Respiratory distress syndrome in preterm infants and risk of epilepsy in a Danish cohort.

PubMed

Thygesen, Sandra Kruchov; Olsen, Morten; Pedersen, Lars; Henderson, Victor W; Østergaard, John Rosendahl; Sørensen, Henrik Toft

2018-03-01

Infant respiratory distress syndrome (IRDS) may be complicated by intracerebral hemorrhage, a known trigger of epilepsy. However, few data exist on long term epilepsy risk following IRDS. We therefore examined the association between IRDS in preterm infants and childhood epilepsy. We conducted a population-based cohort study using individual-level data linkage among nationwide registries. All infants born at 32-36 weeks of gestation in 1978-2009 were identified in the Medical Birth Registry. We identified children with IRDS and those with epilepsy using the Danish National Patient Registry. We computed the cumulative incidence of epilepsy with follow-up from birth until epilepsy, emigration, death, age 15, or December 31, 2014. We used Cox's regression analysis to compute hazard ratios comparing children with and without IRDS, adjusting for sex, birth year, gestational age, multiplicity, major malformations, and maternal age. We identified 95,026 infants, of whom 6426 (6.8%) had IRDS. The cumulative incidence of epilepsy was 3.4% by age 15 in children with IRDS and 2.1% in children without IRDS. The adjusted hazard ratio of epilepsy among children with IRDS compared to those without was 1.4 (95% CI 1.2-1.6). When we restricted the IRDS cohort to children with no simultaneous morbidities that had clinical symptoms overlapping with IRDS, the overall adjusted HR was 1.1 (95% CI 0.9-1.4). In children born preterm at 32-36 weeks' gestation, IRDS was associated with increased risk of childhood epilepsy.

Whole Genome Sequencing Increases Molecular Diagnostic Yield Compared with Current Diagnostic Testing for Inherited Retinal Disease.

PubMed

Ellingford, Jamie M; Barton, Stephanie; Bhaskar, Sanjeev; Williams, Simon G; Sergouniotis, Panagiotis I; O'Sullivan, James; Lamb, Janine A; Perveen, Rahat; Hall, Georgina; Newman, William G; Bishop, Paul N; Roberts, Stephen A; Leach, Rick; Tearle, Rick; Bayliss, Stuart; Ramsden, Simon C; Nemeth, Andrea H; Black, Graeme C M

2016-05-01

To compare the efficacy of whole genome sequencing (WGS) with targeted next-generation sequencing (NGS) in the diagnosis of inherited retinal disease (IRD). Case series. A total of 562 patients diagnosed with IRD. We performed a direct comparative analysis of current molecular diagnostics with WGS. We retrospectively reviewed the findings from a diagnostic NGS DNA test for 562 patients with IRD. A subset of 46 of 562 patients (encompassing potential clinical outcomes of diagnostic analysis) also underwent WGS, and we compared mutation detection rates and molecular diagnostic yields. In addition, we compared the sensitivity and specificity of the 2 techniques to identify known single nucleotide variants (SNVs) using 6 control samples with publically available genotype data. Diagnostic yield of genomic testing. Across known disease-causing genes, targeted NGS and WGS achieved similar levels of sensitivity and specificity for SNV detection. However, WGS also identified 14 clinically relevant genetic variants through WGS that had not been identified by NGS diagnostic testing for the 46 individuals with IRD. These variants included large deletions and variants in noncoding regions of the genome. Identification of these variants confirmed a molecular diagnosis of IRD for 11 of the 33 individuals referred for WGS who had not obtained a molecular diagnosis through targeted NGS testing. Weighted estimates, accounting for population structure, suggest that WGS methods could result in an overall 29% (95% confidence interval, 15-45) uplift in diagnostic yield. We show that WGS methods can detect disease-causing genetic variants missed by current NGS diagnostic methodologies for IRD and thereby demonstrate the clinical utility and additional value of WGS. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility

PubMed Central

Schmid, Martin R.; Anderl, Ines; Vo, Hoa T. M.; Valanne, Susanna; Yang, Hairu; Kronhamn, Jesper; Rämet, Mika; Rusten, Tor Erik

2016-01-01

To understand how Toll signaling controls the activation of a cellular immune response in Drosophila blood cells (hemocytes), we carried out a genetic modifier screen, looking for deletions that suppress or enhance the mobilization of sessile hemocytes by the gain-of-function mutation Toll10b (Tl10b). Here we describe the results from chromosome arm 3R, where five regions strongly suppressed this phenotype. We identified the specific genes immune response deficient 1 (ird1), headcase (hdc) and possibly Rab23 as suppressors, and we studied the role of ird1 in more detail. An ird1 null mutant and a mutant that truncates the N-terminal kinase domain of the encoded Ird1 protein affected the Tl10b phenotype, unlike mutations that affect the C-terminal part of the protein. The ird1 null mutant suppressed mobilization of sessile hemocytes, but enhanced other Tl10b hemocyte phenotypes, like the formation of melanotic nodules and the increased number of circulating hemocytes. ird1 mutants also had blood cell phenotypes on their own. They lacked crystal cells and showed aberrant formation of lamellocytes. ird1 mutant plasmatocytes had a reduced ability to spread on an artificial substrate by forming protrusions, which may explain why they did not go into circulation in response to Toll signaling. The effect of the ird1 mutation depended mainly on ird1 expression in hemocytes, but ird1-dependent effects in other tissues may contribute. Specifically, the Toll receptor was translocated from the cell membrane to intracellular vesicles in the fat body of the ird1 mutant, and Toll signaling was activated in that tissue, partially explaining the Tl10b-like phenotype. As ird1 is otherwise known to control vesicular transport, we conclude that the vesicular transport system may be of particular importance during an immune response. PMID:27467079

Novel Proxies Approach to Characterise Ice Rafting Events in the North Atlantic

NASA Astrophysics Data System (ADS)

Kornilova, O.; Russell, M.; Rosell-Melé, A.; Evans, I. S.

2002-12-01

During the last glacial period, there have been several episodes of quasi-periodic iceberg discharge from the ice sheets into the North Atlantic (Heinrich Events) (Heinrich, 1988). These episodes are recorded in Quaternary sediments as layers of ice rafted debris (IRD). Properties of sediments in these Heinrich Layers (HLs) differ from those of adjacent ambient sediments. Heinrich Events (HEs) are associated with changes in global climate. To determine the cause of HEs, work on provenance of IRD was undertaken. Previous studies included analysis of bulk properties of lithic and organic matter in IRD and an attempt to correlate them with those of possible continental sources (e.g. Grousset et al., 2001). We used biomarker approach to characterise the provenance of IRD in the North Atlantic, similar to oil-source rock correlation used in petroleum industry. In this work, biomarker composition of Heinrich Layers from several North Atlantic cores was compared with that of possible source areas. As a proxy for source of IRD, we analysed glaciogenic debris flows from trough mouth fans (TMF) that formed as a result of iceberg discharge (Vorren and Laberg, 1997). Those included samples from the Nordic Seas, Labrador Sea and Baffin Bay. Different classes of organic compounds (e.g. photosynthetic pigments and hydrocarbons) were characterised. Variability within each class, relative abundances of different components and isotopic signatures were considered. Biomarker fingerprints were compared within each core, within each TMF and between TMFs. Cluster analysis was performed to correlate sources of IRD (TMFs) and its sinks (HLs from several North Atlantic cores). Grousset et al. 2001. Zooming in on Heinrich layers. Paleoceanography, 16, 240-259. Heinrich, H. 1988. Origin and Consequence of Ice Rafting In Northeast Atlantic Ocean During the Past 130,000 Years. Quaternary Research, 29, 143-152. Vorren and Laberg. 1997. Trough Mouth Fans - Palaeoclimate and Ice-Sheet Monitors. Quaternary Science Reviews, 16, 856-881.

Effect of a Mobile Web App on Kidney Transplant Candidates' Knowledge About Increased Risk Donor Kidneys: A Randomized Controlled Trial.

PubMed

Gordon, Elisa J; Sohn, Min-Woong; Chang, Chih-Hung; McNatt, Gwen; Vera, Karina; Beauvais, Nicole; Warren, Emily; Mannon, Roslyn B; Ison, Michael G

2017-06-01

Kidney transplant candidates (KTCs) must provide informed consent to accept kidneys from increased risk donors (IRD), but poorly understand them. We conducted a multisite, randomized controlled trial to evaluate the efficacy of a mobile Web application, Inform Me, for increasing knowledge about IRDs. Kidney transplant candidates undergoing transplant evaluation at 2 transplant centers were randomized to use Inform Me after routine transplant education (intervention) or routine transplant education alone (control). Computer adaptive learning method reinforced learning by embedding educational material, and initial (test 1) and additional test questions (test 2) into each chapter. Knowledge (primary outcome) was assessed in person after education (tests 1 and 2), and 1 week later by telephone (test 3). Controls did not receive test 2. Willingness to accept an IRD kidney (secondary outcome) was assessed after tests 1 and 3. Linear regression test 1 knowledge scores were used to test the significance of Inform Me exposure after controlling for covariates. Multiple imputation was used for intention-to-treat analysis. Two hundred eighty-eight KTCs participated. Intervention participants had higher test 1 knowledge scores (mean difference, 6.61; 95% confidence interval [95% CI], 5.37-7.86) than control participants, representing a 44% higher score than control participants' scores. Intervention participants' knowledge scores increased with educational reinforcement (test 2) compared with control arm test 1 scores (mean difference, 9.50; 95% CI, 8.27-10.73). After 1 week, intervention participants' knowledge remained greater than controls' knowledge (mean difference, 3.63; 95% CI, 2.49-4.78) (test 3). Willingness to accept an IRD kidney did not differ between study arms at tests 1 and 3. Inform Me use was associated with greater KTC knowledge about IRD kidneys above routine transplant education alone.

Comparing Single Case Design Overlap-Based Effect Size Metrics From Studies Examining Speech Generating Device Interventions

PubMed Central

Chen, Mo; Hyppa-Martin, Jolene K.; Reichle, Joe E.; Symons, Frank J.

2017-01-01

Meaningfully synthesizing single case experimental data from intervention studies comprised of individuals with low incidence conditions and generating effect size estimates remains challenging. Seven effect size metrics were compared for single case design (SCD) data focused on teaching speech generating device use to individuals with intellectual and developmental disabilities (IDD) with moderate to profound levels of impairment. The effect size metrics included percent of data points exceeding the median (PEM), percent of nonoverlapping data (PND), improvement rate difference (IRD), percent of all nonoverlapping data (PAND), Phi, nonoverlap of all pairs (NAP), and Taunovlap. Results showed that among the seven effect size metrics, PAND, Phi, IRD, and PND were more effective in quantifying intervention effects for the data sample (N = 285 phase or condition contrasts). Results are discussed with respect to issues concerning extracting and calculating effect sizes, visual analysis, and SCD intervention research in IDD. PMID:27119210

The effects of thyroxine or a GnRH analogue on thyroid hormone deiodination in the olfactory epithelium and retina of rainbow trout, Oncorhynchus mykiss, and sockeye salmon, Oncorhynchus nerka.

PubMed

Plate, E M; Adams, B A; Allison, W T; Martens, G; Hawryshyn, C W; Eales, J G

2002-06-01

Using low (0.5nM) substrate levels we determined the activities of thyroxine (T4) outer-ring deiodination (ORD), T4 inner-ring deiodination (T4IRD) and 3,5,3(')-triiodothyronine (T3) IRD activities in the olfactory epithelium (OLF) and retina (RET) of laboratory-held immature 1-year-old rainbow trout and immature 2.5-year-old sockeye salmon. In both species all three deiodination activities were detected in OLF and RET. For OLF, no particular pathway predominated and activities were similar to those of brain. For RET, T3IRD activity was greater than T4ORD activity and in sockeye RET T3IRD activity exceeded that of liver. Trout immersion for 6 weeks in 100ppm T4 increased plasma T4 levels 3-fold and plasma T3 levels by 50% and caused the anticipated autoregulatory responses in brain and liver deiodination ( downward arrow T4ORD, upward arrow T4IRD, and upward arrow T3IRD); OLF deiodination and RET T4ORD activity were unaltered but RET T4IRD and T3IRD activities increased dramatically. Two injections of a GnRH analogue (20 microgkg(-1)) into sockeye increased plasma T3 levels but not T4 levels and decreased RET T4IRD and T3IRD activities without changing liver, brain, or OLF deiodination. We conclude that in salmonids the main TH deiodination pathways occur in OLF but show no regulation by T4 or GnRH. In contrast, T3IRD activity predominates in RET and can be regulated by T4 and GnRH, suggesting that for RET plasma may be the major T3 source. These findings have implications for thyroidal regulation of sensory functions during salmonid diadromous migrations.

A Report on Molecular Diagnostic Testing for Inherited Retinal Dystrophies by Targeted Genetic Analyses.

PubMed

Ramkumar, Hema L; Gudiseva, Harini V; Kishaba, Kameron T; Suk, John J; Verma, Rohan; Tadimeti, Keerti; Thorson, John A; Ayyagari, Radha

2017-02-01

To test the utility of targeted sequencing as a method of clinical molecular testing in patients diagnosed with inherited retinal degeneration (IRD). After genetic counseling, peripheral blood was drawn from 188 probands and 36 carriers of IRD. Single gene testing was performed on each patient in a Clinical Laboratory Improvement Amendment (CLIA) certified laboratory. DNA was isolated, and all exons in the gene of interest were analyzed along with 20 base pairs of flanking intronic sequence. Genetic testing was most often performed on ABCA4, CTRP5, ELOV4, BEST1, CRB1, and PRPH2. Pathogenicity of novel sequence changes was predicted by PolyPhen2 and sorting intolerant from tolerant (SIFT). Of the 225 genetic tests performed, 150 were for recessive IRD, and 75 were for dominant IRD. A positive molecular diagnosis was made in 70 (59%) of probands with recessive IRD and 19 (26%) probands with dominant IRD. Analysis confirmed 12 (34%) of individuals as carriers of familial mutations associated with IRD. Thirty-two novel variants were identified; among these, 17 sequence changes in four genes were predicted to be possibly or probably damaging including: ABCA4 (14), BEST1 (2), PRPH2 (1), and TIMP3 (1). Targeted analysis of clinically suspected genes in 225 subjects resulted in a positive molecular diagnosis in 26% of patients with dominant IRD and 59% of patients with recessive IRD. Novel damaging mutations were identified in four genes. Single gene screening is not an ideal method for diagnostic testing given the phenotypic and genetic heterogeneity among IRD cases. High-throughput sequencing of all genes associated with retinal degeneration may be more efficient for molecular diagnosis.

GTF2IRD2 is located in the Williams–Beuren syndrome critical region 7q11.23 and encodes a protein with two TFII-I-like helix–loop–helix repeats

PubMed Central

Makeyev, Aleksandr V.; Erdenechimeg, Lkhamsuren; Mungunsukh, Ognoon; Roth, Jutta J.; Enkhmandakh, Badam; Ruddle, Frank H.; Bayarsaihan, Dashzeveg

2004-01-01

Williams–Beuren syndrome (also known as Williams syndrome) is caused by a deletion of a 1.55- to 1.84-megabase region from chromosome band 7q11.23. GTF2IRD1 and GTF2I, located within this critical region, encode proteins of the TFII-I family with multiple helix–loop–helix domains known as I repeats. In the present work, we characterize a third member, GTF2IRD2, which has sequence and structural similarity to the GTF2I and GTF2IRD1 paralogs. The ORF encodes a protein with several features characteristic of regulatory factors, including two I repeats, two leucine zippers, and a single Cys-2/His-2 zinc finger. The genomic organization of human, baboon, rat, and mouse genes is well conserved. Our exon-by-exon comparison has revealed that GTF2IRD2 is more closely related to GTF2I than to GTF2IRD1 and apparently is derived from the GTF2I sequence. The comparison of GTF2I and GTF2IRD2 genes revealed two distinct regions of homology, indicating that the helix–loop–helix domain structure of the GTF2IRD2 gene has been generated by two independent genomic duplications. We speculate that GTF2I is derived from GTF2IRD1 as a result of local duplication and the further evolution of its structure was associated with its functional specialization. Comparison of genomic sequences surrounding GTF2IRD2 genes in mice and humans allows refinement of the centromeric breakpoint position of the primate-specific inversion within the Williams–Beuren syndrome critical region. PMID:15243160

GTF2IRD2 is located in the Williams-Beuren syndrome critical region 7q11.23 and encodes a protein with two TFII-I-like helix-loop-helix repeats.

PubMed

Makeyev, Aleksandr V; Erdenechimeg, Lkhamsuren; Mungunsukh, Ognoon; Roth, Jutta J; Enkhmandakh, Badam; Ruddle, Frank H; Bayarsaihan, Dashzeveg

2004-07-27

Williams-Beuren syndrome (also known as Williams syndrome) is caused by a deletion of a 1.55- to 1.84-megabase region from chromosome band 7q11.23. GTF2IRD1 and GTF2I, located within this critical region, encode proteins of the TFII-I family with multiple helix-loop-helix domains known as I repeats. In the present work, we characterize a third member, GTF2IRD2, which has sequence and structural similarity to the GTF2I and GTF2IRD1 paralogs. The ORF encodes a protein with several features characteristic of regulatory factors, including two I repeats, two leucine zippers, and a single Cys-2/His-2 zinc finger. The genomic organization of human, baboon, rat, and mouse genes is well conserved. Our exon-by-exon comparison has revealed that GTF2IRD2 is more closely related to GTF2I than to GTF2IRD1 and apparently is derived from the GTF2I sequence. The comparison of GTF2I and GTF2IRD2 genes revealed two distinct regions of homology, indicating that the helix-loop-helix domain structure of the GTF2IRD2 gene has been generated by two independent genomic duplications. We speculate that GTF2I is derived from GTF2IRD1 as a result of local duplication and the further evolution of its structure was associated with its functional specialization. Comparison of genomic sequences surrounding GTF2IRD2 genes in mice and humans allows refinement of the centromeric breakpoint position of the primate-specific inversion within the Williams-Beuren syndrome critical region.

Centennial-millennial scale variations in Western Antarctic Ice Sheet discharge and their relationship to climate and ocean changes during the late Holocene

NASA Astrophysics Data System (ADS)

Snilstveit Hoem, Frida; Ninnemann, Ulysses S.; Kleiven, Helga (Kikki) F.; Irvali, Nil

2017-04-01

The Western Antarctic Ice Sheet (WAIS) may be highly sensitive to future warming and to ocean driven changes in subsurface melting. Understanding this sensitivity is critical as WAIS dynamics are a major source of uncertainty in sea level rise and regional climate projections. Although there is increasing evidence that WAIS discharge has varied on centennial to multi-millennial timescales since the last glacial period much less is known about its most recent (late Holocene) behavior. This period is particularly important as a baseline for delineating natural and anthropogenic influences and understanding potential coupling between climate, ocean circulation, and WAIS discharge. Here we present high-resolution records of WAIS discharge together with co-registered signals of surface and deep ocean physical property changes in a multicore taken from the southern flank of the North Scotia Sea Ridge (53˚ 31.813 S; 44˚ 42.143 W at 2750m water depth) spanning the past 4000 years. The site is situated just south/east of the polar front beyond the reach of seasonal sea ice and its potentially confounding influence on the ice-rafted debris (IRD) signal but still influenced by icebergs mostly originating from the WAIS. Our record of IRD from core GS08-151-02MC provides a centennially resolved record of iceberg supply from which we infer Antarctic ice-sheet dynamics and variability, while we use the oxygen and carbon isotopic composition of benthic (U. peregrina) and planktonic (N. pachyderma (s)) foraminifera to give (regional) information on past polar deep water and surface water temperatures, circulation and nutrients. Our results show higher amount of IRD between 4200-1800 cal yr B.P. This is in agreement with paleoclimate records reconstructing the onset of the neoglacial, sea ice expansion at about 5000 cal yr B.P. in the Atlantic sector of the Southern Ocean, and glaciers advancing in South America. The strongest IRD peak of the past millennium, which is otherwise a period of generally low IRD, coincides with Little Ice Age at 600 cal yr B.P. The local surface water hydrography appears relatively stable over the past 4000 years with the planktonic δ18O signal indicating centennial-millennial scale changes of typically ≤1˚ C (Δ0.22) and notably smaller in amplitude than the regional warming observed over the past century. The lack of correlation between surface water physical properties and IRD in the downcore records, suggests that IRD is not reflecting iceberg survival but rather changes in the supply (WAIS dynamics) or routing. Consistent with this interpretation, IRD covaries with climate on the Antarctic Peninsula (from JRI ice core) over the past 4 kyr with cooler conditions and lower amounts of IRD over much of the past two millennia than occurred earlier in the neoglaciation. Both records indicate a recovery with warming and increased IRD prior to industrialization. This relationship is consistent with the hypothesis that climate and specifically ocean temperatures were important for modulating WAIS discharge rates over the past few millennia.

Developing a Framework for Effective Network Capacity Planning

NASA Technical Reports Server (NTRS)

Yaprak, Ece

2005-01-01

As Internet traffic continues to grow exponentially, developing a clearer understanding of, and appropriately measuring, network's performance is becoming ever more critical. An important challenge faced by the Information Resources Directorate (IRD) at the Johnson Space Center in this context remains not only monitoring and maintaining a secure network, but also better understanding the capacity and future growth potential boundaries of its network. This requires capacity planning which involves modeling and simulating different network alternatives, and incorporating changes in design as technologies, components, configurations, and applications change, to determine optimal solutions in light of IRD's goals, objectives and strategies. My primary task this summer was to address this need. I evaluated network-modeling tools from OPNET Technologies Inc. and Compuware Corporation. I generated a baseline model for Building 45 using both tools by importing "real" topology/traffic information using IRD's various network management tools. I compared each tool against the other in terms of the advantages and disadvantages of both tools to accomplish IRD's goals. I also prepared step-by-step "how to design a baseline model" tutorial for both OPNET and Compuware products.

IRD evidence for Heinrich Events H1 and H2 on the NJ Margin

NASA Astrophysics Data System (ADS)

Christensen, B. A.; Calabrese, J.; O'Neill, C.; Goff, J. A.

2011-12-01

Recent seismic reflection studies suggest icebergs grounded on the late Pleistocene New Jersey margin (Goff and Austin, 2009) during Heinrich events H1 (~17 cal Ka), H2 (~23 cal Ka), H3 (~30 cal Ka) and H4 (~37 cal Ka). We tested this hypothesis by analyzing sediments on the upper NJ continental slope, near the area where icebergs were found. Ocean Drilling Program Site 1073A is located at 39°13.5214'N, 72°16.5461'W in 639 m water depth. The greater water depth increases the likelihood of preservation and improves the stratigraphic control. We obtained elemental measurements for Site 1073A Cores 1-6 using the X-ray Fluorescence (XRF) Core Scanner at the MARUM IODP core repository, University of Bremen. Cores were scanned at 10kV and 30kV to obtain a full suite of elements for analysis, with XRF data collected between 1 and 10 cm intervals. The values are reported in areas for the elements and were then converted to elemental ratios (Ca/Sr, Si/Sr, K/Al, and Si/Ti) for analysis. The origin of a Heinrich layer within an IRD belt can be identified by geochemical measures along with magnetic susceptibility and the presence of detrital materials that reflect its provenance (Hemming, 2004). Following analyses for Atlantic Ocean IRD by Hodell et al. (2008), higher Si/Sr values indicate abundant detrital silicates and low biogenic carbonate. Abundant detrital carbonate is identified by higher Ca/Sr values. K/Al may be used as a proxy for weathered matter being deposited and is a good indicator of terrigenous material (Yarincik, 2000). Si/Ti ratios may be used as a proxy for organic and siliceous productivity (Agnihotri, 2008). The elemental analysis was ground-truthed with grain size analysis at 10 cm intervals. Grain size analysis reveals large particles in a finer matrix at 123 cm and 284 cm. We interpret these as IRD. A linear sedimentation age model places the IRD around the time of Heinrich events H1 and H2. Age control is provided for the late Pleistocene principally by radiocarbon methods (McHugh and Olsson, 2002); however, the age model is not unequivocal so we present results for a few interpretations (linear sedimentation rates, and modeled). Nonetheless, the IRD is consistent with the timing of H1 and H2. While the IRD are obvious from the grain size analysis, we were not able to identify IRD from XRF elemental analyses. This may because the sediments are derived locally rather than transported from the higher latitudes, rendering IRD identification a function of grain size (anomalously large particles in a marine setting) rather than geochemistry. Alternatively, the particles were not close enough to the surface to impact the XRF response. This study provides further evidence for the presence of icebergs on the late Pleistocene NJ margin.

Inflammation-Related Morbidity and Mortality Among HIV-Positive Adults: How Extensive Is It?

PubMed

Hart, Brian B; Nordell, Anna D; Okulicz, Jason F; Palfreeman, Adrian; Horban, Andrzej; Kedem, Eynat; Neuhaus, Jacqueline; Jacobs, David R; Duprez, Daniel A; Neaton, James D

2018-01-01

To determine the rate of grade 4, potentially life-threatening events not attributable to AIDS, cardiovascular disease (CVD), or non-AIDS cancer among participants on antiretroviral therapy and to describe associations of these events with interleukin-6 (IL-6) and D-dimer. Cohort study. HIV-infected participants on antiretroviral therapy (N = 3568) with an HIV-RNA level ≤ 500 copies/mL were followed for grade 4, AIDS, CVD, non-AIDS cancer, and all-cause mortality events. Grade 4 events were further classified masked to biomarker levels as reflecting chronic inflammation-related disease (ChrIRD) or not (non-ChrIRD). Associations of baseline IL-6 and D-dimer with events were studied using Cox models. Over a median follow-up of 4.3 years, 339 participants developed a grade 4 event (22.9 per 1000 person-years); 165 participants developed a ChrIRD grade 4 event (10.7 per 1000 person-years). Grade 4 events were more common than AIDS (54 participants), CVD (132), and non-AIDS cancer (80) events, any of which developed in 252 participants (17.1 per 1000 person-years). Grade 4 and AIDS events were associated with similar risks of death. Higher IL-6 [hazard ratio (HR) = 1.19 per doubling of biomarker; P = 0.003] and D-dimer (HR = 1.23; P < 0.001) levels were associated with an increased risk of grade 4 events. IL-6 associations were stronger for ChrIRD (HR = 1.38; P < 0.001) than non-ChrIRD grade 4 events (HR = 1.11; P = 0.21). Morbidity and mortality associated with activation of inflammatory and coagulation pathways include conditions other than AIDS, CVD, and non-AIDS cancer events. Effective inflammation-dampening interventions could greatly affect the health of people with HIV.

Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.

PubMed

Howard, Monique L; Palmer, Stephen J; Taylor, Kylie M; Arthurson, Geoffrey J; Spitzer, Matthew W; Du, Xin; Pang, Terence Y C; Renoir, Thibault; Hardeman, Edna C; Hannan, Anthony J

2012-03-01

Insufficiency of the transcriptional regulator GTF2IRD1 has become a strong potential explanation for some of the major characteristic features of the neurodevelopmental disorder Williams-Beuren syndrome (WBS). Genotype/phenotype correlations in humans indicate that the hemizygous loss of the GTF2IRD1 gene and an adjacent paralogue, GTF2I, play crucial roles in the neurocognitive and craniofacial aspects of the disease. In order to explore this genetic relationship in greater detail, we have generated a targeted Gtf2ird1 mutation in mice that blocks normal GTF2IRD1 protein production. Detailed analyses of homozygous null Gtf2ird1 mice have revealed a series of phenotypes that share some intriguing parallels with WBS. These include reduced body weight, a facial deformity resulting from localised epidermal hyperplasia, a motor coordination deficit, alterations in exploratory activity and, in response to specific stress-inducing stimuli; a novel audible vocalisation and increased serum corticosterone. Analysis of Gtf2ird1 expression patterns in the brain using a knock-in LacZ reporter and c-fos activity mapping illustrates the regions where these neurological abnormalities may originate. These data provide new mechanistic insight into the clinical genetic findings in WBS patients and indicate that insufficiency of GTF2IRD1 protein contributes to abnormalities of facial development, motor function and specific behavioural disorders that accompany this disease. Copyright © 2011 Elsevier Inc. All rights reserved.

77 FR 4632 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-30

... aggregate IR&D costs or the costs of an individual IR&D project. The threshold for triggering the reporting... Agency auditor to support the allowability of the costs. Contractors that do not meet the threshold as a... provide in-process information from IR&D projects, for which reimbursement, as an allowable indirect cost...

Fiber Mode Scrambler for the Subaru Infrared Doppler Instrument (IRD)

NASA Astrophysics Data System (ADS)

Ishizuka, Masato; Kotani, Takayuki; Nishikawa, Jun; Kurokawa, Takashi; Mori, Takahiro; Kokubo, Tsukasa; Tamura, Motohide

2018-06-01

We report the results of fiber mode scrambler experiments for the Infra-Red Doppler instrument (IRD) on the Subaru 8.2-m telescope. IRD is a fiber-fed, high precision radial velocity (RV) instrument to search for exoplanets around nearby M dwarfs at near-infrared wavelengths. It is a high-resolution spectrograph with an Echelle grating. The expected RV measurement precision is ∼1 m s‑1 with a state of the art laser frequency comb for the wavelength calibration. In IRD observations, one of the most significant instrumental noise is a change of intensity distribution of multi-mode fiber exit, which degrades RV measurement precision. To stabilize the intensity distribution of fiber exit an introduction of fiber mode scrambler is mandatory. Several kinds of mode scramblers have been suggested in previous research, though it is necessary to determine the most appropriate mode scrambler system for IRD. Thus, we conducted systematic measurements of performance for a variety of mode scramblers, both static and dynamic. We tested various length multi-mode fibers, an octagonal fiber, a double fiber scrambler, and two kinds of dynamic scramblers, and their combinations. We report the performances of these mode scramblers and propose candidate mode scrambler systems for IRD.

Evidence for a dynamic East Antarctic ice sheet during the mid-Miocene climate transition

NASA Astrophysics Data System (ADS)

Pierce, Elizabeth L.; van de Flierdt, Tina; Williams, Trevor; Hemming, Sidney R.; Cook, Carys P.; Passchier, Sandra

2017-11-01

The East Antarctic ice sheet underwent a major expansion during the Mid-Miocene Climate Transition, around 14 Ma, lowering sea level by ∼60 m. However, direct or indirect evidence of where changes in the ice sheet occurred is limited. Here we present new insights on timing and locations of ice sheet change from two drill sites offshore East Antarctica. IODP Site U1356, Wilkes Land, and ODP Site 1165, Prydz Bay are located adjacent to two major ice drainage areas, the Wilkes Subglacial Basin and the Lambert Graben. Ice-rafted detritus (IRD), including dropstones, was deposited in concentrations far exceeding those known in the rest of the Miocene succession at both sites between 14.1 and 13.8 Ma, indicating that large amounts of IRD-bearing icebergs were calved from independent drainage basins during this relatively short interval. At Site U1356, the IRD was delivered in distinct pulses, suggesting that the overall ice advance was punctuated by short periods of ice retreat in the Wilkes Subglacial Basin. Provenance analysis of the mid-Miocene IRD and fine-grained sediments provides additional insights on the movement of the ice margin and subglacial geology. At Site U1356, the dominant 40Ar/39Ar thermochronological age of the ice-rafted hornblende grains is 1400-1550 Ma, differing from the majority of recent IRD in the area, from which we infer an inland source area of this thermochronological age extending along the eastern part of the Adélie Craton, which forms the western side of the Wilkes Subglacial Basin. Neodymium isotopic compositions from the terrigenous fine fraction at Site U1356 imply that the ice margin periodically expanded from high ground well into the Wilkes Subglacial Basin during periods of MMCT ice growth. At Site 1165, MMCT pebble-sized IRD are sourced from both the local Lambert Graben and the distant Aurora Subglacial Basin drainage area. Together, the occurrence and provenance of the IRD and glacially-eroded sediment at these two marine drill sites proximal to the Antarctic continent provide a previously undocumented record of dynamic ice margin change during the 14.1-13.8 Ma interval in three major East Antarctic drainage basins.

48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives. B&P...

48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives. B&P...

48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives. B&P...

48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives. B&P...

48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives. B&P...

Asynchronous North Atlantic iceberg discharges during the last glacial period explained through ocean circulation changes

NASA Astrophysics Data System (ADS)

Montoya, M.; Banderas, R.; Alvarez-Solas, J.; Robinson, A.

2017-12-01

Heinrich events (HEs) are episodes of increased ice-rafted debris (IRD) deposition in the North Atlantic Ocean that took place during stadials of the last glacial period, and are interpreted as massive iceberg discharges from the Laurentide Ice Sheet (LIS). IRD originating from the Fennoscandian ice sheet (FIS) accompany HEs during stadials, but enhanced calving has also been reported, however, during interstadials. While a number of mechanisms have been proposed to explain HEs involving the LIS, the role of the FIS during these events has not received much attention from a modeling perspective. Thus, a consistent explanation for the asynchronous occurrence of enhanced IRD throughout the North Atlantic is lacking. Here we investigate the response of the FIS to millennial-scale climate variability during the last glacial period. We use a hybrid three-dimensional thermomechanical ice-sheet model forced offline through a novel perturbative approach accounting for a more realistic treatment of millennial-scale climatic variability, including both the atmospheric and the oceanic components. Our results show that the FIS responds with enhanced iceberg discharges in phase with interstadial warmings in the North Atlantic. Separating the atmospheric and oceanic effects demonstrates the major role of the ocean in controlling the dynamics of the FIS on millennial timescales. While the atmospheric forcing alone is only able to produce modest iceberg discharges (< 0.02 Sv), the warmer oceanic surface waters lead to much higher rates of iceberg surges (ca. 0.1 Sv) as a result of relatively high basal melting rates within the margins of the ice sheet through the reactivation of ice streams in the northeastern (NE) part of the ice sheet. Together with previous work our results provide a consistent explanation for the asynchronous response of the LIS and the FIS to glacial abrupt climate changes. Finally, they support the notion that the FIS is a likely candidate to produce iceberg discharges during interstadials as suggested by IRD in the region.

Clinical characteristics and current therapies for inherited retinal degenerations.

PubMed

Sahel, José-Alain; Marazova, Katia; Audo, Isabelle

2014-10-16

Inherited retinal degenerations (IRDs) encompass a large group of clinically and genetically heterogeneous diseases that affect approximately 1 in 3000 people (>2 million people worldwide) (Bessant DA, Ali RR, Bhattacharya SS. 2001. Molecular genetics and prospects for therapy of the inherited retinal dystrophies. Curr Opin Genet Dev 11: 307-316.). IRDs may be inherited as Mendelian traits or through mitochondrial DNA, and may affect the entire retina (e.g., rod-cone dystrophy, also known as retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, choroideremia, Usher syndrome, and Bardet-Bidel syndrome) or be restricted to the macula (e.g., Stargardt disease, Best disease, and Sorsby fundus dystrophy), ultimately leading to blindness. IRDs are a major cause of severe vision loss, with profound impact on patients and society. Although IRDs remain untreatable today, significant progress toward therapeutic strategies for IRDs has marked the past two decades. This progress has been based on better understanding of the pathophysiological pathways of these diseases and on technological advances. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations

PubMed Central

Sahel, José-Alain; Marazova, Katia; Audo, Isabelle

2015-01-01

Inherited retinal degenerations (IRDs) encompass a large group of clinically and genetically heterogeneous diseases that affect approximately 1 in 3000 people (>2 million people worldwide) (Bessant DA, Ali RR, Bhattacharya SS. 2001. Molecular genetics and prospects for therapy of the inherited retinal dystrophies. Curr Opin Genet Dev 11: 307–316.). IRDs may be inherited as Mendelian traits or through mitochondrial DNA, and may affect the entire retina (e.g., rod–cone dystrophy, also known as retinitis pigmentosa, cone dystrophy, cone–rod dystrophy, choroideremia, Usher syndrome, and Bardet-Bidel syndrome) or be restricted to the macula (e.g., Stargardt disease, Best disease, and Sorsby fundus dystrophy), ultimately leading to blindness. IRDs are a major cause of severe vision loss, with profound impact on patients and society. Although IRDs remain untreatable today, significant progress toward therapeutic strategies for IRDs has marked the past two decades. This progress has been based on better understanding of the pathophysiological pathways of these diseases and on technological advances. PMID:25324231

Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis

PubMed Central

Lyberg, Torstein; Bottazzi, Barbara; Meroni, Pier Luigi; Leone, Roberto; Hjeltnes, Gunnbjorg

2017-01-01

Background Pentraxin 3 is proposed to be a marker of inflammation and cardiovascular risk, but its role in inflammatory rheumatic diseases (IRDs) is still uncertain. Therefore, we wanted to examine if anti-rheumatic treatment reduced serum PTX3 (s-PTX3) levels in IRDs, and if s-PTX3 levels were related to other markers of inflammation and to endothelial function (EF). Methods We examined s-PTX3, EF and established inflammatory biomarkers in 114 IRD patients from the PSARA study before and after 6 weeks and 6 months of treatment with methotrexate (MTX) or anti-tumor necrosis factor alpha (anti-TNF) therapy with or without MTX co-medication. Results s-PTX3 levels in all IRD diagnoses were above the upper limit of the reference range. In contrast to established inflammatory markers, in particular CRP and ESR, s-PTX3 levels did not change significantly after 6 weeks and 6 months of anti-rheumatic therapy. There was no difference in change in s-PTX3 levels from baseline to 6 weeks and 6 months between MTX monotherapy and anti-TNF regimens. CRP, ESR and EF were not related to changes in s-PTX3 neither in crude nor adjusted analyses. Conclusion IRD patients have increased s-PTX3 levels, which, in contrast to other inflammatory markers, do not seem to improve within 6 months of therapy with MTX and/or anti-TNF. Thus, s-PTX3 might reflect a persisting immune process, even a causal factor of inflammation, not inhibited by the standard anti-rheumatic treatment. Furthermore, even though s-PTX3 is thought to be a strong predictor of cardiovascular prognosis, it was not related to EF. PMID:28225768

Freshwater control of ice-rafted debris in the last glacial period at Mono Lake, California, USA

NASA Astrophysics Data System (ADS)

Zimmerman, Susan R. H.; Pearl, Crystal; Hemming, Sidney R.; Tamulonis, Kathryn; Hemming, N. Gary; Searle, Stephanie Y.

2011-09-01

The type section silts of the late Pleistocene Wilson Creek Formation at Mono Lake contain outsized clasts, dominantly well-rounded pebbles and cobbles of Sierran lithologies. Lithic grains > 425 μm show a similar pattern of variability as the > 10 mm clasts visible in the type section, with decreasing absolute abundance in southern and eastern outcrops. The largest concentrations of ice-rafted debris (IRD) occur at 67-57 ka and 46-32 ka, with strong millennial-scale variability, while little IRD is found during the last glacial maximum and deglaciation. Stratigraphic evidence for high lake level during high IRD intervals, and a lack of geomorphic evidence for coincidence of lake and glaciers, strongly suggests that rafting was by shore ice rather than icebergs. Correspondence of carbonate flux and IRD implies that both were mainly controlled by freshwater input, rather than disparate non-climatic controls. Conversely, the lack of IRD during the last glacial maximum and deglacial highstands may relate to secondary controls such as perennial ice cover or sediment supply. High IRD at Mono Lake corresponds to low glacial flour flux in Owens Lake, both correlative to high warm-season insolation. High-resolution, extra-basinal correlation of the millennial peaks awaits greatly improved age models for both records.

Stress inducible proteinase inhibitor diversity in Capsicum annuum

PubMed Central

2012-01-01

Background Wound-inducible Pin-II Proteinase inhibitors (PIs) are one of the important plant serine PIs which have been studied extensively for their structural and functional diversity and relevance in plant defense against insect pests. To explore the functional specialization of an array of Capsicum annuum (L.) proteinase inhibitor (CanPIs) genes, we studied their expression, processing and tissue-specific distribution under steady-state and induced conditions. Inductions were performed by subjecting C. annuum leaves to various treatments, namely aphid infestation or mechanical wounding followed by treatment with either oral secretion (OS) of Helicoverpa armigera or water. Results The elicitation treatments regulated the accumulation of CanPIs corresponding to 4-, 3-, and 2-inhibitory repeat domains (IRDs). Fourty seven different CanPI genes composed of 28 unique IRDs were identified in total along with those reported earlier. The CanPI gene pool either from uninduced or induced leaves was dominated by 3-IRD PIs and trypsin inhibitory domains. Also a major contribution by 4-IRD CanPI genes possessing trypsin and chymotrypsin inhibitor domains was specifically revealed in wounded leaves treated with OS. Wounding displayed the highest number of unique CanPIs while wounding with OS treatment resulted in the high accumulation of specifically CanPI-4, -7 and −10. Characterization of the PI protein activity through two dimensional gel electrophoresis revealed tissue and induction specific patterns. Consistent with transcript abundance, wound plus OS or water treated C. annuum leaves exhibited significantly higher PI activity and isoform diversity contributed by 3- and 4-IRD CanPIs. CanPI accumulation and activity was weakly elicited by aphid infestation yet resulted in the higher expression of CanPI-26, -41 and −43. Conclusions Plants can differentially perceive various kinds of insect attacks and respond appropriately through activating plant defenses including regulation of PIs at transcriptional and post-translational levels. Based on the differentially elicited CanPI accumulation patterns, it is intriguing to speculate that generating sequence diversity in the form of multi-IRD PIs is a part of elaborative plant defense strategy to obtain a diverse pool of functional units to confine insect attack. PMID:23153298

Rapid and accurate assessment of the activity measurements in Brazilian hospitals and clinics.

PubMed

de Oliveira, A E; Iwahara, A; da Cruz, P A L; da Silva, C J; de Araújo, E B; Mengatti, J; da Silva, R L; Trindade, O L

2018-04-01

Traceability in Nuclear Medicine Service (NMS) measurements was checked by the Institute of Radioprotection and Dosimetry (IRD) through the Institute of Energy and Nuclear Research (IPEN). In 2016, IRD ran an intercomparison program and invited Brazilian NMS authorized to administer 131 I to patients. Sources of 131 I were distributed to 33 NMSs. Three other sources from the same solution were sent to IRD, after measurement at IPEN. These sources were calibrated in the IRD reference system. A correction factor of 1.013 was obtained. Ninety percent of the NMS comparisons results are within ±10% of the National Laboratory of Metrology of Ionizing Radiation (LNMRI) value, the Brazilian legal requirement. Copyright © 2017 Elsevier Ltd. All rights reserved.

A shape and compositional analysis of ice-rafted debris in cores from IODP Expedition 323 in the Bering Sea

NASA Astrophysics Data System (ADS)

Dadd, Kelsie; Foley, Kristen

2016-03-01

Sediment cores recovered during IODP Expedition 323 in the Bering Sea, northern Pacific, contained numerous ice-rafted debris (IRD) clasts up to 85 mm in length. The physical properties (including roundness and sphericity) of 136 clasts from the working half of the cores, a subsample of the total clast number, were analysed and their composition determined using standard petrographic techniques. After removal of pumice and possible fall-in derived material from the clast population, a total of 86 clasts from the original collection were considered to be IRD. While roundness and sphericity vary greatly in the clast population, the IRD are predominately discoid in shape with oblate/prolate indices typically between -5 and 5. There are four time periods over the approximately 4.5 Ma sample interval, 0.36-0.67 Ma, 0.82-1.06 Ma 1.54-1.77 Ma and >3.28 Ma, where there are no IRD in the sample set for sites of the Bering slope, suggesting that these times may have been ice-free. Most clasts show some rounding and are likely to have spent time on beaches with wave action. Wave action on beaches suggests periods of no ice or only seasonal sea-ice. The low roundness values of other clasts, however, suggest they underwent little working and, therefore, the presence of glaciers or more permanent sea-ice at times in those locations. The abundance of rounded and unfaceted clasts as IRD suggests a lack of large ice sheets in the area during cool periods. Clast composition of the IRD is divided into four broad groups, basalt and andesite, granite and metamorphic, sedimentary, and felsic volcanic. The granite and metamorphic and more mature sedimentary lithologies are most likely derived from the Alaskan continental margin, while the extrusive igneous clasts could be derived from a variety of volcanic sources surrounding the Bering Sea, both emergent now or emergent at times of lower sea level. There is only a poor correlation with IRD abundance and marine isotope stages (MIS) for the time period <1 Ma. Abundant IRD occurs in MIS 3 and can be correlated with MIS back to 400 kyr but not to older ages. This suggests that the abundance of IRD >2 mm transported by sea-ice may not be a good indicator of past climate conditions.

Sequential stream segregation in normally-hearing and cochlear-implant listenersa)

PubMed Central

Tejani, Viral D.; Schvartz-Leyzac, Kara C.; Chatterjee, Monita

2017-01-01

Sequential stream segregation by normal hearing (NH) and cochlear implant (CI) listeners was investigated using an irregular rhythm detection (IRD) task. Pure tones and narrowband noises of different bandwidths were presented monaurally to older and younger NH listeners via headphones. For CI users, stimuli were delivered as pure tones via soundfield and via direct electrical stimulation. Results confirmed that tonal pitch is not essential for stream segregation by NH listeners and that aging does not reduce NH listeners' stream segregation. CI listeners' stream segregation was significantly poorer than NH listeners' with pure tone stimuli. With direct stimulation, however, CI listeners showed significantly stronger stream segregation, with a mean normalized pattern similar to NH listeners, implying that the CI speech processors possibly degraded acoustic cues. CI listeners' performance on an electrode discrimination task indicated that cues that are salient enough to make two electrodes highly discriminable may not be sufficiently salient for stream segregation, and that gap detection/discrimination, which must depend on perceptual electrode differences, did not play a role in the IRD task. Although the IRD task does not encompass all aspects of full stream segregation, these results suggest that some CI listeners may demonstrate aspects of stream segregation. PMID:28147600

A Role for Transcription Factor GTF2IRD2 in Executive Function in Williams-Beuren Syndrome

PubMed Central

Porter, Melanie A.; Dobson-Stone, Carol; Kwok, John B. J.; Schofield, Peter R.; Beckett, William; Tassabehji, May

2012-01-01

Executive functions are amongst the most heritable cognitive traits with twin studies indicating a strong genetic origin. However genes associated with this domain are unknown. Our research into the neurodevelopmental disorder Williams-Beuren syndrome (WBS) has identified a gene within the causative recurrent 1.5/1.6 Mb heterozygous microdeletion on chromosome 7q11.23, which may be involved in executive functioning. Comparative genome array screening of 55 WBS patients revealed a larger ∼1.8 Mb microdeletion in 18% of cases, which results in the loss of an additional gene, the transcription factor GTF2IRD2. The GTF gene family of transcription factors (GTF2I, GTF2IRD1 and GTF2IRD2) are all highly expressed in the brain, and GTF2I and GTF2IRD1 are involved in the pathogenesis of the cognitive and behavioural phenotypes associated with WBS. A multi-level analysis of cognitive, behavioural and psychological functioning in WBS patients showed that those with slightly larger deletions encompassing GTF2IRD2 were significantly more cognitively impaired in the areas of spatial functioning, social reasoning, and cognitive flexibility (a form of executive functioning). They also displayed significantly more obsessions and externalizing behaviours, a likely manifestation of poor cognitive flexibility and executive dysfunction. We provide the first evidence for a role for GTF2IRD2 in higher-level (executive functioning) abilities and highlight the importance of integrating detailed molecular characterisation of patients with comprehensive neuropsychological profiling to uncover additional genotype-phenotype correlations. The identification of specific genes which contribute to executive function has important neuropsychological implications in the treatment of patients with conditions like WBS, and will allow further studies into their mechanism of action. PMID:23118870

Liquid Motion in a Rotating Tank Experiment (LME)

NASA Technical Reports Server (NTRS)

Deffenbaugh, D. M.; Dodge, F. T.; Green, S. T.

1998-01-01

The Liquid Motion Experiment (LME), which flew on STS 84 in May 1997, was an investigation of liquid motions in spinning, nutating tanks. LME was designed to quantify the effects of such liquid motions on the stability of spinning spacecraft, which are known to be adversely affected by the energy dissipated by the liquid motions. The LME hardware was essentially a spin table which could be forced to nutate at specified frequencies at a constant cone angle, independently of the spin rate. Cylindrical and spherical test tanks, partially filled with liquids of different viscosities, were located at the periphery of the spin table to simulate a spacecraft with off-axis propellant tanks; one set of tanks contained generic propellant management devices (PMDs). The primary quantitative data from the flight tests were the liquid-induced torques exerted on the tanks about radial and tangential axes through the center of the tank. Visual recordings of the liquid oscillations also provided qualitative information. The flight program incorporated two types of tests: sine sweep tests, in which the spin rate was held constant and the nutation frequency varied over a wide range; and sine dwell test, in which both the spin rate and the nutation frequency were held constant. The sine sweep tests were meant to investigate all the prominent liquid resonant oscillations and the damping of the resonances, and the sine dwell tests were meant to quantify the viscous energy dissipation rate of the liquid oscillations for steady state conditions. The LME flight data were compared to analytical results obtained from two companion IR&D programs at Southwest Research Institute. The comparisons indicated that the models predicted the observed liquid resonances, damping, and energy dissipation rates for many test conditions but not for all. It was concluded that improved models and CFD simulations are needed to resolve the differences. This work is ongoing under a current IR&D program.

Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping.

PubMed

Mohammed, D; Yang, Q; Guy, R H; Matts, P J; Hadgraft, J; Lane, M E

2012-09-01

Skin surface tape-stripping is an extensively used technique to examine the distribution profile, penetration and safety of various active compounds. It is also a widely accepted method to probe skin barrier properties and more specifically, those of the stratum corneum (SC). The amount of SC removed by tape-stripping is generally determined either gravimetrically or by extraction and measurement of SC proteins. A novel infra-red densitometry (IRD) technique has recently been introduced to measure SC protein content. In the present study, IRD was investigated as an alternative method to measure the mass of SC removed by tape-stripping. Tape-stripping experiments were conducted on human volunteers. The weight of the stratum corneum removed was assessed by the gravimetric approach and by IRD. Transepidermal water loss (TEWL) was also measured before and after each tape-strip. A linear correlation coefficient was obtained for the data from the gravimetric and IRD measurements (r(2)=0.65; n=240). IRD is therefore proposed as a rapid, non-destructive alternative to the gravimetric approach to estimate the amount of SC removed by tape-stripping in vivo. Copyright © 2012 Elsevier B.V. All rights reserved.

Retinitis Pigmentosa with EYS Mutations Is the Most Prevalent Inherited Retinal Dystrophy in Japanese Populations.

PubMed

Arai, Yuuki; Maeda, Akiko; Hirami, Yasuhiko; Ishigami, Chie; Kosugi, Shinji; Mandai, Michiko; Kurimoto, Yasuo; Takahashi, Masayo

2015-01-01

The aim of this study was to gain information about disease prevalence and to identify the responsible genes for inherited retinal dystrophies (IRD) in Japanese populations. Clinical and molecular evaluations were performed on 349 patients with IRD. For segregation analyses, 63 of their family members were employed. Bioinformatics data from 1,208 Japanese individuals were used as controls. Molecular diagnosis was obtained by direct sequencing in a stepwise fashion utilizing one or two panels of 15 and 27 genes for retinitis pigmentosa patients. If a specific clinical diagnosis was suspected, direct sequencing of disease-specific genes, that is, ABCA4 for Stargardt disease, was conducted. Limited availability of intrafamily information and decreasing family size hampered identifying inherited patterns. Differential disease profiles with lower prevalence of Stargardt disease from European and North American populations were obtained. We found 205 sequence variants in 159 of 349 probands with an identification rate of 45.6%. This study found 43 novel sequence variants. In silico analysis suggests that 20 of 25 novel missense variants are pathogenic. EYS mutations had the highest prevalence at 23.5%. c.4957_4958insA and c.8868C>A were the two major EYS mutations identified in this cohort. EYS mutations are the most prevalent among Japanese patients with IRD.

[Progress in research on pathogenic genes and gene therapy for inherited retinal diseases].

PubMed

Zhu, Ling; Cao, Cong; Sun, Jiji; Gao, Tao; Liang, Xiaoyang; Nie, Zhipeng; Ji, Yanchun; Jiang, Pingping; Guan, Minxin

2017-02-10

Inherited retinal diseases (IRDs), including retinitis pigmentosa, Usher syndrome, Cone-Rod degenerations, inherited macular dystrophy, Leber's congenital amaurosis, Leber's hereditary optic neuropathy are the most common and severe types of hereditary ocular diseases. So far more than 200 pathogenic genes have been identified. With the growing knowledge of the genetics and mechanisms of IRDs, a number of gene therapeutic strategies have been developed in the laboratory or even entered clinical trials. Here the progress of IRD research on the pathogenic genes and therapeutic strategies, particularly gene therapy, are reviewed.

