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Sample records for rapid iterative stimulation

  1. Online Classrooms: Powerful Tools for Rapid-Iteration Pedagogical Improvements

    NASA Astrophysics Data System (ADS)

    Horodyskyj, L.; Semken, S.; Anbar, A.; Buxner, S.

    2015-11-01

    Online education offers the opportunity to reach a variety of students including non-traditional and geographically diverse students. Research has shown that online courses modeled after traditional lecture-exam courses are ineffective. Over the past three years, Arizona State University developed and offered Habitable Worlds, an online-only astrobiology lab course featuring active learning tools. The course is offered in an intelligent tutoring system (ITS) that records a wealth of student data. In analyzing data from the Fall 2013 offering of the course, we were able to identify pre-post quiz results that were suboptimal and where in the lesson and how precisely students were missing concepts. The problem areas were redesigned, and the improved lessons were deployed a few months later. We saw significant improvements in our pre-post quiz results due to the implemented changes. This demonstrates the effectiveness of using robust ITS not only to present content online, but to provide instantaneous data for rapid iteration and improvement of existing content.

  2. Iter

    NASA Astrophysics Data System (ADS)

    Iotti, Robert

    2015-04-01

    ITER is an international experimental facility being built by seven Parties to demonstrate the long term potential of fusion energy. The ITER Joint Implementation Agreement (JIA) defines the structure and governance model of such cooperation. There are a number of necessary conditions for such international projects to be successful: a complete design, strong systems engineering working with an agreed set of requirements, an experienced organization with systems and plans in place to manage the project, a cost estimate backed by industry, and someone in charge. Unfortunately for ITER many of these conditions were not present. The paper discusses the priorities in the JIA which led to setting up the project with a Central Integrating Organization (IO) in Cadarache, France as the ITER HQ, and seven Domestic Agencies (DAs) located in the countries of the Parties, responsible for delivering 90%+ of the project hardware as Contributions-in-Kind and also financial contributions to the IO, as ``Contributions-in-Cash.'' Theoretically the Director General (DG) is responsible for everything. In practice the DG does not have the power to control the work of the DAs, and there is not an effective management structure enabling the IO and the DAs to arbitrate disputes, so the project is not really managed, but is a loose collaboration of competing interests. Any DA can effectively block a decision reached by the DG. Inefficiencies in completing design while setting up a competent organization from scratch contributed to the delays and cost increases during the initial few years. So did the fact that the original estimate was not developed from industry input. Unforeseen inflation and market demand on certain commodities/materials further exacerbated the cost increases. Since then, improvements are debatable. Does this mean that the governance model of ITER is a wrong model for international scientific cooperation? I do not believe so. Had the necessary conditions for success

  3. Upper limb stroke rehabilitation: the effectiveness of Stimulation Assistance through Iterative Learning (SAIL).

    PubMed

    Meadmore, Katie L; Cai, Zhonglun; Tong, Daisy; Hughes, Ann-Marie; Freeman, Chris T; Rogers, Eric; Burridge, Jane H

    2011-01-01

    A novel system has been developed which combines robotic therapy with electrical stimulation (ES) for upper limb stroke rehabilitation. This technology, termed SAIL: Stimulation Assistance through Iterative Learning, employs advanced model-based iterative learning control (ILC) algorithms to precisely assist participant's completion of 3D tracking tasks with their impaired arm. Data is reported from a preliminary study with unimpaired participants, and also from a single hemiparetic stroke participant with reduced upper limb function who has used the system in a clinical trial. All participants completed tasks which involved moving their (impaired) arm to follow an image of a slowing moving sphere along a trajectory. The participants' arm was supported by a robot and ES was applied to the triceps brachii and anterior deltoid muscles. During each task, the same tracking trajectory was repeated 6 times and ILC was used to compute the stimulation signals to be applied on the next iteration. Unimpaired participants took part in a single, one hour training session and the stroke participant undertook 18, 1 hour treatment sessions composed of tracking tasks varying in length, orientation and speed. The results reported describe changes in tracking ability and demonstrate feasibility of the SAIL system for upper limb rehabilitation. PMID:22275698

  4. A rapid and robust iterative closest point algorithm for image guided radiotherapy

    NASA Astrophysics Data System (ADS)

    Barbiere, Joseph; Hanley, Joseph

    2008-03-01

    Our work presents a rapid and robust process that can analytically evaluate and correct patient setup error for head and neck radiotherapy by comparing orthogonal megavoltage portal images with digitally reconstructed radiographs. For robust data Photoshop is used to interactively segment images and registering reference contours to the transformed PI. MatLab is used for matrix computations and image analysis. The closest point distance for each PI point to a DRR point forms a set of homologous points. The translation that aligns the PI to the DRR is equal to the difference in centers of mass. The original PI points are transformed and the process repeated with an Iterative Closest Point algorithm until the transformation change becomes negligible. Using a 3.00 GHz processor the calculation of the 2500x1750 CPD matrix takes about 150 sec per iteration. Standard down sampling to about 1000 DRR and 250 PI points significantly reduces that time. We introduce a local neighborhood matrix consisting of a small subset of the DRR points in the vicinity of each PI point to further reduce the CPD matrix size. Our results demonstrate the effects of down sampling on accuracy. For validation, analytical detailed results are displayed as a histogram.

  5. Sparsely corrupted stimulated scattering signals recovery by iterative reweighted continuous basis pursuit

    SciTech Connect

    Wang, Kunpeng; Chai, Yi; Su, Chunxiao

    2013-08-15

    In this paper, we consider the problem of extracting the desired signals from noisy measurements. This is a classical problem of signal recovery which is of paramount importance in inertial confinement fusion. To accomplish this task, we develop a tractable algorithm based on continuous basis pursuit and reweighted ℓ{sub 1}-minimization. By modeling the observed signals as superposition of scale time-shifted copies of theoretical waveform, structured noise, and unstructured noise on a finite time interval, a sparse optimization problem is obtained. We propose to solve this problem through an iterative procedure that alternates between convex optimization to estimate the amplitude, and local optimization to estimate the dictionary. The performance of the method was evaluated both numerically and experimentally. Numerically, we recovered theoretical signals embedded in increasing amounts of unstructured noise and compared the results with those obtained through popular denoising methods. We also applied the proposed method to a set of actual experimental data acquired from the Shenguang-II laser whose energy was below the detector noise-equivalent energy. Both simulation and experiments show that the proposed method improves the signal recovery performance and extends the dynamic detection range of detectors.

  6. Rapid assessment of gait and speech after subthalamic deep brain stimulation

    PubMed Central

    Farris, Sierra M.; Giroux, Monique L.

    2016-01-01

    Background: Describe a rapid assessment for patients with idiopathic Parkinson's disease (PD) and deep brain stimulation of the subthalamic nucleus reporting worsening speech and/or gait problems. Methods: We retrospectively reviewed 29 patients that had improvement in gait and/or speech within 30 min after turning stimulation off. Clinical data analyzed include unified PD rating scale motor scores and stimulation parameters before and after adjusting stimulation. All patients received electrode efficacy and side effect threshold testing. Stimulation parameters were adjusted to maximize efficacy, avoid side effects, and maximize battery longevity. Results: Turning stimulation off revealed reversible speech and/or gait stimulation side effects within 30 min. Focusing on six factors revealed stimulation modifications that improved motor symptoms, eliminated stimulation side effects, and reduced battery drain. Primary stimulation parameters modified were cathode selection and pulse width reduction. Conclusions: Stimulation-induced side effects impacting gait and speech can be identified within 30 min. A systematic evaluation can distinguish disease progression from reversible stimulation side effects and improve motor outcomes over the long term. PMID:27583181

  7. Rapid identification of efficient target cleavage sites using a hammerhead ribozyme library in an iterative manner.

    PubMed

    Pan, Wei-Hua; Xin, Ping; Bui, Vuong; Clawson, Gary A

    2003-01-01

    A major limitation to the effectiveness of ribozymes is definition of accessible sites in targeted RNAs. Although library selection procedures have been developed, they are generally difficult to perform and have not been widely employed. Here we describe a selection technology that utilizes a randomized, active hammerhead ribozyme (Rz) library in an iterative manner. After two rounds of binding under inactive conditions, the selected, active Rz library is incubated with target RNA, and the sites of cleavage are identified on sequencing gels. We performed this library-selection protocol using human papillomavirus type 16 E6/E7 mRNA as target and constructed Rz targeted to the identified sites. Rz targeted to sites identified with this procedure were generally highly active in vitro and, more importantly, they were highly active in cell culture, whereas their catalytically inactive counterparts were not. This protocol can be used to identify a set of potential target sites within a relatively short time.

  8. Using Functional Electrical Stimulation Mediated by Iterative Learning Control and Robotics to Improve Arm Movement for People With Multiple Sclerosis.

    PubMed

    Sampson, Patrica; Freeman, Chris; Coote, Susan; Demain, Sara; Feys, Peter; Meadmore, Katie; Hughes, Ann-Marie

    2016-02-01

    Few interventions address multiple sclerosis (MS) arm dysfunction but robotics and functional electrical stimulation (FES) appear promising. This paper investigates the feasibility of combining FES with passive robotic support during virtual reality (VR) training tasks to improve upper limb function in people with multiple sclerosis (pwMS). The system assists patients in following a specified trajectory path, employing an advanced model-based paradigm termed iterative learning control (ILC) to adjust the FES to improve accuracy and maximise voluntary effort. Reaching tasks were repeated six times with ILC learning the optimum control action from previous attempts. A convenience sample of five pwMS was recruited from local MS societies, and the intervention comprised 18 one-hour training sessions over 10 weeks. The accuracy of tracking performance without FES and the amount of FES delivered during training were analyzed using regression analysis. Clinical functioning of the arm was documented before and after treatment with standard tests. Statistically significant results following training included: improved accuracy of tracking performance both when assisted and unassisted by FES; reduction in maximum amount of FES needed to assist tracking; and less impairment in the proximal arm that was trained. The system was well tolerated by all participants with no increase in muscle fatigue reported. This study confirms the feasibility of FES combined with passive robot assistance as a potentially effective intervention to improve arm movement and control in pwMS and provides the basis for a follow-up study.

  9. Rapid and transitory stimulation of 3-O-methylglucose transport by growth hormone

    SciTech Connect

    Carter-Su, C.; Rozsa, F.W.; Wang, Xueyan; Stubbart, J.R. )

    1988-11-01

    The regulation of hexose transport by growth hormone (GH) was investigated using isolated rat adipocytes. GH caused a rapid (<3 min) rise in rates of 3-O-methylglucose transport that reached a maximum of two to six times the basal rates in 10-30 min. The stimulation of transport was transitory, and rates of transport started to decline 15-30 min after GH was added. Transport stimulation required a period of preincubation; no stimulation was observed in freshly isolated cells. GH stimulated hexose transport between 100 and 5,000 ng/ml, with a 50% effective dose between 200 and 300 ng/ml. Depletion of cellular ATP by 2,4-dinitrophenol blocked the ability of GH to stimulate transport but not the decline of transport rates following stimulation by GH. In contrast, an inhibitor of RNA synthesis, actinomycin D, had no effect on either the initial stimulation by GH or the initial subsequent decline of transport when added simultaneously or 15 min prior to GH. Actinomycin D did, however, cause a second rise in hexose transport at {approximately}120 min that was blocked by 2,4-dinitrophenol. These results suggest that changes in glucose transport contribute to the effects of GH on carbohydrate and lipid metabolism in adipose tissue. These changes are rapid, of substantial magnitude, and of a complex nature, suggesting that regulation of glucose transport by GH most likely involves multiple mechanisms.

  10. Thyroid-stimulating hormone rapidly stimulates inositol polyphosphate formation in FRTL-5 thyrocytes without activating phosphoinositidase C.

    PubMed Central

    Singh, J; Hunt, P; Eggo, M C; Sheppard, M C; Kirk, C J; Michell, R H

    1996-01-01

    The thyroid-stimulating hormone (TSH) receptor is widely regarded as one of a limited number of G-protein-coupled receptors that activate both adenylate cyclase and phosphoinositidase C (PIC) via G-proteins, but the existing experimental evidence for TSH-stimulated PtdIns(4,5)P2 hydrolysis remains inconclusive. We have compared the effects of TSH and of ATP (acting via P2-purinergic receptors) on the inositol lipids and polyphosphates of [2-3H]inositol-labelled FRTL-5 rat thyroid cells. ATP initiated a rapid decrease in 3H-labelled PtdIns4P and PtdIns(4,5)P2, whereas TSH did not. Stimulation with ATP and, less consistently, with noradrenaline (acting via alpha-adrenergic receptors) provoked rapid formation of Ins(1,4,5)P3, Ins(1,3,4,5)P4, Ins(1,3,4)P3 and Ins(1,4)P2, confirming activation of PtdIns(4,5)P2 hydrolysis. No concentration of TSH provoked detectable accumulation of Ins(1,4,5)P3 or Ins(1,4)P2 during the first few minutes of stimulation. However, an InsP3 [with the chromatographic properties of Ins(1,3,4)P3] and two InsP4 isomers [neither of which was Ins(1,3,4,5)P4] accumulated quickly in TSH-stimulated cells. ATP immediately provoked a large increase in intracellular calcium concentration ([Ca2+]i) in Indo 1-AM-loaded cells. TSH provoked a small and delayed [Ca2+]i elevation in only some experiments. We therefore confirm that activation of P2-purinergic receptors and alpha 1-adrenergic receptors provokes PIC activation, an accumulation of Ins(1,4,5)P3 and its metabolites and rapid [Ca2+]i mobilization in FRTL-5 cells. By contrast, TSH provokes no rapid PIC-catalysed PtdIns(4,5)P2 hydrolysis or immediate [Ca2+]i mobilization. These results fail to support the widespread view that the TSH receptor of FRTL-5 cells signals, in part, through PIC activation. Our results suggest that TSH activates another, still undefined, mechanism that causes accumulation of an InsP3 and two isomers of InsP4. PMID:8645202

  11. Dissociation between mossy fiber sprouting and rapid kindling with low-frequency stimulation of the amygdala.

    PubMed

    Armitage, L L; Mohapel, P; Jenkins, E M; Hannesson, D K; Corcoran, M E

    1998-01-19

    In an attempt to determine whether sprouting of mossy fibers is invariably correlated with kindling of seizures, we subjected rats to rapid kindling with long trains of low-frequency stimulation of the amygdala that resulted in development of generalized seizures within a mean of five stimulations. For comparison, we subjected other rats to conventional kindling with short trains of high-frequency stimulation of the amygdala that resulted in development of generalized seizures within a mean of 13 stimulations. We found no evidence of mossy fiber sprouting in the dentate gyrus of rats killed one day after completion of rapid kindling, as compared to yoked controls, although significant sprouting was seen in rats killed one day after completion of conventional kindling. When we examined tissue from rats killed 20 days after rapid kindling, however, we did find significant sprouting, suggesting that mossy fiber sprouting can be triggered by rapid kindling if sufficient survival time is allowed. The observed disparity between completion of rapid low-frequency kindling and detection of mossy fiber sprouting suggests that mossy fiber sprouting may be associated more with sustained survival time after neuronal activation than with kindling per se. Furthermore, the similar time course of conventional kindling and of mossy fiber sprouting obscures the determination of a causal role of mossy fiber sprouting in conventional kindling.

  12. Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries

    PubMed Central

    2015-01-01

    Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement. In this study, we show that by characterizing the binding constants for all of the hits that arise from a screen, structure–activity relationship (SAR) data can be obtained to inform the design of “derivative libraries” of a primary hit that can then be screened under more demanding conditions to obtain improved compounds. Here, we demonstrate the rapid improvement of a primary hit against matrix metalloproteinase-14 using this approach. PMID:25434974

  13. Electrical stimulation causes rapid changes in electrode impedance of cell-covered electrodes

    NASA Astrophysics Data System (ADS)

    Newbold, Carrie; Richardson, Rachael; Millard, Rodney; Seligman, Peter; Cowan, Robert; Shepherd, Robert

    2011-06-01

    Animal and clinical observations of a reduction in electrode impedance following electrical stimulation encouraged the development of an in vitro model of the electrode-tissue interface. This model was used previously to show an increase in impedance with cell and protein cover over electrodes. In this paper, the model was used to assess the changes in electrode impedance and cell cover following application of a charge-balanced biphasic current pulse train. Following stimulation, a large and rapid drop in total impedance (Zt) and access resistance (Ra) occurred. The magnitude of this impedance change was dependent on the current amplitude used, with a linear relationship determined between Ra and the resulting cell cover over the electrodes. The changes in impedance due to stimulation were shown to be transitory, with impedance returning to pre-stimulation levels several hours after cessation of stimulation. A loss of cells over the electrode surface was observed immediately after stimulation, suggesting that the level of stimulation applied was creating localized changes to cell adhesion. Similar changes in electrode impedance were observed for in vivo and in vitro work, thus helping to verify the in vitro model, although the underlying mechanisms may differ. A change in the porosity of the cellular layer was proposed to explain the alterations in electrode impedance in vitro. These in vitro studies provide insight into the possible mechanisms occurring at the electrode-tissue interface in association with electrical stimulation.

  14. Electrical stimulation causes rapid changes in electrode impedance of cell-covered electrodes

    PubMed Central

    Newbold, Carrie; Richardson, Rachael; Millard, Rodney; Seligman, Peter; Cowan, Robert; Shepherd, Robert

    2011-01-01

    Animal and clinical observations of a reduction in electrode impedance following electrical stimulation encouraged the development of an in vitro model of the electrode-tissue interface. This model was used previously to show an increase in impedance with cell and protein cover over electrodes. In this paper, the model was used to assess the changes in electrode impedance and cell cover following application of a charge-balanced biphasic current pulse train. Following stimulation, a large and rapid drop in total impedance (Zt) and access resistance (Ra) occurred. The magnitude of this impedance change was dependent on the current amplitude used, with a linear relationship determined between Ra and the resulting cell cover over the electrodes. The changes in impedance due to stimulation were shown to be transitory, with impedance returning to pre-stimulation levels several hours after cessation of stimulation. A loss of cells over the electrode surface was observed immediately after stimulation suggesting that the level of stimulation applied was creating localised changes to cell adhesion. Similar changes in electrode impedance were observed for in vivo and in vitro work, thus helping to verify the in vitro model, although the underlying mechanisms may differ. A change in the porosity of the cellular layer was proposed to explain the alterations in electrode impedance in vitro. These in vitro studies provide insight into the possible mechanisms occurring at the electrode-tissue interface in association with electrical stimulation. PMID:21572219

  15. Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

    PubMed Central

    Fuchikami, Manabu; Thomas, Alexandra; Liu, Rongjian; Wohleb, Eric S.; Land, Benjamin B.; DiLeone, Ralph J.; Aghajanian, George K.; Duman, Ronald S.

    2015-01-01

    Ketamine produces rapid and sustained antidepressant actions in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here we determined if modulation of neuronal activity in the infralimbic prefrontal cortex (IL-PFC) underlies the antidepressant and anxiolytic actions of ketamine. We found that neuronal inactivation of the IL-PFC completely blocked the antidepressant and anxiolytic effects of systemic ketamine in rodent models and that ketamine microinfusion into IL-PFC reproduced these behavioral actions of systemic ketamine. We also found that optogenetic stimulation of the IL-PFC produced rapid and long-lasting antidepressant and anxiolytic effects and that these effects are associated with increased number and function of spine synapses of layer V pyramidal neurons. The results demonstrate that ketamine infusions or optogenetic stimulation of IL-PFC are sufficient to produce long-lasting antidepressant behavioral and synaptic responses similar to the effects of systemic ketamine administration. PMID:26056286

  16. ITER Plasma at Electron Cyclotron Frequency Domain: Stimulated Raman Scattering off Gould-Trivelpiece Modes and Generation of Suprathermal Electrons and Energetic Ions

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2011-04-01

    Stimulated Raman scattering in the electron cyclotron frequency range of the X-Mode and O-Mode driver with the ITER plasma leads to the ``tail heating'' via the generation of suprathermal electrons and energetic ions. The scattering off Trivelpiece-Gould (T-G) modes is studied for the gyrotron frequency of 170GHz; X-Mode and O-Mode power of 24 MW CW; on-axis B-field of 10T. The synergy between the two-plasmon decay and Raman scattering is analyzed in reference to the bulk plasma heating. Supported in part by Nikola TESLA Labs, La Jolla, CA

  17. ITER Plasma at Electron Cyclotron Frequency Domain: Tokamak Core Plasma Diagnostics Based on the Synergy of Stimulated Raman and Brillouin Scatterings

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2012-10-01

    A novel plasma diagnostic method is proposed based on the synergy of stimulated Raman and Brillouin scatterings. A nonlinear plasma mode is excited in a 4-wave coupling,footnotetextV. Alexander STEFAN, Nonlinear Electromagnetic Radiation Plasma Interactions, (S-U-Press, 2008). leading to the appearance of suprathermal electrons and accelerated ions at the plasma edgefootnotetextV. Alexander Stefan, Abstract: D1.00018 : ITER Plasma at Electron Cyclotron Frequency Domain: Stimulated Raman Scattering off Gould-Trivelpiece Modes and Generation of Suprathermal Electrons and Energetic Ions; Bulletin of the American Physical Society APS April Meeting 2011 Volume 56, Number 4. with the parameters directly dependent on the plasma parameters in the core of tokamak. Accordingly, plasma diagnostic in the core region, (ion temperature), can be performed by the diagnostics of suprathermal electrons and accelerated ions at the edge plasma.

  18. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood.

    PubMed

    Pascual-Leone, A; Catalá, M D; Pascual-Leone Pascual, A

    1996-02-01

    We studied the effects of rapid-rate transcranial magnetic stimulation (rTMS) of different scalp positions on mood. Ten normal volunteers rated themselves before and after rTMS on five analog scales labeled "Tristeza" (Sadness), "Ansiedad" (Anxiety), "Alegria" (Happiness), "Cansancio" (Tiredness), and "Dolor/Malestar" (Pain/Discomfort). rTMS was applied to the right lateral prefrontal, left prefrontal, or midline frontal cortex in trains of 5 seconds' duration at 10 Hz and 110% of the subject's motor threshold intensity. Each stimulation position received 10 trains separated by a 25-second pause. No clinically apparent mood changes were evoked by rTMS to any of the scalp positions in any subject. However, left prefrontal rTMS resulted in a significant increase in the Sadness ratings (Tristeza) and a significant decrease in the Happiness ratings ("Alegria") as compared with right prefrontal and midfrontal cortex stimulation. These results show differential effects of rTMS of left and right prefrontal cortex stimulation on mood and illustrate the lateralized control of mood in normal volunteers. PMID:8614521

  19. [Transesophageal rapid stimulation of the left atrium in atrial tachycardias (author's transl)].

    PubMed

    Sterz, H; Prager, H; Koller, H

    1978-02-01

    A new method to interrupt atrial tachycardias is reported. With an esophageal double-electrode the left atrium is stimulated with an external pacemaker at rates of 400 per minute and with 10 to 20 mAmp; The rhythm-disturbances treated in this way were: atrial tachycardias with constant or inconstant blocks and paroxysmal supraventricular tachycardias. 7 of 9 cases reported showed positive results, i.e. electrically induced atrial fibrillation and sinusrhythm immediately or within the first hour after stopping the pacer (6) or atrial fibrillation after disconnection from the pacer at a lower heart-rate than before (1). In 2 cases the technique was applied without success. The transoesophageal rapid left atrial stimulation (oeRLAS) is painless, can be applied without sterile measures and even without X-ray-control just by observing the oesophageal Ecg. Digitalisation is unimportant. The technique described may prove useful in cases of atrial tachycardias esp; in intensive care units. PMID:636520

  20. Stimulation of pulmonary rapidly adapting receptors by inhaled wood smoke in rats.

    PubMed

    Lai, C J; Kou, Y R

    1998-04-15

    1. The stimulation of pulmonary rapidly adapting receptors (RARs) by wood smoke was investigated. Impulses from seventy RARs were recorded in fifty-nine anaesthetized, open-chest and artificially ventilated rats; responses to delivery of 6 ml of wood smoke into the lungs were studied in sixty-one receptors whereas responses to histamine (10 or 100 microg kg-1, i.v.) were studied in the other nine. 2. Delivery of wood smoke stimulated fifty-two of the sixty-one RARs studied. When stimulated, an intense burst of discharge was evoked within 1 or 2 s of smoke delivery. This increased activity quickly peaked in 1-3 s (Delta = 15.8 +/- 1.6 impulses s-1; n = 61; mean +/- s.e.m.), then declined and yet remained at a level higher than the baseline activity. The mean duration of the stimulation was 25.1 +/- 2.7 s. In contrast, smoke delivery did not affect tracheal pressure. 3. Peak responses of RARs to wood smoke were partially reduced by removal of smoke particulates and were largely attenuated by pretreatment with dimethylthiourea (DMTU, a hydroxyl radical scavenger), indomethacin (Indo, a cyclo-oxygenase inhibitor), or both DMTU and Indo (DMTU + Indo). Conversely, the peak responses of RARs were not significantly affected by pretreatment with isoprenaline (a bronchodilator) or vehicle for these chemicals. Additionally, pretreatment with DMTU, Indo, or DMTU + Indo did not significantly alter the RAR sensitivity to mechanical stimulation (constant-pressure lung inflation; 20 cmH2O). 4. Of the nine RARs tested, six were stimulated by histamine and their sensitivity to this chemical irritant was not altered by pretreatment with DMTU + Indo. 5. The results suggest that both the particulates and gas phases are responsible for, and both the hydroxyl radical and cyclo-oxygenase products are involved in, the stimulation of RARs by wood smoke. Furthermore, changes in lung mechanics following smoke delivery are not the cause of this afferent stimulation. PMID:9508820

  1. The Role of ATP in Mechanically Stimulated Rapid Closure of the Venus's Flytrap.

    PubMed

    Jaffe, M J

    1973-01-01

    When the midribs of untreated traps of Dionaea muscipula are frozen in liquid nitrogen after rapid closure, they contain significantly less ATP than those frozen before closure. Exogenous ATP causes a significant increase in the rate of mechanically stimulated trap closure. Illuminated traps close faster than those kept in the dark. The traps of plants placed in 100% O(2) close much faster than do air controls, while 100% CO(2) inhibits closure. It is concluded that ATP is probably the native source of potential energy for contraction of the trap's midrib, and that if the endogenous ATP titer is increased by oxidative phosphorylation or an exogenous source, the trap will close faster.

  2. Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator.

    PubMed

    Kong, Lingjie; Ji, Minbiao; Holtom, Gary R; Fu, Dan; Freudiger, Christian W; Xie, X Sunney

    2013-01-15

    Stimulated Raman scattering (SRS) microscopy allows label-free chemical imaging based on vibrational spectroscopy. Narrowband excitation with picosecond lasers creates the highest signal levels and enables imaging speeds up to video-rate, but it sacrifices chemical specificity in samples with overlapping bands compared to broadband (multiplex) excitation. We develop a rapidly tunable picosecond optical parametric oscillator with an electro-optical tunable Lyot filter, and demonstrate multicolor SRS microscopy with synchronized line-by-line wavelength tuning to avoid spectral artifacts due to sample movement. We show sensitive imaging of three different kinds of polymer beads and live HeLa cells with moving intracellular lipid droplets.

  3. Stimulants

    MedlinePlus

    Stimulants are drugs that increase your heart rate, breathing rate, and brain function. Some stimulants affect only a specific organ, such as the heart, lungs, brain, or nervous system. Epinephrine is a stimulant. It ...

  4. ITER Plasma at Ion Cyclotron Frequency Domain: The Fusion Alpha Particles Diagnostics Based on the Stimulated Raman Scattering of Fast Magnetosonic Wave off High Harmonic Ion Bernstein Modes

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2014-10-01

    A novel method for alpha particle diagnostics is proposed. The theory of stimulated Raman scattering, SRS, of the fast wave and ion Bernstein mode, IBM, turbulence in multi-ion species plasmas, (Stefan University Press, La Jolla, CA, 2008). is utilized for the diagnostics of fast ions, (4)He (+2), in ITER plasmas. Nonlinear Landau damping of the IBM on fast ions near the plasma edge leads to the space-time changes in the turbulence level, (inverse alpha particle channeling). The space-time monitoring of the IBM turbulence via the SRS techniques may prove efficient for the real time study of the fast ion velocity distribution function, spatial distribution, and transport. Supported by Nikola Tesla Labs., La Jolla, CA 92037.

  5. Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words.

    PubMed

    Lou, Hans C; Skewes, Joshua C; Thomsen, Kristine Rømer; Overgaard, Morten; Lau, Hakwan C; Mouridsen, Kim; Roepstorff, Andreas

    2011-02-23

    Liberal acceptance, overconfidence, and increased activity of the neurotransmitter dopamine have been proposed to account for abnormal sensory experiences, for instance, hallucinations in schizophrenia. In normal subjects, increased sensory experience in Yoga Nidra meditation is linked to striatal dopamine release. We therefore hypothesize that the neurotransmitter dopamine may function as a regulator of subjective confidence of visual perception in the normal brain. Although much is known about the effect of stimulation by neurotransmitters on cognitive functions, their effect on subjective confidence of perception has never been recorded experimentally before. In a controlled study of 24 normal, healthy female university students with the dopamine agonist pergolide given orally, we show that dopaminergic activation increases confidence in seeing rapidly presented words. It also improves performance in a forced-choice word recognition task. These results demonstrate neurotransmitter regulation of subjective conscious experience of perception and provide evidence for a crucial role of dopamine.

  6. Rapid systemic up-regulation of genes after heat-wounding and electrical stimulation

    NASA Technical Reports Server (NTRS)

    Davies, E.; Vian, A.; Vian, C.; Stankovic, B.

    1997-01-01

    When one leaf of a tomato plant is electrically-stimulated or heat-wounded, proteinase inhibitor genes are rapidly up-regulated in distant leaves. The identity of the systemic wound signal(s) is not yet known, but major candidates include hormones transmitted via the phloem or the xylem, the electrically-stimulated self-propagating electrical signal in the phloem (the action potential, AP), or the heat-wound-induced surge in hydraulic pressure in the xylem evoking a local change in membrane potential in adjacent living cells (the variation potential, VP). In order to discriminate between these signals we have adopted two approaches. The first approach involves applying stimuli that evoke known signals and determining whether these signals have similar effects on the "model" transcripts for proteinase inhibitors (pin) and calmodulin (cal). Here we show that a heat wound almost invariably evokes a VP, while an electrical stimulation occasionally evokes an AP, and both of these signals induce accumulation of transcripts encoding proteinase inhibitors. The second approach involves identifying the array of genes turned on by heat-wounding. To this end, we have constructed a subtractive library for heat-wounded tissue, isolated over 800 putatively up-regulated clones, and shown that all but two of the fifty that we have analyzed by Northern hybridization are, indeed, up-regulated. Here we show the early kinetics of up-regulation of three of these transcripts in the terminal (4th) leaf in response to heat-wounding the 3rd leaf, about 5 cm away. Even though these transcripts show somewhat different time courses of induction, with one peaking at 30 min, another at 15 min, and another at 5 min after flaming of a distant leaf, they all exhibit a similar pattern, i.e., a transient period of transcript accumulation preceding a period of transcript decrease, followed by a second period of transcript accumulation.

  7. Rapid auxin-induced stimulation of cell wall synthesis in pea internodes

    SciTech Connect

    Kutschera, U.; Briggs, W.R.

    1987-05-01

    The effect of auxin (indole-3-acetic acid; IAA) on growth and incorporation of myo-(2-/sup 3/H(N)) inositol ((/sup 3/H)Ins) into noncellulosic polysacchharides in the cell walls of third internode sections from red light-grown pea seedlings (Pisum sativum L. cv. Alaska) was investigated. Intact section were incubated on (/sup 3/H)Ins for 4 hr to permit uptake of the tracer and then IAA was added. Growth started after a lag phase of 15 min under these conditions. The sections were removed from the tracer and separated into epidermis and cortical cylinder (cortex plus vascular tissue). In the epidermis, IAA-induced stimulation of (/sup 3/H)Ins incorporation started after a lag of 15 min. The amount of incorporation was 15% higher after 30 min and 24% higher after 2 hr than in the control. In the cortical cylinder, IAA-induced stimulation of (/sup 3/H)Ins incorporation started only approx. = 1 hr after adding IAA. The ionophore monensin (20 ..mu..M) inhibited the IAA-induced growth by 95%. Under these conditions, the IAA-induced stimulation of (/sup 3/H)Ins incorporation and the IAA-induced increase in in vivo extensibility of the sections was almost completely inhibited, although oxygen uptake was unaffected. The authors suggest that wall synthesis (as represented by (/sup 3/H)Ins incorporation) and wall loosening (increase in in vivo extensibility) are related processes. The results support the hypothesis that IAA induces growth by rapid simulation of cell wall synthesis in the growth-limiting epidermal cell layer.

  8. A microcontroller platform for the rapid prototyping of functional electrical stimulation-based gait neuroprostheses.

    PubMed

    Luzio de Melo, Paulo; da Silva, Miguel Tavares; Martins, Jorge; Newman, Dava

    2015-05-01

    Functional electrical stimulation (FES) has been used over the last decades as a method to rehabilitate lost motor functions of individuals with spinal cord injury, multiple sclerosis, and post-stroke hemiparesis. Within this field, researchers in need of developing FES-based control solutions for specific disabilities often have to choose between either the acquisition and integration of high-performance industry-level systems, which are rather expensive and hardly portable, or develop custom-made portable solutions, which despite their lower cost, usually require expert-level electronic skills. Here, a flexible low-cost microcontroller-based platform for rapid prototyping of FES neuroprostheses is presented, designed for reduced execution complexity, development time, and production cost. For this reason, the Arduino open-source microcontroller platform was used, together with off-the-shelf components whenever possible. The developed system enables the rapid deployment of portable FES-based gait neuroprostheses, being flexible enough to allow simple open-loop strategies but also more complex closed-loop solutions. The system is based on a modular architecture that allows the development of optimized solutions depending on the desired FES applications, even though the design and testing of the platform were focused toward drop foot correction. The flexibility of the system was demonstrated using two algorithms targeting drop foot condition within different experimental setups. Successful bench testing of the device in healthy subjects demonstrated these neuroprosthesis platform capabilities to correct drop foot. PMID:25919579

  9. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells

    SciTech Connect

    Zachary, I.; Gil, J.; Lehmann, W.; Sinnett-Smith, J.; Rozengurt, E. )

    1991-06-01

    The mitogenic neuropeptides bombesin and vasopressin markedly increased tyrosine and serine phosphorylation of multiple substrates in quiescent Swiss 3T3 fibroblasts, including two major bands of M{sub r} 90,000 and 115,000. Tyrosine phosphorylation of these proteins was increased as judged by immunoprecipitation of {sup 32}P{sub i}-labeled cells and immunoblotting of unlabeled cells with monoclonal antiphosphotyrosine antibodies, elution with phenyl phosphate, and phospho amino acid analysis. Phosphotyrosyl proteins generated by bombesin and vasopressin did not correspond either by apparent molecular weight or by immunological and biochemical criteria to several known tyrosine kinase substrates, including phospholipase C{sub {gamma}}, the microtubule-associated protein 2 kinase, GTPase-activating protein, or phosphatidylinositol kinase. The effect was rapid (within seconds), concentration dependent, and inhibited by specific receptor antagonists for both bombesin and vasopressin. The endothelin-related peptide, vasoactive intestinal contractor, also elicited a rapid and concentration-dependent tyrosine/serine phosphorylation of a similar set of substrates. These results demonstrate that neuropeptides, acting through receptors linked to GTP-binding proteins, stimulate tyrosine phosphorylation of a common set of substrates in quiescent Swiss 3T3 cells and suggest the existence of an additional signal transduction pathway in neuropeptide-induced mitogenesis.

  10. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

    PubMed

    Case, Christopher L; Kohler, Lara J; Lima, Jonilson B; Strowig, Till; de Zoete, Marcel R; Flavell, Richard A; Zamboni, Dario S; Roy, Craig R

    2013-01-29

    A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here we demonstrate that this pathway requires caspase-11. Treatment of macrophages with LPS up-regulated the host components required for this caspase-11 activation pathway. Activation by Legionella differed from caspase-11 activation using previously described agonists in that Legionella caspase-11 activation was rapid and required bacteria with a functional type IV secretion system called Dot/Icm. Legionella activation of caspase-11 induced pyroptosis by a mechanism independent of the NAIP/NLRC4 and caspase-1 axis. Legionella activation of caspase-11 stimulated activation of caspase-1 through NLRP3 and ASC. Induction of caspase-11-dependent responses occurred in macrophages deficient in the adapter proteins TRIF or MyD88 but not in macrophages deficient in both signaling factors. Although caspase-11 was produced in macrophages deficient in the type-I IFN receptor, there was a severe defect in caspase-11-dependent pyroptosis in these cells. These data indicate that macrophages respond to microbial signatures to produce proteins that mediate a capsase-11 response and that the caspase-11 system provides an alternative pathway for rapid detection of an intracellular pathogen capable of evading the canonical caspase-1 activation system that responds to bacterial flagellin. PMID:23307811

  11. Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy

    PubMed Central

    Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y.R.; Young, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney

    2013-01-01

    Surgery is an essential component in the treatment of brain tumors. However, delineating tumor from normal brain remains a major challenge. Here we describe the use of stimulated Raman scattering (SRS) microscopy for differentiating healthy human and mouse brain tissue from tumor-infiltrated brain based on histoarchitectural and biochemical differences. Unlike traditional histopathology, SRS is a label-free technique that can be rapidly performed in situ. SRS microscopy was able to differentiate tumor from non-neoplastic tissue in an infiltrative human glioblastoma xenograft mouse model based on their different Raman spectra. We further demonstrated a correlation between SRS and H&E microscopy for detection of glioma infiltration (κ=0.98). Finally, we applied SRS microscopy in vivo in mice during surgery to reveal tumor margins that were undetectable under standard operative conditions. By providing rapid intraoperative assessment of brain tissue, SRS microscopy may ultimately improve the safety and accuracy of surgeries where tumor boundaries are visually indistinct. PMID:24005159

  12. Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts

    NASA Technical Reports Server (NTRS)

    Johnson, D. L.; McAllister, T. N.; Frangos, J. A.

    1996-01-01

    Interstitial fluid flow may mediate skeletal remodeling in response to mechanical loading. Because nitric oxide (NO) has been shown to be an osteoblast mitogen and inhibitor of osteoclastic resorption, we investigated and characterized the role of fluid shear on the release of NO in osteoblasts. Rat calvarial cells in a stationary culture produced undetectable levels of NO. Fluid shear stress (6 dyn/cm2) rapidly increased NO release rate to 9.8 nmol.h-1.mg protein-1 and sustained this production for 12 h of exposure to flow. Cytokine treatment also induced NO synthesis after a 12-h lag phase of zero production, followed by a production rate of 0.6 nmol.h-1.mg protein-1. Flow-induced NO production was blocked by the NO synthase (NOS) inhibitor NG-amino-L-arginine, but not by dexamethasone, which suggests that the flow stimulated a constitutive NOS isoform. This is the first time that a functional constitutively present NOS isoform has been identified in osteoblasts. Moreover, fluid flow represents the most potent stimulus of NO release in osteoblasts reported to date. Fluid flow-induced NO production may therefore play a primary role in bone maintenance and remodeling.

  13. Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes.

    PubMed

    Nakashima, Tadamitsu; Ohkusa, Tomoko; Okamoto, Yoko; Yoshida, Masaaki; Lee, Jong-Kook; Mizukami, Yoichi; Yano, Masafumi

    2014-05-01

    The intercellular junctions contain two complexes, adhesion junctions (AJ) and connexin (Cx) gap junctions (GJs). GJs provide the pathway for intercellular current flow. AJs mediate normal mechanical coupling and play an important role in the stability of GJs. We investigated the effects of rapid electrical stimulation (RES) on cardiac intercellular junctions, especially β-catenin and Cx43 alterations. We also studied the effects of ANG II receptor blockade on intercellular junction remodeling. Neonatal rats were euthanized by decapitation, and cardiomyocytes were prepared, cultured, and subjected to RES. We used real-time PCR, western blot analysis, and immunohistochemical methods. Conduction properties were examined by an extracellular potential mapping system. Cx43 protein expression in cardiomyocytes was significantly increased after 60 min. β-Catenin expression in the total cell fraction was significantly increased after 30 min. The expression level of β-catenin in the nucleus, which functions as a T cell factor/lymphocyte enhancer binding factor transcriptional activator of Cx43 with its degradation regulated by glycogen synthase kinase-3β, was dramatically increased after 10 min. Conduction velocity was increased significantly by RES for 60 min. Olmesartan prevented most these effects of RES. We showed an increase of phosphorylated glycogen synthase kinase-3β, which is phosphorylated by activated MAPKs and inhibits β-catenin degradation, was attenuated by olmesartan. The changes in β-catenin precede Cx43 GJ remodeling and might play an important role in the formation and stability of GJs. Olmesartan might be a new upstream arrhythmia therapy by modulating intercellular junction remodeling through the β-catenin signaling pathway.

  14. Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifiers of Aβ(42)-induced locomotor decline in Drosophila.

    PubMed

    Liu, Haiyan; Han, Meng; Li, Qingyi; Zhang, Xiao; Wang, Wen-An; Huang, Fu-De

    2015-10-01

    The negative-geotaxis climbing assay is used to efficiently study aging and neurodegeneration in Drosophila. To make it suitable for large-scale study, a method called the rapid iterative negative geotaxis (RING) assay has been established by simultaneously photographing the climbing of multiple groups of flies when they are manually tapped down in test tubes. Here, we automated the assay by using a well-controlled electric motor to drive the tapping, and a homemade program to analyze the climbing height of flies. Using the automated RING (aRING) assay, we found that the climbing ability of a strain of wild-type flies, males in particular, declined rapidly before day 21 after eclosion, but slowly from day 21 to 35. We also found that the expression of arctic mutant Aβ42 accelerated the age-dependent decline in the climbing ability of flies. Moreover, using aRING, we examined the effect of third chromosome deficiencies on the accelerated locomotor decline in Aβ42-expressing flies, and isolated 7 suppressors and 15 enhancers. PMID:26077703

  15. Courtship interactions stimulate rapid changes in GnRH synthesis in male ring doves

    PubMed Central

    Mantei, Kristen E.; Ramakrishnan, Selvakumar; Sharp, Peter J.; Buntin, John D.

    2008-01-01

    Many birds and mammals show changes in the hypothalamo-pituitary-gonadal (HPG) axis in response to social or sexual interactions between breeding partners. While alterations in GnRH neuronal activity play an important role in stimulating these changes, it remains unclear if acute behaviorally-induced alterations in GnRH release are accompanied by parallel changes in GnRH synthesis. To investigate this relationship, we examined changes in the activity of GnRH neurons in the brains of male ring doves following brief periods of courtship interactions with females. Such interactions have been previously shown to increase plasma LH in courting male doves at 24 h, but not at 1 h, after pairing with females. In the first study, males allowed to court females for 2 h had 60% more cells that showed immunocytochemical labeling for GnRH-I in the preoptic area (POA) of the hypothalamus than did control males that remained isolated from females. To determine whether an increase in GnRH gene expression preceded this increase in GnRH immunoreactivity in the POA, changes in the number of cells with detectable GnRH-I mRNA in the POA were measured by in situ hybridization following a 1 h period of courtship interactions with females. In this second study, courting males exhibited 40% more cells with GnRH-I in this region than did isolated control males. GnRH-immunoreactive neurons in two other diencephalic regions failed to show these courtship-induced changes. Plasma LH was not elevated after 1 or 2 h of courtship. These results demonstrate that the release of GnRH-I in the POA that is presumably responsible for courtship-induced pituitary and gonadal activation is accompanied by a rapid increase in GnRH synthesis that occurs before plasma LH levels increase. We suggest that this increase in GnRH synthesis is necessary to support the extended period of HPG axis activation that is seen in this species during the 5–10 day period of courtship and nest building activity. PMID

  16. Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.

    PubMed

    Larsen, Lars E; Wadman, Wytse J; Marinazzo, Daniele; van Mierlo, Pieter; Delbeke, Jean; Daelemans, Sofie; Sprengers, Mathieu; Thyrion, Lisa; Van Lysebettens, Wouter; Carrette, Evelien; Boon, Paul; Vonck, Kristl; Raedt, Robrecht

    2016-07-01

    Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 μA, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy. PMID:27102987

  17. Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.

    PubMed

    Larsen, Lars E; Wadman, Wytse J; Marinazzo, Daniele; van Mierlo, Pieter; Delbeke, Jean; Daelemans, Sofie; Sprengers, Mathieu; Thyrion, Lisa; Van Lysebettens, Wouter; Carrette, Evelien; Boon, Paul; Vonck, Kristl; Raedt, Robrecht

    2016-07-01

    Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 μA, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy.

  18. Rapid relief of thalamic pain syndrome induced by vestibular caloric stimulation.

    PubMed

    Ramachandran, Vilayanur S; McGeoch, Paul D; Williams, Lisa; Arcilla, Gerard

    2007-06-01

    Central post-stroke pain syndrome develops in a minority of patients following a stroke. The most usual causative lesion involves the lateral thalamus. The classic presentation is of severe, unrelenting pain that involves the entire contralateral half of the body. It is largely refractory to current treatments. We found that in two patients with this condition their pain was substantially improved by vestibular caloric stimulation, whereas placebo procedures had no effect. We proposed that this is because vestibular stimulation activates the posterior insula, which in turn inhibits the generation of pain in the anterior cingulate.

  19. Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder

    PubMed Central

    de Koning, P P; Figee, M; Endert, E; van den Munckhof, P; Schuurman, P R; Storosum, J G; Denys, D; Fliers, E

    2016-01-01

    Improvement of obsessions and compulsions by deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) is often preceded by a rapid and transient mood elevation (hypomania). In a previous study we showed that improvement of mood by DBS for OCD is associated with a decreased activity of the hypothalamus–pituitary adrenal axis. The aim of our present study was to evaluate the time course of rapid clinical changes following DBS reactivation in more detail and to assess their association with additional neuroendocrine parameters. We included therapy-refractory OCD patients treated with DBS (>1 year) and performed a baseline assessment of symptoms, as well as plasma concentrations of thyroid-stimulating hormone (TSH), prolactin, growth hormone, copeptin and homovanillic acid. This was repeated after a 1-week DBS OFF condition. Next, we assessed the rapid effects of DBS reactivation by measuring psychiatric symptom changes using visual analog scales as well as repeated neuroendocrine measures after 30 min, 2 h and 6 h. OCD, anxiety and depressive symptoms markedly increased during the 1-week OFF condition and decreased again to a similar extent already 2 h after DBS reactivation. We found lower plasma prolactin (41% decrease, P=0.003) and TSH (39% decrease, P=0.003) levels during DBS OFF, which increased significantly already 30 min after DBS reactivation. The rapid and simultaneous increase in TSH and prolactin is likely to result from stimulation of hypothalamic thyrotropin-releasing hormone (TRH), which may underlie the commonly observed transient mood elevation following DBS. PMID:26812043

  20. Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder.

    PubMed

    de Koning, P P; Figee, M; Endert, E; van den Munckhof, P; Schuurman, P R; Storosum, J G; Denys, D; Fliers, E

    2016-01-01

    Improvement of obsessions and compulsions by deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) is often preceded by a rapid and transient mood elevation (hypomania). In a previous study we showed that improvement of mood by DBS for OCD is associated with a decreased activity of the hypothalamus-pituitary adrenal axis. The aim of our present study was to evaluate the time course of rapid clinical changes following DBS reactivation in more detail and to assess their association with additional neuroendocrine parameters. We included therapy-refractory OCD patients treated with DBS (>1 year) and performed a baseline assessment of symptoms, as well as plasma concentrations of thyroid-stimulating hormone (TSH), prolactin, growth hormone, copeptin and homovanillic acid. This was repeated after a 1-week DBS OFF condition. Next, we assessed the rapid effects of DBS reactivation by measuring psychiatric symptom changes using visual analog scales as well as repeated neuroendocrine measures after 30 min, 2 h and 6 h. OCD, anxiety and depressive symptoms markedly increased during the 1-week OFF condition and decreased again to a similar extent already 2 h after DBS reactivation. We found lower plasma prolactin (41% decrease, P=0.003) and TSH (39% decrease, P=0.003) levels during DBS OFF, which increased significantly already 30 min after DBS reactivation. The rapid and simultaneous increase in TSH and prolactin is likely to result from stimulation of hypothalamic thyrotropin-releasing hormone (TRH), which may underlie the commonly observed transient mood elevation following DBS. PMID:26812043

  1. Behavioral responses of deafened guinea pigs to intracochlear electrical stimulation: a new rapid psychophysical procedure.

    PubMed

    Agterberg, Martijn J H; Versnel, Huib

    2014-07-01

    In auditory research the guinea pig is often preferred above rats and mice because of the easily accessible cochlea and because the frequency range of its hearing is more comparable to that of humans. Studies of the guinea-pig auditory system primarily apply histological and electrophysiological measures. Behavioral animal paradigms, in particular in combination with these histological and electrophysiological methods, are necessary in the development of new therapeutic interventions. However, the guinea pig is not considered an attractive animal for behavioral experiments. Therefore, the purpose of this study was to develop a behavioral task suitable for guinea pigs, that can be utilized in cochlear-implant related research. Guinea pigs were trained in a modified shuttle-box in which a stream of air was used as unconditioned stimulus (UCS). A stream of air was preferred over conventionally used methods as electric foot-shocks since it produces less stress, which is a confounding factor in behavioral experiments. Hearing guinea pigs were trained to respond to acoustic stimuli. They responded correctly within only five sessions of ten minutes. The animals maintained their performance four weeks after the right cochlea was implanted with an electrode array. After systemic deafening, the animals responded in the first session immediately to intracochlear electrical stimulation. These responses were not affected by daily chronic electrical stimulation (CES). In conclusion, the present study demonstrates that guinea pigs can be trained relatively fast to respond to acoustic stimuli, and that the training has a lasting effect, which generalizes to intracochlear electrical stimulation after deafening. Furthermore, it demonstrates that bilaterally deafened guinea pigs with substantial (∼50%) loss of spiral ganglion cells (SGCs), detect intracochlear electrical stimulation.

  2. Robust iterative methods

    SciTech Connect

    Saadd, Y.

    1994-12-31

    In spite of the tremendous progress achieved in recent years in the general area of iterative solution techniques, there are still a few obstacles to the acceptance of iterative methods in a number of applications. These applications give rise to very indefinite or highly ill-conditioned non Hermitian matrices. Trying to solve these systems with the simple-minded standard preconditioned Krylov subspace methods can be a frustrating experience. With the mathematical and physical models becoming more sophisticated, the typical linear systems which we encounter today are far more difficult to solve than those of just a few years ago. This trend is likely to accentuate. This workshop will discuss (1) these applications and the types of problems that they give rise to; and (2) recent progress in solving these problems with iterative methods. The workshop will end with a hopefully stimulating panel discussion with the speakers.

  3. Revisiting the yeast PPR proteins--application of an Iterative Hidden Markov Model algorithm reveals new members of the rapidly evolving family.

    PubMed

    Lipinski, Kamil A; Puchta, Olga; Surendranath, Vineeth; Kudla, Marek; Golik, Pawel

    2011-10-01

    Pentatricopeptide repeat (PPR) proteins are the largest known RNA-binding protein family, and are found in all eukaryotes, being particularly abundant in higher plants. PPR proteins localize mostly to mitochondria and chloroplasts, and many were shown to modulate organellar genome expression on the posttranscriptional level. Although the genomes of land plants encode hundreds of PPR proteins, only a few have been identified in Fungi and Metazoa. As the current PPR motif profiles are built mainly on the basis of the predominant plant sequences, they are unlikely to be optimal for detecting fungal and animal members of the family, and many putative PPR proteins in these genomes may remain undetected. In order to verify this hypothesis, we designed a hidden Markov model-based bioinformatic tool called Supervised Clustering-based Iterative Phylogenetic Hidden Markov Model algorithm for the Evaluation of tandem Repeat motif families (SCIPHER) using sequence data from orthologous clusters from available yeast genomes. This approach allowed us to assign 12 new proteins in Saccharomyces cerevisiae to the PPR family. Similarly, in other yeast species, we obtained a 5-fold increase in the detection of PPR motifs, compared with the previous tools. All the newly identified S. cerevisiae PPR proteins localize in the mitochondrion and are a part of the RNA processing interaction network. Furthermore, the yeast PPR proteins seem to undergo an accelerated divergent evolution. Analysis of single and double amino acid substitutions in the Dmr1 protein of S. cerevisiae suggests that cooperative interactions between motifs and pseudoreversion could be the force driving this rapid evolution.

  4. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes

    SciTech Connect

    Radogna, Flavia; Paternoster, Laura; De Nicola, Milena; Cerella, Claudia; Ammendola, Sergio; Bedini, Annalida; Tarzia, Giorgio; Aquilano, Katia; Ciriolo, Maria; Ghibelli, Lina

    2009-08-15

    Melatonin is a modified tryptophan with potent biological activity, exerted by stimulation of specific plasma membrane (MT1/MT2) receptors, by lower affinity intracellular enzymatic targets (quinone reductase, calmodulin), or through its strong anti-oxidant ability. Scattered studies also report a perplexing pro-oxidant activity, showing that melatonin is able to stimulate production of intracellular reactive oxygen species (ROS). Here we show that on U937 human monocytes melatonin promotes intracellular ROS in a fast (< 1 min) and transient (up to 5-6 h) way. Melatonin equally elicits its pro-radical effect on a set of normal or tumor leukocytes; intriguingly, ROS production does not lead to oxidative stress, as shown by absence of protein carbonylation, maintenance of free thiols, preservation of viability and regular proliferation rate. ROS production is independent from MT1/MT2 receptor interaction, since a) requires micromolar (as opposed to nanomolar) doses of melatonin; b) is not contrasted by the specific MT1/MT2 antagonist luzindole; c) is not mimicked by a set of MT1/MT2 high affinity melatonin analogues. Instead, chlorpromazine, the calmodulin inhibitor shown to prevent melatonin-calmodulin interaction, also prevents melatonin pro-radical effect, suggesting that the low affinity binding to calmodulin (in the micromolar range) may promote ROS production.

  5. 17beta-estradiol and tamoxifen stimulate rapid and transient ERK activationin MCF-7 cells via distinct signaling mechanisms.

    PubMed

    Visram, Hasina; Greer, Peter A

    2006-12-01

    Traditionally, estrogen signaling was thought to be mediated strictly through genomic pathways. Recently, however, it has been demonstrated that estrogen stimulation of cells leads to rapid nongenomic effects including ERK activation. While the precise mechanism of this action is still under investigation, it is known that activation of the epidermal growth factor receptor, the Src tyrosine kinase, and metalloproteinases are involved in this process. More recently, tamoxifen, an anti-hormonal agent used to treat breast cancer, has been shown to also activate ERK. The pathways by which it does so, however, are not known. Using the MCF-7 human breast carcinoma cell line as a model system, we show that ERK is rapidly and transiently activated in cells challenged with epidermal growth factor (EGF), 17beta-estradiol (E2) or tamoxifen. The ERK activation response to E2 and tamoxifen was kinetically similar, although the response to tamoxifen was delayed relative to that of E2 stimulation. The effect of the EGFR inhibitor AG1517 revealed that E2 and tamoxifen were both equally dependent on EGFR for activation of ERK. In contrast, inhibition of Src or metalloproteinases caused distinct effects on ERK activation by E2 and tamoxifen. Thus, while both E2 and tamoxifen induced activation of ERK, the differences in the effects of inhibitors of Src or metalloproteinases on ERK activation indicated that E2 and tamoxifen do so via distinct molecular mechanisms.

  6. Rapid touch-stimulated movement in the androgynophore of Passiflora flowers (subgen. Decaloba; Sect. Xerogona)

    PubMed Central

    Scorza, Livia CT; Dornelas, Marcelo Carnier

    2014-01-01

    Plant touch-sensitive organs have been described since Darwin’s observations and are related to a quick response to environment stimuli. Sensitive flower organs have been associated to an increase in the chances of cross pollination but there are few studies regarding this topic. Here we describe for the first time the kinetic of the androgynophore movement of 4 Passiflora species (P. sanguinolenta, P. citrina, P. capsularis, and P. rubra). For that, we collected flowers and recorded the movement after mechano-stimulating the androgynophore. From the recordings, we described the movement regarding its response and sensibility to mechanical stimulus and calculated the duration, speed, and the angle formed by the androgynophore before and after the movement. From our data we were able to propose a link to the pollination habit of these species. The movement of the androgynophore in these Passiflora is a noteworthy floral feature that might lead us to another astonishing example of a mechanism that evolved among angiosperms to assure sexual reproduction. PMID:24487079

  7. Mega-prizes in medicine: big cash awards may stimulate useful and rapid therapeutic innovation.

    PubMed

    Charlton, Bruce G

    2007-01-01

    Following Horrobin's suggestion of 1986, I argue that offering very large prizes (tens of millions of US dollars, or more) for solving specific therapeutic problems, would be an excellent strategy for promoting the rapid development of effective new treatments. The two mainstream ways of paying for medical research are funding the process with grants or funding the outcome via patent protection. When grants are used to fund the process of research the result tends to be 'pure' science, guided by intrinsic scientific objectives. Practical results, such as useful therapeutic advances, are a by-product. Patent-seeking research, by contrast, is more focused on technology than science. It seeks practical results; and aims to pay for itself (and make a profit) in the long term by generating a patentable product or procedure. Prize-seeking research is subject to different incentives and applicable to different situations than either process-funded or patent-seeking research. Prize seeking researchers have a strong incentive to solve the specified problem as rapidly as possible, but the problem may be solved using old ideas that are scientifically mundane or unpatentable technologies and methods. Prizes therefore seem to generate solutions which are incremental extensions, new applications or novel combinations of already-existing technologies. The main use of mega-prizes in medicine would be to accelerate therapeutic progress in stagnant fields of research and to address urgent problems. For example, medical charities focused on specific diseases should consider accumulating their resources until they can offer a mega-prize for solving a clinical problem of special concern to their patients. Prize money should be big enough to pay for the research and development, the evaluation of the new treatment in a clinical trial, and with a large profit left-over to compensate for the intrinsic risk of competing. Sufficiently large amounts of money, and the prestige and publicity

  8. The Non-Benzodiazepine Anxiolytic Drug Etifoxine Causes a Rapid, Receptor-Independent Stimulation of Neurosteroid Biosynthesis

    PubMed Central

    do Rego, Jean Luc; Vaudry, David; Vaudry, Hubert

    2015-01-01

    Neurosteroids can modulate the activity of the GABAA receptors, and thus affect anxiety-like behaviors. The non-benzodiazepine anxiolytic compound etifoxine has been shown to increase neurosteroid concentrations in brain tissue but the mode of action of etifoxine on neurosteroid formation has not yet been elucidated. In the present study, we have thus investigated the effect and the mechanism of action of etifoxine on neurosteroid biosynthesis using the frog hypothalamus as an experimental model. Exposure of frog hypothalamic explants to graded concentrations of etifoxine produced a dose-dependent increase in the biosynthesis of 17-hydroxypregnenolone, dehydroepiandrosterone, progesterone and tetrahydroprogesterone, associated with a decrease in the production of dihydroprogesterone. Time-course experiments revealed that a 15-min incubation of hypothalamic explants with etifoxine was sufficient to induce a robust increase in neurosteroid synthesis, suggesting that etifoxine activates steroidogenic enzymes at a post-translational level. Etifoxine-evoked neurosteroid biosynthesis was not affected by the central-type benzodiazepine (CBR) receptor antagonist flumazenil, the translocator protein (TSPO) antagonist PK11195 or the GABAA receptor antagonist bicuculline. In addition, the stimulatory effects of etifoxine and the triakontatetraneuropeptide TTN, a TSPO agonist, were additive, indicating that these two compounds act through distinct mechanisms. Etifoxine also induced a rapid stimulation of neurosteroid biosynthesis from frog hypothalamus homogenates, a preparation in which membrane receptor signalling is disrupted. In conclusion, the present study demonstrates that etifoxine stimulates neurosteroid production through a membrane receptor-independent mechanism. PMID:25785994

  9. Flash-and-Freeze: Coordinating Optogenetic Stimulation with Rapid Freezing to Visualize Membrane Dynamics at Synapses with Millisecond Resolution

    PubMed Central

    Watanabe, Shigeki

    2016-01-01

    Electron microscopy depicts subcellular structures at synapses exquisitely but only captures static images. To visualize membrane dynamics, we have developed a novel technique, called flash-and-freeze, which induces neuronal activity with a flash of light and captures the membrane dynamics by rapid freezing. For characterizing membrane movements during synaptic transmission, a light-sensitive cation channel, channelrhodopsin, is heterologously expressed in mouse hippocampal neurons or in Caenorhabditis elegans motor neurons. A brief pulse of blue light activates channelrhodopsin and induces an action potential, leading to synaptic transmission. Following the light stimulation, neurons are frozen at different time intervals ranging from 10 ms to 20 s. Electron micrographs are then acquired from each time point to visualize the morphological changes. Using this approach, we have characterized a novel form of endocytosis, ultrafast endocytosis, which rapidly removes excess membrane added to the surface during neurotransmission. The flash-and-freeze approach can be adapted to study other cellular phenomena that can be induced by light-sensitive genetic or pharmacological tools.

  10. Flash-and-Freeze: Coordinating Optogenetic Stimulation with Rapid Freezing to Visualize Membrane Dynamics at Synapses with Millisecond Resolution.

