Evolving Approaches to the Ethical Management of Genomic Data

PubMed Central

Boyer, Joy T.; Sun, Kathie Y.

2013-01-01

The ethical landscape in the field of genomics is rapidly shifting. Plummeting sequencing costs, along with ongoing advances in bioinformatics, now make it possible to generate an enormous volume of genomic data about vast numbers of people. The informational richness, complexity, and frequently uncertain meaning of these data, coupled with evolving norms surrounding the sharing of data and samples and persistent privacy concerns, have generated a range of approaches to the ethical management of genomic information. As calls increase for the expanded use of broad or even open consent, and as controversy grows about how best to handle incidental genomic findings, these approaches, informed by normative analysis and empirical data, will continue to evolve alongside the science. PMID:23453621

"Capping Off" the Development of Graduate Capabilities in the Final Semester Unit for Biological Science Students: Review and Recommendations

ERIC Educational Resources Information Center

Firn, Jennifer

2015-01-01

Biology is the most rapidly evolving scientific field of the 21st century. Biology graduates must be able to integrate concepts and collaborate outside their discipline to solve the most pressing questions of our time, e.g. world hunger, malnutrition, climate change, infectious disease and biosecurity. University educators are attempting to…

Incorporation of Cross-Disciplinary Teaching and a Wiki Research Project to Engage Undergraduate Students' to Develop Information Literacy, Critical Thinking, and Communication Skills

ERIC Educational Resources Information Center

Crist, Courtney A.; Duncan, Susan E.; Bianchi, Laurie M.

2017-01-01

A Wiki research project was created in the Functional Foods for Health (FST/HNFE 2544) as an instructional tool and assignment for improving undergraduate students' proficiency in evaluating appropriate information sources for rapidly evolving science and research. The project design targeted improving students' information literacy skills…

Status and prospects for LiDAR remote sensing of forested ecosystems

Treesearch

M. A. Wulder; N. C. Coops; A. T. Hudak; F. Morsdorf; R. Nelson; G. Newnham; M. Vastaranta

2013-01-01

The science associated with the use of airborne and satellite Light Detection and Ranging (LiDAR) to remotely sense forest structure has rapidly progressed over the past decade. LiDAR has evolved from being a poorly understood, potentially useful tool to an operational technology in a little over a decade, and these instruments have become a major success story in...

Metal stable isotopes in low-temperature systems: A primer

USGS Publications Warehouse

Bullen, T.D.; Eisenhauer, A.

2009-01-01

Recent advances in mass spectrometry have allowed isotope scientists to precisely determine stable isotope variations in the metallic elements. Biologically infl uenced and truly inorganic isotope fractionation processes have been demonstrated over the mass range of metals. This Elements issue provides an overview of the application of metal stable isotopes to low-temperature systems, which extend across the borders of several science disciplines: geology, hydrology, biology, environmental science, and biomedicine. Information on instrumentation, fractionation processes, data-reporting terminology, and reference materials presented here will help the reader to better understand this rapidly evolving field.

2010 MULTIPHOTON PROCESSES GORDON RESEARCH CONFERENCE, JUNE 6-11, 2010, TILTON, NH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mette Gaarde

2010-06-11

The Gordon Research Conference on Multiphoton Processes will be held for the 15th time in 2010. The meeting continues to evolve as it embraces both the rapid technological and intellectual growth in the field as well as the multi-disciplinary expertise of the participants. This time the sessions will focus on: (1) Ultrafast coherent control; (2) Free-electron laser experiments and theory; (3) Generation of harmonics and attosecond pulses; (4) Ultrafast imaging; (5) Applications of very high intensity laser fields; (6) Strong-field processes in molecules and solids; (7) Attosecond science; and (8) Controlling light. The scientific program will blur traditional disciplinary boundariesmore » as the presenters and discussion leaders involve chemists, physicists, and optical engineers, representing both experiment and theory. The broad range of expertise and different perspectives of attendees should provide a stimulating and unique environment for solving problems and developing new ideas in this rapidly evolving field.« less

Reflective Practice and Readiness for Self-Directed Learning in Anesthesiology Residents Training in the United States

ERIC Educational Resources Information Center

Miller Juve, Amy Katrina

2012-01-01

The science and technology of medicine is evolving and changing at a fast pace. With these rapid advances, it is paramount that physicians maintain a level of medical knowledge that is current and relevant to their practice in order to address the challenges of patient care and safety. One way physicians can maintain a level of medical knowledge…

The Effect of Political Science Education on Political Trust and Interest: Results from a 5-Year Panel Study

ERIC Educational Resources Information Center

Claes, Ellen; Hooghe, Marc

2017-01-01

Citizenship education has evolved substantially in recent decades, with a rapid proliferation of education forms and approaches. The currently available evaluation studies, however, do not allow us to determine what kind of approach can be considered as a best practice for schools and education systems. In this article, we rely on the results of a…

Utilizing social media for informal ocean conservation and education: The BioOceanography Project

NASA Astrophysics Data System (ADS)

Payette, J.

2016-02-01

Science communication through the use of social media is a rapidly evolving and growing pursuit in academic and scientific circles. Online tools and social media are being used in not only scientific communication but also scientific publication, education, and outreach. Standards and usage of social media as well as other online tools for communication, networking, outreach, and publication are always in development. Caution and a conservative attitude towards these novel "Science 2.0" tools is understandable because of their rapidly changing nature and the lack of professional standards for using them. However there are some key benefits and unique ways social media, online systems, and other Open or Open Source technologies, software, and "Science 2.0" tools can be utilized for academic purposes such as education and outreach. Diverse efforts for ocean conservation and education will continue to utilize social media for a variety of purposes. The BioOceanography project is an informal communication, education, outreach, and conservation initiative created for enhancing knowledge related to Oceanography and Marine Science with an unbiased yet conservation-minded approach and in an Open Source format. The BioOceanography project is ongoing and still evolving, but has already contributed to ocean education and conservation communication in key ways through a concerted web presence since 2013, including a curated Twitter account @_Oceanography and BioOceanography blog style website. Social media tools like those used in this project, if used properly can be highly effective and valuable for encouraging students, networking with researchers, and educating the general public in Oceanography.

US EPA Digital Science: An Evolution

NASA Astrophysics Data System (ADS)

Ziegler, C. R.; Burch, K.; Laniak, G.; Vega, A.; Harten, P.; Kremer, J.; Brookes, A.; Yuen, A.; Subramanian, B.

2015-12-01

The United States Environmental Protection Agency's (US EPA) digital science "enterprise" plays a critical role in US EPA's efforts to achieve its mission to protect human health and the environment. This enterprise is an evolving cross-disciplinary research and development construct, with social and institutional dimensions. It has an active development community and produces a portfolio of digital science products including decision support tools, data repositories, Web interfaces, and more. Earth sciences and sustainable development organizations from around the world - including US government agencies - have achieved various levels of success in taking advantage of the rapidly-evolving digital age. Efficiency, transparency and ability to innovate are tied to an organization's digital maturity and related social characteristics. Concepts like participatory web, data and software interoperability, global technology transfer, ontological harmonization, big data, scaling, re-use and open science are no longer "new and emerging." They have emerged and - in some cases - are tied to US government directives. We assess maturity, describe future scenarios, discuss new initiatives and outline steps for better leveraging the information age to more effectively and efficiently achieve US EPA's mission. The views expressed herein are those of the authors and do not necessarily reflect the views or policies of the organizations for which they work and/or represent.

The progress on time & frequency during the past 5 decades

NASA Astrophysics Data System (ADS)

Wang, Zheng-Ming

2002-06-01

The number and variety of applications using precise timing are astounding and increasing along with the new technology in communication, computer science, space science as well as in other fields. The world has evolved into the information age, and precise timing is at the heart of managing the flow of that information, which prompts the progress on precise timing itself rapidly. The development of time scales, UT1 determination, frequency standards, time transfer and the time dissemination for the past half century in the world and in China are described in this paper. The expectation in this field is discussed.

Oceanic Chemistry and Biology Group (ONR Code 422CB) Program Science Report, FY 81,

DTIC Science & Technology

1982-03-01

instruments to provide the tools needed by the marine chemical conmunity to address small scale length features and rapidly f evolving phenomena. Underway...Through a combined application of field and laboratory studies an attempt is being made to identify the marine abiotic processes which are potentially...Biodeterioration Dissolved Organics Particulate Matter Bioluminescence HEBBLE Sediment Traps Bioturbation Marine Biology STIE Boring Organisms Marine Chemistry

Detection of genomic rearrangements in cucumber using genomecmp software

NASA Astrophysics Data System (ADS)

Kulawik, Maciej; Pawełkowicz, Magdalena Ewa; Wojcieszek, Michał; PlÄ der, Wojciech; Nowak, Robert M.

2017-08-01

Comparative genomic by increasing information about the genomes sequences available in the databases is a rapidly evolving science. A simple comparison of the general features of genomes such as genome size, number of genes, and chromosome number presents an entry point into comparative genomic analysis. Here we present the utility of the new tool genomecmp for finding rearrangements across the compared sequences and applications in plant comparative genomics.

Landsat Science Team: 2016 winter meeting summary

USGS Publications Warehouse

Schroeder, Todd; Loveland, Thomas; Wulder, Michael A.; Irons, James R.

2016-01-01

The winter meeting of the joint U.S. Geological Survey (USGS)–NASA Landsat Science Team (LST) was held January 12-14, 2016, at Virginia Tech University in Blacksburg, VA. LST co-chairs Tom Loveland [USGS’s Earth Resources Observation and Science Data Center (EROS)—Senior Scientist] and Jim Irons [NASA’s Goddard Space Flight Center (GSFC)—Landsat 8 Project Scientist] welcomed more than 50 participants to the three-day meeting. The main objectives of this meeting focused on identifying priorities and approaches to improve the global moderate-resolution satellite record. Overall, the meeting was geared more towards soliciting team member recommendations on several rapidly evolving issues, than on providing updates on individual research activities. All the presentations given at the meeting are available at landsat.usgs. gov//science_LST_january2016.php.

The Co-evolution of Climate Models and the Intergovernmental Panel on Climate Change

NASA Astrophysics Data System (ADS)

Somerville, R. C.

2010-12-01

As recently as the 1950s, global climate models, or GCMs, did not exist, and the notion that man-made carbon dioxide might lead to significant climate change was not regarded as a serious possibility by most experts. Today, of course, the prospect or threat of exactly this type of climate change dominates the science and ranks among the most pressing issues confronting all mankind. Indeed, the prevailing scientific view throughout the first half of the twentieth century was that adding carbon dioxide to the atmosphere would have only a negligible effect on climate. The science of climate change caused by atmospheric carbon dioxide changes has thus undergone a genuine revolution. An extraordinarily rapid development of global climate models has also characterized this period, especially in the three decades since about 1980. In these three decades, the number of GCMs has greatly increased, and their physical and computational aspects have both markedly improved. Modeling progress has been enabled by many scientific advances, of course, but especially by a massive increase in available computer power, with supercomputer speeds increasing by roughly a factor of a million in the three decades from about 1980 to 2010. This technological advance has permitted a rapid increase in the physical comprehensiveness of GCMs as well as in spatial computational resolution. In short, GCMs have dramatically evolved over time, in exactly the same recent period as popular interest and scientific concern about anthropogenic climate change have markedly increased. In parallel, a unique international organization, the Intergovernmental Panel on Climate Change, or IPCC, has also recently come into being and also evolved rapidly. Today, the IPCC has become widely respected and globally influential. The IPCC was founded in 1988, and its history is thus even shorter than that of GCMs. Yet, its stature today is such that a series of IPCC reports assessing climate change science has already been endorsed by many leading scientific professional societies and academies of science worldwide. These reports are considered as definitive summaries of the state of the science. In 2007, in recognition of its exceptional accomplishments, the IPCC shared the Nobel Peace Prize equally with Al Gore. The present era is characterized not only by the reality and seriousness of human-caused climate change, but also by a young yet powerful science that enables us to understand much about the climate change that has occurred already and that awaits in the future. The development of GCMs is a critical part of the scientific story, and the development of the IPCC is a key factor in connecting the science to the perceptions and priorities of the global public and policymakers. GCMs and the IPCC have co-evolved and strongly influenced one another, as both scientists and the world at large have worked to confront the challenge of climate change.

Engineering approaches to immunotherapy.

PubMed

Swartz, Melody A; Hirosue, Sachiko; Hubbell, Jeffrey A

2012-08-22

As the science of immunology grows increasingly mechanistic, motivation for developing quantitative, design-based engineering approaches has also evolved, both for therapeutic interventions and for elucidating immunological pathways in human disease. This has seeded the nascent field of "immunoengineering," which seeks to apply engineering analyses and design approaches to problems in translational immunology. For example, cell engineers are creating ways to tailor and use immune cells as living therapeutics; protein engineers are devising new methods of rapid antibody discovery; biomaterials scientists are guiding vaccine delivery and immune-cell activation with novel constructs; and systems immunologists are deciphering the evolution and maintenance of T and B cell receptor repertoires, which could help guide vaccine design. The field is multidisciplinary and collaborative, with engineers and immunologists working together to better understand and treat disease. We discuss the scientific progress in this young, yet rapidly evolving research area, which has yielded numerous start-up companies that are betting on impact in clinical and commercial translation in the near future.

Treatment of anemia in chronic kidney disease: known, unknown, and both.

PubMed

Foley, Robert N

2011-01-01

Erythropoiesis is a rapidly evolving research arena and several mechanistic insights show therapeutic promise. In contrast with the rapid advance of mechanistic science, optimal management of anemia in patients with chronic kidney disease remains a difficult and polarizing issue. Although several large hemoglobin target trials have been performed, optimal treatment targets remain elusive, because none of the large trials to date have unequivocally identified differences in primary outcome rates or death rates, and because other reported outcomes indicate the potential for harm (rates of stroke, early requirement for dialysis, and vascular access thrombosis) and benefit (reductions in transfusion requirements and fatigue).

Space Biology in the 21st century

NASA Technical Reports Server (NTRS)

Halstead, Thora W.; Krauss, Robert W.

1990-01-01

Space Biology is poised to make significant contributions to science in the next century. A carefully crafted, but largely ground-based, program in the United States has evolved major questions that require answers through experiments in space. Science, scientists, and the new long-term spacecrafts designed by NASA will be available for the first time to mount a serious Space Biology effort. The scientific challenge is of such importance that success will provide countless benefits to biologically dependent areas such as medicine, food, and commerce in the decades ahead. The international community is rapidly expanding its role in this field. The United States should generate the resources that will allow progress in Space Biology to match the recognized progress made in aeronautics and the other space sciences.

Current Developments in Machine Learning Techniques in Biological Data Mining.

PubMed

Dumancas, Gerard G; Adrianto, Indra; Bello, Ghalib; Dozmorov, Mikhail

2017-01-01

This supplement is intended to focus on the use of machine learning techniques to generate meaningful information on biological data. This supplement under Bioinformatics and Biology Insights aims to provide scientists and researchers working in this rapid and evolving field with online, open-access articles authored by leading international experts in this field. Advances in the field of biology have generated massive opportunities to allow the implementation of modern computational and statistical techniques. Machine learning methods in particular, a subfield of computer science, have evolved as an indispensable tool applied to a wide spectrum of bioinformatics applications. Thus, it is broadly used to investigate the underlying mechanisms leading to a specific disease, as well as the biomarker discovery process. With a growth in this specific area of science comes the need to access up-to-date, high-quality scholarly articles that will leverage the knowledge of scientists and researchers in the various applications of machine learning techniques in mining biological data.

Can multilayer brain networks be a real step forward?. Comment on "Network science of biological systems at different scales: A review" by M. Gosak et al.

NASA Astrophysics Data System (ADS)

Buldú, Javier M.; Papo, David

2018-03-01

Over the last two decades Network Science has become one of the most active fields in science, whose growth has been supported by four fundamental pillars: statistical physics, nonlinear dynamics, graph theory and Big Data [1]. Initially concerned with analyzing the structure of networks, Network Science rapidly turned its attention, focused on the implications of network topology, on the dynamics of and processes unfolding on networked systems, greatly improving our understanding of diffusion, synchronization, epidemics and information transmission in complex systems [2]. The network approach typically considered complex systems as evolving in a vacuum; however real networks are generally not isolated systems, but are in continuous and evolving contact with other networks, with which they interact in multiple qualitative different and typically time-varying ways. These systems can then be represented as a collection of subsystems with connectivity layers, which are simply collapsed when considering the traditional monolayer representation. Surprisingly, such an "unpacking" of layers has proven to bear profound consequences on the structural and dynamical properties of networks, leading for instance to counter-intuitive synchronization phenomena, where maximization synchronization is achieved through strategies opposite of those maximizing synchronization in isolated networks [3].

Expanding the reach of probiotics through social enterprises.

PubMed

Reid, G; Kort, R; Alvarez, S; Bourdet-Sicard, R; Benoit, V; Cunningham, M; Saulnier, D M; van Hylckama Vlieg, J E T; Verstraelen, H; Sybesma, W

2018-05-25

The rapid rise in microbiome and probiotic science has led to estimates of product creation and sales exceeding $50 billion within five years. However, many people do not have access to affordable products, and regulatory agencies have stifled progress. The objective of a discussion group at the 2017 meeting of the International Scientific Association for Probiotics and Prebiotics was to identify mechanisms to confer the benefits of probiotics to a larger portion of the world's population. Three initiatives, built around fermented food, were discussed with different methods of targeting populations that face enormous challenges of malnutrition, infectious disease, poverty and violent conflict. As new candidate probiotic strains emerge, and the market diversifies towards more personalised interventions, manufacturing processes will need to evolve. Information dissemination through scientific channels and social media is projected to provide consumers and healthcare providers with rapid access to clinical results, and to identify the nearest location of sites making new and affordable probiotic food and supplements. This rapid translation of science to individual well-being will not only expand the beneficiaries of probiotics, but also fuel new social enterprises and economic business models.

Exploring the Cosmic Dawn, Galaxy Evolution, and Exotic Stellar Deaths with Rapid GRB Follow-Up Observations

NASA Astrophysics Data System (ADS)

Berger, Edo; Cenko, Stephen; Schmidt, Brian; Perley, Daniel; Berger, Edo; Fox, Derek; Fruchter, Andrew; Bloom, Joshua; Prochaska, Jason X.; Lopez, Sebastian; Cobb, Bethany; Roth, Kathy; Levan, Andrew; Tanvir, Nial; Rapoport, Sharon; Yuan, Fang; Chornock, Ryan; Wen-Fai, Fong; Morgan, Adam; Wiersema, Klaas; Cucchiara, Antonino

2013-08-01

The study of gamma-ray burst (GRB) afterglows, host galaxies, and associated supernovae (SNe) sheds light on a wide range of open questions in astrophysics, ranging from the deaths of massive stars to cosmic chemical enrichment and the reionization epoch, and soon, the electromagnetic (EM) counterparts of gravitational wave (GW) sources. Over the past decade, Gemini has played a leading role in all aspects of GRB science through its combination of rapid-response spectroscopy and imaging coupled with deep late-time host galaxy, afterglow, and GRB-SN follow-up. Here, we propose to step forward in our long-standing program of ToO observations, with this proposal focusing on "Rapid ToO" science, observations at t <˜ 1 day. In conjunction with an array of multi-wavelength EM facilities, we focus on three key science topics: (1) Identification, characterization, and exploitation of high-redshift GRBs in order to study the evolving IGM and galaxy populations at these redshifts; (2) Studies of short GRB afterglows and their environments to yield insight into the nature of their progenitor population, for connection with forthcoming GW facilities; and (3) Observation of exceptionally energetic bursts detected by the Fermi-LAT instrument, to test models of burst engines and enable their use as testbeds for quantum gravity effects.

Exploring the Cosmic Dawn, Galaxy Evolution, and Exotic Stellar Deaths with Rapid GRB Follow-Up Observations

NASA Astrophysics Data System (ADS)

Berger, Edo; Fox, Derek; Chornock, Ryan; Fong, Wen-Fai; Cobb, Bethany; Cenko, Brad; Perley, Daniel; Bloom, Joshua; Prochaska, Jason X.; Morgan, Adam; Cucchiara, Antonino; Levan, Andrew; Tanvir, Nial; Fruchter, Andrew; Lopez, Sebastian; Wiersema, Klaas; Roth, Kathy

2014-02-01

The study of gamma-ray burst (GRB) afterglows, host galaxies, and associated supernovae (SNe) sheds light on a wide range of open questions in astrophysics, ranging from the deaths of massive stars to cosmic chemical enrichment and the reionization epoch, and soon, the electromagnetic (EM) counterparts of gravitational wave (GW) sources. Over the past decade, Gemini has played a leading role in all aspects of GRB science through its combination of rapid-response spectroscopy and imaging coupled with deep late-time host galaxy, afterglow, and GRB-SN follow-up. Here, we propose to step forward in our long-standing program of ToO observations, with this proposal focusing on "Rapid ToO" science, observations at t <˜ 1 day. In conjunction with an array of multi-wavelength EM facilities, we focus on three key science topics: (1) Identification, characterization, and exploitation of high-redshift GRBs in order to study the evolving IGM and galaxy populations at these redshifts; (2) Studies of short GRB afterglows and their environments to yield insight into the nature of their progenitor population, for connection with forthcoming GW facilities; and (3) Observation of exceptionally energetic bursts detected by the Fermi-LAT instrument, to test models of burst engines and enable their use as testbeds for quantum gravity effects.

Techniques, problems and uses of mega-geomorphological mapping

NASA Technical Reports Server (NTRS)

Embleton, C.

1985-01-01

A plea for a program of global geomorphological mapping based on remote sensing data is presented. It is argued that the program is a necessary step in bringing together the rapidly evolving concepts of plate tectonics with the science of geomorphology. Geomorphologists are urged to bring temporal scales into their subject and to abandon their recent isolation from tectonics and geological history. It is suggested that a start be made with a new geomorphological map of Europe, utilizing the latest space technology.

Assessment of a Strategic Partnership Between the U.S. Department of Homeland Security Science and Technology Directorate and the U.S. Army Developmental Test Command

DTIC Science & Technology

2011-05-01

creation of a new material acquisition system. Although the DHS material acquisition system is not fully formed, it is rapidly evolving. Much like...basis to continue or grow in the success of the organization. These strengths can be as tangible as facilities or as intangible as intellectual...reports is the struggle to develop the DHS acquisition workforce. The acquisition workforce in DHS is currently growing , but is only concentrated on

Rapid prototyping for biomedical engineering: current capabilities and challenges.

PubMed

Lantada, Andrés Díaz; Morgado, Pilar Lafont

2012-01-01

A new set of manufacturing technologies has emerged in the past decades to address market requirements in a customized way and to provide support for research tasks that require prototypes. These new techniques and technologies are usually referred to as rapid prototyping and manufacturing technologies, and they allow prototypes to be produced in a wide range of materials with remarkable precision in a couple of hours. Although they have been rapidly incorporated into product development methodologies, they are still under development, and their applications in bioengineering are continuously evolving. Rapid prototyping and manufacturing technologies can be of assistance in every stage of the development process of novel biodevices, to address various problems that can arise in the devices' interactions with biological systems and the fact that the design decisions must be tested carefully. This review focuses on the main fields of application for rapid prototyping in biomedical engineering and health sciences, as well as on the most remarkable challenges and research trends.

Ecoinformatics: supporting ecology as a data-intensive science.

PubMed

Michener, William K; Jones, Matthew B

2012-02-01

Ecology is evolving rapidly and increasingly changing into a more open, accountable, interdisciplinary, collaborative and data-intensive science. Discovering, integrating and analyzing massive amounts of heterogeneous data are central to ecology as researchers address complex questions at scales from the gene to the biosphere. Ecoinformatics offers tools and approaches for managing ecological data and transforming the data into information and knowledge. Here, we review the state-of-the-art and recent advances in ecoinformatics that can benefit ecologists and environmental scientists as they tackle increasingly challenging questions that require voluminous amounts of data across disciplines and scales of space and time. We also highlight the challenges and opportunities that remain. Copyright © 2011 Elsevier Ltd. All rights reserved.

Review and classification of variability analysis techniques with clinical applications.

PubMed

Bravi, Andrea; Longtin, André; Seely, Andrew J E

2011-10-10

Analysis of patterns of variation of time-series, termed variability analysis, represents a rapidly evolving discipline with increasing applications in different fields of science. In medicine and in particular critical care, efforts have focussed on evaluating the clinical utility of variability. However, the growth and complexity of techniques applicable to this field have made interpretation and understanding of variability more challenging. Our objective is to provide an updated review of variability analysis techniques suitable for clinical applications. We review more than 70 variability techniques, providing for each technique a brief description of the underlying theory and assumptions, together with a summary of clinical applications. We propose a revised classification for the domains of variability techniques, which include statistical, geometric, energetic, informational, and invariant. We discuss the process of calculation, often necessitating a mathematical transform of the time-series. Our aims are to summarize a broad literature, promote a shared vocabulary that would improve the exchange of ideas, and the analyses of the results between different studies. We conclude with challenges for the evolving science of variability analysis.

Review and classification of variability analysis techniques with clinical applications

PubMed Central

2011-01-01

Analysis of patterns of variation of time-series, termed variability analysis, represents a rapidly evolving discipline with increasing applications in different fields of science. In medicine and in particular critical care, efforts have focussed on evaluating the clinical utility of variability. However, the growth and complexity of techniques applicable to this field have made interpretation and understanding of variability more challenging. Our objective is to provide an updated review of variability analysis techniques suitable for clinical applications. We review more than 70 variability techniques, providing for each technique a brief description of the underlying theory and assumptions, together with a summary of clinical applications. We propose a revised classification for the domains of variability techniques, which include statistical, geometric, energetic, informational, and invariant. We discuss the process of calculation, often necessitating a mathematical transform of the time-series. Our aims are to summarize a broad literature, promote a shared vocabulary that would improve the exchange of ideas, and the analyses of the results between different studies. We conclude with challenges for the evolving science of variability analysis. PMID:21985357

On NAAMP and the use of the Internet as a forum for evolving science

USGS Publications Warehouse

Schmieder, R.

1996-01-01

Traditionally, science has been communicated through peerreviewed hardcopy. With the rapid growth of internet technology, many new potentials for sharing and evolution of ideas are possible: open, low cost communication between researchers, both accredited and amateur, may allow not joint problem solving at scales previously not possible. Conservation especially, is a dynamic field which may benefit from such rapid dissemination of information. However, among many concerns for the use of this media include 1) lack of peer review, 2) potential for , 3) dissemination of misinformation, especially when dealing with charismatic taxa 4) the possibility of creating an apparent need for an exciting technology, 5) implications of sharing data, 6) potential for distraction and additional concerns added by exposure to media and public attention, and 7) overall gain to effort ratio. With the increased facility of commmunication, feedback from the implementation of NAAMP III Online will help guide the direction and media choice of future conferences.

Citizen Science in Planetary Sciences: Intersection of Scientific Research and Amateur Networks

NASA Astrophysics Data System (ADS)

Yanamandra-Fisher, Padma A.

2014-11-01

The Pro-Am Collaborative Astronomy (PACA) project evolved from the observational campaign of C/2012 S1 or C/ISON in 2013. Following the success of the professional-amateur astronomer collaboration in scientific research via social media, it is now implemented in other comet observing campaigns. While PACA identifies a consistent collaborative approach to pro-am collaborations, given the volume of data generated for each campaign, new ways of rapid data analysis, mining access and storage are needed. Several interesting results emerged from the synergistic inclusion of both social media and amateur astronomers:(1) the establishment of a network of astronomers and related professionals, that canbe galvanized into action on short notice to support observing campaigns;(2) assist in various science investigations pertinent to the campaign;(3) provide an alert-sounding mechanism should the need arise;(4) immediate outreach and dissemination of results via our media/blogger members;(5) provide a forum for discussions between the imagers and modelers to helpstrategize the observing campaign for maximum benefit.In 2014, two new comet observing campaigns involving pro-am collaborations have been initiated: (1) C/2013 A1 (C/SidingSpring) and (2) 67P/Churyumov-Gerasimenko (CG), target for ESA/Rosetta mission. The evolving need for individual customized observing campaigns has been incorporated into the evolution of PACA portal that currently is focused on comets: from supporting observing campaigns of current comets, legacy data, historical comets; interconnected with social media and a set of shareable documents addressing observational strategies; consistent standards for data; data access, use, and storage, to align with the needs of professional observers. The integration of science, observations by professional and amateur astronomers, and various social media provides a dynamic and evolving collaborative partnership between professional and amateur astronomers. The empowerment of amateur astronomers vis-à-vis their partnerships with the professional scientists creates a new demographic of data scientists, enabling citizen science of the integrated data from both the professional and amateur communities.

Why medical research needs a new specialty of 'pure medical science'.

PubMed

Charlton, Bruce G

2006-01-01

Sciences tend to go through boom and bust phases. Following decades of rapid expansion, medical science is now due for a collapse in overall funding. Furthermore, there has been a decline in the rate of therapeutic innovation, with fewer significant breakthroughs and little progress in several major areas of medicine such as oncology, psychiatry and autoimmune disorders. Mainstream medical research has gradually evolved into a form similar to industrial research and development (R&D), aiming at steady, reliable, predictable progress by ringing minor variations on existing approaches. Where this risk-averse approach is failing, a more speculative strategy is indicated. A new research specialty of 'pure medical science' would aim to seek radical new theories, technologies and therapies, and subject these to professional evaluation to the point where they can be applied in practice by more mainstream 'applied' medical scientists. A specialty of 'pure medical science' might be launched by financial support from patrons who wish to be associated with an elite new medical research discipline.

Contextual influences on animal decision-making: Significance for behavior-based wildlife conservation and management.

PubMed

Owen, Megan A; Swaisgood, Ronald R; Blumstein, Daniel T

2017-01-01

Survival and successful reproduction require animals to make critical decisions amidst a naturally dynamic environmental and social background (i.e. "context"). However, human activities have pervasively, and rapidly, extended contextual variation into evolutionarily novel territory, potentially rendering evolved animal decision-making mechanisms and strategies maladaptive. We suggest that explicitly focusing on animal decision-making (ADM), by integrating and applying findings from studies of sensory ecology, cognitive psychology, behavioral economics and eco-evolutionary strategies, may enhance our understanding of, and our ability to predict how, human-driven changes in the environment and population demography will influence animal populations. Fundamentally, the decisions animals make involve evolved mechanisms, and behaviors emerge from the combined action of sensory integration, cognitive mechanisms and strategic rules of thumb, and any of these processes may have a disproportionate influence on behavior. Although there is extensive literature exploring ADM, it generally reflects a canalized, discipline-specific approach that lacks a unified conceptual framework. As a result, there has been limited application of ADM theory and research findings into predictive models that can enhance management outcomes, even though it is likely that the relative resilience of species to rapid environmental change is fundamentally a result of how ADM is linked to contextual variation. Here, we focus on how context influences ADM, and highlight ideas and results that may be most applicable to conservation biology. © 2016 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

Mobile Phones Democratize and Cultivate Next-Generation Imaging, Diagnostics and Measurement Tools

PubMed Central

Ozcan, Aydogan

2014-01-01

In this article, I discuss some of the emerging applications and the future opportunities and challenges created by the use of mobile phones and their embedded components for the development of next-generation imaging, sensing, diagnostics and measurement tools. The massive volume of mobile phone users, which has now reached ~7 billion, drives the rapid improvements of the hardware, software and high-end imaging and sensing technologies embedded in our phones, transforming the mobile phone into a cost-effective and yet extremely powerful platform to run e.g., biomedical tests and perform scientific measurements that would normally require advanced laboratory instruments. This rapidly evolving and continuing trend will help us transform how medicine, engineering and sciences are practiced and taught globally. PMID:24647550

Evolutionary rewiring of bacterial regulatory networks

PubMed Central

Taylor, Tiffany B.; Mulley, Geraldine; McGuffin, Liam J.; Johnson, Louise J.; Brockhurst, Michael A.; Arseneault, Tanya; Silby, Mark W.; Jackson, Robert W.

2015-01-01

Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks - homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs. PMID:28357301

A history of forensic anthropology.

PubMed

Ubelaker, Douglas H

2018-04-01

Forensic anthropology represents a dynamic and rapidly evolving complex discipline within anthropology and forensic science. Academic roots extend back to early European anatomists but development coalesced in the Americas through high-profile court testimony, assemblage of documented collections and focused research. Formation of the anthropology section of the American Academy of Forensic Sciences in 1972, the American Board of Forensic Anthropology in 1977/1978 and other organizational advances provided important stimuli for progress. While early pioneers concentrated on analysis of skeletonized human remains, applications today have expanded to include complex methods of search and recovery, the biomechanics of trauma interpretation, isotopic analysis related to diet and region of origin, age estimation of the living and issues related to humanitarian and human rights investigations. © 2018 Wiley Periodicals, Inc.

MD-CTS: An integrated terminology reference of clinical and translational medicine.

PubMed

Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A; Weichelt, Bryan; Lin, Simon M

2016-01-01

New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference-Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95%) than paper-based dictionaries (57-71%).

Large-Scale 3D Printing: The Way Forward

NASA Astrophysics Data System (ADS)

Jassmi, Hamad Al; Najjar, Fady Al; Ismail Mourad, Abdel-Hamid

2018-03-01

Research on small-scale 3D printing has rapidly evolved, where numerous industrial products have been tested and successfully applied. Nonetheless, research on large-scale 3D printing, directed to large-scale applications such as construction and automotive manufacturing, yet demands a great a great deal of efforts. Large-scale 3D printing is considered an interdisciplinary topic and requires establishing a blended knowledge base from numerous research fields including structural engineering, materials science, mechatronics, software engineering, artificial intelligence and architectural engineering. This review article summarizes key topics of relevance to new research trends on large-scale 3D printing, particularly pertaining (1) technological solutions of additive construction (i.e. the 3D printers themselves), (2) materials science challenges, and (3) new design opportunities.

Space Missions Trade Space Generation and Assessment Using JPL Rapid Mission Architecture (RMA) Team Approach

NASA Technical Reports Server (NTRS)

Moeller, Robert C.; Borden, Chester; Spilker, Thomas; Smythe, William; Lock, Robert

2011-01-01

The JPL Rapid Mission Architecture (RMA) capability is a novel collaborative team-based approach to generate new mission architectures, explore broad trade space options, and conduct architecture-level analyses. RMA studies address feasibility and identify best candidates to proceed to further detailed design studies. Development of RMA first began at JPL in 2007 and has evolved to address the need for rapid, effective early mission architectural development and trade space exploration as a precursor to traditional point design evaluations. The RMA approach integrates a small team of architecture-level experts (typically 6-10 people) to generate and explore a wide-ranging trade space of mission architectures driven by the mission science (or technology) objectives. Group brainstorming and trade space analyses are conducted at a higher level of assessment across multiple mission architectures and systems to enable rapid assessment of a set of diverse, innovative concepts. This paper describes the overall JPL RMA team, process, and high-level approach. Some illustrative results from previous JPL RMA studies are discussed.

Enabling Technologies for the Future of Chemical Synthesis.

PubMed

Fitzpatrick, Daniel E; Battilocchio, Claudio; Ley, Steven V

2016-03-23

Technology is evolving at breakneck pace, changing the way we communicate, travel, find out information, and live our lives. Yet chemistry as a science has been slower to adapt to this rapidly shifting world. In this Outlook we use highlights from recent literature reports to describe how progresses in enabling technologies are altering this trend, permitting chemists to incorporate new advances into their work at all levels of the chemistry development cycle. We discuss the benefits and challenges that have arisen, impacts on academic-industry relationships, and future trends in the area of chemical synthesis.

Defining core elements and outstanding practice in Nutritional Science through collaborative benchmarking.

PubMed

Samman, Samir; McCarthur, Jennifer O; Peat, Mary

2006-01-01

Benchmarking has been adopted by educational institutions as a potentially sensitive tool for improving learning and teaching. To date there has been limited application of benchmarking methodology in the Discipline of Nutritional Science. The aim of this survey was to define core elements and outstanding practice in Nutritional Science through collaborative benchmarking. Questionnaires that aimed to establish proposed core elements for Nutritional Science, and inquired about definitions of " good" and " outstanding" practice were posted to named representatives at eight Australian universities. Seven respondents identified core elements that included knowledge of nutrient metabolism and requirement, food production and processing, modern biomedical techniques that could be applied to understanding nutrition, and social and environmental issues as related to Nutritional Science. Four of the eight institutions who agreed to participate in the present survey identified the integration of teaching with research as an indicator of outstanding practice. Nutritional Science is a rapidly evolving discipline. Further and more comprehensive surveys are required to consolidate and update the definition of the discipline, and to identify the optimal way of teaching it. Global ideas and specific regional requirements also need to be considered.

Tracking the NGS revolution: managing life science research on shared high-performance computing clusters.

PubMed

Dahlö, Martin; Scofield, Douglas G; Schaal, Wesley; Spjuth, Ola

2018-05-01

Next-generation sequencing (NGS) has transformed the life sciences, and many research groups are newly dependent upon computer clusters to store and analyze large datasets. This creates challenges for e-infrastructures accustomed to hosting computationally mature research in other sciences. Using data gathered from our own clusters at UPPMAX computing center at Uppsala University, Sweden, where core hour usage of ∼800 NGS and ∼200 non-NGS projects is now similar, we compare and contrast the growth, administrative burden, and cluster usage of NGS projects with projects from other sciences. The number of NGS projects has grown rapidly since 2010, with growth driven by entry of new research groups. Storage used by NGS projects has grown more rapidly since 2013 and is now limited by disk capacity. NGS users submit nearly twice as many support tickets per user, and 11 more tools are installed each month for NGS projects than for non-NGS projects. We developed usage and efficiency metrics and show that computing jobs for NGS projects use more RAM than non-NGS projects, are more variable in core usage, and rarely span multiple nodes. NGS jobs use booked resources less efficiently for a variety of reasons. Active monitoring can improve this somewhat. Hosting NGS projects imposes a large administrative burden at UPPMAX due to large numbers of inexperienced users and diverse and rapidly evolving research areas. We provide a set of recommendations for e-infrastructures that host NGS research projects. We provide anonymized versions of our storage, job, and efficiency databases.

Tracking the NGS revolution: managing life science research on shared high-performance computing clusters

PubMed Central

2018-01-01

Abstract Background Next-generation sequencing (NGS) has transformed the life sciences, and many research groups are newly dependent upon computer clusters to store and analyze large datasets. This creates challenges for e-infrastructures accustomed to hosting computationally mature research in other sciences. Using data gathered from our own clusters at UPPMAX computing center at Uppsala University, Sweden, where core hour usage of ∼800 NGS and ∼200 non-NGS projects is now similar, we compare and contrast the growth, administrative burden, and cluster usage of NGS projects with projects from other sciences. Results The number of NGS projects has grown rapidly since 2010, with growth driven by entry of new research groups. Storage used by NGS projects has grown more rapidly since 2013 and is now limited by disk capacity. NGS users submit nearly twice as many support tickets per user, and 11 more tools are installed each month for NGS projects than for non-NGS projects. We developed usage and efficiency metrics and show that computing jobs for NGS projects use more RAM than non-NGS projects, are more variable in core usage, and rarely span multiple nodes. NGS jobs use booked resources less efficiently for a variety of reasons. Active monitoring can improve this somewhat. Conclusions Hosting NGS projects imposes a large administrative burden at UPPMAX due to large numbers of inexperienced users and diverse and rapidly evolving research areas. We provide a set of recommendations for e-infrastructures that host NGS research projects. We provide anonymized versions of our storage, job, and efficiency databases. PMID:29659792

Grip on health: A complex systems approach to transform health care.

PubMed

van Wietmarschen, Herman A; Wortelboer, Heleen M; van der Greef, Jan

2018-02-01

This article addresses the urgent need for a transition in health care to deal with the increasing prevalence of chronic diseases and associated rapid rise of health care costs. Chronic diseases evolve and are predominantly related to lifestyle and environment. A shift is needed from a reductionist repair mode of thinking, toward a more integrated biopsychosocial way of thinking about health. The aim of this article is to discuss the opportunities that complexity science offer for transforming health care toward optimal treatment and prevention of chronic lifestyle diseases. Health and health care is discussed from a complexity science perspective. The benefits of concepts developed in the field of complexity science for stimulating transitions in health care are explored. Complexity science supports the elucidation of the essence of health processes. It provides a unique perspective on health with a focus on the relationships within networks of dynamically interacting factors and the emergence of health out of the organization of those relationships. Novel types of complexity science-based intervention strategies are being developed. The first application in practice is the integrated obesity treatment program currently piloted in the Netherlands, focusing on health awareness and healing relationships. Complexity science offers various theories and methods to capture the path toward unhealthy and healthy states, facilitating the development of a dynamic integrated biopsychosocial perspective on health. This perspective offers unique insights into health processes for patients and citizens. In addition, dynamic models driven by personal data provide simulations of health processes and the ability to detect transitions between health states. Such models are essential for aligning and reconnecting the many institutions and disciplines involved in the health care sector and evolve toward an integrated health care ecosystem. © 2016 John Wiley & Sons, Ltd.

Estimating phylogenetic trees from genome-scale data.

PubMed

Liu, Liang; Xi, Zhenxiang; Wu, Shaoyuan; Davis, Charles C; Edwards, Scott V

2015-12-01

The heterogeneity of signals in the genomes of diverse organisms poses challenges for traditional phylogenetic analysis. Phylogenetic methods known as "species tree" methods have been proposed to directly address one important source of gene tree heterogeneity, namely the incomplete lineage sorting that occurs when evolving lineages radiate rapidly, resulting in a diversity of gene trees from a single underlying species tree. Here we review theory and empirical examples that help clarify conflicts between species tree and concatenation methods, and misconceptions in the literature about the performance of species tree methods. Considering concatenation as a special case of the multispecies coalescent model helps explain differences in the behavior of the two methods on phylogenomic data sets. Recent work suggests that species tree methods are more robust than concatenation approaches to some of the classic challenges of phylogenetic analysis, including rapidly evolving sites in DNA sequences and long-branch attraction. We show that approaches, such as binning, designed to augment the signal in species tree analyses can distort the distribution of gene trees and are inconsistent. Computationally efficient species tree methods incorporating biological realism are a key to phylogenetic analysis of whole-genome data. © 2015 New York Academy of Sciences.

Thermodynamic forces in coarse-grained simulations

NASA Astrophysics Data System (ADS)

Noid, William

Atomically detailed molecular dynamics simulations have profoundly advanced our understanding of the structure and interactions in soft condensed phases. Nevertheless, despite dramatic advances in the methodology and resources for simulating atomically detailed models, low-resolution coarse-grained (CG) models play a central and rapidly growing role in science. CG models not only empower researchers to investigate phenomena beyond the scope of atomically detailed simulations, but also to precisely tailor models for specific phenomena. However, in contrast to atomically detailed simulations, which evolve on a potential energy surface, CG simulations should evolve on a free energy surface. Therefore, the forces in CG models should reflect the thermodynamic information that has been eliminated from the CG configuration space. As a consequence of these thermodynamic forces, CG models often demonstrate limited transferability and, moreover, rarely provide an accurate description of both structural and thermodynamic properties. In this talk, I will present a framework that clarifies the origin and impact of these thermodynamic forces. Additionally, I will present computational methods for quantifying these forces and incorporating their effects into CG MD simulations. As time allows, I will demonstrate applications of this framework for liquids, polymers, and interfaces. We gratefully acknowledge the support of the National Science Foundation via CHE 1565631.

Modeling Co-evolution of Speech and Biology.

PubMed

de Boer, Bart

2016-04-01

Two computer simulations are investigated that model interaction of cultural evolution of language and biological evolution of adaptations to language. Both are agent-based models in which a population of agents imitates each other using realistic vowels. The agents evolve under selective pressure for good imitation. In one model, the evolution of the vocal tract is modeled; in the other, a cognitive mechanism for perceiving speech accurately is modeled. In both cases, biological adaptations to using and learning speech evolve, even though the system of speech sounds itself changes at a more rapid time scale than biological evolution. However, the fact that the available acoustic space is used maximally (a self-organized result of cultural evolution) is constant, and therefore biological evolution does have a stable target. This work shows that when cultural and biological traits are continuous, their co-evolution may lead to cognitive adaptations that are strong enough to detect empirically. Copyright © 2016 Cognitive Science Society, Inc.

Biomimetic molecular design tools that learn, evolve, and adapt.

PubMed

Winkler, David A

2017-01-01

A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known "S curve", with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine.

Biomimetic molecular design tools that learn, evolve, and adapt

PubMed Central

2017-01-01

A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known “S curve”, with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine. PMID:28694872

Evaluation of Big Data Containers for Popular Storage, Retrieval, and Computation Primitives in Earth Science Analysis

NASA Astrophysics Data System (ADS)

Das, K.; Clune, T.; Kuo, K. S.; Mattmann, C. A.; Huang, T.; Duffy, D.; Yang, C. P.; Habermann, T.

2015-12-01

Data containers are infrastructures that facilitate storage, retrieval, and analysis of data sets. Big data applications in Earth Science require a mix of processing techniques, data sources and storage formats that are supported by different data containers. Some of the most popular data containers used in Earth Science studies are Hadoop, Spark, SciDB, AsterixDB, and RasDaMan. These containers optimize different aspects of the data processing pipeline and are, therefore, suitable for different types of applications. These containers are expected to undergo rapid evolution and the ability to re-test, as they evolve, is very important to ensure the containers are up to date and ready to be deployed to handle large volumes of observational data and model output. Our goal is to develop an evaluation plan for these containers to assess their suitability for Earth Science data processing needs. We have identified a selection of test cases that are relevant to most data processing exercises in Earth Science applications and we aim to evaluate these systems for optimal performance against each of these test cases. The use cases identified as part of this study are (i) data fetching, (ii) data preparation for multivariate analysis, (iii) data normalization, (iv) distance (kernel) computation, and (v) optimization. In this study we develop a set of metrics for performance evaluation, define the specifics of governance, and test the plan on current versions of the data containers. The test plan and the design mechanism are expandable to allow repeated testing with both new containers and upgraded versions of the ones mentioned above, so that we can gauge their utility as they evolve.

Enabling Technologies for the Future of Chemical Synthesis

PubMed Central

2016-01-01

Technology is evolving at breakneck pace, changing the way we communicate, travel, find out information, and live our lives. Yet chemistry as a science has been slower to adapt to this rapidly shifting world. In this Outlook we use highlights from recent literature reports to describe how progresses in enabling technologies are altering this trend, permitting chemists to incorporate new advances into their work at all levels of the chemistry development cycle. We discuss the benefits and challenges that have arisen, impacts on academic–industry relationships, and future trends in the area of chemical synthesis. PMID:27163040

Cardiac Arrest Resuscitation.

PubMed

Guyette, Francis X; Reynolds, Joshua C; Frisch, Adam

2015-08-01

Cardiac arrest is a dynamic disease that tests the multitasking and leadership abilities of emergency physicians. Providers must simultaneously manage the logistics of resuscitation while searching for the cause of cardiac arrest. The astute clinician will also realize that he or she is orchestrating only one portion of a larger series of events, each of which directly affects patient outcomes. Resuscitation science is rapidly evolving, and emergency providers must be familiar with the latest evidence and controversies surrounding resuscitative techniques. This article reviews evidence, discusses controversies, and offers strategies to provide quality cardiac arrest resuscitation. Copyright © 2015 Elsevier Inc. All rights reserved.

Building an Effective Social Media Strategy for Science Programs

NASA Astrophysics Data System (ADS)

Bohon, Wendy; Robinson, Sarah; Arrowsmith, Ramon; Semken, Steven

2013-07-01

Social media has emerged as a popular mode of communication, with more than 73% of the teenage and adult population in the United States using it on a regular basis [Lenhart et al., 2010]. Young people in particular (ages 12-29) are deeply involved in the rapidly evolving social media environment and have an expectation of communication through these media. This engagement creates a valuable opportunity for scientific organizations and programs to use the wide reach, functionality, and informal environment of social media to create brand recognition, establish trust with users, and disseminate scientific information.

The impact of rapid evolution on population dynamics in the wild: experimental test of eco-evolutionary dynamics.

PubMed

Turcotte, Martin M; Reznick, David N; Hare, J Daniel

2011-11-01

Rapid evolution challenges the assumption that evolution is too slow to impact short-term ecological dynamics. This insight motivates the study of 'Eco-Evolutionary Dynamics' or how evolution and ecological processes reciprocally interact on short time scales. We tested how rapid evolution impacts concurrent population dynamics using an aphid (Myzus persicae) and an undomesticated host (Hirschfeldia incana) in replicated wild populations. We manipulated evolvability by creating non-evolving (single clone) and potentially evolving (two-clone) aphid populations that contained genetic variation in intrinsic growth rate. We observed significant evolution in two-clone populations whether or not they were exposed to predators and competitors. Evolving populations grew up to 42% faster and attained up to 67% higher density, compared with non-evolving control populations but only in treatments exposed to competitors and predators. Increased density also correlates with relative fitness of competing clones suggesting a full eco-evolutionary dynamic cycle defined as reciprocal interactions between evolution and density. © 2011 Blackwell Publishing Ltd/CNRS.

ECHO Responds to NASA's Earth Science User Community

NASA Technical Reports Server (NTRS)

Pfister, Robin; Ullman, Richard; Wichmann, Keith; Perkins, Dorothy C. (Technical Monitor)

2001-01-01

Over the past decade NASA has designed, built, evolved, and operated the Earth Observing System Data and Information System (EOSDIS) Information Management System (IMS) in order to provide user access to NASA's Earth Science data holdings. During this time revolutionary advances in technology have driven changes in NASA's approach to providing an IMS service. This paper will describe NASA's strategic planning and approach to build and evolve the EOSDIS IMS and to serve the evolving needs of NASA's Earth Science community. It discusses the original strategic plan and how lessons learned help to form a new plan, a new approach and a new system. It discusses the original technologies and how they have evolved to today.

Computed tomography imaging spectrometer (CTIS) with 2D reflective grating for ultraviolet to long-wave infrared detection especially useful for surveying transient events

NASA Technical Reports Server (NTRS)

Muller, Richard E. (Inventor); Mouroulis, Pantazis Z. (Inventor); Maker, Paul D. (Inventor); Wilson, Daniel W. (Inventor)

2003-01-01

The optical system of this invention is an unique type of imaging spectrometer, i.e. an instrument that can determine the spectra of all points in a two-dimensional scene. The general type of imaging spectrometer under which this invention falls has been termed a computed-tomography imaging spectrometer (CTIS). CTIS's have the ability to perform spectral imaging of scenes containing rapidly moving objects or evolving features, hereafter referred to as transient scenes. This invention, a reflective CTIS with an unique two-dimensional reflective grating, can operate in any wavelength band from the ultraviolet through long-wave infrared. Although this spectrometer is especially useful for rapidly occurring events it is also useful for investigation of some slow moving phenomena as in the life sciences.

Avionics and Power Management for Low-Cost High-Altitude Balloon Science Platforms

NASA Technical Reports Server (NTRS)

Chin, Jeffrey; Roberts, Anthony; McNatt, Jeremiah

2016-01-01

High-altitude balloons (HABs) have become popular as educational and scientific platforms for planetary research. This document outlines key components for missions where low cost and rapid development are desired. As an alternative to ground-based vacuum and thermal testing, these systems can be flight tested at comparable costs. Communication, solar, space, and atmospheric sensing experiments often require environments where ground level testing can be challenging or impossible in certain cases. When performing HAB research the ability to monitor the status of the platform and gather data is key for both scientific and recoverability aspects of the mission. A few turnkey platform solutions are outlined that leverage rapidly evolving open-source engineering ecosystems. Rather than building custom components from scratch, these recommendations attempt to maximize simplicity and cost of HAB platforms to make launches more accessible to everyone.

Anesthesiology and competitive strategy.

PubMed

Gross, Wendy L; Gold, Barbara

2009-03-01

Whether we like it or not, medicine is big business. The argument is sometimes made that standard management strategies from the business world do not apply to medicine because the economics and practice of medicine are unique--driven by science and rapid rates of change. But an exploding knowledge base, light-speed technological development, and ever-changing reimbursement schemes are not exclusive to medicine and health care. Some fundamental principles of finance, business management, and strategic development have evolved to deal with problems of rapid change. These principles do apply to modern medicine. The business side of anesthesia practice is off-putting to many clinicians. However, knowledge of the market forces at play can help enhance patient care, improve service, expand opportunities, and extend the perimeter of the discipline. The mission and current market position of anesthesiology practice are considered here.

Vodcasting for Everyone

NASA Astrophysics Data System (ADS)

Hurt, R.; Christensen, L. L.

2008-06-01

Video podcasting, or vodcasting, is the latest evolution of the podcast revolution. The market for on-demand content spans the gamut, ranging from portable media players to computers, and increasingly to televisions through home media centers. This new mode of accessing video content is rapidly growing in popularity, particularly among younger audiences. Because it allows a direct link between consumer and content producer, bypassing traditional media networks, it is ideal for EPO efforts. Even modest budgets can yield compelling astronomy vodcasts that will appeal to a large audience. Gateways like the iTunes Music Store and YouTube have created new content markets where none existed before. This paper highlights the key steps for producing a vodcast. The reader will see how to make (or improve) a video podcast for science communication purposes learn about some of the latest developments in this rapidly-evolving field.

Vodcasting for Everyone

NASA Astrophysics Data System (ADS)

Christensen, L. L.; Hurt, R. L.

2008-06-01

Video podcasting, or vodcasting, is the latest evolution of the podcast revolution. The market for on-demand content spans the gamut, ranging from portable media players to computers, and increasingly to televisions through home media centres. This new mode of accessing video content is rapidly growing in popularity, particularly among younger audiences. Because it allows a direct link between consumer and content producer, bypassing traditional media networks, it is ideal for EPO efforts. Even modest budgets can yield compelling astronomy vodcasts that will appeal to a large audience. Gateways like the iTunes Music Store and YouTube have created new content markets where none existed before. This paper highlights the key steps for producing a vodcast. The reader will see how to make (or improve) a video podcast for science communication purposes learn about some of the latest developments in this rapidly-evolving field.

Epistemological Dialogue of Validity: Building Validity in Educational and Social Research

ERIC Educational Resources Information Center

Cakir, Mustafa

2012-01-01

The notion of validity in the social sciences is evolving and is influenced by philosophy of science, critiques of objectivity, and epistemological debates. Methodology for validation of the knowledge claims is diverse across different philosophies of science. In other words, definition and the way to establish of validity have evolved as…

Controlled droplet microfluidic systems for multistep chemical and biological assays.

PubMed

Kaminski, T S; Garstecki, P

2017-10-16

Droplet microfluidics is a relatively new and rapidly evolving field of science focused on studying the hydrodynamics and properties of biphasic flows at the microscale, and on the development of systems for practical applications in chemistry, biology and materials science. Microdroplets present several unique characteristics of interest to a broader research community. The main distinguishing features include (i) large numbers of isolated compartments of tiny volumes that are ideal for single cell or single molecule assays, (ii) rapid mixing and negligible thermal inertia that all provide excellent control over reaction conditions, and (iii) the presence of two immiscible liquids and the interface between them that enables new or exotic processes (the synthesis of new functional materials and structures that are otherwise difficult to obtain, studies of the functions and properties of lipid and polymer membranes and execution of reactions at liquid-liquid interfaces). The most frequent application of droplet microfluidics relies on the generation of large numbers of compartments either for ultrahigh throughput screens or for the synthesis of functional materials composed of millions of droplets or particles. Droplet microfluidics has already evolved into a complex field. In this review we focus on 'controlled droplet microfluidics' - a portfolio of techniques that provide convenient platforms for multistep complex reaction protocols and that take advantage of automated and passive methods of fluid handling on a chip. 'Controlled droplet microfluidics' can be regarded as a group of methods capable of addressing and manipulating droplets in series. The functionality and complexity of controlled droplet microfluidic systems can be positioned between digital microfluidics (DMF) addressing each droplet individually using 2D arrays of electrodes and ultrahigh throughput droplet microfluidics focused on the generation of hundreds of thousands or even millions of picoliter droplets that cannot be individually addressed by their location on a chip.

Patient with rapidly evolving neurological disease with neuropathological lesions of Creutzfeldt-Jakob disease, Lewy body dementia, chronic subcortical vascular encephalopathy and meningothelial meningioma.

PubMed

Vita, Maria Gabriella; Tiple, Dorina; Bizzarro, Alessandra; Ladogana, Anna; Colaizzo, Elisa; Capellari, Sabina; Rossi, Marcello; Parchi, Piero; Masullo, Carlo; Pocchiari, Maurizio

2017-04-01

We report a case of rapidly evolving neurological disease in a patient with neuropathological lesions of Creutzfeldt-Jakob disease (CJD), Lewy body dementia (LBD), chronic subcortical vascular encephalopathy and meningothelial meningioma. The coexistence of severe multiple pathologies in a single patient strengthens the need to perform accurate clinical differential diagnoses in rapidly progressive dementias. © 2016 Japanese Society of Neuropathology.

A new course and textbook on Physical Models of Living Systems, for science and engineering undergraduates

NASA Astrophysics Data System (ADS)

Nelson, Philip

2015-03-01

I'll describe an intermediate-level course on ``Physical Models of Living Systems.'' The only prerequisite is first-year university physics and calculus. The course is a response to rapidly growing interest among undergraduates in a broad range of science and engineering majors. Students acquire several research skills that are often not addressed in traditional courses: Basic modeling skills Probabilistic modeling skills Data analysis methods Computer programming using a general-purpose platform like MATLAB or Python Dynamical systems, particularly feedback control. These basic skills, which are relevant to nearly any field of science or engineering, are presented in the context of case studies from living systems, including: Virus dynamics Bacterial genetics and evolution of drug resistance Statistical inference Superresolution microscopy Synthetic biology Naturally evolved cellular circuits. Work supported by NSF Grants EF-0928048 and DMR-0832802.