Intelligent Vision Systems Independent Research and Development (IR&D) 2006

NASA Technical Reports Server (NTRS)

Patrick, Clinton; Chavis, Katherine

2006-01-01

This report summarizes results in conduct of research sponsored by the 2006 Independent Research and Development (IR&D) program at Marshall Space Flight Center (MSFC) at Redstone Arsenal, Alabama. The focus of this IR&D is neural network (NN) technology provided by Imagination Engines, Incorporated (IEI) of St. Louis, Missouri. The technology already has many commercial, military, and governmental applications, and a rapidly growing list of other potential spin-offs. The goal for this IR&D is implementation and demonstration of the technology for autonomous robotic operations, first in software and ultimately in one or more hardware realizations. Testing is targeted specifically to the MSFC Flat Floor, but may also include other robotic platforms at MSFC, as time and funds permit. For the purpose of this report, the NN technology will be referred to by IEI's designation for a subset configuration of its patented technology suite: Self-Training Autonomous Neural Network Object (STANNO).

Spatial and Temporal Patterns of IRD Provenance in Glacial North Atlantic Sediments

NASA Astrophysics Data System (ADS)

Hemming, S. R.; Grousset, F. E.; Roy, M.; Julien, E.

2004-05-01

A full picture of ocean-atmosphere-ice sheet interactions awaits a thorough assessment of the array of different types of IRD layers with observations as well as models. Factors that must be considered in the observational studies are provenance (including geographic region of origin and whether icebergs or sea ice was the transporting agent), flux, relationship to sedimentological patterns such as grain size variations, and lateral sediment redistribution on the seafloor. We focus here on the provenance observations and their implications during the intervals of Heinrich layers H3 through H2, approximately 31 to 20 kyr. During the last glacial interval and prior to H3 (ca. 60-31 kyr), ice sheets had not achieved their maximum positions, and the abundance of IRD in marine sediments was generally lower as evidenced by standard measures such as %IRD and number of lithic grains per gram. H3 appears to be related to a modest IRD flux and it has been inferred to be a low foraminifera zone more than and IRD event. The map pattern of provenance variation within the H3 interval appears to be clearly relatable to surface current patterns and a significant portion of the continental derived detritus in eastern North Atlantic cores must have a European and/or Iceland+Greenland origin. In eastern Atlantic core VM28-82, the provenance varies abruptly across the low foraminifera interval of H3. In the Labrador Sea H3 has a composition like those of H1, H2, H4 and H5, suggesting a Hudson Strait source. Accordingly, the evidence appears to favor multiple sources of detritus (none of which overwhelmed the sediment load in the IRD belt) with a depositional pattern that is consistent with known surface currents. H1, H2, H4 and H5 can be traced far across the Atlantic to near Britain and Iberia based on the overwhelming Hudson Strait provenance. A difficulty in assessing geographical variations in the precursory intervals of Heinrich events is the rapid temporal variation in composition combined with the generally low resolution sampling. Hornblende 40Ar/39Ar ages within H2 cluster at 1.8 Ga (~75%), with most other grains being older. Below H2 in cores from Orphan Knoll (GGC31), off Newfoundland (VM23-14), in the Heinrich layer thickness maximum (SU90-11) the ages are much more scattered. Although more data are needed to make a firm conclusion, it appears that the interval just below the Hudson Strait provenance has a large Paleozoic source and just below that appears to be a mixture of Cenozoic (Icelandic hot spot) and ancient (Greenland?) grains. These observations are consistent with published petrological and Nd isotope evidence in the precursory interval of H2. Published evidence indicates a contrast between the precursory intervals of H2 and H4, consistent with the glaciers' not being at their maximum positions until after H3. It is expected that the precursory interval in eastern North Atlantic sources might be composed of largely different sources, similar to the implied provenance from the H3 map pattern.

Cargo Movement Operations System (CMOS) Interface Requirements Specification (Draft). Increment II

DTIC Science & Technology

1990-05-17

NO [ ] COMMENT DISPOSITION: COMMENT STATUS: OPEN [ 3 CLOSED [ ] ORIGINATOR CONTROL NUMBER: IRS1-0003 PROGRAM OFFICE CONTROL NUMBER: DATA ITEM DISCREPANCY WORKSHEET CDRL NUMBER: A004-05 DATE: 05/17/90 ORIGINATOR NAME: Ronald J. Lacour OFFICE SYMBOL: SAIC TELEPHONE NUMBER: 272-2999 SUBSTANTIVE: X EDITORIAL: PAGE NUMBER: 9 PARA NUMBER: 3.2 c. COMMENT OR RECOMMENDED CHANGE: Change line 2 to read, "CMOS IRD/SBSS-01 and SBSS-03." Move "CMOS IRD/SBSS-02" to paragraph 3.3 c. RATIONALE: The CMOS IRD/SBSS-02 covers the Shipment Suspense

Influenza research database: an integrated bioinformatics resource for influenza virus research

USDA-ARS?s Scientific Manuscript database

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics, an...

Panel-Based Clinical Genetic Testing in 85 Children with Inherited Retinal Disease.

PubMed

Taylor, Rachel L; Parry, Neil R A; Barton, Stephanie J; Campbell, Christopher; Delaney, Claire M; Ellingford, Jamie M; Hall, Georgina; Hardcastle, Claire; Morarji, Jiten; Nichol, Elisabeth J; Williams, Lindsi C; Douzgou, Sofia; Clayton-Smith, Jill; Ramsden, Simon C; Sharma, Vinod; Biswas, Susmito; Lloyd, I Chris; Ashworth, Jane L; Black, Graeme C; Sergouniotis, Panagiotis I

2017-07-01

To assess the clinical usefulness of genetic testing in a pediatric population with inherited retinal disease (IRD). Single-center retrospective case series. Eighty-five unrelated children with a diagnosis of isolated or syndromic IRD who were referred for clinical genetic testing between January 2014 and July 2016. Participants underwent a detailed ophthalmic examination, accompanied by electrodiagnostic testing (EDT) and dysmorphologic assessment where appropriate. Ocular and extraocular features were recorded using Human Phenotype Ontology terms. Subsequently, multigene panel testing (105 or 177 IRD-associated genes) was performed in an accredited diagnostic laboratory, followed by clinical variant interpretation. Diagnostic yield and clinical usefulness of genetic testing. Overall, 78.8% of patients (n = 67) received a probable molecular diagnosis; 7.5% (n = 5) of these had autosomal dominant disease, 25.4% (n = 17) had X-linked disease, and 67.2% (n = 45) had autosomal recessive disease. In a further 5.9% of patients (n = 5), a single heterozygous ABCA4 variant was identified; all these participants had a spectrum of clinical features consistent with ABCA4 retinopathy. Most participants (84.7%; n = 72) had undergone EDT and 81.9% (n = 59) of these patients received a probable molecular diagnosis. The genes most frequently mutated in the present cohort were CACNA1F and ABCA4, accounting for 14.9% (n = 10) and 11.9% (n = 8) of diagnoses respectively. Notably, in many cases, genetic testing helped to distinguish stationary from progressive IRD subtypes and to establish a precise diagnosis in a timely fashion. Multigene panel testing pointed to a molecular diagnosis in 84.7% of children with IRD. The diagnostic yield in the study population was significantly higher compared with that in previously reported unselected IRD cohorts. Approaches similar to the one described herein are expected to become a standard component of care in pediatric ophthalmology. We propose the introduction of genetic testing early in the diagnostic pathway in children with clinical and/or electrophysiologic findings, suggestive of IRD. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Ammonia Analysis by Gas Chromatograph/Infrared Detector (GC/IRD)

NASA Technical Reports Server (NTRS)

Scott, Joseph P.; Whitfield, Steve W.

2003-01-01

Methods are being developed at Marshall Space Flight Center's Toxicity Lab on a CG/IRD System that will be used to detect ammonia in low part per million (ppm) levels. These methods will allow analysis of gas samples by syringe injections. The GC is equipped with a unique cryogenic-cooled inlet system that will enable our lab to make large injections of a gas sample. Although the initial focus of the work will be analysis of ammonia, this instrument could identify other compounds on a molecular level. If proper methods can be developed, the IRD could work as a powerful addition to our offgassing capabilities.

Death and taxes are more than just a certainty.

PubMed

Blau, J M

2001-01-01

This article discusses a tax provision referenced under Internal Revenue Code Section 691(a) known as "Income in Respect of a Decedent" (IRD) and includes many circumstances applicable to physicians. "IRD" refers to income that accrued to the decedent but was not included in taxable income.

Neurophysiological correlates of word processing deficits in isolated reading and isolated spelling disorders.

PubMed

Bakos, Sarolta; Landerl, Karin; Bartling, Jürgen; Schulte-Körne, Gerd; Moll, Kristina

2018-03-01

In consistent orthographies, isolated reading disorders (iRD) and isolated spelling disorders (iSD) are nearly as common as combined reading-spelling disorders (cRSD). However, the exact nature of the underlying word processing deficits in isolated versus combined literacy deficits are not well understood yet. We applied a phonological lexical decision task (including words, pseudohomophones, legal and illegal pseudowords) during ERP recording to investigate the neurophysiological correlates of lexical and sublexical word-processing in children with iRD, iSD and cRSD compared to typically developing (TD) 9-year-olds. TD children showed enhanced early sensitivity (N170) for word material and for the violation of orthographic rules compared to the other groups. Lexical orthographic effects (higher LPC amplitude for words than for pseudohomophones) were the same in the TD and iRD groups, although processing took longer in children with iRD. In the iSD and cRSD groups, lexical orthographic effects were evident and stable over time only for correctly spelled words. Orthographic representations were intact in iRD children, but word processing took longer compared to TD. Children with spelling disorders had partly missing orthographic representations. Our study is the first to specify the underlying neurophysiology of word processing deficits associated with isolated literacy deficits. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Improvement in storage stability of infrared dried rough rice

USDA-ARS?s Scientific Manuscript database

The objective of this study was to develop infrared drying (IRD) method to improve the stability of physicochemical properties of rough rice during storage. The effect of IRD on the physicochemical properties of stored rough rice was compared with that of hot air drying (HAD) and ambient air drying ...

Reconstructing Southern Greenland Ice Sheet History During the Plio-Pleistocene Intensification of Northern Hemisphere Glaciation: Insights from IODP Site U1307

NASA Astrophysics Data System (ADS)

Blake-Mizen, K. R.; Hatfield, R. G.; Carlson, A. E.; Walczak, M. H.; Stoner, J. S.; Xuan, C.; Lawrence, K. T.; Bailey, I.

2017-12-01

Should it melt entirely, the Greenland Ice Sheet (GrIS) has the potential to raise global sea-level by 7 metres. With the Arctic continuing to warm at a remarkable rate, to better understand how the GrIS will respond to future anthropogenically-induced climate change we must constrain its natural variability in the geological past. In this regard, much uncertainty exists surrounding its pre-Quaternary history; particularly during the mid-Piacenzian warm period (mPWP; 3.3-3.0 Ma) - widely considered an analogue for near-future equilibrium climate with modern atmospheric CO2 levels and elevated temperatures relative to today - and the late Pliocene/early Pleistocene onset of widespread Northern Hemisphere glaciation (NHG, 2.7 Ma). GrIS reconstructions for these intervals have been largely hampered by a lack of well-dated, high-resolution records from suitable sites. To address this, we present new high-resolution, multi-proxy records from IODP Site U1307, a North Atlantic marine sediment core recovered from the Eirik Drift just south of Greenland. Generation of a new high-resolution relative palaeointensity (RPI)-based age-model - representing the first of its kind for high-latitude sediments deposited during NHG - has enabled strong orbital age control. Our ice-rafted debris (IRD) record confirms a 2.72 Ma initiation of major southern GrIS marine-terminating glaciations, which appear to persist even through interglacial periods up to at least 2.24 Ma. XRF-scanning and IRD evidence suggests, however, that an ephemeral ice-cap of likely considerable size persisted on southern Greenland prior to the mPWP. These data, together with the analysed provenance of individual IRD, indicate marine-based GrIS margins extended southward over the NHG interval and only occurred on Greenland's southern tip from 2.7 Ma. Despite a large increase in the deposition of GrIS-derived IRD from this time, bulk sedimentation rates and magnetic grain-size dropped significantly, implying that the onset of NHG 2.7 Ma was associated with a change in the strength and/or depth of the Western Boundary Undercurrent at the site. IODP Site U1307 therefore provides a unique opportunity to constrain southern GrIS behaviour and deep-ocean response during these key climatic intervals, lending valuable lessons to future predictions.

Effectiveness of cough etiquette maneuvers in disrupting the chain of transmission of infectious respiratory diseases

PubMed Central

2013-01-01

Background The effectiveness of recommended measures, such as “cover your mouth when coughing”, in disrupting the chain of transmission of infectious respiratory diseases (IRD) has been questioned. The objective of the current study was to determine the effectiveness of simple primary respiratory hygiene/cough etiquette maneuvers in blocking droplets expelled as aerosol during coughing. Method In this study, 31 healthy non-smokers performed cough etiquette maneuvers in an effort to cover their voluntarily elicited best effort coughs in an open bench format. A laser diffraction system was used to obtain accurate, non-invasive, quantitative, real time measurements of the size and number of droplets emitted during the assessed cough etiquette maneuvers. Results Recommended cough etiquette maneuvers did not block the release and dispersion of a variety of different diameter droplets to the surrounding environment. Droplets smaller than one-micron size dominate the total number of droplets leaked when practicing assessed maneuvers. Conclusions All the assessed cough etiquette maneuvers, performed as recommended, do not block droplets expelled as aerosol when coughing. This aerosol can penetrate profound levels of the respiratory system. Practicing these assessed primary respiratory hygiene/cough etiquette maneuvers would still permit direct, indirect, and/or airborne transmission and spread of IRD, such as influenza and Tuberculosis. All the assessed cough etiquette maneuvers, as recommended, do not fully interrupt the chain of transmission of IRD. This knowledge urges us all to critically review recommended CE and to search for new evidence-based procedures that effectively disrupt the transmission of respiratory pathogens. Interrupting the chain of transmission of IRD will optimize the protection of first responders, paramedics, nurses, and doctors working in triage sites, emergency rooms, intensive care units, and the general public against cough-droplet-spread diseases. PMID:24010919

Indian Resource Development. Annual Report, 1984-1985.

ERIC Educational Resources Information Center

New Mexico State Univ., Las Cruces.

Operating in 1984-85 with a budget of $216,000 appropriated by the New Mexico State Legislature, the Indian Resource Development (IRD) Program continued its efforts to develop a corps of professionally trained American Indians in fields related to natural resource development. As of June 1985 IRD maintained a roll of 863 participants--Indian…

Gene therapy for inherited retinal and optic nerve degenerations.

PubMed

Moore, Nicholas A; Morral, Nuria; Ciulla, Thomas A; Bracha, Peter

2018-01-01

The eye is a target for investigational gene therapy due to the monogenic nature of many inherited retinal and optic nerve degenerations (IRD), its accessibility, tight blood-ocular barrier, the ability to non-invasively monitor for functional and anatomic outcomes, as well as its relative immune privileged state.Vectors currently used in IRD clinical trials include adeno-associated virus (AAV), small single-stranded DNA viruses, and lentivirus, RNA viruses of the retrovirus family. Both can transduce non-dividing cells, but AAV are non-integrating, while lentivirus integrate into the host cell genome, and have a larger transgene capacity. Areas covered: This review covers Leber's congenital amaurosis, choroideremia, retinitis pigmentosa, Usher syndrome, Stargardt disease, Leber's hereditary optic neuropathy, Achromatopsia, and X-linked retinoschisis. Expert opinion: Despite great potential, gene therapy for IRD raises many questions, including the potential for less invasive intravitreal versus subretinal delivery, efficacy, safety, and longevity of response, as well as acceptance of novel study endpoints by regulatory bodies, patients, clinicians, and payers. Also, ultimate adoption of gene therapy for IRD will require widespread genetic screening to identify and diagnose patients based on genotype instead of phenotype.

Reduced appropriate implantable cardioverter-defibrillator therapy after cardiac resynchronization therapy-induced left ventricular function recovery: a meta-analysis and systematic review.

PubMed

Chatterjee, Neal A; Roka, Attila; Lubitz, Steven A; Gold, Michael R; Daubert, Claude; Linde, Cecilia; Steffel, Jan; Singh, Jagmeet P; Mela, Theofanie

2015-11-01

For patients undergoing cardiac resynchronization therapy (CRT) with implantable cardioverter-defibrillator (ICD; CRT-D), the effect of an improvement in left ventricular ejection fraction (LVEF) on appropriate ICD therapy may have significant implications regarding management at the time of ICD generator replacement. We conducted a meta-analysis to determine the effect of LVEF recovery following CRT on the incidence of appropriate ICD therapy. A search of multiple electronic databases identified 709 reports, of which 6 retrospective cohort studies were included (n = 1740). In patients with post-CRT LVEF ≥35% (study n = 4), the pooled estimated rate of ICD therapy (5.5/100 person-years) was significantly lower than patients with post-CRT LVEF <35% [incidence rate difference (IRD): -6.5/100 person-years, 95% confidence interval (95% CI): -8.8 to -4.2, P < 0.001]. Similarly, patients with post-CRT LVEF ≥45% (study n = 4) demonstrated lower estimated rates of ICD therapy (2.3/100 person-years) compared with patients without such recovery (IRD: -5.8/100 person-years, 95% CI: -7.6 to -4.0, P < 0.001). Restricting analysis to studies discounting ICD therapies during LVEF recovery (study n = 3), patients with LVEF recovery (≥35 or ≥45%) had significantly lower rates of ICD therapy compared with patients without such recovery (P for both <0.001). Patients with primary prevention indication for ICD, regardless of LVEF recovery definition, had very low rates of ICD therapy (0.4 to 0.8/100-person years). Recovery of LVEF post-CRT is associated with significantly reduced appropriate ICD therapy. Patients with improvement of LVEF ≥45% and those with primary prevention indication for ICD appear to be at lowest risk. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Real-World Assessment of Renal and Bone Safety among Patients with HIV Infection Exposed to Tenofovir Disoproxil Fumarate-Containing Single-Tablet Regimens.

PubMed

Nkhoma, Ella T; Rosenblatt, Lisa; Myers, Joel; Villasis-Keever, Angelina; Coumbis, John

2016-01-01

Tenofovir disoproxil fumarate (TDF)-containing antiretroviral regimens have been associated with an increased incidence of renal and bone adverse outcomes. Here, we estimated the real-world incidence of renal and bone adverse outcomes among patients with HIV infection receiving different TDF-containing single-tablet regimens (STRs). This cohort study used US health insurance data spanning the years 2008-2014. We identified HIV-infected patients aged ≥18 years (all HIV patients) and those with ≥6 months of continuous enrollment prior to initiating efavirenz/emtricitabine/TDF (EFV/FTC/TDF), rilpivirine/FTC/TDF (RPV/FTC/TDF) or elvitegravir/cobicistat/FTC/TDF (EVG/COBI/FTC/TDF). Renal adverse outcomes were identified using renal International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes. Bone adverse outcomes were identified using ICD-9-CM diagnosis codes for fracture. Incidence rates (IRs) and associated 95% confidence intervals (CIs) were estimated assuming a Poisson distribution, and outcomes between STRs were compared using IR ratios (IRRs) and IR differences (IRDs). We identified 9876 and 10,383 eligible patients for the renal and fracture analyses, respectively. Observed IRs for renal adverse outcomes were 9.7, 10.5, 13.6, and 18.0 per 1000 person-years among those receiving EFV/FTC/TDF, RPV/FTC/TDF, or EVG/COBI/FTC/TDF, or all HIV patients, respectively. Corresponding values for IRs of fracture were 3.4, 3.6, 7.2, and 4.4 per 1000 person-years, respectively. Renal adverse outcomes with EFV/FTC/TDF were significantly less frequent than with EVG/COBI/FTC/TDF (IRD -3.96; 95% CI: -7.31, -1.06). No IRR differences were identified for the renal analysis. Fractures with EFV/FTC/TDF were significantly less frequent than with EVG/COBI/FTC/TDF (IRR 0.47; 95% CI: 0.27, 0.81 and IRD -3.85; 95% CI: -5.02, -2.78). In this large real-world database, observed IRs for renal adverse outcomes with TDF-containing STRs were lower or similar to those for all HIV patients, with the lowest IRs observed among patients receiving EFV/FTC/TDF. Compared with all HIV patients, the observed IR for fracture was higher with EVG/COBI/FTC/TDF, comparable with RPV/FTC/TDF, and lower with EFV/FTC/TDF.

48 CFR 9904.420-50 - Techniques for application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... shall be excluded from the IR&D and B&P cost pools to be allocated to other segments and the base data... final cost objectives and the particular final cost objective's base data shall be excluded from the... costs of all other IR&D and B&P projects shall be allocated among all segments by means of the same base...

Influenza Research Database: An integrated bioinformatics resource for influenza virus research.

PubMed

Zhang, Yun; Aevermann, Brian D; Anderson, Tavis K; Burke, David F; Dauphin, Gwenaelle; Gu, Zhiping; He, Sherry; Kumar, Sanjeev; Larsen, Christopher N; Lee, Alexandra J; Li, Xiaomei; Macken, Catherine; Mahaffey, Colin; Pickett, Brett E; Reardon, Brian; Smith, Thomas; Stewart, Lucy; Suloway, Christian; Sun, Guangyu; Tong, Lei; Vincent, Amy L; Walters, Bryan; Zaremba, Sam; Zhao, Hongtao; Zhou, Liwei; Zmasek, Christian; Klem, Edward B; Scheuermann, Richard H

2017-01-04

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Correlation of Brunhes detrital-layer stratigraphy into the North Atlantic from Orphan Knoll (Labrador Sea)

NASA Astrophysics Data System (ADS)

Channell, J. E.; Hodell, D. A.; Romero, O. E.; Hillaire-Marcel, C.; de Vernal, A.; Stoner, J. S.; Mazaud, A.; Roehl, U.

2011-12-01

IODP Site U1302-U1303, on the SE flank of Orphan Knoll (Labrador Sea), has a record of detrital layers that extends through most of the Brunhes Chron. The age model is built by tandem matching of relative paleointensity (RPI) and oxygen isotope data (δ18O) from Neogloboquadrina pachyderma (sin.) to reference records, indicating a mean Brunhes sedimentation rate of 14 cm/kyr. Sedimentation back to marine isotope stage (MIS) 18 is characterized by detrital layers that are detected by higher than background gamma-ray attenuation (GRA) density, peaks in X-ray fluorescence (XRF) indicators for detrital carbonate (Ca/Sr) and detrital silicate (Si/Sr), an ice-rafted debris (IRD) proxy (>106 μm), magnetic susceptibility, and magnetic grain-size peaks. The age model enables correlation of Site U1302/03 to IODP Site U1308 (re-drill of DSDP Site 609) in the heart of the central Atlantic IRD belt where an age model and a similar set of detrital-layer proxies have already been derived. Ages of Heinrich layers H1, H2, H4, H5 and H6 are within ~2 kyr at the two sites (H0, H3 and H5a are not observed at Site U1308), and agree with previous work at Orphan Knoll within ~3 kyr. At Site U1308, Brunhes detrital layers are restricted to peak glacials and glacial terminations back to MIS16, however, these same proxies at Site U1302/03 indicate detrital layers distributed throughout the record in both glacial and most interglacial stages. At Site U1302/03, we distinguish Heinrich-type layers in glacial stages, which are associated with IRD (some of which have near-synchronous analogues at Site U1308), from detrital layers within interglacial stages manifested by multiple detrital layer proxies (including Ca/Sr) but usually not associated with IRD, that may be attributed to a distinct depositional process, namely drainage and debris-flow events funneled down the nearby NAMOC (North Atlantic Mid-Ocean Channel).

Geochronology and paleoceanographic history of Quaternary sediments from southwestern part of Pacific-Antarctic Ridge, the Ross Sea, Antarctica

NASA Astrophysics Data System (ADS)

Murayama, M.; Yagi, Y.; Mishima, T.; Horikawa, K.; Sagawa, T.; Kodama, K.; Kato, Y.; Minagawa, M.

2006-12-01

Paleoceanographic studies in the southern hemisphere high latitudes are important for understanding the global climate system. These detailed records of the oceanic response to various climate conditions are well- documented in marine sediments. The main goal of this study is to construct the precise chronostratigraphy and to reveal the paleocenographic and sedimentological changes in this region during Quaternary. A piston core SX-09 (65 10.79' S, 174 04.77' W, 3336 m water depth) which was recovered from southwestern part of Pacific-Antarctic Ridge, the Ross Sea, Antarctica during the R/V Hakuho-Maru KH02-4 cruise, was composed mainly of foraminifer bearing siliceous clay with ice-rafted debris (IRDs). To date, magnetostratigraphy and benthic foraminifer oxygen isotope were adopted. Remanent magnetization of the U-channel samples was measured with a 2G superconducting rock magnetometer. Stable characteristic remanent magnetization was isolated by subjecting the samples to progressive alternating field demagnezation. By referring the obtained magnetic polarity sequence with the geomagnetic polarity time scale (GPTS) by Cande and Kent (2005), we estimated the age of this core. Epoch boundary placed the Brouhes-Matuyama at 0.78 Ma was existed between 565 to 720 cmbsf. This suggested that the boundary was affected by IRDs distribution and/or by high sedimentation rate. The depth of 720 cmbsf to the bottom (1480 cm) was correlated with reverse of Matuyama Chron (Chrons C1r, ~2.58 Ma). Jaramillo Subchron (Chron C1r. 1n, 0.99-1.07 Ma) correlated clearly with the depths of 1012-1076 cmbsf. The average sedimentation rate calculated by the epoch boundary ages was approximately 0.7-1.5 cm/kyr. We will discuss more detail age control combined with d-18O data and the IRDs abundance corresponded to the glacial history in the Antarctic Sea.

RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome.

PubMed

Corley, Susan M; Canales, Cesar P; Carmona-Mora, Paulina; Mendoza-Reinosa, Veronica; Beverdam, Annemiek; Hardeman, Edna C; Wilkins, Marc R; Palmer, Stephen J

2016-06-13

Williams-Beuren Syndrome (WBS) is a genetic disorder associated with multisystemic abnormalities, including craniofacial dysmorphology and cognitive defects. It is caused by a hemizygous microdeletion involving up to 28 genes in chromosome 7q11.23. Genotype/phenotype analysis of atypical microdeletions implicates two evolutionary-related transcription factors, GTF2I and GTF2IRD1, as prime candidates for the cause of the facial dysmorphology. Using a targeted Gtf2ird1 knockout mouse, we employed massively-parallel sequencing of mRNA (RNA-Seq) to understand changes in the transcriptional landscape associated with inactivation of Gtf2ird1 in lip tissue. We found widespread dysregulation of genes including differential expression of 78 transcription factors or coactivators, several involved in organ development including Hey1, Myf6, Myog, Dlx2, Gli1, Gli2, Lhx2, Pou3f3, Sox2, Foxp3. We also found that the absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. At the same time, there was a decrease in the expression of genes involved in other signalling mechanisms, including the Wnt pathway, indicating dysregulation in the complex networks necessary for epidermal differentiation and facial skin patterning. Several of the differentially expressed genes have known roles in both tissue development and neurological function, such as the transcription factor Lhx2 which regulates several genes involved in both skin and brain development. Gtf2ird1 inactivation results in widespread gene dysregulation, some of which may be due to the secondary consequences of gene regulatory network disruptions involving several transcription factors and signalling molecules. Genes involved in growth factor signalling and cell cycle progression were identified as particularly important for explaining the skin dysmorphology observed in this mouse model. We have noted that a number of the dysregulated genes have known roles in brain development as well as epidermal differentiation and maintenance. Therefore, this study provides clues as to the underlying mechanisms that may be involved in the broader profile of WBS.

Using Sediment Provenance to Study Ice Streams in the Weddell Sea Embayment of Antarctica

NASA Astrophysics Data System (ADS)

Hemming, S. R.; Williams, T.; Boswell, S.; Licht, K.; Agrios, L.; Brachfeld, S. A.; van de Flierdt, T.; Kuhn, G.; Hillenbrand, C. D.; Zhai, X.

2016-12-01

The geochemical and geochronological fingerprint of rock debris eroded and carried by ice streams may be used to identify the provenance of iceberg-rafted debris (IRD) in the marine sediment record. During deglacial times it has been shown that there is an increase in IRD accumulation in marine sediments underlying the western limb of the Weddell Gyre. We seek to find the provenance of this IRD, identify the ice streams contributing to the IRD load, and interpret the geographic sequence of ice sheet retreat in the Weddell Sea embayment for the last three deglaciations. In December 2014 we conducted fieldwork to collect samples of rock and sediment debris carried by three of the major ice streams draining the Weddell Sea embayment: the Foundation Ice Stream, the Academy Glacier, and the Recovery Glacier. We sampled both modern moraines at the edges of the ice streams and older till on hillsides next to the ice streams. In addition to rocks representing the geology of local outcrops, we found that each of the three ice streams carries a characteristic set of erratic lithologies from further upstream, giving clues to the geology hidden under the ice sheet. Downstream, subglacial till and proximal glaciomarine sediment from existing core sites located at the edge of the Filchner and Ronne Ice Shelves, collected on past expeditions of the RV Polarstern, characterize the geochemical and geochronological fingerprint along ice flow lines extending from the ice streams. Finally, two deep-water RV Polarstern sites contain a continuous record of IRD sourced from the set of Weddell embayment ice streams over the last few glacial cycles. Here we present new 40Ar/39Ar hornblende and biotite thermochronological data from individual mineral grains, K-Ar from the silt fraction, and U-Pb zircon geochronology from the onshore tills and offshore sediments. Using this data we will discuss provenance matching between the IRD and the ice streams, and the possibilities for using provenance to understand ice sheet dynamics over the course of glacial cycles.

Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases

PubMed Central

2017-01-01

Purpose Inflammatory rheumatic diseases (IRD) are associated with accelerated coronary artery disease (CAD), which may result from both systemic and vascular wall inflammation. There are indications that complement may be involved in the pathogenesis of CAD in Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). This study aimed to evaluate the associations between circulating complement and complement activation products with mononuclear cell infiltrates (MCI, surrogate marker of vascular inflammation) in the aortic media and adventitia in IRDCAD and non-IRDCAD patients undergoing coronary artery bypass grafting (CABG). Furthermore, we compared complement activation product deposition patterns in rare aorta adventitial and medial biopsies from SLE, RA and non-IRD patients. Methods We examined plasma C3 (p-C3) and terminal complement complexes (p-TCC) in 28 IRDCAD (SLE = 3; RA = 25), 52 non-IRDCAD patients, and 32 IRDNo CAD (RA = 32) from the Feiring Heart Biopsy Study. Aortic biopsies taken from the CAD only patients during CABG were previously evaluated for adventitial MCIs. The rare aortic biopsies from 3 SLE, 3 RA and 3 non-IRDCAD were assessed for the presence of C3 and C3d using immunohistochemistry. Results IRDCAD patients had higher p-TCC than non-IRDCAD or IRDNo CAD patients (p<0.0001), but a similar p-C3 level (p = 0.42). Circulating C3 was associated with IRD duration (ρ, p-value: 0.46, 0.03). In multiple logistic regression analysis, IRD remained significantly related to the presence and size of MCI (p<0.05). C3 was present in all tissue samples. C3d was detected in the media of all patients and only in the adventitia of IRD patients (diffuse in all SLE and focal in one RA). Conclusion The independent association of IRD status with MCI and the observed C3d deposition supports the unique relationship between rheumatic disease, and, in particular, SLE with the complement system. Exaggerated systemic and vascular complement activation may accelerate CVD, serve as a CVD biomarker, and represent a target for new therapies. PMID:28362874

Influenza Research Database: an integrated bioinformatics resource for influenza research and surveillance

PubMed Central

Squires, R. Burke; Noronha, Jyothi; Hunt, Victoria; García‐Sastre, Adolfo; Macken, Catherine; Baumgarth, Nicole; Suarez, David; Pickett, Brett E.; Zhang, Yun; Larsen, Christopher N.; Ramsey, Alvin; Zhou, Liwei; Zaremba, Sam; Kumar, Sanjeev; Deitrich, Jon; Klem, Edward; Scheuermann, Richard H.

2012-01-01

Please cite this paper as: Squires et al. (2012) Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. Influenza and Other Respiratory Viruses 6(6), 404–416. Background  The recent emergence of the 2009 pandemic influenza A/H1N1 virus has highlighted the value of free and open access to influenza virus genome sequence data integrated with information about other important virus characteristics. Design  The Influenza Research Database (IRD, http://www.fludb.org) is a free, open, publicly‐accessible resource funded by the U.S. National Institute of Allergy and Infectious Diseases through the Bioinformatics Resource Centers program. IRD provides a comprehensive, integrated database and analysis resource for influenza sequence, surveillance, and research data, including user‐friendly interfaces for data retrieval, visualization and comparative genomics analysis, together with personal log in‐protected ‘workbench’ spaces for saving data sets and analysis results. IRD integrates genomic, proteomic, immune epitope, and surveillance data from a variety of sources, including public databases, computational algorithms, external research groups, and the scientific literature. Results  To demonstrate the utility of the data and analysis tools available in IRD, two scientific use cases are presented. A comparison of hemagglutinin sequence conservation and epitope coverage information revealed highly conserved protein regions that can be recognized by the human adaptive immune system as possible targets for inducing cross‐protective immunity. Phylogenetic and geospatial analysis of sequences from wild bird surveillance samples revealed a possible evolutionary connection between influenza virus from Delaware Bay shorebirds and Alberta ducks. Conclusions  The IRD provides a wealth of integrated data and information about influenza virus to support research of the genetic determinants dictating virus pathogenicity, host range restriction and transmission, and to facilitate development of vaccines, diagnostics, and therapeutics. PMID:22260278

Insights into the Geographic Sequence of Deglaciation in the Weddell Sea Embayment by Provenance of Ice-Rafted Debris

NASA Astrophysics Data System (ADS)

Williams, T.; Hemming, S. R.; Licht, K.; Agrios, L.; Brachfeld, S. A.; van de Flierdt, T.; Hillenbrand, C. D.; Ehrmann, W. U.; Zhai, X.; Cai, Y.; Corley, A. D.; Kuhn, G.

2017-12-01

The geochemical and geochronological fingerprint of rock debris eroded and carried by ice streams may be used to identify the provenance of iceberg-rafted debris (IRD) in the marine sediment record. During ice retreat following glacial maxima, it has been shown that there is an increase in IRD accumulation in marine sediments underlying the western limb of the Weddell Gyre. Here we present IRD provenance records from sediment core PS1571-1 in the NW Weddell Sea, and interpret these records in terms of the geographic sequence of ice sheet retreat in the Weddell Sea embayment during the most recent deglaciation. We first characterize the source areas of eroded debris around the Weddell Sea Embayment, using published mapping of the embayment and new material from: 1. Till in modern moraines at the edges of ice streams, including the Foundation Ice Stream, the Academy Glacier, and the Recovery Glacier; and 2. Subglacial till and proximal glaciomarine sediment from existing cores located along the front of the Filchner and Ronne Ice Shelves, collected on past expeditions of the RV Polarstern. The analyses on these samples include 40Ar/39Ar hornblende and biotite thermochronology and U-Pb zircon geochronology on individual mineral grains, and K-Ar thermochronology, Nd isotopes, and clay mineralogy on the clay grain size fraction. Results so far indicate that samples along the front of the Filchner and Ronne Ice Shelves record the geochemical and geochronological fingerprint that would be expected from tracing ice flow lines back to the bedrock terranes. The Ronne (west), Hughes (central), and Filchner (east) sectors have distinguishable provenance source signatures, and further subdivision is possible. In core PS1571-1, downcore IRD provenance changes reflect iceberg output and ice sheet retreat from the different sectors of the embayment through the last deglaciation. The detrital provenance method of interpreting the geographic sequence of ice retreat can equally be applied to previous deglaciations of the Weddell Sea Embayment.

Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic lung disease in premature infants.

PubMed Central

Little, S.; Dean, T.; Bevin, S.; Hall, M.; Ashton, M.; Church, M.; Warner, J.; Shute, J.

1995-01-01

BACKGROUND--Pulmonary neutrophilia characterises both the relatively transient inflammation associated with infant respiratory distress syndrome (IRDS) and the persistent inflammation of chronic lung disease. The possibility that persistently raised markers of inflammation indicate the development of chronic lung disease in low birth weight (< 1730 g) preterm (< 31 weeks) infants was therefore investigated. METHODS--Soluble ICAM-1 (sICAM-1) levels in plasma, and interleukin (IL)-8 and myeloperoxidase (MPO) levels in bronchial lavage fluid (BLF) obtained from 17 infants on days 1, 5, and 14 following birth were measured and correlations with the number of neutrophils in BLF sought. Peripheral neutrophils were isolated on Polymorphoprep and chemotactic responsiveness to IL-8 was assessed using micro Boyden chambers. RESULTS--Sixteen infants developed IRDS and, of these, 10 infants subsequently developed chronic lung disease. Levels of IL-8 in BLF at 14 days of age correlated with the long term requirement for intermittent positive pressure ventilation (IPPV). Interleukin 8 levels in BLF correlated with neutrophil numbers and MPO concentration, suggesting both recruitment and activation in response to this cytokine. Antibody depletion studies showed that approximately 50% of total neutrophil chemotactic activity in BLF was due to IL-8. No difference in peripheral neutrophil chemotactic responsiveness at any age was observed for infants with IRDS or chronic lung disease. Plasma soluble intercellular adhesion molecule (sICAM-1) was higher at 14 days of age in infants who developed chronic lung disease than in those with resolving IRDS, and correlated with severity of disease, as indicated by duration of IPPV. CONCLUSIONS--The results indicate that high levels of plasma sICAM-1 and IL-8 in BLF at day 14 correlate with the development of chronic lung disease and indicate the severity of disease. PMID:7491556

Manprint Handbook for Nondevelopmental Item (NDI) Acquisition

DTIC Science & Technology

1988-03-01

SUPPORTABILITY SOLDIES WILL AC AJIL SU1PPORT GEItS KILL AC TO PERrORM ALL NAIN- uLE1 10 PE~rORM AE- PENANCE ?ASXS TO $ TAX - pul"RD SUPP*rt tO DANA UNOER...system performance wilt have to be ,on (Skill decay rate )? answvered and evaluated based on Army r rn~jinformation. Whot new skills wll be re*#ird...to soldier--New ASI or MOS--Require increased recruiting difficulties. Training MEPSCAT rating of Very Heavy, impact of new L40S or ASI. AWIlPMENT

Video Analytics Evaluation: Survey of Datasets, Performance Metrics and Approaches

DTIC Science & Technology

2014-09-01

training phase and a fusion of the detector outputs. 6.3.1 Training Techniques 1. Bagging: The basic idea of Bagging is to train multiple classifiers...can reduce more noise interesting points. Person detection and background subtraction methods were used to create hot regions. The hot regions were...detection algorithms are incorporated with MHT to construct one integrated detector /tracker. 6.8 IRDS-CASIA team IRDS-CASIA proposed a method to solve a

Composition of Eocene Ice-Rafted Debris, Central Arctic Ocean

NASA Astrophysics Data System (ADS)

Ramstad, C.; St. John, K.

2007-12-01

IODP Expedition 302 drilled a 400-m sediment record which contains physical evidence of ice-rafting in the Eocene and Neogene in the Arctic (Backman et al., 2006; Moran et al., 2006, St. John, in press). An increase in the terrigenous sand abundance occurs above 246 mcd (~46 Ma), with a flux similar to that in the Neogene. Higher resolution sampling in an interval of good recovery from 246-236 mcd shows evidence of cyclic input of IRD and biogenic components that fits with Milankovitch forcing at the obliquity period (Sangiorgi et al., in press). The question remains - what areas of the Arctic were ice-covered at this early stage in the Cenozoic? To address this provenance issue the composition of the terrigenous sands (250 micron fraction) in cores 55-56X is being quantified. Grains in 75 samples are being point-counted and their compositions categorized. Quartz grains are the dominant component (greater than 10,000 grains per gram), with some being hematite-stained, and there are lesser amounts of mafic minerals. No carbonate grains are identified so far in this study. Possible sources areas for Eocene IRD are the Eastern European and Russian Arctic margins. Tracking compositional variations of the IRD over the interval of cyclic deposition, should indicate whether the cyclic IRD deposition was consistently derived from one source region or multiple regions during this time.

An Overview of DoD Policy for and Administration of Independent Research and Development

DTIC Science & Technology

1975-05-01

Anderson, Captain William J. Lewandowski, Major James C . Roan, and Mr. Lloyd G. Mitchell to mention a few) kept the author abreast the latest...D Cost Principles (1959) A-I B. AEC Cost Principles for IR&D B-I C . Section 203, Public Law 91-441 C -i D. DOD IR&D Cost Principles (1971) D-1 E...Arii~bd Services Pkocurement Regulations ASRSC Armed Services Research Specialists Cotiitiiittee BOB Buireau bf the Budgse C Comptroiler CITE

Study report recommendations for the next generation Range Safety System (RSS) Integrated Receiver/Decoder (IRD)

NASA Technical Reports Server (NTRS)

Crosby, Robert H.

1992-01-01

The Integrated Receiver/Decoder (IRD) currently used on the Space Shuttle was designed in the 1980 and prior time frame. Over the past 12 years, several parts have become obsolete or difficult to obtain. As directed by the Marshall Space Flight Center, a primary objective is to investigate updating the IRD design using the latest technology subsystems. To take advantage of experience with the current designs, an analysis of failures and a review of discrepancy reports, material review board actions, scrap, etc. are given. A recommended new design designated as the Advanced Receiver/Decoder (ARD) is presented. This design uses the latest technology components to simplify circuits, improve performance, reduce size and cost, and improve reliability. A self-test command is recommended that can improve and simplify operational procedures. Here, the new design is contrasted with the old. Possible simplification of the total Range Safety System is discussed, as is a single-step crypto technique that can improve and simplify operational procedures.

Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development.

PubMed

Enkhmandakh, Badam; Makeyev, Aleksandr V; Erdenechimeg, Lkhamsuren; Ruddle, Frank H; Chimge, Nyam-Osor; Tussie-Luna, Maria Isabel; Roy, Ananda L; Bayarsaihan, Dashzeveg

2009-01-06

GTF2I and GTF2IRD1 encoding the multifunctional transcription factors TFII-I and BEN are clustered at the 7q11.23 region hemizygously deleted in Williams-Beuren syndrome (WBS), a complex multisystemic neurodevelopmental disorder. Although the biochemical properties of TFII-I family transcription factors have been studied in depth, little is known about the specialized contributions of these factors in pathways required for proper embryonic development. Here, we show that homozygous loss of either Gtf2ird1 or Gtf2i function results in multiple phenotypic manifestations, including embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects in mice. Further analyses suggest that embryonic lethality may be attributable to defects in yolk sac vasculogenesis and angiogenesis. Microarray data indicate that the Gtf2ird1 homozygous phenotype is mainly caused by an impairment of the genes involved in the TGFbetaRII/Alk1/Smad5 signal transduction pathway. The effect of Gtf2i inactivation on this pathway is less prominent, but downregulation of the endothelial growth factor receptor-2 gene, resulting in the deterioration of vascular signaling, most likely exacerbates the severity of the Gtf2i mutant phenotype. A subset of Gtf2ird1 and Gtf2i heterozygotes displayed microcephaly, retarded growth, and skeletal and craniofacial defects, therefore showing that haploinsufficiency of TFII-I proteins causes various developmental anomalies that are often associated with WBS.

A Meta-Analysis of Single-Subject Research on Behavioral Momentum to Enhance Success in Students with Autism.

PubMed

Cowan, Richard J; Abel, Leah; Candel, Lindsay

2017-05-01

We conducted a meta-analysis of single-subject research studies investigating the effectiveness of antecedent strategies grounded in behavioral momentum for improving compliance and on-task performance for students with autism. First, we assessed the research rigor of those studies meeting our inclusionary criteria. Next, in order to apply a universal metric to help determine the effectiveness of this category of antecedent strategies investigated via single-subject research methods, we calculated effect sizes via omnibus improvement rate differences (IRDs). Outcomes provide additional support for behavioral momentum, especially interventions incorporating the high-probability command sequence. Implications for research and practice are discussed, including the consideration of how single-subject research is systematically reviewed to assess the rigor of studies and assist in determining overall intervention effectiveness .

IMPROVEMENTS IN THE THERMAL NEUTRON CALIBRATION UNIT, TNF2, AT LNMRI/IRD.

PubMed

Astuto, A; Fernandes, S S; Patrão, K C S; Fonseca, E S; Pereira, W W; Lopes, R T

2018-02-21

The standard thermal neutron flux unit, TNF2, in the Brazilian National Ionizing Radiation Metrology Laboratory was rebuilt. Fluence is still achieved by moderating of four 241Am-Be sources with 0.6 TBq each. The facility was again simulated and redesigned with graphite core and paraffin added graphite blocks surrounding it. Simulations using the MCNPX code on different geometric arrangements of moderator materials and neutron sources were performed. The resulting neutron fluence quality in terms of intensity, spectrum and cadmium ratio was evaluated. After this step, the system was assembled based on the results obtained from the simulations and measurements were performed with equipment existing in LNMRI/IRD and by simulated equipment. This work focuses on the characterization of a central chamber point and external points around the TNF2 in terms of neutron spectrum, fluence and ambient dose equivalent, H*(10). This system was validated with spectra measurements, fluence and H*(10) to ensure traceability.

The DOD-NASA Independent Research and Development Program: Issues and Methodology for an In-Depth Study

DTIC Science & Technology

1981-01-01

for the expenses of certain indep endently chosen R&D projects judged relevant to military needs. These "in- dependent R&D" (IR&D) expenses are...system’s features, from accounting procedures to the system’s fundamental propriety. The Committee on Indep - endent Research and Development Issues...Patent Policy • • • • • • • • • Accountability and Management A SUGGESTED METHODOLOGY FOR A STUDY OF THE ROLE OF IR&D IN DEFENSE AND SPACE

Geant4 simulation of ion chambers response to 60Co spectrum of LNMRI/IRD Shepherd 81-14D Radiator

NASA Astrophysics Data System (ADS)

Queiroz Filho, P. P.; Da Silva, C. N. M.

2018-03-01

The National Ionizing Radiation Metrology Laboratory of the Radioprotection and Dosimetry Institute (LNMRI / IRD) has recently acquired a Shepherd 81-14D Radiator. In this work we simulate, using Geant4, the behavior with the inverse square law radiation for 3 models of PTW spherical chambers used in radioprotection, a relevant information to planning the measurements. We did the corrections for the attenuation and scattering in the air for each distance, where we used the 60Co spectrum simulated previously.

Productivity: Effects of Information Feedback on Human Errors.

DTIC Science & Technology

1980-07-31

even with 8, 9, and 10 digits. Individual differ- ences were considerable, with a biochemistry technician and a super- market checkout clerk doing...two part ic i pant -, took part Iii t I N t uN , in d a t h Ird part I I ilt I il was planned. [or cachi part ic ilpant , there Where- nline one

An atypical 7q11.23 deletion in a normal IQ Williams–Beuren syndrome patient

PubMed Central

Ferrero, Giovanni Battista; Howald, Cédric; Micale, Lucia; Biamino, Elisa; Augello, Bartolomeo; Fusco, Carmela; Turturo, Maria Giuseppina; Forzano, Serena; Reymond, Alexandre; Merla, Giuseppe

2010-01-01

Williams–Beuren syndrome (WBS; OMIM no. 194050) is a multisystemic neurodevelopmental disorder caused by a hemizygous deletion of 1.55 Mb on chromosome 7q11.23 spanning 28 genes. Haploinsufficiency of the ELN gene was shown to be responsible for supravalvular aortic stenosis and generalized arteriopathy, whereas LIMK1, CLIP2, GTF2IRD1 and GTF2I genes were suggested to be linked to the specific cognitive profile and craniofacial features. These insights for genotype–phenotype correlations came from the molecular and clinical analysis of patients with atypical deletions and mice models. Here we report a patient showing mild WBS physical phenotype and normal IQ, who carries a shorter 1 Mb atypical deletion. This rearrangement does not include the GTF2IRD1 and GTF2I genes and only partially the BAZ1B gene. Our results are consistent with the hypothesis that hemizygosity of the GTF2IRD1 and GTF2I genes might be involved in the facial dysmorphisms and in the specific motor and cognitive deficits observed in WBS patients. PMID:19568270

Origin of ice-rafted debris: Pleistocene paleoceanography in the western Arctic Ocean

NASA Astrophysics Data System (ADS)

Bischof, Jens; Clark, David L.; Vincent, Jean-Serge

1996-12-01

The composition of Pleistocene ice-rafted debris (IRD) >250 µm was analyzed quantitatively by grain counting in five sediment cores from the western central Arctic Ocean and compared with the composition of till clasts from NW Canada in order to determine the dropstone origin and to reconstruct the Pleistocene ice driftways and surface currents. The IRD composition alternates repeatedly between carbonate- and quartz-dominated assemblages, along with metamorphic and igneous rocks, clastic rocks, and some chert. The highest quartz content is found on the Alpha Ridge, while carbonate percentages are highest on the Northwind Ridge (NWR) and the Chukchi Cap. The source for the carbonates is the area around Banks and Victoria Islands and parts of northern Canada. Quartz most likely originated from the central Queen Elizabeth Islands. IRD on the southeastern Alpha Ridge is dominated by mafic crystalline rocks from northern Ellesmere Island and northern Greenland. At least six major glacial intervals are identified within the last 1 million years, during which icebergs drifted toward the west in the Beaufort Sea, straight northward in the central Arctic Ocean, and northeastward on the SE Alpha Ridge.

Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination.

PubMed

Coppieters, Frauke; Ascari, Giulia; Dannhausen, Katharina; Nikopoulos, Konstantinos; Peelman, Frank; Karlstetter, Marcus; Xu, Mingchu; Brachet, Cécile; Meunier, Isabelle; Tsilimbaris, Miltiadis K; Tsika, Chrysanthi; Blazaki, Styliani V; Vergult, Sarah; Farinelli, Pietro; Van Laethem, Thalia; Bauwens, Miriam; De Bruyne, Marieke; Chen, Rui; Langmann, Thomas; Sui, Ruifang; Meire, Françoise; Rivolta, Carlo; Hamel, Christian P; Leroy, Bart P; De Baere, Elfride

2016-08-04

Inherited retinal dystrophies (iRDs) are a group of genetically and clinically heterogeneous conditions resulting from mutations in over 250 genes. Here, homozygosity mapping and whole-exome sequencing (WES) in a consanguineous family revealed a homozygous missense mutation, c.973C>T (p.His325Tyr), in RCBTB1. In affected individuals, it was found to segregate with retinitis pigmentosa (RP), goiter, primary ovarian insufficiency, and mild intellectual disability. Subsequent analysis of WES data in different cohorts uncovered four additional homozygous missense mutations in five unrelated families in whom iRD segregates with or without syndromic features. Ocular phenotypes ranged from typical RP starting in the second decade to chorioretinal dystrophy with a later age of onset. The five missense mutations affect highly conserved residues either in the sixth repeat of the RCC1 domain or in the BTB1 domain. A founder haplotype was identified for mutation c.919G>A (p.Val307Met), occurring in two families of Mediterranean origin. We showed ubiquitous mRNA expression of RCBTB1 and demonstrated predominant RCBTB1 localization in human inner retina. RCBTB1 was very recently shown to be involved in ubiquitination, more specifically as a CUL3 substrate adaptor. Therefore, the effect on different components of the CUL3 and NFE2L2 (NRF2) pathway was assessed in affected individuals' lymphocytes, revealing decreased mRNA expression of NFE2L2 and several NFE2L2 target genes. In conclusion, our study puts forward mutations in RCBTB1 as a cause of autosomal-recessive non-syndromic and syndromic iRD. Finally, our data support a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations. Copyright © 2016 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study.