    PubMed

    Watanabe, Shigeki

    2016-01-01

    Electron microscopy depicts subcellular structures at synapses exquisitely but only captures static images. To visualize membrane dynamics, we have developed a novel technique, called flash-and-freeze, which induces neuronal activity with a flash of light and captures the membrane dynamics by rapid freezing. For characterizing membrane movements during synaptic transmission, a light-sensitive cation channel, channelrhodopsin, is heterologously expressed in mouse hippocampal neurons or in Caenorhabditis elegans motor neurons. A brief pulse of blue light activates channelrhodopsin and induces an action potential, leading to synaptic transmission. Following the light stimulation, neurons are frozen at different time intervals ranging from 10 ms to 20 s. Electron micrographs are then acquired from each time point to visualize the morphological changes. Using this approach, we have characterized a novel form of endocytosis, ultrafast endocytosis, which rapidly removes excess membrane added to the surface during neurotransmission. The flash-and-freeze approach can be adapted to study other cellular phenomena that can be induced by light-sensitive genetic or pharmacological tools. PMID:27594835

  11. Flash-and-Freeze: Coordinating Optogenetic Stimulation with Rapid Freezing to Visualize Membrane Dynamics at Synapses with Millisecond Resolution

    PubMed Central

    Watanabe, Shigeki

    2016-01-01

    Electron microscopy depicts subcellular structures at synapses exquisitely but only captures static images. To visualize membrane dynamics, we have developed a novel technique, called flash-and-freeze, which induces neuronal activity with a flash of light and captures the membrane dynamics by rapid freezing. For characterizing membrane movements during synaptic transmission, a light-sensitive cation channel, channelrhodopsin, is heterologously expressed in mouse hippocampal neurons or in Caenorhabditis elegans motor neurons. A brief pulse of blue light activates channelrhodopsin and induces an action potential, leading to synaptic transmission. Following the light stimulation, neurons are frozen at different time intervals ranging from 10 ms to 20 s. Electron micrographs are then acquired from each time point to visualize the morphological changes. Using this approach, we have characterized a novel form of endocytosis, ultrafast endocytosis, which rapidly removes excess membrane added to the surface during neurotransmission. The flash-and-freeze approach can be adapted to study other cellular phenomena that can be induced by light-sensitive genetic or pharmacological tools. PMID:27594835

  12. Pressure overload stimulated cardiac hypertrophy leads to a rapid decrease in the mRNA for creatine kinase

    SciTech Connect

    Boheler, K.; Popovich, B.; Dillmann, W.H.

    1987-05-01

    Cardiac hypertrophy (CH) leads to a decrease in creatine kinase (CK) enzymatic activity. To determine if the mRNA for CK also decreases with CH, they performed the following studies. Cardiac RNA was isolated from rats subjected to either abdominal aortic stenosis (AS) or sham surgery. Through Northern blot analysis, total cardiac RNA was quantitated with a CK specific /sup 32/P-labelled cDNA clone. At 3 and 8 days post-constriction, the mRNA for CK decreases by 54.6 +/- 7% and 65.3 +/- 18% respectively, whereas the heart weight increases by 19% and 37% relative to controls. Further studies indicate that CK mRNA also decreases by 41.8% in hypothyroid rats (Tx) but decreases by a total of 68.1% in Tx rats subjected to 8 days of AS. Pressure overload stimulated CH leads to a rapid decrease in CK mRNA in normal and Tx rats. This CK mRNA decrease may account for the decreased efficiency of contraction seen in CH.

  13. β-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart.

    PubMed

    Garg, Vivek; Taylor, Tyson; Warren, Mark; Venable, Paul; Sciuto, Katie; Shibayama, Junko; Zaitsev, Alexey

    2015-05-01

    Global ischemia, catecholamine surge, and rapid heart rhythm (RHR) due to ventricular tachycardia or ventricular fibrillation (VF) are the three major factors of sudden cardiac arrest (SCA). Loss of excitability culminating in global electrical failure (asystole) is the major adverse outcome of SCA with increasing prevalence worldwide. The roles of catecholamines and RHR in the electrical failure during SCA remain unclear. We hypothesized that both β-adrenergic stimulation (βAS) and RHR accelerate electrical failure in the globally ischemic heart. We performed optical mapping of the action potential (OAP) in the right ventricular (RV) and left (LV) ventricular epicardium of isolated rabbit hearts subjected to 30-min global ischemia. Hearts were paced at a cycle length of either 300 or 200 ms, and either in the presence or in the absence of β-agonist isoproterenol (30 nM). 2,3-Butanedione monoxime (20 mM) was used to reduce motion artifact. We found that RHR and βAS synergistically accelerated the decline of the OAP upstroke velocity and the progressive expansion of inexcitable regions. Under all conditions, inexcitability developed faster in the LV than in the RV. At the same time, both RHR and βAS shortened the time to VF (TVF) during ischemia. Moreover, the time at which 10% of the mapped LV area became inexcitable strongly correlated with TVF (R(2) = 0 .72, P < 0.0001). We conclude that both βAS and RHR are major factors of electrical depression and failure in the globally ischemic heart and may contribute to adverse outcomes of SCA such as asystole and recurrent/persistent VF.

  14. β-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart

    PubMed Central

    Garg, Vivek; Taylor, Tyson; Warren, Mark; Venable, Paul; Sciuto, Katie; Shibayama, Junko

    2015-01-01

    Global ischemia, catecholamine surge, and rapid heart rhythm (RHR) due to ventricular tachycardia or ventricular fibrillation (VF) are the three major factors of sudden cardiac arrest (SCA). Loss of excitability culminating in global electrical failure (asystole) is the major adverse outcome of SCA with increasing prevalence worldwide. The roles of catecholamines and RHR in the electrical failure during SCA remain unclear. We hypothesized that both β-adrenergic stimulation (βAS) and RHR accelerate electrical failure in the globally ischemic heart. We performed optical mapping of the action potential (OAP) in the right ventricular (RV) and left (LV) ventricular epicardium of isolated rabbit hearts subjected to 30-min global ischemia. Hearts were paced at a cycle length of either 300 or 200 ms, and either in the presence or in the absence of β-agonist isoproterenol (30 nM). 2,3-Butanedione monoxime (20 mM) was used to reduce motion artifact. We found that RHR and βAS synergistically accelerated the decline of the OAP upstroke velocity and the progressive expansion of inexcitable regions. Under all conditions, inexcitability developed faster in the LV than in the RV. At the same time, both RHR and βAS shortened the time to VF (TVF) during ischemia. Moreover, the time at which 10% of the mapped LV area became inexcitable strongly correlated with TVF (R2 = 0 .72, P < 0.0001). We conclude that both βAS and RHR are major factors of electrical depression and failure in the globally ischemic heart and may contribute to adverse outcomes of SCA such as asystole and recurrent/persistent VF. PMID:25713306

  15. The ITER project construction status

    NASA Astrophysics Data System (ADS)

    Motojima, O.

    2015-10-01

    The pace of the ITER project in St Paul-lez-Durance, France is accelerating rapidly into its peak construction phase. With the completion of the B2 slab in August 2014, which will support about 400 000 metric tons of the tokamak complex structures and components, the construction is advancing on a daily basis. Magnet, vacuum vessel, cryostat, thermal shield, first wall and divertor structures are under construction or in prototype phase in the ITER member states of China, Europe, India, Japan, Korea, Russia, and the United States. Each of these member states has its own domestic agency (DA) to manage their procurements of components for ITER. Plant systems engineering is being transformed to fully integrate the tokamak and its auxiliary systems in preparation for the assembly and operations phase. CODAC, diagnostics, and the three main heating and current drive systems are also progressing, including the construction of the neutral beam test facility building in Padua, Italy. The conceptual design of the Chinese test blanket module system for ITER has been completed and those of the EU are well under way. Significant progress has been made addressing several outstanding physics issues including disruption load characterization, prediction, avoidance, and mitigation, first wall and divertor shaping, edge pedestal and SOL plasma stability, fuelling and plasma behaviour during confinement transients and W impurity transport. Further development of the ITER Research Plan has included a definition of the required plant configuration for 1st plasma and subsequent phases of ITER operation as well as the major plasma commissioning activities and the needs of the accompanying R&D program to ITER construction by the ITER parties.

  16. Effect of low-frequency electrical stimulation parameters on its anticonvulsant action during rapid perforant path kindling in rat.

    PubMed

    Shahpari, Marzieh; Mirnajafi-Zadeh, Javad; Firoozabadi, Seyed Mohammad P; Yadollahpour, Ali

    2012-03-01

    Low frequency stimulation (LFS) may be considered as a new potential therapy for drug-resistant epilepsy. However, the relation between LFS parameters and its anticonvulsant effects is not completely determined. In this study, the effect of some LFS parameters on its anticonvulsant action was investigated in rats. In all animals, stimulating and recording electrodes were implanted into the perforant path and dentate gyrus, respectively. In one group of animals, kindling stimulations were applied until rats achieved a fully kindled state. In other groups, different patterns of LFS were applied at the end of kindling stimulations during twenty consecutive days. In the first experiment the effect of LFS pulse numbers was investigated on its anticonvulsant action. Animals were divided randomly into three groups and 1, 4, and 8 packages of LFS (each pack contains 200 pulses, 0.1 ms pulse duration at 1 Hz) were applied five minutes after termination of kindling stimulations. Obtained results showed that 4 packages of LFS had the strongest anticonvulsant effects. Therefore, this pattern (4 packages) was used in the next experiment. In the second experiment, 4 packages of LFS were applied at intervals of 30 s and 30 min after termination of kindling stimulations. The strongest anticonvulsant effect was observed in the group received LFS at the interval of 30 s. Therefore, this pattern was selected for the third experiment. In the third experiment the effect of LFS at frequencies of 0.25 Hz and 5 Hz was investigated. The group of animals which received LFS at the frequency of 0.25 Hz showed somehow stronger anticonvulsant effect. The results indicate that different parameters of LFS have important role in induction of LFS anticonvulsant effects. Regarding this view, it seems that the slower LFS frequency and the shorter interval between LFS and kindling stimulations, the stronger anticonvulsant effect will be observed. But there is no direct relation between number of

  17. Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells.

    PubMed

    Massey, Katherine J; Li, Quanwen; Rossi, Noreen F; Keezer, Susan M; Mattingly, Raymond R; Yingst, Douglas R

    2016-02-01

    How angiotensin (ANG) II acutely stimulates the Na-K pump in proximal tubules is only partially understood, limiting insight into how ANG II increases blood pressure. First, we tested whether ANG II increases the number of pumps in plasma membranes of native rat proximal tubules under conditions of rapid activation. We found that exposure to 100 pM ANG II for 2 min, which was previously shown to increase affinity of the Na-K pump for Na and stimulate activity threefold, increased the amount of the Na-K pump in plasma membranes of native tubules by 33%. Second, we tested whether previously observed increases in phosphorylation of the Na-K pump at Ser(938) were part of the stimulatory mechanism. These experiments were carried out in opossum kidney cells, cultured proximal tubules stably coexpressing the ANG type 1 (AT1) receptor, and either wild-type or a S938A mutant of rat kidney Na-K pump under conditions found by others to stimulate activity. We found that 10 min of incubation in 10 pM ANG II stimulated activity of wild-type pumps from 2.3 to 3.5 nmol K · mg protein(-1) · min(-1) and increased the amount of the pump in the plasma membrane by 80% but had no effect on cells expressing the S938A mutant. We conclude that acute stimulation of Na-K pump activity in native rat proximal tubules includes increased trafficking to the plasma membrane and that phosphorylation at Ser(938) is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells. PMID:26582472

  18. Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells.

    PubMed

    Massey, Katherine J; Li, Quanwen; Rossi, Noreen F; Keezer, Susan M; Mattingly, Raymond R; Yingst, Douglas R

    2016-02-01

    How angiotensin (ANG) II acutely stimulates the Na-K pump in proximal tubules is only partially understood, limiting insight into how ANG II increases blood pressure. First, we tested whether ANG II increases the number of pumps in plasma membranes of native rat proximal tubules under conditions of rapid activation. We found that exposure to 100 pM ANG II for 2 min, which was previously shown to increase affinity of the Na-K pump for Na and stimulate activity threefold, increased the amount of the Na-K pump in plasma membranes of native tubules by 33%. Second, we tested whether previously observed increases in phosphorylation of the Na-K pump at Ser(938) were part of the stimulatory mechanism. These experiments were carried out in opossum kidney cells, cultured proximal tubules stably coexpressing the ANG type 1 (AT1) receptor, and either wild-type or a S938A mutant of rat kidney Na-K pump under conditions found by others to stimulate activity. We found that 10 min of incubation in 10 pM ANG II stimulated activity of wild-type pumps from 2.3 to 3.5 nmol K · mg protein(-1) · min(-1) and increased the amount of the pump in the plasma membrane by 80% but had no effect on cells expressing the S938A mutant. We conclude that acute stimulation of Na-K pump activity in native rat proximal tubules includes increased trafficking to the plasma membrane and that phosphorylation at Ser(938) is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells.

  19. A low-cost multielectrode system for data acquisition enabling real-time closed-loop processing with rapid recovery from stimulation artifacts.

    PubMed

    Rolston, John D; Gross, Robert E; Potter, Steve M

    2009-01-01

    Commercially available data acquisition systems for multielectrode recording from freely moving animals are expensive, often rely on proprietary software, and do not provide detailed, modifiable circuit schematics. When used in conjunction with electrical stimulation, they are prone to prolonged, saturating stimulation artifacts that prevent the recording of short-latency evoked responses. Yet electrical stimulation is integral to many experimental designs, and critical for emerging brain-computer interfacing and neuroprosthetic applications. To address these issues, we developed an easy-to-use, modifiable, and inexpensive system for multielectrode neural recording and stimulation. Setup costs are less than US$10,000 for 64 channels, an order of magnitude lower than comparable commercial systems. Unlike commercial equipment, the system recovers rapidly from stimulation and allows short-latency action potentials (<1 ms post-stimulus) to be detected, facilitating closed-loop applications and exposing neural activity that would otherwise remain hidden. To illustrate this capability, evoked activity from microstimulation of the rodent hippocampus is presented. System noise levels are similar to existing platforms, and extracellular action potentials and local field potentials can be recorded simultaneously. The system is modular, in banks of 16 channels, and flexible in usage: while primarily designed for in vivo use, it can be combined with commercial preamplifiers to record from in vitro multielectrode arrays. The system's open-source control software, NeuroRighter, is implemented in C#, with an easy-to-use graphical interface. As C# functions in a managed code environment, which may impact performance, analysis was conducted to ensure comparable speed to C++ for this application. Hardware schematics, layout files, and software are freely available. Since maintaining wired headstage connections with freely moving animals is difficult, we describe a new method of

  20. A Low-Cost Multielectrode System for Data Acquisition Enabling Real-Time Closed-Loop Processing with Rapid Recovery from Stimulation Artifacts

    PubMed Central

    Rolston, John D.; Gross, Robert E.; Potter, Steve M.

    2009-01-01

    Commercially available data acquisition systems for multielectrode recording from freely moving animals are expensive, often rely on proprietary software, and do not provide detailed, modifiable circuit schematics. When used in conjunction with electrical stimulation, they are prone to prolonged, saturating stimulation artifacts that prevent the recording of short-latency evoked responses. Yet electrical stimulation is integral to many experimental designs, and critical for emerging brain-computer interfacing and neuroprosthetic applications. To address these issues, we developed an easy-to-use, modifiable, and inexpensive system for multielectrode neural recording and stimulation. Setup costs are less than US$10,000 for 64 channels, an order of magnitude lower than comparable commercial systems. Unlike commercial equipment, the system recovers rapidly from stimulation and allows short-latency action potentials (<1 ms post-stimulus) to be detected, facilitating closed-loop applications and exposing neural activity that would otherwise remain hidden. To illustrate this capability, evoked activity from microstimulation of the rodent hippocampus is presented. System noise levels are similar to existing platforms, and extracellular action potentials and local field potentials can be recorded simultaneously. The system is modular, in banks of 16 channels, and flexible in usage: while primarily designed for in vivo use, it can be combined with commercial preamplifiers to record from in vitro multielectrode arrays. The system's open-source control software, NeuroRighter, is implemented in C#, with an easy-to-use graphical interface. As C# functions in a managed code environment, which may impact performance, analysis was conducted to ensure comparable speed to C++ for this application. Hardware schematics, layout files, and software are freely available. Since maintaining wired headstage connections with freely moving animals is difficult, we describe a new method of

  1. Rapid and Localized Mechanical Stimulation and Adhesion Assay: TRPM7 Involvement in Calcium Signaling and Cell Adhesion.

    PubMed

    Nishitani, Wagner Shin; Alencar, Adriano Mesquita; Wang, Yingxiao

    2015-01-01

    A cell mechanical stimulation equipment, based on cell substrate deformation, and a more sensitive method for measuring adhesion of cells were developed. A probe, precisely positioned close to the cell, was capable of a vertical localized mechanical stimulation with a temporal frequency of 207 Hz, and strain magnitude of 50%. This setup was characterized and used to probe the response of Human Umbilical Endothelial Vein Cells (HUVECs) in terms of calcium signaling. The intracellular calcium ion concentration was measured by the genetically encoded Cameleon biosensor, with the Transient Receptor Potential cation channel, subfamily M, member 7 (TRPM7) expression inhibited. As TRPM7 expression also regulates adhesion, a relatively simple method for measuring adhesion of cells was also developed, tested and used to study the effect of adhesion alone. Three adhesion conditions of HUVECs on polyacrylamide gel dishes were compared. In the first condition, the substrate is fully treated with Sulfo-SANPAH crosslinking and fibronectin. The other two conditions had increasingly reduced adhesion: partially treated (only coated with fibronectin, with no use of Sulfo-SANPAH, at 5% of the normal amount) and non-treated polyacrylamide gels. The cells showed adhesion and calcium response to the mechanical stimulation correlated to the degree of gel treatment: highest for fully treated gels and lowest for non-treated ones. TRPM7 inhibition by siRNA on HUVECs caused an increase in adhesion relative to control (no siRNA treatment) and non-targeting siRNA, but a decrease to 80% of calcium response relative to non-targeting siRNA which confirms the important role of TRPM7 in mechanotransduction despite the increase in adhesion.

  2. US ITER Moving Forward

    ScienceCinema

    US ITER / ORNL

    2016-07-12

    US ITER Project Manager Ned Sauthoff, joined by Wayne Reiersen, Team Leader Magnet Systems, and Jan Berry, Team Leader Tokamak Cooling System, discuss the U.S.'s role in the ITER international collaboration.

  3. Detection of Delta9-tetrahydrocannabinol and amphetamine-type stimulants in oral fluid using the Rapid Stat point-of-collection drug-testing device.

    PubMed

    Röhrich, J; Zörntlein, S; Becker, J; Urban, R

    2010-04-01

    The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic checks. Oral fluid and blood samples were analyzed using gas chromatography-mass spectrometry (GC-MS) for Delta(9)-tetrahydrocannabinol, amphetamine, methamphetamine, methylenedioxymethamphetamine, methylenedioxyethylamphetamine, and methylenedioxyamphetamine. The comparison of GC-MS analysis of oral fluid with the Rapid Stat results for cannabis showed a sensitivity of 85%, a specificity of 87%, and a total confirmation rate of 87%. When compared with serum, the sensitivity of the cannabis assay decreased to 71%, the specificity to 60%, and the total confirmation rate to 66%. These findings were possibly caused by an incorrect reading of the THC test results. Comparison of the Rapid Stat amphetamine assay with GC-MS in oral fluid showed a sensitivity of 94%, a specificity of 97%, and a total confirmation rate of 97%. Compared with serum, a sensitivity of 100%, a specificity of 90%, and a total confirmation rate of 92% was found. The amphetamine assay must, therefore, be regarded as satisfactory.

  4. Type 2 Iodothyronine Deiodinase Activity Is Required for Rapid Stimulation of PI3K by Thyroxine in Human Umbilical Vein Endothelial Cells.

    PubMed

    Aoki, Tomoyuki; Tsunekawa, Katsuhiko; Araki, Osamu; Ogiwara, Takayuki; Nara, Makoto; Sumino, Hiroyuki; Kimura, Takao; Murakami, Masami

    2015-11-01

    Thyroid hormones (THs) exert a number of physiological effects on the cardiovascular system. Some of the nongenomic actions of T3 are achieved by cross coupling the TH receptor (TR) with the phosphatidylinositol 3-kinase (PI3K)/protein kinase Akt (Akt) pathway. We observed that both T3 and T4 rapidly stimulated Akt phosphorylation and Ras-related C3 botulinum toxin substrate 1 (Rac1) activation, which resulted in cell migration, in a PI3K-dependent manner in human umbilical vein endothelial cells (HUVECs). We identified the expression of type 2 iodothyronine deiodinase (D2), which converts T4 to T3, and TRα1 in HUVECs. D2 activity was significantly stimulated by (Bu)2cAMP in HUVECs. The blockade of D2 activity through transfection of small interfering RNA (siRNA) specific to D2 as well as by addition of iopanoic acid, a potent D2 inhibitor, abolished Akt phosphorylation, Rac activation, and cell migration induced by T4 but not by T3. The inhibition of TRα1 expression by the transfection of siRNA for TRα1 canceled Akt phosphorylation, Rac activation, and cell migration induced by T3 and T4. These findings suggest that conversion of T4 to T3 by D2 is required for TRα1/PI3K-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt phosphorylation and Rac activation, which result in cell migration. PMID:26284425

  5. ITER test programme

    NASA Astrophysics Data System (ADS)

    Abdou, M.; Baker, C.; Casini, G.

    1991-07-01

    The International Thermonuclear Experimental Reactor (ITER) was designed to operate in two phases. The first phase, which lasts for 6 years, is devoted to machine checkout and physics testing. The second phase lasts for 8 years and is devoted primarily to technology testing. This report describes the technology test program development for ITER, the ancillary equipment outside the torus necessary to support the test modules, the international collaboration aspects of conducting the test program on ITER, the requirements on the machine major parameters and the R and D program required to develop the test modules for testing in ITER.

  6. Iteration, Not Induction

    ERIC Educational Resources Information Center

    Dobbs, David E.

    2009-01-01

    The main purpose of this note is to present and justify proof via iteration as an intuitive, creative and empowering method that is often available and preferable as an alternative to proofs via either mathematical induction or the well-ordering principle. The method of iteration depends only on the fact that any strictly decreasing sequence of…

  7. Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart

    PubMed Central

    Vielma, Alejandra Z.; León, Luisa; Fernández, Ignacio C.; González, Daniel R.

    2016-01-01

    S-nitrosylation of several Ca2+ regulating proteins in response to β-adrenergic stimulation was recently described in the heart; however the specific nitric oxide synthase (NOS) isoform and signaling pathways responsible for this modification have not been elucidated. NOS-1 activity increases inotropism, therefore, we tested whether β-adrenergic stimulation induces NOS-1-dependent S-nitrosylation of total proteins, the ryanodine receptor (RyR2), SERCA2 and the L-Type Ca2+ channel (LTCC). In the isolated rat heart, isoproterenol (10 nM, 3-min) increased S-nitrosylation of total cardiac proteins (+46±14%) and RyR2 (+146±77%), without affecting S-nitrosylation of SERCA2 and LTCC. Selective NOS-1 blockade with S-methyl-L-thiocitrulline (SMTC) and Nω-propyl-l-arginine decreased basal contractility and relaxation (−25–30%) and basal S-nitrosylation of total proteins (−25–60%), RyR2, SERCA2 and LTCC (−60–75%). NOS-1 inhibition reduced (−25–40%) the inotropic response and protein S-nitrosylation induced by isoproterenol, particularly that of RyR2 (−85±7%). Tempol, a superoxide scavenger, mimicked the effects of NOS-1 inhibition on inotropism and protein S-nitrosylation; whereas selective NOS-3 inhibitor L-N5-(1-Iminoethyl)ornithine had no effect. Inhibition of NOS-1 did not affect phospholamban phosphorylation, but reduced its oligomerization. Attenuation of contractility was abolished by PKA blockade and unaffected by guanylate cyclase inhibition. Additionally, in isolated mouse cardiomyocytes, NOS-1 inhibition or removal reduced the Ca2+-transient amplitude and sarcomere shortening induced by isoproterenol or by direct PKA activation. We conclude that 1) normal cardiac performance requires basal NOS-1 activity and S-nitrosylation of the calcium-cycling machinery; 2) β-adrenergic stimulation induces rapid and reversible NOS-1 dependent, PKA and ROS-dependent, S-nitrosylation of RyR2 and other proteins, accounting for about one third of its

  8. Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart.

    PubMed

    Vielma, Alejandra Z; León, Luisa; Fernández, Ignacio C; González, Daniel R; Boric, Mauricio P

    2016-01-01

    S-nitrosylation of several Ca2+ regulating proteins in response to β-adrenergic stimulation was recently described in the heart; however the specific nitric oxide synthase (NOS) isoform and signaling pathways responsible for this modification have not been elucidated. NOS-1 activity increases inotropism, therefore, we tested whether β-adrenergic stimulation induces NOS-1-dependent S-nitrosylation of total proteins, the ryanodine receptor (RyR2), SERCA2 and the L-Type Ca2+ channel (LTCC). In the isolated rat heart, isoproterenol (10 nM, 3-min) increased S-nitrosylation of total cardiac proteins (+46±14%) and RyR2 (+146±77%), without affecting S-nitrosylation of SERCA2 and LTCC. Selective NOS-1 blockade with S-methyl-L-thiocitrulline (SMTC) and Nω-propyl-l-arginine decreased basal contractility and relaxation (-25-30%) and basal S-nitrosylation of total proteins (-25-60%), RyR2, SERCA2 and LTCC (-60-75%). NOS-1 inhibition reduced (-25-40%) the inotropic response and protein S-nitrosylation induced by isoproterenol, particularly that of RyR2 (-85±7%). Tempol, a superoxide scavenger, mimicked the effects of NOS-1 inhibition on inotropism and protein S-nitrosylation; whereas selective NOS-3 inhibitor L-N5-(1-Iminoethyl)ornithine had no effect. Inhibition of NOS-1 did not affect phospholamban phosphorylation, but reduced its oligomerization. Attenuation of contractility was abolished by PKA blockade and unaffected by guanylate cyclase inhibition. Additionally, in isolated mouse cardiomyocytes, NOS-1 inhibition or removal reduced the Ca2+-transient amplitude and sarcomere shortening induced by isoproterenol or by direct PKA activation. We conclude that 1) normal cardiac performance requires basal NOS-1 activity and S-nitrosylation of the calcium-cycling machinery; 2) β-adrenergic stimulation induces rapid and reversible NOS-1 dependent, PKA and ROS-dependent, S-nitrosylation of RyR2 and other proteins, accounting for about one third of its inotropic effect.

  9. Bradykinin-stimulated inositol phosphate production in NG108-15 cells is mediated by a small population of binding sites which rapidly desensitize.

    PubMed

    Wolsing, D H; Rosenbaum, J S

    1991-05-01

    [3H]Bradykinin (BDK) binds to two distinct binding sites (P less than .01, N = 12) in NG108-15 cell membranes; (site 1: Kd1 = 3.09 x 10(-10) M, Bmax1 = 242 +/- 24 fmol/mg protein) and (site 2: Kd2 = 1.94 x 10(-8) M, Bmax2 = 491 +/- 75 fmol/mg protein). Although site 1 comprises only 33 +/- 4% (N = 12) of the total binding site population, comparison of the binding affinity and functional potency for BDK agonist analogs exhibiting differential selectivity for the two sites reveals that this high affinity site is the receptor mediating inositol monophosphate (IP) production in this cell line. BDK-stimulated IP production undergoes a very rapid (5 min) desensitization that is characterized by both a loss in agonist potency (EC50 = 3.57 x 10(-9) M vs. 1.94 x 10(-10) M in controls; P less than .001, N = 12) and a decrease in amplitude of response (fold stimulation = 1.45 +/- 0.06 vs. 1.80 +/- 0.09 in controls; P less than .01, N = 12). Only the decrease in response amplitude is attenuated by down-regulation of protein kinase C by prior long term treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate (TPA), indicating an involvement of protein kinase C activation in the desensitization process. Desensitization is accompanied by down-regulation of site 1 only (Bmax1 = 71 +/- 8 fmol/mg (N = 10; P less than .001 vs. controls)); Bmax2 and the Kd for BDK at both sites remain unchanged, further supporting the contention that site 1 is the functionally relevant receptor. In contrast to the functional data, long term TPA treatment does not attenuate the receptor down-regulation, indicating that the rapid desensitization involves both receptor-related and postreceptor mechanisms. The implications of this property of the BDK receptor for analog design and receptor classification are discussed.

  10. Perl Modules for Constructing Iterators

    NASA Technical Reports Server (NTRS)

    Tilmes, Curt

    2009-01-01

    The Iterator Perl Module provides a general-purpose framework for constructing iterator objects within Perl, and a standard API for interacting with those objects. Iterators are an object-oriented design pattern where a description of a series of values is used in a constructor. Subsequent queries can request values in that series. These Perl modules build on the standard Iterator framework and provide iterators for some other types of values. Iterator::DateTime constructs iterators from DateTime objects or Date::Parse descriptions and ICal/RFC 2445 style re-currence descriptions. It supports a variety of input parameters, including a start to the sequence, an end to the sequence, an Ical/RFC 2445 recurrence describing the frequency of the values in the series, and a format description that can refine the presentation manner of the DateTime. Iterator::String constructs iterators from string representations. This module is useful in contexts where the API consists of supplying a string and getting back an iterator where the specific iteration desired is opaque to the caller. It is of particular value to the Iterator::Hash module which provides nested iterations. Iterator::Hash constructs iterators from Perl hashes that can include multiple iterators. The constructed iterators will return all the permutations of the iterations of the hash by nested iteration of embedded iterators. A hash simply includes a set of keys mapped to values. It is a very common data structure used throughout Perl programming. The Iterator:: Hash module allows a hash to include strings defining iterators (parsed and dispatched with Iterator::String) that are used to construct an overall series of hash values.

  11. Diagnostics for ITER

    SciTech Connect

    Donne, A. J. H.; Hellermann, M. G. von; Barnsley, R.

    2008-10-22

    After an introduction into the specific challenges in the field of diagnostics for ITER (specifically high level of nuclear radiation, long pulses, high fluxes of particles to plasma facing components, need for reliability and robustness), an overview will be given of the spectroscopic diagnostics foreseen for ITER. The paper will describe both active neutral-beam based diagnostics as well as passive spectroscopic diagnostics operating in the visible, ultra-violet and x-ray spectral regions.

  12. ITER convertible blanket evaluation

    SciTech Connect

    Wong, C.P.C.; Cheng, E.

    1995-09-01

    Proposed International Thermonuclear Experimental Reactor (ITER) convertible blankets were reviewed. Key design difficulties were identified. A new particle filter concept is introduced and key performance parameters estimated. Results show that this particle filter concept can satisfy all of the convertible blanket design requirements except the generic issue of Be blanket lifetime. If the convertible blanket is an acceptable approach for ITER operation, this particle filter option should be a strong candidate.

  13. Fusion Physics Toward ITER

    NASA Astrophysics Data System (ADS)

    Stambaugh, R. D.

    2006-04-01

    Stars are powered by fusion, the energy released by fusing together light nuclei, using gravitational confinement of plasma. Fusion on earth will be done in a 100 million degree plasma made of deuterium and tritium and confined by magnetic fields or inertia. The worldwide fusion research community will construct ITER, the first experiment that will burn a DT plasma by copious fusion reactions. ITER's nominal goal is to create 500 MW of fusion power. An energy gain of 10 will mean the plasma is dominantly self-heated by the fusion-produced alpha particles. ITER's all superconducting magnet technology and steady-state heat removal technology will enable nominal 400 s pulses to allow the study of burning plasmas on the longest intrinsic timescale of the confined plasma - diffusive redistribution of the electrical currents in the plasma. The advances in magnetic confinement physics that have led to this opportunity will be described, as well as the research opportunities afforded by ITER. The physics of confining stable plasmas and heating them will produce the high gain state in ITER. Sustained burn will come from the physics of controlling currents in plasmas and how the hot plasma is interfaced to its room temperature surroundings. ITER will provide our first experience with how fusion plasma self-heating will profoundly affect the complex, interlinked physical processes that occur in confined plasmas.

  14. Toward Construction of ITER

    NASA Astrophysics Data System (ADS)

    Shimomura, Yasuo

    The ITER Project has been significantly developed in the past years in preparation for its construction. The ITER Negotiators have developed a draft Joint Implementation Agreement (JIA), ready for completion following the nomination of the Project’s Director General (DG). The ITER International Team and Participant Teams have continued technical and organizational preparations. The actual construction will be able to start immediately after the international ITER organization will be established, following signature of the JIA. The Project is now strongly supported by all the participants as well as by the scientific community with the final high-level negotiations, focused on siting and the concluding details of cost sharing, started in December 2003. The EU, with Cadarache, and Japan, with Rokkasho, have both promised large contributions to the project to strongly support their construction site proposals. The extent to which they both wish to host the ITER facility is such that large contributions to a broader collaboration among the Parties are also proposed by them. This covers complementary activities to help accelerate fusion development towards a viable power source, as well as may allow the Participants to reach a conclusion on ITER siting.

  15. Lanczos iterated time-reversal.

    PubMed

    Oberai, Assad A; Feijóo, Gonzalo R; Barbone, Paul E

    2009-02-01

    A new iterative time-reversal algorithm capable of identifying and focusing on multiple scatterers in a relatively small number of iterations is developed. It is recognized that the traditional iterated time-reversal method is based on utilizing power iterations to determine the dominant eigenpairs of the time-reversal operator. The convergence properties of these iterations are known to be suboptimal. Motivated by this, a new method based on Lanczos iterations is developed. In several illustrative examples it is demonstrated that for the same number of transmitted and received signals, the Lanczos iterations based approach is substantially more accurate. PMID:19206835

  16. Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

    PubMed

    Teng, Yun; Radde, Brandie N; Litchfield, Lacey M; Ivanova, Margarita M; Prough, Russell A; Clark, Barbara J; Doll, Mark A; Hein, David W; Klinge, Carolyn M

    2015-06-19

    Little is known about the regulation of the oncomiR miR-21 in liver. Dehydroepiandrosterone (DHEA) regulates gene expression as a ligand for a G-protein-coupled receptor and as a precursor for steroids that activate nuclear receptor signaling. We report that 10 nm DHEA increases primary miR-21 (pri-miR-21) transcription and mature miR-21 expression in HepG2 cells in a biphasic manner with an initial peak at 1 h followed by a second, sustained response from 3-12 h. DHEA also increased miR-21 in primary human hepatocytes and Hep3B cells. siRNA, antibody, and inhibitor studies suggest that the rapid DHEA-mediated increase in miR-21 involves a G-protein-coupled estrogen receptor (GPER/GPR30), estrogen receptor α-36 (ERα36), epidermal growth factor receptor-dependent, pertussis toxin-sensitive pathway requiring activation of c-Src, ERK1/2, and PI3K. GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription. Like DHEA, GPER agonists G-1 and fulvestrant increased pri-miR-21 in a GPER- and ERα36-dependent manner. DHEA, like G-1, increased GPER and ERα36 mRNA and protein levels. DHEA increased ERK1/2 and c-Src phosphorylation in a GPER-responsive manner. DHEA increased c-Jun, but not c-Fos, protein expression after 2 h. DHEA increased androgen receptor, c-Fos, and c-Jun recruitment to the miR-21 promoter. These results suggest that physiological concentrations of DHEA activate a GPER intracellular signaling cascade that increases pri-miR-21 transcription mediated at least in part by AP-1 and androgen receptor miR-21 promoter interaction.

  17. Rescheduling with iterative repair

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Davis, Eugene; Daun, Brian; Deale, Michael

    1992-01-01

    This paper presents a new approach to rescheduling called constraint-based iterative repair. This approach gives our system the ability to satisfy domain constraints, address optimization concerns, minimize perturbation to the original schedule, produce modified schedules, quickly, and exhibits 'anytime' behavior. The system begins with an initial, flawed schedule and then iteratively repairs constraint violations until a conflict-free schedule is produced. In an empirical demonstration, we vary the importance of minimizing perturbation and report how fast the system is able to resolve conflicts in a given time bound. We also show the anytime characteristics of the system. These experiments were performed within the domain of Space Shuttle ground processing.

  18. ITER Fusion Energy

    ScienceCinema

    Dr. Norbert Holtkamp

    2016-07-12

    ITER (in Latin “the way”) is designed to demonstrate the scientific and technological feasibility of fusion energy. Fusion is the process by which two light atomic nuclei combine to form a heavier over one and thus release energy. In the fusion process two isotopes of hydrogen – deuterium and tritium – fuse together to form a helium atom and a neutron. Thus fusion could provide large scale energy production without greenhouse effects; essentially limitless fuel would be available all over the world. The principal goals of ITER are to generate 500 megawatts of fusion power for periods of 300 to 500 seconds with a fusion power multiplication factor, Q, of at least 10. Q ? 10 (input power 50 MW / output power 500 MW). The ITER Organization was officially established in Cadarache, France, on 24 October 2007. The seven members engaged in the project – China, the European Union, India, Japan, Korea, Russia and the United States – represent more than half the world’s population. The costs for ITER are shared by the seven members. The cost for the construction will be approximately 5.5 billion Euros, a similar amount is foreseen for the twenty-year phase of operation and the subsequent decommissioning.

  19. An Iterative Angle Trisection

    ERIC Educational Resources Information Center

    Muench, Donald L.

    2007-01-01

    The problem of angle trisection continues to fascinate people even though it has long been known that it can't be done with straightedge and compass alone. However, for practical purposes, a good iterative procedure can get you as close as you want. In this note, we present such a procedure. Using only straightedge and compass, our procedure…

  20. Iterative software kernels

    SciTech Connect

    Duff, I.

    1994-12-31

    This workshop focuses on kernels for iterative software packages. Specifically, the three speakers discuss various aspects of sparse BLAS kernels. Their topics are: `Current status of user lever sparse BLAS`; Current status of the sparse BLAS toolkit`; and `Adding matrix-matrix and matrix-matrix-matrix multiply to the sparse BLAS toolkit`.

  1. ITER global stability limits

    SciTech Connect

    Hogan, J.T.; Uckan, N.A.

    1990-01-01

    The MHD stability limits to the ITER operational space have been examined with the PEST ideal stability code. Constraints on ITER operation have been examined for the nominal operational scenarios and for possible design variants. Rather than rely on evaluation of a relatively small number of sample cases, the approach has been to construct an approximation to the overall operational space, and to compare this with the observed limits in high-{beta} tokamaks. An extensive database with {approximately}20,000 stability results has been compiled for use by the ITER design team. Results from these studies show that the design values of the Troyon factor (g {approximately} 2.5 for ignition studies, and g {approximately} 3 for the technology phase) which are based on present experiments, are also expected to be attainable for ITER conditions, for which the configuration and wall-stabilisation environment differ from those in present experiments. Strongly peaked pressure profiles lead to degraded high-{beta} performance. Values of g {approximately} 4 are found for higher safety factor (q {sub {Psi}} {le} 4) than that of the present design (q{sub {Psi}} {approximately} 3). Profiles with q(0) < 1 are shown to give g {approximately} 2.5, if the current density profile provides optimum shear. The overall operational spaces are presented for g-q{sub {Psi}}, q{sub {Psi}}-1{sub i}, q-{alpha}{sub p} and l{sub i}-q{sub {psi}}.

  2. Neutron activation for ITER

    SciTech Connect

    Barnes, C.W.; Loughlin, M.J.; Nishitani, Takeo

    1996-04-29

    There are three primary goals for the Neutron Activation system for ITER: maintain a robust relative measure of fusion power with stability and high dynamic range (7 orders of magnitude); allow an absolute calibration of fusion power (energy); and provide a flexible and reliable system for materials testing. The nature of the activation technique is such that stability and high dynamic range can be intrinsic properties of the system. It has also been the technique that demonstrated (on JET and TFTR) the highest accuracy neutron measurements in DT operation. Since the gamma-ray detectors are not located on the tokamak and are therefore amenable to accurate characterization, and if material foils are placed very close to the ITER plasma with minimum scattering or attenuation, high overall accuracy in the fusion energy production (7--10%) should be achievable on ITER. In the paper, a conceptual design is presented. A system is shown to be capable of meeting these three goals, also detailed design issues remain to be solved.

  3. Adaptive iterative reconstruction

    NASA Astrophysics Data System (ADS)

    Bruder, H.; Raupach, R.; Sunnegardh, J.; Sedlmair, M.; Stierstorfer, K.; Flohr, T.

    2011-03-01

    It is well known that, in CT reconstruction, Maximum A Posteriori (MAP) reconstruction based on a Poisson noise model can be well approximated by Penalized Weighted Least Square (PWLS) minimization based on a data dependent Gaussian noise model. We study minimization of the PWLS objective function using the Gradient Descent (GD) method, and show that if an exact inverse of the forward projector exists, the PWLS GD update equation can be translated into an update equation which entirely operates in the image domain. In case of non-linear regularization and arbitrary noise model this means that a non-linear image filter must exist which solves the optimization problem. In the general case of non-linear regularization and arbitrary noise model, the analytical computation is not trivial and might lead to image filters which are computationally very expensive. We introduce a new iteration scheme in image space, based on a regularization filter with an anisotropic noise model. Basically, this approximates the statistical data weighting and regularization in PWLS reconstruction. If needed, e.g. for compensation of the non-exactness of backprojector, the image-based regularization loop can be preceded by a raw data based loop without regularization and statistical data weighting. We call this combined iterative reconstruction scheme Adaptive Iterative Reconstruction (AIR). It will be shown that in terms of low-contrast visibility, sharpness-to-noise and contrast-to-noise ratio, PWLS and AIR reconstruction are similar to a high degree of accuracy. In clinical images the noise texture of AIR is also superior to the more artificial texture of PWLS.

  4. Quantum iterated function systems.

    PubMed

    Łoziński, Artur; Zyczkowski, Karol; Słomczyński, Wojciech

    2003-10-01

    An iterated function system (IFS) is defined by specifying a set of functions in a classical phase space, which act randomly on an initial point. In an analogous way, we define a quantum IFS (QIFS), where functions act randomly with prescribed probabilities in the Hilbert space. In a more general setting, a QIFS consists of completely positive maps acting in the space of density operators. This formalism is designed to describe certain problems of nonunitary quantum dynamics. We present exemplary classical IFSs, the invariant measure of which exhibits fractal structure, and study properties of the corresponding QIFSs and their invariant states.

  5. Iterative Magnetometer Calibration

    NASA Technical Reports Server (NTRS)

    Sedlak, Joseph

    2006-01-01

    This paper presents an iterative method for three-axis magnetometer (TAM) calibration that makes use of three existing utilities recently incorporated into the attitude ground support system used at NASA's Goddard Space Flight Center. The method combines attitude-independent and attitude-dependent calibration algorithms with a new spinning spacecraft Kalman filter to solve for biases, scale factors, nonorthogonal corrections to the alignment, and the orthogonal sensor alignment. The method is particularly well-suited to spin-stabilized spacecraft, but may also be useful for three-axis stabilized missions given sufficient data to provide observability.

  6. MLP iterative construction algorithm

    NASA Astrophysics Data System (ADS)

    Rathbun, Thomas F.; Rogers, Steven K.; DeSimio, Martin P.; Oxley, Mark E.

    1997-04-01

    The MLP Iterative Construction Algorithm (MICA) designs a Multi-Layer Perceptron (MLP) neural network as it trains. MICA adds Hidden Layer Nodes one at a time, separating classes on a pair-wise basis, until the data is projected into a linear separable space by class. Then MICA trains the Output Layer Nodes, which results in an MLP that achieves 100% accuracy on the training data. MICA, like Backprop, produces an MLP that is a minimum mean squared error approximation of the Bayes optimal discriminant function. Moreover, MICA's training technique yields novel feature selection technique and hidden node pruning technique

  7. Weighted iterative reconstruction for magnetic particle imaging

    NASA Astrophysics Data System (ADS)

    Knopp, T.; Rahmer, J.; Sattel, T. F.; Biederer, S.; Weizenecker, J.; Gleich, B.; Borgert, J.; Buzug, T. M.

    2010-03-01

    Magnetic particle imaging (MPI) is a new imaging technique capable of imaging the distribution of superparamagnetic particles at high spatial and temporal resolution. For the reconstruction of the particle distribution, a system of linear equations has to be solved. The mathematical solution to this linear system can be obtained using a least-squares approach. In this paper, it is shown that the quality of the least-squares solution can be improved by incorporating a weighting matrix using the reciprocal of the matrix-row energy as weights. A further benefit of this weighting is that iterative algorithms, such as the conjugate gradient method, converge rapidly yielding the same image quality as obtained by singular value decomposition in only a few iterations. Thus, the weighting strategy in combination with the conjugate gradient method improves the image quality and substantially shortens the reconstruction time. The performance of weighting strategy and reconstruction algorithms is assessed with experimental data of a 2D MPI scanner.

  8. Recent ADI iteration analysis and results

    SciTech Connect

    Wachspress, E.L.

    1994-12-31

    Some recent ADI iteration analysis and results are discussed. Discovery that the Lyapunov and Sylvester matrix equations are model ADI problems stimulated much research on ADI iteration with complex spectra. The ADI rational Chebyshev analysis parallels the classical linear Chebyshev theory. Two distinct approaches have been applied to these problems. First, parameters which were optimal for real spectra were shown to be nearly optimal for certain families of complex spectra. In the linear case these were spectra bounded by ellipses in the complex plane. In the ADI rational case these were spectra bounded by {open_quotes}elliptic-function regions{close_quotes}. The logarithms of the latter appear like ellipses, and the logarithms of the optimal ADI parameters for these regions are similar to the optimal parameters for linear Chebyshev approximation over superimposed ellipses. W.B. Jordan`s bilinear transformation of real variables to reduce the two-variable problem to one variable was generalized into the complex plane. This was needed for ADI iterative solution of the Sylvester equation.

  9. ECRH System For ITER

    SciTech Connect

    Darbos, C.; Henderson, M.; Gandini, F.; Albajar, F.; Bomcelli, T.; Heidinger, R.; Saibene, G.; Chavan, R.; Goodman, T.; Hogge, J. P.; Sauter, O.; Denisov, G.; Farina, D.; Kajiwara, K.; Kasugai, A.; Kobayashi, N.; Oda, Y.; Ramponi, G.

    2009-11-26

    A 26 MW Electron Cyclotron Heating and Current Drive (EC H and CD) system is to be installed for ITER. The main objectives are to provide, start-up assist, central H and CD and control of MHD activity. These are achieved by a combination of two types of launchers, one located in an equatorial port and the second type in four upper ports. The physics applications are partitioned between the two launchers, based on the deposition location and driven current profiles. The equatorial launcher (EL) will access from the plasma axis to mid radius with a relatively broad profile useful for central heating and current drive applications, while the upper launchers (ULs) will access roughly the outer half of the plasma radius with a very narrow peaked profile for the control of the Neoclassical Tearing Modes (NTM) and sawtooth oscillations. The EC power can be switched between launchers on a time scale as needed by the immediate physics requirements. A revision of all injection angles of all launchers is under consideration for increased EC physics capabilities while relaxing the engineering constraints of both the EL and ULs. A series of design reviews are being planned with the five parties (EU, IN, JA, RF, US) procuring the EC system, the EC community and ITER Organization (IO). The review meetings qualify the design and provide an environment for enhancing performances while reducing costs, simplifying interfaces, predicting technology upgrades and commercial availability. In parallel, the test programs for critical components are being supported by IO and performed by the Domestic Agencies (DAs) for minimizing risks. The wide participation of the DAs provides a broad representation from the EC community, with the aim of collecting all expertise in guiding the EC system optimization. Still a strong relationship between IO and the DA is essential for optimizing the design of the EC system and for the installation and commissioning of all ex-vessel components when several

  10. Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells.

    PubMed Central

    Häring, H U; White, M F; Machicao, F; Ermel, B; Schleicher, E; Obermaier, B

    1987-01-01

    It is speculated that the transmission of an insulin signal across the plasma membrane of cells occurs through activation of the tyrosine-specific receptor kinase, autophosphorylation of the receptor, and subsequent phosphorylation of unidentified substrates in the cell. In an attempt to identify possible substrates, we labeled intact rat fat cells with [32P]orthophosphate and used an antiphosphotyrosine antibody to identify proteins that become phosphorylated on tyrosine residues in an insulin-stimulated way. In the membrane fraction of the fat cells, we found, in addition to the 95-kDa beta-subunit of the receptor, a 46-kDa phosphoprotein that is phosphorylated exclusively on tyrosine residues. This protein is not immunoprecipitated by antibodies against different regions of the insulin receptor and its HPLC tryptic peptide map is different from the tryptic peptide map of the insulin receptor, suggesting that it is not derived from the receptor beta-subunit. Insulin stimulates the tyrosine phosphorylation of the 46-kDa protein within 150 sec in the intact cell 3- to 4-fold in a dose-dependent way at insulin concentrations between 0.5 nM and 100 nM. The insulin effect starts after 30 sec, is maximal at 150 sec, and declines to almost basal values by 5 min. Furthermore, the antiphosphotyrosine antibody precipitated at least five proteins in the soluble fraction of the fat cell. Insulin (0.5 nM, 100 nM) stimulated within 2 min the 32P incorporation into a 116-kDa band, a 62-kDa band, and three bands between 45 kDa and 50 kDa 2- to 10-fold. We suggest that the 46-kDa membrane protein and possibly also the soluble proteins are endogenous substrates of the receptor tyrosine kinase in fat cells and that their phosphorylation is an early step in insulin signal transmission. Images PMID:3540953

  11. Iterated crowdsourcing dilemma game

    NASA Astrophysics Data System (ADS)

    Oishi, Koji; Cebrian, Manuel; Abeliuk, Andres; Masuda, Naoki

    2014-02-01

    The Internet has enabled the emergence of collective problem solving, also known as crowdsourcing, as a viable option for solving complex tasks. However, the openness of crowdsourcing presents a challenge because solutions obtained by it can be sabotaged, stolen, and manipulated at a low cost for the attacker. We extend a previously proposed crowdsourcing dilemma game to an iterated game to address this question. We enumerate pure evolutionarily stable strategies within the class of so-called reactive strategies, i.e., those depending on the last action of the opponent. Among the 4096 possible reactive strategies, we find 16 strategies each of which is stable in some parameter regions. Repeated encounters of the players can improve social welfare when the damage inflicted by an attack and the cost of attack are both small. Under the current framework, repeated interactions do not really ameliorate the crowdsourcing dilemma in a majority of the parameter space.

  12. Mission of ITER and Challenges for the Young

    SciTech Connect

    Ikeda, Kaname

    2009-02-19

    It is recognized that the ongoing effort to provide sufficient energy for the wellbeing of the globe's population and to power the world economy is of the greatest importance. ITER is a joint international research and development project that aims to demonstrate the scientific and technical feasibility of fusion power. It represents the responsible actions of governments whose countries comprise over half the world's population, to create fusion power as a source of clean, economic, carbon dioxide-free energy. This is the most important science initiative of our time.The partners in the Project--the ITER Parties--are the European Union, Japan, the People's Republic of China, India, the Republic of Korea, the Russian Federation and the USA. ITER will be constructed in Europe, at Cadarache in the South of France. The talk will illustrate the genesis of the ITER Organization, the ongoing work at the Cadarache site and the planned schedule for construction. There will also be an explanation of the unique aspects of international collaboration that have been developed for ITER.Although the present focus of the project is construction activities, ITER is also a major scientific and technological research program, for which the best of the world's intellectual resources is needed. Challenges for the young, imperative for fulfillment of the objective of ITER will be identified. It is important that young students and researchers worldwide recognize the rapid development of the project, and the fundamental issues that must be overcome in ITER.The talk will also cover the exciting career and fellowship opportunities for young people at the ITER Organization.

  13. Mission of ITER and Challenges for the Young

    NASA Astrophysics Data System (ADS)

    Ikeda, Kaname

    2009-02-01

    It is recognized that the ongoing effort to provide sufficient energy for the wellbeing of the globe's population and to power the world economy is of the greatest importance. ITER is a joint international research and development project that aims to demonstrate the scientific and technical feasibility of fusion power. It represents the responsible actions of governments whose countries comprise over half the world's population, to create fusion power as a source of clean, economic, carbon dioxide-free energy. This is the most important science initiative of our time. The partners in the Project—the ITER Parties—are the European Union, Japan, the People's Republic of China, India, the Republic of Korea, the Russian Federation and the USA. ITER will be constructed in Europe, at Cadarache in the South of France. The talk will illustrate the genesis of the ITER Organization, the ongoing work at the Cadarache site and the planned schedule for construction. There will also be an explanation of the unique aspects of international collaboration that have been developed for ITER. Although the present focus of the project is construction activities, ITER is also a major scientific and technological research program, for which the best of the world's intellectual resources is needed. Challenges for the young, imperative for fulfillment of the objective of ITER will be identified. It is important that young students and researchers worldwide recognize the rapid development of the project, and the fundamental issues that must be overcome in ITER. The talk will also cover the exciting career and fellowship opportunities for young people at the ITER Organization.

  14. 3D printing of soft lithography mold for rapid production of polydimethylsiloxane-based microfluidic devices for cell stimulation with concentration gradients.

    PubMed

    Kamei, Ken-ichiro; Mashimo, Yasumasa; Koyama, Yoshie; Fockenberg, Christopher; Nakashima, Miyuki; Nakajima, Minako; Li, Junjun; Chen, Yong

    2015-04-01

    Three-dimensional (3D) printing is advantageous over conventional technologies for the fabrication of sophisticated structures such as 3D micro-channels for future applications in tissue engineering and drug screening. We aimed to apply this technology to cell-based assays using polydimethylsiloxane (PDMS), the most commonly used material for fabrication of micro-channels used for cell culture experiments. Useful properties of PDMS include biocompatibility, gas permeability and transparency. We developed a simple and robust protocol to generate PDMS-based devices using a soft lithography mold produced by 3D printing. 3D chemical gradients were then generated to stimulate cells confined to a micro-channel. We demonstrate that concentration gradients of growth factors, important regulators of cell/tissue functions in vivo, influence the survival and growth of human embryonic stem cells. Thus, this approach for generation of 3D concentration gradients could have strong implications for tissue engineering and drug screening.

  15. IL-22 is rapidly induced by Pathogen Recognition Receptors Stimulation in Bone-Marrow-derived Dendritic Cells in the Absence of IL-23

    PubMed Central

    Fumagalli, Silvia; Torri, Anna; Papagna, Angela; Citterio, Stefania; Mainoldi, Federica; Foti, Maria

    2016-01-01

    In vertebrates, microorganisms are recognized by pathogen recognition receptors (PRRs). Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of genes. Within these genes, the cytokines family plays a crucial function because of its role in adaptive immunity induction and in tissue-specific functional regulation, such as tissue repair and tissue homeostasis during steady state conditions. Within the myeloid compartment, dendritic cells (DCs) release a variety of inflammatory cytokines in response to microbes. In this study, we show that BMDCs release IL-22 directly upon PRRs activation without the need of IL-23 signaling as reported for other IL22-producing cells. Moreover, we demonstrate that cytokine IL-22 is rapidly released in a cell-specific manner as macrophages are not able to produce IL-22 through the same PRRs system. In addition, we characterize the intracellular signaling cascade required for IL-22 release in BMDCs. Myd88, MEK1/2, NFkb and AhR, but not p38, NFAT, and RORgt, were found to be involved in IL-22 regulation in DCs. Our study suggests that BMDCs possess a unique intracellular molecular plasticity which, once activated, directs different BMDCs functions in a cell-specific manner. PMID:27652524

  16. ITER Diagnostic First Wal

    SciTech Connect

    G. Douglas Loesser, et. al.

    2012-09-21

    The ITER Diagnostic Division is responsible for designing and procuring the First Wall Blankets that are mounted on the vacuum vessel port plugs at both the upper and equatorial levels This paper will discuss the effects of the diagnostic aperture shape and configuration on the coolant circuit design. The DFW design is driven in large part by the need to conform the coolant arrangement to a wide variety of diagnostic apertures combined with the more severe heating conditions at the surface facing the plasma, the first wall. At the first wall, a radiant heat flux of 35W/cm2 combines with approximate peak volumetric heating rates of 8W/cm3 (equatorial ports) and 5W/cm3 (upper ports). Here at the FW, a fast thermal response is desirable and leads to a thin element between the heat flux and coolant. This requirement is opposed by the wish for a thicker FW element to accommodate surface erosion and other off-normal plasma events.

  17. Mode conversion in ITER

    NASA Astrophysics Data System (ADS)

    Jaeger, E. F.; Berry, L. A.; Myra, J. R.

    2006-10-01

    Fast magnetosonic waves in the ion cyclotron range of frequencies (ICRF) can convert to much shorter wavelength modes such as ion Bernstein waves (IBW) and ion cyclotron waves (ICW) [1]. These modes are potentially useful for plasma control through the generation of localized currents and sheared flows. As part of the SciDAC Center for Simulation of Wave-Plasma Interactions project, the AORSA global-wave solver [2] has been ported to the new, dual-core Cray XT-3 (Jaguar) at ORNL where it demonstrates excellent scaling with the number of processors. Preliminary calculations using 4096 processors have allowed the first full-wave simulations of mode conversion in ITER. Mode conversion from the fast wave to the ICW is observed in mixtures of deuterium, tritium and helium3 at 53 MHz. The resulting flow velocity and electric field shear will be calculated. [1] F.W. Perkins, Nucl. Fusion 17, 1197 (1977). [2] E.F. Jaeger, L.A. Berry, J.R. Myra, et al., Phys. Rev. Lett. 90, 195001-1 (2003).

  18. Simple solution for preventing cerebrospinal fluid loss and brain shift during multitrack deep brain stimulation surgery in the semisupine position: polyethylene glycol hydrogel dural sealant capping: rapid communication.

    PubMed

    Takumi, Ichiro; Mishina, Masahiro; Hironaka, Kohei; Oyama, Kenichi; Yamada, Akira; Adachi, Koji; Hamamoto, Makoto; Kitamura, Shin; Yoshida, Daizo; Teramoto, Akira

    2013-01-01

    This study evaluated preliminary findings on the efficacy of polyethylene glycol (PEG) hydrogel dural sealant capping for the prevention of cerebrospinal fluid (CSF) leakage and pneumocephalus during deep brain stimulation (DBS) surgery in the semisupine position. Group A consisted of 5 patients who underwent bilateral subthalamic nucleus (STN)-DBS surgery without PEG hydrogel dural sealant capping. Group B consisted of 5 patients who underwent bilateral STN-DBS surgery with PEG hydrogel dural sealant capping. The immediate postoperative intracranial air volume was measured in all patients and compared between the 2 groups using the Welch test. Adverse effects were also examined in both groups. The intracranial air volume in Group A was 32.3 ± 12.3 ml (range 19.1-42.5 ml), whereas that in Group B was 1.3 ± 1.5 ml (range 0.0-3.5 ml), showing a significant difference (p < 0.005). No hemorrhage or venous air embolisms were observed in either group. The effect of brain shift was discriminated by STN recordings in Group B. These preliminary findings indicate that PEG hydrogel dural sealant capping may reduce adverse effects related to CSF leakage and brain shift during DBS surgery. PMID:23358161

  19. Rapid touch-stimulated movement in the androgynophore of Passiflora flowers (subgen. Decaloba; Sect. Xerogona): an adaptation to enhance cross-pollination?

    PubMed

    Scorza, Livia C T; Dornelas, Marcelo Carnier

    2014-01-01

    Plant touch-sensitive organs have been described since Darwin's observations and are related to a quick response to environment stimuli. Sensitive flower organs have been associated to an increase in the chances of cross pollination but there are few studies regarding this topic. Here we describe for the first time the kinetic of the androgynophore movement of 4 Passiflora species (P. sanguinolenta, P. citrina, P. capsularis, and P. rubra). For that, we collected flowers and recorded the movement after mechano-stimulating the androgynophore. From the recordings, we described the movement regarding its response and sensibility to mechanical stimulus and calculated the duration, speed, and the angle formed by the androgynophore before and after the movement. From our data we were able to propose a link to the pollination habit of these species. The movement of the androgynophore in these Passiflora is a noteworthy floral feature that might lead us to another astonishing example of a mechanism that evolved among angiosperms to assure sexual reproduction. PMID:24487079

  20. Gamma ray spectrometer for ITER

    SciTech Connect

    Gin, D.; Chugunov, I.; Shevelev, A.; Khilkevitch, E.; Doinikov, D.; Naidenov, V.; Pasternak, A.; Polunovsky, I.; Kiptily, V.

    2014-08-21

    Gamma diagnostics is considered to be primary for the confined α-particles and runaway electrons measurements on ITER. The gamma spectrometer will be embedded into a neutron dump of the ITER Neutral Particle Analyzer diagnostic complex. It will supplement NPA measurements on the fuel isotope ratio and confined alphas/fast ions. In this paper an update on ITER gamma spectrometer developments is given. A new geometry of the system is described and detailed analysis of expected signals for the spectrometer is presented.

  1. Recent progress and advances in iterative software (including parallel aspects)

    SciTech Connect

    Carey, G.; Young, D.M.; Kincaid, D.

    1994-12-31

    The purpose of the workshop is to provide a forum for discussion of the current state of iterative software packages. Of particular interest is software for large scale engineering and scientific applications, especially for distributed parallel systems. However, the authors will also review the state of software development for conventional architectures. This workshop will complement the other proposed workshops on iterative BLAS kernels and applications. The format for the workshop is as follows: To provide some structure, there will be brief presentations, each of less than five minutes duration and dealing with specific facets of the subject. These will be designed to focus the discussion and to stimulate an exchange with the participants. Issues to be covered include: The evolution of iterative packages, current state of the art, the parallel computing challenge, applications viewpoint, standards, and future directions and open problems.

  2. Channeled spectropolarimetry using iterative reconstruction

    NASA Astrophysics Data System (ADS)

    Lee, Dennis J.; LaCasse, Charles F.; Craven, Julia M.

    2016-05-01

    Channeled spectropolarimeters (CSP) measure the polarization state of light as a function of wavelength. Conventional Fourier reconstruction suffers from noise, assumes the channels are band-limited, and requires uniformly spaced samples. To address these problems, we propose an iterative reconstruction algorithm. We develop a mathematical model of CSP measurements and minimize a cost function based on this model. We simulate a measured spectrum using example Stokes parameters, from which we compare conventional Fourier reconstruction and iterative reconstruction. Importantly, our iterative approach can reconstruct signals that contain more bandwidth, an advancement over Fourier reconstruction. Our results also show that iterative reconstruction mitigates noise effects, processes non-uniformly spaced samples without interpolation, and more faithfully recovers the ground truth Stokes parameters. This work offers a significant improvement to Fourier reconstruction for channeled spectropolarimetry.