Middle School Science Teachers' Confidence and Pedagogical Practice of New Literacies

NASA Astrophysics Data System (ADS)

Hsu, Hui-Yin; Wang, Shiang-Kwei; Runco, Lisa

2013-06-01

Due to the rapid advancements of information and communication technologies (ICTs), educational researchers argue that multimodal and new literacies should become common practices in schools. As new ICTs emerge and evolve, students need the new literacies skills and practices to successfully participate fully in the civic life of a global community. Are teachers prepared to integrate ICTs in the classroom to develop students' new literacies skills? The purpose of this study is to suggest a new literacies framework that guides ICTs integration and supports scientific inquiry, as well as investigate middle school teachers' confidence to practice new literacies in science classrooms. The study adopted mixed-methodology design, surveyed 32 middle school science teachers' ICTs and new literacies skills, and randomly observed 15 teachers' new literacies practices in the classrooms. The results revealed that even though teachers have high confidence in using ICTs, the meaningful technology integration and new literacies practices were scarcely observed in their classroom practices.

Book Review: Opening Science, the Evolving Guide on How the Internet is Changing Research, Collaboration, and Scholarly Publishing

EPA Science Inventory

The way we get our funding, collaborate, do our research, and get the word out has evolved over hundreds of years but we can imagine a more open science world, largely facilitated by the internet. The movement towards this more open way of doing and presenting science is coming, ...

Climate in Context - How partnerships evolve in regions

NASA Astrophysics Data System (ADS)

Parris, A. S.

2014-12-01

In 2015, NOAA's RISA program will celebrate its 20th year of exploration in the development of usable climate information. In the mid-1990s, a vision emerged to develop interdisciplinary research efforts at the regional scale for several important reasons. Recognizable climate patterns, such as the El Nino Southern Oscillation (ENSO), emerge at the regional level where our understanding of observations and models coalesce. Critical resources for society are managed in a context of regional systems, such as water supply and human populations. Multiple scales of governance (local, state, and federal) with complex institutional relationships can be examined across a region. Climate information (i.e. data, science, research etc) developed within these contexts has greater potential for use. All of this work rests on a foundation of iterative engagement between scientists and decision makers. Throughout these interactions, RISAs have navigated diverse politics, extreme events and disasters, socio-economic and ecological disruptions, and advances in both science and technology. Our understanding of information needs is evolving into a richer understanding of complex institutional, legal, political, and cultural contexts within which people can use science to make informed decisions. The outcome of RISA work includes both cases where climate information was used in decisions and cases where capacity for using climate information and making climate resilient decisions has increased over time. In addition to balancing supply and demand of scientific information, RISAs are engaged in a social process of reconciling climate information use with important drivers of society. Because partnerships are critical for sustained engagement, and because engagement is critically important to the use of science, the rapid development of new capacity in regionally-based science programs focused on providing climate decision support is both needed and challenging. New actors can bolster existing partnerships, but also impact trust developed through engagement. Examining other partnership-driven science initiatives, such as Digital Coast or NIDIS, can help identify critical elements of governance and network management that could be applied to the regional climate programs.

Evolution of Scholarly Publishing and Library Services in Astronomy Its Impact, Challenges, and Opportunities

NASA Astrophysics Data System (ADS)

Wesley, Hema; Sheshadri, Geetha

2016-10-01

Scholarly publishing and its procedures have evolved rapidly, forcefully, and incredibly. Technical advances in the production and promotion of science content have dramatically augmented the visibility and reach, deepened the impact and intensified the thrust of science journal content. These changes range from checking text on perforated tapes to pit stop; from hot metal types to CTP; and from Gutenberg to colour digital printers. Intrinsic and inextricable to this revolutionary aspect of evolution in scholarly publishing is the evolution of library services in astronomy which catapulted library resources from preprints on shelves to customised digital repositories and from communicating observational data through postal telegrams to Tablets. What impact does this unique blend of revolutionary advances have on science and society, what are the consequent challenges, and what are the opportunities that can metamorphose from challenges inherent in the power and potential of the `published word'? The perspectives expressed in this paper stem from learning experiences of the authors at the Indian Academy of Sciences, publishers of ten science journals including the Journal of Astrophysics and Astronomy, and at the Raman Research Institute Library (in which Astronomy is one of the core subjects for research)

Using Science Data and Models for Space Weather Forecasting - Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Hesse, Michael; Pulkkinen, Antti; Zheng, Yihua; Maddox, Marlo; Berrios, David; Taktakishvili, Sandro; Kuznetsova, Masha; Chulaki, Anna; Lee, Hyesook; Mullinix, Rick;

Predicting adverse hemodynamic events in critically ill patients.

PubMed

Yoon, Joo H; Pinsky, Michael R

2018-06-01

The art of predicting future hemodynamic instability in the critically ill has rapidly become a science with the advent of advanced analytical processed based on computer-driven machine learning techniques. How these methods have progressed beyond severity scoring systems to interface with decision-support is summarized. Data mining of large multidimensional clinical time-series databases using a variety of machine learning tools has led to our ability to identify alert artifact and filter it from bedside alarms, display real-time risk stratification at the bedside to aid in clinical decision-making and predict the subsequent development of cardiorespiratory insufficiency hours before these events occur. This fast evolving filed is primarily limited by linkage of high-quality granular to physiologic rationale across heterogeneous clinical care domains. Using advanced analytic tools to glean knowledge from clinical data streams is rapidly becoming a reality whose clinical impact potential is great.

A Hands-on Guide to Video Podcasting

NASA Astrophysics Data System (ADS)

Christensen, L. L.; Hurt, R.

2008-02-01

Video podcasting, or vodcasting, is the latest evolution of the podcast revolution. The market for on demand multimedia content spans the gamut, ranging from portable media players to computers, and increasingly to televisions through home media centres. This new mode of accessing content is rapidly growing in popularity, particularly among younger audiences. Vodcasting allows a direct link between consumer and content producer, bypassing traditional media networks, making it ideal for EPO efforts. Even modest budgets can yield compelling astronomy vodcasts that will appeal to a large audience. Gateways like the iTunes Store and video community websites such as Veoh and YouTube have created new content markets where none existed before. This paper highlights the key steps for producing a vodcast and shows some statistics from two leading astronomy vodcasts. The reader will see how to make (or improve) a science video podcast and learn about some of the latest developments in this rapidly-evolving field.

A brief history of vaccines: smallpox to the present.

PubMed

Hsu, Jennifer L

2013-01-01

Modern vaccine history began in the late 18th century with the discovery of smallpox immunization by Edward Jenner. This pivotal step led to substantial progress in prevention of infectious diseases with inactivated vaccines for multiple infectious diseases, including typhoid, plague and cholera. Each advance produced significant decreases in infection-associated morbidity and mortality, thus shaping our modem cultures. As knowledge of microbiology and immunology grew through the 20th century, techniques were developed for cell culture of viruses. This allowed for rapid advances in prevention of polio, varicella, influenza and others. Finally, recent research has led to development of alternative vaccine strategies through use of vectored antigens, pathogen subunits (purified proteins or polysaccharides) or genetically engineered antigens. As the science of vaccinology continues to rapidly evolve, knowledge of the past creates added emphasis on the importance of developing safe and effective strategies for infectious disease prevention in the 21st century.

Electricity in the treatment of nervous system disease.

PubMed

Fodstad, H; Hariz, M

2007-01-01

Electricity has been used in medicine for almost two millenniums beginning with electrical chocks from the torpedo fish and ending with the implantation of neuromodulators and neuroprostheses. These implantable stimulators aim to improve functional independence and quality of life in various groups of disabled people. New indications for neuromodulation are still evolving and the field is rapidly advancing. Thanks to modern science and computer technology, electrotherapy has reached a degree of sophistication where it can be applied relatively safely and effectively in a variety of nervous system diseases, including pain, movement disorders, epilepsy, Tourette syndrome, psychiatric disease, addiction, coma, urinary incontinence, impotence, infertility, respiratory paralysis, tinnitus and blindness.

Epigenetics and Therapeutic Targets Mediating Neuroprotection

PubMed Central

Qureshi, Irfan A.; Mehler, Mark F.

2015-01-01

The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses. PMID:26236020

Nursing and genetic biobanks.

PubMed

Sanner, Jennifer E; Yu, Erica; Udtha, Malini; Williams, Pamela Holtzclaw

2013-12-01

Biobanks function as vital components in genetic research, which often requires large disease-based or population-based biospecimens and clinical data to study complex or rare diseases. Genetic biobanks aim to provide resources for translational research focusing on rapidly moving scientific findings from the laboratory into health care practice. The nursing profession must evolve as genetic biobanking practices advance. Nursing involvement in genetic biobanking practices comes with a distinct set of educational, ethical, and practice competencies. In response to these growing competency standards, nursing science developed a conceptual framework and continues to study ethical considerations to guide genetic biobanking initiatives. Copyright © 2013 Elsevier Inc. All rights reserved.

Developing Collective Learning Extension for Rapidly Evolving Information System Courses

ERIC Educational Resources Information Center

Agarwal, Nitin; Ahmed, Faysal

2017-01-01

Due to rapidly evolving Information System (IS) technologies, instructors find themselves stuck in the constant game of catching up. On the same hand students find their skills obsolete almost as soon as they graduate. As part of IS curriculum and education, we need to emphasize more on teaching the students "how to learn" while keeping…

Evolution of Scholarly Publishing and Library Services in Astronomy - Impact, Challenges, and Opportunities

NASA Astrophysics Data System (ADS)

Wesley, Hema; Sheshadri, Geetha

2015-08-01

Science publishing and its procedures have evolved rapidly and incredibly. Technical advances in the production and promotion of science content have dramatically widened the visibility and reach, deepened the impact and intensified the thrust of our journals’ science content. Nevertheless, it is also true that with speed and ease of automation, quality is to be ferociously guarded. Could traditional methods when juxtaposed with the continuous onslaught of newer technologies, in our publishing procedures, be the answer. Are people still the quintessential element in technology?Why do we publish; the phrase “Publish or Perish” has itself, interestingly, evolved in its meaning. How have publishing procedures evolved through the years; what is the impact of these developments; what are the challenges and opportunities for scholarly publishers in this digital age. How do we cope with and preempt the abuse and distortion of internet data, and with unethical practices that threaten to cripple the peer review system, and jeopardize publishing ethics and academic integrity. How can publishers fulfill their responsibility to publish content that is explicitly original.With increasing demand from the astronomical community for e-journals and other e-resources and with the gradual loss of value for printed journals, librarians are developing and maintaining e-libraries and providing access to digital resources, and re-engineering their roles to provide advancing tools for e-pub content.How can we prepare for the future of publishing, or is it already here with the popularity of pre-print servers. How have publishers responded to the Open Access model while being aware that ‘the price of keeping something free comes with a cost’. Will potential authors be confused with identifying traditional peer reviewed content, the predatory journals, the fake reviewers, placing research in institutional repositories, copyright and licenses. Are libraries impacted by these developments in their journal pricing schemes.

The PACA Project: When Amateur Astronomers Become Citizen Scientists

NASA Astrophysics Data System (ADS)

Yanamandra-Fisher, P. A.

2014-12-01

The Pro-Am Collaborative Astronomy (PACA) project evolved from the observational campaign of C/2012 S1 or C/ISON in 2013. Following the success of the professional-amateur astronomer collaboration in scientific research via social media, it is now implemented in other comet observing campaigns. While PACA identifies a consistent collaborative approach to pro-am collaborations, given the volume of data generated for each campaign, new ways of rapid data analysis, mining access and storage are needed. Several interesting results emerged from the synergistic inclusion of both social media and amateur astronomers: (1) the establishment of a network of astronomers and related professionals, that can be galvanized into action on short notice to support observing campaigns; (2) assist in various science investigations pertinent to the campaign; (3) provide an alert-sounding mechanism should the need arise; (4) immediate outreach and dissemination of results via our media/blogger members; (5) provide a forum for discussions between the imagers and modelers to help strategize the observing campaign for maximum benefit. In 2014, two new comet observing campaigns involving pro-am collaborations have been initiated: (1) C/2013 A1 (C/SidingSpring) and (2) 67P/Churyumov-Gerasimenko (CG), target for ESA/Rosetta mission. The evolving need for individual customized observing campaigns has been incorporated into the evolution of PACA portal that currently is focused on comets: from supporting observing campaigns of current comets, legacy data, historical comets; interconnected with social media and a set of shareable documents addressing observational strategies; consistent standards for data; data access, use, and storage, to align with the needs of professional observers. The integration of science, observations by professional and amateur astronomers, and various social media provides a dynamic and evolving collaborative partnership between professional and amateur astronomers. The empowerment of amateur astronomers vis-à-vis their partnerships with the professional scientists creates a new demographic of data scientists, enabling citizen science of the integrated data from both the professional and amateur communities.

[Surgical laboratory in pregraduate medicine.

PubMed

Tapia-Jurado, Jesús

2011-01-01

Surgical laboratory in pregraduate students in medicine is beneficial and improves learning processes in cognitive aspects and skills acquisition. It is also an early initiation into scientific research. The laboratory is the introductory pathway into basic concepts of medical science (meaningful learning). It is also where students gain knowledge in procedures and abilities to obtain professional skills, an interactive teacher-student process. Medicine works rapidly to change from an art to a science. This fact compromises all schools and medical faculties to analyze their actual lesson plans. Simulators give students confidence and ability and save time, money and resources, eliminating at the same time the ethical factor of using live animals and the fear of patient safety. Multimedia programs may give a cognitive context evolving logically with an explanation based on written and visual animation followed by a clinical problem and its demonstration in a simulator, all before applying knowledge to the patient.

An undergraduate course, and new textbook, on ``Physical Models of Living Systems''

NASA Astrophysics Data System (ADS)

Nelson, Philip

2015-03-01

I'll describe an intermediate-level course on ``Physical Models of Living Systems.'' The only prerequisite is first-year university physics and calculus. The course is a response to rapidly growing interest among undergraduates in several science and engineering departments. Students acquire several research skills that are often not addressed in traditional courses, including: basic modeling skills, probabilistic modeling skills, data analysis methods, computer programming using a general-purpose platform like MATLAB or Python, dynamical systems, particularly feedback control. These basic skills, which are relevant to nearly any field of science or engineering, are presented in the context of case studies from living systems, including: virus dynamics; bacterial genetics and evolution of drug resistance; statistical inference; superresolution microscopy; synthetic biology; naturally evolved cellular circuits. Publication of a new textbook by WH Freeman and Co. is scheduled for December 2014. Supported in part by EF-0928048 and DMR-0832802.

Onboard Radar Processing Development for Rapid Response Applications

NASA Technical Reports Server (NTRS)

Lou, Yunling; Chien, Steve; Clark, Duane; Doubleday, Josh; Muellerschoen, Ron; Wang, Charles C.

2011-01-01

We are developing onboard processor (OBP) technology to streamline data acquisition on-demand and explore the potential of the L-band SAR instrument onboard the proposed DESDynI mission and UAVSAR for rapid response applications. The technology would enable the observation and use of surface change data over rapidly evolving natural hazards, both as an aid to scientific understanding and to provide timely data to agencies responsible for the management and mitigation of natural disasters. We are adapting complex science algorithms for surface water extent to detect flooding, snow/water/ice classification to assist in transportation/ shipping forecasts, and repeat-pass change detection to detect disturbances. We are near completion of the development of a custom FPGA board to meet the specific memory and processing needs of L-band SAR processor algorithms and high speed interfaces to reformat and route raw radar data to/from the FPGA processor board. We have also developed a high fidelity Matlab model of the SAR processor that is modularized and parameterized for ease to prototype various SAR processor algorithms targeted for the FPGA. We will be testing the OBP and rapid response algorithms with UAVSAR data to determine the fidelity of the products.

Collateral damage: rapid exposure-induced evolution of pesticide resistance leads to increased susceptibility to parasites.

PubMed

Jansen, Mieke; Stoks, Robby; Coors, Anja; van Doorslaer, Wendy; de Meester, Luc

2011-09-01

Although natural populations may evolve resistance to anthropogenic stressors such as pollutants, this evolved resistance may carry costs. Using an experimental evolution approach, we exposed different Daphnia magna populations in outdoor containers to the carbamate pesticide carbaryl and control conditions, and assessed the resulting populations for both their resistance to carbaryl as well as their susceptibility to infection by the widespread bacterial microparasite Pasteuria ramosa. Our results show that carbaryl selection led to rapid evolution of carbaryl resistance with seemingly no cost when assessed in a benign environment. However, carbaryl-resistant populations were more susceptible to parasite infection than control populations. Exposure to both stressors reveals a synergistic effect on sterilization rate by P. ramosa, but this synergism did not evolve under pesticide selection. Assessing costs of rapid adaptive evolution to anthropogenic stress in a semi-natural context may be crucial to avoid too optimistic predictions for the fitness of the evolving populations. © 2011 The Author(s).

Applying the Scientific Method of Cybersecurity Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tardiff, Mark F.; Bonheyo, George T.; Cort, Katherine A.

The cyber environment has rapidly evolved from a curiosity to an essential component of the contemporary world. As the cyber environment has expanded and become more complex, so have the nature of adversaries and styles of attacks. Today, cyber incidents are an expected part of life. As a result, cybersecurity research emerged to address adversarial attacks interfering with or preventing normal cyber activities. Historical response to cybersecurity attacks is heavily skewed to tactical responses with an emphasis on rapid recovery. While threat mitigation is important and can be time critical, a knowledge gap exists with respect to developing the sciencemore » of cybersecurity. Such a science will enable the development and testing of theories that lead to understanding the broad sweep of cyber threats and the ability to assess trade-offs in sustaining network missions while mitigating attacks. The Asymmetric Resilient Cybersecurity Initiative at Pacific Northwest National Laboratory is a multi-year, multi-million dollar investment to develop approaches for shifting the advantage to the defender and sustaining the operability of systems under attack. The initiative established a Science Council to focus attention on the research process for cybersecurity. The Council shares science practices, critiques research plans, and aids in documenting and reporting reproducible research results. The Council members represent ecology, economics, statistics, physics, computational chemistry, microbiology and genetics, and geochemistry. This paper reports the initial work of the Science Council to implement the scientific method in cybersecurity research. The second section describes the scientific method. The third section in this paper discusses scientific practices for cybersecurity research. Section four describes initial impacts of applying the science practices to cybersecurity research.« less

Adaptation to fluctuations in temperature by nine species of bacteria.

PubMed

Saarinen, Kati; Laakso, Jouni; Lindström, Leena; Ketola, Tarmo

2018-03-01

Rapid environmental fluctuations are ubiquitous in the wild, yet majority of experimental studies mostly consider effects of slow fluctuations on organism. To test the evolutionary consequences of fast fluctuations, we conducted nine independent experimental evolution experiments with bacteria. Experimental conditions were same for all species, and we allowed them to evolve either in fluctuating temperature alternating rapidly between 20°C and 40°C or at constant 30°C temperature. After experimental evolution, we tested the performance of the clones in both rapid fluctuation and in constant environments (20°C, 30°C and 40°C). Results from experiments on these nine species were combined meta-analytically. We found that overall the clones evolved in the fluctuating environment had evolved better efficiency in tolerating fluctuations (i.e., they had higher yield in fluctuating conditions) than the clones evolved in the constant environment. However, we did not find any evidence that fluctuation-adapted clones would have evolved better tolerance to any measured constant environments (20°C, 30°C, and 40°C). Our results back up recent empirical findings reporting that it is hard to predict adaptations to fast fluctuations using tolerance curves.

ShakeMap manual: technical manual, user's guide, and software guide

USGS Publications Warehouse

Wald, David J.; Worden, Bruce C.; Quitoriano, Vincent; Pankow, Kris L.

2005-01-01

ShakeMap (http://earthquake.usgs.gov/shakemap) --rapidly, automatically generated shaking and intensity maps--combines instrumental measurements of shaking with information about local geology and earthquake location and magnitude to estimate shaking variations throughout a geographic area. The results are rapidly available via the Web through a variety of map formats, including Geographic Information System (GIS) coverages. These maps have become a valuable tool for emergency response, public information, loss estimation, earthquake planning, and post-earthquake engineering and scientific analyses. With the adoption of ShakeMap as a standard tool for a wide array of users and uses came an impressive demand for up-to-date technical documentation and more general guidelines for users and software developers. This manual is meant to address this need. ShakeMap, and associated Web and data products, are rapidly evolving as new advances in communications, earthquake science, and user needs drive improvements. As such, this documentation is organic in nature. We will make every effort to keep it current, but undoubtedly necessary changes in operational systems take precedence over producing and making documentation publishable.

A screen for immunity genes evolving under positive selection in Drosophila.

PubMed

Jiggins, F M; Kim, K W

2007-05-01

Genes involved in the immune system tend to have higher rates of adaptive evolution than other genes in the genome, probably because they are coevolving with pathogens. We have screened a sample of Drosophila genes to identify those evolving under positive selection. First, we identified rapidly evolving immunity genes by comparing 140 loci in Drosophila erecta and D. yakuba. Secondly, we resequenced 23 of the fastest evolving genes from the independent species pair D. melanogaster and D. simulans, and identified those under positive selection using a McDonald-Kreitman test. There was strong evidence of adaptive evolution in two serine proteases (persephone and spirit) and a homolog of the Anopheles serpin SRPN6, and weaker evidence in another serine protease and the death domain protein dFADD. These results add to mounting evidence that immune signalling pathway molecules often evolve rapidly, possibly because they are sites of host-parasite coevolution.

The cancer of bureaucracy: how it will destroy science, medicine, education; and eventually everything else.

PubMed

Charlton, Bruce G

2010-06-01

Everyone living in modernizing 'Western' societies will have noticed the long-term, progressive growth and spread of bureaucracy infiltrating all forms of social organization: nobody loves it, many loathe it, yet it keeps expanding. Such unrelenting growth implies that bureaucracy is parasitic and its growth uncontrollable - in other words it is a cancer that eludes the host immune system. Old-fashioned functional, 'rational' bureaucracy that incorporated individual decision-making is now all-but extinct, rendered obsolete by computerization. But modern bureaucracy evolved from it, the key 'parasitic' mutation being the introduction of committees for major decision-making or decision-ratification. Committees are a fundamentally irrational, incoherent, unpredictable decision-making procedure; which has the twin advantages that it cannot be formalized and replaced by computerization, and that it generates random variation or 'noise' which provides the basis for natural selection processes. Modern bureaucracies have simultaneously grown and spread in a positive feedback cycle; such that interlinking bureaucracies now constitute the major environmental feature of human society which affects organizational survival and reproduction. Individual bureaucracies must become useless parasites which ignore the 'real-world' in order to adapt to rapidly-changing 'bureaucratic reality'. Within science, the major manifestation of bureaucracy is peer review, which - cancer-like - has expanded to obliterate individual authority and autonomy. There has been local elaboration of peer review and metastatic spread of peer review to include all major functions such as admissions, appointments, promotions, grant review, project management, research evaluation, journal and book refereeing and the award of prizes. Peer review eludes the immune system of science since it has now been accepted by other bureaucracies as intrinsically valid, such that any residual individual decision-making (no matter how effective in real-world terms) is regarded as intrinsically unreliable (self-interested and corrupt). Thus the endemic failures of peer review merely trigger demands for ever-more elaborate and widespread peer review. Just as peer review is killing science with its inefficiency and ineffectiveness, so parasitic bureaucracy is an un-containable phenomenon; dangerous to the extent that it cannot be allowed to exist unmolested, but must be utterly extirpated. Or else modernizing societies will themselves be destroyed by sclerosis, resource misallocation, incorrigibly-wrong decisions and the distortions of 'bureaucratic reality'. However, unfortunately, social collapse is the more probable outcome, since parasites can evolve more rapidly than host immune systems.

Arctic Boreal Vulnerability Experiment (ABoVE) Science Cloud

NASA Astrophysics Data System (ADS)

Duffy, D.; Schnase, J. L.; McInerney, M.; Webster, W. P.; Sinno, S.; Thompson, J. H.; Griffith, P. C.; Hoy, E.; Carroll, M.

2014-12-01

The effects of climate change are being revealed at alarming rates in the Arctic and Boreal regions of the planet. NASA's Terrestrial Ecology Program has launched a major field campaign to study these effects over the next 5 to 8 years. The Arctic Boreal Vulnerability Experiment (ABoVE) will challenge scientists to take measurements in the field, study remote observations, and even run models to better understand the impacts of a rapidly changing climate for areas of Alaska and western Canada. The NASA Center for Climate Simulation (NCCS) at the Goddard Space Flight Center (GSFC) has partnered with the Terrestrial Ecology Program to create a science cloud designed for this field campaign - the ABoVE Science Cloud. The cloud combines traditional high performance computing with emerging technologies to create an environment specifically designed for large-scale climate analytics. The ABoVE Science Cloud utilizes (1) virtualized high-speed InfiniBand networks, (2) a combination of high-performance file systems and object storage, and (3) virtual system environments tailored for data intensive, science applications. At the center of the architecture is a large object storage environment, much like a traditional high-performance file system, that supports data proximal processing using technologies like MapReduce on a Hadoop Distributed File System (HDFS). Surrounding the storage is a cloud of high performance compute resources with many processing cores and large memory coupled to the storage through an InfiniBand network. Virtual systems can be tailored to a specific scientist and provisioned on the compute resources with extremely high-speed network connectivity to the storage and to other virtual systems. In this talk, we will present the architectural components of the science cloud and examples of how it is being used to meet the needs of the ABoVE campaign. In our experience, the science cloud approach significantly lowers the barriers and risks to organizations that require high performance computing solutions and provides the NCCS with the agility required to meet our customers' rapidly increasing and evolving requirements.

Nanotechnology in corneal neovascularization therapy--a review.

PubMed

Gonzalez, Lilian; Loza, Raymond J; Han, Kyu-Yeon; Sunoqrot, Suhair; Cunningham, Christy; Purta, Patryk; Drake, James; Jain, Sandeep; Hong, Seungpyo; Chang, Jin-Hong

2013-03-01

Nanotechnology is an up-and-coming branch of science that studies and designs materials with at least one dimension sized from 1-100 nm. These nanomaterials have unique functions at the cellular, atomic, and molecular levels. The term "nanotechnology" was first coined in 1974. Since then, it has evolved dramatically and now consists of distinct and independent scientific fields. Nanotechnology is a highly studied topic of interest, as nanoparticles can be applied to various fields ranging from medicine and pharmacology, to chemistry and agriculture, to environmental science and consumer goods. The rapidly evolving field of nanomedicine incorporates nanotechnology with medical applications, seeking to give rise to new diagnostic means, treatments, and tools. Over the past two decades, numerous studies that underscore the successful fusion of nanotechnology with novel medical applications have emerged. This has given rise to promising new therapies for a variety of diseases, especially cancer. It is becoming abundantly clear that nanotechnology has found a place in the medical field by providing new and more efficient ways to deliver treatment. Ophthalmology can also stand to benefit significantly from the advances in nanotechnology research. As it relates to the eye, research in the nanomedicine field has been particularly focused on developing various treatments to prevent and/or reduce corneal neovascularization among other ophthalmologic disorders. This review article aims to provide an overview of corneal neovascularization, currently available treatments, and where nanotechnology comes into play.

Proceedings from the 2013 Canadian Nutrition Society Conference on Advances in Dietary Fats and Nutrition.

PubMed

Holub, Bruce; Mutch, David M; Pierce, Grant N; Rodriguez-Leyva, Delfin; Aliani, Michel; Innis, Sheila; Yan, William; Lamarche, Benoit; Couture, Patrick; Ma, David W L

2014-07-01

The science of lipid research continues to rapidly evolve and change. New knowledge enhances our understanding and perspectives on the role of lipids in health and nutrition. However, new knowledge also challenges currently held opinions. The following are the proceedings of the 2013 Canadian Nutrition Society Conference on the Advances in Dietary Fats and Nutrition. Content experts presented state-of-the-art information regarding our understanding of fish oil and plant-based n-3 polyunsaturated fatty acids, nutrigenomics, pediatrics, regulatory affairs, and trans fats. These important contributions aim to provide clarity on the latest advances and opinions regarding the role of different types of fats in health.

Boron-selective reactions as powerful tools for modular synthesis of diverse complex molecules.

PubMed

Xu, Liang; Zhang, Shuai; Li, Pengfei

2015-12-21

In the context of modular and rapid construction of molecular diversity and complexity for applications in organic synthesis, biomedical and materials sciences, a generally useful strategy has emerged based on boron-selective chemical transformations. In the last decade, these types of reactions have evolved from proof-of-concept to some advanced applications in the efficient preparation of complex natural products and even automated precise manufacturing on the molecular level. These advances have shown the great potential of boron-selective reactions in simplifying synthetic design and experimental operations, and should inspire new developments in related chemical and technological areas. This tutorial review will highlight the original contributions and representative advances in this emerging field.

Amplify scientific discovery with artificial intelligence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gil, Yolanda; Greaves, Mark T.; Hendler, James

Computing innovations have fundamentally changed many aspects of scientific inquiry. For example, advances in robotics, high-end computing, networking, and databases now underlie much of what we do in science such as gene sequencing, general number crunching, sharing information between scientists, and analyzing large amounts of data. As computing has evolved at a rapid pace, so too has its impact in science, with the most recent computing innovations repeatedly being brought to bear to facilitate new forms of inquiry. Recently, advances in Artificial Intelligence (AI) have deeply penetrated many consumer sectors, including for example Apple’s Siri™ speech recognition system, real-time automatedmore » language translation services, and a new generation of self-driving cars and self-navigating drones. However, AI has yet to achieve comparable levels of penetration in scientific inquiry, despite its tremendous potential in aiding computers to help scientists tackle tasks that require scientific reasoning. We contend that advances in AI will transform the practice of science as we are increasingly able to effectively and jointly harness human and machine intelligence in the pursuit of major scientific challenges.« less

Rapid evolution meets invasive species control: The potential for pesticide resistance in sea lamprey

USGS Publications Warehouse

Dunlop, Erin S.; McLaughlin, Robert L.; Adams, Jean V.; Jones, Michael L.; Birceanu, Oana; Christie, Mark R.; Criger, Lori A.; Hinderer, Julia L.M.; Hollingworth, Robert M.; Johnson, Nicholas; Lantz, Stephen R.; Li, Weiming; Miller, James R.; Morrison, Bruce J.; Mota-Sanchez, David; Muir, Andrew M.; Sepulveda, Maria S.; Steeves, Todd B.; Walter, Lisa; Westman, Erin; Wirgin, Isaac; Wilkie, Michael P.

2018-01-01

Rapid evolution of pest, pathogen and wildlife populations can have undesirable effects; for example, when insects evolve resistance to pesticides or fishes evolve smaller body size in response to harvest. A destructive invasive species in the Laurentian Great Lakes, the sea lamprey (Petromyzon marinus) has been controlled with the pesticide 3-trifluoromethyl-4-nitrophenol (TFM) since the 1950s. We evaluated the likelihood of sea lamprey evolving resistance to TFM by (1) reviewing sea lamprey life history and control; (2) identifying physiological and behavioural resistance strategies; (3) estimating the strength of selection from TFM; (4) assessing the timeline for evolution; and (5) analyzing historical toxicity data for evidence of resistance. The number of sea lamprey generations exposed to TFM was within the range observed for fish populations where rapid evolution has occurred. Mortality from TFM was estimated as 82-90%, suggesting significant selective pressure. However, 57 years of toxicity data revealed no increase in lethal concentrations of TFM. Vigilance and the development of alternative controls are required to prevent this aquatic invasive species from evolving strategies to evade control.

Inheritance of evolved resistance to a novel herbicide (pyroxasulfone).

PubMed

Busi, Roberto; Gaines, Todd A; Vila-Aiub, Martin M; Powles, Stephen B

2014-03-01

Agricultural weeds have rapidly adapted to intensive herbicide selection and resistance to herbicides has evolved within ecological timescales. Yet, the genetic basis of broad-spectrum generalist herbicide resistance is largely unknown. This study aims to determine the genetic control of non-target-site herbicide resistance trait(s) that rapidly evolved under recurrent selection of the novel lipid biosynthesis inhibitor pyroxasulfone in Lolium rigidum. The phenotypic segregation of pyroxasulfone resistance in parental, F1 and back-cross (BC) families was assessed in plants exposed to a gradient of pyroxasulfone doses. The inheritance of resistance to chemically dissimilar herbicides (cross-resistance) was also evaluated. Evolved resistance to the novel selective agent (pyroxasulfone) is explained by Mendelian segregation of one semi-dominant allele incrementally herbicide-selected at higher frequency in the progeny. In BC families, cross-resistance is conferred by an incompletely dominant single major locus. This study confirms that herbicide resistance can rapidly evolve to any novel selective herbicide agents by continuous and repeated herbicide use. The results imply that the combination of herbicide options (rotation, mixtures or combinations) to exploit incomplete dominance can provide acceptable control of broad-spectrum generalist resistance-endowing monogenic traits. Herbicide diversity within a set of integrated management tactics can be one important component to reduce the herbicide selection intensity. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Thinking Through Computational Exposure as an Evolving Paradign Shift for Exposure Science: Development and Application of Predictive Models from Big Data

EPA Science Inventory

Symposium Abstract: Exposure science has evolved from a time when the primary focus was on measurements of environmental and biological media and the development of enabling field and laboratory methods. The Total Exposure Assessment Method (TEAM) studies of the 1980s were class...

Evidence for a high mutation rate at rapidly evolving yeast centromeres.

PubMed

Bensasson, Douda

2011-07-18

Although their role in cell division is essential, centromeres evolve rapidly in animals, plants and yeasts. Unlike the complex centromeres of plants and aminals, the point centromeres of Saccharomcyes yeasts can be readily sequenced to distinguish amongst the possible explanations for fast centromere evolution. Using DNA sequences of all 16 centromeres from 34 strains of Saccharomyces cerevisiae and population genomic data from Saccharomyces paradoxus, I show that centromeres in both species evolve 3 times more rapidly even than selectively unconstrained DNA. Exceptionally high levels of polymorphism seen in multiple yeast populations suggest that rapid centromere evolution does not result from the repeated selective sweeps expected under meiotic drive. I further show that there is little evidence for crossing-over or gene conversion within centromeres, although there is clear evidence for recombination in their immediate vicinity. Finally I show that the mutation spectrum at centromeres is consistent with the pattern of spontaneous mutation elsewhere in the genome. These results indicate that rapid centromere evolution is a common phenomenon in yeast species. Furthermore, these results suggest that rapid centromere evolution does not result from the mutagenic effect of gene conversion, but from a generalised increase in the mutation rate, perhaps arising from the unusual chromatin structure at centromeres in yeast and other eukaryotes.

Evidence for a high mutation rate at rapidly evolving yeast centromeres

PubMed Central

2011-01-01

Background Although their role in cell division is essential, centromeres evolve rapidly in animals, plants and yeasts. Unlike the complex centromeres of plants and aminals, the point centromeres of Saccharomcyes yeasts can be readily sequenced to distinguish amongst the possible explanations for fast centromere evolution. Results Using DNA sequences of all 16 centromeres from 34 strains of Saccharomyces cerevisiae and population genomic data from Saccharomyces paradoxus, I show that centromeres in both species evolve 3 times more rapidly even than selectively unconstrained DNA. Exceptionally high levels of polymorphism seen in multiple yeast populations suggest that rapid centromere evolution does not result from the repeated selective sweeps expected under meiotic drive. I further show that there is little evidence for crossing-over or gene conversion within centromeres, although there is clear evidence for recombination in their immediate vicinity. Finally I show that the mutation spectrum at centromeres is consistent with the pattern of spontaneous mutation elsewhere in the genome. Conclusions These results indicate that rapid centromere evolution is a common phenomenon in yeast species. Furthermore, these results suggest that rapid centromere evolution does not result from the mutagenic effect of gene conversion, but from a generalised increase in the mutation rate, perhaps arising from the unusual chromatin structure at centromeres in yeast and other eukaryotes. PMID:21767380

Nurturing transdisciplinary research - lessons from live experiments in prioritising and supporting novel risk science (Invited)

NASA Astrophysics Data System (ADS)

Rees, J.; Armstrong, C.; Barclay, J.; Moores, A.; Whitaker, D.

2013-12-01

The benefits of specialization over the last 150 years have meant that science has evolved within several distinct disciplines, such as physical, social or environmental. These have generated their own cultures, languages, agendas, institutions, measures of success and cohorts of suitably branded scientists. However, we increasingly see that society and the environment are exposed to many complex, interdependent and rapidly changing risks - not only from natural hazards, but also those associated with fast expanding and ageing populations, highly interconnected and interdependent economies, rapid climate change, and increasingly limited resources. Risks derived from such interacting drivers commonly generate non-linear effects or repercussions and future risks may be very different to those of today; significantly, they span many traditional science disciplines. We thus need to have a fresh look at transdisciplinary risk science, bring in novel ideas and new blood. But what are the best practical ways of sowing the seeds and fertilizing such approaches? The presentation describes novel practical steps to achieve this, all related to building and resourcing transdisciplinary research which incorporates natural hazard science within the UK over the last 5 years. These comprise instruments to prioritise science gaps and provide funding for transdisciplinary research by a) Academic research funders - the Research Councils UK (RCUK) Risk Research Network and current research programmes; b) Government and non-governmental research funders - the Living with Environmental Change Initiative, and the UK Flooding and coastal erosion risk management research strategy - and the UK Collaborative for Development Science sponsored Disasters Research Group; and c) Business funding - through integrated risk modelling for the insurance industry. Whilst young, all these initiatives are healthy and seek to build a portfolio of small scale initiatives that will breed success and develop critical mass. The common threats, such as alienation by conservative philosophies, and stimulants, such as champions who recognise the value of transdisciplinary science, are illustrated and discussed. Given the importance of developing transdisciplinary science the generic lessons from these, and other, ';live experiments' should not be undervalued.

Swiss Experiment: Design, implemention and use of a cross-disciplinary infrastructure for data intensive science

NASA Astrophysics Data System (ADS)

Dawes, N.; Salehi, A.; Clifton, A.; Bavay, M.; Aberer, K.; Parlange, M. B.; Lehning, M.

2010-12-01

It has long been known that environmental processes are cross-disciplinary, but data has continued to be acquired and held for a single purpose. Swiss Experiment is a rapidly evolving cross-disciplinary, distributed sensor data infrastructure, where tools for the environmental science community stem directly from computer science research. The platform uses the bleeding edge of computer science to acquire, store and distribute data and metadata from all environmental science disciplines at a variety of temporal and spatial resolutions. SwissEx is simultaneously developing new technologies to allow low cost, high spatial and temporal resolution measurements such that small areas can be intensely monitored. This data is then combined with existing widespread, low density measurements in the cross-disciplinary platform to provide well documented datasets, which are of use to multiple research disciplines. We present a flexible, generic infrastructure at an advanced stage of development. The infrastructure makes the most of Web 2.0 technologies for a collaborative working environment and as a user interface for a metadata database. This environment is already closely integrated with GSN, an open-source database middleware developed under Swiss Experiment for acquisition and storage of generic time-series data (2D and 3D). GSN can be queried directly by common data processing packages and makes data available in real-time to models and 3rd party software interfaces via its web service interface. It also provides real-time push or pull data exchange between instances, a user management system which leaves data owners in charge of their data, advanced real-time processing and much more. The SwissEx interface is increasingly gaining users and supporting environmental science in Switzerland. It is also an integral part of environmental education projects ClimAtscope and O3E, where the technologies can provide rapid feedback of results for children of all ages and where the data from their own stations can be compared to national data networks.

Adaptive evolution of centromere proteins in plants and animals.

PubMed

Talbert, Paul B; Bryson, Terri D; Henikoff, Steven

2004-01-01

Centromeres represent the last frontiers of plant and animal genomics. Although they perform a conserved function in chromosome segregation, centromeres are typically composed of repetitive satellite sequences that are rapidly evolving. The nucleosomes of centromeres are characterized by a special H3-like histone (CenH3), which evolves rapidly and adaptively in Drosophila and Arabidopsis. Most plant, animal and fungal centromeres also bind a large protein, centromere protein C (CENP-C), that is characterized by a single 24 amino-acid motif (CENPC motif). Whereas we find no evidence that mammalian CenH3 (CENP-A) has been evolving adaptively, mammalian CENP-C proteins contain adaptively evolving regions that overlap with regions of DNA-binding activity. In plants we find that CENP-C proteins have complex duplicated regions, with conserved amino and carboxyl termini that are dissimilar in sequence to their counterparts in animals and fungi. Comparisons of Cenpc genes from Arabidopsis species and from grasses revealed multiple regions that are under positive selection, including duplicated exons in some grasses. In contrast to plants and animals, yeast CENP-C (Mif2p) is under negative selection. CENP-Cs in all plant and animal lineages examined have regions that are rapidly and adaptively evolving. To explain these remarkable evolutionary features for a single-copy gene that is needed at every mitosis, we propose that CENP-Cs, like some CenH3s, suppress meiotic drive of centromeres during female meiosis. This process can account for the rapid evolution and the complexity of centromeric DNA in plants and animals as compared to fungi.

Adaptive evolution of centromere proteins in plants and animals

PubMed Central

Talbert, Paul B; Bryson, Terri D; Henikoff, Steven

2004-01-01

Background Centromeres represent the last frontiers of plant and animal genomics. Although they perform a conserved function in chromosome segregation, centromeres are typically composed of repetitive satellite sequences that are rapidly evolving. The nucleosomes of centromeres are characterized by a special H3-like histone (CenH3), which evolves rapidly and adaptively in Drosophila and Arabidopsis. Most plant, animal and fungal centromeres also bind a large protein, centromere protein C (CENP-C), that is characterized by a single 24 amino-acid motif (CENPC motif). Results Whereas we find no evidence that mammalian CenH3 (CENP-A) has been evolving adaptively, mammalian CENP-C proteins contain adaptively evolving regions that overlap with regions of DNA-binding activity. In plants we find that CENP-C proteins have complex duplicated regions, with conserved amino and carboxyl termini that are dissimilar in sequence to their counterparts in animals and fungi. Comparisons of Cenpc genes from Arabidopsis species and from grasses revealed multiple regions that are under positive selection, including duplicated exons in some grasses. In contrast to plants and animals, yeast CENP-C (Mif2p) is under negative selection. Conclusions CENP-Cs in all plant and animal lineages examined have regions that are rapidly and adaptively evolving. To explain these remarkable evolutionary features for a single-copy gene that is needed at every mitosis, we propose that CENP-Cs, like some CenH3s, suppress meiotic drive of centromeres during female meiosis. This process can account for the rapid evolution and the complexity of centromeric DNA in plants and animals as compared to fungi. PMID:15345035

Living organ donation: an ethical evolution or evolution of ethics?

PubMed

Ghahramani, N

2010-01-01

The disparity between available and needed organs is rapidly increasing, and the number of patients dying while still on the waiting list is growing exponentially. As a partial solution to this disparity, living unrelated transplantation is being performed more frequently, and some have proposed providing financial incentives to donors. The aim of this discussion is to illustrate that with an ever-increasing number of living unrelated transplantations, society and the transplant community should adopt a more active role in developing specific strategies to scrutinize the process. The current paper will also examine the viewpoint that medical ethics is not separable from the prevailing needs of society and involves a constant balancing of often opposing goods. Issues surrounding living unrelated donor transplantation illustrate ethics as a dynamically evolving field, which is often influenced by necessity and which evolves with progression of science and society. As part of this evolution, it is the collective responsibility of society and the transplant community to devise safeguards to guarantee adherence to basic principles of ethics and to avoid "situational ethics."

Tissue Engineering and Regenerative Medicine: Semantic Considerations for an Evolving Paradigm

PubMed Central

Katari, Ravi; Peloso, Andrea; Orlando, Giuseppe

2015-01-01

Tissue engineering (TE) and regenerative medicine (RM) are rapidly evolving fields that are often obscured by a dense cloud of hype and commercialization potential. We find, in the literature and general commentary, that several of the associated terms are casually referenced in varying contexts that ultimately result in the blurring of the distinguishing boundaries which define them. “TE” and “RM” are often used interchangeably, though some experts vehemently argue that they, in fact, represent different conceptual entities. Nevertheless, contemporary scientists have a general idea of the experiments and milestones that can be classified within either or both categories. Given the groundbreaking achievements reported within the past decade and consequent watershed potential of this field, we feel that it would be useful to properly contextualize these terms semantically and historically. In this concept paper, we explore the various definitions proposed in the literature and emphasize that ambiguous terminology can lead to misplaced apprehension. We assert that the central motifs of both concepts have existed within the surgical sciences long before their appearance as terms in the scientific literature. PMID:25629029

Progress in Open-World, Integrative, Collaborative Science Data Platforms (Invited)

NASA Astrophysics Data System (ADS)

Fox, P. A.

2013-12-01

As collaborative, or network science spreads into more Earth and space science fields, both the participants and their funders have expressed a very strong desire for highly functional data and information capabilities that are a) easy to use, b) integrated in a variety of ways, c) leverage prior investments and keep pace with rapid technical change, and d) are not expensive or time-consuming to build or maintain. In response, and based on our accumulated experience over the last decade and a maturing of several key technical approaches, we have adapted, extended, and integrated several open source applications and frameworks that handle major portions of functionality for these platforms. At minimum, these functions include: an object-type repository, collaboration tools, an ability to identify and manage all key entities in the platform, and an integrated portal to manage diverse content and applications, with varied access levels and privacy options. At a conceptual level, science networks (even small ones) deal with people, and many intellectual artifacts produced or consumed in research, organizational and/our outreach activities, as well as the relations among them. Increasingly these networks are modeled as knowledge networks, i.e. graphs with named and typed relations among the 'nodes'. Nodes can be people, organizations, datasets, events, presentations, publications, videos, meetings, reports, groups, and more. In this heterogeneous ecosystem, it is also important to use a set of common informatics approaches to co-design and co-evolve the needed science data platforms based on what real people want to use them for. In this contribution, we present our methods and results for information modeling, adapting, integrating and evolving a networked data science and information architecture based on several open source technologies (Drupal, VIVO, the Comprehensive Knowledge Archive Network; CKAN, and the Global Handle System; GHS). In particular we present both the instantiation of this data platform for the Deep Carbon Observatory, including key functional and non-functional attributes, how the smart mediation among the components is modeled and managed, and discuss its general applicability.

Positioning activated carbon amendment technologies in a novel framework for sediment management.

PubMed

Kupryianchyk, Darya; Rakowska, Magdalena I; Reible, Danny; Harmsen, Joop; Cornelissen, Gerard; van Veggel, Marc; Hale, Sarah E; Grotenhuis, Tim; Koelmans, Albert A

2015-04-01

Contaminated sediments can pose serious threats to human health and the environment by acting as a source of toxic chemicals. The amendment of contaminated sediments with strong sorbents like activated C (AC) is a rapidly developing strategy to manage contaminated sediments. To date, a great deal of attention has been paid to the technical and ecological features and implications of sediment remediation with AC, although science in this field still is rapidly evolving. This article aims to provide an update on the recent literature on these features, and provides a comparison of sediment remediation with AC to other sediment management options, emphasizing their full-scale application. First, a qualitative overview of advantages of current alternatives to remediate contaminated sediments is presented. Subsequently, AC treatment technology is critically reviewed, including current understanding of the effectiveness and ecological safety for the use of AC in natural systems. Finally, this information is used to provide a novel framework for supporting decisions concerning sediment remediation and beneficial reuse. © 2015 SETAC.

Current Rural Drug Use in the US Midwest

PubMed Central

Dombrowski, Kirk; Crawford, Devan; Khan, Bilal; Tyler, Kimberly

2016-01-01

The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While the use of illicit drugs affects every region of the country, most of our current information about drug use comes from large urban areas. Data on rural drug use and its harms justify greater attention. Record overdose rates, unexpected outbreaks of HIV, and a dearth of treatment facilities point to a rapidly worsening health situation. While health sciences have made considerable progress in understanding the etiology of drug use and uncovering the link between drug use and its myriad associated harms, this promising scientific news has not always translated to better health outcomes. The scope of the problem in the Central Plains of the US is growing, and can be estimated from available sources. Clear remedies for this rising level of abuse are available, but few have been implemented. Suggestions for short-term policy remedies are discussed. PMID:27885362

Sensor Webs: Autonomous Rapid Response to Monitor Transient Science Events

NASA Technical Reports Server (NTRS)

Mandl, Dan; Grosvenor, Sandra; Frye, Stu; Sherwood, Robert; Chien, Steve; Davies, Ashley; Cichy, Ben; Ingram, Mary Ann; Langley, John; Miranda, Felix

2005-01-01

To better understand how physical phenomena, such as volcanic eruptions, evolve over time, multiple sensor observations over the duration of the event are required. Using sensor web approaches that integrate original detections by in-situ sensors and global-coverage, lower-resolution, on-orbit assets with automated rapid response observations from high resolution sensors, more observations of significant events can be made with increased temporal, spatial, and spectral resolution. This paper describes experiments using Earth Observing 1 (EO-1) along with other space and ground assets to implement progressive mission autonomy to identify, locate and image with high resolution instruments phenomena such as wildfires, volcanoes, floods and ice breakup. The software that plans, schedules and controls the various satellite assets are used to form ad hoc constellations which enable collaborative autonomous image collections triggered by transient phenomena. This software is both flight and ground based and works in concert to run all of the required assets cohesively and includes software that is model-based, artificial intelligence software.

NASA's Earth Science Data Systems

NASA Technical Reports Server (NTRS)

Ramapriyan, H. K.

2015-01-01

NASA's Earth Science Data Systems (ESDS) Program has evolved over the last two decades, and currently has several core and community components. Core components provide the basic operational capabilities to process, archive, manage and distribute data from NASA missions. Community components provide a path for peer-reviewed research in Earth Science Informatics to feed into the evolution of the core components. The Earth Observing System Data and Information System (EOSDIS) is a core component consisting of twelve Distributed Active Archive Centers (DAACs) and eight Science Investigator-led Processing Systems spread across the U.S. The presentation covers how the ESDS Program continues to evolve and benefits from as well as contributes to advances in Earth Science Informatics.

The 2012 AANS Presidential Address. We are neurosurgery.

PubMed

McCormick, Paul C

2012-12-01

The theme of the 80th Annual Meeting of the American Association of Neurological Surgeons and the title of this presidential address, "We are neurosurgery," is a simple 3-word affirmation of who neurosurgeons are, what they have achieved, and how much there is yet to accomplish. Recent advances in neurobiology and the clinical neurosciences have brought an unprecedented understanding of the human nervous system in both health and disease. As a specialty, neurosurgery has translated knowledge, expanded techniques, and incorporated technology to exponentially expand the science and scope of neurosurgical practice. However, the rapidly advancing, divergently evolving growth of neurosurgery has had profound effects on all aspects of neurosurgery. In this address, the author examines the contemporary meaning of the annual meeting's theme as it relates to the science, practice, specialty, and profession of neurosurgery, as well as the neurosurgeon. In doing so, the author reveals his interpretation of "We are neurosurgery," which he hopes will have an effect on others.

The University of Washington Health Sciences Library BioCommons: an evolving Northwest biomedical research information support infrastructure

PubMed Central

Minie, Mark; Bowers, Stuart; Tarczy-Hornoch, Peter; Roberts, Edward; James, Rose A.; Rambo, Neil; Fuller, Sherrilynne

2006-01-01

Setting: The University of Washington Health Sciences Libraries and Information Center BioCommons serves the bioinformatics needs of researchers at the university and in the vibrant for-profit and not-for-profit biomedical research sector in the Washington area and region. Program Components: The BioCommons comprises services addressing internal University of Washington, not-for-profit, for-profit, and regional and global clientele. The BioCommons is maintained and administered by the BioResearcher Liaison Team. The BioCommons architecture provides a highly flexible structure for adapting to rapidly changing resources and needs. Evaluation Mechanisms: BioCommons uses Web-based pre- and post-course evaluations and periodic user surveys to assess service effectiveness. Recent surveys indicate substantial usage of BioCommons services and a high level of effectiveness and user satisfaction. Next Steps/Future Directions: BioCommons is developing novel collaborative Web resources to distribute bioinformatics tools and is experimenting with Web-based competency training in bioinformation resource use. PMID:16888667

Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease

PubMed Central

Yang, Sihai; Li, Jing; Zhang, Xiaohui; Zhang, Qijun; Huang, Ju; Chen, Jian-Qun; Hartl, Daniel L.; Tian, Dacheng

2013-01-01

We show that the genomes of maize, sorghum, and brachypodium contain genes that, when transformed into rice, confer resistance to rice blast disease. The genes are resistance genes (R genes) that encode proteins with nucleotide-binding site (NBS) and leucine-rich repeat (LRR) domains (NBS–LRR proteins). By using criteria associated with rapid molecular evolution, we identified three rapidly evolving R-gene families in these species as well as in rice, and transformed a randomly chosen subset of these genes into rice strains known to be sensitive to rice blast disease caused by the fungus Magnaporthe oryzae. The transformed strains were then tested for sensitivity or resistance to 12 diverse strains of M. oryzae. A total of 15 functional blast R genes were identified among 60 NBS–LRR genes cloned from maize, sorghum, and brachypodium; and 13 blast R genes were obtained from 20 NBS–LRR paralogs in rice. These results show that abundant blast R genes occur not only within species but also among species, and that the R genes in the same rapidly evolving gene family can exhibit an effector response that confers resistance to rapidly evolving fungal pathogens. Neither conventional evolutionary conservation nor conventional evolutionary convergence supplies a satisfactory explanation of our findings. We suggest a unique mechanism termed “constrained divergence,” in which R genes and pathogen effectors can follow only limited evolutionary pathways to increase fitness. Our results open avenues for R-gene identification that will help to elucidate R-gene vs. effector mechanisms and may yield new sources of durable pathogen resistance. PMID:24145399

Genome-Wide Analysis in Three Fusarium Pathogens Identifies Rapidly Evolving Chromosomes and Genes Associated with Pathogenicity

PubMed Central

Sperschneider, Jana; Gardiner, Donald M.; Thatcher, Louise F.; Lyons, Rebecca; Singh, Karam B.; Manners, John M.; Taylor, Jennifer M.

2015-01-01

Pathogens and hosts are in an ongoing arms race and genes involved in host–pathogen interactions are likely to undergo diversifying selection. Fusarium plant pathogens have evolved diverse infection strategies, but how they interact with their hosts in the biotrophic infection stage remains puzzling. To address this, we analyzed the genomes of three Fusarium plant pathogens for genes that are under diversifying selection. We found a two-speed genome structure both on the chromosome and gene group level. Diversifying selection acts strongly on the dispensable chromosomes in Fusarium oxysporum f. sp. lycopersici and on distinct core chromosome regions in Fusarium graminearum, all of which have associations with virulence. Members of two gene groups evolve rapidly, namely those that encode proteins with an N-terminal [SG]-P-C-[KR]-P sequence motif and proteins that are conserved predominantly in pathogens. Specifically, 29 F. graminearum genes are rapidly evolving, in planta induced and encode secreted proteins, strongly pointing toward effector function. In summary, diversifying selection in Fusarium is strongly reflected as genomic footprints and can be used to predict a small gene set likely to be involved in host–pathogen interactions for experimental verification. PMID:25994930

Teaching physics and understanding infrared thermal imaging

NASA Astrophysics Data System (ADS)

Vollmer, Michael; Möllmann, Klaus-Peter

2017-08-01

Infrared thermal imaging is a very rapidly evolving field. The latest trends are small smartphone IR camera accessories, making infrared imaging a widespread and well-known consumer product. Applications range from medical diagnosis methods via building inspections and industrial predictive maintenance etc. also to visualization in the natural sciences. Infrared cameras do allow qualitative imaging and visualization but also quantitative measurements of the surface temperatures of objects. On the one hand, they are a particularly suitable tool to teach optics and radiation physics and many selected topics in different fields of physics, on the other hand there is an increasing need of engineers and physicists who understand these complex state of the art photonics systems. Therefore students must also learn and understand the physics underlying these systems.

The importance of scientific collecting and natural history museums for comparative neuroanatomy.

PubMed

Iwaniuk, Andrew N

2011-05-01

The comparative study of vertebrate brains is inherently dependent upon access to a sufficient number of species and specimens to perform meaningful comparisons. Although many studies rely on compiling published information, continued specimen collection, in addition to more extensive use of existing brain collections and natural history museums, are crucial for detailed neuroanatomical comparisons across species. This review highlights the importance of collecting species through a variety of means, details a marsupial brain collection, and stresses the potential of natural history museums as a resource for comparative neuroanatomy. By taking advantage of as many of these resources as possible, researchers can rapidly increase species coverage and generate a better understanding of how the brain evolves. © 2011 New York Academy of Sciences.

Coral reef management and conservation in light of rapidly evolving ecological paradigms.

