses the progress made toward addressing research priorities, provides the Society for Healthcare Epidemiology of America (SHEA) Research Committee’s recommendations for high-priority research topics, and proposes a road map for making progress toward these goals. It updates the 2010 SHEA Research Committee document, “Charting the Course for the Future of Science in Healthcare Epidemiology: Results of a Survey of the Membership of SHEA,” which called for a national approach to healthcare-associated infections (HAIs) and a prioritized research agenda. This paper highlights recent studies that have advanced our understanding of HAIs, the establishment of the SHEA Research Network as a collaborative infrastructure to address research questions, prevention initiatives at state and national levels, changes in reporting and payment requirements, and new patterns in antimicrobial resistance. PMID:24709716

Mapping longitudinal stream connectivity in the North St. Vrain Creek watershed of Colorado

DOE PAGES

Wohl, Ellen; Rathburn, Sara; Chignell, Stephen; ...

2016-05-06

We use reach-scale stream gradient as an indicator of longitudinal connectivity for water, sediment, and organic matter in a mountainous watershed in Colorado. Stream reaches with the highest gradient tend to have narrow valley bottoms with limited storage space and attenuation of downstream fluxes, whereas stream reaches with progressively lower gradients have progressively more storage and greater attenuation. We compared the distribution of stream gradient to stream-reach connectivity rankings that incorporated multiple potential control variables, including lithology, upland vegetation, hydroclimatology, road crossings, and flow diversions. We then assessed connectivity rankings using different weighting schemes against stream gradient and against field-basedmore » understanding of relative connectivity within the watershed. Here, we conclude that stream gradient, which is simple to map using publicly available data and digital elevation models, is the most robust indicator of relative longitudinal connectivity within the river network.« less

Recent progress on the genetics and molecular breeding of brown planthopper resistance in rice.

PubMed

Hu, Jie; Xiao, Cong; He, Yuqing

2016-12-01

Brown planthopper (BPH) is the most devastating pest of rice. Host-plant resistance is the most desirable and economic strategy in the management of BPH. To date, 29 major BPH resistance genes have been identified from indica cultivars and wild rice species, and more than ten genes have been fine mapped to chromosome regions of less than 200 kb. Four genes (Bph14, Bph26, Bph17 and bph29) have been cloned. The increasing number of fine-mapped and cloned genes provide a solid foundation for development of functional markers for use in breeding. Several BPH resistant introgression lines (ILs), near-isogenic lines (NILs) and pyramided lines (PLs) carrying single or multiple resistance genes were developed by marker assisted backcross breeding (MABC). Here we review recent progress on the genetics and molecular breeding of BPH resistance in rice. Prospect for developing cultivars with durable, broad-spectrum BPH resistance are discussed.

Ranges of North American breeding birds: visualizing long-term population changes in North American breeding birds

USGS Publications Warehouse

Price, Jeff

1995-01-01

These maps show changes in the distribution and abundance patterns of some North American birds for the last 20 years. For each species there are four maps, each representing the average distribution and abundance pattern over the five-year periods 1970-1974, 1975-1979, 1980-1984, and 1985-1989. The maps are based on data collected by the USFWS/CWS Breeding Bird Survey (BBS). Only BBS routes that were run at least once during each of the five-year periods were used (about 1300 routes). The maps were created in the software package Surfer using a kriging technique to interpolate mean relative abundances for areas where no routes were run. On each map, a portion of northeast Canada was blanked out because there were not enough routes to allow for adequate interpolation. All of the maps in this presentation use the same color scale (shown below). The minimum value mapped was 0.5 birds per route, which represents the edge of the species range.

SfiI genomic cleavage map of Escherichia coli K-12 strain MG1655.

PubMed Central

Perkins, J D; Heath, J D; Sharma, B R; Weinstock, G M

1992-01-01

An SfiI restriction map of Escherichia coli K-12 strain MG1655 is presented. The map contains thirty-one cleavage sites separating fragments ranging in size from 407 kb to 3.7 kb. Several techniques were used in the construction of this map, including CHEF pulsed field gel electrophoresis; physical analysis of a set of twenty-six auxotrophic transposon insertions; correlation with the restriction map of Kohara and coworkers using the commercially available E. coli Gene Mapping Membranes; analysis of publicly available sequence information; and correlation of the above data with the combined genetic and physical map developed by Rudd, et al. The combination of these techniques has yielded a map in which all but one site can be localized within a range of +/- 2 kb, and over half the sites can be localized precisely by sequence data. Two sites present in the EcoSeq5 sequence database are not cleaved in MG1655 and four sites are noted to be sensitive to methylation by the dcm methylase. This map, combined with the NotI physical map of MG1655, can aid in the rapid, precise mapping of several different types of genetic alterations, including transposon mediated mutations and other insertions, inversions, deletions and duplications. Images PMID:1312707

Geologic Map of the Carlton Quadrangle, Yamhill County, Oregon

USGS Publications Warehouse

Wheeler, Karen L.; Wells, Ray E.; Minervini, Joseph M.; Block, Jessica L.

2009-01-01

The Carlton, Oregon, 7.5-minute quadrangle is located in northwestern Oregon, about 35 miles (57 km) southwest of Portland. It encompasses the towns of Yamhill and Carlton in the northwestern Willamette Valley and extends into the eastern flank of the Oregon Coast Range. The Carlton quadrangle is one of several dozen quadrangles being mapped by the U.S. Geological Survey (USGS) and the Oregon Department of Geology and Mineral Industries (DOGAMI) to provide a framework for earthquake- hazard assessments in the greater Portland, Oregon, metropolitan area. The focus of USGS mapping is on the structural setting of the northern Willamette Valley and its relation to the Coast Range uplift. Mapping was done in collaboration with soil scientists from the National Resource Conservation Service, and the distribution of geologic units is refined over earlier regional mapping (Schlicker and Deacon, 1967). Geologic mapping was done on 7.5-minute topographic base maps and digitized in ArcGIS to produce ArcGIS geodatabases and PDFs of the map and text. The geologic contacts are based on numerous observations and samples collected in 2002 and 2003, National Resource Conservation Service soils maps, and interpretations of 7.5-minute topography. The map was completed before new, high-resolution laser terrain mapping was flown for parts of the northern Willamette Valley in 2008.

New segmentation-based tone mapping algorithm for high dynamic range image

NASA Astrophysics Data System (ADS)

Duan, Weiwei; Guo, Huinan; Zhou, Zuofeng; Huang, Huimin; Cao, Jianzhong

2017-07-01

The traditional tone mapping algorithm for the display of high dynamic range (HDR) image has the drawback of losing the impression of brightness, contrast and color information. To overcome this phenomenon, we propose a new tone mapping algorithm based on dividing the image into different exposure regions in this paper. Firstly, the over-exposure region is determined using the Local Binary Pattern information of HDR image. Then, based on the peak and average gray of the histogram, the under-exposure and normal-exposure region of HDR image are selected separately. Finally, the different exposure regions are mapped by differentiated tone mapping methods to get the final result. The experiment results show that the proposed algorithm achieve the better performance both in visual quality and objective contrast criterion than other algorithms.

Evaluation of land use mapping from ERTS in the shore zone of CARETS

NASA Technical Reports Server (NTRS)

Dolan, R.; Vincent, L.

1973-01-01

Imagery of the Atlantic shoreline zone of the Central Atlantic Regional Ecological Test Site (CARETS) was evaluated for classifying land use and land cover, employing the USGS Geographic Application Program's land use classification system. ERTS data can provide a basis for land cover and land use mapping within the shoreline zone, however because of the dynamic nature of this environment, two additional terms are considered: vulnerability of classes to storms and progressive erosion, and sensitivity of the classes to man's activities.

Current progress in multiple-image blind demixing algorithms

NASA Astrophysics Data System (ADS)

Szu, Harold H.

2000-06-01

Imagery edges occur naturally in human visual systems as a consequence of redundancy reduction towards `sparse and orthogonality feature maps,' which have been recently derived from the maximum entropy information-theoretical first principle of artificial neural networks. After a brief match review of such an Independent Component Analysis or Blind Source Separation of edge maps, we explore the de- mixing condition for more than two imagery objects recognizable by an intelligent pair of cameras with memory in a time-multiplex fashion.

Opportunity Traverse Map, Sol 383

NASA Technical Reports Server (NTRS)

2005-01-01

[figure removed for brevity, see original site] Figure 1

NASA's Mars Exploration Rover Opportunity drove a total of 2,801 meters (1.74 miles) between its landing in January 2004 and its 383rd martian day, or sol (Feb. 20, 2005). This map on an image taken by the Mars Orbiter Camera on NASA's Mars Global Surveyor shows the course the rover drove during that period. Recently, Opportunity has been making rapid progress from 'Endurance Crater' toward exploration targets farther south.

Deterrence Adrift Mapping Conflict and Escalation in South Asia

DTIC Science & Technology

2016-06-21

Response, published in December 2011. ✵ ✵ ✵ ✵ ✵ Ryan W. French is a researcher and operations specialist for the Naval War College’s Strategic Re- search...relation- ship, India ordered Pakistan International Airlines to shutter its offices in New Delhi.4 As 2015 progressed, the acrimony showed little sign of...extant literature by map- ping the military operational imperatives New Delhi and Islamabad might face in a Cold Start contingency and by analyzing the

Progress toward a circulation atlas for application to coastal water siting problems

NASA Technical Reports Server (NTRS)

Munday, J. C., Jr.; Gordon, H. H.

1978-01-01

Circulation data needed to resolve coastal siting problems are assembled from historical hydrographic and remote sensing studies in the form of a Circulation Atlas. Empirical data are used instead of numerical model simulations to achieve fine resolution and include fronts and convergence zones. Eulerian and Langrangian data are collected, transformed, and combined into trajectory maps and current vector maps as a function of tidal phase and wind vector. Initial Atlas development is centered on the Elizabeth River, Hampton Roads, Virgina.

Database for the geologic map of the Bend 30- x 60-minute quadrangle, central Oregon

USGS Publications Warehouse

Koch, Richard D.; Ramsey, David W.; Sherrod, David R.; Taylor, Edward M.; Ferns, Mark L.; Scott, William E.; Conrey, Richard M.; Smith, Gary A.

2010-01-01

The Bend 30- x 60-minute quadrangle has been the locus of volcanism, faulting, and sedimentation for the past 35 million years. It encompasses parts of the Cascade Range and Blue Mountain geomorphic provinces, stretching from snowclad Quaternary stratovolcanoes on the west to bare rocky hills and sparsely forested juniper plains on the east. The Deschutes River and its large tributaries, the Metolius and Crooked Rivers, drain the area. Topographic relief ranges from 3,157 m (10,358 ft) at the top of South Sister to 590 m (1,940 ft) at the floor of the Deschutes and Crooked Rivers where they exit the area at the north-central edge of the map area. The map encompasses a part of rapidly growing Deschutes County. The city of Bend, which has over 70,000 people living in its urban growth boundary, lies at the south-central edge of the map. Redmond, Sisters, and a few smaller villages lie scattered along the major transportation routes of U.S. Highways 97 and 20. This geologic map depicts the geologic setting as a basis for structural and stratigraphic analysis of the Deschutes basin, a major hydrologic discharge area on the east flank of the Cascade Range. The map also provides a framework for studying potentially active faults of the Sisters fault zone, which trends northwest across the map area from Bend to beyond Sisters. This digital release contains all of the information used to produce the geologic map published as U.S. Geological Survey Geologic Investigations Series I-2683 (Sherrod and others, 2004). The main component of this digital release is a geologic map database prepared using ArcInfo GIS. This release also contains files to view or print the geologic map and accompanying descriptive pamphlet from I-2683.

Establishment of a high-resolution 2-D reference map of human spermatozoal proteins from 12 fertile sperm-bank donors.

PubMed

Li, Ling-Wei; Fan, Li-Qing; Zhu, Wen-Bing; Nien, Hong-Chuan; Sun, Bo-Lan; Luo, Ke-Li; Liao, Ting-Ting; Tang, Le; Lu, Guang-Xiu

2007-05-01

To extend the analysis of the proteome of human spermatozoa and establish a 2-D gel electrophoresis (2-DE) reference map of human spermatozoal proteins in a pH range of 3.5-9.0. In order to reveal more protein spots, immobilized pH gradient strips (24 cm) of broad range of pH 3-10 and the narrower range of pH 6-9, as well as different overlapping narrow range pH immobilized pH gradient (IPG) strips, including 3.5-4.5, 4.0-5.0, 4.5-5.5, 5.0-6.0 and 5.5-6.7, were used. After 2-DE, several visually identical spots between the different pH range 2-D gel pairs were cut from the gels and confirmed by mass spectrometry and used as landmarks for computer analysis. The 2-D reference map with pH value from 3.5 to 9.0 was synthesized by using the ImageMaster analysis software. The overlapping spots were excluded, so that every spot was counted only once. A total of 3872 different protein spots were identified from the reference map, an approximately 3-fold increase compared to the broad range pH 3-10 IPG strip (1306 spots). The present 2-D pattern is a high resolution 2-D reference map for human fertile spermatozoal protein spots. A comprehensive knowledge of the protein composition of human spermatozoa is very meaningful in studying dysregulation of male fertility.

Sexual and reproductive health and rights of adolescent girls: Evidence from low- and middle-income countries

PubMed Central

Santhya, K.G.; Jejeebhoy, Shireen J.

2015-01-01

This paper reviews the evidence on sexual and reproductive health and rights (SRHR) of adolescent girls in low-income and middle-income countries (LMIC) in light of the policy and programme commitments made at the International Conference on Population and Development (ICPD), analyses progress since 1994, and maps challenges in and opportunities for protecting their health and human rights. Findings indicate that many countries have yet to make significant progress in delaying marriage and childbearing, reducing unintended childbearing, narrowing gender disparities that put girls at risk of poor SRH outcomes, expanding health awareness or enabling access to SRH services. While governments have reaffirmed many commitments, policy development and programme implementation fall far short of realising these commitments. Future success requires increased political will and engagement of young people in the formulation and implementation of policies and programmes, along with increased investments to deliver at scale comprehensive sexuality education, health services that are approachable and not judgemental, safe spaces programmes, especially for vulnerable girls, and programmes that engage families and communities. Stronger policy-making and programming also require expanding the evidence on adolescent health and rights in LMICs for both younger and older adolescents, boys and girls, and relating to a range of key health matters affecting adolescents. PMID:25554828

Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis.

PubMed

Psarakis, Michael; Greene, David; Moresi, Mark; Baker, Michael; Stubbs, Peter; Brodie, Matthew; Lord, Stephen; Hoang, Phu

2017-11-01

Gait impairment in people with Multiple Sclerosis results from neurological impairment, muscle weakness and reduced range of motion. Restrictions in passive ankle range of motion can result in abnormal heel-to-toe progression (weight transfer) and inefficient gait patterns in people with Multiple Sclerosis. The purpose of this study was to determine the associations between gait impairment, heel-to-toe progression and ankle range of motion in people with Multiple Sclerosis. Twelve participants with Multiple Sclerosis and twelve healthy age-matched participants were assessed. Spatiotemporal parameters of gait and individual footprint data were used to investigate group differences. A pressure sensitive walkway was used to divide each footprint into three phases (contact, mid-stance, propulsive) and calculate the heel-to-toe progression during the stance phase of gait. Compared to healthy controls, people with Multiple Sclerosis spent relatively less time in contact phase (7.8% vs 25.1%) and more time in the mid stance phase of gait (57.3% vs 33.7%). Inter-limb differences were observed in people with Multiple Sclerosis between the affected and non-affected sides for contact (7.8% vs 15.3%) and mid stance (57.3% and 47.1%) phases. Differences in heel-to-toe progression remained significant after adjusting for walking speed and were correlated with walking distance and ankle range of motion. Impaired heel-to-toe progression was related to poor ankle range of motion in people with Multiple Sclerosis. Heel-to-toe progression provided a sensitive measure for assessing gait impairments that were not detectable using standard spatiotemporal gait parameters. Copyright © 2017 Elsevier Ltd. All rights reserved.