PubMed

Durand, Christine M; Bowring, Mary G; Thomas, Alvin G; Kucirka, Lauren M; Massie, Allan B; Cameron, Andrew; Desai, Niraj M; Sulkowski, Mark; Segev, Dorry L

2018-05-15

The epidemic of drug overdose deaths in the United States has led to an increase in organ donors. To characterize donors who died of overdose and to analyze outcomes among transplant recipients. Prospective observational cohort study. Scientific Registry of Transplant Recipients, 1 January 2000 to 1 September 2017. 138 565 deceased donors; 337 934 transplant recipients at 297 transplant centers. The primary exposure was donor mechanism of death (overdose-death donor [ODD], trauma-death donor [TDD], or medical-death donor [MDD]). Patient and graft survival and organ discard (organ recovered but not transplanted) were compared using propensity score-weighted standardized risk differences (sRDs). A total of 7313 ODDs and 19 897 ODD transplants (10 347 kidneys, 5707 livers, 2471 hearts, and 1372 lungs) were identified. Overdose-death donors accounted for 1.1% of donors in 2000 and 13.4% in 2017. They were more likely to be white (85.1%), aged 21 to 40 years (66.3%), infected with hepatitis C virus (HCV) (18.3%), and increased-infectious risk donors (IRDs) (56.4%). Standardized 5-year patient survival was similar for ODD organ recipients compared with TDD organ recipients (sRDs ranged from 3.1% lower to 3.9% higher survival) and MDD organ recipients (sRDs ranged from 2.1% to 5.2% higher survival). Standardized 5-year graft survival was similar between ODD and TDD grafts (minimal difference for kidneys and lungs, marginally lower [sRD, -3.2%] for livers, and marginally higher [sRD, 1.9%] for hearts). Kidney discard was higher for ODDs than TDDs (sRD, 5.2%) or MDDs (sRD, 1.5%); standardization for HCV and IRD status attenuated this difference. Inability to distinguish between opioid and nonopioid overdoses. In the United States, transplantation with ODD organs has increased dramatically, with noninferior outcomes in transplant recipients. Concerns about IRD behaviors and hepatitis C among donors lead to excess discard that should be minimized given the current organ shortage. National Institutes of Health.

Unravelling the genetic basis of simplex Retinitis Pigmentosa cases

PubMed Central

Bravo-Gil, Nereida; González-del Pozo, María; Martín-Sánchez, Marta; Méndez-Vidal, Cristina; Rodríguez-de la Rúa, Enrique; Borrego, Salud; Antiñolo, Guillermo

2017-01-01

Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and genetic heterogeneity, RP can be inherited as an autosomal dominant (ad), autosomal recessive (ar) and X-linked (xl) disorder. Although the relative prevalence of each form varies somewhat between populations, a major proportion (41% in Spain) of patients represent simplex cases (sRP) in which the mode of inheritance is unknown. Molecular genetic diagnostic is crucial, but also challenging, for sRP patients because any of the 81 RP genes identified to date may be causative. Herein, we report the use of a customized targeted gene panel consisting of 68 IRD genes for the molecular characterization of 106 sRP cases. The diagnostic rate was 62.26% (66 of 106) with a proportion of clinical refinements of 30.3%, demonstrating the high efficiency of this genomic approach even for clinically ambiguous cases. The high number of patients diagnosed here has allowed us to study in detail the genetic basis of the sRP. The solved sRP cohort is composed of 62.1% of arRP cases, 24.2% of adRP and 13.6% of xlRP, which implies consequences for counselling of patients and families. PMID:28157192

Improvement in vision: a new goal for treatment of hereditary retinal degenerations

PubMed Central

Jacobson, Samuel G; Cideciyan, Artur V; Aguirre, Gustavo D; Roman, Alejandro J; Sumaroka, Alexander; Hauswirth, William W; Palczewski, Krzysztof

2015-01-01

Introduction: Inherited retinal degenerations (IRDs) have long been considered untreatable and incurable. Recently, one form of early-onset autosomal recessive IRD, Leber congenital amaurosis (LCA) caused by mutations in RPE65 (retinal pigment epithelium-specific protein 65 kDa) gene, has responded with some improvement of vision to gene augmentation therapy and oral retinoid administration. This early success now requires refinement of such therapeutics to fully realize the impact of these major scientific and clinical advances. Areas covered: Progress toward human therapy for RPE65-LCA is detailed from the understanding of molecular mechanisms to preclinical proof-of-concept research to clinical trials. Unexpected positive and complicating results in the patients receiving treatment are explained. Logical next steps to advance the clinical value of the therapeutics are suggested. Expert opinion: The first molecularly based early-phase therapies for an IRD are remarkably successful in that vision has improved and adverse events are mainly associated with surgical delivery to the subretinal space. Yet, there are features of the gene augmentation therapeutic response, such as slowed kinetics of night vision, lack of foveal cone function improvement and relentlessly progressive retinal degeneration despite therapy, that still require research attention. PMID:26246977

A systematic review of training programs for parents of children with autism spectrum disorders: single subject contributions.

PubMed

Patterson, Stephanie Y; Smith, Veronica; Mirenda, Pat

2012-09-01

The purpose of this systematic review was to examine research utilizing single subject research designs (SSRD) to explore the effectiveness of interventions designed to increase parents' ability to support communication and social development in children with autism spectrum disorders (ASDs). Included studies were systematically assessed for methodological quality (Logan et al., 2008; Smith et al., 2007) and intervention effects. Data examining participant characteristics, study methodology, outcomes, and analysis were systematically extracted. Eleven SSRD parent-training intervention studies examining 44 participants with ASD were included. Overall, the studies were of moderate quality and reported increases in parent skills and child language and communication outcomes. The results supported by improvement rate difference (IRD) analysis indicated several interventions demonstrated positive effects for both parent and child outcomes. However, limited generalization and follow-up data suggested only one intervention demonstrated parents' accurate and ongoing intervention implementation beyond training.

IRD dropout study

NASA Technical Reports Server (NTRS)

Yalowitz, Jeffrey S.; Schroer, Michael A.; Dickson, John E., Jr.

1992-01-01

This final report describes work performed by SRS Technologies for the NASA Marshall Space Flight Center under Contract NAS8-39077, entitled 'Integrated Receiver-Decoder Dropout Study'. The purpose of the study was to determine causes of signal fading effects on ultra-high-frequency (UHF) range safety transmissions to the Space Shuttle during flyout. Of particular interest were deep fades observed at the External Tank (ET) Integrated Receiver-Decoder (IRD) during the flyout interval between solid rocket booster separation and ET separation. Analytical and simulation methods were employed in this study to assess observations captured in flight telemetry data records. Conclusions based on the study are presented in this report, and recommendations are given for future experimental validation of the results.

A methodology to evaluate occupational internal exposure to fluorine-18.

PubMed

Oliveira, C M; Dantas, A L A; Dantas, B M

2009-11-15

The objective of this work is to develop procedures for internal monitoring of (18)F to be applied in cases of possible incorporation of fluoride and (18)FDG, using in vivo and in vitro methods of measurements. The Na I (Tl) 8" x 4" scintillation detector installed at IRD-Whole Body Counter was calibrated for measurements with a whole body anthropomorphic phantom, simulating homogeneous distribution of (18)F in the body. The NaI(Tl) 3"x 3" scintillation detector installed at the IRD-Whole Body Counter was calibrated for in vivo measurements with a brain phantom inserted in an artificial skull, simulating (18)FDG incorporation. The HPGe detection system installed at the IRD-Bioassay Laboratory was calibrated for in vitro measurements of urine samples with 1 liter plastic bottles containing a standard liquid source. A methodology for bioassay data interpretation, based on standard ICRP models edited with the software AIDE-version 6, was established. It is concluded that in vivo measurements have sufficient sensitivity for monitoring (18)F in the forms of fluoride and (18)FDG. The use of both in vitro and in vivo bioassay data can provide useful information for the interpretation of bioassay data in cases of accidental incorporation in order to identify the chemical form of (18)F incorporated.

Transport of 137Cs and 239,240Pu with ice-rafted debris in the Arctic Ocean

USGS Publications Warehouse

Landa, E.R.; Reimnitz, E.; Beals, D.M.; Pochkowski, J.M.; Winn, W.G.; Rigor, I.

1998-01-01

Ice rafting is the dominant mechanism responsible for the transport of fine-grained sediments from coastal zones to the deep Arctic Basin. Therefore, the drift of ice-rafted debris (IRD) could be a significant transport mechanism from the shelf to the deep basin for radionuclides originating from nuclear fuel cycle activities and released to coastal Arctic regions of the former Soviet Union. In this study, 28 samples of IRD collected from the Arctic ice pack during expeditions in 1989-95 were analyzed for 137Cs by gamma spectrometry and for 239Pu and 240Pu by thermal ionization mass spectrometry. 137Cs concentrations in the IRD ranged from less than 0.2 to 78 Bq??kg-1 (dry weight basis). The two samples with the highest 137Cs concentrations were collected in the vicinity of Franz Josef Land, and their backward trajectories suggest origins in the Kara Sea. Among the lowest 137Cs values are seven measured on sediments entrained on the North American shelf in 1989 and 1995, and sampled on the shelf less than six months later. Concentrations of 239Pu + 240Pu ranged from about 0.02 to 1.8 Bq??kg-1. The two highest values came from samples collected in the central Canada Basin and near Spitsbergen; calculated backward trajectories suggest at least 14 years of circulation in the Canada Basin in the former case, and an origin near Severnaya Zemlya (at the Kara Sea/Laptev Sea boundary) in the latter case. While most of the IRD samples showed 240Pu/239Pu ratios near the mean global fallout value of 0.185, five of the samples had lower ratios, in the 0.119 to 0.166 range, indicative of mixtures of Pu from fallout and from the reprocessing of weapons-grade Pu. The backward trajectories of these five samples suggest origins in the Kara Sea or near Severnaya Zemlya.

Development of Refractive Errors-What Can We Learn From Inherited Retinal Dystrophies?

PubMed

Hendriks, Michelle; Verhoeven, Virginie J M; Buitendijk, Gabriëlle H S; Polling, Jan Roelof; Meester-Smoor, Magda A; Hofman, Albert; Kamermans, Maarten; Ingeborgh van den Born, L; Klaver, Caroline C W

2017-10-01

It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene, and refractive error in IRDs may provide insight herein. Case-control study. Study Population: Total of 302 patients with IRD from 2 ophthalmogenetic centers in the Netherlands. Reference Population: Population-based Rotterdam Study-III and Erasmus Rucphen Family Study (N = 5550). Distributions and mean spherical equivalent (SE) were calculated for main affected cell type and causal gene; and risks of myopia and hyperopia were evaluated using logistic regression. Bipolar cell-related dystrophies were associated with the highest risk of SE high myopia 239.7; odds ratio (OR) mild hyperopia 263.2, both P < .0001; SE -6.86 diopters (D) (standard deviation [SD] 6.38), followed by cone-dominated dystrophies (OR high myopia 19.5, P < .0001; OR high hyperopia 10.7, P = .033; SE -3.10 D [SD 4.49]); rod dominated dystrophies (OR high myopia 10.1, P < .0001; OR high hyperopia 9.7, P = .001; SE -2.27 D [SD 4.65]), and retinal pigment epithelium (RPE)-related dystrophies (OR low myopia 2.7; P = .001; OR high hyperopia 5.8; P = .025; SE -0.10 D [SD 3.09]). Mutations in RPGR (SE -7.63 D [SD 3.31]) and CACNA1F (SE -5.33 D [SD 3.10]) coincided with the highest degree of myopia and in CABP4 (SE 4.81 D [SD 0.35]) with the highest degree of hyperopia. Refractive errors, in particular myopia, are common in IRD. The bipolar synapse and the inner and outer segments of the photoreceptor may serve as critical sites for myopia development. Copyright © 2017 Elsevier Inc. All rights reserved.

ATP-binding cassette subfamily A, member 4 intronic variants c.4773+3A>G and c.5461-10T>C cause Stargardt disease due to defective splicing.

PubMed

Jonsson, Frida; Westin, Ida Maria; Österman, Lennart; Sandgren, Ola; Burstedt, Marie; Holmberg, Monica; Golovleva, Irina

2018-02-20

Inherited retinal dystrophies (IRDs) represent a group of progressive conditions affecting the retina. There is a great genetic heterogeneity causing IRDs, and to date, more than 260 genes are associated with IRDs. Stargardt disease, type 1 (STGD1) or macular degeneration with flecks, STGD1 represents a disease with early onset, central visual impairment, frequent appearance of yellowish flecks and mutations in the ATP-binding cassette subfamily A, member 4 (ABCA4) gene. A large number of intronic sequence variants in ABCA4 have been considered pathogenic although their functional effect was seldom demonstrated. In this study, we aimed to reveal how intronic variants present in patients with Stargardt from the same Swedish family affect splicing. The splicing of the ABCA4 gene was studied in human embryonic kidney cells, HEK293T, and in human retinal pigment epithelium cells, ARPE-19, using a minigene system containing variants c.4773+3A>G and c.5461-10T>C. We showed that both ABCA4 variants, c.4773+3A>G and c.5461-10T>C, cause aberrant splicing of the ABCA4 minigene resulting in exon skipping. We also demonstrated that splicing of ABCA4 has different outcomes depending on transfected cell type. Two intronic variants c.4773+3A>G and c.5461-10T>C, both predicted to affect splicing, are indeed disease-causing mutations due to skipping of exons 33, 34, 39 and 40 of ABCA4 gene. The experimental proof that ABCA4 mutations in STGD patients affect protein function is crucial for their inclusion to future clinical trials; therefore, functional testing of all ABCA4 intronic variants associated with Stargardt disease by minigene technology is desirable. © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Deglacial hydrography and IRD inputs: A comparison of Terminations I and II in the N.E. Atlantic

NASA Astrophysics Data System (ADS)

Hibbert, Fiona; Chapman, Mark; Austin, William; Rohling, Eelco

2015-04-01

We present a high resolution marine record (MD04-2822) from the N.E. Atlantic. This record captures the demise of the penultimate glaciation (Termination II) in high resolution. The record of co-registered proxies offers the opportunity to investigate the evolution of the last two deglacial events in the North Atlantic. The deglacial evolution of Termination II is much less well documented than the last deglaciation (Termination I). A striking feature of Termination II in the MD04-2822 record, are several large (~1 ‰) oscillations in benthic δ18O, reflecting oscillations in sea level (e.g. Grant et al., 2012, Thomas et al., 2009) and/or deep sea temperatures (cf. Skinner and Shackleton, 2006). Also notable is the markedly different pattern of surface and deep water evolution for the two deglaciations. Termination I is characterised by a short offset between benthic δ18O decrease and δ13C increase (and northwards migration of the polar front) whereas during Termination II, benthic δ13C 'improvement' (and inferred resumption in overturning) occurs only during the Marine Isotope Stage (MIS) 5e plateau, giving the marine record it's characteristic 'drawn-out' appearance. The most conspicuous feature of the penultimate deglacial in most marine cores is Heinrich event 11 (H11), an extensive episode of ice rafted debris (IRD) discharge that spread across the North Atlantic to the margin of what is now the subtropical gyre (Chapman et al., 2000). H11 generally manifests in marine records as one large and long (~ 2.5 ka) event throughout the Termination. In MD04-2822 however, there are multiple IRD events within the Termination. The continued influence of the disintegrating N. hemisphere ice sheets is also evident within the benthic δ13C and surface conditions (the polar front migrates north of the core site early within MIS 5e following a brief SST reversal).

[Plant and soil nutrient characteristics in the karst shrub ecosystem of southwest Hunan, China].

PubMed

Li, Yan Qiong; Deng, Xiang Wen; Yi, Chang Yan; Deng, Dong Hua; Huang, Zhi Hong; Xiang, Wen Hua; Fang, Xi; Jing, Yi Ran

2016-04-22

This research was conducted in light (LRD), moderate (MRD, abandoned land) and intense (IRD) rocky desertification shrub ecosystems in Shaoyang, Hunan Province. We collected plant samples and soil at 3 layers (0-15, 15-30, 30-45 cm), and analyzed the distribution patterns of soil and plant nutrients and the relationships among them. Our results showed that the contents of soil organic carbon (SOC) and total N in different soil layers were various and decreased with soil depth, while the contents of total P, K, Ca and Mg had no obvious variation among the different soil layers. The contents of total N, P, Ca and Mg in soil were significantly different among the 3 rocky desertification shrub ecosystems, and the SOC, total N and total P in MRD were relatively higher than in the others. The rank of macroelement contents in soils for LRD and IRD was SOC>total K>total Ca>total Mg>total N>total P, while it was SOC>total K>total Ca>total N>total Mg>total P for MRD. The rank of macroelement contents in plants from the 3 rocky desertification shrub ecosystems was Ca>N>K>Mg>P, and the contents of N and P in plants were significantly positively correlated with the corresponding contents of total N and total P in soils. Soil nutrients were closely related to vegetation growth. According to the soil nutrient status of desertification plots of different grades, we should integrate the forest reservation with artificial afforestation and targeted fertilization methods for managing karst rocky desertification.

Single-case synthesis tools II: Comparing quantitative outcome measures.

PubMed

Zimmerman, Kathleen N; Pustejovsky, James E; Ledford, Jennifer R; Barton, Erin E; Severini, Katherine E; Lloyd, Blair P

2018-03-07

Varying methods for evaluating the outcomes of single case research designs (SCD) are currently used in reviews and meta-analyses of interventions. Quantitative effect size measures are often presented alongside visual analysis conclusions. Six measures across two classes-overlap measures (percentage non-overlapping data, improvement rate difference, and Tau) and parametric within-case effect sizes (standardized mean difference and log response ratio [increasing and decreasing])-were compared to determine if choice of synthesis method within and across classes impacts conclusions regarding effectiveness. The effectiveness of sensory-based interventions (SBI), a commonly used class of treatments for young children, was evaluated. Separately from evaluations of rigor and quality, authors evaluated behavior change between baseline and SBI conditions. SBI were unlikely to result in positive behavior change across all measures except IRD. However, subgroup analyses resulted in variable conclusions, indicating that the choice of measures for SCD meta-analyses can impact conclusions. Suggestions for using the log response ratio in SCD meta-analyses and considerations for understanding variability in SCD meta-analysis conclusions are discussed. Copyright © 2018 Elsevier Ltd. All rights reserved.

Short Communication: Hyperthyroidism in Human Immunodeficiency Virus Patients on Combined Antiretroviral Therapy: Case Series and Literature Review.

PubMed

Hsu, Emory; Phadke, Varun K; Nguyen, Minh Ly T

2016-06-01

We describe an HIV-infected patient initiated on combined antiretroviral therapy (cART) who subsequently developed immune restoration disease (IRD) hyperthyroidism-this case represents one of five such patients seen at our center within the past year. Similar to previous reports of hyperthyroidism due to IRD, all of our patients experienced a rapid early recovery in total CD4 count, but developed symptoms of hyperthyroidism on average 3 years (38 months) after beginning cART, which represents a longer time frame than previously reported. Awareness and recognition of this potential complication of cART, which may occur years after treatment initiation, will allow patients with immune restorative hyperthyroidism to receive timely therapy and avoid the long-term complications associated with undiagnosed thyroid disease.

Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning.

PubMed

Wang, Zhuo; Camino, Acner; Hagag, Ahmed M; Wang, Jie; Weleber, Richard G; Yang, Paul; Pennesi, Mark E; Huang, David; Li, Dengwang; Jia, Yali

2018-05-01

Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRDs). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in 16 eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected separately by a local active contour routine. The algorithm is implemented on en face images with minimum segmentation requirements, only needing delineation of the Bruch's membrane, thus evading the inaccuracies and technical challenges associated with automatic segmentation of the ellipsoid zone in eyes with severe retinal degeneration. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Comparison of the sonographic features of the abdominal wall muscles and connective tissues in individuals with and without lumbopelvic pain.

PubMed

Whittaker, Jackie L; Warner, Martin B; Stokes, Maria

2013-01-01

Cross-sectional, case-control study. To measure and compare the resting thickness of the 4 abdominal wall muscles, their associated perimuscular connective tissue (PMCT), and interrecti distance (IRD) in persons with and without lumbopelvic pain (LPP), using ultrasound imaging. The muscles and PMCT of the abdominal wall assist in controlling the spine. Functional deficits of the abdominal wall muscles have been detected in populations with LPP. Investigations of the abdominal wall in those with LPP are primarily concerned with muscle, most commonly the transversus abdominis (TrA) and internal oblique (IO). Because the abdominal wall functions as a unit, all 4 abdominal muscles and their associated connective tissues should be considered concurrently. B-mode ultrasound imaging was used to measure the resting thickness of the rectus abdominis (RA), external oblique, IO, and TrA muscles; the PMCT planes; and IRD in 50 male and female subjects, 25 with and 25 without LPP (mean ± SD age, 36.3 ± 9.4 and 46.6 ± 8.0 years, respectively). Univariate correlation analysis was used to identify covariates. Analyses of covariance (ANCOVAs) and the Kruskal-Wallis test (IRD) were used to compare cohorts (α = .05). The LPP cohort had less total abdominal muscle thickness (LPP mean ± SD, 18.9 ± 3.0 mm; control, 20.3 ± 3.0 mm; ANCOVA adjusted for body mass index, P = .03), thicker PMCT (LPP, 5.5 ± 0.2 mm; control, 4.3 ± 0.2 mm; ANCOVA adjusted for body mass index, P = .007), and wider IRD (LPP, 11.5 ± 2.0 mm; control, 8.4 ± 1.8 mm; Kruskal-Wallis, P = .005). Analysis of individual muscle thickness revealed no difference in the external oblique, IO, and TrA, but a thinner RA in the LPP cohort (LPP mean ± SD, 7.8 ± 1.5 mm; control, 9.1 ± 1.2 mm; ANCOVA adjusted for body mass index, P<.001). To our knowledge, this is the first study to investigate the morphological characteristics of all 4 abdominal muscles and PMCT in individuals with LPP. The results suggest that there may be altered loading of the PMCT and linea alba secondary to an altered motor control strategy involving a reduced contribution of the RA. Further, the change in RA and connective tissue morphology may be more evident than changes in external oblique, IO, and TrA thickness in persons with LPP. The causes and functional implications of these changes warrant further investigation, as does the role of the RA muscle in the development and persistence of LPP.

48 CFR 31.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... four areas: (a) basic research, (b) applied research, (c) development, and (d) systems and other... the plan. Independent research and development (IR&D) cost means the cost of effort which is neither...

The Evolution of Northern Hemisphere Glaciation

NASA Astrophysics Data System (ADS)

Wright, J. D.

2001-05-01

For much of the last 50 million years, high-latitude regions remained too warm to allow snow to accumulate and form ice sheets. Shackleton et al. (1984) published a landmark paper correlating the first occurrence of ice-rafted detritus (IRD) observed at Rockall Plateau with a prominent increase in benthic foraminiferal d18O values during the late Pliocene. These late Pliocene to Pleistocene ice sheets were modulated on an orbital frequency and have characterized the global climate over the past 2.6 myr (Shackleton and Opdyke, 1973; Shackleton et al., 1984; Ruddiman, et al., 1986). During the early Pliocene, northern hemisphere glaciation (NHG) variations were less significant (Jansen et al., 1993). Our understanding of the Plio-Pleistocene ice sheet cycles can be viewed from two different perspectives. When viewed from the late Pleistocene, the fundamental question is what changed near the early/late Pliocene boundary to produce the large-scale, glacial-interglacial cycles of the past 2.6 Ma. In contrast, the view from the middle to late Miocene is quite different. Since the pioneering work of Shackleton et al. (1984), the record of NHG has been extended further back in time with drilling in the Norwegian Sea (ODP Leg 104). At Sites 642 and 644, IRD was found throughout the late Miocene and back to ~12 Ma. More recent drilling in the high northern latitudes occurred on ODP Leg 151. Site 909 recovered a middle Miocene section from the Fram Straits with rounded quartz grains that were interpreted as IRD (Wolf-Welling et al., 1996). Age estimates for those sediments place the first northern hemisphere ice sheets at least as old as 14 Ma. The occurrence of sand-sized particles (>1000 μm) and coal below this level indicates the possibility of glacial activity in the Northern Hemisphere as early as 16 Ma. Thus, the late Pliocene to Pleistocene cycles appear to be the resumption of the glacial-interglacial pattern that began during the Miocene. While the Miocene ice sheets were much smaller than their late Pliocene and Pleistocene counterparts, their presence casts the climate dynamics of the Neogene in a new light. Thus, understanding the middle to late Miocene climatic changes is key to understanding the Plio-Pleistocene climates.

An evaluation of serum soluble CD30 levels and serum CD26 (DPPIV) enzyme activity as markers of type 2 and type 1 cytokines in HIV patients receiving highly active antiretroviral therapy

PubMed Central

Keane, N M; Price, P; Lee, S; Stone, S F; French, M A

2001-01-01

This study evaluates serum CD26 (dipeptidyl peptidase IV, DPPIV) enzyme activity and serum levels of soluble CD30 as markers of T1 and T2 cytokine environments in HIV patients who achieved immune reconstitution after highly active antiretroviral therapy (HAART). Patients who had experienced inflammatory disease associated with pre-existent opportunistic infections after HAART (immune restoration diseases, IRD) were considered separately. Serum sCD30 levels and CD26 (DPPIV) enzyme activity were compared with IFN-γ production by PBMC cultured with cytomegalovirus (CMV) antigen in controls and patient groups. High sCD30 levels were associated with low IFN-γ production after antigenic stimulation in control subjects and, to a lesser extent, in immune reconstituted HIV patients. There was no association between serum CD26 (DPPIV) enzyme activity and IFN-γ production or sCD30 levels. Serum sCD30 levels and CD26 (DPPIV) enzyme activity were significantly increased in immune reconstituted patients with high HIV viral loads. Patients who had experienced CMV retinitis as an IRD had significantly higher sCD30 levels than all other patient groups. Hence, high sCD30 levels may be a marker of a T2 cytokine environment in HIV patients with immune reconstitution and are associated with higher HIV viral loads and a history of CMV associated IRD. PMID:11678906

Wave inhibition by sea ice enables trans-Atlantic ice rafting of debris during Heinrich Events

NASA Astrophysics Data System (ADS)

Wagner, T. J. W.; Dell, R.; Eisenman, I.; Keeling, R. F.; Padman, L.; Severinghaus, J. P.

2017-12-01

The thickness of the ice-rafted debris (IRD) layers that signal Heinrich Events declines far more gradually with distance from the iceberg sources than would be expected based on present-day iceberg trajectories. Here we model icebergs as passive Lagrangian tracers driven by ocean currents, winds, and sea surface temperatures. The icebergs are released in a comprehensive climate model simulation of the last glacial maximum (LGM), as well as a simulation of the modern climate. The two simulated climates result in qualitatively similar distributions of iceberg meltwater and hence debris, with the colder temperatures of the LGM having only a relatively small effect on meltwater spread. In both scenarios, meltwater flux falls off rapidly with zonal distance from the source, in contrast with the more uniform spread of IRD in sediment cores. In order to address this discrepancy, we propose a physical mechanism that could have prolonged the lifetime of icebergs during Heinrich events. The mechanism involves a surface layer of cold and fresh meltwater formed from, and retained around, densely packed armadas of icebergs. This leads to wintertime sea ice formation even in relatively low latitudes. The sea ice in turn shields the icebergs from wave erosion, which is the main source of iceberg ablation. We find that allowing sea ice to form around all icebergs during four months each winter causes the model to approximately agree with the distribution of IRD in sediment cores.

New TFII-I family target genes involved in embryonic development.

PubMed

Makeyev, Aleksandr V; Bayarsaihan, Dashzeveg

2009-09-04

Two members of the TFII-I family transcription factor genes, GTF2I and GTF2IRD1, are the prime candidates responsible for the craniofacial and cognitive abnormalities of Williams syndrome patients. We have previously generated mouse lines with targeted disruption of Gtf2i and Gtf2ird1. Microarray analysis revealed significant changes in the expression profile of mutant embryos. Here we described three unknown genes that were dramatically down-regulated in mutants. The 2410018M08Rik/Scand3 gene encodes a protein of unknown function with CHCH and hATC domains. Scand3 is down-regulated during mouse embryonic stem cell (ES) differentiation. 4933436H12Rik is a testis-specific gene, which encodes a protein with no known domains. It is expressed in mouse ES cells. 1110008P08Rik/Kbtbd7 encodes an adapter protein with BTB/POZ, BACK, and Kelch motifs, previously shown to recruit substrates to the enzymatic complexes of the histone modifying or E3 ubiquitin ligase activities. Based on its expression pattern Kbtbd7 may have a specific role in brain development and function. All three genes possess well-conserved TFII-I-binding consensus sites within proximal promoters. Therefore our analysis suggests that these genes can be direct targets of TFII-I proteins and their impaired expression, as a result of the GTF2I and GTF2IRD1 haploinsufficiency, could contribute to the etiology of Williams syndrome.

Andrew integrated reservoir description

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todd, S.P.

1996-12-31

The Andrew field is an oil and gas accumulation in Palaeocene deep marine sands in the Central North Sea. It is currently being developed with mainly horizontal oil producers. Because of the field`s relatively small reserves (mean 118 mmbbls), the performance of each of the 10 or so horizontal wells is highly important. Reservoir description work at sanction time concentrated on supporting the case that the field could be developed commercially with the minimum number of wells. The present Integrated Reservoir Description (IRD) is focussed on delivering the next level of detail that will impact the understanding of the localmore » reservoir architecture and dynamic performance of each well. Highlights of Andrew IRD Include: (1) Use of a Reservoir Uncertainty Statement (RUS) developed at sanction time to focus the descriptive effort of both asset, support and contract petrotechnical staff, (2) High resolution biostratigraphic correlation to support confident zonation of the reservoir, (3) Detailed sedimentological analysis of the core including the use of dipmeter to interpret channel/sheet architecture to provide new insights into reservoir heterogeneity; (4) Integrated petrographical and petrophysical investigation of the controls on Sw-Height and relative permeability of water; (5) Fluids description using oil geochemistry and Residual Salt Analysis Sr isotope studies. Andrew IRD has highlighted several important risks to well performance, including the influence of more heterolithic intervals on gas breakthrough and the controls on water coning exerted by suppressed water relative permeability in the transition zone.« less

Andrew integrated reservoir description

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todd, S.P.

1996-01-01

The Andrew field is an oil and gas accumulation in Palaeocene deep marine sands in the Central North Sea. It is currently being developed with mainly horizontal oil producers. Because of the field's relatively small reserves (mean 118 mmbbls), the performance of each of the 10 or so horizontal wells is highly important. Reservoir description work at sanction time concentrated on supporting the case that the field could be developed commercially with the minimum number of wells. The present Integrated Reservoir Description (IRD) is focussed on delivering the next level of detail that will impact the understanding of the localmore » reservoir architecture and dynamic performance of each well. Highlights of Andrew IRD Include: (1) Use of a Reservoir Uncertainty Statement (RUS) developed at sanction time to focus the descriptive effort of both asset, support and contract petrotechnical staff, (2) High resolution biostratigraphic correlation to support confident zonation of the reservoir, (3) Detailed sedimentological analysis of the core including the use of dipmeter to interpret channel/sheet architecture to provide new insights into reservoir heterogeneity; (4) Integrated petrographical and petrophysical investigation of the controls on Sw-Height and relative permeability of water; (5) Fluids description using oil geochemistry and Residual Salt Analysis Sr isotope studies. Andrew IRD has highlighted several important risks to well performance, including the influence of more heterolithic intervals on gas breakthrough and the controls on water coning exerted by suppressed water relative permeability in the transition zone.« less

Iceberg and meltwater discharge events in the western Arctic Ocean since MIS 5: a comparison of sediment cores off the East Siberian and Chukchi margins

NASA Astrophysics Data System (ADS)

Xiao, W.; Wang, R.; Zhang, T.; Duan, X.; Polyak, L.

2017-12-01

In the Pleistocene the western Arctic Ocean was affected by deglacial discharge events from ice sheets in northern North America as well as the East Siberian and Chukchi margins. Distribution of Ice Rafted Debris (IRD) >250 μm and planktonic foraminiferal N. pachyderma (sin.) (Nps) δ18O and δ13C was compared in CHINARE sediment cores ARC2-M03 (Wang et al., 2013) and ARC3-P37 from the Chukchi Abyssal Plain and Northwind Ridge, respectively, to identify the impacts of icebergs and meltwater on paleoceanographic environments since MIS 5. The IRD is mainly composed of quartz grains and fragments of clastic rocks and detrital carbonates. The carbonates, mostly dolomites characteristic of the Canadian Arctic Archipelago (CAA) provenance, typically anti-correlate with quartz and clastic rocks, indicating different sources such as Chukchi-Alaskan or East Siberian margin. Most of the Nps δ18O depletions correspond to peaks in detrital carbonates, suggesting a strong influence of meltwater from the Laurentide Ice Sheet (LIS) on the western Arctic Ocean. A conspicuous dark gray interval interpreted to represent glacial/deglacial environments of MIS 4/3 age, shows a remarkable depletion in Nps δ13C along with high δ18O values and absence of IRD. This unusual signature may be related to a persistent sea-ice cover and/or high fluxes of terrigenous material with deglacial debris flows. In a younger grey interval corresponding to MIS2, high abundances of quartz and clastic rocks in the Northwind Ridge core ARC3-P37 indicate iceberg discharge from areas other than CAA, such as the Mackenzie LIS lobe or Chukchi-Alaskan margin. The MIS2-Holocene transition is marked by an increase in detrital carbonates co-occurring with Nps δ13C and δ18O depletion (Polyak et al., 2007), indicative of LIS iceberg/meltwater fluxes from the CAA. We note that stable-isotope events in the study area may go unnoticed because of gaps in foraminiferal records related to dissolution and/or adverse conditions for planktonic foraminifers (very low salinities and high turbidity) during deglaciations.

Moderating factors of video-modeling with other as model: a meta-analysis of single-case studies.

PubMed

Mason, Rose A; Ganz, Jennifer B; Parker, Richard I; Burke, Mack D; Camargo, Siglia P

2012-01-01

Video modeling with other as model (VMO) is a more practical method for implementing video-based modeling techniques, such as video self-modeling, which requires significantly more editing. Despite this, identification of contextual factors such as participant characteristics and targeted outcomes that moderate the effectiveness of VMO has not previously been explored. The purpose of this study was to meta-analytically evaluate the evidence base of VMO with individuals with disabilities to determine if participant characteristics and targeted outcomes moderate the effectiveness of the intervention. Findings indicate that VMO is highly effective for participants with autism spectrum disorder (IRD=.83) and moderately effective for participants with developmental disabilities (IRD=.68). However, differential effects are indicated across levels of moderators for diagnoses and targeted outcomes. Implications for practice and future research are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

An overview of autonomous rendezvous and docking system technology development at General Dynamics

NASA Technical Reports Server (NTRS)

Kuenzel, Fred

1991-01-01

The Centaur avionics suite is undergoing a dramatic modernization for the commercial, DoD Atlas and Titan programs. The system has been upgraded to the current state-of-the-art in ring laser gyro inertial sensors and Mil-Std-1750A processor technology. The Cruise Missile avionic system has similarly been evolving for many years. Integration of GPS into both systems has been underway for over five years with a follow-on cruise missile system currently in flight test. Rendezvous and Docking related studies have been conducted for over five years in support of OMV, CTV, and Advanced Upper Stages, as well as several other internal IR&D's. The avionics system and AR&D simulator demonstrated to the SATWG in November 1990 has been upgraded considerably under two IR&D programs in 1991. The Centaur modern avionics system is being flown in block upgrades which started in July of 1990. The Inertial Navigation Unit will fly in November of 1991. The Cruise Missile avionics systems have been fully tested and operationally validated in combat. The integrated AR&D system for space vehicle applications has been under development and testing since 1990. A Joint NASA / GD ARD&L System Test Program is currently being planned to validate several aspects of system performance in three different NASA test facilities in 1992.

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

PubMed Central

Erdal, Erkin; Haider, Syed; Rehwinkel, Jan; Harris, Adrian L.

2017-01-01

Radiotherapy and chemotherapy are effective treatment methods for many types of cancer, but resistance is common. Recent findings indicate that antiviral type I interferon (IFN) signaling is induced by these treatments. However, the underlying mechanisms still need to be elucidated. Expression of a set of IFN-stimulated genes comprises an IFN-related DNA damage resistance signature (IRDS), which correlates strongly with resistance to radiotherapy and chemotherapy across different tumors. Classically, during viral infection, the presence of foreign DNA in the cytoplasm of host cells can initiate type I IFN signaling. Here, we demonstrate that DNA-damaging modalities used during cancer therapy lead to the release of ssDNA fragments from the cell nucleus into the cytosol, engaging this innate immune response. We found that the factors that control DNA end resection during double-strand break repair, including the Bloom syndrome (BLM) helicase and exonuclease 1 (EXO1), play a major role in generating these DNA fragments and that the cytoplasmic 3′–5′ exonuclease Trex1 is required for their degradation. Analysis of mRNA expression profiles in breast tumors demonstrates that those with lower Trex1 and higher BLM and EXO1 expression levels are associated with poor prognosis. Targeting BLM and EXO1 could therefore represent a novel approach for circumventing the IRDS produced in response to cancer therapeutics. PMID:28279982

The response of the Okhotsk Sea environment to the orbital-millennium global climate changes during the Last Glacial Maximum, deglaciation and Holocene

NASA Astrophysics Data System (ADS)

Gorbarenko, Sergey A.; Artemova, Antonina V.; Goldberg, Evgeniy L.; Vasilenko, Yuriy P.

2014-05-01

Reconstruction of regional climate and the Okhotsk Sea (OS) environment for the Last Glacial Maximum (LGM), deglaciation and Holocene was performed on the basis of high-resolution records of ice rafted debris (IRD), СаСО3, opal, total organic carbon (TOС), biogenic Ba (Ba_bio) and redox sensitive element (Mn, Mo) content, and diatom and pollen results of four cores that form a north-southern transect. Age models of the studied cores were earlier established by AMS 14C data, oxygen-isotope chronostratigraphy and tephrochronology. According to received results, since 25 ka the regional climate and OS environmental conditions have changed synchronously with LGM condition, cold Heinrich event 1, Bølling-Allerød (BA) warming, Younger Dryas (YD) cooling and Pre-Boreal (PB) warming recorded in the Greenland ice core, North Atlantic sediment, and China cave stalagmites. Calculation of IRD MAR in sediment of north-south transect cores indicates an increase of sea ice formation several times in the glacial OS as compared to the Late Holocene. Accompanying ice formation, increased brine rejection and the larger potential density of surface water at the north shelf due to a drop of glacial East Asia summer monsoon precipitation and Amur River run off, led to strong enhancement of the role of the OS in glacial North Pacific Intermediate Water (NPIW) formation. The remarkable increase in OS productivity during BA and PB warming was probably related with significant reorganisation of the North Pacific deep water ventilation and nutrient input into the NPIW and OS Intermediate Water (OSIW). Seven Holocene OS millennial cold events based on the elevated values of the detrended IRD stack record over the IRD broad trend in the sediments of the studied cores have occurred synchronously with cold events recorded in the North Atlantic, Greenland ice cores and China cave stalagmites after 9 ka. Diatom production in the OS was mostly controlled by sea ice cover changes and surface water stratification induced by sea-ice melting; therefore significant opal accumulation in sediments of this basin begin from 4 to 6 ka ago simultaneously with a remarkable decrease of sea ice cover.

Freshening of the Labrador Sea as a trigger for Little Ice Age development

NASA Astrophysics Data System (ADS)

Alonso-Garcia, Montserrat; Kleiven, Helga (Kikki) F.; McManus, Jerry F.; Moffa-Sanchez, Paola; Broecker, Wallace S.; Flower, Benjamin P.

2017-04-01

Arctic freshwater discharges to the Labrador Sea from melting glaciers and sea ice can have a large impact on ocean circulation dynamics in the North Atlantic, modifying climate and deep water formation in this region. In this study, we present for the first time a high resolution record of ice rafting in the Labrador Sea over the last millennium to assess the effects of freshwater discharges in this region on ocean circulation and climate. The occurrence of ice-rafted debris (IRD) in the Labrador Sea was studied using sediments from Site GS06-144-03 (57.29° N, 48.37° W; 3432 m water depth). IRD from the fraction 63-150 µm shows particularly high concentrations during the intervals ˜ AD 1000-1100, ˜ 1150-1250, ˜ 1400-1450, ˜ 1650-1700 and ˜ 1750-1800. The first two intervals occurred during the Medieval Climate Anomaly (MCA), whereas the others took place within the Little Ice Age (LIA). Mineralogical identification indicates that the main IRD source during the MCA was SE Greenland. In contrast, the concentration and relative abundance of hematite-stained grains reflects an increase in the contribution of Arctic ice during the LIA. The comparison of our Labrador Sea IRD records with other climate proxies from the subpolar North Atlantic allowed us to propose a sequence of processes that led to the cooling that occurred during the LIA, particularly in the Northern Hemisphere. This study reveals that the warm climate of the MCA may have enhanced iceberg calving along the SE Greenland coast and, as a result, freshened the subpolar gyre (SPG). Consequently, SPG circulation switched to a weaker mode and reduced convection in the Labrador Sea, decreasing its contribution to the North Atlantic deep water formation and, thus, reducing the amount of heat transported to high latitudes. This situation of weak SPG circulation may have made the North Atlantic climate more unstable, inducing a state in which external forcings (e.g. reduced solar irradiance and volcanic eruptions) could easily drive periods of severe cold conditions in Europe and the North Atlantic like the LIA. This analysis indicates that a freshening of the SPG may play a crucial role in the development of cold events during the Holocene, which may be of key importance for predictions about future climate.

Unravelling source regions of ice rafted debris within three NE Atlantic marine sediment cores during the deglacial interval: a multi-proxy approach

NASA Astrophysics Data System (ADS)

Small, David; Hibbert, Fiona; Austin, Bill

2010-05-01

Ice-rafted debris (IRD) within marine sediments of the North Atlantic provide an important archive of glacial activity on adjacent landmasses and attest to the activity of multiple calving ice margins during the last glacial cycle. IRD records therefore provide a means to reconstruct ice sheet dynamics and their interaction with the climate system, providing evidence of both the source of the ice and the location of melting (e.g. Ruddiman, 1977; Bond and Lotti, 1995). The complex interaction of the circum-Atlantic ice sheets and limitations of individual techniques often hinders firm source designations (i.e. IRD may be derived from multiple sources which cannot be differentiated by, for example, visual characterisation). Initial work identified diagnostic grain types that could be attributed to source areas of palaeo ice-sheets (eg: Bond & Lotti 1995) however, for the BIS, "diagnostic" basalt may be derived from sources to the east and west of the cores (Hibbert et al 2009, Scourse et al 2009). We therefore, utilise a multi-proxy approach to investigate the deglacial dynamics of the last British Ice Sheet (BIS) using inter alia lithic characterisation, fluxes of IRD to the core sites, magnetic susceptibility and a magnetic un-mixing model. A novel application of major element geochemistry of garnets contained within ice-rafted debris of the three high resolution marine sediment cores is presented. Garnets can be used to infer provenance (e.g. Oliver 2001) as major element composition may be assigned to specific metamorphic terranes. The IRD present within these cores is believed to be predominantly sourced from the BIS (cf: Knutz et al 2001, Hibbert et al 2009). This assertion is tested through multiple analytical techniques used and replication of records across the Hebridean shelf into the deep ocean. References • Bond, G.C. & Lotti, R., 1995. Iceberg discharges into the North Atlantic on millennial timescales during the last glaciation. Science 267. pp. 1005-1010. • Hibbert, F.D., Austin, W.E.N., Leng, M.J. and Gatliff, R.W., 2009. British Ice Sheet Dynamics inferred from North Atlantice ice-rafted debris records spanning the last 175,000 years. Journal of Quaternary Science. ISSN 0267-8179. • Knutz, P.C., Austin, W.E.N. and Jones, E.J.W., 2001. Millenial-scale depositional cycles related to British Ice Sheet variability and North Atlantic paleocirculation since 45kyr B.P., Barra Fan, U.K. margin. Paleoceanography 16. pp.53-64. • Oliver, G.J.H., 2001. Reconstruction of the Grampian episode in Scotland: it's place in the Caledonian Orogeny. Tectonphysics 332. pp.23-49. • Ruddiman, W.F., 1977. Late Quaternary deposition of ice-rafted sand in the sub-polar North Atlantic (lat 40° to 65°). Geological Society of America Bulletin 88. pp.1813-1821. • Scourse, J.D., Haapaniemi, A.I., Colmenero-Hidalgo, E., Peck, V.L., Hall, I.R., Austin, W.E.N., Knutz, P.C. and Zahn, R., 2009. Growth, dynamics and deglaciation of the last British-Irish Ice Sheet: the deep-sea ice-rafted detritus record. Quaternary Science Reviews 28. pp.3066-3084.

Comparative transcriptomic analysis provides insights into antibacterial mechanisms of Branchiostoma belcheri under Vibrio parahaemolyticus infection.

PubMed

Zhang, Qi-Lin; Zhu, Qian-Hua; Liang, Ming-Zhong; Wang, Feng; Guo, Jun; Deng, Xian-Yu; Chen, Jun-Yuan; Wang, Yu-Jun; Lin, Lian-Bing

2018-05-01

Amphioxus, a basal chordate, is widely considered to be an existing proxy of the invertebrate ancestor of vertebrates, and it exhibits susceptibility to various pathogen infections and pathogenic mimic challenges. Here, in order to understand more clearly its antibacterial mechanisms, we analyzed the ribosomal RNA (rRNA)-depleted transcriptome of Chinese amphioxus (Branchiostoma belcheri) infected with Vibrio parahaemolyticus (V. p.) via next-generation deep sequencing technology (RNA-seq). We identified a total of 3214 differentially expressed genes (DEGs) by comparing V. p.-infected and control transcriptome libraries, including 2219 significantly up-regulated and 995 significantly down-regulated DEGs in V. p.-infected amphioxus. The DEGs with the top 10 most dramatic expression fold changes after V. p. infection, as well as 53 immune-related DEGs (IRDs) belonging to four primary categories of innate immunity were analyzed further. Through gene ontology (GO) and pathway enrichment analysis, DEGs were found to be primarily related to immune processes, apoptosis, catabolic and metabolic processes, binding and enzyme activity, while pathways involving bacterial infection, immune signaling, immune response, cancer, and apoptosis were overrepresented. We validated the RNA-seq results by detecting the expression levels of 10 IRDs using qRT-PCR, and we surveyed the dynamic variation in gene expression for these IRDs at 0, 6, 12, 24, and 48 h after V. p. Subsequently, according to the RNA-seq results, the presence of a primitive Toll-like receptor (TLR)-mediated antibacterial immune signaling pathway was predicted in B. belcheri. This study provides valuable information regarding antibacterial immunity for further research into the evolution of immunity in vertebrates and broadens our understanding of the innate immune response against bacterial invasion in amphioxus. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ice dynamics of Heinrich events: Insights and implications

NASA Astrophysics Data System (ADS)

Alley, R. B.; Parizek, B. R.; Anandakrishnan, S.

2017-12-01

Physical understanding of ice flow provides important constraints on Heinrich (H) events, which in turn provide lessons for ice dynamics and future sea-level change. Iceberg-rafted debris (IRD), the defining feature of H events, is a complex indicator; however, in cold climates with extensive marine-ending ice, increased IRD flux records ice-shelf loss. Ice shelves fed primarily by inflow from grounded ice experience net basal melting, giving sub-ice-sedimentation rather than open-ocean IRD. Ice-shelf loss has been observed recently in response to atmospheric warming increasing surface meltwater that wedged open crevasses (Larsen B), but also by break-off following thinning from warming of waters reaching the grounding line (Jakobshavn). The H events consistently occurred during cold times resulting from reduced North Atlantic overturning circulation ("conveyor"), but as argued by Marcott et al. (PNAS 2011), this was accompanied by delayed warming at grounding-line depths of the Hudson Strait ice stream, the source of the Heinrich layers, implicating oceanic control. As shown in a rich literature, additional considerations involving thermal state of the ice-stream bed, isostasy and probably other processes influenced why some reduced-conveyor events triggered H-events while others did not. Ice shelves, including the inferred Hudson Strait ice shelf, typically exist in high-salinity, cold waters produced by brine rejection from sea-ice formation, which are the coldest abundant waters in the world ocean. Thus, almost any change in air or ocean temperature, winds or currents can remove ice shelves, because "replacement" water masses are typically warmer. And, because ice shelves almost invariably slow flow of non-floating ice into the ocean, climatic perturbations to regions with ice shelves typically lead to sea-level rise, with important implications.

Prevalence and risk factors of diastasis recti abdominis from late pregnancy to 6 months postpartum, and relationship with lumbo-pelvic pain.

PubMed

Fernandes da Mota, Patrícia Gonçalves; Pascoal, Augusto Gil Brites Andrade; Carita, Ana Isabel Andrade Dinis; Bø, Kari

2015-02-01

Diastasis recti abdominis (DRA) is an impairment characterized by a midline separation of the rectus abdominis muscles along the linea alba. It has its onset during pregnancy and the first weeks following childbirth. There is scant knowledge on both prevalence and risk factors for development of the condition. The aim of this study was to investigate the prevalence of DRA at gestational week 35 and three timepoints postpartum, possible risk factors, and the relationship between DRA and lumbo-pelvic pain. Ultrasound images of inter rectus distance (IRD) were recorded in 84 healthy primiparous women, at three locations on the linea alba. The IRD was measured at: gestational week 35 and 6-8, 12-14, and 24-26 weeks postpartum. Diagnosis of DRA was defined as 16 mm at 2 cm below the umbilicus. Independent sample t-test and binary logistic regression was used to assess differences and risk factors in women with and without DRA and women with and without lumbo-pelvic pain. P < 0.05 was considered statistically significant. The prevalence of DRA decreased from 100% at gestational week 35-39% at 6 months postpartum. No statistically significant differences were found in prepregnancy body mass index (BMI), weight gain, baby's birth weight or abdominal circumference between women with and without DRA at 6 months postpartum. Women with DRA at 6 months postpartum were not more likely to report lumbo-pelvic pain than women without DRA. DRA is prevalent at 6 months postpartum, but is not linked with lumbo-pelvic pain. Copyright © 2014 Elsevier Ltd. All rights reserved.

An infrared divergence in the cosmological measure theory and the anthropic reasoning

NASA Astrophysics Data System (ADS)

Yurov, A. V.; Yurov, V. A.; Astashenok, A. V.; Shpilevoi, A. A.

2011-10-01

An anthropic principle has made it possible to answer the difficult question of why the observable value of cosmological constant ( Λ˜10-47 GeV4) is so disconcertingly tiny compared to the predicted value of vacuum energy density ρ SUSY˜1012 GeV4. Unfortunately, there is a darker side to this argument; being combined with the cosmic heat death scenario, it consequently leads to another absurd prediction: the probability of randomly selected observer observing Λ=0 ends up being exactly equal to 1. We shall call this controversy an infrared divergence problem. It is shown that the IRD prediction can be avoided with the help of a singular runaway measure coupled with the calculation of relative Bayesian probabilities by the means of the doomsday argument. Moreover, it is shown that while the IRD problem occurs for the prediction stage of value of Λ, it disappears at the explanatory stage when Λ has already been measured by the observer.

Antarctic ice-rafted detritus (IRD) in the South Atlantic: Indicators of iceshelf dynamics or ocean surface conditions?

USGS Publications Warehouse

Nielsen, Simon H.H.; Hodell, D.A.

2007-01-01

Ocean sediment core TN057-13PC4/ODP1094, from the Atlantic sector of the Southern Ocean, contains elevated lithogenic material in sections representing the last glacial period compared to the Holocene. This ice-rafted detritus is mainly comprised of volcanic glass and ash, but has a significant input of what was previously interpreted as quartz during peak intervals (Kanfoush et al., 2000, 2002). Our analysis of these clear mineral grains indicates that most are plagioclase, and that South Sandwich Islands is the predominant source, similar to that inferred for the volcanic glass (Nielsen et al., in review). In addition, quartz and feldspar with possible Antarctic origin occur in conjunction with postulated episodes of Antarctic deglaciation. We conclude that while sea ice was the dominant ice rafting agent in the Polar Frontal Zone of the South Atlantic during the last glacial period, the Holocene IRD variability may reflect Antarctic ice sheet dynamics.

Independent Research and Development (IR&D): The Challenges Continue

DTIC Science & Technology

2015-04-30

University of Maryland. Dr. Gansler is the director of both the Center for Public Policy and Private Enterprise and the Sloan Biotechnology Industry...www.defenseinnovationmarketplace.mil/about.html Erwin, S. (2015, February 21). Defense R&D: Is the reward worth the risk? National Defense Magazine

[The snakes of Senegal: an annotated species list].