PubMed

Mumby, Peter J; Steneck, Robert S

2008-10-01

The decline of many coral reef ecosystems in recent decades surprised experienced managers and researchers. It shattered old paradigms that these diverse ecosystems are spatially uniform and temporally stable on the scale of millennia. We now see reefs as heterogeneous, fragile, globally stressed ecosystems structured by strong positive or negative feedback processes. We review the causes and consequences of reef decline and ask whether management practices are addressing the problem at appropriate scales. We conclude that both science and management are currently failing to address the comanagement of extractive activities and ecological processes that drive ecosystems (e.g. productivity and herbivory). Most reef conservation efforts are directed toward reserve implementation, but new approaches are needed to sustain ecosystem function in exploited areas.

Blending research and practice: an evolving dissemination strategy in substance abuse.

PubMed

Michel, Mary Ellen; Pintello, Denise A; Subramaniam, Geetha

2013-01-01

Substance abuse is a leading cause of death and disability throughout the world. The mission of the National Institute on Drug Abuse (NIDA) is to lead the United States in bringing the power of science to bear on drug abuse and addiction. This charge has two critical components: (a) strategic support of research across a broad range of disciplines and (b) rapid, effective dissemination of research results that can improve prevention and treatment efforts, with potential to inform policy. The NIDA Clinical Trials Network and the Blending Initiative are critical elements of this strategy, and the social work field is poised to use these resources to expand its role in the dissemination and implementation of NIDA's mission.

Epigenetics and therapeutic targets mediating neuroprotection.

PubMed

Qureshi, Irfan A; Mehler, Mark F

2015-12-02

The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses. This article is part of a Special Issue entitled SI: Neuroprotection. Copyright © 2015 Elsevier B.V. All rights reserved.

Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila.

PubMed

Levin, Tera C; Malik, Harmit S

2017-09-01

Animal Toll-like receptors (TLRs) have evolved through a pattern of duplication and divergence. Whereas mammalian TLRs directly recognize microbial ligands, Drosophila Tolls bind endogenous ligands downstream of both developmental and immune signaling cascades. Here, we find that most Toll genes in Drosophila evolve slowly with little gene turnover (gains/losses), consistent with their important roles in development and indirect roles in microbial recognition. In contrast, we find that the Toll-3/4 genes have experienced an unusually rapid rate of gene gains and losses, resulting in lineage-specific Toll-3/4s and vastly different gene repertoires among Drosophila species, from zero copies (e.g., D. mojavensis) to nineteen copies (e.g., D. willistoni). In D. willistoni, we find strong evidence for positive selection in Toll-3/4 genes, localized specifically to an extracellular region predicted to overlap with the binding site of Spätzle, the only known ligand of insect Tolls. However, because Spätzle genes are not experiencing similar selective pressures, we hypothesize that Toll-3/4s may be rapidly evolving because they bind to a different ligand, akin to TLRs outside of insects. We further find that most Drosophila Toll-3/4 genes are either weakly expressed or expressed exclusively in males, specifically in the germline. Unlike other Toll genes in D. melanogaster, Toll-3, and Toll-4 have apparently escaped from essential developmental roles, as knockdowns have no substantial effects on viability or male fertility. Based on these findings, we propose that the Toll-3/4 genes represent an exceptionally rapidly evolving lineage of Drosophila Toll genes, which play an unusual, as-yet-undiscovered role in the male germline. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila

PubMed Central

Levin, Tera C.; Malik, Harmit S.

2017-01-01

Abstract Animal Toll-like receptors (TLRs) have evolved through a pattern of duplication and divergence. Whereas mammalian TLRs directly recognize microbial ligands, Drosophila Tolls bind endogenous ligands downstream of both developmental and immune signaling cascades. Here, we find that most Toll genes in Drosophila evolve slowly with little gene turnover (gains/losses), consistent with their important roles in development and indirect roles in microbial recognition. In contrast, we find that the Toll-3/4 genes have experienced an unusually rapid rate of gene gains and losses, resulting in lineage-specific Toll-3/4s and vastly different gene repertoires among Drosophila species, from zero copies (e.g., D. mojavensis) to nineteen copies (e.g., D. willistoni). In D. willistoni, we find strong evidence for positive selection in Toll-3/4 genes, localized specifically to an extracellular region predicted to overlap with the binding site of Spätzle, the only known ligand of insect Tolls. However, because Spätzle genes are not experiencing similar selective pressures, we hypothesize that Toll-3/4s may be rapidly evolving because they bind to a different ligand, akin to TLRs outside of insects. We further find that most Drosophila Toll-3/4 genes are either weakly expressed or expressed exclusively in males, specifically in the germline. Unlike other Toll genes in D. melanogaster, Toll-3, and Toll-4 have apparently escaped from essential developmental roles, as knockdowns have no substantial effects on viability or male fertility. Based on these findings, we propose that the Toll-3/4 genes represent an exceptionally rapidly evolving lineage of Drosophila Toll genes, which play an unusual, as-yet-undiscovered role in the male germline. PMID:28541576

A fibre based triature interferometer for measuring rapidly evolving, ablatively driven plasma densities

NASA Astrophysics Data System (ADS)

Macdonald, J.; Bland, S. N.; Threadgold, J.

2015-08-01

We report on the first use of a fibre interferometer incorporating triature analysis for measuring rapidly evolving plasma densities of ne ˜ 1013/cm3 and above, such as those produced by simple coaxial plasma guns. The resultant system is extremely portable, easy to field in experiments, relatively cheap to produce, and—with the exception of a small open area in which the plasma is sampled—safe in operation as all laser light is enclosed.

Nanotechnology in Corneal Neovascularization Therapy—A Review

PubMed Central

Gonzalez, Lilian; Loza, Raymond J.; Han, Kyu-Yeon; Sunoqrot, Suhair; Cunningham, Christy; Purta, Patryk; Drake, James; Jain, Sandeep; Hong, Seungpyo

2013-01-01

Abstract Nanotechnology is an up-and-coming branch of science that studies and designs materials with at least one dimension sized from 1–100 nm. These nanomaterials have unique functions at the cellular, atomic, and molecular levels.1 The term “nanotechnology” was first coined in 1974.2 Since then, it has evolved dramatically and now consists of distinct and independent scientific fields. Nanotechnology is a highly studied topic of interest, as nanoparticles can be applied to various fields ranging from medicine and pharmacology, to chemistry and agriculture, to environmental science and consumer goods.3 The rapidly evolving field of nanomedicine incorporates nanotechnology with medical applications, seeking to give rise to new diagnostic means, treatments, and tools. Over the past two decades, numerous studies that underscore the successful fusion of nanotechnology with novel medical applications have emerged. This has given rise to promising new therapies for a variety of diseases, especially cancer. It is becoming abundantly clear that nanotechnology has found a place in the medical field by providing new and more efficient ways to deliver treatment. Ophthalmology can also stand to benefit significantly from the advances in nanotechnology research. As it relates to the eye, research in the nanomedicine field has been particularly focused on developing various treatments to prevent and/or reduce corneal neovascularization among other ophthalmologic disorders. This review article aims to provide an overview of corneal neovascularization, currently available treatments, and where nanotechnology comes into play. PMID:23425431

Exposure science in an age of rapidly changing climate: challenges and opportunities

PubMed Central

LaKind, Judy S; Overpeck, Jonathan; Breysse, Patrick N; Backer, Lorrie; Richardson, Susan D; Sobus, Jon; Sapkota, Amir; Upperman, Crystal R; Jiang, Chengsheng; Beard, C Ben; Brunkard, J M; Bell, Jesse E; Harris, Ryan; Chretien, Jean-Paul; Peltier, Richard E; Chew, Ginger L; Blount, Benjamin C

2016-01-01

Climate change is anticipated to alter the production, use, release, and fate of environmental chemicals, likely leading to increased uncertainty in exposure and human health risk predictions. Exposure science provides a key connection between changes in climate and associated health outcomes. The theme of the 2015 Annual Meeting of the International Society of Exposure Science—Exposures in an Evolving Environment—brought this issue to the fore. By directing attention to questions that may affect society in profound ways, exposure scientists have an opportunity to conduct “consequential science”—doing science that matters, using our tools for the greater good and to answer key policy questions, and identifying causes leading to implementation of solutions. Understanding the implications of changing exposures on public health may be one of the most consequential areas of study in which exposure scientists could currently be engaged. In this paper, we use a series of case studies to identify exposure data gaps and research paths that will enable us to capture the information necessary for understanding climate change-related human exposures and consequent health impacts. We hope that paper will focus attention on under-developed areas of exposure science that will likely have broad implications for public health. PMID:27485992

A conceptual framework to support exposure science research ...

EPA Pesticide Factsheets

While knowledge of exposure is fundamental to assessing and mitigating risks, exposure information has been costly and difficult to generate. Driven by major scientific advances in analytical methods, biomonitoring, computational tools, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition that allows it to be more agile, predictive, and data- and knowledge-driven. A necessary element of this evolved paradigm is an organizational and predictive framework for exposure science that furthers the application of systems-based approaches. To enable such systems-based approaches, we proposed the Aggregate Exposure Pathway (AEP) concept to organize data and information emerging from an invigorated and expanding field of exposure science. The AEP framework is a layered structure that describes the elements of an exposure pathway, as well as the relationship between those elements. The basic building blocks of an AEP adopt the naming conventions used for Adverse Outcome Pathways (AOPs): Key Events (KEs) to describe the measurable, obligate steps through the AEP; and Key Event Relationships (KERs) describe the linkages between KEs. Importantly, the AEP offers an intuitive approach to organize exposure information from sources to internal site of action, setting the stage for predicting stressor concentrations at an internal target site. These predicted concentrations can help inform the r

The evolution of science literacy: Examining intertextual connections and inquiry behaviors in the classroom

NASA Astrophysics Data System (ADS)

Manocchi-Verrino, Carol J.

A call for a new perspective of science literacy has been marked as the impetus of change in science education, suggesting that a meaning-making approach to literacy and inquiry are central to learning science. This research study explored how science literacy evolved in a classroom where this reconceptualized view of science literacy guided curriculum design and instruction. The teacher/researcher incorporated Interactive Science Notebooks (ISNs) and Interactive Reading Organizers and Comprehension Strategies (IROCS) into instructional materials. In a class consisting of 20 mainstream and special education students, this 7-week study collected data using Likert scales, stimulated recall interviews, a teacher/researcher journal, and students¡¦ position papers. A systematic design framework was used for the three-phase analysis. Hyperresearch RTM software facilitated the identification of open codes, an axial code, and frequency graphs. In order to develop insight into the relationship between questions, methods, and curriculum design recent recommendations for quality research in science education were considered in the methodology. The hypothesis formulated from the data suggests that science literacy evolves on a continuum, and the degree to which science literacy evolves on the continuum seems to be contingent upon their uses of intertextual connections and inquiry behaviors. Several notable insights emerged from the data which were used to guide curriculum, instruction, and assessment that promotes the development of science literacy in the middle school classroom. The study suggests a possible correlation between the use of intertextual connections and inquiry behaviors, and the use of a continuum in measuring the emergence of science literacy.

Big Data: An Opportunity for Collaboration with Computer Scientists on Data-Driven Science

NASA Astrophysics Data System (ADS)

Baru, C.

2014-12-01

Big data technologies are evolving rapidly, driven by the need to manage ever increasing amounts of historical data; process relentless streams of human and machine-generated data; and integrate data of heterogeneous structure from extremely heterogeneous sources of information. Big data is inherently an application-driven problem. Developing the right technologies requires an understanding of the applications domain. Though, an intriguing aspect of this phenomenon is that the availability of the data itself enables new applications not previously conceived of! In this talk, we will discuss how the big data phenomenon creates an imperative for collaboration among domain scientists (in this case, geoscientists) and computer scientists. Domain scientists provide the application requirements as well as insights about the data involved, while computer scientists help assess whether problems can be solved with currently available technologies or require adaptaion of existing technologies and/or development of new technologies. The synergy can create vibrant collaborations potentially leading to new science insights as well as development of new data technologies and systems. The area of interface between geosciences and computer science, also referred to as geoinformatics is, we believe, a fertile area for interdisciplinary research.

RAPIDLY EVOLVING AND LUMINOUS TRANSIENTS DRIVEN BY NEWLY BORN NEUTRON STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Yun-Wei; Li, Shao-Ze; Dai, Zi-Gao, E-mail: yuyw@mail.ccnu.edu.cn

2015-06-10

We provide a general analysis on the properties of the emitting material of some rapidly evolving and luminous transients discovered recently with the Pan-STARRS1 Medium Deep Survey. It was found that these transients are probably produced by a low-mass non-relativistic outflow that is continuously powered by a newly born, rapidly spinning, and highly magnetized neutron star (NS). Such a system could originate from an accretion-induced collapse of a white dwarf or a merger of an NS–NS binary. Therefore, observations of these transients would be helpful for constraining white dwarf and NS physics and/or for searching and identifying gravitational wave signals frommore » the mergers.« less

FOCAL PLANE WAVEFRONT SENSING USING RESIDUAL ADAPTIVE OPTICS SPECKLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Codona, Johanan L.; Kenworthy, Matthew, E-mail: jlcodona@gmail.com

2013-04-20

Optical imperfections, misalignments, aberrations, and even dust can significantly limit sensitivity in high-contrast imaging systems such as coronagraphs. An upstream deformable mirror (DM) in the pupil can be used to correct or compensate for these flaws, either to enhance the Strehl ratio or suppress the residual coronagraphic halo. Measurement of the phase and amplitude of the starlight halo at the science camera is essential for determining the DM shape that compensates for any non-common-path (NCP) wavefront errors. Using DM displacement ripples to create a series of probe and anti-halo speckles in the focal plane has been proposed for space-based coronagraphsmore » and successfully demonstrated in the lab. We present the theory and first on-sky demonstration of a technique to measure the complex halo using the rapidly changing residual atmospheric speckles at the 6.5 m MMT telescope using the Clio mid-IR camera. The AO system's wavefront sensor measurements are used to estimate the residual wavefront, allowing us to approximately compute the rapidly evolving phase and amplitude of speckle halo. When combined with relatively short, synchronized science camera images, the complex speckle estimates can be used to interferometrically analyze the images, leading to an estimate of the static diffraction halo with NCP effects included. In an operational system, this information could be collected continuously and used to iteratively correct quasi-static NCP errors or suppress imperfect coronagraphic halos.« less

Students from Pueblo Triumph in Colorado Science Bowl

Science.gov Websites

questions about physics, math, biology, astronomy, chemistry, computers and the earth sciences, students science and math. The competition has evolved into one of the Energy Department's premier educational

Students from Aurora Triumph in Denver Regional Science Bowl

Science.gov Websites

questions about physics, math, biology, astronomy, chemistry, computers and the earth sciences, students science and math. The competition has evolved into one of the Energy Department's premier educational

BOOK REVIEW: OPENING SCIENCE, THE EVOLVING GUIDE ...

EPA Pesticide Factsheets

The way we get our funding, collaborate, do our research, and get the word out has evolved over hundreds of years but we can imagine a more open science world, largely facilitated by the internet. The movement towards this more open way of doing and presenting science is coming, and it is not taking hundreds of years. If you are interested in these trends, and would like to find out more about where this is all headed and what it means to you, consider downloding Opening Science, edited by Sönke Bartling and Sascha Friesike, subtitled The Evolving Guide on How the Internet is Changing Research, Collaboration, and Scholarly Publishing. In 26 chapters by various authors from a range of disciplines the book explores the developing world of open science, starting from the first scientific revolution and bringing us to the next scientific revolution, sometimes referred to as “Science 2.0”. Some of the articles deal with the impact of the changing landscape of how science is done, looking at the impact of open science on Academia, or journal publishing, or medical research. Many of the articles look at the uses, pitfalls, and impact of specific tools, like microblogging (think Twitter), social networking, and reference management. There is lots of discussion and definition of terms you might use or misuse like “altmetrics” and “impact factor”. Science will probably never be completely open, and Twitter will probably never replace the journal article,

Science Fiction: Coping with Change.

ERIC Educational Resources Information Center

Tymn, Marshall B.

1979-01-01

Notes that science fiction has evolved into a literature of serious social commentary while still preserving its origins of romantic escapism and intriguing gadgetry. Argues that science fiction now looks more closely at life on Earth. (FL)

Environmental Noise, Genetic Diversity and the Evolution of Evolvability and Robustness in Model Gene Networks

PubMed Central

Steiner, Christopher F.

2012-01-01

The ability of organisms to adapt and persist in the face of environmental change is accepted as a fundamental feature of natural systems. More contentious is whether the capacity of organisms to adapt (or “evolvability”) can itself evolve and the mechanisms underlying such responses. Using model gene networks, I provide evidence that evolvability emerges more readily when populations experience positively autocorrelated environmental noise (red noise) compared to populations in stable or randomly varying (white noise) environments. Evolvability was correlated with increasing genetic robustness to effects on network viability and decreasing robustness to effects on phenotypic expression; populations whose networks displayed greater viability robustness and lower phenotypic robustness produced more additive genetic variation and adapted more rapidly in novel environments. Patterns of selection for robustness varied antagonistically with epistatic effects of mutations on viability and phenotypic expression, suggesting that trade-offs between these properties may constrain their evolutionary responses. Evolution of evolvability and robustness was stronger in sexual populations compared to asexual populations indicating that enhanced genetic variation under fluctuating selection combined with recombination load is a primary driver of the emergence of evolvability. These results provide insight into the mechanisms potentially underlying rapid adaptation as well as the environmental conditions that drive the evolution of genetic interactions. PMID:23284934

Climate Modeling Computing Needs Assessment

NASA Astrophysics Data System (ADS)

Petraska, K. E.; McCabe, J. D.

2011-12-01

This paper discusses early findings of an assessment of computing needs for NASA science, engineering and flight communities. The purpose of this assessment is to document a comprehensive set of computing needs that will allow us to better evaluate whether our computing assets are adequately structured to meet evolving demand. The early results are interesting, already pointing out improvements we can make today to get more out of the computing capacity we have, as well as potential game changing innovations for the future in how we apply information technology to science computing. Our objective is to learn how to leverage our resources in the best way possible to do more science for less money. Our approach in this assessment is threefold: Development of use case studies for science workflows; Creating a taxonomy and structure for describing science computing requirements; and characterizing agency computing, analysis, and visualization resources. As projects evolve, science data sets increase in a number of ways: in size, scope, timelines, complexity, and fidelity. Generating, processing, moving, and analyzing these data sets places distinct and discernable requirements on underlying computing, analysis, storage, and visualization systems. The initial focus group for this assessment is the Earth Science modeling community within NASA's Science Mission Directorate (SMD). As the assessment evolves, this focus will expand to other science communities across the agency. We will discuss our use cases, our framework for requirements and our characterizations, as well as our interview process, what we learned and how we plan to improve our materials after using them in the first round of interviews in the Earth Science Modeling community. We will describe our plans for how to expand this assessment, first into the Earth Science data analysis and remote sensing communities, and then throughout the full community of science, engineering and flight at NASA.

Implementing Innovations in Global Women's, Children's, and Adolescents' Health: Realizing the Potential for Implementation Science.

PubMed

Peterson, Herbert B; Haidar, Joumana; Fixsen, Dean; Ramaswamy, Rohit; Weiner, Bryan J; Leatherman, Sheila

2018-03-01

The launch of the United Nations Sustainable Development Goals and the new Secretary General's Global Strategy for Women's, Children's, and Adolescents' Health are a window of opportunity for improving the health and well-being of women, children, and adolescents in the United States and around the world. Realizing the full potential of this historic moment will require that we improve our ability to successfully implement life-saving and life-enhancing innovations, particularly in low-resource settings. Implementation science, a new and rapidly evolving field that addresses the "how-to" component of providing sustainable quality services at scale, can make an important contribution on this front. A synthesis of the implementation science evidence indicates that three interrelated factors are required for successful, sustainable outcomes at scale: 1) effective innovations, 2) effective implementation, and 3) enabling contexts. Implementation science addresses the interaction among these factors to help make innovations more usable, to build ongoing capacity to assure the effective implementation of these innovations, and to ensure enabling contexts to sustain their full and effective use in practice. Improving access to quality services will require transforming health care systems and, therefore, much of the focus of implementation science in global health is on improving the ability of health systems to serve as enabling contexts. The field of implementation science is inherently interdisciplinary and academe will need to respond by facilitating collaboration among scientists from relevant disciplines, including evaluation, improvement, and systems sciences. Platforms and programs to facilitate collaborations among researchers, practitioners, policymakers, and funders are likewise essential.

Evolving the future: Toward a science of intentional change

PubMed Central

Wilson, David Sloan; Hayes, Steven C.; Biglan, Anthony; Embry, Dennis D.

2015-01-01

Humans possess great capacity for behavioral and cultural change, but our ability to manage change is still limited. This article has two major objectives: first, to sketch a basic science of intentional change centered on evolution; second, to provide examples of intentional behavioral and cultural change from the applied behavioral sciences, which are largely unknown to the basic sciences community. All species have evolved mechanisms of phenotypic plasticity that enable them to respond adaptively to their environments. Some mechanisms of phenotypic plasticity count as evolutionary processes in their own right. The human capacity for symbolic thought provides an inheritance system having the same kind of combinatorial diversity as does genetic recombination and antibody formation. Taking these propositions seriously allows an integration of major traditions within the basic behavioral sciences, such as behaviorism, social constructivism, social psychology, cognitive psychology, and evolutionary psychology, which are often isolated and even conceptualized as opposed to one another. The applied behavioral sciences include well-validated examples of successfully managing behavioral and cultural change at scales ranging from individuals to small groups to large populations. However, these examples are largely unknown beyond their disciplinary boundaries, for lack of a unifying theoretical framework. Viewed from an evolutionary perspective, they are examples of managing evolved mechanisms of phenotypic plasticity, including open-ended processes of variation and selection. Once the many branches of the basic and applied behavioral sciences become conceptually unified, we are closer to a science of intentional change than one might think. PMID:24826907

Beyond the Paleolithic prescription: incorporating diversity and flexibility in the study of human diet evolution.

PubMed

Turner, Bethany L; Thompson, Amanda L

2013-08-01

Evolutionary paradigms of human health and nutrition center on the evolutionary discordance or "mismatch" model in which human bodies, reflecting adaptations established in the Paleolithic era, are ill-suited to modern industrialized diets, resulting in rapidly increasing rates of chronic metabolic disease. Though this model remains useful, its utility in explaining the evolution of human dietary tendencies is limited. The assumption that human diets are mismatched to the evolved biology of humans implies that the human diet is instinctual or genetically determined and rooted in the Paleolithic era. This review looks at current research indicating that human eating habits are learned primarily through behavioral, social, and physiological mechanisms that start in utero and extend throughout the life course. Adaptations that appear to be strongly genetic likely reflect Neolithic, rather than Paleolithic, adaptations and are significantly influenced by human niche-constructing behavior. Several examples are used to conclude that incorporating a broader understanding of both the evolved mechanisms by which humans learn and imprint eating habits and the reciprocal effects of those habits on physiology would provide useful tools for structuring more lasting nutrition interventions. © 2013 International Life Sciences Institute.

[Invisible and almost invisible orthodontic appliances].

PubMed

Baron, Pascal

2014-03-01

Patient demand for invisible esthetic orthodontic appliances is steadily increasing. Two types of orthodontic appliances have a high rate of patient acceptance. The lingual technique has continually evolved by offering both prefabricated brackets or custom-made brackets. The various techniques have been improved over time, and the results are better than ever. Thermoplastic aligners are an alternative to lingual devices and their use is rapidly growing. Their specific properties make it easier to assess their indications and limitations. A review of the literature, the development of these systems and a presentation of some clinical examples of treated cases will help us to provide some of the basics for understanding each of these two types of appliances and to demonstrate the advantages and disadvantages of each system. © EDP Sciences, SFODF, 2014.

Rapidly rotating single late-type giants: New FK Comae stars?

NASA Technical Reports Server (NTRS)

Fekel, Francis C.

1986-01-01

A group of rapidly rotating single late-type giants was found from surveys of chromospherically active stars. These stars have V sin I's ranging from 6 to 46 km/sec, modest ultraviolet emission line fluxes, and strong H alpha absorption lines. Although certainly chromospherically active, their characteristics are much less extreme than those of FK Com and one or two other similar systems. One possible explanation for the newly identified systems is that they have evolved from stars similar to FK Com. The chromospheric activity and rotation of single giant stars like FK Com would be expected to decrease with time as they do in single dwarfs. Alternatively, this newly identified group may have evolved from single rapidly rotating A, or early F stars.

Transforming Information Literacy in the Sciences through the Lens of e-Science

ERIC Educational Resources Information Center

Berman, Elizabeth

2013-01-01

In 2011, the ACRL Science & Technology Section (STS) completed its five-year review of the "Information Literacy Standards for Science and Engineering/Technology." Predicated by the evolving nature of scholarship and research in the sciences, the reviewing task force strongly recommended that the standards be revised. This paper…

As Science Evolves, How Can Science Policy? NBER Working Paper No. 16002

ERIC Educational Resources Information Center

Jones, Benjamin

2010-01-01

Getting science policy right is a core objective of government that bears on scientific advance, economic growth, health, and longevity. Yet the process of science is changing. As science advances and knowledge accumulates, ensuing generations of innovators spend longer in training and become more narrowly expert, shifting key innovations (i)…

Pyroshock: Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmerman, R.M.

1993-01-01

This paper represents a review copy for text that is to be included in the Shock and Vibration Recommended Practice Document. This section on pyroshock is written an a general introduction to and description of the topic loading to presentation of an extensive bibliography on the subject. Pyroshock is an evolving science that needs continued focus on both achieving improvements in testing and measurement techniques and advancing instrumentation capabilities. When desired in the near future, recommended practices can be presented. Pyroshock phenomena are associated with separation systems of missiles. spacecraft, and in some cases airplanes. During launch, a rocket drivenmore » vehicle may be exposed to 19 to 30 g's of acceleration with predominant frequencies less than 200 Hz. After launch or takeoffs sections or parts of vehicles may be separated rapidly using explosive driven release mechanisms. Separations can involve stage disconnections for spacecraft sections or payload ejections from missiles and airplanes. At separation, localized pyrotechnic induced accelerations may range from 1000 to over 100,000 g's at frequencies much higher than 1000 Hz. These pyroshocks are characterized by high intensity, high frequency transients that decay rapidly. Pyroshock impulses have insignificant velocity changes.« less

Plates and Mantle Convection: A Far-From Equilibrium Self-Organized System

NASA Astrophysics Data System (ADS)

King, S. D.; Lowman, J. P.; Gable, C. W.

2001-12-01

A common observation of plate tectonics is that plate velocities change over short time scales. Some have speculated that these reorganization events are triggered by evolving plate boundaries. This work presents an alternative mechanism, due to the interaction of mobil plates and internally heated convection. We present numerical models of 3D Cartesian convection in an internally-heated fluid with mobile plates that exhibit rapid changes in plate motion. A persistent feature of these calculations is that plate motion is relatively uniform punctuated by rapid reorganization events where plate speed and direction change over a short time period. The rapid changes in plate motion result solely from the interaction of internally-heated convection and the mobile plates. Without plates, the convective planform of an internally-heated fluid evolves into a pattern with a larger number of small cells. When plates are included, the fluid is dominated by plate-scale structures; however, isolated regions develop where heat builds up. These isolated regions are near the location of mature slabs where the plates are older and thicker. As the system evolves, the temperature (and buoyancy) in these isolated regions increases, they become unstable and, as they rise, the net force on the plate is no longer dominated by `slab pull' from the mature slab. The plate reorganization allows the system to transfer heat from the short-wavelength, internal-heating scale, to the longer-wavelength, plate-cooling scale. As we will demonstrate, the interaction between plate motions and the mantle is sufficiently dynamic that evolving plate boundaries are not necessary to achieve rapid changes in plate motion.

Osmoregulatory physiology and rapid evolution of salinity tolerance in threespine stickleback recently introduced to fresh water

USGS Publications Warehouse

Divino, Jeffrey N; Monette, Michelle Y.; McCormick, Stephen; Yancey, Paul H.; Flannery, Kyle G.; Bell, Michael A.; Rollins, Jennifer L.; von Hippel, Frank A.; Schultz, Eric T.

2016-01-01

Conclusion: Enhanced freshwater tolerance has evolved rapidly in recently landlocked stickleback compared with their anadromous ancestors (0.569 haldanes), but the former have retained ancestral seawater-osmoregulatory function.

RAPIDLY ROTATING, X-RAY BRIGHT STARS IN THE KEPLER FIELD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howell, Steve B.; Mason, Elena; Boyd, Patricia

We present Kepler light curves and optical spectroscopy of twenty X-ray bright stars located in the Kepler field of view. The stars, spectral type F-K, show evidence for rapid rotation including chromospheric activity 100 times or more above the Sun at maximum and flaring behavior in their light curves. Eighteen of our objects appear to be (sub)giants and may belong to the class of FK Com variables, which are evolved rapidly spinning single stars with no excretion disk and high levels of chromospheric activity. Such stars are rare and are likely the result of W UMa binary mergers, a processmore » believed to produce the FK Com class of variable and their descendants. The FK Com stage, including the presence of an excretion disk, is short lived but leads to longer-lived stages consisting of single, rapidly rotating evolved (sub)giants with high levels of stellar activity.« less

Rapidly Rotating, X-Ray Bright Stars in the Kepler Field

NASA Technical Reports Server (NTRS)

Howell, Steve B.; Mason, Elena; Boyd, Patricia; Smith, Krista Lynne; Gelino, Dawn M.

2016-01-01

We present Kepler light curves and optical spectroscopy of twenty X-ray bright stars located in the Kepler field of view. The stars, spectral type F-K, show evidence for rapid rotation including chromospheric activity 100 times or more above the Sun at maximum and flaring behavior in their light curves. Eighteen of our objects appear to be (sub)giants and may belong to the class of FK Com variables, which are evolved rapidly spinning single stars with no excretion disk and high levels of chromospheric activity. Such stars are rare and are likely the result of W UMa binary mergers, a process believed to produce the FK Com class of variable and their descendants. The FK Com stage, including the presence of an excretion disk, is short lived but leads to longer-lived stages consisting of single, rapidly rotating evolved (sub)giants with high levels of stellar activity.

Students from Grand Junction High School Triumph in Colorado Science Bowl

Science.gov Websites

-fire questions about physics, math, biology, astronomy, chemistry, computers and the earth sciences years ago to help stimulate interest in science and math. The competition has evolved into one of the

High School Students Gear Up for Battle of the Brains

Science.gov Websites

focuses on physics, math, biology, astronomy, chemistry, computers and the earth sciences. Each team is Science Bowl a decade ago to help stimulate interest in science and math. The competition has evolved into

Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species

EPA Science Inventory

Atlantic killifish (Fundulus heteroclitus) residing in some urban and industrialized estuaries of the US eastern seaboard demonstrate recently evolved and extreme tolerance to toxic aryl hydrocarbon pollutants, characterized as dioxin-like compounds (DLCs). Here we provide an unu...

Using integrated research and interdisciplinary science: Potential benefits and challenges to managers of parks and protected areas

USGS Publications Warehouse

van Riper, Charles; Powell, Robert B.; Machlis, Gary; van Wagtendonk, Jan W.; van Riper, Carena J.; von Ruschkowski, Eick; Schwarzbach, Steven E.; Galipeau, Russell E.

2012-01-01

Our purpose in this paper is to build a case for utilizing interdisciplinary science to enhance the management of parks and protected areas. We suggest that interdisciplinary science is necessary for dealing with the complex issues of contemporary resource management, and that using the best available integrated scientific information be embraced and supported at all levels of agencies that manage parks and protected areas. It will take the commitment of park managers, scientists, and agency leaders to achieve the goal of implementing the results of interdisciplinary science into park management. Although such calls go back at least several decades, today interdisciplinary science is sporadically being promoted as necessary for supporting effective protected area management(e.g., Machlis et al. 1981; Kelleher and Kenchington 1991). Despite this history, rarely has "interdisciplinary science" been defined, its importance explained, or guidance provided on how to translate and then implement the associated research results into management actions (Tress et al. 2006; Margles et al. 2010). With the extremely complex issues that now confront protected areas (e.g., climate change influences, extinctions and loss of biodiversity, human and wildlife demographic changes, and unprecedented human population growth) information from more than one scientific discipline will need to be brought to bear in order to achieve sustained management solutions that resonate with stakeholders (Ostrom 2009). Although interdisciplinary science is not the solution to all problems, we argue that interdisciplinary research is an evolving and widely supported best practice. In the case of park and protected area management, interdisciplinary science is being driven by the increasing recognition of the complexity and interconnectedness of human and natural systems, and the notion that addressing many problems can be more rapidly advanced through interdisciplinary study and analysis.

Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases

NASA Astrophysics Data System (ADS)

Park, Solip; Yang, Jae-Seong; Kim, Jinho; Shin, Young-Eun; Hwang, Jihye; Park, Juyong; Jang, Sung Key; Kim, Sanguk

2012-10-01

The extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slowly or rapidly evolving classes, where the diseases in the slowly evolving class are enriched with morphological phenotypes and those in the rapidly evolving class are enriched with physiological phenotypes. Our findings establish a clear evolutionary connection between disease classes and disease phenotypes for the first time. Furthermore, the high comorbidity found between diseases connected by similar evolutionary constraints enables us to improve the predictability of the relative risk of human diseases. We find the evolutionary constraints on disease genes are a new layer of molecular connection in the network-based exploration of human diseases.

Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases.

PubMed

Park, Solip; Yang, Jae-Seong; Kim, Jinho; Shin, Young-Eun; Hwang, Jihye; Park, Juyong; Jang, Sung Key; Kim, Sanguk

2012-01-01

The extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slowly or rapidly evolving classes, where the diseases in the slowly evolving class are enriched with morphological phenotypes and those in the rapidly evolving class are enriched with physiological phenotypes. Our findings establish a clear evolutionary connection between disease classes and disease phenotypes for the first time. Furthermore, the high comorbidity found between diseases connected by similar evolutionary constraints enables us to improve the predictability of the relative risk of human diseases. We find the evolutionary constraints on disease genes are a new layer of molecular connection in the network-based exploration of human diseases.

Technology Development, Implementation and Assessment: K-16 Pre-Service, In-Service and Distance Learning Initiatives

NASA Technical Reports Server (NTRS)

Williams, William B., Jr.

1999-01-01

The technologies associated with distance learning are evolving rapidly, giving to educators a potential tool for enhancing the educational experiences of large numbers of students simultaneously. This enhancement, in order to be effective, must take into account the various agendas of teachers, administrators, state systems, and of course students. It must also make use of the latest research on effective pedagogy. This combination, effective pedagogy and robust information technology, is a powerful vehicle for communicating, to a large audience of school children the excitement of mathematics and science--an excitement that for the most part is now well-hidden. This project,"Technology Development, Implementation and Assessment," proposed to bring to bear on the education of learners in grades 3 - 8 in science and mathematics both advances in information technology and in effective pedagogy. Specifically, the project developed components NASA CONNECT video series--problem-based learning modules that focus on the scientific method and that incorporate problem-based learning scenarios tied to national mathematics and science standards. These videos serve two purposes; they engage students in the excitement of hands-on learning and they model for the teachers of these students the problem-based learning practices that are proving to be excellent ways to teach science and mathematics to school students. Another component of NASA CONNECT is the accompanying web-site.

Putting the International Space Station to work.

PubMed

Clancy, Paul

2003-08-01

The International Space Station (ISS) is the largest international cooperative science and technology project ever undertaken. Involving the United States, Russia, Japan, Canada and 10 ESA Member States, it is now rapidly becoming a reality in orbit, offering unprecedented access for research and applications under space conditions. Europe has invested heavily in this endeavour and plans to exploit that investment by a vigorous utilisation of the ISS for life and physical sciences research and applications, space science, Earth observation, space technology development, the promotion of commercial access to space, and the use of space for educational purposes. In recent years, ESA has engaged in an intensive promotional effort to encourage potential user communities to exploit the novel opportunities that the ISS offers. It has also made significant financial commitments to develop both multi-user facilities for life and physical sciences studies in the Columbus Laboratory, and observational and technology exposure instruments using the external Columbus mounting locations, as well as giving financial support to promote commercial and educational activities. ESA has now elaborated a European Strategy for the efficient utilisation of the ISS by European scientists and other users, which is being coordinated with the Agency's Member States contributing to the ISS Programme, and with the European Science Foundation (ESF). In cooperation with the European Commission, ESA is also fostering synergy with the European Commission's Framework Programmes in terms of shared R&D objectives. This article describes the plan that has been evolved to integrate all of these various elements.

Mapping Climate Science Information Needs and Networks in the Northwest, USA through Evaluating the Northwest Climate Science Center Climate Science Digest

NASA Astrophysics Data System (ADS)

Gergel, D. R.; Watts, L. H.; Salathe, E. P.; Mankowski, J. D.

2017-12-01

Climate science, already a highly interdisciplinary field, is rapidly evolving, and natural resource managers are increasingly involved in policymaking and adaptation decisions to address climate change that need to be informed by state-of-the-art climate science. Consequently, there is a strong demand for unique organizations that engender collaboration and cooperation between government, non-profit, academic and for-profit sectors that are addressing issues relating to natural resources management and climate adaptation and resilience. These organizations are often referred to as boundary organizations. The Northwest Climate Science Center (NW CSC) and the North Pacific Landscape Conservation Cooperative (NP LCC) are two such boundary organizations operating in different contexts. Together, the NW CSC and the NP LCC fulfill the need for sites of co-production between researchers and managers working on climate-related issues, and a key component of this work is a monthly climate science newsletter that includes recent climate science journal articles, reports, and climate-related events. Our study evaluates the effectiveness of the climate science digest (CSD) through a three-pronged approach: a) in-depth interviews with natural resource managers who use the CSD, b) poll questions distributed to CSD subscribers, and c) quantitative analysis of CSD effectiveness using analytics from MailChimp distribution. We aim to a) map the reach of the CSD across the Northwest and at a national level; b) understand the efficacy of the CSD at communicating climate science to diverse audiences; c) evaluate the usefulness of CSD content for diverse constituencies of subscribers; d) glean transferrable knowledge for future evaluations of boundary management tools; and e) establish a protocol for designing climate science newsletters for other agencies disseminating climate science information. We will present results from all three steps of our evaluation process and describe their implications for future evaluations of climate science communications products and other boundary management tools in the field of natural resources management.

The poverty of embodied cognition.

PubMed

Goldinger, Stephen D; Papesh, Megan H; Barnhart, Anthony S; Hansen, Whitney A; Hout, Michael C

2016-08-01

In recent years, there has been rapidly growing interest in embodied cognition, a multifaceted theoretical proposition that (1) cognitive processes are influenced by the body, (2) cognition exists in the service of action, (3) cognition is situated in the environment, and (4) cognition may occur without internal representations. Many proponents view embodied cognition as the next great paradigm shift for cognitive science. In this article, we critically examine the core ideas from embodied cognition, taking a "thought exercise" approach. We first note that the basic principles from embodiment theory are either unacceptably vague (e.g., the premise that perception is influenced by the body) or they offer nothing new (e.g., cognition evolved to optimize survival, emotions affect cognition, perception-action couplings are important). We next suggest that, for the vast majority of classic findings in cognitive science, embodied cognition offers no scientifically valuable insight. In most cases, the theory has no logical connections to the phenomena, other than some trivially true ideas. Beyond classic laboratory findings, embodiment theory is also unable to adequately address the basic experiences of cognitive life.

The Poverty of Embodied Cognition

PubMed Central

Goldinger, Stephen D.; Papesh, Megan H.; Barnhart, Anthony S.; Hansen, Whitney A.; Hout, Michael C.

2016-01-01

In recent years, there has been rapidly growing interest in Embodied Cognition, a multifaceted theoretical proposition that (1) cognitive processes are influenced by the body, (2) cognition exists in the service of action, (3) cognition is situated in the environment, and (4) cognition may occur without internal representations. Many proponents view embodied cognition as the next great paradigm shift for cognitive science. In this article, we critically examine the core ideas from embodied cognition, taking a “thought exercise” approach. We first note that the basic principles from embodiment theory are either unacceptably vague (e.g., the premise that perception is influenced by the body) or they offer nothing new (e.g., cognition evolved to optimize survival, emotions affect cognition, perception-action couplings are important). We next suggest that, for the vast majority of classic findings in cognitive science, embodied cognition offers no scientifically valuable insight. In most cases, the theory has no logical connections to the phenomena, other than some trivially true ideas. Beyond classic laboratory findings, embodiment theory is also unable to adequately address the basic experiences of cognitive life. PMID:27282990

Evolving water science in the Anthropocene

NASA Astrophysics Data System (ADS)

Savenije, H. H. G.; Hoekstra, A. Y.; van der Zaag, P.

2013-06-01

This paper reviews the changing relation between man and water since the industrial revolution, the period that has been called the Anthropocene because of the unprecedented scale at which humans have altered the planet. We show how the rapidly changing reality urges us to continuously improve our understanding of the complex interactions between man and the water system. The paper starts with demonstrating that hydrology and the science of water resources management have played key roles in human and economic development throughout history; yet these roles have often been marginalised or obscured. Knowledge on hydrology and water resources engineering and management helped to transform the landscape, and thus also the very hydrology within catchments itself. It is only fairly recent that water experts have become self-conscious of such mechanisms, exemplified by several concepts that try to internalise them (integrated water resources management, eco-hydrology, socio-hydrology). We have reached a stage where a more systemic understanding of scale interdependencies can inform the sustainable governance of water systems, using new concepts like precipitationsheds, virtual water transfers, water footprint and water value flow.

Emerging Frontiers of Neuroengineering: A Network Science of Brain Connectivity

PubMed Central

Bassett, Danielle S.; Khambhati, Ankit N.; Grafton, Scott T.

2018-01-01

Neuroengineering is faced with unique challenges in repairing or replacing complex neural systems that are composed of many interacting parts. These interactions form intricate patterns over large spatiotemporal scales and produce emergent behaviors that are difficult to predict from individual elements. Network science provides a particularly appropriate framework in which to study and intervene in such systems by treating neural elements (cells, volumes) as nodes in a graph and neural interactions (synapses, white matter tracts) as edges in that graph. Here, we review the emerging discipline of network neuroscience, which uses and develops tools from graph theory to better understand and manipulate neural systems from micro- to macroscales. We present examples of how human brain imaging data are being modeled with network analysis and underscore potential pitfalls. We then highlight current computational and theoretical frontiers and emphasize their utility in informing diagnosis and monitoring, brain–machine interfaces, and brain stimulation. A flexible and rapidly evolving enterprise, network neuroscience provides a set of powerful approaches and fundamental insights that are critical for the neuroengineer’s tool kit. PMID:28375650

The dynamics of big data and human rights: the case of scientific research.

PubMed

Vayena, Effy; Tasioulas, John

2016-12-28

In this paper, we address the complex relationship between big data and human rights. Because this is a vast terrain, we restrict our focus in two main ways. First, we concentrate on big data applications in scientific research, mostly health-related research. And, second, we concentrate on two human rights: the familiar right to privacy and the less well-known right to science. Our contention is that human rights interact in potentially complex ways with big data, not only constraining it, but also enabling it in various ways; and that such rights are dynamic in character, rather than fixed once and for all, changing in their implications over time in line with changes in the context we inhabit, and also as they interact among themselves in jointly responding to the opportunities and risks thrown up by a changing world. Understanding this dynamic interaction of human rights is crucial for formulating an ethic tailored to the realities-the new capabilities and risks-of the rapidly evolving digital environment.This article is part of the themed issue 'The ethical impact of data science'. © 2016 The Author(s).

A review of competencies needed for health librarians--a comparison of Irish and international practice.

PubMed

Lawton, Aoife; Burns, Jane

2015-06-01

The purpose of this review was to uncover areas of competence which may lead to a baseline of skills for health librarians. A baseline could inform personal development plans for health librarians, criteria for job descriptions and curriculum for library and information science (LIS) courses. This research outlines existing competencies for librarians working in health care as defined by library associations, recent job descriptions and a mapping review of the library and information science literature. This is performed in the context of librarians working in the Irish health system with examples of practice drawn from the Irish experience. Ten areas of competence were found to be common to three of five library associations, which were also common to recent job descriptions. The literature reveals an ever changing working environment for librarians working in health with opportunities for new and evolving roles. The challenge for librarians moving into these roles will be to stay relevant and to keep skills updated in a rapidly moving health and information environment. © 2014 Health Libraries Group.

Amateur astronomers in support of observing campaigns

NASA Astrophysics Data System (ADS)

Yanamandra-Fisher, P.

2014-07-01

The Pro-Am Collaborative Astronomy (PACA) project evolved from the observational campaign of C/2012 S1 or C/ISON. The success of the paradigm shift in scientific research is now implemented in other comet observing campaigns. While PACA identifies a consistent collaborative approach to pro-am collaborations, given the volume of data generated for each campaign, new ways of rapid data analysis, mining access, and storage are needed. Several interesting results emerged from the synergistic inclusion of both social media and amateur astronomers: - the establishment of a network of astronomers and related professionals that can be galvanized into action on short notice to support observing campaigns; - assist in various science investigations pertinent to the campaign; - provide an alert-sounding mechanism should the need arise; - immediate outreach and dissemination of results via our media/blogger members; - provide a forum for discussions between the imagers and modelers to help strategize the observing campaign for maximum benefit. In 2014, two new comet observing campaigns involving pro-am collaborations have been identified: (1) C/2013 A1 (C/Siding Spring) and (2) 67P/Churyumov-Gerasimenko (CG). The evolving need for individual customized observing campaigns has been incorporated into the evolution of PACA (Pro-Am Collaborative Astronomy) portal that currently is focused on comets: from supporting observing campaigns for current comets, legacy data, historical comets; interconnected with social media and a set of shareable documents addressing observational strategies; consistent standards for data; data access, use, and storage, to align with the needs of professional observers. The integration of science, observations by professional and amateur astronomers, and various social media provides a dynamic and evolving collaborative partnership between professional and amateur astronomers. The recent observation of comet 67P, at a magnitude of 21.2, from Siding Spring, Australia, via robotic telescope network, also detected several asteroids in a crowded star field (SSI, Press Release, May 2014). These may be useful in support of the ESA/Gaia mission, which will characterize asteroids and comets to a magnitude of 20. While its network of amateur astronomers has already been established (Thuillot, 2005, ESASP, 576), such observations by robotic telescope networks can provide both astrometry and subsequent science analysis of the data acquired. An additional benefit of amateur network will be to unequivocally recognize asteroids and comets via complementary imaging that is not possible for the mission itself.

An evolving Mars telecommunications network to enable exploration and increase science data return

NASA Technical Reports Server (NTRS)

Edwards, Chad; Komarek, Tomas A.; Noreen, Gary K.; Wilson, Gregory R.

2003-01-01

The coming decade of Mars exploration involves a variety of unique telecommunications challenges. Increasing spatial and spectral resolution of in situ science instruments drive the need for increased bandwidth. At the same time, many innovative and low-cost in situ mission concepts are enabled by energy-efficient relay communications. In response to these needs, the Mars Exploration Program has established a plan for an evolving orbital infrastructure that can provide enhancing and enabling telecommunications services to future Mars missions. We will present the evolving capabilities of this network over the coming decade in terms of specific quantitative metrics such as data volume per sol and required lander energy per Gb of returned data for representative classes of Mars exploration spacecraft.

Evolving a Method to Capture Science Stakeholder Inputs to Optimize Instrument, Payload, and Program Design

NASA Astrophysics Data System (ADS)

Clark, P. E.; Rilee, M. L.; Curtis, S. A.; Bailin, S.

2012-03-01

We are developing Frontier, a highly adaptable, stably reconfigurable, web-accessible intelligent decision engine capable of optimizing design as well as the simulating operation of complex systems in response to evolving needs and environment.

Understanding India, globalisation and health care systems: a mapping of research in the social sciences

PubMed Central

2012-01-01

National and transnational health care systems are rapidly evolving with current processes of globalisation. What is the contribution of the social sciences to an understanding of this field? A structured scoping exercise was conducted to identify relevant literature using the lens of India – a ‘rising power’ with a rapidly expanding healthcare economy. A five step search and analysis method was employed in order to capture as wide a range of material as possible. Documents published in English that met criteria for a social science contribution were included for review. Via electronic bibliographic databases, websites and hand searches conducted in India, 113 relevant articles, books and reports were identified. These were classified according to topic area, publication date, disciplinary perspective, genre, and theoretical and methodological approaches. Topic areas were identified initially through an inductive approach, then rationalised into seven broad themes. Transnational consumption of health services; the transnational healthcare workforce; the production, consumption and trade in specific health-related commodities, and transnational diffusion of ideas and knowledge have all received attention from social scientists in work related to India. Other themes with smaller volumes of work include new global health governance issues and structures; transnational delivery of health services and the transnational movement of capital. Thirteen disciplines were found represented in our review, with social policy being a clear leader, followed by economics and management studies. Overall this survey of India-related work suggests a young and expanding literature, although hampered by inadequacies in global comparative data, and by difficulties in accessing commercially sensitive information. The field would benefit from further cross-fertilisation between disciplines and greater application of explanatory theory. Literatures around stem cell research and health related commodities provide some excellent examples of illuminating social science. Future research agendas on health systems issues need to include innovative empirical work that captures the dynamics of transnational processes and that links macro-level change to fine-grained observations of social life. PMID:22963264

Understanding India, globalisation and health care systems: a mapping of research in the social sciences.

PubMed

Bisht, Ramila; Pitchforth, Emma; Murray, Susan F

2012-09-10

National and transnational health care systems are rapidly evolving with current processes of globalisation. What is the contribution of the social sciences to an understanding of this field? A structured scoping exercise was conducted to identify relevant literature using the lens of India - a 'rising power' with a rapidly expanding healthcare economy. A five step search and analysis method was employed in order to capture as wide a range of material as possible. Documents published in English that met criteria for a social science contribution were included for review. Via electronic bibliographic databases, websites and hand searches conducted in India, 113 relevant articles, books and reports were identified. These were classified according to topic area, publication date, disciplinary perspective, genre, and theoretical and methodological approaches. Topic areas were identified initially through an inductive approach, then rationalised into seven broad themes. Transnational consumption of health services; the transnational healthcare workforce; the production, consumption and trade in specific health-related commodities, and transnational diffusion of ideas and knowledge have all received attention from social scientists in work related to India. Other themes with smaller volumes of work include new global health governance issues and structures; transnational delivery of health services and the transnational movement of capital. Thirteen disciplines were found represented in our review, with social policy being a clear leader, followed by economics and management studies. Overall this survey of India-related work suggests a young and expanding literature, although hampered by inadequacies in global comparative data, and by difficulties in accessing commercially sensitive information. The field would benefit from further cross-fertilisation between disciplines and greater application of explanatory theory. Literatures around stem cell research and health related commodities provide some excellent examples of illuminating social science. Future research agendas on health systems issues need to include innovative empirical work that captures the dynamics of transnational processes and that links macro-level change to fine-grained observations of social life.

Evolution in thermodynamics

NASA Astrophysics Data System (ADS)

Bejan, Adrian

2017-03-01

This review covers two aspects of "evolution" in thermodynamics. First, with the constructal law, thermodynamics is becoming the domain of physics that accounts for the phenomenon of evolution in nature, in general. Second, thermodynamics (and science generally) is the evolving add-on that empowers humans to predict the future and move more easily on earth, farther and longer in time. The part of nature that thermodynamics represents is this: nothing moves by itself unless it is driven by power, which is then destroyed (dissipated) during movement. Nothing evolves unless it flows and has the freedom to change its architecture such that it provides greater and easier access to the available space. Thermodynamics is the modern science of heat and work and their usefulness, which comes from converting the work (power) into movement (life) in flow architectures that evolve over time to facilitate movement. I also review the rich history of the science, and I clarify misconceptions regarding the second law, entropy, disorder, and the arrow of time, and the supposed analogy between heat and work.

Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment

EPA Science Inventory

Background: Computational exposure science represents a frontier of environmental science that is emerging and quickly evolving.Objectives: In this commentary, we define this burgeoning discipline, describe a framework for implementation, and review some key ongoing research elem...

Planetary Science Training for NASA's Astronauts: Preparing for Future Human Planetary Exploration

NASA Astrophysics Data System (ADS)

Bleacher, J. E.; Evans, C. A.; Graff, T. G.; Young, K. E.; Zeigler, R.

2017-02-01

Astronauts selected in 2017 and in future years will carry out in situ planetary science research during exploration of the solar system. Training to enable this goal is underway and is flexible to accommodate an evolving planetary science vision.

Understanding and Affecting Science Teacher Candidates' Scientific Reasoning in Introductory Astrophysics

ERIC Educational Resources Information Center

Steinberg, Richard; Cormier, Sebastien

2013-01-01

This study reports on a content course for science immersion teacher candidates that emphasized authentic practice of science and thinking scientifically in the context of introductory astrophysics. We explore how 122 science teacher candidates spanning three cohorts did and did not reason scientifically and how this evolved in our program. Our…

Virtual Genomes in Flux: An Interplay of Neutrality and Adaptability Explains Genome Expansion and Streamlining

PubMed Central

Cuypers, Thomas D.; Hogeweg, Paulien

2012-01-01

The picture that emerges from phylogenetic gene content reconstructions is that genomes evolve in a dynamic pattern of rapid expansion and gradual streamlining. Ancestral organisms have been estimated to possess remarkably rich gene complements, although gene loss is a driving force in subsequent lineage adaptation and diversification. Here, we study genome dynamics in a model of virtual cells evolving to maintain homeostasis. We observe a pattern of an initial rapid expansion of the genome and a prolonged phase of mutational load reduction. Generally, load reduction is achieved by the deletion of redundant genes, generating a streamlining pattern. Load reduction can also occur as a result of the generation of highly neutral genomic regions. These regions can expand and contract in a neutral fashion. Our study suggests that genome expansion and streamlining are generic patterns of evolving systems. We propose that the complex genotype to phenotype mapping in virtual cells as well as in their biological counterparts drives genome size dynamics, due to an emerging interplay between adaptation, neutrality, and evolvability. PMID:22234601

Progress toward Modular UAS for Geoscience Applications

NASA Astrophysics Data System (ADS)

Dahlgren, R. P.; Clark, M. A.; Comstock, R. J.; Fladeland, M.; Gascot, H., III; Haig, T. H.; Lam, S. J.; Mazhari, A. A.; Palomares, R. R.; Pinsker, E. A.; Prathipati, R. T.; Sagaga, J.; Thurling, J. S.; Travers, S. V.

2017-12-01

Small Unmanned Aerial Systems (UAS) have become accepted tools for geoscience, ecology, agriculture, disaster response, land management, and industry. A variety of consumer UAS options exist as science and engineering payload platforms, but their incompatibilities with one another contribute to high operational costs compared with those of piloted aircraft. This research explores the concept of modular UAS, demonstrating airframes that can be reconfigured in the field for experimental optimization, to enable multi-mission support, facilitate rapid repair, or respond to changing field conditions. Modular UAS is revolutionary in allowing aircraft to be optimized around the payload, reversing the conventional wisdom of designing the payload to accommodate an unmodifiable aircraft. UAS that are reconfigurable like Legos™ are ideal for airborne science service providers, system integrators, instrument designers and end users to fulfill a wide range of geoscience experiments. Modular UAS facilitate the adoption of open-source software and rapid prototyping technology where design reuse is important in the context of a highly regulated industry like aerospace. The industry is now at a stage where consolidation, acquisition, and attrition will reduce the number of small manufacturers, with a reduction of innovation and motivation to reduce costs. Modularity leads to interface specifications, which can evolve into de facto or formal standards which contain minimum (but sufficient) details such that multiple vendors can then design to those standards and demonstrate interoperability. At that stage, vendor coopetition leads to robust interface standards, interoperability standards and multi-source agreements which in turn drive costs down significantly.

The Nomad Explorer assembly assist vehicle: An architecture for rapid global extraterrestrial base infrastructure establishment

NASA Technical Reports Server (NTRS)

Thangavelu, Madhu

1994-01-01

Traditional concepts of lunar bases describe scenarios where components of the bases are landed on the lunar surface, one at a time, and then put together to form a complete stationary lunar habitat. Recently, some concepts have described the advantages of operating a mobile or 'roving' lunar base. Such a base vastly improves the exploration range from a primary lunar base. Roving bases would also allow the crew to first deploy, test, operationally certify, and then regularly maintain, service, and evolve long life-cycle facilities like observatories or other science payload platforms that are operated far apart from each other across the extraterrestrial surface. The Nomad Explorer is such a mobile lunar base. This paper describes the architectural program of the Nomad Explorer, its advantages over a stationary lunar base, and some of the embedded system concepts which help the roving base to speedily establish a global extraterrestrial infrastructure. A number of modular autonomous logistics landers will carry deployable or erectable payloads, service, and logistically resupply the Nomad Explorer at regular intercepts along the traverse. Starting with the deployment of science experiments and telecommunication networks, and the manned emplacement of a variety of remote outposts using a unique EVA Bell system that enhances manned EVA, the Nomad Explorer architecture suggests the capability for a rapid global development of the extraterrestrial body. The Moon and Mars are candidates for this 'mission oriented' strategy. The lunar case is emphasized in this paper.

Digital Direct-to-Consumer Advertising: A Perfect Storm of Rapid Evolution and Stagnant Regulation Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters".