Integrated geomorphologic and GIS analysis for the assessment of erosion zones and its relationship with hazardous zones in the Zacatecas and Guadalupe quadrangles, Mexico

NASA Astrophysics Data System (ADS)

Escalona-Alcázar, F. d. J.; Escobedo-Arellano, B.; Castillo-Félix, B.; Carrillo-Castillo, C.; García-Sandoval, P.; Gurrola-Menchaca, L. L.; Núñez-Peña, E. P.; Esparza-Martínez, A.; Bluhm-Gutiérrez, J.; Guijarro-Rodríguez, C. J.

2012-04-01

The morphology of the Zacatecas and Guadalupe quadrangles is composed to the West by a NNE-SSW fault bounded range and to the East a valley cut by minor hills. The most important and fast growing cities in the state are located in that range. However, in urban development plans variables such as the geology and geomorphologic processes, as well as the land cover characteristics, are poorly taken into consideration. Due to the landscape modification the erosion agents, mainly water, removes loose materials that are either natural or artificial. The effects on the buildings and roads are fractures, slope instability, and rock falling. In this study we present a model that considers the detailed geologic mapping, the geomorphology, land use, vegetation, and the digital slope model scale 1:50 000. The geomorphologic parameters considered were: relief energy, dissection density, general dissection density, and maximum dissection depth. The location and internal characteristics of mapped talus deposits were the basis to define the erosion criteria. High erosion zones are located in slopes over 20° where the talus deposits initiate due to the relative abundance of loose debris. Medium erosion areas are located in slopes over 10° that downslope has progressive accumulation of sediments. While the low erosion zones are located in slopes ranging from 5° to 20° with almost flat lying beds. These parameters were analyzed in ArcGIS together with the digital slope model, detailed geology mapping, the land use cover, and the soil information. The results where verified in the range where the city has been growing in recent years. The soils all over the range are lithosols which are only 10 to 15 cm thick; while the vegetation is composed mainly of bushes and nopals. Even though both, vegetation and soil are not modified, the erosion effects in them are very slow regardless of their location. The faults located in high erosion zones facilitate rock falling mainly during the rainy season; whereas in medium erosion zones it occurs if the road cuts or cliffs are steep. The rocks varying from loose to moderately consolidated, as well as the artificial fillings and talus deposits, are easily or difficultly eroded according with the erosion zones proposed in our model. The effects observed are fractured roads and house walls, removal of soil underneath the buildings, gullies formation, and slope instability. The model defines areas where the erosion effects can be related to the development of hazardous zones. This model gives criteria for land use planning and urban development.

Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypes.

PubMed

Rocca, Maria A; Valsasina, Paola; Damjanovic, Dusan; Horsfield, Mark A; Mesaros, Sarlota; Stosic-Opincal, Tatjana; Drulovic, Jelena; Filippi, Massimo

2013-01-01

To apply voxel-based methods to map the regional distribution of atrophy and T2 hyperintense lesions in the cervical cord of multiple sclerosis (MS) patients with different clinical phenotypes. Brain and cervical cord 3D T1-weighted and T2-weighted scans were acquired from 31 healthy controls (HC) and 77 MS patients (15 clinically isolated syndromes (CIS), 15 relapsing-remitting (RR), 19 benign (B), 15 primary progressive (PP) and 13 secondary progressive (SP) MS). Hyperintense cord lesions were outlined on T2-weighted scans. The T2- and 3D T1-weighted cord images were then analysed using an active surface method which created output images reformatted in planes perpendicular to the estimated cord centre line. These unfolded cervical cord images were co-registered into a common space; then smoothed binary cord masks and lesion masks underwent spatial statistic analysis (SPM8). No cord atrophy was found in CIS patients versus HC, while PPMS had significant cord atrophy. Clusters of cord atrophy were found in BMS versus RRMS, and in SPMS versus RRMS, BMS and PPMS patients, mainly involving the posterior and lateral cord segments. Cord lesion probability maps showed a significantly greater likelihood of abnormalities in RRMS, PPMS and SPMS than in CIS and BMS patients. The spatial distributions of cord atrophy and cord lesions were not correlated. In progressive MS, regional cord atrophy was correlated with clinical disability and impairment in the pyramidal system. Voxel-based assessment of cervical cord damage is feasible and may contribute to a better characterisation of the clinical heterogeneity of MS patients.

Putting Pluto's Geology on the Map

NASA Image and Video Library

2016-02-11

This geological map covers a portion of Pluto's surface that measures 1,290 miles (2,070 kilometers) from top to bottom, and includes the vast nitrogen-ice plain informally named Sputnik Planum and surrounding terrain. The map is overlain with colors that represent different geological terrains. Each terrain, or unit, is defined by its texture and morphology -- smooth, pitted, craggy, hummocky or ridged, for example. How well a unit can be defined depends on the resolution of the images that cover it. All of the terrain in this map has been imaged at a resolution of approximately 1,050 feet (320 meters) per pixel or better, meaning scientists can map units with relative confidence. The various blue and greenish units that fill the center of the map represent different textures seen across Sputnik Planum, from the cellular terrain in the center and north, to the smooth and pitted plains in the south. The black lines represent the troughs that mark the boundaries of cellular regions in the nitrogen ice. The purple unit represents the chaotic, blocky mountain ranges that line Sputnik's western border, and the pink unit represents the scattered, floating hills at its eastern edge. The possible cryovolcanic feature informally named Wright Mons is mapped in red in the southern corner of the map. The rugged highlands of the informally named Cthulhu Regio is mapped in dark brown along the western edge, and is pockmarked by many large impact craters, mapped in yellow. The base map for this geologic map is a mosaic of 12 images obtained by the Long Range Reconnaissance Imager (LORRI) at a resolution of 1,280 feet (about 390 meters) per pixel. The mosaic was obtained at a range of approximately 48,000 miles (77,300 kilometers) from Pluto, about an hour and 40 minutes before New Horizons' closest approach on July 14, 2015. http://photojournal.jpl.nasa.gov/catalog/PIA20465

Long-range restriction map of human chromosome 22q11-22q12 between the lambda immunoglobulin locus and the Ewing sarcoma breakpoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDermid, H.E.; Budarf, M.L.; Emanuel, B.S.

1993-11-01

A long-range restriction map of the region between the immunoglobulin lambda locus and the Ewing sarcoma breakpoint has been constructed using the rare-cutting enzymes NotI, NruI, AscI, and BsiWI. The map spans approximately 11,000 kb and represents about one-fifth of the long arm of chromosome 22. Thirty-nine markers, including seven NotI junction clones as well as numerous genes and anonymous sequences, were mapped to the region with a somatic cell hybrid panel. These probes were then used to produce the map. The seven NotI junction clones each identified a possible CpG island. The breakpoints of the RAJ5 hybrid and themore » Ewing sarcoma t(11;22) were also localized in the resulting map. This physical map will be useful in studying chromosomal rearrangements in the region, as well as providing the details to examine the fidelity of the YAC and cosmid contigs currently under construction. Comparisons of this physical map to genetic and radiation hybrid maps are discussed. 52 refs., 7 figs., 3 tabs.« less

Comparing the information content of coral reef geomorphological and biological habitat maps, Amirantes Archipelago (Seychelles), Western Indian Ocean

NASA Astrophysics Data System (ADS)

Hamylton, S.; Andréfouët, S.; Spencer, T.

2012-10-01

Increasing the use of geomorphological map products in marine spatial planning has the potential to greatly enhance return on mapping investment as they are commonly two orders of magnitude cheaper to produce than biologically-focussed maps of benthic communities and shallow substrates. The efficacy of geomorphological maps derived from remotely sensed imagery as surrogates for habitat diversity is explored by comparing two map sets of the platform reefs and atolls of the Amirantes Archipelago (Seychelles), Western Indian Ocean. One mapping campaign utilised Compact Airborne Spectrographic Imagery (19 wavebands, 1 m spatial resolution) to classify 11 islands and associated reefs into 25 biological habitat classes while the other campaign used Landsat 7 + ETM imagery (7 bands, 30 m spatial resolution) to generate maps of 14 geomorphic classes. The maps were compared across a range of characteristics, including habitat richness (number of classes mapped), diversity (Shannon-Weiner statistic) and thematic content (Cramer's V statistic). Between maps, a strong relationship was revealed for habitat richness (R2 = 0.76), a moderate relationship for class diversity and evenness (R2 = 0.63) and a variable relationship for thematic content, dependent on site complexity (V range 0.43-0.93). Geomorphic maps emerged as robust predictors of the habitat richness in the Amirantes. Such maps therefore demonstrate high potential value for informing coastal management activities and conservation planning by drawing on information beyond their own thematic content and thus maximizing the return on mapping investment.

Estimating B1+ in the breast at 7 T using a generic template.

PubMed

van Rijssel, Michael J; Pluim, Josien P W; Luijten, Peter R; Gilhuijs, Kenneth G A; Raaijmakers, Alexander J E; Klomp, Dennis W J

2018-05-01

Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B 1 + ) field inhomogeneities. B 1 + field information is required in order to correct these. The use of a generic, coil-specific B 1 + template is proposed and tested. Finite-difference time-domain simulations for B 1 + were performed for healthy female volunteers with a wide range of breast anatomies. A generic B 1 + template was constructed by averaging simulations based on four volunteers. Three-dimensional B 1 + maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B 1 + mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B 1 + mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B 1 + template. With local RF transmit coils, intersubject differences in B 1 + fields of the breast are comparable to the accuracy of B 1 + mapping methods, even at 7 T. Consequently, a single generic B 1 + template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B 1 + mapping protocol. © 2018 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

Estimating B 1 + in the breast at 7 T using a generic template

PubMed Central

Pluim, Josien P. W.; Luijten, Peter R.; Gilhuijs, Kenneth G. A.; Raaijmakers, Alexander J. E.; Klomp, Dennis W. J.

2018-01-01

Dynamic contrast‐enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B 1 +) field inhomogeneities. B 1 + field information is required in order to correct these. The use of a generic, coil‐specific B 1 + template is proposed and tested. Finite‐difference time‐domain simulations for B 1 + were performed for healthy female volunteers with a wide range of breast anatomies. A generic B 1 + template was constructed by averaging simulations based on four volunteers. Three‐dimensional B 1 + maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B 1 + mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00‐4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1‐16%, with mean 11.7%. The agreement between the proposed template approach and a B 1 + mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B 1 + template. With local RF transmit coils, intersubject differences in B 1 + fields of the breast are comparable to the accuracy of B 1 + mapping methods, even at 7 T. Consequently, a single generic B 1 + template suits subjects over a wide range of breast anatomies, eliminating the need for a time‐consuming B 1 + mapping protocol. PMID:29570887

Six easy steps on how to create a lean sigma value stream map for a multidisciplinary clinical operation.

PubMed

Lee, Emily; Grooms, Richard; Mamidala, Soumya; Nagy, Paul

2014-12-01

Value stream mapping (VSM) is a very useful technique to visualize and quantify the complex workflows often seen in clinical environments. VSM brings together multidisciplinary teams to identify parts of processes, collect data, and develop interventional ideas. An example involving pediatric MRI with general anesthesia VSM is outlined. As the process progresses, the map shows a large delay between the fax referral and the date of the scheduled and registered appointment. Ideas for improved efficiency and metrics were identified to measure improvement within a 6-month period, and an intervention package was developed for the department. Copyright © 2014. Published by Elsevier Inc.

Environmental study of ERTS-1 imagery: Lake Champlain and Vermont

NASA Technical Reports Server (NTRS)

Lind, A. O.; Henson, E. B.; Pelton, J. O.

1973-01-01

Environmental concerns of the State of Vermont currently being stressed include water quality in Lake Champlain and a state-wide land use and capability plan. Significant results obtained from ERTS-1 relate directly to the above concerns. Industrial water pollution and turbidity in Lake Champlain have been identified and mapped and the ERTS pollution data will be used in the developing court suit which Vermont has initiated against the polluters. ERTS imagery has also provided a foundation for updating and revising land use inventories. Major classes of land use have been identified and mapped, and substantial progress has been made toward the mapping of such land use divisions as crop and forest type, and wetlands.

Geological Mapping of the Lada Terra (V-56) Quadrangle, Venus: A Progress Report

NASA Technical Reports Server (NTRS)

Kumar, P. Senthil; Head, James W., III

2008-01-01

Geological mapping of the V-56 quadrangle (Fig. 1) reveals various tectonic and volcanic features and processes in Lada Terra that consist of tesserae, regional extensional belts, coronae, volcanic plains and impact craters. This study aims to map the spatial distribution of different material units, deformational features or lineament patterns and impact crater materials. In addition, we also establish the relative age relationships (e.g., overlapping or cross-cutting relationships) between them, in order to reconstruct the geologic history. Basically, this quadrangle addresses how coronae evolved in association with regional extensional belts, in addition to evolution of tesserae, regional plains and impact craters, which are also significant geological units of Lada Terra.

An Overview of the Topography of Mars from the Mars Orbiter Laser Altimeter (MOLA)

NASA Technical Reports Server (NTRS)

Smith, David E.; Zuber, Maria T.

2000-01-01

The Mars Global Surveyor (MGS) spacecraft has now completed more than half of its one-Mars-year mission to globally map Mars. During the MGS elliptical and circular orbit mapping phases, the Mars Orbiter Laser Altimeter (MOLA), an instrument on the MGS payload, has collected over 300 million precise elevation measurements. MOLA measures the range from the MGS spacecraft to the Martian surface and to atmospheric reflections. Range is converted to topography through knowledge of the MGS spacecraft orbit. Ranges from MOLA have resulted in a precise global topographic map of Mars. The instrument has also provided measurements of the width of the backscattered optical pulse and of the 1064 nm reflectivity of the Martian surface and atmosphere. The range resolution of the MOLA instrument is 37.5 cm and the along-track resolution of MOLA ground shots is approx. 300 m; the across-track spacing depends on latitude and time in the mapping orbit. The best current topographic grid has a spatial resolution of approx. 1/16 deg and vertical accuracy of approx. one meter. Additional information is contained in the original extended abstract.

Complete Bouguer gravity map of the Medicine Lake Quadrangle, California

USGS Publications Warehouse

Finn, C.

1981-01-01

A mathematical technique, called kriging, was programmed for a computer to interpolate hydrologic data based on a network of measured values in west-central Kansas. The computer program generated estimated values at the center of each 1-mile section in the Western Kansas Groundwater Management District No. 1 and facilitated contouring of selected values that are needed in the effective management of ground water for irrigation. The kriging technique produced objective and reproducible maps that illustrated hydrologic conditions in the Ogallala aquifer, the principal source of water in west-central Kansas. Maps of the aquifer, which use a 3-year average, included the 1978-80 water-table altitudes, which ranged from about 2,580 to 3,720 feet; the 1978-80 saturated thicknesses, which ranged from about 0 to 250 feet; and the percentage changes in saturated thickness from 1950 to 1978-80, which ranged from about a 50-percent increase to a 100-percent decrease. A map showing errors of estimate also was provided as a measure of reliability for the 1978-80 water-table altitudes. Errors of estimate ranged from 2 to 24 feet. (USGS)

Backwards compatible high dynamic range video compression

NASA Astrophysics Data System (ADS)

Dolzhenko, Vladimir; Chesnokov, Vyacheslav; Edirisinghe, Eran A.