PubMed

Trape, J F; Mané, Y

2002-08-01

Between 1990 and 2001, the laboratory of Paludologie of IRD at Dakar collected over 5,500 snakes from all over Senegal. By studying this collection, an entirely new species was discovered for science and eight new species for Senegal. The presence of many specimens of rare species and the great number of localities from which snakes were collected also allowed us to solve several delicate taxonomic problems and better to specify the biogeography of Senegalese snakes. Currently, the presence in Senegal of at least 55 different species has been established with certainty. The data collected simultaneously on the burden of snakebites for public health shows considerable differences according to geographic area, with populations from south-eastern Senegal being more exposed to the risk of death by snakebite.

Understanding the Function of Genes Involved in Inherited Retinal Degeneration-Insights into the Pathogenesis and Function of C8ORF37

NASA Astrophysics Data System (ADS)

Sharif, Ali Sakawa

Inherited retinal degenerative diseases (IRD) are a group of disorders that lead to progressive deterioration of mainly the photoreceptors. Retinitis pigmentosa (RP) and cone-rod dystrophy (CRD) are two forms of IRDs. RP is the most common form of IRD and is due to rod photoreceptor degeneration followed by cone photoreceptor loss. CRD, on the other hand, is characterized by the loss of cones or the concurrent degeneration of both cones and rods. Both RP and CRD are presently incurable. More than 200 genes have been identified to cause IRDs and the functions of many of these genes remain unclear. Mutations in a novel gene, C8ORF37, were identified to cause recessive, severe, and early-onset RP and CRD. I, therefore, pioneered in characterizing the role of C8ORF37 in the retina. This dissertation is comprised of four chapters that is organized as follows: (1) summary of an ocular disorder (2) a genetic model of a retinal disorder (3) biochemical/proteomic analysis of C8ORF37 (4) potential clinical applications. A summary of ocular disorders is discussed in Chapter 1, with an emphasis on CRD. Chapter 2 focuses on the generation and characterization of C8orf37 mutant mouse models that recapitulate the retinal pathologies observed in human patients. In C8orf37 knockout retinas, the outer segment (OS) was nonuniform, swollen, and wider in width when compared to the controls. Moreover, many OS membrane proteins were reduced in the retina of C8orf37 knockout, including CNGB1 and RDS, proteins essential for OS disc morphogenesis and alignment. Our findings shed new light on the pathogenesis underlying retinal dysfunction and degeneration in C8ORF37-deficient patients. To determine the function of a novel protein, a powerful approach is by identifying its binding partners. In Chapter 3, I discuss GST pull-down using bovine retinal lysates, yeast-two-hybrid, and immunoprecipitation with mouse retinal lysate in order to identify C8ORF37-interacting proteins. Our pull-downs identified KTN1, RAB28, UCHL1, and PSMD14 suggesting that C8ORF37 may have a role in protein homeostasis. Chapter 4 concludes and discusses the impact of generating and characterizing C8orf37 animal models for future studies in understanding photoreceptor function and in the development of therapeutics against retinal degeneration.

134Cs emission probabilities determination by gamma spectrometry

NASA Astrophysics Data System (ADS)

de Almeida, M. C. M.; Poledna, R.; Delgado, J. U.; Silva, R. L.; Araujo, M. T. F.; da Silva, C. J.

2018-03-01

The National Laboratory for Ionizing Radiation Metrology (LNMRI/IRD/CNEN) of Rio de Janeiro performed primary and secondary standardization of different radionuclides reaching satisfactory uncertainties. A solution of 134Cs radionuclide was purchased from commercial supplier to emission probabilities determination of some of its energies. 134Cs is a beta gamma emitter with 754 days of half-life. This radionuclide is used as standard in environmental, water and food control. It is also important to germanium detector calibration. The gamma emission probabilities (Pγ) were determined mainly for some energies of the 134Cs by efficiency curve method and the Pγ absolute uncertainties obtained were below 1% (k=1).

76 FR 11414 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions (DFARS Case... (DFARS) to require contractors to report independent research and development (IR&D) projects generating... the address shown below on or before May 2, 2011, to be considered in the formation of the final rule...

Satellite Instrument Development and Data Analysis

DTIC Science & Technology

1987-09-30

Document (ICD)), the Investigation Requir ments Document (IRD), and the Polici (-; and Requirements (PAR) documents were revised and ,!pdated to reflect the...6 anenhncemnt f snglyionzed Josetyn. I. A., and J. F. Bryson. Jr.. Magalert: August 27, 1978. Synsp. cncd b th shck:and(6)an nhacemnt f sngl ioize

Indian Resource Development. Annual Report, 1983-1984.

ERIC Educational Resources Information Center

New Mexico State Univ., Las Cruces.

With a budget of $210,000 appropriated by the New Mexico State Legislature, the Indian Resource Development (IRD) Program marked its eighth year by continuing to develop a corps of professionally trained American Indians in fields related to natural resource development in New Mexico through college academic education and related practical work…

Improvements in ion reflux: An electrodialytic eluent generation and suppression device for ion chromatography

USDA-ARS?s Scientific Manuscript database

This work describes a membrane based electrodialytic ion reflux device (IRD), which uses water as the pumped phase and integrates isocratic and gradient eluent generation and suppression. The current design incorporates several ion exchange membranes to create discrete chambers for suppression and e...

Innovation in the Defense Acquisition Enterprise

DTIC Science & Technology

2015-12-01

uni- versities in the fields of innovation and entrepreneurship . Many books and articles have been written on innovation, perhaps none more well...partners has been the possible loss of freedom to make their own IR&D invest- ment decisions. That was never my intent . I once ran a major defense

Marine sedimentary provenance evidence for massive discharges of icebergs from the Aurora and Wilkes sub-glacial basins

NASA Astrophysics Data System (ADS)

Pierce, E. L.; Williams, T.; van de Flierdt, T.; Hemming, S. R.; Brachfeld, S. A.; Goldstein, S. L.

2010-12-01

Understanding the evolution of the East Antarctic Ice Sheet (EAIS) is a fundamental goal in the field of paleoclimate today. Given the current and projected state of global warming, it is important to know how an ice sheet that holds over 50 m of sea-level has behaved under warmer conditions in the past. Despite the fact that over 98% of the East Antarctica continent is covered by thick (2.1 km on average) ice, the chronological characterization of glaciogenic detrital hornblende grains has been proven an excellent provenance tool in the investigation of the source areas for ice rafted detritus around Antarctica (Roy et al., 2007, Chem. Geo.). A circum-Antarctica core-top survey of Ar-Ar ages in hornblende grains demonstrates that East Antarctica can be simply divided into several sectors that correspond to modern ice divides and published geochronological evidence from sparse outcrops around the margins of the continent. Williams et al., (2010, EPSL) found evidence in ice rafted detritus layers in ODP Site 1165 from the Wilde drift off Prydz Bay for large discharges of icebergs from the Adélie and Wilkes Land coasts occurring during the late Miocene and early Pliocene. Sourcing from the Adélie and Wilkes Land coasts requires iceberg transport more than 1500 km around the Antarctic perimeter, and this is therefore evidence for massive discharges of icebergs from these sectors. In the Aurora and Wilkes Basins in these sectors, the ice sheet is grounded well below sea level, and is therefore thought to be potentially unstable under warmer conditions. Such long distant transport of sediments with distinctive sources is reminiscent of Heinrich Events in the North Atlantic. A model often invoked as the cause of these events is the collapse and retreat of ice-streams, which leads to massive discharges of icebergs, laden with sediment, into the ocean. The importance of this interpretation, if true, has led us to make more detailed studies of Quaternary sediments from the Adélie and Wilkes Land coasts as well as glaciogenic sediments throughout the Cenozoic in Prydz Bay. We will present Ar-Ar ages of detrital hornblende and biotite grains (>150 µm), as well as epsilon-Nd values measured on the terrigenous fine fraction (<63 µm), from 9 marine sediment cores along the Adélie and Wilkes Land coasts of East Antarctica (95° to 165°E), and compare them and proximal Prydz Bay data with IRD layers in ODP Site 1165. We have also compared the Ar-Ar biotite age populations from the same IRD layers in ODP site 1165 that Williams et al., (2010, EPSL) examined to explore the use of Ar-Ar biotite ages as a tracer of IRD; given the high K content in biotite, it may be possible to use the 63-150 µm fraction for provenance studies which may be particularly useful for tracing sources of IRD into the Southern Ocean where IRD abundances are low and thus grain sizes tend to be finer. The combined application of these tracers will allow interpretation of the average crust formation age of the sources, as well as provide information on major tectonothermal pulses and cooling through approximately 300°C.

48 CFR 45.303 - Use of Government property on independent research and development programs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Authorizing the Use... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Use of Government property... research and development (IR&D) program, if— (a) Such use will not conflict with the primary use of the...

48 CFR 45.303 - Use of Government property on independent research and development programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Authorizing the Use... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Use of Government property... research and development (IR&D) program, if— (a) Such use will not conflict with the primary use of the...

2011 Special Operations Forces Industry Conference

DTIC Science & Technology

2011-05-19

to USSOCOM acquisition objectives and challenges . The Forum is designed to be an informative discussion, with audience participation, between... Challenge UNCLASSIFIED UNCLAS IF ED UNCLASSIFIED UNCLASSIFIED Acquisition Enterprise DOD and Service Labs, International Partners, Industry IR&D SOF...Experimentation • Mission – Support Concept & Solution Development for SOF Capability Gaps, Technology Thrust Areas & Warfighter Challenges • Objectives

12 CFR 229.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... bank; and (4) Provided to a customer of the bank or acquired from the bank for remittance purposes. (j... Standard Specifications for an Image Replacement Document—IRD, X9.100-140 (hereinafter ANS X9.100-140) for... means a paper reproduction of an original check that— (1) Contains an image of the front and back of the...

12 CFR 229.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... bank; and (4) Provided to a customer of the bank or acquired from the bank for remittance purposes. (j... Standard Specifications for an Image Replacement Document—IRD, X9.100-140 (hereinafter ANS X9.100-140) for... means a paper reproduction of an original check that— (1) Contains an image of the front and back of the...

12 CFR 229.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... bank; and (4) Provided to a customer of the bank or acquired from the bank for remittance purposes. (j... Standard Specifications for an Image Replacement Document—IRD, X9.100-140 (hereinafter ANS X9.100-140) for... means a paper reproduction of an original check that— (1) Contains an image of the front and back of the...

12 CFR 229.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... bank; and (4) Provided to a customer of the bank or acquired from the bank for remittance purposes. (j... Standard Specifications for an Image Replacement Document—IRD, X9.100-140 (hereinafter ANS X9.100-140) for... means a paper reproduction of an original check that— (1) Contains an image of the front and back of the...

12 CFR 229.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... bank; and (4) Provided to a customer of the bank or acquired from the bank for remittance purposes. (j... Standard Specifications for an Image Replacement Document—IRD, X9.100-140 (hereinafter ANS X9.100-140) for... means a paper reproduction of an original check that— (1) Contains an image of the front and back of the...

Symposium Proceedings: Environmental Aspects of Fuel ...

EPA Pesticide Factsheets

... uU, ... • ird • A N IIw — • II- flo t IAW IV — 1 • N •PI * A IF Y & -S- ~^ n? i — i • t< • T •~ • IE L A •^ -A ~ * IY a f- — ^ • U - Figure r-^ ~- _H | 1 — i, N - w 4/5 ...

Novel Phenotype Issues Raised in Cross-National Epidemiological Research on Drug Dependence

PubMed Central

Anthony, James C.

2010-01-01

Stage-transition models based on the American Diagnostic and Statistical Manual (DSM) generally are applied in epidemiology and genetics research on drug dependence syndromes associated with cannabis, cocaine, and other internationally regulated drugs (IRD). Difficulties with DSM stage-transition models have surfaced during cross-national research intended to provide a truly global perspective, such as the work of the World Mental Health Surveys (WMHS) Consortium. Alternative simpler dependence-related phenotypes are possible, including population-level count process models for steps early and before coalescence of clinical features into a coherent syndrome (e.g., zero-inflated Poisson regression). Selected findings are reviewed, based on ZIP modeling of alcohol, tobacco, and IRD count processes, with an illustration that may stimulate new research on genetic susceptibility traits. The annual National Surveys on Drug Use and Health can be readily modified for this purpose, along the lines of a truly anonymous research approach that can help make NSDUH-type cross-national epidemiological surveys more useful in the context of subsequent genome wide association (GWAS) research and post-GWAS investigations with a truly global health perspective. PMID:20201862

A meta-analysis of single case research studies on aided augmentative and alternative communication systems with individuals with autism spectrum disorders.

PubMed

Ganz, Jennifer B; Earles-Vollrath, Theresa L; Heath, Amy K; Parker, Richard I; Rispoli, Mandy J; Duran, Jaime B

2012-01-01

Many individuals with autism cannot speak or cannot speak intelligibly. A variety of aided augmentative and alternative communication (AAC) approaches have been investigated. Most of the research on these approaches has been single-case research, with small numbers of participants. The purpose of this investigation was to meta-analyze the single case research on the use of aided AAC with individuals with autism spectrum disorders (ASD). Twenty-four single-case studies were analyzed via an effect size measure, the Improvement Rate Difference (IRD). Three research questions were investigated concerning the overall impact of AAC interventions on targeted behavioral outcomes, effects of AAC interventions on individual targeted behavioral outcomes, and effects of three types of AAC interventions. Results indicated that, overall, aided AAC interventions had large effects on targeted behavioral outcomes in individuals with ASD. AAC interventions had positive effects on all of the targeted behavioral outcome; however, effects were greater for communication skills than other categories of skills. Effects of the Picture Exchange Communication System and speech-generating devices were larger than those for other picture-based systems, though picture-based systems did have small effects.

Past collapse and late Holocene reestablishment of the Petermann Ice Tongue, Northwest Greenland

NASA Astrophysics Data System (ADS)

Reilly, B. T.; Stoner, J. S.; Mix, A. C.; Jakobsson, M.; Jennings, A. E.; Walczak, M.; Dyke, L. M.

2017-12-01

Petermann Glacier, Northwest Greenland, has been a stable outlet glacier of the Greenland Ice Sheet on historical timescales. Yet, anomalous calving events in 2010 and 2012 and oceanographic studies over the last decade indicate that Petermann Glacier and its ice tongue are especially sensitive to ice-ocean interactions, leading many to speculate on its future stability. To place these observations in the context of a longer timeframe and better understand the sensitivity of Petermann Glacier to future climate change, a 2015 international and interdisciplinary expedition of the Icebreaker Oden collected a suite of sediment cores from Petermann Fjord, spanning the mid to late Holocene and forming a transect from beneath the modern ice tongue to the mouth of the fjord (25 - 80 km from the modern grounding line). We characterize the stratigraphy ( 5.5 - 6.5 m at piston core sites) using a combination of X-ray fluorescence (XRF) scanning geochemistry, computed tomography (CT) scanning, and particle-size specific magnetic measurements on these cores and nearby terrestrial samples. Age-depth modeling, based on radiocarbon dated benthic foraminifera, is in progress with reservoir age corrections assessed using paleomagnetic comparisons to regional and global records. We observe changes in the composition and spatial pattern of ice rafted debris (IRD) and sediment fabric that reveal a dynamic history. Following early Holocene deglaciation of the region, a paleo-ice tongue broke up and an extended period of seasonally open marine conditions ensued through the middle Holocene. This ice-tongue collapse was followed by a large increase in the relative abundance of Petermann sourced IRD of non-local granitic composition. This granitic IRD component steadily declined through the middle Holocene, reaching negligible contributions when the ice tongue was reestablished in the late Holocene. Regional paleoenvironmental studies suggest warmer oceanographic and atmospheric conditions around Northwest Greenland in the middle Holocene, offering an opportunity to study the sensitivity of one of Greenland's major outlet glaciers to environmental forcing.

Late Quaternary paleoenvironmental changes revealed by multi-proxy records from the Chukchi Abyssal Plain, western Arctic Ocean

NASA Astrophysics Data System (ADS)

Wang, Rujian; Xiao, Wenshen; März, Christian; Li, Qianyu

2013-09-01

Late Quaternary paleoenvironmental changes in the western Arctic Ocean are revealed by multi-proxy records of core 03M03 from the Chukchi Abyssal Plain (CAP). Proxy parameters include lithology, grain size fractions, and mineralogy and petrology of ice-rafted detritus (IRD), element contents, biogenic components, δ18O, δ13C and Mg/Ca of planktonic foraminifera Neogloboquadrina pachyderma (sin.) (Nps). Seven IRD (> 250 μm) peaks are interpreted as marking detrital input by rafting sea ice or icebergs during MIS 3 interstadials and early MIS 1. High MnO, CaO and MgO contents and high Ca/Al and Mg/Al ratios during MIS 3 and MIS 1 correspond to increases in ice-rafted detrital carbonates and the synchronous declines in siliciclastic elements (e.g., Al2O3, Fe2O3). Therefore, these warmer periods were characterized by a high detrital carbonate input entrained in icebergs from the Canadian Arctic Archipelago coeval with an increased input of Mn through rivers and/or coastal erosion. Relatively stable contents of siliciclastic elements and their ratios in the grayish sediment units are interpreted from turbid surface water plumes or nepheloid flows delivered by meltwater and/or brine rejection from ice-sheet margins at the Arctic Ocean periphery. Relatively stable clay- and silt-sized fractions were attributed mainly to sea ice entrainment over glacial-interglacial cycles. High foraminiferal abundances in the brown units during MIS 3 and 1 are related to enhanced calcareous plankton productivity under more open water conditions and/or the incremental input of Atlantic water masses. Relatively high TOC and opal contents in the grayish units of MIS 3 appear to have accumulated by lateral transport of organic matter from the Chukchi shelf to the deep abyssal plain. Lower contents of biogenic material in the brown units probably result from increased dilution by rapid IRD deposition, and from early diagenetic degradation. Depletions in Nps-δ18O and -δ13C concurrent with high foraminiferal abundances and IRD peaks within the brown units of MIS 3 and 1 are indicative of meltwater pulses, as previously documented across the Arctic Ocean. However, several Nps-δ18O and -δ13C depletions between the brown units B3 and B2 in MIS 3 could have resulted from enhanced sea ice formation. The Nps-Mg/Ca has the potential to record paleotemperature changes in the Arctic region, but still awaits a better calibration of the Nps-Mg/Ca-temperature relationship with results from core-tops, sediment traps, and plankton tows.

New thermal neutron calibration channel at LNMRI/IRD

NASA Astrophysics Data System (ADS)

Astuto, A.; Patrão, K. C. S.; Fonseca, E. S.; Pereira, W. W.; Lopes, R. T.

2016-07-01

A new standard thermal neutron flux unit was designed in the National Ionizing Radiation Metrology Laboratory (LNMRI) for calibration of neutron detectors. Fluence is achieved by moderation of four 241Am-Be sources with 0.6 TBq each, in a facility built with graphite and paraffin blocks. The study was divided into two stages. First, simulations were performed using MCNPX code in different geometric arrangements, seeking the best performance in terms of fluence and their uncertainties. Last, the system was assembled based on the results obtained on the simulations. The simulation results indicate quasi-homogeneous fluence in the central chamber and H*(10) at 50 cm from the front face with the polyethylene filter.

U.S. EPA, Pesticide Product Label, BARRAGE INDUSTRIAL STRENGTH BOWL CLEANSE, 08/20/1974

EPA Pesticide Factsheets

2011-04-14

... VIJI") "'f ';1,',111"1 nll!1) III(, h,,, p"J"'ilrl .l 1""1 l'I,lul, e,f' ','IVIC" !, t,;~, iif.',lJ.-li(' f~"~; l'_,I;J~e [._.If 1:u:..kdl.1) .trlc1 t'n·JJrl..ifHTH;lltd~ nl !Ird' ndl1<.~' V,'ln ...

Critical Zone Exploration in the Tropics: Clues from small experimental watersheds in South Cameroon and South India

NASA Astrophysics Data System (ADS)

Braun, J.-J.; Riotte, J.; Audry, S.; Boeglin, J. L.; Descloitres, M.; Deschamps, P.; Maréchal, J. C.; Viers, J.; Ndam, J.-R.; Sekhar, M.

2009-04-01

Critical Zone Exploration in the Tropics: Clues from small experimental watersheds in South Cameroon and South India J.-J. BRAUN1,2*, J. RIOTTE1,2, S. AUDRY2, J. L. BOEGLIN2, M. DESCLOITRES3, P. DESCHAMPS4, J. C. MARÉCHAL1,2, J. VIERS2, J.-R. NDAM5, M. SEKHAR6, B. DUPRÉ2 1IFCWS, Indian Institute of Science, 560012 Bangalore, India. (*Correspondence: braun@civil.iisc.ernet.in) 2LMTG, Univ. Toulouse, CNRS IRD OMP, 14, avenue E. Belin, F-31400 Toulouse, France 3LTHE, Univ. Grenoble, CNRS, IRD, INPG, BP53, F-38041 Grenoble, Cedex 09, France 4CEREGE, Univ. Aix-Marseille, CNRS, IRD, Europôle Méditerranéen de l'Arbois, BP80, 13545 Aix en Provence, France. 5Université de Yaoundé I, Faculté des Sciences, Département des Sciences de la Terre, BP80, 13545 Yaoundé, Cameroun. 6Deprtment of Civil Engineering, Indian Institute of Science, 560012 Bangalore, India Understanding the relative controls of forcing factors on the silicate chemical weathering rates and the associated atmospheric CO2 consumption is usually assessed through investigations based on small to medium granito-gneissic watersheds from 1 to100 km2 located in different climatic and tectonic settings. In addition to climate, the importance of the thickness and nature of the blanket of loose and transportable weathered material, namely regolith, which overlies the intact bedrocks, was also recently invoked, especially in tropical environment. We have conducted an integrated approach of the Critical Zone in two pristine forested small watersheds located in Cameroon and India. Both watersheds have developed on granito-gneissic bedrocks of stable Precambrian shields. Our approach is directed at (i) understanding the bio-geochemical, hydro-geological and hydrological processes and (ii) assessing the long-term and contemporary chemical weathering rates. The Nsimi watershed, South Cameroon, has been the first to be monitored since 1994. It belongs to the Nyong River basin and has a humid tropical climate. It is characterized by a deep mature lateritic mantle and mean annual rainfall of 1600 mm. The second watershed, under investigation since 2003, is located at Mule Hole, South India. It belongs to the sub-humid zone of the climatic gradient of the Kabini River basin in the rain shadow of the Western Ghâts. It is characterized by an immature thick regolith and mean annual rainfall of 1100 mm. In both watersheds, the water balance was calculated from on time-series of hydrological and climatic data and then modelled for lean/normal/high rainfall years. The contemporary chemical weathering rates were established by coupling the water balance with geochemical time-series in groundwater, stream water and rainfall. The degree of weathering and the thickness of the regolith were achieved by combining investigations of geophysics (electrical resistivity logging and tomography), mineralogy, and bulk chemical analyses. This allowed us to assess the long-term chemical weathering mass balance at the watershed scale. In the Nsimi watershed, the contemporary chemical weathering rate, even though low (2.8 mm/kyr), predominates over the mechanical weathering rate (1.9 mm/kyr). Compared to the Rio Icacos watershed, the most studied tropical site, the chemical weathering fluxes of silica and sodium in the stream are 16 and 40 times lower, respectively. This is not only related to the protective role of the regolith, thick in both cases, but also to differences in the hydrological functioning. The carbon transfer occurs primarily in an organic form and essentially as colloids produced by the slow biodegradation of the swamp organic matter. These organic colloids contribute significantly to the mobilization and transfer of Fe, Al, Zr, Ti and Th in the uppermost first meter of the swamp regolith. In the Mule Hole watershed, the contemporary mechanical weathering rate (25 mm/kyr), predominates over the chemical weathering rate estimated for both stream (0.3 mm/kyr) and groundwater (3.0 mm/kyr). This difference is due to the disconnection of groundwater and stream during the monitored period of time. The contemporary denudation rate is then 28 mm/kyr, twice the one integrated over the last 100 kyr estimated with 10Be with the streambed sand. The immature, relatively thick regolith has a great potential to produce alkalinity by chemical weathering. Depending on the runoff and therefore climate variability with a more humid gradient (i. e. intensification of the monsoon), the production of alkalinity would increase and consequently increase the atmospheric CO2 consumption. This study has important signification in terms of quantification of the amount of weathered material at small watershed scale and hence of the assessment of the impact of silicate chemical weathering on atmospheric CO2 consumption. The hydrological functioning may then constitute a critical parameter for carbon cycle modelling. This study also stresses the need to have accurate monitoring at the watershed scale in a context of changing climate and to maintain such observatories for decades. Braun, J.-J. et al. (2008) Regolith mass balance inferred from combined mineralogical, geochemical and geophysical studies: Mule Hole gneissic watershed, South India. Geochimica et Cosmochimica Acta doi: 10.1016/j.gca.2008.11.013 Braun, J. J. (2005) Present weathering rates in a humid tropical watershed: Nsimi, South Cameroon. Geochimica et Cosmochimica Acta 69, 357-387. Maréchal, J.-C. et al. (2009) Indirect and direct recharges in a tropical forested watershed: Mule Hole, India. Journal of Hydrology 364, 272-284.

A comparison of artificial turf.

PubMed

Naunheim, Rosanne; Parrott, Heather; Standeven, John

2004-12-01

In an attempt to decrease injuries, newer forms of artificial turf have been marketed. The purpose of this study was to determine whether a new shredded rubber-based turf improves impact attenuation. An instrumented computerized impact recording device (IRD, Techmark, Lansing, MI) was dropped 20 times from a height of 48 inches onto five types of turf used by a professional football team. Duncan's multiple range test shows that the new rubber-based field and the older foam field are not significantly different. There were significant differences, however, between sites on the shredded rubber-based field. The change from a foam-based system to a shredded rubber-based system had no effect on impact attenuation overall. However, areas in the shredded rubber-based field were significantly compacted, causing some sites to be much harder than the foam-based surface it replaced.

Anatomy of Heinrich Layer 1 and its role in the last deglaciation

NASA Astrophysics Data System (ADS)

Hodell, David A.; Nicholl, Joseph A.; Bontognali, Tomaso R. R.; Danino, Steffan; Dorador, Javier; Dowdeswell, Julian A.; Einsle, Joshua; Kuhlmann, Holger; Martrat, Belen; Mleneck-Vautravers, Maryline J.; Rodríguez-Tovar, Francisco Javier; Röhl, Ursula

2017-03-01

X-ray fluorescence (XRF) core scanning and X-ray computed tomography data were measured every 1 mm to study the structure of Heinrich Event 1 during the last deglaciation at International Ocean Discovery Program Site U1308. Heinrich Layer 1 comprises two distinct layers of ice-rafted detritus (IRD), which are rich in detrital carbonate (DC) and poor in foraminifera. Each DC layer consists of poorly sorted, coarse-grained clasts of IRD embedded in a dense, fine-grained matrix of glacial rock flour that is partially cemented. The radiocarbon ages of foraminifera at the base of the two layers indicate a difference of 1400 14C years, suggesting that they are two distinct events, but the calendar ages depend upon assumptions made for surface reservoir ages. The double peak indicates at least two distinct stages of discharge of the ice streams that drained the Laurentide Ice Sheet through Hudson Strait during HE1 or, alternatively, the discharge of two independent ice streams containing detrital carbonate. Heinrich Event 1.1 was the larger of the two events and began at 16.2 ka (15.5-17.1 ka) when the polar North Atlantic was already cold and Atlantic Meridional Overturning Circulation (AMOC) weakened. The younger peak (H1.2) at 15.1 ka (14.3 to 15.9 ka) was a weaker event than H1.1 that was accompanied by minor cooling. Our results support a complex history for Heinrich Stadial 1 (HS1) with reduction in AMOC during the early part ( 20-16.2 ka) possibly driven by melting of European ice sheets, whereas the Laurentide Ice Sheet assumed a greater role during the latter half ( 16.2-14.7 ka).

Size-dependent δ18O and δ13C variations in a planktic foraminiferal Neogloboquadrina pachyderma (sinistral) record from Chukchi Plateau: implications for (sub)surface water conditions in the western Arctic Ocean over the past 50 ka

NASA Astrophysics Data System (ADS)

Wang, R.; Xiao, W.; Mei, J.; Polyak, L.

2017-12-01

Oxygen and carbon stable isotopes in planktic foraminifera Neogloboquadrina pachyderma (sinistral) (Nps) have a promising potential for reconstructing (sub)surface water conditions in the Arctic Ocean. Size-dependent (63-154 µm, 154-250 µm, and >250 µm) Nps δ18O and δ13C were measured along with Ice Rafted Debris (IRD) and scanned XRF Ca and Mn contents in sediment core ARC3-P31 from the Chukchi Plateau (434 m water depth) representing paleoceanographic conditions during the last 50 ka (Marine Isotope Stages 1-3). While the interval corresponding to the Last Glacial Maximum is represented by a hiatus, the following deglaciation is clearly marked by a strong depletion in both δ18O and δ13C in all Nps size fractions along with a peak in detrital carbonate IRD indicative of the Canadian Arctic Archipelago provenance. This pronounced feature presumably indicates a collapse event of the northwestern Laurentide Ice Sheet, potentially linked to the rising sea level. In the overall record under study, average values of Nps δ18O and δ13C fluctuate in the range of 1.2-2.1‰ and 0.3-0.9 ‰, respectively. Mid-size Nps δ18O values (154-250 µm) are in average lighter by 0.2-0.5 ‰ than those of small (63-154 µm) and large (>250 µm) Nps tests. This offset may indicate a different water-depth dwelling, possibly affected by a relatively warm subsurface Atlantic water.

HIV and co-infections

PubMed Central

Chang, Christina C; Crane, Megan; Zhou, JingLing; Mina, Michael; Post, Jeffrey J; Cameron, Barbara A; Lloyd, Andrew R; Jaworowski, Anthony; French, Martyn A; Lewin, Sharon R

2013-01-01

Summary Despite significant reductions in morbidity and mortality secondary to availability of effective combination antiretroviral therapy (cART), human immunodeficiency virus (HIV) infection still accounts for 1.5 million deaths annually. The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high. In this review, we discuss the immunopathogenesis of five common infections that cause significant morbidity in HIV-infected patients globally. These include co-infection with Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. Specifically, we review the natural history of each co-infection in the setting of HIV, the specific immune defects induced by HIV, the effects of cART on the immune response to the co-infection, the pathogenesis of immune restoration disease (IRD) associated with each infection, and advances in the areas of prevention of each co-infection via vaccination. Finally, we discuss the opportunities and gaps for future research. PMID:23772618

Covering Numbers for Semicontinuous Functions

DTIC Science & Technology

2016-04-29

functions, epi-distance, Attouch-Wets topology, epi-convergence, epi-spline, approximation theory . Date: April 29, 2016 1 Introduction Covering numbers of...classes of functions play central roles in parts of information theory , statistics, and applications such as machine learning; see for example [26...probability theory because there the hypo-distance metrizes weak convergence of distribution functions on IRd, which obviously are usc [22]. Thus, as an

Data Management Standards in Computer-aided Acquisition and Logistic Support (CALS)

NASA Technical Reports Server (NTRS)

Jefferson, David K.

1990-01-01

Viewgraphs and discussion on data management standards in computer-aided acquisition and logistic support (CALS) are presented. CALS is intended to reduce cost, increase quality, and improve timeliness of weapon system acquisition and support by greatly improving the flow of technical information. The phase 2 standards, industrial environment, are discussed. The information resource dictionary system (IRDS) is described.

FASCODE - Fast Atmospheric Signature Code (Spectral Transmittance and Radiance)

DTIC Science & Technology

1978-01-16

cA6 Approvued o ulcrlae distrnibuin nimtd I? OSTIUTIN TAEMNT(. te ~FrAc1aieW iRD ADDRES 10- iiON 1diE$@NT.t haul fl TASK VIS. dn IPLM nTAR viNOT...the Voigt line shape profile model discussed above. In addition, the Voigt model provides a proper treatment of the transition region at those

Policy Capturing with Local Models: The Application of the AID technique in Modeling Judgment

DTIC Science & Technology

1972-12-01

or coding phases have upon the derived policy modelo . Particularly important aspects of these subtasks include: 1) Initial identification and coding of...in o c building pJha~sed a.ird the 1 50 a ~pli- atuls f the cr osi - vuljdatiof po[pulationl. Th.is iiicreasv iii aitr ilvatabl to Lxo ba sic fa ctu r

MCNP SIMULATION OF THE HP(10) ENERGY RESPONSE OF A BRAZILIAN TLD ALBEDO NEUTRON INDIVIDUAL DOSEMETER, FROM THERMAL TO 20 MeV.

PubMed

Freitas, B M; Martins, M M; Pereira, W W; da Silva, A X; Mauricio, C L P

2016-09-01

The Brazilian Instituto de Radioproteção e Dosimetria (IRD) runs a neutron individual monitoring system with a home-made TLD albedo dosemeter. It has already been characterised and calibrated in some reference fields. However, the complete energy response of this dosemeter is not known, and the calibration factors for all monitored workplace neutron fields are difficult to be obtained experimentally. Therefore, to overcome such difficulties, Monte Carlo simulations have been used. This paper describes the simulation of the HP(10) neutron response of the IRD TLD albedo dosemeter using the MCNPX transport code, for energies from thermal to 20 MeV. The validation of the MCNPX modelling is done comparing the simulated results with the experimental measurements for ISO standard neutron fields of (241)Am-Be, (252)Cf, (241)Am-B and (252)Cf(D2O) and also for (241)Am-Be source moderated with paraffin and silicone. Bare (252)Cf are used for normalisation. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Sedimentary record of sub-glacial outburst floods at Laurentian Fan

NASA Astrophysics Data System (ADS)

Leng, Wei; von Dobeneck, Tilo

2016-04-01

Large-scale glacial meltwater discharge could be widely recognized off the eastern Canadian continental margin. At Laurentian Fan, sub-glacial outburst floods eroded Permian-Carboniferous redbeds at Gulf of St. Lawrence and then delivered the reddish sediments by Laurentian Channel. Sedimentary record from four gravity cores (GeoB18514-2, 18515-1, 18516-2 and 18517-1) at the SW slope of the Grand Banks of Newfoundland revealed the major depositional processes since Heinrich event 2 (ca. 22 ka). In the cores, the upper thick Holocene olive-grey silty mud units overly IRD-rich Heinrich 1 layer, five reddish units are distinguished in the lower part. Reddish units get proportionally thinner along the SW slope at higher and more distal positions; instead, separating olive-grey layers get thicker with height and distance. Reddish and olive grey units have sharp boundaries and no signs of erosion. Mean grain size changes abruptly from coarse in grey layers to fine in reddish layers, terrigenous elements (as Al, K, Ti, Fe) and clays (Al/Si) are highly elevated in reddish layers and low in Heinrich layers, which are instead enriched in detrital continental carbonates. Both Heinrich layers and reddish layers have enhanced magnetic susceptibility, but Heinrich layer have higher ferromagnetic (SIRM) content (mafic rocks), while reddish layers have more hematite (HIRM). These five reddish layers differ from event to event, which seems to reflect different mixing ratios of event-related and background sedimentation. This mixing will allow estimating event-specific sedimentation rates. Using mixing ratio combined with 14C dating data could contribute to estimate the sedimentation rate and duration of outburst floods, which could help to build ice sheet retreat history and find the connection with paleoclimate changes.

How the Army Runs: A Senior Leader Reference Handbook. 2013-2014

DTIC Science & Technology

2013-01-01

sector , creates a recruiting multiplier, improves employment prospects for transitioning personnel, reduces unemployment compensation costs to the Army...Development (IR&D) efforts. By providing the private sector an unclassified, descriptive list of desired FOCs, the Army is able to tap into a wealth of...civilian sector resources during mobilization. It coordinates the response of the civil agencies to defense needs, always cognizant that without

How the Army Runs: A Senior Leader Reference Handbook, 2015-2016

DTIC Science & Technology

2015-08-28

sector , creates a recruiting multiplier, improves employment prospects for transitioning personnel, reduces unemployment compensation costs to the Army...and the private sector . (3) Consider three general time frames of near-term (associate with the future-years defense program), mid-term (10-15...TRADOC Pamphlet 525-66 also guides Independent Research & Development (IR&D) efforts. By providing the private sector an unclassified, descriptive

Roadmap evolution: from NTRS to ITRS, from ITRS 2.0 to IRDS

NASA Astrophysics Data System (ADS)

Gargini, Paolo A.

2017-10-01

The semiconductor industry benefitted from roadmap guidance since the mid-60s. The roadmap anticipated and outlined the main needs of the semiconductor industry for years to come and identified future challenges and possible solutions. Making transistor smaller by means of advanced lithographic technologies enabled both increased integration levels and improved IC performance. The roadmap methodology allowed the removal of multiple "red brick walls". The NTRS and the ITRS constituted primarily a "bottom up" approach as standard microprocessors and memories where introduced at a blistering pace barely allowing time for system houses to integrate them in their products. The 1998 ITRS provided the vision that triggered research, development and manufacturing communities to develop a completely new transistor structure in addition to replacing aluminum interconnects with a more advanced technology. The advent of Foundries and Fabless companies transformed the electronics industry into a "top down" driven industry in the past 15 years. The ITRS adjusted to this new ecosystem and morphed into the International Roadmap for Devices and Systems (IRDS) sponsored by IEEE. The IRDS is addressing the requirements and needs of the renewed electronics industry. Furthermore, by the middle of the next decade the ability to layout integrated circuits in a 2D geometry grid will reach fundamental physical limits and the aggressive conversion to 3D architecture for integrated circuit must be pursued across the board as an avenue to continuously increasing transistor count and improving performance. EUV technology is finally approaching the manufacturing stage but with the advent of 3D monolithically integrated heterogeneous circuits approaching in the not-toodistant future should the semiconductor industry concentrate its resources on the next lithographic technology generation in order to enhance resolution or on providing a smooth transition to the new revolutionary 3D architecture of integrated circuits? It is essential for the whole semiconductor industry to come together and make fundamental choices leading to a cooperative and synchronized allocation of adequate resources to produce viable solutions that once introduced in a timely manner into manufacturing will enable the continuation of the growth of the electronic industry at a pace comparable or exceeding historical trends.

Characterization of Patients Who Present With Insomnia: Is There Room for a Symptom Cluster-Based Approach?

PubMed Central

Crawford, Megan R.; Chirinos, Diana A.; Iurcotta, Toni; Edinger, Jack D.; Wyatt, James K.; Manber, Rachel; Ong, Jason C.

2017-01-01

Study Objectives: This study examined empirically derived symptom cluster profiles among patients who present with insomnia using clinical data and polysomnography. Methods: Latent profile analysis was used to identify symptom cluster profiles of 175 individuals (63% female) with insomnia disorder based on total scores on validated self-report instruments of daytime and nighttime symptoms (Insomnia Severity Index, Glasgow Sleep Effort Scale, Fatigue Severity Scale, Beliefs and Attitudes about Sleep, Epworth Sleepiness Scale, Pre-Sleep Arousal Scale), mean values from a 7-day sleep diary (sleep onset latency, wake after sleep onset, and sleep efficiency), and total sleep time derived from an in-laboratory PSG. Results: The best-fitting model had three symptom cluster profiles: “High Subjective Wakefulness” (HSW), “Mild Insomnia” (MI) and “Insomnia-Related Distress” (IRD). The HSW symptom cluster profile (26.3% of the sample) reported high wake after sleep onset, high sleep onset latency, and low sleep efficiency. Despite relatively comparable PSG-derived total sleep time, they reported greater levels of daytime sleepiness. The MI symptom cluster profile (45.1%) reported the least disturbance in the sleep diary and questionnaires and had the highest sleep efficiency. The IRD symptom cluster profile (28.6%) reported the highest mean scores on the insomnia-related distress measures (eg, sleep effort and arousal) and waking correlates (fatigue). Covariates associated with symptom cluster membership were older age for the HSW profile, greater obstructive sleep apnea severity for the MI profile, and, when adjusting for obstructive sleep apnea severity, being overweight/obese for the IRD profile. Conclusions: The heterogeneous nature of insomnia disorder is captured by this data-driven approach to identify symptom cluster profiles. The adaptation of a symptom cluster-based approach could guide tailored patient-centered management of patients presenting with insomnia, and enhance patient care. Citation: Crawford MR, Chirinos DA, Iurcotta T, Edinger JD, Wyatt JK, Manber R, Ong JC. Characterization of patients who present with insomnia: is there room for a symptom cluster-based approach? J Clin Sleep Med. 2017;13(7):911–921. PMID:28633722

Subsurface North Atlantic warming as a trigger of rapid cooling events: evidences from the Early Pleistocene (MIS 31-19)

NASA Astrophysics Data System (ADS)

Hernández-Almeida, I.; Sierro, F.-J.; Cacho, I.; Flores, J.-A.

2014-10-01

Subsurface water column dynamics in the subpolar North Atlantic were reconstructed in order to improve the understanding of the cause of abrupt IRD events during cold periods of the Early Pleistocene. We used Mg / Ca-based temperatures of deep-dwelling (Neogloboquadrina pachyderma sinistral) planktonic foraminifera and paired Mg / Ca-δ18O measurements to estimate the subsurface temperatures and δ18O of seawater at Site U1314. Carbon isotopes on benthic and planktonic foraminifera from the same site provide information about the ventilation and water column nutrient gradient. Mg / Ca-based temperatures and δ18O of seawater suggest increased temperatures and salinities during ice-rafting, likely due to enhanced northward subsurface transport of subtropical waters during periods of AMOC reduction. Planktonic carbon isotopes support this suggestion, showing coincident increased subsurface ventilation during deposition of ice-rafted detritus (IRD). Warm waters accumulated at subsurface would result in basal warming and break-up of ice-shelves, leading to massive iceberg discharges in the North Atlantic. Release of heat and salt stored at subsurface would help to restart the AMOC. This mechanism is in agreement with modelling and proxy studies that observe a subsurface warming in the North Atlantic in response to AMOC slowdown during the MIS3.

Neonatal isoflavone exposure interferes with the reproductive system of female Wistar rats.

PubMed

Müller, Dennis R; Soukup, Sebastian T; Kurrat, Anne; Liu, Xin; Schmicke, Marion; Xie, Ming-Yong; Kulling, Sabine E; Diel, Patrick

2016-11-16

There is increasing concern about possible adverse effects of soy based infant formulas (SBIF) due to their high amount of isoflavones (ISO). The aim of the present study was to investigate effects of neonatal exposure to ISO on reproductive system of female Wistar rats. Animals were exposed to an ISO depleted diet or a diet enriched with an ISO extract (IRD; 508mg ISO/kg) during embryogenesis and adolescence. Pups of each group were fed daily by pipette with ISO-suspension (ISO+; 32mg ISO/kg bw) or placebo from postnatal day (PND) 1 until PND23 resulting in plasma concentrations similar to levels reported in infants fed SBIF. The visceral fat mass was reduced by long-term IRD. Vaginal epithelial height was increased at PND23 and vaginal opening was precocious in ISO+ groups. Later in life, more often irregular estrus cycles were observed in rats of ISO+ groups. In addition, FSH levels and uterine epithelial heights were increased at PND80 in ISO+ groups. In summary, the results indicate that neonatal ISO intake, resulting in plasma concentrations achievable through SBIF, has an estrogenic effect on prepubertal rats and influences female reproductive tract later in life. Copyright © 2016. Published by Elsevier Ireland Ltd.

Estimation of internal exposure to 99Mo in nuclear medicine patients.

PubMed

Silva, I C O A; Lucena, E A; Souza, W O; Dantas, A L A; Dantas, B M

2010-05-10

(99m)Tc is the most widely used radionuclide in nuclear medicine. It is obtained by elution of (99)Mo-(99m)Tc generators. Depending on the quality of the generator and its integrity, (99)Mo may be extracted from the column during the elution process, becoming a radionuclidic impurity in the (99m)Tc eluate. This fact would impart an unnecessary dose to the patients submitted to diagnostic procedures. The aim of this work is to evaluate (99)Mo incorporation and internal effective doses in nuclear medicine patients through bioassay techniques, providing information on the metabolism of molybdenum in humans. A methodology based on in vivo and in vitro measurements was developed. In vivo measurements were performed with a NaI detector installed in the IRD WBC. Urine samples were analysed with a HPGe at the IRD bioassay laboratory. Patients showed detectable activities of (99)Mo in whole body and urine. Results were interpreted with AIDE software. Estimated incorporation was compared to predicted values based on ICRP model. Effective doses were in the order of micro sieverts. Results suggest the need to implement a routine quality control program of radionuclidic impurity of (99)Mo in (99m)Tc eluates to be conducted by radiopharmacy laboratories of nuclear medicine centers.

Calcium content and high calcium adaptation of plants in karst areas of southwestern Hunan, China

NASA Astrophysics Data System (ADS)

Wei, Xiaocong; Deng, Xiangwen; Xiang, Wenhua; Lei, Pifeng; Ouyang, Shuai; Wen, Hongfang; Chen, Liang

2018-05-01

Rocky desertification is a major ecological problem of land degradation in karst areas. In these areas, the high soil calcium (Ca) content has become an important environmental factor that can affect the restoration of vegetation. Consequently, the screening of plant species that can adapt to high Ca soil environments is a critical step in vegetation restoration. In this study, three grades of rocky desertification sample areas were selected in karst areas of southwestern Hunan, China (LRD: light rocky desertification; MRD: moderate rocky desertification; and IRD: intense rocky desertification). Each grade of these sample areas had three sample plots in different slope positions, each of which had four small quadrats (one in rocky-side areas, three in non-rocky-side areas). We measured the Ca content of leaves, branches, and roots from 41 plant species, as well as soil total Ca (TCa) and exchangeable Ca (ECa) at depths of 0-15, 15-30, and 30-45 cm in each small quadrat. The results showed that the soil Ca2+ content in rocky-side areas was significantly higher than that in non-rocky-side areas (p < 0.05). The mean soil TCa and ECa content increased gradually along with the grade of rocky desertification, in the order IRD > MRD > LRD. For all plant functional groups, the plant Ca content of aboveground parts was significantly higher than that of the belowground parts (p < 0.05). The soil ECa content had significant effects on plant Ca content of the belowground parts but had no significant effects on plant Ca content of the aboveground parts. Of the 41 plant species that were sampled, 17 were found to be dominant (important value > 1). The differences in Ca2+ content between the aboveground and belowground parts of the 17 dominant species were calculated, and their correlations with soil ECa content were analyzed. The results showed that these 17 species can be divided into three categories: Ca-indifferent plants, high-Ca plants, and low-Ca plants. These findings provide a vital theoretical basis and practical guide for vegetation restoration and ecosystem reconstruction in rocky desertification areas.

Advanced Packaging for VLSI/VHSIC (Very Large Scale Integrated Circuits/Very High Speed Integrated Circuits) Applications: Electrical, Thermal, and Mechanical Considerations - An IR&D Report.

DTIC Science & Technology

1987-11-01

developed that can be used by circuit engineers to extract the maximum performance from the devices on various board technologies including multilayer ceramic...Design guidelines have been developed that can be used by circuit engineers to extract the maxi- mum performance from the devices on various board...25 Attenuation and Dispersion Effects ......................................... 27 Skin Effect

Results of SEI Independent Research and Development Projects and Report on Emerging Technologies and Technology Trends

DTIC Science & Technology

2005-12-01

W. Collins Peter Feiler John Goodenough Aaron Greenhouse Jorgen Hansson Alan R . Hevner John Hudak Angel Jordan Rick Kazman Richard C. Linger...John Goodenough Aaron Greenhouse Jorgen Hansson Alan R . Hevner John Hudak Angel Jordan Rick Kazman Richard C. Linger Mark G. Pleszkoch Stacy J...operability, sustainability, software R &D, metrics for acquisition, acquisition management, and commercial off-the-shelf products. The IR&D projects conducted

Toroidal Tank Development for Upper-stages

NASA Technical Reports Server (NTRS)

DeLay, Tom; Roberts, Keith

2003-01-01

The advantages, development, and fabrication of toroidal propellant tanks are profiled in this viewgraph presentation. Several images are included of independent research and development (IR&D) of toroidal propellant tanks at Marshall Space Flight Center (MSFC). Other images in the presentation give a brief overview of Thiokol conformal tank technology development. The presentation describes Thiokol's approach to continuous composite toroidal tank fabrication in detail. Images are shown of continuous and segmented toroidal tanks fabricated by Thiokol.

High-resolution record of the deglaciation of the British-Irish Ice Sheet from North Atlantic deep-sea sediments.

NASA Astrophysics Data System (ADS)

Tarlati, S.; Benetti, S.; Callard, L.; O'Cofaigh, C.; Dunlop, P.; Chiverrell, R. C.; Fabel, D.; Moreton, S.; Clark, C.

2016-12-01

During the last glacial maximum the British-Irish Ice Sheet (BIIS) covered the majority of Ireland and Britain. Recent studies have described the BIIS as largely marine-based and highly dynamic with several advances and retreats recorded on the continental shelf. The focus of this study is the more recent sediment record from the Donegal Barra Fan (DBF), the largest sediment depocentre formed by the ice streaming of the western BIIS onto the North Atlantic continental margin. In this project, well-preserved, glacially-derived, deep-water sediments from 3 cores, up to 6.7 m long and retrieved from the DBF, are used to investigate and chronologically constrain the pattern of deglaciation of the BIIS. Deep-water sediments can record continuous sedimentation through time, avoiding hiatuses and erosional surfaces characteristic of a glacial environment and allow a detailed reconstruction of deglacial processes. Five lithofacies have been identified using sedimentology, x-rays, physical properties and grain size analysis. They include bioturbated foraminifera-bearing muds, interpreted as hemipelagic and contouritic deposits from interglacial periods. Chaotic and laminated muds, ice-rafted debris (IRD)-rich layers and laminated mud to sand couplets are characteristic of the glacial period including ice-sheet maximum extent and the beginning of retreat. These represent downslope mass movements, plumites from meltwater alongside melting icebergs and turbidites. Radiocarbon dates from foraminifera suggest that the deglacial sedimentary sequence is up to 5m thick. The IRD concentration and abundance of the foraminifera Neogloboquadrina pachyderma sinistral indicate a minimum of 3 different calving events during deglaciation and a marked Younger Dryas cooling and ice calving period. Additionally the δ 18O record will be used to investigate the record of climatic changes in the region and x-ray fluorescence will be used to assess sediment provenance during deglaciation.

Bibliographic Index of Soviet Military Books, 1970-1974.

DTIC Science & Technology

1984-01-31

Countries. These include the nations of Eastern Europe and other socialist states such as Cuba, Mongolia and Vietnam. Despite the rift between the Soviet...Everyday Life of the Belo- russian Red Banner.(Belorusskiy Voyennyy Okrug. Budni Belorusskogo Kra - noznamennogo)2nd ed. Polit Admin Red Banner Belorussian...C(,W,Nauka,1970. 773p. 30,000 3r.70k. 70-05598 ,078.’ Liberation of Southeast and Central Europe by Troops of the -.ii and ird Ukrainian Fronts

Department of Defense Chemical and Biological Defense Program. Volume I: Annual Report to Congress

DTIC Science & Technology

2002-04-01

The M21 RSCAAL is an automatic scanning, passive infrared sensor that detects nerve ( GA , GB, and GD) and blister (H and L) agent vapor clouds based on...Point Detection GA - tabun, a nerve agent System GAO - General Accounting Office IPE - Individual Protective Equipment GAS - Group A Streptococcus...IPR - In-Process Review GB - sarin , a nerve agent IPT - Integrated Product Team GC - gas chromatography IR&D - Independent Research & Development GD

Subsurface North Atlantic warming as a trigger of rapid cooling events: evidence from the early Pleistocene (MIS 31-19)

NASA Astrophysics Data System (ADS)

Hernández-Almeida, I.; Sierro, F.-J.; Cacho, I.; Flores, J.-A.

2015-04-01

Subsurface water column dynamics in the subpolar North Atlantic were reconstructed in order to improve the understanding of the cause of abrupt ice-rafted detritus (IRD) events during cold periods of the early Pleistocene. We used paired Mg / Ca and δ18O measurements of Neogloboquadrina pachyderma (sinistral - sin.), deep-dwelling planktonic foraminifera, to estimate the subsurface temperatures and seawater δ18O from a sediment core from Gardar Drift, in the subpolar North Atlantic. Carbon isotopes of benthic and planktonic foraminifera from the same site provide information about the ventilation and water column nutrient gradient. Mg / Ca-based temperatures and seawater δ18O suggest increased subsurface temperatures and salinities during ice-rafting, likely due to northward subsurface transport of subtropical waters during periods of weaker Atlantic Meridional Overturning Circulation (AMOC). Planktonic carbon isotopes support this suggestion, showing coincident increased subsurface ventilation during deposition of IRD. Subsurface accumulation of warm waters would have resulted in basal warming and break-up of ice-shelves, leading to massive iceberg discharges in the North Atlantic. The release of heat stored at the subsurface to the atmosphere would have helped to restart the AMOC. This mechanism is in agreement with modelling and proxy studies that observe a subsurface warming in the North Atlantic in response to AMOC slowdown during Marine Isotope Stage (MIS) 3.