  3. ITER safety challenges and opportunities

    SciTech Connect

    Piet, S.J.

    1991-01-01

    Results of the Conceptual Design Activity (CDA) for the International Thermonuclear Experimental Reactor (ITER) suggest challenges and opportunities. ITER is capable of meeting anticipated regulatory dose limits,'' but proof is difficult because of large radioactive inventories needing stringent radioactivity confinement. We need much research and development (R D) and design analysis to establish that ITER meets regulatory requirements. We have a further opportunity to do more to prove more of fusion's potential safety and environmental advantages and maximize the amount of ITER technology on the path toward fusion power plants. To fulfill these tasks, we need to overcome three programmatic challenges and three technical challenges. The first programmatic challenge is to fund a comprehensive safety and environmental ITER R D plan. Second is to strengthen safety and environment work and personnel in the international team. Third is to establish an external consultant group to advise the ITER Joint Team on designing ITER to meet safety requirements for siting by any of the Parties. The first of the three key technical challenges is plasma engineering -- burn control, plasma shutdown, disruptions, tritium burn fraction, and steady state operation. The second is the divertor, including tritium inventory, activation hazards, chemical reactions, and coolant disturbances. The third technical challenge is optimization of design requirements considering safety risk, technical risk, and cost. Some design requirements are now too strict; some are too lax. Fuel cycle design requirements are presently too strict, mandating inappropriate T separation from H and D. Heat sink requirements are presently too lax; they should be strengthened to ensure that maximum loss of coolant accident temperatures drop.

  4. ITER Construction--Plant System Integration

    SciTech Connect

    Tada, E.; Matsuda, S.

    2009-02-19

    This brief paper introduces how the ITER will be built in the international collaboration. The ITER Organization plays a central role in constructing ITER and leading it into operation. Since most of the ITER components are to be provided in-kind from the member countries, integral project management should be scoped in advance of real work. Those include design, procurement, system assembly, testing, licensing and commissioning of ITER.

  5. ITER project and fusion technology

    NASA Astrophysics Data System (ADS)

    Takatsu, H.

    2011-09-01

    In the sessions of ITR, FTP and SEE of the 23rd IAEA Fusion Energy Conference, 159 papers were presented in total, highlighted by the remarkable progress of the ITER project: ITER baseline has been established and procurement activities have been started as planned with a target of realizing the first plasma in 2019; ITER physics basis is sound and operation scenarios and operational issues have been extensively studied in close collaboration with the worldwide physics community; the test blanket module programme has been incorporated into the ITER programme and extensive R&D works are ongoing in the member countries with a view to delivering their own modules in a timely manner according to the ITER master schedule. Good progress was also reported in the areas of a variety of complementary activities to DEMO, including Broader Approach activities and long-term technology. This paper summarizes the highlights of the papers presented in the ITR, FTP and SEE sessions with a minimum set of background information.

  6. Status of research toward the ITER disruption mitigation system

    SciTech Connect

    Hollmann, E. M.; Izzo, V. A.; Aleynikov, P. B.; Lehnen, M.; Snipes, J. A.; Fülöp, T.; Humphreys, D. A.; Lukash, V. E.; Papp, G.; Pautasso, G.; Saint-Laurent, F.

    2015-02-15

    An overview of the present status of research toward the final design of the ITER disruption mitigation system (DMS) is given. The ITER DMS is based on massive injection of impurities, in order to radiate the plasma stored energy and mitigate the potentially damaging effects of disruptions. The design of this system will be extremely challenging due to many physics and engineering constraints such as limitations on port access and the amount and species of injected impurities. Additionally, many physics questions relevant to the design of the ITER disruption mitigation system remain unsolved such as the mechanisms for mixing and assimilation of injected impurities during the rapid shutdown and the mechanisms for the subsequent formation and dissipation of runaway electron current.

  7. Is Carbon a Realistic Choice for ITER's Divertor?

    SciTech Connect

    C.H. Skinner; G. Federici

    2005-05-13

    Tritium retention by co-deposition with carbon on the divertor target plate is predicted to limit ITER's DT burning plasma operations (e.g. to about 100 pulses for the worst conditions) before the in-vessel tritium inventory limit, currently set at 350 g, is reached. At this point, ITER will only be able to continue its burning plasma program if technology is available that is capable of rapidly removing large quantities of tritium from the vessel with over 90% efficiency. The removal rate required is four orders of magnitude faster than that demonstrated in current tokamaks. Eighteen years after the observation of co-deposition on JET and TFTR, such technology is nowhere in sight. The inexorable conclusion is that either a major initiative in tritium removal should be funded or that research priorities for ITER should focus on metal alternatives.

  8. Construction Safety Forecast for ITER

    SciTech Connect

    cadwallader, lee charles

    2006-11-01

    The International Thermonuclear Experimental Reactor (ITER) project is poised to begin its construction activity. This paper gives an estimate of construction safety as if the experiment was being built in the United States. This estimate of construction injuries and potential fatalities serves as a useful forecast of what can be expected for construction of such a major facility in any country. These data should be considered by the ITER International Team as it plans for safety during the construction phase. Based on average U.S. construction rates, ITER may expect a lost workday case rate of < 4.0 and a fatality count of 0.5 to 0.9 persons per year.

  9. Error Field Correction in ITER

    SciTech Connect

    Park, Jong-kyu; Boozer, Allen H.; Menard, Jonathan E.; Schaffer, Michael J.

    2008-05-22

    A new method for correcting magnetic field errors in the ITER tokamak is developed using the Ideal Perturbed Equilibrium Code (IPEC). The dominant external magnetic field for driving islands is shown to be localized to the outboard midplane for three ITER equilibria that represent the projected range of operational scenarios. The coupling matrices between the poloidal harmonics of the external magnetic perturbations and the resonant fields on the rational surfaces that drive islands are combined for different equilibria and used to determine an ordered list of the dominant errors in the external magnetic field. It is found that efficient and robust error field correction is possible with a fixed setting of the correction currents relative to the currents in the main coils across the range of ITER operating scenarios that was considered.

  10. US--ITER activation analysis

    SciTech Connect

    Attaya, H.; Gohar, Y.; Smith, D.

    1990-09-01

    Activation analysis has been made for the US ITER design. The radioactivity and the decay heat have been calculated, during operation and after shutdown for the two ITER phases, the Physics Phase and the Technology Phase. The Physics Phase operates about 24 full power days (FPDs) at fusion power level of 1100 MW and the Technology Phase has 860 MW fusion power and operates for about 1360 FPDs. The point-wise gamma sources have been calculated everywhere in the reactor at several times after shutdown of the two phases and are then used to calculate the biological dose everywhere in the reactor. Activation calculations have been made also for ITER divertor. The results are presented for different continuous operation times and for only one pulse. The effect of the pulsed operation on the radioactivity is analyzed. 6 refs., 12 figs., 1 tab.

  11. The real mission of ITER

    SciTech Connect

    Wurden, G A

    2009-01-01

    For future machines, the plasma stored energy is going up by factors of 20-40x, and plasma currents by 2-3x, while the surface to volume ratio is at the same time decreasing. Therefore the disruption forces, even for constant B, (which scale like IxB), and associated possible localized heating on machine components, are more severe. Notably, Tore Supra has demonstrated removal of more than 1 GJ of input energy, over nearly a 400 second period. However, the instantaneous stored energy in the Tore Supra system (which is most directly related to the potential for disruption damage) is quite small compared to other large tokamaks. The goal of ITER is routinely described as studying DT burning plasmas with a Q {approx} 10. In reality, ITER has a much more important first order mission. In fact, if it fails at this mission, the consequences are that ITER will never get to the eventual stated purpose of studying a burning plasma. The real mission of ITER is to study (and demonstrate successfully) plasma control with {approx}10-17 MA toroidal currents and {approx}100-400 MJ plasma stored energy levels in long-pulse scenarios. Before DT operation is ever given a go-ahead in ITER, the reality is that ITER must demonstrate routine and reliable control of high energy hydrogen (and deuterium) plasmas. The difficulty is that ITER must simultaneously deal with several technical problems: (1) heat removal at the plasma/wall interface, (2) protection of the wall components from off-normal events, and (3) generation of dust/redeposition of first wall materials. All previous tokamaks have encountered hundred's of major disruptions in the course of their operation. The consequences of a few MA of runaway electrons (at 20-50 MeV) being generated in ITER, and then being lost to the walls are simply catastrophic. They will not be deposited globally, but will drift out (up, down, whatever, depending on control system), and impact internal structures, unless 'ameliorated'. Basically, this

  12. Iterated binomial sums and their associated iterated integrals

    NASA Astrophysics Data System (ADS)

    Ablinger, J.; Blümlein, J.; Raab, C. G.; Schneider, C.

    2014-11-01

    We consider finite iterated generalized harmonic sums weighted by the binomial binom{2k}{k} in numerators and denominators. A large class of these functions emerges in the calculation of massive Feynman diagrams with local operator insertions starting at 3-loop order in the coupling constant and extends the classes of the nested harmonic, generalized harmonic, and cyclotomic sums. The binomially weighted sums are associated by the Mellin transform to iterated integrals over square-root valued alphabets. The values of the sums for N → ∞ and the iterated integrals at x = 1 lead to new constants, extending the set of special numbers given by the multiple zeta values, the cyclotomic zeta values and special constants which emerge in the limit N → ∞ of generalized harmonic sums. We develop algorithms to obtain the Mellin representations of these sums in a systematic way. They are of importance for the derivation of the asymptotic expansion of these sums and their analytic continuation to N in {C}. The associated convolution relations are derived for real parameters and can therefore be used in a wider context, as, e.g., for multi-scale processes. We also derive algorithms to transform iterated integrals over root-valued alphabets into binomial sums. Using generating functions we study a few aspects of infinite (inverse) binomial sums.

  13. Delayed Over-Relaxation for iterative methods

    NASA Astrophysics Data System (ADS)

    Antuono, M.; Colicchio, G.

    2016-09-01

    We propose a variant of the relaxation step used in the most widespread iterative methods (e.g. Jacobi Over-Relaxation, Successive Over-Relaxation) which combines the iteration at the predicted step, namely (n + 1), with the iteration at step (n - 1). We provide a theoretical analysis of the proposed algorithm by applying such a delayed relaxation step to a generic (convergent) iterative scheme. We prove that, under proper assumptions, this significantly improves the convergence rate of the initial iterative method. As a relevant example, we apply the proposed algorithm to the solution of the Poisson equation, highlighting the advantages in comparison with classical iterative models.

  14. ODE System Solver W. Krylov Iteration & Rootfinding

    1991-09-09

    LSODKR is a new initial value ODE solver for stiff and nonstiff systems. It is a variant of the LSODPK and LSODE solvers, intended mainly for large stiff systems. The main differences between LSODKR and LSODE are the following: (a) for stiff systems, LSODKR uses a corrector iteration composed of Newton iteration and one of four preconditioned Krylov subspace iteration methods. The user must supply routines for the preconditioning operations, (b) Within the corrector iteration,more » LSODKR does automatic switching between functional (fixpoint) iteration and modified Newton iteration, (c) LSODKR includes the ability to find roots of given functions of the solution during the integration.« less

  15. Continued Fractions and Iterative Processes.

    ERIC Educational Resources Information Center

    Bevis, Jean H.; Boal, Jan L.

    1982-01-01

    Continued fractions and associated sequences are viewed to constitute a rich area of study for mathematics students, by supporting instruction on algebraic and computational skills, mathematical induction, convergence of sequences, and interpretation of function graphs. An iterative method of approximating square roots opens suggestions for…

  16. Energetic ions in ITER plasmas

    NASA Astrophysics Data System (ADS)

    Pinches, S. D.; Chapman, I. T.; Lauber, Ph. W.; Oliver, H. J. C.; Sharapov, S. E.; Shinohara, K.; Tani, K.

    2015-02-01

    This paper discusses the behaviour and consequences of the expected populations of energetic ions in ITER plasmas. It begins with a careful analytic and numerical consideration of the stability of Alfvén Eigenmodes in the ITER 15 MA baseline scenario. The stability threshold is determined by balancing the energetic ion drive against the dominant damping mechanisms and it is found that only in the outer half of the plasma ( r / a > 0.5 ) can the fast ions overcome the thermal ion Landau damping. This is in spite of the reduced numbers of alpha-particles and beam ions in this region but means that any Alfvén Eigenmode-induced redistribution is not expected to influence the fusion burn process. The influence of energetic ions upon the main global MHD phenomena expected in ITER's primary operating scenarios, including sawteeth, neoclassical tearing modes and Resistive Wall Modes, is also reviewed. Fast ion losses due to the non-axisymmetric fields arising from the finite number of toroidal field coils, the inclusion of ferromagnetic inserts, the presence of test blanket modules containing ferromagnetic material, and the fields created by the Edge Localised Mode (ELM) control coils in ITER are discussed. The greatest losses and associated heat loads onto the plasma facing components arise due to the use of the ELM control coils and come from neutral beam ions that are ionised in the plasma edge.

  17. Networking Theories by Iterative Unpacking

    ERIC Educational Resources Information Center

    Koichu, Boris

    2014-01-01

    An iterative unpacking strategy consists of sequencing empirically-based theoretical developments so that at each step of theorizing one theory serves as an overarching conceptual framework, in which another theory, either existing or emerging, is embedded in order to elaborate on the chosen element(s) of the overarching theory. The strategy is…

  18. Active beam spectroscopy for ITER

    NASA Astrophysics Data System (ADS)

    von Hellermann, M. G.; Barnsley, R.; Biel, W.; Delabie, E.; Hawkes, N.; Jaspers, R.; Johnson, D.; Klinkhamer, F.; Lischtschenko, O.; Marchuk, O.; Schunke, B.; Singh, M. J.; Snijders, B.; Summers, H. P.; Thomas, D.; Tugarinov, S.; Vasu, P.

    2010-11-01

    Since the first feasibility studies of active beam spectroscopy on ITER in 1995 the proposed diagnostic has developed into a well advanced and mature system. Substantial progress has been achieved on the physics side including comprehensive performance studies based on an advanced predictive code, which simulates active and passive features of the expected spectral ranges. The simulation has enabled detailed specifications for an optimized instrumentation and has helped to specify suitable diagnostic neutral beam parameters. Four ITER partners share presently the task of developing a suite of ITER active beam diagnostics, which make use of the two 0.5 MeV/amu 18 MW heating neutral beams and a dedicated 0.1 MeV/amu, 3.6 MW diagnostic neutral beam. The IN ITER team is responsible for the DNB development and also for beam physics related aspects of the diagnostic. The RF will be responsible for edge CXRS system covering the outer region of the plasma (1> r/ a>0.4) using an equatorial observation port, and the EU will develop the core CXRS system for the very core (0< r/ a<0.7) using a top observation port. Thus optimum radial resolution is ensured for each system with better than a/30 resolution. Finally, the US will develop a dedicated MSE system making use of the HNBs and two equatorial ports. With appropriate modification, these systems could also potentially provide information on alpha particle slowing-down features. . On the engineering side, comprehensive preparations were made involving the development of an observation periscope, a neutron labyrinth optical system and design studies for remote maintenance including the exchange of the first mirror assembly, a critical issue for the operation of the CXRS diagnostic in the harsh ITER environment. Additionally, an essential change of the orientation of the DNB injection angle and specification of suitable blanket aperture has been made to avoid trapped particle damage to the first wall.

  19. Object-oriented design of preconditioned iterative methods

    SciTech Connect

    Bruaset, A.M.

    1994-12-31

    In this talk the author discusses how object-oriented programming techniques can be used to develop a flexible software package for preconditioned iterative methods. The ideas described have been used to implement the linear algebra part of Diffpack, which is a collection of C++ class libraries that provides high-level tools for the solution of partial differential equations. In particular, this software package is aimed at rapid development of PDE-based numerical simulators, primarily using finite element methods.

  20. Boundary plasma modelling for ITER

    SciTech Connect

    Braams, B.J.

    1993-01-01

    Computer programs were developed to model the effect of nonaxisymmetric magnetic perturbations upon divertor heat load, and have explored what kind of externally applied perturbations are the most effective for heat load reduction without destroying core plasma confinement. We find that a carefully tuned set of coils located about 0.3 m outside the separatrix can be used to spread the heat load over about 0.1 m perpendicular to flux surfaces at the ITER divertor plate, even at a very low level of anomalous cross-field heat transport. As such a spreading would significantly extend the permissible regime of operation for ITER, we recommend that this study be pursued at the level of detail required for engineering design. In other work under this grant we are in the process of modifying the B2 code to handle correctly a non-orthogonal geometry.

  1. Bioinspired Iterative Synthesis of Polyketides

    NASA Astrophysics Data System (ADS)

    Hong, Ran; Zheng, Kuan; Xie, Changmin

    2015-05-01

    Diverse array of biopolymers and second metabolites (particularly polyketide natural products) has been manufactured in nature through an enzymatic iterative assembly of simple building blocks. Inspired by this strategy, molecules with inherent modularity can be efficiently synthesized by repeated succession of similar reaction sequences. This privileged strategy has been widely adopted in synthetic supramolecular chemistry. Its value also has been reorganized in natural product synthesis. A brief overview of this approach is given with a particular emphasis on the total synthesis of polyol-embedded polyketides, a class of vastly diverse structures and biologically significant natural products. This viewpoint also illustrates the limits of known individual modules in terms of diastereoselectivity and enantioselectivity. More efficient and practical iterative strategies are anticipated to emerge in the future development.

  2. Bioinspired iterative synthesis of polyketides

    PubMed Central

    Zheng, Kuan; Xie, Changmin; Hong, Ran

    2015-01-01

    Diverse array of biopolymers and second metabolites (particularly polyketide natural products) has been manufactured in nature through an enzymatic iterative assembly of simple building blocks. Inspired by this strategy, molecules with inherent modularity can be efficiently synthesized by repeated succession of similar reaction sequences. This privileged strategy has been widely adopted in synthetic supramolecular chemistry. Its value also has been reorganized in natural product synthesis. A brief overview of this approach is given with a particular emphasis on the total synthesis of polyol-embedded polyketides, a class of vastly diverse structures and biologically significant natural products. This viewpoint also illustrates the limits of known individual modules in terms of diastereoselectivity and enantioselectivity. More efficient and practical iterative strategies are anticipated to emerge in the future development. PMID:26052510

  3. ITER Plasma Control System Development

    NASA Astrophysics Data System (ADS)

    Snipes, Joseph; ITER PCS Design Team

    2015-11-01

    The development of the ITER Plasma Control System (PCS) continues with the preliminary design phase for 1st plasma and early plasma operation in H/He up to Ip = 15 MA in L-mode. The design is being developed through a contract between the ITER Organization and a consortium of plasma control experts from EU and US fusion laboratories, which is expected to be completed in time for a design review at the end of 2016. This design phase concentrates on breakdown including early ECH power and magnetic control of the poloidal field null, plasma current, shape, and position. Basic kinetic control of the heating (ECH, ICH, NBI) and fueling systems is also included. Disruption prediction, mitigation, and maintaining stable operation are also included because of the high magnetic and kinetic stored energy present already for early plasma operation. Support functions for error field topology and equilibrium reconstruction are also required. All of the control functions also must be integrated into an architecture that will be capable of the required complexity of all ITER scenarios. A database is also being developed to collect and manage PCS functional requirements from operational scenarios that were defined in the Conceptual Design with links to proposed event handling strategies and control algorithms for initial basic control functions. A brief status of the PCS development will be presented together with a proposed schedule for design phases up to DT operation.

  4. Progress on US ITER Diagnostics

    NASA Astrophysics Data System (ADS)

    Johnson, David; Feder, Russ

    2010-11-01

    There have been significant advances in the design concepts for the 8 ITER diagnostic systems being provided by the US. Concepts for integration of the diagnostics into the port plugs have also evolved. A prerequisite for the signoff of the procurement arrangements for these each diagnostic is a Conceptual Design Review organized by the ITER Organization. US experts under contract with the USIPO have been assisting the IO to prepare for these Reviews. In addition, a design team at PPPL has been working with these experts and designers from other ITER parties to package diagnostic front-ends into the 5 US plugs. Modular diagnostic shield modules are now being considered in order to simplify the interfaces between the diagnostics within each plug. Diagnostic first wall elements are envisioned to be integral with these shield modules. This simplifies the remote handling of the diagnostics and provides flexibility for future removal of one diagnostic minimally affecting others. Front-end configurations will be presented, along with lists of issues needing resolution prior to the start of preliminary design.

  5. Rapid Prototyping of Mobile Learning Games

    ERIC Educational Resources Information Center

    Federley, Maija; Sorsa, Timo; Paavilainen, Janne; Boissonnier, Kimo; Seisto, Anu

    2014-01-01

    This position paper presents the first results of an on-going project, in which we explore rapid prototyping method to efficiently produce digital learning solutions that are commercially viable. In this first phase, rapid game prototyping and an iterative approach was tested as a quick and efficient way to create learning games and to evaluate…

  6. Rater variables associated with ITER ratings.

    PubMed

    Paget, Michael; Wu, Caren; McIlwrick, Joann; Woloschuk, Wayne; Wright, Bruce; McLaughlin, Kevin

    2013-10-01

    Advocates of holistic assessment consider the ITER a more authentic way to assess performance. But this assessment format is subjective and, therefore, susceptible to rater bias. Here our objective was to study the association between rater variables and ITER ratings. In this observational study our participants were clerks at the University of Calgary and preceptors who completed online ITERs between February 2008 and July 2009. Our outcome variable was global rating on the ITER (rated 1-5), and we used a generalized estimating equation model to identify variables associated with this rating. Students were rated "above expected level" or "outstanding" on 66.4 % of 1050 online ITERs completed during the study period. Two rater variables attenuated ITER ratings: the log transformed time taken to complete the ITER [β = -0.06, 95 % confidence interval (-0.10, -0.02), p = 0.002], and the number of ITERs that a preceptor completed over the time period of the study [β = -0.008 (-0.02, -0.001), p = 0.02]. In this study we found evidence of leniency bias that resulted in two thirds of students being rated above expected level of performance. This leniency bias appeared to be attenuated by delay in ITER completion, and was also blunted in preceptors who rated more students. As all biases threaten the internal validity of the assessment process, further research is needed to confirm these and other sources of rater bias in ITER ratings, and to explore ways of limiting their impact.

  7. The physics role of ITER

    SciTech Connect

    Rutherford, P.H.

    1997-04-01

    Experimental research on the International Thermonuclear Experimental Reactor (ITER) will go far beyond what is possible on present-day tokamaks to address new and challenging issues in the physics of reactor-like plasmas. First and foremost, experiments in ITER will explore the physics issues of burning plasmas--plasmas that are dominantly self-heated by alpha-particles created by the fusion reactions themselves. Such issues will include (i) new plasma-physical effects introduced by the presence within the plasma of an intense population of energetic alpha particles; (ii) the physics of magnetic confinement for a burning plasma, which will involve a complex interplay of transport, stability and an internal self-generated heat source; and (iii) the physics of very-long-pulse/steady-state burning plasmas, in which much of the plasma current is also self-generated and which will require effective control of plasma purity and plasma-wall interactions. Achieving and sustaining burning plasma regimes in a tokamak necessarily requires plasmas that are larger than those in present experiments and have higher energy content and power flow, as well as much longer pulse length. Accordingly, the experimental program on ITER will embrace the study of issues of plasma physics and plasma-materials interactions that are specific to a reactor-scale fusion experiment. Such issues will include (i) confinement physics for a tokamak in which, for the first time, the core-plasma and the edge-plasma are simultaneously in a reactor-like regime; (ii) phenomena arising during plasma transients, including so-called disruptions, in regimes of high plasma current and thermal energy; and (iii) physics of a radiative divertor designed for handling high power flow for long pulses, including novel plasma and atomic-physics effects as well as materials science of surfaces subject to intense plasma interaction. Experiments on ITER will be conducted by researchers in control rooms situated at major

  8. Iterates of maps with symmetry

    NASA Technical Reports Server (NTRS)

    Chossat, Pascal; Golubitsky, Martin

    1988-01-01

    Fixed-point bifurcation, period doubling, and Hopf bifurcation (HB) for iterates of equivariant mappings are investigated analytically, with a focus on HB in the presence of symmetry. An algebraic formulation for the hypotheses of the theorem of Ruelle (1973) is derived, and the case of standing waves in a system of ordinary differential equations with O(2) symmetry is considered in detail. In this case, it is shown that HB can lead directly to motion on an invariant 3-torus, with an unexpected third frequency due to drift of standing waves along the torus.

  9. P-SPARSLIB: A parallel sparse iterative solution package

    SciTech Connect

    Saad, Y.

    1994-12-31

    Iterative methods are gaining popularity in engineering and sciences at a time where the computational environment is changing rapidly. P-SPARSLIB is a project to build a software library for sparse matrix computations on parallel computers. The emphasis is on iterative methods and the use of distributed sparse matrices, an extension of the domain decomposition approach to general sparse matrices. One of the goals of this project is to develop a software package geared towards specific applications. For example, the author will test the performance and usefulness of P-SPARSLIB modules on linear systems arising from CFD applications. Equally important is the goal of portability. In the long run, the author wishes to ensure that this package is portable on a variety of platforms, including SIMD environments and shared memory environments.

  10. ETR/ITER systems code

    SciTech Connect

    Barr, W.L.; Bathke, C.G.; Brooks, J.N.; Bulmer, R.H.; Busigin, A.; DuBois, P.F.; Fenstermacher, M.E.; Fink, J.; Finn, P.A.; Galambos, J.D.; Gohar, Y.; Gorker, G.E.; Haines, J.R.; Hassanein, A.M.; Hicks, D.R.; Ho, S.K.; Kalsi, S.S.; Kalyanam, K.M.; Kerns, J.A.; Lee, J.D.; Miller, J.R.; Miller, R.L.; Myall, J.O.; Peng, Y-K.M.; Perkins, L.J.; Spampinato, P.T.; Strickler, D.J.; Thomson, S.L.; Wagner, C.E.; Willms, R.S.; Reid, R.L.

    1988-04-01

    A tokamak systems code capable of modeling experimental test reactors has been developed and is described in this document. The code, named TETRA (for Tokamak Engineering Test Reactor Analysis), consists of a series of modules, each describing a tokamak system or component, controlled by an optimizer/driver. This code development was a national effort in that the modules were contributed by members of the fusion community and integrated into a code by the Fusion Engineering Design Center. The code has been checked out on the Cray computers at the National Magnetic Fusion Energy Computing Center and has satisfactorily simulated the Tokamak Ignition/Burn Experimental Reactor II (TIBER) design. A feature of this code is the ability to perform optimization studies through the use of a numerical software package, which iterates prescribed variables to satisfy a set of prescribed equations or constraints. This code will be used to perform sensitivity studies for the proposed International Thermonuclear Experimental Reactor (ITER). 22 figs., 29 tabs.

  11. ITER Port Interspace Pressure Calculations

    SciTech Connect

    Carbajo, Juan J; Van Hove, Walter A

    2016-01-01

    The ITER Vacuum Vessel (VV) is equipped with 54 access ports. Each of these ports has an opening in the bioshield that communicates with a dedicated port cell. During Tokamak operation, the bioshield opening must be closed with a concrete plug to shield the radiation coming from the plasma. This port plug separates the port cell into a Port Interspace (between VV closure lid and Port Plug) on the inner side and the Port Cell on the outer side. This paper presents calculations of pressures and temperatures in the ITER (Ref. 1) Port Interspace after a double-ended guillotine break (DEGB) of a pipe of the Tokamak Cooling Water System (TCWS) with high temperature water. It is assumed that this DEGB occurs during the worst possible conditions, which are during water baking operation, with water at a temperature of 523 K (250 C) and at a pressure of 4.4 MPa. These conditions are more severe than during normal Tokamak operation, with the water at 398 K (125 C) and 2 MPa. Two computer codes are employed in these calculations: RELAP5-3D Version 4.2.1 (Ref. 2) to calculate the blowdown releases from the pipe break, and MELCOR, Version 1.8.6 (Ref. 3) to calculate the pressures and temperatures in the Port Interspace. A sensitivity study has been performed to optimize some flow areas.

  12. Iterated Stretching of Viscoelastic Jets

    NASA Technical Reports Server (NTRS)

    Chang, Hsueh-Chia; Demekhin, Evgeny A.; Kalaidin, Evgeny

    1999-01-01

    We examine, with asymptotic analysis and numerical simulation, the iterated stretching dynamics of FENE and Oldroyd-B jets of initial radius r(sub 0), shear viscosity nu, Weissenberg number We, retardation number S, and capillary number Ca. The usual Rayleigh instability stretches the local uniaxial extensional flow region near a minimum in jet radius into a primary filament of radius [Ca(1 - S)/ We](sup 1/2)r(sub 0) between two beads. The strain-rate within the filament remains constant while its radius (elastic stress) decreases (increases) exponentially in time with a long elastic relaxation time 3We(r(sup 2, sub 0)/nu). Instabilities convected from the bead relieve the tension at the necks during this slow elastic drainage and trigger a filament recoil. Secondary filaments then form at the necks from the resulting stretching. This iterated stretching is predicted to occur successively to generate high-generation filaments of radius r(sub n), (r(sub n)/r(sub 0)) = square root of 2[r(sub n-1)/r(sub 0)](sup 3/2) until finite-extensibility effects set in.

  13. Experimental Evidence on Iterated Reasoning in Games

    PubMed Central

    Grehl, Sascha; Tutić, Andreas

    2015-01-01

    We present experimental evidence on two forms of iterated reasoning in games, i.e. backward induction and interactive knowledge. Besides reliable estimates of the cognitive skills of the subjects, our design allows us to disentangle two possible explanations for the observed limits in performed iterated reasoning: Restrictions in subjects’ cognitive abilities and their beliefs concerning the rationality of co-players. In comparison to previous literature, our estimates regarding subjects’ skills in iterated reasoning are quite pessimistic. Also, we find that beliefs concerning the rationality of co-players are completely irrelevant in explaining the observed limited amount of iterated reasoning in the dirty faces game. In addition, it is demonstrated that skills in backward induction are a solid predictor for skills in iterated knowledge, which points to some generalized ability of the subjects in iterated reasoning. PMID:26312486

  14. Preconditioned iterations to calculate extreme eigenvalues

    SciTech Connect

    Brand, C.W.; Petrova, S.

    1994-12-31

    Common iterative algorithms to calculate a few extreme eigenvalues of a large, sparse matrix are Lanczos methods or power iterations. They converge at a rate proportional to the separation of the extreme eigenvalues from the rest of the spectrum. Appropriate preconditioning improves the separation of the eigenvalues. Davidson`s method and its generalizations exploit this fact. The authors examine a preconditioned iteration that resembles a truncated version of Davidson`s method with a different preconditioning strategy.

  15. Research at ITER towards DEMO: Specific reactor diagnostic studies to be carried out on ITER

    SciTech Connect

    Krasilnikov, A. V.; Kaschuck, Y. A.; Vershkov, V. A.; Petrov, A. A.; Petrov, V. G.; Tugarinov, S. N.

    2014-08-21

    In ITER diagnostics will operate in the very hard radiation environment of fusion reactor. Extensive technology studies are carried out during development of the ITER diagnostics and procedures of their calibration and remote handling. Results of these studies and practical application of the developed diagnostics on ITER will provide the direct input to DEMO diagnostic development. The list of DEMO measurement requirements and diagnostics will be determined during ITER experiments on the bases of ITER plasma physics results and success of particular diagnostic application in reactor-like ITER plasma. Majority of ITER diagnostic already passed the conceptual design phase and represent the state of the art in fusion plasma diagnostic development. The number of related to DEMO results of ITER diagnostic studies such as design and prototype manufacture of: neutron and γ–ray diagnostics, neutral particle analyzers, optical spectroscopy including first mirror protection and cleaning technics, reflectometry, refractometry, tritium retention measurements etc. are discussed.

  16. Research at ITER towards DEMO: Specific reactor diagnostic studies to be carried out on ITER

    NASA Astrophysics Data System (ADS)

    Krasilnikov, A. V.; Kaschuck, Y. A.; Vershkov, V. A.; Petrov, A. A.; Petrov, V. G.; Tugarinov, S. N.

    2014-08-01

    In ITER diagnostics will operate in the very hard radiation environment of fusion reactor. Extensive technology studies are carried out during development of the ITER diagnostics and procedures of their calibration and remote handling. Results of these studies and practical application of the developed diagnostics on ITER will provide the direct input to DEMO diagnostic development. The list of DEMO measurement requirements and diagnostics will be determined during ITER experiments on the bases of ITER plasma physics results and success of particular diagnostic application in reactor-like ITER plasma. Majority of ITER diagnostic already passed the conceptual design phase and represent the state of the art in fusion plasma diagnostic development. The number of related to DEMO results of ITER diagnostic studies such as design and prototype manufacture of: neutron and γ-ray diagnostics, neutral particle analyzers, optical spectroscopy including first mirror protection and cleaning technics, reflectometry, refractometry, tritium retention measurements etc. are discussed.

  17. Plasma-surface interaction in the context of ITER.

    PubMed

    Kleyn, A W; Lopes Cardozo, N J; Samm, U

    2006-04-21

    The decreasing availability of energy and concern about climate change necessitate the development of novel sustainable energy sources. Fusion energy is such a source. Although it will take several decades to develop it into routinely operated power sources, the ultimate potential of fusion energy is very high and badly needed. A major step forward in the development of fusion energy is the decision to construct the experimental test reactor ITER. ITER will stimulate research in many areas of science. This article serves as an introduction to some of those areas. In particular, we discuss research opportunities in the context of plasma-surface interactions. The fusion plasma, with a typical temperature of 10 keV, has to be brought into contact with a physical wall in order to remove the helium produced and drain the excess energy in the fusion plasma. The fusion plasma is far too hot to be brought into direct contact with a physical wall. It would degrade the wall and the debris from the wall would extinguish the plasma. Therefore, schemes are developed to cool down the plasma locally before it impacts on a physical surface. The resulting plasma-surface interaction in ITER is facing several challenges including surface erosion, material redeposition and tritium retention. In this article we introduce how the plasma-surface interaction relevant for ITER can be studied in small scale experiments. The various requirements for such experiments are introduced and examples of present and future experiments will be given. The emphasis in this article will be on the experimental studies of plasma-surface interactions.

  18. Planning as an Iterative Process

    NASA Technical Reports Server (NTRS)

    Smith, David E.

    2012-01-01

    Activity planning for missions such as the Mars Exploration Rover mission presents many technical challenges, including oversubscription, consideration of time, concurrency, resources, preferences, and uncertainty. These challenges have all been addressed by the research community to varying degrees, but significant technical hurdles still remain. In addition, the integration of these capabilities into a single planning engine remains largely unaddressed. However, I argue that there is a deeper set of issues that needs to be considered namely the integration of planning into an iterative process that begins before the goals, objectives, and preferences are fully defined. This introduces a number of technical challenges for planning, including the ability to more naturally specify and utilize constraints on the planning process, the ability to generate multiple qualitatively different plans, and the ability to provide deep explanation of plans.

  19. ITER Safety Analyses with ISAS

    NASA Astrophysics Data System (ADS)

    Gulden, W.; Nisan, S.; Porfiri, M.-T.; Toumi, I.; de Gramont, T. Boubée

    1997-06-01

    Detailed analyses of accident sequences for the International Thermonuclear Experimental Reactor (ITER), from an initiating event to the environmental release of activity, have involved in the past the use of different types of computer codes in a sequential manner. Since these codes were developed at different time scales in different countries, there is no common computing structure to enable automatic data transfer from one code to the other, and no possibility exists to model or to quantify the effect of coupled physical phenomena. To solve this problem, the Integrated Safety Analysis System of codes (ISAS) is being developed, which allows users to integrate existing computer codes in a coherent manner. This approach is based on the utilization of a command language (GIBIANE) acting as a “glue” to integrate the various codes as modules of a common environment. The present version of ISAS allows comprehensive (coupled) calculations of a chain of codes such as ATHENA (thermal-hydraulic analysis of transients and accidents), INTRA (analysis of in-vessel chemical reactions, pressure built-up, and distribution of reaction products inside the vacuum vessel and adjacent rooms), and NAUA (transport of radiological species within buildings and to the environment). In the near future, the integration of S AFALY (simultaneous analysis of plasma dynamics and thermal behavior of in-vessel components) is also foreseen. The paper briefly describes the essential features of ISAS development and the associated software architecture. It gives first results of a typical ITER accident sequence, a loss of coolant accident (LOCA) in the divertor cooling loop inside the vacuum vessel, amply demonstrating ISAS capabilities.

  20. An accelerated subspace iteration for eigenvector derivatives

    NASA Technical Reports Server (NTRS)

    Ting, Tienko

    1991-01-01

    An accelerated subspace iteration method for calculating eigenvector derivatives has been developed. Factors affecting the effectiveness and the reliability of the subspace iteration are identified, and effective strategies concerning these factors are presented. The method has been implemented, and the results of a demonstration problem are presented.

  1. Iterative methods for weighted least-squares

    SciTech Connect

    Bobrovnikova, E.Y.; Vavasis, S.A.

    1996-12-31

    A weighted least-squares problem with a very ill-conditioned weight matrix arises in many applications. Because of round-off errors, the standard conjugate gradient method for solving this system does not give the correct answer even after n iterations. In this paper we propose an iterative algorithm based on a new type of reorthogonalization that converges to the solution.

  2. Rater Variables Associated with ITER Ratings

    ERIC Educational Resources Information Center

    Paget, Michael; Wu, Caren; McIlwrick, Joann; Woloschuk, Wayne; Wright, Bruce; McLaughlin, Kevin

    2013-01-01

    Advocates of holistic assessment consider the ITER a more authentic way to assess performance. But this assessment format is subjective and, therefore, susceptible to rater bias. Here our objective was to study the association between rater variables and ITER ratings. In this observational study our participants were clerks at the University of…

  3. New concurrent iterative methods with monotonic convergence

    SciTech Connect

    Yao, Qingchuan

    1996-12-31

    This paper proposes the new concurrent iterative methods without using any derivatives for finding all zeros of polynomials simultaneously. The new methods are of monotonic convergence for both simple and multiple real-zeros of polynomials and are quadratically convergent. The corresponding accelerated concurrent iterative methods are obtained too. The new methods are good candidates for the application in solving symmetric eigenproblems.

  4. TRANSP simulations of ITER plasmas

    SciTech Connect

    Budny, R.V.; McCune, D.C.; Redi, M.H.; Schivell, J.; Wieland, R.M.

    1995-12-01

    The TRANSP code is used to construct comprehensive, self-consistent models for ITER discharges. Plasma parameters are studied for two discharges from the ITER ``Interim Design`` database producing 1.5 GW fusion power with a plasma current of 21 MA and 20 toroidal field coils generating 5.7 T Steady state profiles for T{sub ion}, T{sub e}, n{sub e}, Z{sub eff}, and P{sub rad} from the database are specified. TRANSP models the full up/down asymmetric plasma boundary within the separatrix. Effects of high-energy neutral beam injection, sawteeth mixing, toroidal field ripple, and helium ash transport are included. Results are given for the fusion rate profiles, and parameters describing effects such as alpha particle slowing down, the heating of electrons and thermal ions, and the thermalization rates. The deposition of 1 MeV neutral beam ions is predicted to peak near the plasma center, and the average beam ion energy is predicted to be half the injected energy. Sawtooth mixing is predicted to broaden the fast alpha profile. The toroidal ripple losses rate of alpha energy is estimated to be 3% before sawtooth crashes and to increase by a factor of three to four immediately following sawtooth crashes. Assumptions for the thermal He transport and the He recycling coefficient at the boundary are discussed. If the ratio of helium and energy confinement times, {tau}*{sub He}/{tau}{sub E} is less than 15, the steady state fusion power is predicted to 1.5 GW or greater. The values of the transport coefficients required for this fusion power depend on the He recycling coefficient at the separatrix. If R{sub rec} is near 1, the required He diffusivity must be much larger than that measured in tokamaks. If R{sub rec} {le} 0.50, and if the inward pinch is small, values comparable to those measured are compatible with 1.5 GW.

  5. On the interplay between inner and outer iterations for a class of iterative methods

    SciTech Connect

    Giladi, E.

    1994-12-31

    Iterative algorithms for solving linear systems of equations often involve the solution of a subproblem at each step. This subproblem is usually another linear system of equations. For example, a preconditioned iteration involves the solution of a preconditioner at each step. In this paper, the author considers algorithms for which the subproblem is also solved iteratively. The subproblem is then said to be solved by {open_quotes}inner iterations{close_quotes} while the term {open_quotes}outer iteration{close_quotes} refers to a step of the basic algorithm. The cost of performing an outer iteration is dominated by the solution of the subproblem, and can be measured by the number of inner iterations. A good measure of the total amount of work needed to solve the original problem to some accuracy c is then, the total number of inner iterations. To lower the amount of work, one can consider solving the subproblems {open_quotes}inexactly{close_quotes} i.e. not to full accuracy. Although this diminishes the cost of solving each subproblem, it usually slows down the convergence of the outer iteration. It is therefore interesting to study the effect of solving each subproblem inexactly on the total amount of work. Specifically, the author considers strategies in which the accuracy to which the inner problem is solved, changes from one outer iteration to the other. The author seeks the `optimal strategy`, that is, the one that yields the lowest possible cost. Here, the author develops a methodology to find the optimal strategy, from the set of slowly varying strategies, for some iterative algorithms. This methodology is applied to the Chebychev iteration and it is shown that for Chebychev iteration, a strategy in which the inner-tolerance remains constant is optimal. The author also estimates this optimal constant. Then generalizations to other iterative procedures are discussed.

  6. Caloric stimulation

    MedlinePlus

    ... temperature, it should cause fast, side-to-side eye movements called nystagmus. The test is done in the ... Rapid, side-to-side eye movements should occur when cold or warm water is placed into the ear. The eye movements should be similar on both ...

  7. Modeling ITER ECH Waveguide Performance

    NASA Astrophysics Data System (ADS)

    Kaufman, M. C.; Lau, C. H.

    2014-10-01

    There are stringent requirements for mode purity and for on-target power as a percentage of source power for the ECH transmission lines on ITER. The design goal is less than 10% total power loss through the line and 95% HE11 mode at the diamond window. The dominant loss mechanism is mode conversion (MC) into higher order modes, and to maintain mode purity, these losses must be minimized. Miter bends and waveguide curvature are major sources of mode conversion. This work uses a code which calculates the mode conversion and attenuation of an arbitrary set of polarized waveguide modes in circular corrugated waveguide with non-zero axial curvature and miter bends. The transmission line is modeled as a structural beam with deformations due to misalignment of waveguide supports, tilts at the interfaces between waveguide sections, gravitational loading, and the extrusion and fabrication process. As these sources of curvature are statistical in nature, the resulting MC losses are found via Monte Carlo modeling. The results of this analysis will provide design guidance for waveguide support span lengths, requirements for minimum alignment offsets, and requirements for waveguide fabrication and quality control.

  8. Progress on ITER Diagnostic Integration

    NASA Astrophysics Data System (ADS)

    Johnson, David; Feder, Russ; Klabacha, Jonathan; Loesser, Doug; Messineo, Mike; Stratton, Brentley; Wood, Rick; Zhai, Yuhu; Andrew, Phillip; Barnsley, Robin; Bertschinger, Guenter; Debock, Maarten; Reichle, Roger; Udintsev, Victor; Vayakis, George; Watts, Christopher; Walsh, Michael

    2013-10-01

    On ITER, front-end components must operate reliably in a hostile environment. Many will be housed in massive port plugs, which also shield the machine from radiation. Multiple diagnostics reside in a single plug, presenting new challenges for developers. Front-end components must tolerate thermally-induced stresses, disruption-induced mechanical loads, stray ECH radiation, displacement damage, and degradation due to plasma-induced coatings. The impact of failures is amplified due to the difficulty in performing robotic maintenance on these large structures. Motivated by needs to minimize disruption loads on the plugs, standardize the handling of shield modules, and decouple the parallel efforts of the many parties, the packaging strategy for diagnostics has recently focused on the use of 3 vertical shield modules inserted from the plasma side into each equatorial plug structure. At the front of each is a detachable first wall element with customized apertures. Progress on US equatorial and upper plugs will be used as examples, including the layout of components in the interspace and port cell regions. Supported by PPPL under contract DE-AC02-09CH11466 and UT-Battelle, LLC under contract DE-AC05-00OR22725 with the U.S. DOE.

  9. Iterants, Fermions and Majorana Operators

    NASA Astrophysics Data System (ADS)

    Kauffman, Louis H.

    Beginning with an elementary, oscillatory discrete dynamical system associated with the square root of minus one, we study both the foundations of mathematics and physics. Position and momentum do not commute in our discrete physics. Their commutator is related to the diffusion constant for a Brownian process and to the Heisenberg commutator in quantum mechanics. We take John Wheeler's idea of It from Bit as an essential clue and we rework the structure of that bit to a logical particle that is its own anti-particle, a logical Marjorana particle. This is our key example of the amphibian nature of mathematics and the external world. We show how the dynamical system for the square root of minus one is essentially the dynamics of a distinction whose self-reference leads to both the fusion algebra and the operator algebra for the Majorana Fermion. In the course of this, we develop an iterant algebra that supports all of matrix algebra and we end the essay with a discussion of the Dirac equation based on these principles.

  10. Magnetic fusion and project ITER

    SciTech Connect

    Park, H.K.

    1992-01-01

    It has already been demonstrated that our economics and international relationship are impacted by an energy crisis. For the continuing prosperity of the human race, a new and viable energy source must be developed within the next century. It is evident that the cost will be high and will require a long term commitment to achieve this goal due to a high degree of technological and scientific knowledge. Energy from the controlled nuclear fusion is a safe, competitive, and environmentally attractive but has not yet been completely conquered. Magnetic fusion is one of the most difficult technological challenges. In modem magnetic fusion devices, temperatures that are significantly higher than the temperatures of the sun have been achieved routinely and the successful generation of tens of million watts as a result of scientific break-even is expected from the deuterium and tritium experiment within the next few years. For the practical future fusion reactor, we need to develop reactor relevant materials and technologies. The international project called International Thermonuclear Experimental Reactor (ITER)'' will fulfill this need and the success of this project will provide the most attractive long-term energy source for mankind.

  11. Magnetic fusion and project ITER

    SciTech Connect

    Park, H.K.

    1992-09-01

    It has already been demonstrated that our economics and international relationship are impacted by an energy crisis. For the continuing prosperity of the human race, a new and viable energy source must be developed within the next century. It is evident that the cost will be high and will require a long term commitment to achieve this goal due to a high degree of technological and scientific knowledge. Energy from the controlled nuclear fusion is a safe, competitive, and environmentally attractive but has not yet been completely conquered. Magnetic fusion is one of the most difficult technological challenges. In modem magnetic fusion devices, temperatures that are significantly higher than the temperatures of the sun have been achieved routinely and the successful generation of tens of million watts as a result of scientific break-even is expected from the deuterium and tritium experiment within the next few years. For the practical future fusion reactor, we need to develop reactor relevant materials and technologies. The international project called ``International Thermonuclear Experimental Reactor (ITER)`` will fulfill this need and the success of this project will provide the most attractive long-term energy source for mankind.

  12. RAVE: Rapid Visualization Environment

    NASA Technical Reports Server (NTRS)

    Klumpar, D. M.; Anderson, Kevin; Simoudis, Avangelos

    1994-01-01

    Visualization is used in the process of analyzing large, multidimensional data sets. However, the selection and creation of visualizations that are appropriate for the characteristics of a particular data set and the satisfaction of the analyst's goals is difficult. The process consists of three tasks that are performed iteratively: generate, test, and refine. The performance of these tasks requires the utilization of several types of domain knowledge that data analysts do not often have. Existing visualization systems and frameworks do not adequately support the performance of these tasks. In this paper we present the RApid Visualization Environment (RAVE), a knowledge-based system that interfaces with commercial visualization frameworks and assists a data analyst in quickly and easily generating, testing, and refining visualizations. RAVE was used for the visualization of in situ measurement data captured by spacecraft.

  13. The Employment of an Iterative Design Process to Develop a Pulmonary Graphical Display

    PubMed Central

    Wachter, S. Blake; Agutter, Jim; Syroid, Noah; Drews, Frank; Weinger, Matthew B.; Westenskow, Dwayne

    2003-01-01

    Objective: Data representations on today's medical monitors need to be improved to advance clinical awareness and prevent data vigilance errors. Simply building graphical displays does not ensure an improvement in clinical performance because displays have to be consistent with the user's clinical processes and mental models. In this report, the development of an original pulmonary graphical display for anesthesia is used as an example to show an iterative design process with built-in usability testing. Design: The process reported here is rapid, inexpensive, and requires a minimal number of subjects per development cycle. Three paper-based tests evaluated the anatomic, variable mapping, and graphical diagnostic meaning of the pulmonary display. Measurements: A confusion matrix compared the designer's intended answer with the subject's chosen answer. Considering deviations off the diagonal of the confusion matrix as design weaknesses, the pulmonary display was modified and retested. The iterative cycle continued until the anatomic and variable mapping cumulative test scores for a chosen design scored above 90% and the graphical diagnostic meaning test scored above 75%. Results: The iterative development test resulted in five design iterations. The final graphical pulmonary display improved the overall intuitiveness by 18%. The display was tested in three categories: anatomic features, variable mapping, and diagnostic accuracy. The anatomic intuitiveness increased by 25%, variable mapping intuitiveness increased by 34%, and diagnostic accuracy decreased slightly by 4%. Conclusion: With this rapid iterative development process, an intuitive graphical display can be developed inexpensively prior to formal testing in an experimental setting. PMID:12668693

  14. [MRI compatibility of deep brain stimulator].

    PubMed

    Zhang, Yujing

    2013-07-01

    Deep brain stimulation (DBS) therapy develops rapidly in clinical application. The structures of deep brain stimulator and magnetic resonance imaging (MRI) equipment are introduced, the interactions are analyzed, and the two compatible problems of radio frequency (RF) heating and imaging artifact are summarized in this paper.

  15. The Physics Basis of ITER Confinement

    SciTech Connect

    Wagner, F.

    2009-02-19

    ITER will be the first fusion reactor and the 50 year old dream of fusion scientists will become reality. The quality of magnetic confinement will decide about the success of ITER, directly in the form of the confinement time and indirectly because it decides about the plasma parameters and the fluxes, which cross the separatrix and have to be handled externally by technical means. This lecture portrays some of the basic principles which govern plasma confinement, uses dimensionless scaling to set the limits for the predictions for ITER, an approach which also shows the limitations of the predictions, and describes briefly the major characteristics and physics behind the H-mode--the preferred confinement regime of ITER.

  16. Designing Diagnostics to Survive in ITER

    NASA Astrophysics Data System (ADS)

    Watts, Christopher; ITER Team

    2014-10-01

    Adapting diagnostics to withstand the incredibly harsh environment of the ITER D-T plasma is a formidable engineering task. Hindrances include not only the nuclear environment, but also the high radiative heat fluxes, high particle fluxes and stray ECH radiation. Strategies to mitigate the impact of these run the gamut from shielding, through recessing, through appropriate materials selection, to refurbishment. Examples include the Langmuir probe system, where individual probes are protected by passive heat shields; retroreflectors recessed into the tokamak first wall in deep, baffled tunnels; plasma mirror cleaning systems; electronics components like piezo crystals and x-ray detectors vetted for the nuclear environment. These and other ITER diagnostic system designs will be highlighted to emphasize their strategies for dealing with the ITER environment. *The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

  17. Archimedes' Pi--An Introduction to Iteration.

    ERIC Educational Resources Information Center

    Lotspeich, Richard

    1988-01-01

    One method (attributed to Archimedes) of approximating pi offers a simple yet interesting introduction to one of the basic ideas of numerical analysis, an iteration sequence. The method is described and elaborated. (PK)

  18. Anderson Acceleration for Fixed-Point Iterations

    SciTech Connect

    Walker, Homer F.

    2015-08-31

    The purpose of this grant was to support research on acceleration methods for fixed-point iterations, with applications to computational frameworks and simulation problems that are of interest to DOE.

  19. On the safety of ITER accelerators.

    PubMed

    Li, Ge

    2013-01-01

    Three 1 MV/40A accelerators in heating neutral beams (HNB) are on track to be implemented in the International Thermonuclear Experimental Reactor (ITER). ITER may produce 500 MWt of power by 2026 and may serve as a green energy roadmap for the world. They will generate -1 MV 1 h long-pulse ion beams to be neutralised for plasma heating. Due to frequently occurring vacuum sparking in the accelerators, the snubbers are used to limit the fault arc current to improve ITER safety. However, recent analyses of its reference design have raised concerns. General nonlinear transformer theory is developed for the snubber to unify the former snubbers' different design models with a clear mechanism. Satisfactory agreement between theory and tests indicates that scaling up to a 1 MV voltage may be possible. These results confirm the nonlinear process behind transformer theory and map out a reliable snubber design for a safer ITER.

  20. Novel aspects of plasma control in ITER

    NASA Astrophysics Data System (ADS)

    Humphreys, D.; Ambrosino, G.; de Vries, P.; Felici, F.; Kim, S. H.; Jackson, G.; Kallenbach, A.; Kolemen, E.; Lister, J.; Moreau, D.; Pironti, A.; Raupp, G.; Sauter, O.; Schuster, E.; Snipes, J.; Treutterer, W.; Walker, M.; Welander, A.; Winter, A.; Zabeo, L.

    2015-02-01

    ITER plasma control design solutions and performance requirements are strongly driven by its nuclear mission, aggressive commissioning constraints, and limited number of operational discharges. In addition, high plasma energy content, heat fluxes, neutron fluxes, and very long pulse operation place novel demands on control performance in many areas ranging from plasma boundary and divertor regulation to plasma kinetics and stability control. Both commissioning and experimental operations schedules provide limited time for tuning of control algorithms relative to operating devices. Although many aspects of the control solutions required by ITER have been well-demonstrated in present devices and even designed satisfactorily for ITER application, many elements unique to ITER including various crucial integration issues are presently under development. We describe selected novel aspects of plasma control in ITER, identifying unique parts of the control problem and highlighting some key areas of research remaining. Novel control areas described include control physics understanding (e.g., current profile regulation, tearing mode (TM) suppression), control mathematics (e.g., algorithmic and simulation approaches to high confidence robust performance), and integration solutions (e.g., methods for management of highly subscribed control resources). We identify unique aspects of the ITER TM suppression scheme, which will pulse gyrotrons to drive current within a magnetic island, and turn the drive off following suppression in order to minimize use of auxiliary power and maximize fusion gain. The potential role of active current profile control and approaches to design in ITER are discussed. Issues and approaches to fault handling algorithms are described, along with novel aspects of actuator sharing in ITER.

  1. Iterative consolidation of unorganized point clouds.

    PubMed

    Liu, Shengjun; Chan, Kwan-Chung; Wang, Charlie C L

    2012-01-01

    Unorganized point clouds obtained from 3D shape acquisition devices usually present noise, outliers, and nonuniformities. The proposed framework consolidates unorganized points through an iterative procedure of interlaced downsampling and upsampling. Selection operations remove outliers while preserving geometric details. The framework improves the uniformity of points by moving the downsampled particles and refining point samples. Surface extrapolation fills missed regions. Moreover, an adaptive sampling strategy speeds up the iterations. Experimental results demonstrate the framework's effectiveness.

  2. Programmable Iterative Optical Image And Data Processing

    NASA Technical Reports Server (NTRS)

    Jackson, Deborah J.

    1995-01-01

    Proposed method of iterative optical image and data processing overcomes limitations imposed by loss of optical power after repeated passes through many optical elements - especially, beam splitters. Involves selective, timed combination of optical wavefront phase conjugation and amplification to regenerate images in real time to compensate for losses in optical iteration loops; timing such that amplification turned on to regenerate desired image, then turned off so as not to regenerate other, undesired images or spurious light propagating through loops from unwanted reflections.

  3. Iterative methods based upon residual averaging

    NASA Technical Reports Server (NTRS)

    Neuberger, J. W.

    1980-01-01

    Iterative methods for solving boundary value problems for systems of nonlinear partial differential equations are discussed. The methods involve subtracting an average of residuals from one approximation in order to arrive at a subsequent approximation. Two abstract methods in Hilbert space are given and application of these methods to quasilinear systems to give numerical schemes for such problems is demonstrated. Potential theoretic matters related to the iteration schemes are discussed.

  4. Threshold power and energy confinement for ITER

    SciTech Connect

    Takizuka, T.

    1996-12-31

    In order to predict the threshold power for L-H transition and the energy confinement performance in ITER, assembling of database and analyses of them have been progressed. The ITER Threshold Database includes data from 10 divertor tokamaks. Investigation of the database gives a scaling of the threshold power of the form P{sub thr} {proportional_to} B{sub t} n{sub e}{sup 0.75} R{sup 2} {times} (n{sub e} R{sup 2}){sup +-0.25}, which predicts P{sub thr} = 100 {times} 2{sup 0{+-}1} MW for ITER at n{sub e} = 5 {times} 10{sup 19} m{sup {minus}3}. The ITER L-mode Confinement Database has also been expanded by data from 14 tokamaks. A scaling of the thermal energy confinement time in L-mode and ohmic phases is obtained; {tau}{sub th} {approximately} I{sub p} R{sup 1.8} n{sub e}{sup 0.4{sub P{sup {minus}0.73}}}. At the ITER parameter, it becomes about 2.2 sec. For the ignition in ITER, more than 2.5 times of improvement will be required from the L-mode. The ITER H-mode Confinement Database is expanded from data of 6 tokamaks to data of 11 tokamaks. A {tau}{sub th} scaling for ELMy H-mode obtained by a standard regression analysis predicts the ITER confinement time of {tau}{sub th} = 6 {times} (1 {+-} 0.3) sec. The degradation of {tau}{sub th} with increasing n{sub e} R{sup 2} (or decreasing {rho}{sub *}) is not found for ELMy H-mode. An offset linear law scaling with a dimensionally correct form also predicts nearly the same {tau}{sub th} value.

  5. Novel aspects of plasma control in ITER

    SciTech Connect

    Humphreys, D.; Jackson, G.; Walker, M.; Welander, A.; Ambrosino, G.; Pironti, A.; Felici, F.; Kallenbach, A.; Raupp, G.; Treutterer, W.; Kolemen, E.; Lister, J.; Sauter, O.; Moreau, D.; Schuster, E.

    2015-02-15

    ITER plasma control design solutions and performance requirements are strongly driven by its nuclear mission, aggressive commissioning constraints, and limited number of operational discharges. In addition, high plasma energy content, heat fluxes, neutron fluxes, and very long pulse operation place novel demands on control performance in many areas ranging from plasma boundary and divertor regulation to plasma kinetics and stability control. Both commissioning and experimental operations schedules provide limited time for tuning of control algorithms relative to operating devices. Although many aspects of the control solutions required by ITER have been well-demonstrated in present devices and even designed satisfactorily for ITER application, many elements unique to ITER including various crucial integration issues are presently under development. We describe selected novel aspects of plasma control in ITER, identifying unique parts of the control problem and highlighting some key areas of research remaining. Novel control areas described include control physics understanding (e.g., current profile regulation, tearing mode (TM) suppression), control mathematics (e.g., algorithmic and simulation approaches to high confidence robust performance), and integration solutions (e.g., methods for management of highly subscribed control resources). We identify unique aspects of the ITER TM suppression scheme, which will pulse gyrotrons to drive current within a magnetic island, and turn the drive off following suppression in order to minimize use of auxiliary power and maximize fusion gain. The potential role of active current profile control and approaches to design in ITER are discussed. Issues and approaches to fault handling algorithms are described, along with novel aspects of actuator sharing in ITER.

  6. EDITORIAL: ECRH physics and technology in ITER

    NASA Astrophysics Data System (ADS)

    Luce, T. C.

    2008-05-01

    It is a great pleasure to introduce you to this special issue containing papers from the 4th IAEA Technical Meeting on ECRH Physics and Technology in ITER, which was held 6-8 June 2007 at the IAEA Headquarters in Vienna, Austria. The meeting was attended by more than 40 ECRH experts representing 13 countries and the IAEA. Presentations given at the meeting were placed into five separate categories EC wave physics: current understanding and extrapolation to ITER Application of EC waves to confinement and stability studies, including active control techniques for ITER Transmission systems/launchers: state of the art and ITER relevant techniques Gyrotron development towards ITER needs System integration and optimisation for ITER. It is notable that the participants took seriously the focal point of ITER, rather than simply contributing presentations on general EC physics and technology. The application of EC waves to ITER presents new challenges not faced in the current generation of experiments from both the physics and technology viewpoints. High electron temperatures and the nuclear environment have a significant impact on the application of EC waves. The needs of ITER have also strongly motivated source and launcher development. Finally, the demonstrated ability for precision control of instabilities or non-inductive current drive in addition to bulk heating to fusion burn has secured a key role for EC wave systems in ITER. All of the participants were encouraged to submit their contributions to this special issue, subject to the normal publication and technical merit standards of Nuclear Fusion. Almost half of the participants chose to do so; many of the others had been published in other publications and therefore could not be included in this special issue. The papers included here are a representative sample of the meeting. The International Advisory Committee also asked the three summary speakers from the meeting to supply brief written summaries (O. Sauter

  7. Analysis of self-excited induction generators using an iterative method

    SciTech Connect

    Chan, T.F.

    1995-09-01

    This paper describes the steady-state analysis of self-excited induction generators (SEIG) using an iterative method. By considering the conductances connected across the air gap nodes, an iteration procedure is developed of the determination of the self-excited per unit frequency, which enables the equivalent circuit to be completely solved. The proposed method involves only simple algebraic calculations, but the accuracy is good an convergence is rapid. The method is subsequently extended to include core loss effects and the analysis of SEIG with series capacitance compensation. Very good agreement between experimental and computed results has been obtained on a 2-kW laboratory machine.

  8. PREFACE: Progress in the ITER Physics Basis

    NASA Astrophysics Data System (ADS)

    Ikeda, K.