2014-02-01

This paper presents a two layer CODEC architecture for high dynamic range video compression. The base layer contains the tone mapped video stream encoded with 8 bits per component which can be decoded using conventional equipment. The base layer content is optimized for rendering on low dynamic range displays. The enhancement layer contains the image difference, in perceptually uniform color space, between the result of inverse tone mapped base layer content and the original video stream. Prediction of the high dynamic range content reduces the redundancy in the transmitted data while still preserves highlights and out-of-gamut colors. Perceptually uniform colorspace enables using standard ratedistortion optimization algorithms. We present techniques for efficient implementation and encoding of non-uniform tone mapping operators with low overhead in terms of bitstream size and number of operations. The transform representation is based on human vision system model and suitable for global and local tone mapping operators. The compression techniques include predicting the transform parameters from previously decoded frames and from already decoded data for current frame. Different video compression techniques are compared: backwards compatible and non-backwards compatible using AVC and HEVC codecs.

Development and Implementation of Joint Programs in Laser Ranging and Other Space Geodetic Techniques

NASA Technical Reports Server (NTRS)

Pearlman, Michael R.; Carter, David (Technical Monitor)

2004-01-01

This progress report discusses the status and progress made in joint international programs including: 1) WEGENER; 2) Arabian Peninsula program; 3) Asia-Pacific Space Geodynamics (APSG) program; 4) the Fourteenth International Workshop on Laser Ranging; 5) the International Laser Ranging Service; and 6) current support for the NASA network.

Regulatory T cells in cattle and their potential role in bovine paratuberculosis.

PubMed

Coussens, Paul M; Sipkovsky, Sue; Murphy, Brooke; Roussey, Jon; Colvin, Christopher J

2012-05-01

The intracellular bacterium Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease in wild and domestic ruminants. Johne's disease presents as a chronic enteritis with severe inflammation of intestinal tissues, characterized by widespread infiltration of macrophages, the target cell of MAP. Clinical signs of Johne's disease are typically accompanied by a loss of peripheral CD4+ T cell responses to MAP antigens and an increase in anti-MAP serum IgG levels. Recently, it was proposed that regulatory T cells might develop over the lengthy course of subclinical MAP infection. In the past five years, significant progress in defining bovine regulatory T cells has been made. These studies grew out of observations that IL-10 is produced by PBMCs in response to MAP antigen stimulation and that neutralization of this IL-10 could enhance IFN-γ production from MAP-antigen reactive effector T cells. Depletion studies revealed that MAP responsive cell populations producing IL-10 were largely CD4+ and CD25+, although monocytes have also been shown to produce IL-10 in response to MAP. In addition, evidence for a regulatory population of γδ T cells has also begun to accumulate. We summarize current thinking regarding regulatory T cells in MAP infection and provide data suggesting a potential link between regulatory T cells, bovine leukemia virus, and MAP. Copyright © 2012 Elsevier Ltd. All rights reserved.

77 FR 46555 - Motor Carrier Safety Advisory Committee: Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-03

... provisions of the recently enacted Moving Ahead for Progress in the 21st Century (MAP-21) [Pub. L. 112-140... considered during the meeting by Wednesday, May 16, 2012, to Federal Docket Management System (FDMC) Docket...

MAPPING RATES ASSOCIATED WITH POLYGONS. (R827257)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Towards Direct Measurement of Ultrafast Vibrational Energy Flow in Proteins

NASA Astrophysics Data System (ADS)

Müller-Werkmeister, Henrike M.; Essig, Martin; Durkin, Patrick; Budisa, Nediljko; Bredenbeck, Jens

Vibrational energy transfer (VET) within a molecule can be investigated in great detail with ultrafast IR spectroscopy. We report on progress towards mapping of VET pathways in proteins using unnatural amino acids as site-specific probes.

Technical Data and Reports on Sulfur Dioxide (SO2) Measurements and SIP Status

EPA Pesticide Factsheets

EPA collects data from the states and regions on their air quality and state implementation plan (SIP) progress. This information is compiled in a database, and used to create reports, trend charts, and maps.

Upgraded airborne scanner for commercial remote sensing

NASA Astrophysics Data System (ADS)

Chang, Sheng-Huei; Rubin, Tod D.

1994-06-01

Traditional commercial remote sensing has focused on the geologic market, with primary focus on mineral identification and mapping in the visible through short-wave infrared spectral regions (0.4 to 2.4 microns). Commercial remote sensing users now demand airborne scanning capabilities spanning the entire wavelength range from ultraviolet through thermal infrared (0.3 to 12 microns). This spectral range enables detection, identification, and mapping of objects and liquids on the earth's surface and gases in the air. Applications requiring this range of wavelengths include detection and mapping of oil spills, soil and water contamination, stressed vegetation, and renewable and non-renewable natural resources, and also change detection, natural hazard mitigation, emergency response, agricultural management, and urban planning. GER has designed and built a configurable scanner that acquires high resolution images in 63 selected wave bands in this broad wavelength range.

Range image registration based on hash map and moth-flame optimization

NASA Astrophysics Data System (ADS)

Zou, Li; Ge, Baozhen; Chen, Lei

2018-03-01

Over the past decade, evolutionary algorithms (EAs) have been introduced to solve range image registration problems because of their robustness and high precision. However, EA-based range image registration algorithms are time-consuming. To reduce the computational time, an EA-based range image registration algorithm using hash map and moth-flame optimization is proposed. In this registration algorithm, a hash map is used to avoid over-exploitation in registration process. Additionally, we present a search equation that is better at exploration and a restart mechanism to avoid being trapped in local minima. We compare the proposed registration algorithm with the registration algorithms using moth-flame optimization and several state-of-the-art EA-based registration algorithms. The experimental results show that the proposed algorithm has a lower computational cost than other algorithms and achieves similar registration precision.

Fusion of Terrestrial and Airborne Laser Data for 3D modeling Applications

NASA Astrophysics Data System (ADS)

Mohammed, Hani Mahmoud

This thesis deals with the 3D modeling phase of the as-built large BIM projects. Among several means of BIM data capturing, such as photogrammetric or range tools, laser scanners have been one of the most efficient and practical tool for a long time. They can generate point clouds with high resolution for 3D models that meet nowadays' market demands. The current 3D modeling projects of as-built BIMs are mainly focused on using one type of laser scanner data, such as Airborne or Terrestrial. According to the literatures, no significant (few) efforts were made towards the fusion of heterogeneous laser scanner data despite its importance. The importance of the fusion of heterogeneous data arises from the fact that no single type of laser data can provide all the information about BIM, especially for large BIM projects that are existing on a large area, such as university buildings, or Heritage places. Terrestrial laser scanners are able to map facades of buildings and other terrestrial objects. However, they lack the ability to map roofs or higher parts in the BIM project. Airborne laser scanner on the other hand, can map roofs of the buildings efficiently and can map only small part of the facades. Short range laser scanners can map the interiors of the BIM projects, while long range scanners are used for mapping wide exterior areas in BIM projects. In this thesis the long range laser scanner data obtained in the Stop-and-Go mapping mode, the short range laser scanner data, obtained in a fully static mapping mode, and the airborne laser data are all fused together to bring a complete effective solution for a large BIM project. Working towards the 3D modeling of BIM projects, the thesis framework starts with the registration of the data, where a new fast automatic registration algorithm were developed. The next step is to recognize the different objects in the BIM project (classification), and obtain 3D models for the buildings. The last step is the development of an occlusion removal algorithm to efficiently retain parts of the buildings occluded by surrounding objects such as trees, vehicles, or street poles.

Testing statistical isotropy in cosmic microwave background polarization maps

NASA Astrophysics Data System (ADS)

Rath, Pranati K.; Samal, Pramoda Kumar; Panda, Srikanta; Mishra, Debesh D.; Aluri, Pavan K.

2018-04-01

We apply our symmetry based Power tensor technique to test conformity of PLANCK Polarization maps with statistical isotropy. On a wide range of angular scales (l = 40 - 150), our preliminary analysis detects many statistically anisotropic multipoles in foreground cleaned full sky PLANCK polarization maps viz., COMMANDER and NILC. We also study the effect of residual foregrounds that may still be present in the Galactic plane using both common UPB77 polarization mask, as well as the individual component separation method specific polarization masks. However, some of the statistically anisotropic modes still persist, albeit significantly in NILC map. We further probed the data for any coherent alignments across multipoles in several bins from the chosen multipole range.

MAPS OF THE MAGELLANIC CLOUDS FROM COMBINED SOUTH POLE TELESCOPE AND PLANCK DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, T. M.; Benson, B. A.; Bleem, L. E.

We present maps of the Large and Small Magellanic Clouds from combined South Pole Telescope (SPT) and Planck data. The Planck satellite observes in nine bands, while the SPT data used in this work were taken with the three-band SPT-SZ camera, The SPT-SZ bands correspond closely to three of the nine Planck bands, namely those centered at 1.4, 2.1, and 3.0 mm. The angular resolution of the Planck data ranges from 5 to 10 arcmin, while the SPT resolution ranges from 1.0 to 1.7 arcmin. The combined maps take advantage of the high resolution of the SPT data and themore » long-timescale stability of the space-based Planck observations to deliver robust brightness measurements on scales from the size of the maps down to ∼1 arcmin. In each band, we first calibrate and color-correct the SPT data to match the Planck data, then we use noise estimates from each instrument and knowledge of each instrument’s beam to make the inverse-variance-weighted combination of the two instruments’ data as a function of angular scale. We create maps assuming a range of underlying emission spectra and at a range of final resolutions. We perform several consistency tests on the combined maps and estimate the expected noise in measurements of features in them. We compare maps from this work to those from the Herschel HERITAGE survey, finding general consistency between the data sets. All data products described in this paper are available for download from the NASA Legacy Archive for Microwave Background Data Analysis server.« less

Geological Survey research 1981

USGS Publications Warehouse

,

1982-01-01

This U.S. Geological Survey activities report includes a summary of 1981 fiscal year scientific and economic results accompanied by a list of geologic, hydrologic, and cartographic investigations in progress. The summary of results includes: (1) Mineral, (2) Water resources, (3) Engineering geology and hydrology, (4) Regional geology, (5) Principles and processes, (6) Laboratory and field methods, (7) Topographic surveys and mapping, (8) Management of resources on public lands, (9) Land information and analysis, and (10) Investigations in other countries. Also included are lists of investigations in progress.

Magician Simulator. A Realistic Simulator for Heterogenous Teams of Autonomous Robots

DTIC Science & Technology

2011-01-18

IMU, and LIDAR systems for identifying and tracking mobile OOI at long range (>20m), providing early warnings and allowing neutralization from a... LIDAR and Computer Vision template-based feature tracking approaches. Mapping was solved through Multi-Agent particle-filter based Simultaneous...Locali- zation and Mapping ( SLAM ). Our system contains two maps, a physical map and an influence map (location of hostile OOI, explored and unexplored

EGRET Diffuse Gamma Ray Maps Between 30 MeV and 10 GeV

NASA Technical Reports Server (NTRS)

Cillis, A, N.; Hartman, R. C.

2004-01-01

This paper presents all-sky maps of diffuse gamma radiation in various energy ranges between 30 MeV and 10 GeV, based on data collected by the EGRET instrument on the Compton Gamma Ray Observatory. Although the maps can be used for a variety of applications. the immediate goal is the generation of diffuse gamma-ray maps which can be used as a diffuse background/foreground for point source analysis of the data to be obtained from new high-energy gamma-ray missions like GLAST and AGILE. To generate the diffuse gamma maps from the raw EGRET maps, the point sources in the Third EGRET Catalog were subtracted out using the appropriate point spread function for each energy range. After that, smoothing was performed to minimize the effects of photon statistical noise. A smoothing length of 1 deg vas used for the Galactic plane maps. For the all-sky maps, a procedure was used which resulted in a smoothing length roughly equivalent to 4 deg. The result of this work is 16 maps of different energy intervals for absolute value of b < or equal to 20 deg, and 32 all-sky maps, 16 in equatorial coordinates (J2000) and 16 in Galactic coordinates.

EGRET Diffuse Gamma Ray Maps Between 30 MeV and 10 GeV

NASA Technical Reports Server (NTRS)

Cillis, A. N.; Hartman, R. C.

2004-01-01

This paper presents all-sky maps of diffuse gamma radiation in various energy ranges between 30 MeV and 10 GeV, based on data collected by the EGRET instrument on the Compton Gamma Ray Observatory. Although the maps can be used for a variety of applications, the immediate goal is the generation of diffuse gamma-ray maps which can be used as a diffuse background/foreground for point source analysis of the data to be obtained from new high-energy gamma-ray missions like GLAST and AGILE. To generate the diffuse gamma maps from the raw EGRET maps, the point sources in the Third EGRET Catalog were subtracted out using the appropriate point spread function for each energy range. After that, smoothing was performed to minimize the effects of photon statistical noise. A smoothing length of 1deg was used for the Galactic plane maps. For the all-sky maps, a procedure was used which resulted in a smoothing length roughly equivalent to 4deg. The result of this work is 16 maps of different energy intervals for [b]less than or equal to 20deg, and 32 all-sky maps, 16 in equatorial coordinates (J2000) and 16 in Galactic coordinates.

An imputed forest composition map for New England screened by species range boundaries

Treesearch

Matthew J. Duveneck; Jonathan R. Thompson; B. Tyler Wilson

2015-01-01

Initializing forest landscape models (FLMs) to simulate changes in tree species composition requires accurate fine-scale forest attribute information mapped continuously over large areas. Nearest-neighbor imputation maps, maps developed from multivariate imputation of field plots, have high potential for use as the initial condition within FLMs, but the tendency for...

High Quality Genomic Copy Number Data from Archival Formalin-Fixed Paraffin-Embedded Leiomyosarcoma: Optimisation of Universal Linkage System Labelling

PubMed Central

Salawu, Abdulazeez; Ul-Hassan, Aliya; Hammond, David; Fernando, Malee; Reed, Malcolm; Sisley, Karen

2012-01-01

Most soft tissue sarcomas are characterized by genetic instability and frequent genomic copy number aberrations that are not subtype-specific. Oligonucleotide microarray-based Comparative Genomic Hybridisation (array CGH) is an important technique used to map genome-wide copy number aberrations, but the traditional requirement for high-quality DNA typically obtained from fresh tissue has limited its use in sarcomas. Although large archives of Formalin-fixed Paraffin-embedded (FFPE) tumour samples are available for research, the degradative effects of formalin on DNA from these tissues has made labelling and analysis by array CGH technically challenging. The Universal Linkage System (ULS) may be used for a one-step chemical labelling of such degraded DNA. We have optimised the ULS labelling protocol to perform aCGH on archived FFPE leiomyosarcoma tissues using the 180k Agilent platform. Preservation age of samples ranged from a few months to seventeen years and the DNA showed a wide range of degradation (when visualised on agarose gels). Consistently high DNA labelling efficiency and low microarray probe-to-probe variation (as measured by the derivative log ratio spread) was seen. Comparison of paired fresh and FFPE samples from identical tumours showed good correlation of CNAs detected. Furthermore, the ability to macro-dissect FFPE samples permitted the detection of CNAs that were masked in fresh tissue. Aberrations were visually confirmed using Fluorescence in situ Hybridisation. These results suggest that archival FFPE tissue, with its relative abundance and attendant clinical data may be used for effective mapping for genomic copy number aberrations in such rare tumours as leiomyosarcoma and potentially unravel clues to tumour origins, progression and ultimately, targeted treatment. PMID:23209738

Mapping the Substellar Mass-Luminosity Relation Down to the L/T Transition

NASA Astrophysics Data System (ADS)

Dupuy, Trent

2016-10-01

Substellar models underpin our theoretical understanding of brown dwarfs and gas-giant exoplanets, so assessing their accuracy is paramount. The past several years have seen progress in testing models thanks to a growing number of dynamical (total) masses for brown dwarf binaries determined via (relative) orbit monitoring from ground-based AO. However, the strongest tests of models require individual masses, particularly for calibrating the mass-luminosity relation. This is poorly constrained over the range of spectral types most influenced by clouds (mid-L to early-T). Given the observed prevalence of clouds in the atmospheres of directly imaged planets, testing models at such temperatures is crucial.We propose a 3-year program to obtain individual masses for a sample of 11 substellar binaries. Our proposal builds on nearly a decade of orbital monitoring from the ground to measure dynamical total masses. Our goal is thus to measure precise mass ratios, utilizing HST's unique wide-field, high-angular resolution astrometric capabilities. We will obtain WFC3-UVIS images capturing our targets and numerous reference stars so that we can measure the relative amount of orbital motion in each component to determine mass ratios. Three of our targets have I-band photocenter orbits measured at USNO and VLT and thus only require one epoch of resolved I-band imaging to unlock individual masses. We will use this first large sample of substellar individual masses to map out the mass-luminosity relation over a wide range of temperatures (1000-2000 K) including the L/T transition. This will become a touchstone sample for tests of ultracool atmospheric models in the era of JWST.