An Internet Protocol-Based Software System for Real-Time, Closed-Loop, Multi-Spacecraft Mission Simulation Applications

NASA Technical Reports Server (NTRS)

Davis, George; Cary, Everett; Higinbotham, John; Burns, Richard; Hogie, Keith; Hallahan, Francis

2003-01-01

The paper will provide an overview of the web-based distributed simulation software system developed for end-to-end, multi-spacecraft mission design, analysis, and test at the NASA Goddard Space Flight Center (GSFC). This software system was developed for an internal research and development (IR&D) activity at GSFC called the Distributed Space Systems (DSS) Distributed Synthesis Environment (DSE). The long-term goal of the DSS-DSE is to integrate existing GSFC stand-alone test beds, models, and simulation systems to create a "hands on", end-to-end simulation environment for mission design, trade studies and simulations. The short-term goal of the DSE was therefore to develop the system architecture, and then to prototype the core software simulation capability based on a distributed computing approach, with demonstrations of some key capabilities by the end of Fiscal Year 2002 (FY02). To achieve the DSS-DSE IR&D objective, the team adopted a reference model and mission upon which FY02 capabilities were developed. The software was prototyped according to the reference model, and demonstrations were conducted for the reference mission to validate interfaces, concepts, etc. The reference model, illustrated in Fig. 1, included both space and ground elements, with functional capabilities such as spacecraft dynamics and control, science data collection, space-to-space and space-to-ground communications, mission operations, science operations, and data processing, archival and distribution addressed.

A Distributed Simulation Software System for Multi-Spacecraft Missions

NASA Technical Reports Server (NTRS)

Burns, Richard; Davis, George; Cary, Everett

2003-01-01

The paper will provide an overview of the web-based distributed simulation software system developed for end-to-end, multi-spacecraft mission design, analysis, and test at the NASA Goddard Space Flight Center (GSFC). This software system was developed for an internal research and development (IR&D) activity at GSFC called the Distributed Space Systems (DSS) Distributed Synthesis Environment (DSE). The long-term goal of the DSS-DSE is to integrate existing GSFC stand-alone test beds, models, and simulation systems to create a "hands on", end-to-end simulation environment for mission design, trade studies and simulations. The short-term goal of the DSE was therefore to develop the system architecture, and then to prototype the core software simulation capability based on a distributed computing approach, with demonstrations of some key capabilities by the end of Fiscal Year 2002 (FY02). To achieve the DSS-DSE IR&D objective, the team adopted a reference model and mission upon which FY02 capabilities were developed. The software was prototyped according to the reference model, and demonstrations were conducted for the reference mission to validate interfaces, concepts, etc. The reference model, illustrated in Fig. 1, included both space and ground elements, with functional capabilities such as spacecraft dynamics and control, science data collection, space-to-space and space-to-ground communications, mission operations, science operations, and data processing, archival and distribution addressed.

Program Manager: The Journal of the Defense Systems Management College. Volume 12, Number 3, May-June 1983.

DTIC Science & Technology

1983-01-01

reason, I believe our ability IR&D that industry invests for the mili- to fight in combat, and win, must be tary market is directed toward per- the...from this direction land examine the potential benefits, quel ha et tegartnm tcall excudedcommercial markets , the government that] particular attention...require, because normal market pres- tion of the learning curve resulting of the competing systems. It has fre- sure would force the contractors to

Validation and Application of Pharmacokinetic Models for Interspecies Extrapolations in Toxicity Risk Assessments of Volatile Organics

DTIC Science & Technology

1991-07-23

8217 I ,R . -, Thir cnc-:-. a-:. On *: - ’y -e ir~d is Dle-: £ .. _... . . STINFO P No ’ &Cz" Final Report for Period I July 1987 - 30 April 1991...OF RESEARCH PAPERS AND ABSTRACTS Appendix K I. OVERALL OBJECTIVE AND STATEMENT OF WORK The overall objective of the proposed project is to investigate...determine what adjustments in administered dose are necessary to achieve equal brain levels of test compounds in each species. An inhalation and oral

The Defense Department’s Support of Industry’s Independent Research and Development (IR&D). Analyses and Evaluation

DTIC Science & Technology

1989-04-01

Hill and Susan Bodilly were incorporated into this report. Todd Porter, a RAND Summer Intern, contributed to the data development, statistical...5Bailey and Lawrence , 1987, pp. 19-20. The R&D tax credit allowed a 25 percent credit for R&D expenditures in excess of the average amount spent...See J. A. Hausman , ’Specificaticn Tests in Econometrics,"Econormetrica, Vol, 46, No. 6, November 1978. 61 (7) and (8) report the results of this

Estimates of Surface Drifter Trajectories in the Equatorial Atlantic: A Multi-model Ensemble Approach

DTIC Science & Technology

2012-01-01

Physique des Oceans UMR6523 (CNRS. I B(). IFREMER. IRD). Brest , France C. N. Barron E. Joseph Metzger Naval Research Laboratory, Stennis Space...AF447 flight from Rio to Paris . The airplane disappeared on June 1st 2009 near 3° N and 31° W, and a large international effort was organized to...to Runge-Kutta trajectory integration. The low- pass filter was accomplished by convolving the original (XiCM velocity fields at each time step and

PI3K/Akt-dependent functions of TFII-I transcription factors in mouse embryonic stem cells.

PubMed

Chimge, Nyam-Osor; Makeyev, Aleksandr V; Waigel, Sabine J; Enkhmandakh, Badam; Bayarsaihan, Dashzeveg

2012-04-01

Activation of PI3K/Akt signaling is sufficient to maintain the pluripotency of mouse embryonic stem cells (mESC) and results in down-regulation of Gtf2i and Gtf2ird1 encoding TFII-I family transcription factors. To investigate how these genes might be involved in the process of embryonic stem cell differentiation, we performed expression microarray profiling of mESC upon inhibition of PI3K by LY294002. This analysis revealed significant alterations in expression of genes for specific subsets of chromatin-modifying enzymes. Surprisingly, genome-wide promoter ChIP-chip mapping indicated that the majority of differently expressed genes could be direct targets of TFII-I regulation. The data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation. © 2011 Wiley Periodicals, Inc.

Analysis of EDP performance

NASA Technical Reports Server (NTRS)

1994-01-01

The objective of this contract was the investigation of the potential performance gains that would result from an upgrade of the Space Station Freedom (SSF) Data Management System (DMS) Embedded Data Processor (EDP) '386' design with the Intel Pentium (registered trade-mark of Intel Corp.) '586' microprocessor. The Pentium ('586') is the latest member of the industry standard Intel X86 family of CISC (Complex Instruction Set Computer) microprocessors. This contract was scheduled to run in parallel with an internal IBM Federal Systems Company (FSC) Internal Research and Development (IR&D) task that had the goal to generate a baseline flight design for an upgraded EDP using the Pentium. This final report summarizes the activities performed in support of Contract NAS2-13758. Our plan was to baseline performance analyses and measurements on the latest state-of-the-art commercially available Pentium processor, representative of the proposed space station design, and then phase to an IBM capital funded breadboard version of the flight design (if available from IR&D and Space Station work) for additional evaluation of results. Unfortunately, the phase-over to the flight design breadboard did not take place, since the IBM Data Management System (DMS) for the Space Station Freedom was terminated by NASA before the referenced capital funded EDP breadboard could be completed. The baseline performance analyses and measurements, however, were successfully completed, as planned, on the commercial Pentium hardware. The results of those analyses, evaluations, and measurements are presented in this final report.

Flight evaluation of advanced third-generation midwave infrared sensor

NASA Astrophysics Data System (ADS)

Shen, Chyau N.; Donn, Matthew

1998-08-01

In FY-97 the Counter Drug Optical Upgrade (CDOU) demonstration program was initiated by the Program Executive Office for Counter Drug to increase the detection and classification ranges of P-3 counter drug aircraft by using advanced staring infrared sensors. The demonstration hardware is a `pin-for-pin' replacement of the AAS-36 Infrared Detection Set (IRDS) located under the nose radome of a P-3 aircraft. The hardware consists of a 3rd generation mid-wave infrared (MWIR) sensor integrated into a three axis-stabilized turret. The sensor, when installed on the P- 3, has a hemispheric field of regard and analysis has shown it will be capable of detecting and classifying Suspected Drug Trafficking Aircraft and Vessels at ranges several factors over the current IRDS. This paper will discuss the CDOU system and it's lab, ground, and flight evaluation results. Test targets included target templates, range targets, dedicated target boats, and targets of opportunity at the Naval Air Warfare Center Aircraft Division and at operational test sites. The objectives of these tests were to: (1) Validate the integration concept of the CDOU package into the P-3 aircraft. (2) Validate the end-to-end functionality of the system, including sensor/turret controls and recording of imagery during flight. (3) Evaluate the system sensitivity and resolution on a set of verified resolution targets templates. (4) Validate the ability of the 3rd generation MWIR sensor to detect and classify targets at a significantly increased range.

New and emerging technologies for the treatment of inherited retinal diseases: a horizon scanning review.

PubMed

Smith, J; Ward, D; Michaelides, M; Moore, A T; Simpson, S

2015-09-01

The horizon scanning review aimed to identify new and emerging technologies in development that have the potential to slow or stop disease progression and/or reverse sight loss in people with inherited retinal diseases (IRDs). Potential treatments were identified using recognized horizon scanning methods. These included a combination of online searches using predetermined search terms, suggestions from clinical experts and patient and carer focus groups, and contact with commercial developers. Twenty-nine relevant technologies were identified. These included 9 gene therapeutic approaches, 10 medical devices, 5 pharmacological agents, and 5 regenerative and cell therapies. A further 11 technologies were identified in very early phases of development (typically phase I or pre-clinical) and were included in the final report to give a complete picture of developments 'on the horizon'. Clinical experts and patient and carer focus groups provided helpful information and insights, such as the availability of specialised services for patients, the potential impacts of individual technologies on people with IRDs and their families, and helped to identify additional relevant technologies. This engagement ensured that important areas of innovation were not missed. Most of the health technologies identified are still at an early stage of development and it is difficult to estimate when treatments might be available. Further, well designed trials that generate data on efficacy, applicability, acceptability, and costs of the technologies, as well as the long-term impacts for various conditions are required before these can be considered for adoption into routine clinical practice.

An atypical deletion of the Williams–Beuren syndrome interval implicates genes associated with defective visuospatial processing and autism

PubMed Central

Edelmann, Lisa; Prosnitz, Aaron; Pardo, Sherly; Bhatt, Jahnavi; Cohen, Ninette; Lauriat, Tara; Ouchanov, Leonid; González, Patricia J; Manghi, Elina R; Bondy, Pamela; Esquivel, Marcela; Monge, Silvia; Delgado, Marietha F; Splendore, Alessandra; Francke, Uta; Burton, Barbara K; McInnes, L Alison

2007-01-01

Background During a genetic study of autism, a female child who met diagnostic criteria for autism spectrum disorder, but also exhibited the cognitive–behavioural profile (CBP) associated with Williams–Beuren syndrome (WBS) was examined. The WBS CBP includes impaired visuospatial ability, an overly friendly personality, excessive non‐social anxiety and language delay. Methods Using array‐based comparative genomic hybridisation (aCGH), a deletion corresponding to BAC RP11‐89A20 in the distal end of the WBS deletion interval was detected. Hemizygosity was confirmed using fluorescence in situ hybridisation and fine mapping was performed by measuring the copy number of genomic DNA using quantitative polymerase chain reaction. Results The proximal breakpoint was mapped to intron 1 of GTF2IRD1 and the distal breakpoint lies 2.4–3.1 Mb towards the telomere. The subject was completely hemizygous for GTF2I, commonly deleted in carriers of the classic ∼1.5 Mb WBS deletion, and GTF2IRD2, deleted in carriers of the rare ∼1.84 Mb WBS deletion. Conclusion Hemizygosity of the GTF2 family of transcription factors is sufficient to produce many aspects of the WBS CBP, and particularly implicate the GTF2 transcription factors in the visuospatial construction deficit. Symptoms of autism in this case may be due to deletion of additional genes outside the typical WBS interval or remote effects on gene expression at other loci. PMID:16971481

Cordilleran Ice Sheet meltwater delivery to the coastal waters of the northeast Pacific Ocean

NASA Astrophysics Data System (ADS)

Hendy, I. L.; Taylor, M.; Gombiner, J. H.; Hemming, S. R.; Bryce, J. G.; Blichert-Toft, J.

2014-12-01

Cordilleran Ice Sheet (CIS) delivered meltwater to the NE Pacific Ocean off BC and WA via glacial lake outburst floods (GLOFs), ice rafting and subglacial meltwater discharge. A deglacial glaciomarine sedimentation record is preserved in the well dated ~50-kyr core MD02-2496 (48˚58.47' N, 127˚02.14' W, water depth 1243 m), collected off Vancouver Island. To understand the history of the relationship between the CIS, climate and meltwater discharge, high resolution, multi-proxy geochemical records from the interval that captures the Fraser Glaciation (~30-10 ka) were generated. These proxies include Mg/Ca temperatures and δ18Oseawater from planktonic foraminiferal sp. N. pachyderma and G. bulloides, elemental and organic carbon (Corg) geochemistry of bulk sediments, ɛNd and K/Ar dating of the <63µm fraction. A detailed reconstruction of CIS retreat has been generated based on the source of glaciomarine sediments and ice rafted debris (IRD), as well as evidence for processes such as GLOF events and iceberg discharge. At the Fraser Glaciation initiation (~30 ka) <63µm glaciomarine sediments deposited at MD02-2496 had a ~100 Ma volcanic rock source. The CIS passed over the Vancouver Island continental shelf at Tofino at ~20 ka ~75 km from the site dramatically increasing sedimentation. From ~19 to 17.3 ka GLOFs created cyclic (~80 year) sedimentary packages of ~300 Ma (ɛNd of ~-8) shale associated with terrestrial Corg, and ~100 Ma (ɛNd of ~-3) volcanic sediment associated with marine Corg. The GLOFs were likely to be associated with glacial lake Missoula outburst flooding, occurring during the interval of the coolest ocean temperatures (2-4°C) and most depleted δ18Oseawater (-1.75‰). At 17.3 ka as ocean temperatures increased by ~3°C and δ18Oseawater increased to ~0‰, IRD deposition increased dramatically at the site, terminating abruptly at 16.2 ka. At the Bølling, ocean temperatures rose by > 3°C to 10-12°C in association with an additional IRD event at ~14.8 ka sourced from a ~75 Ma felsic volcanic source, likely the Southern Coast Plutonic Complex. At no point in the δ18Oseawater reconstruction is an obvious meltwater isotopic signature recorded despite the sedimentary evidence for both ice rafting and outburst flooding. Thus CIS meltwater likely entered the NE Pacific Ocean via hyperpycnal flow.

The effect of texture on the crack growth resistance of alumina

NASA Technical Reports Server (NTRS)

Salem, Jonathan A.; Shannon, John L., Jr.; Bradt, Richard C.

1987-01-01

The crack growth resistance of a textured, extruded alumina body was compared with that of an isotropic, isopressed body of similar grain size, density, and chemistry. R-curve levels reflected the preferred orientation; however, R-curve slopes (dK sub IR/d Delta a) were the same in all instances, implying a similar crack growth resistive mechanism. Three orthogonal orientations of crack growth in the two structures exhibited similar forms of K sub IR versus Delta-a curves, for which a schematic diagram for polycrystalline ceramics is proposed.

Determination of uncertainties associated to the in vivo measurement of iodine-131 in the thyroid.

PubMed

Dantas, B M; Lima, F F; Dantas, A L; Lucena, E A; Gontijo, R M G; Carvalho, C B; Hazin, C

2016-07-01

Intakes of radionuclides can be estimated through in vivo measurements, and the uncertainties associated to the measured activities should be clearly stated in monitoring program reports. This study aims to evaluate the uncertainties of in vivo monitoring of iodine 131 in the thyroid. The reference values for high-energy photons are based on the IDEAS Guide. Measurements were performed at the In Vivo Monitoring Laboratory of the Institute of Radiation Protection and Dosimetry (IRD) and at the Internal Dosimetry Laboratory of the Regional Center of Nuclear Sciences (CRCN-NE). In both institutions, the experiment was performed using a NaI(Tl) 3''3″ scintillation detector and a neck-thyroid phantom. Scattering factors were calculated and compared in different counting geometries. The results show that the technique produces reproducibility equivalent to the values suggested in the IDEAS Guide and measurement uncertainties is comparable to international quality standards for this type of in vivo monitoring. Copyright © 2016 Elsevier Ltd. All rights reserved.

Modeling Planet-Building Stellar Disks with Radiative Transfer Code

NASA Astrophysics Data System (ADS)

Swearingen, Jeremy R.; Sitko, Michael L.; Whitney, Barbara; Grady, Carol A.; Wagner, Kevin Robert; Champney, Elizabeth H.; Johnson, Alexa N.; Warren, Chelsea C.; Russell, Ray W.; Hammel, Heidi B.; Lisse, Casey M.; Cure, Michel; Kraus, Stefan; Fukagawa, Misato; Calvet, Nuria; Espaillat, Catherine; Monnier, John D.; Millan-Gabet, Rafael; Wilner, David J.

2015-01-01

Understanding the nature of the many planetary systems found outside of our own solar system cannot be completed without knowledge of the beginnings these systems. By detecting planets in very young systems and modeling the disks of material around stars from which they form, we can gain a better understanding of planetary origin and evolution. The efforts presented here have been in modeling two pre-transitional disk systems using a radiative transfer code. With the first of these systems, V1247 Ori, a model that fits the spectral energy distribution (SED) well and whose parameters are consistent with existing interferometry data (Kraus et al 2013) has been achieved. The second of these two systems, SAO 206462, has presented a different set of challenges but encouraging SED agreement between the model and known data gives hope that the model can produce images that can be used in future interferometry work. This work was supported by NASA ADAP grant NNX09AC73G, and the IR&D program at The Aerospace Corporation.

Thermal neutron calibration channel at LNMRI/IRD.

PubMed

Astuto, A; Salgado, A P; Leite, S P; Patrão, K C S; Fonseca, E S; Pereira, W W; Lopes, R T

2014-10-01

The Brazilian Metrology Laboratory of Ionizing Radiations (LNMRI) standard thermal neutron flux facility was designed to provide uniform neutron fluence for calibration of small neutron detectors and individual dosemeters. This fluence is obtained by neutron moderation from four (241)Am-Be sources, each with 596 GBq, in a facility built with blocks of graphite/paraffin compound and high-purity carbon graphite. This study was carried out in two steps. In the first step, simulations using the MCNPX code on different geometric arrangements of moderator materials and neutron sources were performed. The quality of the resulting neutron fluence in terms of spectrum, cadmium ratio and gamma-neutron ratio was evaluated. In the second step, the system was assembled based on the results obtained on the simulations, and new measurements are being made. These measurements will validate the system, and other intercomparisons will ensure traceability to the International System of Units. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Organic Contamination Baseline Study: In NASA JSC Astromaterials Curation Laboratories. Summary Report

NASA Technical Reports Server (NTRS)

Calaway, Michael J.

2013-01-01

In preparation for OSIRIS-REx and other future sample return missions concerned with analyzing organics, we conducted an Organic Contamination Baseline Study for JSC Curation Labsoratories in FY12. For FY12 testing, organic baseline study focused only on molecular organic contamination in JSC curation gloveboxes: presumably future collections (i.e. Lunar, Mars, asteroid missions) would use isolation containment systems over only cleanrooms for primary sample storage. This decision was made due to limit historical data on curation gloveboxes, limited IR&D funds and Genesis routinely monitors organics in their ISO class 4 cleanrooms.

Robust rotation of rotor in a thermally driven nanomotor

PubMed Central

Cai, Kun; Yu, Jingzhou; Shi, Jiao; Qin, Qing-Hua

2017-01-01

In the fabrication of a thermally driven rotary nanomotor with the dimension of a few nanometers, fabrication and control precision may have great influence on rotor’s stability of rotational frequency (SRF). To investigate effects of uncertainty of some major factors including temperature, tube length, axial distance between tubes, diameter of tubes and the inward radial deviation (IRD) of atoms in stators on the frequency’s stability, theoretical analysis integrating with numerical experiments are carried out. From the results obtained via molecular dynamics simulation, some key points are illustrated for future fabrication of the thermal driven rotary nanomotor. PMID:28393898

Prime Contract Awards by Service Category and Federal Supply Classification: Fiscal Year 1991, 1990, 1989 and 1988

DTIC Science & Technology

1992-01-01

and Sporting Equipment 3,873 3,573 1,049 1,335 7820 Games, Toys and Wheeled Goods 491 373 147 324 7830 Recreational and Gymnastic Equipment 6,811...Related Product 6,586 6,130 7,677 4,677 8020 Paint and Artists ’ Brushes 963 0 43 29 Prepared By: Washington Headquaters Services 48 Ltectorate For...334 157 0 0 0 0 7830 Recreational and Gymnastic E-,jipment 69.811 1.828 2.675 2.275 0 33 0 7910 Floor Polishers ir-d Vacuum Cleaners 2.514 1.199 579

Late Quaternary sediment deposition of core MA01 in the Mendeleev Ridge, the western Arctic Ocean: Preliminary results

NASA Astrophysics Data System (ADS)

Park, Kwang-Kyu; Kim, Sunghan; Khim, Boo-Keun; Xiao, Wenshen; Wang, Rujian

2014-05-01

Late Quaternary deep marine sediments in the Arctic Ocean are characterized by brown layers intercalated with yellowish to olive gray layers (Poore et al., 1999; Polyak et al., 2004). Previous studies reported that the brown and gray layers were deposited during interglacial (or interstadial) and glacial (or stadial) periods, respectively. A 5.5-m long gravity core MA01 was obtained from the Mendeleev Ridge in the western Arctic Ocean by R/V Xue Long during scientific cruise CHINARE-V. Age (~450 ka) of core MA01 was tentatively estimated by correlation of brown layers with an adjacent core HLY0503-8JPC (Adler et al., 2009). A total of 22 brown layers characterized by low L* and b*, high Mn concentration, and abundant foraminifera were identified. Corresponding gray layers are characterized by high L* and b*, low Mn concentration, and few foraminiferal tests. Foraminifera abundance peaks are not well correlated to CaCO3 peaks which occurred with the coarse-grained (>0.063 mm) fractions (i.e., IRD) both in brown and gray layers. IRDs are transported presumably by sea ice for the deposition of brown layers and by iceberg for the deposition of gray layers (Polyak et al., 2004). A strong correlation coefficient (r2=0.89) between TOC content and C/N ratio indicates that the major source of organic matter is terrestrial. The good correlations of CaCO3 content to TOC (r2=0.56) and C/N ratio (r2=0.69) imply that IRDs contain detrital CaCO3 which mainly originated from the Canadian Arctic Archipelago. In addition, high kaolinite/chlorite (K/C) ratios mostly correspond to CaCO3 peaks, which suggests that the fine-grained particles in the Mendeleev Ridge are transported from the north coast Alaska and Canada where Mesozoic and Cenozoic strata are widely distributed. Thus, the Beaufort Gyre, the predominant surface current in the western Arctic Ocean, played an important role in the sediment delivery to the Mendeleev Ridge. It is worthy of note that the TOC and CaCO3 peaks are obviously distinct in the upper part of core MA01, whereas these peaks are reduced in the lower part of the core. More study on these contrasting features is in progress. References Adler, R.E., Polyak, L., Ortiz, J.D., Kaufman, D.S., Channell, J.E.T., Xuan, C., Grottoli, A.G., Sellén, E., and Crawford, K.A., 2009. Global and Planetary Change 68(1-2), 18-29. Polyak, L., Curry, W.B., Darby, D.A., Bischof, J., and Cronin, T.M., 2004. Palaeogeography, Palaeoclimatology, Palaeoecology 203, 73-93. Poore, R., Osterman, L., Curry, W., and Phillips, R., 1999. Geology 27, 759-762.

Lunar base thermal management/power system analysis and design

NASA Technical Reports Server (NTRS)

Mcghee, Jerry R.

1992-01-01

A compilation of several lunar surface thermal management and power system studies completed under contract and IR&D is presented. The work includes analysis and preliminary design of all major components of an integrated thermal management system, including loads determination, active internal acquisition and transport equipment, external transport systems (active and passive), passive insulation, solar shielding, and a range of lunar surface radiator concepts. Several computer codes were utilized in support of this study, including RADSIM to calculate radiation exchange factors and view factors, RADIATOR (developed in-house) for heat rejection system sizing and performance analysis over a lunar day, SURPWER for power system sizing, and CRYSTORE for cryogenic system performance predictions. Although much of the work was performed in support of lunar rover studies, any or all of the results can be applied to a range of surface applications. Output data include thermal loads summaries, subsystem performance data, mass, and volume estimates (where applicable), integrated and worst-case lunar day radiator size/mass and effective sink temperatures for several concepts (shielded and unshielded), and external transport system performance estimates for both single and two-phase (heat pumped) transport loops. Several advanced radiator concepts are presented, along with brief assessments of possible system benefits and potential drawbacks. System point designs are presented for several cases, executed in support of the contract and IR&D studies, although the parametric nature of the analysis is stressed to illustrate applicability of the analysis procedure to a wide variety of lunar surface systems. The reference configuration(s) derived from the various studies will be presented along with supporting criteria. A preliminary design will also be presented for the reference basing scenario, including qualitative data regarding TPS concerns and issues.

A mobile bioassay laboratory for the assessment of internal doses based on in vivo and in vitro measurements.

PubMed

Dantas, B M; Lucena, E A; Dantas, A L A; Santos, M S; Julião, L Q C; Melo, D R; Sousa, W O; Fernandes, P C; Mesquita, S A

2010-10-01

Internal exposures may occur in nuclear power plants, radioisotope production, and in medicine and research laboratories. Such practices require quick response in case of accidents of a wide range of magnitudes. This work presents the design and calibration of a mobile laboratory for the assessment of accidents involving workers and the population as well as for routine monitoring. The system was set up in a truck with internal dimensions of 3.30 m × 1.60 m × 1.70 m and can identify photon emitters in the energy range of 100-3,000 keV in the whole body, organs, and in urine. A thyroid monitor consisting of a lead-collimated NaI(Tl)3" × 3" (7.62 × 7.62 cm) detector was calibrated with a neck-thyroid phantom developed at the IRD (Instituto de Radioproteção e Dosimetria). Whole body measurements were performed with a NaI(Tl)8" × 4" (20.32 × 10.16 cm) detector calibrated with a plastic-bottle phantom. Urine samples were measured with another NaI(Tl) 3" × 3" (7.62 × 7.62 cm) detector set up in a steel support. Standard solutions were provided by the National Laboratory for Metrology of Ionizing Radiation of the IRD. Urine measurements are based on a calibration of efficiency vs. energy for standard volumes. Detection limits were converted to minimum committed effective doses for the radionuclides of interest using standard biokinetic and dosimetric models in order to evaluate the applicability and limitations of the system. Sensitivities for high-energy activation and fission products show that the system is suitable for use in emergency and routine monitoring of individuals under risk of internal exposure by such radionuclides.

The contribution of CLIP2 haploinsufficiency to the clinical manifestations of the Williams-Beuren syndrome.

PubMed

Vandeweyer, Geert; Van der Aa, Nathalie; Reyniers, Edwin; Kooy, R Frank

2012-06-08

Williams-Beuren syndrome is a rare contiguous gene syndrome, characterized by intellectual disability, facial dysmorphisms, connective-tissue abnormalities, cardiac defects, structural brain abnormalities, and transient infantile hypercalcemia. Genes lying telomeric to RFC2, including CLIP2, GTF2I and GTF2IRD1, are currently thought to be the most likely major contributors to the typical Williams syndrome cognitive profile, characterized by a better-than-expected auditory rote-memory ability, a relative sparing of language capabilities, and a severe visual-spatial constructive impairment. Atypical deletions in the region have helped to establish genotype-phenotype correlations. So far, however, hardly any deletions affecting only a single gene in the disease region have been described. We present here two healthy siblings with a pure, hemizygous deletion of CLIP2. A putative role in the cognitive and behavioral abnormalities seen in Williams-Beuren patients has been suggested for this gene on the basis of observations in a knock-out mouse model. The presented siblings did not show any of the clinical features associated with the syndrome. Cognitive testing showed an average IQ for both and no indication of the Williams syndrome cognitive profile. This shows that CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome, nor does it lead to the Williams syndrome cognitive profile. Although contribution of CLIP2 to the phenotype cannot be excluded when it is deleted in combination with other genes, our results support the hypothesis that GTF2IRD1 and GTF2I are the main genes causing the cognitive defects associated with Williams-Beuren syndrome. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

GLACIER MONITORING SYSTEM IN COLOMBIA - complementing glaciological measurements with laser-scanning and ground-penetrating radar surveys

NASA Astrophysics Data System (ADS)

Ceballos, Jorge; Micheletti, Natan; Rabatel, Antoine; Mölg, Nico; Zemp, Michael

2015-04-01

Colombia (South America) has six small glaciers (total glacierized area of 45 Km2); their geographical location, close to zero latitude, makes them very sensitive to climate changes. An extensive monitoring program is being performed since 2006 on two glaciers, with international cooperation supports. This presentation summarizes the results of glacier changes in Colombia and includes the latest results obtained within the CATCOS Project - Phase 1 (Capacity Building and Twinning for Climate Observing Systems) signed between Colombia and Switzerland, and within the Joint Mixte Laboratory GREAT-ICE (IRD - France), with the application of LiDAR technology and GPR-based ice thickness measurements at Conejeras Glacier. Conejeras Glacier (Lat. N. 4° 48' 56"; Long. W. 75° 22' 22"; Alt. Max. 4915m.; Alt. Min. 4730m. Area 0.2 Km2) is located on the north-western side of Santa Isabel Volcano. This glacier belongs to global glacier monitoring network of the World Glacier Monitoring Service (WGMS-ID: 2721). The surface mass balance is calculated monthly using the direct glaciological method. Between April 2006 and May 2014, Conejeras Glacier showed a cumulative loss of -21 m w.e. The CATCOS Project allowed to improve the glacier monitoring system in Colombia with two main actions: (1) a terrestrial laser scanner survey (RIEGL VZ-6000 terrestrial laser scanner, property of Universities of Lausanne and Fribourg); and (2) ice thickness measurements (Blue System Integration Ltd. Ice Penetrating Radar of property of IRD). The terrestrial laser-scanning survey allowed to realize an accurate digital terrain model of the glacier surface with 13 million points and a decimetric resolution. Ice thickness measurements showed an average glacier thickness of 22 meters and a maximum of 52 meters.

ANN based Performance Evaluation of BDI for Condition Monitoring of Induction Motor Bearings

NASA Astrophysics Data System (ADS)

Patel, Raj Kumar; Giri, V. K.

2017-06-01

One of the critical parts in rotating machines is bearings and most of the failure arises from the defective bearings. Bearing failure leads to failure of a machine and the unpredicted productivity loss in the performance. Therefore, bearing fault detection and prognosis is an integral part of the preventive maintenance procedures. In this paper vibration signal for four conditions of a deep groove ball bearing; normal (N), inner race defect (IRD), ball defect (BD) and outer race defect (ORD) were acquired from a customized bearing test rig, under four different conditions and three different fault sizes. Two approaches have been opted for statistical feature extraction from the vibration signal. In the first approach, raw signal is used for statistical feature extraction and in the second approach statistical features extracted are based on bearing damage index (BDI). The proposed BDI technique uses wavelet packet node energy coefficients analysis method. Both the features are used as inputs to an ANN classifier to evaluate its performance. A comparison of ANN performance is made based on raw vibration data and data chosen by using BDI. The ANN performance has been found to be fairly higher when BDI based signals were used as inputs to the classifier.

Comparison for Air Kerma from Radiation Protection Gamma-ray Beams with Brazilian Network - 2016/2017

NASA Astrophysics Data System (ADS)

Cabral, TS; da Silva, CNM; Potiens, MPA; Soares, CMA; Silveira, RR; Khoury, H.; Saito, V.; Fernandes, E.; Cardoso, WF; de Oliveira, HPS; Pires, MA; de Amorim, AS; Balthar, M.

2018-03-01

The results of the comparison involving 9 laboratories in Brazil are reported. The measured quantity was the air kerma in 137Cs and 60Co, at the level of radioprotection. The comparison was conducted by the National Laboratory Metrology of Ionizing Radiation (LNMRI/IRD) from October 2016 to March 2017. The largest deviation between the calibration coefficients was 0.8% for 137Cs and 0.7% for 60Co. This proficiency exercise proved the technical capacity of the Brazilian calibration network in radiation monitors and the results were used by some in the implementation of the standard ISO/IEC 17025.

Results of the first provisional technical secretariat interlaboratory comparison test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stuff, J.R.; Hoffland, L.

1995-06-01

The principal task of this laboratory in the first Provisional Technical Secretariat (PTS) Interlaboratory Comparison Test was to verify and test the extraction and preparation procedures outlined in the Recommended Operating Procedures for Sampling and Analysis in the Verification of Chemical Disarmament in addition to our laboratory extraction methods and our laboratory analysis methods. Sample preparation began on 16 May 1994 and analysis was completed on 12 June 1994. The analytical methods used included NMR ({sup 1}H and {sup 31}P) GC/AED, GC/MS (EI and methane CI), GC/IRD, HPLC/IC, HPLC/TSP/MS, MS/MS(Electrospray), and CZE.

International postseismic response after the Mw=7.8 April 16, 2016 Pedernales Earthquake in Ecuador

NASA Astrophysics Data System (ADS)

Font, Y.; Ruiz, M. C.; Alvarado, A. P.; Mercerat, D.; Beck, S. L.; Leon Rios, S.; Meltzer, A.; Charvis, P.; Regnier, M. M.; Jarrin, P.; Rietbrock, A.; Vasconez, F.; Dionicio, V.; Calvache, M. L.; Singaucho, J. C.; Pazmino, A.; Rolandone, F.; Mothes, P. A.; Nocquet, J. M.; Martin, X.; Viracucha, C.; Audin, L.; Saillard, M.; Laurendeau, A.; Perrault, M.; Garth, T.; Pernoud, M.; Barros, J. G.; Yates, B.; Malengros, D.; Oregioni, D.; Villegas Lanza, J. C.; Cisneros, D.; Gomez, J.; Montes, L.; Beauval, C. M.; Bertrand, E.; Delouis, B.; Ruiz Paspuel, A. G.; Freymueller, J. T.; Williams, K.; La Femina, P.; Fuenzalida, A.; Mariniere, J.; Cheze, J.; Gueguen, P.; Maron, C.; Michaud, F.; Yepes, H. A.; Palacios, P.; Vallee, M.; Deschamps, A.; Gabriela, P.; Ambrois, D.; Ramos, C.; Courboulex, F.

2016-12-01

The Pedernales earthquake is a large Mw7.8 subduction earthquake caused by the relative convergence between the Nazca and South American plates. It occured north of the city of Pedernales, at 21 km depth and struck the coastal and densely populated Manabi Province, causing many casualties, structural damages and widespread surficial deformation. The 2016 epicenter was located near the Mw 7.8 1942 epicenter. Both events are similar in size and probably ruptured the same segment, which also corresponds to the southern part of the 1906 Mw8.8 Ecuador-Colombia megathrust rupture zone. Immediately after the earthquake, an international team from Ecuador, France, Colombia, the United Kingdom, Peru and the United States coordinated a scientific response with the respective financial support of EPN, IRD and CNRS, SGC, NERC and NSF. Equipment was provided by IGEPN, IRD, CEREMA, SGC, LIVERPOOL, IRIS PASSCAL and UNAVCO. Within a 1.5 month, the team progressively deployed a temporary seismic network of about 70 accelerometer and seismic stations, and 17 continuous GPS stations, complementing the permanent seismic, accelerometer and geodetic network of the IG-EPN. The dense network covers the 300 x 150 km wide area affected by the earthquake, including a trench-parallel line of 10 ocean bottom seismometers deployed by the R/V Orion of INOCAR for 6 months, assuring a minimized azimuthal gap. Intense seismicity is observed up to 150 km N- and S-ward from the rupture zone aligning mainly along 3 seismic strips roughly perpendicular to the trench and also near the rupture area. Peak ground and spectral accelerations are compared with existing ground-motion prediction equations (GMPEs) developed for interface earthquakes. Different soil investigations were realized to highlight soil characteristics in cities. The geodetic observations captured the immediate afterslip and will help determining the time history of afterslip and viscoelastic relaxation in response to this earthquake. A field survey was conducted on-land to describe the coseismic tectonic deformations and damages to buildings. At sea, a multibeam bathymetry survey of the margin over the rupture zone was conducted by the R/V Orion, making it possible to tentatively estimate and quantify sea-floor deformation after and before the earthquake.

Bottom water production variability in the Ross Sea slope during the Late Pleistocene-Holocene as revealed by benthic foraminifera and sediment geochemistry

NASA Astrophysics Data System (ADS)

Langone, Leonardo; Asioli, Alessandra; Tateo, Fabio; Giglio, Federico; Ridente, Domenico; Summa, Vito; Carraro, Anna; Luigia Giannossi, Maria; Piva, Andrea; Trincardi, Fabio

2010-05-01

The Antarctic area produces bottom waters that ventilate the vast majority of the deep basins in the rest of the world ocean. The rate of formation in the source area and the strength of these cold bottom waters are key factors affecting the Global Thermohaline Circulation during modern and past climate conditions. The western Ross Sea is considered a formation site for a particularly salty variety of AABW as well as an important area of off-shelf transfer of water as plumes entraining in Lower CDW and as rapid downhill cascades. The results here presented were obtained within the frame of the PNRA project 4.8. Among the goals of the project, the main is to detect a qualitative signal of possible changes in the rate of bottom water production during the Late Pleistocene-Holocene by integrating data on foraminifera assemblages with sediment geochemistry (bulk mineralogy, Total Organic Carbon, biogenic silica, C and N stable isotopes) and IRD. A gravity core was collected at 2377m water depth off Drygalski Basin on the slope adjacent the western continental shelf of the Ross Sea, along the pathway of bottom water spreading. The chronology is based on the best fitting of twelve control points selected among twenty-two 14C AMS datings performed on the bulk organic carbon and 210Pb excess data. The trend of the parameters allows the following observations: 1) two main intervals (15-10 and 7.5-6 cab kyr BP) mark a subsequent enhanced nutrient supply. Indeed, δ15N variations depend on the utilization degree of nitrates, in turn reflecting productivity/nutrient supply changes. The concurrent increase of OC and biogenic silica suggests an increase of the nutrient availability. As the Upper CDW is a water mass rich in nutrients we interpret these intervals as characterized by a higher efficiency in the Upper CDW upwelling; 2) around 7.5-7kyr BP (part of the Middle Holocene Climatic Optimum) the IRD content drops, suggesting the reduction of iceberg production or a change of the iceberg path. Within this general context, an oscillatory trend is present from 15 kyr BP to present time. Two hypotheses are proposed: a) minima in foraminifera concentrations reflect relatively stronger dissolution, weaker bottom currents (minima in dry density) and lower nutrient supply (lighter values of δ15N). These intervals may reflect a lower rate of bottom water formation; the intervals corresponding to maxima in foraminifers concentration should indicate better preservation, higher benthic productivity and/or better oxygenation at bottom, stronger bottom currents (maxima in dry density) and relatively higher nutrient supply reflecting a relatively higher rate of bottom water formation. b) alternatively, minima in foraminifers, corresponding to minima in %OC and to reversal of 14C (relative increase of older carbon), reflect dilution in the sediment because of rapid accumulation of fine sediment re-suspended at the shelf edge by the cascading currents. Therefore, the minima represent higher rate of bottom water formation. The comparison of the D/H ratio in ice-cores from the Ross Sea sector with the core AS05-10 record indicates that the foraminifers minima always correspond to colder condition. This scenario also correlates to the record reported in literature on the slope off Wilkes-Adelie Land. At last, a condensed/hiatus interval at ca. 3.5-4 kyr BP does not seems to mark a major change in the general pattern of our variables, apart from biogenic silica and sheets silicates showing an increase of the oscillation amplitude. Nevertheless, this feature is coeval to the base of the Neoglacial and it is time-equivalent to the beginning of major changes in the Antarctic environment.

High-resolution chronology for deglaciation of the Patagonian Ice Sheet at Lago Buenos Aires (46.5°S) revealed through varve chronology and Bayesian age modelling

NASA Astrophysics Data System (ADS)

Bendle, Jacob M.; Palmer, Adrian P.; Thorndycraft, Varyl R.; Matthews, Ian P.

2017-12-01

Glaciolacustrine varves offer the potential to construct continuous, annually-resolved chronologies for ice-sheet deglaciation, and improved understanding of glacier retreat dynamics. This paper investigates laminated glaciolacustrine sediments deposited around the waning margins of the Patagonian Ice Sheet, following the local Last Glacial Maximum (LGM). Detailed macro- and microfacies analyses confirm an annual (varve) structure within these sediments. The correlation of annual layers (varves) across five sites in eastern Lago Buenos Aires yields a 994 ± 36 varve-year (vyr) chronology and thickness record. The floating chronology has been anchored to the calendar-year timescale through identification of the Ho tephra (17,378 ± 118 cal a BP) in the varve sequences. Using a Bayesian age model to integrate the new varve chronology with published moraine ages, the onset of deglaciation at 46.5°S is dated to 18,086 ± 214 cal a BP. New age estimates for deglacial events are combined with high-resolution analysis of varve thickness trends, and new lithostratigraphic data on ice-margin position(s), to reconstruct ice-margin retreat rates for the earliest ca. 1000 years of ice-sheet demise. Glacier retreat rates were moderate (5.3-10.3 m yr-1) until 17,322 ± 115 cal a BP, but subsequently accelerated (15.4-18.0 m yr-1). Sustained influxes of ice-rafted debris (IRD) after 17,145 ± 122 cal a BP suggest retreat rates were enhanced by calving after ice contracted into deeper lake waters. Ice persisted in eastern Lago Buenos Aires until at least 16,934 ± 116 cal a BP, after which the glacier started to retreat towards the Patagonian mountains.

Diversity and Complexity in Chromatin Recognition by TFII-I Transcription Factors in Pluripotent Embryonic Stem Cells and Embryonic Tissues

PubMed Central

Makeyev, Aleksandr V.; Enkhmandakh, Badam; Hong, Seung-Hyun; Joshi, Pujan; Shin, Dong-Guk; Bayarsaihan, Dashzeveg

2012-01-01

GTF2I and GTF2IRD1 encode a family of closely related transcription factors TFII-I and BEN critical in embryonic development. Both genes are deleted in Williams-Beuren syndrome, a complex genetic disorder associated with neurocognitive, craniofacial, dental and skeletal abnormalities. Although genome-wide promoter analysis has revealed the existence of multiple TFII-I binding sites in embryonic stem cells (ESCs), there was no correlation between TFII-I occupancy and gene expression. Surprisingly, TFII-I recognizes the promoter sequences enriched for H3K4me3/K27me3 bivalent domain, an epigenetic signature of developmentally important genes. Moreover, we discovered significant differences in the association between TFII-I and BEN with the cis-regulatory elements in ESCs and embryonic craniofacial tissues. Our data indicate that in embryonic tissues BEN, but not the highly homologous TFII-I, is primarily recruited to target gene promoters. We propose a “feed-forward model” of gene regulation to explain the specificity of promoter recognition by TFII-I factors in eukaryotic cells. PMID:22970219

Diversity and complexity in chromatin recognition by TFII-I transcription factors in pluripotent embryonic stem cells and embryonic tissues.

PubMed

Makeyev, Aleksandr V; Enkhmandakh, Badam; Hong, Seung-Hyun; Joshi, Pujan; Shin, Dong-Guk; Bayarsaihan, Dashzeveg

2012-01-01

GTF2I and GTF2IRD1 encode a family of closely related transcription factors TFII-I and BEN critical in embryonic development. Both genes are deleted in Williams-Beuren syndrome, a complex genetic disorder associated with neurocognitive, craniofacial, dental and skeletal abnormalities. Although genome-wide promoter analysis has revealed the existence of multiple TFII-I binding sites in embryonic stem cells (ESCs), there was no correlation between TFII-I occupancy and gene expression. Surprisingly, TFII-I recognizes the promoter sequences enriched for H3K4me3/K27me3 bivalent domain, an epigenetic signature of developmentally important genes. Moreover, we discovered significant differences in the association between TFII-I and BEN with the cis-regulatory elements in ESCs and embryonic craniofacial tissues. Our data indicate that in embryonic tissues BEN, but not the highly homologous TFII-I, is primarily recruited to target gene promoters. We propose a "feed-forward model" of gene regulation to explain the specificity of promoter recognition by TFII-I factors in eukaryotic cells.

Panel-based Genetic Diagnostic Testing for Inherited Eye Diseases is Highly Accurate and Reproducible and More Sensitive for Variant Detection Than Exome Sequencing

PubMed Central

Bujakowska, Kinga M.; Sousa, Maria E.; Fonseca-Kelly, Zoë D.; Taub, Daniel G.; Janessian, Maria; Wang, Dan Yi; Au, Elizabeth D.; Sims, Katherine B.; Sweetser, David A.; Fulton, Anne B.; Liu, Qin; Wiggs, Janey L.; Gai, Xiaowu; Pierce, Eric A.

2015-01-01

Purpose Next-generation sequencing (NGS) based methods are being adopted broadly for genetic diagnostic testing, but the performance characteristics of these techniques have not been fully defined with regard to test accuracy and reproducibility. Methods We developed a targeted enrichment and NGS approach for genetic diagnostic testing of patients with inherited eye disorders, including inherited retinal degenerations, optic atrophy and glaucoma. In preparation for providing this Genetic Eye Disease (GEDi) test on a CLIA-certified basis, we performed experiments to measure the sensitivity, specificity, reproducibility as well as the clinical sensitivity of the test. Results The GEDi test is highly reproducible and accurate, with sensitivity and specificity for single nucleotide variant detection of 97.9% and 100%, respectively. The sensitivity for variant detection was notably better than the 88.3% achieved by whole exome sequencing (WES) using the same metrics, due to better coverage of targeted genes in the GEDi test compared to commercially available exome capture sets. Prospective testing of 192 patients with IRDs indicated that the clinical sensitivity of the GEDi test is high, with a diagnostic rate of 51%. Conclusion The data suggest that based on quantified performance metrics, selective targeted enrichment is preferable to WES for genetic diagnostic testing. PMID:25412400

Alternative splicing and promoter use in TFII-I genes.

PubMed

Makeyev, Aleksandr V; Bayarsaihan, Dashzeveg

2009-03-15

TFII-I proteins are ubiquitously expressed transcriptional factors involved in both basal transcription and signal transduction activation or repression. TFII-I proteins are detected as early as at two-cell stage and exhibit distinct and dynamic expression patterns in developing embryos as well as mark regional variation in the adult mouse brain. Analysis of atypical small and rare chromosomal deletions at 7q11.23 points to TFII-I genes (GTF2I and GTF2IRD1) as the prime candidates responsible for craniofacial and cognitive abnormalities in the Williams-Beuren syndrome. TFII-I genes are often subjected to alternative splicing, which generates isoforms that show different activities and play distinct biological roles. The coding regions of TFII-I genes are composed of more than 30 exons and are well conserved among vertebrates. However, their 5' untranslated regions are not as well conserved and all poorly characterized. In the present work, we analyzed promoter regions of TFII-I genes and described their additional exons, as well as tested tissue specificity of both previously reported and novel alternatively spliced isoforms. Our comprehensive analysis leads to further elucidation of the functional heterogeneity of TFII-I proteins, provides hints on search for regulatory pathways governing their expression, and opens up possibilities for examining the effect of different haplotypes on their promoter functions.

Geochemical and sedimentological records of intermediate-depth circulation in the Labrador Sea since the Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Hoffmann, S. S.; Dalsing, R.; McManus, J. F.

2016-12-01

Dynamical sedimentary proxies for deep ocean circulation, such as mean sortable silt size and 231Pa/230Th, allow the reconstruction of past changes in deep water circulation speed and ocean basin ventilation. This provides an important addition to traditional methods of deep water circulation reconstruction such as mapping water mass geometry through foraminiferal carbon isotopic records. We have produced records of mean sortable silt size from three intermediate-depth sediment core sites in the Labrador Sea, taken from the continental slope and Orphan Knoll east of Newfoundland, to reconstruct changes in intermediate depth water circulation including Glacial North Atlantic Intermediate Water and Labrador Sea Water. Radiocarbon dating indicates that the cores span the Holocene, deglaciation and LGM. Increases in mean sortable silt size appear to coincide with Heinrich Event 1, the Older Dryas, Younger Dryas, and mid-late Holocene, which could suggest increased bottom current speeds at these times. However, ice-rafted debris contributes to marine sediments in this region, and mean sortable silt size at times of major IRD input such as Heinrich Event 1 may therefore reflect multiple influences. We will use inverse modeling techniques to determine likely end members contributing to the sortable silt fraction and to correct for the effect of IRD on sortable silt size, allowing a better understanding of the influence of current speed on these samples. We combine these sortable silt measurements with the sedimentary geochemical proxy 231Pa/230Th, which has been used to reconstruct changes in North Atlantic meridional overturning circulation. New 231Pa/230Th data from cores KN158-4-27/28, which provided our best-resolved sortable silt record, will allow us to compare results from the two dynamical proxies to better understand both the behavior of these proxies in the Labrador Sea, and the history of intermediate-depth circulation and ventilation in the Labrador Sea during major abrupt climate events and transitions.

Prominent Optic Disc Featured in Inherited Retinopathy.

PubMed

Todorova, M G; Bojinova, R I; Valmaggia, C; Schorderet, D F

2017-04-01

Background We investigated the relationship between prominent optic disc (POD) and inherited retinal dystrophy (IRD). Patients and Methods A cross-sectional consecutive study was performed in 10 children and 11 adults of 7 non-related families. We performed clinical phenotyping, including a detailed examination, fundus autofluorescence, and colour fundus and OCT imaging. Genetic testing was subsequently performed for all family members presenting retinal pathology. Results In 4 members of a 3-generation family, hyperfluorescent deposits on the surface of POD were related to a p.(L224M) heterozygous mutation in BEST1 . In the second family, one member presented deposits located on the surface on hyperaemic OD and a compound p.(R141H);(A195V) mutation in BEST1 . In the third family, POD was observed in father and child with early onset cone-rod dystrophy and a novel autosomal recessive p.(W31*) homozygous mutation in ABCA4 . In the fourth family, POD with "mulberry-like" deposits and attenuated vessels were observed in a 7-year old girl, with a mutation in USH1A , and with early onset rod-cone dystrophy, associated with hearing loss. In the fifth family, blurry OD with tortuous vessels was observed in 4 consanguineous female carriers and a hemizygous boy with a p.(R200H) mutation in the X-linked retinoschisis RS1 . In the sixth family, a mother and her son were both affected with POD and attenuated peripapillary vessels, and presented with a p.(Y836C) heterozygous mutation in TOPORS , thus confirming autosomal dominant RP. In the seventh family, in 3 family members with POD, compound p.(L541P;A1038 V);(G1961E) mutations in ABCA4 confirmed the diagnosis of Stargardt disease. Conclusions A variety of OD findings are found in a genetically heterogeneous group of IRDs. In the presence of POD, an inherited progressive photoreceptor disease should be ruled out. Georg Thieme Verlag KG Stuttgart · New York.

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra.

PubMed

Mohamed, Ekram H; Lotfy, Hayam M; Hegazy, Maha A; Mowaka, Shereen

2017-05-25

Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different novel and smart spectrophotometric techniques for resolution of severely overlapping spectra were presented in this work utilizing isosbestic points present in different absorption spectra, normalized spectra as a divisor and dual wavelengths. A quaternary mixture of drotaverine (DRO), caffeine (CAF), paracetamol (PCT) and para-aminophenol (PAP) was taken as an example for application of the proposed techniques without any separation steps. The adopted techniques adopted of successive and progressive steps manipulating zero /or ratio /or derivative spectra. The proposed techniques includes eight novel and simple methods namely direct spectrophotometry after applying derivative transformation (DT) via multiplying by a decoding spectrum, spectrum subtraction (SS), advanced absorbance subtraction (AAS), advanced amplitude modulation (AAM), simultaneous derivative ratio (S 1 DD), advanced ratio difference (ARD), induced ratio difference (IRD) and finally double divisor-ratio difference-dual wavelength (DD-RD-DW) methods. The proposed methods were assessed by analyzing synthetic mixtures of the studied drugs. They were also successfully applied to commercial pharmaceutical formulations without interference from other dosage form additives. The methods were validated according to the ICH guidelines, accuracy, precision, repeatability, were found to be within the acceptable limits. The proposed procedures are accurate, simple and reproducible and yet economic. They are also sensitive and selective and could be used for routine analysis of complex most of the binary, ternary and quaternary mixtures and even more complex mixtures.