    2007-06-01

    I would firstly like to congratulate all who have contributed to the preparation of the `Progress in the ITER Physics Basis' (PIPB) on its publication and express my deep appreciation of the hard work and commitment of the many scientists involved. With the signing of the ITER Joint Implementing Agreement in November 2006, the ITER Members have now established the framework for construction of the project, and the ITER Organization has begun work at Cadarache. The review of recent progress in the physics basis for burning plasma experiments encompassed by the PIPB will be a valuable resource for the project and, in particular, for the current Design Review. The ITER design has been derived from a physics basis developed through experimental, modelling and theoretical work on the properties of tokamak plasmas and, in particular, on studies of burning plasma physics. The `ITER Physics Basis' (IPB), published in 1999, has been the reference for the projection methodologies for the design of ITER, but the IPB also highlighted several key issues which needed to be resolved to provide a robust basis for ITER operation. In the intervening period scientists of the ITER Participant Teams have addressed these issues intensively. The International Tokamak Physics Activity (ITPA) has provided an excellent forum for scientists involved in these studies, focusing their work on the high priority physics issues for ITER. Significant progress has been made in many of the issues identified in the IPB and this progress is discussed in depth in the PIPB. In this respect, the publication of the PIPB symbolizes the strong interest and enthusiasm of the plasma physics community for the success of the ITER project, which we all recognize as one of the great scientific challenges of the 21st century. I wish to emphasize my appreciation of the work of the ITPA Coordinating Committee members, who are listed below. Their support and encouragement for the preparation of the PIPB were

  9. Comparison of Iterative and Non-Iterative Strain-Gage Balance Load Calculation Methods

    NASA Technical Reports Server (NTRS)

    Ulbrich, N.

    2010-01-01

    The accuracy of iterative and non-iterative strain-gage balance load calculation methods was compared using data from the calibration of a force balance. Two iterative and one non-iterative method were investigated. In addition, transformations were applied to balance loads in order to process the calibration data in both direct read and force balance format. NASA's regression model optimization tool BALFIT was used to generate optimized regression models of the calibration data for each of the three load calculation methods. This approach made sure that the selected regression models met strict statistical quality requirements. The comparison of the standard deviation of the load residuals showed that the first iterative method may be applied to data in both the direct read and force balance format. The second iterative method, on the other hand, implicitly assumes that the primary gage sensitivities of all balance gages exist. Therefore, the second iterative method only works if the given balance data is processed in force balance format. The calibration data set was also processed using the non-iterative method. Standard deviations of the load residuals for the three load calculation methods were compared. Overall, the standard deviations show very good agreement. The load prediction accuracies of the three methods appear to be compatible as long as regression models used to analyze the calibration data meet strict statistical quality requirements. Recent improvements of the regression model optimization tool BALFIT are also discussed in the paper.

  10. Current status of the ITER MSE diagnostic

    NASA Astrophysics Data System (ADS)

    Yuh, Howard; Levinton, F.; La Fleur, H.; Foley, E.; Feder, R.; Zakharov, L.

    2013-10-01

    The U.S. is providing ITER with a Motional Stark Effect (MSE) diagnostic to provide a measurement to guide reconstructions of the plasma q-profile. The diagnostic design has gone through many iterations, driven primarily by the evolution of the ITER port plug design and the steering of the heating beams. The present two port, three view design viewing both heating beams and the DNB has recently passed a conceptual design review at the IO. The traditional line polarization (MSE-LP) technique employed on many devices around the world faces many challenges in ITER, including strong background light and mirror degradation. To mitigate these effects, a multi-wavelength polarimeter and high resolution spectrometer will be used to subtract polarized background, while retroreflecting polarizers will provide mirror calibration concurrent with MSE-LP measurements. However, without a proven plasma-facing mirror cleaning technique, inherent risks to MSE-LP remain. The high field and high beam energy on ITER offers optimal conditions for a spectroscopic measurement of the electric field using line splitting (MSE-LS), a technique which does not depend on mirror polarization properties. The current design is presented with a roadmap of the R&D needed to address remaining challenges. This work is supported by DOE contracts S009627-R and S012380-F.

  11. Iterative scatter correction based on artifact assessment

    NASA Astrophysics Data System (ADS)

    Wiegert, Jens; Hohmann, Steffen; Bertram, Matthias

    2008-03-01

    In this paper we propose a novel scatter correction methodology for X-ray based cone-beam CT that allows to combine the advantages of projection-based and volume-based correction approaches. The basic idea is to use a potentially non-optimal projection-based scatter correction method and to iteratively optimize its performance by repeatedly assessing remaining scatter-induced artifacts in intermediately reconstructed volumes. The novel approach exploits the fact that due to the flatness of the scatter-background, compensation itself is most easily performed in the projection-domain, while the scatter-induced artifacts can be better observed in the reconstructed volume. The presented method foresees to evaluate the scatter correction efficiency after each iteration by means of a quantitative measure characterizing the amount of residual cupping and to adjust the parameters of the projection-based scatter correction for the next iteration accordingly. The potential of this iterative scatter correction approach is demonstrated using voxelized Monte Carlo scatter simulations as ground truth. Using the proposed iterative scatter correction method, remarkable scatter correction performance was achieved both using simple parametric heuristic techniques as well as by optimizing previously published scatter estimation schemes. For the human head, scatter induced artifacts were reduced from initially 148 HU to less than 8.1 HU to 9.1 HU for different studied methods, corresponding to an artifact reduction exceeding 93%.

  12. Accelerating the weighted histogram analysis method by direct inversion in the iterative subspace

    PubMed Central

    Zhang, Cheng; Lai, Chun-Liang; Pettitt, B. Montgomery

    2016-01-01

    The weighted histogram analysis method (WHAM) for free energy calculations is a valuable tool to produce free energy differences with the minimal errors. Given multiple simulations, WHAM obtains from the distribution overlaps the optimal statistical estimator of the density of states, from which the free energy differences can be computed. The WHAM equations are often solved by an iterative procedure. In this work, we use a well-known linear algebra algorithm which allows for more rapid convergence to the solution. We find that the computational complexity of the iterative solution to WHAM and the closely-related multiple Bennett acceptance ratio (MBAR) method can be improved by using the method of direct inversion in the iterative subspace. We give examples from a lattice model, a simple liquid and an aqueous protein solution. PMID:27453632

  13. Fast generating Greenberger-Horne-Zeilinger state via iterative interaction pictures

    NASA Astrophysics Data System (ADS)

    Huang, Bi-Hua; Chen, Ye-Hong; Wu, Qi-Cheng; Song, Jie; Xia, Yan

    2016-10-01

    We delve a little deeper into the construction of shortcuts to adiabatic passage for three-level systems by iterative interaction picture (multiple Schrödinger dynamics). As an application example, we use the deduced iterative based shortcuts to rapidly generate the Greenberger-Horne-Zeilinger (GHZ) state in a three-atom system with the help of quantum Zeno dynamics. Numerical simulation shows the dynamics designed by the iterative picture method is physically feasible and the shortcut scheme performs much better than that using the conventional adiabatic passage techniques. Also, the influences of various decoherence processes are discussed by numerical simulation and the results prove that the scheme is fast and robust against decoherence and operational imperfection.

  14. Electrical stimulation in exercise training

    NASA Technical Reports Server (NTRS)

    Kroll, Walter

    1994-01-01

    muscle strength for over a century. Bigelow reported in 1894, for example, the use of electrical stimulation on a young man for the purpose of increasing muscle strength. Employing a rapidly alternating sinusoidal induced current and a dynamometer for strength testing, Bigelow reported that the total lifting capacity of a patient increased from 4328 pounds to 4639 pounds after only 25 minutes of stimulation. In 1965, Massey et al. reported on the use of an Isotron electrical stimulator that emitted a high frequency current. Interestingly enough, the frequencies used by Massey et al. and the frequencies used by Bigelow in 1894 were in the same range of frequencies reported by Kots as being the most effective in strength development. It would seem the Russian secret of high frequency electrical stimulation for strength development, then, is not a modern development at all.

  15. ITER Experts' meeting on density limits

    SciTech Connect

    Borrass, K.; Igitkhanov, Y.L.; Uckan, N.A.

    1989-12-01

    The necessity of achieving a prescribed wall load or fusion power essentially determines the plasma pressure in a device like ITER. The range of operation densities and temperatures compatible with this condition is constrained by the problems of power exhaust and the disruptive density limit. The maximum allowable heat loads on the divertor plates and the maximum allowable sheath edge temperature practically impose a lower limit on the operating densities, whereas the disruptive density limit imposes an upper limit. For most of the density limit scalings proposed in the past an overlap of the two constraints or at best a very narrow accessible density range is predicted for ITER. Improved understanding of the underlying mechanisms is therefore a crucial issue in order to provide a more reliable basis for extrapolation to ITER and to identify possible ways of alleviating the problem.

  16. Accelerating an iterative process by explicit annihilation

    NASA Technical Reports Server (NTRS)

    Jespersen, D. C.; Buning, P. G.

    1985-01-01

    A slowly convergent stationary iterative process can be accelerated by explicitly annihilating (i.e., eliminating) the dominant eigenvector component of the error. The dominant eigenvalue or complex pair of eigenvalues can be estimated from the solution during the iteration. The corresponding eigenvector or complex pair of eigenvectors can then be annihilated by applying an explicit Richardson process over the basic iterative method. This can be done entirely in real arithmetic by analytically combining the complex conjugate annihilation steps. The technique is applied to an implicit algorithm for the calculation of two dimensional steady transonic flow over a circular cylinder using the equations of compressible inviscid gas dynamics. This demonstrates the use of explicit annihilation on a nonlinear problem.

  17. Accelerating an iterative process by explicit annihilation

    NASA Technical Reports Server (NTRS)

    Jespersen, D. C.; Buning, P. G.

    1983-01-01

    A slowly convergent stationary iterative process can be accelerated by explicitly annihilating (i.e., eliminating) the dominant eigenvector component of the error. The dominant eigenvalue or complex pair of eigenvalues can be estimated from the solution during the iteration. The corresponding eigenvector or complex pair of eigenvectors can then be annihilated by applying an explicit Richardson process over the basic iterative method. This can be done entirely in real arithmetic by analytically combining the complex conjugate annihilation steps. The technique is applied to an implicit algorithm for the calculation of two dimensional steady transonic flow over a circular cylinder using the equations of compressible inviscid gas dynamics. This demonstrates the use of explicit annihilation on a nonlinear problem.

  18. Re-starting an Arnoldi iteration

    SciTech Connect

    Lehoucq, R.B.

    1996-12-31

    The Arnoldi iteration is an efficient procedure for approximating a subset of the eigensystem of a large sparse n x n matrix A. The iteration produces a partial orthogonal reduction of A into an upper Hessenberg matrix H{sub m} of order m. The eigenvalues of this small matrix H{sub m} are used to approximate a subset of the eigenvalues of the large matrix A. The eigenvalues of H{sub m} improve as estimates to those of A as m increases. Unfortunately, so does the cost and storage of the reduction. The idea of re-starting the Arnoldi iteration is motivated by the prohibitive cost associated with building a large factorization.

  19. Translating relational queries into iterative programs

    SciTech Connect

    Freytag, J.C.

    1987-01-01

    This book investigates the problem of translating relational queries into iterative programs using methods and techniques from the areas of functional programming and program transformation. The first part presents two algorithms which generate iterative programs from algebra-based query specifications. While the first algorithm is based on the transformation of recursive programs, the second uses functional expressions to generate the final iterative form. In the second part the same techniques generate efficient programs for the evaluation of aggregate functions in relational database systems. In several steps, programs which perform aggregation after sorting, are transformed into programs which perform aggregation while sorting. The third part then investigates the Lisp-dialect T as a possible implementation language for database systems.

  20. The ITER in-vessel system

    SciTech Connect

    Lousteau, D.C.

    1994-09-01

    The overall programmatic objective, as defined in the ITER Engineering Design Activities (EDA) Agreement, is to demonstrate the scientific and technological feasibility of fusion energy for peaceful purposes. The ITER EDA Phase, due to last until July 1998, will encompass the design of the device and its auxiliary systems and facilities, including the preparation of engineering drawings. The EDA also incorporates validating research and development (R&D) work, including the development and testing of key components. The purpose of this paper is to review the status of the design, as it has been developed so far, emphasizing the design and integration of those components contained within the vacuum vessel of the ITER device. The components included in the in-vessel systems are divertor and first wall; blanket and shield; plasma heating, fueling, and vacuum pumping equipment; and remote handling equipment.

  1. Global Asymptotic Behavior of Iterative Implicit Schemes

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sweby, P. K.

    1994-01-01

    The global asymptotic nonlinear behavior of some standard iterative procedures in solving nonlinear systems of algebraic equations arising from four implicit linear multistep methods (LMMs) in discretizing three models of 2 x 2 systems of first-order autonomous nonlinear ordinary differential equations (ODEs) is analyzed using the theory of dynamical systems. The iterative procedures include simple iteration and full and modified Newton iterations. The results are compared with standard Runge-Kutta explicit methods, a noniterative implicit procedure, and the Newton method of solving the steady part of the ODEs. Studies showed that aside from exhibiting spurious asymptotes, all of the four implicit LMMs can change the type and stability of the steady states of the differential equations (DEs). They also exhibit a drastic distortion but less shrinkage of the basin of attraction of the true solution than standard nonLMM explicit methods. The simple iteration procedure exhibits behavior which is similar to standard nonLMM explicit methods except that spurious steady-state numerical solutions cannot occur. The numerical basins of attraction of the noniterative implicit procedure mimic more closely the basins of attraction of the DEs and are more efficient than the three iterative implicit procedures for the four implicit LMMs. Contrary to popular belief, the initial data using the Newton method of solving the steady part of the DEs may not have to be close to the exact steady state for convergence. These results can be used as an explanation for possible causes and cures of slow convergence and nonconvergence of steady-state numerical solutions when using an implicit LMM time-dependent approach in computational fluid dynamics.

  2. An iterative framework for EEG-based image search: robust retrieval with weak classifiers.

    PubMed

    Ušćumlić, Marija; Chavarriaga, Ricardo; Millán, José Del R

    2013-01-01

    We revisit the framework for brain-coupled image search, where the Electroencephalography (EEG) channel under rapid serial visual presentation protocol is used to detect user preferences. Extending previous works on the synergy between content-based image labeling and EEG-based brain-computer interface (BCI), we propose a different perspective on iterative coupling. Previously, the iterations were used to improve the set of EEG-based image labels before propagating them to the unseen images for the final retrieval. In our approach we accumulate the evidence of the true labels for each image in the database through iterations. This is done by propagating the EEG-based labels of the presented images at each iteration to the rest of images in the database. Our results demonstrate a continuous improvement of the labeling performance across iterations despite the moderate EEG-based labeling (AUC <75%). The overall analysis is done in terms of the single-trial EEG decoding performance and the image database reorganization quality. Furthermore, we discuss the EEG-based labeling performance with respect to a search task given the same image database.

  3. An Iterative Framework for EEG-based Image Search: Robust Retrieval with Weak Classifiers

    PubMed Central

    Ušćumlić, Marija; Chavarriaga, Ricardo; Millán, José del R.

    2013-01-01

    We revisit the framework for brain-coupled image search, where the Electroencephalography (EEG) channel under rapid serial visual presentation protocol is used to detect user preferences. Extending previous works on the synergy between content-based image labeling and EEG-based brain-computer interface (BCI), we propose a different perspective on iterative coupling. Previously, the iterations were used to improve the set of EEG-based image labels before propagating them to the unseen images for the final retrieval. In our approach we accumulate the evidence of the true labels for each image in the database through iterations. This is done by propagating the EEG-based labels of the presented images at each iteration to the rest of images in the database. Our results demonstrate a continuous improvement of the labeling performance across iterations despite the moderate EEG-based labeling (AUC <75%). The overall analysis is done in terms of the single-trial EEG decoding performance and the image database reorganization quality. Furthermore, we discuss the EEG-based labeling performance with respect to a search task given the same image database. PMID:23977196

  4. Challenges and status of ITER conductor production

    NASA Astrophysics Data System (ADS)

    Devred, A.; Backbier, I.; Bessette, D.; Bevillard, G.; Gardner, M.; Jong, C.; Lillaz, F.; Mitchell, N.; Romano, G.; Vostner, A.

    2014-04-01

    Taking the relay of the large Hadron collider (LHC) at CERN, ITER has become the largest project in applied superconductivity. In addition to its technical complexity, ITER is also a management challenge as it relies on an unprecedented collaboration of seven partners, representing more than half of the world population, who provide 90% of the components as in-kind contributions. The ITER magnet system is one of the most sophisticated superconducting magnet systems ever designed, with an enormous stored energy of 51 GJ. It involves six of the ITER partners. The coils are wound from cable-in-conduit conductors (CICCs) made up of superconducting and copper strands assembled into a multistage cable, inserted into a conduit of butt-welded austenitic steel tubes. The conductors for the toroidal field (TF) and central solenoid (CS) coils require about 600 t of Nb3Sn strands while the poloidal field (PF) and correction coil (CC) and busbar conductors need around 275 t of Nb-Ti strands. The required amount of Nb3Sn strands far exceeds pre-existing industrial capacity and has called for a significant worldwide production scale up. The TF conductors are the first ITER components to be mass produced and are more than 50% complete. During its life time, the CS coil will have to sustain several tens of thousands of electromagnetic (EM) cycles to high current and field conditions, way beyond anything a large Nb3Sn coil has ever experienced. Following a comprehensive R&D program, a technical solution has been found for the CS conductor, which ensures stable performance versus EM and thermal cycling. Productions of PF, CC and busbar conductors are also underway. After an introduction to the ITER project and magnet system, we describe the ITER conductor procurements and the quality assurance/quality control programs that have been implemented to ensure production uniformity across numerous suppliers. Then, we provide examples of technical challenges that have been encountered and

  5. Tracking Solar Events through Iterative Refinement

    NASA Astrophysics Data System (ADS)

    Kempton, D. J.; Angryk, R. A.

    2015-11-01

    In this paper, we combine two approaches to multiple-target tracking: the first is a hierarchical approach to iteratively growing track fragments across gaps in detections; the second is a network flow based optimization method for data association. The network flow based optimization method is utilized for data association in an iteratively growing manner. This process is applied to solar data, retrieved from the Heliophysics Event Knowledge base (HEK) and utilizes precomputed image parameter values. These precomputed image parameter values are used to compare visual similarity of detected events, to determine the best matching track fragment associations, which leads to a globally optimal track fragment association hypothesis.

  6. Fatigue tests on the ITER PF jacket

    NASA Astrophysics Data System (ADS)

    Qin, Jinggang; Weiss, Klaus-Peter; Wu, Yu; Wu, Zhixiong; Li, Laifeng; Liu, Sheng

    2012-10-01

    This paper focuses on fatigue tests on the ITER Poloidal Field (PF) jacket made of 316L stainless steel material. During manufacture, the conductor will be compacted and spooled after cable insertion. Therefore, sample jackets were prepared under compaction, bending and straightening in order to simulate the status of PF conductor during manufacturing and winding. The fatigue properties of materials were measured at T < 7 K, including S-N and fatigue crack growth rate (FCGR). The testing results show that the present Chinese PF jacket has good fatigue properties, which conclude that the results are accordant with the requirements of ITER.

  7. Iterative method for generating correlated binary sequences

    NASA Astrophysics Data System (ADS)

    Usatenko, O. V.; Melnik, S. S.; Apostolov, S. S.; Makarov, N. M.; Krokhin, A. A.

    2014-11-01

    We propose an efficient iterative method for generating random correlated binary sequences with a prescribed correlation function. The method is based on consecutive linear modulations of an initially uncorrelated sequence into a correlated one. Each step of modulation increases the correlations until the desired level has been reached. The robustness and efficiency of the proposed algorithm are tested by generating sequences with inverse power-law correlations. The substantial increase in the strength of correlation in the iterative method with respect to single-step filtering generation is shown for all studied correlation functions. Our results can be used for design of disordered superlattices, waveguides, and surfaces with selective transport properties.

  8. A novel resistance iterative algorithm for CCOS

    NASA Astrophysics Data System (ADS)

    Zheng, Ligong; Zhang, Xuejun

    2006-08-01

    CCOS (Computer Control Optical Surfacing) technology is widely used for making aspheric mirrors. For most manufacturers, dwell time algorithm is usually employed to determine the route and dwell time of the small tools to converge the errors. In this article, a novel damp iterative algorithm is proposed. We chose revolutions of the small tool instead of dwell time to determine fabrication stratagem. By using resistance iterative algorithm, we can solve these revolutions. Several mirrors have been manufactured by this method, all of them have fulfilled the demand of the designers, a 1m aspheric mirror was finished within 3 months.

  9. Stability of a radiative mantle in ITER

    SciTech Connect

    Mahdavi, M.A.; Staebler, G.M.; Wood, R.D.; Whyte, D.G.; West, W.P.

    1996-12-01

    We report results of a study to evaluate the efficacy of various impurities for heat dispersal by a radiative mantle and radiative divertor(including SOL). We have derived a stability criterion for the mantle radiation which favors low Z impurities and low ratios of edge to core thermal conductivities. Since on the other hand the relative strength of boundary line radiation to core bremsstrahlung favors high Z impurities, we find that for the ITER physics phase argon is the best gaseous impurity for mantle radiation. For the engineering phase of ITER, more detailed analysis is needed to select between krypton and argon.

  10. Scheduling and rescheduling with iterative repair

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Davis, Eugene; Daun, Brian; Deale, Michael

    1992-01-01

    This paper describes the GERRY scheduling and rescheduling system being applied to coordinate Space Shuttle Ground Processing. The system uses constraint-based iterative repair, a technique that starts with a complete but possibly flawed schedule and iteratively improves it by using constraint knowledge within repair heuristics. In this paper we explore the tradeoff between the informedness and the computational cost of several repair heuristics. We show empirically that some knowledge can greatly improve the convergence speed of a repair-based system, but that too much knowledge, such as the knowledge embodied within the MIN-CONFLICTS lookahead heuristic, can overwhelm a system and result in degraded performance.

  11. Tritium Pumps for ITER Roughing System

    SciTech Connect

    Antipenkov, Alexander; Day, Christian; Mack, August; Wagner, Robert; Laesser, Rainer

    2005-07-15

    The ITER roughing system provides for both the initial pump-down of the vessel itself and the regular pump-out of the batch-regenerating cryopumps. This system must have a large pumping speed and cope with the radioactive gas tritium at the same time. The present paper shall highlight the results of the ITER roughing train optimization, discuss the modification of a Roots pump for tritium, and present the results of a ferrofluidic seal test and the first tests of a tailor-made tritium-proof Roots pump with inactive gases.

  12. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

    PubMed Central

    Zhou, Yongjun; Murphy, Annabel C.; Samborskyy, Markiyan; Prediger, Patricia; Dias, Luiz Carlos; Leadlay, Peter F.

    2015-01-01

    Summary Conglobatin is an unusual C2-symmetrical macrodiolide from the bacterium Streptomyces conglobatus with promising antitumor activity. Insights into the genes and enzymes that govern both the assembly-line production of the conglobatin polyketide and its dimerization are essential to allow rational alterations to be made to the conglobatin structure. We have used a rapid, direct in vitro cloning method to obtain the entire cluster on a 41-kbp fragment, encoding a modular polyketide synthase assembly line. The cloned cluster directs conglobatin biosynthesis in a heterologous host strain. Using a model substrate to mimic the conglobatin monomer, we also show that the conglobatin cyclase/thioesterase acts iteratively, ligating two monomers head-to-tail then re-binding the dimer product and cyclizing it. Incubation of two different monomers with the cyclase produces hybrid dimers and trimers, providing the first evidence that conglobatin analogs may in future become accessible through engineering of the polyketide synthase. PMID:26091168

  13. Model-based iterative learning control of Parkinsonian state in thalamic relay neuron

    NASA Astrophysics Data System (ADS)

    Liu, Chen; Wang, Jiang; Li, Huiyan; Xue, Zhiqin; Deng, Bin; Wei, Xile

    2014-09-01

    Although the beneficial effects of chronic deep brain stimulation on Parkinson's disease motor symptoms are now largely confirmed, the underlying mechanisms behind deep brain stimulation remain unclear and under debate. Hence, the selection of stimulation parameters is full of challenges. Additionally, due to the complexity of neural system, together with omnipresent noises, the accurate model of thalamic relay neuron is unknown. Thus, the iterative learning control of the thalamic relay neuron's Parkinsonian state based on various variables is presented. Combining the iterative learning control with typical proportional-integral control algorithm, a novel and efficient control strategy is proposed, which does not require any particular knowledge on the detailed physiological characteristics of cortico-basal ganglia-thalamocortical loop and can automatically adjust the stimulation parameters. Simulation results demonstrate the feasibility of the proposed control strategy to restore the fidelity of thalamic relay in the Parkinsonian condition. Furthermore, through changing the important parameter—the maximum ionic conductance densities of low-threshold calcium current, the dominant characteristic of the proposed method which is independent of the accurate model can be further verified.

  14. Iterative solution of the Helmholtz equation

    SciTech Connect

    Larsson, E.; Otto, K.

    1996-12-31

    We have shown that the numerical solution of the two-dimensional Helmholtz equation can be obtained in a very efficient way by using a preconditioned iterative method. We discretize the equation with second-order accurate finite difference operators and take special care to obtain non-reflecting boundary conditions. We solve the large, sparse system of equations that arises with the preconditioned restarted GMRES iteration. The preconditioner is of {open_quotes}fast Poisson type{close_quotes}, and is derived as a direct solver for a modified PDE problem.The arithmetic complexity for the preconditioner is O(n log{sub 2} n), where n is the number of grid points. As a test problem we use the propagation of sound waves in water in a duct with curved bottom. Numerical experiments show that the preconditioned iterative method is very efficient for this type of problem. The convergence rate does not decrease dramatically when the frequency increases. Compared to banded Gaussian elimination, which is a standard solution method for this type of problems, the iterative method shows significant gain in both storage requirement and arithmetic complexity. Furthermore, the relative gain increases when the frequency increases.

  15. Constructing Easily Iterated Functions with Interesting Properties

    ERIC Educational Resources Information Center

    Sprows, David J.

    2009-01-01

    A number of schools have recently introduced new courses dealing with various aspects of iteration theory or at least have found ways of including topics such as chaos and fractals in existing courses. In this note, we will consider a family of functions whose members are especially well suited to illustrate many of the concepts involved in these…

  16. First mirrors for diagnostic systems of ITER

    NASA Astrophysics Data System (ADS)

    Litnovsky, A.; Voitsenya, V. S.; Costley, A.; Donné, A. J. H.; SWG on First Mirrors of the ITPA Topical Group on Diagnostics

    2007-08-01

    The majority of optical diagnostics presently foreseen for ITER will implement in-vessel metallic mirrors as plasma-viewing components. Mirrors are used for the observation of the plasma radiation in a very wide wavelength range: from about 1 nm up to a few mm. In the hostile ITER environment, mirrors are subject to erosion, deposition, particle implantation and other adverse effects which will change their optical properties, affecting the entire performance of the respective diagnostic systems. The Specialists Working Group (SWG) on first mirrors was established under the wings of the International Tokamak Physics Activity (ITPA) Topical Group (TG) on Diagnostics to coordinate and guide the investigations on diagnostic mirrors towards the development of optimal, robust and durable solutions for ITER diagnostic systems. The results of tests of various ITER-candidate mirror materials, performed in Tore-Supra, TEXTOR, DIII-D, TCV, T-10, TRIAM-1M and LHD under various plasma conditions, as well as an overview of laboratory investigations of mirror performance and mirror cleaning techniques are presented in the paper. The current tasks in the R&D of diagnostic mirrors will be addressed.

  17. Asymptotic iteration approach to supersymmetric bistable potentials

    NASA Astrophysics Data System (ADS)

    Ciftci, H.; Özer, O.; P., Roy

    2012-01-01

    We examine quasi exactly solvable bistable potentials and their supersymmetric partners within the framework of the asymptotic iteration method (AIM). It is shown that the AIM produces excellent approximate spectra and that sometimes it is found to be more useful to use the partner potential for computation. We also discuss the direct application of the AIM to the Fokker—Planck equation.

  18. Matched filter based iterative adaptive approach

    NASA Astrophysics Data System (ADS)

    Nepal, Ramesh; Zhang, Yan Rockee; Li, Zhengzheng; Blake, William

    2016-05-01

    Matched Filter sidelobes from diversified LPI waveform design and sensor resolution are two important considerations in radars and active sensors in general. Matched Filter sidelobes can potentially mask weaker targets, and low sensor resolution not only causes a high margin of error but also limits sensing in target-rich environment/ sector. The improvement in those factors, in part, concern with the transmitted waveform and consequently pulse compression techniques. An adaptive pulse compression algorithm is hence desired that can mitigate the aforementioned limitations. A new Matched Filter based Iterative Adaptive Approach, MF-IAA, as an extension to traditional Iterative Adaptive Approach, IAA, has been developed. MF-IAA takes its input as the Matched Filter output. The motivation here is to facilitate implementation of Iterative Adaptive Approach without disrupting the processing chain of traditional Matched Filter. Similar to IAA, MF-IAA is a user parameter free, iterative, weighted least square based spectral identification algorithm. This work focuses on the implementation of MF-IAA. The feasibility of MF-IAA is studied using a realistic airborne radar simulator as well as actual measured airborne radar data. The performance of MF-IAA is measured with different test waveforms, and different Signal-to-Noise (SNR) levels. In addition, Range-Doppler super-resolution using MF-IAA is investigated. Sidelobe reduction as well as super-resolution enhancement is validated. The robustness of MF-IAA with respect to different LPI waveforms and SNR levels is also demonstrated.

  19. Iteration of Complex Functions and Newton's Method

    ERIC Educational Resources Information Center

    Dwyer, Jerry; Barnard, Roger; Cook, David; Corte, Jennifer

    2009-01-01

    This paper discusses some common iterations of complex functions. The presentation is such that similar processes can easily be implemented and understood by undergraduate students. The aim is to illustrate some of the beauty of complex dynamics in an informal setting, while providing a couple of results that are not otherwise readily available in…

  20. On the safety of ITER accelerators

    PubMed Central

    Li, Ge

    2013-01-01

    Three 1 MV/40A accelerators in heating neutral beams (HNB) are on track to be implemented in the International Thermonuclear Experimental Reactor (ITER). ITER may produce 500 MWt of power by 2026 and may serve as a green energy roadmap for the world. They will generate −1 MV 1 h long-pulse ion beams to be neutralised for plasma heating. Due to frequently occurring vacuum sparking in the accelerators, the snubbers are used to limit the fault arc current to improve ITER safety. However, recent analyses of its reference design have raised concerns. General nonlinear transformer theory is developed for the snubber to unify the former snubbers' different design models with a clear mechanism. Satisfactory agreement between theory and tests indicates that scaling up to a 1 MV voltage may be possible. These results confirm the nonlinear process behind transformer theory and map out a reliable snubber design for a safer ITER. PMID:24008267

  1. Solving Differential Equations Using Modified Picard Iteration

    ERIC Educational Resources Information Center

    Robin, W. A.

    2010-01-01

    Many classes of differential equations are shown to be open to solution through a method involving a combination of a direct integration approach with suitably modified Picard iterative procedures. The classes of differential equations considered include typical initial value, boundary value and eigenvalue problems arising in physics and…

  2. ITER faces further five-year delay

    NASA Astrophysics Data System (ADS)

    Clery, Daniel

    2016-06-01

    The €14bn ITER fusion reactor currently under construction in Cadarache, France, will require an additional cash injection of €4.6bn if it is to start up in 2025 - a target date that is already five years later than currently scheduled.

  3. Microtearing Instability In The ITER Pedestal

    SciTech Connect

    Wong, K. L.; Mikkelsen, D. R.; Rewoldt, G. M.; Budny, R.

    2010-12-01

    Unstable microtearing modes are discovered by the GS2 gyrokinetic siimulation code, in the pedestal region of a simulated ITER H-mode plasma with approximately 400 WM DT fusion power. Existing nonlinear theory indicates that these instabilities should produce stochastic magnetic fields and broaden the pedestal. The resulted electron thermal conductivity is estimated and the implications of these findings are discussed.

  4. Iteration and Anxiety in Mathematical Literature

    ERIC Educational Resources Information Center

    Capezzi, Rita; Kinsey, L. Christine

    2016-01-01

    We describe our experiences in team-teaching an honors seminar on mathematics and literature. We focus particularly on two of the texts we read: Georges Perec's "How to Ask Your Boss for a Raise" and Alain Robbe-Grillet's "Jealousy," both of which make use of iterative structures.

  5. Development of advanced inductive scenarios for ITER

    NASA Astrophysics Data System (ADS)

    Luce, T. C.; Challis, C. D.; Ide, S.; Joffrin, E.; Kamada, Y.; Politzer, P. A.; Schweinzer, J.; Sips, A. C. C.; Stober, J.; Giruzzi, G.; Kessel, C. E.; Murakami, M.; Na, Y.-S.; Park, J. M.; Polevoi, A. R.; Budny, R. V.; Citrin, J.; Garcia, J.; Hayashi, N.; Hobirk, J.; Hudson, B. F.; Imbeaux, F.; Isayama, A.; McDonald, D. C.; Nakano, T.; Oyama, N.; Parail, V. V.; Petrie, T. W.; Petty, C. C.; Suzuki, T.; Wade, M. R.; the ITPA Integrated Operation Scenario Topical Group Members; the ASDEX-Upgrade Team; the DIII-D Team; EFDA Contributors, JET; the JT-60U Team

    2014-01-01

    Since its inception in 2002, the International Tokamak Physics Activity topical group on Integrated Operational Scenarios (IOS) has coordinated experimental and modelling activity on the development of advanced inductive scenarios for applications in the ITER tokamak. The physics basis and the prospects for applications in ITER have been advanced significantly during that time, especially with respect to experimental results. The principal findings of this research activity are as follows. Inductive scenarios capable of higher normalized pressure (βN ⩾ 2.4) than the ITER baseline scenario (βN = 1.8) with normalized confinement at or above the standard H-mode scaling are well established under stationary conditions on the four largest diverted tokamaks (AUG, DIII-D, JET, JT-60U), demonstrated in a database of more than 500 plasmas from these tokamaks analysed here. The parameter range where high performance is achieved is broad in q95 and density normalized to the empirical density limit. MHD modes can play a key role in reaching stationary high performance, but also define the limits to achieved stability and confinement. Projection of performance in ITER from existing experiments uses empirical scalings and theory-based modelling. The status of the experimental validation of both approaches is summarized here. The database shows significant variation in the energy confinement normalized to standard H-mode confinement scalings, indicating the possible influence of additional physics variables absent from the scalings. Tests using the available information on rotation and the ratio of the electron and ion temperatures indicate neither of these variables in isolation can explain the variation in normalized confinement observed. Trends in the normalized confinement with the two dimensionless parameters that vary most from present-day experiments to ITER, gyroradius and collision frequency, are significant. Regression analysis on the multi-tokamak database has been

  6. Testing Short Samples of ITER Conductors and Projection of Their Performance in ITER Magnets

    SciTech Connect

    Martovetsky, N N

    2007-08-20

    Qualification of the ITER conductor is absolutely necessary. Testing large scale conductors is expensive and time consuming. To test straight 3-4m long samples in a bore of a split solenoid is a relatively economical way in comparison with fabrication of a coil to be tested in a bore of a background field solenoid. However, testing short sample may give ambiguous results due to different constraints in current redistribution in the cable or other end effects which are not present in the large magnet. This paper discusses processes taking place in the ITER conductor, conditions when conductor performance could be distorted and possible signal processing to deduce behavior of ITER conductors in ITER magnets from the test data.

  7. Reducing the latency of the Fractal Iterative Method to half an iteration

    NASA Astrophysics Data System (ADS)

    Béchet, Clémentine; Tallon, Michel

    2013-12-01

    The fractal iterative method for atmospheric tomography (FRiM-3D) has been introduced to solve the wavefront reconstruction at the dimensions of an ELT with a low-computational cost. Previous studies reported the requirement of only 3 iterations of the algorithm in order to provide the best adaptive optics (AO) performance. Nevertheless, any iterative method in adaptive optics suffer from the intrinsic latency induced by the fact that one iteration can start only once the previous one is completed. Iterations hardly match the low-latency requirement of the AO real-time computer. We present here a new approach to avoid iterations in the computation of the commands with FRiM-3D, thus allowing low-latency AO response even at the scale of the European ELT (E-ELT). The method highlights the importance of "warm-start" strategy in adaptive optics. To our knowledge, this particular way to use the "warm-start" has not been reported before. Futhermore, removing the requirement of iterating to compute the commands, the computational cost of the reconstruction with FRiM-3D can be simplified and at least reduced to half the computational cost of a classical iteration. Thanks to simulations of both single-conjugate and multi-conjugate AO for the E-ELT,with FRiM-3D on Octopus ESO simulator, we demonstrate the benefit of this approach. We finally enhance the robustness of this new implementation with respect to increasing measurement noise, wind speed and even modeling errors.

  8. Overview on Experiments On ITER-like Antenna On JET And ICRF Antenna Design For ITER

    SciTech Connect

    Nightingale, M. P. S.; Blackman, T.; Edwards, D.; Fanthome, J.; Graham, M.; Hamlyn-Harris, C.; Hancock, D.; Jacquet, P.; Mayoral, M.-L.; Monakhov, I.; Nicholls, K.; Stork, D.; Whitehurst, A.; Wilson, D.; Wooldridge, E.

    2009-11-26

    Following an overview of the ITER Ion Cyclotron Resonance Frequency (ICRF) system, the JET ITER-like antenna (ILA) will be described. The ILA was designed to test the following ITER issues: (a) reliable operation at power densities of order 8 MW/m{sup 2} at voltages up to 45 kV using a close-packed array of straps; (b) powering through ELMs using an internal (in-vacuum) conjugate-T junction; (c) protection from arcing in a conjugate-T configuration, using both existing and novel systems; and (d) resilience to disruption forces. ITER-relevant results have been achieved: operation at high coupled power density; control of the antenna matching elements in the presence of high inter-strap coupling, use of four conjugate-T systems (as would be used in ITER, should a conjugate-T approach be used); operation with RF voltages on the antenna structures up to 42 kV; achievement of ELM tolerance with a conjugate-T configuration by operating at 3{omega} real impedance at the conjugate-T point; and validation of arc detection systems on conjugate-T configurations in ELMy H-mode plasmas. The impact of these results on the predicted performance and design of the ITER antenna will be reviewed. In particular, the implications of the RF coupling measured on JET will be discussed.

  9. Iterative performance of various formulations of the SPN equations

    NASA Astrophysics Data System (ADS)

    Zhang, Yunhuang; Ragusa, Jean C.; Morel, Jim E.

    2013-11-01

    In this paper, the Standard, Composite, and Canonical forms of the Simplified PN (SPN) equations are reviewed and their corresponding iterative properties are compared. The Gauss-Seidel (FLIP), Explicit, and preconditioned Source Iteration iterative schemes have been analyzed for both isotropic and highly anisotropic (Fokker-Planck) scattering. The iterative performance of the various SPN forms is assessed using Fourier analysis, corroborated with numerical experiments.

  10. Transcranial magnetic stimulation and the human brain

    NASA Astrophysics Data System (ADS)

    Hallett, Mark

    2000-07-01

    Transcranial magnetic stimulation (TMS) is rapidly developing as a powerful, non-invasive tool for studying the human brain. A pulsed magnetic field creates current flow in the brain and can temporarily excite or inhibit specific areas. TMS of motor cortex can produce a muscle twitch or block movement; TMS of occipital cortex can produce visual phosphenes or scotomas. TMS can also alter the functioning of the brain beyond the time of stimulation, offering potential for therapy.

  11. Iterative smoothing and deconvolution of one- and two-dimensional elemental distribution data

    NASA Astrophysics Data System (ADS)

    Coote, G. E.

    1997-07-01

    The resolution of the data from many instruments can be improved, or the rate of data collection can be increased for the same final resolution, by applying to the data reliable algorithms for smoothing and deconvolution. Iterative methods which were formerly impractical can easily be applied on a small computer. An ingenious linear algorithm for deconvolution of one-dimensional data (van Cittert, 1931) gave much better results when Jansson (1963) introduced a relaxation function which ensured the results remained positive. Gold (1964) derived by a matrix approach a nonlinear algorithm which used a different method of comparison, but Xu et al. showed 30 years later that it is a special van Cittert algorithm with a variable relaxation function. Tests of Gold's method show that it is reliable and much faster than Jansson's algorithm, converging in 20 iterations or fewer. If a microprobe beam spot is to a good approximation square or rectangular a 2-D image can be smoothed or deconvolved in the X and Y directions independently, and the Gold algorithm has proved suitable for the deconvolution stage. Almost all smoothing methods will broaden narrow peaks, but an exception is the linear iterative method of Morrison (1962), which reduces any structure narrower than the resolution function. The negative feedback step used in the deconvolution algorithms is not possible in a smoothing algorithm. The method suffers from a halting problem, since it smoothes during early iterations but eventually reproduces the original data. This can be prevented by introducing a relaxation function which is unity for the first iteration but decreases rapidly with succeeding iterations.

  12. He's iteration formulation for solving nonlinear algebraic equations

    NASA Astrophysics Data System (ADS)

    Qian, W.-X.; Ye, Y.-H.; Chen, J.; Mo, L.-F.

    2008-02-01

    Newton iteration method is sensitive to initial guess and its slope. To overcome the shortcoming, He's iteration method is used to solve nonlinear algebraic equations where Newton iteration method becomes invalid. Some examples are given, showing that the method is effective.

  13. Development and benchmarking of TASSER(iter) for the iterative improvement of protein structure predictions.

    PubMed

    Lee, Seung Yup; Skolnick, Jeffrey

    2007-07-01

    To improve the accuracy of TASSER models especially in the limit where threading provided template alignments are of poor quality, we have developed the TASSER(iter) algorithm which uses the templates and contact restraints from TASSER generated models for iterative structure refinement. We apply TASSER(iter) to a large benchmark set of 2,773 nonhomologous single domain proteins that are < or = 200 in length and that cover the PDB at the level of 35% pairwise sequence identity. Overall, TASSER(iter) models have a smaller global average RMSD of 5.48 A compared to 5.81 A RMSD of the original TASSER models. Classifying the targets by the level of prediction difficulty (where Easy targets have a good template with a corresponding good threading alignment, Medium targets have a good template but a poor alignment, and Hard targets have an incorrectly identified template), TASSER(iter) (TASSER) models have an average RMSD of 4.15 A (4.35 A) for the Easy set and 9.05 A (9.52 A) for the Hard set. The largest reduction of average RMSD is for the Medium set where the TASSER(iter) models have an average global RMSD of 5.67 A compared to 6.72 A of the TASSER models. Seventy percent of the Medium set TASSER(iter) models have a smaller RMSD than the TASSER models, while 63% of the Easy and 60% of the Hard TASSER models are improved by TASSER(iter). For the foldable cases, where the targets have a RMSD to the native <6.5 A, TASSER(iter) shows obvious improvement over TASSER models: For the Medium set, it improves the success rate from 57.0 to 67.2%, followed by the Hard targets where the success rate improves from 32.0 to 34.8%, with the smallest improvement in the Easy targets from 82.6 to 84.0%. These results suggest that TASSER(iter) can provide more reliable predictions for targets of Medium difficulty, a range that had resisted improvement in the quality of protein structure predictions.

  14. Iterative most likely oriented point registration.

    PubMed

    Billings, Seth; Taylor, Russell

    2014-01-01

    A new algorithm for model based registration is presented that optimizes both position and surface normal information of the shapes being registered. This algorithm extends the popular Iterative Closest Point (ICP) algorithm by incorporating the surface orientation at each point into both the correspondence and registration phases of the algorithm. For the correspondence phase an efficient search strategy is derived which computes the most probable correspondences considering both position and orientation differences in the match. For the registration phase an efficient, closed-form solution provides the maximum likelihood rigid body alignment between the oriented point matches. Experiments by simulation using human femur data demonstrate that the proposed Iterative Most Likely Oriented Point (IMLOP) algorithm has a strong accuracy advantage over ICP and has increased ability to robustly identify a successful registration result.

  15. The Cryostat and Subsystems Development at ITER

    NASA Astrophysics Data System (ADS)

    Sekachev, Igor; Meekins, Michael; Sborchia, Carlo; Vitupier, Guillaume; Xie, Han; Zhou, Caipin

    ITER is a large experimental tokamak being built to research fusion power. The ITER cryostat is a multifunctional system which provides vacuum insulation for the superconducting magnets operating at 4.5 K and for the thermal shield operating at 80 K. It also serves as a structural support for the tokamak and provides access ways and corridors to the vacuum vessel for diagnostic lines of sight, additional heating beams and the deployment of remote handling equipment. The cryostat has feed-through penetrations for all the equipment connecting elements of systems outside the cryostat to the corresponding elements inside the cryostat. The cryostat is a vacuum containment vessel having a very large volume of ∼16000 m3 designed to be evacuated to a base pressure of 10-4 Pa. Design details of the cryostat and associated systems, including Torus Cryopump Housing (TCPH), are discussed. Status report of the cryostat developments is presented.

  16. Main challenges for ITER optical diagnostics

    SciTech Connect

    Vukolov, K. Yu.; Orlovskiy, I. I.; Alekseev, A. G.; Borisov, A. A.; Andreenko, E. N.; Kukushkin, A. B.; Lisitsa, V. S.; Neverov, V. S.

    2014-08-21

    The review is made of the problems of ITER optical diagnostics. Most of these problems will be related to the intensive neutron radiation from hot plasma. At a high level of radiation loads the most types of materials gradually change their properties. This effect is most critical for optical diagnostics because of degradation of optical glasses and mirrors. The degradation of mirrors, that collect the light from plasma, basically will be induced by impurity deposition and (or) sputtering by charge exchange atoms. Main attention is paid to the search of glasses for vacuum windows and achromatic lens which are stable under ITER irradiation conditions. The last results of irradiation tests in nuclear reactor of candidate silica glasses KU-1, KS-4V and TF 200 are presented. An additional problem is discussed that deals with the stray light produced by multiple reflections from the first wall of the intense light emitted in the divertor plasma.

  17. New iterative solvers for the NAG Libraries

    SciTech Connect

    Salvini, S.; Shaw, G.

    1996-12-31

    The purpose of this paper is to introduce the work which has been carried out at NAG Ltd to update the iterative solvers for sparse systems of linear equations, both symmetric and unsymmetric, in the NAG Fortran 77 Library. Our current plans to extend this work and include it in our other numerical libraries in our range are also briefly mentioned. We have added to the Library the new Chapter F11, entirely dedicated to sparse linear algebra. At Mark 17, the F11 Chapter includes sparse iterative solvers, preconditioners, utilities and black-box routines for sparse symmetric (both positive-definite and indefinite) linear systems. Mark 18 will add solvers, preconditioners, utilities and black-boxes for sparse unsymmetric systems: the development of these has already been completed.

  18. Main challenges for ITER optical diagnostics

    NASA Astrophysics Data System (ADS)

    Vukolov, K. Yu.; Orlovskiy, I. I.; Alekseev, A. G.; Borisov, A. A.; Andreenko, E. N.; Kukushkin, A. B.; Lisitsa, V. S.; Neverov, V. S.

    2014-08-01

    The review is made of the problems of ITER optical diagnostics. Most of these problems will be related to the intensive neutron radiation from hot plasma. At a high level of radiation loads the most types of materials gradually change their properties. This effect is most critical for optical diagnostics because of degradation of optical glasses and mirrors. The degradation of mirrors, that collect the light from plasma, basically will be induced by impurity deposition and (or) sputtering by charge exchange atoms. Main attention is paid to the search of glasses for vacuum windows and achromatic lens which are stable under ITER irradiation conditions. The last results of irradiation tests in nuclear reactor of candidate silica glasses KU-1, KS-4V and TF 200 are presented. An additional problem is discussed that deals with the stray light produced by multiple reflections from the first wall of the intense light emitted in the divertor plasma.

  19. High contrast laminography using iterative algorithms

    NASA Astrophysics Data System (ADS)

    Kroupa, M.; Jakubek, J.

    2011-01-01

    3D X-ray imaging of internal structure of large flat objects is often complicated by limited access to all viewing angles or extremely high absorption in certain directions, therefore the standard method of computed tomography (CT) fails. This problem can be solved by the method of laminography. During a laminographic measurement the imaging detector is placed close to the sample while the X-ray source irradiates both sample and detector at different angles. The application of the state-of-the-art pixel detector Medipix in laminography together with adapted tomographic iterative alghorithms for 3D reconstruction of sample structure has been investigated. Iterative algorithms such as EM (Expectation Maximization) and OSEM (Ordered Subset Expectation Maximization) improve the quality of the reconstruction and allow including more complex physical models. In this contribution results and proposed future approaches which could be used for resolution enhancement are presented.

  20. Statistical properties of an iterated arithmetic mapping

    SciTech Connect

    Feix, M.R.; Rouet, J.L.

    1994-07-01

    We study the (3x = 1)/2 problem from a probabilistic viewpoint and show a forgetting mechanism for the last k binary digits of the seed after k iterations. The problem is subsequently generalized to a trifurcation process, the (lx + m)/3 problem. Finally the sequence of a set of seeds is empirically shown to be equivalent to a random walk of the variable log{sub 2}x (or log{sub 3} x) though computer simulations.

  1. Iterative solutions to the Dirac equation

    SciTech Connect

    Ciftci, Hakan; Hall, Richard L.; Saad, Nasser

    2005-08-15

    We consider a single particle which is bound by a central potential and obeys the Dirac equation in d dimensions. We first apply the asymptotic iteration method to recover the known exact solutions for the pure Coulomb case. For a screened Coulomb potential and for a Coulomb plus linear potential with linear scalar confinement, the method is used to obtain accurate approximate solutions for both eigenvalues and wave functions.

  2. Iterative solution of high order compact systems

    SciTech Connect

    Spotz, W.F.; Carey, G.F.

    1996-12-31

    We have recently developed a class of finite difference methods which provide higher accuracy and greater stability than standard central or upwind difference methods, but still reside on a compact patch of grid cells. In the present study we investigate the performance of several gradient-type iterative methods for solving the associated sparse systems. Both serial and parallel performance studies have been made. Representative examples are taken from elliptic PDE`s for diffusion, convection-diffusion, and viscous flow applications.

  3. Iterates of a Berezin-type transform

    NASA Astrophysics Data System (ADS)

    Liu, Congwen

    2007-05-01

    Let be the open unit ball of and dV denote the Lebesgue measure on normalized so that the measure of equals 1. Suppose . The Berezin-type transform of f is defined by We prove that if then the iterates converge to the Poisson extension of the boundary values of f, as k-->[infinity]. This can be viewed as a higher dimensional generalization of a previous result obtained independently by Englis and Zhu.

  4. Iterative pass optimization of sequence data

    NASA Technical Reports Server (NTRS)

    Wheeler, Ward C.

    2003-01-01

    The problem of determining the minimum-cost hypothetical ancestral sequences for a given cladogram is known to be NP-complete. This "tree alignment" problem has motivated the considerable effort placed in multiple sequence alignment procedures. Wheeler in 1996 proposed a heuristic method, direct optimization, to calculate cladogram costs without the intervention of multiple sequence alignment. This method, though more efficient in time and more effective in cladogram length than many alignment-based procedures, greedily optimizes nodes based on descendent information only. In their proposal of an exact multiple alignment solution, Sankoff et al. in 1976 described a heuristic procedure--the iterative improvement method--to create alignments at internal nodes by solving a series of median problems. The combination of a three-sequence direct optimization with iterative improvement and a branch-length-based cladogram cost procedure, provides an algorithm that frequently results in superior (i.e., lower) cladogram costs. This iterative pass optimization is both computation and memory intensive, but economies can be made to reduce this burden. An example in arthropod systematics is discussed. c2003 The Willi Hennig Society. Published by Elsevier Science (USA). All rights reserved.

  5. Iterative solution of the semiconductor device equations

    SciTech Connect

    Bova, S.W.; Carey, G.F.

    1996-12-31

    Most semiconductor device models can be described by a nonlinear Poisson equation for the electrostatic potential coupled to a system of convection-reaction-diffusion equations for the transport of charge and energy. These equations are typically solved in a decoupled fashion and e.g. Newton`s method is used to obtain the resulting sequences of linear systems. The Poisson problem leads to a symmetric, positive definite system which we solve iteratively using conjugate gradient. The transport equations lead to nonsymmetric, indefinite systems, thereby complicating the selection of an appropriate iterative method. Moreover, their solutions exhibit steep layers and are subject to numerical oscillations and instabilities if standard Galerkin-type discretization strategies are used. In the present study, we use an upwind finite element technique for the transport equations. We also evaluate the performance of different iterative methods for the transport equations and investigate various preconditioners for a few generalized gradient methods. Numerical examples are given for a representative two-dimensional depletion MOSFET.

  6. Perturbation resilience and superiorization of iterative algorithms

    NASA Astrophysics Data System (ADS)

    Censor, Y.; Davidi, R.; Herman, G. T.

    2010-06-01

    Iterative algorithms aimed at solving some problems are discussed. For certain problems, such as finding a common point in the intersection of a finite number of convex sets, there often exist iterative algorithms that impose very little demand on computer resources. For other problems, such as finding that point in the intersection at which the value of a given function is optimal, algorithms tend to need more computer memory and longer execution time. A methodology is presented whose aim is to produce automatically for an iterative algorithm of the first kind a 'superiorized version' of it that retains its computational efficiency but nevertheless goes a long way toward solving an optimization problem. This is possible to do if the original algorithm is 'perturbation resilient', which is shown to be the case for various projection algorithms for solving the consistent convex feasibility problem. The superiorized versions of such algorithms use perturbations that steer the process in the direction of a superior feasible point, which is not necessarily optimal, with respect to the given function. After presenting these intuitive ideas in a precise mathematical form, they are illustrated in image reconstruction from projections for two different projection algorithms superiorized for the function whose value is the total variation of the image.

  7. Conformal mapping and convergence of Krylov iterations

    SciTech Connect

    Driscoll, T.A.; Trefethen, L.N.

    1994-12-31

    Connections between conformal mapping and matrix iterations have been known for many years. The idea underlying these connections is as follows. Suppose the spectrum of a matrix or operator A is contained in a Jordan region E in the complex plane with 0 not an element of E. Let {phi}(z) denote a conformal map of the exterior of E onto the exterior of the unit disk, with {phi}{infinity} = {infinity}. Then 1/{vert_bar}{phi}(0){vert_bar} is an upper bound for the optimal asymptotic convergence factor of any Krylov subspace iteration. This idea can be made precise in various ways, depending on the matrix iterations, on whether A is finite or infinite dimensional, and on what bounds are assumed on the non-normality of A. This paper explores these connections for a variety of matrix examples, making use of a new MATLAB Schwarz-Christoffel Mapping Toolbox developed by the first author. Unlike the earlier Fortran Schwarz-Christoffel package SCPACK, the new toolbox computes exterior as well as interior Schwarz-Christoffel maps, making it easy to experiment with spectra that are not necessarily symmetric about an axis.

  8. Modelling the ITER glow discharge plasma

    NASA Astrophysics Data System (ADS)

    Kogut, D.; Douai, D.; Hagelaar, G.; Pitts, R. A.

    2015-08-01

    The ITER glow discharge cleaning (GDC) system (Maruyama et al., 2012) is aimed to prepare in-vessel component surfaces prior to the machine start-up. In order to assess glow discharge uniformity and wall coverage, thus conditioning efficiency of the system, a new 2D multi-fluid model has been developed (Hagelaar, 2012). In this work the model is compared with published experimental data on GDC wall ion fluxes in JET and RFX (Douai et al., 2013; Canton et al., 2013). The simulations of H2-GDC in ITER for the case of 1 or 2 anodes indicate a good level of homogeneity of plasma parameters in the negative glow and of the wall ion flux in the common pressure domain for GDC: 0.1-0.5 Pa. Although the model geometry does not allow simulation of all seven ITER anodes operating simultaneously, the results can be extrapolated to the full system with an average ion current density of 0.21 A/m2, which is comparable to JET (0.10 A/m2).

  9. ITER Creation Safety File Expertise Results

    NASA Astrophysics Data System (ADS)

    Perrault, D.

    2013-06-01

    In March 2010, the ITER operator delivered the facility safety file to the French "Autorité de Sûreté Nucléaire" (ASN) as part of its request for the creation decree, legally necessary before building works can begin on the site. The French "Institut de Radioprotection et de Sûreté Nucléaire" (IRSN), in support to the ASN, recently completed its expertise of the safety measures proposed for ITER, on the basis of this file and of additional technical documents from the operator. This paper presents the IRSN's main conclusions. In particular, they focus on the radioactive materials involved, the safety and radiation protection demonstration (suitability of risk management measures…), foreseeable accidents, building and safety important component design and, finally, wastes and effluents to be produced. This assessment was just the first legally-required step in on-going safety monitoring of the ITER project, which will include other complete regulatory re-evaluations.

  10. The dynamics of iterated transportation simulations

    SciTech Connect

    Nagel, K.; Rickert, M.; Simon, P.M.

    1998-12-01

    Transportation-related decisions of people often depend on what everybody else is doing. For example, decisions about mode choice, route choice, activity scheduling, etc., can depend on congestion, caused by the aggregated behavior of others. From a conceptual viewpoint, this consistency problem causes a deadlock, since nobody can start planning because they do not know what everybody else is doing. It is the process of iterations that is examined in this paper as a method for solving the problem. In this paper, the authors concentrate on the aspect of the iterative process that is probably the most important one from a practical viewpoint, and that is the ``uniqueness`` or ``robustness`` of the results. Also, they define robustness more in terms of common sense than in terms of a mathematical formalism. For this, they do not only want a single iterative process to converge, but they want the result to be independent of any particular implementation. The authors run many computational experiments, sometimes with variations of the same code, sometimes with totally different code, in order to see if any of the results are robust against these changes.

  11. Evaluation of ITER MSE Viewing Optics

    SciTech Connect

    Allen, S; Lerner, S; Morris, K; Jayakumar, J; Holcomb, C; Makowski, M; Latkowski, J; Chipman, R

    2007-03-26

    The Motional Stark Effect (MSE) diagnostic on ITER determines the local plasma current density by measuring the polarization angle of light resulting from the interaction of a high energy neutral heating beam and the tokamak plasma. This light signal has to be transmitted from the edge and core of the plasma to a polarization analyzer located in the port plug. The optical system should either preserve the polarization information, or it should be possible to reliably calibrate any changes induced by the optics. This LLNL Work for Others project for the US ITER Project Office (USIPO) is focused on the design of the viewing optics for both the edge and core MSE systems. Several design constraints were considered, including: image quality, lack of polarization aberrations, ease of construction and cost of mirrors, neutron shielding, and geometric layout in the equatorial port plugs. The edge MSE optics are located in ITER equatorial port 3 and view Heating Beam 5, and the core system is located in equatorial port 1 viewing heating beam 4. The current work is an extension of previous preliminary design work completed by the ITER central team (ITER resources were not available to complete a detailed optimization of this system, and then the MSE was assigned to the US). The optimization of the optical systems at this level was done with the ZEMAX optical ray tracing code. The final LLNL designs decreased the ''blur'' in the optical system by nearly an order of magnitude, and the polarization blur was reduced by a factor of 3. The mirror sizes were reduced with an estimated cost savings of a factor of 3. The throughput of the system was greater than or equal to the previous ITER design. It was found that optical ray tracing was necessary to accurately measure the throughput. Metal mirrors, while they can introduce polarization aberrations, were used close to the plasma because of the anticipated high heat, particle, and neutron loads. These mirrors formed an intermediate

  12. Optical Stimulation of Neurons

    PubMed Central

    Thompson, Alexander C.; Stoddart, Paul R.; Jansen, E. Duco

    2014-01-01

    Our capacity to interface with the nervous system remains overwhelmingly reliant on electrical stimulation devices, such as electrode arrays and cuff electrodes that can stimulate both central and peripheral nervous systems. However, electrical stimulation has to deal with multiple challenges, including selectivity, spatial resolution, mechanical stability, implant-induced injury and the subsequent inflammatory response. Optical stimulation techniques may avoid some of these challenges by providing more selective stimulation, higher spatial resolution and reduced invasiveness of the device, while also avoiding the electrical artefacts that complicate recordings of electrically stimulated neuronal activity. This review explores the current status of optical stimulation techniques, including optogenetic methods, photoactive molecule approaches and infrared neural stimulation, together with emerging techniques such as hybrid optical-electrical stimulation, nanoparticle enhanced stimulation and optoelectric methods. Infrared neural stimulation is particularly emphasised, due to the potential for direct activation of neural tissue by infrared light, as opposed to techniques that rely on the introduction of exogenous light responsive materials. However, infrared neural stimulation remains imperfectly understood, and techniques for accurately delivering light are still under development. While the various techniques reviewed here confirm the overall feasibility of optical stimulation, a number of challenges remain to be overcome before they can deliver their full potential. PMID:26322269

  13. Multicolor stimulated Raman scattering microscopy

    NASA Astrophysics Data System (ADS)

    Lu, Fa-Ke; Ji, Minbiao; Fu, Dan; Ni, Xiaohui; Freudiger, Christian W.; Holtom, Gary; Xie, X. Sunney

    2012-08-01

    Stimulated Raman scattering (SRS) microscopy has opened up a wide range of biochemical imaging applications by probing a particular Raman-active molecule vibrational mode in the specimen. However, the original implementation with picosecond pulse excitation can only realize rapid chemical mapping with a single Raman band. Here we present a novel SRS microscopic technique using a grating-based pulse shaper for excitation and a grating-based spectrograph for detection to achieve simultaneous multicolor SRS imaging with high sensitivity and high acquisition speeds. In particular, we use a linear combination of the measured CH2 and CH3 stretching signals to map the distributions of protein and lipid contents simultaneously.