Mapping the Substellar Mass-Luminosity Relation Down to the L/T Transition

NASA Astrophysics Data System (ADS)

Dupuy, Trent

2017-08-01

Substellar models underpin our theoretical understanding of brown dwarfs and gas-giant exoplanets, so assessing their accuracy is paramount. The past several years have seen progress in testing models thanks to a growing number of dynamical (total) masses for brown dwarf binaries determined via (relative) orbit monitoring from ground-based AO. However, the strongest tests of models require individual masses, particularly for calibrating the mass-luminosity relation. This is poorly constrained over the range of spectral types most influenced by clouds (mid-L to early-T). Given the observed prevalence of clouds in the atmospheres of directly imaged planets, testing models at such temperatures is crucial.We propose a 3-year program to obtain individual masses for a sample of 11 substellar binaries. Our proposal builds on nearly a decade of orbital monitoring from the ground to measure dynamical total masses. Our goal is thus to measure precise mass ratios, utilizing HST's unique wide-field, high-angular resolution astrometric capabilities. We will obtain WFC3-UVIS images capturing our targets and numerous reference stars so that we can measure the relative amount of orbital motion in each component to determine mass ratios. Three of our targets have I-band photocenter orbits measured at USNO and VLT and thus only require one epoch of resolved I-band imaging to unlock individual masses. We will use this first large sample of substellar individual masses to map out the mass-luminosity relation over a wide range of temperatures (1000-2000 K) including the L/T transition. This will become a touchstone sample for tests of ultracool atmospheric models in the era of JWST.

Moving California Ahead: An Executive Summary Concerning Two Commission Higher Education Long-Range Planning Reports, Providing for Progress and Policy for Progress.

ERIC Educational Resources Information Center

California State Postsecondary Education Commission, Sacramento.

This is an executive summary of two long-range higher education planning reports completed at the outset of the 21st century by the California Postsecondary Education Commission. They are "Providing for Progress: California Higher Education Enrollment Demand and Resources into the 21st Century" and the companion "Policy for…

Evaluation of the relationship between T1ρ and T2 values and patella cartilage degeneration in patients of the same age group.

PubMed

Nishioka, Hiroaki; Hirose, Jun; Okamoto, Nobukazu; Okada, Tatsuya; Oka, Kiyoshi; Taniwaki, Takuya; Nakamura, Eiichi; Yamashita, Yasuyuki; Mizuta, Hiroshi

2015-03-01

The aim of this study was to investigate the association between the T1ρ and T2 values and the progression of cartilage degeneration in patients of the same age group. Sagittal T1ρ and T2 mapping and three-dimensional (3D) gradient-echo images were obtained from 78 subjects with medial knee osteoarthritis (OA). The degree of patella cartilage degeneration was classified into four groups using MRI-based grading: apparently normal cartilage, mild OA, moderate OA, and severe OA group. We measured the T1ρ and T2 values (ms) in the regions of interest set on the full-thickness patella cartilage. Then, we analyzed the relationship between the T1ρ and T2 values and the degree of patella cartilage degeneration. There were no significant differences in age among the four groups. Both the T1ρ and T2 values showed a positive correlation with the degree of OA progression (ρ=0.737 and ρ=0.632, respectively). By comparison between the apparently normal cartilage and the mild OA groups, there were significant differences in the T1ρ mapping, but not in the T2 mapping. Our study confirmed that T1ρ and T2 mapping can quantitatively evaluate the degree of patella cartilage degeneration in patients within the same age group. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Preliminary Geologic Map of the Vermejo Peak area, Colfax and Taos Counties, New Mexico and Las Animas and Costilla Counties, Colorado

USGS Publications Warehouse

Fridrich, Christopher J.; Shroba, Ralph R.; Pillmore, Charles L.; Hudson, Adam M.

2009-01-01

This geologic map covers four 7.5-minute quadrangles-The Wall, NM-CO (New Mexico-Colorado), Vermejo Park, NM-CO, Ash Mountain, NM, and Van Bremmer Park, NM. The study area straddles the boundary between the eastern flank of the Sangre de Cristo Mountains and the western margin of the Raton Basin, with about two-thirds of the map area in the basin. The Raton Basin is a foreland basin that formed immediately eastward of the Sangre de Cristo Mountains during their initial uplift, in the Late Cretaceous through early Eocene Laramide orogeny. Subsequently, these mountains have been extensively modified during formation of the Rio Grande rift, from late Oligocene to present. The map area is within that part of the Sangre de Cristo Mountains that is called the Culebra Range. Additionally, the map covers small parts of the Devil's Park graben and the Valle Vidal half-graben, in the northwestern and southwestern parts of the map area, respectively. These two grabens are small intermontaine basins, that are satellitic to the main local basin of the Rio Grande rift, the San Luis Basin, that are an outlying, early- formed part of the rift, and that separate the Culebra Range from the Taos Range, to the southwest.

Elemental mapping of large samples by external ion beam analysis with sub-millimeter resolution and its applications

NASA Astrophysics Data System (ADS)

Silva, T. F.; Rodrigues, C. L.; Added, N.; Rizzutto, M. A.; Tabacniks, M. H.; Mangiarotti, A.; Curado, J. F.; Aguirre, F. R.; Aguero, N. F.; Allegro, P. R. P.; Campos, P. H. O. V.; Restrepo, J. M.; Trindade, G. F.; Antonio, M. R.; Assis, R. F.; Leite, A. R.

2018-05-01

The elemental mapping of large areas using ion beam techniques is a desired capability for several scientific communities, involved on topics ranging from geoscience to cultural heritage. Usually, the constraints for large-area mapping are not met in setups employing micro- and nano-probes implemented all over the world. A novel setup for mapping large sized samples in an external beam was recently built at the University of São Paulo employing a broad MeV-proton probe with sub-millimeter dimension, coupled to a high-precision large range XYZ robotic stage (60 cm range in all axis and precision of 5 μ m ensured by optical sensors). An important issue on large area mapping is how to deal with the irregularities of the sample's surface, that may introduce artifacts in the images due to the variation of the measuring conditions. In our setup, we implemented an automatic system based on machine vision to correct the position of the sample to compensate for its surface irregularities. As an additional benefit, a 3D digital reconstruction of the scanned surface can also be obtained. Using this new and unique setup, we have produced large-area elemental maps of ceramics, stones, fossils, and other sort of samples.

Status of shallow-aquifer mapping in the Northern Front Range Area, Colorado

USGS Publications Warehouse

Robson, Stanley G.

2001-01-01

Mapping of shallow aquifers in the northern Front Range area of Colorado has been completed as part of the U.S. Geological Survey Front Range Infrastructure Resources Project. The aquifer mapping was undertaken as part of a comprehensive effort to better define the mineral, energy, cartographic, biological, and water resources that are critical to the support and development of the area's infrastructure, such as streets. highways, airports, and buildings. The aquifer mapping was undertaken in cooperation with the Colorado Division of Water Resources and the Colorado Water Conservation Board. The shallow aquifers have been mapped in a 2,450-square-mile area extending as an approximately 30-mile-wide band from north of Fort Collins to the Arapahoe-Douglas County line south of Denver (fig. I). The shallow aquifer mapping in the Denver metropolitan area was published in 1996 as Hydrologic Investigations Atlas HA-736 (Robson. 1996). Shallow aquifer mapping in the Greeley-Nunn area was published as HA-746A (Robson, Arnold, and Heiny, 2000a); mapping in the Fort Collins-Loveland area was published as HA-746B (Robson, Arnold, and Heiny, 2000b); mapping in the Fort Lupton-Gilcrest area was published as HA-746C (Robson, Heiny, and Arnold, 2000c); and mapping in the Boulder-Longmont area was published as HA-746D (Robson, Heiny, and Arnold, 2000d). Each of the five atlases contains five map sheets at 1:50,000 scale showing: 1. The thickness and extent of the unconsolidated sediments (loose gravel. sand. silt, and clay) that overlie the bedrock formations in the area (fig. 2). 2. The altitude and configuration of the bedrock surface. 3. The altitude of the water table and direction of ground-water movement. 4. The saturated thickness of the shallow aquifers. 5. The depth to the water table in the shallow aquifers.

Project UCARE : Uniform Commuter Assistance Reporting and Evaluation for transportation demand management programs, [summary].

DOT National Transportation Integrated Search

2013-09-01

The federal transportation reauthorization called : Moving Ahead for Progress in the 21st Century Act : (MAP-21) creates a program that addresses many : challenges facing the U.S. transportation system. : These challenges include improving safety, : ...

Impact of the legalization and decriminalization of marijuana on the DWI system.

DOT National Transportation Integrated Search

2017-06-01

In Moving Ahead for Progress in the 21st Century (MAP-21) Act, Congress directed NHTSA to establish a cooperative programthe National Cooperative Research and Evaluation Program (NCREP)to conduct research and evaluations of State highway safety...

USDOT Tier 1 University Transportation Center Program progress performance report #5.

DOT National Transportation Integrated Search

2016-04-29

MarTREC is a USDOT Tier 1 University Transportation Center funded in September 30, 2013 : under MAP-21. Our consortium consists of the University of Arkansas (UARK), Fayetteville, AR; : Jackson State University (JSU), Jackson, MS; Louisiana State Uni...

Considerations for calculating arterial system performance measures in Virginia.

DOT National Transportation Integrated Search

2017-02-01

The Moving Ahead for Progress in the 21st Century Act (MAP-21) mandates that state departments of transportation monitor and report performance measures in several areas. System performance measures on the National Highway System (NHS) are part of th...

INFORMING THE POLICY PROCESS WITH COGNITIVE MAPPING. (R825791)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Longitudinal atlas for normative human brain development and aging over the lifespan using quantitative susceptibility mapping.

PubMed

Zhang, Yuyao; Wei, Hongjiang; Cronin, Matthew J; He, Naying; Yan, Fuhua; Liu, Chunlei

2018-05-01

Longitudinal brain atlases play an important role in the study of human brain development and cognition. Existing atlases are mainly based on anatomical features derived from T1-and T2-weighted MRI. A 4D developmental quantitative susceptibility mapping (QSM) atlas may facilitate the estimation of age-related iron changes in deep gray matter nuclei and myelin changes in white matter. To this end, group-wise co-registered QSM templates were generated over various age intervals from age 1-83 years old. Registration was achieved by combining both T1-weighted and QSM images. Based on the proposed template, we created an accurate deep gray matter nuclei parcellation map (DGM map). Notably, we segmented thalamus into 5 sub-regions, i.e. the anterior nuclei, the median nuclei, the lateral nuclei, the pulvinar and the internal medullary lamina. Furthermore, we built a "whole brain QSM parcellation map" by combining existing cortical parcellation and white-matter atlases with the proposed DGM map. Based on the proposed QSM atlas, the segmentation accuracy of iron-rich nuclei using QSM is significantly improved, especially for children and adolescent subjects. The age-related progression of magnetic susceptibility in each of the deep gray matter nuclei, the hippocampus, and the amygdala was estimated. Our automated atlas-based analysis provided a systematic confirmation of previous findings on susceptibility progression with age resulting from manual ROI drawings in deep gray matter nuclei. The susceptibility development in the hippocampus and the amygdala follow an iron accumulation model; while in the thalamus sub-regions, the susceptibility development exhibits a variety of trends. It is envisioned that the newly developed 4D QSM atlas will serve as a template for studying brain iron deposition and myelination/demyelination in both normal aging and various brain diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

Nanomechanics of Cells and Biomaterials Studied by Atomic Force Microscopy.

PubMed

Kilpatrick, Jason I; Revenko, Irène; Rodriguez, Brian J

2015-11-18

The behavior and mechanical properties of cells are strongly dependent on the biochemical and biomechanical properties of their microenvironment. Thus, understanding the mechanical properties of cells, extracellular matrices, and biomaterials is key to understanding cell function and to develop new materials with tailored mechanical properties for tissue engineering and regenerative medicine applications. Atomic force microscopy (AFM) has emerged as an indispensable technique for measuring the mechanical properties of biomaterials and cells with high spatial resolution and force sensitivity within physiologically relevant environments and timescales in the kPa to GPa elastic modulus range. The growing interest in this field of bionanomechanics has been accompanied by an expanding array of models to describe the complexity of indentation of hierarchical biological samples. Furthermore, the integration of AFM with optical microscopy techniques has further opened the door to a wide range of mechanotransduction studies. In recent years, new multidimensional and multiharmonic AFM approaches for mapping mechanical properties have been developed, which allow the rapid determination of, for example, cell elasticity. This Progress Report provides an introduction and practical guide to making AFM-based nanomechanical measurements of cells and surfaces for tissue engineering applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

X-ray Pulsars Across the Parameter Space of Luminosity, Accretion Mode, and Spin

NASA Astrophysics Data System (ADS)

Laycock, Silas; Yang, Jun; Christodoulou, Dimitris; Coe, Malcolm; Cappallo, Rigel; Zezas, Andreas; Ho, Wynn C. G.; Hong, JaeSub; Fingerman, Samuel; Drake, Jeremy J.; Kretschmar, Peter; Antoniou, Vallia

2017-08-01

We present our multi-satellite library of X-ray Pulsar observations to the community, and highlight recent science results. Available at www.xraypulsars.space the library provides a range of high-level data products, including: activity histories, pulse-profiles, phased event files, and a unique pulse-profile modeling interface. The initial release (v1.0) contains some 15 years of RXTE-PCA, Chandra ACIS-I, and XMM-PN observations of the Small Magellanic Cloud, creating a valuable record of pulsar behavior. Our library is intended to enable new progress on fundamental NS parameters and accretion physics. The major motivations are (1) Assemble a large homogeneous sample to enable population statistics. This has so far been used to map the propeller transition, and explore the role of retrograde and pro-grade accretion disks. (2) Obtain pulse-profiles for the same pulsars on many different occasions, at different luminosities and states in order to break model degeneracies. This effort has led to preliminary measurements of the offsets between magnetic and spin axes. With the addition of other satellites, and Galactic pulsars, the library will cover the entire available range of luminosity, variability timescales and accretion regimes.

The need for sustained and integrated high-resolution mapping of dynamic coastal environments

USGS Publications Warehouse

Stockdon, Hilary F.; Lillycrop, Jeff W.; Howd, Peter A.; Wozencraft, Jennifer M.

2007-01-01

The evolution of the United States' coastal zone response to both human activities and natural processes is dynamic. Coastal resource and population protection requires understanding, in detail, the processes needed for change as well as the physical setting. Sustained coastal area mapping allows change to be documented and baseline conditions to be established, as well as future behavior to be predicted in conjunction with physical process models. Hyperspectral imagers and airborne lidars, as well as other recent mapping technology advances, allow rapid national scale land use information and high-resolution elevation data collection. Coastal hazard risk evaluation has critical dependence on these rich data sets. A fundamental storm surge model parameter in predicting flooding location, for example, is coastal elevation data, and a foundation in identifying the most vulnerable populations and resources is land use maps. A wealth of information for physical change process study, coastal resource and community management and protection, and coastal area hazard vulnerability determination, is available in a comprehensive national coastal mapping plan designed to take advantage of recent mapping technology progress and data distribution, management, and collection.

Compensated geothermal gradient: new map of old data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ibrahim, M.W.