Sedimentology of cores recovered from the Canada Basin of the Arctic Ocean

NASA Astrophysics Data System (ADS)

Edwards, B. D.; Saint-Ange, F.; Pohlman, J.; Higgins, J.; Mosher, D. C.; Lorenson, T. D.; Hart, P.

2011-12-01

Researchers from the United States and Canada are collaborating to understand the tectonic and sedimentary history of the Arctic Ocean between Canada and Alaska. As part of this on-going study, a joint US-Canadian ice breaker expedition operated in parts of the Canada Basin during August 2010. Occasional interruptions of the seismic data acquisition provided the ship time to collect gravity and piston cores at five sites-of-opportunity throughout the basin. High-resolution multibeam bathymetry and chirp sub-bottom profiler data collected immediately prior to coring reveal the fine-scale morphology of each site. Core photographs, X-ray radiographs, and physical property data support the following descriptions. Two piston cores were collected from the Beaufort Sea continental margin in a region of known bottom simulating reflectors (BSRs). Site 1 (2538 m water depth): This core recovered 5.72 m of gas-charged, gray sticky clay and silty-clay from an approximately 1100 m diameter, 130 m high conical mound overlying the crest of a buried anticline. Gas hydrate recovered in the core catcher combined with cracks and voids, methane and other hydrocarbon gasses, pyrite concretions, chemosynthetic clams, carbonate nodules, and soft carbonate masses indicate the likely upward migration of deep-seated fluids. Site 2 (1157 m water depth): This core, positioned 40 km upslope from the gas hydrate core, recovered 3 m of gray sticky silty clay and clayey silt near the base of an erosional scarp. Some voids and fracturing are apparent but carbonate masses and pyrite concretions are absent. Site 3 (3070 m water depth): This core from the top of a seamount discovered in 2009 in the north-central part of the Canada Basin recovered 4.94 m of sediment. More than 3 m of dark brown to yellowish brown, massive interbedded silty clays with sands and matrix-supported gravels (ice rafted debris [IRD]) occur in abrupt contact with underlying reddish yellow to brownish yellow silty clay and gravelly sandy clay interpreted to be altered hydrothermally. Successions of IRD layers create a thinly- to medium-bedded sequence throughout the lower section. Site 4 (3700 m water depth; central Canada Basin): This core recovered 3.4 m of sediment typified by decimeter-thick sequences of stacked graded beds with erosional basal contacts (Bouma sequences) characteristic of turbidite deposition. Site 5 (2081 m water depth; continental slope west of the Canadian archipelago): This core recovered 4.96 m of sediment of which the upper 2 m is silty clay to clayey silt with dispersed sand and granules. This upper section has an irregular, sharp basal contact with an underlying 16-cm-thick clast-supported massive gravel. The gravel has a scoured basal contact and overlies a monotonous gray clayey silt containing dispersed granules of IRD. Sparse and poorly preserved fauna throughout all the cores make age determination difficult; however, given the paucity of sediment cores in the Arctic Ocean, these samples provide vital geophysical groundtruth and sedimentological information about the basin.

3D anatomy of Heinrich Layer 2

NASA Astrophysics Data System (ADS)

van Rooij, D.; Zaazi, N.; Fagel, N.; Boone, M.; Cnudde, V.; Dewanckele, J.; Pirlet, H.; Rohl, U.; Blamart, D.; Henriet, J.-P.; Jacobs, P.; Houbrechts, H.; Duyck, P.; Swennen, R.

2009-04-01

Heinrich Layers are found in the North Atlantic Ocean as well-constrained markers of catastrophic iceberg surges from the Pan-Atlantic ice sheets during the last glacial cycle. Their physical and geochemical characteristics allow for relatively fast diagnostics using the state-of-the-art core scanners such as a Multi-Sensor Core Logger and an XRF core scanner. The nature of these characteristics are predominantly due to the source sediments of the ice-rafted debris (IRD) on the one hand (magnetic susceptibility, color, carbonate content) and the response of the palaeo-environment on the other hand (carbonate content, foraminiferal assemblage). However, changes in (gamma) bulk density of the sediment within a Heinrich Layer cannot solely be explained due to the higher content of IRD. Sediment cores in the Porcupine Seabight (West off Ireland) have shown the presence of Heinrich Events without the diagnostic changes in magnetic susceptibility (MS), suggesting a more drastic change in oceanography which could cause widespread diagenesis on the seabed during Heinrich Events. In order to better understand the physical behavior of a Heinrich Layer, 2 cores were studied taken from the northern Porcupine Seabight by R/V Marion Dufresne campaign MD123 in September 2001. More specifically HL2 was studied since it carries the most typical HL signature. The main anatomical information, with a resolution of 0.5 mm, was obtained by means of medical computed tomography of half-core sections of 50 cm length from the Ghent University Hospital. This information was used for detailed sampling for mineralogy, grainsize measurements and palaeoenvironmental analyses. On one core section, XRF core scanning was performed at a 0.5 cm interval. Higher-resolution information was obtained from five 8 cc subsamples which underwent µCT scanning and cold-cathode luminescence microscopy. The results of this unique approach show a rather surprising 3D view of a Heinrich Layer. As expected, the concentration of ice-rafted debris (commonly referred to as the fraction > 150 µm) increases towards the culmination of HL2, marked by an increase in MS, XRF Ca and the percentage of N. pachyderma s. However, the zone where the density increases is marked by a cloud of fine and highly dense particles surrounding the IRD. It seems as if the fine clayey "background" matrix throughout the core consolidates near the centre of HL2. The same feature has been observed within the µCT samples, where the cold-cathode luminescence microscopy has indicated the presence of zoned dolomites. These dolomites might be the result of a diagenetic process that might explain the elevated density. Moreover, the mineralogical analyses show for a predominant volcanic source for the magnetic susceptibility. Contrastingly, both XRF Fe and Ti show significant decreases near the HL culmination, which calls again for diagenetic alteration of the sediment during or just after the Heinrich Event. At this stage of the research, the mechanisms of these diagenetic processes remain unclear. Nevertheless, these results call for a wider view on the depositional processes of Heinrich Layers and their impact upon the seabed geochemistry.

Timing of insolation forcing, CO2 and sea level changes around the current and last four interglacial periods

NASA Astrophysics Data System (ADS)

Kawamura, K.; Aoki, S.; Nakazawa, T.; Abe-Ouchi, A.; Saito, F.

2013-12-01

Investigation of the roles of different forcings (e.g. orbital variations and greenhouse gases) on climate and sea level requires a paleoclimate chronology with high accuracy. Such a chronology for the past 360 ky was constructed through orbital tuning of O2/N2 ratio of trapped air in the Dome Fuji and Vostok ice cores with local summer insolation (Kawamura et al., 2007). We extend the O2/N2 chronology back to ~500 kyr by analyzing the second Dome Fuji ice core, and find the duration of 11 ka, 5 ka, 9 ka, and 20 ka for MIS 5e, 7e, 9e and 11c interglacial periods in Antarctica, with similar variations in atmospheric CO2. The termination timings are consistent with the rising phase of Northern Hemisphere summer insolation. Marine sediment cores from northern North Atlantic contain millennial-scale signatures in various proxy records (e.g. SST, IRD), including abrupt climatic shifts and bipolar seesaw. Based on the bipolar correlation of millennial-scale events, it is possible to transfer our accurate chronology to marine cores from the North Atlantic. As a first attempt, we correlate the planktonic δ18O and IRD records from the marine core ODP 980 with the ice-core δ18O and CH4 around MIS 11. We find that the durations of interglacial plateaus of planktonic δ18O (proxy for sea surface environments) and benthic δ18O (proxy for ice volume and deep-sea temperature) for MIS 11c are 20 and 15 ka, respectively, which are significantly shorter than originally suggested. These durations are similar to that of Antarctic climate and atmospheric CO2. However, the onsets of interglacial levels in ODP980 for MIS 11 are significantly later than those in Antarctic δ18O and atmospheric CO2 (by as much as ~10 ka), suggesting very long duration (more than one precession cycle) for the complete deglaciation and northern high-latitude warming for Termination V. Atmospheric CO2 may have been the critical forcing for this termination. The long duration of Termination V is consistent with our new ice sheet simulations (extended from the work of Abe-Ouchi et al., 2013) in which an ice-sheet/climate model is forced by insolation and CO2 variations. In the presentation, comparisons for other interglacial periods will also be reported.

Ar-Ar Ages of Detrital Hornblendes from Glacial Sediments of the North Sea Trough Mouth Fan

NASA Astrophysics Data System (ADS)

Hemming, S. R.; Haflidason, H.; Sejrup, H. P.

2007-12-01

Determining the relative timing of major iceberg calving from different ice sheet margins around the North Atlantic remains an important goal that will lead to a better understanding of causes and consequences of rapid climate variability during the last glacial period. Characterization of the composition of potential contributors is a necessary step towards this goal. The North Sea trough mouth fan is one of the largest glaciogenic debris flow complexes in the North Atlantic/Arctic region, with an approximate area of 142,000 square km (King et al., 1998, Marine Geology v. 152, pp. 217-246; Nygard et al., 2007, Geology, pp. 395-398). The large ice stream trough crosses the shelf along the southern margin of Norway. The crystalline rocks along the southern margin of Norway are Grenville (approximately 1 Ga old orogen). We undertook a study of the Ar-Ar age populations of individual detrital hornblende grains from a sediment sample of the glacigenic debris lobe created during the last phases of the last glacial maximum from the North Sea trough mouth fan. The goal is to test the hypothesis that the ice stream that fed this fan is the source of abundant Grenville age grains found on Bjorn drift site ODP984, at times when North American Grenville sources are not found in the North Atlantic ice rafted detritus belt (Hemming et al., 2005, AGU Spring meeting, PP23A-04). Hornblende grains from North Sea TMF core NH071-B01\\SC1 (1) (63.24N, 3.36E, 1049m) have a dominant age population of Grenville (921 Ma, 19 of 48 grains) with subordinate populations of 1108 Ma (n=3) and 1779 Ma (n=4). Accordingly they lend support to the hypothesis that this ice stream could be the source of IRD on the Bjorn drift. These results could additionally shed light on the pathways of fine grain sediment transport to the Bjorn drift which would contribute a better understanding of sediment processes in the region. For example, the provenance implied for the IRD by the Ar-Ar hornblende ages is consistent with that implied by the Nd isotope data from fine grained sediments reported for glacial intervals by DePaolo et al. (2006, EPSL, v. 298, pp. 394- 410). It is well known that much of the debris carried by icebergs is fine grained, and thus this provenance match suggests that it is likely that much of the fine grained material may also be carried to this site by icebergs.

Statistical Aspects of Ice Gouging on the Alaskan Shelf of the Beaufort Sea,

DTIC Science & Technology

1983-09-01

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Data Element Dictionary of Five Federal Agencies’ Systems for Processing of Technical Report Literature

DTIC Science & Technology

1983-01-01

ELZRNT: kepozt CI&MlflcatiOm SOU* cft AGENCY: DYUC OSI: flaadatory C, x f cato itadlcto. the degree of protectloo rq~ird age Acatof t alo di Řs0 14...03 ELS9 704T £33 &AC12COMPATISLA UNIOZUGS. ONE fiulflckiO6:. ’LITL AhL 0133 iViOAJS905Z ൕ.X2 A&W (3KW&95.’) MAR iQ .4322.18.1u -IEI 39UAS AML Mk...WOhiI oilo xis 11 ALLA.n iN 30353. Sot$ !IUPOAAI DATA 11 DOW=I3on AMl £MCLObSD hI~dh 66"AS 9BACASX K34 . *NTNUvAL Tag: $If

Identification of the TFII-I family target genes in the vertebrate genome.

PubMed

Chimge, Nyam-Osor; Makeyev, Aleksandr V; Ruddle, Frank H; Bayarsaihan, Dashzeveg

2008-07-01

GTF2I and GTF2IRD1 encode members of the TFII-I transcription factor family and are prime candidates in the Williams syndrome, a complex neurodevelopmental disorder. Our previous expression microarray studies implicated TFII-I proteins in the regulation of a number of genes critical in various aspects of cell physiology. Here, we combined bioinformatics and microarray results to identify TFII-I downstream targets in the vertebrate genome. These results were validated by chromatin immunoprecipitation and siRNA analysis. The collected evidence revealed the complexity of TFII-I-mediated processes that involve distinct regulatory networks. Altogether, these results lead to a better understanding of specific molecular events, some of which may be responsible for the Williams syndrome phenotype.

NASA TechPort Entry for Coiled Brine Recovery Assembly (CoBRA) CL IR&D Project

NASA Technical Reports Server (NTRS)

Pensinger, Stuart

2014-01-01

The Coiled Brine Recovery Assembly (CoBRA) project will result in a proof-of-concept demonstration for a lightweight, compact, affordable, regenerable and disposable solution to brine water recovery. The heart of CoBRA is an evaporator that produces water vapor from brine. This evaporator leverages a novel design that enables passive transport of brine from place to place within the system. While it will be necessary to build or modify a system for testing the CoBRA concept, the emphasis of this project will be on developing the evaporator itself. This project will utilize a “test early, test often” approach, building at least one trial evaporator to guide the design of the final product.

Liquid Therapy Delivery Models Using Microfluidic Airways

NASA Astrophysics Data System (ADS)

Mulligan, Molly K.; Grotberg, James B.; Waisman, Dan; Filoche, Marcel; Sznitman, Josué

2013-11-01

The propagation and break-up of viscous and surfactant-laden liquid plugs in the lungs is an active area of research in view of liquid plug installation in the lungs to treat a host of different pulmonary conditions. This includes Infant Respiratory Distress Syndrome (IRDS) the primary cause of neonatal death and disability. Until present, experimental studies of liquid plugs have generally been restricted to low-viscosity Newtonian fluids along a single bifurcation. However, these fluids reflect poorly the actual liquid medication therapies used to treat pulmonary conditions. The present work attempts to uncover the propagation, rupture and break-up of liquid plugs in the airway tree using microfluidic models spanning three or more generations of the bronchiole tree. Our approach allows the dynamics of plug propagation and break-up to be studied in real-time, in a one-to-one scale in vitro model, as a function of fluid rheology, trailing film dynamics and bronchial tree geometry. Understanding these dynamics are a first and necessary step to deliver more effectively boluses of liquid medication to the lungs while minimizing the injury caused to epithelial cells lining the lungs from the rupture of such liquid plugs.

Patterning roadmap: 2017 prospects

NASA Astrophysics Data System (ADS)

Neisser, Mark

2017-06-01

Road mapping of semiconductor chips has been underway for over 20 years, first with the International Technology Roadmap for Semiconductors (ITRS) roadmap and now with the International Roadmap for Devices and Systems (IRDS) roadmap. The original roadmap was mostly driven bottom up and was developed to ensure that the large numbers of semiconductor producers and suppliers had good information to base their research and development on. The current roadmap is generated more top-down, where the customers of semiconductor chips anticipate what will be needed in the future and the roadmap projects what will be needed to fulfill that demand. The More Moore section of the roadmap projects that advanced logic will drive higher-resolution patterning, rather than memory chips. Potential solutions for patterning future logic nodes can be derived as extensions of `next-generation' patterning technologies currently under development. Advanced patterning has made great progress, and two `next-generation' patterning technologies, EUV and nanoimprint lithography, have potential to be in production as early as 2018. The potential adoption of two different next-generation patterning technologies suggests that patterning technology is becoming more specialized. This is good for the industry in that it lowers overall costs, but may lead to slower progress in extending any one patterning technology in the future.

The 'PUCE CAFE' Project: the First 15K Coffee Microarray, a New Tool for Discovering Candidate Genes correlated to Agronomic and Quality Traits

PubMed Central

2011-01-01

Background Understanding the genetic elements that contribute to key aspects of coffee biology will have an impact on future agronomical improvements for this economically important tree. During the past years, EST collections were generated in Coffee, opening the possibility to create new tools for functional genomics. Results The "PUCE CAFE" Project, organized by the scientific consortium NESTLE/IRD/CIRAD, has developed an oligo-based microarray using 15,721 unigenes derived from published coffee EST sequences mostly obtained from different stages of fruit development and leaves in Coffea Canephora (Robusta). Hybridizations for two independent experiments served to compare global gene expression profiles in three types of tissue matter (mature beans, leaves and flowers) in C. canephora as well as in the leaves of three different coffee species (C. canephora, C. eugenoides and C. arabica). Microarray construction, statistical analyses and validation by Q-PCR analysis are presented in this study. Conclusion We have generated the first 15 K coffee array during this PUCE CAFE project, granted by Génoplante (the French consortium for plant genomics). This new tool will help study functional genomics in a wide range of experiments on various plant tissues, such as analyzing bean maturation or resistance to pathogens or drought. Furthermore, the use of this array has proven to be valid in different coffee species (diploid or tetraploid), drastically enlarging its impact for high-throughput gene expression in the community of coffee research. PMID:21208403

The 'PUCE CAFE' Project: the first 15K coffee microarray, a new tool for discovering candidate genes correlated to agronomic and quality traits.

PubMed

Privat, Isabelle; Bardil, Amélie; Gomez, Aureliano Bombarely; Severac, Dany; Dantec, Christelle; Fuentes, Ivanna; Mueller, Lukas; Joët, Thierry; Pot, David; Foucrier, Séverine; Dussert, Stéphane; Leroy, Thierry; Journot, Laurent; de Kochko, Alexandre; Campa, Claudine; Combes, Marie-Christine; Lashermes, Philippe; Bertrand, Benoit

2011-01-05

Understanding the genetic elements that contribute to key aspects of coffee biology will have an impact on future agronomical improvements for this economically important tree. During the past years, EST collections were generated in Coffee, opening the possibility to create new tools for functional genomics. The "PUCE CAFE" Project, organized by the scientific consortium NESTLE/IRD/CIRAD, has developed an oligo-based microarray using 15,721 unigenes derived from published coffee EST sequences mostly obtained from different stages of fruit development and leaves in Coffea Canephora (Robusta). Hybridizations for two independent experiments served to compare global gene expression profiles in three types of tissue matter (mature beans, leaves and flowers) in C. canephora as well as in the leaves of three different coffee species (C. canephora, C. eugenoides and C. arabica). Microarray construction, statistical analyses and validation by Q-PCR analysis are presented in this study. We have generated the first 15 K coffee array during this PUCE CAFE project, granted by Génoplante (the French consortium for plant genomics). This new tool will help study functional genomics in a wide range of experiments on various plant tissues, such as analyzing bean maturation or resistance to pathogens or drought. Furthermore, the use of this array has proven to be valid in different coffee species (diploid or tetraploid), drastically enlarging its impact for high-throughput gene expression in the community of coffee research.

Alternative splicing and promoter use in TFII-I genes

PubMed Central

Makeyev, Aleksandr V.; Bayarsaihan, Dashzeveg

2008-01-01

TFII-I proteins are ubiquitously expressed transcriptional factors involved in both basal transcription and signal transduction activation or repression. TFII-I proteins are detected as early as at two-cell stage and exhibit distinct and dynamic expression patterns in developing embryos as well as mark regional variation in the adult mouse brain. Analysis of atypical small and rare chromosomal deletions at 7q11.23 points to TFII-I genes (GTF2I and GTF2IRD1) as the prime candidates responsible for craniofacial and cognitive abnormalities in the Williams-Beuren syndrome. TFII-I genes are often subjected to alternative splicing, which generates isoforms that that show different activities and play distinct biological roles. The coding regions of TFII-I genes are composed of more than 30 exons and are well conserved among vertebrates. However, their 5′ untranslated regions are not as well conserved and all poorly characterized. In the present work, we analyzed promoter regions of TFII-I genes and described their additional exons, as well as tested tissue specificity of both previously reported and novel alternatively spliced isoforms. Our comprehensive analysis leads to further elucidation of the functional heterogeneity of TFII-I proteins, provides hints on search for regulatory pathways governing their expression, and opens up possibilities for examining the effect of different haplotypes on their promoter functions. PMID:19111598

Applications for evaluation of physical properties - An example of siliceous rock permeability -

NASA Astrophysics Data System (ADS)

Ojima, T.

2015-12-01

ODP Leg. 186, two sites (Site 1150 and Site 1151) were drilled on the continental slope of the deep-sea forearc basin of northern Japan. Diatomaceous sediments were recovered Site 1150 and Site 1151, and the depth of each site is 1181.60 mbsf and 1113.60 mbsf, respectively. This area is under the influence of the Oyashio current and is one of the highly bio-productive regions of the North Pacific Ocean (Motoyama et al., 2004). The combination of high productivity and active tectonic deformation that often caused high rate accumulating of fossil and organic rich sediments. Likewise, IODP Exp. 341 was implemented on off South Alaska. Pelagic and MTD 's layer were recognized with IRD(Ice Rafted Debris). In Tohoku, The onboard results of porosity measurements show high value (50-70 %) down to 1000 mbsf, and obviously higher than nearby subduction trench, Nankai Trough (Taylor and Fisher, 1993). There is a possibility that diatomaceous shell keep a frame structure from effective stress and load pressure. On another drilling site result, DSDP Leg. 19 located 60 km to the north of ODP sites, was reported high value of porosity, but recognized only shallow range (>500 mbsf) (Shephard and Bryant, 1980). Also, South Alaska sediments show high sedimentation rate and cyclic MTD's Layer. Permeability was lower than Tohoku sediments in spite of upper depth. We focused on the relationships between physical property, microstructure, and logging data at deep range(-1000 mbsf). Logging data were collected using wireline logging (Sacks and Suyehiro, 2003; IODP Prel. Rept., 341., 2014). Based on these results, it is expected that microstructure and logging can be integrated into a general model of core-log correlation. In this presentation, We show results of microstructure using SEM, measured physical properties, and wireline logging data, respectively.

Applicability of SREM to the Verification of Management Information System Software Requirements. Volume II.

DTIC Science & Technology

1981-04-30

f --tlu Final-Report: Applicability of SREM to the Verification of Management Information System Software Requirements, wtch was prepared for the Army...MA _________ TO ________ UTA 1ASE ___________ StMZ25. 70.aC. .. 3CA, c(ie m(Sl f :~ rin I : ruq in SBII Z tSI. M 4.7/.3 69.9 . MA S U/WA0 1.241.5 96.8...IR.D iTEM B-2 C4 .4 . I.I z- 0 44 f - U l c- I ao V. a, I. vv!N0 ~ q * a - i= - a ~ ePcu m ~ bft 0 = z z z z z Uz 4 P4 -F5 zz - -4 zzz z C6 z c. 0. 4 4 v

Precise Analysis of an Optimal Perturbation Estimation and Control Problem.

DTIC Science & Technology

1980-09-15

Washington, DC 20375 A)AI/,.~ ~6 Program Element 61 153N US #T Proiect RR 140241 IL. CONTROLLING OFFICE NAMIE AND ADDRESS 12. REPORT DATE Office of Naval...Now, for s >i 0 and k > 0, < + 2k-J + 2 + oji7 /U1+3r2 2+61J12 ( Sf S2 2 2 1++o2,lhW2++ , Ji 3 JI ~~-0 ISIII I I - < 2k I, W.W. WILLMAN Since 2 1, Isi...8217’ Since Iq I < 3/b by assumption, the integral in Eq. (46) is bounded by f ~ic2I1+h Ibll-r+3ko1Il2K u+ 61 -r + 21 I-rd by the triangle inequality and

Modulation Role of Abscisic Acid (ABA) on Growth, Water Relations and Glycinebetaine Metabolism in Two Maize (Zea mays L.) Cultivars under Drought Stress

PubMed Central

Zhang, Lixin; Gao, Mei; Hu, Jingjiang; Zhang, Xifeng; Wang, Kai; Ashraf, Muhammad

2012-01-01

The role of plant hormone abscisic acid (ABA) in plants under drought stress (DS) is crucial in modulating physiological responses that eventually lead to adaptation to an unfavorable environment; however, the role of this hormone in modulation of glycinebetaine (GB) metabolism in maize particularly at the seedling stage is still poorly understood. Some hydroponic experiments were conducted to investigate the modulation role of ABA on plant growth, water relations and GB metabolism in the leaves of two maize cultivars, Zhengdan 958 (ZD958; drought tolerant), and Jundan 20 (JD20; drought sensitive), subjected to integrated root-zone drought stress (IR-DS) simulated by the addition of polyethylene glycol (PEG, 12% w/v, MW 6000). The IR-DS substantially resulted in increased betaine aldehyde dehydrogenase (BADH) activity and choline content which act as the key enzyme and initial substrate, respectively, in GB biosynthesis. Drought stress also induced accumulation of GB, whereas it caused reduction in leaf relative water content (RWC) and dry matter (DM) in both cultivars. The contents of ABA and GB increased in drought-stressed maize seedlings, but ABA accumulated prior to GB accumulation under the drought treatment. These responses were more predominant in ZD958 than those in JD20. Addition of exogenous ABA and fluridone (Flu) (ABA synthesis inhibitor) applied separately increased and decreased BADH activity, respectively. Abscisic acid application enhanced GB accumulation, leaf RWC and shoot DM production in both cultivars. However, of both maize cultivars, the drought sensitive maize cultivar (JD20) performed relatively better than the other maize cultivar ZD958 under both ABA and Flu application in view of all parameters appraised. It is, therefore, concluded that increase in both BADH activity and choline content possibly resulted in enhancement of GB accumulation under DS. The endogenous ABA was probably involved in the regulation of GB metabolism by regulating BADH activity, and resulting in modulation of water relations and plant growth under drought, especially in the drought sensitive maize cultivar JD20. PMID:22489148

Glacial terminations and the Last Interglacial in the Okhotsk Sea; Their implication to global climatic changes

NASA Astrophysics Data System (ADS)

Gorbarenko, Sergey; Velivetskaya, Tatyana; Malakhov, Mikhail; Bosin, Aleksandr

2017-05-01

Paleoclimate data from the Okhotsk Sea (OS) over Terminations II and I (TII, TI), and the Last and Present Interglacial (LIG, PIG) periods were compiled in order to examine Northern Hemisphere climate and sea level changes. Based on records of four AMS 14C-dated OS cores over TI-PIG, it is argued that the OS productivity/climate, IRD (ice-rafted debris), and benthic foraminiferal oxygen isotope (δ18Obf) proxies provide representative and in-phase evidence of the Northern Hemisphere climate and continental ice sheet changes consistent with the LR 04 δ18Obf curve. Chronologies for two central OS cores over TII-LIG-cooling event 23 (C23) were constructed by correlating OS productivity proxies with well-dated δ18O records of Chinese speleothems because OS environment is modulated by East Asian Monsoon; and, as well as correlating measured magnetic paleointensity excursions with those in the dated PISO-1500 paleointensity stack. Results show several OS climatic and environment states, including TII coeval with Asian Weak Monsoon Interval (WMI) II since 136 ka, LIG with a sharp two-step transition (130.2-129 ka) and demise at С25 (116.5 ka), and last glaciation with coolings at C24 (111 ka) and C23. The OS productivity and IRD records demonstrate certain climate amelioration in the middle of WMI-II, and two insignificant cooling events inside the LIG marked by C27 (126 ka) and C26 (120.6 ka). OS δ18Obf records of both cores demonstrate a gradual trend of lighter values since around 131.5 ka BP, continuing from the onset of LIG (129 ka) to minimum values at 126 ka BP (C27), then nearly constant values until 121.5 ka, followed by a slight increase up to 120.6 ka (C26), and a subsequent strong increase up to 116.5 ka (C25). The magnitude of OS δ18Obf oscillations is 1.35‰, which is less than those in the N. Atlantic. It may therefore be suggested that this OS index probably tracks changes in continental ice sheet volume and sea level.

Ground reaction force adaptations during cross-slope walking and running.

PubMed

Damavandi, Mohsen; Dixon, Philippe C; Pearsall, David J

2012-02-01

Though transversely inclined (cross-sloped) surfaces are prevalent, our understanding of the biomechanical adaptations required for cross-slope locomotion is limited. The purpose of this study was to examine ground reaction forces (GRF) in cross-sloped and level walking and running. Nine young adult males walked and ran barefoot along an inclinable walkway in both level (0°) and cross-slope (10°) configurations. The magnitude and time of occurrence of selected features of the GRF were extracted from the force plate data. GRF data were collected in level walking and running (LW and LR), inclined walking and running up-slope (IWU and IRU), and down-slope (IWD and IRD), respectively. The GRF data were then analyzed using repeated measures MANOVA. In the anteroposterior direction, the timing of the peak force values differed across conditions during walking (p=.041), while the magnitude of forces were modified across conditions for running (p=.047). Most significant differences were observed in the mediolateral direction, where generally force values were up to 390% and 530% (p<.001) larger during the cross-slope conditions compared to level for walking and running, respectively. The maximum force peak during running occurred earlier at IRU compared to the other conditions (p≤.031). For the normal axis a significant difference was observed in the first maximum force peak during walking (p=.049). The findings of this study showed that compared to level surfaces, functional adaptations are required to maintain forward progression and dynamic stability in stance during cross-slope walking and running. Copyright © 2011 Elsevier B.V. All rights reserved.

GénoPlante-Info (GPI): a collection of databases and bioinformatics resources for plant genomics

PubMed Central

Samson, Delphine; Legeai, Fabrice; Karsenty, Emmanuelle; Reboux, Sébastien; Veyrieras, Jean-Baptiste; Just, Jeremy; Barillot, Emmanuel

2003-01-01

Génoplante is a partnership program between public French institutes (INRA, CIRAD, IRD and CNRS) and private companies (Biogemma, Bayer CropScience and Bioplante) that aims at developing genome analysis programs for crop species (corn, wheat, rapeseed, sunflower and pea) and model plants (Arabidopsis and rice). The outputs of these programs form a wealth of information (genomic sequence, transcriptome, proteome, allelic variability, mapping and synteny, and mutation data) and tools (databases, interfaces, analysis software), that are being integrated and made public at the public bioinformatics resource centre of Génoplante: GénoPlante-Info (GPI). This continuous flood of data and tools is regularly updated and will grow continuously during the coming two years. Access to the GPI databases and tools is available at http://genoplante-info.infobiogen.fr/. PMID:12519976

Glacier shrinkage and water resources in the Andes

NASA Astrophysics Data System (ADS)

Francou, Bernard; Coudrain, Anne

For more than a century glaciers around the world have been melting as air temperatures rise due to a combination of natural processes and human activity. The disappearance of these glaciers can have wide-ranging effects, such as the creation of new natural hazards or changes in stream flow that could threaten water suppliesSome of the most dramatic melting has occurred in the Andes mountain range in South America. To highlight the climatic and glacial change in the Andes and to encourage the scientific community to strengthen the glacier observation network that stretches from Colombia to the Patagonian ice fields, the Instituto Nacional de Recursos Naturales (INRENA), Perú, and the Institute of Research and Development (IRD), France, recently organized the second Symposium on Mass Balance of Andean Glaciers in Huaráz,Perú.

Genotypic analysis of X-linked retinoschisis in Western Australia.

PubMed

Lamey, Tina; Laurin, Sarina; Chelva, Enid; De Roach, John

2010-01-01

X-linked Retinoschisis is a leading cause of juvenile macular degeneration. Four Western Australian families affected by X-Linked Retinoschisis were analysed using DNA and clinical information from the Australian Inherited Retinal Disease (IRD) Register and DNA Bank. By direct sequencing of the RS1 gene, three genetic variants were identified; 52+1G > T, 289T > G and 416delA. 289T > G has not been previously reported and is likely to cause a substitution of a membrane binding residue (W92G) in the functional discoidin domain. All clinically diagnosed individuals showed typical electronegative ERGs. The 52+1G > T obligate carrier also recorded a bilaterally abnormal rod ERG and mildly abnormal photopic responses. mfERG trace arrays showed reduced response densities in the paramacular region extending futher temporally for each eye.

Biogenic magnetite, detrital hematite, and relative paleointensity in Quaternary sediments from the Southwest Iberian Margin

NASA Astrophysics Data System (ADS)

Channell, J. E. T.; Hodell, D. A.; Margari, V.; Skinner, L. C.; Tzedakis, P. C.; Kesler, M. S.

2013-08-01

Magnetic properties of late Quaternary sediments on the SW Iberian Margin are dominated by bacterial magnetite, observed by transmission electron microscopy (TEM), with contributions from detrital titanomagnetite and hematite. Reactive hematite, together with low organic matter concentrations and the lack of sulfate reduction, lead to dissimilatory iron reduction and availability of Fe(II) for abundant magnetotactic bacteria. Magnetite grain-size proxies (κARM/κ and ARM/IRM) and S-ratios (sensitive to hematite) vary on stadial/interstadial timescales, contain orbital power, and mimic planktic δ18O. The detrital/biogenic magnetite ratio and hematite concentration are greater during stadials and glacial isotopic stages, reflecting increased detrital (magnetite) input during times of lowered sea level, coinciding with atmospheric conditions favoring hematitic dust supply. Magnetic susceptibility, on the other hand, has a very different response being sensitive to coarse detrital multidomain (MD) magnetite associated with ice-rafted debris (IRD). High susceptibility and/or magnetic grain-size coarsening, mark Heinrich stadials (HS), particularly HS2, HS3, HS4, HS5, HS6 and HS7, as well as older Heinrich-like detrital layers, indicating the sensitivity of this region to fluctuations in the position of the polar front. Relative paleointensity (RPI) records have well-constrained age models based on planktic δ18O correlation to ice-core chronologies, however, they differ from reference records (e.g. PISO) particularly in the vicinity of glacial maxima, mainly due to inefficient normalization of RPI records in intervals of enhanced hematite input.

Development of a Deployable Nonmetallic Boom for Reconfigurable Systems of Small Spacecraft

NASA Technical Reports Server (NTRS)

Rehnmark, Fredrik; Pryor, Mark; Holmes, Buck; Schaechter, David; Pedreiro, Nelson; Carrington, Connie

2007-01-01

In 2005, NASA commenced Phase 1 of the Modular Reconfigurable High Energy Technology Demonstrator (MRHE) program to investigate reconfigurable systems of small spacecraft. During that year, Lockheed Martin's Advanced Technology Center (ATC) led an accelerated effort to develop a 1-g MRHE concept demonstration featuring robotic spacecraft simulators equipped with docking mechanisms and deployable booms. The deployable boom built for MRHE was the result of a joint effort in which ATK was primarily responsible for developing and fabricating the Collapsible Rollable Tube (CRT patent pending) boom while Lockheed Martin designed and built the motorized Boom Deployment Mechanism (BDM) under a concurrent but separate IR&D program. Tight coordination was necessary to meet testbed integration and functionality requirements. This paper provides an overview of the CRT boom and BDM designs and presents preliminary results of integration and testing to support the MRHE demonstration.

Development and testing of 11- and 24-inch hybrid motors under the joint government/industry IR&D program

NASA Technical Reports Server (NTRS)

Boardman, T. A.; Carpenter, R. L.; Goldberg, B. E.; Shaeffer, C. W.

1993-01-01

Establishment of a test facility and associated 11-in.-diameter motor for hybrid propulsion technology development at NASA's George C. Marshall Space Flight Center is discussed in this paper. Results of twenty 11-in.-diameter motor tests with a UTF-29901 (60 percent polycyclopentadiene, 40 percent hydroxyl-terminated polybutadiene)/gaseous oxygen propellant system are presented. Tests at this scale have developed fuel regression correlations for comparison with results of yet-to-be-completed, 24-in.-diameter motor tests; demonstrated combustion efficiency levels in the 95 percent range for both single- and multiple-port grain configurations; have shown smooth and stable throttling characteristics over flight-type throttle ranges; and have begun to establish criteria for stable combustion in hybrid motors. The testing of 24-in. motors has not as yet been initiated and is not addressed.

Electron temperature diagnostics of aluminium plasma in a z-pinch experiment at the “QiangGuang-1" facility

NASA Astrophysics Data System (ADS)

Li, Mo; Wu, Jian; Wang, Liang-Ping; Wu, Gang; Han, Juan-Juan; Guo, Ning; Qiu, Meng-Tong

2012-12-01

Two curved crystal spectrometers are set up on the “QiangGuang-1" generator to measure the z-pinch plasma spectra emitted from planar aluminum wire array loads. Kodak Biomax-MS film and an IRD AXUVHS5# array are employed to record time-integrated and time-resolved free-bound radiation, respectively. The photon energy recorded by each detector is ascertained by using the L-shell lines of molybdenum plasma. Based on the exponential relation between the continuum power and photon energies, the aluminum plasma electron temperatures are measured. For the time-integrated diagnosis, several “bright spots" indicate electron temperatures between (450 eV ~ 520 eV) ± 35%. And for the time-resolved ones, the result shows that the electron temperature reaches about 800 eV ± 30% at peak power. The system satisfies the demand of z-pinch plasma electron temperature diagnosis on a ~ 1 MA facility.

Applying predictive analytics to develop an intelligent risk detection application for healthcare contexts.

PubMed

Moghimi, Fatemeh Hoda; Cheung, Michael; Wickramasinghe, Nilmini

2013-01-01

Healthcare is an information rich industry where successful outcomes require the processing of multi-spectral data and sound decision making. The exponential growth of data and big data issues coupled with a rapid increase of service demands in healthcare contexts today, requires a robust framework enabled by IT (information technology) solutions as well as real-time service handling in order to ensure superior decision making and successful healthcare outcomes. Such a context is appropriate for the application of real time intelligent risk detection decision support systems using predictive analytic techniques such as data mining. To illustrate the power and potential of data science technologies in healthcare decision making scenarios, the use of an intelligent risk detection (IRD) model is proffered for the context of Congenital Heart Disease (CHD) in children, an area which requires complex high risk decisions that need to be made expeditiously and accurately in order to ensure successful healthcare outcomes.

Improvements in ion reflux: An electrodialytic eluent generation and suppression device for ion chromatography.

PubMed

Elkin, Kyle; Riviello, John; Small, Hamish

2015-07-17

This work describes a membrane based electrodialytic ion reflux device (IRD), which uses water as the pumped phase and integrates isocratic and gradient eluent generation and suppression. The current design incorporates several ion exchange membranes to create discrete chambers for suppression and eluent generation, while isolating the electrodes from the analytical stream. A small volume of recycled water can be used as the pumped phase while continuously refluxing the eluent ions. This current design permits electronically controlled eluent generation of at least 16.4μeq KOHmin(-1), while maintaining low suppressed background conductivity (<0.5μS/cm). The device was operated in gradient or isocratic mode continuously for up to 6 weeks. During this period, over 500 gradient and isocratic injections were performed, showing peak retention time precision below 1.5% RSD. Published by Elsevier B.V.

Geochemical and sedimentological properties of Heinrich layers H2 and H1 off the Hudson Strait ice-surging source areas: ice-rafting vs water-laid down depositional mechanisms

NASA Astrophysics Data System (ADS)

Nuttin, L.; Hillaire-Marcel, C.

2012-12-01

The ~9 m-long core HU08-029-004PC was raised from the lower Labrador Sea slope (2674 m water-depth), approximately 180 km off Hudson Strait shelf edge. It yielded a high resolution record spanning the last 35 ka. The sequence includes layers with abundant detrital carbonates produced by glacial erosion of Paleozoic rocks and released into the Labrador Sea through ice streaming processes in Hudson Strait and Ungava Bay. These layers are assigned to 'Heinrich events' 3 (at core bottom), 2 and 1. Sedimentological properties and U and Th isotope measurements are used to document depositional mechanisms and durations of these layers. Data suggest: i) intense ice-rafting deposition (IRD) due to iceberg calving at the ice-stream edge, as illustrated by the coarse fraction content of the layers, and ii) sub-glacial meltwater flushing over the Hudson Strait sill, carrying fine silt-size, carbonate-rich glacial flour to the shelf-edge. Such suspended sediment pulses led to the spreading of turbidites mostly into the deep Labrador Sea, through the NAMOC system. Others late-glacial events, such as the ~ 8.2 ka final drainage of Lake Agassiz, are also recorded in the study core, whereas the H0 layer, exclusively observed in the western Labrador Sea is missing. CAT-scan images, mineralogical data, carbonate abundance, %>106 μm fraction (mostly IRD here), U-Th isotope data and 14C ages of planktic foraminifera assemblages (Neogloboquadrina pachyderma, l.) are used to further document H2 (760 to 700 cm) and H1 (588 to 488 cm). The H-layers contain up to 60% of fine detrital carbonates (about 2/3 calcite, 1/3 dolomite). Whereas the fine calcitic material points to sediment sources (basal till/water-laid glacial sediments) in the Hudson Strait and Ungava Bay, i.e., originating from the glacial erosion of Paleozoic carbonates from the area, the dolomitic component might have several origins (from Proterozoic and Paleozoic limestones in the Hudson Bay and Strait, to northwestern Baffin Island Paleozoic dolomite sources). The carbonate-rich layers are characterized by 234U/238U activity ratio <1 and more importantly, by very low initial 230Th excesses (230Thxs)0. Such low values indicate extremely fast deposition. An inventory of the (230Thxs)0 has been made based on 13 calibrated 14C ages and then used for interpolating duration ages for the H2 and H1. Estimated of 1.34 and 2.02 ka (vs 1.64 and 2.03 ka 14C), were respectively obtained. Another rapidly deposited layer of fine detrital carbonates-rich sediment yielded an age of about 8.3 ka, suggesting an assignment to the final drainage age of Lake Agassiz. Above this layer, high (230Thxs)0 values, but low (230Thxs)0-fluxes point to much reduced sedimentation rates and possibly focussing deeper slope during the Holocene.

INVOGE (International Geological Masters in Volcanology and geotechniques): a strategy to train and maintain globally mobile geoscientists

NASA Astrophysics Data System (ADS)

van Wyk de Vries, B.; Bion, P.; Rose, W. I.; Tibaldi, A.; Calder, E.; Wooten, K.; Sealing, C.; Menassian, S.

2012-04-01

INVOGE is an EU-US bilateral cooperation programme funded by the EACEA (EU) and FIPSE (US). The partner universities are Blaise Pascal ( UBP, Clermont-Ferrand, France), University of Milan-Bicocca (Italy), Michigan Technological University (US) and the University at Buffalo (US). Students spend one academic year on the opposing side of the Atlantic and a shorter time on mobility at the secondary European partner. The project is a partial merger of four masters programmes that have similar fields of study, but widely differing speciality courses and great cultural and linguistic differences. The partner universities also have major implantations in developing nations, in Latin America and South East Asia, areas from which are drawn a both students and staff. In this presentation we show how we are creating a sustainable structure to train internationally mobile, multilingual geoscientists in both developed and developing nations both within the present INVOGE master and in associated programmes. For example at UBP the newly created CLERVOLC 'laboratoire d'excelence' programme associates research in several domains with the international outreach associated with the Institute for Research and Development (IRD) into the international Masters programme, seamlessly coupling research and education into projects such as INVOGE. The other partner universities are developing similar internconnected international projects. We also will detail the problems related to moving students from widely different backgrounds around culturally and linguistically diverse universities and will discuss how we are tackling such problems, with internet-based courses, language and cultural training for students and staff training, curriculum changes, close student - staff integration into project development and the creation of alumni organisations.

Time-resolved fluorescence imaging of slab gels for lifetime base-calling in DNA sequencing applications.

PubMed

Lassiter, S J; Stryjewski, W; Legendre, B L; Erdmann, R; Wahl, M; Wurm, J; Peterson, R; Middendorf, L; Soper, S A

2000-11-01

A compact time-resolved near-IR fluorescence imager was constructed to obtain lifetime and intensity images of DNA sequencing slab gels. The scanner consisted of a microscope body with f/1.2 relay optics onto which was mounted a pulsed diode laser (repetition rate 80 MHz, lasing wavelength 680 nm, average power 5 mW), filtering optics, and a large photoactive area (diameter 500 microns) single-photon avalanche diode that was actively quenched to provide a large dynamic operating range. The time-resolved data were processed using electronics configured in a conventional time-correlated single-photon-counting format with all of the counting hardware situated on a PC card resident on the computer bus. The microscope head produced a timing response of 450 ps (fwhm) in a scanning mode, allowing the measurement of subnano-second lifetimes. The time-resolved microscope head was placed in an automated DNA sequencer and translated across a 21-cm-wide gel plate in approximately 6 s (scan rate 3.5 cm/s) with an accumulation time per pixel of 10 ms. The sampling frequency was 0.17 Hz (duty cycle 0.0017), sufficient to prevent signal aliasing during the electrophoresis separation. Software (written in Visual Basic) allowed acquisition of both the intensity image and lifetime analysis of DNA bands migrating through the gel in real time. Using a dual-labeling (IRD700 and Cy5.5 labeling dyes)/two-lane sequencing strategy, we successfully read 670 bases of a control M13mp18 ssDNA template using lifetime identification. Comparison of the reconstructed sequence with the known sequence of the phage indicated the number of miscalls was only 2, producing an error rate of approximately 0.3% (identification accuracy 99.7%). The lifetimes were calculated using maximum likelihood estimators and allowed on-line determinations with high precision, even when short integration times were used to construct the decay profiles. Comparison of the lifetime base calling to a single-dye/four-lane sequencing strategy indicated similar results in terms of miscalls, but reduced insertion and deletion errors using lifetime identification methods, improving the overall read accuracy.

Bedrock cores from 89° North: Implications for the geologic framework and Neogene paleoceanography of Lomonosov Ridge and a tie to the Barents shelf

USGS Publications Warehouse

Grantz, Arthur; Pease, Victoria L.; Willard, Debra A.; Phillips, R.L.; Clark, David L.

2001-01-01

Two piston cores from the Eurasian flank of Lomonosov Ridge near lat 88.9°N, long 140°E provide the first samples of bedrock from this high-standing trans-Arctic ridge. Core 94-PC27 sampled nonmarine siltstone similar in facies and age to uppermost Triassic to lower Lower Jurassic and mid– Lower Cretaceous beds in the 4 to > 5 km Mesozoic section on Franz Josef Land, on the outer Barents shelf. A ca. 250 Ma peak in the cumulative frequency curve of detrital zircons from the siltstone, dated by U- Th-Pb analysis, suggests a source in the post-tectonic syenites of northern Taymyr and nearby islands in the Kara Sea. Textural trends reported in the literature indicate that the Lower Jurassic nonmarine strata of Franz Josef Land coarsen to the southeast; this suggests the existence of a sedimentary system in which detrital zircons could be transported from the northern Taymyr Peninsula to the outer Barents shelf near the position of core 94-PC27 prior to opening of the Eurasia Basin. Correlation of the coaly siltstone in core 94-PC27 with part of the Mesozoic section on Franz Josef Land is compatible with the strong evidence from seafloor magnetic anomalies and bathymetry that Lomonosov Ridge is a continental fragment rifted from the Barents shelf during the Cenozoic. It also suggests that Lomonosov Ridge near the North Pole is underlain by a substantial section of unmetamorphosed Mesozoic marine and nonmarine sedimentary strata. Core 94-PC29 sampled cyclical deposits containing ice-rafted debris (IRD) overlying weakly consolidated laminated olive-black anoxic Neogene siltstone and mudstone with an average total organic carbon (TOC) of 4.1 wt%. The high TOC content of the mudstone indicates that during the Neogene, prior to the introduction of IRD into the Arctic seas about 3.3 Ma (early late Pliocene), the shallow waters of the central Arctic Ocean supported significant primary photosynthetic organic production near the North Pole. These deposits also contain fine grains of siltstone that resemble the breccia-clast siltstone of core 94-PC27 and reworked Carboniferous, Cretaceous, and Tertiary palynomorphs that may have also originated in the bedrock of Lomonosov Ridge.

Pollen stratigraphy, vegetation and climate history of the last 215 ka in the Azzano Decimo core (plain of Friuli, north-eastern Italy)

NASA Astrophysics Data System (ADS)

Pini, R.; Ravazzi, C.; Donegana, M.

2009-06-01

The pollen record of the long succession of marine and continental deposits filling the subsident north-Adriatic foredeep basin (NE Italy) documents the history of vegetation, the landscape evolution and the climate forcing during the last 215 ka at the south-eastern Alpine foreland. The chronology relies on several 14C determinations as well as on estimated ages of pollen-stratigraphical and sea-level event tie-points derived from comparison with high-resolution marine records, speleothemes and ice cores. Mixed temperate rainforests persisted throughout MIS 7a-7c, being replaced by conifer forests after the local glacioeustatic regression during early MIS 6. The Alpine piedmont facing the Adriatic foredeeep was glaciated at the culmination of the penultimate glaciation, as directly testified by in situ fluvioglacial aggradation related to the building of a large morainic amphitheatre. The pollen record allows correlation with other European records and with the IRD from N-Atlantic and off Iberia, thus the duration of the penultimate glacial culmination at the southalpine fringe is estimated less than 13 ka between 148 ± 1 and >135 ka. The site was not reached by the Last Interglacial maximum sea transgression and enregistered a typical, though incomplete, Eemian forest record, lacking Mediterranean evergreen trees. A complex sequence of stadial-interstadial episodes is reconstructed during the Early and Middle Würm: major xerophyte peaks match IRD maxima occurred during Heinrich events in deep-sea cores offshore Iberia and in the N-Atlantic and allows to frame lumps of interstadial phases, marked by Picea peaks, each one including several DO warm events. Broad-leaved thermophilous forests disappeared from the north-eastern plain of Italy at the end of the Early Würm, whereas reduced populations of Abies and Fagus probably sheltered even during the Last Glacial Maximum. A renewed fluvioglacial in situ deposition between 30.4 ± 0.4 and 21.6 ± 0.5 ka cal BP sets the time and duration of the last glacial culmination in the pedemontane morainic amphitheatre. Palynomorphs from Plio-Pleistocene marine successions were reworked by glacier erosion and deposited in the lowland during both the penultimate and the last deglaciation phases. This explains a bias affecting previous pollen records from the region.

Subsurface warming in the subpolar North Atlantic during rapid climate events in the Early and Mid-Pleistocene

NASA Astrophysics Data System (ADS)

Hernández-Almeida, Iván; Sierro, Francisco; Cacho, Isabel; Abel Flores, José

2014-05-01

A new high-resolution reconstruction of the temperature and salinity of the subsurface waters using paired Mg/Ca-δ18O measurements on the planktonic foraminifera Neogloboquadrina pachyderma sinistrorsa (sin.) was conducted on a deep-sea sediment core in the subpolar North Atlantic (Site U1314). This study aims to reconstruct millennial-scale subsurface hydrography variations during the Early and Mid-Pleistocene (MIS 31-19). These rapid climate events are characterized by abrupt shifts between warm/cold conditions, and ice-sheet oscillations, as evidenced by major ice rafting events recorded in the North Atlantic sediments (Hernández-Almeida et al., 2012), similar to those found during the Last Glacial period (Marcott et al, 2011). The Mg/Ca derived paleotemperature and salinity oscillations prior and during IRD discharges at Site U1314 are related to changes in intermediate circulation. The increases in Mg/Ca paleotemperatures and salinities during the IRD event are preceded by short episodes of cooling and freshening of subsurface waters. The response of the AMOC to this perturbation is an increased of warm and salty water coming from the south, transported to high latitudes in the North Atlantic beneath the thermocline. This process is accompanied by a southward shift in the convection cell from the Nordic Seas to the subpolar North Atlantic and better ventilation of the North Atlantic at mid-depths. Poleward transport of warm and salty subsurface subtropical waters causes intense basal melting and thinning of marine ice-shelves, that culminates in large-scale instability of the ice sheets, retreat of the grounding line and iceberg discharge. The mechanism proposed involves the coupling of the AMOC with ice-sheet dynamics, and would explain the presence of these fluctuations before the establishment of high-amplitude 100-kyr glacial cycles. Hernández-Almeida, I., Sierro, F.J., Cacho, I., Flores, J.A., 2012. Impact of suborbital climate changes in the North Atlantic on ice sheet dynamics at the Mid-Pleistocene Transition. Paleoceanography 27, PA3214. Marcott, S.A., Clark, P.U., Padman, L., Klinkhammer, G.P., Springer, S.R., Liu, Z., Otto-Bliesner, B.L., Carlson, A.E., Ungerer, A., Padman, J., He, F., Cheng, J., Schmittner, A., 2011. Ice-shelf collapse from subsurface warming as a trigger for Heinrich events. Proceedings of the National Academy of Sciences 108, 13415-13419

Long-Term Changes In The Behaviour Of Jakobshavns Isbrae, West Greenland During The Late Quaternary-Holocene

NASA Astrophysics Data System (ADS)

O'Cofaigh, C.; Jennings, A.; Moros, M.; Andrews, J. T.; Kilfeather, A.; Dowdeswell, J. A.; Richter, T.