  14. Research on JET in view of ITER

    NASA Astrophysics Data System (ADS)

    Pamela, Jerome; Ongena, Jef; Watkins, Michael

    2004-11-01

    Research on JET is focused on further development of the two ITER reference plasma scenarios. The ELMy H-Mode, has been extended to lower rho* at high and q_95=3, with simultaneously H_98=0.9, and f_GW=0.9 at I_p=3.5 MA. The dependence of confinement on beta and rho* has been found to be more favorable than given by the IPB98(y,2) scaling. Highlights in the development of Advanced Regimes with Internal Transport Barriers (ITB) and strong reversed shear (q_0=2-3, q_min=1.5-2.5) are : (i) operation at a core density close to the Greenwald limit and (ii) full current drive in 3T/1.8MA ITB plasmas extended to 20 seconds with a JET record injected energy of E≈ 330MJ; (iii) 7 keV Te≈ Ti ITB plasmas at low toroidal rotation, and (iv) wide radius ITB's (r/a=0.6). Furthermore, emphasis in JET is placed on (i) mitigating the impact of ELMs, (ii) understanding the phenomena leading to tritium retention and (iii) preparing burning plasma physics. Recent developments on JET in view of ITER are : (i) real-time control in both ELMy H-Mode and ITB plasmas and (ii) an upgrade of JET with: (a) increased NBI power (b) a new ELM-resilient ITER-like ICRH antenna (7MW) to be tested in 2006 (c) 16 new and upgraded diagnostics.

  15. Experimental studies of ITER demonstration discharges

    NASA Astrophysics Data System (ADS)

    Sips, A. C. C.; Casper, T. A.; Doyle, E. J.; Giruzzi, G.; Gribov, Y.; Hobirk, J.; Hogeweij, G. M. D.; Horton, L. D.; Hubbard, A. E.; Hutchinson, I.; Ide, S.; Isayama, A.; Imbeaux, F.; Jackson, G. L.; Kamada, Y.; Kessel, C.; Kochl, F.; Lomas, P.; Litaudon, X.; Luce, T. C.; Marmar, E.; Mattei, M.; Nunes, I.; Oyama, N.; Parail, V.; Portone, A.; Saibene, G.; Sartori, R.; Stober, J. K.; Suzuki, T.; Wolfe, S. M.; C-Mod Team; ASDEX Upgrade Team; DIII-D Team; JET EFDA Contributors

    2009-08-01

    Key parts of the ITER scenarios are determined by the capability of the proposed poloidal field (PF) coil set. They include the plasma breakdown at low loop voltage, the current rise phase, the performance during the flat top (FT) phase and a ramp down of the plasma. The ITER discharge evolution has been verified in dedicated experiments. New data are obtained from C-Mod, ASDEX Upgrade, DIII-D, JT-60U and JET. Results show that breakdown for Eaxis < 0.23-0.33 V m-1 is possible unassisted (ohmic) for large devices like JET and attainable in devices with a capability of using ECRH assist. For the current ramp up, good control of the plasma inductance is obtained using a full bore plasma shape with early X-point formation. This allows optimization of the flux usage from the PF set. Additional heating keeps li(3) < 0.85 during the ramp up to q95 = 3. A rise phase with an H-mode transition is capable of achieving li(3) < 0.7 at the start of the FT. Operation of the H-mode reference scenario at q95 ~ 3 and the hybrid scenario at q95 = 4-4.5 during the FT phase is documented, providing data for the li (3) evolution after the H-mode transition and the li (3) evolution after a back-transition to L-mode. During the ITER ramp down it is important to remain diverted and to reduce the elongation. The inductance could be kept <=1.2 during the first half of the current decay, using a slow Ip ramp down, but still consuming flux from the transformer. Alternatively, the discharges can be kept in H-mode during most of the ramp down, requiring significant amounts of additional heating.

  16. Corneal topography matching by iterative registration.

    PubMed

    Wang, Junjie; Elsheikh, Ahmed; Davey, Pinakin G; Wang, Weizhuo; Bao, Fangjun; Mottershead, John E

    2014-11-01

    Videokeratography is used for the measurement of corneal topography in overlapping portions (or maps) which must later be joined together to form the overall topography of the cornea. The separate portions are measured from different viewpoints and therefore must be brought together by registration of measurement points in the regions of overlap. The central map is generally the most accurate, but all maps are measured with uncertainty that increases towards the periphery. It becomes the reference (or static) map, and the peripheral (or dynamic) maps must then be transformed by rotation and translation so that the overlapping portions are matched. The process known as registration, of determining the necessary transformation, is a well-understood procedure in image analysis and has been applied in several areas of science and engineering. In this article, direct search optimisation using the Nelder-Mead algorithm and several variants of the iterative closest/corresponding point routine are explained and applied to simulated and real clinical data. The measurement points on the static and dynamic maps are generally different so that it becomes necessary to interpolate, which is done using a truncated series of Zernike polynomials. The point-to-plane iterative closest/corresponding point variant has the advantage of releasing certain optimisation constraints that lead to persistent registration and alignment errors when other approaches are used. The point-to-plane iterative closest/corresponding point routine is found to be robust to measurement noise, insensitive to starting values of the transformation parameters and produces high-quality results when using real clinical data.

  17. Iterative repair for scheduling and rescheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Davis, Eugene; Deale, Michael

    1991-01-01

    An iterative repair search method is described called constraint based simulated annealing. Simulated annealing is a hill climbing search technique capable of escaping local minima. The utility of the constraint based framework is shown by comparing search performance with and without the constraint framework on a suite of randomly generated problems. Results are also shown of applying the technique to the NASA Space Shuttle ground processing problem. These experiments show that the search methods scales to complex, real world problems and reflects interesting anytime behavior.

  18. Iterative phase retrieval strategy of transient events.

    PubMed

    Ng, Tuck Wah; Chua, Adrian Sau Ling

    2012-01-20

    Important nuances of a process or processes in action can be obtained from the phase retrieval of diffraction patterns for analysis of transient events. A significant limitation associated with the iterative approach is that predictive input functions are needed and can result in situations of nonconvergence. In dealing with a transient event recorded as a series of Fourier magnitude patterns, such a hit-and-miss characteristic, on the surface, appears computationally daunting. We report and demonstrate a strategy here that effectively minimizes this by using a prior retrieved frame as the predictive function for the current retrieval process. PMID:22270666

  19. Design of the ITER ICRF Antenna

    NASA Astrophysics Data System (ADS)

    Hancock, D.; Nightingale, M.; Bamber, R.; Dalton, N.; Durodie, F.; Firdaouss, M.; Lister, J.; Porton, M.; Shannon, M.; Wilson, D.; Winkler, K.; Wooldridge, E.

    2011-12-01

    The CYCLE consortium has been designing the ITER ICRF antenna since March 2010, supported by an F4E grant. Following a brief introduction to the consortium, this paper: describes the present status and layout of the design; highlights the key mechanical engineering features; shows the expected impact of cooling and radiation issues on the design and outlines the need for future R&D to support the design process. A key design requirement is the need for the mechanical design and analysis to be consistent with all requirements following from the RF physics and antenna layout optimisation. As such, this paper complements that of Durodie et al [1].

  20. Adaptable Iterative and Recursive Kalman Filter Schemes

    NASA Technical Reports Server (NTRS)

    Zanetti, Renato

    2014-01-01

    Nonlinear filters are often very computationally expensive and usually not suitable for real-time applications. Real-time navigation algorithms are typically based on linear estimators, such as the extended Kalman filter (EKF) and, to a much lesser extent, the unscented Kalman filter. The Iterated Kalman filter (IKF) and the Recursive Update Filter (RUF) are two algorithms that reduce the consequences of the linearization assumption of the EKF by performing N updates for each new measurement, where N is the number of recursions, a tuning parameter. This paper introduces an adaptable RUF algorithm to calculate N on the go, a similar technique can be used for the IKF as well.

  1. The Iterated Classification Game: A New Model of the Cultural Transmission of Language

    PubMed Central

    Swarup, Samarth; Gasser, Les

    2010-01-01

    The Iterated Classification Game (ICG) combines the Classification Game with the Iterated Learning Model (ILM) to create a more realistic model of the cultural transmission of language through generations. It includes both learning from parents and learning from peers. Further, it eliminates some of the chief criticisms of the ILM: that it does not study grounded languages, that it does not include peer learning, and that it builds in a bias for compositional languages. We show that, over the span of a few generations, a stable linguistic system emerges that can be acquired very quickly by each generation, is compositional, and helps the agents to solve the classification problem with which they are faced. The ICG also leads to a different interpretation of the language acquisition process. It suggests that the role of parents is to initialize the linguistic system of the child in such a way that subsequent interaction with peers results in rapid convergence to the correct language. PMID:20190877

  2. Iterative procedure for in-situ EUV optical testing with an incoherent source

    SciTech Connect

    Miyawaka, Ryan; Naulleau, Patrick; Zakhor, Avideh

    2009-12-01

    We propose an iterative method for in-situ optical testing under partially coherent illumination that relies on the rapid computation of aerial images. In this method a known pattern is imaged with the test optic at several planes through focus. A model is created that iterates through possible aberration maps until the through-focus series of aerial images matches the experimental result. The computation time of calculating the through-focus series is significantly reduced by a-SOCS, an adapted form of the Sum Of Coherent Systems (SOCS) decomposition. In this method, the Hopkins formulation is described by an operator S which maps the space of pupil aberrations to the space of aerial images. This operator is well approximated by a truncated sum of its spectral components.

  3. Hybrid preconditioning for iterative diagonalization of ill-conditioned generalized eigenvalue problems in electronic structure calculations

    SciTech Connect

    Cai, Yunfeng; Bai, Zhaojun; Pask, John E.; Sukumar, N.

    2013-12-15

    The iterative diagonalization of a sequence of large ill-conditioned generalized eigenvalue problems is a computational bottleneck in quantum mechanical methods employing a nonorthogonal basis for ab initio electronic structure calculations. We propose a hybrid preconditioning scheme to effectively combine global and locally accelerated preconditioners for rapid iterative diagonalization of such eigenvalue problems. In partition-of-unity finite-element (PUFE) pseudopotential density-functional calculations, employing a nonorthogonal basis, we show that the hybrid preconditioned block steepest descent method is a cost-effective eigensolver, outperforming current state-of-the-art global preconditioning schemes, and comparably efficient for the ill-conditioned generalized eigenvalue problems produced by PUFE as the locally optimal block preconditioned conjugate-gradient method for the well-conditioned standard eigenvalue problems produced by planewave methods.

  4. The ITER Radial Neutron Camera Detection System

    SciTech Connect

    Marocco, D.; Belli, F.; Esposito, B.; Petrizzi, L.; Riva, M.; Bonheure, G.; Kaschuck, Y.

    2008-03-12

    A multichannel neutron detection system (Radial Neutron Camera, RNC) will be installed on the ITER equatorial port plug 1 for total neutron source strength, neutron emissivity/ion temperature profiles and n{sub t}/n{sub d} ratio measurements [1]. The system is composed by two fan shaped collimating structures: an ex-vessel structure, looking at the plasma core, containing tree sets of 12 collimators (each set lying on a different toroidal plane), and an in-vessel structure, containing 9 collimators, for plasma edge coverage. The RNC detecting system will work in a harsh environment (neutron fiux up to 10{sup 8}-10{sup 9} n/cm{sup 2} s, magnetic field >0.5 T or in-vessel detectors), should provide both counting and spectrometric information and should be flexible enough to cover the high neutron flux dynamic range expected during the different ITER operation phases. ENEA has been involved in several activities related to RNC design and optimization [2,3]. In the present paper the up-to-date design and the neutron emissivity reconstruction capabilities of the RNC will be described. Different options for detectors suitable for spectrometry and counting (e.g. scintillators and diamonds) focusing on the implications in terms of overall RNC performance will be discussed. The increase of the RNC capabilities offered by the use of new digital data acquisition systems will be also addressed.

  5. Adaptive self-calibrating iterative GRAPPA reconstruction.

    PubMed

    Park, Suhyung; Park, Jaeseok

    2012-06-01

    Parallel magnetic resonance imaging in k-space such as generalized auto-calibrating partially parallel acquisition exploits spatial correlation among neighboring signals over multiple coils in calibration to estimate missing signals in reconstruction. It is often challenging to achieve accurate calibration information due to data corruption with noises and spatially varying correlation. The purpose of this work is to address these problems simultaneously by developing a new, adaptive iterative generalized auto-calibrating partially parallel acquisition with dynamic self-calibration. With increasing iterations, under a framework of the Kalman filter spatial correlation is estimated dynamically updating calibration signals in a measurement model and using fixed-point state transition in a process model while missing signals outside the step-varying calibration region are reconstructed, leading to adaptive self-calibration and reconstruction. Noise statistic is incorporated in the Kalman filter models, yielding coil-weighted de-noising in reconstruction. Numerical and in vivo studies are performed, demonstrating that the proposed method yields highly accurate calibration and thus reduces artifacts and noises even at high acceleration. PMID:21994010

  6. Diverse Power Iteration Embeddings and Its Applications

    SciTech Connect

    Huang H.; Yoo S.; Yu, D.; Qin, H.

    2014-12-14

    Abstract—Spectral Embedding is one of the most effective dimension reduction algorithms in data mining. However, its computation complexity has to be mitigated in order to apply it for real-world large scale data analysis. Many researches have been focusing on developing approximate spectral embeddings which are more efficient, but meanwhile far less effective. This paper proposes Diverse Power Iteration Embeddings (DPIE), which not only retains the similar efficiency of power iteration methods but also produces a series of diverse and more effective embedding vectors. We test this novel method by applying it to various data mining applications (e.g. clustering, anomaly detection and feature selection) and evaluating their performance improvements. The experimental results show our proposed DPIE is more effective than popular spectral approximation methods, and obtains the similar quality of classic spectral embedding derived from eigen-decompositions. Moreover it is extremely fast on big data applications. For example in terms of clustering result, DPIE achieves as good as 95% of classic spectral clustering on the complex datasets but 4000+ times faster in limited memory environment.

  7. Iterative Gaussianization: from ICA to random rotations.

    PubMed

    Laparra, Valero; Camps-Valls, Gustavo; Malo, Jesús

    2011-04-01

    Most signal processing problems involve the challenging task of multidimensional probability density function (PDF) estimation. In this paper, we propose a solution to this problem by using a family of rotation-based iterative Gaussianization (RBIG) transforms. The general framework consists of the sequential application of a univariate marginal Gaussianization transform followed by an orthonormal transform. The proposed procedure looks for differentiable transforms to a known PDF so that the unknown PDF can be estimated at any point of the original domain. In particular, we aim at a zero-mean unit-covariance Gaussian for convenience. RBIG is formally similar to classical iterative projection pursuit algorithms. However, we show that, unlike in PP methods, the particular class of rotations used has no special qualitative relevance in this context, since looking for interestingness is not a critical issue for PDF estimation. The key difference is that our approach focuses on the univariate part (marginal Gaussianization) of the problem rather than on the multivariate part (rotation). This difference implies that one may select the most convenient rotation suited to each practical application. The differentiability, invertibility, and convergence of RBIG are theoretically and experimentally analyzed. Relation to other methods, such as radial Gaussianization, one-class support vector domain description, and deep neural networks is also pointed out. The practical performance of RBIG is successfully illustrated in a number of multidimensional problems such as image synthesis, classification, denoising, and multi-information estimation. PMID:21349790

  8. Laser cleaning of ITER's diagnostic mirrors

    NASA Astrophysics Data System (ADS)

    Skinner, C. H.; Gentile, C. A.; Doerner, R.

    2012-10-01

    Practical methods to clean ITER's diagnostic mirrors and restore reflectivity will be critical to ITER's plasma operations. We report on laser cleaning of single crystal molybdenum mirrors coated with either carbon or beryllium films 150 - 420 nm thick. A 1.06 μm Nd laser system provided 220 ns pulses at 8 kHz with typical power densities of 1-2 J/cm^2. The laser beam was fiber optically coupled to a scanner suitable for tokamak applications. The efficacy of mirror cleaning was assessed with a new technique that combines microscopic imaging and reflectivity measurements [1]. The method is suitable for hazardous materials such as beryllium as the mirrors remain sealed in a vacuum chamber. Excellent restoration of reflectivity for the carbon coated Mo mirrors was observed after laser scanning under vacuum conditions. For the beryllium coated mirrors restoration of reflectivity has so far been incomplete and modeling indicates that a shorter duration laser pulse is needed. No damage of the molybdenum mirror substrates was observed.[4pt][1] C.H. Skinner et al., Rev. Sci. Instrum. at press.

  9. Ordinal neural networks without iterative tuning.

    PubMed

    Fernández-Navarro, Francisco; Riccardi, Annalisa; Carloni, Sante

    2014-11-01

    Ordinal regression (OR) is an important branch of supervised learning in between the multiclass classification and regression. In this paper, the traditional classification scheme of neural network is adapted to learn ordinal ranks. The model proposed imposes monotonicity constraints on the weights connecting the hidden layer with the output layer. To do so, the weights are transcribed using padding variables. This reformulation leads to the so-called inequality constrained least squares (ICLS) problem. Its numerical solution can be obtained by several iterative methods, for example, trust region or line search algorithms. In this proposal, the optimum is determined analytically according to the closed-form solution of the ICLS problem estimated from the Karush-Kuhn-Tucker conditions. Furthermore, following the guidelines of the extreme learning machine framework, the weights connecting the input and the hidden layers are randomly generated, so the final model estimates all its parameters without iterative tuning. The model proposed achieves competitive performance compared with the state-of-the-art neural networks methods for OR. PMID:25330430

  10. Nuclear Analysis of an ITER Blanket Module

    NASA Astrophysics Data System (ADS)

    Chiovaro, P.; Di Maio, P. A.; Parrinello, V.

    2013-08-01

    ITER blanket system is the reactor's plasma-facing component, it is mainly devoted to provide the thermal and nuclear shielding of the Vacuum Vessel and external ITER components, being intended also to act as plasma limiter. It consists of 440 individual modules which are located in the inboard, upper and outboard regions of the reactor. In this paper attention has been focused on to a single outboard blanket module located in the equatorial zone, whose nuclear response under irradiation has been investigated following a numerical approach based on the Monte Carlo method and adopting the MCNP5 code. The main features of this blanket module nuclear behaviour have been determined, paying particular attention to energy and spatial distribution of the neutron flux and deposited nuclear power together with the spatial distribution of its volumetric density. Moreover, the neutronic damage of the structural material has also been investigated through the evaluation of displacement per atom and helium and hydrogen production rates. Finally, an activation analysis has been performed with FISPACT inventory code using, as input, the evaluated neutron spectrum to assess the module specific activity and contact dose rate after irradiation under a specific operating scenario.

  11. Iterative CBCT reconstruction using Hessian penalty

    NASA Astrophysics Data System (ADS)

    Sun, Tao; Sun, Nanbo; Wang, Jing; Tan, Shan

    2015-03-01

    Statistical iterative reconstruction algorithms have shown potential to improve cone-beam CT (CBCT) image quality. Most iterative reconstruction algorithms utilize prior knowledge as a penalty term in the objective function. The penalty term greatly affects the performance of a reconstruction algorithm. The total variation (TV) penalty has demonstrated great ability in suppressing noise and improving image quality. However, calculated from the first-order derivatives, the TV penalty leads to the well-known staircase effect, which sometimes makes the reconstructed images oversharpen and unnatural. In this study, we proposed to use a second-order derivative penalty that involves the Frobenius norm of the Hessian matrix of an image for CBCT reconstruction. The second-order penalty retains some of the most favorable properties of the TV penalty like convexity, homogeneity, and rotation and translation invariance, and has a better ability in preserving the structures of gradual transition in the reconstructed images. An effective algorithm was developed to minimize the objective function with the majorization-minimization (MM) approach. The experiments on a digital phantom and two physical phantoms demonstrated the priority of the proposed penalty, particularly in suppressing the staircase effect of the TV penalty.

  12. Thomson scattering diagnostic systems in ITER

    NASA Astrophysics Data System (ADS)

    Bassan, M.; Andrew, P.; Kurskiev, G.; Mukhin, E.; Hatae, T.; Vayakis, G.; Yatsuka, E.; Walsh, M.

    2016-01-01

    Thomson scattering (TS) is a proven diagnostic technique that will be implemented in ITER in three independent systems. The Edge TS will measure electron temperature Te and electron density ne profiles at high resolution in the region with r/a>0.8 (with a the minor radius). The Core TS will cover the region r/a<0.85 and shall be able to measure electron temperatures up to 40 keV . The Divertor TS will observe a segment of the divertor plasma more than 700 mm long and is designed to detect Te as low as 0.3 eV . The Edge and Core systems are primary contributors to Te and ne profiles. Both are installed in equatorial port 10 and very close together with the toroidal distance between the two laser beams of less than 600 mm at the first wall (~ 6° toroidal separation), a characteristic that should allow to reliably match the two profiles in the region 0.8ITER environment is imposing specific loads (e.g. gamma and neutron radiation, temperatures, disruption-induced stresses) and also access and reliability constraints that require new designs for many of the sub-systems. The challenges and the proposed solutions for all three TS systems are presented.

  13. Iterative reconstruction of volumetric particle distribution

    NASA Astrophysics Data System (ADS)

    Wieneke, Bernhard

    2013-02-01

    For tracking the motion of illuminated particles in space and time several volumetric flow measurement techniques are available like 3D-particle tracking velocimetry (3D-PTV) recording images from typically three to four viewing directions. For higher seeding densities and the same experimental setup, tomographic PIV (Tomo-PIV) reconstructs voxel intensities using an iterative tomographic reconstruction algorithm (e.g. multiplicative algebraic reconstruction technique, MART) followed by cross-correlation of sub-volumes computing instantaneous 3D flow fields on a regular grid. A novel hybrid algorithm is proposed here that similar to MART iteratively reconstructs 3D-particle locations by comparing the recorded images with the projections calculated from the particle distribution in the volume. But like 3D-PTV, particles are represented by 3D-positions instead of voxel-based intensity blobs as in MART. Detailed knowledge of the optical transfer function and the particle image shape is mandatory, which may differ for different positions in the volume and for each camera. Using synthetic data it is shown that this method is capable of reconstructing densely seeded flows up to about 0.05 ppp with similar accuracy as Tomo-PIV. Finally the method is validated with experimental data.

  14. Adaptive self-calibrating iterative GRAPPA reconstruction.

    PubMed

    Park, Suhyung; Park, Jaeseok

    2012-06-01

    Parallel magnetic resonance imaging in k-space such as generalized auto-calibrating partially parallel acquisition exploits spatial correlation among neighboring signals over multiple coils in calibration to estimate missing signals in reconstruction. It is often challenging to achieve accurate calibration information due to data corruption with noises and spatially varying correlation. The purpose of this work is to address these problems simultaneously by developing a new, adaptive iterative generalized auto-calibrating partially parallel acquisition with dynamic self-calibration. With increasing iterations, under a framework of the Kalman filter spatial correlation is estimated dynamically updating calibration signals in a measurement model and using fixed-point state transition in a process model while missing signals outside the step-varying calibration region are reconstructed, leading to adaptive self-calibration and reconstruction. Noise statistic is incorporated in the Kalman filter models, yielding coil-weighted de-noising in reconstruction. Numerical and in vivo studies are performed, demonstrating that the proposed method yields highly accurate calibration and thus reduces artifacts and noises even at high acceleration.

  15. Iterative image reconstruction in spectral CT

    NASA Astrophysics Data System (ADS)

    Hernandez, Daniel; Michel, Eric; Kim, Hye S.; Kim, Jae G.; Han, Byung H.; Cho, Min H.; Lee, Soo Y.

    2012-03-01

    Scan time of spectral-CTs is much longer than conventional CTs due to limited number of x-ray photons detectable by photon-counting detectors. However, the spectral pixel information in spectral-CT has much richer information on physiological and pathological status of the tissues than the CT-number in conventional CT, which makes the spectral- CT one of the promising future imaging modalities. One simple way to reduce the scan time in spectral-CT imaging is to reduce the number of views in the acquisition of projection data. But, this may result in poorer SNR and strong streak artifacts which can severely compromise the image quality. In this work, spectral-CT projection data were obtained from a lab-built spectral-CT consisting of a single CdTe photon counting detector, a micro-focus x-ray tube and scan mechanics. For the image reconstruction, we used two iterative image reconstruction methods, the simultaneous iterative reconstruction technique (SIRT) and the total variation minimization based on conjugate gradient method (CG-TV), along with the filtered back-projection (FBP) to compare the image quality. From the imaging of the iodine containing phantoms, we have observed that SIRT and CG-TV are superior to the FBP method in terms of SNR and streak artifacts.

  16. Critical Assessment of Pressure Gauges for ITER

    SciTech Connect

    Tabares, Francisco L.; Tafalla, David; Garcia-Cortes, Isabel

    2008-03-12

    The density and flux of molecular species in ITER, largely dominated by the molecular form of the main plasma components and the He ash, is a valuable parameter of relevance not only for operation purposes but also for validating existing neutral particle models of direct implications in divertor performance. An accurate and spatially resolved monitoring of this parameter implies the proper selection of pressure gauges able to cope with the very unique and aggressive environment to be expected in a fusion reactor. To date, there is no standard gauge fulfilling all the requirements, which encompass high neutron and gamma fluxes, together with strong magnetic field and temperature excursions and dusty environment. In the present work, a review of the challenges to face in the measurement of neutral pressure in ITER, together with existing technologies and developments to be made in some of them for their application to the task is presented. Particular attention is paid to R and D needs of existing concepts with potential use in future designs.

  17. The role of heating and current drive in ITER

    SciTech Connect

    Nevins, W.M.; Haney, S.

    1993-10-18

    This report discusses and summarize the role of heating and non-inductive current drive in ITER as: (1) ITER must have heating power sufficient for ignition. (2) The heating system must be capable of current drive. (3) Steady-state operation is an ``ultimate goal.`` It is recognized that additional heating and current drive power (beyond what is initially installed on ITER) may be required. (4) The ``Ultimate goal of steady-state operation`` means steady-state with Q{sub CD} {ge} 5. Unlike the ``Terms of Reference`` for the ITER CDA, the ``ITER Technical Objectives and Approaches`` for the EDA sets no goal for the neutron wall load during steady-state operation. (5) In addition to bulk current drive, the ITER heating and current drive system should be used for current profile control and for burn control.

  18. A unified noise analysis for iterative image estimation

    SciTech Connect

    Qi, Jinyi

    2003-07-03

    Iterative image estimation methods have been widely used in emission tomography. Accurate estimate of the uncertainty of the reconstructed images is essential for quantitative applications. While theoretical approach has been developed to analyze the noise propagation from iteration to iteration, the current results are limited to only a few iterative algorithms that have an explicit multiplicative update equation. This paper presents a theoretical noise analysis that is applicable to a wide range of preconditioned gradient type algorithms. One advantage is that proposed method does not require an explicit expression of the preconditioner and hence it is applicable to some algorithms that involve line searches. By deriving fixed point expression from the iteration based results, we show that the iteration based noise analysis is consistent with the xed point based analysis. Examples in emission tomography and transmission tomography are shown.

  19. Deep Brain Stimulation using Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Jiles, David; Williams, Paul; Crowther, Lawrence; Iowa State University Team; Wolfson CentreMagnetics Team

    2011-03-01

    New applications for transcranial magnetic stimulation are developing rapidly for both diagnostic and therapeutic purposes. Therefore so is the demand for improved performance, particularly in terms of their ability to stimulate deeper regions of the brain and to do so selectively. The coil designs that are used presently are limited in their ability to stimulate the brain at depth and with high spatial focality. Consequently, any improvement in coil performance would have a significant impact in extending the usefulness of TMS in both clinical applications and academic research studies. New and improved coil designs have then been developed, modeled and tested as a result of this work. A large magnetizing coil, 300mm in diameter and compatible with a commercial TMS system has been constructed to determine its feasibility for use as a deep brain stimulator. The results of this work have suggested directions that could be pursued in order to further improve the coil designs.

  20. A Novel Iterative Scheme and Its Application to Differential Equations

    PubMed Central

    Khan, Yasir; Naeem, F.; Šmarda, Zdeněk

    2014-01-01

    The purpose of this paper is to employ an alternative approach to reconstruct the standard variational iteration algorithm II proposed by He, including Lagrange multiplier, and to give a simpler formulation of Adomian decomposition and modified Adomian decomposition method in terms of newly proposed variational iteration method-II (VIM). Through careful investigation of the earlier variational iteration algorithm and Adomian decomposition method, we find unnecessary calculations for Lagrange multiplier and also repeated calculations involved in each iteration, respectively. Several examples are given to verify the reliability and efficiency of the method. PMID:24757427

  1. ITER Cryoplant Status and Economics of the LHe plants

    NASA Astrophysics Data System (ADS)

    Monneret, E.; Chalifour, M.; Bonneton, M.; Fauve, E.; Voigt, T.; Badgujar, S.; Chang, H.-S.; Vincent, G.

    The ITER cryoplant is composed of helium and nitrogen refrigerators and generator combined with 80 K helium loop plants and external purification systems. Storage and recovery of the helium inventory is provided in warm and cold (80 K and 4.5 K) helium tanks.The conceptual design of the ITER cryoplant has been completed, the technical requirements defined for industrial procurement and contracts signed with industry. Each contract covers the design, manufacturing, installation and commissioning. Design is under finalization and manufacturing has started. First deliveries are scheduled by end of 2015.The various cryoplant systems are designed based on recognized codes and international standards to meet the availability, the reliability and the time between maintenance imposed by the long-term uninterrupted operation of the ITER Tokamak. In addition, ITER has to consider the constraint of a nuclear installation.ITER Organization (IO) is responsible for the liquid helium (LHe) Plants contract signed end of 2012 with industry. It is composed of three LHe Plants, working in parallel and able to provide a total average cooling capacity of 75 kW at 4.5 K. Based on concept designed developed with industries and the procurement phase, ITER has accumulated data to broaden the scaling laws for costing such systems.After describing the status of ITER cryoplant part of the cryogenic system, we shall present the economics of the ITER LHe Plants based on key design requirements, choice and challenges of this ITER Organization procurement.

  2. Optimal parameters for linear second-degree stationary iterative methods

    SciTech Connect

    Manteuffel, T. A.

    1980-11-01

    It is shown that the optimal parameters for linear second-degree stationary iterative methods applied to nonsymmetric linear systems can be found by solving the same minimax problem used to find optimal parameters for the Tchebychev iteration. In fact, the Tchebychev iteration is asymptotically equivalent to a linear second-degree stationary method. The method of finding optimal parameters for the Tchebychev iteration given by Manteuffel (Numer. Math., 28, 307-27 (1977)) can be used to find optimal parameters for the stationary method as well. 1 figure.

  3. A synopsis of collective alpha effects and implications for ITER

    SciTech Connect

    Sigmar, D.J.

    1990-10-01

    This paper discusses the following: Alpha Interaction with Toroidal Alfven Eigenmodes; Alpha Interaction with Ballooning Modes; Alpha Interaction with Fishbone Oscillations; and Implications for ITER.

  4. Unsupervised iterative detection of land mines in highly cluttered environments.

    PubMed

    Batman, Sinan; Goutsias, John

    2003-01-01

    An unsupervised iterative scheme is proposed for land mine detection in heavily cluttered scenes. This scheme is based on iterating hybrid multispectral filters that consist of a decorrelating linear transform coupled with a nonlinear morphological detector. Detections extracted from the first pass are used to improve results in subsequent iterations. The procedure stops after a predetermined number of iterations. The proposed scheme addresses several weaknesses associated with previous adaptations of morphological approaches to land mine detection. Improvement in detection performance, robustness with respect to clutter inhomogeneities, a completely unsupervised operation, and computational efficiency are the main highlights of the method. Experimental results reveal excellent performance.

  5. Bounded-Angle Iterative Decoding of LDPC Codes

    NASA Technical Reports Server (NTRS)

    Dolinar, Samuel; Andrews, Kenneth; Pollara, Fabrizio; Divsalar, Dariush

    2009-01-01

    Bounded-angle iterative decoding is a modified version of conventional iterative decoding, conceived as a means of reducing undetected-error rates for short low-density parity-check (LDPC) codes. For a given code, bounded-angle iterative decoding can be implemented by means of a simple modification of the decoder algorithm, without redesigning the code. Bounded-angle iterative decoding is based on a representation of received words and code words as vectors in an n-dimensional Euclidean space (where n is an integer).

  6. Peripheral nerve stimulation: definition.

    PubMed

    Abejón, David; Pérez-Cajaraville, Juan

    2011-01-01

    Recently, there has been a tremendous evolution in the field of neurostimulation, both from the technological point of view and from development of the new and different indications. In some areas, such as peripheral nerve stimulation, there has been a boom in recent years due to the variations in the surgical technique and the improved results documented by in multiple published papers. All this makes imperative the need to classify and define the different types of stimulation that are used today. The confusion arises when attempting to describe peripheral nerve stimulation and subcutaneous stimulation. Peripheral nerve stimulation, in its pure definition, involves implanting a lead on a nerve, with the aim to produce paresthesia along the entire trajectory of the stimulated nerve.

  7. Stimulant Use Disorders.

    PubMed

    Park, Taryn M; Haning, William F

    2016-07-01

    Compared with other illicit substances, stimulants are not commonly used by adolescents; however, they represent a serious concern regarding substance use among youths. This article uses methamphetamine as a model for stimulant use in adolescents; cocaine and prescription stimulants are also mentioned. Methamphetamine use among adolescents and young adults is a serious health concern with potentially long-term physical, cognitive, and psychiatric consequences. Brain development and the effects of misusing stimulants align such that usage in adolescents can more dangerous than during adulthood. It seems helpful to keep in mind the differences between adolescents and young adults when implementing interventions. PMID:27338967

  8. Some results concerning linear iterative (systolic) arrays

    SciTech Connect

    Ibarra, O.H.; Palis, M.A.; Kim, S.M.

    1985-05-01

    The authors have shown some new interesting results concerning the properties, power, and limitations of various types of linear iterative (systolic) arrays. The method they employed consisted of finding sequential machine characterizations of these array models, and then using the characterizations to prove the results. Because of the absence of any concurrency and synchronization problems, the authors obtained simple proofs to results which when proved directly on the arrays would seem very difficult. The characterizations, therefore, provide a novel and promising method which can be used to analyze other systolic systems. In the future they hope to extend this methodology to the study of two-dimensional and multidimensional systolic arrays, and other systolic systems with different interconnection networks.

  9. Structural analysis of ITER magnet feeders

    SciTech Connect

    Ilyin, Yuri; Gung, Chen-Yu; Bauer, Pierre; Chen, Yonghua; Jong, Cornelis; Devred, Arnaud; Mitchell, Neil; Lorriere, Philippe; Farek, Jaromir; Nannini, Matthieu

    2012-06-15

    This paper summarizes the results of the static structural analyses, which were conducted in support of the ITER magnet feeder design with the aim of validating certain components against the structural design criteria. While almost every feeder has unique features, they all share many common constructional elements and the same functional specifications. The analysis approach to assess the load conditions and stresses that have driven the design is equivalent for all feeders, except for particularities that needed to be modeled in each case. The mechanical analysis of the feeders follows the sub-modeling approach: the results of the global mechanical model of a feeder assembly are used as input for the detailed models of the feeder' sub-assemblies or single components. Examples of such approach, including the load conditions, stress assessment criteria and solutions for the most critical components, are discussed. It has been concluded that the feeder system is safe in the referential operation scenarios. (authors)

  10. Iterative methods for Toeplitz-like matrices

    SciTech Connect

    Huckle, T.

    1994-12-31

    In this paper the author will give a survey on iterative methods for solving linear equations with Toeplitz matrices, Block Toeplitz matrices, Toeplitz plus Hankel matrices, and matrices with low displacement rank. He will treat the following subjects: (1) optimal (w)-circulant preconditioners is a generalization of circulant preconditioners; (2) Optimal implementation of circulant-like preconditioners in the complex and real case; (3) preconditioning of near-singular matrices; what kind of preconditioners can be used in this case; (4) circulant preconditioning for more general classes of Toeplitz matrices; what can be said about matrices with coefficients that are not l{sub 1}-sequences; (5) preconditioners for Toeplitz least squares problems, for block Toeplitz matrices, and for Toeplitz plus Hankel matrices.

  11. Exact iterative reconstruction for the interior problem

    PubMed Central

    Zeng, Gengsheng L; Gullberg, Grant T

    2010-01-01

    There is a trend in single photon emission computed tomography (SPECT) that small and dedicated imaging systems are becoming popular. For example, many companies are developing small dedicated cardiac SPECT systems with different designs. These dedicated systems have a smaller field of view (FOV) than a full-size clinical system. Thus data truncation has become the norm rather than the exception in these systems. Therefore, it is important to develop region of interest (ROI) reconstruction algorithms using truncated data. This paper is a stepping stone toward this direction. This paper shows that the common generic iterative image reconstruction algorithms are able to exactly reconstruct the ROI under the conditions that the convex ROI is fully sampled and the image value in a sub-region within the ROI is known. If the ROI includes a sub-region that is outside the patient body, then the conditions can be easily satisfied. PMID:19741279

  12. ITER CENTRAL SOLENOID COIL INSULATION QUALIFICATION

    SciTech Connect

    Martovetsky, N N; Mann, T L; Miller, J R; Freudenberg, K D; Reed, R P; Walsh, R P; McColskey, J D; Evans, D

    2009-06-11

    An insulation system for ITER Central Solenoid must have sufficiently high electrical and structural strength. Design efforts to bring stresses in the turn and layer insulation within allowables failed. It turned out to be impossible to eliminate high local tensile stresses in the winding pack. When high local stresses can not be designed out, the qualification procedure requires verification of the acceptable structural and electrical strength by testing. We built two 4 x 4 arrays of the conductor jacket with two options of the CS insulation and subjected the arrays to 1.2 million compressive cycles at 60 MPa and at 76 K. Such conditions simulated stresses in the CS insulation. We performed voltage withstand tests and after end of cycling we measured the breakdown voltages between in the arrays. After that we dissectioned the arrays and studied micro cracks in the insulation. We report details of the specimens preparation, test procedures and test results.

  13. Robust tooth surface reconstruction by iterative deformation.

    PubMed

    Jiang, Xiaotong; Dai, Ning; Cheng, Xiaosheng; Wang, Jun; Peng, Qingjin; Liu, Hao; Cheng, Cheng

    2016-01-01

    Digital design technologies have been applied extensively in dental medicine, especially in the field of dental restoration. The all-ceramic crown is an important restoration type of dental CAD systems. This paper presents a robust tooth surface reconstruction algorithm for all-ceramic crown design. The algorithm involves three necessary steps: standard tooth initial positioning and division; salient feature point extraction using Morse theory; and standard tooth deformation using iterative Laplacian Surface Editing and mesh stitching. This algorithm can retain the morphological features of the tooth surface well. It is robust and suitable for almost all types of teeth, including incisor, canine, premolar, and molar. Moreover, it allows dental technicians to use their own preferred library teeth for reconstruction. The algorithm has been successfully integrated in our Dental CAD system, more than 1000 clinical cases have been tested to demonstrate the robustness and effectiveness of the proposed algorithm.

  14. Iterative restoration of SPECT projection images

    SciTech Connect

    Glick, S.J.; Xia, W.

    1997-04-01

    Photon attenuation and the limited nonstationary spatial resolution of the detector can reduce both qualitative and quantitative image quality in single photon emission computed tomography (SPECT). In this paper, a reconstruction approach is described which can compensate for both of these degradations. The approach involves processing the project data with Bellini`s method for attenuation compensation followed by an iterative deconvolution technique which uses the frequency distance principle (FDP) to model the distance-dependent camera blur. Modeling of the camera blur with the FDP allows an efficient implementation using fast Fourier transformation (FFT) methods. After processing of the project data, reconstruction is performed using filtered backprojections. Simulation studies using two different brain phantoms show that this approach gives reconstructions with a favorable bias versus noise tradeoff, provides no visually undesirable noise artifacts, and requires a low computational load.

  15. Iterated Gate Teleportation and Blind Quantum Computation.

    PubMed

    Pérez-Delgado, Carlos A; Fitzsimons, Joseph F

    2015-06-01

    Blind quantum computation allows a user to delegate a computation to an untrusted server while keeping the computation hidden. A number of recent works have sought to establish bounds on the communication requirements necessary to implement blind computation, and a bound based on the no-programming theorem of Nielsen and Chuang has emerged as a natural limiting factor. Here we show that this constraint only holds in limited scenarios, and show how to overcome it using a novel method of iterated gate teleportations. This technique enables drastic reductions in the communication required for distributed quantum protocols, extending beyond the blind computation setting. Applied to blind quantum computation, this technique offers significant efficiency improvements, and in some scenarios offers an exponential reduction in communication requirements. PMID:26196609

  16. Learning to improve iterative repair scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte; Davis, Eugene

    1992-01-01

    This paper presents a general learning method for dynamically selecting between repair heuristics in an iterative repair scheduling system. The system employs a version of explanation-based learning called Plausible Explanation-Based Learning (PEBL) that uses multiple examples to confirm conjectured explanations. The basic approach is to conjecture contradictions between a heuristic and statistics that measure the quality of the heuristic. When these contradictions are confirmed, a different heuristic is selected. To motivate the utility of this approach we present an empirical evaluation of the performance of a scheduling system with respect to two different repair strategies. We show that the scheduler that learns to choose between the heuristics outperforms the same scheduler with any one of two heuristics alone.

  17. Iterative Precise Conductivity Measurement with IDEs.

    PubMed

    Hubálek, Jaromír

    2015-05-22

    The paper presents a new approach in the field of precise electrolytic conductivity measurements with planar thin- and thick-film electrodes. This novel measuring method was developed for measurement with comb-like electrodes called interdigitated electrodes (IDEs). Correction characteristics over a wide range of specific conductivities were determined from an interface impedance characterization of the thick-film IDEs. The local maximum of the capacitive part of the interface impedance is used for corrections to get linear responses. The measuring frequency was determined at a wide range of measured conductivity. An iteration mode of measurements was suggested to precisely measure the conductivity at the right frequency in order to achieve a highly accurate response. The method takes precise conductivity measurements in concentration ranges from 10(-6) to 1 M without electrode cell replacement.

  18. ITER L-Mode Confinement Database

    SciTech Connect

    S.M. Kaye and the ITER Confinement Database Working Group

    1997-10-01

    This paper describes the content of an L-mode database that has been compiled with data from Alcator C-Mod, ASDEX, DIII, DIII-D, FTU, JET, JFT-2M, JT-60, PBX-M, PDX, T-10, TEXTOR, TFTR, and Tore-Supra. The database consists of a total of 2938 entries, 1881 of which are in the L-phase while 922 are ohmically heated (OH) only. Each entry contains up to 95 descriptive parameters, including global and kinetic information, machine conditioning, and configuration. The paper presents a description of the database and the variables contained therein, and it also presents global and thermal scalings along with predictions for ITER. The L-mode thermal confinement time scaling was determined from a subset of 1312 entries for which the thermal confinement time scaling was provided.

  19. ITER L-mode confinement database

    SciTech Connect

    Kaye, S.M.

    1997-10-06

    This paper describes the content of an L-mode database that has been compiled with data from Alcator C-Mod, ASDEX, DIII, DIII-D, FTU, JET, JFT-2M, JT-60, PBX-M, PDX, T-10, TEXTOR, TFTR, and Tore-Supra. The database consists of a total of 2938 entries, 1881 of which are in the L-phase while 922 are ohmically heated only (OH). Each entry contains up to 95 descriptive parameters, including global and kinetic information, machine conditioning, and configuration. The paper presents a description of the database and the variables contained therein, and it also presents global and thermal scalings along with predictions for ITER.

  20. Generating fracture networks using iterated function systems

    NASA Astrophysics Data System (ADS)

    Mohrlok, U.; Liedl, R.

    In order to model flow and transport in fractured rocks it is important to know the geometry of the fracture network. A stochastic approach is commonly used to generate a synthetic fracture network from the statistics measured at a natural fracture network. The approach presented herein is able to incorporate the structures found in a natural fracture network into the synthetic fracture network. These synthetic fracture networks are the images generated by Iterated Function Systems (IFS) as introduced by Barnsley (1988). The conditions these IFS have to fulfil to determine images resembling fracture networks and the effects of their parameters on the images are discussed. It is possible to define the parameters of the IFS in order to generate some properties of a fracture network. The image of an IFS consists of many single points and has to be suitably processed for further use.

  1. Orbit of an image under iterated system

    NASA Astrophysics Data System (ADS)

    Singh, S. L.; Mishra, S. N.; Jain, Sarika

    2011-03-01

    An orbital picture depicts the path of an object under semi-group of transformations. The concept initially given by Barnsley [3] has utmost importance in image compression, biological modeling and other areas of fractal geometry. In this paper, we introduce superior iterations to study the role of linear and nonlinear transformations on the orbit of an object. Various characteristics of the computed figures have been discussed to indicate the usefulness of study in mathematical analysis. Modified algorithms are given to compute the orbital picture and V-variable orbital picture. An algorithm to calculate the distance between images makes the study motivating. A brief discussion about the proof of the Cauchy sequence of images is also given.

  2. Generating fracture networks using iterated function systems

    NASA Astrophysics Data System (ADS)

    Mohrlok, U.; Liedl, R.

    1996-03-01

    In order to model flow and transport in fractured rocks it is important to know the geometry of the fracture network. A stochastic approach is commonly used to generate a synthetic fracture network from the statistics measured at a natural fracture network. The approach presented herein is able to incorporate the structures found in a natural fracture network into the synthetic fracture network. These synthetic fracture networks are the images generated by Iterated Function Systems (IFS) as introduced by Barnsley (1988). The conditions these IFS have to fulfil to determine images resembling fracture networks and the effects of their parameters on the images are discussed. It is possible to define the parameters of the IFS in order to generate some properties of a fracture network. The image of an IFS consists of many single points and has to be suitably processed for further use.

  3. Iterated Gate Teleportation and Blind Quantum Computation.

    PubMed

    Pérez-Delgado, Carlos A; Fitzsimons, Joseph F

    2015-06-01

    Blind quantum computation allows a user to delegate a computation to an untrusted server while keeping the computation hidden. A number of recent works have sought to establish bounds on the communication requirements necessary to implement blind computation, and a bound based on the no-programming theorem of Nielsen and Chuang has emerged as a natural limiting factor. Here we show that this constraint only holds in limited scenarios, and show how to overcome it using a novel method of iterated gate teleportations. This technique enables drastic reductions in the communication required for distributed quantum protocols, extending beyond the blind computation setting. Applied to blind quantum computation, this technique offers significant efficiency improvements, and in some scenarios offers an exponential reduction in communication requirements.

  4. Iterated upwind schemes for gas dynamics

    SciTech Connect

    Smolarkiewicz, Piotr K. Szmelter, Joanna

    2009-01-10

    A class of high-resolution schemes established in integration of anelastic equations is extended to fully compressible flows, and documented for unsteady (and steady) problems through a span of Mach numbers from zero to supersonic. The schemes stem from iterated upwind technology of the multidimensional positive definite advection transport algorithm (MPDATA). The derived algorithms employ standard and modified forms of the equations of gas dynamics for conservation of mass, momentum and either total or internal energy as well as potential temperature. Numerical examples from elementary wave propagation, through computational aerodynamics benchmarks, to atmospheric small- and large-amplitude acoustics with intricate wave-flow interactions verify the approach for both structured and unstructured meshes, and demonstrate its flexibility and robustness.

  5. Electronic noise modeling in statistical iterative reconstruction.

    PubMed

    Xu, Jingyan; Tsui, Benjamin M W

    2009-06-01

    We consider electronic noise modeling in tomographic image reconstruction when the measured signal is the sum of a Gaussian distributed electronic noise component and another random variable whose log-likelihood function satisfies a certain linearity condition. Examples of such likelihood functions include the Poisson distribution and an exponential dispersion (ED) model that can approximate the signal statistics in integration mode X-ray detectors. We formulate the image reconstruction problem as a maximum-likelihood estimation problem. Using an expectation-maximization approach, we demonstrate that a reconstruction algorithm can be obtained following a simple substitution rule from the one previously derived without electronic noise considerations. To illustrate the applicability of the substitution rule, we present examples of a fully iterative reconstruction algorithm and a sinogram smoothing algorithm both in transmission CT reconstruction when the measured signal contains additive electronic noise. Our simulation studies show the potential usefulness of accurate electronic noise modeling in low-dose CT applications.

  6. Nuclear Forensic Inferences Using Iterative Multidimensional Statistics

    SciTech Connect

    Robel, M; Kristo, M J; Heller, M A

    2009-06-09

    Nuclear forensics involves the analysis of interdicted nuclear material for specific material characteristics (referred to as 'signatures') that imply specific geographical locations, production processes, culprit intentions, etc. Predictive signatures rely on expert knowledge of physics, chemistry, and engineering to develop inferences from these material characteristics. Comparative signatures, on the other hand, rely on comparison of the material characteristics of the interdicted sample (the 'questioned sample' in FBI parlance) with those of a set of known samples. In the ideal case, the set of known samples would be a comprehensive nuclear forensics database, a database which does not currently exist. In fact, our ability to analyze interdicted samples and produce an extensive list of precise materials characteristics far exceeds our ability to interpret the results. Therefore, as we seek to develop the extensive databases necessary for nuclear forensics, we must also develop the methods necessary to produce the necessary inferences from comparison of our analytical results with these large, multidimensional sets of data. In the work reported here, we used a large, multidimensional dataset of results from quality control analyses of uranium ore concentrate (UOC, sometimes called 'yellowcake'). We have found that traditional multidimensional techniques, such as principal components analysis (PCA), are especially useful for understanding such datasets and drawing relevant conclusions. In particular, we have developed an iterative partial least squares-discriminant analysis (PLS-DA) procedure that has proven especially adept at identifying the production location of unknown UOC samples. By removing classes which fell far outside the initial decision boundary, and then rebuilding the PLS-DA model, we have consistently produced better and more definitive attributions than with a single pass classification approach. Performance of the iterative PLS-DA method

  7. Error bounds from extra precise iterative refinement

    SciTech Connect

    Demmel, James; Hida, Yozo; Kahan, William; Li, Xiaoye S.; Mukherjee, Soni; Riedy, E. Jason

    2005-02-07

    We present the design and testing of an algorithm for iterative refinement of the solution of linear equations, where the residual is computed with extra precision. This algorithm was originally proposed in the 1960s [6, 22] as a means to compute very accurate solutions to all but the most ill-conditioned linear systems of equations. However two obstacles have until now prevented its adoption in standard subroutine libraries like LAPACK: (1) There was no standard way to access the higher precision arithmetic needed to compute residuals, and (2) it was unclear how to compute a reliable error bound for the computed solution. The completion of the new BLAS Technical Forum Standard [5] has recently removed the first obstacle. To overcome the second obstacle, we show how a single application of iterative refinement can be used to compute an error bound in any norm at small cost, and use this to compute both an error bound in the usual infinity norm, and a componentwise relative error bound. We report extensive test results on over 6.2 million matrices of dimension 5, 10, 100, and 1000. As long as a normwise (resp. componentwise) condition number computed by the algorithm is less than 1/max{l_brace}10,{radical}n{r_brace} {var_epsilon}{sub w}, the computed normwise (resp. componentwise) error bound is at most 2 max{l_brace}10,{radical}n{r_brace} {center_dot} {var_epsilon}{sub w}, and indeed bounds the true error. Here, n is the matrix dimension and w is single precision roundoff error. For worse conditioned problems, we get similarly small correct error bounds in over 89.4% of cases.

  8. An iterative subaperture position correction algorithm

    NASA Astrophysics Data System (ADS)

    Lo, Weng-Hou; Lin, Po-Chih; Chen, Yi-Chun

    2015-08-01

    The subaperture stitching interferometry is a technique suitable for testing high numerical-aperture optics, large-diameter spherical lenses and aspheric optics. In the stitching process, each subaperture has to be placed at its correct position in a global coordinate, and the positioning precision would affect the accuracy of stitching result. However, the mechanical limitations in the alignment process as well as vibrations during the measurement would induce inevitable subaperture position uncertainties. In our previous study, a rotational scanning subaperture stitching interferometer has been constructed. This paper provides an iterative algorithm to correct the subaperture position without altering the interferometer configuration. Each subaperture is first placed at its geometric position estimated according to the F number of reference lens, the measurement zenithal angle and the number of pixels along the width of subaperture. By using the concept of differentiation, a shift compensator along the radial direction of the global coordinate is added into the stitching algorithm. The algorithm includes two kinds of compensators: one for the geometric null with four compensators of piston, two directional tilts and defocus, and the other for the position correction with the shift compensator. These compensators are computed iteratively to minimize the phase differences in the overlapped regions of subapertures in a least-squares sense. The simulation results demonstrate that the proposed method works to the position accuracy of 0.001 pixels for both the single-ring and multiple-ring configurations. Experimental verifications with the single-ring and multiple-ring data also show the effectiveness of the algorithm.

  9. Iterative build OMIT maps: Map improvement by iterative model-building and refinement without model bias

    SciTech Connect

    Los Alamos National Laboratory, Mailstop M888, Los Alamos, NM 87545, USA; Lawrence Berkeley National Laboratory, One Cyclotron Road, Building 64R0121, Berkeley, CA 94720, USA; Department of Haematology, University of Cambridge, Cambridge CB2 0XY, England; Terwilliger, Thomas; Terwilliger, T.C.; Grosse-Kunstleve, Ralf Wilhelm; Afonine, P.V.; Moriarty, N.W.; Zwart, P.H.; Hung, L.-W.; Read, R.J.; Adams, P.D.

    2008-02-12

    A procedure for carrying out iterative model-building, density modification and refinement is presented in which the density in an OMIT region is essentially unbiased by an atomic model. Density from a set of overlapping OMIT regions can be combined to create a composite 'Iterative-Build' OMIT map that is everywhere unbiased by an atomic model but also everywhere benefiting from the model-based information present elsewhere in the unit cell. The procedure may have applications in the validation of specific features in atomic models as well as in overall model validation. The procedure is demonstrated with a molecular replacement structure and with an experimentally-phased structure, and a variation on the method is demonstrated by removing model bias from a structure from the Protein Data Bank.

  10. An application generator for rapid prototyping of Ada real-time control software

    NASA Technical Reports Server (NTRS)

    Johnson, Jim; Biglari, Haik; Lehman, Larry

    1990-01-01

    The need to increase engineering productivity and decrease software life cycle costs in real-time system development establishes a motivation for a method of rapid prototyping. The design by iterative rapid prototyping technique is described. A tool which facilitates such a design methodology for the generation of embedded control software is described.

  11. A Model and Simple Iterative Algorithm for Redundancy Analysis.

    ERIC Educational Resources Information Center

    Fornell, Claes; And Others

    1988-01-01

    This paper shows that redundancy maximization with J. K. Johansson's extension can be accomplished via a simple iterative algorithm based on H. Wold's Partial Least Squares. The model and the iterative algorithm for the least squares approach to redundancy maximization are presented. (TJH)

  12. Lessons Drawn from ITER and Other Fusion International Collaborations

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.

    1998-06-01

    The international character of fusion research and development is described, with special emphasis on the ITER (International Thermonuclear Experimental Reactor) joint venture. The history of the ITER collaboration is traced. Lessons drawn that may prove useful for future ventures are presented.

  13. An Iterative Method for Solving Variable Coefficient ODEs

    ERIC Educational Resources Information Center

    Deeba, Elias; Yoon, Jeong-Mi; Zafiris, Vasilis

    2003-01-01

    In this classroom note, the authors present a method to solve variable coefficients ordinary differential equations of the form p(x)y([squared])(x) + q(x)y([superscript 1])(x) + r(x)y(x) = 0. They propose an iterative method as an alternate method to solve the above equation. This iterative method is accessible to an undergraduate student studying…

  14. Not so Complex: Iteration in the Complex Plane

    ERIC Educational Resources Information Center

    O'Dell, Robin S.

    2014-01-01

    The simple process of iteration can produce complex and beautiful figures. In this article, Robin O'Dell presents a set of tasks requiring students to use the geometric interpretation of complex number multiplication to construct linear iteration rules. When the outputs are plotted in the complex plane, the graphs trace pleasing designs…

  15. Wall conditioning for ITER: Current experimental and modeling activities

    NASA Astrophysics Data System (ADS)

    Douai, D.; Kogut, D.; Wauters, T.; Brezinsek, S.; Hagelaar, G. J. M.; Hong, S. H.; Lomas, P. J.; Lyssoivan, A.; Nunes, I.; Pitts, R. A.; Rohde, V.; de Vries, P. C.

    2015-08-01

    Wall conditioning will be required in ITER to control fuel and impurity recycling, as well as tritium (T) inventory. Analysis of conditioning cycle on the JET, with its ITER-Like Wall is presented, evidencing reduced need for wall cleaning in ITER compared to JET-CFC. Using a novel 2D multi-fluid model, current density during Glow Discharge Conditioning (GDC) on the in-vessel plasma-facing components (PFC) of ITER is predicted to approach the simple expectation of total anode current divided by wall surface area. Baking of the divertor to 350 °C should desorb the majority of the co-deposited T. ITER foresees the use of low temperature plasma based techniques compatible with the permanent toroidal magnetic field, such as Ion (ICWC) or Electron Cyclotron Wall Conditioning (ECWC), for tritium removal between ITER plasma pulses. Extrapolation of JET ICWC results to ITER indicates removal comparable to estimated T-retention in nominal ITER D:T shots, whereas GDC may be unattractive for that purpose.

  16. Experimental investigation of iterative reconstruction techniques for high resolution mammography

    NASA Astrophysics Data System (ADS)

    Vengrinovich, Valery L.; Zolotarev, Sergei A.; Linev, Vladimir N.

    2014-02-01

    The further development of the new iterative reconstruction algorithms to improve three-dimensional breast images quality restored from incomplete and noisy mammograms, is provided. The algebraic reconstruction method with simultaneous iterations - Simultaneous Algebraic Reconstruction Technique (SART) and the iterative method of statistical reconstruction Bayesian Iterative Reconstruction (BIR) are referred here as the preferable iterative methods suitable to improve the image quality. For better processing we use the Graphics Processing Unit (GPU). Method of minimizing the Total Variation (TV) is used as a priori support for regularization of iteration process and to reduce the level of noise in the reconstructed image. Preliminary results with physical phantoms show that all examined methods are capable to reconstruct structures layer-by-layer and to separate layers which images are overlapped in the Z- direction. It was found that the method of traditional Shift-And-Add tomosynthesis (SAA) is worse than iterative methods SART and BIR in terms of suppression of the anatomical noise and image blurring in between the adjacent layers. Despite of the fact that the measured contrast/noise ratio in the presence of low contrast internal structures is higher for the method of tomosynthesis SAA than for SART and BIR methods, its effectiveness in the presence of structured background is rather poor. In our opinion the optimal results can be achieved using Bayesian iterative reconstruction BIR.

  17. Magnet design technical report---ITER definition phase

    SciTech Connect

    Henning, C.

    1989-04-28

    This report contains papers on the following topics: conceptual design; radiation damage of ITER magnet systems; insulation system of the magnets; critical current density and strain sensitivity; toroidal field coil structural analysis; stress analysis for the ITER central solenoid; and volt-second capabilities and PF magnet configurations.

  18. Energy confinement scaling and the extrapolation to ITER

    SciTech Connect

    1997-11-01

    The fusion performance of ITER is predicted using three different techniques; statistical analysis of the global energy confinement data, a dimensionless physics parameter similarity method and the full 1-D modeling of the plasma profiles. Although the three methods give overlapping predictions for the performance of ITER, the confidence interval of all of the techniques is still quite wide.

  19. Validation of 1-D transport and sawtooth models for ITER

    SciTech Connect

    Connor, J.W.; Turner, M.F.; Attenberger, S.E.; Houlberg, W.A.

    1996-12-31

    In this paper the authors describe progress on validating a number of local transport models by comparing their predictions with relevant experimental data from a range of tokamaks in the ITER profile database. This database, the testing procedure and results are discussed. In addition a model for sawtooth oscillations is used to investigate their effect in an ITER plasma with alpha-particles.

  20. The Effect of Iteration on the Design Performance of Primary School Children

    ERIC Educational Resources Information Center

    Looijenga, Annemarie; Klapwijk, Remke; de Vries, Marc J.

    2015-01-01

    Iteration during the design process is an essential element. Engineers optimize their design by iteration. Research on iteration in Primary Design Education is however scarce; possibly teachers believe they do not have enough time for iteration in daily classroom practices. Spontaneous playing behavior of children indicates that iteration fits in…

  1. Image Restoration Using the Damped Richardson-Lucy Iteration

    NASA Astrophysics Data System (ADS)

    White, R. L.

    The most widely used image restoration technique for optical astronomical data is the Richardson-Lucy (RL) iteration. The RL method is well-suited to optical and ultraviolet because it converges to the maximum likelihood solution for Poisson statistics in the data, which is appropriate for astronomical images taken with CCD or photon-counting detectors. Images restored using the RL iteration have good good photometric linearity and can be used for quantitative analysis, and typical RL restorations require a manageable amount of computer time. Despite its advantages, the RL method has some serious shortcomings. Noise amplification is a problem, as for all maximum likelihood techniques. If one performs many RL iterations on an image containing an extended object such as a galaxy, the extended emission develops a ``speckled'' appearance. The speckles are the result of fitting the noise in the data too closely. The only limit on the amount of noise amplification in the RL method is the requirement that the image not become negative. The usual practical approach to limiting noise amplification is simply to stop the iteration when the restored image appears to become too noisy. However, in most cases the number of iterations needed is different for different parts of the image. Hundreds of iterations may be required to get a good fit to the high signal-to-noise image of a bright star, while a smooth, extended object may be fitted well after only a few iterations. Thus, one would like to be able to slow or stop the iteration automatically in regions where a smooth model fits the data adequately, while continuing to iterate in regions where there are sharp features (edges or point sources). The need for a spatially adaptive convergence criterion is exacerbated when CCD readout noise is included in the RL algorithm (Snyder, Hammoud, & White, 1993, JOSA A , 10 , 1014), because the rate of convergence is then slower for faint stars than for bright stars. This paper will

  2. [Electromagnetic urological stimulator].

    PubMed

    Zaslavskiĭ AOi; Markarov, G S; Gelis, Iu S

    1997-01-01

    The paper deals with an electromagnetic urological stimulator which generates a modulated low-frequency electromagnetic field of nonthermal intensity and its brief technical data. It presents a treatment regimen for urolithiasis and recommendations how to use the above therapeutical agent to stimulate urinary function in patients with urolithiasis in order to inoperatively eliminate urinary calculi and sand which form following extracorporeal shockwave lithotripsy.