1986-05-01

Bottom-hole temperature measurement is one of the oldest forms of downhole information acquired by the oil industry. Old and new geothermal maps that are based on these measurements have invariably been drawn with an assumed constant or average ground surface temperature over the mapped areas. However, near ground-surface equilibrium temperature is a variable rather than a constant over any region; therefore, old and current geothermal gradient mapping methods give a false impression of the true thermal level of subsurface strata, and may lead to erroneous results of temperature-based calculations, such as the TTI. In this paper, a geothermal mapping methodmore » is presented in which extrapolated surface temperature is coupled with the corresponding geothermal gradient over the mapped area. The method was tested on areas in the Middle East and Africa. Results indicate that it is especially effective in delineating loci of vertical geothermal heat flux carried upwards by ascending subsurface fluids; such areas are preferential sites for hydrocarbon entrapment, especially in young sedimentary basins where migration is still in progress.« less

Age discrimination among eruptives of Menengai Caldera, Kenya, using vegetation parameters from satellite imagery

NASA Technical Reports Server (NTRS)

Blodget, Herbert W.; Heirtzler, James R.

1993-01-01

Results are presented of an investigation to determine the degree to which digitally processed Landsat TM imagery can be used to discriminate among vegetated lava flows of different ages in the Menengai Caldera, Kenya. A selective series of five images, consisting of a color-coded Landsat 5 classification and four color composites, are compared with geologic maps. The most recent of more than 70 postcaldera flows within the caldera are trachytes, which are variably covered by shrubs and subsidiary grasses. Soil development evolves as a function of time, and as such supports a changing plant community. Progressively older flows exhibit the increasing dominance of grasses over bushes. The Landsat images correlated well with geologic maps, but the two mapped age classes could be further subdivided on the basis of different vegetation communities. It is concluded that field maps can be modified, and in some cases corrected by use of such imagery, and that digitally enhanced Landsat imagery can be a useful aid to field mapping in similar terrains.

Soils of Walker Branch Watershed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lietzke, D.A.

1994-03-01

The soil survey of Walker Branch Watershed (WBW) utilized the most up-to-date knowledge of soils, geology, and geohydrology in building the soils data base needed to reinterpret past research and to begin new research in the watershed. The soils of WBW were also compared with soils mapped elsewhere along Chestnut Ridge on the Oak Ridge Reservation to (1) establish whether knowledge obtained elsewhere could be used within the watershed, (2) determine whether there were any soils restricted to the watershed, and (3) evaluate geologic formation lateral variability. Soils, surficial geology, and geomorphology were mapped at a scale of 1:1,200 usingmore » a paper base map having 2-ft contour intervals. Most of the contours seemed to reasonably represent actual landform configurations, except for dense wooded areas. For example, the very large dolines or sinkholes were shown on the contour base map, but numerous smaller ones were not. In addition, small drainageways and gullies were often not shown. These often small but important features were located approximately as soil mapping progressed.« less

Hyperbolic Harmonic Mapping for Surface Registration

PubMed Central

Shi, Rui; Zeng, Wei; Su, Zhengyu; Jiang, Jian; Damasio, Hanna; Lu, Zhonglin; Wang, Yalin; Yau, Shing-Tung; Gu, Xianfeng

2016-01-01

Automatic computation of surface correspondence via harmonic map is an active research field in computer vision, computer graphics and computational geometry. It may help document and understand physical and biological phenomena and also has broad applications in biometrics, medical imaging and motion capture inducstries. Although numerous studies have been devoted to harmonic map research, limited progress has been made to compute a diffeomorphic harmonic map on general topology surfaces with landmark constraints. This work conquers this problem by changing the Riemannian metric on the target surface to a hyperbolic metric so that the harmonic mapping is guaranteed to be a diffeomorphism under landmark constraints. The computational algorithms are based on Ricci flow and nonlinear heat diffusion methods. The approach is general and robust. We employ our algorithm to study the constrained surface registration problem which applies to both computer vision and medical imaging applications. Experimental results demonstrate that, by changing the Riemannian metric, the registrations are always diffeomorphic and achieve relatively high performance when evaluated with some popular surface registration evaluation standards. PMID:27187948

Application of a new genetic classification and semi-automated geomorphic mapping approach in the Perth submarine canyon, Australia

NASA Astrophysics Data System (ADS)

Picard, K.; Nanson, R.; Huang, Z.; Nichol, S.; McCulloch, M.

2017-12-01

The acquisition of high resolution marine geophysical data has intensified in recent years (e.g. multibeam echo-sounding, sub-bottom profiling). This progress provides the opportunity to classify and map the seafloor in greater detail, using new methods that preserve the links between processes and morphology. Geoscience Australia has developed a new genetic classification approach, nested within the Harris et al (2014) global seafloor mapping framework. The approach divides parent units into sub-features based on established classification schemes and feature descriptors defined by Bradwell et al. (2016: http://nora.nerc.ac.uk/), the International Hydrographic Organization (https://www.iho.int) and the Coastal Marine and Ecological Classification Standard (https://www.cmecscatalog.org). Owing to the ecological significance of submarine canyon systems in particular, much recent attention has focused on defining their variation in form and process, whereby they can be classified using a range of topographic metrics, fluvial dis/connection and shelf-incising status. The Perth Canyon is incised into the continental slope and shelf of southwest Australia, covering an area of >1500 km2 and extending from 4700 m water depth to the shelf break in 170 m. The canyon sits within a Marine Protected Area, incorporating a Marine National Park and Habitat Protection Zone in recognition of its benthic and pelagic biodiversity values. However, detailed information of the spatial patterns of the seabed habitats that influence this biodiversity is lacking. Here we use 20 m resolution bathymetry and acoustic backscatter data acquired in 2015 by the Schmidt Ocean Institute plus sub-bottom datasets and sediment samples collected Geoscience Australia in 2005 to apply the new geomorphic classification system to the Perth Canyon. This presentation will show the results of the geomorphic feature mapping of the canyon and its application to better defining potential benthic habitats.

Data annotation, recording and mapping system for the US open skies aircraft

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, B.W.; Goede, W.F.; Farmer, R.G.

1996-11-01

This paper discusses the system developed by Northrop Grumman for the Defense Nuclear Agency (DNA), US Air Force, and the On-Site Inspection Agency (OSIA) to comply with the data annotation and reporting provisions of the Open Skies Treaty. This system, called the Data Annotation, Recording and Mapping System (DARMS), has been installed on the US OC-135 and meets or exceeds all annotation requirements for the Open Skies Treaty. The Open Skies Treaty, which will enter into force in the near future, allows any of the 26 signatory countries to fly fixed wing aircraft with imaging sensors over any of themore » other treaty participants, upon very short notice, and with no restricted flight areas. Sensor types presently allowed by the treaty are: optical framing and panoramic film cameras; video cameras ranging from analog PAL color television cameras to the more sophisticated digital monochrome and color line scanning or framing cameras; infrared line scanners; and synthetic aperture radars. Each sensor type has specific performance parameters which are limited by the treaty, as well as specific annotation requirements which must be achieved upon full entry into force. DARMS supports U.S. compliance with the Opens Skies Treaty by means of three subsystems: the Data Annotation Subsytem (DAS), which annotates sensor media with data obtained from sensors and the aircraft`s avionics system; the Data Recording System (DRS), which records all sensor and flight events on magnetic media for later use in generating Treaty mandated mission reports; and the Dynamic Sensor Mapping Subsystem (DSMS), which provides observers and sensor operators with a real-time moving map displays of the progress of the mission, complete with instantaneous and cumulative sensor coverages. This paper will describe DARMS and its subsystems in greater detail, along with the supporting avionics sub-systems. 7 figs.« less

The use of Global Positioning System units and ArcGIS Online to engage K-12 Students in Research Being Done in their Local Communities

NASA Astrophysics Data System (ADS)

Butcher, C. E.; Sparrow, E. B.; Clucas, T.

2015-12-01

Incorporating K-12 students in scientific research processes and opportunities in their communities is a great way to bridge the gap between research and education and to start building science research capacity at an early age. One goal of the Experimental Program to Stimulate Competitive Research (EPSCoR) Alaska Adapting to Changing Environments project is to engage the local community in the research as well as to share results with the people. By giving K-12 students Global Positioning System (GPS) units, and allowing them to collect and map their own data, they are being exposed to some of the research methods being used by scientists in the Alaska ACE project. This hands-on, minds-on method has been successfully used in formal education settings such as a Junior High School classroom in Nuiqsut, Alaska as well as in informal education settings such as summer camps in Barrow, Alaska and Kenai, Alaska. The students progress from mapping by hand to collecting location data with their GPS units and cameras, and imputing this information into ArcGIS Online to create map products. The data collected were from sites ranging from important places in the community to sites visited during summer camps, with students reflecting on data and site significance. Collecting data, using technology, and creating map products contribute to science skills and practices students need to conduct research of their own and to understand research being done around them. The goal of this education outreach implementation is to bring students closer to the research, understand the process of science, and have the students continue to collect data and contribute to research in their communities. Support provided for this work from the Alaska EPSCoR NSF Award #OIA-1208927 and the state of Alaska is gratefully acknowledged.

Geologic map of the Weldona 7.5' quadrangle, Morgan County, Colorado

USGS Publications Warehouse

Berry, Margaret E.; Taylor, Emily M.; Slate, Janet L.; Paces, James B.; Hanson, Paul R.; Brandt, Theodore R.

2018-03-21

The Weldona 7.5′ quadrangle is located on the semiarid plains of northeastern Colorado, along the South Platte River corridor where the river has incised into Upper Cretaceous Pierre Shale. The Pierre Shale is largely covered by surficial deposits that formed from alluvial, eolian, and hillslope processes operating in concert with environmental changes from the Pleistocene to the present. The South Platte River, originating high in the Colorado Rocky Mountains, has played a major role in shaping surficial geology in the map area, which is several tens of kilometers downstream from where headwater tributaries join the river. Recurrent glaciation (and deglaciation) of basin headwaters has affected river discharge and sediment supply far downstream, influencing deposition of alluvium and river incision in the Weldona quadrangle. During the Pleistocene the course of the river within the map area shifted progressively southward as it incised, and by late middle Pleistocene the river was south of its present position, cutting and filling deep paleochannels now covered by younger alluvium. The river shifted back to the north during the late Pleistocene. Kiowa and Bijou Creeks are unglaciated tributaries originating in the Colorado Piedmont east of the Front Range that also have played a major role in shaping surficial geology of the map area. Periodically during the late Pleistocene, major flood events on these tributaries deposited large volumes of sediment at their confluences, forming a broad, low-gradient fan of sidestream alluvium that could have occasionally dammed the river for short periods of time. Eolian sand deposits of the Sterling (north of river) and Fort Morgan (south of river) dune fields cover much of the quadrangle and record past episodes of sand mobilization during times of prolonged drought. With the onset of irrigation and damming during historical times, the South Platte River has changed from a broad, shallow, and sandy braided river with highly variable seasonal discharge to a much narrower, deeper river with braided-meandering transition morphology and more uniform discharge.

Depth Estimation of Submerged Aquatic Vegetation in Clear Water Streams Using Low-Altitude Optical Remote Sensing

PubMed Central

Visser, Fleur; Buis, Kerst; Verschoren, Veerle; Meire, Patrick

2015-01-01

UAVs and other low-altitude remote sensing platforms are proving very useful tools for remote sensing of river systems. Currently consumer grade cameras are still the most commonly used sensors for this purpose. In particular, progress is being made to obtain river bathymetry from the optical image data collected with such cameras, using the strong attenuation of light in water. No studies have yet applied this method to map submergence depth of aquatic vegetation, which has rather different reflectance characteristics from river bed substrate. This study therefore looked at the possibilities to use the optical image data to map submerged aquatic vegetation (SAV) depth in shallow clear water streams. We first applied the Optimal Band Ratio Analysis method (OBRA) of Legleiter et al. (2009) to a dataset of spectral signatures from three macrophyte species in a clear water stream. The results showed that for each species the ratio of certain wavelengths were strongly associated with depth. A combined assessment of all species resulted in equally strong associations, indicating that the effect of spectral variation in vegetation is subsidiary to spectral variation due to depth changes. Strongest associations (R2-values ranging from 0.67 to 0.90 for different species) were found for combinations including one band in the near infrared (NIR) region between 825 and 925 nm and one band in the visible light region. Currently data of both high spatial and spectral resolution is not commonly available to apply the OBRA results directly to image data for SAV depth mapping. Instead a novel, low-cost data acquisition method was used to obtain six-band high spatial resolution image composites using a NIR sensitive DSLR camera. A field dataset of SAV submergence depths was used to develop regression models for the mapping of submergence depth from image pixel values. Band (combinations) providing the best performing models (R2-values up to 0.77) corresponded with the OBRA findings. A 10% error was achieved under sub-optimal data collection conditions, which indicates that the method could be suitable for many SAV mapping applications. PMID:26437410

Depth Estimation of Submerged Aquatic Vegetation in Clear Water Streams Using Low-Altitude Optical Remote Sensing.

PubMed

Visser, Fleur; Buis, Kerst; Verschoren, Veerle; Meire, Patrick

2015-09-30

UAVs and other low-altitude remote sensing platforms are proving very useful tools for remote sensing of river systems. Currently consumer grade cameras are still the most commonly used sensors for this purpose. In particular, progress is being made to obtain river bathymetry from the optical image data collected with such cameras, using the strong attenuation of light in water. No studies have yet applied this method to map submergence depth of aquatic vegetation, which has rather different reflectance characteristics from river bed substrate. This study therefore looked at the possibilities to use the optical image data to map submerged aquatic vegetation (SAV) depth in shallow clear water streams. We first applied the Optimal Band Ratio Analysis method (OBRA) of Legleiter et al. (2009) to a dataset of spectral signatures from three macrophyte species in a clear water stream. The results showed that for each species the ratio of certain wavelengths were strongly associated with depth. A combined assessment of all species resulted in equally strong associations, indicating that the effect of spectral variation in vegetation is subsidiary to spectral variation due to depth changes. Strongest associations (R²-values ranging from 0.67 to 0.90 for different species) were found for combinations including one band in the near infrared (NIR) region between 825 and 925 nm and one band in the visible light region. Currently data of both high spatial and spectral resolution is not commonly available to apply the OBRA results directly to image data for SAV depth mapping. Instead a novel, low-cost data acquisition method was used to obtain six-band high spatial resolution image composites using a NIR sensitive DSLR camera. A field dataset of SAV submergence depths was used to develop regression models for the mapping of submergence depth from image pixel values. Band (combinations) providing the best performing models (R²-values up to 0.77) corresponded with the OBRA findings. A 10% error was achieved under sub-optimal data collection conditions, which indicates that the method could be suitable for many SAV mapping applications.

Use of acoustic classification of sidescan sonar data for mapping benthic habitat in the Northern Channel Islands, California

USGS Publications Warehouse

Cochrane, Guy R.; Lafferty, Kevin D.

2002-01-01

Highly reflective seafloor features imaged by sidescan sonar in nearshore waters off the Northern Channel Islands (California, USA) have been observed in subsequent submersible dives to be areas of thin sand covering bedrock. Adjacent areas of rocky seafloor, suitable as habitat for endangered species of abalone and rockfish, and encrusting organisms, cannot be differentiated from the areas of thin sand on the basis of acoustic backscatter (i.e. grey level) alone. We found second-order textural analysis of sidescan sonar data useful to differentiate the bottom types where data is not degraded by near-range distortion (caused by slant-range and ground-range corrections), and where data is not degraded by far-range signal attenuation. Hand editing based on submersible observations is necessary to completely convert the sidescan sonar image to a bottom character classification map suitable for habitat mapping.

How Long Was the Coast of Ireland? Investigating the Variation of the Fractal Dimension of Maps over Time

ERIC Educational Resources Information Center

McCartney, M.; Myers, D.; Sun, Y.