2008-12-01

This poster shows the initial results of a joint scientific project to reconstruct the Late Quaternary-Holocene behavior of Jakobshavns Isbrae in central west Greenland, one of the largest ice streams draining the modern Greenland Ice Sheet. The underlying rationale for this research is to determine if recent observed changes to the mass balance of the Greenland Ice Sheet are part of the natural variability in ice-sheet dynamics, or if they relate to anthropogenically-induced climate warming. Key to resolving this question is an understanding of long-term changes in ice sheet behavior during the Late Quaternary and the Holocene. This research will allow assessment of the links between deglaciation and internal and external environmental controls, such as the influence of inflowing Atlantic Water, and will facilitate modelling of the likely future behavior of the GIS. Currently, four marine sediment cores arrayed along a transect from the Disko Bugt Fan to Disko Bay are providing information on changes in sediment flux and sedimentation style, such as abrupt intervals of iceberg-rafting vs. "normal" hemipelagic sedimentation, as well as the paleoceanographic setting and ice sheet-ocean interactions. The cores are being analysed using a variety of proxies including IRD, mineralogy, oxygen isotopes, foraminiferal assemblages, lithofacies analysis and AMS radiocarbon dating. Data are presented from two piston cores from the continental slope at the trough-mouth fan collected during the HE0006 'shakedown' cruise to Baffin Bay and from two gravity cores recovered in 2007 during MS Merian cruise MSM 05/03 to West Greenland. Slope cores contain sequences of laminated facies interpreted as fine-grained turbidites and intervals of massive, bioturbated, hemipelagic mud. The two Merian cores, contributed to this project by the Baltic Sea Research Institute, were collected from the southern entrance to Disko Bugt and the Vaigat channel north of Disko. Radiocarbon dates from the Disko Bugt core show that it contains a full Holocene record of glacial activity and paleoceanography. The poster will present the initial analyses, including radiocarbon dating, XRF compositional data, magnetic susceptibility, lithofacies and IRD analyses determined from x-radiography, foraminiferal analyses and sediment mineralogy. Additional cores and seismic data for this project will be obtained from a cruise on the Canadian research vessel, CSS Hudson in September 2008, and on the British ship, the RRS James Clark Ross in 2009.

Ice-Sheet Dynamics and Millennial-Scale Climate Variability in the North Atlantic across the Middle Pleistocene Transition (Invited)

NASA Astrophysics Data System (ADS)

Hodell, D. A.; Nicholl, J.

2013-12-01

During the Middle Pleistocene Transition (MPT), the climate system evolved from a more linear response to insolation forcing in the '41-kyr world' to one that was decidedly non-linear in the '100-kyr world'. Smaller ice sheets in the early Pleistocene gave way to larger ice sheets in the late Pleistocene with an accompanying change in ice sheet dynamics. We studied Sites U1308 (49° 52.7'N, 24° 14.3'W; 3871 m) and U1304 (53° 3.4'N, 33° 31.8'W; 3024 m) in the North Atlantic to determine how ice sheet dynamics and millennial-scale climate variability evolved as glacial boundary conditions changed across the MPT. The frequency of ice-rafted detritus (IRD) in the North Atlantic was greater during glacial stages prior to 650 ka (MIS 16), reflecting more frequent crossing of an ice volume threshold when the climate system spent more time in the 'intermediate ice volume' window, resulting in persistent millennial scale variability. The rarity of Heinrich Events containing detrital carbonate and more frequent occurrence of IRD events prior to 650 ka may indicate the presence of 'low-slung, slippery ice sheets' that flowed more readily than their post-MPT counterparts (Bailey et al., 2010). Ice volume surpassed a critical threshold across the MPT that permitted ice sheets to survive boreal summer insolation maxima, thereby increasing ice volume and thickness, lengthening glacial cycles, and activating the dynamical processes responsible for Laurentide Ice Sheet instability in the region of Hudson Strait (i.e., Heinrich events). The excess ice volume during post-MPT glacial maxima provided a large, unstable reservoir of freshwater to be released to the North Atlantic during glacial terminations with the potential to perturb Atlantic Meridional Overtunring Circulation. We speculate that orbital- and millennial-scale variability co-evolved across the MPT and the interaction of processes on orbital and suborbital time scales gave rise to the changing patterns of glacial-interglacial cycles through the Quaternary. Bailey, I., Bolton, C.T., DeConto, R.M., Pollard, D., Schiebel, R. and Wilson, P.A. (2010) A low threshold for North Atlantic ice rafting from "low-slung slippery" late Pliocene ice sheets. Paleoceanography, 25, PA1212-[14pp]. (doi:10.1029/2009PA001736).

Weathering During Glacial-Interglacial Cycles Based on Pb Isotopes at Orphan Knoll, NW Atlantic

NASA Astrophysics Data System (ADS)

Flynn, S. N.; Martin, E. E.

2017-12-01

Seawater Pb isotopes extracted from FeMn oxyhydroxide coatings on deep sea sediments preserve a record of regional variations in continental weathering intensity. Crocket et al. (2012) documented a distinct increase in seawater Pb isotopes across Termination I (TI) at IODP Sites U1302/03 on Orphan Knoll in the NW Atlantic which they attributed to an increase in weathering intensity associated with ice sheet retreat. Deglaciation during Termination II (TII) was more rapid than TI due to higher insolation forcing and elevated CO2 levels. This rapid warming followed Heinrich Stadial 11 (HS11) cooling and circulation changes, but was not interrupted by a Younger Dryas-type reversal in warming. In this study, Pb isotopic data from leachates of the <63 µm fraction of bulk sediment from TII at Sites U1302/03 are used to test whether changes in weathering are a feature of terminations and whether differences in the character of the termination translate to differences in the weathering response. We analyzed the clay/silt fraction to minimize preformed FeMn oxyhydroxides associated with IRD. All three Pb isotopic systems display similar patterns. Seawater 206Pb/204Pb values are 19.5 during MIS 6, reach a minimum of 18.7 during HS11, increase in < 1 ky to 20.6 in MIS 5e, and then vary between 19.9 - 20.5 across MIS 5e-d. In comparison to the TI study (Crocket et al., 2009), the TII HS is defined by a minimum in Pb isotopes that suggests suppressed chemical weathering during cooling and ice sheet advance. The increase in 206Pb/204Pb during TII indicates a rapid increase in weathering at high latitudes following glacial retreat. This result is consistent with a negative shift in ɛNd values during TII observed farther south on Bermuda Rise and interpreted as increased weathering of old continental material (Deaney et al. 2017). Future research on TII at Orphan Knoll includes analyses of detrital Pb isotopes to isolate the impact of changes in source material versus weathering intensity on seawater Pb isotopes, and analyses of seawater Nd isotopes to better understand how changes in circulation might impact delivery of silt/clay fractions to Orphan Knoll. Overall, trends in seawater Pb isotopes at TII illustrate that variations in weathering intensity are sensitive to the rate and magnitude of climate change.

Volatile organic compounds up to C 20 emitted from motor vehicles; measurement methods

NASA Astrophysics Data System (ADS)

Zielinska, Barbara; Sagebiel, John C.; Harshfield, Gregory; Gertler, Alan W.; Pierson, William R.

To understand better the sources of observed differences between on-road vehicle emissions and model estimates, and to evaluate the emission of ozone precursors from motor vehicles, a series of experiments was conducted in the Fort McHenry Tunnel, Baltimore, Maryland (18-24 June 1992), and in the Tuscarora Mountain Tunnel, Pennsylvania (2-8 September 1992). Samples were collected using stainless steel canisters (whole air samples, analyzed for C 2C 12 hydrocarbons), Tenax-TA solid adsorbent cartridges (for semi-volatile hydrocarbons, in the C 8C 20 range), and 2,4-dinitrophenylhydrazine (DNPH) impregnated cartridges (for carbonyl compounds). The samples were analyzed using high resolution gas chromatographic separation with Fourier transform infrared/mass spectrometric detection (GC/IRD/ MSD) for qualitative identification and with flame ionization detection (GC/FID) for quantitation of hydrocarbons, and high performance liquid chromatography (HPLC) for identification and quantitation of carbonyl compounds. A custom-designed database management system was used to handle the large data sets generated by these analyses. From the evaluation of canister and Tenax sample stability upon storage, it was found that hydrocarbons in the C 8C 12 range seemed to be more stable in the Tenax cartridge than in the canister. The effect of the Nafion® dryer (frequently used for moisture removal prior to cryogenic concentration of the canister samples) was also assessed and it was found to lower the measured concentrations of hydrocarbons collected in the canisters. Comparison of hydrocarbon concentrations found in the Tenax and canister samples allows an assessment of the contribution of semi-volatile hydrocarbons (C 10C 20 range derived from Tenax data) to the total non-methane hydrocarbons (C 2C 20, derived from canisters and Tenax data). The results of this study show that hydrocarbons in the range of C 10C 20 are important components of gas-phase hydrocarbons emitted from heavy-duty diesel vehicles (they account for approximately half of the total gas-phase non-methane hydrocarbon emission rates) and hence that solid adsorbent sampling should be used in addition to canister sampling in measurements of motor vehicle emissions.

Full-Scale Incineration System Demonstration Verification Test Burns at the Naval Battalion Construction Center, Gulfport, Mississippi. Volume 3. Treatability Tests. Part 4

DTIC Science & Technology

1991-07-01

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[Revival after Ebola: multidisciplinary assessment at 1 year, prospect and follow-up study of surviving patients from Ebola in Guinea (PostEboGui cohort)].

PubMed

Msellati, P; Touré, A; Sow, M S; Cécé, K; Taverne, B; Desclaux, A; Barry, M; Etard, J-F; Delaporte, E

2016-10-01

Ebola virus disease (EVD) epidemic that spread in West Africa from the end of 2013 to early 2016 has reached more people than all past epidemics. Beyond care management of acute phase ill patients and measures for the control of the epidemic, the outcome of Ebola survivors became an important question as their number increased and raised new issues. A multidisciplinary prospective cohort of survivors in Guinea has been launched by IRD UMI 233 and Donka National Hospital, Conakry, Guinea, to assess the long-term clinical, psychological, sociological, immunological, and viral outcomes potentially related to EVD. This paper describes PostEboGui Programme, constraints and changes to the initial proposal, participants, first results, and new issues, 1 year after its start, in a descriptive and critical view. We started also to work on ethical aspects in the context of epidemics and of mass interventions with a risk of overinvestigation of patients.

Modeling of Steady-state Scenarios for the Fusion Nuclear Science Facility, Advanced Tokamak Approach

NASA Astrophysics Data System (ADS)

Garofalo, A. M.; Chan, V. S.; Prater, R.; Smith, S. P.; St. John, H. E.; Meneghini, O.

2013-10-01

A Fusion National Science Facility (FNSF) would complement ITER in addressing the community identified science and technology gaps to a commercially attractive DEMO, including breeding tritium and completing the fuel cycle, qualifying nuclear materials for high fluence, developing suitable materials for the plasma-boundary interface, and demonstrating power extraction. Steady-state plasma operation is highly desirable to address the requirements for fusion nuclear technology testing [1]. The Advanced Tokamak (AT) is a strong candidate for an FNSF as a consequence of its mature physics base, capability to address the key issues with a more compact device, and the direct relevance to an attractive target power plant. Key features of AT are fully noninductive current drive, strong plasma cross section shaping, internal profiles consistent with high bootstrap fraction, and operation at high beta, typically above the free boundary limit, βN > 3 . Work supported by GA IR&D funding, DE-FC02-04ER54698, and DE-FG02-95ER43309.

[Leaf nitrogen and phosphorus stoichiometry of shrubland plants in the rocky desertification area of Southwestern Hunan, China.

PubMed

Jing, Yi Ran; Deng, Xiang Wen; Wei, Hui; Li, Yan Qiong; Deng, Dong Hua; Liu, Hao Jian; Xiang, Wen Hua

2017-02-01

In this paper, we took the leaves of shrubland plants in rocky desertification area in Southwestern Hunan as the research object to analyze the nitrogen (N) and phosphorus (P) stoichiometry characteristics for different functional groups and different grades of rocky desertification, i.e., light rocky desertification (LRD), moderate rocky desertification (MRD) and intense rocky desertification (IRD). The results showed that the average contents of N and P were 12.89 and 1.19 g·kg -1 , respectively, and N/P was 11.24 in common shrubland plants in the study area, which indicated that the growth of most plants were mainly limited by N. The content of N was declined in order of deciduous shrubs > evergreen shrubs > annual herbs > perennial herbs. The content of P and N/P were higher in deciduous shrubs than in perennial herbs. Significant differences were found among the main families of plants in terms of the contents of N, P and N/P in the study sites. The plants of Gramineae had the lowest contents of N and P, andtheir growth was mostly restricted by N, while Leguminosae had the highest content of N and N/P, and their productivity was majorly controlled by P. The contents of N and P in the leaves were significantly higher in dicotyledon plants and C3 plants than in monocotyledon plants and C4 plants, but the N/P was not significantly diffe-rent between these two plant categories. The nitrogen-fixing plants had higher content of N and N/P than the non-nitrogen-fixing plants, but the P content was not significantly different between these two plant groups. There were significant correlations between contents of N and P, N/P and N in all study plots. No significant correlation was found between N/P and P content in the examined rocky desertification sites, except for that in MRD. There were no significant differences of the contents of N, P and N/P under different grades of rocky desertification.

Late Quaternary Productivity Records from Coccolith Sr/Ca

NASA Astrophysics Data System (ADS)

Stoll, H. M.; Burke, A.; Mejia Ramirez, L. M.; Shimizu, N.; Ziveri, P. P. I.

2014-12-01

The Sr/Ca of coccoliths has been proposed as an indicator of productivity on the basis of correlation with export production in sediment traps and across upwelling productivity gradients, although the mechanism responsable for this relationship is not clear. For diverse oceanographic settings in the Late Quaternary, we compare coccolith Sr/Ca productivity records with those of other productivity indicators and proxies for mechanisms of productivity forcing. For the Somalia Basin in the Arabian Sea, coccolith Sr/Ca shows a large variation coherent with precessional forcing of wind strength as a mechanism for productivity regulation. During the glacial, the Sr/Ca peak is decoupled from productivity indicators based on organic C accumulation rate. For the Northern Bay of Bengal, coccolith Sr/Ca, Ba/Ti, and relative abundance of G. bulloides, all suggest greater productivity during the interglacial periods, consisted with Nd isotopic evidence for greater riverine nutrient inputs. In the Andaman Sea, coccolith Sr/Ca is highest during precessional maxima in the summer monsoon, consistent with proxies for chemical weathering in the Irawaddy rivershed. In the Eastern Mediterranean, coccolith Sr/Ca is on average low, and peaks during the E. Holocene interval characterized by deposition of sapropel S1. The peak in Sr/Ca however is comparable to the level maintained throughout the Holocene in the Western Mediterranean, where no sapropel occurs, implicating deepwater oxygen levels as a significant contributor to sapropel formation. Finally, on the Agulhas Bank, minima in coccolith Sr/Ca occur during obliquity minima which are periods of anomalous equatorward deposition of IRD in the Southern Ocean. Northward explansion of the westerly wind field during these cold intervals, block upwelling on the Agulhas Bank and result in low productivity.

Comparison of different drying methods on the physical properties, bioactive compounds and antioxidant activity of raspberry powders.

PubMed

Si, Xu; Chen, Qinqin; Bi, Jinfeng; Wu, Xinye; Yi, Jianyong; Zhou, Linyan; Li, Zhaolu

2016-04-01

Dehydration has been considered as one of the traditional but most effective techniques for perishable fruits. Raspberry powders obtained after dehydration can be added as ingredients into food formulations such as bakery and dairy products. In this study, raspberry powders obtained by hot air drying (HAD), infrared radiation drying (IRD), hot air and explosion puffing drying (HA-EPD), infrared radiation and microwave vacuum drying (IR-MVD) and freeze drying (FD) were compared on physical properties, bioactive compounds and antioxidant activity. Drying techniques affected the physical properties, bioactive compounds and antioxidant activity of raspberry powders greatly. FD led to significantly higher (P < 0.05) values of water solubility (45.26%), soluble solid (63.46%), hygroscopicity (18.06%), color parameters and anthocyanin retention (60.70%) of raspberry powder compared with other drying methods. However, thermal drying techniques, especially combined drying methods, were superior to FD in final total polyphenol content, total flavonoid content and antioxidant activity. The combined drying methods, especially IR-MVD, showed the highest total polyphenol content (123.22 g GAE kg(-1) dw) and total flavonoid content (0.30 g CAE kg(-1) dw). Additionally, IR-MVD performed better in antioxidant activity retention. Overall, combined drying methods, especially IR-MVD, were found to result in better quality of raspberry powders among the thermal drying techniques. IR-MVD could be recommended for use in the drying industry because of its advantages in time saving and nutrient retention. © 2015 Society of Chemical Industry.

Antarctic link with East Asian summer monsoon variability during the Heinrich Stadial-Bølling interstadial transition

NASA Astrophysics Data System (ADS)

Zhang, Hongbin; Griffiths, Michael L.; Huang, Junhua; Cai, Yanjun; Wang, Canfa; Zhang, Fan; Cheng, Hai; Ning, Youfeng; Hu, Chaoyong; Xie, Shucheng

2016-11-01

Previous research has shown a strong persistence for direct teleconnections between the East Asian summer monsoon (EASM) and high northern latitude climate variability during the last glacial and deglaciation, in particular between monsoon weakening and a reduced Atlantic meridional overturning circulation (AMOC). However, less attention has been paid to EASM strengthening as the AMOC was reinvigorated following peak Northern Hemisphere (NH) cooling. Moreover, climate model simulations have suggested a strong role for Antarctic meltwater discharge in modulating northward heat transport and hence NH warming, yet the degree to which Southern Hemisphere (SH) climate anomalies impacted the Asian monsoon region is still unclear. Here we present a new stalagmite oxygen-isotope record from the EASM affected region of central China, which documents two prominent stages of increased 18O-depleted moisture delivery to the region through the transition from Heinrich Stadial 1 (HS1) to the Bølling-Allerød (B-A) interstadial; this is in general agreement with the other monsoonal records from both NH and SH mid to low latitudes. Through novel comparisons with a recent iceberg-rafted debris (IRD) record from the Southern Ocean, we propose that the two-stage EASM intensification observed in our speleothem records were linked with two massive Antarctic icesheet discharge (AID) events at ∼16.0 ka and ∼14.7 ka, immediately following the peak HS1 stadial event. Notably, the large increase in EASM intensity at the beginning of the HS1/B-A transition (∼16 ka) is relatively muted in the NH higher latitudes, and better aligns with the changes observed in the SH, indicating the Antarctic and Southern Ocean perturbations could have an active role in driving the initial EASM strengthening at this time. Indeed, Antarctic freshwater input to the Southern Ocean during these AID events would have cooled the surrounding surface waters and caused an expansion of sea ice, restricting the southern extent of the SH westerlies. Moreover, increased meltwater flux during IRD events would have freshened Antarctic Intermediate Water, leading to the increased formation of North Atlantic Deep Water and enhanced North Atlantic subsurface heat release, and causing a strengthening of the AMOC during the HS1-Bølling transition. The result of this sequence-of-events would have been warming in the North Atlantic whilst at the same time cooling in the Antarctic. The ensuing interhemispheric temperature gradient would have acted to push the ITCZ northward, weakening the Australian-Indonesian summer monsoon (AISM) whilst intensifying the EASM.

Timing of Glacial Lake Missoula Outburst Floods and the southwestern Cordilleran Ice Sheet retreat.

NASA Astrophysics Data System (ADS)

Hendy, I. L.; Bervid, H. D.; Carlson, A. E.

2017-12-01

Glacial Lake Missoula formed when the Purcell Trench Lobe dammed the Clark Fork River in Montana and catastrophically collapsed repeatedly through the last glacial period as the southern Cordilleran Ice Sheet advanced and retreated. A well-dated 50-kyr jumbo piston core MD02-2496 (48.97˚ N, 127.04˚ W, water depth of 1243 m) collected from the continental slope 75 km off Vancouver Island contains evidence of these floods. The in-situ bulk elemental composition of the 35-m core was determined at 1 mm intervals using an ITRAX X-ray Fluorescence (XRF) Core Scanner (Cox Analytical Instruments) at the Sediment Geochemistry Lab of the College of Earth, Ocean, and Atmospheric Sciences at Oregon State University. With 40 mixed planktonic foraminifera and bulk organic carbon 14C ages, the core provides a high-resolution resolution record of glaciomarine sedimentation during deglaciation. A series of >81 layers of fine-grained sediments with ancient (K/Ar ages of 300 Ma and eNd of -8) shale-like (high Rb counts) composition can be found between 19.6 and 9.2 m below coretop. These layers are interspersed by coarser grained, young (K/Ar ages of 100 Ma and eNd of -3) sediments containing ice-rafted debris (IRD). The composition and age of the layers indicates the sediments originated in Glacial Lake Missoula and were transported by ocean currents 250 miles north along the west coast of North America. The flood layers begin at 19.5 ka with five thin (<5 cm thick) layers before thick flood layers (>5 cm thick) appear after 19.3 ka. At 17.1 ka, IRD concentrations increase from <1 grain g-1 to 20 grains g-1, and remain >50 grains g-1 from 16.5-16.35 ka, except in flood layers, as the Juan de Fuca Strait deglaciated. Another 16 flood layers occur from 16.3-15.65 ka; however, the base and top of these layers are diffuse rather than abrupt like earlier flood layers suggesting enhanced mixing between flood and melt waters. The final flood layers from 14.9-14.5 ka are thin (<2 cm thick) suggesting that the final floods were small events similar to the initial floods. This well-dated sequence displays how Glacial Lake Missoula flood sedimentation changed during the advance and retreat of the Cordilleran Ice Sheet.

Field applications of ion-mobility spectrometry

NASA Astrophysics Data System (ADS)

Brown, Patricia A.

1997-02-01

Ion mobility spectrometry (IMS) is an excellent tool for detection of controlled substances under field conditions. Plasmagrams and tables showing the results of field applications will be discussed. Residues of drugs, such as cocaine and heroin, can be left anywhere including vehicles, boats, and houses. In houses, the carpets, walls, and floors are good locations for residues to adhere. Individual clothing can also be contaminated with drug residue. Vehicles that are suspected of having previously smuggled illegal substances can be vacuumed and screened. Tablets that look similar and respond the same when screened with the Marquis reagent can be differentiated by IMS. With Southern California being the 'methamphetamine capital of the world' and the resurgence of phencyclidine, IMS has proven extremely valuable in the screening of abandoned clandestine laboratory sites and vehicles in which the clandestine laboratories; chemicals and glassware were transported. IMS is very responsive to ephedrine/pseudophedrine, a precursor of methamphetamine and 1-piperidinocyclohexanecarbonitrile, an intermediate of phencyclidine. Once residues are detected, vacuum samples, and/or methanol wipes are collected and analyzed at the DEA Laboratory for confirmation of the suspected substance using GC-IRD or Mass Spectrometry.

M-X Environmental Technical Report. Socioeconomic Impact Estimates for Millard County, Utah. Detailed Tables.

DTIC Science & Technology

1980-12-22

rv a N NOm r 0. I N e V. 0 o’lN N’) Nvci 4 10 d DNV ’C N M’ CL1 NON .1 N C ’i C’ N’C a,(’N 090 MOO .(~0 ~ N Ird 0 V 0 -14 v 0 .0 m 0 N 4M N I C- lt V W...73 , 043 0 43 4 43 7 - o 0 03 4 z. 4C 3 4) 33 04- - . 7- 7 4 0 77 Q3 00 3E0 -~ I I’ ’ ’iwL a. -. - .4 4. I- L, 2.7 Uz; .3 z 7 2 Zj C) Ia 4 - I .. C I...u 0 mCulu 0 Cun 0 ,u’ m 0 Il -’D Cu N. Cu 0. C- C’ rv 0 .N u m. Cu r.0 M )0. 0 L W Io (n - -’Cuu ( VM -J -. I m -Im I 0 NO t ND 0..00 0 NOM 0 m n O 0

ChIP-Chip Identifies SEC23A, CFDP1, and NSD1 as TFII-I Target Genes in Human Neural Crest Progenitor Cells.

PubMed

Makeyev, Aleksandr V; Bayarsaihan, Dashzeveg

2013-05-01

Objectives :  GTF2I and GTF2IRD1 genes located in Williams-Beuren syndrome (WBS) critical region encode TFII-I family transcription factors. The aim of this study was to map genomic sites bound by these proteins across promoter regions of developmental regulators associated with craniofacial development. Design :  Chromatin was isolated from human neural crest progenitor cells and the DNA-binding profile was generated using the human RefSeq tiling promoter ChIP-chip arrays. Results :  TFII-I transcription factors are recruited to the promoters of SEC23A, CFDP1, and NSD1 previously defined as TFII-I target genes. Moreover, our analysis revealed additional binding elements that contain E-boxes and initiator-like motifs. Conclusions :  Genome-wide promoter binding studies revealed SEC23A, CFDP1, and NSD1 linked to craniofacial or dental development as direct TFII-I targets. Developmental regulation of these genes by TFII-I factors could contribute to the WBS-specific facial dysmorphism.

Molecular basis of Williams-Beuren syndrome: TFII-I regulated targets involved in craniofacial development.

PubMed

Makeyev, Aleksandr V; Bayarsaihan, Dashzeveg

2011-01-01

The aim of this study is to identify gene targets of TFII-I transcription factors involved in craniofacial development. Recent findings in individuals with Williams-Beuren syndrome who show facial dysmorphism and cognitive defects have pointed to TFII-I genes (GTF2I and GTF2IRD1) as the prime candidates responsible for these clinical features. However, TFII-I proteins are multifunctional transcriptional factors regulating a number of genes during development, and how their haploinsufficiency leads to the Williams-Beuren syndrome phenotype is currently unknown. Here we report the identification of three genes with a well-established relevance to craniofacial development as direct TFII-I targets. These genes, craniofacial development protein 1 (Cfdp1), Sec23 homolog A (Sec23a), and nuclear receptor binding SET domain protein 1 (Nsd1), contain consensus TFII-I binding sites in their proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo. The results suggest that transcriptional regulation of these genes by TFII-I proteins could provide a possible genotype-phenotype link in Williams-Beuren syndrome.

Synchronicity of the East Asian Summer Monsoon variability and Northern Hemisphere climate change since the last deglaciation

NASA Astrophysics Data System (ADS)

Shinozaki, T.; Uchida, M.; Minoura, K.; Kondo, M.; Rella, S. F.; Shibata, Y.

2011-06-01

Understanding of the mechanism of the East Asian Summer Monsoon (EASM) is required for the prediction of climate change in East Asia in a scenario of modern global warming. In this study, we present high-resolution climate records from peat sediments in Northeast Japan to reconstruct the EASM variability based on peat bulk cellulose δ13C since the last deglaciation. We used a 8.8 m long peat sediment core collected from the Tashiro Bog, Northeast Japan. Based on 42 14C measurements, the core bottom reaches ~15.5 ka. δ13C, accumulation rate and accumulation flux time-series correlate well to Greenland ice core δ18O variability, suggesting that the climate record in Northeast Japan is linked to global climate changes. The δ13C record at Tashiro Bog and other paleo-EASM records at Northeast and Southern China consistently demonstrate that hydrological environments were spatially different in mid-high and mid-low latitude regions over the last 15.5 kyr. During global cooling (warming) periods, mid-high and mid-low latitude regions were characterized by wet (dry) and dry (wet) environments, respectively. We suggest that these climatic patterns are related to the migration of the EASM-related rain belt during global climate changes, as a consequence of variations in intensity and location of both the Intertropical Convergence Zone (ITCZ) and the Western Pacific Subtropical High (STH). The location of the rain belt largely influences the East Asian hydrological environment. Our δ13C time-series are characterized by a 1230 yr throughout the Holocene and a 680 yr periodicity during the early Holocene. The 1230 yr periodicity is in agreement with North Atlantic ice-rafted debris (IRD) events, suggesting a teleconnection between the Northeast Japan and the North Atlantic during the Holocene. In addition, it is the first evidence that the Bond events were recorded in terrestrial sediment in Japan. On the other hand, the 680 yr periodicity between 10.0 and 8.0 kyr is consistent with a prominent 649 yr solar activity cycle, suggesting that solar activity affected EASM precipitation during the Hypsithermal, when orbital-scale solar insolation was at a maximum in the Northern Hemisphere.

Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management

PubMed Central

2012-01-01

Background The Influenza A H1N1 virus can be transmitted via direct, indirect, and airborne route to non-infected subjects when an infected patient coughs, which expels a number of different sized droplets to the surrounding environment as an aerosol. The objective of the current study was to characterize the human cough aerosol pattern with the aim of developing a standard human cough bioaerosol model for Influenza Pandemic control. Method 45 healthy non-smokers participated in the open bench study by giving their best effort cough. A laser diffraction system was used to obtain accurate, time-dependent, quantitative measurements of the size and number of droplets expelled by the cough aerosol. Results Voluntary coughs generated droplets ranging from 0.1 - 900 microns in size. Droplets of less than one-micron size represent 97% of the total number of measured droplets contained in the cough aerosol. Age, sex, weight, height and corporal mass have no statistically significant effect on the aerosol composition in terms of size and number of droplets. Conclusions We have developed a standard human cough aerosol model. We have quantitatively characterized the pattern, size, and number of droplets present in the most important mode of person-to-person transmission of IRD: the cough bioaerosol. Small size droplets (< 1 μm) predominated the total number of droplets expelled when coughing. The cough aerosol is the single source of direct, indirect and/or airborne transmission of respiratory infections like the Influenza A H1N1 virus. Study design Open bench, Observational, Cough, Aerosol study PMID:22436202

Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management.

PubMed

Zayas, Gustavo; Chiang, Ming C; Wong, Eric; MacDonald, Fred; Lange, Carlos F; Senthilselvan, Ambikaipakan; King, Malcolm

2012-03-21

The Influenza A H1N1 virus can be transmitted via direct, indirect, and airborne route to non-infected subjects when an infected patient coughs, which expels a number of different sized droplets to the surrounding environment as an aerosol. The objective of the current study was to characterize the human cough aerosol pattern with the aim of developing a standard human cough bioaerosol model for Influenza Pandemic control. 45 healthy non-smokers participated in the open bench study by giving their best effort cough. A laser diffraction system was used to obtain accurate, time-dependent, quantitative measurements of the size and number of droplets expelled by the cough aerosol. Voluntary coughs generated droplets ranging from 0.1 - 900 microns in size. Droplets of less than one-micron size represent 97% of the total number of measured droplets contained in the cough aerosol. Age, sex, weight, height and corporal mass have no statistically significant effect on the aerosol composition in terms of size and number of droplets. We have developed a standard human cough aerosol model. We have quantitatively characterized the pattern, size, and number of droplets present in the most important mode of person-to-person transmission of IRD: the cough bioaerosol. Small size droplets (< 1 μm) predominated the total number of droplets expelled when coughing. The cough aerosol is the single source of direct, indirect and/or airborne transmission of respiratory infections like the Influenza A H1N1 virus. Open bench, Observational, Cough, Aerosol study. © 2012 Zayas et al; licensee BioMed Central Ltd.

Variations in Mediterranean-Atlantic exchange across the late Pliocene climate transition

NASA Astrophysics Data System (ADS)

García-Gallardo, Ángela; Grunert, Patrick; Piller, Werner E.

2018-03-01

Mediterranean-Atlantic exchange through the Strait of Gibraltar plays a significant role in the global ocean-climate dynamics in two ways. On one side, the injection of the saline and warm Mediterranean Outflow Water (MOW) contributes to North Atlantic deep-water formation. In return, the Atlantic inflow is considered a sink of less saline water for the North Atlantic Ocean. However, while the history of MOW is the focus of numerous studies, the Pliocene Atlantic inflow has received little attention so far. The present study provides an assessment of the Mediterranean-Atlantic exchange with a focus on the Atlantic inflow strength and its response to regional and global climate from 3.33 to 2.60 Ma. This time interval comprises the mid-Pliocene warm period (MPWP; 3.29-2.97 Ma) and the onset of the Northern Hemisphere glaciation (NHG). For this purpose, gradients in surface δ18O records of the planktonic foraminifer Globigerinoides ruber between the Integrated Ocean Drilling Program (IODP) Hole U1389E (Gulf of Cádiz) and Ocean Drilling Program (ODP) Hole 978A (Alboran Sea) have been evaluated. Interglacial stages and warm glacials of the MPWP revealed steep and reversed (relative to the present) W-E δ18O gradients suggesting a weakening of Mediterranean-Atlantic exchange likely caused by high levels of relative humidity in the Mediterranean region. In contrast, periods of stronger inflow are indicated by flat δ18O gradients due to more intense arid conditions during the severe glacial Marine Isotope Stage (MIS) M2 and the initiation of NHG (MIS G22, G14, G6-104). Intensified Mediterranean-Atlantic exchange in cold periods is linked to the occurrence of ice-rafted debris (IRD) at low latitudes and a weakening of the Atlantic Meridional Overturning Circulation (AMOC). Our results thus suggest the development of a negative feedback between AMOC and exchange rates at the Strait of Gibraltar in the latest Pliocene as it has been proposed for the late Quaternary.

QueTAL: a suite of tools to classify and compare TAL effectors functionally and phylogenetically

PubMed Central

Pérez-Quintero, Alvaro L.; Lamy, Léo; Gordon, Jonathan L.; Escalon, Aline; Cunnac, Sébastien; Szurek, Boris; Gagnevin, Lionel

2015-01-01

Transcription Activator-Like (TAL) effectors from Xanthomonas plant pathogenic bacteria can bind to the promoter region of plant genes and induce their expression. DNA-binding specificity is governed by a central domain made of nearly identical repeats, each determining the recognition of one base pair via two amino acid residues (a.k.a. Repeat Variable Di-residue, or RVD). Knowing how TAL effectors differ from each other within and between strains would be useful to infer functional and evolutionary relationships, but their repetitive nature precludes reliable use of traditional alignment methods. The suite QueTAL was therefore developed to offer tailored tools for comparison of TAL effector genes. The program DisTAL considers each repeat as a unit, transforms a TAL effector sequence into a sequence of coded repeats and makes pair-wise alignments between these coded sequences to construct trees. The program FuncTAL is aimed at finding TAL effectors with similar DNA-binding capabilities. It calculates correlations between position weight matrices of potential target DNA sequence predicted from the RVD sequence, and builds trees based on these correlations. The programs accurately represented phylogenetic and functional relationships between TAL effectors using either simulated or literature-curated data. When using the programs on a large set of TAL effector sequences, the DisTAL tree largely reflected the expected species phylogeny. In contrast, FuncTAL showed that TAL effectors with similar binding capabilities can be found between phylogenetically distant taxa. This suite will help users to rapidly analyse any TAL effector genes of interest and compare them to other available TAL genes and should improve our understanding of TAL effectors evolution. It is available at http://bioinfo-web.mpl.ird.fr/cgi-bin2/quetal/quetal.cgi. PMID:26284082

Holocene variations in mineral and grain-size composition along the East Greenland glaciated margin (ca 67°–70°N): local versus long-distance sediment transport

USGS Publications Warehouse

Andrews, John T.; Jennings, Anne E.; Coleman, George C.; Eberl, Dennis D.

2010-01-01

Quantitative X-Ray Diffraction (qXRD) analysis of the <2 mm sediment fraction from surface (sea floor) samples, and marine sediment cores that span the last 10-12 cal ka BP, are used to describe spatial and temporal variations in non-clay mineral compositions for an area between Kangerlussuaq Trough and Scoresby Sund (???67??-70??N), East Greenland. Bedrock consists primarily of an early Tertiary alkaline complex with high weight% of pyroxene and plagioclase. Farther inland and to the north, the bedrock is dominantly felsic with a high fraction of quartz and potassium feldspars. Principal Component (PC) analysis of the non-clay sediment compositions indicates the importance of quartz and pyroxene as compositional end members, with an abrupt shift from quartz and k-feldspar dominated sediments north of Scoresby Sund to sediments rich in pyroxene and plagioclase feldspars offshore from the early Tertiary basaltic outcrop. Coarse (<2 mm or <1 mm) ice-rafted sediments are largely absent from the trough sediments between ???8 and 5 cal ka BP, but then increase in the last 4 cal ka BP. Compositional unmixing of the sediments in Grivel Basin and Kangerlussuaq Trough indicate the dominance of local over long distance sediment sources, with pulses of sediment from tidewater glaciers in Kangerlussuaq and Nansen fjords reaching the inner shelf during the Neoglaciation. The change in IRD is more dramatic in the sediment grain-size proxies than in the quartz wt%. Forty to seventy percent of the variance in the quartz records from either side of Denmark Strait is explained by low frequency trends, but the data from the Grivel Basin, East Greenland, are distinctly different, with an approximate 2500 yr periodicity. ?? 2010 Elsevier Ltd.

Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 8: Appendices HYDRO, IRD, LTM, NUTS, PAR, PMR, QAPD, RBP

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Geohydrologic data have been collected in the Los Medanos area at the US Department of Energy`s proposed Waste Isolation Pilot Plant (WIPP) site in southeastern New Mexico since 1975 as part of a study evaluating the feasibility of storing defense-associated nuclear wastes within the bedded salt of the Salado Formation of Permian age. Drilling and hydrologic testing have identified three principal water-bearing zones above the Salado Formation and one below that could potentially transport wastes to the biosphere if the proposed facility were breached. The zones above the Salado are the contact between the Rustler and Salado Formations and themore » Culebra and Magenta Dolomite Members of the Rustler Formation of Permian age. The zone below the Salado Formation consists of channel sandstones in the Bell Canyon Formation of the Permian Delaware Mountain Group. Determinations of hydraulic gradients, directions of flow, and hydraulic properties were hindered because of the negligible permeability of the water-bearing zones. Special techniques in drilling, well completion, and hydraulic testing have been developed to determine the hydrologic characteristics of these water-producing zones.« less

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

PubMed Central

Sun, Celi; Molineros, Julio E.; Looger, Loren L.; Zhou, Xu-jie; Kim, Kwangwoo; Okada, Yukinori; Ma, Jianyang; Qi, Yuan-yuan; Kim-Howard, Xana; Motghare, Prasenjeet; Bhattarai, Krishna; Adler, Adam; Bang, So-Young; Lee, Hye-Soon; Kim, Tae-Hwan; Kang, Young Mo; Suh, Chang-Hee; Chung, Won Tae; Park, Yong-Beom; Choe, Jung-Yoon; Shim, Seung Cheol; Kochi, Yuta; Suzuki, Akari; Kubo, Michiaki; Sumida, Takayuki; Yamamoto, Kazuhiko; Lee, Shin-Seok; Kim, Young Jin; Han, Bok-Ghee; Dozmorov, Mikhail; Kaufman, Kenneth M.; Wren, Jonathan D.; Harley, John B.; Shen, Nan; Chua, Kek Heng; Zhang, Hong; Bae, Sang-Cheol; Nath, Swapan K.

2016-01-01

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic architecture. We conducted an association study with replication in 4,492 SLE cases and 12,675 controls from six East-Asian cohorts, to identify novel and better localize known SLE susceptibility loci. We identified 10 novel loci as well as 20 known loci with genome-wide significance. Among the novel loci, the most significant was GTF2IRD1-GTF2I at 7q11.23 (rs73366469, Pmeta=3.75×10−117, OR=2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6. We localized the most likely functional variants for each locus by analyzing epigenetic marks and gene regulation data. Ten putative variants are known to alter cis- or trans-gene expression. Enrichment analysis highlights the importance of these loci in B- and T-cell biology. Together with previously known loci, the explained heritability of SLE increases to 24%. Novel loci share functional and ontological characteristics with previously reported loci, and are possible drug targets for SLE therapeutics. PMID:26808113

Clinical and genetic analyses reveal novel pathogenic ABCA4 mutations in Stargardt disease families

PubMed Central

Lin, Bing; Cai, Xue-Bi; Zheng, Zhi-Li; Huang, Xiu-Feng; Liu, Xiao-Ling; Qu, Jia; Jin, Zi-Bing

2016-01-01

Stargardt disease (STGD1) is a juvenile macular degeneration predominantly inherited in an autosomal recessive pattern, characterized by decreased central vision in the first 2 decades of life. The condition has a genetic basis due to mutation in the ABCA4 gene, and arises from the deposition of lipofuscin-like substance in the retinal pigmented epithelium (RPE) with secondary photoreceptor cell death. In this study, we describe the clinical and genetic features of Stargardt patients from four unrelated Chinese cohorts. The targeted exome sequencing (TES) was carried out in four clinically confirmed patients and their family members using a gene panel comprising 164 known causative inherited retinal dystrophy (IRD) genes. Genetic analysis revealed eight ABCA4 mutations in all of the four pedigrees, including six mutations in coding exons and two mutations in adjacent intronic areas. All the affected individuals showed typical manifestations consistent with the disease phenotype. We disclose two novel ABCA4 mutations in Chinese patients with STGD disease, which will expand the existing spectrum of disease-causing variants and will further aid in the future mutation screening and genetic counseling, as well as in the understanding of phenotypic and genotypic correlations. PMID:27739528

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.

PubMed

Sun, Celi; Molineros, Julio E; Looger, Loren L; Zhou, Xu-Jie; Kim, Kwangwoo; Okada, Yukinori; Ma, Jianyang; Qi, Yuan-Yuan; Kim-Howard, Xana; Motghare, Prasenjeet; Bhattarai, Krishna; Adler, Adam; Bang, So-Young; Lee, Hye-Soon; Kim, Tae-Hwan; Kang, Young Mo; Suh, Chang-Hee; Chung, Won Tae; Park, Yong-Beom; Choe, Jung-Yoon; Shim, Seung Cheol; Kochi, Yuta; Suzuki, Akari; Kubo, Michiaki; Sumida, Takayuki; Yamamoto, Kazuhiko; Lee, Shin-Seok; Kim, Young Jin; Han, Bok-Ghee; Dozmorov, Mikhail; Kaufman, Kenneth M; Wren, Jonathan D; Harley, John B; Shen, Nan; Chua, Kek Heng; Zhang, Hong; Bae, Sang-Cheol; Nath, Swapan K

2016-03-01

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 controls from six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci. We identified ten new loci and confirmed 20 known loci with genome-wide significance. Among the new loci, the most significant locus was GTF2IRD1-GTF2I at 7q11.23 (rs73366469, Pmeta = 3.75 × 10(-117), odds ratio (OR) = 2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6. We identified the most likely functional variants at each locus by analyzing epigenetic marks and gene expression data. Ten candidate variants are known to alter gene expression in cis or in trans. Enrichment analysis highlights the importance of these loci in B cell and T cell biology. The new loci, together with previously known loci, increase the explained heritability of SLE to 24%. The new loci share functional and ontological characteristics with previously reported loci and are possible drug targets for SLE therapeutics.

Optimization of (131)I doses for the treatment of hyperthyroidism.

PubMed

Araujo, F; Rebelo, A M O; Pereira, A C; Moura, M B; Lucena, E A; Dantas, A L A; Dantas, B M; Corbo, R

2009-11-15

Several methods can be used to determine the activity of (131)I in the treatment of hyperthyroidism. However, many of them do not consider all the parameters necessary for optimum dose calculation. The relationship between the dose absorbed by the thyroid and the activity administered depends basically on three parameters: organ mass, iodine uptake and effective half-life of iodine in the thyroid. Such parameters should be individually determined for each patient in order to optimize the administered activity. The objective of this work is to develop a methodology for individualized treatment with (131)I in patients with hyperthyroidism of the Grave's Disease. A neck-thyroid phantom developed at the IRD was used to calibrate a scintillation camera and a uptake probe SCT-13004 at the Nuclear Medicine Center of the University Hospital of Rio de Janeiro and a uptake probe SCT-13002, available at the Nuclear Medicine Institute in Goiânia. The biokinetic parameters were determined based on measurements performed in eight voluntary patients. It is concluded that the use of the equipment available at the hospital (scintillation camera and uptake probe) has shown to be a suitable and feasible procedure for dose optimization in terms of effectiveness, simplicity and cost.

Feasibility evaluation of the monolithic braided ablative nozzle

NASA Astrophysics Data System (ADS)

Director, Mark N.; McPherson, Douglass J., Sr.

1992-02-01

The feasibility of the monolithic braided ablative nozzle was evaluated as part of an independent research and development (IR&D) program complementary to the National Aeronautics and Space Administration/Marshall Space Flight Center (NASA/MSFC) Low-Cost, High-Reliability Case, Insulation and Nozzle for Large Solid Rocket Motors (LOCCIN) Program. The monolithic braided ablative nozzle is a new concept that utilizes a continuous, ablative, monolithic flame surface that extends from the nozzle entrance, through the throat, to the exit plane. The flame surface is fabricated using a Through-the-Thickness braided carbon-fiber preform, which is impregnated with a phenolic or phenolic-like resin. During operation, the braided-carbon fiber/resin material ablates, leaving the structural backside at temperatures which are sufficiently low to preclude the need for any additional insulative materials. The monolithic braided nozzle derives its potential for low life cycle cost through the use of automated processing, one-component fabrication, low material scrap, low process scrap, inexpensive raw materials, and simplified case attachment. It also has the potential for high reliability because its construction prevents delamination, has no nozzle bondlines or leak paths along the flame surface, is amenable to simplified analysis, and is readily inspectable. In addition, the braided construction has inherent toughness and is damage-tolerant. Two static-firing tests were conducted using subscale, 1.8 - 2.0-inch throat diameter, hardware. Tests were approximately 15 seconds in duration, using a conventional 18 percent aluminum/ammonium perchlorate propellant. The first of these tests evaluated the braided ablative as an integral backside insulator and exit cone; the second test evaluated the monolithic braided ablative as an integral entrance/throat/exit cone nozzle. Both tests met their objectives. Radial ablation rates at the throat were as predicted, approximately 0.017 in/sec; these rates are comparable to those for tapewrapped carbon phenolic materials. The maximum temperature rise on the outside surface occurred one inch from the nozzle exit plane and was less than 50 F at the end of the test. Further development for this concept is scheduled as part of phase 2 on the NASA/MSFC LOCCIN Program. During this effort, the nozzle materials, architecture, and processing will be optimized and tested in nozzles with 3- and 10-inch diameter throats. Further, a design and manufacturing plan for a full-scale, 20-inch-diameter throat, nozzle will be developed.

Near-Infrared Emission Lines of Nova Cassiopeiae 1995

NASA Astrophysics Data System (ADS)

Rudy, R. J.; Lynch, D. K.; Mazuk, S. M.; Venturini, C. C.; Puetter, R. C.

2000-12-01

The slow nova V 723 Cas (Nova Cas 1995) exhibits comparatively narrow emission features (FWHM 500 km sec-1) that make it ideal for classifying weak lines and lines blended with stronger features. We present spectra from 0.8-2.5 microns that track the gradual incrase in excitation of Nova Cas and discuss the emission lines that were present. During the period encompassed by these observations Nova Cas reached only moderate excitation-the most energetic coronal lines were [S VIII] 9913 and [Al IX] 20444; lines such as [S IX] 12523 that are prominent in some novae were not detected. Additional coronal lines present include [Si VI] 19641, [Ca VIII] 23205, and [Si VII] 24807. New lines identified include features of [Fe V], [Fe VI]. These iron features are not coronal lines, arising from transitions among low-lying terms rather than within the ground term itself. Also detected was [Ti VI] 17151 that was first identified in V1974 Cygni (Nova Cyg 1992), and possibly [Ti VII] 22050. Accurate wavelengths for a number of unidentified lines are also presented. These unidentified features are discussed with regard to their likely level of excitation and their presence in other novae. This work was supported by the IR&D program of the Aerospace Corporation. RCP acknowledges support from NASA.

A Preliminary Study on the Toxic Combustion Products Testing of Polymers Used in High-Pressure Oxygen Systems

NASA Technical Reports Server (NTRS)

Hshieh, Fu-Yu; Beeson, Harold D.

2004-01-01

One likely cause of polymer ignition in a high-pressure oxygen system is adiabatic-compression heating of polymers caused by pneumatic impact. Oxidative _ pyrolysis or combustion of polymers in a high-pressure oxygen system could generate toxic gases. This paper reports the preliminary results of toxic combustion product testing of selected polymers in a pneumatic-impact test system. Five polymers commonly used in high-pressure oxygen systems, Nylon 6/6, polychlorotrifluoroethylene (CTFE), polytetrafluoroethylene (PTFE), fluoroelastomer (Viton(TradeMark) A), and nitrile rubber (Buna N), were tested in a pneumatic-impact test system at 2500- or 3500-psia oxygen pressure. The polymers were ignited and burned, then combustion products were collected in a stainless-steel sample bottle and analyzed by GC/MS/IRD, GC/FID, and GC/Methanizer/FID. The results of adiabatic-compression tests show that combustion of hydrocarbon polymers, nitrogen-containing polymers, and halogenated polymers in high-pressure oxygen systems are relatively complete. Toxicity of the combustion product gas is presumably much lower than the combustion product gas generated from ambient-pressure oxygen (or air) environments. The NASA-Lewis equilibrium code was used to determine the composition of combustion product gas generated from a simulated, adiabatic-compression test of nine polymers. The results are presented and discussed.

Paleomagnetism of sedimentary cores from the Ross Sea outer shelf and continental slope (PNRA-ROSSLOPE II Project)

NASA Astrophysics Data System (ADS)

Macrì, Patrizia; Sagnotti, Leonardo; Caricchi, Chiara; Colizza, Ester

2016-04-01

We carried out a paleomagnetic and rock magnetic study of 4 gravity cores sampled in the Ross Sea continental slope of the area to the east of Pennell-Iselin banks. The cores (RS14-C1, C2, C3 and ANTA99-C20) consist of hemipelagic fine-grained (silty-clays) sediments with an IRD component. Rock magnetic and paleomagnetic measurements were carried out at 1-cm spacing on u-channel samples. The data indicate that the cored sediments carry a well-defined characteristic remanent magnetization (ChRM) and have a valuable potential to reconstruct dynamics and amplitude of the geomagnetic field variation at high southern latitudes (ca. 75°S) during the Holocene and the late Pleistocene. The paleomagnetic and rock magnetic data are integrated in a multidisciplinary context which includes previous geological, geophysical, oceanographic and morpho-bathimetric data obtained in the same area in the frame of the PNRA/ROSSLOPE (Past and present sedimentary dynamic in the ROSS Sea: a multidisciplinary approach to study the continental slope) Project. The main aim of the project is to investigate the relation between present and past water mass circulation and to provide a basis for paleoceanographic reconstructions and for the development of a depositional model of the modern processes active along the continental slope.

GC-MS and GC-IRD studies on the ring isomers of N-methyl-2-methoxyphenyl-3-butanamines (MPBA) related to 3,4-MDMA.

PubMed

Awad, Tamer; Maher, Hadir M; DeRuiter, Jack; Clark, C Randall

2011-05-01

The mass spectra of the controlled substance 3,4-MDMA and its regioisomer 2,3-MDMA are characterized by an imine fragment base peak at m/z 58 and additional fragments at m/z 135/136 for the methylenedioxybenzyl cation and radical cation, respectively. Three positional ring methoxy isomers of N-methyl-2-(methoxyphenyl)-3-butanamine (MPBA) have an isobaric relationship to 2,3- and 3,4-MDMA. All five compounds have the same molecular weight and produce similar EI mass spectra. This lack of mass spectral specificity for the isomers in addition to the possibility of chromatographic co-elution could result in misidentification. The lack of reference materials for the potential imposter molecules constitutes a significant analytical challenge. Perfluoroacylation of the amine group reduced the nitrogen basicity and provided individual fragmentation pathways for discrimination among these compounds based on unique fragment ions and the relative abundance of common ions. Studies using gas chromatography with infrared detection provided additional structure-IR spectra relationships. The underivatized amines and the perfluoroacylated derivatives (PFPA and HFBA) were resolved by capillary gas chromatography on a 100% dimethylpolysiloxane stationary phase. The perfluoroacylated derivatives showed better resolution on a cyclodextrin modified stationary phase.

Evaluation of a Pitot type spirometer in helium/oxygen mixtures.