  3. Stimulating your appetite.

    PubMed

    Whitfield, L

    1998-01-01

    A number of legal and illegal drugs can help stimulate appetite and are used for people with HIV to prevent wasting. Stimulating hunger is important because lower calorie intake and poor absorption of nutrients are associated with wasting. The uses and potential drawbacks of marijuana, thalidomide (Synovir), Marinol, and Megace are described. PMID:11365223

  4. A lower hybrid current drive system for ITER

    NASA Astrophysics Data System (ADS)

    Hoang, G. T.; Bécoulet, A.; Jacquinot, J.; Artaud, J. F.; Bae, Y. S.; Beaumont, B.; Belo, J. H.; Berger-By, G.; Bizarro, João P. S.; Bonoli, P.; Cho, M. H.; Decker, J.; Delpech, L.; Ekedahl, A.; Garcia, J.; Giruzzi, G.; Goniche, M.; Gormezano, C.; Guilhem, D.; Hillairet, J.; Imbeaux, F.; Kazarian, F.; Kessel, C.; Kim, S. H.; Kwak, J. G.; Jeong, J. H.; Lister, J. B.; Litaudon, X.; Magne, R.; Milora, S.; Mirizzi, F.; Namkung, W.; Noterdaeme, J. M.; Park, S. I.; Parker, R.; Peysson, Y.; Rasmussen, D.; Sharma, P. K.; Schneider, M.; Synakowski, E.; Tanga, A.; Tuccillo, A.; Wan, Y. X.

    2009-07-01

    A 20 MW/5 GHz lower hybrid current drive (LHCD) system was initially due to be commissioned and used for the second mission of ITER, i.e. the Q = 5 steady state target. Though not part of the currently planned procurement phase, it is now under consideration for an earlier delivery. In this paper, both physics and technology conceptual designs are reviewed. Furthermore, an appropriate work plan is also developed. This work plan for design, R&D, procurement and installation of a 20 MW LHCD system on ITER follows the ITER Scientific and Technical Advisory Committee (STAC) T13-05 task instructions. It gives more details on the various scientific and technical implications of the system, without presuming on any work or procurement sharing amongst the possible ITER partnersb The LHCD system of ITER is not part of the initial cost sharing.. This document does not commit the Institutions or Domestic Agencies of the various authors in that respect.

  5. Preliminary consideration of CFETR ITER-like case diagnostic system

    NASA Astrophysics Data System (ADS)

    Li, G. S.; Yang, Y.; Wang, Y. M.; Ming, T. F.; Han, X.; Liu, S. C.; Wang, E. H.; Liu, Y. K.; Yang, W. J.; Li, G. Q.; Hu, Q. S.; Gao, X.

    2016-11-01

    Chinese Fusion Engineering Test Reactor (CFETR) is a new superconducting tokamak device being designed in China, which aims at bridging the gap between ITER and DEMO, where DEMO is a tokamak demonstration fusion reactor. Two diagnostic cases, ITER-like case and towards DEMO case, have been considered for CFETR early and later operating phases, respectively. In this paper, some preliminary consideration of ITER-like case will be presented. Based on ITER diagnostic system, three versions of increased complexity and coverage of the ITER-like case diagnostic system have been developed with different goals and functions. Version A aims only machine protection and basic control. Both of version B and version C are mainly for machine protection, basic and advanced control, but version C has an increased level of redundancy necessary for improved measurements capability. The performance of these versions and needed R&D work are outlined.

  6. Final Report on ITER Task Agreement 81-10

    SciTech Connect

    Brad J. Merrill

    2009-01-01

    An International Thermonuclear Experimental Reactor (ITER) Implementing Task Agreement (ITA) on Magnet Safety was established between the ITER International Organization (IO) and the Idaho National Laboratory (INL) Fusion Safety Program (FSP) during calendar year 2004. The objectives of this ITA were to add new capabilities to the MAGARC code and to use this updated version of MAGARC to analyze unmitigated superconductor quench events for both poloidal field (PF) and toroidal field (TF) coils of the ITER design. This report documents the completion of the work scope for this ITA. Based on the results obtained for this ITA, an unmitigated quench event in an ITER larger PF coil does not appear to be as severe an accident as in an ITER TF coil.

  7. Comparison of starting values for iterative solutions to a universal Kepler's equation

    NASA Technical Reports Server (NTRS)

    Bergam, M. J.; Prussing, J. E.

    1982-01-01

    General starting values for the iterative numerical solution of a universal Kepler's equation for position in a conic orbit at a specified time are investigated. Three starting values based on recent refinements of previously obtained bounds on the solution are derived and tested numerically. Of these, a simple starting value based on a cubic approximation to Kepler's equation provides the most rapid convergence using both first and second order Newton algorithms. The performance of the starting values are compared with similar studies which used the restricted case of elliptical orbits with the initial epoch at periapse.

  8. Iterative reconstruction methods in atmospheric tomography: FEWHA, Kaczmarz and Gradient-based algorithm

    NASA Astrophysics Data System (ADS)

    Ramlau, R.; Saxenhuber, D.; Yudytskiy, M.

    2014-07-01

    The problem of atmospheric tomography arises in ground-based telescope imaging with adaptive optics (AO), where one aims to compensate in real-time for the rapidly changing optical distortions in the atmosphere. Many of these systems depend on a sufficient reconstruction of the turbulence profiles in order to obtain a good correction. Due to steadily growing telescope sizes, there is a strong increase in the computational load for atmospheric reconstruction with current methods, first and foremost the MVM. In this paper we present and compare three novel iterative reconstruction methods. The first iterative approach is the Finite Element- Wavelet Hybrid Algorithm (FEWHA), which combines wavelet-based techniques and conjugate gradient schemes to efficiently and accurately tackle the problem of atmospheric reconstruction. The method is extremely fast, highly flexible and yields superior quality. Another novel iterative reconstruction algorithm is the three step approach which decouples the problem in the reconstruction of the incoming wavefronts, the reconstruction of the turbulent layers (atmospheric tomography) and the computation of the best mirror correction (fitting step). For the atmospheric tomography problem within the three step approach, the Kaczmarz algorithm and the Gradient-based method have been developed. We present a detailed comparison of our reconstructors both in terms of quality and speed performance in the context of a Multi-Object Adaptive Optics (MOAO) system for the E-ELT setting on OCTOPUS, the ESO end-to-end simulation tool.

  9. Mapping raised bogs with an iterative one-class classification approach

    NASA Astrophysics Data System (ADS)

    Mack, Benjamin; Roscher, Ribana; Stenzel, Stefanie; Feilhauer, Hannes; Schmidtlein, Sebastian; Waske, Björn

    2016-10-01

    Land use and land cover maps are one of the most commonly used remote sensing products. In many applications the user only requires a map of one particular class of interest, e.g. a specific vegetation type or an invasive species. One-class classifiers are appealing alternatives to common supervised classifiers because they can be trained with labeled training data of the class of interest only. However, training an accurate one-class classification (OCC) model is challenging, particularly when facing a large image, a small class and few training samples. To tackle these problems we propose an iterative OCC approach. The presented approach uses a biased Support Vector Machine as core classifier. In an iterative pre-classification step a large part of the pixels not belonging to the class of interest is classified. The remaining data is classified by a final classifier with a novel model and threshold selection approach. The specific objective of our study is the classification of raised bogs in a study site in southeast Germany, using multi-seasonal RapidEye data and a small number of training sample. Results demonstrate that the iterative OCC outperforms other state of the art one-class classifiers and approaches for model selection. The study highlights the potential of the proposed approach for an efficient and improved mapping of small classes such as raised bogs. Overall the proposed approach constitutes a feasible approach and useful modification of a regular one-class classifier.

  10. Evaluating iterative reconstruction performance in computed tomography

    SciTech Connect

    Chen, Baiyu Solomon, Justin; Ramirez Giraldo, Juan Carlos; Samei, Ehsan

    2014-12-15

    Purpose: Iterative reconstruction (IR) offers notable advantages in computed tomography (CT). However, its performance characterization is complicated by its potentially nonlinear behavior, impacting performance in terms of specific tasks. This study aimed to evaluate the performance of IR with both task-specific and task-generic strategies. Methods: The performance of IR in CT was mathematically assessed with an observer model that predicted the detection accuracy in terms of the detectability index (d′). d′ was calculated based on the properties of the image noise and resolution, the observer, and the detection task. The characterizations of image noise and resolution were extended to accommodate the nonlinearity of IR. A library of tasks was mathematically modeled at a range of sizes (radius 1–4 mm), contrast levels (10–100 HU), and edge profiles (sharp and soft). Unique d′ values were calculated for each task with respect to five radiation exposure levels (volume CT dose index, CTDI{sub vol}: 3.4–64.8 mGy) and four reconstruction algorithms (filtered backprojection reconstruction, FBP; iterative reconstruction in imaging space, IRIS; and sinogram affirmed iterative reconstruction with strengths of 3 and 5, SAFIRE3 and SAFIRE5; all provided by Siemens Healthcare, Forchheim, Germany). The d′ values were translated into the areas under the receiver operating characteristic curve (AUC) to represent human observer performance. For each task and reconstruction algorithm, a threshold dose was derived as the minimum dose required to achieve a threshold AUC of 0.9. A task-specific dose reduction potential of IR was calculated as the difference between the threshold doses for IR and FBP. A task-generic comparison was further made between IR and FBP in terms of the percent of all tasks yielding an AUC higher than the threshold. Results: IR required less dose than FBP to achieve the threshold AUC. In general, SAFIRE5 showed the most significant dose reduction

  11. Rapid and Iterative Estimation of Predictions of High School Graduation and Other Milestones

    ERIC Educational Resources Information Center

    Porter, Kristin E.; Balu, Rekha; Gunton, Brad; Pestronk, Jefferson; Cohen, Allison

    2016-01-01

    With the advent of data systems that allow for frequent or even real-time student data updates, and recognition that high school students often can move from being on-track to graduation to off-track in a matter of weeks, indicator analysis alone may not provide a complete picture to guide school leaders' actions. The authors of this paper suggest…

  12. FRANCHFRI: the Finite-RANge Constrained Hartree-Fock Rapid Iterator

    SciTech Connect

    Younes, W; Gogny, D

    2007-01-22

    The Hartree-Fock code FRANCHFRI, which uses a finite-range nucleon-nucleon interaction, has been written and benchmarked. This code represents a new LLNL capability for realistic calculations in both nuclear-structure and nuclear-reaction physics. The use of a finite-range interaction represents a considerable improvement over other Hartree-Fock codes currently available in the public domain, which rely on zero-range forces. The finite-range force does not simply lead to a more realistic treatment of the nuclear problem, it avoids serious mathematical pathologies inherent to zero-range interactions. This brief and non-technical report introduces the code, its design philosophy, various benchmarks used to test its accuracy, and places it within its proper physics context. The current limitations and planned extensions of the code are also discussed.

  13. Electron cyclotron emission diagnostic for ITER

    SciTech Connect

    Rowan, W.; Austin, M.; Phillips, P.; Beno, J.; Ouroua, A.; Ellis, R.; Feder, R.; Patel, A.

    2010-10-15

    Electron temperature measurements and electron thermal transport inferences will be critical to the nonactive and deuterium phases of ITER operation and will take on added importance during the alpha heating phase. The diagnostic must meet stringent criteria on spatial coverage and spatial resolution during full field operation. During the early phases of operation, it must operate equally well at half field. The key to the diagnostic is the front end design. It consists of a quasioptical antenna and a pair of calibration sources. The radial resolution of the diagnostic is less than 0.06 m. The spatial coverage extends at least from the core to the separatrix with first harmonic O-mode being used for the core and second harmonic X-mode being used for the pedestal. The instrumentation used for the core measurement at full field can be used for detection at half field by changing the detected polarization. Intermediate fields are accessible. The electron cyclotron emission systems require in situ calibration, which is provided by a novel hot calibration source. The critical component for the hot calibration source, the emissive surface, has been successfully tested. A prototype hot calibration source has been designed, making use of extensive thermal and mechanical modeling.

  14. Electron cyclotron emission diagnostic for ITER.

    PubMed

    Rowan, W; Austin, M; Beno, J; Ellis, R; Feder, R; Ouroua, A; Patel, A; Phillips, P

    2010-10-01

    Electron temperature measurements and electron thermal transport inferences will be critical to the nonactive and deuterium phases of ITER operation and will take on added importance during the alpha heating phase. The diagnostic must meet stringent criteria on spatial coverage and spatial resolution during full field operation. During the early phases of operation, it must operate equally well at half field. The key to the diagnostic is the front end design. It consists of a quasioptical antenna and a pair of calibration sources. The radial resolution of the diagnostic is less than 0.06 m. The spatial coverage extends at least from the core to the separatrix with first harmonic O-mode being used for the core and second harmonic X-mode being used for the pedestal. The instrumentation used for the core measurement at full field can be used for detection at half field by changing the detected polarization. Intermediate fields are accessible. The electron cyclotron emission systems require in situ calibration, which is provided by a novel hot calibration source. The critical component for the hot calibration source, the emissive surface, has been successfully tested. A prototype hot calibration source has been designed, making use of extensive thermal and mechanical modeling.

  15. Iterated conformal dynamics and Laplacian growth.

    PubMed

    Barra, Felipe; Davidovitch, Benny; Procaccia, Itamar

    2002-04-01

    The method of iterated conformal maps for the study of diffusion limited aggregates (DLA) is generalized to the study of Laplacian growth patterns and related processes. We emphasize the fundamental difference between these processes: DLA is grown serially with constant size particles, while Laplacian patterns are grown by advancing each boundary point in parallel, proportional to the gradient of the Laplacian field. We introduce a two-parameter family of growth patterns that interpolates between DLA and a discrete version of Laplacian growth. The ultraviolet putative finite-time singularities are regularized here by a minimal tip size, equivalently for all the models in this family. With this we stress that the difference between DLA and Laplacian growth is not in the manner of ultraviolet regularization, but rather in their deeply different growth rules. The fractal dimensions of the asymptotic patterns depend continuously on the two parameters of the family, giving rise to a "phase diagram" in which DLA and discretized Laplacian growth are at the extreme ends. In particular, we show that the fractal dimension of Laplacian growth patterns is higher than the fractal dimension of DLA, with the possibility of dimension 2 for the former not excluded. PMID:12005963

  16. Sequence analysis by iterated maps, a review.

    PubMed

    Almeida, Jonas S

    2014-05-01

    Among alignment-free methods, Iterated Maps (IMs) are on a particular extreme: they are also scale free (order free). The use of IMs for sequence analysis is also distinct from other alignment-free methodologies in being rooted in statistical mechanics instead of computational linguistics. Both of these roots go back over two decades to the use of fractal geometry in the characterization of phase-space representations. The time series analysis origin of the field is betrayed by the title of the manuscript that started this alignment-free subdomain in 1990, 'Chaos Game Representation'. The clash between the analysis of sequences as continuous series and the better established use of Markovian approaches to discrete series was almost immediate, with a defining critique published in same journal 2 years later. The rest of that decade would go by before the scale-free nature of the IM space was uncovered. The ensuing decade saw this scalability generalized for non-genomic alphabets as well as an interest in its use for graphic representation of biological sequences. Finally, in the past couple of years, in step with the emergence of BigData and MapReduce as a new computational paradigm, there is a surprising third act in the IM story. Multiple reports have described gains in computational efficiency of multiple orders of magnitude over more conventional sequence analysis methodologies. The stage appears to be now set for a recasting of IMs with a central role in processing nextgen sequencing results.

  17. Selective Iterative Waterfilling for Digital Subscriber Lines

    NASA Astrophysics Data System (ADS)

    Xu, Yang; Le-Ngoc, Tho; Panigrahi, Saswat

    2007-12-01

    This paper presents a high-performance, low-complexity, quasi-distributed dynamic spectrum management (DSM) algorithm suitable for DSL systems. We analytically demonstrate that the rate degradation of the distributed iterative waterfilling (IW) algorithm in near-far scenarios is caused by the insufficient utilization of all available frequency and power resources due to its nature of noncooperative game theoretic formulation. Inspired by this observation, we propose the selective IW (SIW) algorithm that can considerably alleviate the performance degradation of IW by applying IW selectively to different groups of users over different frequency bands so that all the available resources can be fully utilized. For [InlineEquation not available: see fulltext.] users, the proposed SIW algorithm needs at most [InlineEquation not available: see fulltext.] times the complexity of the IW algorithm, and is much simpler than the centralized optimal spectrum balancing (OSB), while it can offer a rate performance much better than that of the IW and close to the maximum possible rate region computed by the OSB in realistic near-far DSL scenarios. Furthermore, its predominantly distributed structure makes it suitable for DSL implementation.

  18. SPECIAL TOPIC: ITER L mode confinement database

    NASA Astrophysics Data System (ADS)

    Kaye, S. M.; Greenwald, M.; Stroth, U.; Kardaun, O.; Kus, A.; Schissel, D.; DeBoo, J.; Bracco, G.; Thomsen, K.; Cordey, J. G.; Miura, Y.; Matsuda, T.; Tamai, H.; Takizuda, T.; Hirayama, T.; Kikuchi, H.; Naito, O.; Chudnovskij, A.; Ongena, J.; Hoang, G.

    1997-09-01

    This special topic describes the contents of an L mode database that has been compiled with data from Alcator C-Mod, ASDEX, DIII, DIII-D, FTU, JET, JFT-2M, JT-60, PBX-M, PDX, T-10, TEXTOR, TFTR and Tore Supra. The database consists of a total of 2938 entries, 1881 of which are in the L phase while 922 are ohmically heated only (ohmic). Each entry contains up to 95 descriptive parameters, including global and kinetic information, machine conditioning and configuration. The special topic presents a description of the database and the variables contained therein, and it also presents global and thermal scalings along with predictions for ITER. The L mode thermal confinement time scaling, determined from a subset of 1312 entries for which the τE,th are provided, is τE,th = 0.023Ip0.96BT0.03R1.83(R/a)0.06 κ0.64ne0.40Meff0.20P-0.73 in units of seconds, megamps, teslas, metres, -, -, 10-9 m-1

  19. Sequence analysis by iterated maps, a review.

    PubMed

    Almeida, Jonas S

    2014-05-01

    Among alignment-free methods, Iterated Maps (IMs) are on a particular extreme: they are also scale free (order free). The use of IMs for sequence analysis is also distinct from other alignment-free methodologies in being rooted in statistical mechanics instead of computational linguistics. Both of these roots go back over two decades to the use of fractal geometry in the characterization of phase-space representations. The time series analysis origin of the field is betrayed by the title of the manuscript that started this alignment-free subdomain in 1990, 'Chaos Game Representation'. The clash between the analysis of sequences as continuous series and the better established use of Markovian approaches to discrete series was almost immediate, with a defining critique published in same journal 2 years later. The rest of that decade would go by before the scale-free nature of the IM space was uncovered. The ensuing decade saw this scalability generalized for non-genomic alphabets as well as an interest in its use for graphic representation of biological sequences. Finally, in the past couple of years, in step with the emergence of BigData and MapReduce as a new computational paradigm, there is a surprising third act in the IM story. Multiple reports have described gains in computational efficiency of multiple orders of magnitude over more conventional sequence analysis methodologies. The stage appears to be now set for a recasting of IMs with a central role in processing nextgen sequencing results. PMID:24162172

  20. Mixed Confidence Estimation for Iterative CT Reconstruction.

    PubMed

    Perlmutter, David S; Kim, Soo Mee; Kinahan, Paul E; Alessio, Adam M

    2016-09-01

    Dynamic (4D) CT imaging is used in a variety of applications, but the two major drawbacks of the technique are its increased radiation dose and longer reconstruction time. Here we present a statistical analysis of our previously proposed Mixed Confidence Estimation (MCE) method that addresses both these issues. This method, where framed iterative reconstruction is only performed on the dynamic regions of each frame while static regions are fixed across frames to a composite image, was proposed to reduce computation time. In this work, we generalize the previous method to describe any application where a portion of the image is known with higher confidence (static, composite, lower-frequency content, etc.) and a portion of the image is known with lower confidence (dynamic, targeted, etc). We show that by splitting the image space into higher and lower confidence components, MCE can lower the estimator variance in both regions compared to conventional reconstruction. We present a theoretical argument for this reduction in estimator variance and verify this argument with proof-of-principle simulations. We also propose a fast approximation of the variance of images reconstructed with MCE and confirm that this approximation is accurate compared to analytic calculations of and multi-realization image variance. This MCE method requires less computation time and provides reduced image variance for imaging scenarios where portions of the image are known with more certainty than others allowing for potentially reduced radiation dose and/or improved dynamic imaging. PMID:27008663

  1. On different results for new three step iteration process in Banach spaces.

    PubMed

    Ullah, Kifayat; Arshad, Muhammad

    2016-01-01

    In this paper we propose a new iteration process, called AK iteration process, for approximation of fixed points for contraction mappings. We show that our iteration process is faster than the leading Vatan Two-step iteration process for contraction mappings. Numerical examples are given to support the analytic proofs. Stability of AK iteration process and data dependence result for contraction mappings by employing AK iteration process are also discussed. PMID:27652189

  2. On different results for new three step iteration process in Banach spaces.

    PubMed

    Ullah, Kifayat; Arshad, Muhammad

    2016-01-01

    In this paper we propose a new iteration process, called AK iteration process, for approximation of fixed points for contraction mappings. We show that our iteration process is faster than the leading Vatan Two-step iteration process for contraction mappings. Numerical examples are given to support the analytic proofs. Stability of AK iteration process and data dependence result for contraction mappings by employing AK iteration process are also discussed.

  3. Fourier mode analysis of source iteration in spatially periodic media

    SciTech Connect

    Zika, M.R.; Larsen, E.W.

    1998-12-31

    The standard Fourier mode analysis is an indispensable tool when designing acceleration techniques for transport iterations; however, it requires the assumption of a homogeneous infinite medium. For problems of practical interest, material heterogeneities may significantly impact iterative performance. Recent work has applied a Fourier analysis to the discretized two-dimensional transport operator with heterogeneous material properties. The results of these analyses may be difficult to interpret because the heterogeneity effects are inherently coupled to the discretization effects. Here, the authors describe a Fourier analysis of source iteration (SI) that allows the calculation of the eigenvalue spectrum for the one-dimensional continuous transport operator with spatially periodic heterogeneous media.

  4. SUMMARY REPORT-FY2006 ITER WORK ACCOMPLISHED

    SciTech Connect

    Martovetsky, N N

    2006-04-11

    Six parties (EU, Japan, Russia, US, Korea, China) will build ITER. The US proposed to deliver at least 4 out of 7 modules of the Central Solenoid. Phillip Michael (MIT) and I were tasked by DoE to assist ITER in development of the ITER CS and other magnet systems. We work to help Magnets and Structure division headed by Neil Mitchell. During this visit I worked on the selected items of the CS design and carried out other small tasks, like PF temperature margin assessment.

  5. Perturbation-iteration theory for analyzing microwave striplines

    NASA Technical Reports Server (NTRS)

    Kretch, B. E.

    1985-01-01

    A perturbation-iteration technique is presented for determining the propagation constant and characteristic impedance of an unshielded microstrip transmission line. The method converges to the correct solution with a few iterations at each frequency and is equivalent to a full wave analysis. The perturbation-iteration method gives a direct solution for the propagation constant without having to find the roots of a transcendental dispersion equation. The theory is presented in detail along with numerical results for the effective dielectric constant and characteristic impedance for a wide range of substrate dielectric constants, stripline dimensions, and frequencies.

  6. Qualification tests and facilities for the ITER superconductors

    NASA Astrophysics Data System (ADS)

    Bruzzone, P.; Wesche, R.; Stepanov, B.; Cau, F.; Bagnasco, M.; Calvi, M.; Herzog, R.; Vogel, M.

    2009-06-01

    All the ITER superconductors are tested as short length samples in the SULTAN test facility at CRPP. Twenty-four TF conductor samples with small layout variations were tested since February 2007 with the aim of verifying the design and qualification of the manufacturers. The sample assembly and the measurement techniques at CRPP are discussed. Starting in 2010, another test facility for ITER conductors, named EDIPO, will be operating at CRPP to share with SULTAN the load of the samples for the acceptance tests during the construction of ITER.

  7. Iterative method for elliptic problems on regions partitioned into substructures

    SciTech Connect

    Bramble, J.H.; Pasciak, J.E.; Schatz, A.H.

    1986-04-01

    Some new preconditioners for discretizations of elliptic boundary problems are studied. With these preconditioners, the domain under consideration is broken into subdomains and preconditioners are defined which only require the solution of matrix problems on the subdomains. Analytic estimates are given which guarantee that under appropriate hypotheses, the preconditioned iterative procedure converges to the solution of the discrete equations with a rate per iteration that is independent of the number of unknowns. Numerical examples are presented which illustrate the theoretically predicted iterative convergence rates.

  8. Iterative schemes for nonsymmetric and indefinite elliptic boundary value problems

    SciTech Connect

    Bramble, J.H.; Leyk, Z.; Pasciak, J.E.

    1993-01-01

    The purpose of this paper is twofold. The first is to describe some simple and robust iterative schemes for nonsymmetric and indefinite elliptic boundary value problems. The schemes are based in the Sobolev space H ([Omega]) and require minimal hypotheses. The second is to develop algorithms utilizing a coarse-grid approximation. This leads to iteration matrices whose eigenvalues lie in the right half of the complex plane. In fact, for symmetric indefinite problems, the iteration is reduced to a well-conditioned symmetric positive definite system which can be solved by conjugate gradient interation. Applications of the general theory as well as numerical examples are given. 20 refs., 8 tabs.

  9. Shattered Pellet Disruption Mitigation Technology Development for ITER

    SciTech Connect

    Baylor, Larry R; Combs, Stephen Kirk; Jernigan, T. C.; Meitner, Steven J; Edgemon, Timothy D; Parks, P. B.; Commaux, Nicolas JC; Maruyama, S.; Caughman, John B; Rasmussen, David A

    2010-01-01

    The mitigation of first wall thermal and mechanical loads and damage from runaway electrons during disruptions are critical for successful long term operation of ITER. Disruption mitigation tools based on shattered pellet injection are being developed at Oak Ridge National Laboratory that can be employed on ITER to provide the necessary mitigation of thermal and mechanical loads from disruptions as well as provide collisional damping to inhibit the formation of runaway electrons . Here we present progress on the development of the technology to provide reliable disruption mitigation with large shattered cryogenic pellets. An example of how this concept can be employed on ITER is discussed.

  10. Disruptions in ITER and strategies for their control and mitigation

    NASA Astrophysics Data System (ADS)

    Lehnen, M.; Aleynikova, K.; Aleynikov, P. B.; Campbell, D. J.; Drewelow, P.; Eidietis, N. W.; Gasparyan, Yu.; Granetz, R. S.; Gribov, Y.; Hartmann, N.; Hollmann, E. M.; Izzo, V. A.; Jachmich, S.; Kim, S.-H.; Kočan, M.; Koslowski, H. R.; Kovalenko, D.; Kruezi, U.; Loarte, A.; Maruyama, S.; Matthews, G. F.; Parks, P. B.; Pautasso, G.; Pitts, R. A.; Reux, C.; Riccardo, V.; Roccella, R.; Snipes, J. A.; Thornton, A. J.; de Vries, P. C.

    2015-08-01

    The thermal and electromagnetic loads related to disruptions in ITER are substantial and require careful design of tokamak components to ensure they reach the projected lifetime and to ensure that safety relevant components fulfil their function for the worst foreseen scenarios. The disruption load specifications are the basis for the design process of components like the full-W divertor, the blanket modules and the vacuum vessel and will set the boundary conditions for ITER operations. This paper will give a brief overview on the disruption loads and mitigation strategies for ITER and will discuss the physics basis which is continuously refined through the current disruption R&D programs.

  11. Conference on iterative methods for large linear systems

    SciTech Connect

    Kincaid, D.R.

    1988-12-01

    This conference is dedicated to providing an overview of the state of the art in the use of iterative methods for solving sparse linear systems with an eye to contributions of the past, present and future. The emphasis is on identifying current and future research directions in the mainstream of modern scientific computing. Recently, the use of iterative methods for solving linear systems has experienced a resurgence of activity as scientists attach extremely complicated three-dimensional problems using vector and parallel supercomputers. Many research advances in the development of iterative methods for high-speed computers over the past forty years are reviewed, as well as focusing on current research.

  12. Optically stimulated luminescence dosimetry

    NASA Astrophysics Data System (ADS)

    McKeever, Stephen W. S.

    2001-09-01

    Models and the conceptual framework necessary for an understanding of optically stimulated luminescence (OSL) are described. Examples of various OSL readout schemes are described, along with examples of the use of OSL in radiation dosimetry.

  13. Deep brain stimulation

    MedlinePlus

    ... the brain The neurostimulator, which puts out the electric current. The stimulator is similar to a heart pacemaker . It is usually placed under the skin near the collarbone, but may be ... pulses travel from the neurostimulator, along the extension ...

  14. ACTH stimulation test

    MedlinePlus

    ... Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric . 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 102. Chernecky CC, Berger BJ. ACTH stimulation test - diagnostic. In: ... . 13th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap ...

  15. Geothermal Well Stimulation

    SciTech Connect

    Campbell, D. A.; Morris, C. W.; Sinclair, A. R.; Hanold, R. J.; Vetter, O. J.

    1981-03-01

    The stimulation of geothermal wells presents some new and challenging problems. Formation temperatures in the 300-600 F range can be expected. The behavior of stimulation fluids, frac proppants, and equipment at these temperatures in a hostile brine environment must be carefully evaluated before performance expectations can be determined. In order to avoid possible damage to the producing horizon of the formation, high temperature chemical compatibility between the in situ materials and the stimulation materials must be verified. Perhaps most significant of all, in geothermal wells the required techniques must be capable of bringing about the production of very large amounts of fluid. This necessity for high flow rates represents a significant departure from conventional petroleum well stimulation and demands the creation of very high near-wellbore permeability and/or fractures with very high flow conductivity.

  16. Braille line using electrical stimulation

    NASA Astrophysics Data System (ADS)

    Puertas, A.; Purés, P.; Echenique, A. M.; Ensinck, J. P. Graffigna y. G.

    2007-11-01

    Conceived within the field of Rehabilitation Technologies for visually impaired persons, the present work aims at enabling the blind user to read written material by means of a tactile display. Once he is familiarized to operate this system, the user will be able to achieve greater performance in study, academic and job activities, thus achieving a rapid and easier social inclusion. The devise accepts any kind of text that is computer-loadable (documents, books, Internet information, and the like) which, through digital means, can be read as Braille text on the pad. This tactile display is composed of an electrodes platform that simulate, through stimulation the writing/reading Braille characters. In order to perceive said characters in similar way to the tactile feeling from paper material, the skin receptor of fingers are stimulated electrically so as to simulate the same pressure and depressions as those of the paper-based counterpart information. Once designed and developed, the display was tested with blind subjects, with relatively satisfactory results. As a continuing project, this prototype is currently being improved as regards.

  17. Newton`s iteration for inversion of Cauchy-like and other structured matrices

    SciTech Connect

    Pan, V.Y.; Zheng, Ailong; Huang, Xiaohan; Dias, O.

    1996-12-31

    We specify some initial assumptions that guarantee rapid refinement of a rough initial approximation to the inverse of a Cauchy-like matrix, by mean of our new modification of Newton`s iteration, where the input, output, and all the auxiliary matrices are represented with their short generators defined by the associated scaling operators. The computations are performed fast since they are confined to operations with short generators of the given and computed matrices. Because of the known correlations among various structured matrices, the algorithm is immediately extended to rapid refinement of rough initial approximations to the inverses of Vandermonde-like, Chebyshev-Vandermonde-like and Toeplitz-like matrices, where again, the computations are confined to operations with short generators of the involved matrices.

  18. Electrostatic Dust Detection and Removal for ITER

    SciTech Connect

    C.H. Skinner; A. Campos; H. Kugel; J. Leisure; A.L. Roquemore; S. Wagner

    2008-09-01

    We present some recent results on two innovative applications of microelectronics technology to dust inventory measurement and dust removal in ITER. A novel device to detect the settling of dust particles on a remote surface has been developed in the laboratory. A circuit board with a grid of two interlocking conductive traces with 25 μm spacing is biased to 30 – 50 V. Carbon particles landing on the energized grid create a transient short circuit. The current flowing through the short circuit creates a voltage pulse that is recorded by standard nuclear counting electronics and the total number of counts is related to the mass of dust impinging on the grid. The particles typically vaporize in a few seconds restoring the previous voltage standoff. Experience on NSTX however, showed that in a tokamak environment it was still possible for large particles or fibers to remain on the grid causing a long term short circuit. We report on the development of a gas puff system that uses helium to clear such particles. Experiments with varying nozzle designs, backing pressures, puff durations, and exit flow orientations have given an optimal configuration that effectively removes particles from an area up to 25 cm² with a single nozzle. In a separate experiment we are developing an advanced circuit grid of three interlocking traces that can generate a miniature electrostatic traveling wave for transporting dust to a suitable exit port. We have fabricated such a 3-pole circuit board with 25 micron insulated traces that operates with voltages up to 200 V. Recent results showed motion of dust particles with the application of only 50 V bias voltage. Such a device could potentially remove dust continuously without dedicated interventions and without loss of machine availability for plasma operations.

  19. Sequence analysis by iterated maps, a review

    PubMed Central

    2014-01-01

    Among alignment-free methods, Iterated Maps (IMs) are on a particular extreme: they are also scale free (order free). The use of IMs for sequence analysis is also distinct from other alignment-free methodologies in being rooted in statistical mechanics instead of computational linguistics. Both of these roots go back over two decades to the use of fractal geometry in the characterization of phase-space representations. The time series analysis origin of the field is betrayed by the title of the manuscript that started this alignment-free subdomain in 1990, ‘Chaos Game Representation’. The clash between the analysis of sequences as continuous series and the better established use of Markovian approaches to discrete series was almost immediate, with a defining critique published in same journal 2 years later. The rest of that decade would go by before the scale-free nature of the IM space was uncovered. The ensuing decade saw this scalability generalized for non-genomic alphabets as well as an interest in its use for graphic representation of biological sequences. Finally, in the past couple of years, in step with the emergence of BigData and MapReduce as a new computational paradigm, there is a surprising third act in the IM story. Multiple reports have described gains in computational efficiency of multiple orders of magnitude over more conventional sequence analysis methodologies. The stage appears to be now set for a recasting of IMs with a central role in processing nextgen sequencing results. PMID:24162172

  20. Computational electromagnetic methods for transcranial magnetic stimulation

    NASA Astrophysics Data System (ADS)

    Gomez, Luis J.

    Transcranial magnetic stimulation (TMS) is a noninvasive technique used both as a research tool for cognitive neuroscience and as a FDA approved treatment for depression. During TMS, coils positioned near the scalp generate electric fields and activate targeted brain regions. In this thesis, several computational electromagnetics methods that improve the analysis, design, and uncertainty quantification of TMS systems were developed. Analysis: A new fast direct technique for solving the large and sparse linear system of equations (LSEs) arising from the finite difference (FD) discretization of Maxwell's quasi-static equations was developed. Following a factorization step, the solver permits computation of TMS fields inside realistic brain models in seconds, allowing for patient-specific real-time usage during TMS. The solver is an alternative to iterative methods for solving FD LSEs, often requiring run-times of minutes. A new integral equation (IE) method for analyzing TMS fields was developed. The human head is highly-heterogeneous and characterized by high-relative permittivities (107). IE techniques for analyzing electromagnetic interactions with such media suffer from high-contrast and low-frequency breakdowns. The novel high-permittivity and low-frequency stable internally combined volume-surface IE method developed. The method not only applies to the analysis of high-permittivity objects, but it is also the first IE tool that is stable when analyzing highly-inhomogeneous negative permittivity plasmas. Design: TMS applications call for electric fields to be sharply focused on regions that lie deep inside the brain. Unfortunately, fields generated by present-day Figure-8 coils stimulate relatively large regions near the brain surface. An optimization method for designing single feed TMS coil-arrays capable of producing more localized and deeper stimulation was developed. Results show that the coil-arrays stimulate 2.4 cm into the head while stimulating 3

  1. An iterative method for indefinite systems of linear equations

    NASA Technical Reports Server (NTRS)

    Ito, K.

    1984-01-01

    An iterative method for solving nonsymmetric indefinite linear systems is proposed. The method involves the successive use of a modified version of the conjugate residual method. A numerical example is given to illustrate the method.

  2. Multi-Level iterative methods in computational plasma physics

    SciTech Connect

    Knoll, D.A.; Barnes, D.C.; Brackbill, J.U.; Chacon, L.; Lapenta, G.

    1999-03-01

    Plasma physics phenomena occur on a wide range of spatial scales and on a wide range of time scales. When attempting to model plasma physics problems numerically the authors are inevitably faced with the need for both fine spatial resolution (fine grids) and implicit time integration methods. Fine grids can tax the efficiency of iterative methods and large time steps can challenge the robustness of iterative methods. To meet these challenges they are developing a hybrid approach where multigrid methods are used as preconditioners to Krylov subspace based iterative methods such as conjugate gradients or GMRES. For nonlinear problems they apply multigrid preconditioning to a matrix-few Newton-GMRES method. Results are presented for application of these multilevel iterative methods to the field solves in implicit moment method PIC, multidimensional nonlinear Fokker-Planck problems, and their initial efforts in particle MHD.

  3. Design standard issues for ITER in-vessel components

    SciTech Connect

    Majumdar, S.

    1994-06-01

    Unique requirements that must be addressed by a structural design code for the ITER have been summarized. Existing codes such as ASME Section III, or the French RCC-MR were developed primarily for fission reactor out-of-core components and are not directly applicable to the ITER. They may be used either as a guide for developing a design code for the ITER or as interim standards. However, new rules will be needed for handling the irradiation-induced embrittlement problems faced by the ITER blanket components. Design standards developed in the past for the design of fission reactor core components in the United States can be used as guides in this area.

  4. Leapfrog variants of iterative methods for linear algebra equations

    NASA Technical Reports Server (NTRS)

    Saylor, Paul E.

    1988-01-01

    Two iterative methods are considered, Richardson's method and a general second order method. For both methods, a variant of the method is derived for which only even numbered iterates are computed. The variant is called a leapfrog method. Comparisons between the conventional form of the methods and the leapfrog form are made under the assumption that the number of unknowns is large. In the case of Richardson's method, it is possible to express the final iterate in terms of only the initial approximation, a variant of the iteration called the grand-leap method. In the case of the grand-leap variant, a set of parameters is required. An algorithm is presented to compute these parameters that is related to algorithms to compute the weights and abscissas for Gaussian quadrature. General algorithms to implement the leapfrog and grand-leap methods are presented. Algorithms for the important special case of the Chebyshev method are also given.

  5. Iterative methods for elliptic finite element equations on general meshes

    NASA Technical Reports Server (NTRS)

    Nicolaides, R. A.; Choudhury, Shenaz

    1986-01-01

    Iterative methods for arbitrary mesh discretizations of elliptic partial differential equations are surveyed. The methods discussed are preconditioned conjugate gradients, algebraic multigrid, deflated conjugate gradients, an element-by-element techniques, and domain decomposition. Computational results are included.

  6. Final Report on ITER Task Agreement 81-18

    SciTech Connect

    Brad J. Merrill

    2008-02-01

    During 2007, the US International Thermonuclear Experimental Reactor (ITER) Project Office (USIPO) entered into a Task Agreement (TA) with the ITER International Organization (IO) to conduct Research and Development activity and/or Design activity in the area of Safety Analyses. There were four tasks within this TA, which were to provide the ITER IO with: 1) Quality Assurance (QA) documentation for the MELCOR 1.8.2 Fusion code, 2) a pedigreed version of MELCOR 1.8.2, 3) assistance in MELCOR input deck development and accident analyses, and 4) support and assistance in the operation of the MELCOR 1.8.2. This report, which is the final report for this agreement, documents the completion of the work scope under this ITER TA, designated as TA 81-18.

  7. International Thermonuclear Experimental Reactor (ITER) neutral beam design

    SciTech Connect

    Myers, T.J.; Brook, J.W.; Spampinato, P.T.; Mueller, J.P.; Luzzi, T.E.; Sedgley, D.W. . Space Systems Div.)

    1990-10-01

    This report discusses the following topics on ITER neutral beam design: ion dump; neutralizer and module gas flow analysis; vacuum system; cryogenic system; maintainability; power distribution; and system cost.

  8. Approximate inverse preconditioning of iterative methods for nonsymmetric linear systems

    SciTech Connect

    Benzi, M.; Tuma, M.

    1996-12-31

    A method for computing an incomplete factorization of the inverse of a nonsymmetric matrix A is presented. The resulting factorized sparse approximate inverse is used as a preconditioner in the iterative solution of Ax = b by Krylov subspace methods.

  9. Parallel iterative methods for sparse linear and nonlinear equations

    NASA Technical Reports Server (NTRS)

    Saad, Youcef

    1989-01-01

    As three-dimensional models are gaining importance, iterative methods will become almost mandatory. Among these, preconditioned Krylov subspace methods have been viewed as the most efficient and reliable, when solving linear as well as nonlinear systems of equations. There has been several different approaches taken to adapt iterative methods for supercomputers. Some of these approaches are discussed and the methods that deal more specifically with general unstructured sparse matrices, such as those arising from finite element methods, are emphasized.

  10. An automatic ordering method for incomplete factorization iterative solvers

    SciTech Connect

    Forsyth, P.A.; Tang, W.P. . Dept. of Computer Science); D'Azevedo, E.F.D. )

    1991-01-01

    The minimum discarded fill (MDF) ordering strategy for incomplete factorization iterative solvers is developed. MDF ordering is demonstrated for several model son-symmetric problems, as well as a water-flooding simulation which uses an unstructured grid. The model problems show a three to five fold decrease in the number of iterations compared to natural orderings. Greater than twofold improvement was observed for the waterflooding simulation. 26 refs., 7 figs., 3 tabs.

  11. Development of the ITER magnetic diagnostic set and specification.

    PubMed

    Vayakis, G; Arshad, S; Delhom, D; Encheva, A; Giacomin, T; Jones, L; Patel, K M; Pérez-Lasala, M; Portales, M; Prieto, D; Sartori, F; Simrock, S; Snipes, J A; Udintsev, V S; Watts, C; Winter, A; Zabeo, L

    2012-10-01

    ITER magnetic diagnostics are now in their detailed design and R&D phase. They have passed their conceptual design reviews and a working diagnostic specification has been prepared aimed at the ITER project requirements. This paper highlights specific design progress, in particular, for the in-vessel coils, steady state sensors, saddle loops and divertor sensors. Key changes in the measurement specifications, and a working concept of software and electronics are also outlined.

  12. An iterative method for systems of nonlinear hyperbolic equations

    NASA Technical Reports Server (NTRS)

    Scroggs, Jeffrey S.

    1989-01-01

    An iterative algorithm for the efficient solution of systems of nonlinear hyperbolic equations is presented. Parallelism is evident at several levels. In the formation of the iteration, the equations are decoupled, thereby providing large grain parallelism. Parallelism may also be exploited within the solves for each equation. Convergence of the interation is established via a bounding function argument. Experimental results in two-dimensions are presented.

  13. Visible and Infrared Optical Design for the ITER Upper Ports

    SciTech Connect

    Lasnier, C; Seppala, L; Morris, K; Groth, M; Fenstermacher, M; Allen, S; Synakowski, E; Ortiz, J

    2007-03-01

    This document contains the results of an optical design scoping study of visible-light and infrared optics for the ITER upper ports, performed by LLNL under contract for the US ITER Project Office. ITER is an international collaboration to build a large fusion energy tokamak with a goal of demonstrating net fusion power for pulses much longer than the energy confinement time. At the time of this report, six of the ITER upper ports are planned to each to contain a camera system for recording visible and infrared light, as well as other diagnostics. the performance specifications for the temporal and spatial resolution of this system are shown in the Section II, Functional Specifications. They acknowledge a debt to Y. Corre and co-authors of the CEA Cadarache report ''ITER wide-angle viewing and thermographic and visible system''. Several of the concepts used in this design are derived from that CEA report. The infrared spatial resolution for optics of this design is diffraction-limited by the size of the entrance aperture, at lower resolution than listed in the ITER diagnostic specifications. The size of the entrance aperture is a trade-off between spatial resolution, optics size in the port, and the location of relay optics. The signal-to-noise ratio allows operation at the specified time resolutions.

  14. Development of Jacketing Technologies for Iter CS and TF Conductor

    NASA Astrophysics Data System (ADS)

    Hamada, K.; Nakajima, H.; Matsui, K.; Kawano, K.; Takano, K.; Tsutsumi, F.; Okuno, K.; Teshima, O.; Soejima, K.

    2008-03-01

    The Japan Atomic Energy Agency (JAEA) has developed jacketing technologies for ITER Toroidal Field (TF) and Central Solenoid (CS) conductor. Full scale TF and CS conduits were fabricated using carbon-reduced SUS316LN and boron-added (˜40 ppm) high manganese stainless steel (0.025C -22Mn -13Cr -9Ni -0.12N: JK2LB), respectively. Welding condition was optimized so that back bead does not interfere a cable insertion. The weld joint samples were compacted by a compaction machine that was newly constructed and tested at 4.2 K. Mechanical characteristics at 4K of CS, TF conduits and CS welded joint satisfied ITER mechanical requirements. TF welded joint shows slightly lower value of 0.2% yield strength (885 MPa) than that of ITER requirement (900 MPa). The TF conduit contains nitrogen content of 0.14%, which is minimum value in ITER specification. The lower nitrogen content may be caused by the release of nitrogen from molten metal during non-filler welding resulting in a 4 K strength decrease. To satisfy the ITER requirements, minimum nitrogen contents of conduit should be increased from 0.14% to 0.15% at least. Therefore, JAEA successfully developed TF and CS conduits with welding technologies and finalized the procurement specification for ITER conductor jacketing.

  15. Potential molecular wires by an iterative divergent/convergent approach. Doubling of molecular length at each iteration

    NASA Astrophysics Data System (ADS)

    Pearson, Darren L.; Schumm, Jeffry S.; Jones, Leroy, II; Tour, James M.

    1994-06-01

    We have devised an iterative convergent/divergent approach to conjugated oligomers that might serve as molecular wires. The molecular length doubles with each iteration. The systems prepared are completely monodispersed and based upon oligo(thiophene-ethynylene)s (1) and oligo(phenylene-ethynylene)s at 100 A and 128 A long, respectively. The optical and size exclusion chromatography (SEC) properties are discussed. Methods are outlined to attach end groups that might serve as molecular alligator clips.

  16. Vagus Nerve Stimulation

    PubMed Central

    Howland, Robert H.

    2014-01-01

    The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuroendocrine-immune axis to maintain homeostasis through its afferent and efferent pathways. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, including manual or electrical stimulation. Left cervical VNS is an approved therapy for refractory epilepsy and for treatment resistant depression. Right cervical VNS is effective for treating heart failure in preclinical studies and a phase II clinical trial. The effectiveness of various forms of non-invasive transcutaneous VNS for epilepsy, depression, primary headaches, and other conditions has not been investigated beyond small pilot studies. The relationship between depression, inflammation, metabolic syndrome, and heart disease might be mediated by the vagus nerve. VNS deserves further study for its potentially favorable effects on cardiovascular, cerebrovascular, metabolic, and other physiological biomarkers associated with depression morbidity and mortality. PMID:24834378

  17. DIII-D Research in Support of ITER

    SciTech Connect

    Strait, E

    2008-10-14

    DIII-D research is providing key information for the design and operation of ITER. Discharges that simulate ITER operating scenarios in conventional H-mode, advanced inductive, hybrid, and steady state regimes have achieved normalized performance consistent with ITER's goals for fusion performance. Stationary discharges with high {beta}{sub N} and 90% noninductive current that project to Q=5 in ITER have been sustained for a current relaxation time ({approx}2.5 s), and high-beta wall-stabilized discharges with fully non-inductive current drive have been sustained for more than one second. Detailed issues of plasma control have been addressed, including the development of a new large-bore startup scenario for ITER. A broad research program provides the physics basis for predicting the performance of ITER. Recent key results include the discovery that the L-H power threshold is reduced with low neutral beam torque, and the development of a successful model for prediction of the H-mode pedestal height in DIII-D. Research areas with the potential to improve ITER's performance include the demonstration of ELM-free 'QH-mode' discharges with both co and counter-injection, and validation of the predicted torque generated by static, non-axisymmetric magnetic fields. New diagnostics provide detailed benchmarking of turbulent transport codes and direct measurements of the anomalous transport of fast ions by Alfven instabilities. DIII-D research also contributes to the basis for reliable operation in ITER, through active control of the chief performance-limiting instabilities. Recently, ELM suppression with resonant magnetic perturbations has been demonstrated at collisionality similar to ITER's, while simultaneous stabilization of NTMs (by localized current drive) and RWMs (by magnetic feedback) has allowed stable operation at high beta and low rotation. In research aimed at improving the lifetime of material surfaces near the plasma, recent experiments have investigated

  18. New York Canyon Stimulation

    SciTech Connect

    Raemy, Bernard

    2012-06-21

    The New York Canyon Stimulation Project was to demonstrate the commercial application of Enhanced Geothermal System techniques in Buena Vista Valley area of Pershing County, Nevada. From October 2009 to early 2012, TGP Development Company aggressively implemented Phase I of Pre-Stimulation and Site/Wellbore readiness. This included: geological studies; water studies and analyses and procurement of initial permits for drilling. Oversubscription of water rights and lack of water needed for implementation of EGS were identified and remained primary obstacles. Despite extended efforts to find alternative solutions, the water supply circumstances could not be overcome and led TGP to determine a "No Go" decision and initiate project termination in April 2012.

  19. Muscle Stimulation Technology

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Under a Goddard Space Flight Center contract, Electrologic of America was able to refine the process of densely packing circuitry on personal computer boards, providing significant contributions to the closed-loop systems for the Remote Manipulator System Simulator. The microcircuitry work was then applied to the StimMaster FES Ergometer, an exercise device used to stimulate muscles suffering from paralysis. The electrical stimulation equipment was developed exclusively for V-Care Health Systems, Inc. Product still commercially available as of March 2002.

  20. Negative Ion Based Heating and Diagnostic Neutral Beams for ITER

    NASA Astrophysics Data System (ADS)

    Schunke, B.; Bora, D.; Antoni, V.; Bonicelli, T.; Chakraborty, A.; Cordier, J.-J.; Hemsworth, R.; Inoue, T.; Tanga, A.; Watanabe, K.

    2008-04-01

    To meet the requirements of the four operating and one start-up scenarios foreseen in the International Tokamak Experimental Reactor (ITER) a flexible heating mix will be required, which has to include a reliable contribution from neutral beams. The current baseline of ITER foresees 2 Heating Neutral Beam (HNB) systems based on negative ion technology, each operating at 1 MeV 40 A D- ions, and each capable of delivering up to 16.7 MW of D ° to the ITER plasma. A 3rd HNB injector is foreseen as an upgrade option. In addition a dedicated Diagnostic Neutral Beam (DNB) injecting 100 keV 60 A of negative hydrogen ions will be available for charge exchange resonant spectroscopy (CXRS). The significant R&D effort necessary to meet the design requirements will be provided in the Neutral Beam Test Facility (NBTF), which is to be constructed in Padua, Italy. This paper gives an overview of the current status of the neutral beam (NB) systems and the chosen configuration. The ongoing integration effort into the ITER plant is highlighted and open interface issues are identified. It is shown how installation and maintenance logistics has influenced the design. ITER operating scenarios are briefly discussed, including start-up and commissioning. For example it is now envisaged to have a low current hydrogen phase of ITER operations, essentially for commissioning of the many auxiliary systems used on ITER. The low current limits the achievable plasma density, and hence the NB energy due to shine through limitations. Therefore a possible reconfiguration of the auxiliary heating systems is now being discussed. Other NB related issues identified by the ongoing design review process are emphasized and possible impact on the implementations of the HNB and DNB systems is indicated.

  1. Integrating Low-Cost Rapid Usability Testing into Agile System Development of Healthcare IT: A Methodological Perspective.

    PubMed

    Kushniruk, Andre W; Borycki, Elizabeth M

    2015-01-01

    The development of more usable and effective healthcare information systems has become a critical issue. In the software industry methodologies such as agile and iterative development processes have emerged to lead to more effective and usable systems. These approaches highlight focusing on user needs and promoting iterative and flexible development practices. Evaluation and testing of iterative agile development cycles is considered an important part of the agile methodology and iterative processes for system design and re-design. However, the issue of how to effectively integrate usability testing methods into rapid and flexible agile design cycles has remained to be fully explored. In this paper we describe our application of an approach known as low-cost rapid usability testing as it has been applied within agile system development in healthcare. The advantages of the integrative approach are described, along with current methodological considerations. PMID:25991130

  2. Integrating Low-Cost Rapid Usability Testing into Agile System Development of Healthcare IT: A Methodological Perspective.

    PubMed

    Kushniruk, Andre W; Borycki, Elizabeth M

    2015-01-01

    The development of more usable and effective healthcare information systems has become a critical issue. In the software industry methodologies such as agile and iterative development processes have emerged to lead to more effective and usable systems. These approaches highlight focusing on user needs and promoting iterative and flexible development practices. Evaluation and testing of iterative agile development cycles is considered an important part of the agile methodology and iterative processes for system design and re-design. However, the issue of how to effectively integrate usability testing methods into rapid and flexible agile design cycles has remained to be fully explored. In this paper we describe our application of an approach known as low-cost rapid usability testing as it has been applied within agile system development in healthcare. The advantages of the integrative approach are described, along with current methodological considerations.

  3. A Novel Compressed Sensing Method for Magnetic Resonance Imaging: Exponential Wavelet Iterative Shrinkage-Thresholding Algorithm with Random Shift.

    PubMed

    Zhang, Yudong; Yang, Jiquan; Yang, Jianfei; Liu, Aijun; Sun, Ping

    2016-01-01

    Aim. It can help improve the hospital throughput to accelerate magnetic resonance imaging (MRI) scanning. Patients will benefit from less waiting time. Task. In the last decade, various rapid MRI techniques on the basis of compressed sensing (CS) were proposed. However, both computation time and reconstruction quality of traditional CS-MRI did not meet the requirement of clinical use. Method. In this study, a novel method was proposed with the name of exponential wavelet iterative shrinkage-thresholding algorithm with random shift (abbreviated as EWISTARS). It is composed of three successful components: (i) exponential wavelet transform, (ii) iterative shrinkage-thresholding algorithm, and (iii) random shift. Results. Experimental results validated that, compared to state-of-the-art approaches, EWISTARS obtained the least mean absolute error, the least mean-squared error, and the highest peak signal-to-noise ratio. Conclusion. EWISTARS is superior to state-of-the-art approaches. PMID:27066068

  4. A Novel Compressed Sensing Method for Magnetic Resonance Imaging: Exponential Wavelet Iterative Shrinkage-Thresholding Algorithm with Random Shift

    PubMed Central

    Zhang, Yudong; Yang, Jiquan; Yang, Jianfei; Liu, Aijun; Sun, Ping

    2016-01-01

    Aim. It can help improve the hospital throughput to accelerate magnetic resonance imaging (MRI) scanning. Patients will benefit from less waiting time. Task. In the last decade, various rapid MRI techniques on the basis of compressed sensing (CS) were proposed. However, both computation time and reconstruction quality of traditional CS-MRI did not meet the requirement of clinical use. Method. In this study, a novel method was proposed with the name of exponential wavelet iterative shrinkage-thresholding algorithm with random shift (abbreviated as EWISTARS). It is composed of three successful components: (i) exponential wavelet transform, (ii) iterative shrinkage-thresholding algorithm, and (iii) random shift. Results. Experimental results validated that, compared to state-of-the-art approaches, EWISTARS obtained the least mean absolute error, the least mean-squared error, and the highest peak signal-to-noise ratio. Conclusion. EWISTARS is superior to state-of-the-art approaches. PMID:27066068

  5. Iterative solutions for one-dimensional diffusion with time varying surface composition and composition-dependent diffusion coefficient

    NASA Technical Reports Server (NTRS)

    Chow, M.; Houska, C. R.

    1980-01-01

    Solutions are given for one-dimensional diffusion problems with a time varying surface composition and also a composition dependent diffusion coefficient. The most general solution does not require special mathematical functions to fit the variation in surface composition or D(C). In another solution, a series expansion may be used to fit the time dependent surface concentration. These solutions make use of iterative calculations that converge rapidly and are highly stable. Computer times are much shorter than that required for finite difference calculations and can efficiently make use of interactive graphics terminals. Existing gas carburization data were used to provide an illustration of an iterative approach with a time varying carbon composition at the free surface.

  6. Extra-medical stimulant dependence among recent initiates

    PubMed Central

    O’Brien, Megan S.; Anthony, James C.

    2014-01-01

    New estimates for the risk of becoming stimulant dependent within 24 months after first extra-medical (EM) use of a stimulant drug compound are presented, with a focus on subgroup variations in this risk (e.g., alcohol dependence, male–female differences). The study estimates are derived from a representative sample of United States residents ages 12 and older (n = 166,737) obtained from the 2003 to 2005 National Surveys on Drug Use and Health. A total of 1700 respondents were found to have used stimulants extra-medically for the first time within 24 months prior to assessment. Approximately 5% of these recent-onset EM users had become stimulant dependent since onset of EM use. As hypothesized, alcohol dependence cases were found to have experienced an excess risk of becoming stimulant dependent soon after onset of stimulant drug use; there was no robust male–female difference in risk. Independently, initiates who had used multiple types of stimulants extra-medically, and methamphetamine users, were more likely to have become stimulant dependent soon after onset of use; by comparison, EM users of methylphenidate (Ritalin®) were less likely to have developed rapid-onset dependence. These epidemiologic findings help quantify a continuing public health burden associated with new onsets of extra-medical stimulant use in the 21st century. PMID:19515516

  7. ITER relevant testing of a cryogenic distillation column system

    SciTech Connect

    Bellamy, D.G.; Robins, J.R.; Woodall, K.B.; Sood, S.K.; Gierszewski, P.

    1995-10-01

    A new experimental system has been constructed to test ITER relevant distillation columns and related cryogenic distillation (CD) hardware and control systems. These columns are used to purify tritium in the ITER fuel cycle. The ITER test column reported here has a diameter of about 30 mm and a packed length of approximately 150 cm. It can operate with a hydrogen isotope (Q{sub 2}) boilup of about 60 watts. Two 30 W refrigeration systems were coupled together to deliver as close as possible to 60 watts of cooling. The separation performance of the column was determined by accurately measuring the tritium concentration in the feed and product streams using a mixture of D{sub 2} and DT gas. Conditions which yield a column theoretical plate height as low as 2.05 cm. and a plate inventory of 0.118 moles are reported. The goal of this research program is to measure the performance of ITER relevant columns, packings, condensers, and reboilers in order to minimize hydrogen (Q{sub 2}) and tritium holdup and to show that ITER objectives can be met with smaller diameter and lower tritium inventory columns than have previously been considered. 5 refs., 4 figs.

  8. ITER diagnostic systems in development in Ioffe Institute

    SciTech Connect

    Petrov, M.; Afanasyev, V.; Petrov, S.; Mironov, M.; Mukhin, E.; Tolstyakov, S.; Chugunov, I.; Shevelev, A.

    2014-08-21

    Three diagnostic systems are being developed in Ioffe Institute for ITER. Those are Neutral Particle Analysis (NPA), Thomson Scattering in Divertor (TSD) and Gamma Spectroscopy (GS). The main objective of NPA in ITER is to measure D/T fuel ration in plasma on the basis of measurement of neutralized fluxes of D and T ions [1]. Fuel ratio is one of the key parameters needed by ITER control system to provide the optimal conditions in plasma and the most effective plasma burning. Another objective is to measure the distribution function of fast ions (including alpha particles) generated as a result of the additional heating and nuclear fusion reactions. Thomson Scattering in Divertor (TSD) [2] will be used to measure electron temperature and density in the scrape-off layer in outer leg of ITER divertor. The main task of TSD is to protect the machine from divertor overloading. Gamma Spectroscopy (GS) [3] is based on the measurement of spectral lines of MeV range gammas generated in nuclear reactions in plasma. 2-D gamma-ray emission measurements give valuable information on the confined alpha particles in DT plasma. They also provide important information on the location of MeV range runaway electron beams in ITER plasma. For all three cases the physical basis and instrumentation are presented. The simple NPA version for measurements of D/T ratio in DEMO is also briefly described.

  9. Accelerate OPC convergence with new iteration control methodology

    NASA Astrophysics Data System (ADS)

    Wang, Ching-Heng; Liu, Qingwei; Zhang, Liguo

    2008-10-01

    A dilemmatic trade-off that all OPC engineers are facing everyday is the convergence of the OPC result and the control of the OPC iteration times. Theoretically, infinite times of OPC iterations are needed to achieve a convergent and stable correction result. But actually there should always be a cut-off for the iteration time, for turnaround- time is always an important criteria for IC fabs. But considering the design layout becomes more complicated and pattern density becomes higher with the shrinkage of the critical dimension, fragmentation control during the OPC procedure is also becoming more and more sophisticated. Thus, to achieve a convergent correction result for all OPC fragments within limited correction iteration times now becomes a big challenge to OPC engineers. This work presents our study in a new OPC iteration control methodology. It can help to find an algorithm that always converges, and reduce the excessive use of parameter setting, commands and other involvement by the user. With this, we can reduce the run time required to obtain a convergent OPC solution.

  10. NITSOL: A Newton iterative solver for nonlinear systems

    SciTech Connect

    Pernice, M.; Walker, H.F.