2008-01-01

The divider dimensions of a range of maps of Ireland dating from 1567 to 1893 are evaluated, and it is shown that for maps produced before 1650 the fractal dimension of the map can be correlated to its date of publication. Various classroom uses and extensions are discussed. (Contains 2 figures.)

Modeling forest site productivity using mapped geospatial attributes within a South Carolina landscape, USA

Treesearch

B.R. Parresol; D.A. Scott; S.J. Zarnoch; L.A. Edwards; J.I. Blake

2017-01-01

Spatially explicit mapping of forest productivity is important to assess many forest management alternatives. We assessed the relationship between mapped variables and site index of forests ranging from southern pine plantations to natural hardwoods on a 74,000-ha landscape in South Carolina, USA. Mapped features used in the analysis were soil association, land use...

Map Your Way to Speech Success! Employing Mind Mapping as a Speech Preparation Technique

ERIC Educational Resources Information Center

Paxman, Christina G.

2011-01-01

Mind mapping has gained considerable credibility recently in corporations such as Boeing and Nabisco, as well as in the classroom in terms of preparing for examinations and preparing for speeches. A mind map is a graphic technique for organizing an individual's thoughts and other information. It harnesses the full range of cortical skills--word,…

3D maps of the local interstellar medium: the impact of Gaia

NASA Astrophysics Data System (ADS)

Capitanio, L.; Lallement, R.; Vergely, J. L.; Elyajouri, M.; Babusiaux, C.; Ruiz-Dern, L.; Monreal-Ibero, A.; Arenou, F.; Danielski, C.

2017-12-01

Gaia parallaxes combined with colour excess and absorption measurements from large stellar surveys will allow building increasingly precise three-dimensional maps of the interstellar matter (ISM). Reciprocally, detailed maps of the ISM will allow improving photometric calibrations of Gaia and measuring more precisely the amounts of reddening. In the future, the extraction of a diffuse interstellar band (DIB) from Gaia RVS (Radial Velocity Spectrometer) spectra will allow to build a tomography of the carrier of this DIB and compare it with dust and gas distributions. Here we show several results that illustrate current progress in local ISM mapping and a first example of the stellar-interstellar synergy linked to Gaia: a) how Gaia-DR1 parallaxes already modify the ISM maps obtained by means of a full-3D inversion of a compilation of colour excess data, b) how DIB measurements and corresponding Gaia parallaxes can complement colour excess data and improve the maps, c) new hierarchical methods combining distinct surveys, d) improved maps including APOGEE colour excess estimates deduced from the recent Gaia-based photometric calibrations of Ruiz-Dern et al (this issue), e) additional inclusion of LAMOST colour excess estimates (Wang et al, 2016).

Comparison of traditional burn wound mapping with a computerized program.

PubMed

Williams, James F; King, Booker T; Aden, James K; Serio-Melvin, Maria; Chung, Kevin K; Fenrich, Craig A; Salinas, José; Renz, Evan M; Wolf, Steven E; Blackbourne, Lorne H; Cancio, Leopoldo C

2013-01-01

Accurate burn estimation affects the use of burn resuscitation formulas and treatment strategies, and thus can affect patient outcomes. The objective of this process-improvement project was to compare the accuracy of a computer-based burn mapping program, WoundFlow (WF), with the widely used hand-mapped Lund-Browder (LB) diagram. Manikins with various burn representations (from 1% to more than 60% TBSA) were used for comparison of the WF system and LB diagrams. Burns were depicted on the manikins using red vinyl adhesive. Healthcare providers responsible for mapping of burn patients were asked to perform burn mapping of the manikins. Providers were randomized to either an LB or a WF group. Differences in the total map area between groups were analyzed. Also, direct measurements of the burn representations were taken and compared with LB and WF results. The results of 100 samples, compared using Bland-Altman analysis, showed no difference between the two methods. WF was as accurate as LB mapping for all burn surface areas. WF may be additionally beneficial in that it can track daily progress until complete wound closure, and can automatically calculate burn size, thus decreasing the chances of mathematical errors.

DNA Probe Pooling for Rapid Delineation of Chromosomal Breakpoints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Chun-Mei; Kwan, Johnson; Baumgartner, Adolf

2009-01-30

Structural chromosome aberrations are hallmarks of many human genetic diseases. The precise mapping of translocation breakpoints in tumors is important for identification of genes with altered levels of expression, prediction of tumor progression, therapy response, or length of disease-free survival as well as the preparation of probes for detection of tumor cells in peripheral blood. Similarly, in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for carriers of balanced, reciprocal translocations benefit from accurate breakpoint maps in the preparation of patient-specific DNA probes followed by a selection of normal or balanced oocytes or embryos. We expedited the process of breakpointmore » mapping and preparation of case-specific probes by utilizing physically mapped bacterial artificial chromosome (BAC) clones. Historically, breakpoint mapping is based on the definition of the smallest interval between proximal and distal probes. Thus, many of the DNA probes prepared for multi-clone and multi-color mapping experiments do not generate additional information. Our pooling protocol described here with examples from thyroid cancer research and PGD accelerates the delineation of translocation breakpoints without sacrificing resolution. The turnaround time from clone selection to mapping results using tumor or IVF patient samples can be as short as three to four days.« less

Spot-mapping underestimates song-territory size and use of mature forest by breeding golden-winged warblers in Minnesota, USA

USGS Publications Warehouse

Streby, Henry M.; Loegering, John P.; Andersen, David E.

2012-01-01

Studies of songbird breeding habitat often compare habitat characteristics of used and unused areas. Although there is usually meticulous effort to precisely and consistently measure habitat characteristics, accuracy of methods for estimating which areas are used versus which are unused by birds remains generally untested. To examine accuracy of spot-mapping to identify singing territories of golden-winged warblers (Vermivora chrysoptera), which are considered an early successional forest specialists, we used spot-mapping and radiotelemetry to record song perches and delineate song territories for breeding male golden-winged warblers in northwestern Minnesota, USA. We also used radiotelemetry to record locations (song and nonsong perches) of a subsample (n = 12) of males throughout the day to delineate home ranges. We found that telemetry-based estimates of song territories were 3 times larger and included more mature forest than those estimated from spot-mapping. In addition, home ranges estimated using radiotelemetry included more mature forest than spot-mapping- and telemetry-based song territories, with 75% of afternoon perches located in mature forest. Our results suggest that mature forest comprises a larger component of golden-winged warbler song territories and home ranges than is indicated based on spot-mapping in Minnesota. Because it appears that standard observational methods can underestimate territory size and misidentify cover-type associations for golden-winged warblers, we caution that management and conservation plans may be misinformed, and that similar studies are needed for golden-winged warblers across their range and for other songbird species.

Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma.

PubMed

Hao, Yoshiteru; Numata, Kazushi; Ishii, Tomohiro; Fukuda, Hiroyuki; Maeda, Shin; Nakano, Masayuki; Tanaka, Katsuaki

2017-05-07

To evaluate whether pathologically early hepatocellular carcinoma (HCC) exhibited local tumor progression after radiofrequency ablation (RFA) less often than typical HCC. Fifty pathologically early HCCs [tumor diameter (mm): mean, 15.8; range, 10-23; follow-up days after RFA: median, 1213; range, 216-2137] and 187 typical HCCs [tumor diameter (mm): mean, 15.6; range, 6-30; follow-up days after RFA: median, 1116; range, 190-2328] were enrolled in this retrospective study. The presence of stromal invasion (namely, tumor cell invasion into the intratumoral portal tracts) was considered to be the most important pathologic finding for the diagnosis of early HCCs. Typical HCC was defined as the presence of a hyper-vascular lesion accompanied by delayed washout using contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. Follow-up examinations were performed at 3-mo intervals to monitor for signs of local tumor progression. The local tumor progression rates of pathologically early HCCs and typical HCCs were then determined using the Kaplan-Meier method. During the follow-up period for the 50 pathologically early HCCs, 49 (98%) of the nodules did not exhibit local tumor progression. However, 1 nodule (2%) was associated with a local tumor progression found 636 d after RFA. For the 187 typical HCCs, 46 (24.6%) of the nodules exhibited local recurrence after RFA. The follow-up period until the local tumor progression of typical HCC was a median of 605 d, ranging from 181 to 1741 d. Among the cases with typical HCCs, local tumor progression had occurred in 7.0% (7/187), 16.0% (30/187), 21.9% (41/187) and 24.6% (46/187) of the cases at 1, 2, 3 and 4 years, respectively. Pathologically early HCC was statistically associated with a lower rate of local tumor progression, compared with typical HCC, when evaluated using a log-rank test ( P = 0.002). The rate of local tumor progression for pathologically early HCCs after RFA was significantly lower than that for typical HCCs.

Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma

PubMed Central

Hao, Yoshiteru; Numata, Kazushi; Ishii, Tomohiro; Fukuda, Hiroyuki; Maeda, Shin; Nakano, Masayuki; Tanaka, Katsuaki

2017-01-01

AIM To evaluate whether pathologically early hepatocellular carcinoma (HCC) exhibited local tumor progression after radiofrequency ablation (RFA) less often than typical HCC. METHODS Fifty pathologically early HCCs [tumor diameter (mm): mean, 15.8; range, 10-23; follow-up days after RFA: median, 1213; range, 216-2137] and 187 typical HCCs [tumor diameter (mm): mean, 15.6; range, 6-30; follow-up days after RFA: median, 1116; range, 190-2328] were enrolled in this retrospective study. The presence of stromal invasion (namely, tumor cell invasion into the intratumoral portal tracts) was considered to be the most important pathologic finding for the diagnosis of early HCCs. Typical HCC was defined as the presence of a hyper-vascular lesion accompanied by delayed washout using contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. Follow-up examinations were performed at 3-mo intervals to monitor for signs of local tumor progression. The local tumor progression rates of pathologically early HCCs and typical HCCs were then determined using the Kaplan-Meier method. RESULTS During the follow-up period for the 50 pathologically early HCCs, 49 (98%) of the nodules did not exhibit local tumor progression. However, 1 nodule (2%) was associated with a local tumor progression found 636 d after RFA. For the 187 typical HCCs, 46 (24.6%) of the nodules exhibited local recurrence after RFA. The follow-up period until the local tumor progression of typical HCC was a median of 605 d, ranging from 181 to 1741 d. Among the cases with typical HCCs, local tumor progression had occurred in 7.0% (7/187), 16.0% (30/187), 21.9% (41/187) and 24.6% (46/187) of the cases at 1, 2, 3 and 4 years, respectively. Pathologically early HCC was statistically associated with a lower rate of local tumor progression, compared with typical HCC, when evaluated using a log-rank test (P = 0.002). CONCLUSION The rate of local tumor progression for pathologically early HCCs after RFA was significantly lower than that for typical HCCs. PMID:28533668

The timing and extent of Quaternary glaciation of Stok, northern Zanskar Range, Transhimalaya, of northern India

NASA Astrophysics Data System (ADS)

Orr, Elizabeth N.; Owen, Lewis A.; Murari, Madhav K.; Saha, Sourav; Caffee, Marc W.

2017-05-01

The glacial history of three tributary valleys (Namlung, Gopal Kangri and Stok Kangri) of the Stok valley, south of the Indus valley in the northern sector of the Zanskar Range, northern India is characterized using geomorphic mapping and cosmogenic 10Be surface exposure dating. The new glacial chronostratigraphy for the Stok valley is the first for the northern Zanskar Range and provides insights into the spatial variability of glaciation in the Himalayan-Tibetan orogen. This framework facilitates the understanding of the nature and the timing of landscape evolution and paleoenvironmental change in the Himalayan-Tibetan orogen. At least four glacial stages are evident within each of the tributary valleys of Gopal Kangri (MG1-MG4, youngest to oldest) and Stok Kangri (MS1-MS4) that feed into the Stok valley. With the exception of the MG4 glacial advance ( 124 ka) in Gopal Kangri, the Stok valley has preserved evidence of glaciations from 50 ka to the present. Equilibrium-line altitudes and glacier reconstructions for the Stok valley and its tributaries demonstrate that glaciations have become progressively less extensive through time. Former glacier extents of the Stok region are comparable in length with glacial advances during the last glacial cycle in eastern Zanskar and in the southern Ladakh Range to the south and north of the Indus valley, respectively. Landscape evolution in the study area has occurred across numerous glacial-interglacial cycles by a combination of glacial and fluvial processes and is similar to that of the Ladakh Range.

ILRS: Current Status and Future Challenges

NASA Astrophysics Data System (ADS)

Pearlman, M. R.; Bianco, G.; Merkowitz, S.; Noll, C. E.; Pavlis, E. C.; Shargorodsky, V.; Zhongping, Z.

2016-12-01

The International Laser Ranging Service (ILRS) is expanding its ground tracking capability with new stations and upgrades to current stations. Our Russian colleagues have installed new stations in Brasilia and South Africa, and have several other sites in process or in planning. The NASA Space Geodesy Program is preparing equipment for U.S. sites (McDonald and Haleakala) and with the Norwegian National Mapping Agency in Ny Ålesund; further deployments are planned. Upgrades continue at sites in China, and new sites are underway or planned in Europe and India. Stations are moving to higher repetition rates and more efficient detection to enhance satellite interleaving capability; some stations have already implemented automated processes that could lead to around-the-clock operation to increase temporal coverage and to make more efficient use of personnel. The ILRS roster of supported satellites continues to grow with the addition of the LARES satellite to augment tracking for the improvement of the ITRF. New GNSS constellations and geosynchronous satellites now bring the total roster to over 80 satellites - so much so, that new tracking strategies and time and location multiplexing are under consideration. There continues to be strong interest in Lunar Ranging. New applications of one-way and two-way laser ranging include ps-accurate time transfer, laser transponders for interplanetary ranging, and tracking of space debris. New laser ranging data products are being developed, including satellite orbit products, satellite orientation, gravity field products, and products to characterize the quality of data and station performance. This talk will give a brief summary of recent progress, current challenges and a view of the path ahead.

Forest and Range Inventory and Mapping

NASA Technical Reports Server (NTRS)

Aldrich, R. C.

1971-01-01

The state of the art in remote sensing for forest and range inventories and mapping has been discussed. There remains a long way to go before some of these techniques can be used on an operational basis. By the time that the Earth Resources Technology Satellite and Skylab space missions are flown, it should be possible to tell what kind and what quality of information can be extracted from remote sensors and how it can be used for surveys of forest and range resources.

Fast progressive lower motor neuron disease is an ALS variant: A two-centre tract of interest-based MRI data analysis.

PubMed

Müller, Hans-Peter; Agosta, Federica; Riva, Nilo; Spinelli, Edoardo G; Comi, Giancarlo; Ludolph, Albert C; Filippi, Massimo; Kassubek, Jan

2018-01-01

The criteria for assessing upper motor neuron pathology in pure lower motor neuron disease (LMND) still remain a major issue of debate with respect to the clinical classification as an amyotrophic lateral sclerosis (ALS) variant. The study was designed to investigate white matter damage by a hypothesis-guided tract-of-interest-based approach in patients with LMND compared with healthy controls and ´classical´ ALS patients in order to identify in vivo brain structural changes according to the neuropathologically defined ALS affectation pattern. Data were pooled from two previous studies at two different study sites (Ulm, Germany and Milano, Italy). DTI-based white matter integrity mapping was performed by voxelwise statistical comparison and by a tractwise analysis of fractional anisotropy (FA) maps according to the ALS-staging pattern for 65 LMND patients (clinically differentiated in fast and slow progressors) vs. 92 matched controls and 101 ALS patients with a 'classical' phenotype to identify white matter structural alterations. The analysis of white matter structural connectivity by regional FA reductions demonstrated the characteristic alteration patterns along the CST and also in frontal and prefrontal brain areas in LMND patients compared to controls and ALS. Fast progressing LMND showed substantial involvement, like in ALS, while slow progressors showed less severe alterations. In the tract-specific analysis according to the ALS-staging pattern, fast progressing LMND showed significant alterations of ALS-related tract systems as compared to slow progressors and controls. This study showed an affectation pattern for corticoefferent fibers in LMND with fast disease progression as defined for ALS, that way confirming the hypothesis that fast progressing LMND is a phenotypical variant of ALS.