PubMed

Mackey, Tim K

2016-02-03

The adoption and use of digital forms of direct-to-consumer advertising (also known as "eDTCA") is on the rise. At the same time, the universe of eDTCA is expanding, as technology on Internet-based platforms continues to evolve, from static websites, to social media, and nearly ubiquitous use of mobile devices. However, little is known about how this unique form of pharmaceutical marketing impacts consumer behavior, public health, and overall healthcare utilization. The study by Kim analyzing US Food and Drug Administration (FDA) notices of violations (NOVs) and warning letters regarding online promotional activities takes us in the right direction, but study results raise as many questions as it does answers. Chief among these are unanswered concerns about the unique regulatory challenges posed by the "disruptive" qualities of eDTCA, and whether regulators have sufficient resources and oversight powers to proactively address potential violations. Further, the globalization of eDTCA via borderless Internet-based technologies raises larger concerns about the potential global impact of this form of health marketing unique to only the United States and New Zealand. Collectively, these challenges make it unlikely that regulatory science will be able to keep apace with the continued rapid evolution of eDTCA unless more creative policy solutions are explored. © 2016 by Kerman University of Medical Sciences.

CONNECTIVITY OF ENVIRONMENT, HUMAN HEALTH AND SOCIOECONOMICS: IMPLICATIONS FOR SCIENCE AND POLICY

EPA Science Inventory

Environmental and public health policy continues to evolve in response to new and complex social, economic and environmental drivers. Globalization of commerce, evolving patterns of land use, and technological advances in such areas as manufacturing and genetically modified food...

A Rapid Prototyping Look at NASA's Next Generation Earth-Observing Satellites; Opportunities for Global Change Research and Applications

NASA Astrophysics Data System (ADS)

Cecil, L.; Young, D. F.; Parker, P. A.; Eckman, R. S.

2006-12-01

The NASA Applied Sciences Program extends the results of Earth Science Division (ESD) research and knowledge beyond the scientific and research communities to contribute to national priority applications with societal benefits. The Applied Sciences Program focuses on, (1) assimilation of NASA Earth-science research results and their associated uncertainties to improve decision support systems and, (2) the transition of NASA research results to evolve improvements in future operational systems. The broad range of Earth- science research results that serve as inputs to the Applied Sciences Program are from NASA's Research and Analysis Program (R&A) within the ESD. The R&A Program has established six research focus areas to study the complex processes associated with Earth-system science; Atmospheric Composition, Carbon Cycle and Ecosystems, Climate Variability and Change, Earth Surface and Interior, Water and Energy Cycle, and Weather. Through observations-based Earth-science research results, NASA and its partners are establishing predictive capabilities for future projections of natural and human perturbations on the planet. The focus of this presentation is on the use of research results and their associated uncertainties from several of NASA's nine next generation missions for societal benefit. The newly launched missions are, (1) CloudSat, and (2) CALIPSO (Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observations), both launched April 28, 2006, and the planned next generation missions include, (3) the Orbiting Carbon Observatory (OCO), (4) the Global Precipitation Mission (GPM), (5) the Landsat Data Continuity Mission (LDCM), (6) Glory, for measuring the spatial and temporal distribution of aerosols and total solar irradiance for long-term climate records, (7) Aquarius, for measuring global sea surface salinity, (8) the Ocean Surface Topography Mission (OSTM), and (9) the NPOESS Preparatory Project (NPP) for measuring long-term climate trends and global biological productivity. NASA's Applied Sciences Program is taking a scientifically rigorous systems engineering approach to facilitate rapid prototyping of potential uses of the projected research capabilities of these new missions into decision support systems. This presentation includes an example of a prototype experiment that focuses on two of the Applied Sciences Program's twelve National Applications focus areas, Water Management and Energy Management. This experiment is utilizing research results and associated uncertainties from existing Earth-observation missions as well as from several of NASA's nine next generation missions. This prototype experiment is simulating decision support analysis and research results leading to priority management and/or policy issues concentrating on climate change and uncertainties in alpine areas on the watershed scale.

A review of astronomical science with visible light adaptive optics

NASA Astrophysics Data System (ADS)

Close, Laird M.

2016-07-01

We review astronomical results in the visible (λ<1μm) with adaptive optics. Other than a brief period in the early 1990s, there has been little (<1 paper/yr) night-time astronomical science published with AO in the visible from 2000-2013 (outside of the solar or Space Surveillance Astronomy communities where visible AO is the norm, but not the topic of this invited review). However, since mid-2013 there has been a rapid increase visible AO with over 50 refereed science papers published in just 2.5 years (visible AO is experiencing a rapid growth rate very similar to that of NIR AO science from 1997-2000 Close 2000). Currently the most productive small (D < 2 m) visible light AO telescope is the UV-LGS Robo-AO system (Baranec, et al. 2016) on the robotic Palomar D=1.5 m telescope (currently relocated to the Kitt Peak 1.8m; Salama et al. 2016). Robo-AO uniquely offers the ability to target >15 objects/hr, which has enabled large (>3000 discrete targets) companion star surveys and has resulted in 23 refereed science publications. The most productive large telescope visible AO system is the D=6.5m Magellan telescope AO system (MagAO). MagAO is an advanced Adaptive Secondary Mirror (ASM) AO system at the Magellan 6.5m in Chile (Morzinski et al. 2016). This ASM secondary has 585 actuators with < 1 msec response times (0.7 ms typically). MagAO utilizes a 1 kHz pyramid wavefront sensor. The relatively small actuator pitch ( 22 cm/subap) allows moderate Strehls to be obtained in the visible (0.63-1.05 microns). Long exposures (60s) achieve <30mas resolutions, 30% Strehls at 0.62 microns (r') with the VisAO camera in 0.5" seeing with bright R <= 9 mag stars. These capabilities have led to over 22 MagAO refereed science publications in the visible. The largest (D=8m) telescope to achieve regular visible AO science is SPHERE/ZIMPOL. ZIMPOL is a polarimeter fed by the 1.2 kHz SPHERE ExAO system (Fusco et al. 2016). ZIMPOL's ability to differentiate scattered polarized light from starlight allows the sensitive detection of circumstellar disks, stellar surfaces, and envelopes of evolved AGB stars. Here we review the key steps to having good performance in the visible and review the exciting new AO visible science opportunities and science results in the fields of: exoplanet detection; circumstellar and protoplanetary disks; young stars; AGB stars; emission line jets; and stellar surfaces. The recent rapid increase in the scientific publications and power of visible AO is due to the maturity of the next-generation of AO systems and our new ability probe circumstellar regions with very high (10-30 mas) spatial resolutions that would otherwise require much larger (>10m) diameter telescopes in the infrared.

Developing the Inner Scientist: Book Club Participation and the Nature of Science

ERIC Educational Resources Information Center

Griffard, Phyllis Baudoin; Mosleh, Tayseer; Kubba, Saad

2013-01-01

The leap from science student to scientist involves recognizing that science is a tentative, evolving body of knowledge that is socially constructed and culturally influenced; this is known as The Nature of Science (NOS). The aim of this study was to document NOS growth in first-year premedical students who participated in a science book club as a…

Curriculum evaluation and revision in a nascent field: the utility of the retrospective pretest--posttest model in a homeland security program of study.

PubMed

Pelfrey, William V; Pelfrey, William V

2009-02-01

Although most academic disciplines evolve at a measured pace, the emerging field of homeland security must, for reasons of safety and security, evolve rapidly. The Department of Homeland Security sponsored the establishment of a graduate educational program for key officials holding homeland security roles. Because homeland security is a nascent field, the establishment of a program curriculum was forced to draw from a variety of disciplines. Curriculum evaluation was complicated by the rapid changes occurring in the emerging discipline, producing response shift bias, and interfering with the pre-post assessments. To compensate for the validity threat associated with response shift bias, a retrospective pretest-posttest evaluative methodology was used. Data indicate the program has evolved in a significant and orderly fashion and these data support the use of this innovative evaluation approach in the development of any discipline.

A systems approach to bone pathophysiology.

PubMed

Weiss, Aaron J; Lipshtat, Azi; Mechanick, Jeffrey I

2010-11-01

With evolving interest in multiscalar biological systems one could assume that reductionist approaches may not fully describe biological complexity. Instead, tools such as mathematical modeling, network analysis, and other multiplexed clinical- and research-oriented tests enable rapid analyses of high-throughput data parsed at the genomic, proteomic, metabolomic, and physiomic levels. A physiomic-level approach allows for recursive horizontal and vertical integration of subsystem coupling across and within spatiotemporal scales. Additionally, this methodology recognizes previously ignored subsystems and the strong, nonintuitively obvious and indirect connections among physiological events that potentially account for the uncertainties in medicine. In this review, we flip the reductionist research paradigm and review the concept of systems biology and its applications to bone pathophysiology. Specifically, a bone-centric physiome model is presented that incorporates systemic-level processes with their respective therapeutic implications. © 2010 New York Academy of Sciences.

The Use of Proteomics in Assisted Reproduction.

PubMed

Kosteria, Ioanna; Anagnostopoulos, Athanasios K; Kanaka-Gantenbein, Christina; Chrousos, George P; Tsangaris, George T

2017-01-01

Despite the explosive increase in the use of Assisted Reproductive Technologies (ART) over the last 30 years, their success rates remain suboptimal. Proteomics is a rapidly-evolving technology-driven science that has already been widely applied in the exploration of human reproduction and fertility, providing useful insights into its physiology and leading to the identification of numerous proteins that may be potential biomarkers and/or treatment targets of a successful ART pregnancy. Here we present a brief overview of the techniques used in proteomic analyses and attempt a comprehensive presentation of recent data from mass spectrometry-based proteomic studies in humans, regarding all components of ARTs, including the male and female gamete, the derived zygote and embryo, the endometrium and, finally, the ART offspring both pre- and postnatally. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Reviewing social media use by clinicians.

PubMed

von Muhlen, Marcio; Ohno-Machado, Lucila

2012-01-01

Adoption studies of social media use by clinicians were systematically reviewed, up to July 26th, 2011, to determine the extent of adoption and highlight trends in institutional responses. This search led to 370 articles, of which 50 were selected for review, including 15 adoption surveys. The definition of social media is evolving rapidly; the authors define it broadly to include social networks and group-curated reference sites such as Wikipedia. Facebook accounts are very common among health science students (64-96%) and less so for professional clinicians (13-47%). Adoption rates have increased sharply in the past 4 years. Wikipedia is widely used as a reference tool. Attempts at incorporating social media into clinical training have met with mixed success. Posting of unprofessional content and breaches of patient confidentiality, especially by students, are not uncommon and have prompted calls for social media guidelines.

Electric light causes cancer? Surely you're joking, Mr. Stevens.

PubMed

Stevens, Richard G

2009-01-01

Night is no longer dark in the modern world, and the Milky Way has disappeared. Electric light has benefits but there are also a few detriments. These are (1) loss of the night sky, (2) wasted energy, (3) harm to animal and plant life, (4) and perhaps increases in some severe human maladies such as cancers of breast and prostate. The science on phototransduction for the circadian system and on clock gene function is evolving rapidly, and it provides a rationale for the idea that circadian disruption from light at night could cause disease. Direct evidence from humans and rodent models has also accumulated to the point where the idea is no longer fanciful. Although it may seem logical now, the journey on the path from electric light to breast cancer has been a tortuous one, at least for me.

Rapid evolution accelerates plant population spread in fragmented experimental landscapes.

PubMed

Williams, Jennifer L; Kendall, Bruce E; Levine, Jonathan M

2016-07-29

Predicting the speed of biological invasions and native species migrations requires an understanding of the ecological and evolutionary dynamics of spreading populations. Theory predicts that evolution can accelerate species' spread velocity, but how landscape patchiness--an important control over traits under selection--influences this process is unknown. We manipulated the response to selection in populations of a model plant species spreading through replicated experimental landscapes of varying patchiness. After six generations of change, evolving populations spread 11% farther than nonevolving populations in continuously favorable landscapes and 200% farther in the most fragmented landscapes. The greater effect of evolution on spread in patchier landscapes was consistent with the evolution of dispersal and competitive ability. Accounting for evolutionary change may be critical when predicting the velocity of range expansions. Copyright © 2016, American Association for the Advancement of Science.

EVOLUTION. Fruit flies diversify their offspring in response to parasite infection.

PubMed

Singh, Nadia D; Criscoe, Dallas R; Skolfield, Shelly; Kohl, Kathryn P; Keebaugh, Erin S; Schlenke, Todd A

2015-08-14

The evolution of sexual reproduction is often explained by Red Queen dynamics: Organisms must continually evolve to maintain fitness relative to interacting organisms, such as parasites. Recombination accompanies sexual reproduction and helps diversify an organism's offspring, so that parasites cannot exploit static host genotypes. Here we show that Drosophila melanogaster plastically increases the production of recombinant offspring after infection. The response is consistent across genetic backgrounds, developmental stages, and parasite types but is not induced after sterile wounding. Furthermore, the response appears to be driven by transmission distortion rather than increased recombination. Our study extends the Red Queen model to include the increased production of recombinant offspring and uncovers a remarkable ability of hosts to actively distort their recombination fraction in rapid response to environmental cues. Copyright © 2015, American Association for the Advancement of Science.

The current social, political, and medical role of genetic testing in familial breast and ovarian carcinomas.

PubMed

Weitzel, J N

1999-02-01

Few advances in medical science have yielded as much publicity and controversy as discoveries in genetics. Moving quickly from the bench to the bedside, genetic testing for inherited susceptibility to breast and ovarian cancer has had a significant impact on our paradigms for decisions about the treatment and prevention of disease. Assessment of cancer risk is developing into a distinct discipline, with rapidly evolving genetic technologies and models for estimating an individual's risk of cancer. Exciting developments in chemoprevention of breast cancer demonstrate the potential to offer a broader range of options for decreasing cancer risk. This article will consider recent advances in the understanding of cancer genetics, and describe the state-of-the-art in terms of management of individuals with inherited susceptibility to breast and ovarian cancer.

[Applied ecology: retrospect and prospect].

PubMed

He, Xingyuan; Zeng, Dehui

2004-10-01

Applied ecology is evolved into a principal part of modern ecology that rapidly develops. The major stimulus for the development of applied ecology roots in seeking the solutions for the problems of human populations, resources and environments. Through four decades, the science of applied ecology has been becoming a huge group of disciplines. The future for the applied ecology should concern more with human-influenced and managed ecosystems, and acknowledge humans as the components of ecosystems. Nowadays and in future, the top-priorities in applied ecology should include following fields: sustainable ecosystems and biosphere, ecosystem services and ecological design, ecological assessment of genetically modified organisms, ecology of biological invasions, epidemical ecology, ecological forecasting, ecological process and its control. The authors believe that the comprehensive and active research hotspots coupled some new traits would occur around these fields in foreseeable future.

Frequency of word-use predicts rates of lexical evolution throughout Indo-European history.

PubMed

Pagel, Mark; Atkinson, Quentin D; Meade, Andrew

2007-10-11

Greek speakers say "omicronupsilonrho", Germans "schwanz" and the French "queue" to describe what English speakers call a 'tail', but all of these languages use a related form of 'two' to describe the number after one. Among more than 100 Indo-European languages and dialects, the words for some meanings (such as 'tail') evolve rapidly, being expressed across languages by dozens of unrelated words, while others evolve much more slowly--such as the number 'two', for which all Indo-European language speakers use the same related word-form. No general linguistic mechanism has been advanced to explain this striking variation in rates of lexical replacement among meanings. Here we use four large and divergent language corpora (English, Spanish, Russian and Greek) and a comparative database of 200 fundamental vocabulary meanings in 87 Indo-European languages to show that the frequency with which these words are used in modern language predicts their rate of replacement over thousands of years of Indo-European language evolution. Across all 200 meanings, frequently used words evolve at slower rates and infrequently used words evolve more rapidly. This relationship holds separately and identically across parts of speech for each of the four language corpora, and accounts for approximately 50% of the variation in historical rates of lexical replacement. We propose that the frequency with which specific words are used in everyday language exerts a general and law-like influence on their rates of evolution. Our findings are consistent with social models of word change that emphasize the role of selection, and suggest that owing to the ways that humans use language, some words will evolve slowly and others rapidly across all languages.

Is Computer Science Compatible with Technological Literacy?

ERIC Educational Resources Information Center

Buckler, Chris; Koperski, Kevin; Loveland, Thomas R.

2018-01-01

Although technology education evolved over time, and pressure increased to infuse more engineering principles and increase links to STEM (science technology, engineering, and mathematics) initiatives, there has never been an official alignment between technology and engineering education and computer science. There is movement at the federal level…

Computer Simulation in Social Science.

ERIC Educational Resources Information Center

Garson, G. David

From a base in military models, computer simulation has evolved to provide a wide variety of applications in social science. General purpose simulation packages and languages such as FIRM, DYNAMO, and others have made significant contributions toward policy discussion in the social sciences and have well-documented efficacy in instructional…

High Hopes--Few Opportunities: The Status of Elementary Science Education in California. Strengthening Science Education in California

ERIC Educational Resources Information Center

Dorph, R.; Shields, P.; Tiffany-Morales, J.; Hartry, A.; McCaffrey, T.

2011-01-01

This report addresses how well California is doing to prepare its young people for the evolving economy and societal challenges. Specifically, it describes the status of science teaching and learning in California public elementary schools. This study was conducted in support of "Strengthening Science Education in California," a…

Are We Really the Prey? Nanotechnology as Science and Science Fiction

ERIC Educational Resources Information Center

Bowman, Diana M.; Hodge, Graeme A.; Binks, Peter

2007-01-01

Popular culture can play a significant role in shaping the acceptance of evolving technologies, with nanotechnology likely to be a case in point. The most popular fiction work to date in this arena has been Michael Crichton's techno-thriller "Prey," which fuses together nanotechnology science with science fiction. Within the context of "Prey,"…

Psychology as an Evolving, Interdisciplinary Science: Integrating Science in Sensation and Perception from Fourier to Fluid Dynamics

ERIC Educational Resources Information Center

Ebersole, Tela M.; Kelty-Stephen, Damian G.

2017-01-01

This article outlines the theoretical rationale and process for an integrated-science approach to teaching sensation and perception (S&P) to undergraduate psychology students that may also serve as an integrated-science curriculum. The course aimed to introduce the interdisciplinary evolution of this psychological field irrespective of any…

Multi-Stage Open Peer Review: Scientific Evaluation Integrating the Strengths of Traditional Peer Review with the Virtues of Transparency and Self-Regulation

PubMed Central

Pöschl, Ulrich

2012-01-01

The traditional forms of scientific publishing and peer review do not live up to all demands of efficient communication and quality assurance in today’s highly diverse and rapidly evolving world of science. They need to be advanced and complemented by interactive and transparent forms of review, publication, and discussion that are open to the scientific community and to the public. The advantages of open access, public peer review, and interactive discussion can be efficiently and flexibly combined with the strengths of traditional scientific peer review. Since 2001 the benefits and viability of this approach are clearly demonstrated by the highly successful interactive open access journal Atmospheric Chemistry and Physics (ACP, www.atmos-chem-phys.net) and a growing number of sister journals launched and operated by the European Geosciences Union (EGU, www.egu.eu) and the open access publisher Copernicus (www.copernicus.org). The interactive open access journals are practicing an integrative multi-stage process of publication and peer review combined with interactive public discussion, which effectively resolves the dilemma between rapid scientific exchange and thorough quality assurance. Key features and achievements of this approach are: top quality and impact, efficient self-regulation and low rejection rates, high attractivity and rapid growth, low costs, and financial sustainability. In fact, ACP and the EGU interactive open access sister journals are by most if not all standards more successful than comparable scientific journals with traditional or alternative forms of peer review (editorial statistics, publication statistics, citation statistics, economic costs, and sustainability). The high efficiency and predictive validity of multi-stage open peer review have been confirmed in a series of dedicated studies by evaluation experts from the social sciences, and the same or similar concepts have recently also been adopted in other disciplines, including the life sciences and economics. Multi-stage open peer review can be flexibly adjusted to the needs and peculiarities of different scientific communities. Due to the flexibility and compatibility with traditional structures of scientific publishing and peer review, the multi-stage open peer review concept enables efficient evolution in scientific communication and quality assurance. It has the potential for swift replacement of hidden peer review as the standard of scientific quality assurance, and it provides a basis for open evaluation in science. PMID:22783183

MESSENGER Observations of Rapid and Impulsive Magnetic Reconnection in Mercury's Magnetotail

NASA Astrophysics Data System (ADS)

Zhong, J.; Wei, Y.; Pu, Z. Y.; Wang, X. G.; Wan, W. X.; Slavin, J. A.; Cao, X.; Raines, J. M.; Zhang, H.; Xiao, C. J.; Du, A. M.; Wang, R. S.; Dewey, R. M.; Chai, L. H.; Rong, Z. J.; Li, Y.

2018-06-01

The nature of magnetic reconnection in planetary magnetospheres may differ between various planets. We report the first observations of a rapidly evolving magnetic reconnection process in Mercury’s magnetotail by the MESSENGER spacecraft. The reconnection process was initialized in the plasma sheet and then evolved into the lobe region during a ∼35 s period. The tailward reconnection fronts of primary and secondary flux ropes with clear Hall signatures and energetic electron bursts were observed. The reconnection timescale of a few seconds is substantially shorter than that of terrestrial magnetospheric plasmas. The normalized reconnection rate during a brief quasi-steady period is estimated to be ∼0.2 on average. The observations show the rapid and impulsive nature of the exceedingly driven reconnection in Mercury’s magnetospheric plasma that may be responsible for the much more dynamic magnetosphere of Mercury.

The Current Status of Instructional Design Theories in Relation to Today's Authoring Systems

ERIC Educational Resources Information Center

O'Neil, A. Fred

2008-01-01

It is of course very difficult to accurately project important characteristics of the future state of any rapidly evolving field, and the field of authoring systems for computer-assisted instruction (CAI) is no exception. However, strong trends in evolving CAI systems of today would seem to indicate some important characteristics of the software…

A Conceptual Framework for Evolving, Recommender Online Learning Systems

ERIC Educational Resources Information Center

Peiris, K. Dharini Amitha; Gallupe, R. Brent

2012-01-01

A comprehensive conceptual framework is developed and described for evolving recommender-driven online learning systems (ROLS). This framework describes how such systems can support students, course authors, course instructors, systems administrators, and policy makers in developing and using these ROLS. The design science information systems…

Literature, Science, and Cooking in the Primary Grades.

ERIC Educational Resources Information Center

Donoghue, Mildred R.

Since the balanced literacy program presently mandated in California makes literature an integral part of the curriculum and leaves even less time for study of the sciences, this annotated bibliography provides some recommended literature together with the science concepts that evolve from those books. The bibliography also offers cooking recipes…

Science, Evolution, and Creationism

ERIC Educational Resources Information Center

National Academies Press, 2008

2008-01-01

How did life evolve on Earth? The answer to this question can help us understand our past and prepare for our future. Although evolution provides credible and reliable answers, polls show that many people turn away from science, seeking other explanations with which they are more comfortable. In the book "Science, Evolution, and…

Stakeholder analysis: a review.

PubMed

Brugha, R; Varvasovszky, Z

2000-09-01

The growing popularity of stakeholder analysis reflects an increasing recognition of how the characteristics of stakeholders--individuals, groups and organizations--influence decision-making processes. This paper reviews the origins and uses of stakeholder analysis, as described in the policy, health care management and development literature. Its roots are in the political and policy sciences, and in management theory where it has evolved into a systematic tool with clearly defined steps and applications for scanning the current and future organizational environment. Stakeholder analysis can be used to generate knowledge about the relevant actors so as to understand their behaviour, intentions, interrelations, agendas, interests, and the influence or resources they have brought--or could bring--to bear on decision-making processes. This information can then be used to develop strategies for managing these stakeholders, to facilitate the implementation of specific decisions or organizational objectives, or to understand the policy context and assess the feasibility of future policy directions. Policy development is a complex process which frequently takes place in an unstable and rapidly changing context, subject to unpredictable internal and external factors. As a cross-sectional view of an evolving picture, the utility of stakeholder analysis for predicting and managing the future is time-limited and it should be complemented by other policy analysis approaches.

Electronic nicotine delivery devices, and their impact on health and patterns of tobacco use: a systematic review protocol

PubMed Central

Glasser, Allison M; Cobb, Caroline O; Teplitskaya, Lyubov; Ganz, Ollie; Katz, Lauren; Rose, Shyanika W; Feirman, Shari; Villanti, Andrea C

2015-01-01

Introduction E-cigarettes or electronic nicotine delivery systems (ENDS) have recently attracted considerable attention. Among some individuals there is strong debate and a polarisation of views about the public health benefits versus harms of ENDS. With little regulation, the ENDS market is evolving, and new products are introduced and marketed constantly. Rapid developments in manufacturing, marketing and consumer domains related to ENDS will warrant frequent re-evaluation, based on the state of the evolving science. The purpose of this article is to describe a protocol for an ongoing comprehensive review of the published scientific literature on ENDS. Methods and analysis We will undertake a systematic review of published empirical research literature on ENDS using the National Library of Medicine's PubMed electronic database to search for relevant articles. Data from included studies will be extracted into a standardised form, tables with study details and key outcomes for each article will be created, and studies will be synthesised qualitatively. Ethics and dissemination This review synthesises published literature and presents no primary data. Therefore, no ethical approval is required for this study. Subsequent papers will provide greater detail on results, within select categories, that represent gaps in the literature base. PMID:25926149

Are evolutionary hypotheses for motion sickness "just-so" stories?

PubMed

Oman, Charles M

2012-01-01

Vertebrates have evolved rapidly conditionable nausea and vomiting reflexes mediated by gut and brainstem receptors, clearly as a defense against neurotoxin ingestion. In 1977 Treisman proposed that sensory orientation linkages to emetic centers evolved for the same reason, and that motion sickness was an accidental byproduct. It was an "adaptationist" explanation for motion sickness, since it assumed that evolution has shaped all phenotypic traits for survival advantage. Treisman's "poison" theory is plausible, and frequently cited as the accepted scientific explanation for motion sickness. However, alternative explanations have been proposed. The creation of hypotheses is an essential part of science - provided they are testable. This paper reviews the evidence for the Poison theory and several other adaptationist explanations. These hypotheses are certainly not "just-so stories", but supporting evidence is equivocal, and contradictory evidence exists Parsimony suggests an alternative "pluralistic" view: The vertebrate reticular formation maintains oxygenated blood flow to the brain, discriminates unexpected sensory stimuli- including postural disturbances, and detects and expels ingested neurotoxins. The three systems share neuroarchitectural elements but normally function independently. Brainstem sensory conflict neurons normally discriminate brief postural disturbances, but can be abnormally stimulated during prolonged passive transport (e.g. by boat, beginning about 150-200 generations ago). Sensory conflict signals cross couple into the neurotoxin expulsion and avoidance system, producing an arguably maladaptive emetic phenotype.

Colorado Students Head to National Science Competition

Science.gov Websites

question and answer tournament that focuses on physics, math, biology, astronomy, chemistry, computers and nine years ago to help stimulate interest in science and math. The competition has evolved into one of

Do I Really Sound Like That? Communicating Earthquake Science Following Significant Earthquakes at the NEIC

NASA Astrophysics Data System (ADS)

Hayes, G. P.; Earle, P. S.; Benz, H.; Wald, D. J.; Yeck, W. L.

2017-12-01

The U.S. Geological Survey's National Earthquake Information Center (NEIC) responds to about 160 magnitude 6.0 and larger earthquakes every year and is regularly inundated with information requests following earthquakes that cause significant impact. These requests often start within minutes after the shaking occurs and come from a wide user base including the general public, media, emergency managers, and government officials. Over the past several years, the NEIC's earthquake response has evolved its communications strategy to meet the changing needs of users and the evolving media landscape. The NEIC produces a cascade of products starting with basic hypocentral parameters and culminating with estimates of fatalities and economic loss. We speed the delivery of content by prepositioning and automatically generating products such as, aftershock plots, regional tectonic summaries, maps of historical seismicity, and event summary posters. Our goal is to have information immediately available so we can quickly address the response needs of a particular event or sequence. This information is distributed to hundreds of thousands of users through social media, email alerts, programmatic data feeds, and webpages. Many of our products are included in event summary posters that can be downloaded and printed for local display. After significant earthquakes, keeping up with direct inquiries and interview requests from TV, radio, and print reports is always challenging. The NEIC works with the USGS Office of Communications and the USGS Science Information Services to organize and respond to these requests. Written executive summaries reports are produced and distributed to USGS personnel and collaborators throughout the country. These reports are updated during the response to keep our message consistent and information up to date. This presentation will focus on communications during NEIC's rapid earthquake response but will also touch on the broader USGS traditional and social media presence.

Rapid response systems.

PubMed

Lyons, Patrick G; Edelson, Dana P; Churpek, Matthew M

2018-07-01

Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. We aimed to review the current state of the rapid response literature, including evolving aspects of afferent (risk detection) and efferent (intervention) arms, outcome measurement, process improvement, and implementation. Articles written in English and published in PubMed. Rapid response systems are heterogeneous, with important differences among afferent and efferent arms. Clinically meaningful outcomes may include unexpected mortality, in-hospital cardiac arrest, length of stay, cost, and processes of care at end of life. Both positive and negative interventional studies have been published, although the two largest randomized trials involving rapid response systems - the Medical Early Response and Intervention Trial (MERIT) and the Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients (EPOCH) trial - did not find a mortality benefit with these systems, albeit with important limitations. Advances in monitoring technologies, risk assessment strategies, and behavioral ergonomics may offer opportunities for improvement. Rapid responses may improve some meaningful outcomes, although these findings remain controversial. These systems may also improve care for patients at the end of life. Rapid response systems are expected to continue evolving with novel developments in monitoring technologies, risk prediction informatics, and work in human factors. Copyright © 2018 Elsevier B.V. All rights reserved.

The Implementation and Growth of an International Online Forensic Science Graduate Program at the University of Florida

ERIC Educational Resources Information Center

Grundmann, Oliver; Wielbo, Donna; Tebbett, Ian

2010-01-01

Forensic science education has evolved as an interdisciplinary science that includes medicine, chemistry, biology, and criminal justice. Therefore, multiple paths can lead to a career in forensic science. A formal education usually requires the student to attend a college or university to obtain a bachelor's or master's degree. In many cases,…

Invitations to Evolving. Teacher-Friendly Science Activities with Reproducible Handouts in English and Spanish. Grades 3-5. Living Things Science Series.

ERIC Educational Resources Information Center

Camp, Carole Ann, Ed.

This booklet, one of six in the Living Things Science series, presents activities about evolution which address basic "Benchmarks" suggested by the American Association for the Advancement of Science for the Living Environment for grades 3-5. Contents include background information, vocabulary (in English and Spanish), materials,…

The PACA Project Observing Campaigns: From Comets to the Sun

NASA Astrophysics Data System (ADS)

Yanamandra-Fisher, Padma A.; PACA Project

2017-10-01

The Pro-Am Collaborative Astronomy (PACA) project evolved from the observational campaign of C/2012 S1 or C/ISON in 2013, and has expanded to pro-am observing campaigns of planets, polarimetric exploration and recently, polarization of the inner solar corona during the 2017 US Continental Total Solar Eclipse (TSE). The evolving need for individual customized observing campaigns has been incorporated into the evolution of PACA portal: supporting observing campaigns of current comets, legacy data, historical comets, planets, solar corona, interconnected with social media and a set of shareable documents addressing observational strategies; consistent standards for data; data access, use, and storage, to align with the needs of professional observers. Given the volume of data generated for each campaign, new ways of rapid data analysis, mining access and storage are needed. Several interesting results emerged from the synergistic inclusion of both social media and amateur astronomers: (1) the establishment of a network of astronomers and related professionals, that can be galvanized into action on short notice to support observing campaigns; (2) assist in various science investigations pertinent to the campaign; (3) provide an alert-sounding mechanism should the need arise; (4) immediate outreach and dissemination of results via our media/blogger members; (5) provide a forum for discussions between the imagers and modelers to help strategize the observing campaign for maximum benefit. Some recent PACA campaigns of note are: C/2013 A1 (C/SidingSpring) ; 67P/Churyumov-Gerasimenko (CG), target for ESA/Rosetta mission; PACA_Jupiter (and for other planets Mars, Saturn, Uranus and Neptune); polarimetry and current campaign PACA_PolNet, a multi-site polarimetric network to be implemented in August 2017, in partnership with the project Citizen CATE. I will highlight key aspects of various PACA campaigns, especially the current PACA_PolNet for the 2017 Total Solar Eclipse and the proposed collaboration for the next Total Solar Eclipse of 2024. The integration of science, observations by professional and amateur astronomers, and various social media provides a dynamic and evolving collective collaborative partnership.

The Impact of the 5E Teaching Model on Changes in Neuroscience, Drug Addiction, and Research Methods Knowledge of Science Teachers Attending California's ARISE Professional Development Workshops

ERIC Educational Resources Information Center

Manzo, Rosa D.; Whent, Linda; Liets, Lauren; de la Torre, Adela; Gomez-Camacho, Rosa

2016-01-01

This study examined how science teachers' knowledge of research methods, neuroscience and drug addiction changed through their participation in a 5-day summer science institute. The data for this study evolved from a four-year NIH funded science education project called Addiction Research and Investigation for Science Educators (ARISE). Findings…

Post-Cold War Science and Technology at Los Alamos

NASA Astrophysics Data System (ADS)

Browne, John C.

2002-04-01

Los Alamos National Laboratory serves the nation through the development and application of leading-edge science and technology in support of national security. Our mission supports national security by: ensuring the safety, security, and reliability of the U.S. nuclear stockpile; reducing the threat of weapons of mass destruction in support of counter terrorism and homeland defense; and solving national energy, environment, infrastructure, and health security problems. We require crosscutting fundamental and advanced science and technology research to accomplish our mission. The Stockpile Stewardship Program develops and applies, advanced experimental science, computational simulation, and technology to ensure the safety and reliability of U.S. nuclear weapons in the absence of nuclear testing. This effort in itself is a grand challenge. However, the terrorist attack of September 11, 2001, reminded us of the importance of robust and vibrant research and development capabilities to meet new and evolving threats to our national security. Today through rapid prototyping we are applying new, innovative, science and technology for homeland defense, to address the threats of nuclear, chemical, and biological weapons globally. Synergistically, with the capabilities that we require for our core mission, we contribute in many other areas of scientific endeavor. For example, our Laboratory has been part of the NASA effort on mapping water on the moon and NSF/DOE projects studying high-energy astrophysical phenomena, understanding fundamental scaling phenomena of life, exploring high-temperature superconductors, investigating quantum information systems, applying neutrons to condensed-matter and nuclear physics research, developing large-scale modeling and simulations to understand complex phenomena, and exploring nanoscience that bridges the atomic to macroscopic scales. In this presentation, I will highlight some of these post-cold war science and technology advances including our national security contributions, and discuss some of challenges for Los Alamos in the future.

A story of microalbuminuria and diabetic nephropathy.

PubMed

Roshan, Bijan; Stanton, Robert C

2013-10-01

It is estimated that more than 346 million people worldwide have diabetes mellitus . By the year 2030, it is predicted that diabetes will become the seventh leading cause of death in the world. Development of chronic kidney disease (CKD) in patients with diabetes adds significantly to the morbidity and mortality and significantly increases health care costs, even before the development of end stage renal disease (ESRD). Evidence  acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Diabetic nephropathy (DN) is increasing rapidly worldwide. It is the leading cause of new cases of ESRD in the USA.  Interestingly, although DN is the most common cause of ESRD in diabetic patients, diabetes mellitus is also an independent and strong risk factor for ESRD ascribed to causes other than DN (e.g. hypertensive nephropathy). It is important to be aware of the pitfalls of using the urine albumin level in predicting development and progression of diabetic nephropathy in order to treat and advise the patients accurately.  Research into finding new markers is rapidly evolving but current progress makes it likely we will be using the urine albumin level for some years into the future.

Evaluation of Proteus as a Tool for the Rapid Development of Models of Hydrologic Systems

NASA Astrophysics Data System (ADS)

Weigand, T. M.; Farthing, M. W.; Kees, C. E.; Miller, C. T.

2013-12-01

Models of modern hydrologic systems can be complex and involve a variety of operators with varying character. The goal is to implement approximations of such models that are both efficient for the developer and computationally efficient, which is a set of naturally competing objectives. Proteus is a Python-based toolbox that supports prototyping of model formulations as well as a wide variety of modern numerical methods and parallel computing. We used Proteus to develop numerical approximations for three models: Richards' equation, a brine flow model derived using the Thermodynamically Constrained Averaging Theory (TCAT), and a multiphase TCAT-based tumor growth model. For Richards' equation, we investigated discontinuous Galerkin solutions with higher order time integration based on the backward difference formulas. The TCAT brine flow model was implemented using Proteus and a variety of numerical methods were compared to hand coded solutions. Finally, an existing tumor growth model was implemented in Proteus to introduce more advanced numerics and allow the code to be run in parallel. From these three example models, Proteus was found to be an attractive open-source option for rapidly developing high quality code for solving existing and evolving computational science models.

Fundamentals of precision medicine

PubMed Central

Divaris, Kimon

2018-01-01

Imagine a world where clinicians make accurate diagnoses and provide targeted therapies to their patients according to well-defined, biologically-informed disease subtypes, accounting for individual differences in genetic make-up, behaviors, cultures, lifestyles and the environment. This is not as utopic as it may seem. Relatively recent advances in science and technology have led to an explosion of new information on what underlies health and what constitutes disease. These novel insights emanate from studies of the human genome and microbiome, their associated transcriptomes, proteomes and metabolomes, as well as epigenomics and exposomics—such ‘omics data can now be generated at unprecedented depth and scale, and at rapidly decreasing cost. Making sense and integrating these fundamental information domains to transform health care and improve health remains a challenge—an ambitious, laudable and high-yield goal. Precision dentistry is no longer a distant vision; it is becoming part of the rapidly evolving present. Insights from studies of the human genome and microbiome, their associated transcriptomes, proteomes and metabolomes, and epigenomics and exposomics have reached an unprecedented depth and scale. Much more needs to be done, however, for the realization of precision medicine in the oral health domain. PMID:29227115

Pyroshock: Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmerman, R.M.

1993-02-01

This paper represents a review copy for text that is to be included in the Shock and Vibration Recommended Practice Document. This section on pyroshock is written an a general introduction to and description of the topic loading to presentation of an extensive bibliography on the subject. Pyroshock is an evolving science that needs continued focus on both achieving improvements in testing and measurement techniques and advancing instrumentation capabilities. When desired in the near future, recommended practices can be presented. Pyroshock phenomena are associated with separation systems of missiles. spacecraft, and in some cases airplanes. During launch, a rocket drivenmore » vehicle may be exposed to 19 to 30 g`s of acceleration with predominant frequencies less than 200 Hz. After launch or takeoffs sections or parts of vehicles may be separated rapidly using explosive driven release mechanisms. Separations can involve stage disconnections for spacecraft sections or payload ejections from missiles and airplanes. At separation, localized pyrotechnic induced accelerations may range from 1000 to over 100,000 g`s at frequencies much higher than 1000 Hz. These pyroshocks are characterized by high intensity, high frequency transients that decay rapidly. Pyroshock impulses have insignificant velocity changes.« less

Issues in Renewable Energy Education

ERIC Educational Resources Information Center

Thomas, Chacko; Jennings, Philip; Lloyd, Bob

2008-01-01

Renewable energy education is evolving rapidly in response to drivers such as oil depletion and global warming. There is a rapidly increasing level of student interest in these topics and a growing demand from industry and government for skilled personnel to develop sustainable energy systems and greenhouse solutions. Several Australian and New…

Effective Integration of the World-Wide Web in Earth Science Education.

ERIC Educational Resources Information Center

Herbert, Bruce; Bednarz, Sarah; Boyd, Tom; Blake, Sally; Harder, Vicki; Sutter, Marilyn

The earth sciences is an evolving set of disciplines encompassing more than 30 specialties; however, earth scientists continue to be trained within the traditional disciplinary structure. Earth science education should focus not only on student acquisition and retention of factual knowledge, but also on the development of higher-order skills…

Reconsidering Simulations in Science Education at a Distance: Features of Effective Use

ERIC Educational Resources Information Center

Blake, C.; Scanlon, E.

2007-01-01

This paper proposes a reconsideration of use of computer simulations in science education. We discuss three studies of the use of science simulations for undergraduate distance learning students. The first one, "The Driven Pendulum" simulation is a computer-based experiment on the behaviour of a pendulum. The second simulation, "Evolve" is…

Towards Understanding and Managing Sustainable Complex, Dynamic Environmental/Economic/Social Systems - The Evolving Role of the Natural Sciences

EPA Science Inventory

Historically the natural sciences have played a major role in informing environmental management decisions. However, review of landmark cases like Love Canal, NY and Times Beach, MO have shown that the value of natural science information in decision making can be overwhelmed by ...

Dynamic Framing in the Communication of Scientific Research: Texts and Interactions

ERIC Educational Resources Information Center

Davis, Pryce R.; Russ, Rosemary S.

2015-01-01

The fields of science education and science communication share the overarching goal of helping non-experts and non-members of the professional science community develop knowledge of the content and processes of scientific research. However, the specific audiences, methods, and aims employed in the two fields have evolved quite differently and as…

Bioinformatics: Current Practice and Future Challenges for Life Science Education

ERIC Educational Resources Information Center

Hack, Catherine; Kendall, Gary

2005-01-01

It is widely predicted that the application of high-throughput technologies to the quantification and identification of biological molecules will cause a paradigm shift in the life sciences. However, if the biosciences are to evolve from a predominantly descriptive discipline to an information science, practitioners will require enhanced skills in…

Planetary data system requirements: Multi-mission radio science requirements for the 1978 to 1988 era

NASA Technical Reports Server (NTRS)

Howard, H. T. (Editor)

1979-01-01

The functional and performance requirements for support of multimission radio science are established. The classes of radio science investigation are described and the needed data is discussed. This document is for a sliding ten year period and will be iterated as the mission set evolves.

Inquiry-Based Learning: A Framework for Assessing Science in the Early Years

ERIC Educational Resources Information Center

Marian, Hazel; Jackson, Claire

2017-01-01

This article draws on current literature leading to the development of a holistic framework to support practitioners in observation and assessment of childrens evolving inquiry skills. Evidence from the 2011 Trends in International Maths and Science Study (TIMSS) in England identifies a decline of year five student achievement in science. A…

Rapid adaptation to climate facilitates range expansion of an invasive plant.

PubMed

Colautti, Robert I; Barrett, Spencer C H

2013-10-18

Adaptation to climate, evolving over contemporary time scales, could facilitate rapid range expansion across environmental gradients. Here, we examine local adaptation along a climatic gradient in the North American invasive plant Lythrum salicaria. We show that the evolution of earlier flowering is adaptive at the northern invasion front where it increases fitness as much as, or more than, the effects of enemy release and the evolution of increased competitive ability. However, early flowering decreases investment in vegetative growth, which reduces fitness by a factor of 3 in southern environments where the North American invasion commenced. Our results demonstrate that local adaptation can evolve quickly during range expansion, overcoming environmental constraints on propagule production.

Central endoscopy reads in inflammatory bowel disease clinical trials: The role of the imaging core lab.

PubMed

Ahmad, Harris; Berzin, Tyler M; Yu, Hui Jing; Huang, Christopher S; Mishkin, Daniel S

2014-08-01

Clinical trials in inflammatory bowel disease (IBD) are evolving at a rapid pace by employing central reading for endoscopic mucosal assessment in a field that was, historically, largely based on assessments by local physicians. This transition from local to central reading carries with it numerous technical, operational, and scientific challenges, many of which can be resolved by imaging core laboratories (ICLs), a concept that has a longer history in clinical trials in a number of diseases outside the realm of gastroenterology. For IBD trials, ICLs have the dual goals of providing objective, consistent assessments of endoscopic findings using central-reading paradigms whilst providing important expertise with regard to operational issues and regulatory expectations. This review focuses on current approaches to using ICLs for central endoscopic reading in IBD trials. © The Author(s) 2014. Published by Oxford University Press and the Digestive Science Publishing Co. Limited.

Monitoring and evaluation of rowing performance using mobile mapping data

NASA Astrophysics Data System (ADS)

Mpimis, A.; Gikas, V.

2011-12-01

Traditionally, the term mobile mapping refers to a means of collecting geospatial data using mapping sensors that are mounted on a mobile platform. Historically, this process was mainly driven by the need for highway infrastructure mapping and transportation corridor inventories. However, the recent advances in mapping sensor and telecommunication technologies create the opportunity that, completely new, emergent application areas of mobile mapping to evolve rapidly. This article examines the potential of mobile mapping technology (MMT) in sports science and in particular in competitive rowing. Notably, in this study the concept definition of mobile mapping somehow differs from the traditional one in a way that, the end result is not relevant to the geospatial information acquired as the moving platform travels in space. In contrast, the interest is placed on the moving platform (rowing boat) itself and on the various subsystems which are also in continuous motion.

Consensus in the Management of Multiple Myeloma in India at Myeloma State of the Art 2016 Conference.

PubMed

Yanamandra, Uday; Khattry, Navin; Kumar, Shaji; Raje, Noopur; Jain, Arihant; Jagannath, Sundar; Menon, Hari; Kumar, Lalit; Varma, Neelam; Varma, Subhash; Saikia, Tapan; Malhotra, Pankaj

2017-03-01

The science of multiple myeloma (MM) and related plasma cell disorders is rapidly evolving with increased understanding of the disease biology and recent approval of the newer drugs widening the therapeutic armamentarium. Despite multiple international guidelines regarding the management of this disease, the practice of managing MM is not uniform amongst Indian physicians. There are challenges in management which are unique to the Indian patients. This review discusses these challenges and the consensus of the nation-wide experts in dealing with the same. We also briefly highlighted the perspective of international experts as discussed in the Myeloma State of the Art conference held in September 2016 at PGI, Chandigarh. An I ndian M yeloma A cademic G roup e (IMAGe) group was formed to strengthen the research, create awareness about myeloma and related disorders and form consensus guidelines/ recommendations that can be adapted to the Indian Scenario.

Communal Cooperation in Sensor Networks for Situation Management

NASA Technical Reports Server (NTRS)

Jones, Kennie H.; Lodding, Kenneth N.; Olariu, Stephan; Wilson, Larry; Xin,Chunsheng

2006-01-01

Situation management is a rapidly evolving science where managed sources are processed as realtime streams of events and fused in a way that maximizes comprehension, thus enabling better decisions for action. Sensor networks provide a new technology that promises ubiquitous input and action throughout an environment, which can substantially improve information available to the process. Here we describe a NASA program that requires improvements in sensor networks and situation management. We present an approach for massively deployed sensor networks that does not rely on centralized control but is founded in lessons learned from the way biological ecosystems are organized. In this approach, fully distributed data aggregation and integration can be performed in a scalable fashion where individual motes operate based on local information, making local decisions that achieve globally-meaningful results. This exemplifies the robust, fault-tolerant infrastructure required for successful situation management systems.

A decision framework for identifying models to estimate forest ecosystem services gains from restoration

USGS Publications Warehouse

Christin, Zachary; Bagstad, Kenneth J.; Verdone, Michael

2016-01-01

Restoring degraded forests and agricultural lands has become a global conservation priority. A growing number of tools can quantify ecosystem service tradeoffs associated with forest restoration. This evolving “tools landscape” presents a dilemma: more tools are available, but selecting appropriate tools has become more challenging. We present a Restoration Ecosystem Service Tool Selector (RESTS) framework that describes key characteristics of 13 ecosystem service assessment tools. Analysts enter information about their decision context, services to be analyzed, and desired outputs. Tools are filtered and presented based on five evaluative criteria: scalability, cost, time requirements, handling of uncertainty, and applicability to benefit-cost analysis. RESTS uses a spreadsheet interface but a web-based interface is planned. Given the rapid evolution of ecosystem services science, RESTS provides an adaptable framework to guide forest restoration decision makers toward tools that can help quantify ecosystem services in support of restoration.

Controversial endocrine interventions for the aged.

PubMed

Leow, M K S; Loh, K C

2006-07-01

Specific endocrine changes occur with the ageing process. The last decade has witnessed significant progress in the basic and clinical science of ageing, thereby rejuvenating the interest in anti-ageing medicine, especially that of hormone replacement, by medical professionals and the lay public. However, endocrine manipulation as a therapeutic strategy for ageing is still evolving as continuing research attempts to answer the many questions of what it can achieve at the risk of incurring unknown long-term adverse effects. The current day doctor is confronted with a host of options, and will benefit from a synopsis of the latest evidence before making the most appropriate decision for aged patients seeking hormonal replacement therapy as a means to counter the effects of ageing. This review aims to give a rapid overview of the endocrine profile of geriatric population and the studies on the more controversial hormonal replacement therapies for the aged.

Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association.

PubMed

Hall, Jennifer L; Ryan, John J; Bray, Bruce E; Brown, Candice; Lanfear, David; Newby, L Kristin; Relling, Mary V; Risch, Neil J; Roden, Dan M; Shaw, Stanley Y; Tcheng, James E; Tenenbaum, Jessica; Wang, Thomas N; Weintraub, William S

2016-04-01

The process of scientific discovery is rapidly evolving. The funding climate has influenced a favorable shift in scientific discovery toward the use of existing resources such as the electronic health record. The electronic health record enables long-term outlooks on human health and disease, in conjunction with multidimensional phenotypes that include laboratory data, images, vital signs, and other clinical information. Initial work has confirmed the utility of the electronic health record for understanding mechanisms and patterns of variability in disease susceptibility, disease evolution, and drug responses. The addition of biobanks and genomic data to the information contained in the electronic health record has been demonstrated. The purpose of this statement is to discuss the current challenges in and the potential for merging electronic health record data and genomics for cardiovascular research. © 2016 American Heart Association, Inc.

Identifying Marine Phytoplankton

NASA Astrophysics Data System (ADS)

Hargraves, Paul E.

Until recently, anyone who needed to accurately identify marine phytoplankton had one of four choices: use the outdated Englishlanguage volumes by E. E. Cupp and N. I. Hendey plus the more recent book by J. Dodge, acquire a working knowledge of German and use the old volumes by Schiller and Hustedt, spend huge amounts of time in an exceedingly well-equipped marine science library trying in vain to keep up with the rapidly evolving field of phytoplankton systematics and taxonomy, or track down one of the rarest of endangered species—a phytoplankton taxonomist—and beg for help.To these unfortunate choices is added one considerably more hopeful: Identifying Marine Phytoplankton. This volume, which has seven contributing authors, contains most of the taxonomic groups that make up the planktonic autotrophs and some heterotrophs of the seas, coasts, and estuaries of the world (missing are cyanobacteria and some of the picoplankton groups).

NASA's EOSDIS Near Term Challenges

NASA Technical Reports Server (NTRS)

Behnke, Jeanne

2018-01-01

Given the long-term requirements, and the rapid pace of information technology and changing expectations of the user community, the ESDIS Project has had to evolve EOSDIS continually over the past three decades. However, many challenges remain. One near-term challenge is the enormous quantity of new data that will need to be managed by the EOSDIS. With the upcoming launch of the latest NASA missions coupled with existing operational missions and field campaigns, EOSDIS can expect to handle as much as 50 petabytes of data per year. In perspective, this is twice the size of the current existing archive, which took over 21 years to collect. Another continuing challenge is the disparate requirements of a diverse science community. Maintaining rigorous long-term data preservation, supporting ease of discovery and access, incorporating user feedback, enabling reanalysis/ reprocessing, and agile integration of new data sources, continue to be the Project's objectives.

Computer-Aided Screening of Conjugated Polymers for Organic Solar Cell: Classification by Random Forest.

PubMed

Nagasawa, Shinji; Al-Naamani, Eman; Saeki, Akinori

2018-05-17

Owing to the diverse chemical structures, organic photovoltaic (OPV) applications with a bulk heterojunction framework have greatly evolved over the last two decades, which has produced numerous organic semiconductors exhibiting improved power conversion efficiencies (PCEs). Despite the recent fast progress in materials informatics and data science, data-driven molecular design of OPV materials remains challenging. We report a screening of conjugated molecules for polymer-fullerene OPV applications by supervised learning methods (artificial neural network (ANN) and random forest (RF)). Approximately 1000 experimental parameters including PCE, molecular weight, and electronic properties are manually collected from the literature and subjected to machine learning with digitized chemical structures. Contrary to the low correlation coefficient in ANN, RF yields an acceptable accuracy, which is twice that of random classification. We demonstrate the application of RF screening for the design, synthesis, and characterization of a conjugated polymer, which facilitates a rapid development of optoelectronic materials.

[Impact of digital technology on clinical practices: perspectives from surgery].

PubMed

Zhang, Y; Liu, X J

2016-04-09

Digital medical technologies or computer aided medical procedures, refer to imaging, 3D reconstruction, virtual design, 3D printing, navigation guided surgery and robotic assisted surgery techniques. These techniques are integrated into conventional surgical procedures to create new clinical protocols that are known as "digital surgical techniques". Conventional health care is characterized by subjective experiences, while digital medical technologies bring quantifiable information, transferable data, repeatable methods and predictable outcomes into clinical practices. Being integrated into clinical practice, digital techniques facilitate surgical care by improving outcomes and reducing risks. Digital techniques are becoming increasingly popular in trauma surgery, orthopedics, neurosurgery, plastic and reconstructive surgery, imaging and anatomic sciences. Robotic assisted surgery is also evolving and being applied in general surgery, cardiovascular surgery and orthopedic surgery. Rapid development of digital medical technologies is changing healthcare and clinical practices. It is therefore important for all clinicians to purposefully adapt to these technologies and improve their clinical outcomes.

Body of Knowledge of Family and Consumer Sciences.

ERIC Educational Resources Information Center

Baugher, Shirley L.; Anderson, Carol L.; Green, Kinsey B.; Nickols, Sharon Y.; Shane, Jan; Jolly, Laura; Miles, Joyce

2000-01-01

Describes how the body of knowledge for family and consumer sciences has evolved over the years; outlines external influences and trends affecting the field. Presents a dialogue of elected leaders discussing the body of knowledge for the future. (JOW)

Social Media Strategies for the United States Armed Forces: An Israeli Case Study

DTIC Science & Technology

2013-05-03

experiences a significant military failure. Discussion: The US military is facing pressure to adapt to a rapidly evolving information environment...Marine Corps, but as I explored the issue, it rapidly became apparent that the institutional structures that both enable and constrain social media use... rapidly changing nature of the information environment itself is causing drastic societal changes, with widespread effects on both individual and

Let the social sciences evolve.

PubMed

Smaldino, Paul E; Waring, Timothy M

2014-08-01

We agree that evolutionary perspectives may help us organize many divergent realms of the science of human behavior. Nevertheless, an imperative to unite all social science under an evolutionary framework risks turning off researchers who have their own theoretical perspectives that can be informed by evolutionary theory without being exclusively defined by it. We propose a few considerations for scholars interested in joining the evolutionary and social sciences.

From the NSF: The National Science Foundation's Investments in Broadening Participation in Science, Technology, Engineering, and Mathematics Education through Research and Capacity Building

ERIC Educational Resources Information Center

James, Sylvia M.; Singer, Susan R.

2016-01-01

The National Science Foundation (NSF) has a long history of investment in broadening participation (BP) in science, technology, engineering, and mathematics (STEM) education. A review of past NSF BP efforts provides insights into how the portfolio of programs and activities has evolved and the broad array of innovative strategies that has been…

Symposium on Current Research in the Chemical Sciences: Third Annual Southern Station Chemical Sciences Meeting

Treesearch

Timothy G. Rials; [Editor

1994-01-01

The original charter for this annual meeting of chemical sciences personnel called for an informal atmosphere for the discussion of common concerns and needs. The years have seen the definition of our "common concern" evolve into a sharing of our efforts in applying the science of chemistry to the resolution of problems faced by our forest resource. I believe...

Experimental evolution of an alternating uni- and multicellular life cycle in Chlamydomonas reinhardtii

PubMed Central

Ratcliff, William C.; Herron, Matthew D.; Howell, Kathryn; Pentz, Jennifer T.; Rosenzweig, Frank; Travisano, Michael

2013-01-01

The transition to multicellularity enabled the evolution of large, complex organisms, but early steps in this transition remain poorly understood. Here we show that multicellular complexity, including development from a single cell, can evolve rapidly in a unicellular organism that has never had a multicellular ancestor. We subject the alga Chlamydomonas reinhardtii to conditions that favour multicellularity, resulting in the evolution of a multicellular life cycle in which clusters reproduce via motile unicellular propagules. While a single-cell genetic bottleneck during ontogeny is widely regarded as an adaptation to limit among-cell conflict, its appearance very early in this transition suggests that it did not evolve for this purpose. Instead, we find that unicellular propagules are adaptive even in the absence of intercellular conflict, maximizing cluster-level fecundity. These results demonstrate that the unicellular bottleneck, a trait essential for evolving multicellular complexity, can arise rapidly via co-option of the ancestral unicellular form. PMID:24193369

Translating Alcohol Research

PubMed Central

Batman, Angela M.; Miles, Michael F.

2015-01-01

Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of streamlining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD. PMID:26259085

Translating Alcohol Research: Opportunities and Challenges.

PubMed

Batman, Angela M; Miles, Michael F

2015-01-01

Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of stream-lining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD.