    1996-12-31

    Newton iterative methods, also known as truncated Newton methods, are implementations of Newton`s method in which the linear systems that characterize Newton steps are solved approximately using iterative linear algebra methods. Here, we outline a well-developed Newton iterative algorithm together with a Fortran implementation called NITSOL. The basic algorithm is an inexact Newton method globalized by backtracking, in which each initial trial step is determined by applying an iterative linear solver until an inexact Newton criterion is satisfied. In the implementation, the user can specify inexact Newton criteria in several ways and select an iterative linear solver from among several popular {open_quotes}transpose-free{close_quotes} Krylov subspace methods. Jacobian-vector products used by the Krylov solver can be either evaluated analytically with a user-supplied routine or approximated using finite differences of function values. A flexible interface permits a wide variety of preconditioning strategies and allows the user to define a preconditioner and optionally update it periodically. We give details of these and other features and demonstrate the performance of the implementation on a representative set of test problems.

  11. What does galvanic vestibular stimulation stimulate?

    PubMed

    Wardman, Daniel L; Fitzpatrick, Richard C

    2002-01-01

    The technique of galvanic vestibular stimulation (GVS) has been used for a long time. The stimulus produces stereotyped automatic postural and ocular responses. The mechanisms underlying these responses are not understood although they are commonly attributed to altered otolith output. Based on animal studies, it seems reasonable to assume that vestibular afferents from the otoliths and semicircular canals are affected similarly by GVS. With this assumption, and anatomical knowledge of the vestibular apparatus, a model is developed to describe the expected responses of vestibular afferents to percutaneous GVS and the physiological implications of this altered sensory signal. Bilateral bipolar GVS, the most commonly used technique, should produce a canal signal consistent with a strong ear-down roll towards the cathodal side, a smaller nose-to-cathode yaw, but no pitch signal. Bilateral bipolar GVS should also produce an otolith signal consistent with tilt towards the cathodal side or a translational acceleration towards the anodal side. The expected responses for other configurations of GVS are also described. The model appears consistent with published data on the ocular and postural responses to GVS, and suggests other testable hypotheses concerning postural, ocular and perceptual responses to GVS.

  12. Evolutionary dynamics of the continuous iterated prisoner's dilemma.

    PubMed

    Le, Stephen; Boyd, Robert

    2007-03-21

    The iterated prisoner's dilemma (IPD) has been widely used in the biological and social sciences to model dyadic cooperation. While most of this work has focused on the discrete prisoner's dilemma, in which actors choose between cooperation and defection, there has been some analysis of the continuous IPD, in which actors can choose any level of cooperation from zero to one. Here, we analyse a model of the continuous IPD with a limited strategy set, and show that a generous strategy achieves the maximum possible payoff against its own type. While this strategy is stable in a neighborhood of the equilibrium point, the equilibrium point itself is always vulnerable to invasion by uncooperative strategies, and hence subject to eventual destabilization. The presence of noise or errors has no effect on this result. Instead, generosity is favored because of its role in increasing contributions to the most efficient level, rather than in counteracting the corrosiveness of noise. Computer simulation using a single-locus infinite alleles Gaussian mutation model suggest that outcomes ranging from a stable cooperative polymorphism to complete collapse of cooperation are possible depending on the magnitude of the mutational variance. Also, making the cost of helping a convex function of the amount of help provided makes it more difficult for cooperative strategies to invade a non-cooperative equilibrium, and for the cooperative equilibrium to resist destabilization by non-cooperative strategies. Finally, we demonstrate that a much greater degree of assortment is required to destabilize a non-cooperative equilibrium in the continuous IPD than in the discrete IPD. The continuous model outlined here suggests that incremental amounts of cooperation lead to rapid decay of cooperation and thus even a large degree of assortment will not be sufficient to allow cooperation to increase when cooperators are rare. The extreme degree of assortment required to destabilize the non

  13. Transcranial brain stimulation: closing the loop between brain and stimulation

    PubMed Central

    Karabanov, Anke; Thielscher, Axel; Siebner, Hartwig Roman

    2016-01-01

    Purpose of review To discuss recent strategies for boosting the efficacy of noninvasive transcranial brain stimulation to improve human brain function. Recent findings Recent research exposed substantial intra- and inter-individual variability in response to plasticity-inducing transcranial brain stimulation. Trait-related and state-related determinants contribute to this variability, challenging the standard approach to apply stimulation in a rigid, one-size-fits-all fashion. Several strategies have been identified to reduce variability and maximize the plasticity-inducing effects of noninvasive transcranial brain stimulation. Priming interventions or paired associative stimulation can be used to ‘standardize’ the brain-state and hereby, homogenize the group response to stimulation. Neuroanatomical and neurochemical profiling based on magnetic resonance imaging and spectroscopy can capture trait-related and state-related variability. Fluctuations in brain-states can be traced online with functional brain imaging and inform the timing or other settings of transcranial brain stimulation. State-informed open-loop stimulation is aligned to the expression of a predefined brain state, according to prespecified rules. In contrast, adaptive closed-loop stimulation dynamically adjusts stimulation settings based on the occurrence of stimulation-induced state changes. Summary Approaches that take into account trait-related and state-related determinants of stimulation-induced plasticity bear considerable potential to establish noninvasive transcranial brain stimulation as interventional therapeutic tool. PMID:27224087

  14. Electrical stimulation vs. pulsed and continuous-wave optical stimulation of the rat prostate cavernous nerves, in vivo

    NASA Astrophysics Data System (ADS)

    Perkins, William C.; Lagoda, Gwen A.; Burnett, Arthur; Fried, Nathaniel M.

    2015-07-01

    Identification and preservation of the cavernous nerves (CNs) during prostate cancer surgery is critical for post-operative sexual function. Electrical nerve stimulation (ENS) mapping has previously been tested as an intraoperative tool for CN identification, but was found to be unreliable. ENS is limited by the need for electrode-tissue contact, poor spatial precision from electrical current spreading, and stimulation artifacts interfering with detection. Alternatively, optical nerve stimulation (ONS) provides noncontact stimulation, improved spatial selectivity, and elimination of stimulation artifacts. This study compares ENS to pulsed/CW ONS to explore the ONS mechanism. A total of eighty stimulations were performed in 5 rats, in vivo. ENS (4 V, 5 ms, 10 Hz) was compared to ONS using a pulsed diode laser nerve stimulator (1873 nm, 5 ms, 10 Hz) or CW diode laser nerve stimulator (1455 nm). Intracavernous pressure (ICP) response and nerve compound action potentials (nCAPs) were measured. All three stimulation modes (ENS, ONS-CW, ONS-P) produced comparable ICP magnitudes. However, ENS demonstrated more rapid ICP response times and well defined nCAPs compared to unmeasurable nCAPs for ONS. Further experiments measuring single action potentials during ENS and ONS are warranted to further understand differences in the ENS and ONS mechanisms.

  15. Rapid Reading, Yes

    ERIC Educational Resources Information Center

    Frommer, Harvey

    1971-01-01

    Recommends instruction in rapid reading fo high school and college students and asserts that flexibility of speed and reasoning provide the foundation for effective rapid reading. Describes the components of rapid reading as orientation, selection, clarification, arrangement, review, and study. (RW)

  16. Diamond neutral particle spectrometer for fusion reactor ITER

    SciTech Connect

    Krasilnikov, V.; Amosov, V.; Kaschuck, Yu.; Skopintsev, D.

    2014-08-21

    A compact diamond neutral particle spectrometer with digital signal processing has been developed for fast charge-exchange atoms and neutrons measurements at ITER fusion reactor conditions. This spectrometer will play supplementary role for Neutral Particle Analyzer providing 10 ms time and 30 keV energy resolutions for fast particle spectra in non-tritium ITER phase. These data will also be implemented for independent studies of fast ions distribution function evolution in various plasma scenarios with the formation of a single fraction of high-energy ions. In tritium ITER phase the DNPS will measure 14 MeV neutrons spectra. The spectrometer with digital signal processing can operate at peak counting rates reaching a value of 10{sup 6} cps. Diamond neutral particle spectrometer is applicable to future fusion reactors due to its high radiation hardness, fast response and high energy resolution.

  17. ITER Scenario Performance Simulations Assessing Control and Vertical Stability

    SciTech Connect

    Casper, T; Ferron, J; Humphreys, D; Jackson, G; Leuer, J; LoDestro, L; Luce, T; Meyer, W; Pearlstein, L; Welander, A

    2008-05-20

    In simulating reference scenarios proposed for ITER operation, we also explore performance of the poloidal field (PF) and central solenoid (CS) coil systems using a controller to maintain plasma shape and vertical stability during the discharge evolution. We employ a combination of techniques to evaluate system constraints and stability using time-dependent transport simulations of ITER discharges. We have begun the process of benchmarking these simulations with experiments on the DIII-D tokamak. Simulations include startup on the outside limiter, X-point formation and current ramp up to full power, plasma burn conditions at 15MA and 17MA, and ramp down at the end of the pulse. We also simulate perturbative events such as H-to-L back transitions. Our results indicate the viability of proposed ITER operating modes.

  18. Tooling concepts for ITER tokamak assembly and remote disassembly

    SciTech Connect

    Oikawa, A.; Puhn, F.; Helary, J.L.; Shaw, R.; Friend, M.; Piec, Z.; Tachikawa, N.; Acks, M.; Basile, A.

    1995-12-31

    Since ITER has many of the characteristics of a full-scale tokamak reactor, its provisions for assembly and replaceability are relevant to a future fusion power plant. The performance of ITER is dependent on tight tolerances, mainly for the magnets and plasma facing components. The magnetic field must be highly uniform in the toroidal direction to ensure good plasma energy and particle confinement. Alignment of the plasma facing surface of the first wall and divertor target plates is required to avoid large local heat loads on the plasma facing components and, as a consequence, their erosion and contamination of the plasma with impurities. Because of the large and heavy components the major challenge of the ITER tokamak assembly is to hold such tight tolerances using guide tools, adjustable interfaces, accurate measuring tools, and specific procedures to compensate for deformation and fabrication tolerances. The assembly tooling plan also includes verification of the essential remote handling operations.

  19. RHIC D0 INSERTION DIPOLE DESIGN ITERATIONS DURING PRODUCTION.

    SciTech Connect

    SCHMALZLE,J.; ANERELLA,M.; GANETIS,G.; GHOSH,A.; GUPTA,R.; JAIN,A.; KAHN,S.; MORGAN,G.; MURATORE,J.; SAMPSON,W.; WANDERER,P.; WILLEN,E.

    1997-05-12

    Iterations to the cross section of the Relativistic Heavy Ion Collider (RHIC) D0 Insertion Dipole magnets were made during the production. This was included as part of the production plan because no R&D or pre-production magnets were built prior to the start of production. The first magnet produced had the desired coil pre-stress and low field harmonics in the body of the magnet and is therefore being used in the RHIC Machine. On the first eight magnets, iterations were carried out to minimize the iron saturation and to compensate for the end harmonics. This paper will discuss the details of the iterations made, the obstacles encountered, and the results obtained. Also included will be a brief summary of the magnet design and performance.

  20. Tomography by iterative convolution - Empirical study and application to interferometry

    NASA Technical Reports Server (NTRS)

    Vest, C. M.; Prikryl, I.

    1984-01-01

    An algorithm for computer tomography has been developed that is applicable to reconstruction from data having incomplete projections because an opaque object blocks some of the probing radiation as it passes through the object field. The algorithm is based on iteration between the object domain and the projection (Radon transform) domain. Reconstructions are computed during each iteration by the well-known convolution method. Although it is demonstrated that this algorithm does not converge, an empirically justified criterion for terminating the iteration when the most accurate estimate has been computed is presented. The algorithm has been studied by using it to reconstruct several different object fields with several different opaque regions. It also has been used to reconstruct aerodynamic density fields from interferometric data recorded in wind tunnel tests.

  1. Preconditioning methods for improved convergence rates in iterative reconstructions

    SciTech Connect

    Clinthorne, N.H.; Chiao, Pingchun; Rogers, W.L. . Div. of Nuclear Medicine); Pan, T.S. . Dept. of Nuclear Medicine); Stamos, J.A. . Dept. of Nuclear Engineering)

    1993-03-01

    Because of the characteristics of the tomographic inversion problem, iterative reconstruction techniques often suffer from poor convergence rates--especially at high spatial frequencies. By using preconditioning methods, the convergence properties of most iterative methods can be greatly enhanced without changing their ultimate solution. To increase reconstruction speed, the authors have applied spatially-invariant preconditioning filters that can be designed using the tomographic system response and implemented using 2-D frequency-domain filtering techniques. In a sample application, the authors performed reconstructions from noiseless, simulated projection data, using preconditioned and conventional steepest-descent algorithms. The preconditioned methods demonstrated residuals that were up to a factor of 30 lower than the unassisted algorithms at the same iteration. Applications of these methods to regularized reconstructions from projection data containing Poisson noise showed similar, although not as dramatic, behavior.

  2. Shape reanalysis and sensitivities utilizing preconditioned iterative boundary solvers

    NASA Technical Reports Server (NTRS)

    Guru Prasad, K.; Kane, J. H.

    1992-01-01

    The computational advantages associated with the utilization of preconditined iterative equation solvers are quantified for the reanalysis of perturbed shapes using continuum structural boundary element analysis (BEA). Both single- and multi-zone three-dimensional problems are examined. Significant reductions in computer time are obtained by making use of previously computed solution vectors and preconditioners in subsequent analyses. The effectiveness of this technique is demonstrated for the computation of shape response sensitivities required in shape optimization. Computer times and accuracies achieved using the preconditioned iterative solvers are compared with those obtained via direct solvers and implicit differentiation of the boundary integral equations. It is concluded that this approach employing preconditioned iterative equation solvers in reanalysis and sensitivity analysis can be competitive with if not superior to those involving direct solvers.

  3. Three Dimensional Iterative Reconstruction Techniques in Positron Tomography.

    NASA Astrophysics Data System (ADS)

    Sloka, Scott

    The acquisition of positron tomographic data in three dimensions is an improvement over the two dimensional acquisition of data because the greater the number of measurements taken of a stochastic process, the more accurately determined the desired parameter may be. This research pursues the goal of three dimensional image reconstruction in Positron Tomography using an iterative approach. This thesis has followed a systematic approach to the exploration of a system for three dimensional iterative reconstruction. System design parameters were discussed such as the advantages and disadvantages of iterative vs analytic methods, the implementation of two, three dimensional iterative algorithms, the selection of a ray passing method, and the choice of an analytic method for comparison to the iterative methods. Several qualitative and quantitative tests were used/developed and performed to analyse and compare the results. Three dimensional reconstruction in Positron Tomography using two iterative techniques (ART and ML-EM) was demonstrated. The ML-EM algorithm was adapted to satisfy the objective of equalizing the estimates with the measurements via division of the sampling density. A new multi-objective function methodology was developed for two dimensions and its extension to three dimensions discussed. A smoothly-varying Gaussian phantom was created for comparing artifacts from different ray passing methods. The analysis of voxel trends over many iterations was used. The use of the output from a two dimensional filtered backprojection algorithm as the seed for three dimensional algorithms to accelerate the reconstruction the was explored. The importance of the selection of a good ray ordering in ART and its effects on the total squared error were explored. For the phantoms studied in this thesis, the ML -EM algorithm tended to perform better under most conditions. This algorithm is slower than ART to achieve both a low total squared error and good contrast, but the

  4. Iterative methods for plasma sheath calculations: Application to spherical probe

    NASA Technical Reports Server (NTRS)

    Parker, L. W.; Sullivan, E. C.

    1973-01-01

    The computer cost of a Poisson-Vlasov iteration procedure for the numerical solution of a steady-state collisionless plasma-sheath problem depends on: (1) the nature of the chosen iterative algorithm, (2) the position of the outer boundary of the grid, and (3) the nature of the boundary condition applied to simulate a condition at infinity (as in three-dimensional probe or satellite-wake problems). Two iterative algorithms, in conjunction with three types of boundary conditions, are analyzed theoretically and applied to the computation of current-voltage characteristics of a spherical electrostatic probe. The first algorithm was commonly used by physicists, and its computer costs depend primarily on the boundary conditions and are only slightly affected by the mesh interval. The second algorithm is not commonly used, and its costs depend primarily on the mesh interval and slightly on the boundary conditions.

  5. A successive overrelaxation iterative technique for an adaptive equalizer

    NASA Technical Reports Server (NTRS)

    Kosovych, O. S.

    1973-01-01

    An adaptive strategy for the equalization of pulse-amplitude-modulated signals in the presence of intersymbol interference and additive noise is reported. The successive overrelaxation iterative technique is used as the algorithm for the iterative adjustment of the equalizer coefficents during a training period for the minimization of the mean square error. With 2-cyclic and nonnegative Jacobi matrices substantial improvement is demonstrated in the rate of convergence over the commonly used gradient techniques. The Jacobi theorems are also extended to nonpositive Jacobi matrices. Numerical examples strongly indicate that the improvements obtained for the special cases are possible for general channel characteristics. The technique is analytically demonstrated to decrease the mean square error at each iteration for a large range of parameter values for light or moderate intersymbol interference and for small intervals for general channels. Analytically, convergence of the relaxation algorithm was proven in a noisy environment and the coefficient variance was demonstrated to be bounded.

  6. Topological quantum gate construction by iterative pseudogroup hashing

    NASA Astrophysics Data System (ADS)

    Burrello, Michele; Mussardo, Giuseppe; Wan, Xin

    2011-02-01

    We describe the hashing technique for obtaining a fast approximation of a target quantum gate in the unitary group SU(2) represented by a product of the elements of a universal basis. The hashing exploits the structure of the icosahedral group (or other finite subgroups of SU(2)) and its pseudogroup approximations to reduce the search within a small number of elements. One of the main advantages of the pseudogroup hashing is the possibility of iterating to obtain more accurate representations of the targets in the spirit of the renormalization group approach. We describe the iterative pseudogroup hashing algorithm using the universal basis given by the braidings of Fibonacci anyons. An analysis of the efficiency of the iterations based on the random matrix theory indicates that the runtime and braid length scale poly-logarithmically with the final error, comparing favorably to the Solovay-Kitaev algorithm.

  7. Partial iterated function system-based fractal image coding

    NASA Astrophysics Data System (ADS)

    Wang, Zhou; Yu, Ying Lin

    1996-06-01

    A recent trend in computer graphics and image processing has been to use iterated function system (IFS) to generate and describe images. Barnsley et al. presented the conception of fractal image compression and Jacquin was the first to propose a fully automatic gray scale still image coding algorithm. This paper introduces a generalization of basic IFS, leading to a conception of partial iterated function system (PIFS). A PIFS operator is contractive under certain conditions and when it is applied to generate an image, only part of it is actually iteratedly applied. PIFS provides us a flexible way to combine fractal coding with other image coding techniques and many specific algorithms can be derived from it. On the basis of PIFS, we implement a partial fractal block coding (PFBC) algorithm and compare it with basic IFS based fractal block coding algorithm. Experimental results show that coding efficiency is improved and computation time is reduced while image fidelity does not degrade very much.

  8. Space Charge Neutralization in the ITER Negative Ion Beams

    SciTech Connect

    Surrey, Elizabeth

    2007-08-10

    A model of the space charge neutralization of negative ion beams, developed from the model due to Holmes, is applied to the ITER heating and diagnostic beams. The Holmes model assumed that the plasma electron temperature was derived from the stripped electrons. This is shown to be incorrect for the ITER beams and the plasma electron temperature is obtained from the average creation energy upon ionization. The model shows that both ITER beams will be fully space charge compensated in the drift distance between the accelerator and the neutralizer. Inside the neutralizer, the plasma over compensates the space charge to the extent that a significant focusing force is predicted. At a certain position in the neutraliser this force balances the defocusing force due to the ions' transverse energy. Under these conditions the beam distribution function can change from Gaussian to Bennett and evidence of such a distribution observed in a multi-aperture, neutralized negative ion beam is presented.

  9. Impact of W on scenario simulations for ITER

    NASA Astrophysics Data System (ADS)

    Hogeweij, G. M. D.; Leonov, V.; Schweinzer, J.; Sips, A. C. C.; Angioni, C.; Calabrò, G.; Dux, R.; Kallenbach, A.; Lerche, E.; Maggi, C.; Pütterich, Th.; ITPA Integrated Operating Scenarios topical Group; ASDEX Upgrade Team; Contributors, JET

    2015-06-01

    In preparation of ITER operation, large machines have replaced their wall and divertor material to W (ASDEX Upgrade) or a combination of Be for the wall and W for the divertor (JET). Operation in these machines has shown that the influx of W can have a significant impact on the discharge evolution, which has made modelling of this impact for ITER an urgent task. This paper reports on such modelling efforts. Maximum tolerable W concentrations have been determined for various scenarios, both for the current ramp-up and flat-top phase. Results of two independent methods are presented, based on the codes ZIMPUR plus ASTRA and CRONOS, respectively. Both methods have been tested and benchmarked against ITER-like Ip RU experiments at JET. It is found that W significantly disturbs the discharge evolution when the W concentration approaches ˜10-4 this critical level varies somewhat between scenarios.

  10. Diamond neutral particle spectrometer for fusion reactor ITER

    NASA Astrophysics Data System (ADS)

    Krasilnikov, V.; Amosov, V.; Kaschuck, Yu.; Skopintsev, D.

    2014-08-01

    A compact diamond neutral particle spectrometer with digital signal processing has been developed for fast charge-exchange atoms and neutrons measurements at ITER fusion reactor conditions. This spectrometer will play supplementary role for Neutral Particle Analyzer providing 10 ms time and 30 keV energy resolutions for fast particle spectra in non-tritium ITER phase. These data will also be implemented for independent studies of fast ions distribution function evolution in various plasma scenarios with the formation of a single fraction of high-energy ions. In tritium ITER phase the DNPS will measure 14 MeV neutrons spectra. The spectrometer with digital signal processing can operate at peak counting rates reaching a value of 106 cps. Diamond neutral particle spectrometer is applicable to future fusion reactors due to its high radiation hardness, fast response and high energy resolution.

  11. Experiment of low resistance joints for the ITER correction coil.

    PubMed

    Liu, Huajun; Wu, Yu; Wu, Weiyue; Liu, Bo; Shi, Yi; Guo, Shuai

    2013-01-01

    A test method was designed and performed to measure joint resistance of the ITER correction coil (CC) in liquid helium (LHe) temperature. A 10 kA superconducting transformer was manufactured to provide the joints current. The transformer consisted of two concentric layer-wound superconducting solenoids. NbTi superconducting wire was wound in the primary coil and the ITER CC conductor was wound in the secondary coil. The primary and the secondary coils were both immersed in liquid helium of a 300 mm useful bore diameter cryostat. Two ITER CC joints were assembled in the secondary loop and tested. The current of the secondary loop was ramped to 9 kA in several steps. The two joint resistances were measured to be 1.2 nΩ and 1.65 nΩ, respectively.

  12. Description of the prototype diagnostic residual gas analyzer for ITER.

    PubMed

    Younkin, T R; Biewer, T M; Klepper, C C; Marcus, C

    2014-11-01

    The diagnostic residual gas analyzer (DRGA) system to be used during ITER tokamak operation is being designed at Oak Ridge National Laboratory to measure fuel ratios (deuterium and tritium), fusion ash (helium), and impurities in the plasma. The eventual purpose of this instrument is for machine protection, basic control, and physics on ITER. Prototyping is ongoing to optimize the hardware setup and measurement capabilities. The DRGA prototype is comprised of a vacuum system and measurement technologies that will overlap to meet ITER measurement requirements. Three technologies included in this diagnostic are a quadrupole mass spectrometer, an ion trap mass spectrometer, and an optical penning gauge that are designed to document relative and absolute gas concentrations.

  13. Description of the prototype diagnostic residual gas analyzer for ITER

    SciTech Connect

    Younkin, T. R.; Biewer, T. M.; Klepper, C. C.; Marcus, C.

    2014-11-15

    The diagnostic residual gas analyzer (DRGA) system to be used during ITER tokamak operation is being designed at Oak Ridge National Laboratory to measure fuel ratios (deuterium and tritium), fusion ash (helium), and impurities in the plasma. The eventual purpose of this instrument is for machine protection, basic control, and physics on ITER. Prototyping is ongoing to optimize the hardware setup and measurement capabilities. The DRGA prototype is comprised of a vacuum system and measurement technologies that will overlap to meet ITER measurement requirements. Three technologies included in this diagnostic are a quadrupole mass spectrometer, an ion trap mass spectrometer, and an optical penning gauge that are designed to document relative and absolute gas concentrations.

  14. Novel transcranial magnetic stimulation coil for mice

    NASA Astrophysics Data System (ADS)

    March, Stephen; Stark, Spencer; Crowther, Lawrence; Hadimani, Ravi; Jiles, David

    2014-03-01

    Transcranial magnetic stimulation (TMS) shows potential for non-invasive treatment of various neurological disorders. Significant work has been performed on the design of coils used for TMS on human subjects but few reports have been made on the design of coils for use on the brains of animals such as mice. This work is needed as TMS studies utilizing mice can allow rapid preclinical development of TMS for human disorders but the coil designs developed for use on humans are inadequate for optimal stimulation of the much smaller mouse brain. A novel TMS coil has been developed with the goal of inducing strong and focused electric fields for the stimulation of small animals such as mice. Calculations of induced electric fields were performed utilizing an MRI derived inhomogeneous model of an adult male mouse. Mechanical and thermal analysis of this new TMS helmet-coil design have also been performed at anticipated TMS operating conditions to ensure mechanical stability of the new coil and establish expected linear attraction and rotational force values. Calculated temperature increases for typical stimulation periods indicate the helmet-coil system is capable of operating within established medical standards. A prototype of the coil has been fabricated and characterization results are presented.

  15. Research and development needs for ITER engineering design

    NASA Astrophysics Data System (ADS)

    Flanagan, C.

    1991-08-01

    In the series of documents that summarize the results of the Conceptual Design Activities (CDA) for the International Thermonuclear Experimental Reactor (ITER), this document describes the research and development (R and D) plans for 1991 - 1995. Part A describes the physics R and D, and Part B the technology R and D. The physics R and D needs are presented in terms of task descriptions of an ITER-related R and D program for 1991/1992 and beyond, while diagnostics R and D needs, although covered in Appendix A, are described in Part B. In Chapter 2 of Part A, 'ITER-related Physics R and D Needs for 91/92 and Beyond', the following tasks are described as most crucial: (1) demonstration that (a) operation with a cold divertor plasma is possible, (b) the peak heat flux onto the divertor plate can be kept below about 10 MW per square meter, and (c) helium exhaust conditions allow a fractional burnup of about three percent or more; (2) a characterization of disruptions that allows to specify their consequences for the plasma-facing-components, and that provides evidence that the number of disruptions expected allows acceptable plasma-facing-component lifetimes; (3) demonstration that steady-state operation in an enhanced-confinement regime and satisfactory plasma purity is possible, and provision of energy confinement scaling allowing the prediction of ITER performance; and (4) ensurance that the presence of a fast ion population does not jeopardize plasma performance in ITER. Part B, 'ITER Technology Research and Development Needs', describes planning R and D for magnets, containment structure, assembly and maintenance, current drive and heating, plasma facing components, blanket, fuel cycle, structural materials, and diagnostics. A table of key milestones for technology R and D is included, as well as cost estimates.

  16. Migration of vectorized iterative solvers to distributed memory architectures

    SciTech Connect

    Pommerell, C.; Ruehl, R.

    1994-12-31

    Both necessity and opportunity motivate the use of high-performance computers for iterative linear solvers. Necessity results from the size of the problems being solved-smaller problems are often better handled by direct methods. Opportunity arises from the formulation of the iterative methods in terms of simple linear algebra operations, even if this {open_quote}natural{close_quotes} parallelism is not easy to exploit in irregularly structured sparse matrices and with good preconditioners. As a result, high-performance implementations of iterative solvers have attracted a lot of interest in recent years. Most efforts are geared to vectorize or parallelize the dominating operation-structured or unstructured sparse matrix-vector multiplication, or to increase locality and parallelism by reformulating the algorithm-reducing global synchronization in inner products or local data exchange in preconditioners. Target architectures for iterative solvers currently include mostly vector supercomputers and architectures with one or few optimized (e.g., super-scalar and/or super-pipelined RISC) processors and hierarchical memory systems. More recently, parallel computers with physically distributed memory and a better price/performance ratio have been offered by vendors as a very interesting alternative to vector supercomputers. However, programming comfort on such distributed memory parallel processors (DMPPs) still lags behind. Here the authors are concerned with iterative solvers and their changing computing environment. In particular, they are considering migration from traditional vector supercomputers to DMPPs. Application requirements force one to use flexible and portable libraries. They want to extend the portability of iterative solvers rather than reimplementing everything for each new machine, or even for each new architecture.

  17. A new iterative triclass thresholding technique in image segmentation.

    PubMed

    Cai, Hongmin; Yang, Zhong; Cao, Xinhua; Xia, Weiming; Xu, Xiaoyin

    2014-03-01

    We present a new method in image segmentation that is based on Otsu's method but iteratively searches for subregions of the image for segmentation, instead of treating the full image as a whole region for processing. The iterative method starts with Otsu's threshold and computes the mean values of the two classes as separated by the threshold. Based on the Otsu's threshold and the two mean values, the method separates the image into three classes instead of two as the standard Otsu's method does. The first two classes are determined as the foreground and background and they will not be processed further. The third class is denoted as a to-be-determined (TBD) region that is processed at next iteration. At the succeeding iteration, Otsu's method is applied on the TBD region to calculate a new threshold and two class means and the TBD region is again separated into three classes, namely, foreground, background, and a new TBD region, which by definition is smaller than the previous TBD regions. Then, the new TBD region is processed in the similar manner. The process stops when the Otsu's thresholds calculated between two iterations is less than a preset threshold. Then, all the intermediate foreground and background regions are, respectively, combined to create the final segmentation result. Tests on synthetic and real images showed that the new iterative method can achieve better performance than the standard Otsu's method in many challenging cases, such as identifying weak objects and revealing fine structures of complex objects while the added computational cost is minimal.

  18. Electromechanical Nerve Stimulator

    NASA Technical Reports Server (NTRS)

    Tcheng, Ping; Supplee, Frank H., Jr.; Prass, Richard L.

    1993-01-01

    Nerve stimulator applies and/or measures precisely controlled force and/or displacement to nerve so response of nerve measured. Consists of three major components connected in tandem: miniature probe with spherical tip; transducer; and actuator. Probe applies force to nerve, transducer measures force and sends feedback signal to control circuitry, and actuator positions force transducer and probe. Separate box houses control circuits and panel. Operator uses panel to select operating mode and parameters. Stimulator used in research to characterize behavior of nerve under various conditions of temperature, anesthesia, ventilation, and prior damage to nerve. Also used clinically to assess damage to nerve from disease or accident and to monitor response of nerve during surgery.

  19. Optically stimulated luminescence dosimetry

    NASA Astrophysics Data System (ADS)

    McKeever, Stephen W.

    1999-02-01

    Optically Stimulated Luminescence (OSL) dosimetry is attractive to the health physics and dosimetry community due to its all-optical character, fast data acquisition and the avoidance of heating the detector. Until recently there was no luminescent material sensitive enough to radiation, and at the same time suitable for stimulation with visible light, for use in this application. However, anion-deficient aluminum oxide doped with carbon (Al2O3:C) appears to be not only an extremely sensitive thermoluminescence (TL) material, but is also well-suited to OSL applications. Several OSL readout protocols have been suggested, including cw-OSL, pulsed OSL (POSL), and 'delayed' OSL (DOSL). The paper discusses the physical mechanisms that give rise to the OSL signals and the dependence of these signals upon absorbed dose. Example applications of the use of OSL from Al2O3:C in environmental radiation and ultraviolet-B dosimetry are discussed.

  20. Sacral nerve stimulation.

    PubMed

    Matzel, K E; Stadelmaier, U; Besendörfer, M

    2004-01-01

    The current concept of recruiting residual function of an inadequate pelvic organ by electrostimulation involves stimulation of the sacral spinal nerves at the level of the sacral canal. The rationale for applying SNS to fecal incontinence was based on clinical observations of its effect on bowel habits and anorectal continence function in urologic patients (increased anorectal angulation and anal canal closure pressure) and on anatomic considerations: dissection demonstrated a dual peripheral nerve supply of the striated pelvic floor muscles that govern these functions. Because the sacral spinal nerve site is the most distal common location of this dual nerve supply, stimulating here can elicit both functions. Since the first application of SNS in fecal incontinence in 1994, this technique has been improved, the patient selection process modified, and the spectrum of indications expanded. At present SNS has been applied in more than 1300 patients with fecal incontinence limited.

  1. Cognitive stimulation in brainstorming.

    PubMed

    Dugosh, K L; Paulus, P B; Roland, E J; Yang, H C

    2000-11-01

    Research on group brainstorming has demonstrated that it is less effective for generating large numbers of ideas than individual brainstorming, yet various scholars have presumed that group idea sharing should enhance cognitive stimulation and idea production. Three experiments examined the potential of cognitive stimulation in brainstorming. Experiments 1 and 2 used a paradigm in which individuals were exposed to ideas on audiotape as they were brainstorming, and Experiment 3 used the electronic brainstorming paradigm. Evidence was obtained for enhanced idea generation both during and after idea exposure. The attentional set of the participant and the content of the exposure manipulation (number of ideas, presence of irrelevant information) influenced this effect. These results are consistent with a cognitive perspective on group brainstorming.

  2. Stimulated Raman photoacoustic imaging

    PubMed Central

    Yakovlev, Vladislav V.; Zhang, Hao F.; Noojin, Gary D.; Denton, Michael L.; Thomas, Robert J.; Scully, Marlan O.

    2010-01-01

    Achieving label-free, molecular-specific imaging with high spatial resolution in deep tissue is often considered the grand challenge of optical imaging. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. We demonstrate the feasibility of developing such an optical imaging modality by combining the molecularly specific stimulated Raman excitation with the photoacoustic detection. By employing two ultrashort excitation laser pulses, separated in frequency by the vibrational frequency of a targeted molecule, only the specific vibrational level of the target molecules in the illuminated tissue volume is excited. This targeted optical absorption generates ultrasonic waves (referred to as stimulated Raman photoacoustic waves) which are detected using a traditional ultrasonic transducer to form an image following the design of the established photoacoustic microscopy. PMID:21059930

  3. Experimental and theoretical studies of iterative methods for nonlinear, nonsymmetric systems arising in combustion

    SciTech Connect

    Hagstrom, T.; Radhakrishnan, K.

    1994-12-31

    The authors report on some iterative methods which they have tested for use in combustion simulations. In particular, they have developed a code to solve zero Mach number reacting flow equations with complex reaction and diffusion physics. These equations have the form of a nonlinear parabolic system coupled with constraints. In semi-discrete form, one obtains DAE`s of index two or three depending on the number of spatial dimensions. The authors have implemented a fourth order (fully implicit) BDF method in time, coupled with a suite of fourth order explicit and implicit spatial difference approximations. Most codes they know of for simulating reacting flows use a splitting strategy to march in time. This results in a sequence of nonlinear systems to solve, each of which has a simpler structure than the one they are faced with. The rapid and robust solution of the coupled system is the essential requirement for the success of their approach. They have implemented and analyzed nonlinear generalizations of conjugate gradient-like methods for nonsymmetric systems, including CGS and the quasi-Newton based method of Eirola and Nevanlinna. They develop a general framework for the nonlinearization of linear methods in terms of the acceleration of fixed-point iterations, where the latter is assumed to include the {open_quote}preconditioning{open_quote}. Their preconditioning is a single step of a split method, using lower order spatial difference approximations as well as simplified (Fickian) approximations of the diffusion physics.

  4. Simulation of High Power ICRF Wave Heating in the ITER Burning Plasma

    NASA Astrophysics Data System (ADS)

    Jaeger, E. F.; Berry, L. A.; Barrett, R. F.; D'Azevedo, E. F.

    2007-11-01

    ITER relies on Ion-cyclotron Radio Frequency (ICRF) power to heat the plasma to fusion temperatures. To heat effectively, the waves must couple efficiently to the core plasma. Recent simulations using AORSA [1] on the 120 TF Cray XT-4 (Jaguar) at ORNL show that the waves propagate radially inward and are rapidly absorbed with little heating of the plasma edge. AORSA has achieved 87.5 trillion calculations per second (87.5 teraflops) on Jaguar, which is 73 percent of the system's theoretical peak. Three dimensional visualizations show ``hot spots'' near the antenna surface where the wave amplitude is high. AORSA simulations are also being used to study how to best use ICRF to drive plasma currents for optimizing ITER performance and pulse length. Results for Scenario 4 show a maximum current of 0.54 MA for 20 MW of power at 57 MHz. [1] E.F. Jaeger, L.A. Berry, E. D'Azevedo, et al., Phys. Plasmas. 8, 1573 (2001).

  5. Tackling multi-pollutant multi-effect problems--an iterative approach.

    PubMed

    Simpson, D; Eliassen, A

    1999-08-30

    Within both the UN ECE and the European Union, there has been a strong move towards the so-called multi-pollutant multi-effect approach to air pollution strategies. In this approach a number of pollutants are considered, and emission reductions are determined after looking at the effect of each of these pollutants on a number of environmental problems. This new approach is very ambitious and raises a number of problems in balancing the effects and costs of different emission reductions against achieved environmental benefits. We describe an iterative method designed for addressing such multi-pollutant multi-effect type problems. In the examples given here, the method is used to estimate combinations of NOx and VOC emission reductions from all European countries so as to reduce environmental problems associated with acidification and ozone in a cost-effective manner. The iterative technique is designed to be flexible and transparent, so that a number of different approaches to multi-pollutant-multi-effect problems can be considered. This technique can be used to provide early guidance on various control strategy options, and allows rapid exploration of the many targets and measures possible with these approaches. It also demonstrates how even complex multi-dimensional environmental problems may be amenable to understandable solutions.

  6. Iterative ensemble Kalman filter for atmospheric dispersion in nuclear accidents: An application to Kincaid tracer experiment.

    PubMed

    Zhang, X L; Su, G F; Chen, J G; Raskob, W; Yuan, H Y; Huang, Q Y

    2015-10-30

    Information about atmospheric dispersion of radionuclides is vitally important for planning effective countermeasures during nuclear accidents. Results of dispersion models have high spatial and temporal resolutions, but they are not accurate enough due to the uncertain source term and the errors in meteorological data. Environmental measurements are more reliable, but they are scarce and unable to give forecasts. In this study, our newly proposed iterative ensemble Kalman filter (EnKF) data assimilation scheme is used to combine model results and environmental measurements. The system is thoroughly validated against the observations in the Kincaid tracer experiment. The initial first-guess emissions are assumed to be six magnitudes underestimated. The iterative EnKF system rapidly corrects the errors in the emission rate and wind data, thereby significantly improving the model results (>80% reduction of the normalized mean square error, r=0.71). Sensitivity tests are conducted to investigate the influence of meteorological parameters. The results indicate that the system is sensitive to boundary layer height. When the heights from the numerical weather prediction model are used, only 62.5% of reconstructed emission rates are within a factor two of the actual emissions. This increases to 87.5% when the heights derived from the on-site observations are used.

  7. STELLOPT Modeling of the 3D Diagnostic Response in ITER

    SciTech Connect

    Lazerson, Samuel A

    2013-05-07

    The ITER three dimensional diagnostic response to an n=3 resonant magnetic perturbation is modeled using the STELLOPT code. The in-vessel coils apply a resonant magnetic perturbation (RMP) fi eld which generates a 4 cm edge displacement from axisymmetry as modeled by the VMEC 3D equilibrium code. Forward modeling of flux loop and magnetic probe response with the DIAGNO code indicates up to 20 % changes in measured plasma signals. Simulated LIDAR measurements of electron temperature indicate 2 cm shifts on the low field side of the plasma. This suggests that the ITER diagnostic will be able to diagnose the 3D structure of the equilibria.

  8. Power Radiated from ITER and CIT by Impurities

    DOE R&D Accomplishments Database

    Cummings, J.; Cohen, S. A.; Hulse, R.; Post, D. E.; Redi, M. H.; Perkins, J.

    1990-07-01

    The MIST code has been used to model impurity radiation from the edge and core plasmas in ITER and CIT. A broad range of parameters have been varied, including Z{sub eff}, impurity species, impurity transport coefficients, and plasma temperature and density profiles, especially at the edge. For a set of these parameters representative of the baseline ITER ignition scenario, it is seen that impurity radiation, which is produced in roughly equal amounts by the edge and core regions, can make a major improvement in divertor operation without compromising core energy confinement. Scalings of impurity radiation with atomic number and machine size are also discussed.

  9. Iterative reconstruction of detector response of an Anger gamma camera.

    PubMed

    Morozov, A; Solovov, V; Alves, F; Domingos, V; Martins, R; Neves, F; Chepel, V

    2015-05-21

    Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the photomultiplier tube light-response functions. Here we describe an iterative method which allows one to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the method for medical gamma cameras is demonstrated using both simulated and experimental data. An implementation of the iterative reconstruction technique capable of operating in real time is presented. We show that this technique can also be used for monitoring photomultiplier gain variations. PMID:25951792

  10. United States Research and Development effort on ITER magnet tasks

    DOE PAGESBeta

    Martovetsky, Nicolai N.; Reierson, Wayne T.

    2011-01-22

    This study presents the status of research and development (R&D) magnet tasks that are being performed in support of the U.S. ITER Project Office (USIPO) commitment to provide a central solenoid assembly and toroidal field conductor for the ITER machine to be constructed in Cadarache, France. The following development tasks are presented: winding development, inlets and outlets development, internal and bus joints development and testing, insulation development and qualification, vacuum-pressure impregnation, bus supports, and intermodule structure and materials characterization.

  11. New progress of ITER-PF strand production in WST

    NASA Astrophysics Data System (ADS)

    Li, J. F.; Liu, W. T.; Yan, L. X.; H, J.; Gao, H. X.; Liu, J. W.; Du, S. J.; Liu, X. H.; Feng, Y.; Zhang, P. X.; Liu, S.; Li, H. W.; Niu, E. W.

    2014-05-01

    ITER Poloidal Field (PF) systems consist of 6 independent coils with different dimensions and require NbTi superconductor and copper strands. Western Superconducting Technologies Co.,Ltd.(WST) will supply PF2-5 NbTi strand for ITER, and over 14,000 km of NbTi strands have been produced in the past two years. Main performance of NbTi strands, including critical current, n value, wire diameter, Cu/non-Cu ratio, hysteresis loss and RRR are reported and analysed in this paper.

  12. Iterative methods for solving nonlinear problems of nuclear reactor criticality

    SciTech Connect

    Kuz'min, A. M.

    2012-12-15

    The paper presents iterative methods for calculating the neutron flux distribution in nonlinear problems of nuclear reactor criticality. Algorithms for solving equations for variations in the neutron flux are considered. Convergence of the iterative processes is studied for two nonlinear problems in which macroscopic interaction cross sections are functionals of the spatial neutron distribution. In the first problem, the neutron flux distribution depends on the water coolant density, and in the second one, it depends on the fuel temperature. Simple relationships connecting the vapor content and the temperature with the neutron flux are used.

  13. Iterative reconstruction of detector response of an Anger gamma camera

    NASA Astrophysics Data System (ADS)

    Morozov, A.; Solovov, V.; Alves, F.; Domingos, V.; Martins, R.; Neves, F.; Chepel, V.

    2015-05-01

    Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the photomultiplier tube light-response functions. Here we describe an iterative method which allows one to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the method for medical gamma cameras is demonstrated using both simulated and experimental data. An implementation of the iterative reconstruction technique capable of operating in real time is presented. We show that this technique can also be used for monitoring photomultiplier gain variations.

  14. A first characterization of the quench detection system for ITER

    SciTech Connect

    Marinucci, C.; Bottura, L. |; Pourrahimi, S.

    1995-03-01

    The purpose of this paper is to assess the expected response of conventional and non-conventional quench detection sensors proposed for the ITER coils, and to be tested in the QUELL experiment in SULTAN. The assessment is based on simulation of thermohydraulic transients in the ITER coils for various operating conditions, and a tentative definition of the transfer functions of each sensor concept. It is shown that, for the investigated conditions, the co-wound voltage taps are more accurate than hydraulic systems and conventional voltage balance methods. The additional complication associated with the insertion of taps in the conductor is well offset by the low sensitivity to external disturbances.

  15. Bragg x-ray survey spectrometer for ITER

    SciTech Connect

    Varshney, S. K.; Jakhar, S.; Barnsley, R.; O'Mullane, M. G.

    2012-10-15

    Several potential impurity ions in the ITER plasmas will lead to loss of confined energy through line and continuum emission. For real time monitoring of impurities, a seven channel Bragg x-ray spectrometer (XRCS survey) is considered. This paper presents design and analysis of the spectrometer, including x-ray tracing by the Shadow-XOP code, sensitivity calculations for reference H-mode plasma and neutronics assessment. The XRCS survey performance analysis shows that the ITER measurement requirements of impurity monitoring in 10 ms integration time at the minimum levels for low-Z to high-Z impurity ions can largely be met.

  16. Diagnostics of the ITER neutral beam test facility

    SciTech Connect

    Pasqualotto, R.; Serianni, G.; Agostini, M.; Brombin, M.; Dalla Palma, M.; Gazza, E.; Pomaro, N.; Rizzolo, A.; Spolaore, M.; Zaniol, B.; Sonato, P.; De Muri, M.; Croci, G.; Gorini, G.

    2012-02-15

    The ITER heating neutral beam (HNB) injector, based on negative ions accelerated at 1 MV, will be tested and optimized in the SPIDER source and MITICA full injector prototypes, using a set of diagnostics not available on the ITER HNB. The RF source, where the H{sup -}/D{sup -} production is enhanced by cesium evaporation, will be monitored with thermocouples, electrostatic probes, optical emission spectroscopy, cavity ring down, and laser absorption spectroscopy. The beam is analyzed by cooling water calorimetry, a short pulse instrumented calorimeter, beam emission spectroscopy, visible tomography, and neutron imaging. Design of the diagnostic systems is presented.

  17. Bragg x-ray survey spectrometer for ITER.

    PubMed

    Varshney, S K; Barnsley, R; O'Mullane, M G; Jakhar, S

    2012-10-01

    Several potential impurity ions in the ITER plasmas will lead to loss of confined energy through line and continuum emission. For real time monitoring of impurities, a seven channel Bragg x-ray spectrometer (XRCS survey) is considered. This paper presents design and analysis of the spectrometer, including x-ray tracing by the Shadow-XOP code, sensitivity calculations for reference H-mode plasma and neutronics assessment. The XRCS survey performance analysis shows that the ITER measurement requirements of impurity monitoring in 10 ms integration time at the minimum levels for low-Z to high-Z impurity ions can largely be met.

  18. Diagnostics of the ITER neutral beam test facility.

    PubMed

    Pasqualotto, R; Serianni, G; Sonato, P; Agostini, M; Brombin, M; Croci, G; Dalla Palma, M; De Muri, M; Gazza, E; Gorini, G; Pomaro, N; Rizzolo, A; Spolaore, M; Zaniol, B

    2012-02-01

    The ITER heating neutral beam (HNB) injector, based on negative ions accelerated at 1 MV, will be tested and optimized in the SPIDER source and MITICA full injector prototypes, using a set of diagnostics not available on the ITER HNB. The RF source, where the H(-)∕D(-) production is enhanced by cesium evaporation, will be monitored with thermocouples, electrostatic probes, optical emission spectroscopy, cavity ring down, and laser absorption spectroscopy. The beam is analyzed by cooling water calorimetry, a short pulse instrumented calorimeter, beam emission spectroscopy, visible tomography, and neutron imaging. Design of the diagnostic systems is presented.

  19. Power radiated from ITER and CIT by impurities

    SciTech Connect

    Cummings, J.; Cohen, S.A.; Hulse, R.; Post, D.E.; Redi, M.H.; Perkins, J.

    1990-07-01

    The MIST code has been used to model impurity radiation from the edge and core plasmas in ITER and CIT. A broad range of parameters have been varied, including Z{sub eff}, impurity species, impurity transport coefficients, and plasma temperature and density profiles, especially at the edge. For a set of these parameters representative of the baseline ITER ignition scenario, it is seen that impurity radiation, which is produced in roughly equal amounts by the edge and core regions, can make a major improvement in divertor operation without compromising core energy confinement. Scalings of impurity radiation with atomic number and machine size are also discussed. 22 refs., 16 figs.

  20. Weighting iterative Fourier transform algorithm of the kinoform synthesis.

    PubMed

    Kuzmenko, Alexander V

    2008-05-15

    Two object-dependent filters (an amplitude and a phase filter) are used in the object plane on the iterative calculation of a kinoform instead of a single (phase) filter as usual. The amplitude filter is a system of weight coefficients that vary in the process of iterations and control the amplitude of an input object. The advantages of the proposed method over other ones are confirmed by computer-based experiments. It is found that the method is most efficient for binary objects.

  1. An iterative multidisciplinary analysis for rotor blade shape determination

    NASA Technical Reports Server (NTRS)

    Mahajan, Aparajit J.; Stefko, George L.

    1993-01-01

    A CFD solver called ADPAC-APES is coupled with a NASTRAN structural analysis and a MARC thermal/heat transfer analysis to determine rotor blade shape. Nonlinear blade displacements due to centrifugal loads, aerodynamic pressures, and nonuniform temperature distribution are determined simultaneously. The effect of blade displacements on aerodynamic pressures and temperatures is then analyzed. These calculations are iterated till a steady state is reached across all the disciplines. This iterative procedure is applied to a ducted fan rotor blade and the manufactured shape is determined from a given operating shape. Effect of a part-span shroud on blade deflections is also analyzed.

  2. Raft River well stimulation experiments: geothermal reservoir well stimulation program

    SciTech Connect

    Not Available

    1980-08-01

    The Geothermal Reservoir Well Stimulation Program (GRWSP) performed two field experiments at the Raft River KGRA in 1979. Wells RRGP-4 and RRGP-5 were selected for the hydraulic fracture stimulation treatments. The well selection process, fracture treatment design, field execution, stimulation results, and pre- and post-job evaluations are presented.

  3. Human Tissue Stimulator

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Neurodyne Corporation Human Tissue Stimulator (HTS) is a totally implantable system used for treatment of chronic pain and involuntary motion disorders by electrical stimulation. It was developed by Pacesetter Systems, Inc. in cooperation with the Applied Physics Laboratory. HTS incorporates a nickel cadmium battery, telemetry and command systems technologies of the same type as those used in NASA's Small Astronomy Satellite-3 in microminiature proportions so that the implantable element is the size of a deck of cards. The stimulator includes a rechargeable battery, an antenna and electronics to receive and process commands and to report on its own condition via telemetry, a wireless process wherein instrument data is converted to electrical signals and sent to a receiver where signals are presented as usable information. The HTS is targeted to nerve centers or to particular areas of the brain to provide relief from intractable pain or arrest involuntary motion. The nickel cadmium battery can be recharged through the skin. The first two HTS units were implanted last year and have been successful. Extensive testing is required before HTS can be made available for general use.

  4. Rapid computation of chemical equilibrium composition - An application to hydrocarbon combustion

    NASA Technical Reports Server (NTRS)

    Erickson, W. D.; Prabhu, R. K.

    1986-01-01

    A scheme for rapidly computing the chemical equilibrium composition of hydrocarbon combustion products is derived. A set of ten governing equations is reduced to a single equation that is solved by the Newton iteration method. Computation speeds are approximately 80 times faster than the often used free-energy minimization method. The general approach also has application to many other chemical systems.

  5. Rapid, Enhanced IV Characterization of Multi-Junction PV Devices under One Sun at NREL

    SciTech Connect

    Moriarty, Tom; France, Ryan; Steiner, Myles

    2015-06-14

    Multi-junction technology is rapidly advancing, which puts increasing demands on IV characterization resources. We report on a tool and procedure for fast turn-around of IV data under the reference conditions, but also under controlled variations from the reference conditions. This enhanced data set can improve further iterations of device optimization.

  6. Rapid, Enhanced IV Characterization of Multi-Junction PV Devices under One Sun at NREL: Preprint

    SciTech Connect

    Moriarty, Tom; France, Ryan; Steiner, Myles

    2015-09-15

    Multi-junction technology is rapidly advancing, which puts increasing demands on IV characterization resources. We report on a tool and procedure for fast turn-around of IV data under the reference conditions, but also under controlled variations from the reference conditions. This enhanced data set can improve further iterations of device optimization.

  7. Improvements In Optically Stimulated Electron Emission

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Welch, Christopher S.; Joe, Edmond J.; Hefner, Bill B., Jr.

    1994-01-01

    Optically stimulated electron emission (OSEE) used in inspection for contamination of critical bonding surfaces in solid rocket motors of Space Shuttle prior to formation of adhesive bonds on surfaces during manufacture and refurbishment. Fundamental OSEE inspection technique described in "Surface-Contamination Inspection Tool for Field Use" (MFS-25581) and "Detecting Contamination With Photoelectron Emission" (MFS-25619). OSEE measurement head easily portable, and measurement operation convenient and rapid, making it useful inspection technique in industrial environment. Reveals contamination in many situations in which other techniques do not work.

  8. Rapid virtual stenting for intracranial aneurysms

    NASA Astrophysics Data System (ADS)

    Zhao, Liang; Chen, Danyang; Chen, Zihe; Wang, Xiangyu; Paliwal, Nikhil; Xiang, Jianping; Meng, Hui; Corso, Jason J.; Xu, Jinhui

    2016-03-01

    The rupture of Intracranial Aneurysms is the most severe form of stroke with high rates of mortality and disability. One of its primary treatments is to use stent or Flow Diverter to divert the blood flow away from the IA in a minimal invasive manner. To optimize such treatments, it is desirable to provide an automatic tool for virtual stenting before its actual implantation. In this paper, we propose a novel method, called ball-sweeping, for rapid virtual stenting. Our method sweeps a maximum inscribed sphere through the aneurysmal region of the vessel and directly generates a stent surface touching the vessel wall without needing to iteratively grow a deformable stent surface. Our resulting stent mesh has guaranteed smoothness and variable pore density to achieve an enhanced occlusion performance. Comparing to existing methods, our technique is computationally much more efficient.

  9. Rapid Virtual Stenting for Intracranial Aneurysms

    PubMed Central

    Zhao, Liang; Chen, Danyang; Chen, Zihe; Wang, Xiangyu; Paliwal, Nikhil; Xiang, Jianping; Meng, Hui; Corso, Jason J.; Xu, Jinhui

    2016-01-01

    The rupture of Intracranial Aneurysms is the most severe form of stroke with high rates of mortality and disability. One of its primary treatments is to use stent or Flow Diverter to divert the blood flow away from the IA in a minimal invasive manner. To optimize such treatments, it is desirable to provide an automatic tool for virtual stenting before its actual implantation. In this paper, we propose a novel method, called ball-sweeping, for rapid virtual stenting. Our method sweeps a maximum inscribed sphere through the aneurysmal region of the vessel and directly generates a stent surface touching the vessel wall without needing to iteratively grow a deformable stent surface. Our resulting stent mesh has guaranteed smoothness and variable pore density to achieve an enhanced occlusion performance. Comparing to existing methods, our technique is computationally much more efficient. PMID:27346910

  10. Fast multigrid-based computation of the induced electric field for transcranial magnetic stimulation

    NASA Astrophysics Data System (ADS)

    Laakso, Ilkka; Hirata, Akimasa

    2012-12-01

    In transcranial magnetic stimulation (TMS), the distribution of the induced electric field, and the affected brain areas, depends on the position of the stimulation coil and the individual geometry of the head and brain. The distribution of the induced electric field in realistic anatomies can be modelled using computational methods. However, existing computational methods for accurately determining the induced electric field in realistic anatomical models have suffered from long computation times, typically in the range of tens of minutes or longer. This paper presents a matrix-free implementation of the finite-element method with a geometric multigrid method that can potentially reduce the computation time to several seconds or less even when using an ordinary computer. The performance of the method is studied by computing the induced electric field in two anatomically realistic models. An idealized two-loop coil is used as the stimulating coil. Multiple computational grid resolutions ranging from 2 to 0.25 mm are used. The results show that, for macroscopic modelling of the electric field in an anatomically realistic model, computational grid resolutions of 1 mm or 2 mm appear to provide good numerical accuracy compared to higher resolutions. The multigrid iteration typically converges in less than ten iterations independent of the grid resolution. Even without parallelization, each iteration takes about 1.0 s or 0.1 s for the 1 and 2 mm resolutions, respectively. This suggests that calculating the electric field with sufficient accuracy in real time is feasible.

  11. SULTAN measurement and qualification: ITER-US-LLNL-NMARTOVETSKY- 092008

    SciTech Connect

    Martovetsky, N N

    2006-09-21

    Measuring the characteristics of full scale ITER CICC at SULTAN is the critical qualification test. If volt-ampere characteristic (VAC) or volt-temperature characteristic (VTC) are distorted, the criterion of 10 uV/m may not be a valid criterion to judge the conductor performance. Only measurements with a clear absence or low signals from the current distribution should be considered as quantitatively representative, although in some obvious circumstances one can judge if a conductor will meet or fail ITER requirements. SULTAN full scale ITER CICC testing should be done with all measures taken to ensure uniform current redistribution. A full removal of Cr plating in the joint area and complete solder filling of the joints (with provision of the central channel for helium flow) should be mandatory for DC qualification samples for ITER. Also, T and I should be increased slowly that an equilibrium could be established for accurate measurement of Tcs, Ic and N. It is also desirable to go up in down in current and/or temperature (within stable range) to make sure that the equilibrium is reached.

  12. A Simple Iterative Solution of Nonlinear Algebraic Systems

    NASA Astrophysics Data System (ADS)

    Gousidou, Maria; Koutitas, Christopher

    2009-09-01

    A simple, robust, easily programmable and efficient method for the iterative solution of nonlinear algebraic systems, commonly appearing in nonlinear mechanics, based on Newton-Raphson method (without repeatedly solving linear algebraic systems), is proposed, synoptically described and experimentally investigated. Fast convergence and easy programming are its main qualifications.

  13. An Iterative Reweighted Method for Tucker Decomposition of Incomplete Tensors

    NASA Astrophysics Data System (ADS)

    Yang, Linxiao; Fang, Jun; Li, Hongbin; Zeng, Bing

    2016-09-01

    We consider the problem of low-rank decomposition of incomplete multiway tensors. Since many real-world data lie on an intrinsically low dimensional subspace, tensor low-rank decomposition with missing entries has applications in many data analysis problems such as recommender systems and image inpainting. In this paper, we focus on Tucker decomposition which represents an Nth-order tensor in terms of N factor matrices and a core tensor via multilinear operations. To exploit the underlying multilinear low-rank structure in high-dimensional datasets, we propose a group-based log-sum penalty functional to place structural sparsity over the core tensor, which leads to a compact representation with smallest core tensor. The method for Tucker decomposition is developed by iteratively minimizing a surrogate function that majorizes the original objective function, which results in an iterative reweighted process. In addition, to reduce the computational complexity, an over-relaxed monotone fast iterative shrinkage-thresholding technique is adapted and embedded in the iterative reweighted process. The proposed method is able to determine the model complexity (i.e. multilinear rank) in an automatic way. Simulation results show that the proposed algorithm offers competitive performance compared with other existing algorithms.

  14. From Intent to Action: An Iterative Engineering Process

    ERIC Educational Resources Information Center

    Mouton, Patrice; Rodet, Jacques; Vacaresse, Sylvain

    2015-01-01

    Quite by chance, and over the course of a few haphazard meetings, a Master's degree in "E-learning Design" gradually developed in a Faculty of Economics. Its original and evolving design was the result of an iterative process carried out, not by a single Instructional Designer (ID), but by a full ID team. Over the last 10 years it has…

  15. Evaluation of neutron spectrometer techniques for ITER using synthetic data

    NASA Astrophysics Data System (ADS)

    Andersson Sundén, E.; Ballabio, L.; Cecconello, M.; Conroy, S.; Ericsson, G.; Johnson, M. Gatu; Gorini, G.; Hellesen, C.; Ognissanto, F.; Ronchi, E.; Sjöstrand, H.; Tardocchi, M.; Weiszflog, M.

    2013-02-01

    A neutron spectrometer at ITER is expected to provide estimates of plasma parameters such as ion temperature, Ti, fuel ion ratio, nt/nd, and Qthermal/Qtot, with 10-20% precision at a time resolution, Δt, of at least 100 ms. The present paper describes a method for evaluating different neutron spectroscopy techniques based on their instrumental response functions and synthetic measurement data. We include five different neutron spectrometric techniques with realistic response functions, based on simulations and measurements where available. The techniques are magnetic proton recoil, thin-foil proton recoil, gamma discriminating organic scintillator, diamond and time-of-flight. The reference position and line of sight of a high resolution neutron spectrometer on ITER are used in the study. ITER plasma conditions are simulated for realistic operating scenarios. The ITER conditions evaluated are beam and radio frequency heated and thermal deuterium-tritium plasmas. Results are given for each technique in terms of the estimated time resolution at which the parameter determination can be made within the required precision (here 10% for Ti and the relative intensities of NB and RF emission components). It is shown that under the assumptions made, the thin-foil techniques out-perform the other spectroscopy techniques in practically all measurement situations. For thermal conditions, the range of achieved Δt in the determination of Ti varies in time scales from ms (for the magnetic and thin-foil proton recoil) to s (for gamma discriminating organic scintillator).