Defining acute aortic syndrome after trauma: Are Abbreviated Injury Scale codes a useful surrogate descriptor?

PubMed

Leach, R; McNally, Donal; Bashir, Mohamad; Sastry, Priya; Cuerden, Richard; Richens, David; Field, Mark

2012-10-01

The severity and location of injuries resulting from vehicular collisions are normally recorded in Abbreviated Injury Scale (AIS) code; we propose a system to link AIS code to a description of acute aortic syndrome (AAS), thus allowing the hypothesis that aortic injury is progressive with collision kinematics to be tested. Standard AIS codes were matched with a clinical description of AAS. A total of 199 collisions that resulted in aortic injury were extracted from a national automotive collision database and the outcomes mapped onto AAS descriptions. The severity of aortic injury (AIS severity score) and stage of AAS progression were compared with collision kinematics and occupant demographics. Post hoc power analyses were used to estimate maximum effect size. The general demographic distribution of the sample represented that of the UK population in regard to sex and age. No significant relationship was observed between estimated test speed, collision direction, occupant location or seat belt use and clinical progression of aortic injury (once initiated). Power analysis confirmed that a suitable sample size was used to observe a medium effect in most of the cases. Similarly, no association was observed between injury severity and collision kinematics. There is sufficient information on AIS severity and location codes to map onto the clinical AAS spectrum. It was not possible, with this data set, to consider the influence of collision kinematics on aortic injury initiation. However, it was demonstrated that after initiation, further progression along the AAS pathway was not influenced by collision kinematics. This might be because the injury is not progressive, because the vehicle kinematics studied do not fully represent the kinematics of the occupants, or because an unknown factor, such as stage of cardiac cycle, dominates. Epidemiologic/prognostic study, level IV.

Hydrothermal alteration maps of the central and southern Basin and Range province of the United States compiled from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data

USGS Publications Warehouse

Mars, John L.

2013-01-01

Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data and Interactive Data Language (IDL) logical operator algorithms were used to map hydrothermally altered rocks in the central and southern parts of the Basin and Range province of the United States. The hydrothermally altered rocks mapped in this study include (1) hydrothermal silica-rich rocks (hydrous quartz, chalcedony, opal, and amorphous silica), (2) propylitic rocks (calcite-dolomite and epidote-chlorite mapped as separate mineral groups), (3) argillic rocks (alunite-pyrophyllite-kaolinite), and (4) phyllic rocks (sericite-muscovite). A series of hydrothermal alteration maps, which identify the potential locations of hydrothermal silica-rich, propylitic, argillic, and phyllic rocks on Landsat Thematic Mapper (TM) band 7 orthorectified images, and geographic information systems shape files of hydrothermal alteration units are provided in this study.

Integrating geophysical data for mapping the contamination of industrial sites by polycyclic aromatic hydrocarbons: A geostatistical approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colin, P.; Nicoletis, S.; Froidevaux, R.

1996-12-31

A case study is presented of building a map showing the probability that the concentration in polycyclic aromatic hydrocarbon (PAH) exceeds a critical threshold. This assessment is based on existing PAH sample data (direct information) and on an electrical resistivity survey (indirect information). Simulated annealing is used to build a model of the range of possible values for PAH concentrations and of the bivariate relationship between PAH concentrations and electrical resistivity. The geostatistical technique of simple indicator kriging is then used, together with the probabilistic model, to infer, at each node of a grid, the range of possible values whichmore » the PAH concentration can take. The risk map is then extracted for this characterization of the local uncertainty. The difference between this risk map and a traditional iso-concentration map is then discussed in terms of decision-making.« less

Molecularly tagged genes and quantitative trait loci in cucumber

USDA-ARS?s Scientific Manuscript database

Since the release of the cucumber draft genome, significant progress has been made in molecular mapping, tagging or cloning of horticulturally important genes and quantitative trait loci (QTLs) in cucumber, which provides the foundation for practicing marker-assisted selection in cucumber breeding. ...

Australian radio observations of SN1987A - A progress report

NASA Technical Reports Server (NTRS)

Reynolds, John E.; Jauncey, David L.; Preston, Robert A.; Mutel, Robert L.; Livermore, R. W.

1987-01-01

Regular monitoring of SN 1987A in the radio spectrum is being conducted at a number of Australian observatories. Although no emission is detectable at present, a VLBI network has been established to map a possible major outburst at high resolution.

Project UCARE : Uniform Commuter Assistance Reporting and Evaluation for transportation demand management programs.

DOT National Transportation Integrated Search

2013-09-01

Moving Ahead for Progress in the 21st Century Act (MAP-21) places emphasis upon results and better management of programs for effective and efficient service delivery. With an increased focus on measuring performance, the transportation demand manage...

EFFECTS OF SENSOR RESOLUTION ON MAPPING IN-STREAM HABITATS. (R827638)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

THE CONCORDANCE MAP AS A TOOL FOR LANDSCAPE ANALYSIS. (R824766)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Bus safety study : a report to Congress.

DOT National Transportation Integrated Search

2013-11-01

Section 20021(b) of the Moving Ahead for Progress for the 21st Century (MAP-21) legislation requires the Secretary of Transportation : to submit a report of the results of a Bus Safety Study to the Committee on Banking, Housing, and Urban Affai...

Development of Performance Measurement for Freight Transportation : Research Project Capsule

DOT National Transportation Integrated Search

2012-10-01

The new Moving Ahead for : Progress in the 21st Century : Act (MAP-21), passed by the : U.S Senate and pending at : the U.S. House of Representatives, requests the national freight network to : incorporate concepts of performance and accountabilit...

Recent advances in parametric neuroreceptor mapping with dynamic PET: basic concepts and graphical analyses.

PubMed

Seo, Seongho; Kim, Su Jin; Lee, Dong Soo; Lee, Jae Sung

2014-10-01

Tracer kinetic modeling in dynamic positron emission tomography (PET) has been widely used to investigate the characteristic distribution patterns or dysfunctions of neuroreceptors in brain diseases. Its practical goal has progressed from regional data quantification to parametric mapping that produces images of kinetic-model parameters by fully exploiting the spatiotemporal information in dynamic PET data. Graphical analysis (GA) is a major parametric mapping technique that is independent on any compartmental model configuration, robust to noise, and computationally efficient. In this paper, we provide an overview of recent advances in the parametric mapping of neuroreceptor binding based on GA methods. The associated basic concepts in tracer kinetic modeling are presented, including commonly-used compartment models and major parameters of interest. Technical details of GA approaches for reversible and irreversible radioligands are described, considering both plasma input and reference tissue input models. Their statistical properties are discussed in view of parametric imaging.

Synoptic maps constructed from brightness observations of Thomson scattering by heliospheric electrons

NASA Technical Reports Server (NTRS)

Hick, P.; Jackson, B.; Schwenn, R.

1991-01-01

Observations of the Thomson scattering brightness by electrons in the inner heliosphere provide a means of probing the heliospheric electron distributions. An extensive data base of Thomson scattering observations, stretching over many years, is available from the zodiacal light photometers on board the two Helios spacecraft. A survey of these data is in progress, presenting these scattering intensities in the form of synoptic maps for successive Carrington rotations. The Thomson scattering maps reflect conditions at typically several tenths of an astronomical unit from the sun. Some representative examples from the survey in comparison with other solar/heliospheric data, such as in situ observations of the Helios plasma experiment and synoptic maps constructed from magnetic field, H alpha and K-coronameter data are presented. The comparison will provide some information about the extension of solar surface features into the inner heliosphere.

Graphic symbols as "the mind on paper": links between children's interpretive theory of mind and symbol understanding.

PubMed

Myers, Lauren J; Liben, Lynn S

2012-01-01

Children gradually develop interpretive theory of mind (iToM)-the understanding that different people may interpret identical events or stimuli differently. The present study tested whether more advanced iToM underlies children's recognition that map symbols' meanings must be communicated to others when symbols are iconic (resemble their referents). Children (6-9 years; N = 80) made maps using either iconic or abstract symbols. After accounting for age, intelligence, vocabulary, and memory, iToM predicted children's success in communicating symbols' meaning to a naïve map-user when mapping tasks involved iconic (but not abstract) symbols. Findings suggest children's growing appreciation of alternative representations and of the intentional assignment of meaning, and support the contention that ToM progresses beyond mastery of false belief. © 2011 The Authors. Child Development © 2011 Society for Research in Child Development, Inc.

Digital images in the map revision process

NASA Astrophysics Data System (ADS)

Newby, P. R. T.

Progress towards the adoption of digital (or softcopy) photogrammetric techniques for database and map revision is reviewed. Particular attention is given to the Ordnance Survey of Great Britain, the author's former employer, where digital processes are under investigation but have not yet been introduced for routine production. Developments which may lead to increasing automation of database update processes appear promising, but because of the cost and practical problems associated with managing as well as updating large digital databases, caution is advised when considering the transition to softcopy photogrammetry for revision tasks.

Investigation of Antarctic crust and upper mantle using MAGSAT and other geophysical data

NASA Technical Reports Server (NTRS)

Bentley, C. R. (Principal Investigator)

1981-01-01

Progress in processing and analysis of Investigator B MAGSAT data is reported. Data processing tasks required prior to data analysis, including translation and reformatting of tapes and development of computer routines, were performed. A scalar anomaly map of Antarctica is near completion. Data analysis included a qualitative correlation of NASA's 4/81 scalar map of Antarctica with other geopotential data and correlation of POGO and continental scale gravity data with MAGSAT data. A magnetic high was found to exist over the Ross Embayment.

Bioanalysis: its past, present, and some future.

PubMed

Righetti, Pier Giorgio

2004-07-01

An overview of about 100 years of bioanalysis is here disastrously attempted. The beginning of rigorous analytical systems can perhaps be traced back to the building and testing of the analytical ultracentrifuge by Svedberg and the apparatus for moving-boundary electrophoresis of Tiselius, both systems relying on expensive and hard to operate machines. In the sixties, Porath discovered porous beads for the determination of relative molecular mass (Mr) of proteins, based on the principle of molecular sieving. Concomitantly, Svensson and his pupil Vesterberg described a revolutionary principle for fractionating proteins in a nonisocratic environment, based on generation of stable pH gradients in an electric field, a technique that went down to history as isoelectric focusing (IEF). Polyacrylamide gel electrophoresis (PAGE), with the brilliant idea of discontinuous buffers, was brought to the limelight and in 1967, sodium dodecyl sulfate (SDS)-PAGE was described, permitting easy assessment of protein purity and reasonable measurements of Mr values of denatured polypeptide chains. By the mid seventies, another explosive concept was realized: orthogonal combination of two unrelated techniques, based on surface charge and mass fractionation, namely, two-dimensional (2-D) PAGE already in the very first papers by O'Farrell elaborated to its utmost sophistication. The eighties saw the systematic growth of 2-D PAGE, accompanied by systematic efforts to develop instrumentation for large-scale production of 2-D maps and computer evaluation for 2-D map analysis, based on the sophisticated algorithms adopted by astronomers for mapping stars in the sky. Another fundamental innovation in the field of IEF was the discovery of immobilized pH gradients (IPGs) that brought the much needed reproducibility in 2-D maps while allowing exquisite resolution in very narrow pH ranges. The nineties were definitely the decade of capillary zone electrophoresis, with the concomitant concept of automation and miniaturization in electrokinetic methodologies. Also 2-D map analysis witnessed a big revival, thanks to the adoption of IPGs for the first dimension. The enormous progress of mass spectrometry resulted in first reports on the analysis of macromolecules and the building of data bases on gene and protein banks. The third millennium is, perhaps, exasperating the concept of miniaturization at all costs, while not disdaining increasingly larger maps for 2-D analysis of complex protein mixtures.

Geologic Map of the North Cascade Range, Washington

USGS Publications Warehouse

Haugerud, Ralph A.; Tabor, Rowland W.

2009-01-01

The North Cascade Range, commonly referred to as the North Cascades, is the northern part of the Cascade Range that stretches from northern California into British Columbia, where it merges with the Coast Mountains of British Columbia at the Fraser River. The North Cascades are generally characterized by exposure of plutonic and metamorphic rocks in contrast to the volcanic terrain to the south. The rocks of the North Cascades are more resistant to erosion, display greater relief, and show evidence of more pronounced uplift and recent glaciation. Although the total length of the North Cascade Range, extending north from Snoqualmie Pass in Washington, is about 200 mi (320 km), this compilation map at 1:200,000 scale covers only that part (~150 mi) in the United States. The compilation map is derived mostly from eight 1:100,000-scale quadrangle maps that include all of the North Cascade Range in Washington and a bit of the mostly volcanic part of the Cascade Range to the south (fig. 1, sheet 2). Overall, the area represented by this compilation is about 12,740 mi2 (33,000 km2). The superb alpine scenery of the North Cascade Range and its proximity to major population centers has led to designation of much of the area for recreational use or wilderness preservation. A major part of the map area is in North Cascade National Park. Other restricted use areas are the Alpine Lakes, Boulder River, Clearwater, Glacier Peak, Henry M. Jackson, Lake Chelan-Sawtooth, Mount Baker, Noisy-Diobsud, Norse Peak, and Pasayten Wildernesses and the Mount Baker, Lake Chelan, and Ross Lake National Recreation Areas. The valleys traversed by Washington State Highway 20 east of Ross Lake are preserved as North Cascades Scenic Highway. The map area is traversed by three major highways: U.S. Interstate 90, crossing Snoqualmie Pass; Washington State Highway 2, crossing Stevens Pass; and Washington State Highway 20, crossing Washington Pass. Major secondary roads, as well as a network of U.S. Forest Service roads and a few private roads mainly used for logging, are restricted mostly to the flanks of the range. Although much of the mountainous core is inaccessible to automobiles, numerous trails serve the foot or horse traveler.

EMDataBank unified data resource for 3DEM.

PubMed

Lawson, Catherine L; Patwardhan, Ardan; Baker, Matthew L; Hryc, Corey; Garcia, Eduardo Sanz; Hudson, Brian P; Lagerstedt, Ingvar; Ludtke, Steven J; Pintilie, Grigore; Sala, Raul; Westbrook, John D; Berman, Helen M; Kleywegt, Gerard J; Chiu, Wah

2016-01-04

Three-dimensional Electron Microscopy (3DEM) has become a key experimental method in structural biology for a broad spectrum of biological specimens from molecules to cells. The EMDataBank project provides a unified portal for deposition, retrieval and analysis of 3DEM density maps, atomic models and associated metadata (emdatabank.org). We provide here an overview of the rapidly growing 3DEM structural data archives, which include maps in EM Data Bank and map-derived models in the Protein Data Bank. In addition, we describe progress and approaches toward development of validation protocols and methods, working with the scientific community, in order to create a validation pipeline for 3DEM data. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Mapping and predicting sinkholes by integration of remote sensing and spectroscopy methods

NASA Astrophysics Data System (ADS)

Goldshleger, N.; Basson, U.; Azaria, I.

2013-08-01

The Dead Sea coastal area is exposed to the destructive process of sinkhole collapse. The increase in sinkhole activity in the last two decades has been substantial, resulting from the continuous decrease in the Dead Sea's level, with more than 1,000 sinkholes developing as a result of upper layer collapse. Large sinkholes can reach 25 m in diameter. They are concentrated mainly in clusters in several dozens of sites with different characteristics. In this research, methods for mapping, monitoring and predicting sinkholes were developed using active and passive remote-sensing methods: field spectrometer, geophysical ground penetration radar (GPR) and a frequency domain electromagnetic instrument (FDEM). The research was conducted in three stages: 1) literature review and data collection; 2) mapping regions abundant with sinkholes in various stages and regions vulnerable to sinkholes; 3) analyzing the data and translating it into cognitive and accessible scientific information. Field spectrometry enabled a comparison between the spectral signatures of soil samples collected near active or progressing sinkholes, and those collected in regions with no visual sign of sinkhole occurrence. FDEM and GPR investigations showed that electrical conductivity and soil moisture are higher in regions affected by sinkholes. Measurements taken at different time points over several seasons allowed monitoring the progress of an 'embryonic' sinkhole.