Pharmacy Education and Practice in 13 Middle Eastern Countries

PubMed Central

Kheir, Nadir; Zaidan, Manal; Younes, Husam; El Hajj, Maguy; Wilbur, Kerry

2008-01-01

The Arab world has influenced the art and science of pharmacy for centuries. Pharmacy education and practice is continuing to evolve in the Arabic-speaking traditional Middle East countries, although relatively little information has been published in the English press. Our goal was to provide a high-level synopsis of conditions in this region. We selected 13 countries for review. Information was obtained by reviewing the available published literature and individual university and program web sites, as well as contacting program or country representatives. Seventy-eight active pharmacy schools in 12 countries were identified. At least 14,000 students (over 75% from Egypt) are admitted into baccalaureate degree programs every year. The 5-year baccalaureate degree remains the first professional degree to practice. While changes in pharmacy education have been relatively rapid over the past decade, the advancement of pharmacy practice, particularly in the private sector, appears to be slower. Hospital pharmacists often possess an advanced degree and tend to have a higher level of practice compared to that of community pharmacists. Despite the adversities that face academics and practitioners alike, there is a strong desire to advance the science and practice of pharmacy in the Middle East. PMID:19325953

A Working Framework for Enabling International Science Data System Interoperability

NASA Astrophysics Data System (ADS)

Hughes, J. Steven; Hardman, Sean; Crichton, Daniel J.; Martinez, Santa; Law, Emily; Gordon, Mitchell K.

2016-07-01

For diverse scientific disciplines to interoperate they must be able to exchange information based on a shared understanding. To capture this shared understanding, we have developed a knowledge representation framework that leverages ISO level reference models for metadata registries and digital archives. This framework provides multi-level governance, evolves independent of the implementation technologies, and promotes agile development, namely adaptive planning, evolutionary development, early delivery, continuous improvement, and rapid and flexible response to change. The knowledge representation is captured in an ontology through a process of knowledge acquisition. Discipline experts in the role of stewards at the common, discipline, and project levels work to design and populate the ontology model. The result is a formal and consistent knowledge base that provides requirements for data representation, integrity, provenance, context, identification, and relationship. The contents of the knowledge base are translated and written to files in suitable formats to configure system software and services, provide user documentation, validate input, and support data analytics. This presentation will provide an overview of the framework, present a use case that has been adopted by an entire science discipline at the international level, and share some important lessons learned.

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions.

PubMed

Marshall, Clement D; Hu, Michael S; Leavitt, Tripp; Barnes, Leandra A; Lorenz, H Peter; Longaker, Michael T

2018-02-01

Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar.

Delineating slowly and rapidly evolving fractions of the Drosophila genome.

PubMed

Keith, Jonathan M; Adams, Peter; Stephen, Stuart; Mattick, John S

2008-05-01

Evolutionary conservation is an important indicator of function and a major component of bioinformatic methods to identify non-protein-coding genes. We present a new Bayesian method for segmenting pairwise alignments of eukaryotic genomes while simultaneously classifying segments into slowly and rapidly evolving fractions. We also describe an information criterion similar to the Akaike Information Criterion (AIC) for determining the number of classes. Working with pairwise alignments enables detection of differences in conservation patterns among closely related species. We analyzed three whole-genome and three partial-genome pairwise alignments among eight Drosophila species. Three distinct classes of conservation level were detected. Sequences comprising the most slowly evolving component were consistent across a range of species pairs, and constituted approximately 62-66% of the D. melanogaster genome. Almost all (>90%) of the aligned protein-coding sequence is in this fraction, suggesting much of it (comprising the majority of the Drosophila genome, including approximately 56% of non-protein-coding sequences) is functional. The size and content of the most rapidly evolving component was species dependent, and varied from 1.6% to 4.8%. This fraction is also enriched for protein-coding sequence (while containing significant amounts of non-protein-coding sequence), suggesting it is under positive selection. We also classified segments according to conservation and GC content simultaneously. This analysis identified numerous sub-classes of those identified on the basis of conservation alone, but was nevertheless consistent with that classification. Software, data, and results available at www.maths.qut.edu.au/-keithj/. Genomic segments comprising the conservation classes available in BED format.

Cloning of novel rice blast resistance genes from two rapidly evolving NBS-LRR gene families in rice.

PubMed

Guo, Changjiang; Sun, Xiaoguang; Chen, Xiao; Yang, Sihai; Li, Jing; Wang, Long; Zhang, Xiaohui

2016-01-01

Most rice blast resistance genes (R-genes) encode proteins with nucleotide-binding site (NBS) and leucine-rich repeat (LRR) domains. Our previous study has shown that more rice blast R-genes can be cloned in rapidly evolving NBS-LRR gene families. In the present study, two rapidly evolving R-gene families in rice were selected for cloning a subset of genes from their paralogs in three resistant rice lines. A total of eight functional blast R-genes were identified among nine NBS-LRR genes, and some of these showed resistance to three or more blast strains. Evolutionary analysis indicated that high nucleotide diversity of coding regions served as important parameters in the determination of gene resistance. We also observed that amino-acid variants (nonsynonymous mutations, insertions, or deletions) in essential motifs of the NBS domain contribute to the blast resistance capacity of NBS-LRR genes. These results suggested that the NBS regions might also play an important role in resistance specificity determination. On the other hand, different splicing patterns of introns were commonly observed in R-genes. The results of the present study contribute to improving the effectiveness of R-gene identification by using evolutionary analysis method and acquisition of novel blast resistance genes.

New Interfacial Nanochemistry on Sensory Bioscaffold-Membranes of Nanobelts

NASA Astrophysics Data System (ADS)

Chen, Feng

Nanostructured bioscaffolds and biosensors are evolving as popular and powerful tools in life science and biotechnology, due to the possible control of their surface and structural properties at the nm-scale. Being seldom discussed in literature and long-underexploited in materials and biomedical sciences, development of nanofiber-based sensory bioscaffolds has great promises and grand challenges in finding an ideal platform for low-cost quantifications of biological and chemical species in real-time, label-free, and ultrasensitive fashion. In this study, titanate nanobelts were first of all synthesized, from hydrothermal reactions of a NaOH (or KOH solution) with TiO2 powder, to possess underexploited structure and surface vital to the rapid and label-free electrochemical detections of protein (cytochrome c) and neurotransmitter (dopamine). This work is based on a suite of new physical and chemical properties on the titanate nanobelt in water, including high surface area, zwitterionic surface, chemical- and photochemical-durability, cation-exchange and anion- and cation-sorption capacities, protein- and cell-compatibility, thermal-stability, and charge conductivity. The Fourier transform infrared (FTIR) was used for identifying any denaturing of the cytochrome c pre-immobilized on the titanate nanobelts. On that basis, the pheochromocytoma cells (PC-12 cell) were chosen to grow on the titanate nanobelts. These experiments prove that the sensory bioscaffolds of titanate nanobelt-membrane is a multiplex platform for developing new tools for energy, environmental and life sciences.

One Health in social networks and social media

PubMed Central

Mekaru, S.R.; Brownstein, J.S.

2015-01-01

Summary In the rapidly evolving world of social media, social networks, mobile applications and citizen science, online communities can develop organically and separately from larger or more established organisations. The One Health online community is experiencing expansion from both the bottom up and the top down. In this paper, the authors review social media’s strengths and weaknesses, earlier work examining Internet resources for One Health, the current state of One Health in social media (e.g. Facebook, Twitter, YouTube) and online social networking sites (e.g. LinkedIn and ResearchGate), as well as social media in One Health-related citizen science projects. While One Health has a fairly strong presence on websites, its social media presence is more limited and has an uneven geographic distribution. In work following the Stone Mountain Meeting, the One Health Global Network Task Force Report recommended the creation of an online community of practice. Professional social networks as well as the strategic use of social media should be employed in this effort. Finally, One Health-related research projects using volunteers (citizen science) often use social media to enhance their recruitment. Including these researchers in a community of practitioners would take full advantage of their existing social media presence. In conclusion, the interactive nature of social media, combined with increasing global Internet access, provides the One Health community with opportunities to meaningfully expand their community and promote their message. PMID:25707189

One Health in social networks and social media.

PubMed

Mekaru, S R; Brownstein, J S

2014-08-01

In the rapidly evolving world of social media, social networks, mobile applications and citizen science, online communities can develop organically and separately from larger or more established organisations. The One Health online community is experiencing expansion from both the bottom up and the top down. In this paper, the authors review social media's strengths and weaknesses, earlier work examining Internet resources for One Health, the current state of One Health in social media (e.g. Facebook, Twitter, YouTube) and online social networking sites (e.g. LinkedIn and ResearchGate), as well as social media in One Health-related citizen science projects. While One Health has a fairly strong presence on websites, its social media presence is more limited and has an uneven geographic distribution. In work following the Stone Mountain Meeting,the One Health Global Network Task Force Report recommended the creation of an online community of practice. Professional social networks as well as the strategic use of social media should be employed in this effort. Finally, One Health-related research projects using volunteers (citizen science) often use social media to enhance their recruitment. Including these researchers in a community of practitioners would take full advantage of their existing social media presence. In conclusion, the interactive nature of social media, combined with increasing global Internet access, provides the One Health community with opportunities to meaningfully expand their community and promote their message.

Linkage of reproductive sciences: from 'quick fix' to 'integrated' conservation.

PubMed

Wildt, D E; Ellis, S; Howard, J G

2001-01-01

Our laboratory has experienced four phases in understanding how the reproductive sciences contribute to genuine conservation of biodiversity. The first is the 'quick fix phase' in which the erroneous assumption is made that extant knowledge and techniques are readily adaptable to an unstudied wild animal to produce offspring rapidly. The second is the 'species-specificity phase' in which it is recognized that every species has evolved unique reproductive mechanisms that must be mastered before propagation can be enhanced. The third is the 'applicability phase' in which one grasps that all the new knowledge and technology are of minimal relevance without the cooperation of wildlife managers. The final phase is 'integration', the realization that reproduction is only one component in an abundantly complex conservation puzzle that requires interweaving many scientific disciplines with elaborate biopolitical, economic and habitat variables. These phases are illustrated using 20 years of experience with wildlife species, including the cheetah, black-footed ferret and giant panda. We conclude that the foremost value of the reproductive sciences for conserving endangered species is the discipline's powerful laboratory tools for understanding species-specific reproductive mechanisms. Such scholarly information, when applied holistically, can be used to improve management by natural or, occasionally, assisted breeding. Genuine conservation is achieved only when the reproductive knowledge and technologies are integrated into multidisciplinary programmes that preserve species integrity ex situ and preferably in situ.

Cost-effectiveness of natalizumab vs fingolimod for the treatment of relapsing-remitting multiple sclerosis: analyses in Sweden.

PubMed

O'Day, Ken; Meyer, Kellie; Stafkey-Mailey, Dana; Watson, Crystal

2015-04-01

To assess the cost-effectiveness of natalizumab vs fingolimod over 2 years in relapsing-remitting multiple sclerosis (RRMS) patients and patients with rapidly evolving severe disease in Sweden. A decision analytic model was developed to estimate the incremental cost per relapse avoided of natalizumab and fingolimod from the perspective of the Swedish healthcare system. Modeled 2-year costs in Swedish kronor of treating RRMS patients included drug acquisition costs, administration and monitoring costs, and costs of treating MS relapses. Effectiveness was measured in terms of MS relapses avoided using data from the AFFIRM and FREEDOMS trials for all patients with RRMS and from post-hoc sub-group analyses for patients with rapidly evolving severe disease. Probabilistic sensitivity analyses were conducted to assess uncertainty. The analysis showed that, in all patients with MS, treatment with fingolimod costs less (440,463 Kr vs 444,324 Kr), but treatment with natalizumab results in more relapses avoided (0.74 vs 0.59), resulting in an incremental cost-effectiveness ratio (ICER) of 25,448 Kr per relapse avoided. In patients with rapidly evolving severe disease, natalizumab dominated fingolimod. Results of the sensitivity analysis demonstrate the robustness of the model results. At a willingness-to-pay (WTP) threshold of 500,000 Kr per relapse avoided, natalizumab is cost-effective in >80% of simulations in both patient populations. Limitations include absence of data from direct head-to-head studies comparing natalizumab and fingolimod, use of relapse rate reduction rather than sustained disability progression as the primary model outcome, assumption of 100% adherence to MS treatment, and exclusion of adverse event costs in the model. Natalizumab remains a cost-effective treatment option for patients with MS in Sweden. In the RRMS patient population, the incremental cost per relapse avoided is well below a 500,000 Kr WTP threshold per relapse avoided. In the rapidly evolving severe disease patient population, natalizumab dominates fingolimod.

A critical analysis of methods for rapid and nondestructive determination of wood density in standing trees

Treesearch

Shan Gao; Xiping Wang; Michael C. Wiemann; Brian K. Brashaw; Robert J. Ross; Lihai Wang

2017-01-01

Key message Field methods for rapid determination of wood density in trees have evolved from increment borer, torsiometer, Pilodyn, and nail withdrawal into sophisticated electronic tools of resistance drilling measurement. A partial resistance drilling approach coupled with knowledge of internal tree density distribution may...

Searching for a "Pedagogy of Hope": Teacher Education and the Social Sciences

ERIC Educational Resources Information Center

Samuel, Michael

2010-01-01

I analyse module outlines within a particular school of social sciences located in a faculty of education, and uncover the evolving systems of teaching social sciences in a teacher education curriculum. The data are analysed through two theoretical lenses: firstly, through the lense of models of teacher education and professional development, and…

Repositioning Science Reform Efforts: Four Practical Recommendations from the Field

ERIC Educational Resources Information Center

Ness, Daniel; Farenga, Stephen J.; Shah, Vishal; Garofalo, Salvatore G.

2016-01-01

Appeals to reform science education by policy makers are not new phenomena. To be sure, while science reform efforts have been ongoing occurrences for nearly six decades, perpetual educational reform efforts as a whole have been evolving and gaining momentum in number for more than a century. The general motivation for continual reform appears to…

Convergent Evolution in the Interest of Integrative Problem Solving: Connecting the Policy Sciences and Interdisciplinary Studies

ERIC Educational Resources Information Center

Wallace, Richard L.; Clark, Susan G.

2014-01-01

The contemporary fields of interdisciplinary studies and the policy sciences have evolved over similar intellectual paths and timelines, beginning in the early 20th century. Both have their roots in professional efforts--within and outside the academy--to address numerous, growing, and complex problems that face humanity. The policy sciences'…

Science and the Entrepreneurial University. Research & Occasional Paper Series: CSHE.9.10

ERIC Educational Resources Information Center

Atkinson, Richard C.; Pelfrey, Patricia A.

2010-01-01

The current and still-evolving role of the American research university has been shaped by four key developments in the past sixty-five years: the historic decision to establish a comprehensive postwar federal science policy, described in Vannevar Bush's 1945 report, "Science, The Endless Frontier;" the Bayh-Dole Act of 1980; economic analyses…

A Summary of the February 2010 Forum on the Future of Nursing: Education

ERIC Educational Resources Information Center

National Academies Press, 2010

2010-01-01

As the U.S. health care system continues to evolve, the role of nurses also needs to evolve. Nurses must strike a delicate balance among advancing science, translating and applying research, and caring for individuals and families across all settings. Preparing nurses to achieve this balance is a significant challenge. The education system should…

A Season of Change: How Science Librarians Can Remain Relevant with Open Access and Scholarly Communications Initiatives

ERIC Educational Resources Information Center

Brown, Elizabeth

2009-01-01

The current rate of change suggests scholarly communications issues such as new publication models and technology to connect library and research tools is expected to continue into the foreseeable future. As models evolve, standards develop, and scientists evolve in their communication patterns, librarians will need to embrace transitional…

Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit

ERIC Educational Resources Information Center

Olson, Steve; Labov, Jay B.

2012-01-01

The National Research Council (NRC) and National Academy of Engineering (NAE) have released a new report, "Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit." Based on a national summit that was supported by the National Science Foundation and organized by the NRC and the NAE, the report highlights the importance of…

Get Involved in Planetary Discoveries through New Worlds, New Discoveries

NASA Astrophysics Data System (ADS)

Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA

2013-01-01

"New Worlds, New Discoveries" is a synthesis of NASA’s 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun’s family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site’s event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to share the exciting planetary science discoveries as they’re uncovered during this unprecedented period of solar system exploration!

Nanotoxicology and nanomedicine: making development decisions in an evolving governance environment

NASA Astrophysics Data System (ADS)

Rycroft, Taylor; Trump, Benjamin; Poinsatte-Jones, Kelsey; Linkov, Igor

2018-02-01

The fields of nanomedicine, risk analysis, and decision science have evolved considerably in the past decade, providing developers of nano-enabled therapies and diagnostic tools with more complete information than ever before and shifting a fundamental requisite of the nanomedical community from the need for more information about nanomaterials to the need for a streamlined method of integrating the abundance of nano-specific information into higher-certainty product design decisions. The crucial question facing nanomedicine developers that must select the optimal nanotechnology in a given situation has shifted from "how do we estimate nanomaterial risk in the absence of good risk data?" to "how can we derive a holistic characterization of the risks and benefits that a given nanomaterial may pose within a specific nanomedical application?" Many decision support frameworks have been proposed to assist with this inquiry; however, those based in multicriteria decision analysis have proven to be most adaptive in the rapidly evolving field of nanomedicine—from the early stages of the field when conditions of significant uncertainty and incomplete information dominated, to today when nanotoxicology and nano-environmental health and safety information is abundant but foundational paradigms such as chemical risk assessment, risk governance, life cycle assessment, safety-by-design, and stakeholder engagement are undergoing substantial reformation in an effort to address the needs of emerging technologies. In this paper, we reflect upon 10 years of developments in nanomedical engineering and demonstrate how the rich knowledgebase of nano-focused toxicological and risk assessment information developed over the last decade enhances the capability of multicriteria decision analysis approaches and underscores the need to continue the transition from traditional risk assessment towards risk-based decision-making and alternatives-based governance for emerging technologies.

Rapid evolution of analog circuits configured on a field programmable transistor array

NASA Technical Reports Server (NTRS)

Stoica, A.; Ferguson, M. I.; Zebulum, R. S.; Keymeulen, D.; Duong, V.; Daud, T.

2002-01-01

The purpose of this paper is to illustrate evolution of analog circuits on a stand-alone board-level evolvable system (SABLES). SABLES is part of an effort to achieve integrated evolvable systems. SABLES provides autonomous, fast (tens to hundreds of seconds), on-chip circuit evolution involving about 100,000 circuit evaluations. Its main components are a JPL Field Programmable Transistor Array (FPTA) chip used as transistor-level reconfigurable hardware, and a TI DSP that implements the evolutionary algorithm controlling the FPTA reconfiguration. The paper details an example of evolution on SABLES and points out to certain transient and memory effects that affect the stability of solutions obtained reusing the same piece of hardware for rapid testing of individuals during evolution.

CosmoQuest: Building community around Citizen Science Collaboration

NASA Astrophysics Data System (ADS)

Gay, P.

2015-12-01

CosmoQuest was envisioned in 2011 with a singular goal: to create a place where people of all backgrounds can learn and do science in a virtual research community. Like a brick-and-mortar center, CosmoQuest includes facilities for doing science and for educating its members through classes, seminars, and other forms of professional development. CosmoQuest is unique with its combination of public engagement in doing science—known as "citizen science"— and its diversity of learning opportunities that enable STEM education. Our suite of activities is able maximize people's ability to learn and do science, while improving scientific literacy. Since its launch on January 1, 2012, CosmoQuest has grown to become the most trafficked astronomy citizen science site on the English-language internet. It has hosted five citizen science portals supporting NASA SMD science and is the only citizen science site to have produced peer-reviewed surface science results [Robbins, et al. 2014]. CosmoQuest, however, is more than just citizen science. It is a virtual research center for the public, and for the educators who teach in classrooms and science centers. Like with with any research center, CosmoQuest's success hinges on its ability to build a committed research community, and the challenge has been creating this community without the benefit of real-world interactions. In this talk, we overview how CosmoQuest has built a virtual community through screen-to-screen interactions using a suite of technologies that must constantly evolve as the internet evolves.

The evolving role of data scientist during 20 years of the British Atmospheric Data Centre (Invited)

NASA Astrophysics Data System (ADS)

Pascoe, S.; Parton, G.; Pascoe, C.; Guillory, A.; da Costa, E. D.

2013-12-01

In 2014 The British Atmospheric Data Centre (BADC), now part of the Centre of Environmental Data Archival (CEDA), will celebrate its 20th anniversary. During its lifetime, most BADC staff have defined themselves as data scientists by virtue of being scientists by background and "data workers" by practice. However, the definition of data scientist has been ill defined until recently. As the term has become popularised in the world of business and general information technology, we ask ourselves to what extent the popular definition fits our profession. We observe that data science, as practised at CEDA, encompasses several roles which overlap and compliment each other as we strive to be enablers of data exploitation. For us a data scientist's skills include elements of data curation, software engineering, data infrastructure management and data-intensive research. As data science has evolved the balance between these roles has shifted in response to changes in technology, demands of the research community and funding drivers. We have had to balance our role as enablers of data exploitation, by providing services and infrastructure to the geo-science community, with our role as pioneers of data exploitation itself. By telling the story of how these roles have evolved during the 20 year history of the BADC, we aim to explore the maturing role of data scientist as practised within the geo-sciences and contrast that role with its recently popularised usage. Looking forward we will address questions about how centres of expertise, such as CEDA, can best increase the data capabilities of geo-science research as a whole in order to facilitate the transition to data-intensive science.

Adaptive Acquisition: An Evolving Framework for Tailoring Engineering and Procurement of Defense Systems

DTIC Science & Technology

2017-01-31

mapping critical business workflows and then optimizing them with appropriate evolutionary technology choices is often called “ Product Line Architecture... technologies , products , services, and processes, and the USG evaluates them against its 360o requirements objectives, and refines them as appropriate, clarity...in rapidly evolving technological domains (e.g. by applying best commercial practices for open standard product line architecture.) An MP might be

Innovations in scholarly publishing. Evolving trends in research communication in a digital age: examples from the BMJ.

PubMed

Jain, Anita

2014-01-01

As technology and communication evolve rapidly in this digital age, scholarly publishing is also undergoing a makeover to match the diverse needs of researchers and clinicians. The BMJ has been at the forefront of innovating the presentation of research to increase its readabillty and usefulness. This article presents some of recent formats used for research communication at the BMJ.

Enabling Communication and Navigation Technologies for Future Near Earth Science Missions

NASA Technical Reports Server (NTRS)

Israel, David J.; Heckler, Gregory; Menrad, Robert; Hudiburg, John; Boroson, Don; Robinson, Bryan; Cornwell, Donald

2016-01-01

In 2015, the Earth Regimes Network Evolution Study (ERNESt) proposed an architectural concept and technologies that evolve to enable space science and exploration missions out to the 2040 timeframe. The architectural concept evolves the current instantiations of the Near Earth Network and Space Network with new technologies to provide a global communication and navigation network that provides communication and navigation services to a wide range of space users in the near Earth domain. The technologies included High Rate Optical Communications, Optical Multiple Access (OMA), Delay Tolerant Networking (DTN), User Initiated Services (UIS), and advanced Position, Navigation, and Timing technology. This paper describes the key technologies and their current technology readiness levels. Examples of science missions that could be enabled by the technologies and the projected operational benefits of the architecture concept to missions are also described.

Surgical data science: The new knowledge domain

PubMed Central

Vedula, S. Swaroop; Hager, Gregory D.

2017-01-01

Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care. We foresee the emergence of Surgical/Interventional Data Science (SDS) as a key element to addressing these limitations and creating a sustainable path toward evidence-based improvement of interventional healthcare pathways. SDS will create tools to measure, model and quantify the pathways or processes within the context of patient health states or outcomes, and use information gained to inform healthcare decisions, guidelines, best practices, policy, and training, thereby improving the safety and quality of healthcare and its value. Data is pervasive throughout the surgical care pathway; thus, SDS can impact various aspects of care including prevention, diagnosis, intervention, or post-operative recovery. Existing literature already provides preliminary results suggesting how a data science approach to surgical decision-making could more accurately predict severe complications using complex data from pre-, intra-, and post-operative contexts, how it could support intra-operative decision-making using both existing knowledge and continuous data streams throughout the surgical care pathway, and how it could enable effective collaboration between human care providers and intelligent technologies. In addition, SDS is poised to play a central role in surgical education, for example, through objective assessments, automated virtual coaching, and robot-assisted active learning of surgical skill. However, the potential for transforming surgical care and training through SDS may only be realized through a cultural shift that not only institutionalizes technology to seamlessly capture data but also assimilates individuals with expertise in data science into clinical research teams. Furthermore, collaboration with industry partners from the inception of the discovery process promotes optimal design of data products as well as their efficient translation and commercialization. As surgery continues to evolve through advances in technology that enhance delivery of care, SDS represents a new knowledge domain to engineer surgical care of the future. PMID:28936475

Surgical data science: The new knowledge domain.

PubMed

Vedula, S Swaroop; Hager, Gregory D

2017-04-01

Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care. We foresee the emergence of Surgical/Interventional Data Science (SDS) as a key element to addressing these limitations and creating a sustainable path toward evidence-based improvement of interventional healthcare pathways. SDS will create tools to measure, model and quantify the pathways or processes within the context of patient health states or outcomes, and use information gained to inform healthcare decisions, guidelines, best practices, policy, and training, thereby improving the safety and quality of healthcare and its value. Data is pervasive throughout the surgical care pathway; thus, SDS can impact various aspects of care including prevention, diagnosis, intervention, or post-operative recovery. Existing literature already provides preliminary results suggesting how a data science approach to surgical decision-making could more accurately predict severe complications using complex data from pre-, intra-, and post-operative contexts, how it could support intra-operative decision-making using both existing knowledge and continuous data streams throughout the surgical care pathway, and how it could enable effective collaboration between human care providers and intelligent technologies. In addition, SDS is poised to play a central role in surgical education, for example, through objective assessments, automated virtual coaching, and robot-assisted active learning of surgical skill. However, the potential for transforming surgical care and training through SDS may only be realized through a cultural shift that not only institutionalizes technology to seamlessly capture data but also assimilates individuals with expertise in data science into clinical research teams. Furthermore, collaboration with industry partners from the inception of the discovery process promotes optimal design of data products as well as their efficient translation and commercialization. As surgery continues to evolve through advances in technology that enhance delivery of care, SDS represents a new knowledge domain to engineer surgical care of the future.

Social science in the national park service: an evolving mission and program

Treesearch

Richard H. Briceland

1992-01-01

In 1988 the director of the National Park Service requested that a social science program be established. Since that time a number of new research initiatives have been developed to address this need. This paper describes seven major steps taken thus far to meet social science needs of park superintendents, program managers, and park planners. Specific examples are...

The Moon: Been there, done that?

NASA Technical Reports Server (NTRS)

Cohen, Barbara

2013-01-01

Lunar science is planetary science. Lunar samples teach us about the formation and evolution of the Moon, and the history of all the planets. The Moon is a cornerstone for all rocky planets, since it formed and evolved similarly to Earth, Mars, Mercury, Venus, and large asteroids. Lunar robotic missions provide important science and engineering objectives, and keep our eyes on the Moon.

NASA's Earth Science Data Systems Standards Process Experiences

NASA Technical Reports Server (NTRS)

Ullman, Richard E.; Enloe, Yonsook

2007-01-01

NASA has impaneled several internal working groups to provide recommendations to NASA management on ways to evolve and improve Earth Science Data Systems. One of these working groups is the Standards Process Group (SPC). The SPG is drawn from NASA-funded Earth Science Data Systems stakeholders, and it directs a process of community review and evaluation of proposed NASA standards. The working group's goal is to promote interoperability and interuse of NASA Earth Science data through broader use of standards that have proven implementation and operational benefit to NASA Earth science by facilitating the NASA management endorsement of proposed standards. The SPC now has two years of experience with this approach to identification of standards. We will discuss real examples of the different types of candidate standards that have been proposed to NASA's Standards Process Group such as OPeNDAP's Data Access Protocol, the Hierarchical Data Format, and Open Geospatial Consortium's Web Map Server. Each of the three types of proposals requires a different sort of criteria for understanding the broad concepts of "proven implementation" and "operational benefit" in the context of NASA Earth Science data systems. We will discuss how our Standards Process has evolved with our experiences with the three candidate standards.

Evolution of Research Universities as a National Research System in Korea: Accomplishments and Challenges

ERIC Educational Resources Information Center

Shin, Jung Cheol; Lee, Soo Jeung

2015-01-01

This article focuses on South Korea, where the basis of the economy rapidly transformed from labor-intensive industries to heavy/chemical industries and then to technology-based industries within a short time period. The Korean case shows how national research systems evolve along with economic development. On the other hand, such rapid research…

Science and film-making.

PubMed

Gouyon, Jean-Baptiste

2016-01-01

The essay reviews the literature, mostly historical, on the relationship between science and film-making, with a focus on the science documentary. It then discusses the circumstances of the emergence of the wildlife making-of documentary genre. The thesis examined here is that since the early days of cinema, film-making has evolved from being subordinate to science, to being an equal partner in the production of knowledge, controlled by non-scientists. © The Author(s) 2015.

Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris

DOE PAGES

Zhou, Aifen; Hillesland, Kristina L.; He, Zhili; ...

2015-04-07

To investigate the genetic basis of microbial evolutionary adaptation to salt (NaCl) stress, populations of Desulfovibrio vulgaris Hildenborough (DvH), a sulfate-reducing bacterium important for the biogeochemical cycling of sulfur, carbon and nitrogen, and potentially the bioremediation of toxic heavy metals and radionuclides, were propagated under salt stress or non-stress conditions for 1200 generations. Whole-genome sequencing revealed 11 mutations in salt stress-evolved clone ES9-11 and 14 mutations in non-stress-evolved clone EC3-10. Whole-population sequencing data suggested the rapid selective sweep of the pre-existing polymorphisms under salt stress within the first 100 generations and the slow fixation of new mutations. Population genotyping datamore » demonstrated that the rapid selective sweep of pre-existing polymorphisms was common in salt stress-evolved populations. In contrast, the selection of pre-existing polymorphisms was largely random in EC populations. Consistently, at 100 generations, stress-evolved population ES9 showed improved salt tolerance, namely increased growth rate (2.0-fold), higher biomass yield (1.8-fold) and shorter lag phase (0.7-fold) under higher salinity conditions. The beneficial nature of several mutations was confirmed by site-directed mutagenesis. All four tested mutations contributed to the shortened lag phases under higher salinity condition. In particular, compared with the salt tolerance improvement in ES9-11, a mutation in a histidine kinase protein gene lytS contributed 27% of the growth rate increase and 23% of the biomass yield increase while a mutation in hypothetical gene DVU2472 contributed 24% of the biomass yield increase. In conclusion, our results suggested that a few beneficial mutations could lead to dramatic improvements in salt tolerance.« less

Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Aifen; Hillesland, Kristina L.; He, Zhili

To investigate the genetic basis of microbial evolutionary adaptation to salt (NaCl) stress, populations of Desulfovibrio vulgaris Hildenborough (DvH), a sulfate-reducing bacterium important for the biogeochemical cycling of sulfur, carbon and nitrogen, and potentially the bioremediation of toxic heavy metals and radionuclides, were propagated under salt stress or non-stress conditions for 1200 generations. Whole-genome sequencing revealed 11 mutations in salt stress-evolved clone ES9-11 and 14 mutations in non-stress-evolved clone EC3-10. Whole-population sequencing data suggested the rapid selective sweep of the pre-existing polymorphisms under salt stress within the first 100 generations and the slow fixation of new mutations. Population genotyping datamore » demonstrated that the rapid selective sweep of pre-existing polymorphisms was common in salt stress-evolved populations. In contrast, the selection of pre-existing polymorphisms was largely random in EC populations. Consistently, at 100 generations, stress-evolved population ES9 showed improved salt tolerance, namely increased growth rate (2.0-fold), higher biomass yield (1.8-fold) and shorter lag phase (0.7-fold) under higher salinity conditions. The beneficial nature of several mutations was confirmed by site-directed mutagenesis. All four tested mutations contributed to the shortened lag phases under higher salinity condition. In particular, compared with the salt tolerance improvement in ES9-11, a mutation in a histidine kinase protein gene lytS contributed 27% of the growth rate increase and 23% of the biomass yield increase while a mutation in hypothetical gene DVU2472 contributed 24% of the biomass yield increase. In conclusion, our results suggested that a few beneficial mutations could lead to dramatic improvements in salt tolerance.« less

Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Aifen; Hillesland, Kristina L.; He, Zhili

To investigate the genetic basis of microbial evolutionary adaptation to salt (NaCl) stress, populations of Desulfovibrio vulgaris Hildenborough (DvH), a sulfate-reducing bacterium important for the biogeochemical cycling of sulfur, carbon and nitrogen, and potentially the bioremediation of toxic heavy metals and radionuclides, were propagated under salt stress or non-stress conditions for 1200 generations. Whole-genome sequencing revealed 11 mutations in salt stress-evolved clone ES9-11 and 14 mutations in non-stress-evolved clone EC3-10. Whole-population sequencing data suggested the rapid selective sweep of the pre-existing polymorphisms under salt stress within the first 100 generations and the slow fixation of new mutations. Population genotyping datamore » demonstrated that the rapid selective sweep of pre-existing polymorphisms was common in salt stress-evolved populations. In contrast, the selection of pre-existing polymorphisms was largely random in EC populations. Consistently, at 100 generations, stress-evolved population ES9 showed improved salt tolerance, namely increased growth rate (2.0-fold), higher biomass yield (1.8-fold) and shorter lag phase (0.7-fold) under higher salinity conditions. The beneficial nature of several mutations was confirmed by site-directed mutagenesis. All four tested mutations contributed to the shortened lag phases under higher salinity condition. In particular, compared with the salt tolerance improvement in ES9-11, a mutation in a histidine kinase protein gene lytS contributed 27% of the growth rate increase and 23% of the biomass yield increase while a mutation in hypothetical gene DVU2472 contributed 24% of the biomass yield increase. Our results suggested that a few beneficial mutations could lead to dramatic improvements in salt tolerance.« less

Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris.

PubMed

Zhou, Aifen; Hillesland, Kristina L; He, Zhili; Schackwitz, Wendy; Tu, Qichao; Zane, Grant M; Ma, Qiao; Qu, Yuanyuan; Stahl, David A; Wall, Judy D; Hazen, Terry C; Fields, Matthew W; Arkin, Adam P; Zhou, Jizhong

2015-11-01

To investigate the genetic basis of microbial evolutionary adaptation to salt (NaCl) stress, populations of Desulfovibrio vulgaris Hildenborough (DvH), a sulfate-reducing bacterium important for the biogeochemical cycling of sulfur, carbon and nitrogen, and potentially the bioremediation of toxic heavy metals and radionuclides, were propagated under salt stress or non-stress conditions for 1200 generations. Whole-genome sequencing revealed 11 mutations in salt stress-evolved clone ES9-11 and 14 mutations in non-stress-evolved clone EC3-10. Whole-population sequencing data suggested the rapid selective sweep of the pre-existing polymorphisms under salt stress within the first 100 generations and the slow fixation of new mutations. Population genotyping data demonstrated that the rapid selective sweep of pre-existing polymorphisms was common in salt stress-evolved populations. In contrast, the selection of pre-existing polymorphisms was largely random in EC populations. Consistently, at 100 generations, stress-evolved population ES9 showed improved salt tolerance, namely increased growth rate (2.0-fold), higher biomass yield (1.8-fold) and shorter lag phase (0.7-fold) under higher salinity conditions. The beneficial nature of several mutations was confirmed by site-directed mutagenesis. All four tested mutations contributed to the shortened lag phases under higher salinity condition. In particular, compared with the salt tolerance improvement in ES9-11, a mutation in a histidine kinase protein gene lytS contributed 27% of the growth rate increase and 23% of the biomass yield increase while a mutation in hypothetical gene DVU2472 contributed 24% of the biomass yield increase. Our results suggested that a few beneficial mutations could lead to dramatic improvements in salt tolerance.

Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris

PubMed Central

Zhou, Aifen; Hillesland, Kristina L; He, Zhili; Schackwitz, Wendy; Tu, Qichao; Zane, Grant M; Ma, Qiao; Qu, Yuanyuan; Stahl, David A; Wall, Judy D; Hazen, Terry C; Fields, Matthew W; Arkin, Adam P; Zhou, Jizhong

2015-01-01

To investigate the genetic basis of microbial evolutionary adaptation to salt (NaCl) stress, populations of Desulfovibrio vulgaris Hildenborough (DvH), a sulfate-reducing bacterium important for the biogeochemical cycling of sulfur, carbon and nitrogen, and potentially the bioremediation of toxic heavy metals and radionuclides, were propagated under salt stress or non-stress conditions for 1200 generations. Whole-genome sequencing revealed 11 mutations in salt stress-evolved clone ES9-11 and 14 mutations in non-stress-evolved clone EC3-10. Whole-population sequencing data suggested the rapid selective sweep of the pre-existing polymorphisms under salt stress within the first 100 generations and the slow fixation of new mutations. Population genotyping data demonstrated that the rapid selective sweep of pre-existing polymorphisms was common in salt stress-evolved populations. In contrast, the selection of pre-existing polymorphisms was largely random in EC populations. Consistently, at 100 generations, stress-evolved population ES9 showed improved salt tolerance, namely increased growth rate (2.0-fold), higher biomass yield (1.8-fold) and shorter lag phase (0.7-fold) under higher salinity conditions. The beneficial nature of several mutations was confirmed by site-directed mutagenesis. All four tested mutations contributed to the shortened lag phases under higher salinity condition. In particular, compared with the salt tolerance improvement in ES9-11, a mutation in a histidine kinase protein gene lytS contributed 27% of the growth rate increase and 23% of the biomass yield increase while a mutation in hypothetical gene DVU2472 contributed 24% of the biomass yield increase. Our results suggested that a few beneficial mutations could lead to dramatic improvements in salt tolerance. PMID:25848870

Electronic nicotine delivery devices, and their impact on health and patterns of tobacco use: a systematic review protocol.

PubMed

Glasser, Allison M; Cobb, Caroline O; Teplitskaya, Lyubov; Ganz, Ollie; Katz, Lauren; Rose, Shyanika W; Feirman, Shari; Villanti, Andrea C

2015-04-29

E-cigarettes or electronic nicotine delivery systems (ENDS) have recently attracted considerable attention. Among some individuals there is strong debate and a polarisation of views about the public health benefits versus harms of ENDS. With little regulation, the ENDS market is evolving, and new products are introduced and marketed constantly. Rapid developments in manufacturing, marketing and consumer domains related to ENDS will warrant frequent re-evaluation, based on the state of the evolving science. The purpose of this article is to describe a protocol for an ongoing comprehensive review of the published scientific literature on ENDS. We will undertake a systematic review of published empirical research literature on ENDS using the National Library of Medicine's PubMed electronic database to search for relevant articles. Data from included studies will be extracted into a standardised form, tables with study details and key outcomes for each article will be created, and studies will be synthesised qualitatively. This review synthesises published literature and presents no primary data. Therefore, no ethical approval is required for this study. Subsequent papers will provide greater detail on results, within select categories, that represent gaps in the literature base. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Psychology in cognitive science: 1978-2038.

PubMed

Gentner, Dedre

2010-07-01

This paper considers the past and future of Psychology within Cognitive Science. In the history section, I focus on three questions: (a) how has the position of Psychology evolved within Cognitive Science, relative to the other disciplines that make up Cognitive Science; (b) how have particular Cognitive Science areas within Psychology waxed or waned; and (c) what have we gained and lost. After discussing what's happened since the late 1970s, when the Society and the journal began, I speculate about where the field is going. Copyright © 2010 Cognitive Science Society, Inc.

Evolving Communicative Complexity: Insight from Rodents and Beyond

DTIC Science & Technology

2012-01-01

Group size in animal societies: the potential role of social and ecological limitations in the group-living fish , Paragobiodon xanthosomus. Ethology... Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA 2Human Research and Engineering Directorate, Perceptual Sciences...evolve is an active question in behavioural ecology . Sciurid rodents (ground squirrels, prairie dogs and marmots) provide an excellent model system for

A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

DOE PAGES

Schoville, Sean D.; Chen, Yolanda H.; Andersson, Martin N.; ...

2018-01-31

The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable climates during its global invasion, and, notably, to rapidly evolve insecticide resistance. To examine evidence of rapid evolutionary change, and to understand the genetic basis of herbivory and insecticide resistance, we tested for structural and functional genomic changes relative to other arthropod species using genome sequencing, transcriptomics, and community annotation. Two factors that might facilitate rapid evolutionary change include transposable elements, which comprise at least 17% of the genome andmore » are rapidly evolving compared to other Coleoptera, and high levels of nucleotide diversity in rapidly growing pest populations. Adaptations to plant feeding are evident in gene expansions and differential expression of digestive enzymes in gut tissues, as well as expansions of gustatory receptors for bitter tasting. Surprisingly, the suite of genes involved in insecticide resistance is similar to other beetles. Finally, duplications in the RNAi pathway might explain why Leptinotarsa decemlineata has high sensitivity to dsRNA. In conclusion, the L. decemlineata genome provides opportunities to investigate a broad range of phenotypes and to develop sustainable methods to control this widely successful pest.« less

A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schoville, Sean D.; Chen, Yolanda H.; Andersson, Martin N.

The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable climates during its global invasion, and, notably, to rapidly evolve insecticide resistance. To examine evidence of rapid evolutionary change, and to understand the genetic basis of herbivory and insecticide resistance, we tested for structural and functional genomic changes relative to other arthropod species using genome sequencing, transcriptomics, and community annotation. Two factors that might facilitate rapid evolutionary change include transposable elements, which comprise at least 17% of the genome andmore » are rapidly evolving compared to other Coleoptera, and high levels of nucleotide diversity in rapidly growing pest populations. Adaptations to plant feeding are evident in gene expansions and differential expression of digestive enzymes in gut tissues, as well as expansions of gustatory receptors for bitter tasting. Surprisingly, the suite of genes involved in insecticide resistance is similar to other beetles. Finally, duplications in the RNAi pathway might explain why Leptinotarsa decemlineata has high sensitivity to dsRNA. In conclusion, the L. decemlineata genome provides opportunities to investigate a broad range of phenotypes and to develop sustainable methods to control this widely successful pest.« less

A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae).

PubMed

Schoville, Sean D; Chen, Yolanda H; Andersson, Martin N; Benoit, Joshua B; Bhandari, Anita; Bowsher, Julia H; Brevik, Kristian; Cappelle, Kaat; Chen, Mei-Ju M; Childers, Anna K; Childers, Christopher; Christiaens, Olivier; Clements, Justin; Didion, Elise M; Elpidina, Elena N; Engsontia, Patamarerk; Friedrich, Markus; García-Robles, Inmaculada; Gibbs, Richard A; Goswami, Chandan; Grapputo, Alessandro; Gruden, Kristina; Grynberg, Marcin; Henrissat, Bernard; Jennings, Emily C; Jones, Jeffery W; Kalsi, Megha; Khan, Sher A; Kumar, Abhishek; Li, Fei; Lombard, Vincent; Ma, Xingzhou; Martynov, Alexander; Miller, Nicholas J; Mitchell, Robert F; Munoz-Torres, Monica; Muszewska, Anna; Oppert, Brenda; Palli, Subba Reddy; Panfilio, Kristen A; Pauchet, Yannick; Perkin, Lindsey C; Petek, Marko; Poelchau, Monica F; Record, Éric; Rinehart, Joseph P; Robertson, Hugh M; Rosendale, Andrew J; Ruiz-Arroyo, Victor M; Smagghe, Guy; Szendrei, Zsofia; Thomas, Gregg W C; Torson, Alex S; Vargas Jentzsch, Iris M; Weirauch, Matthew T; Yates, Ashley D; Yocum, George D; Yoon, June-Sun; Richards, Stephen

2018-01-31

The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable climates during its global invasion, and, notably, to rapidly evolve insecticide resistance. To examine evidence of rapid evolutionary change, and to understand the genetic basis of herbivory and insecticide resistance, we tested for structural and functional genomic changes relative to other arthropod species using genome sequencing, transcriptomics, and community annotation. Two factors that might facilitate rapid evolutionary change include transposable elements, which comprise at least 17% of the genome and are rapidly evolving compared to other Coleoptera, and high levels of nucleotide diversity in rapidly growing pest populations. Adaptations to plant feeding are evident in gene expansions and differential expression of digestive enzymes in gut tissues, as well as expansions of gustatory receptors for bitter tasting. Surprisingly, the suite of genes involved in insecticide resistance is similar to other beetles. Finally, duplications in the RNAi pathway might explain why Leptinotarsa decemlineata has high sensitivity to dsRNA. The L. decemlineata genome provides opportunities to investigate a broad range of phenotypes and to develop sustainable methods to control this widely successful pest.

Three Conceptions of Thermodynamics: Technical Matrices in Science and Engineering

ERIC Educational Resources Information Center

Christiansen, Frederik V.; Rump, Camilla

2008-01-01

Introductory thermodynamics is a topic which is covered in a wide variety of science and engineering educations. However, very different teaching traditions have evolved within different scientific specialties. In this study we examine three courses in introductory thermodynamics within three different scientific specialties: physics, chemical…

Relaxed selection is a precursor to the evolution of phenotypic plasticity.

PubMed

Hunt, Brendan G; Ometto, Lino; Wurm, Yannick; Shoemaker, DeWayne; Yi, Soojin V; Keller, Laurent; Goodisman, Michael A D

2011-09-20

Phenotypic plasticity allows organisms to produce alternative phenotypes under different conditions and represents one of the most important ways by which organisms adaptively respond to the environment. However, the relationship between phenotypic plasticity and molecular evolution remains poorly understood. We addressed this issue by investigating the evolution of genes associated with phenotypically plastic castes, sexes, and developmental stages of the fire ant Solenopsis invicta. We first determined if genes associated with phenotypic plasticity in S. invicta evolved at a rapid rate, as predicted under theoretical models. We found that genes differentially expressed between S. invicta castes, sexes, and developmental stages all exhibited elevated rates of evolution compared with ubiquitously expressed genes. We next investigated the evolutionary history of genes associated with the production of castes. Surprisingly, we found that orthologs of caste-biased genes in S. invicta and the social bee Apis mellifera evolved rapidly in lineages without castes. Thus, in contrast to some theoretical predictions, our results suggest that rapid rates of molecular evolution may not arise primarily as a consequence of phenotypic plasticity. Instead, genes evolving under relaxed purifying selection may more readily adopt new forms of biased expression during the evolution of alternate phenotypes. These results suggest that relaxed selective constraint on protein-coding genes is an important and underappreciated element in the evolutionary origin of phenotypic plasticity.

Evolved Gas Measurements Planned for the Lower Layers of the Gale Crater Mound with the Sample Analysis at Mars Instrument Suite

NASA Astrophysics Data System (ADS)

Mahaffy, P. R.; Franz, H.; McAdam, A.; Conrad, P. G.; Brunner, A.; Cabane, M.; Webster, C. R.

2011-12-01

The lower mound strata of Gale Crater provide a diverse set of chemical environments for exploration by the varied tools of the Curiosity Rover of the Mars Science Laboratory (MSL) Mission. Orbital imaging and spectroscopy clearly reveal distinct layers of hydrated minerals, sulfates, and clays with abundant evidence of a variety of fluvial processes. The three instruments of the MSL Sample Analysis at Mars (SAM) investigation, the Quadrupole Mass Spectrometer (QMS), the Tunable Laser Spectrometer (TLS), and the Gas Chromatograph (GC) are designed to analyze either atmospheric gases or volatiles thermally evolved or chemically extracted from powdered rock or soil. The presence or absence of organic compounds in these layers is of great interest since such an in situ search for this type of record has not been successfully implemented since the mid-70s Viking GCMS experiments. However, regardless of the outcome of the analysis for organics, the abundance and isotopic composition of thermally evolved inorganic compounds should also provide a rich data set to complement the mineralogical and elemental information provided by other MSL instruments. In addition, these evolved gas analysis (EGA) experiments will help test sedimentary models proposed by Malin and Edgett (2000) and then further developed by Milliken et al (2010) for Gale Crater. In the SAM EGA experiments the evolution temperatures of H2O, CO2, SO2, O2, or other simple compounds as the samples are heated in a helium stream to 1000C provides information on mineral types and their associations. The isotopic composition of O, H, C, and S can be precisely determined in several evolved compounds and compared with the present day atmosphere. Such SAM results might be able to test mineralogical evidence of changing sedimentary and alteration processes over an extended period of time. For example, Bibring et al (2006) have suggested such a major shift from early nonacidic to later acidic alteration. We will illustrate through a variety of evolved gas experiments implemented under SAM-like gas flow and temperature ramp conditions on terrestrial analog minerals on high fidelity SAM breadboards the type of chemical information we expect SAM to provide. Bibring, J.-P., et al. (2006), Global mineralogical and aqueous Mars history derived from OMEGA/Mars Express data, Science, 312, 400-404, doi:10.1126/science.1122659. Malin, M. C., and K. S. Edgett (2000), Sedimentary rocks of early Mars, Science, 290, 1927-1937, doi:10.1126/science.290.5498.1927. Milliken, R. E., J. P. Grotzinger, and B. J. Thomson (2010), Paleoclimate of Mars as captured by the strati- graphic record in Gale Crater, Geophys. Res. Lett., 37, L04201, doi:10.1029/2009GL041870.

More rapid climate change promotes evolutionary rescue through selection for increased dispersal distance.

PubMed

Boeye, Jeroen; Travis, Justin M J; Stoks, Robby; Bonte, Dries

2013-02-01

Species can either adapt to new conditions induced by climate change or shift their range in an attempt to track optimal environmental conditions. During current range shifts, species are simultaneously confronted with a second major anthropogenic disturbance, landscape fragmentation. Using individual-based models with a shifting climate window, we examine the effect of different rates of climate change on the evolution of dispersal distances through changes in the genetically determined dispersal kernel. Our results demonstrate that the rate of climate change is positively correlated to the evolved dispersal distances although too fast climate change causes the population to crash. When faced with realistic rates of climate change, greater dispersal distances evolve than those required for the population to keep track of the climate, thereby maximizing population size. Importantly, the greater dispersal distances that evolve when climate change is more rapid, induce evolutionary rescue by facilitating the population in crossing large gaps in the landscape. This could ensure population persistence in case of range shifting in fragmented landscapes. Furthermore, we highlight problems in using invasion speed as a proxy for potential range shifting abilities under climate change.

Research and Teaching: The Pairing of a Science Communications and a Language Course to Enrich First-Year English Language Learners' Writing and Argumentation Skills

ERIC Educational Resources Information Center

Welsh, Ashley J.; Shaw, Amber; Fox, Joanne A.

2017-01-01

This article explores how English-language learners' writing evolved during a first-year seminar in science course aimed at developing students' argumentation skills. We highlight how a science communications course was paired with a weekly academic English course in the context of a highly coordinated and enriched first-year experience program…

Complexity science and leadership in healthcare.

PubMed

Burns, J P

2001-10-01

The emerging field of complexity science offers an alternative leadership strategy for the chaotic, complex healthcare environment. A survey revealed that healthcare leaders intuitively support principles of complexity science. Leadership that uses complexity principles offers opportunities in the chaotic healthcare environment to focus less on prediction and control and more on fostering relationships and creating conditions in which complex adaptive systems can evolve to produce creative outcomes.

A story of microalbuminuria and diabetic nephropathy

PubMed Central

Roshan, Bijan; Stanton, Robert C.

2013-01-01

Context: It is estimated that more than 346 million people worldwide have diabetes mellitus . By the year 2030, it is predicted that diabetes will become the seventh leading cause of death in the world. Development of chronic kidney disease (CKD) in patients with diabetes adds significantly to the morbidity and mortality and significantly increases health care costs, even before the development of end stage renal disease (ESRD). Evidence  acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: Diabetic nephropathy (DN) is increasing rapidly worldwide. It is the leading cause of new cases of ESRD in the USA.  Interestingly, although DN is the most common cause of ESRD in diabetic patients, diabetes mellitus is also an independent and strong risk factor for ESRD ascribed to causes other than DN (e.g. hypertensive nephropathy). Conclusions: It is important to be aware of the pitfalls of using the urine albumin level in predicting development and progression of diabetic nephropathy in order to treat and advise the patients accurately.  Research into finding new markers is rapidly evolving but current progress makes it likely we will be using the urine albumin level for some years into the future. PMID:24475455

Reactive control and reasoning assistance for scientific laboratory instruments

NASA Technical Reports Server (NTRS)

Thompson, David E.; Levinson, Richard; Robinson, Peter

1993-01-01

Scientific laboratory instruments that are involved in chemical or physical sample identification frequently require substantial human preparation, attention, and interactive control during their operation. Successful real-time analysis of incoming data that supports such interactive control requires: (1) a clear recognition of variance of the data from expected results; and (2) rapid diagnosis of possible alternative hypotheses which might explain the variance. Such analysis then aids in decisions about modifying the experiment protocol, as well as being a goal itself. This paper reports on a collaborative project at the NASA Ames Research Center between artificial intelligence researchers and planetary microbial ecologists. Our team is currently engaged in developing software that autonomously controls science laboratory instruments and that provides data analysis of the real-time data in support of dynamic refinement of the experiment control. the first two instruments to which this technology has been applied are a differential thermal analyzer (DTA) and a gas chromatograph (GC). coupled together, they form a new geochemicstry and microbial analysis tool that is capable of rapid identification of the organiz and mineralogical constituents in soils. The thermal decomposition of the minerals and organics, and the attendance release of evolved gases, provides data about the structural and molecular chemistry of the soil samples.

Applications of AOPs to ecotoxicology | Science Inventory | US ...

EPA Pesticide Factsheets

Toxicologists conducting safety assessments for either human or ecological health are responsible for generating data for possible adverse effects of a rapidly increasing number of substances. For example, the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) program in Europe, and the recent reauthorization of the Toxic Substances Control Act (TSCA) in the United States (US) both explicitly mandate consideration of the potential toxicity of many thousands of chemicals that, in the past, would not have been assessed. There also is an increasing emphasis on understanding the effects of existing chemical mixtures on human health and the environment; for example in North America, the Great Lakes Restoration Initiative, sponsored by the Office of the President of the US, has identified complex mixtures of chemicals of emerging concern as one of the highest priority stressors in the lakes. These types of new regulatory programs and monitoring initiatives highlight the necessity of identifying and developing novel, rapid approaches for assessing the potential toxicity of substances, to augment (or, in some instances, replace) the more costly, long-term in vivo test methods that historically have supported chemical risk assessments. Fortunately, these chemical evaluation challenges are occurring against a backdrop of evolving data collection and analysis techniques that enable generation of biological information in manners previously conside

Digital Direct-to-Consumer Advertising: A Perfect Storm of Rapid Evolution and Stagnant Regulation

PubMed Central

Mackey, Tim K.

2016-01-01

The adoption and use of digital forms of direct-to-consumer advertising (also known as "eDTCA") is on the rise. At the same time, the universe of eDTCA is expanding, as technology on Internet-based platforms continues to evolve, from static websites, to social media, and nearly ubiquitous use of mobile devices. However, little is known about how this unique form of pharmaceutical marketing impacts consumer behavior, public health, and overall healthcare utilization. The study by Kim analyzing US Food and Drug Administration (FDA) notices of violations (NOVs) and warning letters regarding online promotional activities takes us in the right direction, but study results raise as many questions as it does answers. Chief among these are unanswered concerns about the unique regulatory challenges posed by the "disruptive" qualities of eDTCA, and whether regulators have sufficient resources and oversight powers to proactively address potential violations. Further, the globalization of eDTCA via borderless Internet-based technologies raises larger concerns about the potential global impact of this form of health marketing unique to only the United States and New Zealand. Collectively, these challenges make it unlikely that regulatory science will be able to keep apace with the continued rapid evolution of eDTCA unless more creative policy solutions are explored. PMID:27239871

Blast-Wave Generation and Propagation in Rapidly Heated Laser-Irradiated Targets

NASA Astrophysics Data System (ADS)

Ivancic, S. T.; Stillman, C. R.; Nilson, P. M.; Solodov, A. A.; Froula, D. H.

2017-10-01

Time-resolved extreme ultraviolet (XUV) spectroscopy was used to study the creation and propagation of a >100-Mbar blast wave in a target irradiated by an intense (>1018WWcm2 cm2) laser pulse. Blast waves provide a platform to generate immense pressures in the laboratory. A temporal double flash of XUV radiation was observed when viewing the rear side of the target, which is attributed to the emergence of a blast wave following rapid heating by a fast-electron beam generated from the laser pulse. The time-history of XUV emission in the photon energy range of 50 to 200 eV was recorded with an x-ray streak camera with 7-ps temporal resolution. The heating and expansion of the target was simulated with an electron transport code coupled to 1-D radiation-hydrodynamics simulations. The temporal delay between the two flashes measured in a systematic study of target thickness and composition was found to evolve in good agreement with a Sedov-Taylor blast-wave solution. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944 and Department of Energy Office of Science Award Number DE-SC-0012317.

Darwin's foil: the evolving uses of William Paley's Natural Theology 1802-2005.

PubMed

Shapiro, Adam R

2014-03-01

This essay traces the divergent readings of William Paley's 1802 Natural Theology from its initial publication to the recent controversies over intelligent design. It argues that the misinterpretation of the Natural Theology as a scientific argument about the origins of complex life-which Darwin's Origin of Species refutes-did not develop all at once. Rather this reading evolved gradually, drawing from a variety of uses and appropriations during the course of the nineteenth and twentieth centuries. This study demonstrates the fluidity of "science" and "religion" during these centuries, and highlights the role that genres of science popularization play in altering the meaning of those categories. Copyright © 2013 Elsevier Ltd. All rights reserved.

Evolving Best Practice in Learning About Air Quality and Climate Change Science in ACCENT

NASA Astrophysics Data System (ADS)

Schuepbach, E.