  16. Iterated unscented Kalman filter for phase unwrapping of interferometric fringes.

    PubMed

    Xie, Xianming

    2016-08-22

    A fresh phase unwrapping algorithm based on iterated unscented Kalman filter is proposed to estimate unambiguous unwrapped phase of interferometric fringes. This method is the result of combining an iterated unscented Kalman filter with a robust phase gradient estimator based on amended matrix pencil model, and an efficient quality-guided strategy based on heap sort. The iterated unscented Kalman filter that is one of the most robust methods under the Bayesian theorem frame in non-linear signal processing so far, is applied to perform simultaneously noise suppression and phase unwrapping of interferometric fringes for the first time, which can simplify the complexity and the difficulty of pre-filtering procedure followed by phase unwrapping procedure, and even can remove the pre-filtering procedure. The robust phase gradient estimator is used to efficiently and accurately obtain phase gradient information from interferometric fringes, which is needed for the iterated unscented Kalman filtering phase unwrapping model. The efficient quality-guided strategy is able to ensure that the proposed method fast unwraps wrapped pixels along the path from the high-quality area to the low-quality area of wrapped phase images, which can greatly improve the efficiency of phase unwrapping. Results obtained from synthetic data and real data show that the proposed method can obtain better solutions with an acceptable time consumption, with respect to some of the most used algorithms. PMID:27557170

  17. On pre-image iterations for speech enhancement.

    PubMed

    Leitner, Christina; Pernkopf, Franz

    2015-01-01

    In this paper, we apply kernel PCA for speech enhancement and derive pre-image iterations for speech enhancement. Both methods make use of a Gaussian kernel. The kernel variance serves as tuning parameter that has to be adapted according to the SNR and the desired degree of de-noising. We develop a method to derive a suitable value for the kernel variance from a noise estimate to adapt pre-image iterations to arbitrary SNRs. In experiments, we compare the performance of kernel PCA and pre-image iterations in terms of objective speech quality measures and automatic speech recognition. The speech data is corrupted by white and colored noise at 0, 5, 10, and 15 dB SNR. As a benchmark, we provide results of the generalized subspace method, of spectral subtraction, and of the minimum mean-square error log-spectral amplitude estimator. In terms of the scores of the PEASS (Perceptual Evaluation Methods for Audio Source Separation) toolbox, the proposed methods achieve a similar performance as the reference methods. The speech recognition experiments show that the utterances processed by pre-image iterations achieve a consistently better word recognition accuracy than the unprocessed noisy utterances and than the utterances processed by the generalized subspace method. PMID:26085973

  18. Experimental Vertical Stability Studies for ITER Performance and Design Guidance

    SciTech Connect

    Humphreys, D A; Casper, T A; Eidietis, N; Ferrera, M; Gates, D A; Hutchinson, I H; Jackson, G L; Kolemen, E; Leuer, J A; Lister, J; LoDestro, L L; Meyer, W H; Pearlstein, L D; Sartori, F; Walker, M L; Welander, A S; Wolfe, S M

    2008-10-13

    Operating experimental devices have provided key inputs to the design process for ITER axisymmetric control. In particular, experiments have quantified controllability and robustness requirements in the presence of realistic noise and disturbance environments, which are difficult or impossible to characterize with modeling and simulation alone. This kind of information is particularly critical for ITER vertical control, which poses some of the highest demands on poloidal field system performance, since the consequences of loss of vertical control can be very severe. The present work describes results of multi-machine studies performed under a joint ITPA experiment on fundamental vertical control performance and controllability limits. We present experimental results from Alcator C-Mod, DIII-D, NSTX, TCV, and JET, along with analysis of these data to provide vertical control performance guidance to ITER. Useful metrics to quantify this control performance include the stability margin and maximum controllable vertical displacement. Theoretical analysis of the maximum controllable vertical displacement suggests effective approaches to improving performance in terms of this metric, with implications for ITER design modifications. Typical levels of noise in the vertical position measurement which can challenge the vertical control loop are assessed and analyzed.

  19. Solid deposition in the ITER cryogenic viscous compressor

    NASA Astrophysics Data System (ADS)

    Zhang, Dongsheng; Miller, Franklin K.; Pfotenhauer, John M.

    2016-09-01

    A transient model for the ITER cryogenic viscous compressor (CVC) is presented. The CVC is designed to separate hydrogen isotopes from helium in the gas-mixture exhaust from the ITER torus. During their residence in the CVC, hydrogen isotopes are captured along the pump wall while helium flows through. The CVC thereby provides the first stage of helium compression. The transient model characterizes the transport phenomena (species, momentum, and energy) that occur in the CVC. The numerical results are compared with experimental data from a scaled down test of the ITER CVC using pure hydrogen. Although the model has been developed for a hydrogen-helium mixture, it is simplified here in order to compare with the experimental data. The transient model, along with other numerical models we have developed, provide guidance for the design and optimization of the ITER CVC. The model can also be a useful tool or a reference for similar analyses, such as those for cryogenic carbon capture and air ingress in vacuum isolated cryogenic vessels.

  20. Active spectroscopic measurements using the ITER diagnostic system

    SciTech Connect

    Thomas, D. M.; Counsell, G.; Johnson, D.; Vasu, P.; Zvonkov, A.

    2010-10-15

    Active (beam-based) spectroscopic measurements are intended to provide a number of crucial parameters for the ITER device being built in Cadarache, France. These measurements include the determination of impurity ion temperatures, absolute densities, and velocity profiles, as well as the determination of the plasma current density profile. Because ITER will be the first experiment to study long timescale ({approx}1 h) fusion burn plasmas, of particular interest is the ability to study the profile of the thermalized helium ash resulting from the slowing down and confinement of the fusion alphas. These measurements will utilize both the 1 MeV heating neutral beams and a dedicated 100 keV hydrogen diagnostic neutral beam. A number of separate instruments are being designed and built by several of the ITER partners to meet the different spectroscopic measurement needs and to provide the maximum physics information. In this paper, we describe the planned measurements, the intended diagnostic ensemble, and we will discuss specific physics and engineering challenges for these measurements in ITER.

  1. Using Minimum-Surface Bodies for Iteration Space Partitioning

    NASA Technical Reports Server (NTRS)

    Frumlin, Michael; VanderWijngaart, Rob F.; Biegel, Bryan (Technical Monitor)

    2001-01-01

    A number of known techniques for improving cache performance in scientific computations involve the reordering of the iteration space. Some of these reorderings can be considered as coverings of the iteration space with the sets having good surface-to-volume ratio. Use of such sets reduces the number of cache misses in computations of local operators having the iteration space as a domain. We study coverings of iteration spaces represented by structured and unstructured grids. For structured grids we introduce a covering based on successive minima tiles of the interference lattice of the grid. We show that the covering has good surface-to-volume ratio and present a computer experiment showing actual reduction of the cache misses achieved by using these tiles. For unstructured grids no cache efficient covering can be guaranteed. We present a triangulation of a 3-dimensional cube such that any local operator on the corresponding grid has significantly larger number of cache misses than a similar operator on a structured grid.

  2. Concept And Development Of Instruments For ITER Thermography

    SciTech Connect

    Reichle, R.; Balorin, C.; Carpentier, S.; Corre, Y.; Davi, M.; Delchambre, E.; Desgrange, C.; Escourbiac, F.; Fougerolle, S.; Gardarein, J. L.; Gauthier, E.; Guilhem, D.; Jouve, M.; Loarer, Th.; Martins, J. P.; Patterlini, J. C.; Pocheau, C.; Roche, H.; Salasca, S.; Travere, J. M.

    2008-03-12

    We give here a short overview of the status of the development for ITER thermography as performed by the CEA-Cadarache and some of its collaboration partners. The topics that have been included in this synthesis are the status of the optical design, the role of multi-wavelength mesurements, multicolour pyroreflectometry, photothermal methods, and reflection simulations and measurements.

  3. Layout compliance for triple patterning lithography: an iterative approach

    NASA Astrophysics Data System (ADS)

    Yu, Bei; Garreton, Gilda; Pan, David Z.

    2014-10-01

    As the semiconductor process further scales down, the industry encounters many lithography-related issues. In the 14nm logic node and beyond, triple patterning lithography (TPL) is one of the most promising techniques for Metal1 layer and possibly Via0 layer. As one of the most challenging problems in TPL, recently layout decomposition efforts have received more attention from both industry and academia. Ideally the decomposer should point out locations in the layout that are not triple patterning decomposable and therefore manual intervention by designers is required. A traditional decomposition flow would be an iterative process, where each iteration consists of an automatic layout decomposition step and manual layout modification task. However, due to the NP-hardness of triple patterning layout decomposition, automatic full chip level layout decomposition requires long computational time and therefore design closure issues continue to linger around in the traditional flow. Challenged by this issue, we present a novel incremental layout decomposition framework to facilitate accelerated iterative decomposition. In the first iteration, our decomposer not only points out all conflicts, but also provides the suggestions to fix them. After the layout modification, instead of solving the full chip problem from scratch, our decomposer can provide a quick solution for a selected portion of layout. We believe this framework is efficient, in terms of performance and designer friendly.

  4. On a Cubically Convergent Iterative Method for Matrix Sign

    PubMed Central

    Sharifi, M.; Karimi Vanani, S.; Khaksar Haghani, F.; Arab, M.; Shateyi, S.

    2015-01-01

    We propose an iterative method for finding matrix sign function. It is shown that the scheme has global behavior with cubical rate of convergence. Examples are included to show the applicability and efficiency of the proposed scheme and its reciprocal. PMID:25954769

  5. Active spectroscopic measurements using the ITER diagnostic system.

    PubMed

    Thomas, D M; Counsell, G; Johnson, D; Vasu, P; Zvonkov, A

    2010-10-01

    Active (beam-based) spectroscopic measurements are intended to provide a number of crucial parameters for the ITER device being built in Cadarache, France. These measurements include the determination of impurity ion temperatures, absolute densities, and velocity profiles, as well as the determination of the plasma current density profile. Because ITER will be the first experiment to study long timescale (∼1 h) fusion burn plasmas, of particular interest is the ability to study the profile of the thermalized helium ash resulting from the slowing down and confinement of the fusion alphas. These measurements will utilize both the 1 MeV heating neutral beams and a dedicated 100 keV hydrogen diagnostic neutral beam. A number of separate instruments are being designed and built by several of the ITER partners to meet the different spectroscopic measurement needs and to provide the maximum physics information. In this paper, we describe the planned measurements, the intended diagnostic ensemble, and we will discuss specific physics and engineering challenges for these measurements in ITER.

  6. Iterated unscented Kalman filter for phase unwrapping of interferometric fringes.

    PubMed

    Xie, Xianming

    2016-08-22

    A fresh phase unwrapping algorithm based on iterated unscented Kalman filter is proposed to estimate unambiguous unwrapped phase of interferometric fringes. This method is the result of combining an iterated unscented Kalman filter with a robust phase gradient estimator based on amended matrix pencil model, and an efficient quality-guided strategy based on heap sort. The iterated unscented Kalman filter that is one of the most robust methods under the Bayesian theorem frame in non-linear signal processing so far, is applied to perform simultaneously noise suppression and phase unwrapping of interferometric fringes for the first time, which can simplify the complexity and the difficulty of pre-filtering procedure followed by phase unwrapping procedure, and even can remove the pre-filtering procedure. The robust phase gradient estimator is used to efficiently and accurately obtain phase gradient information from interferometric fringes, which is needed for the iterated unscented Kalman filtering phase unwrapping model. The efficient quality-guided strategy is able to ensure that the proposed method fast unwraps wrapped pixels along the path from the high-quality area to the low-quality area of wrapped phase images, which can greatly improve the efficiency of phase unwrapping. Results obtained from synthetic data and real data show that the proposed method can obtain better solutions with an acceptable time consumption, with respect to some of the most used algorithms.

  7. Speedup of linear stationary iteration processes in multiprocessor computers. I

    SciTech Connect

    Romm, Ya.E.

    1982-01-01

    The author considers two forms of stationary iteration process. Conditions are discussed under which the simpler process is slower than the other one on a multiprocessing computer, for the same method error. Estimates of the number of processors and the computation time are compared. Results are applied to Jacobi's method of solving systems of linear algebraic equations. 27 references.

  8. Adaptively Tuned Iterative Low Dose CT Image Denoising.

    PubMed

    Hashemi, SayedMasoud; Paul, Narinder S; Beheshti, Soosan; Cobbold, Richard S C

    2015-01-01

    Improving image quality is a critical objective in low dose computed tomography (CT) imaging and is the primary focus of CT image denoising. State-of-the-art CT denoising algorithms are mainly based on iterative minimization of an objective function, in which the performance is controlled by regularization parameters. To achieve the best results, these should be chosen carefully. However, the parameter selection is typically performed in an ad hoc manner, which can cause the algorithms to converge slowly or become trapped in a local minimum. To overcome these issues a noise confidence region evaluation (NCRE) method is used, which evaluates the denoising residuals iteratively and compares their statistics with those produced by additive noise. It then updates the parameters at the end of each iteration to achieve a better match to the noise statistics. By combining NCRE with the fundamentals of block matching and 3D filtering (BM3D) approach, a new iterative CT image denoising method is proposed. It is shown that this new denoising method improves the BM3D performance in terms of both the mean square error and a structural similarity index. Moreover, simulations and patient results show that this method preserves the clinically important details of low dose CT images together with a substantial noise reduction. PMID:26089972

  9. Linear multifrequency-grey acceleration recast for preconditioned Krylov iterations

    SciTech Connect

    Morel, Jim E. Brian Yang, T.-Y.; Warsa, James S.

    2007-11-10

    The linear multifrequency-grey acceleration (LMFGA) technique is used to accelerate the iterative convergence of multigroup thermal radiation diffusion calculations in high energy density simulations. Although it is effective and efficient in one-dimensional calculations, the LMFGA method has recently been observed to significantly degrade under certain conditions in multidimensional calculations with large discontinuities in material properties. To address this deficiency, we recast the LMFGA method in terms of a preconditioned system that is solved with a Krylov method (LMFGK). Results are presented demonstrating that the new LMFGK method always requires fewer iterations than the original LMFGA method. The reduction in iteration count increases with both the size of the time step and the inhomogeneity of the problem. However, for reasons later explained, the LMFGK method can cost more per iteration than the LMFGA method, resulting in lower but comparable efficiency in problems with small time steps and weak inhomogeneities. In problems with large time steps and strong inhomogeneities, the LMFGK method is significantly more efficient than the LMFGA method.

  10. Adaptively Tuned Iterative Low Dose CT Image Denoising

    PubMed Central

    Hashemi, SayedMasoud; Paul, Narinder S.; Beheshti, Soosan; Cobbold, Richard S. C.

    2015-01-01

    Improving image quality is a critical objective in low dose computed tomography (CT) imaging and is the primary focus of CT image denoising. State-of-the-art CT denoising algorithms are mainly based on iterative minimization of an objective function, in which the performance is controlled by regularization parameters. To achieve the best results, these should be chosen carefully. However, the parameter selection is typically performed in an ad hoc manner, which can cause the algorithms to converge slowly or become trapped in a local minimum. To overcome these issues a noise confidence region evaluation (NCRE) method is used, which evaluates the denoising residuals iteratively and compares their statistics with those produced by additive noise. It then updates the parameters at the end of each iteration to achieve a better match to the noise statistics. By combining NCRE with the fundamentals of block matching and 3D filtering (BM3D) approach, a new iterative CT image denoising method is proposed. It is shown that this new denoising method improves the BM3D performance in terms of both the mean square error and a structural similarity index. Moreover, simulations and patient results show that this method preserves the clinically important details of low dose CT images together with a substantial noise reduction. PMID:26089972

  11. Stimulants and the lung : review of literature.

    PubMed

    Tseng, Will; Sutter, Mark E; Albertson, Timothy E

    2014-02-01

    Illicit stimulants, such as cocaine, amphetamine, and their derivatives (e.g., "ecstasy"), continue to exact heavy toll on health care in both developed and developing countries. The US Department of Health and Human Service reported over one million illicit drug-related emergency department visits in 2010, which was higher than any of the six previous years. Both inhaled and intravenous forms of these substances of abuse can result in a variety of acute and chronic injuries to practically every part of the respiratory tract, leading potentially to permanent morbidities as well as fatal consequences--including but not limited to nasal septum perforation, pulmonary hypertension, pneumothorax, pneumomediastinum, interstitial lung disease, alveolar hemorrhage, reactive airway disease, pulmonary edema, pulmonary granulomatosis, infections, foreign body aspiration, infections, bronchoconstriction, and thermal injuries. Stimulants are all rapidly absorbed substances that can also significantly alter the patient's systemic acid-base balance and central nervous system, thereby leading to further respiratory compromise. Mounting evidence in the past decade has demonstrated that adulterants coinhaled with these substances (e.g., levamisole) and the metabolites of these substances (e.g., cocaethylene) are associated with specific forms of systemic and respiratory complications as well. Recent studies have also demonstrated the effects of stimulants on autoimmune-mediated injuries of the respiratory tract, such as cocaine-induced midline destructive lesions. A persistent challenge to studies involving stimulant-associated respiratory toxidromes is the high prevalence of concomitant usage of various substances by drug abusers, including tobacco smoking. Now more than ever, health care providers must be familiar with the multitude of respiratory toxidromes as well as the diverse pathophysiology related to commonly abused stimulants to provide timely diagnosis and effective

  12. Stimulated parametric emission microscopy

    NASA Astrophysics Data System (ADS)

    Isobe, Keisuke; Kataoka, Shogo; Murase, Rena; Watanabe, Wataru; Higashi, Tsunehito; Kawakami, Shigeki; Matsunaga, Sachihiro; Fukui, Kiichi; Itoh, Kazuyoshi

    2006-01-01

    We propose a novel microscopy technique based on the four-wave mixing (FWM) process that is enhanced by two-photon electronic resonance induced by a pump pulse along with stimulated emission induced by a dump pulse. A Ti:sapphire laser and an optical parametric oscillator are used as light sources for the pump and dump pulses, respectively. We demonstrate that our proposed FWM technique can be used to obtain a one-dimensional image of ethanol-thinned Coumarin 120 solution sandwiched between a hole-slide glass and a cover slip, and a two-dimensional image of a leaf of Camellia sinensis.

  13. An iterative and regenerative method for DNA sequencing.

    PubMed

    Jones, D H

    1997-05-01

    This paper presents, to our knowledge, the first iterative DNA sequencing method that regenerates the product of interest during each iterative cycle, allowing it to overcome the critical obstacles that impede alternative iterative approaches to DNA sequencing: loss of product and the accumulation of background signal due to incomplete reactions. It can sequence numerous double-stranded (ds) DNA segments in parallel without gel resolution of DNA fragments and can sequence DNA that is almost entirely double-stranded, preventing the secondary structures that impede sequencing by hybridization. This method uses ligation of an adaptor containing the recognition domain for a class-IIS restriction endonuclease and digestion with a class-IIS restriction endonuclease that recognizes the adaptor's recognition domain. This generates a set of DNA templates that are each composed of a short overhang positioned at a fixed interval with respect to one end of the original dsDNA fragment. Adaptor ligation also appends a unique sequence during each iterative cycle, so that the polymerase chain reaction can be used to regenerate the desired template-precursor before class-IIS restriction endonuclease digestion. Following class-IIS restriction endonuclease digestion, sequencing of a nucleotide in each overhang occurs by template-directed ligation during adaptor ligation or through a separate template-directed polymerization step with labeled ddNTPs. DNA sequencing occurs in strides determined by the number of nucleotides separating the recognition and cleavage domains for the class-IIS restriction endonuclease encoded in the ligated adaptor, maximizing the span of DNA sequenced for a given number of iterative cycles. This method allows the concurrent sequencing of numerous dsDNA segments in a microplate format, and in the future it can be adapted to biochip format. PMID:9149879

  14. Dorsal column stimulator applications

    PubMed Central

    Yampolsky, Claudio; Hem, Santiago; Bendersky, Damián

    2012-01-01

    Background: Spinal cord stimulation (SCS) has been used to treat neuropathic pain since 1967. Following that, technological progress, among other advances, helped SCS become an effective tool to reduce pain. Methods: This article is a non-systematic review of the mechanism of action, indications, results, programming parameters, complications, and cost-effectiveness of SCS. Results: In spite of the existence of several studies that try to prove the mechanism of action of SCS, it still remains unknown. The mechanism of action of SCS would be based on the antidromic activation of the dorsal column fibers, which activate the inhibitory interneurons within the dorsal horn. At present, the indications of SCS are being revised constantly, while new applications are being proposed and researched worldwide. Failed back surgery syndrome (FBSS) is the most common indication for SCS, whereas, the complex regional pain syndrome (CRPS) is the second one. Also, this technique is useful in patients with refractory angina and critical limb ischemia, in whom surgical or endovascular treatment cannot be performed. Further indications may be phantom limb pain, chronic intractable pain located in the head, face, neck, or upper extremities, spinal lumbar stenosis in patients who are not surgical candidates, and others. Conclusion: Spinal cord stimulation is a useful tool for neuromodulation, if an accurate patient selection is carried out prior, which should include a trial period. Undoubtedly, this proper selection and a better knowledge of its underlying mechanisms of action, will allow this cutting edge technique to be more acceptable among pain physicians. PMID:23230533

  15. Central nervous system stimulants.

    PubMed

    George, A J

    2000-03-01

    Three major types of CNS stimulant are currently abused in sport: amphetamine, cocaine and caffeine. Each drug type has its own characteristic mechanism of action on CNS neurones and their associated receptors and nerve terminals. Amphetamine is widely abused in sports requiring intense anaerobic exercise where it prolongs the tolerance to anaerobic metabolism. It is addictive, and chronic abuse causes marked behavioural change and sometimes psychosis. Major sports abusing amphetamine are cycling, American football, ice-hockey and baseball. Cocaine increases tolerance to intense exercise, yet most of its chronic effects on energy metabolism are negative. Its greatest effects seem to be as a central stimulant and the enhancement of short-term anaerobic exercise. It is highly addictive and can cause cerebral and cardiovascular fatalities. Caffeine enhances fatty acid metabolism leading to glucose conservation, which appears to benefit long-distance endurance events such as skiing. Caffeine is also addictive, and chronic abuse can lead to cardiac damage. Social abuse of each of the three drugs is often difficult to distinguish from their abuse in sport.

  16. U.S ITER : electromagnetic analysis of transient forces due to disrupted plasma currents on the ITER shield modules.

    SciTech Connect

    Kotulski, Joseph Daniel; Coats, Rebecca Sue; Pasik, Michael Francis

    2007-06-01

    This paper describes the electromagnetic analysis that has been completed using the OPERA-3d product to characterize the forces on the ITER shield modules as part of the conceptual design. These forces exist due to the interaction of the eddy currents induced in the shield modules and the large magnetic fields present in the tokamak.

  17. THE EFFECTS OF CHRONIC IMMUNE STIMULATION ON MUSCLE GROWTH IN RAINBOW TROUT.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Successful production of aquaculture species depends on efficient growth with low susceptibility to disease. Therefore, selection programs have focused on rapid growth combined with disease resistance. However, chronic immune stimulation diminishes muscle growth (a syndrome referred to as cachexia),...

  18. Risk mitigation for ITER by a prolonged and joint international operation of JET

    NASA Astrophysics Data System (ADS)

    Donne, Antonius J.; Cowley, Steve; Jones, Timothy; Litaudon, Xavier; JET Team; CCFE Team

    2015-11-01

    Prolonged operation of the Joint European Torus (JET) in a set-up involving all ITER partners will be beneficial for ITER. Experiments at JET with its ITER-like wall and using a D-T plasma mixture will help to mitigate risks in the ITER research plan. Training of the ITER operators, technicians and engineers at JET will save valuable time when ITER comes into operation. Moreover, the way in which the future ITER experiments will be organized can already be experienced at JET, by imposing a similar organisational structure. This paper will present arguments in favour of an extension of JET and additionally briefly discuss a number of enhancements that will make experiments on JET even more relevant for ITER.

  19. Iterative-Transform Phase Retrieval Using Adaptive Diversity

    NASA Technical Reports Server (NTRS)

    Dean, Bruce H.

    2007-01-01

    A phase-diverse iterative-transform phase-retrieval algorithm enables high spatial-frequency, high-dynamic-range, image-based wavefront sensing. [The terms phase-diverse, phase retrieval, image-based, and wavefront sensing are defined in the first of the two immediately preceding articles, Broadband Phase Retrieval for Image-Based Wavefront Sensing (GSC-14899-1).] As described below, no prior phase-retrieval algorithm has offered both high dynamic range and the capability to recover high spatial-frequency components. Each of the previously developed image-based phase-retrieval techniques can be classified into one of two categories: iterative transform or parametric. Among the modifications of the original iterative-transform approach has been the introduction of a defocus diversity function (also defined in the cited companion article). Modifications of the original parametric approach have included minimizing alternative objective functions as well as implementing a variety of nonlinear optimization methods. The iterative-transform approach offers the advantage of ability to recover low, middle, and high spatial frequencies, but has disadvantage of having a limited dynamic range to one wavelength or less. In contrast, parametric phase retrieval offers the advantage of high dynamic range, but is poorly suited for recovering higher spatial frequency aberrations. The present phase-diverse iterative transform phase-retrieval algorithm offers both the high-spatial-frequency capability of the iterative-transform approach and the high dynamic range of parametric phase-recovery techniques. In implementation, this is a focus-diverse iterative-transform phaseretrieval algorithm that incorporates an adaptive diversity function, which makes it possible to avoid phase unwrapping while preserving high-spatial-frequency recovery. The algorithm includes an inner and an outer loop (see figure). An initial estimate of phase is used to start the algorithm on the inner loop, wherein

  20. A linearized current stimulator for deep brain stimulation.

    PubMed

    Shen, Ding-Lan; Chu, Yu-Jung

    2010-01-01

    This paper develops the front end of the stimulator which is applied in the implantable deep brain stimulation (DBS) for the therapy of Parkinson's disease. This stimulator adopts the low power switched-capacitor DAC accompanying with voltage-to-current transconductance amplifiers to obtain the adjustable output currents. The proposed distortion cancellation technique improves the linearity of the current stimulator. Multiple transconductance amplifiers sharing a single DAC save the circuit area. The biphasic stimulation waveform is generated from the bridge switching technique and the programmable pulse. This stimulation circuit provides the 0 approximately 165 microA current for a typical loading of 10 kΩ, 8 approximately 120 micros pulse width, and 126 approximately 244 Hz frequencies with a 0.35 microm CMOS technology at 3.3 V supply voltage. PMID:21096724

  1. Controlled electromechanical cell stimulation on-a-chip.

    PubMed

    Pavesi, Andrea; Adriani, Giulia; Rasponi, Marco; Zervantonakis, Ioannis K; Fiore, Gianfranco B; Kamm, Roger D

    2015-01-01

    Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In this work, we describe the design and fabrication of a micro-scale cell stimulator capable of simultaneously providing mechanical, electrical, and biochemical stimulation, and subsequently extracting detailed morphological and gene-expression analysis on the cellular response. This micro-device offers the opportunity to overcome previous limitations and recreate critical elements of the in vivo microenvironment in order to investigate cellular responses to three different stimulations. The platform was validated in experiments using human bone marrow mesenchymal stem cells. These experiments demonstrated the ability for inducing changes in cell morphology, cytoskeletal fiber orientation and changes in gene expression under physiological stimuli. This novel bioengineering approach can be readily applied to various studies, especially in the fields of stem cell biology and regenerative medicine. PMID:26135970

  2. Controlled electromechanical cell stimulation on-a-chip

    PubMed Central

    Pavesi, Andrea; Adriani, Giulia; Rasponi, Marco; Zervantonakis, Ioannis K.; Fiore, Gianfranco B.; Kamm, Roger D.

    2015-01-01

    Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In this work, we describe the design and fabrication of a micro-scale cell stimulator capable of simultaneously providing mechanical, electrical, and biochemical stimulation, and subsequently extracting detailed morphological and gene-expression analysis on the cellular response. This micro-device offers the opportunity to overcome previous limitations and recreate critical elements of the in vivo microenvironment in order to investigate cellular responses to three different stimulations. The platform was validated in experiments using human bone marrow mesenchymal stem cells. These experiments demonstrated the ability for inducing changes in cell morphology, cytoskeletal fiber orientation and changes in gene expression under physiological stimuli. This novel bioengineering approach can be readily applied to various studies, especially in the fields of stem cell biology and regenerative medicine. PMID:26135970

  3. Modeling rapidly rotating stars

    NASA Astrophysics Data System (ADS)

    Rieutord, M.

    2006-06-01

    We review the quest of modeling rapidly rotating stars during the past 40 years and detail the challenges to be taken up by models facing new data from interferometry, seismology, spectroscopy... We then present the progress of the ESTER project aimed at giving a physically self-consistent model for the structure and evolution of rapidly rotating stars.

  4. Variational iteration method for Bratu-like equation arising in electrospinning.

    PubMed

    He, Ji-Huan; Kong, Hai-Yan; Chen, Rou-Xi; Hu, Ming-sheng; Chen, Qiao-ling

    2014-05-25

    This paper points out that the so called enhanced variational iteration method (Colantoni & Boubaker, 2014) for a nonlinear equation arising in electrospinning and vibration-electrospinning process is the standard variational iteration method. An effective algorithm using the variational iteration algorithm-II is suggested for Bratu-like equation arising in electrospinning. A suitable choice of initial guess results in a relatively accurate solution by one or few iteration.

  5. Engagement Sensitive Visual Stimulation.

    PubMed

    Kumar, Deepesh; Dutta, Anirban; Das, Abhijit; Lahiri, Uttama

    2016-06-13

    Stroke is one of leading cause of death and disability worldwide. Early detection during golden hour and treatment of individual neurological dysfunction in stroke using easy-to-access biomarkers based on a simple-to-use, cost-effective, clinically-valid screening tool can bring a paradigm shift in healthcare, both urban and rural. In our research we have designed a quantitative automatic home-based oculomotor assessment tool that can play an important complementary role in prognosis of neurological disorders like stroke for the neurologist. Once the patient has been screened for stroke, the next step is to design proper rehabilitation platform to alleviate the disability. In addition to the screening platform, in our research, we work in designing virtual reality based rehabilitation exercise platform that has the potential to deliver visual stimulation and in turn contribute to improving one's performance. PMID:27478569

  6. Stimulated radiative laser cooling

    NASA Astrophysics Data System (ADS)

    Muys, P.

    2008-04-01

    Building a refrigerator based on the conversion of heat into optical energy is an ongoing engineering challenge. Under well-defined conditions, spontaneous anti-Stokes fluorescence of a dopant material in a host matrix is capable of lowering the host temperature. The fluorescence is conveying away a part of the thermal energy stored in the vibrational oscillations of the host lattice. In particular, applying this principle to the cooling of (solid-state) lasers opens up many potential device applications, especially in the domain of high-power lasers. In this paper, an alternative optical cooling scheme is outlined, leading to the radiative cooling of solid-state lasers. It is based on converting the thermal energy stored in the host into optical energy by means of a stimulated nonlinear process, rather than a spontaneous process. This should lead to better cooling efficiencies and a higher potential of applying the principle for device applications.

  7. Stimulated rotational Raman scattering

    NASA Astrophysics Data System (ADS)

    Parazzoli, C. G.; Rafanelli, G. L.; Capps, D. M.; Drutman, C.

    1989-03-01

    The effect of Stimulated Rotational Raman Scattering (SRRS) processes on high energy laser directed energy weapon systems was studied. The program had 3 main objectives; achieving an accurate description of the physical processes involved in SRRS; developing a numerical algorithm to confidently evaluate SRRS-induced losses in the propagation of high energy laser beams in the uplink and downlink segments of the optical trains of various strategic defense system scenarios; and discovering possible methods to eliminate, or at least reduce, the deleterious effects of SRRS on the energy deposition on target. The following topics are discussed: the motivation for the accomplishments of the DOE program; the Semiclassical Theory of Non-Resonant SRRS for Diatomic Homonuclear Molecules; and then the following appendices; Calculation of the Dipole Transition Reduced Matrix Element, Guided Tour of Hughes SRRS Code, Running the Hughes SRRS Code, and Hughes SRRS Code Listing.

  8. Myeloperoxidase Stimulates Neutrophil Degranulation.

    PubMed

    Grigorieva, D V; Gorudko, I V; Sokolov, A V; Kostevich, V A; Vasilyev, V B; Cherenkevich, S N; Panasenko, O M

    2016-08-01

    Myeloperoxidase, heme enzyme of azurophilic granules in neutrophils, is released into the extracellular space in the inflammation foci. In neutrophils, it stimulates a dose-dependent release of lactoferrin (a protein of specific granules), lysozyme (a protein of specific and azurophilic granules), and elastase (a protein of azurophilic granules). 4-Aminobenzoic acid hydrazide, a potent inhibitor of peroxidase activity of myeloperoxidase, produced no effect on neutrophil degranulation. Using signal transduction inhibitors (genistein, methoxyverapamil, wortmannin, and NiCl2), we demonstrated that myeloperoxidase-induced degranulation of neutrophils resulted from enzyme interaction with the plasma membrane and depends on activation of tyrosine kinases, phosphatidylinositol 3-kinases (PI3K), and calcium signaling. Myeloperoxidase modified by oxidative/halogenation stress (chlorinated and monomeric forms of the enzyme) lost the potency to activate neutrophil degranulation. PMID:27597056

  9. Engagement Sensitive Visual Stimulation

    PubMed Central

    Kumar, Deepesh; Dutta, Anirban; Das, Abhijit; Lahiri, Uttama

    2016-01-01

    Stroke is one of leading cause of death and disability worldwide. Early detection during golden hour and treatment of individual neurological dysfunction in stroke using easy-to-access biomarkers based on a simple-to-use, cost-effective, clinically-valid screening tool can bring a paradigm shift in healthcare, both urban and rural. In our research we have designed a quantitative automatic home-based oculomotor assessment tool that can play an important complementary role in prognosis of neurological disorders like stroke for the neurologist. Once the patient has been screened for stroke, the next step is to design proper rehabilitation platform to alleviate the disability. In addition to the screening platform, in our research, we work in designing virtual reality based rehabilitation exercise platform that has the potential to deliver visual stimulation and in turn contribute to improving one’s performance. PMID:27478569

  10. A block iterative LU solver for weakly coupled linear systems. [in fluid dynamics equations

    NASA Technical Reports Server (NTRS)

    Cooke, C. H.

    1977-01-01

    A hybrid technique, called the block iterative LU solver, is proposed for solving the linear equations resulting from a finite element numerical analysis of certain fluid dynamics problems where the equations are weakly coupled between distinct sets of variables. Either the block Jacobi iterative method or the block Gauss-Seidel iterative solver is combined with LU decomposition.

  11. Krylov iterative methods and synthetic acceleration for transport in binary statistical media

    SciTech Connect

    Fichtl, Erin D; Warsa, James S; Prinja, Anil K

    2008-01-01

    In particle transport applications there are numerous physical constructs in which heterogeneities are randomly distributed. The quantity of interest in these problems is the ensemble average of the flux, or the average of the flux over all possible material 'realizations.' The Levermore-Pomraning closure assumes Markovian mixing statistics and allows a closed, coupled system of equations to be written for the ensemble averages of the flux in each material. Generally, binary statistical mixtures are considered in which there are two (homogeneous) materials and corresponding coupled equations. The solution process is iterative, but convergence may be slow as either or both materials approach the diffusion and/or atomic mix limits. A three-part acceleration scheme is devised to expedite convergence, particularly in the atomic mix-diffusion limit where computation is extremely slow. The iteration is first divided into a series of 'inner' material and source iterations to attenuate the diffusion and atomic mix error modes separately. Secondly, atomic mix synthetic acceleration is applied to the inner material iteration and S{sup 2} synthetic acceleration to the inner source iterations to offset the cost of doing several inner iterations per outer iteration. Finally, a Krylov iterative solver is wrapped around each iteration, inner and outer, to further expedite convergence. A spectral analysis is conducted and iteration counts and computing cost for the new two-step scheme are compared against those for a simple one-step iteration, to which a Krylov iterative method can also be applied.

  12. Electrical Stimulation of Coleopteran Muscle for Initiating Flight.

    PubMed

    Choo, Hao Yu; Li, Yao; Cao, Feng; Sato, Hirotaka

    2016-01-01

    Some researchers have long been interested in reconstructing natural insects into steerable robots or vehicles. However, until recently, these so-called cyborg insects, biobots, or living machines existed only in science fiction. Owing to recent advances in nano/micro manufacturing, data processing, and anatomical and physiological biology, we can now stimulate living insects to induce user-desired motor actions and behaviors. To improve the practicality and applicability of airborne cyborg insects, a reliable and controllable flight initiation protocol is required. This study demonstrates an electrical stimulation protocol that initiates flight in a beetle (Mecynorrhina torquata, Coleoptera). A reliable stimulation protocol was determined by analyzing a pair of dorsal longitudinal muscles (DLMs), flight muscles that oscillate the wings. DLM stimulation has achieved with a high success rate (> 90%), rapid response time (< 1.0 s), and small variation (< 0.33 s; indicating little habituation). Notably, the stimulation of DLMs caused no crucial damage to the free flight ability. In contrast, stimulation of optic lobes, which was earlier demonstrated as a successful flight initiation protocol, destabilized the beetle in flight. Thus, DLM stimulation is a promising secure protocol for inducing flight in cyborg insects or biobots. PMID:27050093

  13. Electrical Stimulation of Coleopteran Muscle for Initiating Flight.

    PubMed

    Choo, Hao Yu; Li, Yao; Cao, Feng; Sato, Hirotaka

    2016-01-01

    Some researchers have long been interested in reconstructing natural insects into steerable robots or vehicles. However, until recently, these so-called cyborg insects, biobots, or living machines existed only in science fiction. Owing to recent advances in nano/micro manufacturing, data processing, and anatomical and physiological biology, we can now stimulate living insects to induce user-desired motor actions and behaviors. To improve the practicality and applicability of airborne cyborg insects, a reliable and controllable flight initiation protocol is required. This study demonstrates an electrical stimulation protocol that initiates flight in a beetle (Mecynorrhina torquata, Coleoptera). A reliable stimulation protocol was determined by analyzing a pair of dorsal longitudinal muscles (DLMs), flight muscles that oscillate the wings. DLM stimulation has achieved with a high success rate (> 90%), rapid response time (< 1.0 s), and small variation (< 0.33 s; indicating little habituation). Notably, the stimulation of DLMs caused no crucial damage to the free flight ability. In contrast, stimulation of optic lobes, which was earlier demonstrated as a successful flight initiation protocol, destabilized the beetle in flight. Thus, DLM stimulation is a promising secure protocol for inducing flight in cyborg insects or biobots.

  14. Electrical Stimulation of Coleopteran Muscle for Initiating Flight

    PubMed Central

    Choo, Hao Yu; Li, Yao; Cao, Feng; Sato, Hirotaka

    2016-01-01

    Some researchers have long been interested in reconstructing natural insects into steerable robots or vehicles. However, until recently, these so-called cyborg insects, biobots, or living machines existed only in science fiction. Owing to recent advances in nano/micro manufacturing, data processing, and anatomical and physiological biology, we can now stimulate living insects to induce user-desired motor actions and behaviors. To improve the practicality and applicability of airborne cyborg insects, a reliable and controllable flight initiation protocol is required. This study demonstrates an electrical stimulation protocol that initiates flight in a beetle (Mecynorrhina torquata, Coleoptera). A reliable stimulation protocol was determined by analyzing a pair of dorsal longitudinal muscles (DLMs), flight muscles that oscillate the wings. DLM stimulation has achieved with a high success rate (> 90%), rapid response time (< 1.0 s), and small variation (< 0.33 s; indicating little habituation). Notably, the stimulation of DLMs caused no crucial damage to the free flight ability. In contrast, stimulation of optic lobes, which was earlier demonstrated as a successful flight initiation protocol, destabilized the beetle in flight. Thus, DLM stimulation is a promising secure protocol for inducing flight in cyborg insects or biobots. PMID:27050093

  15. Spiral scan peripheral nerve stimulation.

    PubMed

    King, K F; Schaefer, D J

    2000-07-01

    Time-varying magnetic fields induce electric fields that can cause physiological stimulation. Stimulation has been empirically characterized as a function of dB/dt and duration based on experiments using trapezoidal and sinusoidal gradient waveforms with constant ramp time, amplitude, and direction. For two-dimensional (2D) spiral scans, the readout gradient waveforms are frequency- and amplitude-modulated sinusoids on two orthogonal axes in quadrature. The readout gradient waveform therefore rotates with amplitude and angular velocity that are generally not constant. It does not automatically follow that spiral stimulation thresholds can be predicted using available stimulation models. We scanned 18 normal volunteers with a 2D spiral scan and measured global thresholds for axial, sagittal, and coronal planes. We concluded that the stimulation model evaluated accurately predicts slew rate-limited spiral mean stimulation thresholds, if the effective ramp time is chosen to be the half-period at the end of the spiral readout.

  16. The precision and accuracy of iterative and non-iterative methods of photopeak integration in activation analysis, with particular reference to the analysis of multiplets

    USGS Publications Warehouse

    Baedecker, P.A.

    1977-01-01

    The relative precisions obtainable using two digital methods, and three iterative least squares fitting procedures of photopeak integration have been compared empirically using 12 replicate counts of a test sample with 14 photopeaks of varying intensity. The accuracy by which the various iterative fitting methods could analyse synthetic doublets has also been evaluated, and compared with a simple non-iterative approach. ?? 1977 Akade??miai Kiado??.

  17. Decentralized Control of Sound Radiation Using Iterative Loop Recovery

    NASA Technical Reports Server (NTRS)

    Schiller, Noah H.; Cabell, Randolph H.; Fuller, Chris R.

    2009-01-01

    A decentralized model-based control strategy is designed to reduce low-frequency sound radiation from periodically stiffened panels. While decentralized control systems tend to be scalable, performance can be limited due to modeling error introduced by the unmodeled interaction between neighboring control units. Since bounds on modeling error are not known in advance, it is difficult to ensure the decentralized control system will be robust without making the controller overly conservative. Therefore an iterative approach is suggested, which utilizes frequency-shaped loop recovery. The approach accounts for modeling error introduced by neighboring control loops, requires no communication between subsystems, and is relatively simple. The control strategy is evaluated numerically using a model of a stiffened aluminum panel that is representative of the sidewall of an aircraft. Simulations demonstrate that the iterative approach can achieve significant reductions in radiated sound power from the stiffened panel without destabilizing neighboring control units.

  18. Electron Cyclotron Emission Imaging on ITER with Rowland Circle Optics

    NASA Astrophysics Data System (ADS)

    Liu, Jason; Lee, Woochang; Leem, June-Eok; Bitter, Manfred; Park, Hyeon; Yun, Gunsu

    2015-11-01

    The implementation of advanced electron cyclotron emission imaging (ECEI) systems on the major tokamaks TEXTOR1, DIII-D2,3, KSTAR4, EAST5, and ASDEX Upgrade6 has revolutionized the diagnosis of MHD activities and improved our understanding of various instabilities. However, the conventional ECEI systems cannot be applied to ITER because of the space constraints and excessive radiation that would be encountered in the diagnostic port plugs. This paper describes an alternative optical concept that employs the Rowland circle imaging geometry to implement an advanced ECEI system on ITER that is suitable for the tight space and harsh environments of the diagnostic port plugs. Such a system would match the capabilities of conventional ECEI diagnostics and would be capable of simultaneous core and edge measurements.

  19. An iterative learning controller for nonholonomic mobile robots

    SciTech Connect

    Oriolo, G.; Panzieri, S.; Ulivi, G.

    1998-09-01

    The authors present an iterative learning controller that applies to nonholonomic mobile robots, as well as other systems that can be put in chained form. The learning algorithm exploits the fact that chained-form. The learning algorithm exploits the fact that chained-form systems are linear under piecewise-constant inputs. The proposed control scheme requires the execution of a small number of experiments to drive the system to the desired state in finite time, with nice convergence and robustness properties with respect to modeling inaccuracies as well as disturbances. To avoid the necessity of exactly reinitializing the system at each iteration, the basic method is modified so as to obtain a cyclic controller, by which the system is cyclically steered through an arbitrary sequence of states. As a case study, a carlike mobile robot is considered. Both simulation and experimental results are reported to show the performance of the method.

  20. Iterative methods for stationary convection-dominated transport problems

    SciTech Connect

    Bova, S.W.; Carey, G.F.

    1994-12-31

    It is well known that many iterative methods fail when applied to nonlinear systems of convection-dominated transport equations. Most successful methods for obtaining steady-state solutions to such systems rely on time-stepping through an artificial transient, combined with careful construction of artificial dissipation operators. These operators provide control over spurious oscillations which pollute the steady state solutions, and, in the nonlinear case, may become amplified and lead to instability. In the present study, we investigate Taylor Galerkin and SUPG-type methods and compare results for steady-state solutions to the Euler equations of gas dynamics. In particular, we consider the efficiency of different iterative strategies and present results for representative two-dimensional calculations.

  1. Progress on an ITER ECH Transmission system development and testing

    NASA Astrophysics Data System (ADS)

    Bigelow, Tim; Hanson, Greg; Rasmussen, Dave; Barker, Alan; Dukes, Carl; Killough, Stephen; Peters, Brian; Rumbolt, Robin; Schaich, Chuck; Sanabria, Roberto; McElehaney, Karen; White, John; Allison, Stephen

    2012-10-01

    Progress on further development of the ITER ECH Transmission system design and testing of waveguide components will be presented. Work on the preliminary design of the system configuration is proceeding based on the conceptual design from the ITER Organization. Requirements for precision of waveguide supports and components are being analyzed and thermal and mechanical modeling of prototype components is being performed. Several prototype components have been procured from industry and some have been tested to nearly 1 MW at 170 GHz for long pulses at JAEA in Japan. A high power test stand is being developed at ORNL to provide component, system, and instrumentation tests at 1 MW cw or higher power conditions. The high voltage power supply has been tested and 140 GHz and 170 GHz gyrotrons are expected to be operational in the near future.

  2. Decentralized control of sound radiation using iterative loop recovery.

    PubMed

    Schiller, Noah H; Cabell, Randolph H; Fuller, Chris R

    2010-10-01

    A decentralized model-based control strategy is designed to reduce low-frequency sound radiation from periodically stiffened panels. While decentralized control systems tend to be scalable, performance can be limited due to modeling error introduced by the unmodeled interaction between neighboring control units. Since bounds on modeling error are not known in advance, it is difficult to ensure the decentralized control system will be robust without making the controller overly conservative. Therefore an iterative approach is suggested, which utilizes frequency-shaped loop recovery. The approach accounts for modeling error introduced by neighboring control loops, requires no communication between subsystems, and is relatively simple. The control strategy is evaluated numerically using a model of a stiffened aluminum panel that is representative of the sidewall of an aircraft. Simulations demonstrate that the iterative approach can achieve significant reductions in radiated sound power from the stiffened panel without destabilizing neighboring control units.

  3. Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification.

    PubMed

    Tan, G Christopher; Mazzoni, Esteban O; Wichterle, Hynek

    2016-07-26

    The motor neuron progenitor domain in the ventral spinal cord gives rise to multiple subtypes of motor neurons and glial cells. Here, we examine whether progenitors found in this domain are multipotent and which signals contribute to their cell-type-specific differentiation. Using an in vitro neural differentiation model, we demonstrate that motor neuron progenitor differentiation is iteratively controlled by Notch signaling. First, Notch controls the timing of motor neuron genesis by repressing Neurogenin 2 (Ngn2) and maintaining Olig2-positive progenitors in a proliferative state. Second, in an Ngn2-independent manner, Notch contributes to the specification of median versus hypaxial motor column identity and lateral versus medial divisional identity of limb-innervating motor neurons. Thus, motor neuron progenitors are multipotent, and their diversification is controlled by Notch signaling that iteratively increases cellular diversity arising from a single neural progenitor domain. PMID:27425621

  4. Sawtooth control in ITER using ion cyclotron resonance heating

    SciTech Connect

    Chapman, I. T.; Graves, J P; Johnson, T.; Asunta, O.; Bonoli, P.; Choi, M.; Jaeger, E. F.; Jucker, M.; Sauter, O.

    2011-01-01

    Numerical modeling of the effects of ion cyclotron resonance heating (ICRH) on the stability of the internal kink mode suggests that ICRH should be considered as an essential sawtooth control tool in ITER. Sawtooth control using ICRH is achieved by directly affecting the energy of the internal kink mode rather than through modification of the magnetic shear by driving localized currents. Consequently, ICRH can be seen as complementary to the planned electron cyclotron current drive actuator, and indeed will improve the efficacy of current drive schemes. Simulations of the ICRH distribution using independent RF codes give confidence in numerical predictions that the stabilizing influence of the fusion-born alphas can be negated by appropriately tailored minority (3)He ICRH heating in ITER. Finally, the effectiveness of all sawtooth actuators is shown to increase as the q = 1 surface moves towards the manetic axis, whilst the passive stabilization arising from the alpha and NBI particles decreases.

  5. Variable frequency iteration MPPT for resonant power converters

    DOEpatents

    Zhang, Qian; Bataresh, Issa; Chen, Lin

    2015-06-30

    A method of maximum power point tracking (MPPT) uses an MPPT algorithm to determine a switching frequency for a resonant power converter, including initializing by setting an initial boundary frequency range that is divided into initial frequency sub-ranges bounded by initial frequencies including an initial center frequency and first and second initial bounding frequencies. A first iteration includes measuring initial powers at the initial frequencies to determine a maximum power initial frequency that is used to set a first reduced frequency search range centered or bounded by the maximum power initial frequency including at least a first additional bounding frequency. A second iteration includes calculating first and second center frequencies by averaging adjacent frequent values in the first reduced frequency search range and measuring second power values at the first and second center frequencies. The switching frequency is determined from measured power values including the second power values.

  6. Conceptual design of the ITER fast-ion loss detector

    NASA Astrophysics Data System (ADS)

    Garcia-Munoz, M.; Kocan, M.; Ayllon-Guerola, J.; Bertalot, L.; Bonnet, Y.; Casal, N.; Galdon, J.; Garcia Lopez, J.; Giacomin, T.; Gonzalez-Martin, J.; Gunn, J. P.; Jimenez-Ramos, M. C.; Kiptily, V.; Pinches, S. D.; Rodriguez-Ramos, M.; Reichle, R.; Rivero-Rodriguez, J. F.; Sanchis-Sanchez, L.; Snicker, A.; Vayakis, G.; Veshchev, E.; Vorpahl, Ch.; Walsh, M.; Walton, R.

    2016-11-01

    A conceptual design of a reciprocating fast-ion loss detector for ITER has been developed and is presented here. Fast-ion orbit simulations in a 3D magnetic equilibrium and up-to-date first wall have been carried out to revise the measurement requirements for the lost alpha monitor in ITER. In agreement with recent observations, the simulations presented here suggest that a pitch-angle resolution of ˜5° might be necessary to identify the loss mechanisms. Synthetic measurements including realistic lost alpha-particle as well as neutron and gamma fluxes predict scintillator signal-to-noise levels measurable with standard light acquisition systems with the detector aperture at ˜11 cm outside of the diagnostic first wall. At measurement position, heat load on detector head is comparable to that in present devices.

  7. A new automatic baseline correction method based on iterative method

    NASA Astrophysics Data System (ADS)

    Bao, Qingjia; Feng, Jiwen; Chen, Fang; Mao, Wenping; Liu, Zao; Liu, Kewen; Liu, Chaoyang

    2012-05-01

    A new automatic baseline correction method for Nuclear Magnetic Resonance (NMR) spectra is presented. It is based on an improved baseline recognition method and a new iterative baseline modeling method. The presented baseline recognition method takes advantages of three baseline recognition algorithms in order to recognize all signals in spectra. While in the iterative baseline modeling method, besides the well-recognized baseline points in signal-free regions, the 'quasi-baseline points' in the signal-crowded regions are also identified and then utilized to improve robustness by preventing the negative regions. The experimental results on both simulated data and real metabolomics spectra with over-crowded peaks show the efficiency of this automatic method.

  8. Contractive multifunctions, fixed point inclusions and iterated multifunction systems

    NASA Astrophysics Data System (ADS)

    Kunze, H. E.; La Torre, D.; Vrscay, E. R.

    2007-06-01

    We study the properties of multifunction operators that are contractive in the Covitz-Nadler sense. In this situation, such operators T possess fixed points satisfying the relation x[set membership, variant]Tx. We introduce an iterative method involving projections that guarantees convergence from any starting point x0[set membership, variant]X to a point x[set membership, variant]XT, the set of all fixed points of a multifunction operator T. We also prove a continuity result for fixed point sets XT as well as a "generalized collage theorem" for contractive multifunctions. These results can then be used to solve inverse problems involving contractive multifunctions. Two applications of contractive multifunctions are introduced: (i) integral inclusions and (ii) iterated multifunction systems.

  9. Krylov subspace iteration for eigenvalue response matrix calculations

    SciTech Connect

    Roberts, J. A.; Forget, B.

    2012-07-01

    Recent work has revisited the eigenvalue response matrix method as an approach for reactor core analyses. In its most straightforward form, the method consists of a two-level Eigen problem. An outer Picard iteration updates the k-eigenvalue, while the inner Eigen problem imposes current continuity between coarse meshes. In this paper, several Eigen solvers are evaluated for this inner problem, using several 2-D diffusion benchmarks as test cases. The results indicate both the explicitly-restarted Arnoldi and the Krylov-Schur methods are up to an order of magnitude more efficient than power iteration. This increased efficiency makes the nested eigenvalue formulation more effective than the ILU-preconditioned Newton-Krylov formulation previously studied. (authors)

  10. Investigation of statistical iterative reconstruction for dedicated breast CT

    NASA Astrophysics Data System (ADS)

    Makeev, Andrey; Das, Mini; Glick, Stephen J.

    2012-03-01

    Dedicated breast CT has great potential for improving the detection and diagnosis of breast cancer. In this study, statistical iterative reconstruction with a penalized likelihood objective function and a Huber prior are investigated for use with breast CT. This prior has two free parameters, the penalty weight and the edgepreservation threshold, that need to be evaluated to determine those values that give optimal performance. Computer simulations with breast-like phantoms were used to study these parameters using various figuresof- merit that relate to performance in detecting microcalcifications. Results suggested that a narrow range of Huber prior parameters give optimal performance. Furthermore, iterative reconstruction provided improved performance measures as compared to conventional filtered back-projection.

  11. Iterative LQG Controller Design Through Closed-Loop Identification

    NASA Technical Reports Server (NTRS)

    Hsiao, Min-Hung; Huang, Jen-Kuang; Cox, David E.

    1996-01-01

    This paper presents an iterative Linear Quadratic Gaussian (LQG) controller design approach for a linear stochastic system with an uncertain open-loop model and unknown noise statistics. This approach consists of closed-loop identification and controller redesign cycles. In each cycle, the closed-loop identification method is used to identify an open-loop model and a steady-state Kalman filter gain from closed-loop input/output test data obtained by using a feedback LQG controller designed from the previous cycle. Then the identified open-loop model is used to redesign the state feedback. The state feedback and the identified Kalman filter gain are used to form an updated LQC controller for the next cycle. This iterative process continues until the updated controller converges. The proposed controller design is demonstrated by numerical simulations and experiments on a highly unstable large-gap magnetic suspension system.

  12. Iterative method for predistortion of MRI gradient waveforms.

    PubMed

    Harkins, Kevin D; Does, Mark D; Grissom, William A

    2014-08-01

    The purpose of this work is to correct for transient gradient waveform errors in magnetic resonance imaging (MRI), whether from eddy currents, group delay, or gradient amplifier nonlinearities, which are known to affect image quality. An iterative method is proposed to minimize error between desired and measured gradient waveforms, whose success does not depend on accurate knowledge of the gradient system impulse response. The method was applied to half-pulse excitation for 2-D ultra-short echo time (UTE) imaging on a small animal MRI system and to spiral 2-D excitation on a human 7T MRI system. Predistorted gradient waveforms reduced temporal signal variation caused by excitation gradient trajectory errors in 2-D UTE, and improved the quality of excitation patterns produced by spiral excitation pulses. Iterative gradient predistortion is useful for minimizing transient gradient errors without requiring accurate characterization of the gradient system impulse response. PMID:24801945

  13. Transmission of electrons inside the cryogenic pumps of ITER injector.

    PubMed

    Veltri, P; Sartori, E

    2016-02-01

    Large cryogenic pumps are installed in the vessel of large neutral beam injectors (NBIs) used to heat the plasma in nuclear fusion experiments. The operation of such pumps can be compromised by the presence of stray secondary electrons that are generated along the beam path. In this paper, we present a numerical model to analyze the propagation of the electrons inside the pump. The aim of the study is to quantify the power load on the active pump elements, via evaluation of the transmission probabilities across the domain of the pump. These are obtained starting from large datasets of particle trajectories, obtained by numerical means. The transmission probability of the electrons across the domain is calculated for the NBI of the ITER and for its prototype Megavolt ITer Injector and Concept Advancement (MITICA) and the results are discussed. PMID:26932041

  14. Decentralized control of sound radiation using iterative loop recovery.

    PubMed

    Schiller, Noah H; Cabell, Randolph H; Fuller, Chris R

    2010-10-01

    A decentralized model-based control strategy is designed to reduce low-frequency sound radiation from periodically stiffened panels. While decentralized control systems tend to be scalable, performance can be limited due to modeling error introduced by the unmodeled interaction between neighboring control units. Since bounds on modeling error are not known in advance, it is difficult to ensure the decentralized control system will be robust without making the controller overly conservative. Therefore an iterative approach is suggested, which utilizes frequency-shaped loop recovery. The approach accounts for modeling error introduced by neighboring control loops, requires no communication between subsystems, and is relatively simple. The control strategy is evaluated numerically using a model of a stiffened aluminum panel that is representative of the sidewall of an aircraft. Simulations demonstrate that the iterative approach can achieve significant reductions in radiated sound power from the stiffened panel without destabilizing neighboring control units. PMID:20968346

  15. Engineering and manufacturing of ITER first mirror mock-ups

    SciTech Connect

    Joanny, M.; Travere, J. M.; Salasca, S.; Corre, Y.; Marot, L.; Thellier, C.; Gallay, G.; Cammarata, C.; Passier, B.; Ferme, J. J.

    2010-10-15

    Most of the ITER optical diagnostics aiming at viewing and monitoring plasma facing components will use in-vessel metallic mirrors. These mirrors will be exposed to a severe plasma environment and lead to an important tradeoff on their design and manufacturing. As a consequence, investigations are carried out on diagnostic mirrors toward the development of optimal and reliable solutions. The goals are to assess the manufacturing feasibility of the mirror coatings, evaluate the manufacturing capability and associated performances for the mirrors cooling and polishing, and finally determine the costs and delivery time of the first prototypes with a diameter of 200 and 500 mm. Three kinds of ITER candidate mock-ups are being designed and manufactured: rhodium films on stainless steel substrate, molybdenum on TZM substrate, and silver films on stainless steel substrate. The status of the project is presented in this paper.

  16. Full orbit calculation for lost alpha particle measurement on ITER

    SciTech Connect

    Funaki, D.; Isobe, M.; Nishiura, M.; Sato, Y.; Okamoto, A.; Kobuchi, T.; Kitajima, S.; Sasao, M.

    2008-10-15

    An orbit following calculation code with full gyromotion under the ITER magnetic field configuration has been developed to investigate escaping alpha particle orbits in ITER and to determine the geometrical arrangement for alpha particle detection. The code contained the full geometrical information of the first wall panels. It was carefully investigated whether an alpha particle escaping from the plasma through the last closed flux surface does not touch or intersect the first wall boundary before reaching the detection point. Candidates of blanket module modification have been studied to achieve effective measurement geometry for escaping alpha particle detection. The calculations showed that direct orbit loss and banana diffusion can be detected with a probe head recessed from the first wall surface.

  17. Transmission of electrons inside the cryogenic pumps of ITER injector.

    PubMed

    Veltri, P; Sartori, E

    2016-02-01

    Large cryogenic pumps are installed in the vessel of large neutral beam injectors (NBIs) used to heat the plasma in nuclear fusion experiments. The operation of such pumps can be compromised by the presence of stray secondary electrons that are generated along the beam path. In this paper, we present a numerical model to analyze the propagation of the electrons inside the pump. The aim of the study is to quantify the power load on the active pump elements, via evaluation of the transmission probabilities across the domain of the pump. These are obtained starting from large datasets of particle trajectories, obtained by numerical means. The transmission probability of the electrons across the domain is calculated for the NBI of the ITER and for its prototype Megavolt ITer Injector and Concept Advancement (MITICA) and the results are discussed.

  18. Soft Error Vulnerability of Iterative Linear Algebra Methods

    SciTech Connect

    Bronevetsky, G; de Supinski, B

    2008-01-19

    Devices are increasingly vulnerable to soft errors as their feature sizes shrink. Previously, soft error rates were significant primarily in space and high-atmospheric computing. Modern architectures now use features so small at sufficiently low voltages that soft errors are becoming important even at terrestrial altitudes. Due to their large number of components, supercomputers are particularly susceptible to soft errors. Since many large scale parallel scientific applications use iterative linear algebra methods, the soft error vulnerability of these methods constitutes a large fraction of the applications overall vulnerability. Many users consider these methods invulnerable to most soft errors since they converge from an imprecise solution to a precise one. However, we show in this paper that iterative methods are vulnerable to soft errors, exhibiting both silent data corruptions and poor ability to detect errors. Further, we evaluate a variety of soft error detection and tolerance techniques, including checkpointing, linear matrix encodings, and residual tracking techniques.

  19. Iterative procedures for wave propagation in the frequency domain

    SciTech Connect

    Kim, Seongjai; Symes, W.W.

    1996-12-31

    A parallelizable two-grid iterative algorithm incorporating a domain decomposition (DD) method is considered for solving the Helmholtz problem. Since a numerical method requires choosing at least 6 to 8 grid points per wavelength, the coarse-grid problem itself is not an easy task for high frequency applications. We solve the coarse-grid problem using a nonoverlapping DD method. To accelerate the convergence of the iteration, an artificial damping technique and relaxation parameters are introduced. Automatic strategies for finding efficient parameters are discussed. Numerical results are presented to show the effectiveness of the method. It is numerically verified that the rate of convergence of the algorithm depends on the wave number sub-linearly and does not deteriorate as the mesh size decreases.

  20. Optimization studies of the ITER low field side reflectometer

    SciTech Connect

    Hanson, Gregory R; Wilgen, John B; Bigelow, Tim S; Diem, Stephanie J

    2010-01-01

    Microwave reflectometry will be used on ITER to measure the electron density profile, density fluctuations due to MHD/turbulence, ELM density transients, and as a L-H transition monitor. The ITER low field side (LFS) reflectometer system will measure both core and edge quantities using multiple antenna arrays spanning frequency ranges of 15-155 GHz for the O-mode system and 55-220 GHz for the X-mode system. Optimization studies using the GENRAY ray-tracing code have been done for edge and core measurements. The reflectometer launchers will utilize the HE11 mode launched from circular corrugated waveguide. The launched beams are assumed to be Gaussian with a beam waist diameter of 0.643 times the waveguide diameter. Optimum launcher size and placement are investigated by computing the antenna coupling between launchers, assuming the launched and received beams have a Gaussian beam pattern.