Brain maps, great and small: lessons from comparative studies of primate visual cortical organization

PubMed Central

Rosa, Marcello G.P; Tweedale, Rowan

2005-01-01

In this paper, we review evidence from comparative studies of primate cortical organization, highlighting recent findings and hypotheses that may help us to understand the rules governing evolutionary changes of the cortical map and the process of formation of areas during development. We argue that clear unequivocal views of cortical areas and their homologies are more likely to emerge for ‘core’ fields, including the primary sensory areas, which are specified early in development by precise molecular identification steps. In primates, the middle temporal area is probably one of these primordial cortical fields. Areas that form at progressively later stages of development correspond to progressively more recent evolutionary events, their development being less firmly anchored in molecular specification. The certainty with which areal boundaries can be delimited, and likely homologies can be assigned, becomes increasingly blurred in parallel with this evolutionary/developmental sequence. For example, while current concepts for the definition of cortical areas have been vindicated in allowing a clarification of the organization of the New World monkey ‘third tier’ visual cortex (the third and dorsomedial areas, V3 and DM), our analyses suggest that more flexible mapping criteria may be needed to unravel the organization of higher-order visual association and polysensory areas. PMID:15937007

Soil and ecological sites of the Santa Rita Experimental Range

Treesearch

Donald J. Breckenfeld; Daniel Robinett

2003-01-01

A soil survey and rangeland resource inventory of the Santa Rita Experimental Range (SRER) was conducted by staff from the Tucson office of the Natural Resources Conservation Service (NRCS) during April and May of 1997. Thirty-two soils series and taxadjuncts were mapped on the SRER and delineated in 24 different mapping units. These soils all occur in an Aridic and...

Use of LANDSAT imagery for wildlife habitat mapping in northeast and eastcentral Alaska. [winter and summer moose range

NASA Technical Reports Server (NTRS)

Lent, P. C. (Principal Investigator)

1976-01-01

The author has identified the following significant results. Winter and summer moose range maps of three selected areas were produced (1:63,360 scale). The analytic approach is very similar to modified clustering. Preliminary results indicate that this method is not only more accurate but considerably less expensive than supervised classification techniques.

Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry.

PubMed

Gogtay, Nitin; Lu, Allen; Leow, Alex D; Klunder, Andrea D; Lee, Agatha D; Chavez, Alex; Greenstein, Deanna; Giedd, Jay N; Toga, Arthur W; Rapoport, Judith L; Thompson, Paul M

2008-10-14

Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white matter (WM) growth abnormalities in COS throughout the brain. Using high-dimensional elastic image registration, we compared 3D maps of local WM growth rates in COS patients and healthy children over a 5-year period, based on analyzing longitudinal brain MRIs from 12 COS patients and 12 healthy controls matched for age, gender, and scan interval. COS patients showed up to 2.2% slower growth rates per year than healthy controls in WM (P = 0.02, all P values corrected). The greatest differences were in the right hemisphere (P = 0.006). This asymmetry was attributable to a right slower than left hemisphere growth rate mapped in COS patients (P = 0.037) but not in healthy controls. WM growth rates reached 2.6% per year in healthy controls (P = 0.0002). COS patients showed only a 1.3% per year trend for growth in the left hemisphere (P = 0.066). In COS, WM growth rates were associated with improvement in the Children's Global Assessment Scale (R = 0.64, P = 0.029). Growth rates were reduced throughout the brain in COS, but this process appeared to progress in a front-to-back (frontal-parietal) fashion, and this effect was not attributable to lower IQ. Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth.

A reference linkage map for Eucalyptus

PubMed Central

2012-01-01

Background Genetic linkage maps are invaluable resources in plant research. They provide a key tool for many genetic applications including: mapping quantitative trait loci (QTL); comparative mapping; identifying unlinked (i.e. independent) DNA markers for fingerprinting, population genetics and phylogenetics; assisting genome sequence assembly; relating physical and recombination distances along the genome and map-based cloning of genes. Eucalypts are the dominant tree species in most Australian ecosystems and of economic importance globally as plantation trees. The genome sequence of E. grandis has recently been released providing unprecedented opportunities for genetic and genomic research in the genus. A robust reference linkage map containing sequence-based molecular markers is needed to capitalise on this resource. Several high density linkage maps have recently been constructed for the main commercial forestry species in the genus (E. grandis, E. urophylla and E. globulus) using sequenced Diversity Arrays Technology (DArT) and microsatellite markers. To provide a single reference linkage map for eucalypts a composite map was produced through the integration of data from seven independent mapping experiments (1950 individuals) using a marker-merging method. Results The composite map totalled 1107 cM and contained 4101 markers; comprising 3880 DArT, 213 microsatellite and eight candidate genes. Eighty-one DArT markers were mapped to two or more linkage groups, resulting in the 4101 markers being mapped to 4191 map positions. Approximately 13% of DArT markers mapped to identical map positions, thus the composite map contained 3634 unique loci at an average interval of 0.31 cM. Conclusion The composite map represents the most saturated linkage map yet produced in Eucalyptus. As the majority of DArT markers contained on the map have been sequenced, the map provides a direct link to the E. grandis genome sequence and will serve as an important reference for progressing eucalypt research. PMID:22702473

Global Map of Pluto

NASA Image and Video Library

2015-07-27

The science team of NASA's New Horizons mission has produced an updated global map of the dwarf planet Pluto. The map includes all resolved images of the surface acquired between July 7-14, 2015, at pixel resolutions ranging from 40 kilometers (24 miles) on the Charon-facing hemisphere (left and right sides of the map) to 400 meters (1,250 feet) on the anti-Charon facing hemisphere (map center). Many additional images are expected in fall of 2015 and these will be used to complete the global map. http://photojournal.jpl.nasa.gov/catalog/PIA19858

Maps of the United States

USGS Publications Warehouse

,

2005-01-01

The U.S. Geological Survey (USGS) sells a variety of maps of the United States. Who needs these maps? Students, land planners, politicians, teachers, marketing specialists, delivery companies, authors and illustrators, attorneys, railroad enthusiasts, travelers, Government agencies, military recruiters, newspapers, map collectors, truckers, boaters, hikers, sales representatives, communication specialists. Everybody. Users of these maps range from a corporation planning a regional expansion or a national marketing campaign, to a person who wants a decoration to hang on the wall. If you are not sure which map best meets your needs, call the Earth Science Information Center for assistance.

Laparoscopic Sentinel Node Mapping in Endometrial Cancer After Hysteroscopic Injection of Indocyanine Green.

PubMed

Martinelli, Fabio; Ditto, Antonino; Bogani, Giorgio; Signorelli, Mauro; Chiappa, Valentina; Lorusso, Domenica; Haeusler, Edward; Raspagliesi, Francesco

2017-01-01

To report the detection rate (DR) of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients after hysteroscopic injection of indocyanine green (ICG) and laparoscopic near-infrared (L-NIR) fluorescence mapping. Prospectively collected data (Canadian Task Force classification II-2). Gynecologic oncology referral center. Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, SLN mapping. The mapping technique consisted in an intraoperative hysteroscopic peritumoral injection of 5 mg ICG followed by L-NIR fluorescence mapping. Evaluations of the SLN DR and sites of mapping were performed. A total of 57 procedures was performed. Patient mean age was 60 years (range, 28-80) and mean body mass index was 28.2 kg/m 2 (range, 19-43). At least 1 SLN was detected in 89.5% of the whole population (51/57). After the first 16 cases, L-NIR camera technical improvement led to a 95% DR (39/41). The mean number of harvested SLNs was 4.1 (range. 1-8), and in 47% of cases SLNs mapped to aortic nodes (24/51). Bilateral pelvic mapping was found in 74.5% of cases (38/51). Three patients had SLN metastases: 1 in the pelvic area only, 1 both in the pelvic and aortic area, and 1 presented with 2 metastatic aortic SLNs with negative pelvic SLNs. Overall, 2 of 3 node-positive patients (67%) had aortic SLN involvement. No adverse events were reported. Laparoscopic SLN mapping after the hysteroscopic injection of ICG has comparable DRs with both radioactive tracer series and ICG series with cervical injection, overcoming the need for radioactive substances. Hysteroscopic injection leads to a higher mapping in the aortic area compared with cervical injection. Further investigation is warranted on this topic. Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

IEMIS (Integrated Emergency Management Information System) Floodplain Mapping Based on a Lidar Derived Data Set.

DTIC Science & Technology

1988-02-05

0-A193 971 IEMIS (INTEGRATED EMERGENCY MANAGEMENT INFORMATION SYSTEM ) FLOODPLRIN MAP.. (U) ARMY ENGINEER WATERWAYS EXPERIMENT STATION VICKSBURG HS J...illustrate the application of the automated mapping capabilities of the Integrated Emergency Management Information System (IEMIS) to FISs. Unclassified...mapping capabilities of the Integrated Emergency Management Information System (IEMIS) to FISs. II. BACKGROUND The concept of mounting laser ranging

Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review.

PubMed

Deribe, Kebede; Brooker, Simon J; Pullan, Rachel L; Hailu, Asrat; Enquselassie, Fikre; Reithinger, Richard; Newport, Melanie; Davey, Gail

2013-01-01

An up-to-date and reliable map of podoconiosis is needed to design geographically targeted and cost-effective intervention in Ethiopia. Identifying the ecological correlates of the distribution of podoconiosis is the first step for distribution and risk maps. The objective of this study was to investigate the spatial distribution and ecological correlates of podoconiosis using historical and contemporary survey data. Data on the observed prevalence of podoconiosis were abstracted from published and unpublished literature into a standardized database, according to strict inclusion and exclusion criteria. In total, 10 studies conducted between 1969 and 2012 were included, and data were available for 401,674 individuals older than 15 years of age from 229 locations. A range of high resolution environmental factors were investigated to determine their association with podoconiosis prevalence, using logistic regression. The prevalence of podoconiosis in Ethiopia was estimated at 3.4% (95% CI 3.3%-3.4%) with marked regional variation. We identified significant associations between mean annual Land Surface Temperature (LST), mean annual precipitation, topography of the land and fine soil texture and high prevalence of podoconiosis. The derived maps indicate both widespread occurrence of podoconiosis and a marked variability in prevalence of podoconiosis, with prevalence typically highest at altitudes >1500 m above sea level (masl), with >1500 mm annual rainfall and mean annual LST of 19-21°C. No (or very little) podoconiosis occurred at altitudes <1225 masl, with annual rainfall <900 mm, and mean annual LST of >24°C. Podoconiosis remains a public health problem in Ethiopia over considerable areas of the country, but exhibits marked geographical variation associated in part with key environmental factors. This is work in progress and the results presented here will be refined in future work.

Improved Mapping of Human Population and Settlements through Integration of Remote Sensing and Socioeconomic Data

NASA Astrophysics Data System (ADS)

de Sherbinin, A. M.; Yetman, G.; MacManus, K.; Vinay, S.

2017-12-01

The diversity of data on human settlements, infrastructure, and population continues to grow rapidly, with recent releases of data products based on a range of different remote sensing data sources as well as census and administrative data. We report here on recent improvements in data from the NASA Socioeconomic Data and Applications Center (SEDAC) and partner organizations, aimed at supporting both interdisciplinary research and real-world applications. The fourth version of SEDAC's Gridded Population of the World (GPWv4) now includes variables for age categories, gender, and urban/rural location, and has also been integrated with the Global Human Settlements (GHS) data developed by the Joint Research Centre of the European Commission to produce a GHS-POP grid for the years 1975, 1990, 2000 and 2015. Through a collaboration between Facebook's Connectivity Lab and the Center for International Earth Science Information Network (CIESIN), High Resolution Settlement Layer (HRSL) data derived from 50-cm DigitalGlobe imagery are now available for selected developing countries at 30-m resolution. SEDAC is also developing interactive mapping and analysis tools to facilitate visualization and access to these often large and complex data products. For example, SEDAC has collaborated with scientists from NASA's Goddard Space Flight Center to release the Global Man-made Impervious Surfaces & Settlement Extents from Landsat data at 30-m resolution through an innovative map interface. We also summarize recent progress in developing an international data collective that is bringing together both data developers and data users from the public and private sectors to collaborate on expanding data access and use, improving data quality and documentation, facilitating data intercomparison and integration, and sharing of resources and capabilities.

Mechanisms for renal blood flow control early in diabetes as revealed by chronic flow measurement and transfer function analysis.

PubMed

Bell, Tracy D; DiBona, Gerald F; Wang, Ying; Brands, Michael W

2006-08-01

The purpose of this study was to establish the roles of the myogenic response and the TGF mechanism in renal blood flow (RBF) control at the very earliest stages of diabetes. Mean arterial pressure (MAP) and RBF were measured continuously, 18 h/d, in uninephrectomized control and diabetic rats, and transfer function analysis was used to determine the dynamic autoregulatory efficiency of the renal vasculature. During the control period, MAP averaged 91 +/- 0.5 and 89 +/- 0.4 mmHg, and RBF averaged 8.0 +/- 0.1 and 7.8 +/- 0.1 ml/min in the control and diabetic groups, respectively. Induction of diabetes with streptozotocin caused a marked and progressive increase in RBF in the diabetic rats, averaging 10 +/- 6% above control on day 1 of diabetes and 22 +/- 3 and 34 +/- 1% above control by the end of diabetes weeks 1 and 2. MAP increased approximately 9 mmHg during the 2 wk in the diabetic rats, and renal vascular resistance decreased. Transfer function analysis revealed significant increases in gain to positive values over the frequency ranges of both the TGF and myogenic mechanisms, beginning on day 1 of diabetes and continuing through day 14. These very rapid increases in RBF and transfer function gain suggest that autoregulation is impaired at the very onset of hyperglycemia in streptozotocin-induced type 1 diabetes and may play an important role in the increase in RBF and GFR in diabetes. Together with previous reports of decreases in chronically measured cardiac output and hindquarter blood flow, this suggests that there may be differential effects of diabetes on RBF versus nonrenal BF control.

Environmental conditions associated with bat white-nose syndrome in the north-eastern United States

USGS Publications Warehouse

Flory, Abigail R.; Kumar, Sunil; Stohlgren, Thomas J.; Cryan, Paul M.

2012-01-01

2. By 2010, the fungus G. destructans was detected in new areas of North America far from the area it was first observed, as well as in eight European bat species in different countries, yet mortality was not observed in many of these new areas of North America or in any part of Europe. This could be because of the differences in the fungus, rates of disease progression and/or in life-history or physiological traits of the affected bat species between different regions. Infection of bats by G. destructans without associated mortality might also suggest that certain environmental conditions might have to co-occur with fungal infection to cause mortality. 3. We tested the environmental conditions hypothesis using Maxent to map and model landscape surface conditions associated with WNS mortality. This approach was unique in that we modelled possible requisite environmental conditions for disease mortality and not simply the presence of the causative agent. 4. The top predictors of WNS mortality were land use/land cover types, mean air temperature of wettest quarter, elevation, frequency of precipitation and annual temperature range. Model results suggest that WNS mortality is most likely to occur in landscapes that are higher in elevation and topographically heterogeneous, drier and colder during winter, and more seasonally variable than surrounding landscapes. 5. Synthesis and applications. This study mapped the most likely environmental surface conditions associated with bat mortality owing to WNS in the north-eastern United Sates; maps can be used for selection of priority monitoring sites. Our results provide a starting point from which to investigate and predict the potential spread and population impacts of this catastrophic emerging disease.