2008-12-01

Learning about air quality and climate change science has developed into a transdisciplinary impact generator, moulded by academic-stakeholder partnerships, where complementary skills and competences lead to a culture of dialogue, mutual learning and decision-making. These sweeping changes are mirrored in the evolving best practice within the European Network of Excellence on Atmospheric Composition Change (ACCENT). The Training and Education Programme in ACCENT pursues an integrated approach and innovative avenues to sharing knowledge and communicating air quality and climate change science to various end-user groups, including teachers, policy makers, stakeholders, and the general public. Early career scientists are involved in the process, and are trained to acquire new knowledge in a variety of learning communities and environments. Here, examples of both the open system of teaching within ACCENT training workshops for early career scientists, and the engagement of non-academic audiences in the joint learning process are presented.

The interface theory of perception: the future of the science of the mind?

PubMed

Hickok, Gregory

2015-12-01

Perception is typically conceptualized as a neurocognitive system that evolved to reveal the truth about objects and events in the world. Hoffman et al.'s Interface Theory of Perception questions this assumption. If true, the implications for the science of the mind are profound.

A New Look at Creative Giftedness

ERIC Educational Resources Information Center

Lubart, Todd; Zenasni, Franck

2010-01-01

In the target article, "Where does creativity fit into a productivist industrial model of knowledge production?", Ghassib (2010) invites the reader to step back and consider some long term historical and socio-cultural trends concerning the field of science and its relationships to society. This perspective suggests that science has evolved to…

Learning Science as Explorers: Historical Resonances, Inventive Instruments, Evolving Community

ERIC Educational Resources Information Center

Cavicchi, Elizabeth

2014-01-01

Doing science as explorers, students observe, wonder and question the unknown, stretching their experience. To engage students as explorers depends on their safety in expressing uncertainty and taking risks. I create these conditions in my university seminar by employing critical exploration in the classroom, a pedagogy developed by Eleanor…

Using Machine Learning to Increase Research Efficiency: A New Approach in Environmental Sciences

USDA-ARS?s Scientific Manuscript database

Data collection has evolved from tedious in-person fieldwork to automatic data gathering from multiple sensor remotely. Scientist in environmental sciences have not fully exploited this data deluge, including legacy and new data, because the traditional scientific method is focused on small, high qu...

Computing Education in Korea--Current Issues and Endeavors

ERIC Educational Resources Information Center

Choi, Jeongwon; An, Sangjin; Lee, Youngjun

2015-01-01

Computer education has been provided for a long period of time in Korea. Starting as a vocational program, the content of computer education for students evolved to include content on computer literacy, Information Communication Technology (ICT) literacy, and brand-new computer science. While a new curriculum related to computer science was…

The Microscope and Nineteenth Century Education.

ERIC Educational Resources Information Center

Milacek, Barbara Roads

Studied were (1) the evolving use of the microscope in science education, and (2) its relationship to the changing teaching methods, content, and emphases of science courses and to the prevailing philosophies of education of nineteenth century American colleges. To establish the necessary background, the evolution and availability of the…

Supporting STEM Teachers to Inspire through Everyday Innovation

ERIC Educational Resources Information Center

Bienkowski, Marie; Shechtman, Nicole; Remold, Julie; Knudsen, Jennifer

2014-01-01

Science teachers inspire in part by their constant adaptation to the learning needs of their students and to evolving content, curriculum, technology, and student populations. Innovation--bringing novel things to a situation to confer a benefit--is an integral part of teaching overall, and in especially inspired science teaching. While innovation…

Evolving approaches toward science based forest management.

Treesearch

Robert C. Szaro; Charles E. Peterson

2004-01-01

The sale, scope, and complexity of natural resource and environmental issues have dramatically increased, yet the urgency to solve these issues often requires immediate information that spans disciplinary boundaries, synthesizes material from a variety of sources, draws inferences, and identifies levels of confidence. Although science information and knowledge are only...

The "Post-Post Period" and Environmental Education Research

ERIC Educational Resources Information Center

McKenzie, Marcia

2005-01-01

Described as "post-experimental" and of the "post-post period," the current moment in social science research is typified by multi-voiced texts, researcher reflexivity, cultural criticism, and experimental works; characteristics in keeping with post-structurally informed understandings of social science research as contingent, evolving and messy.…

Second interim briefing (D3). Evolutionary Science and Applications Space Platform. Characterization of concepts, tasks A and B

NASA Technical Reports Server (NTRS)

1981-01-01

The objectives were to define, evaluate, and select concepts for evolving a space station in conjunction with the Space Platform for NASA science, Applications, Technology and DOD; and a permanently manned presence in space early, with a maximum of existing technology.

Synthesis for the Interdisciplinary Environmental Sciences: Integrating Systems Approaches and Service Learning

ERIC Educational Resources Information Center

Simon, Gregory L.; Wee, Bryan Shao-Chang; Chin, Anne; Tindle, Amy Depierre; Guth, Dan; Mason, Hillary

2013-01-01

As our understanding of complex environmental issues increases, institutions of higher education are evolving to develop new learning models that emphasize synthesis across disciplines, concepts, data, and methodologies. To this end, we argue for the implementation of environmental science education at the intersection of systems theory and…

NASA's Earth Science Data Systems: A "Bit of History" and Observations

NASA Technical Reports Server (NTRS)

Ramapriyan, H. K.

2008-01-01

NASA has significantly improved its Earth Science Data Systems over the last two decades. Open data policy and inexpensive (or free) availability of data has promoted data usage by broad research and applications communities. Flexibility, accommodation of diversity, evolvability, responsiveness to community feedback are key to success.

CHEMICAL/BIOLOGICAL-CAPABLE RPA THREATS AND NATIONAL SECURITY IMPLICATIONS

DTIC Science & Technology

2016-02-07

iv Abstract The technological landscape of the 21st century is evolving at an ever-increasing pace . Autonomous remotely piloted...chemical and biological conventions must occur to address existing coverage gaps in an effort to keep pace with the ongoing advances of science and...21st century is evolving at an ever-increasing pace . Autonomous remotely piloted aircrafts (RPAs) continue to become increasingly sophisticated in

Musicality: instinct or acquired skill?

PubMed

Marcus, Gary F

2012-10-01

Is the human tendency toward musicality better thought of as the product of a specific, evolved instinct or an acquired skill? Developmental and evolutionary arguments are considered, along with issues of domain-specificity. The article also considers the question of why humans might be consistently and intensely drawn to music if musicality is not in fact the product of a specifically evolved instinct. Copyright © 2012 Cognitive Science Society, Inc.

Evolved Gas Analyses of the Murray Formation in Gale Crater, Mars: Results of the Curiosity Rover's Sample Analysis at Mars (SAM) Instrument

NASA Technical Reports Server (NTRS)

Sutter, B.; McAdam, A. C.; Rampe, E. B.; Thompson, L. M.; Ming, D. W.; Mahaffy, P. R.; Navarro-Gonzalez, R.; Stern, J. C.; Eigenbrode, J. L.; Archer, P. D.

2017-01-01

The Sample Analysis at Mars (SAM) instrument aboard the Mars Science Laboratory rover has analyzed 13 samples from Gale Crater. All SAM-evolved gas analyses have yielded a multitude of volatiles (e.g., H2O, SO2, H2S, CO2, CO, NO, O2, HCl) [1- 6]. The objectives of this work are to 1) Characterize recent evolved SO2, CO2, O2, and NO gas traces of the Murray formation mudstone, 2) Constrain sediment mineralogy/composition based on SAM evolved gas analysis (SAM-EGA), and 3) Discuss the implications of these results relative to understanding the geological history of Gale Crater.

The Pharmacology of Regenerative Medicine

PubMed Central

Saul, Justin M.; Furth, Mark E.; Andersson, Karl-Erik

2013-01-01

Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase “regenerative pharmacology” to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is “the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues.” As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all. PMID:23818131

Developing a problem-based learning (PBL) curriculum for professionalism and scientific integrity training for biomedical graduate students.

PubMed

Jones, Nancy L; Peiffer, Ann M; Lambros, Ann; Guthold, Martin; Johnson, A Daniel; Tytell, Michael; Ronca, April E; Eldridge, J Charles

2010-10-01

A multidisciplinary faculty committee designed a curriculum to shape biomedical graduate students into researchers with a high commitment to professionalism and social responsibility and to provide students with tools to navigate complex, rapidly evolving academic and societal environments with a strong ethical commitment. The curriculum used problem-based learning (PBL), because it is active and learner-centred and focuses on skill and process development. Two courses were developed: Scientific Professionalism: Scientific Integrity addressed discipline-specific and broad professional norms and obligations for the ethical practice of science and responsible conduct of research (RCR). Scientific Professionalism: Bioethics and Social Responsibility focused on current ethical and bioethical issues within the scientific profession, and implications of research for society. Each small-group session examined case scenarios that included: (1) learning objectives for professional norms and obligations; (2) key ethical issues and philosophies within each topic area; (3) one or more of the RCR instructional areas; and (4) at least one type of moral reflection. Cases emphasised professional standards, obligations and underlying philosophies for the ethical practice of science, competing interests of stakeholders and oversight of science (internal and external). To our knowledge, this is the first use of a longitudinal, multi-semester PBL course to teach scientific integrity and professionalism. Both faculty and students endorsed the active learning approach for these topics, in contrast to a compliance-based approach that emphasises learning rules and regulations.

NASA's Earth Observing Data and Information System - Near-Term Challenges

NASA Technical Reports Server (NTRS)

Behnke, Jeanne; Mitchell, Andrew; Ramapriyan, Hampapuram

2018-01-01

NASA's Earth Observing System Data and Information System (EOSDIS) has been a central component of the NASA Earth observation program since the 1990's. EOSDIS manages data covering a wide range of Earth science disciplines including cryosphere, land cover change, polar processes, field campaigns, ocean surface, digital elevation, atmosphere dynamics and composition, and inter-disciplinary research, and many others. One of the key components of EOSDIS is a set of twelve discipline-based Distributed Active Archive Centers (DAACs) distributed across the United States. Managed by NASA's Earth Science Data and Information System (ESDIS) Project at Goddard Space Flight Center, these DAACs serve over 3 million users globally. The ESDIS Project provides the infrastructure support for EOSDIS, which includes other components such as the Science Investigator-led Processing systems (SIPS), common metadata and metrics management systems, specialized network systems, standards management, and centralized support for use of commercial cloud capabilities. Given the long-term requirements, and the rapid pace of information technology and changing expectations of the user community, EOSDIS has evolved continually over the past three decades. However, many challenges remain. Challenges addressed in this paper include: growing volume and variety, achieving consistency across a diverse set of data producers, managing information about a large number of datasets, migration to a cloud computing environment, optimizing data discovery and access, incorporating user feedback from a diverse community, keeping metadata updated as data collections grow and age, and ensuring that all the content needed for understanding datasets by future users is identified and preserved.

Integrating anticipated nutrigenomics bioscience applications with ethical aspects.

PubMed

Lévesque, Lise; Ozdemir, Vural; Gremmen, Bart; Godard, Béatrice

2008-03-01

Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surrounding nutrigenomics face the challenges of a rapidly evolving field which bring forward the additional dimension of crossdisciplinary integrative research between social and biomedical sciences. This article outlines the emerging nutrigenomics definitions and concepts and analyzes the existing ethics literature concerning personalized nutrition and presents "points to consider" over ethical issues regarding future nutrigenomics applications. The interest in nutrigenomics coincides with a shift in emphasis in medicine and biosciences toward prevention of future disease susceptibilities rather than treatment of already established disease. Hence, unique ethical issues emerge concerning the extent to which nutrigenomics can alter our relation to food, boundaries between health and disease, and the folklore of medical practice. Nutrigenomics can result in new social values, norms, and responsibilities for both individuals and societies. Nutrigenomics is not only another new application of "-omics" technologies in the context of gene-diet interactions. Nutrigenomics may fundamentally change the way we perceive human illness while shifting the focus and broadening the scope of health interventions from patients to healthy individuals. In resource- and time-limited healthcare settings, this creates unique ethical dilemmas and distributive justice issues. Ethical aspects of nutrigenomics applications should be addressed proactively, as this new science develops and increasingly coalesces with other applications of genomics in medicine and public health.

Curricular Transformation in Health Systems Science: The Need for Global Change.

PubMed

Gonzalo, Jed D; Wolpaw, Terry; Wolpaw, Dan

2018-05-08

In this Invited Commentary, the authors propose a counter-perspective to the article by Borkan and colleagues, who advocate for a circumscribed, piloted, choice-focused approach to introducing curricular redesign options in undergraduate medical education, particularly in the area of health systems science. In making this case, Borkan and colleagues cluster several kinds of innovative curricular changes that the authors of this commentary believe are best separated by the scope of change and associated educational strategy: 1) innovations customized to student interest and motivation, which are best served by focused programmatic interventions, 2) innovations such as longitudinal integrated clerkships (LICs) that represent creative and needed educational strategies but may be difficult to expand due to complex barriers, and 3) innovations that are truly transformational, with critical connections far beyond the boundaries of the medical school curriculum, which must be addressed in a comprehensive approach-despite the challenges, frustrations, and difficulties. The authors situate health systems science squarely into the third category, and address three important questions addressing the nature and demands of this change. In making these arguments, the authors draw from experiences at the Penn State College of Medicine and collaborations with other U.S. medical schools related to large-scale curricular transformation and challenges that impact this change. The authors contend that medical education needs to navigate this major change for all students in a way that not only succeeds for learners but, more important, addresses the needs of patients seeking care in rapidly evolving systems of care.

Teaching Environmental Education through PBL: Evaluation of a Teaching Intervention Program

NASA Astrophysics Data System (ADS)

Vasconcelos, Clara

2012-04-01

If our chosen aim in science education is to be inclusive and to improve students' learning achievements, then we must identify teaching methodologies that are appropriate for teaching and learning specific knowledge. Karagiorgi and Symeo 2005) remind us that instructional designers are thus challenged to translate the philosophy of constructivism into current practice. Thus, research in science education must focus on evaluating intervention programs which ensure the effective construction of knowledge and development of competencies. The present study reports the elaboration, application and evaluation of a problem-based learning (PBL) program with the aim of examining its effectiveness with students learning Environmental Education. Prior research on both PBL and Environmental Education (EE) was conducted within the context of science education so as to elaborate and construct the intervention program. Findings from these studies indicated both the PBL methodology and EE as helpful for teachers and students. PBL methodology has been adopted in this study since it is logically incorporated in a constructivism philosophy application (Hendry et al. 1999) and it was expected that this approach would assist students towards achieving a specific set of competencies (Engel 1997). On the other hand, EE has evolved at a rapid pace within many countries in the new millennium (Hart 2007), unlike any other educational area. However, many authors still appear to believe that schools are failing to prepare students adequately in EE (Walsche 2008; Winter 2007). The following section describes the research that was conducted in both areas so as to devise the intervention program.

The evolution and extinction of science fiction.

PubMed

Hrotic, Steven

2014-11-01

Science fiction literature reflects our constantly evolving attitudes towards science and technological innovations, and the kinds of societal impacts believed possible. The newly popular subgenre 'steampunk' shows that these attitudes have significantly shifted. Examined from a cognitive anthropological perspective, science fiction reveals the cultural evolution of the genre as intelligently designed, and implies a cognitive mechanism of group membership reliant on implicit memory. However, such an analysis also suggests that genre science fiction as it was in the 20th century may no longer exist. © The Author(s) 2013.

The International Association of Hydrogeologists (IAH): reflecting on 60 years of contributions to groundwater science and water management

NASA Astrophysics Data System (ADS)

Struckmeier, Willi; Howard, Ken; Chilton, John

2016-08-01

The 60th anniversary of the founding of the International Association of Hydrogeologists (IAH) is an important milestone that allows pause for reflection on how the association has evolved over the years and the contributions it has made to groundwater science and water management. IAH was founded in 1956 at the 20th International Geological Congress and developed rapidly during the 1980s and 1990s in response to a growing global interest in groundwater mapping and in sound approaches to resource protection and sustainable aquifer management. Incorporated in 2000, IAH has now secured its position as the world's leading international association specialising in groundwater with over 4,100 members in 131 countries. Much credit for this success must go to members, past and present, whose individual efforts and collaboration with sister institutions are documented here. These members have shaped the association's goals and contributed selflessly to its scientific programmes, publications and educational and charitable activities. Looking ahead to the next 60 years, it is essential that IAH does not rest on past achievements but listens and adjusts to the needs of members while continuing to pursue its mission of furthering the understanding, wise use and protection of groundwater resources throughout the world.

Shape transitions during clathrin-induced endocytosis

NASA Astrophysics Data System (ADS)

Kumar, Gaurav; Sain, Anirban

2016-12-01

Endocytosis is among the most common transport mechanisms which cells employ to receive macromolecules, the so-called cargo, from its extra cellular environment. Clathrin-mediated endocytosis (CME), in particular, involves the cytoplasmic protein clathrin which induces formation and internalization of clathrin-coated membrane buds that contain extra-cellular cargo. Decades of experimental work have established that the morphology of the clathrin coat evolves with time and induces its curvature on the membrane bud; but energetics of the process remain unclear. Recent experiments by Avinoam et al. [Science 348, 1369 (2015), 10.1126/science.aaa9555] reported that the area of the clathrin coat remains fixed while its curvature increases with time and also the clathrin molecules in the coat turn over rapidly. We show that these observations challenge existing models of coated membrane bud formation. We analyze their data to bring out certain features consistent with the underlying lattice structure of the coat. We hypothesize that membrane curvature inhibits clathrin deposition and propose a kinetic model that explains the area distribution of clathrin coats. We also show that their data on shape evolution of the coated membrane bud can be approximately understood from simple geometric considerations. However, the energetics of the coat formation which controls the kinetics of the process remains a puzzle.

Freeze the Moment: High Speed Capturing of Weakly Bonded Dynamic Nanoparticle Assemblies in Solution by Ag Ion Soldering.

PubMed

Wang, Yueliang; Fang, Lingling; Chen, Gaoli; Song, Lei; Deng, Zhaoxiang

2018-02-01

Despite the versatile forms of colloidal aggregates, these spontaneously formed structures are often hard to find a suitable application in nanotechnology and materials science. A determinate reason is the lack of a suitable method to capture the transiently formed and quickly evolving colloidal structures in solution. To address this challenge, a simple but highly efficient strategy is herein reported to capture the dynamic and metastable colloidal assemblies formed in an aqueous or nonaqueous solution. This process takes advantage of a recently developed Ag ion soldering reaction to realize a rapid fixation of as-formed metastable assemblies. This method works efficiently for both solid (3D) nanoparticle aggregates and weakly bonded fractal nanoparticle chains (1D). In both cases, very high capturing speed and close to 100% efficiency are achieved to fully retain a quickly growing structure. The soldered nanochains further enable a fabrication of discrete, uniform, and functionalizable nanoparticle clusters with enriched linear conformation by mechanical shearing, which would otherwise be difficult to make. The captured products are water dispersible and mechanically robust, favoring an exploration of their properties toward possible applications. The work paves a way to previously untouched aspects of colloidal science and thus would create new chances in nanotechnology. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evolving Frameworks for Different Communities of Scientists and End Users

NASA Astrophysics Data System (ADS)

Graves, S. J.; Keiser, K.

2016-12-01

Two evolving frameworks for interdisciplinary science will be described in the context of the Common Data Framework for Earth-Observation Data and the importance of standards and protocols. The Event Data Driven Delivery (ED3) Framework, funded by NASA Applied Sciences, provides the delivery of data based on predetermined subscriptions and associated workflows to various communities of end users. ED3's capabilities are used by scientists, as well as policy and resource managers, when event alerts are triggered to respond to their needs. The EarthCube Integration and Testing Environment (ECITE) Assessment Framework for Technology Interoperability and Integration is being developed to facilitate the EarthCube community's assessment of NSF funded technologies addressing Earth science problems. ECITE is addressing the translation of geoscience researchers' use cases into technology use case that apply EarthCube-funded building block technologies (and other existing technologies) for solving science problems. EarthCube criteria for technology assessment include the use of data, metadata and service standards to improve interoperability and integration across program components. The long-range benefit will be the growth of a cyberinfrastructure with technology components that have been shown to work together to solve known science objectives.

China as an Evolving Metro-Agro-Plex (China-MAP)

NASA Technical Reports Server (NTRS)

Chameides, William L.; Bergin, M.; Carmichael, G.; Dickinson, R.; Giorgi, F.; Kiang, C. S.; Levy, H., II; Kasibhatla, P.; Mearns, L.; Ramaswamy, V.

2002-01-01

The one-year NASA-funded project was implemented to complete the analyses and model-simulations undertaken under the auspices of the 3-year research effort supported by NASA as an Interdisciplinary Earth System Science Investigation (IDS) entitled: China As An Evolving Metro-Agro-Plex (China-MAP). The primary goal of China-MAP was to assess the effects of economic development and the regional environmental changes it engenders upon agriculture in China. The project was carried out as part of the Sino-U.S. Science and Technology Protocol in the Atmospheric Sciences, an official government-to-government agreement that establishes the parameters for joint research projects between the two nations in the atmospheric sciences. The NASA-funded portion of the project focused on the development and application of a regional coupled climate/chemical transport model for East Asia (i.e., RegChem-CM). The funds provided under the subject 1-year project were used to: (1) complete specific investigations undertaken by the China-MAP Science Team using the Reg-Chem-CM expended; and (2) document the results of these and other China-MAP investigations in the peer-reviewed literature. A summary of these specific investigations in provided.

Evolutionary Design of an X-Band Antenna for NASA's Space Technology 5 Mission

NASA Technical Reports Server (NTRS)

Lohn, Jason D.; Hornby, Gregory S.; Rodriguez-Arroyo, Adan; Linden, Derek S.; Kraus, William F.; Seufert, Stephen E.

2003-01-01

We present an evolved X-band antenna design and flight prototype currently on schedule to be deployed on NASA s Space Technology 5 spacecraft in 2004. The mission consists of three small satellites that wall take science measurements in Earth s magnetosphere. The antenna was evolved to meet a challenging set of mission requirements, most notably the combination of wide beamwidth for a circularly-polarized wave and wide bandwidth. Two genetic algorithms were used: one allowed branching an the antenna arms and the other did not. The highest performance antennas from both algorithms were fabricated and tested. A handdesigned antenna was produced by the contractor responsible for the design and build of the mission antennas. The hand-designed antenna is a quadrifilar helix, and we present performance data for comparison to the evolved antennas. As of this writing, one of our evolved antenna prototypes is undergoing flight qualification testing. If successful, the resulting antenna would represent the first evolved hardware in space, and the first deployed evolved antenna.

Data Serving Climate Simulation Science at the NASA Center for Climate Simulation

NASA Technical Reports Server (NTRS)

Salmon, Ellen M.

2011-01-01

The NASA Center for Climate Simulation (NCCS) provides high performance computational resources, a multi-petabyte archive, and data services in support of climate simulation research and other NASA-sponsored science. This talk describes the NCCS's data-centric architecture and processing, which are evolving in anticipation of researchers' growing requirements for higher resolution simulations and increased data sharing among NCCS users and the external science community.

Effectiveness of Kanban Approaches in Systems Engineering within Rapid Response Environments

DTIC Science & Technology

2012-01-01

Procedia Computer Science Procedia Computer Science 00 (2012) 000–000 www.elsevier.com/locate/ procedia New Challenges in Systems...Author name / Procedia Computer Science 00 (2011) 000–000 inefficient use of resources. The move from ―one step to glory‖ system initiatives to...University of Science and Technology Effectiveness of kanban approaches in systems engineering within rapid response environments Richard Turner

Using an Integrated Approach to Supporting Climate Change Literacy for Pre-Service Teachers

NASA Astrophysics Data System (ADS)

Miller, H. R.; Mattox, S.; Llerandi-Román, P. A.; Dobson, C.

2014-12-01

Educating future Americans has long been a debate; with the Next Generation Science Standards (NGSS) now being adopted, climate literacy has become a more dominant discussion in both the classroom and in our society where climate education has often been non-existent or dismal at best. With these new education standards climate literacy is now fundamental to science education, this means understanding climate needs to begin with those headed into the classroom with these future Americans. These educators are expected to be skilled and confident in all subject areas, including science, where they might receive less training. To address this challenge, we have focused on an interdisciplinary approach to climate literacy, which is facilitated through cross-cutting concepts in both Earth and life sciences and parallels NGSS standards. We used the Yale Project on Climate Change Communication to gauge our student's strengths and weaknesses and compare them to the general public's understanding of climate change and complex Earth processes, such as beliefs about climate change, understanding the greenhouse effect, weather versus climate, climate change past and present, impacts and solutions. After a semester of this interdisciplinary course our students felt 95% confident that they are informed about global climate change as compared to 62% of Americans that were surveyed. Our students could define and describe greenhouse effect and 82% of them could classify greenhouse gases as compared to 66% and 45% of Americans respectively. While these non-science, education students were generally more knowledgeable about climate change, the areas where they did not significantly outperform the general public allowed us to refocus our course to aid them in understanding this complex issue where our hopes are that they will be prepared to teach science in their future classroom which will allow their students to be competitive in today's rapidly evolving global economy.

Exploring multiliteracies, student voice, and scientific practices in two elementary classrooms

NASA Astrophysics Data System (ADS)

Allison, Elizabeth Rowland

This study explored the voices of children in a changing world with evolving needs and new opportunities. The workplaces of rapidly moving capitalist societies value creativity, collaboration, and critical thinking skills which are of growing importance and manifesting themselves in modern K-12 science classroom cultures (Gee, 2000; New London Group, 2000). This study explored issues of multiliteracies and student voice set within the context of teaching and learning in 4th and 5th grade science classrooms. The purpose of the study was to ascertain what and how multiliteracies and scientific practices (NGSS Lead States, 2013c) are implemented, explore how multiliteracies influence students' voices, and investigate teacher and student perceptions of multiliteracies, student voice, and scientific practices. Grounded in a constructivist framework, a multiple case study was employed in two elementary classrooms. Through observations, student focus groups and interviews, and teacher interviews, a detailed narrative was created to describe a range of multiliteracies, student voice, and scientific practices that occurred with the science classroom context. Using grounded theory analysis, data were coded and analyzed to reveal emergent themes. Data analysis revealed that these two classrooms were enriched with multiliteracies that serve metaphorically as breeding grounds for student voice. In the modern classroom, defined as a space where information is instantly accessible through the Internet, multiliteracies can be developed through inquiry-based, collaborative, and technology-rich experiences. Scientific literacy, cultivated through student communication and collaboration, is arguably a multiliteracy that has not been considered in the literature, and should be, as an integral component of overall individual literacy in the 21st century. Findings revealed four themes. Three themes suggest that teachers address several modes of multiliteracies in science, but identify barriers to integrating multiliteracies and scientific practices into science teaching. The issues include time, increased standards accountability, and lack of comfort with effective integration of technology. The fourth theme revealed that students have the ability to shape and define their learning while supporting other voices through collaborative science experiences.

A case study of systemic curricular reform: A forty-year history

NASA Astrophysics Data System (ADS)

Laubach, Timothy Alan

What follows is a description of the development of a particular inquiry-based elementary school science curriculum program and how its theoretical underpinnings positively influenced a school district's (K-12) science program and also impacted district- and state-wide curriculum reform initiatives. The district's science program has evolved since the inception of the inquiry-based elementary school science curriculum reform forty years ago. Therefore, a historical case study, which incorporated grounded theory methodology, was used to convey the forty-year development of a science curriculum reform effort and its systemic influences. Data for this study were collected primarily through artifacts, such as technical and non-technical documents, and supported and augmented with interviews. Fifteen people comprised the interview consortium with professional responsibilities including (a) administrative roles, such as superintendents, assistant superintendents, principals, and curriculum consultants/coordinators; (b) classroom roles, such as elementary and secondary school teachers who taught science; (c) partnership roles, such as university faculty who collaborated with those in administrative and classroom positions within the district; and (d) the co-director of SCIS who worked with the SCIS trial center director. Data were analyzed and coded using the constant comparative method. The analysis of data uncovered five categories or levels in which the curriculum reform evolved throughout its duration. These themes are Initiation, Education, Implementation, Confirmation, and Continuation. These five categories lead to several working hypotheses that supported the sustaining and continuing of a K-12 science curriculum reform effort. These components are a committed visionary; a theory base of education; forums promoting the education of the theory base components; shared-decision making; a university-school partnership; a core group of committed educators and teachers; evidences of success; national and state reform initiatives; a core group of administrators; longevity of the science program; district support (philosophical, financial, and emotional); and community support all contributed to the initiation, education, implementation, confirmation, and the continuation of the systemic curricular reform. The underlying component, or grounded theory generated by the study, that ties these experiences together is the "theory base" that concurrently evolved in the local school district and in a nearby university.

Efficient Strategies for Active Interface-Level Network Topology Discovery

DTIC Science & Technology

2013-09-01

Network Information Centre API Application Programming Interface APNIC Asia-Pacific Network Information Centre ARIN American Registry for Internet Numbers...very convenient Application Programming Interface ( API ) for easy primitive implementation. Ark’s API facilitates easy development and rapid...prototyping – important attributes as the char- acteristics of our primitives evolve. The API allows a high-level of abstraction, which in turn leads to rapid

Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly.

PubMed

Aird, Steven D; Aggarwal, Shikha; Villar-Briones, Alejandro; Tin, Mandy Man-Ying; Terada, Kouki; Mikheyev, Alexander S

2015-08-28

While many studies have shown that extracellular proteins evolve rapidly, how selection acts on them remains poorly understood. We used snake venoms to understand the interaction between ecology, expression level, and evolutionary rate in secreted protein systems. Venomous snakes employ well-integrated systems of proteins and organic constituents to immobilize prey. Venoms are generally optimized to subdue preferred prey more effectively than non-prey, and many venom protein families manifest positive selection and rapid gene family diversification. Although previous studies have illuminated how individual venom protein families evolve, how selection acts on venoms as integrated systems, is unknown. Using next-generation transcriptome sequencing and mass spectrometry, we examined microevolution in two pitvipers, allopatrically separated for at least 1.6 million years, and their hybrids. Transcriptomes of parental species had generally similar compositions in regard to protein families, but for a given protein family, the homologs present and concentrations thereof sometimes differed dramatically. For instance, a phospholipase A2 transcript comprising 73.4 % of the Protobothrops elegans transcriptome, was barely present in the P. flavoviridis transcriptome (<0.05 %). Hybrids produced most proteins found in both parental venoms. Protein evolutionary rates were positively correlated with transcriptomic and proteomic abundances, and the most abundant proteins showed positive selection. This pattern holds with the addition of four other published crotaline transcriptomes, from two more genera, and also for the recently published king cobra genome, suggesting that rapid evolution of abundant proteins may be generally true for snake venoms. Looking more broadly at Protobothrops, we show that rapid evolution of the most abundant components is due to positive selection, suggesting an interplay between abundance and adaptation. Given log-scale differences in toxin abundance, which are likely correlated with biosynthetic costs, we hypothesize that as a result of natural selection, snakes optimize return on energetic investment by producing more of venom proteins that increase their fitness. Natural selection then acts on the additive genetic variance of these components, in proportion to their contributions to overall fitness. Adaptive evolution of venoms may occur most rapidly through changes in expression levels that alter fitness contributions, and thus the strength of selection acting on specific secretome components.

E-Learning in Science and Technology via a Common Learning Platform in a Lifelong Learning Project

ERIC Educational Resources Information Center

Priem, Freddy; De Craemer, Renaat; Calu, Johan; Pedreschi, Fran; Zimmer, Thomas; Saighi, Sylvain; Lilja, Jarmo

2011-01-01

This three-year Virtual Measurements Environment curriculum development project for higher education within the Lifelong Learning Programme of the European Union is the result of intense collaboration among four institutions, teaching applied sciences and technology. It aims to apply the principles and possibilities of evolved distance and…

Designing Educational Games for Computer Programming: A Holistic Framework

ERIC Educational Resources Information Center

Malliarakis, Christos; Satratzemi, Maya; Xinogalos, Stelios

2014-01-01

Computer science is continuously evolving during the past decades. This has also brought forth new knowledge that should be incorporated and new learning strategies must be adopted for the successful teaching of all sub-domains. For example, computer programming is a vital knowledge area within computer science with constantly changing curriculum…

New Literacy Implementation: The Impact of Professional Development on Middle School Student Science Learning

ERIC Educational Resources Information Center

Hsu, Hui-Yin; Wang, Shaing-Kwei; Coster, Daniel

2017-01-01

With advancing technology, "literacy" evolves to include new forms of literacy made possible by digital technologies. "New literacy" refers to using technology to research, locate, evaluate, synthesize and communication information. The purpose of the study is to develop a framework to guide science teachers' new literacy…

Merchandising's Evolving Role in Family and Consumer Sciences

ERIC Educational Resources Information Center

Sullivan, Pauline; Collier, Billie J.; Goldsmith, Elizabeth B.

2011-01-01

Merchandising and consumer economics traditionally have been part of family and consumer sciences (FCS) within the ecosystems framework. The purpose of this article is to examine progress of this sub-system within FCS. Specifically, the authors explore the relevance of the systems approach for merchandising programs and conclude that this model is…

Catalyzing curriculum evolution in graduate science education.

PubMed

Gutlerner, Johanna L; Van Vactor, David

2013-05-09

Strategies in life science graduate education must evolve in order to train a modern workforce capable of integrative solutions to challenging problems. Our institution has catalyzed such evolution through building a postdoctoral Curriculum Fellows Program that provides a collaborative and scholarly education laboratory for innovation in graduate training. Copyright © 2013 Elsevier Inc. All rights reserved.

A Microcosm of the Biomedical Research Experience for Upper-Level Undergraduates

ERIC Educational Resources Information Center

Hurd, Daryl D.

2008-01-01

The skill set required of biomedical researchers continues to grow and evolve as biology matures as a natural science. Science necessitates creative yet critical thinking, persuasive communication skills, purposeful use of time, and adeptness at the laboratory bench. Teaching these skills can be effectively accomplished in an inquiry-based,…

Educational Impact of Digital Visualization Tools on Digital Character Production Computer Science Courses

ERIC Educational Resources Information Center

van Langeveld, Mark Christensen

2009-01-01

Digital character production courses have traditionally been taught in art departments. The digital character production course at the University of Utah is centered, drawing uniformly from art and engineering disciplines. Its design has evolved to include a synergy of computer science, functional art and human anatomy. It gives students an…

Primary Science Education in China

ERIC Educational Resources Information Center

Pook, Gayle

2013-01-01

Consider the extent to which primary science teaching has evolved since it became a core subject in England with the introduction of the National Curriculum in 1988, and the pace at which theory-driven classroom practice has advanced. It is no wonder that, given the recent economic restructuring and boom in technological development in China,…

Using Program Theory-Driven Evaluation Science to Crack the Da Vinci Code

ERIC Educational Resources Information Center

Donaldson, Stewart I.

2005-01-01

Program theory-driven evaluation science uses substantive knowledge, as opposed to method proclivities, to guide program evaluations. It aspires to update, clarify, simplify, and make more accessible the evolving theory of evaluation practice commonly referred to as theory-driven or theory-based evaluation. The evaluator in this chapter provides a…

Evolving Impressions: Undergraduate Perceptions of Graduate Teaching Assistants and Faculty Members over a Semester

ERIC Educational Resources Information Center

Kendall, K. Denise; Schussler, Elisabeth E.

2013-01-01

Undergraduate experiences in lower-division science courses are important factors in student retention in science majors. These courses often include a lecture taught by faculty, supplemented by smaller sections, such as discussions and laboratories, taught by graduate teaching assistants (GTAs). Given that portions of these courses are taught by…

Socio-Scientific Issues in Health Contexts: Treading a Rugged Terrain

ERIC Educational Resources Information Center

Lee, Yeung Chung

2012-01-01

The science-technology-society agenda has evolved over time to meet emerging educational aims in the light of changes in society and the environment. There is increasing emphasis on students' decision-making on socio-scientific issues (SSIs) not only to highlight the intricate relationships between science, technology, society, and the…

Mutable Mobiles: Online Journals and the Evolving Genre Ecosystem of Science

ERIC Educational Resources Information Center

Casper, Christian Fredrick

2009-01-01

This dissertation addresses the related questions of how online communication technologies affect communication in science and, more broadly, how new ways of interaction in online spaces affect how texts enact genres. Genres have been usefully thought of as typified discursive responses to recurrent social exigences, and much recent work has shown…

Uniformity and Diversity in an Evolving University Federation

ERIC Educational Resources Information Center

Pratt, John

2013-01-01

In 2008, three universities of applied sciences in the Helsinki metropolitan area of Finland signed a partnership agreement to form the Federation of Universities of Applied Sciences (FUAS). In 2011 FUAS invited a small team of international experts to undertake a curriculum review of a sample of its programmes. This article reports some of the…

Facts or friction: the evolving role of science in phytosanitary issues

Treesearch

Eric Allen

2008-01-01

With the expansion of global trade, problems with invasive alien pests have also grown. In order to reduce the international movement of plant pests and protect valuable plant resources, national plant protection regulations and international standards continue to be developed. Science is critical to the development of effective national and international plant...

How College Science Students Engage in Note-Taking Strategies

ERIC Educational Resources Information Center

Bonner, Janice M.; Holliday, William G.

2006-01-01

A composite theory of college science student note-taking strategies was derived from a periodic series of five interviews with 23 students and with other variables, including original and final versions of notes analyzed during a semester-long genetics course. This evolving composite theory was later compared with Van Meter, Yokoi, and Pressley's…

Unidata's Vision for Transforming Geoscience by Moving Data Services and Software to the Cloud

NASA Astrophysics Data System (ADS)

Ramamurthy, M. K.; Fisher, W.; Yoksas, T.

2014-12-01

Universities are facing many challenges: shrinking budgets, rapidly evolving information technologies, exploding data volumes, multidisciplinary science requirements, and high student expectations. These changes are upending traditional approaches to accessing and using data and software. It is clear that Unidata's products and services must evolve to support new approaches to research and education. After years of hype and ambiguity, cloud computing is maturing in usability in many areas of science and education, bringing the benefits of virtualized and elastic remote services to infrastructure, software, computation, and data. Cloud environments reduce the amount of time and money spent to procure, install, and maintain new hardware and software, and reduce costs through resource pooling and shared infrastructure. Cloud services aimed at providing any resource, at any time, from any place, using any device are increasingly being embraced by all types of organizations. Given this trend and the enormous potential of cloud-based services, Unidata is taking moving to augment its products, services, data delivery mechanisms and applications to align with the cloud-computing paradigm. Specifically, Unidata is working toward establishing a community-based development environment that supports the creation and use of software services to build end-to-end data workflows. The design encourages the creation of services that can be broken into small, independent chunks that provide simple capabilities. Chunks could be used individually to perform a task, or chained into simple or elaborate workflows. The services will also be portable, allowing their use in researchers' own cloud-based computing environments. In this talk, we present a vision for Unidata's future in a cloud-enabled data services and discuss our initial efforts to deploy a subset of Unidata data services and tools in the Amazon EC2 and Microsoft Azure cloud environments, including the transfer of real-time meteorological data into its cloud instances, product generation using those data, and the deployment of TDS, McIDAS ADDE and AWIPS II data servers and the Integrated Data Server visualization tool.

Changing and Evolving Relationships between Two- and Four-Year Colleges and Universities: They're Not Your Parents' Community Colleges Anymore

ERIC Educational Resources Information Center

Labov, Jay B.

2012-01-01

This paper describes a summit on Community Colleges in the Evolving STEM Education Landscape organized by a committee of the National Research Council (NRC) and the National Academy of Engineering (NAE) and held at the Carnegie Institution for Science on December 15, 2011. This summit followed a similar event organized by Dr. Jill Biden, spouse of…

Thermal and Evolved Gas Analysis of Calcite Under Reduced Operating Pressures: Implications for the 2011 MSL Sample Analysis at Mars (SAM) Instrument

NASA Technical Reports Server (NTRS)

Lauer, H. V. Jr.; Ming, D. W.; Sutter, B.; Mahaffy, P. R.

2010-01-01

The Mars Science Laboratory (MSL) is scheduled for launch in 2011. The science objectives for MSL are to assess the past or present biological potential, to characterize the geology, and to investigate other planetary processes that influence habitability at the landing site. The Sample Analysis at Mars (SAM) is a key instrument on the MSL payload that will explore the potential habitability at the landing site [1]. In addition to searching for organic compounds, SAM will have the capability to characterized evolved gases as a function of increasing temperature and provide information on the mineralogy of volatile-bearing phases such as carbonates, sulfates, phyllosilicates, and Fe-oxyhydroxides. The operating conditions in SAM ovens will be maintained at 30 mb pressure with a He carrier gas flowing at 1 sccm. We have previously characterized the thermal and evolved gas behaviors of volatile-bearing species under reduced pressure conditions that simulated operating conditions of the Thermal and Evolved Gas Analyzer (TEGA) that was onboard the 2007 Mars Phoenix Scout Mission [e.g., 2-8]. TEGA ovens operated at 12 mb pressure with a N2 carrier gas flowing at 0.04 sccm. Another key difference between SAM and TEGA is that TEGA was able to perform differential scanning calorimetry whereas SAM only has a pyrolysis oven. The operating conditions for TEGA and SAM have several key parameter differences including operating pressure (12 vs 30 mb), carrier gas (N2 vs. He), and carrier gas flow rate (0.04 vs 1 sccm). The objectives of this study are to characterize the thermal and evolved gas analysis of calcite under SAM operating conditions and then compare it to calcite thermal and evolved gas analysis under TEGA operating conditions.

The evolution of popular music: USA 1960-2010.

PubMed

Mauch, Matthias; MacCallum, Robert M; Levy, Mark; Leroi, Armand M

2015-05-01

In modern societies, cultural change seems ceaseless. The flux of fashion is especially obvious for popular music. While much has been written about the origin and evolution of pop, most claims about its history are anecdotal rather than scientific in nature. To rectify this, we investigate the US Billboard Hot 100 between 1960 and 2010. Using music information retrieval and text-mining tools, we analyse the musical properties of approximately 17 000 recordings that appeared in the charts and demonstrate quantitative trends in their harmonic and timbral properties. We then use these properties to produce an audio-based classification of musical styles and study the evolution of musical diversity and disparity, testing, and rejecting, several classical theories of cultural change. Finally, we investigate whether pop musical evolution has been gradual or punctuated. We show that, although pop music has evolved continuously, it did so with particular rapidity during three stylistic 'revolutions' around 1964, 1983 and 1991. We conclude by discussing how our study points the way to a quantitative science of cultural change.

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories.

PubMed

McGibbon, Robert T; Beauchamp, Kyle A; Harrigan, Matthew P; Klein, Christoph; Swails, Jason M; Hernández, Carlos X; Schwantes, Christian R; Wang, Lee-Ping; Lane, Thomas J; Pande, Vijay S

2015-10-20

As molecular dynamics (MD) simulations continue to evolve into powerful computational tools for studying complex biomolecular systems, the necessity of flexible and easy-to-use software tools for the analysis of these simulations is growing. We have developed MDTraj, a modern, lightweight, and fast software package for analyzing MD simulations. MDTraj reads and writes trajectory data in a wide variety of commonly used formats. It provides a large number of trajectory analysis capabilities including minimal root-mean-square-deviation calculations, secondary structure assignment, and the extraction of common order parameters. The package has a strong focus on interoperability with the wider scientific Python ecosystem, bridging the gap between MD data and the rapidly growing collection of industry-standard statistical analysis and visualization tools in Python. MDTraj is a powerful and user-friendly software package that simplifies the analysis of MD data and connects these datasets with the modern interactive data science software ecosystem in Python. Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All rights reserved.

PYCHEM: a multivariate analysis package for python.

PubMed

Jarvis, Roger M; Broadhurst, David; Johnson, Helen; O'Boyle, Noel M; Goodacre, Royston

2006-10-15

We have implemented a multivariate statistical analysis toolbox, with an optional standalone graphical user interface (GUI), using the Python scripting language. This is a free and open source project that addresses the need for a multivariate analysis toolbox in Python. Although the functionality provided does not cover the full range of multivariate tools that are available, it has a broad complement of methods that are widely used in the biological sciences. In contrast to tools like MATLAB, PyChem 2.0.0 is easily accessible and free, allows for rapid extension using a range of Python modules and is part of the growing amount of complementary and interoperable scientific software in Python based upon SciPy. One of the attractions of PyChem is that it is an open source project and so there is an opportunity, through collaboration, to increase the scope of the software and to continually evolve a user-friendly platform that has applicability across a wide range of analytical and post-genomic disciplines. http://sourceforge.net/projects/pychem

Studying seafloor bedforms using autonomous stationary imaging and profiling sonars

USGS Publications Warehouse

Montgomery, Ellyn T.; Sherwood, Christopher R.

2014-01-01

The Sediment Transport Group at the U.S. Geological Survey, Woods Hole Coastal and Marine Science Center uses downward looking sonars deployed on seafloor tripods to assess and measure the formation and migration of bedforms. The sonars have been used in three resolution-testing experiments, and deployed autonomously to observe changes in the seafloor for up to two months in seven field experiments since 2002. The sonar data are recorded concurrently with measurements of waves and currents to: a) relate bedform geometry to sediment and flow characteristics; b) assess hydrodynamic drag caused by bedforms; and c) estimate bedform sediment transport rates, all with the goal of evaluating and improving numerical models of these processes. Our hardware, data processing methods, and test and validation procedures have evolved since 2001. We now employ a standard sonar configuration that provides reliable data for correlating flow conditions with bedform morphology. Plans for the future are to sample more rapidly and improve the precision of our tripod orientation measurements.

The Changing Science of Urban Transportation Planning

NASA Astrophysics Data System (ADS)

Kloster, Tom

2010-03-01

The last half of the 20th Century was the age of the automobile, and the development of bigger and faster roads defined urban planning for more than 50 years. During this period, transportation planners developed sophisticated behavior models to help predict future travel patterns in an attempt to keep pace with ever-growing congestion and public demand for more roads. By the 1990s, however, it was clear that eliminating congestion with new road capacity was an unattainable outcome, and had unintended effects that were never considered when the automobile era first emerged. Today, public expectations are rapidly evolving beyond ``building our way out'' of congestion, and toward more complex definitions of desired outcomes in transportation planning. In this new century, planners must improve behavior models to predict not only the travel patterns of the future, but also the subsequent environmental, social and public health effects associated with growth and changes in travel behavior, and provide alternative transportation solutions that respond to these broader outcomes.

New Perspectives Regarding Anaplastic Thyroid Carcinoma Approach Improvement.

PubMed

Figueiredo, Ana Sofia; Andrea-Ferreira, Patricia

2018-06-10

Anaplastic thyroid carcinoma is rare, but represents the deadliest type of thyroid cancer that is characterised by a rapid course. Diagnosis is usually made at a late stage, when more than half of the patients have distant metastasis. Our main purpose is to review the current information on anaplastic thyroid aetiology and risk factors that might contribute to an earlier diagnosis as well as to give new perspectives regarding the most recent treatment options and future directions. The treatment options are mainly palliative and lack efficacy. In particular, the multikinase inhibitors, BRAF inhibitors and other directed agents aim to stabilize the tumour growth and might enable a radical surgery with curative intent. With the mutational landscape investigation and the discovery of new targets, new directed treatments are being tried. Considering the current tendency to be more conservative regarding the multinodular goitre approach and some differentiated thyroid carcinomas treatment, it is vital to understand that it might evolve to anaplastic cancers. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Multidisciplinary approaches to stimulate wound healing.

PubMed

Businaro, Rita; Corsi, Mariangela; Di Raimo, Tania; Marasco, Sergio; Laskin, Debra L; Salvati, Bruno; Capoano, Raffaele; Ricci, Serafino; Siciliano, Camilla; Frati, Giacomo; De Falco, Elena

2016-08-01

New civil wars and waves of terrorism are causing crucial social changes, with consequences in all fields, including health care. In particular, skin injuries are evolving as an epidemic issue. From a physiological standpoint, although wound repair takes place more rapidly in the skin than in other tissues, it is still a complex organ to reconstruct. Genetic and clinical variables, such as diabetes, smoking, and inflammatory/immunological pathologies, are also important risk factors limiting the regenerative potential of many therapeutic applications. Therefore, optimization of current clinical strategies is critical. Here, we summarize the current state of the field by focusing on stem cell therapy applications in wound healing, with an emphasis on current clinical approaches being developed. These involve protocols for the ex vivo expansion of adipose tissue-derived mesenchymal stem cells by means of a patented Good Manufacturing Practice-compliant platelet lysate. Combinations of multiple strategies, including genetic modifications and stem cells, biomimetic scaffolds, and novel vehicles, such as nanoparticles, are also discussed as future approaches. © 2016 New York Academy of Sciences.

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

PubMed Central

McGibbon, Robert T.; Beauchamp, Kyle A.; Harrigan, Matthew P.; Klein, Christoph; Swails, Jason M.; Hernández, Carlos X.; Schwantes, Christian R.; Wang, Lee-Ping; Lane, Thomas J.; Pande, Vijay S.

2015-01-01

As molecular dynamics (MD) simulations continue to evolve into powerful computational tools for studying complex biomolecular systems, the necessity of flexible and easy-to-use software tools for the analysis of these simulations is growing. We have developed MDTraj, a modern, lightweight, and fast software package for analyzing MD simulations. MDTraj reads and writes trajectory data in a wide variety of commonly used formats. It provides a large number of trajectory analysis capabilities including minimal root-mean-square-deviation calculations, secondary structure assignment, and the extraction of common order parameters. The package has a strong focus on interoperability with the wider scientific Python ecosystem, bridging the gap between MD data and the rapidly growing collection of industry-standard statistical analysis and visualization tools in Python. MDTraj is a powerful and user-friendly software package that simplifies the analysis of MD data and connects these datasets with the modern interactive data science software ecosystem in Python. PMID:26488642

Optimal nutrition and the ever-changing dietary landscape: a conference report.

PubMed

Shao, A; Drewnowski, A; Willcox, D C; Krämer, L; Lausted, C; Eggersdorfer, M; Mathers, J; Bell, J D; Randolph, R K; Witkamp, R; Griffiths, J C

2017-05-01

The field of nutrition has evolved rapidly over the past century. Nutrition scientists and policy makers in the developed world have shifted the focus of their efforts from dealing with diseases of overt nutrient deficiency to a new paradigm aimed at coping with conditions of excess-calories, sedentary lifestyles and stress. Advances in nutrition science, technology and manufacturing have largely eradicated nutrient deficiency diseases, while simultaneously facing the growing challenges of obesity, non-communicable diseases and aging. Nutrition research has gone through a necessary evolution, starting with a reductionist approach, driven by an ambition to understand the mechanisms responsible for the effects of individual nutrients at the cellular and molecular levels. This approach has appropriately expanded in recent years to become more holistic with the aim of understanding the role of nutrition in the broader context of dietary patterns. Ultimately, this approach will culminate in a full understanding of the dietary landscape-a web of interactions between nutritional, dietary, social, behavioral and environmental factors-and how it impacts health maintenance and promotion.

Whole-genome analyses resolve early branches in the tree of life of modern birds.

PubMed

Jarvis, Erich D; Mirarab, Siavash; Aberer, Andre J; Li, Bo; Houde, Peter; Li, Cai; Ho, Simon Y W; Faircloth, Brant C; Nabholz, Benoit; Howard, Jason T; Suh, Alexander; Weber, Claudia C; da Fonseca, Rute R; Li, Jianwen; Zhang, Fang; Li, Hui; Zhou, Long; Narula, Nitish; Liu, Liang; Ganapathy, Ganesh; Boussau, Bastien; Bayzid, Md Shamsuzzoha; Zavidovych, Volodymyr; Subramanian, Sankar; Gabaldón, Toni; Capella-Gutiérrez, Salvador; Huerta-Cepas, Jaime; Rekepalli, Bhanu; Munch, Kasper; Schierup, Mikkel; Lindow, Bent; Warren, Wesley C; Ray, David; Green, Richard E; Bruford, Michael W; Zhan, Xiangjiang; Dixon, Andrew; Li, Shengbin; Li, Ning; Huang, Yinhua; Derryberry, Elizabeth P; Bertelsen, Mads Frost; Sheldon, Frederick H; Brumfield, Robb T; Mello, Claudio V; Lovell, Peter V; Wirthlin, Morgan; Schneider, Maria Paula Cruz; Prosdocimi, Francisco; Samaniego, José Alfredo; Vargas Velazquez, Amhed Missael; Alfaro-Núñez, Alonzo; Campos, Paula F; Petersen, Bent; Sicheritz-Ponten, Thomas; Pas, An; Bailey, Tom; Scofield, Paul; Bunce, Michael; Lambert, David M; Zhou, Qi; Perelman, Polina; Driskell, Amy C; Shapiro, Beth; Xiong, Zijun; Zeng, Yongli; Liu, Shiping; Li, Zhenyu; Liu, Binghang; Wu, Kui; Xiao, Jin; Yinqi, Xiong; Zheng, Qiuemei; Zhang, Yong; Yang, Huanming; Wang, Jian; Smeds, Linnea; Rheindt, Frank E; Braun, Michael; Fjeldsa, Jon; Orlando, Ludovic; Barker, F Keith; Jønsson, Knud Andreas; Johnson, Warren; Koepfli, Klaus-Peter; O'Brien, Stephen; Haussler, David; Ryder, Oliver A; Rahbek, Carsten; Willerslev, Eske; Graves, Gary R; Glenn, Travis C; McCormack, John; Burt, Dave; Ellegren, Hans; Alström, Per; Edwards, Scott V; Stamatakis, Alexandros; Mindell, David P; Cracraft, Joel; Braun, Edward L; Warnow, Tandy; Jun, Wang; Gilbert, M Thomas P; Zhang, Guojie

2014-12-12

To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergence in Neoaves, two groups we named Passerea and Columbea, representing independent lineages of diverse and convergently evolved land and water bird species. Among Passerea, we infer the common ancestor of core landbirds to have been an apex predator and confirm independent gains of vocal learning. Among Columbea, we identify pigeons and flamingoes as belonging to sister clades. Even with whole genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein-coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous-Paleogene mass extinction event about 66 million years ago. Copyright © 2014, American Association for the Advancement of Science.

Healthy family functioning: a cross-cultural appraisal*

PubMed Central

David, Henry P.

1978-01-01

It is increasingly recognized that rapid cultural, social, economic, and technological changes are imposing increasing stress on family structures, traditional values, and the ability to adapt to new environments in different societies. For the purposes of this paper, ”healthy family functioning” is defined in terms of a family unit (however it is conceived in any given culture) effectively coping with cultural, environmental, psychosocial, and socioeconomic stresses throughout the family life cycle. While a review of international literature in the behavioural and biomedical sciences yields little data on comparative studies, there is growing awareness of the need for cooperative international research on family coping mechanisms and determinants of self-reliant communal coping behaviour, as well as more efficient utilization of already available knowledge. After consideration of methodological pitfalls of assessment procedures, there is a presentation of an evolving theory of healthy family functioning with the suggestion that studies of young married couples constitute a particularly promising vehicle for developing needed cooperative cross-cultural research. PMID:308401

Global link between deformation and volcanic eruption quantified by satellite imagery

PubMed Central

Biggs, J.; Ebmeier, S. K.; Aspinall, W. P.; Lu, Z.; Pritchard, M. E.; Sparks, R. S. J.; Mather, T. A.

2014-01-01

A key challenge for volcanological science and hazard management is that few of the world’s volcanoes are effectively monitored. Satellite imagery covers volcanoes globally throughout their eruptive cycles, independent of ground-based monitoring, providing a multidecadal archive suitable for probabilistic analysis linking deformation with eruption. Here we show that, of the 198 volcanoes systematically observed for the past 18 years, 54 deformed, of which 25 also erupted. For assessing eruption potential, this high proportion of deforming volcanoes that also erupted (46%), together with the proportion of non-deforming volcanoes that did not erupt (94%), jointly represent indicators with ‘strong’ evidential worth. Using a larger catalogue of 540 volcanoes observed for 3 years, we demonstrate how this eruption–deformation relationship is influenced by tectonic, petrological and volcanic factors. Satellite technology is rapidly evolving and routine monitoring of the deformation status of all volcanoes from space is anticipated, meaning probabilistic approaches will increasingly inform hazard decisions and strategic development. PMID:24699342

The prevalence of mind-body dualism in early China.

PubMed

Slingerland, Edward; Chudek, Maciej

2011-07-01

We present the first large-scale, quantitative examination of mind and body concepts in a set of historical sources by measuring the predictions of folk mind-body dualism against the surviving textual corpus of pre-Qin (pre-221 BCE) China. Our textual analysis found clear patterns in the historically evolving reference of the word xin (heart/heart-mind): It alone of the organs was regularly contrasted with the physical body, and during the Warring States period it became less associated with emotions and increasingly portrayed as the unique locus of "higher" cognitive abilities. We interpret this as a semantic shift toward a shared cognitive bias in response to a vast and rapid expansion of literacy. Our study helps test the proposed universality of folk dualism, adds a new quantitative approach to the methods used in the humanities, and opens up a new and valuable data source for cognitive scientists: the record of dead minds. Copyright © 2011 Cognitive Science Society, Inc.

Early spectra of the gravitational wave source GW170817: Evolution of a neutron star merger.

PubMed

Shappee, B J; Simon, J D; Drout, M R; Piro, A L; Morrell, N; Prieto, J L; Kasen, D; Holoien, T W-S; Kollmeier, J A; Kelson, D D; Coulter, D A; Foley, R J; Kilpatrick, C D; Siebert, M R; Madore, B F; Murguia-Berthier, A; Pan, Y-C; Prochaska, J X; Ramirez-Ruiz, E; Rest, A; Adams, C; Alatalo, K; Bañados, E; Baughman, J; Bernstein, R A; Bitsakis, T; Boutsia, K; Bravo, J R; Di Mille, F; Higgs, C R; Ji, A P; Maravelias, G; Marshall, J L; Placco, V M; Prieto, G; Wan, Z

2017-12-22

On 17 August 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neutron star gravitational wave event GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until 8.5 days after the merger. Over the first hour of observations, the ejecta rapidly expanded and cooled. Applying blackbody fits to the spectra, we measured the photosphere cooling from [Formula: see text] to [Formula: see text] kelvin, and determined a photospheric velocity of roughly 30% of the speed of light. The spectra of SSS17a began displaying broad features after 1.46 days and evolved qualitatively over each subsequent day, with distinct blue (early-time) and red (late-time) components. The late-time component is consistent with theoretical models of r-process-enriched neutron star ejecta, whereas the blue component requires high-velocity, lanthanide-free material. Copyright © 2017, American Association for the Advancement of Science.

NASA Centers and Universities Collaborate Through Smallsat Technology Partnerships

NASA Technical Reports Server (NTRS)

Cockrell, James

2018-01-01

The Small Spacecraft Technology (SST) Program within the NASA Space Technology Mission Directorate is chartered develop and demonstrate the capabilities that enable small spacecraft to achieve science and exploration missions in "unique" and "more affordable" ways. Specifically, the SST program seeks to enable new mission architectures through the use of small spacecraft, to expand the reach of small spacecraft to new destinations, and to make possible the augmentation existing assets and future missions with supporting small spacecraft. The SST program sponsors smallsat technology development partnerships between universities and NASA Centers in order to engage the unique talents and fresh perspectives of the university community and to share NASA experience and expertise in relevant university projects to develop new technologies and capabilities for small spacecraft. These partnerships also engage NASA personnel in the rapid, agile and cost-conscious small spacecraft approaches that have evolved in the university community, as well as increase support to university efforts and foster a new generation of innovators for NASA and the nation.

Re-presentations of space in Hollywood movies: an event-indexing analysis.

PubMed

Cutting, James; Iricinschi, Catalina

2015-03-01

Popular movies present chunk-like events (scenes and subscenes) that promote episodic, serial updating of viewers' representations of the ongoing narrative. Event-indexing theory would suggest that the beginnings of new scenes trigger these updates, which in turn require more cognitive processing. Typically, a new movie event is signaled by an establishing shot, one providing more background information and a longer look than the average shot. Our analysis of 24 films reconfirms this. More important, we show that, when returning to a previously shown location, the re-establishing shot reduces both context and duration while remaining greater than the average shot. In general, location shifts dominate character and time shifts in event segmentation of movies. In addition, over the last 70 years re-establishing shots have become more like the noninitial shots of a scene. Establishing shots have also approached noninitial shot scales, but not their durations. Such results suggest that film form is evolving, perhaps to suit more rapid encoding of narrative events. Copyright © 2014 Cognitive Science Society, Inc.

Global link between deformation and volcanic eruption quantified by satellite imagery.

PubMed

Biggs, J; Ebmeier, S K; Aspinall, W P; Lu, Z; Pritchard, M E; Sparks, R S J; Mather, T A

2014-04-03

A key challenge for volcanological science and hazard management is that few of the world's volcanoes are effectively monitored. Satellite imagery covers volcanoes globally throughout their eruptive cycles, independent of ground-based monitoring, providing a multidecadal archive suitable for probabilistic analysis linking deformation with eruption. Here we show that, of the 198 volcanoes systematically observed for the past 18 years, 54 deformed, of which 25 also erupted. For assessing eruption potential, this high proportion of deforming volcanoes that also erupted (46%), together with the proportion of non-deforming volcanoes that did not erupt (94%), jointly represent indicators with 'strong' evidential worth. Using a larger catalogue of 540 volcanoes observed for 3 years, we demonstrate how this eruption-deformation relationship is influenced by tectonic, petrological and volcanic factors. Satellite technology is rapidly evolving and routine monitoring of the deformation status of all volcanoes from space is anticipated, meaning probabilistic approaches will increasingly inform hazard decisions and strategic development.

HIV-TRACE (Transmission Cluster Engine): a tool for large scale molecular epidemiology of HIV-1 and other rapidly evolving pathogens.

PubMed

Kosakovsky Pond, Sergei L; Weaver, Steven; Leigh Brown, Andrew J; Wertheim, Joel O

2018-01-31

In modern applications of molecular epidemiology, genetic sequence data are routinely used to identify clusters of transmission in rapidly evolving pathogens, most notably HIV-1. Traditional 'shoeleather' epidemiology infers transmission clusters by tracing chains of partners sharing epidemiological connections (e.g., sexual contact). Here, we present a computational tool for identifying a molecular transmission analog of such clusters: HIV-TRACE (TRAnsmission Cluster Engine). HIV-TRACE implements an approach inspired by traditional epidemiology, by identifying chains of partners whose viral genetic relatedness imply direct or indirect epidemiological connections. Molecular transmission clusters are constructed using codon-aware pairwise alignment to a reference sequence followed by pairwise genetic distance estimation among all sequences. This approach is computationally tractable and is capable of identifying HIV-1 transmission clusters in large surveillance databases comprising tens or hundreds of thousands of sequences in near real time, i.e., on the order of minutes to hours. HIV-TRACE is available at www.hivtrace.org and from github.com/veg/hivtrace, along with the accompanying result visualization module from github.com/veg/hivtrace-viz. Importantly, the approach underlying HIV-TRACE is not limited to the study of HIV-1 and can be applied to study outbreaks and epidemics of other rapidly evolving pathogens. © The Author 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A Web 2.0 and OGC Standards Enabled Sensor Web Architecture for Global Earth Observing System of Systems

NASA Technical Reports Server (NTRS)

Mandl, Daniel; Unger, Stephen; Ames, Troy; Frye, Stuart; Chien, Steve; Cappelaere, Pat; Tran, Danny; Derezinski, Linda; Paules, Granville

2007-01-01

This paper will describe the progress of a 3 year research award from the NASA Earth Science Technology Office (ESTO) that began October 1, 2006, in response to a NASA Announcement of Research Opportunity on the topic of sensor webs. The key goal of this research is to prototype an interoperable sensor architecture that will enable interoperability between a heterogeneous set of space-based, Unmanned Aerial System (UAS)-based and ground based sensors. Among the key capabilities being pursued is the ability to automatically discover and task the sensors via the Internet and to automatically discover and assemble the necessary science processing algorithms into workflows in order to transform the sensor data into valuable science products. Our first set of sensor web demonstrations will prototype science products useful in managing wildfires and will use such assets as the Earth Observing 1 spacecraft, managed out of NASA/GSFC, a UASbased instrument, managed out of Ames and some automated ground weather stations, managed by the Forest Service. Also, we are collaborating with some of the other ESTO awardees to expand this demonstration and create synergy between our research efforts. Finally, we are making use of Open Geospatial Consortium (OGC) Sensor Web Enablement (SWE) suite of standards and some Web 2.0 capabilities to Beverage emerging technologies and standards. This research will demonstrate and validate a path for rapid, low cost sensor integration, which is not tied to a particular system, and thus be able to absorb new assets in an easily evolvable, coordinated manner. This in turn will help to facilitate the United States contribution to the Global Earth Observation System of Systems (GEOSS), as agreed by the U.S. and 60 other countries at the third Earth Observation Summit held in February of 2005.

Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT).

PubMed

de Matas, Marcel; De Beer, Thomas; Folestad, Staffan; Ketolainen, Jarkko; Lindén, Hans; Lopes, João Almeida; Oostra, Wim; Weimer, Marco; Öhrngren, Per; Rantanen, Jukka

2016-07-30

The regulatory and technical landscape of the pharmaceutical field is rapidly evolving from one focused predominantly on development of small molecules, using well established manufacturing technologies towards an environment in which biologicals and complex modalities are being developed using advanced science and technology coupled with the application of modern Quality by Design (QbD) principles. In order that Europe keeps pace with these changes and sustains its position as major player in the development and commercialization of medicines, it is essential that measures are put in place to maintain a highly skilled workforce. A number of challenges however exist to equipping academic, industrial and health agency staff with the requisite knowledge, skills and experience to develop the next generation of medicines. In this regard, the EUFEPS QbD and PAT Sciences Network has proposed a structured framework for education, training and continued professional development, which comprises a number of pillars covering the fundamental principles of modern pharmaceutical development including the underpinning aspects of science, engineering and technology innovation. The framework is not prescriptive and is not aimed at describing specific course content in detail. It should however be used as a point of reference for those institutions delivering pharmaceutical based educational courses, to ensure that the necessary skills, knowledge and experience for successful pharmaceutical development are maintained. A positive start has been made and a number of examples of formal higher education courses and short training programs containing elements of this framework have been described. The ultimate vision for this framework however, is to see widespread adoption and proliferation of this curriculum with it forming the backbone of QbD and PAT science based skills development. Copyright © 2016 Elsevier B.V. All rights reserved.

Rapid evolution of troglomorphic characters suggests selection rather than neutral mutation as a driver of eye reduction in cave crabs.

PubMed

Klaus, Sebastian; Mendoza, José C E; Liew, Jia Huan; Plath, Martin; Meier, Rudolf; Yeo, Darren C J

2013-04-23

This study asked whether reductive traits in cave organisms evolve at a slower pace (suggesting neutral evolution under relaxed selection) than constructive changes, which are likely to evolve under directional selection. We investigated 11 subterranean and seven surface populations of Sundathelphusa freshwater crabs on Bohol Island, Philippines, and examined constructive traits associated with improved food finding in darkness (increased leg and setae length) and reductive traits (reduced cornea size and eyestalk length). All changes occurred rapidly, given that the age of the most recent common ancestor was estimated to be 722-271 ka based on three mitochondrial markers. In order to quantify the speed of character change, we correlated the degree of morphological change with genetic distances between surface and subterranean individuals. The temporal pattern of character change following the transition to subterranean life was indistinguishable for constructive and reductive traits, characterized by an immediate onset and rapid evolutionary change. We propose that the evolution of these reductive traits-just like constructive traits-is most likely driven by strong directional selection.

A mental model of science informed by public lands managers: Increasing the chances for management based on science

Treesearch

Alan E. Watson; Christopher A. Armatas

2017-01-01

Some federal public lands have been legally protected as “wilderness areas” since 1964 in the US. A federal science program evolved first in response to a novel public lands management concept, and subsequently in response to new issues that emerged both as society changed and more knowledge about social and ecological values of wilderness accumulated. Wilderness...

Evolved Gas Analyses of Sedimentary Materials in Gale Crater, Mars: Results of the Curiosity Rover's Sample Analysis at Mars (SAM) Instrument from Yellowknife Bay to the Stimson Formation

NASA Technical Reports Server (NTRS)

Sutter, B.; McAdam, A. C.; Rampe, E. B.; Ming, D. W.; Mahaffy, P. R.; Navarro-Gonzalez, R.; Stern, J. C.; Eigenbrode, J. L.; Archer, P. D.

2016-01-01

The Sample Analysis at Mars (SAM) instrument aboard the Mars Science Laboratory rover has analyzed 10 samples from Gale Crater. All SAM evolved gas analyses have yielded a multitude of volatiles (e.g, H2O, SO2, H2S, CO2, CO, NO, O2, HC1). The objectives of this work are to 1) Characterize the evolved H2O, SO2, CO2, and O2 gas traces of sediments analyzed by SAM through sol 1178, 2) Constrain sediment mineralogy/composition based on SAM evolved gas analysis (SAM-EGA), and 3) Discuss the implications of these results releative to understanding the geochemical history of Gale Crater.

More rapid climate change promotes evolutionary rescue through selection for increased dispersal distance

PubMed Central

Boeye, Jeroen; Travis, Justin M J; Stoks, Robby; Bonte, Dries

2013-01-01

Species can either adapt to new conditions induced by climate change or shift their range in an attempt to track optimal environmental conditions. During current range shifts, species are simultaneously confronted with a second major anthropogenic disturbance, landscape fragmentation. Using individual-based models with a shifting climate window, we examine the effect of different rates of climate change on the evolution of dispersal distances through changes in the genetically determined dispersal kernel. Our results demonstrate that the rate of climate change is positively correlated to the evolved dispersal distances although too fast climate change causes the population to crash. When faced with realistic rates of climate change, greater dispersal distances evolve than those required for the population to keep track of the climate, thereby maximizing population size. Importantly, the greater dispersal distances that evolve when climate change is more rapid, induce evolutionary rescue by facilitating the population in crossing large gaps in the landscape. This could ensure population persistence in case of range shifting in fragmented landscapes. Furthermore, we highlight problems in using invasion speed as a proxy for potential range shifting abilities under climate change. PMID:23467649

Assessing Multivariate Constraints to Evolution across Ten Long-Term Avian Studies

PubMed Central

Teplitsky, Celine; Tarka, Maja; Møller, Anders P.; Nakagawa, Shinichi; Balbontín, Javier; Burke, Terry A.; Doutrelant, Claire; Gregoire, Arnaud; Hansson, Bengt; Hasselquist, Dennis; Gustafsson, Lars; de Lope, Florentino; Marzal, Alfonso; Mills, James A.; Wheelwright, Nathaniel T.; Yarrall, John W.; Charmantier, Anne

2014-01-01

Background In a rapidly changing world, it is of fundamental importance to understand processes constraining or facilitating adaptation through microevolution. As different traits of an organism covary, genetic correlations are expected to affect evolutionary trajectories. However, only limited empirical data are available. Methodology/Principal Findings We investigate the extent to which multivariate constraints affect the rate of adaptation, focusing on four morphological traits often shown to harbour large amounts of genetic variance and considered to be subject to limited evolutionary constraints. Our data set includes unique long-term data for seven bird species and a total of 10 populations. We estimate population-specific matrices of genetic correlations and multivariate selection coefficients to predict evolutionary responses to selection. Using Bayesian methods that facilitate the propagation of errors in estimates, we compare (1) the rate of adaptation based on predicted response to selection when including genetic correlations with predictions from models where these genetic correlations were set to zero and (2) the multivariate evolvability in the direction of current selection to the average evolvability in random directions of the phenotypic space. We show that genetic correlations on average decrease the predicted rate of adaptation by 28%. Multivariate evolvability in the direction of current selection was systematically lower than average evolvability in random directions of space. These significant reductions in the rate of adaptation and reduced evolvability were due to a general nonalignment of selection and genetic variance, notably orthogonality of directional selection with the size axis along which most (60%) of the genetic variance is found. Conclusions These results suggest that genetic correlations can impose significant constraints on the evolution of avian morphology in wild populations. This could have important impacts on evolutionary dynamics and hence population persistence in the face of rapid environmental change. PMID:24608111

Experimental evolution gone wild.

PubMed

Scheinin, M; Riebesell, U; Rynearson, T A; Lohbeck, K T; Collins, S

2015-05-06

Because of their large population sizes and rapid cell division rates, marine microbes have, or can generate, ample variation to fuel evolution over a few weeks or months, and subsequently have the potential to evolve in response to global change. Here we measure evolution in the marine diatom Skeletonema marinoi evolved in a natural plankton community in CO2-enriched mesocosms deployed in situ. Mesocosm enclosures are typically used to study how the species composition and biogeochemistry of marine communities respond to environmental shifts, but have not been used for experimental evolution to date. Using this approach, we detect a large evolutionary response to CO2 enrichment in a focal marine diatom, where population growth rate increased by 1.3-fold in high CO2-evolved lineages. This study opens an exciting new possibility of carrying out in situ evolution experiments to understand how marine microbial communities evolve in response to environmental change.

Hybridization Reveals the Evolving Genomic Architecture of Speciation

PubMed Central

Kronforst, Marcus R.; Hansen, Matthew E.B.; Crawford, Nicholas G.; Gallant, Jason R.; Zhang, Wei; Kulathinal, Rob J.; Kapan, Durrell D.; Mullen, Sean P.

2014-01-01

SUMMARY The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence evolves during the speciation process. Our analyses reveal that initial divergence is restricted to a small fraction of the genome, largely clustered around known wing-patterning genes. Over time, divergence evolves rapidly, due primarily to the origin of new divergent regions. Furthermore, divergent genomic regions display signatures of both selection and adaptive introgression, demonstrating the link between microevolutionary processes acting within species and the origin of species across macroevolutionary timescales. Our results provide a uniquely comprehensive portrait of the evolving species boundary due to the role that hybridization plays in reducing the background accumulation of divergence at neutral sites. PMID:24183670

Assessing surface albedo change and its induced radiation budget under rapid urbanization with Landsat and GLASS data

NASA Astrophysics Data System (ADS)

Hu, Yonghong; Jia, Gensuo; Pohl, Christine; Zhang, Xiaoxuan; van Genderen, John

2016-02-01

Radiative forcing (RF) induced by land use (mainly surface albedo) change is still not well understood in climate change science, especially the effects of changes in urban albedo due to rapid urbanization on the urban radiation budget. In this study, a modified RF derivation approach based on Landsat images was used to quantify changes in the solar radiation budget induced by variations in surface albedo in Beijing from 2001 to 2009. Field radiation records from a Beijing meteorological station were used to identify changes in RF at the local level. There has been rapid urban expansion over the last decade, with the urban land area increasing at about 3.3 % annually from 2001 to 2009. This has modified three-dimensional urban surface properties, resulting in lower albedo due to complex building configurations of urban centers and higher albedo on flat surfaces of suburban areas and cropland. There was greater solar radiation (6.93 × 108 W) in the urban center in 2009 than in 2001. However, large cropland and urban fringe areas caused less solar radiation absorption. RF increased with distance from the urban center (less than 14 km) and with greater urbanization, with the greatest value being 0.41 W/m2. The solar radiation budget in urban areas was believed to be mainly influenced by urban structural changes in the horizontal and vertical directions. Overall, the results presented herein indicate that cumulative urbanization impacts on the natural radiation budget could evolve into an important driver of local climate change.

NASA science utilization plans for the Space Station.

PubMed

Reeves, E M; Cressy, P J

1995-10-01

The Mir-1 and International Space Station Alpha capabilities present the science community with unique long duration platforms to conduct a wide range of scientific research in the microgravity and life sciences as well as in the observational sciences, NASA is developing plans to use the capabilities of Mir and Space Station as they emerge during the development of the orbital program. In both cases the planned science utilization programs take advantage of the volume, crew, power, microgravity and logistics resupply unique to each phase. The paper will present these utilization plans in the context of an evolving scientific program.

Synthesis of Automated Vehicle Legislation

DOT National Transportation Integrated Search

2017-10-01

This report provides a synthesis of issues addressed by state legislation regarding automated vehicles (AV); AV technologies are rapidly evolving and many states have developed legislation to govern AV testing and deployment and to assure safety on p...

Evolution under changing climates: climatic niche stasis despite rapid evolution in a non-native plant.

PubMed

Alexander, Jake M

2013-09-22

A topic of great current interest is the capacity of populations to adapt genetically to rapidly changing climates, for example by evolving the timing of life-history events, but this is challenging to address experimentally. I use a plant invasion as a model system to tackle this question by combining molecular markers, a common garden experiment and climatic niche modelling. This approach reveals that non-native Lactuca serriola originates primarily from Europe, a climatic subset of its native range, with low rates of admixture from Asia. It has rapidly refilled its climatic niche in the new range, associated with the evolution of flowering phenology to produce clines along climate gradients that mirror those across the native range. Consequently, some non-native plants have evolved development times and grow under climates more extreme than those found in Europe, but not among populations from the native range as a whole. This suggests that many plant populations can adapt rapidly to changed climatic conditions that are already within the climatic niche space occupied by the species elsewhere in its range, but that evolution to conditions outside of this range is more difficult. These findings can also help to explain the prevalence of niche conservatism among non-native species.

Reconstructing the Morphology of an Evolving Coronal Mass Ejection

DTIC Science & Technology

2009-01-01

694, 707 Wood, B. E., Howard, R. A ., Thernisien, A ., Plunkett, S. P., & Socker, D. G. 2009b, Sol. Phys., 259, 163 Wood, B. E., Karovska , M., Chen, J...Reconstructing the Morphology of an Evolving Coronal Mass Ejection B. E. Wood, R. A . Howard, D. G. Socker Naval Research Laboratory, Space Science...mission, we empirically reconstruct the time-dependent three-dimensional morphology of a coronal mass ejection (CME) from 2008 June 1, which exhibits

Challenges to Inquiry Teaching and Suggestions for How to Meet Them

ERIC Educational Resources Information Center

Quigley, Cassie; Marshall, Jeff C.; Deaton, Cynthia C. M.; Cook, Michelle P.; Padilla, Michael

2011-01-01

Inquiry has been cited as an essential goal of science education for decades. While terminology has evolved over time, the notion that students need to apply various analytic and thought related skills in order to better learn underlying scientific concepts and processes, remains central to science education. This article looks at four major…

On the evolving open peer review culture for chemical information science.

PubMed

Walters, W Patrick; Bajorath, Jürgen

2015-01-01

Compared to the traditional anonymous peer review process, open post-publication peer review provides additional opportunities -and challenges- for reviewers to judge scientific studies. In this editorial, we comment on the open peer review culture and provide some guidance for reviewers of manuscripts submitted to the Chemical Information Science channel of F1000Research.

P-hacking.

PubMed

Raj, A Thirumal; Patil, Shankargouda; Sarode, Sachin; Sarode, Gargi

2017-08-01

Due to increasing rate of research articles getting published in recent times, medical science is evolving very fast. Open access policies of the journals make information easily available to the stakeholders for building future research proposal. Blindly having faith in whatever is published in the literature is detrimental for science; however, it is hard to find out the correctness of the data analysis.

Translating Basic Behavioral and Social Science Research to Clinical Application: The EVOLVE Mixed Methods Approach

ERIC Educational Resources Information Center

Peterson, Janey C.; Czajkowski, Susan; Charlson, Mary E.; Link, Alissa R.; Wells, Martin T.; Isen, Alice M.; Mancuso, Carol A.; Allegrante, John P.; Boutin-Foster, Carla; Ogedegbe, Gbenga; Jobe, Jared B.

2013-01-01

Objective: To describe a mixed-methods approach to develop and test a basic behavioral science-informed intervention to motivate behavior change in 3 high-risk clinical populations. Our theoretically derived intervention comprised a combination of positive affect and self-affirmation (PA/SA), which we applied to 3 clinical chronic disease…

An Evolving Controversy: The Struggle to Teach Science in Science Classes

ERIC Educational Resources Information Center

Berkman, Michael; Plutzer, Eric

2012-01-01

Although the level of controversy varies from one community to the next, biology teachers across the United States struggle to teach evolution. Some face pressure to teach both religious and scientific theories of human origins; others did not have adequate coursework on evolution during teacher preparation. As a result, many biology teachers are…

Health Sciences Libraries Forecasting Information Service Trends for Researchers: Models Applicable to All Academic Libraries

ERIC Educational Resources Information Center

Cain, Timothy J.; Cheek, Fern M.; Kupsco, Jeremy; Hartel, Lynda J.; Getselman, Anna

2016-01-01

To better understand the value of current information services and to forecast the evolving information and data management needs of researchers, a study was conducted at two research-intensive universities. The methodology and planning framework applied by health science librarians at Emory University and The Ohio State University focused on…

Opening Possibilities in Experimental Science and Its History: Critical Explorations with Pendulums and Singing Tubes

ERIC Educational Resources Information Center

Cavicchi, Elizabeth

2008-01-01

A teacher and a college student explore experimental science and its history by reading historical texts, and responding with replications and experiments of their own. A curriculum of ever-widening possibilities evolves in their ongoing interactions with each other, history, and such materials as pendulums, flame, and resonant singing tubes.…

Information Science and the Martial Arts: Perspectives on Online Searching.

ERIC Educational Resources Information Center

Raitt, David I.

The relatively new discipline of information science has its origins in the West, while the ancient martial arts have their origins in the East. Despite these differences in age and hemisphere, the two disciplines can be shown to possess many conceptual as well as technical similarities which have evolved quite independently of each other. This…

Unlocking Learning Using Tony Ryan's "Thinker's Keys"

ERIC Educational Resources Information Center

Robinson, Linda

2017-01-01

The learning of science keeps evolving, just like the subject of science itself. With this in mind, teachers know the importance of keeping up to date and researching different ways of providing a rich learning experience for children. Teachers are developing not only children's learning, but how they progress as learners. This is where Tony…

The maintenance of sex: Ronald Fisher meets the Red Queen.

PubMed

Green, David; Mason, Chris

2013-08-21

Sex in higher diploids carries a two-fold cost of males that should reduce its fitness relative to cloning, and result in its extinction. Instead, sex is widespread and clonal species face early obsolescence. One possible reason is that sex is an adaptation that allows organisms to respond more effectively to endless changes in their environment. The purpose of this study was to model mutation and selection in a diploid organism in an evolving environment and ascertain their support for sex. We used a computational approach to model finite populations where a haploid environment subjects a diploid host to endlessly evolving change. Evolution in both populations is primarily through adoption of novel advantageous mutations within a large allele space. Sex outcompetes cloning by two complementary mechanisms. First, sexual diploids adopt advantageous homozygous mutations more rapidly than clonal ones under conditions of lag load (the gap between the actual adaptation of the diploid population and its theoretical optimum). This rate advantage can offset the higher fecundity of cloning. Second, a relative advantage to sex emerges where populations are significantly polymorphic, because clonal polymorphism runs the risk of clonal interference caused by selection on numerous lines of similar adaptation. This interference extends allele lifetime and reduces the rate of adaptation. Sex abolishes the interference, making selection faster and elevating population fitness. Differences in adaptation between sexual and clonal populations increase markedly with the number of loci under selection, the rate of mutation in the host, and a rapidly evolving environment. Clonal interference in these circumstances leads to conditions where the greater fecundity of clones is unable to offset their poor adaptation. Sexual and clonal populations then either co-exist, or sex emerges as the more stable evolutionary strategy. Sex can out-compete clones in a rapidly evolving environment, such as that characterized by pathogens, where clonal interference reduces the adaptation of clonal populations and clones adopt advantageous mutations more slowly. Since all organisms carry parasitic loads, the model is of potentially general applicability.

Architectural Lessons: Look Back In Order To Move Forward

NASA Astrophysics Data System (ADS)

Huang, T.; Djorgovski, S. G.; Caltagirone, S.; Crichton, D. J.; Hughes, J. S.; Law, E.; Pilone, D.; Pilone, T.; Mahabal, A.

2015-12-01

True elegance of scalable and adaptable architecture is not about incorporating the latest and greatest technologies. Its elegance is measured by its ability to scale and adapt as its operating environment evolves over time. Architecture is the link that bridges people, process, policies, interfaces, and technologies. Architectural development begins by observe the relationships which really matter to the problem domain. It follows by the creation of a single, shared, evolving, pattern language, which everyone contributes to, and everyone can use [C. Alexander, 1979]. Architects are the true artists. Like all masterpieces, the values and strength of architectures are measured not by the volumes of publications, it is measured by its ability to evolve. An architect must look back in order to move forward. This talk discusses some of the prior works including onboard data analysis system, knowledgebase system, cloud-based Big Data platform, as enablers to help shape the new generation of Earth Science projects at NASA and EarthCube where a community-driven architecture is the key to enable data-intensive science. [C. Alexander, The Timeless Way of Building, Oxford University, 1979.

Building A Cloud Based Distributed Active Data Archive Center

NASA Technical Reports Server (NTRS)

Ramachandran, Rahul; Baynes, Katie; Murphy, Kevin

2017-01-01

NASA's Earth Science Data System (ESDS) Program facilitates the implementation of NASA's Earth Science strategic plan, which is committed to the full and open sharing of Earth science data obtained from NASA instruments to all users. The Earth Science Data information System (ESDIS) project manages the Earth Observing System Data and Information System (EOSDIS). Data within EOSDIS are held at Distributed Active Archive Centers (DAACs). One of the key responsibilities of the ESDS Program is to continuously evolve the entire data and information system to maximize returns on the collected NASA data.

The Influence of Accelerator Science on Physics Research

NASA Astrophysics Data System (ADS)

Haussecker, Enzo F.; Chao, Alexander W.

2011-06-01

We evaluate accelerator science in the context of its contributions to the physics community. We address the problem of quantifying these contributions and present a scheme for a numerical evaluation of them. We show by using a statistical sample of important developments in modern physics that accelerator science has influenced 28% of post-1938 physicists and also 28% of post-1938 physics research. We also examine how the influence of accelerator science has evolved over time, and show that on average it has contributed to a physics Nobel Prize-winning research every 2.9 years.

Directed Field Ionization: A Genetic Algorithm for Evolving Electric Field Pulses

NASA Astrophysics Data System (ADS)

Kang, Xinyue; Rowley, Zoe A.; Carroll, Thomas J.; Noel, Michael W.

2017-04-01

When an ionizing electric field pulse is applied to a Rydberg atom, the electron's amplitude traverses many avoided crossings among the Stark levels as the field increases. The resulting superposition determines the shape of the time resolved field ionization spectrum at a detector. An engineered electric field pulse that sweeps back and forth through avoided crossings can control the phase evolution so as to determine the electron's path through the Stark map. In the region of n = 35 in rubidium there are hundreds of potential avoided crossings; this yields a large space of possible pulses. We use a genetic algorithm to search this space and evolve electric field pulses to direct the ionization of the Rydberg electron in rubidium. We present the algorithm along with a comparison of simulated and experimental results. This work was supported by the National Science Foundation under Grants No. 1607335 and No. 1607377 and used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation Grant Number OCI-1053575.

A New Generation of Telecommunications for Mars: The Reconfigurable Software Radio

NASA Technical Reports Server (NTRS)

Adams, J.; Horne, W.

2000-01-01

Telecommunications is a critical component for any mission at Mars as it is an enabling function that provides connectivity back to Earth and provides a means for conducting science. New developments in telecommunications, specifically in software - configurable radios, expand the possible approaches for science missions at Mars. These radios provide a flexible and re-configurable platform that can evolve with the mission and that provide an integrated approach to communications and science data processing. Deep space telecommunication faces challenges not normally faced by terrestrial and near-earth communications. Radiation, thermal, highly constrained mass, volume, packaging and reliability all are significant issues. Additionally, once the spacecraft leaves earth, there is no way to go out and upgrade or replace radio components. The reconfigurable software radio is an effort to provide not only a product that is immediately usable in the harsh space environment but also to develop a radio that will stay current as the years pass and technologies evolve.

State of the Data Union, 1992

NASA Technical Reports Server (NTRS)

1992-01-01

This is the first report on the State of the Data Union (SDU) for the NASA Office of Space Science and Applications (OSSA). OSSA responsibilities include the collection, analysis, and permanent archival of data critical to space science research. The nature of how this is done by OSSA is evolving to keep pace with changes in space research. Current and planned missions have evolved to be more complex and multidisciplinary, and are generating much more data and lasting longer than earlier missions. New technologies enable global access to data, transfer of huge volumes of data, and increasingly complex analysis. The SDU provides a snapshot of this dynamic environment, identifying trends in capabilities and requirements. The current space science data environment is described and parameters which capture the pulse of key functions within that environment are presented. Continuous efforts of OSSA to improve the availability and quality of data provided to the scientific community are reported, highlighting efforts such as the Data Management Initiative.

Experimental evolution of insect immune memory versus pathogen resistance.

PubMed

Khan, Imroze; Prakash, Arun; Agashe, Deepa

2017-12-20

Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory (immune priming), whereby sublethal exposure to a pathogen enhances survival after secondary infection. Theory predicts that immune memory should evolve when the pathogen is highly virulent, or when pathogen exposure is relatively rare. However, there are no empirical tests of these hypotheses, and the adaptive benefits of immune memory relative to direct resistance against a pathogen are poorly understood. To determine the selective pressures and ecological conditions that shape immune evolution, we imposed strong pathogen selection on flour beetle ( Tribolium castaneum ) populations, infecting them with Bacillus thuringiensis (Bt) for 11 generations. Populations injected first with heat-killed and then live Bt evolved high basal resistance against multiple Bt strains. By contrast, populations injected only with a high dose of live Bt evolved a less effective but strain-specific priming response. Control populations injected with heat-killed Bt did not evolve priming; and in the ancestor, priming was effective only against a low Bt dose. Intriguingly, one replicate population first evolved priming and subsequently evolved basal resistance, suggesting the potential for dynamic evolution of different immune strategies. Our work is the first report showing that pathogens can select for rapid modulation of insect priming ability, allowing hosts to evolve divergent immune strategies (generalized resistance versus specific immune memory) with potentially distinct mechanisms. © 2017 The Author(s).

New Science Enabled by the NASA TROPICS CubeSat Constellation Mission

NASA Astrophysics Data System (ADS)

Blackwell, W. J.; Braun, S. A.; Bennartz, R.; Velden, C.; Demaria, M.; Atlas, R. M.; Dunion, J. P.; Marks, F.; Rogers, R. F.; Annane, B.

2017-12-01

Recent technology advances in miniature microwave radiometers that can be hosted on very small satellites has made possible a new class of affordable constellation missions that provide very high revisit rates of tropical cyclones and other severe weather. The Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS) mission was selected by NASA as part of the Earth Venture-Instrument (EVI-3) program and is now in development with planned launch readiness in late 2019. The overarching goal for TROPICS is to provide nearly all-weather observations of 3-D temperature and humidity, as well as cloud ice and precipitation horizontal structure, at high temporal resolution to conduct high-value science investigations of tropical cyclones, including: (1) relationships of rapidly evolving precipitation and upper cloud structures to upper-level warm-core intensity and associated storm intensity changes; (2) the evolution of precipitation structure and storm intensification in relationship to environmental humidity fields; and (3) the impact of rapid-update observations on numerical and statistical intensity forecasts of tropical cyclones. TROPICS will provide rapid-refresh microwave measurements (median refresh rate better than 60 minutes for the baseline mission) over the tropics that can be used to observe the thermodynamics of the troposphere and precipitation structure for storm systems at the mesoscale and synoptic scale over the entire storm lifecycle. TROPICS comprises a constellation of six CubeSats in three low-Earth orbital planes. Each CubeSat will host a high performance radiometer to provide temperature profiles using seven channels near the 118.75 GHz oxygen absorption line, water vapor profiles using 3 channels near the 183 GHz water vapor absorption line, imagery in a single channel near 90 GHz for precipitation measurements (when combined with higher resolution water vapor channels), and a single channel at 206 GHz that is more sensitive to precipitation-sized ice particles. This observing system offers an unprecedented combination of horizontal and temporal resolution to measure environmental and inner-core conditions for tropical cyclones on a nearly global scale.

Global Implications of late Pleistocene Megafaunal Extinctions in the Holarctic

NASA Astrophysics Data System (ADS)

Cooper, Alan; Turney, Chris

2017-04-01

Improved resolution data from radiocarbon, climate and ancient DNA studies of megafauna and humans is providing the first ability to disentangle the roles of climate change and human impact in the Late Pleistocene megafaunal extinctions. In the Holarctic we find that megafaunal populations underwent repeated local or global extinctions apparently associated with abrupt, centennial to millennial duration warming events (Dansgaard-Oeschger interstadials). Importantly, the extinction events took place both before and after the arrival of modern humans in the landscape. Here we look at the possible role of human activity in Holarctic and suggest it may be through the disruption of metapopulation processes which stabilize ecosystems and may have evolved to provide resilience to rapid and frequent climate shifts in the past. The observed relationship between climate and humans on megafaunal populations may provide a model for global extinction. Fortunately in this regard, the rapid movement of the first Native Americans throughout both American continents during the Last Deglaciation provides a powerful and unique model system for testing the competing roles on extinction because the opposing climate trends in each hemisphere at the time. Here we show that while megafaunal extinctions were associated with warming trends in both cases, the out-of-phase climate patterns caused the sequence and timing of events to be mirrored, providing a unique high-resolution view of the interactions of human colonization and rapid climate change on megafaunal ecosystems, with implications for future warming scenarios. References: Cooper, A., Turney, C., Hughen, K.A., Brook, B.W., McDonald, H.G., Bradshaw, C.J.A., 2015. Abrupt warming events drove Late Pleistocene Holarctic megafaunal turnover. Science 349, 602-606. Metcalf, J.L., Turney, C., Barnett, R., Martin, F., Bray, S.C., Vilstrup, J.T., Orlando, L., Salas-Gismondi, R., Loponte, D., Medina, M., De Nigris, M., Civalero, T., Fernández, P.M., Gasco, A., Duran, V., Seymour, K.L., Otaola, C., Gil, A., Paunero, R., Prevosti, F.J., Bradshaw, C.J.A., Wheeler, J.C., Borrero, L., Austin, J.J., Cooper, A., 2016. Synergistic roles of climate warming and human occupation in Patagonian megafaunal extinctions during the Last Deglaciation. Science Advances 2, doi: 10.1126/sciadv.1501682.

Insights into the Sulfur Mineralogy of Martian Soil at Rocknest, Gale Crater, Enabled by Evolved Gas Analyses

NASA Technical Reports Server (NTRS)

McAdam, A.; Franz, H.; Archer, P., Jr.; Freissinet, C.; Sutter, B.; Glavin, D.; Eigenbrode, J.; Bower, H.; Stern, J.; Mchaffy, P.;

Extinction events can accelerate evolution.

PubMed

Lehman, Joel; Miikkulainen, Risto

2015-01-01

Extinction events impact the trajectory of biological evolution significantly. They are often viewed as upheavals to the evolutionary process. In contrast, this paper supports the hypothesis that although they are unpredictably destructive, extinction events may in the long term accelerate evolution by increasing evolvability. In particular, if extinction events extinguish indiscriminately many ways of life, indirectly they may select for the ability to expand rapidly through vacated niches. Lineages with such an ability are more likely to persist through multiple extinctions. Lending computational support for this hypothesis, this paper shows how increased evolvability will result from simulated extinction events in two computational models of evolved behavior. The conclusion is that although they are destructive in the short term, extinction events may make evolution more prolific in the long term.

Constructing professional and organisational fields.

PubMed

Gurney, Robert

2016-01-01

Purpose - The purpose of this paper is to fill an apparent gap in the literature addressing issues of leadership and change - the development and activities of constructing and leading sports sciences and medicine professions, and similarly, the construction and leadership of multidisciplinary/inter-disciplinary organisations that practice sports sciences and medicine. Design/methodology/approach - This study incorporated explorations through conducting both interviews and survey questionnaires with members of Sports Medicine Australia (SMA). The interviews (qualitative) were semi-structured and asked questions addressing what changed, why change and how change was implemented. Findings - The health sciences and medicine professions moving to specialised sports sciences and medicine disciplines and SMA, evolved through forces driving the need for change (legitimacy, resource dependency, positioning and core competencies). Practical implications - The knowledge developed from understanding activities of change that traditional professions conducted to become specialised Disciplines and parallel changes in a single Discipline organisation evolving to an umbrella organisation (SMA), comprised a membership of specialised Disciplines, can act as a catalyst for inquiry by other professional and organisational groups. Originality/value - The findings of this study contributes to the literature investigating change in professional and organisations fields. More specifically, this study promotes inquiry into leadership practices of sports sciences and medicine, as contributors to the field of health services.

Enhancer Evolution across 20 Mammalian Species

PubMed Central

Villar, Diego; Berthelot, Camille; Aldridge, Sarah; Rayner, Tim F.; Lukk, Margus; Pignatelli, Miguel; Park, Thomas J.; Deaville, Robert; Erichsen, Jonathan T.; Jasinska, Anna J.; Turner, James M.A.; Bertelsen, Mads F.; Murchison, Elizabeth P.; Flicek, Paul; Odom, Duncan T.

2015-01-01

Summary The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully conserved across these species. Our data further reveal that recently evolved enhancers can be associated with genes under positive selection, demonstrating the power of this approach for annotating regulatory adaptations in genomic sequences. These results provide important insight into the functional genetics underpinning mammalian regulatory evolution. PMID:25635462

Intracardiac metastasis originated from chondrosarcoma.

PubMed

Maurea, Nicola; Ragone, Gianluca; Coppola, Carmela; Caronna, Antonietta; Tocchetti, Carlo G; Agozzino, Lucio; Apice, Gaetano; Iaffaioli, Rosario V

2017-05-01

Primary cardiac tumors are extremely rare. By comparison, metastatic involvement of the heart is over 20 times more common and has been reported in autopsy series in up to one in five patients dying of cancer. Cardiac metastasis of chondrosarcoma is absolutely not frequent. In the recent literature, a cardiac metastasis from chondrosarcoma has never been described. We report the case of an 18-year-old man with a diagnosis of cardiac metastasis that originated from a left scapular chondrosarcoma. Chondrosarcoma is a skeletal tumor with various grades of malignancy, rapidly evolving, and with a strong tendency to metastasize, with low responsiveness to chemotherapy. The onset of characteristic systemic symptoms in the late stage of the disease led to the diagnosis of a mass localized in the right atrium. Management and differential diagnosis of infective heart lesions were also very complex in a rapidly evolving life-threatening condition.

Evolving food retail environments in Thailand and implications for the health and nutrition transition

PubMed Central

Banwell, Cathy; Dixon, Jane; Seubsman, Sam-ang; Pangsap, Suttinan; Kelly, Matthew; Sleigh, Adrian

2013-01-01

Objective An investigation into evolving food retail systems in Thailand Design Rapid assessment procedures based on qualitative research methods such as interviews, focus groups discussions and site visits Setting Seven freshmarkets located in the four main regions of Thailand Subjects Managers, food specialists, vendors and shoppers from seven freshmarkets who participated in interviews and focus group discussions. Results Freshmarkets are under economic pressure and are declining in number. They are attempting to resist the competition from supermarkets by improving convenience, food diversity, quality and safety. Conclusions Obesity has increased in Thailand at the same time as rapid growth of modern food retail formats has occurred. As freshmarkets are overtaken by supermarkets there is a likely loss of fresh, healthy, affordable food for poorer Thais, and a diminution of regional culinary culture, women’s jobs and social capital with implications for the health and nutrition transition in Thailand. PMID:23021291

Sex determination: why so many ways of doing it?

PubMed

Bachtrog, Doris; Mank, Judith E; Peichel, Catherine L; Kirkpatrick, Mark; Otto, Sarah P; Ashman, Tia-Lynn; Hahn, Matthew W; Kitano, Jun; Mayrose, Itay; Ming, Ray; Perrin, Nicolas; Ross, Laura; Valenzuela, Nicole; Vamosi, Jana C

2014-07-01

Sexual reproduction is an ancient feature of life on earth, and the familiar X and Y chromosomes in humans and other model species have led to the impression that sex determination mechanisms are old and conserved. In fact, males and females are determined by diverse mechanisms that evolve rapidly in many taxa. Yet this diversity in primary sex-determining signals is coupled with conserved molecular pathways that trigger male or female development. Conflicting selection on different parts of the genome and on the two sexes may drive many of these transitions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studied. Here we survey our current understanding of how and why sex determination evolves in animals and plants and identify important gaps in our knowledge that present exciting research opportunities to characterize the evolutionary forces and molecular pathways underlying the evolution of sex determination.

Sex Determination: Why So Many Ways of Doing It?

PubMed Central

Bachtrog, Doris; Mank, Judith E.; Peichel, Catherine L.; Kirkpatrick, Mark; Otto, Sarah P.; Ashman, Tia-Lynn; Hahn, Matthew W.; Kitano, Jun; Mayrose, Itay; Ming, Ray; Perrin, Nicolas; Ross, Laura; Valenzuela, Nicole; Vamosi, Jana C.

2014-01-01

Sexual reproduction is an ancient feature of life on earth, and the familiar X and Y chromosomes in humans and other model species have led to the impression that sex determination mechanisms are old and conserved. In fact, males and females are determined by diverse mechanisms that evolve rapidly in many taxa. Yet this diversity in primary sex-determining signals is coupled with conserved molecular pathways that trigger male or female development. Conflicting selection on different parts of the genome and on the two sexes may drive many of these transitions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studied. Here we survey our current understanding of how and why sex determination evolves in animals and plants and identify important gaps in our knowledge that present exciting research opportunities to characterize the evolutionary forces and molecular pathways underlying the evolution of sex determination. PMID:24983465

Evolving food retail environments in Thailand and implications for the health and nutrition transition.

PubMed

Banwell, Cathy; Dixon, Jane; Seubsman, Sam-Ang; Pangsap, S; Kelly, Matthew; Sleigh, Adrian

2013-04-01

To investigate evolving food retail systems in Thailand. Rapid assessment procedures based on qualitative research methods including interviews, focus groups discussions and site visits. Seven fresh markets located in the four main regions of Thailand. Managers, food specialists, vendors and shoppers from seven fresh markets who participated in interviews and focus group discussions. Fresh markets are under economic pressure and are declining in number. They are attempting to resist the competition from supermarkets by improving convenience, food diversity, quality and safety. Obesity has increased in Thailand at the same time as rapid growth of modern food retail formats has occurred. As fresh markets are overtaken by supermarkets there is a likely loss of fresh, healthy, affordable food for poorer Thais, and a diminution of regional culinary culture, women's jobs and social capital, with implications for the health and nutrition transition in Thailand.

Evolution of the chalcone synthase gene family in the genus Ipomoea.

PubMed Central

Durbin, M L; Learn, G H; Huttley, G A; Clegg, M T

1995-01-01

The evolution of the chalcone synthase [CHS; malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing), EC 2.3.1.74] multigene family in the genus Ipomoea is explored. Thirteen CHS genes from seven Ipomoea species (family Convolvulaceae) were sequenced--three from genomic clones and the remainder from PCR amplification with primers designed from the 5' flanking region and the end of the 3' coding region of Ipomoea purpurea Roth. Analysis of the data indicates a duplication of CHS that predates the divergence of the Ipomoea species in this study. The Ipomoea CHS genes are among the most rapidly evolving of the CHS genes sequenced to date. The CHS genes in this study are most closely related to the Petunia CHS-B gene, which is also rapidly evolving and highly divergent from the rest of the Petunia CHS sequences. PMID:7724563

A Bright Future: Innovation Transforming Public Health in Chicago

PubMed Central

Choucair, Bechara; Bhatt, Jay; Mansour, Raed

2015-01-01

Big cities continue to be centers for innovative solutions and services. Governments are quickly identifying opportunities to take advantage of this energy and revolutionize the means by which they deliver services to the public. The governmental public health sector is rapidly evolving in this respect, and Chicago is an emerging example of some of the changes to come. Governments are gradually adopting innovative informatics and big data tools and strategies, led by pioneering jurisdictions that are piecing together the standards, policy frameworks, and leadership structures fundamental to effective analytics use. They give an enticing glimpse of the technology's potential and a sense of the challenges that stand in the way. This is a rapidly evolving environment, and cities can work with partners to capitalize on the innovative energies of civic tech communities, health care systems, and emerging markets to introduce new methods to solve old problems. PMID:25423057

A bright future: innovation transforming public health in Chicago.

PubMed

Choucair, Bechara; Bhatt, Jay; Mansour, Raed

2015-01-01

Big cities continue to be centers for innovative solutions and services. Governments are quickly identifying opportunities to take advantage of this energy and revolutionize the means by which they deliver services to the public. The governmental public health sector is rapidly evolving in this respect, and Chicago is an emerging example of some of the changes to come. Governments are gradually adopting innovative informatics and big data tools and strategies, led by pioneering jurisdictions that are piecing together the standards, policy frameworks, and leadership structures fundamental to effective analytics use. They give an enticing glimpse of the technology's potential and a sense of the challenges that stand in the way. This is a rapidly evolving environment, and cities can work with partners to capitalize on the innovative energies of civic tech communities, health care systems, and emerging markets to introduce new methods to solve old problems.

Evolution of Information Systems Curriculum in an Australian University over the Last Twenty-Five Years

NASA Astrophysics Data System (ADS)

Tatnall, Arthur; Burgess, Stephen

Information Systems (IS) courses began in Australia’s higher education institutions in the 1960, and have continued to evolve at a rapid rate since then. Beginning with a need by the Australian Commonwealth Government for a large number of computer professionals, Information Systems (or Business Computing) courses developed rapidly. The nature and content of these courses in the 1960s and 70s, however, was quite different to present courses and this paper traces this change and the reasons for it. After some brief discussion of the beginnings and the early days of Information Systems curriculum, we address in particular how these courses have evolved in one Australian university over the last 25 years. IS curriculum is seen to adapt, new materials are added and emphases changed as new technologies and new computing applications emerge. The paper offers a model of how curriculum change in Information Systems takes place.

Practical Lessons From the First Decade of EPO Partnership Between NIRCam/JWST and the GSUSA

NASA Astrophysics Data System (ADS)

McCarthy, D.; Lebofsky, L. A.; Schlingman, W. M.; Higgins, M. L.

2013-04-01

Ten years ago the NIRCam science team proposed to conduct “Train the Trainer” workshops for adult leaders from all Girl Scout Councils in the U.S. with an aim to improving basic astronomy materials and to conveying mission-specific information about the science and technologies associated with the James Webb Space Telescope (JWST). To date we have conducted 20 workshops involving 225 adult leaders (41 U.S. states, Guam, Japan). During this time, the infrastructure of the GSUSA has evolved considerably, as has its approach to STEM education. Here we discuss how our ongoing workshops, educational activities, and our network of trained leaders have evolved to meet the continuing needs of girls and young women within the GSUSA's new framework of Journeys.

Differential Scanning Calorimetry and Evolved Gas Analysis at Mars Ambient Conditions Using the Thermal Evolved Gas Analyzer (TEGA)

NASA Technical Reports Server (NTRS)

Musselwhite, D. S.; Boynton, W. V.; Ming, Douglas W.; Quadlander, G.; Kerry, K. E.; Bode, R. C.; Bailey, S. H.; Ward, M. G.; Pathare, A. V.; Lorenz, R. D.

2000-01-01

Differential Scanning Calorimetry (DSC) combined with evolved gas analysis (EGA) is a well developed technique for the analysis of a wide variety of sample types with broad application in material and soil sciences. However, the use of the technique for samples under conditions of pressure and temperature as found on other planets is one of current C development and cutting edge research. The Thermal Evolved Gas Analyzer (MGA), which was designed, built and tested at the University of Arizona's Lunar and Planetary Lab (LPL), utilizes DSC/EGA. TEGA, which was sent to Mars on the ill-fated Mars Polar Lander, was to be the first application of DSC/EGA on the surface of Mars as well as the first direct measurement of the volatile-bearing mineralogy in martian soil.

Identifying Key Features, Cutting Edge Cloud Resources, and Artificial Intelligence Tools to Achieve User-Friendly Water Science in the Cloud

NASA Astrophysics Data System (ADS)

Pierce, S. A.

2017-12-01

Decision making for groundwater systems is becoming increasingly important, as shifting water demands increasingly impact aquifers. As buffer systems, aquifers provide room for resilient responses and augment the actual timeframe for hydrological response. Yet the pace impacts, climate shifts, and degradation of water resources is accelerating. To meet these new drivers, groundwater science is transitioning toward the emerging field of Integrated Water Resources Management, or IWRM. IWRM incorporates a broad array of dimensions, methods, and tools to address problems that tend to be complex. Computational tools and accessible cyberinfrastructure (CI) are needed to cross the chasm between science and society. Fortunately cloud computing environments, such as the new Jetstream system, are evolving rapidly. While still targeting scientific user groups systems such as, Jetstream, offer configurable cyberinfrastructure to enable interactive computing and data analysis resources on demand. The web-based interfaces allow researchers to rapidly customize virtual machines, modify computing architecture and increase the usability and access for broader audiences to advanced compute environments. The result enables dexterous configurations and opening up opportunities for IWRM modelers to expand the reach of analyses, number of case studies, and quality of engagement with stakeholders and decision makers. The acute need to identify improved IWRM solutions paired with advanced computational resources refocuses the attention of IWRM researchers on applications, workflows, and intelligent systems that are capable of accelerating progress. IWRM must address key drivers of community concern, implement transdisciplinary methodologies, adapt and apply decision support tools in order to effectively support decisions about groundwater resource management. This presentation will provide an overview of advanced computing services in the cloud using integrated groundwater management case studies to highlight how Cloud CI streamlines the process for setting up an interactive decision support system. Moreover, advances in artificial intelligence offer new techniques for old problems from integrating data to adaptive sensing or from interactive dashboards to optimizing multi-attribute problems. The combination of scientific expertise, flexible cloud computing solutions, and intelligent systems opens new research horizons.

Clinical use and misuse of automated semen analysis.

PubMed

Sherins, R J

1991-01-01

During the past six years, there has been an explosion of technology which allows automated machine-vision for sperm analysis. CASA clearly provides an opportunity for objective, systematic assessment of sperm motion. But there are many caveats in using this type of equipment. CASA requires a disciplined and standardized approach to semen collection, specimen preparation, machine settings, calibration and avoidance of sampling bias. Potential sources of error can be minimized. Unfortunately, the rapid commercialization of this technology preceded detailed statistical analysis of such data to allow equally rapid comparisons of data between different CASA machines and among different laboratories. Thus, it is now imperative that we standardize use of this technology and obtain more detailed biological insights into sperm motion parameters in semen and after capacitation before we empirically employ CASA for studies of fertility prediction. In the basic science arena, CASA technology will likely evolve to provide new algorithms for accurate sperm motion analysis and give us an opportunity to address the biophysics of sperm movement. In the clinical arena, CASA instruments provide the opportunity to share and compare sperm motion data among laboratories by virtue of its objectivity, assuming standardized conditions of utilization. Identification of men with specific sperm motion disorders is certain, but the biological relevance of motility dysfunction to actual fertilization remains uncertain and surely the subject for further study.

The MSFC Collaborative Engineering Process for Preliminary Design and Concept Definition Studies

NASA Technical Reports Server (NTRS)

Mulqueen, Jack; Jones, David; Hopkins, Randy

2011-01-01

This paper describes a collaborative engineering process developed by the Marshall Space Flight Center's Advanced Concepts Office for performing rapid preliminary design and mission concept definition studies for potential future NASA missions. The process has been developed and demonstrated for a broad range of mission studies including human space exploration missions, space transportation system studies and in-space science missions. The paper will describe the design team structure and specialized analytical tools that have been developed to enable a unique rapid design process. The collaborative engineering process consists of integrated analysis approach for mission definition, vehicle definition and system engineering. The relevance of the collaborative process elements to the standard NASA NPR 7120.1 system engineering process will be demonstrated. The study definition process flow for each study discipline will be will be outlined beginning with the study planning process, followed by definition of ground rules and assumptions, definition of study trades, mission analysis and subsystem analyses leading to a standardized set of mission concept study products. The flexibility of the collaborative engineering design process to accommodate a wide range of study objectives from technology definition and requirements definition to preliminary design studies will be addressed. The paper will also describe the applicability of the collaborative engineering process to include an integrated systems analysis approach for evaluating the functional requirements of evolving system technologies and capabilities needed to meet the needs of future NASA programs.

Mechatronics: the future of mechanical engineering; past, present, and a vision for the future

NASA Astrophysics Data System (ADS)

Ramasubramanian, M. K.

2001-08-01

Mechatronics is the synergistic integration of precision mechanical engineering, electronics, computational hardware and software in the design of products and processes. Mechatronics, the term coined in Japan in the '70s, has evolved to symbolize what mechanical design engineers do today worldwide. The revolutionary introduction of the microprocessor (or microcontroller) in the early '80s and ever increasing performance-cost ratio has changed the paradigm of mechanical design forever, and has broadened the original definition of mechatronics to include intelligent control and autonomous decision-making. Today, increasing number of new products is being developed at the intersection between traditional disciplines of Engineering, and Computer and Material Sciences. New developments in these traditional disciplines are being absorbed into mechatronics design at an ever-increasing pace. In this paper, a brief history of mechatronics, and several examples of this rapid adaptation of technologies into product design is presented. With the ongoing information technology revolution, especially in wireless communication, smart sensors design (enabled by MEMS technology), and embedded systems engineering, mechatronics design is going through another step change in capabilities and scope. The implications of these developments in mechatronics design in the near future are discussed. Finally, deficiencies in our engineering curriculum to address the needs of the industry to cope up with these rapid changes, and proposed remedies, will also be discussed.

Initialization, Prediction and Diagnosis of the Rapid Intensification of Tropical Cyclones using the Australian Community Climate and Earth System Simulator, ACCESS

DTIC Science & Technology

2012-10-12

structure on the evolving storm behaviour. 13 7. Large scale influences on Rapid Intensification and Extratropical Transition: RI and ET...assimilation techniques to better initialize and validate TC structures (including the intense inner core and storm asymmetries) consistent with the large...Without vortex specification, initial conditions usually contain a weak and misplaced circulation. Based on estimates of central pressure and storm size

DEVELOPING A PROBLEM-BASED LEARNING (PBL) CURRICULUM FOR PROFESSIONALISM AND ETHICS TRAINING FOR BIOMEDICAL GRADUATE STUDENTS

PubMed Central

Jones, Nancy L.; Peiffer, Ann M.; Lambros, Ann; Guthold, Martin; Johnson, A. Daniel; Tytell, Michael; Ronca, April E.; Eldridge, J. Charles

2013-01-01

A curriculum was designed to shape biomedical graduate students into researchers with a high commitment to professionalism and social responsibility, and to provide students with tools to navigate the complex, rapidly evolving academic and societal environments with a strong ethical commitment. Problem-Based Learning (PBL) pedagogy was chosen because it is active, learner-centered, and focuses on skill and process development. Additionally, the small group format provides a high degree of socialization around professional norms. Two courses were developed. Scientific Professionalism Scientific Integrity addressed discipline-specific and broad professional norms and obligations for the ethical practice of science and responsible conduct of research (RCR). Scientific Professionalism Bioethics and Social Responsibility focused on current ethical and bioethical issues within the scientific profession and implications of research for society. Each small-group session examined case scenarios that included: (1) learning objectives for professional norms and obligations; (2) key ethical issues and philosophies within each topic area; (3) one or more of the RCR instructional areas; and (4) at least one type of moral reflection. Cases went beyond covering overt research misconduct to emphasize professional standards, obligations, and underlying philosophies for the ethical practice of science, competing interests of stakeholders, and oversight of science (internal and external). To our knowledge this was the first use of PBL to teach scientific integrity and ethics. Both faculty and students at Wake Forest endorsed the orientation of professionalism, active learning, and acquiring skills in contrast to a compliance-based approach that emphasizes learning rules and regulations. PMID:20797979

The CYGNSS flight segment; A major NASA science mission enabled by micro-satellite technology

NASA Astrophysics Data System (ADS)

Rose, R.; Ruf, C.; Rose, D.; Brummitt, M.; Ridley, A.

While hurricane track forecasts have improved in accuracy by ~50% since 1990, there has been essentially no improvement in the accuracy of intensity prediction. This lack of progress is thought to be caused by inadequate observations and modeling of the inner core due to two causes: 1) much of the inner core ocean surface is obscured from conventional remote sensing instruments by intense precipitation in the inner rain bands and 2) the rapidly evolving stages of the tropical cyclone (TC) life cycle are poorly sampled in time by conventional polar-orbiting, wide-swath surface wind imagers. NASA's most recently awarded Earth science mission, the NASA EV-2 Cyclone Global Navigation Satellite System (CYGNSS) has been designed to address these deficiencies by combining the all-weather performance of GNSS bistatic ocean surface scatterometry with the sampling properties of a satellite constellation. This paper provides an overview of the CYGNSS flight segment requirements, implementation, and concept of operations for the CYGNSS constellation; consisting of 8 microsatellite-class spacecraft (<; 100kg) each hosting a GNSS receiver, operating in a 500 km orbit, inclined at 35° to provide 70% coverage of the historical TC track. The CYGNSS mission is enabled by modern electronic technology; it is an example of how nanosatellite technology can be applied to replace traditional "old school" solutions at significantly reduced cost while providing an increase in performance. This paper provides an overview of how we combined a reliable space-flight proven avionics design with selected microsatellite components to create an innovative, low-cost solution for a mainstream science investigation.

"Media, politics and science policy: MS and evidence from the CCSVI Trenches".

PubMed

Pullman, Daryl; Zarzeczny, Amy; Picard, André

2013-02-12

In 2009, Dr. Paolo Zamboni proposed chronic cerebrospinal venous insufficiency (CCSVI) as a possible cause of multiple sclerosis (MS). Although his theory and the associated treatment ("liberation therapy") received little more than passing interest in the international scientific and medical communities, his ideas became the source of tremendous public and political tension in Canada. The story moved rapidly from mainstream media to social networking sites. CCSVI and liberation therapy swiftly garnered support among patients and triggered remarkable and relentless advocacy efforts. Policy makers have responded in a variety of ways to the public's call for action. We present three different perspectives on this evolving story, that of a health journalist who played a key role in the media coverage of this issue, that of a health law and policy scholar who has closely observed the unfolding public policy developments across the country, and that of a medical ethicist who sits on an expert panel convened by the MS Society of Canada and the Canadian Institutes of Health Research to assess the evidence as it emerges. This story raises important questions about resource allocation and priority setting in scientific research and science policy. The growing power of social media represents a new level of citizen engagement and advocacy, and emphasizes the importance of open debate about the basis on which such policy choices are made. It also highlights the different ways evidence may be understood, valued and utilized by various stakeholders and further emphasizes calls to improve science communication so as to support balanced and informed decision-making.

A synthetic design environment for ship design

NASA Technical Reports Server (NTRS)

Chipman, Richard R.

1995-01-01

Rapid advances in computer science and information system technology have made possible the creation of synthetic design environments (SDE) which use virtual prototypes to increase the efficiency and agility of the design process. This next generation of computer-based design tools will rely heavily on simulation and advanced visualization techniques to enable integrated product and process teams to concurrently conceptualize, design, and test a product and its fabrication processes. This paper summarizes a successful demonstration of the feasibility of using a simulation based design environment in the shipbuilding industry. As computer science and information science technologies have evolved, there have been many attempts to apply and integrate the new capabilities into systems for the improvement of the process of design. We see the benefits of those efforts in the abundance of highly reliable, technologically complex products and services in the modern marketplace. Furthermore, the computer-based technologies have been so cost effective that the improvements embodied in modern products have been accompanied by lowered costs. Today the state-of-the-art in computerized design has advanced so dramatically that the focus is no longer on merely improving design methodology; rather the goal is to revolutionize the entire process by which complex products are conceived, designed, fabricated, tested, deployed, operated, maintained, refurbished and eventually decommissioned. By concurrently addressing all life-cycle issues, the basic decision making process within an enterprise will be improved dramatically, leading to new levels of quality, innovation, efficiency, and customer responsiveness. By integrating functions and people with an enterprise, such systems will change the fundamental way American industries are organized, creating companies that are more competitive, creative, and productive.

DORADO/DOLPHIN: A Unique Semi-submersible Autonomous Vehicle for Ocean Field Experiments.

NASA Astrophysics Data System (ADS)

Wallace, D.

2016-02-01

The Ocean Science and Technology research group (CERC.OCEAN) at Dalhousie University focuses on new approaches to the design and development of autonomous platforms to study biogeochemical and ecological changes in the world's oceans. Mesoscale "patch" experiments involving tracers are used to test hypotheses (e.g. iron fertilization) and examine near-surface processes and air-sea exchange. Such experiments typically require mapping of rapidly-evolving properties on scales of 10's to 100's of kilometers. These experiments typically employ a research vessel to monitor patch movement and to support process studies: however allocation of expensive vessel time between these uses can be problematic. We present a class of autonomous vehicle with unique potential for mesoscale mapping and experimental science at sea. The Dorado/Dolphin semi-submersibles, manufactured by International Submarine Engineering Ltd., travel just below the sea surface. A surface-piercing, "snorkel" mast allows use of a diesel engine allowing speeds of up to 16 knots and sufficient power for support of complex payloads. A tow-body can profile to 200m. The mast allows air sampling with near-zero atmospheric disturbance as well as remote sensing of the sea surface. The characteristics of this type of vehicle will be compared with those of other available platforms. We will report on our adaptation of the vehicle for measurement of gases and purposeful tracers (e.g. SF5CF3) as well as properties such as T, S, pCO2, O2, fluorescence, etc. and present and solicit ideas for the vehicles' further application/use for ocean science.

Supporting decisions through the Study of Environmental Arctic Change (SEARCH) Program: A History and Way Forward

NASA Astrophysics Data System (ADS)

Druckenmiller, M. L.; Wiggins, H. V.; Eicken, H.; Francis, J. A.; Huntington, H.; Scambos, T. A.

2015-12-01

The Study of Environmental Arctic Change (SEARCH), ongoing since the early-2000s, aims to develop scientific knowledge to help society understand and respond to the rapidly changing Arctic. Through collaboration with the research community, funding agencies, national and international science programs, and other stakeholders, SEARCH facilitates research activities across local-to-global scales, with increasing emphasis on addressing the information needs of policy and decision-makers. This talk will explore the program's history, spanning its earliest efforts to understand interrelated atmospheric, oceanic, and terrestrial changes in the Arctic to more recent objectives of providing stakeholder-relevant information, such as community-wide summaries of the expected arctic summer sea ice minimum or up-to-date information on sea ice conditions to Alaska Native walrus hunters in the Bering and Chukchi Seas. We will discuss SEARCH's recent shift toward a "Knowledge to Action" vision and implementation of focused Action Teams to: (1) improve understanding, advance prediction, and explore consequences of changing arctic sea ice; (2) document and understand how degradation of near-surface permafrost will affect arctic and global systems; and (3) improve predictions of future land-ice loss and impacts on sea level. Tracking and evaluating how scientific information from such research reaches stakeholders and informs decisions are critical for interactions that allow the research community to keep pace with an evolving landscape of arctic decision-makers. Examples will be given for the new directions these Action Teams are taking regarding science communication and approaches for research community collaboration to synthesize research findings and promote arctic science and interdisciplinary scientific discovery.

“Media, politics and science policy: MS and evidence from the CCSVI Trenches”

PubMed Central

2013-01-01

Background In 2009, Dr. Paolo Zamboni proposed chronic cerebrospinal venous insufficiency (CCSVI) as a possible cause of multiple sclerosis (MS). Although his theory and the associated treatment (“liberation therapy”) received little more than passing interest in the international scientific and medical communities, his ideas became the source of tremendous public and political tension in Canada. The story moved rapidly from mainstream media to social networking sites. CCSVI and liberation therapy swiftly garnered support among patients and triggered remarkable and relentless advocacy efforts. Policy makers have responded in a variety of ways to the public’s call for action. Discussion We present three different perspectives on this evolving story, that of a health journalist who played a key role in the media coverage of this issue, that of a health law and policy scholar who has closely observed the unfolding public policy developments across the country, and that of a medical ethicist who sits on an expert panel convened by the MS Society of Canada and the Canadian Institutes of Health Research to assess the evidence as it emerges. Summary This story raises important questions about resource allocation and priority setting in scientific research and science policy. The growing power of social media represents a new level of citizen engagement and advocacy, and emphasizes the importance of open debate about the basis on which such policy choices are made. It also highlights the different ways evidence may be understood, valued and utilized by various stakeholders and further emphasizes calls to improve science communication so as to support balanced and informed decision-making. PMID:23402260

From cues to signals: evolution of interspecific communication via aposematism and mimicry in a predator-prey system.

PubMed

Lehmann, Kenna D S; Goldman, Brian W; Dworkin, Ian; Bryson, David M; Wagner, Aaron P

2014-01-01

Current theory suggests that many signaling systems evolved from preexisting cues. In aposematic systems, prey warning signals benefit both predator and prey. When the signal is highly beneficial, a third species often evolves to mimic the toxic species, exploiting the signaling system for its own protection. We investigated the evolutionary dynamics of predator cue utilization and prey signaling in a digital predator-prey system in which prey could evolve to alter their appearance to mimic poison-free or poisonous prey. In predators, we observed rapid evolution of cue recognition (i.e. active behavioral responses) when presented with sufficiently poisonous prey. In addition, active signaling (i.e. mimicry) evolved in prey under all conditions that led to cue utilization. Thus we show that despite imperfect and dishonest signaling, given a high cost of consuming poisonous prey, complex systems of interspecific communication can evolve via predator cue recognition and prey signal manipulation. This provides evidence supporting hypotheses that cues may serve as stepping-stones in the evolution of more advanced communication and signaling systems that incorporate information about the environment.

From Cues to Signals: Evolution of Interspecific Communication via Aposematism and Mimicry in a Predator-Prey System

PubMed Central

Lehmann, Kenna D. S.; Goldman, Brian W.; Dworkin, Ian; Bryson, David M.; Wagner, Aaron P.

2014-01-01

Current theory suggests that many signaling systems evolved from preexisting cues. In aposematic systems, prey warning signals benefit both predator and prey. When the signal is highly beneficial, a third species often evolves to mimic the toxic species, exploiting the signaling system for its own protection. We investigated the evolutionary dynamics of predator cue utilization and prey signaling in a digital predator-prey system in which prey could evolve to alter their appearance to mimic poison-free or poisonous prey. In predators, we observed rapid evolution of cue recognition (i.e. active behavioral responses) when presented with sufficiently poisonous prey. In addition, active signaling (i.e. mimicry) evolved in prey under all conditions that led to cue utilization. Thus we show that despite imperfect and dishonest signaling, given a high cost of consuming poisonous prey, complex systems of interspecific communication can evolve via predator cue recognition and prey signal manipulation. This provides evidence supporting hypotheses that cues may serve as stepping-stones in the evolution of more advanced communication and signaling systems that incorporate information about the environment. PMID:24614755

Diversifying selection in the wheat stem rust fungus acts predominantly on pathogen-associated gene families and reveals candidate effectors

PubMed Central

Sperschneider, Jana; Ying, Hua; Dodds, Peter N.; Gardiner, Donald M.; Upadhyaya, Narayana M.; Singh, Karam B.; Manners, John M.; Taylor, Jennifer M.

2014-01-01

Plant pathogens cause severe losses to crop plants and threaten global food production. One striking example is the wheat stem rust fungus, Puccinia graminis f. sp. tritici, which can rapidly evolve new virulent pathotypes in response to resistant host lines. Like several other filamentous fungal and oomycete plant pathogens, its genome features expanded gene families that have been implicated in host-pathogen interactions, possibly encoding effector proteins that interact directly with target host defense proteins. Previous efforts to understand virulence largely relied on the prediction of secreted, small and cysteine-rich proteins as candidate effectors and thus delivered an overwhelming number of candidates. Here, we implement an alternative analysis strategy that uses the signal of adaptive evolution as a line of evidence for effector function, combined with comparative information and expression data. We demonstrate that in planta up-regulated genes that are rapidly evolving are found almost exclusively in pathogen-associated gene families, affirming the impact of host-pathogen co-evolution on genome structure and the adaptive diversification of specialized gene families. In particular, we predict 42 effector candidates that are conserved only across pathogens, induced during infection and rapidly evolving. One of our top candidates has recently been shown to induce genotype-specific hypersensitive cell death in wheat. This shows that comparative genomics incorporating the evolutionary signal of adaptation is powerful for predicting effector candidates for laboratory verification. Our system can be applied to a wide range of pathogens and will give insight into host-pathogen dynamics, ultimately leading to progress in strategies for disease control. PMID:25225496

Using ICT to Teach "Hard to Teach" Topics in Science

ERIC Educational Resources Information Center

Oakes, Malcolm

2009-01-01

Science is a wonderful subject to teach. Often characterised as "hard", it is a subject that has evolved constantly over the years by adopting new practices. In recent years, these have included many aspects of ICT, which was the starting point for the author and his team's project. The basic principles of the project were that: (1) subject…

Reaching New Heights in Middle School Science: Straw Tower Competition Builds Student Interest

ERIC Educational Resources Information Center

Pliskow, Tia

2008-01-01

Science educators face the challenge of piquing students' interest in subjects whose concepts are often entirely foreign to them. The author wanted to give her students a hands-on, "real world" experience rooted in scientific concepts. What evolved was an engineering design competition. The point of the project was two-fold: to work on real-world…

Accelerators, Beams And Physical Review Special Topics - Accelerators And Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Siemann, R.H.; /SLAC

Accelerator science and technology have evolved as accelerators became larger and important to a broad range of science. Physical Review Special Topics - Accelerators and Beams was established to serve the accelerator community as a timely, widely circulated, international journal covering the full breadth of accelerators and beams. The history of the journal and the innovations associated with it are reviewed.

Rural/Urban Disparities in Science Achievement in Post-Socialist Countries: The Evolving Influence of Socioeconomic Status

ERIC Educational Resources Information Center

Kryst, Erica L.; Kotok, Stephen; Bodovski, Katerina

2015-01-01

Disparities in educational outcomes exist between students in rural areas as compared to students in urban settings. While there is some evidence that these rural disparities are present in eastern Europe, little is known about young peoples' lives in the rural areas of this region. This paper presents an analysis of science achievement by…

Girls and Science and Technology. Proceedings and Contributions of the GASAT Conference (4th, Ann Arbor, Michigan, July 24-29, 1987).

ERIC Educational Resources Information Center

Daniels, Jane Zimmer, Ed.; Kahle, Jane Butler, Ed.

In 1979, North European researchers met informally to discuss issues regarding women in science. In addition to discovering that the issues raised crossed national boundaries and cultural differences, they found that numerous efforts were underway to address their concerns. What started as an informal meeting has evolved today into an…

How To Solve Problems. For Success in Freshman Physics, Engineering, and Beyond. Third Edition.

ERIC Educational Resources Information Center

Scarl, Donald

To expertly solve engineering and science problems one needs to know science and engineering as well as have a tool kit of problem-solving methods. This book is about problem-solving methods: it presents the methods professional problem solvers use, explains why these methods have evolved, and shows how a student can make these methods his/her…

(abstract) The Evolving Spaceborne Radar Data Support to Earth Science and Operations at the Alaska SAR Facility

NASA Technical Reports Server (NTRS)

Carsey, Frank D.

1996-01-01

The Alaska SAR Facility (ASF) has been receiving, processing, archiving, and distributing data for Earth scientists and operations since it began receiving data in 1991. Four radar satellites are now being handled. Recent developments have served to increase the level of services of ASF to the Earth science community considerably. These developments are discussed.

The role of science in wilderness planning: a state-of-knowledge review

Treesearch

Edwin E. Krumpe

2000-01-01

Wilderness planning has evolved since the Wilderness Act of 1964 in an atmosphere of intense debate and public scrutiny. Wilderness planning and the role science has played in developing the planning process has been influenced by many complex legal mandates, by thorny social issues, and by emerging planning paradigms. Wilderness planning has at times been inspired by...

Self-Expression Assignment as a Teaching Approach to Enhance the Interest of Kuwaiti Women in Biological Sciences

ERIC Educational Resources Information Center

El-Sabban, Farouk

2008-01-01

Stimulating the interest of students in biological sciences necessitates the use of new teaching methods and motivating approaches. The idea of the self-expression assignment (SEA) has evolved from the prevalent environment at the College for Women of Kuwait University (Safat, State of Kuwait), a newly established college where the number of…

Pharmacovigilance and Biomedical Informatics: A Model for Future Development.

PubMed

Beninger, Paul; Ibara, Michael A

2016-12-01

The discipline of pharmacovigilance is rooted in the aftermath of the thalidomide tragedy of 1961. It has evolved as a result of collaborative efforts by many individuals and organizations, including physicians, patients, Health Authorities, universities, industry, the World Health Organization, the Council for International Organizations of Medical Sciences, and the International Conference on Harmonisation. Biomedical informatics is rooted in technologically based methodologies and has evolved at the speed of computer technology. The purpose of this review is to bring a novel lens to pharmacovigilance, looking at the evolution and development of the field of pharmacovigilance from the perspective of biomedical informatics, with the explicit goal of providing a foundation for discussion of the future direction of pharmacovigilance as a discipline. For this review, we searched [publication trend for the log 10 value of the numbers of publications identified in PubMed] using the key words [informatics (INF), pharmacovigilance (PV), phar-macovigilance þ informatics (PV þ INF)], for [study types] articles published between [1994-2015]. We manually searched the reference lists of identified articles for additional information. Biomedical informatics has made significant contributions to the infrastructural development of pharmacovigilance. However, there has not otherwise been a systematic assessment of the role of biomedical informatics in enhancing the field of pharmacovigilance, and there has been little cross-discipline scholarship. Rapidly developing innovations in biomedical informatics pose a challenge to pharmacovigilance in finding ways to include new sources of safety information, including social media, massively linked databases, and mobile and wearable wellness applications and sensors. With biomedical informatics as a lens, it is evident that certain aspects of pharmacovigilance are evolving more slowly. However, the high levels of mutual interest in both fields and intense global and economic external pressures offer opportunities for a future of closer collaboration. Copyright © 2016 Elsevier HS Journals, Inc. All rights reserved.

The Gulf of Mexico Coastal Ocean Observing System: A Gulf Science Portal

NASA Astrophysics Data System (ADS)

Howard, M.; Gayanilo, F.; Kobara, S.; Jochens, A. E.

2013-12-01

The Gulf of Mexico Coastal Ocean Observing System's (GCOOS) regional science portal (gcoos.org) was designed to aggregate data and model output from distributed providers and to offer these, and derived products, through a single access point in standardized ways to a diverse set of users. The portal evolved under the NOAA-led U.S. Integrated Ocean Observing System (IOOS) program where automated largely-unattended machine-to-machine interoperability has always been a guiding tenet for system design. The web portal has a business unit where membership lists, new items, and reference materials are kept, a data portal where near real-time and historical data are held and served, and a products portal where data are fused into products tailored for specific or general stakeholder groups. The staff includes a system architect who built and maintains the data portal, a GIS expert who built and maintains the current product portal, the executive director who marshals resources to keep news items fresh and data manger who manages most of this. The business portal is built using WordPress which was selected because it appeared to be the easiest content management system for non-web programmers to add content to, maintain and enhance. The data portal is custom built and uses database, PHP, and web services based on Open Geospatial Consortium standards-based Sensor Observation Service (SOS) with Observations and Measurements (O&M) encodings. We employ a standards-based vocabulary, which we helped develop, which is registered at the Marine Metadata Interoperability Ontology Registry and Repository (http://mmisw.org). The registry is currently maintained by one of the authors. Products appearing in the products portal are primarily constructed using ESRI software by a Ph.D. level Geographer. Some products were built with other software, generally by graduate students over the years. We have been sensitive to the private sector when deciding which products to produce. While science users want numbers, users of all types mainly want maps. We have tried to develop flexible capabilities to present products for a variety of output devices, from desktop screens to the smart phones. Software maintenance is a continuing issue and new initiatives from NOAA add to the work load but improve the system. We will discuss how our data management system has evolved within the backdrop of rapidly changing technologies and diverse community requirements.

Missed Opportunities: Origin, Growth, and Decline of Community College Fire Science Degree Programs in Alabama, 1977 to 2002

ERIC Educational Resources Information Center

Laughlin, Jerry W.

2007-01-01

There was rapid growth of Alabama community colleges in the late 1960s. At the same time, there was rapid growth nationally of fire science associate degree programs. With these concurrent events, one would expect fire department personnel in Alabama to benefit from new community college opportunities in fire science and fire administration.…

I Am a Pediatric Dentist: Why Is Substance Abuse among My Patients My Concern?

PubMed

Waldman, H Barry; Perlman, Steven P

The rapidly evolving demographic base of our communities intensifies the need for an awareness which in the past seemed beyond the traditional concerns of pediatric dentists; in this case, substance abuse by teenagers. A review was carried out regarding evolving demographics, the proportion of teenagers involved with substance abuse, the rationale for the use of varying elicit substances and the associated symptoms. A series of options for action are considered given the potential for pediatric dentists to be involved in the care of teenagers using elicit substances.

Does the rapid appearance of life on Earth suggest that life is common in the universe?

PubMed

Lineweaver, Charles H; Davis, Tamara M

2002-01-01

It is sometimes assumed that the rapidity of biogenesis on Earth suggests that life is common in the Universe. Here we critically examine the assumptions inherent in this if-life-evolved-rapidly-life-must-be-common argument. We use the observational constraints on the rapidity of biogenesis on Earth to infer the probability of biogenesis on terrestrial planets with the same unknown probability of biogenesis as the Earth. We find that on such planets, older than approximately 1 Gyr, the probability of biogenesis is > 13% at the 95% confidence level. This quantifies an important term in the Drake Equation but does not necessarily mean that life is common in the Universe.

Conference proceedings of the Northeast Autonomous Vehicle Summit.

DOT National Transportation Integrated Search

2017-05-24

The development of autonomous vehicle technology and potential adoption of autonomous vehicles is occurring at a rapid rate in the United States. As this technology evolves, there are many technical, logistical and legal issues that need to be addres...

Advanced Traveler Information Systems (ATIS) 2.0 Precursor System: Final Report

DOT National Transportation Integrated Search

2018-03-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

An evaluation of bridge deck joint sealing systems in Virginia.

DOT National Transportation Integrated Search

2003-01-01

The design and fabrication of bridge expansion joint (or movement) systems comprise a rapidly evolving industry. New designs are constantly being presented for trial, often on a piecemeal basis. Occasionally, failures of products occur without suffic...

Surface capillary currents: Rediscovery of fluid-structure interaction by forced evolving boundary theory

NASA Astrophysics Data System (ADS)

Wang, Chunbai; Mitra, Ambar K.

2016-01-01

Any boundary surface evolving in viscous fluid is driven with surface capillary currents. By step function defined for the fluid-structure interface, surface currents are found near a flat wall in a logarithmic form. The general flat-plate boundary layer is demonstrated through the interface kinematics. The dynamics analysis elucidates the relationship of the surface currents with the adhering region as well as the no-slip boundary condition. The wall skin friction coefficient, displacement thickness, and the logarithmic velocity-defect law of the smooth flat-plate boundary-layer flow are derived with the advent of the forced evolving boundary method. This fundamental theory has wide applications in applied science and engineering.

Report of the Community Review of EIC Accelerator R&D for the Office of Nuclear Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Nuclear Science Advisory Committee (NSAC) of the Department of Energy (DOE) Office of Nuclear Physics (NP) recommended in the 2015 Long Range Plan (LRP) for Nuclear Science that the proposed Electron Ion Collider (EIC) be the highest priority for new construction. This report noted that, at that time, two independent designs for such a facility had evolved in the United States, each of which proposed using infrastructure already available in the U.S. nuclear science community.

What Can Science Do for Me? Engaging Urban Teens in the Chandra Astrophysics Institute

NASA Astrophysics Data System (ADS)

Hartman, M.; Porro, I.; Baganoff, F.

2008-06-01

We present three years of longitudinal data showing how we can engage underrepresented high-school youth in out-of-school time research science. Over three years our participant population has evolved to be more reflective of the Boston student population as a result of changes in our recruitment strategy. In addition, changes in 4 major program areas helped all participant populations move toward our intended outcome of better understanding of the process of research science.

Science education in a secular age

NASA Astrophysics Data System (ADS)

Long, David E.

2013-03-01

A college science education instructor tells his students he rejects evolution. What should we think? The scene unfolds in one of the largest urban centers in the world. If we are surprised, why? Expanding on Federica Raia's (2012) first-hand experience with this scenario, I broaden her discussion by considering the complexity of science education in a secular age. Enjoining Raia within the framework of Charles Taylor's A Secular Age, I task the science education community to consider the broad strokes of science, religious faith, and the complexity of modernity in its evolving, hybridized forms. Building upon anthropological approaches to science education research, I articulate a framework to more fully account for who, globally, is a Creationist, and what this means for our views of ethically responsive science education.

Evaluating the Impact of Physical Activity Apps and Wearables: Interdisciplinary Review

PubMed Central

Rooksby, John; Gray, Cindy M

2018-01-01

Background Although many smartphone apps and wearables have been designed to improve physical activity, their rapidly evolving nature and complexity present challenges for evaluating their impact. Traditional methodologies, such as randomized controlled trials (RCTs), can be slow. To keep pace with rapid technological development, evaluations of mobile health technologies must be efficient. Rapid alternative research designs have been proposed, and efficient in-app data collection methods, including in-device sensors and device-generated logs, are available. Along with effectiveness, it is important to measure engagement (ie, users’ interaction and usage behavior) and acceptability (ie, users’ subjective perceptions and experiences) to help explain how and why apps and wearables work. Objectives This study aimed to (1) explore the extent to which evaluations of physical activity apps and wearables: employ rapid research designs; assess engagement, acceptability, as well as effectiveness; use efficient data collection methods; and (2) describe which dimensions of engagement and acceptability are assessed. Method An interdisciplinary scoping review using 8 databases from health and computing sciences. Included studies measured physical activity, and evaluated physical activity apps or wearables that provided sensor-based feedback. Results were analyzed using descriptive numerical summaries, chi-square testing, and qualitative thematic analysis. Results A total of 1829 abstracts were screened, and 858 articles read in full. Of 111 included studies, 61 (55.0%) were published between 2015 and 2017. Most (55.0%, 61/111) were RCTs, and only 2 studies (1.8%) used rapid research designs: 1 single-case design and 1 multiphase optimization strategy. Other research designs included 23 (22.5%) repeated measures designs, 11 (9.9%) nonrandomized group designs, 10 (9.0%) case studies, and 4 (3.6%) observational studies. Less than one-third of the studies (32.0%, 35/111) investigated effectiveness, engagement, and acceptability together. To measure physical activity, most studies (90.1%, 101/111) employed sensors (either in-device [67.6%, 75/111] or external [23.4%, 26/111]). RCTs were more likely to employ external sensors (accelerometers: P=.005). Studies that assessed engagement (52.3%, 58/111) mostly used device-generated logs (91%, 53/58) to measure the frequency, depth, and length of engagement. Studies that assessed acceptability (57.7%, 64/111) most often used questionnaires (64%, 42/64) and/or qualitative methods (53%, 34/64) to explore appreciation, perceived effectiveness and usefulness, satisfaction, intention to continue use, and social acceptability. Some studies (14.4%, 16/111) assessed dimensions more closely related to usability (ie, burden of sensor wear and use, interface complexity, and perceived technical performance). Conclusions The rapid increase of research into the impact of physical activity apps and wearables means that evaluation guidelines are urgently needed to promote efficiency through the use of rapid research designs, in-device sensors and user-logs to assess effectiveness, engagement, and acceptability. Screening articles was time-consuming because reporting across health and computing sciences lacked standardization. Reporting guidelines are therefore needed to facilitate the synthesis of evidence across disciplines. PMID:29572200

Evolution of a Teacher Professional Development Program that Promotes Teacher and Student Research

NASA Astrophysics Data System (ADS)

Pompea, S. M.; Croft, S. K.; Garmany, C. D.; Walker, C. E.

2005-12-01

The Research Based Science Education (RBSE) and Teacher Leaders in Research Based Science (TLRBSE) programs at the National Optical Astronomy Observatory have been evolving for nearly ten years. Our current program is actually a team of programs aiding teachers in doing research with small telescopes, large research-grade telescopes, astronomical data archives, and the Spitzer Space Telescope. Along the way, as these programs evolved, a number of basic questions were continuously discussed by the very talented program team. These questions included: 1) What is real research and why should we encourage it? 2) How can it be successfully brought to the classroom? 3) What is the relative importance of teacher content knowledge versus science process knowledge? 4) How frustrating should an authentic research experience be? 5) How do we measure the success of our professional development program? 6) How should be evaluate and publish student work? 7) How can teachers work together on a team to pursue research? 8) What is the model for interaction of teachers and researchers - equal partners versus the graduate student/apprentice model? 9) What is the ideal mix of skills for a professional development team at NOAO? 10) What role can distance learning play in professional preparation? 11) What tools are needed for data analysis? 12) How can we stay funded? Our evolving program has also been used as a test bed to examine new models of teacher's professional development that may aid our outreach efforts in the Large Synoptic Survey Telescope program, the Thirty-Meter Telescope program, and the National Virtual Observatory program. We will describe a variety of lessons learned (and relearned) and try to describe best practices in promoting teacher and student research. The TLRBSE Program is funded by the National Science Foundation under ESI 0101982, funded through the AURA/NSF Cooperative Agreement AST-9613615. NOAO is operated by the Association of Universities for Research in Astronomy (AURA), Inc. under cooperative agreement with the National Science Foundation.

Evaluation of research topic evolution in psychiatry using co-word analysis

PubMed Central

Wu, Ying; Jin, Xing; Xue, Yunzhen

2017-01-01

Abstract With the rapid increase in the incidence of mental disorders and mental issues, psychiatry has become one of the fastest growing clinical medical disciplines. Development priorities and research foci in this field have evolved over different periods. All the articles in 10 psychiatric journals with the highest impact factors were selected from the Science Citation Index (SCI) in Web of Science from 2001 to 2015. The information visualization software Sci2 was used to conduct co-word and clustering analyses on these articles. The articles were divided into 3 periods: 2001 to 2005, 2006 to 2010, and 2011 to 2015. Each bibliographic record contained a title, author names, abstract, keywords, references, and other information. During the 3 periods between 2001 and 2015, child and adolescent psychiatry, major depression, schizophrenia, and prefrontal cortex were constant research foci. The brain and meta-analysis gradually became new research foci, although research on symptoms slowly decreased. Molecular genetics was also an area of interest. Using scientometrics technology to visualize research foci can provide us with new ideas and research methods. Co-word analysis for the preliminary exploration of research foci and developmental trends in psychiatry is helpful in finding developmental rules, choices of topics, and innovative research. Our study had some limitations. In the future, we should expand our research scope and use a variety of research methods to enrich our results. PMID:28640150

Evolution of food provision to athletes at the summer Olympic Games.

PubMed

Pelly, Fiona E; O'Connor, Helen T; Denyer, Gareth S; Caterson, Ian D

2011-06-01

The history of food provision at the summer Olympic Games (OG) over the past century (1896-2008) provides insight into the evolution of sports nutrition research and the dietary strategies of athletes. Early research favoring protein as the main fuel for exercise was reflected in OG menus from 1932 to 1968. Despite conclusive research from the 1960s demonstrating the clear benefit of carbohydrate on exercise performance, a specific emphasis on carbohydrate-rich foods was not noted until the 1970s. Athlete food preferences and catering complexity evolved rapidly between 1970 and 2000, driven predominantly by a dramatic expansion of the OG and the emergence of systematic sports nutrition research. Nutritional advice by experts and sponsorship by food companies became increasingly important beginning with the 1984 Los Angeles OG. More recent developments include nutritional labeling of menu items and provision of a nutrition information desk (Barcelona 1992), demand for a "high-starch, low-fat menu" (Atlanta 1996), the addition of a dedicated menu website and the systematic gathering of information on athletes' apparent consumption (Sydney 2000), and appointment of the first international dietetic review committee (Beijing 2008). The history of catering at the OG tracks the evolution of sports nutrition practice from anecdotes and myth towards an established specialty in nutrition and dietetics grounded in evidence-based science. © 2011 International Life Sciences Institute.

Evaluation of research topic evolution in psychiatry using co-word analysis.

PubMed

Wu, Ying; Jin, Xing; Xue, Yunzhen

2017-06-01

With the rapid increase in the incidence of mental disorders and mental issues, psychiatry has become one of the fastest growing clinical medical disciplines. Development priorities and research foci in this field have evolved over different periods.All the articles in 10 psychiatric journals with the highest impact factors were selected from the Science Citation Index (SCI) in Web of Science from 2001 to 2015. The information visualization software Sci was used to conduct co-word and clustering analyses on these articles. The articles were divided into 3 periods: 2001 to 2005, 2006 to 2010, and 2011 to 2015. Each bibliographic record contained a title, author names, abstract, keywords, references, and other information.During the 3 periods between 2001 and 2015, child and adolescent psychiatry, major depression, schizophrenia, and prefrontal cortex were constant research foci. The brain and meta-analysis gradually became new research foci, although research on symptoms slowly decreased. Molecular genetics was also an area of interest.Using scientometrics technology to visualize research foci can provide us with new ideas and research methods. Co-word analysis for the preliminary exploration of research foci and developmental trends in psychiatry is helpful in finding developmental rules, choices of topics, and innovative research. Our study had some limitations. In the future, we should expand our research scope and use a variety of research methods to enrich our results.

White paper on science operations

NASA Technical Reports Server (NTRS)

Schreier, Ethan J.

1991-01-01

Major changes are taking place in the way astronomy gets done. There are continuing advances in observational capabilities across the frequency spectrum, involving both ground-based and space-based facilities. There is also very rapid evolution of relevant computing and data management technologies. However, although the new technologies are filtering in to the astronomy community, and astronomers are looking at their computing needs in new ways, there is little coordination or coherent policy. Furthermore, although there is great awareness of the evolving technologies in the arena of operations, much of the existing operations infrastructure is ill-suited to take advantage of them. Astronomy, especially space astronomy, has often been at the cutting edge of computer use in data reduction and image analysis, but has been somewhat removed from advanced applications in operations, which have tended to be implemented by industry rather than by the end-user scientists. The purpose of this paper is threefold. First, we briefly review the background and general status of astronomy-related computing. Second, we make recommendations in three areas: data analysis; operations (directed primarily to NASA-related activities); and issues of management and policy, believing that these must be addressed to enable technological progress and to proceed through the next decade. Finally, we recommend specific NASA-related work as part of the Astrotech-21 plans, to enable better science operations in the operations of the Great Observatories and in the lunar outpost era.

Mixed Reality Meets Pharmaceutical Development.

PubMed

Forrest, William P; Mackey, Megan A; Shah, Vivek M; Hassell, Kerry M; Shah, Prashant; Wylie, Jennifer L; Gopinath, Janakiraman; Balderhaar, Henning; Li, Li; Wuelfing, W Peter; Helmy, Roy

2017-12-01

As science evolves, the need for more efficient and innovative knowledge transfer capabilities becomes evident. Advances in drug discovery and delivery sciences have directly impacted the pharmaceutical industry, though the added complexities have not shortened the development process. These added complexities also make it difficult for scientists to rapidly and effectively transfer knowledge to offset the lengthened drug development timelines. While webcams, camera phones, and iPads have been explored as potential new methods of real-time information sharing, the non-"hands-free" nature and lack of viewer and observer point-of-view render them unsuitable for the R&D laboratory or manufacturing setting. As an alternative solution, the Microsoft HoloLens mixed-reality headset was evaluated as a more efficient, hands-free method of knowledge transfer and information sharing. After completing a traditional method transfer between 3 R&D sites (Rahway, NJ; West Point, PA and Schnachen, Switzerland), a retrospective analysis of efficiency gain was performed through the comparison of a mock method transfer between NJ and PA sites using the HoloLens. The results demonstrated a minimum 10-fold gain in efficiency, weighing in from a savings in time, cost, and the ability to have real-time data analysis and discussion. In addition, other use cases were evaluated involving vendor and contract research/manufacturing organizations. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

The medical decision model and decision maker tools for management of radiological and nuclear incidents.

PubMed

Koerner, John F; Coleman, C Norman; Murrain-Hill, Paula; FitzGerald, Denis J; Sullivan, Julie M

2014-06-01

Effective decision making during a rapidly evolving emergency such as a radiological or nuclear incident requires timely interim decisions and communications from onsite decision makers while further data processing, consultation, and review are ongoing by reachback experts. The authors have recently proposed a medical decision model for use during a radiological or nuclear disaster, which is similar in concept to that used in medical care, especially when delay in action can have disastrous effects. For decision makers to function most effectively during a complex response, they require access to onsite subject matter experts who can provide information, recommendations, and participate in public communication efforts. However, in the time before this expertise is available or during the planning phase, just-in-time tools are essential that provide critical overview of the subject matter written specifically for the decision makers. Recognizing the complexity of the science, risk assessment, and multitude of potential response assets that will be required after a nuclear incident, the Office of the Assistant Secretary for Preparedness and Response, in collaboration with other government and non-government experts, has prepared a practical guide for decision makers. This paper illustrates how the medical decision model process could facilitate onsite decision making that includes using the deliberative reachback process from science and policy experts and describes the tools now available to facilitate timely and effective incident management.

Advances in the NASA Earth Science Division Applied Science Program

NASA Astrophysics Data System (ADS)

Friedl, L.; Bonniksen, C. K.; Escobar, V. M.

2016-12-01

The NASA Earth Science Division's Applied Science Program advances the understanding of and ability to used remote sensing data in support of socio-economic needs. The integration of socio-economic considerations in to NASA Earth Science projects has advanced significantly. The large variety of acquisition methods used has required innovative implementation options. The integration of application themes and the implementation of application science activities in flight project is continuing to evolve. The creation of the recently released Earth Science Division, Directive on Project Applications Program and the addition of an application science requirement in the recent EVM-2 solicitation document NASA's current intent. Continuing improvement in the Earth Science Applications Science Program are expected in the areas of thematic integration, Project Applications Program tailoring for Class D missions and transfer of knowledge between scientists and projects.

Telecommunications for Mars Rovers and Robotic Mission

NASA Technical Reports Server (NTRS)

Horne, W. D.; Hastrup, R.; Cesarone, R.

1997-01-01

The Mars exploration program of NASA and the international community will evolve from an early emphasis on orbital remote sensing toward in-situ science activity on, or just above, the Martian surface.

Telecommunications for Mars Rovers and Robotic Missions

NASA Technical Reports Server (NTRS)

Horne, W. D.; Hastrup, R.; Cesarone, R.

1997-01-01

The Mars exploration program of NASA and the international community will evolve from an early emphasis on orbital remote sensing toward in situ science activity on, or just above, the Martian surface.

Fort Collins Science Center-Fiscal year 2009 science accomplishments

USGS Publications Warehouse

Wilson, Juliette T.

2010-01-01

Public land and natural resource managers in the United States are confronted with increasingly complex decisions that have important ramifications for both ecological and human systems. The scientists and technical professionals at the U.S. Geological Survey Fort Collins Science Center?many of whom are at the forefront of their fields?possess a unique blend of ecological, socioeconomic, and technological expertise. Because of this diverse talent, Fort Collins Science Center staff are able to apply a systems approach to investigating complicated ecological problems in a way that helps answer critical management questions. In addition, the Fort Collins Science Center has a long record of working closely with the academic community through cooperative agreements and other collaborations. The Fort Collins Science Center is deeply engaged with other U.S. Geological Survey science centers and partners throughout the Department of the Interior. As a regular practice, we incorporate the expertise of these partners in providing a full complement of ?the right people? to effectively tackle the multifaceted research problems of today's resource-management world. In Fiscal Year 2009, the Fort Collins Science Center's scientific and technical professionals continued research vital to Department of the Interior's science and management needs. Fort Collins Science Center work also supported the science needs of other Federal and State agencies as well as non-government organizations. Specifically, Fort Collins Science Center research and technical assistance focused on client and partner needs and goals in the areas of biological information management and delivery, enterprise information, fisheries and aquatic systems, invasive species, status and trends of biological resources (including human dimensions), terrestrial ecosystems, and wildlife resources. In the process, Fort Collins Science Center science addressed natural-science information needs identified in the U.S. Geological Survey Science Strategy (http://www.usgs.gov/science_strategy), including understanding and predicting change in ecosystems, climate variability and change, energy development and land management, the role of the environment and wildlife in human health, freshwater ecosystems, data integration, and evolving technologies. Several science projects were expanded in Fiscal Year 2009 to meet these evolving needs.

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

PubMed

Emens, Leisha A; Ascierto, Paolo A; Darcy, Phillip K; Demaria, Sandra; Eggermont, Alexander M M; Redmond, William L; Seliger, Barbara; Marincola, Francesco M

2017-08-01

Cancer immunotherapy is now established as a powerful way to treat cancer. The recent clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) highlights both the universal power of treating the immune system across tumour types and the unique features of cancer immunotherapy. Immune-related adverse events, atypical clinical response patterns, durable responses, and clear overall survival benefit distinguish cancer immunotherapy from cytotoxic cancer therapy. Combination immunotherapies that transform non-responders to responders are under rapid development. Current challenges facing the field include incorporating immunotherapy into adjuvant and neoadjuvant cancer therapy, refining dose, schedule and duration of treatment and developing novel surrogate endpoints that accurately capture overall survival benefit early in treatment. As the field rapidly evolves, we must prioritise the development of biomarkers to guide the use of immunotherapies in the most appropriate patients. Immunotherapy is already transforming cancer from a death sentence to a chronic disease for some patients. By making smart, evidence-based decisions in developing next generation immunotherapies, cancer should become an imminently treatable, curable and even preventable disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Genome Biology of Effector Gene Evolution in Filamentous Plant Pathogens.

PubMed

Sánchez-Vallet, Andrea; Fouché, Simone; Fudal, Isabelle; Hartmann, Fanny E; Soyer, Jessica L; Tellier, Aurélien; Croll, Daniel

2018-05-16

Filamentous pathogens, including fungi and oomycetes, pose major threats to global food security. Crop pathogens cause damage by secreting effectors that manipulate the host to the pathogen's advantage. Genes encoding such effectors are among the most rapidly evolving genes in pathogen genomes. Here, we review how the major characteristics of the emergence, function, and regulation of effector genes are tightly linked to the genomic compartments where these genes are located in pathogen genomes. The presence of repetitive elements in these compartments is associated with elevated rates of point mutations and sequence rearrangements with a major impact on effector diversification. The expression of many effectors converges on an epigenetic control mediated by the presence of repetitive elements. Population genomics analyses showed that rapidly evolving pathogens show high rates of turnover at effector loci and display a mosaic in effector presence-absence polymorphism among strains. We conclude that effective pathogen containment strategies require a thorough understanding of the effector genome biology and the pathogen's potential for rapid adaptation. Expected final online publication date for the Annual Review of Phytopathology Volume 56 is August 25, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Sexual selection and the evolution of secondary sexual traits: sex comb evolution in Drosophila.

PubMed

Snook, Rhonda R; Gidaszewski, Nelly A; Chapman, Tracey; Simmons, Leigh W

2013-04-01

Sexual selection can drive rapid evolutionary change in reproductive behaviour, morphology and physiology. This often leads to the evolution of sexual dimorphism, and continued exaggerated expression of dimorphic sexual characteristics, although a variety of other alternative selection scenarios exist. Here, we examined the evolutionary significance of a rapidly evolving, sexually dimorphic trait, sex comb tooth number, in two Drosophila species. The presence of the sex comb in both D. melanogaster and D. pseudoobscura is known to be positively related to mating success, although little is yet known about the sexually selected benefits of sex comb structure. In this study, we used experimental evolution to test the idea that enhancing or eliminating sexual selection would lead to variation in sex comb tooth number. However, the results showed no effect of either enforced monogamy or elevated promiscuity on this trait. We discuss several hypotheses to explain the lack of divergence, focussing on sexually antagonistic coevolution, stabilizing selection via species recognition and nonlinear selection. We discuss how these are important, but relatively ignored, alternatives in understanding the evolution of rapidly evolving sexually dimorphic traits. © 2013 The Authors. Journal of Evolutionary Biology © 2013 European Society For Evolutionary Biology.

Thermal Control Technologies for Complex Spacecraft

NASA Technical Reports Server (NTRS)

Swanson, Theodore D.

2004-01-01

Thermal control is a generic need for all spacecraft. In response to ever more demanding science and exploration requirements, spacecraft are becoming ever more complex, and hence their thermal control systems must evolve. This paper briefly discusses the process of technology development, the state-of-the-art in thermal control, recent experiences with on-orbit two-phase systems, and the emerging thermal control technologies to meet these evolving needs. Some "lessons learned" based on experience with on-orbit systems are also presented.

The oldest records of photosynthesis

NASA Technical Reports Server (NTRS)

Awramik, S. M.

1992-01-01

There is diverse, yet controversial fossil evidence for the existence of photosynthesis 3500 million years ago. Among the most persuasive evidence is the stromatolites described from low grade metasedimentary rocks in Western Australia and South Africa. Based on the understanding of the paleobiology of stromatolites and using pertinent fossil and Recent analogs, these Early Archean stromatolites suggest that phototrophs evolved by 3500 million years ago. The evidence allows further interpretation that cyanobacteria were involved. Besides stromatolites, microbial and chemical fossils are also known from the same rock units. Some microfossils morphologically resemble cyanobacteria and thus complement the adduced cyanobacterial involvement in stromatolite construction. If cyanobacteria had evolved by 3500 million years ago, this would indicate that nearly all prokaryotic phyla had already evolved and that prokaryotes diversified rapidly on the early Earth.

Extinction Events Can Accelerate Evolution

PubMed Central

Lehman, Joel; Miikkulainen, Risto

2015-01-01

Extinction events impact the trajectory of biological evolution significantly. They are often viewed as upheavals to the evolutionary process. In contrast, this paper supports the hypothesis that although they are unpredictably destructive, extinction events may in the long term accelerate evolution by increasing evolvability. In particular, if extinction events extinguish indiscriminately many ways of life, indirectly they may select for the ability to expand rapidly through vacated niches. Lineages with such an ability are more likely to persist through multiple extinctions. Lending computational support for this hypothesis, this paper shows how increased evolvability will result from simulated extinction events in two computational models of evolved behavior. The conclusion is that although they are destructive in the short term, extinction events may make evolution more prolific in the long term. PMID:26266804

Virus Satellites Drive Viral Evolution and Ecology

PubMed Central

Frígols, Belén; Quiles-Puchalt, Nuria; Mir-Sanchis, Ignacio; Donderis, Jorge; Elena, Santiago F.; Buckling, Angus; Novick, Richard P.; Marina, Alberto; Penadés, José R.

2015-01-01

Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However, the evolutionary and ecological implications of satellites on helper viruses remain unclear. Here, using staphylococcal pathogenicity islands (SaPIs) as a model of virus satellites, we experimentally show that helper viruses rapidly evolve resistance to their virus satellites, preventing SaPI proliferation, and SaPIs in turn can readily evolve to overcome phage resistance. Genomic analyses of both these experimentally evolved strains as well as naturally occurring bacteriophages suggest that the SaPIs drive the coexistence of multiple alleles of the phage-coded SaPI inducing genes, as well as sometimes selecting for the absence of the SaPI depressing genes. We report similar (accidental) evolution of resistance to SaPIs in laboratory phages used for Staphylococcus aureus typing and also obtain the same qualitative results in both experimental evolution and phylogenetic studies of Enterococcus faecalis phages and their satellites viruses. In summary, our results suggest that helper and satellite viruses undergo rapid coevolution, which is likely to play a key role in the evolution and ecology of the viruses as well as their prokaryotic hosts. PMID:26495848

Rapid Sequencing of Complete env Genes from Primary HIV-1 Samples.

PubMed

Laird Smith, Melissa; Murrell, Ben; Eren, Kemal; Ignacio, Caroline; Landais, Elise; Weaver, Steven; Phung, Pham; Ludka, Colleen; Hepler, Lance; Caballero, Gemma; Pollner, Tristan; Guo, Yan; Richman, Douglas; Poignard, Pascal; Paxinos, Ellen E; Kosakovsky Pond, Sergei L; Smith, Davey M

2016-07-01

The ability to study rapidly evolving viral populations has been constrained by the read length of next-generation sequencing approaches and the sampling depth of single-genome amplification methods. Here, we develop and characterize a method using Pacific Biosciences' Single Molecule, Real-Time (SMRT®) sequencing technology to sequence multiple, intact full-length human immunodeficiency virus-1 env genes amplified from viral RNA populations circulating in blood, and provide computational tools for analyzing and visualizing these data.

76 FR 63567 - Internet Communication Disclaimers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... rapidly evolving technological innovations, while ensuring that `necessary precautions' are in place... technological innovations * * * where the use of the technology would not compromise the intent of the Act or... disclaimer requirements in light of technological developments in Internet advertising. The Commission is now...

MDOT innovation leading to faster, longer-lasting pavement repairs : research spotlight.

DOT National Transportation Integrated Search

2015-01-01

Current methods of patching pavement must evolve to meet increasing mobility demands. : To address this need, MDOT has been testing a new generation of rapid set full-depth : pavement repair materials. Initial results are promising. The new materials...

Rates of ecological divergence and body size evolution are correlated with species diversification in scaly tree ferns

PubMed Central

Ramírez-Barahona, Santiago; Barrera-Redondo, Josué; Eguiarte, Luis E.

2016-01-01

Variation in species richness across regions and between different groups of organisms is a major feature of evolution. Several factors have been proposed to explain these differences, including heterogeneity in the rates of species diversification and the age of clades. It has been frequently assumed that rapid rates of diversification are coupled to high rates of ecological and morphological evolution, leading to a prediction that remains poorly explored for most species: the positive association between ecological niche divergence, morphological evolution and species diversification. We combined a time-calibrated phylogeny with distribution, ecological and body size data for scaly tree ferns (Cyatheaceae) to test whether rates of species diversification are predicted by the rates at which clades have evolved distinct ecological niches and body sizes. We found that rates of species diversification are positively correlated with rates of ecological and morphological evolution, with rapidly diversifying clades also showing rapidly evolving ecological niches and body sizes. Our results show that rapid diversification of scaly tree ferns is associated with the evolution of species with comparable morphologies that diversified into similar, yet distinct, environments. This suggests parallel evolutionary pathways opening in different tropical regions whenever ecological and geographical opportunities arise. Accordingly, rates of ecological niche and body size evolution are relevant to explain the current patterns of species richness in this ‘ancient’ fern lineage across the tropics. PMID:27412279

The evolution and ascent paths of mantle xenolith-bearing magma: Observations and insights from Cenozoic basalts in Southeast China

NASA Astrophysics Data System (ADS)

Sun, Pu; Niu, Yaoling; Guo, Pengyuan; Cui, Huixia; Ye, Lei; Liu, Jinju

2018-06-01

Studies have shown that mantle xenolith-bearing magmas must ascend rapidly to carry mantle xenoliths to the surface. It has thus been inferred inadvertently that such rapid ascending melt must have undergone little crystallization or evolution. However, this inference is apparently inconsistent with the widespread observation that xenolith-bearing alkali basalts are variably evolved with Mg# ≤72. In this paper, we discuss this important, yet overlooked, petrological problem and offer new perspectives with evidence. We analyzed the Cenozoic mantle xenolith-bearing alkali basalts from several locations in Southeast China that have experienced varying degrees of fractional crystallization (Mg# = 48-67). The variably evolved composition of host alkali basalts is not in contradiction with rapid ascent, but rather reflects inevitability of crystallization during ascent. Thermometry calculations for clinopyroxene (Cpx) megacrysts give equilibrium temperatures of 1238-1390 °C, which is consistent with the effect of conductive cooling and melt crystallization during ascent because TMelt > TLithosphere. The equilibrium pressure (18-27 kbar) of these Cpx megacrysts suggests that the crystallization takes place under lithospheric mantle conditions. The host melt must have experienced limited low-pressure residence in the shallower levels of lithospheric mantle and crust. This is in fact consistent with the rapid ascent of the host melt to bring mantle xenoliths to the surface.

iPTF 16asu: A Luminous, Rapidly Evolving, and High-velocity Supernova

DOE PAGES

Whitesides, L.; Lunnan, R.; Kasliwal, M. M.; ...

2017-12-18

Wide-field surveys are discovering a growing number of rare transients whose physical origin is not yet well understood. We present optical and UV data and analysis of intermediate Palomar Transient Factory (iPTF) 16asu, a luminous, rapidly evolving, high-velocity, stripped-envelope supernova (SN). With a rest-frame rise time of just four days and a peak absolute magnitude of M g = -20.4 mag, the light curve of iPTF 16asu is faster and more luminous than that of previous rapid transients. The spectra of iPTF 16asu show a featureless blue continuum near peak that develops into an SN Ic-BL spectrum on the decline.more » We show that while the late-time light curve could plausibly be powered by 56Ni decay, the early emission requires a different energy source. Nondetections in the X-ray and radio strongly constrain the energy coupled to relativistic ejecta to be at most comparable to the class of low-luminosity gamma-ray bursts (GRBs). We suggest that the early emission may have been powered by either a rapidly spinning-down magnetar or by shock breakout in an extended envelope of a very energetic explosion. In either scenario a central engine is required, making iPTF 16asu an intriguing transition object between superluminous SNe, SNe Ic-BL, and low-luminosity GRBs.« less

Rates of ecological divergence and body size evolution are correlated with species diversification in scaly tree ferns.

PubMed

Ramírez-Barahona, Santiago; Barrera-Redondo, Josué; Eguiarte, Luis E

2016-07-13

Variation in species richness across regions and between different groups of organisms is a major feature of evolution. Several factors have been proposed to explain these differences, including heterogeneity in the rates of species diversification and the age of clades. It has been frequently assumed that rapid rates of diversification are coupled to high rates of ecological and morphological evolution, leading to a prediction that remains poorly explored for most species: the positive association between ecological niche divergence, morphological evolution and species diversification. We combined a time-calibrated phylogeny with distribution, ecological and body size data for scaly tree ferns (Cyatheaceae) to test whether rates of species diversification are predicted by the rates at which clades have evolved distinct ecological niches and body sizes. We found that rates of species diversification are positively correlated with rates of ecological and morphological evolution, with rapidly diversifying clades also showing rapidly evolving ecological niches and body sizes. Our results show that rapid diversification of scaly tree ferns is associated with the evolution of species with comparable morphologies that diversified into similar, yet distinct, environments. This suggests parallel evolutionary pathways opening in different tropical regions whenever ecological and geographical opportunities arise. Accordingly, rates of ecological niche and body size evolution are relevant to explain the current patterns of species richness in this 'ancient' fern lineage across the tropics. © 2016 The Author(s).

Spatiotemporal reconstruction of the Aquilegia rapid radiation through next-generation sequencing of rapidly evolving cpDNA regions.

PubMed

Fior, Simone; Li, Mingai; Oxelman, Bengt; Viola, Roberto; Hodges, Scott A; Ometto, Lino; Varotto, Claudio

2013-04-01

Aquilegia is a well-known model system in the field of evolutionary biology, but obtaining a resolved and well-supported phylogenetic reconstruction for the genus has been hindered by its recent and rapid diversification. Here, we applied 454 next-generation sequencing to PCR amplicons of 21 of the most rapidly evolving regions of the plastome to generate c. 24 kb of sequences from each of 84 individuals from throughout the genus. The resulting phylogeny has well-supported resolution of the main lineages of the genus, although recent diversification such as in the European taxa remains unresolved. By producing a chronogram of the whole Ranunculaceae family based on published data, we inferred calibration points for dating the Aquilegia radiation. The genus originated in the upper Miocene c. 6.9 million yr ago (Ma) in Eastern Asia, and diversification occurred c. 4.8 Ma with the split of two main clades, one colonizing North America, and the other Western Eurasia through the mountains of Central Asia. This was followed by a back-to-Asia migration, originating from the European stock using a North Asian route. These results provide the first backbone phylogeny and spatiotemporal reconstruction of the Aquilegia radiation, and constitute a robust framework to address the adaptative nature of speciation within the group. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.