PubMed

Søndergaard, S; Kárason, S; Lundin, S; Stenqvist, O

1998-08-01

Mixtures of helium and oxygen are regaining a place in the treatment of obstruction of the upper and lower respiratory tract. The parenchymal changes during the course of IRDS or ARDS may also benefit from the reintroduction of helium/oxygen. In order to monitor and document the effect of low-density gas mixtures, we evaluated the Datex AS/3 Side Stream Spirometry module with D-lite (Datex-Engstrom Instrumentarium Corporation, Finland) against two golden standards. Under conditions simulating controlled and spontaneous ventilation with gas mixtures of He (approx. 80, 50, and 20%)/O2 or N2(approx. 21 and 79%)/02, simultaneous measurements using Biotek Ventilator Tester (Bio-Tek Instr., Vermont, USA) or body plethysmograph (SensorMedics System, Anaheim, USA) were correlated with data from the spirometry module. Data were analyzed according to a statistical regression model resulting in a best-fit equation based on density, voltage, and volume measurements. As expected, the D-lite (a modified Pitot tube) showed density-dependent behaviour. Regression equations and percentage deviation of estimated versus measured values were calculated. Measurements with the D-lite using low-density gases are satisfactorily contained in best-fit equations with a standard deviation of less than 5% during all ventilatory modes and mixtures.

Theoretical studies in interstellar cloud chemistry

NASA Technical Reports Server (NTRS)

Chiu, Y. T.; Prasad, S. S.

1993-01-01

This final report represents the completion of the three tasks under the purchase order no. SCPDE5620,1,2F. Chemical composition of gravitationally contracting, but otherwise quiescent, interstellar clouds and of interstellar clouds traversed by high velocity shocks, were modeled in a comprehensive manner that represents a significant progress in modeling these objects. The evolutionary chemical modeling, done under this NASA contract, represents a notable advance over the 'classical' fixed condition equilibrium models because the evolutionary models consider not only the chemical processes but also the dynamical processes by which the dark interstellar clouds may have assumed their present state. The shock calculations, being reported here, are important because they extend the limited chemical composition derivable from dynamical calculations for the total density and temperature structures behind the shock front. In order to be tractable, the dynamical calculations must severely simplify the chemistry. The present shock calculations take the shock profiles from the dynamical calculations and derive chemical composition in a comprehensive manner. The results of the present modeling study are still to be analyzed with reference to astronomical observational data and other contemporary model predictions. As far as humanly possible, this analysis will be continued with CRE's (Creative Research Enterprises's) IR&D resources, until a sponsor is found.

Paleoenvironmental changes during the past 2000 years, evidence from Kongsfjorden, Svalbard

NASA Astrophysics Data System (ADS)

Jernas, P.; Kristensen, D.; Koc, N.; Skirbekk, K.

2009-04-01

Over the past decades the Arctic has received more attention due to the rapid warming that is more pronounced there than elsewhere on the globe. Instrumental time series are too short to capture the range of natural variability in the Arctic and we therefore have to rely on proxy records to describe the whole range of natural variability. In this context the late-Holocene climate variations are particularly important because natural forcings and the Earth's boundary conditions have been approximately similar to those operating today. Documenting past natural climate variability has therefore a vital role to play in understanding the present climate and predicting future change. Here we present a high resolution marine record from Kongsfjorden covering the last c. 2000 years. The core site is located in Kongsfjorden situated on the western coast of Spitsbergen (Svalbard). We focus on this region because it lies along the path of inflow of warmer and saline subsurface waters via the West Spitsbergen Current which is one of the important heat sources for the Arctic Ocean. This current is a major regulator of environmental changes and for example sea-ice distribution in the west Svalbard area. Therefore quantification of it's spatially and temporally variations through time are essential for understanding past environmental and climate changes. We have investigated faunal variations in benthic foraminifera from the upper 60 cm (covering the last two millennia) of a gravity core (510 cm total length) sampled with one-cm density. Chronology of the gravity core is established by AMS radiocarbon dating. The core was in addition investigated for grain size analysis and x-ray. The sediment analysis and x-ray show the upper part of the core contains large amounts of IRD from 7 cm - 25 cm corresponding to an age of 150-700 cal yr. It indicates that abundant icebergs melted over the core site depositing IRD. Further down core (1000-1800 cal yr) there is a significant dominance of fine grained sediment and decrease in ice rafting indicating less influence from glaciers. The foraminiferal species composition show decreasing content of agglutinated foraminifera down core caused by their low preservation potential. For this core site it confirms the importance of calcareous foraminifera as a fossil record tool. The two dominant species in the core are Elphidium excavatum and Nonionellina labradorica. During the last 2000 years the percentage of E. excavatum shows a general tendency to decrease while N. labradorica increases toward present. Elphidium excavatum is typical for arctic glaciomarine environments close to glaciers and ice caps, indicating harsh conditions (cold bottom waters temperatures, lower salinity) and probably extensive ice cover. Nonionellina labradorica indicates the vicinity of oceanographic fronts and high productivity. Another species Islandiella spp., often associated with increased productivity and presence of the sea ice edge, shows significant increase in percentage from 1000 to 800 cal yr BP. From 600 to 400 cal yr BP Bucella spp. start to decline suggesting increased sea ice cover and diminished influence of the Coastal Current on the inner shelf of Svalbard.

New deglacial and Holocene micropaleontological and geochemical records from the southern margin of the Svalbard Archipelago (Arctic Ocean)

NASA Astrophysics Data System (ADS)

Rigual-Hernández, Andrés.

2010-05-01

This study is presented in the context of the Spanish research project "The development of an Arctic ice stream-dominated sedimentary system: The southern Svalbard continental margin" (SVAIS), developed within the framework of the International Polar Year (IPY) Activity N. 367 (NICE STREAMS). Its main goal is to understand the evolution of glacial continental margins and their relationship with the changes in ice sheet dynamics induced by natural climatic changes, combining the geophysical data with the sediment record both collected during an oceanographic cruise in the Storfjorden area (SW Svalbard margin) in August 2007. This marine depositional system, dominated by an ice stream during the last glacial period, was selected due to its small size inducing a rapid response to climatic changes, and for the oceanographic relevance of the area for global ocean circulation. The results obtained aim to define the sedimentary architecture and morphology, and to provide more insight into the paleoceanographic and paleoclimatic evolution of the region. We specifically report on new micropaleontological and geochemical data obtained from the sediment cores. A preliminary age model indicates that the sediment sequences cover approximately the Last Deglaciation and the Holocene. Microfossils are generally well preserved, although the abundances of the different groups show marked shifts along the record. Low concentrations of coccolithophores, diatoms, planktic foraminifers and cysts of organic-walled dinoflagellates (dinocysts) are found at the lower half of the sequence (IRD-rich, coarser-grained sediments), and increase towards the Late Holocene (fine-grained bioturbated sediments). The Climatic Optimum is characterized by the warmest sea surface temperatures as estimated from the fossil assemblage, diverse transfer functions and biogeochemical proxies, and by high nutrient contents in the bottom waters shown by light carbon isotope values and high Cd/Ca ratios in benthic foraminifers. Dilution by terrigenous material, related to the retreat of the Barents Sea Ice Sheet in response to changes in the strength of the Atlantic-sourced, warm Western Spitsbergen Current, seems to be important in driving the abundances of microfossils and of organic compounds. The different stages of the Deglaciation and the Holocene and the associated modifications in the surface oceanic environment are documented by changes in the fossil assemblage composition of the different microfossil groups, while synchronous changes in the bottom water masses are registered by stable isotope and trace element analyses of benthic foraminifers.

TRACEing Last Glacial Period (25-80 ka b2k) tephra horizons within North Atlantic marine cores and exploring links to the Greenland ice-cores

NASA Astrophysics Data System (ADS)

Abbott, P. M.; Davies, S. M.; Griggs, A. J.; Bourne, A. J.; Cook, E.; Pearce, N. J. G.; Austin, W. E. N.; Chapman, M.; Hall, I. R.; Purcell, C. S.; Scourse, J. D.; Rasmussen, T. L.

2015-12-01

Tephrochronology is a powerful technique for the correlation and synchronisation of disparate palaeoclimatic records from different depositional environments and has considerable potential for testing climatic phasing. For example, the relative timing of atmospheric and marine changes caused by the abrupt climatic events that punctuated the last glacial period within the North Atlantic region. Here we report on efforts to establish a framework of tephra horizons within North Atlantic marine sequences that can correlate these records and if traced in the Greenland ice-cores can act as isochronous tie-lines. Investigations have been conducted on a network of marine cores from a number of sites across the North Atlantic. Tephra horizons have been identified using cryptotephra extraction techniques more commonly applied to the study of terrestrial sequences. There are two main challenges with assessing cryptotephras in the glacial North Atlantic; i) determining the transportation processes and ii) assessing the influence of secondary reworking processes and the stratigraphic integrity of the isochrons. These processes and their influence are investigated for each cryptotephra using shard size variations, major element heterogeneity and co-variance of IRD input for some cores. Numerous Icelandic cryptophras have been successfully identified in the marine records and we will discuss the integration of a number of these with an isochronous nature into a marine tephra framework and how potential correlations to the Greenland ice-core tephra framework are determined. Spatial patterns in the nature of tephra records that are emerging from the core network will be highlighted to outline some of the key areas that could be explored in the future. In addition, the synchronisation of multiple North Atlantic records to the Greenland ice-cores using the North Atlantic Ash Zone II to test the synchroneity of an abrupt cooling in the North Atlantic will be discussed.

Tropical-Subpolar Linkages in the North Atlantic during the last Glacial Period

NASA Astrophysics Data System (ADS)

Vautravers, M. J.; Hodell, D. A.

2010-12-01

We studied millennial-scale changes in planktonic foraminifera assemblages from the last glacial period in a high-resolution core (KN166-14-JPC13) recovered from the southern part of the Gardar Drift in the subpolar North Atlantic. Similar to recent findings reported by Jonkers et al. (2010), we also found that the sub-polar North Atlantic Ocean experienced some seasonal warming during each of the Heinrich Events (HEs). In addition, increasing abundances of tropical species are found just prior to the IRD event marking the end of each Bond cycle, suggesting that summer warming may have been involved in triggering Heinrich events. We suggest that tropical-subtropical water transported via the Gulf Stream and North Atlantic Drift may have triggered the collapse of large NH ice-shelves. Sharp decreases in polar species are tied to abrupt warming following Heinrich Events as documented in Greenland Ice cores and other marine records in the North Atlantic. The record bears a strong resemblance to the tropical record of Cariaco basin (Peterson et al., 2000), suggesting strong tropical-subpolar linkages in the glacial North Atlantic. Enhanced spring productivity, possibly related to eddy activity along the Subpolar Front, is recorded by increased shell size, high δ13C in G. bulloides and other biological indices early during the transition from HE stadials to the following interstadial.

Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs.

PubMed

vonHoldt, Bridgett M; Shuldiner, Emily; Koch, Ilana Janowitz; Kartzinel, Rebecca Y; Hogan, Andrew; Brubaker, Lauren; Wanser, Shelby; Stahler, Daniel; Wynne, Clive D L; Ostrander, Elaine A; Sinsheimer, Janet S; Udell, Monique A R

2017-07-01

Although considerable progress has been made in understanding the genetic basis of morphologic traits (for example, body size and coat color) in dogs and wolves, the genetic basis of their behavioral divergence is poorly understood. An integrative approach using both behavioral and genetic data is required to understand the molecular underpinnings of the various behavioral characteristics associated with domestication. We analyze a 5-Mb genomic region on chromosome 6 previously found to be under positive selection in domestic dog breeds. Deletion of this region in humans is linked to Williams-Beuren syndrome (WBS), a multisystem congenital disorder characterized by hypersocial behavior. We associate quantitative data on behavioral phenotypes symptomatic of WBS in humans with structural changes in the WBS locus in dogs. We find that hypersociability, a central feature of WBS, is also a core element of domestication that distinguishes dogs from wolves. We provide evidence that structural variants in GTF2I and GTF2IRD1 , genes previously implicated in the behavioral phenotype of patients with WBS and contained within the WBS locus, contribute to extreme sociability in dogs. This finding suggests that there are commonalities in the genetic architecture of WBS and canine tameness and that directional selection may have targeted a unique set of linked behavioral genes of large phenotypic effect, allowing for rapid behavioral divergence of dogs and wolves, facilitating coexistence with humans.

Anion-Anion Bonding and Topology in Ternary Iridium Seleno-Stannides.

PubMed

Trump, Benjamin A; Tutmaher, Jake A; McQueen, Tyrel M

2015-12-21

The synthesis and physical properties of two new and one known Ir-Sn-Se compound are reported. Their crystal structures are elucidated with transmission electron microscopy and powder X-ray diffraction. IrSn0.45Se1.55 is a pyrite phase which consists of tilted corner-sharing IrX6 octahedra with randomly distributed (Sn-Se)(4-) and (Se-Se)(2-) dimers. Ir2Sn3Se3 is a known trigonally distorted skutterudite that consists of cooperatively tilted corner-sharing IrSn3Se3 octahedra with ordered (Sn-Se)2(4-) tetramers. Ir2SnSe5 is a layered, distorted β-MnO2 (pyrolusite) structure consisting of a double IrSe6 octrahedral row, corner sharing in the a direction and edge sharing in the b direction. This distorted pyrolusite contains (Se-Se)(2-) dimers and Se(2-) anions, and each double row is "capped" with a (Sn-Se)n polymeric chain. Resistivity, specific heat, and magnetization measurements show that all three have insulating and diamagnetic behavior, indicative of low-spin 5d(6) Ir(3+). Electronic structure calculations on Ir2Sn3Se3 show a single, spherical, nonspin-orbit split valence band and suggest that Ir2Sn3Se3 is topologically nontrivial under tensile strain due to inversion of Ir-d and Se-p states.

Male-specific DNA markers provide genetic evidence of an XY chromosome system, a recombination arrest and allow the tracing of paternal lineages in date palm.

PubMed

Cherif, Emira; Zehdi, Salwa; Castillo, Karina; Chabrillange, Nathalie; Abdoulkader, Sabira; Pintaud, Jean-Christophe; Santoni, Sylvain; Salhi-Hannachi, Amel; Glémin, Sylvain; Aberlenc-Bertossi, Frédérique

2013-01-01

Whether sex chromosomes are differentiated is an important aspect of our knowledge of dioecious plants, such as date palm (Phoenix dactylifera). In this crop plant, the female individuals produce dates, and are thus the more valuable sex. However, there is no way to identify the sex of date palm plants before reproductive age, and the sex-determining mechanism is still unclear. To identify sex-linked microsatellite markers, we surveyed a set of 52 male and 55 female genotypes representing the geographical diversity of the species. We found three genetically linked loci that are heterozygous only in males. Male-specific alleles allowed us to identify the gender in 100% of individuals. These results confirm the existence of an XY chromosomal system with a nonrecombining XY-like region in the date palm genome. The distribution of Y haplotypes in western and eastern haplogroups allowed us to trace two male ancestral paternal lineages that account for all known Y diversity in date palm. The very low diversity associated with Y haplotypes is consistent with clonal paternal transmission of a nonrecombining male-determining region. Our results establish the date palm as a biological model with one of the most ancient sex chromosomes in flowering plants. © 2012 IRD. New Phytologist © 2013 New Phytologist Trust.

Anion–Anion Bonding and Topology in Ternary Iridium Seleno–Stannides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trump, Benjamin A.; Tutmaher, Jake A.; McQueen, Tyrel M.

2015-12-21

The synthesis and physical properties of two new and one known Ir–Sn–Se compound are reported. Their crystal structures are elucidated with transmission electron microscopy and powder X-ray diffraction. IrSn0.45Se1.55 is a pyrite phase which consists of tilted corner-sharing IrX6 octahedra with randomly distributed (Sn–Se)4– and (Se–Se)2– dimers. Ir2Sn3Se3 is a known trigonally distorted skutterudite that consists of cooperatively tilted corner-sharing IrSn3Se3 octahedra with ordered (Sn–Se)24– tetramers. Ir2SnSe5 is a layered, distorted β-MnO2 (pyrolusite) structure consisting of a double IrSe6 octrahedral row, corner sharing in the a direction and edge sharing in the b direction. This distorted pyrolusite contains (Se–Se)2– dimersmore » and Se2– anions, and each double row is “capped” with a (Sn–Se)n polymeric chain. Resistivity, specific heat, and magnetization measurements show that all three have insulating and diamagnetic behavior, indicative of low-spin 5d6 Ir3+. Electronic structure calculations on Ir2Sn3Se3 show a single, spherical, nonspin–orbit split valence band and suggest that Ir2Sn3Se3 is topologically nontrivial under tensile strain due to inversion of Ir-d and Se-p states.« less

Fuel poverty as a major determinant of perceived health: the case of France.

PubMed

Lacroix, E; Chaton, C

2015-05-01

The number of households in fuel poverty is growing. Individuals increasingly struggle to heat their homes, and therefore, a growing number of individuals are exposed to low temperatures, which can affect their health. This study sought to determine the link between a subjective measure of fuel poverty (self-reported feeling cold) and self-reported health. The impact of other particular individual and environmental features on self-reported health were also analysed. Econometric analysis. The study method uses self-reported perception of thermal discomfort (self-reported feeling cold) as a proxy for fuel poverty. The French database of the Healthcare and Insurance survey carried by the Institute for Research and Information on Health Economics (IRDES) was used to estimate a dichotomous probit model. The estimation allows us to infer a negative impact of fuel poverty on self-reported health. Thus, a person in fuel poverty is 2.36 percentage points more likely to report poor or fair health status than a person who is not in fuel poverty. It may be appropriate to reduce the impacts of fuel poverty to provide support for the most vulnerable categories of individuals with respect to the health impacts of fuel poverty and cold homes, e.g., chronic patients who experience difficulty heating their homes. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Sediment property changes in response to the glacial activity on the continental slope to the eastern side of Pennell-Iselin Bank in the Ross Sea, Antarctica

NASA Astrophysics Data System (ADS)

Ha, Sangbeom; Khim, Boo-Keun; Colizza, Ester; Marci, Patrizia; Sagnotti, Leonardo; Caricchi, Chiara; Langone, Leonardo; Giglio, Federico; Kuhn, Gerhard

2017-04-01

High latitude marine environments including the Antarctic continental margin have sensitively responded to the climate change, and the Ross Sea is one of these examples. Subglacial marine sedimentary changes have been studied extensively in the continental shelf areas of the Ross Sea to understand the growth and retreat of glaciers in response to the glacial-interglacial changes. However, the continental slope areas of the Ross Sea have not been investigated comparatively less. Thus, in order to comprehend the glaciomarine sedimentation change on the continental slope of the Ross Sea, 3 gravity cores (GC1, GC2, GC3) and 3 box cores (BC1, BC2, BC3) were collected from 3 sites (RS14-C1, C2, C3 by decreasing water depth), respectively, across the continental slope to the eastern side of the Pennell-Iselin Bank during XXIX PNRA (Rosslope II) cruise in 2014. A variety of sedimentological (grain size, magnetic susceptibility, XRF) and geochemical (biogenic opal, total organic carbon, CaCO3, δ13C of organic matter) properties were analyzed along with AMS 14C dating of bulk sediments. All core sediments consist of mostly hemipelagic sandy clay or silty clay with scattered IRD (Ice-Rafted Debris). Sediment color of three cores changes consistently downward from brown to gray with some alternations in core GC1. Based on the basic sediment properties such as sediment color, grain size, and magnetic susceptibility, sediment lithology was decided to divide Unit A and Unit B, both of which were further divided into two subunits. Despite old carbon effect, AMS 14C dates confirm that Unit A belongs to the Holocene and Unit B covers the deglacial to last glacial period at the top of cores. Unit A is characterized by low TOC, low CaCO3, low biogenic opal content and low C/N ratios, whereas Unit B is characterized by high TOC, high CaCO3, moderate to high biogenic opal content and high C/N ratios. Consequently, Unit A represents the modern and interglacial sediments deposited mainly by the suspension settling of biogenic particles in the open marine condition. In contrast, because Unit B shows higher TOC, CaCO3 content and C/N ratios, these sediments might be supplied by the lateral melt-water plume or distal part of debris flow originated from the front of grounding ice in the subglacial continental shelf under the ice shelf and during the glacial or post-glacial period. Thus, Unit B contains mostly reworked and eroded continental shelf sediments and IRDs. In addition, because the peaks of biogenic opal and TOC contents at Site C1 are distinctly higher than Sites C2 and C3, surface water production occurred under seasonally open marine condition at the deeper Site C1. In conclusion, the influence of subglacial continental shelf sedimentation in terms of melt-water transport and/or distal stage of debris flow was limited as far as to Site C2 during the deglacial and glacial period. However, such depositional effect was insignificant, but the seasonal open marine condition was recognized, at the deeper Site C1 in the continental slope of the Ross Sea.

Late Quaternary Paleoceanographic Settings in the Central Arctic Ocean as Revealed from the Composition of Coarse Grains on the Alpha-Mendeleev and Lomonosov Ridges

NASA Astrophysics Data System (ADS)

Bazhenova, E.; Spielhagen, R. F.; Kudryavtseva, A.; Voronovich, E.; Stein, R. H.; Krylov, A.

2017-12-01

In the central Arctic Ocean, circulation of surface oceanic currents and trajectories of sea-ice drift generally follow the two main systems, the Beaufort Gyre and the Transpolar Drift. The boundary between the two systems is located above the Lomonosov Ridge but might have been shifted over the Quaternary glacial/interglacial cycles due to changing water masses, sea-ice cover, and wind patterns. Changes in sediment core composition can provide information about the different source areas of material reaching the central part of the Arctic basin, and hence, about the driving paleaoceanographic settings. We will summarize results of completed and ongoing investigations performed on several sediment cores recovered by the German RV "Polarstern" in 2007, 2008, and 2014: PS72/340-5, and PS72/344-3 - on the Mendeleev Ridge; PS70/330-1, and PS70/342-1 - on the Alpha Ridge; PS87/023-1, PS87/030-1, PS87/056-1, and PS2185 - on the Lomonosov Ridge. We focused on the petrographic classification of coarse grains (>0.5 mm) isolated from the sediments. Identification of grain composition was done using an optical binocular. Additionally, grain surface was treated with HCL 10%-solution to check for the presence of detrital carbonates. Clast types were classified following published studies from the Mendeleev and Lomonosov ridges which utilized the same size fractions. The studied cores span the last two glacial/interglacial cycles (ca. 200 kyrs). On the Mendeleev Ridge, total grain counts decrease towards the East Siberian margin (from core PS72/340 to core PS72/344), similar to the bulk dolomite content and the amount of larger dropstones. Sediments are generally very fine-grained throughout the cores. Peaks of all clast types in these two cores are synchronous, probably indicating events of abrupt iceberg discharge. Morphometry of larger dropstones (>2 cm) in these cores clearly indicates iceberg transportation. In cores PS87/056-1 and PS87/070-1 (central Lomonosov Ridge), quartz and carbonate peaks are not observed simultaneously, which can be indicative of two different source areas supplying IRD to these core sites. Morphometry of larger dropstones (>2 cm) indicates both iceberg and sea-ice transport; some material holds evidence of riverine transportation.

International Congress on Transposable Elements (ICTE) 2012 in Saint Malo and the sea of TE stories.

PubMed

Ainouche, Abdelkader; Bétermier, Mireille; Chandler, Mick; Cordaux, Richard; Cristofari, Gaël; Deragon, Jean-Marc; Lesage, Pascale; Panaud, Olivier; Quesneville, Hadi; Vaury, Chantal; Vieira, Cristina; Vitte, Clémentine

2012-10-30

An international conference on Transposable Elements (TEs) was held 21-24 April 2012 in Saint Malo, France. Organized by the French Transposition Community (GDR Elements Génétiques Mobiles et Génomes, CNRS) and the French Society of Genetics (SFG), the conference's goal was to bring together researchers from around the world who study transposition in diverse organisms using multiple experimental approaches. The meeting drew more than 217 attendees and most contributed through poster presentations (117), invited talks and short talks selected from poster abstracts (48 in total). The talks were organized into four scientific sessions, focused on: impact of TEs on genomes, control of transposition, evolution of TEs and mechanisms of transposition. Here, we present highlights from the talks given during the platform sessions. The conference was sponsored by Alliance pour les sciences de la vie et de la santé (Aviesan), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut de recherche pour le développement (IRD), Institut national de la recherche agronomique (INRA), Université de Perpignan, Université de Rennes 1, Région Bretagne and Mobile DNA. CHAIR OF THE ORGANIZATION COMMITTEE: Jean-Marc Deragon ORGANIZERS: Abdelkader Ainouche, Mireille Bétermier, Mick Chandler, Richard Cordaux, Gaël Cristofari, Jean-Marc Deragon, Pascale Lesage, Didier Mazel, Olivier Panaud, Hadi Quesneville, Chantal Vaury, Cristina Vieira and Clémentine Vitte.

Adaptive optics at the Subaru telescope: current capabilities and development

NASA Astrophysics Data System (ADS)

Guyon, Olivier; Hayano, Yutaka; Tamura, Motohide; Kudo, Tomoyuki; Oya, Shin; Minowa, Yosuke; Lai, Olivier; Jovanovic, Nemanja; Takato, Naruhisa; Kasdin, Jeremy; Groff, Tyler; Hayashi, Masahiko; Arimoto, Nobuo; Takami, Hideki; Bradley, Colin; Sugai, Hajime; Perrin, Guy; Tuthill, Peter; Mazin, Ben

2014-08-01

Current AO observations rely heavily on the AO188 instrument, a 188-elements system that can operate in natural or laser guide star (LGS) mode, and delivers diffraction-limited images in near-IR. In its LGS mode, laser light is transported from the solid state laser to the launch telescope by a single mode fiber. AO188 can feed several instruments: the infrared camera and spectrograph (IRCS), a high contrast imaging instrument (HiCIAO) or an optical integral field spectrograph (Kyoto-3DII). Adaptive optics development in support of exoplanet observations has been and continues to be very active. The Subaru Coronagraphic Extreme-AO (SCExAO) system, which combines extreme-AO correction with advanced coronagraphy, is in the commissioning phase, and will greatly increase Subaru Telescope's ability to image and study exoplanets. SCExAO currently feeds light to HiCIAO, and will soon be combined with the CHARIS integral field spectrograph and the fast frame MKIDs exoplanet camera, which have both been specifically designed for high contrast imaging. SCExAO also feeds two visible-light single pupil interferometers: VAMPIRES and FIRST. In parallel to these direct imaging activities, a near-IR high precision spectrograph (IRD) is under development for observing exoplanets with the radial velocity technique. Wide-field adaptive optics techniques are also being pursued. The RAVEN multi-object adaptive optics instrument was installed on Subaru telescope in early 2014. Subaru Telescope is also planning wide field imaging with ground-layer AO with the ULTIMATE-Subaru project.

Low Cost Manufacturing Approach of High Temperature PMC Components

NASA Technical Reports Server (NTRS)

Kannmacher, Kevin

1997-01-01

The overall objective is to develop a satisfactory sheet molding compound (SMC) of a high temperature polyimide, such as PMR-11-50, VCAP-75, or NB2-76, and to develop compression molding processing parameters for a random, chopped fiber, high temperature, sheet molding compound that will be more affordable than the traditional hand lay-up fabrication methods. Compression molding will reduce manufacturing costs of composites by: (1) minimizing the conventional machining required after fabrication due to the use of full 360 deg matched tooling, (2) reducing fabrication time by minimizing the intensive hand lay-up operations associated with individual ply fabrication techniques, such as ply orientation and ply count and (3) possibly reducing component mold time by advanced B-staging prior to molding. This program is an integral part of Allison's T406/AE engine family's growth plan, which will utilize technologies developed under NASA's Sub-sonic Transport (AST) programs, UHPTET initiatives, and internally through Allison's IR&D projects. Allison is aggressively pursuing this next generation of engines, with both commercial and military applications, by reducing the overall weight of the engine through the incorporation of advanced, lightweight, high temperature materials, such as polymer matrix composites. This infusion of new materials into the engine is also a major factor in reducing engine cost because it permits the use of physically smaller structural components to achieve the same thrust levels as the generation that it replaced. A lighter, more efficient propulsion system translates to a substantial cost and weight savings to an airframe's structure.

Effects of midlatitude westerlies on the paleoproductivity at the Agulhas Bank slope during the penultimate glacial cycle: Evidence from coccolith Sr/Ca ratios

NASA Astrophysics Data System (ADS)

Mejia, Luz Maria; Ziveri, Patrizia; Cagnetti, Marilisa; Bolton, Clara; Zahn, Rainer; Marino, Gianluca; Martinez Mendez, Gema; Stoll, Heather

2015-04-01

Because modern primary productivity on the Agulhas Bank, off South Africa, is linked to the mid-latitude westerlies, a paleoproductivity record from this area could be used to investigate past may changes in the westerlies dynamics. Coccolith Sr/Ca is a suitable productivity indicator to explore paleoproductivity from the penultimate glacial-interglacial cycle because it is independent of preservation changes that may accompany changes in deepwater circulation. In the Agulhas Bank slope core MD96-2080, the coccolith Sr/Ca record shows that phases of depressed productivity coincided with periods of stratification in the same core, indicated by high relative abundances of the coccolithophore Florisphaera profunda, and with low relative abundances of the upwelling indicator G. bulloides in the Cape Basin. This coherence suggests that upwelling regulated productivity throughout this region. As in the present, we infer that periods of low productivity result from northward positions of the westerlies which block the upwelling-promoting easterlies. Productivity minima also coincide with periods of increased ice-rafted detritus (IRD) deposition on the Agulhas Plateau, which also indicates extreme northward positions of the westerlies. The influence of the westerlies appears to be obliquity-conditioned, as productivity minima occur during low obliquity intervals. The dynamic connection between productivity and the westerlies is supported by coeval salinity changes in the South Indian Gyre that likewise respond sensitively to a poleward contraction of the westerlies.

Highly variable Pliocene sea surface conditions in the Norwegian Sea

NASA Astrophysics Data System (ADS)

Bachem, Paul E.; Risebrobakken, Bjørg; De Schepper, Stijn; McClymont, Erin L.

2017-09-01

The Pliocene was a time of global warmth with small sporadic glaciations, which transitioned towards the larger-scale Pleistocene glacial-interglacial variability. Here, we present high-resolution records of sea surface temperature (SST) and ice-rafted debris (IRD) in the Norwegian Sea from 5.32 to 3.14 Ma, providing evidence that the Pliocene surface conditions of the Norwegian Sea underwent a series of transitions in response to orbital forcing and gateway changes. Average SSTs are 2 °C above the regional Holocene mean, with notable variability on millennial to orbital timescales. Both gradual changes and threshold effects are proposed for the progression of regional climate towards the Late Pliocene intensification of Northern Hemisphere glaciation. Cooling from 4.5 to 4.3 Ma may be linked to the onset of poleward flow through the Bering Strait. This cooling was further intensified by a period of cool summers due to weak obliquity forcing. A 7 °C warming of the Norwegian Sea at 4.0 Ma suggests a major increase in northward heat transport from the North Atlantic, leading to an enhanced zonal SST gradient in the Nordic Seas, which may be linked to the expansion of sea ice in the Arctic and Nordic Seas. A warm Norwegian Sea and enhanced zonal temperature gradient between 4.0 and 3.6 Ma may have been a priming factor for increased glaciation around the Nordic Seas due to enhanced evaporation and precipitation at high northern latitudes.

Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension

PubMed Central

Del Campo, Miguel; Antonell, Anna; Magano, Luis F.; Muñoz, Francisco J.; Flores, Raquel; Bayés, Mònica; Pérez Jurado, Luis A.

2006-01-01

Williams-Beuren syndrome (WBS), caused by a heterozygous deletion at 7q11.23, represents a model for studying hypertension, the leading risk factor for mortality worldwide, in a genetically determined disorder. Haploinsufficiency at the elastin gene is known to lead to the vascular stenoses in WBS and is also thought to predispose to hypertension, present in ∼50% of patients. Detailed clinical and molecular characterization of 96 patients with WBS was performed to explore clinical-molecular correlations. Deletion breakpoints were precisely defined and were found to result in variability at two genes, NCF1 and GTF2IRD2. Hypertension was significantly less prevalent in patients with WBS who had the deletion that included NCF1 (P=.02), a gene coding for the p47phox subunit of the NADPH oxidase. Decreased p47phox protein levels, decreased superoxide anion production, and lower protein nitrotyrosination were all observed in cell lines from patients hemizygous at NCF1. Our results indicate that the loss of a functional copy of NCF1 protects a proportion of patients with WBS against hypertension, likely through a lifelong reduced angiotensin II–mediated oxidative stress. Therefore, antioxidant therapy that reduces NADPH oxidase activity might have a potential benefit in identifiable patients with WBS in whom serious complications related to hypertension have been reported, as well as in forms of essential hypertension mediated by a similar pathogenic mechanism. PMID:16532385

Discharge of water and sediment from ice-streams on the southeastern Laurentide Ice Sheet during Heinrich events: timing and magnitude

NASA Astrophysics Data System (ADS)

Rashid, H.; Piper, D.

2017-12-01

Several ice-streams on the southeastern sector of the Laurentide Ice Sheet discharged icebergs, meltwater, and fine-grained sediments into the North Atlantic during Heinrich (H) events. The principal contribution was through Hudson Strait, which is the only source clearly identified in H ice-rafted layers in the central North Atlantic. The role of direct supply of meltwater in modifying the Atlantic meridional circulation generally has been regarded as secondary. The relative chronology of discharge in different ice-streams is poorly known. Here, we re-assess these questions using continental margin cores constrained by high-resolution seismic profiles and multibeam bathymetry data. Relative importance of ice streams likely scales with cross-sectional area of their erosional troughs. On that basis, the Hudson Strait ice stream was twice as large as that in the Laurentian Channel and 3-4 times larger than smaller troughs. Several ice streams supplied petrographically and geochemically distinct sediment including black shales from Cumberland Sound, limestone and dolomite in particular proportions from Frobisher Bay and Hudson Strait, and red sandstones and shales ± carbonates from NE Newfoundland and Laurentian Channel. In several cases, detrital carbonate H layers derived predominantly from Hudson Strait are preceded by enhanced IRD deposition from smaller ice streams, e.g. deposits from Cumberland Sound on the Labrador slope, from NE Newfoundland in Orphan Basin, and from Laurentian Channel on the Nova Scotian margin. Gravel petrology indicates that Hudson Strait sources make up >90% of the ice-rafted component of distal H layers. H layers proximal to the Hudson Strait ice-streams are 4 to 12 meters thick compared to a few centimeters thick seaward of the Trinity Trough and Laurentian ice-streams, comparable to the thickness of the North Atlantic. This underscores the great importance of meltwater and suspended sediment close to ice stream outlets. Morphological features and plume deposits show that meltwater becomes much more abundant in more southerly ice streams and some local plume deposits contribute to the thickness of H layers. The contribution of freshwater from melting icebergs and from direct meltwater discharge are approximately similar during H events.

The One Micron Fe II Lines in Active Galaxies and Emission Line Stars

NASA Astrophysics Data System (ADS)

Rudy, R. J.; Mazuk, S.; Puetter, R. C.; Hamann, F. W.

1999-05-01

The infrared multiplet of Fe II lines at 0.9997, 1.0501, 1.0863, and 1.1126 microns are particularly strong relative to other red and infrared Fe II features. They reach their greatest strength, relative to the hydrogen lines, in the Seyfert 1 galaxy I Zw 1, and are a common, although not ubiquitous feature, in the broad line regions of active galaxies. In addition, they are seen in a diverse assortment of Galactic sources including young stars, Herbig Ae and Be stars, luminous blue variables, proto-planetary nebulae, and symbiotic novae. They are probably excited by Lyman alpha florescence but the exact path of the cascade to their upper levels is uncertain. They arise in dense, sheltered regions of low ionization and are frequently observed together with the infrared Ca II triplet and the Lyman beta excited O I lines 8446 and 11287. The strengths of the four Fe II features, relative to each other, are nearly constant from object to object suggesting a statistical population of their common upper multiplet. Their intensities, in comparison to the Paschen lines, indicate that they can be important coolants for regions with high optical depths in the hydrogen lines. In addition to I Zw 1 and other active galaxies, we present spectra for the Galactic sources MWC 17, MWC 84, MWC 340, MWC 922, PU Vul, and M 1-92. We review the status of the Fe II observations and discuss the excitation process and possible implications. This work was supported by the IR&D program of the Aerospace Corporation. RCP and FWH acknowledge support from NASA.

Transportation technology program: Strategic plan

NASA Astrophysics Data System (ADS)

1991-09-01

The purpose of this report is to define the technology program required to meet the transportation technology needs for current and future civil space missions. It is a part of an integrated plan, prepared by NASA in part in response to the Augustine Committee recommendations, to describe and advocate expanded and more aggressive efforts in the development of advanced space technologies. This expanded program will provide a technology basis for future space missions to which the U.S. aspires, and will help to regain technology leadership for the U.S. on a broader front. The six aspects of this integrated program/plan deal with focused technologies to support space sciences, exploration, transportation, platforms, and operations as well as provide a Research and Technology Base Program. This volume describes the technologies needed to support transportation systems, e.g., technologies needed for upgrades to current transportation systems and to provide reliable and efficient transportation for future space missions. The Office of Aeronautics, Exploration, and Technology (OAET) solicited technology needs from the major agency technology users and the aerospace industry community and formed a transportation technology team (appendix A) to develop a technology program to respond to those needs related to transportation technologies. This report addresses the results of that team activity. It is a strategic plan intended for use as a planning document rather than as a project management tool. It is anticipated that this document will be primarily utilized by research & technology (R&T) management at the various NASA Centers as well as by officials at NASA Headquarters and by industry in planning their corporate Independent Research and Development (IR&D) investments.

Transportation technology program: Strategic plan

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose of this report is to define the technology program required to meet the transportation technology needs for current and future civil space missions. It is a part of an integrated plan, prepared by NASA in part in response to the Augustine Committee recommendations, to describe and advocate expanded and more aggressive efforts in the development of advanced space technologies. This expanded program will provide a technology basis for future space missions to which the U.S. aspires, and will help to regain technology leadership for the U.S. on a broader front. The six aspects of this integrated program/plan deal with focused technologies to support space sciences, exploration, transportation, platforms, and operations as well as provide a Research and Technology Base Program. This volume describes the technologies needed to support transportation systems, e.g., technologies needed for upgrades to current transportation systems and to provide reliable and efficient transportation for future space missions. The Office of Aeronautics, Exploration, and Technology (OAET) solicited technology needs from the major agency technology users and the aerospace industry community and formed a transportation technology team (appendix A) to develop a technology program to respond to those needs related to transportation technologies. This report addresses the results of that team activity. It is a strategic plan intended for use as a planning document rather than as a project management tool. It is anticipated that this document will be primarily utilized by research & technology (R&T) management at the various NASA Centers as well as by officials at NASA Headquarters and by industry in planning their corporate Independent Research and Development (IR&D) investments.

Magnetic signatures of Heinrich-like detrital layers in the Quaternary of the North Atlantic

NASA Astrophysics Data System (ADS)

Channell, J. E. T.; Hodell, D. A.

2013-05-01

Magnetic parameters are useful for distinguishing North Atlantic Heinrich-like detrital layers from background sediments. Here we compare magnetic properties with XRF scanning data back to 700 ka and 1.3 Ma at IODP Sites U1302-U1303 and U1308, respectively. Multi-domain magnetite, with grain sizes >20 µm, is characteristic of both Ca- and Si-rich detrital layers, as defined by XRF core scanning, confirming the contribution of ice rafting. Reflectance spectra and magnetic parameters distinguish Ca- and Si-rich IRD layers due the presence of high coercivity hematite in Si-rich layers. Heinrich layer 6 (H6) at Site U1302-U1303 is unlike other detrital layers, being marked by a 45-cm thick homogeneous cream-colored clay layer underlain by a thin (5-cm) graded coarse-sand. Comparison of Site U1302/03 and Site U1308 detrital layers implies a dominant Laurentide source for both Ca- and Si-rich detrital layers. At Site U1308, low benthic δ13C values during stadials are in-step with magnetic grain-size coarsening associated with Si-rich detrital layers back to 1.3 Ma, indicating a link between deep-sea ventilation and ice rafting. The surface-sediment tan-colored oxic layer (~2 m thick at Site U1308) yields magnetic hysteresis ratios that are offset from the single-domain to multi-domain (SD-MD) magnetite mixing-line in hysteresis-ratio diagrams. This offset is attributed to maghemite grain-coatings, that form on magnetite in surface sediment, and undergo dissolution as they pass through the oxic/anoxic boundary.

The ADN project : an integrated seismic monitoring of the northern Ecuadorian subduction

NASA Astrophysics Data System (ADS)

Nocquet, Jean-Mathieu; Yepes, Hugo; Vallee, Martin; Mothes, Patricia; Regnier, Marc; Segovia, Monica; Font, Yvonne; Vaca, Sandro; Bethoux, Nicole; Ramos, Cristina

2010-05-01

The subduction of the Nazca plate beneath South America has caused one of the largest megathrust earthquake sequence during the XXth century with three M>7.7 earthquakes that followed the great 1906 (Mw = 8.8) event. Better understanding the processes leading to the occurrence of large subduction earthquakes requires to monitor the ground motion over a large range of frequencies. We present a new network (ADN) developed under a collaboration between the IRD-GeoAzur (Nice, France) and the IG-EPN (Quito, Ecuador). Each station of the ADN network includes a GPS recording at 5 Hz, an accelerometer and a broadband seismometer. CGPS data will quantify the secular deformation induced by elastic locking along the subduction interface, enabling a detailed modelling of the coupling distribution. CGPS will be used to monitor any transient deformation induced by Episodic Slip Event along the subduction, together with broadband seismometers that can detect any tremors or seismic signatures that may accompany them. In case of any significant earthquake, 5 Hz GPS and accelerometer will provide near field data for earthquake source detailed study. Finally, the broadband seismometers will be used for study of the microseismicity and structure of the subduction zone. The network includes 9 stations, operating since 2008 and covering the coastal area from latitude 1.5°S to the Colombian border. In this poster, we will present preliminary assessment of the data, first hypocenters location, magnitude and focal mechanism determination, as well as results about an episodic slip event detected in winter 2008.

Plio-Pleistocene evolution of water mass exchange and erosional input at the Atlantic-Arctic gateway

NASA Astrophysics Data System (ADS)

Teschner, Claudia; Frank, Martin; Haley, Brian A.; Knies, Jochen

2016-05-01

Water mass exchange between the Arctic Ocean and the Norwegian-Greenland Seas has played an important role for the Atlantic thermohaline circulation and Northern Hemisphere climate. We reconstruct past water mass mixing and erosional inputs from the radiogenic isotope compositions of neodymium (Nd), lead (Pb), and strontium (Sr) at Ocean Drilling Program site 911 (leg 151) from 906 m water depth on Yermak Plateau in the Fram Strait over the past 5.2 Myr. The isotopic compositions of past bottom waters were extracted from authigenic oxyhydroxide coatings of the bulk sediments. Neodymium isotope signatures obtained from surface sediments agree well with present-day deepwater ɛNd signature of -11.0 ± 0.2. Prior to 2.7 Ma the Nd and Pb isotope compositions of the bottom waters only show small variations indicative of a consistent influence of Atlantic waters. Since the major intensification of the Northern Hemisphere Glaciation at 2.7 Ma the seawater Nd isotope composition has varied more pronouncedly due to changes in weathering inputs related to the waxing and waning of the ice sheets on Svalbard, the Barents Sea, and the Eurasian shelf, due to changes in water mass exchange and due to the increasing supply of ice-rafted debris (IRD) originating from the Arctic Ocean. The seawater Pb isotope record also exhibits a higher short-term variability after 2.7 Ma, but there is also a trend toward more radiogenic values, which reflects a combination of changes in input sources and enhanced incongruent weathering inputs of Pb released from freshly eroded old continental rocks.

Surface water - groundwater relationship in the downstream part of the Komadougou Yobe River (Eastern Sahelian Niger)

NASA Astrophysics Data System (ADS)

Hector, B.; Genthon, P.; Luxereau, A.; Descloîtres, M.; Moumouni Moussa, A.; Abdou, H.

2012-04-01

The Komadougou Yobe (KY) is a temporary river meandering on nearly 100 km along the Niger/Nigeria border in its lower part, before reaching the endoreic Lake Chad. There, seasonal flow from July to January is related to rainfall amount on the upstream Jos Plateau, Nigeria. In the semi-arid downstream area (350 mm annual rainfall in Diffa, Niger) the KY is the main source of recharge for the sandy quaternary aquifer which is used both for irrigation and for drinking water supply. The borders of the KY in Niger are subjected to an agricultural development involving intensive irrigated cropping of sweet pepper mainly produced for sale in Nigeria. Irrigation waters are mainly extracted from the KY, and therefore irrigation must stop when the River runs dry, but irrigation from wells is now developing with an increased risk of soil salinization. The flow rate of the KY has been impacted both by the 80s and 90s droughts, also underwent by the entire Sahel, and by the building up of a series of dams starting from the 70s in Nigeria. Therefore the KY and its relations with the underlying groundwaters should be carefully monitored to provide guidelines for policy makers in charge of the development of this area. However, in this remote area, data are scarce and often discontinuous : there are for example no continuous groundwater level data from before the drought. As part of the Lake Chad French IRD project, series of campaigns involving water level, exploration geophysics, gravity, soil sampling and social studies have been carried out between 2008 and 2011. They allowed to build a numerical model for groundwater-river interactions which in some instances has been compared with previously recorded data. This model is then forced with theoretical climatic senarii based on humid 60s data and data from the drought period. This allows discussing the relationships between the river and groundwaters in a changing climate. Our results militate for the setting up of a limited network of continuous groundwater monitoring near the river in conjunction with the existing network of gauging stations on the KY. Given the present day high variability of the climate (2010 was equivalent to one of the most humid years of the 60s, while 2005 was dry) this network could provide a validation for future models involving realistic climate senarii.

Isochron burial dating of the Haslau terrace of the Danube (Vienna Basin) and interlaboratory comparison of sample preparation in Vienna and Budapest

NASA Astrophysics Data System (ADS)

Ruszkiczay-Rüdiger, Zsófia; Neuhuber, Stephanie; Decker, Kurt; Braucher, Régis; Fiebig, Marcus; Braun, Mihály; Lachner, Johannes; Aster Team

2017-04-01

In the Vienna Basin, terraces to the South of the Danube form a staircase with altitudes ranging between 25 and 130 m above current water level. The terrace system has been strongly dissected by faults related to the sinistral movement of the Vienna Basin Transform Fault System [1, 2]. Although each fault block displays a slightly different succession of terraces, fault-related vertical displacements south of the Danube have not yet been quantified. To better understand the Quaternary terrace sequence and its displacement along a fault segment south of the Danube, the isochron burial dating method [3] based on the 26Al and 10Be cosmogenic nuclide pair has been used on a terrace at Haslau an der Donau (˜40 m above river level). This terrace is locally the lowest of a staircase of a total of 6 different levels. Based on geomorphological mapping, its age was considered to be Middle Pleistocene [4]. The sample set consisted of several quartzite cobbles taken from two sedimentary units (5.5 m and 11.8 m depth) separated by an erosional hiatus of unknown duration. Six cobbles were selected for inter-laboratory comparison and processed at both the Cosmogenic Nuclide Sample Preparation Laboratory at Vienna and at Budapest [5]. AMS measurements were performed at the French national facility ASTER (CEREGE, Aix-en-Provence) and at the Vienna Environmental Research Accelerator (VERA). Initially, the obtained results show that the 10Be and 26Al concentrations calculated from the subsamples processed independently using different extraction schemes at both laboratories overlap within error for all subsamples but one, whose 26Al concentrations were significantly different. The low 26Al concentration measured in one Budapest sample probably resulted from Al having been trapped within the insoluble residues observed after evaporation to dryness. A modification of the sample processing allows overcoming this difficulty while treating for the following sample set. The results demonstrate that the laboratory background is safe for in-situ produced cosmogenic 10Be and 26Al extraction at both Vienna and Budapest laboratories and that the different geochemical digestion and purification schemes applied by the two laboratories for the extraction of 10Be and 26Al lead to similar results. A preliminary (not corrected) isochron burial age of ˜2.4 Ma was calculated for the higher sedimentary unit of the Haslau terrace on the basis of the slope of the isochron. This age is significantly older than the Middle Pleistocene age previously estimated. Further age determinations are nevertheless necessary to decide whether this preliminary age is accurate or not. Thanks to OTKA PD83610, OMAA 90öu17; LP2012-27/2012. INSU/CNRS, the ANR through the program "EQUIPEX Investissement d'Avenir" and IRD. References: [1] Decker et al., 2005. QSR 24, 307-322. [2] Salcher et al., 2012. Tectonics 31, 1-20. [3] Balco and Rovey, 2008. AJS 908, 1083-1114 [4] Fuchs and Grill, 1984. Geologische Karte von Wien und Umgebung (1:200.000) [5] http://www.geochem.hu/kozmogen/Lab_en.html

The RBV metadata catalog

NASA Astrophysics Data System (ADS)

Andre, Francois; Fleury, Laurence; Gaillardet, Jerome; Nord, Guillaume

2015-04-01

RBV (Réseau des Bassins Versants) is a French initiative to consolidate the national efforts made by more than 15 elementary observatories funded by various research institutions (CNRS, INRA, IRD, IRSTEA, Universities) that study river and drainage basins. The RBV Metadata Catalogue aims at giving an unified vision of the work produced by every observatory to both the members of the RBV network and any external person interested by this domain of research. Another goal is to share this information with other existing metadata portals. Metadata management is heterogeneous among observatories ranging from absence to mature harvestable catalogues. Here, we would like to explain the strategy used to design a state of the art catalogue facing this situation. Main features are as follows : - Multiple input methods: Metadata records in the catalog can either be entered with the graphical user interface, harvested from an existing catalogue or imported from information system through simplified web services. - Hierarchical levels: Metadata records may describe either an observatory, one of its experimental site or a single dataset produced by one instrument. - Multilingualism: Metadata can be easily entered in several configurable languages. - Compliance to standards : the backoffice part of the catalogue is based on a CSW metadata server (Geosource) which ensures ISO19115 compatibility and the ability of being harvested (globally or partially). On going tasks focus on the use of SKOS thesaurus and SensorML description of the sensors. - Ergonomy : The user interface is built with the GWT Framework to offer a rich client application with a fully ajaxified navigation. - Source code sharing : The work has led to the development of reusable components which can be used to quickly create new metadata forms in other GWT applications You can visit the catalogue (http://portailrbv.sedoo.fr/) or contact us by email rbv@sedoo.fr.

Women researchers lead wage hikes

NASA Astrophysics Data System (ADS)

Bell, Peter M.

Women employed in the research and development fields in universities, government, and industry made substantial increases and lead men in salary gains in 1981, according to a far-reaching survey of 5000 respondents (Industrial Research and Development, April 1982). At the upper end, 20% of women researchers received salary increases of 14% or more, compared to 13% of the men. The raises were high in 1981; more than half the women in research and development had salary gains of over 9%.The employment picture for women in the scientific and technical fields is somewhat complicated by the affirmative efforts of hiring. More women were hired in 1981, and most newly hired women and men begin at the lowest salaries. This factor contributed to the reality that more women than men at the lower salary ranges received zero raises. However, according to the survey, this is not a trend, since the current efforts to add women in research fields are providing more rewards for women per amount of experience than for men: “…women working in R&D have far less experience than their male counterparts.” (IR&D, op cit.). The median years of experience is down in 1981 from previous years. Some 40% of the women surveyed had less than 6 years experience, compared to about 14% of the men. These figures contrast with those of the survey trends of previous years, which indicated a direct relation between salary and experience. It is still true that because larger numbers of men have over 16 years of experience, the highest paid employees in research and development fields are men. It is noted, however, that in the beginning salary scales ($16-27 k/yr) women outnumber men.

The April 16th 2016 Pedernales Earthquake and Instituto Geofisico efforts for improving seismic monitoring in Ecuador

NASA Astrophysics Data System (ADS)

Ruiz, M. C.; Alvarado, A. P.; Hernandez, S.; Singaucho, J. C.; Gabriela, P.; Landeureau, A.; Perrault, M.; Acero, W.; Viracucha, C.; Plain, M.; Yepes, H. A.; Palacios, P.; Aguilar, J.; Mothes, P. A.; Segovia, M.; Pacheco, D. A.; Vaca, S.

2016-12-01

On April 16th, 2016, Ecuador's coastal provinces were struck by a devastating earthquake with 7.8 Mw magnitude. This event caused the earthquake-related largest dead toll in Ecuador (663 fatalities) since 1987 inland event. It provoked also a widespread destruction of houses, hotels, hospitals, affecting economic activities. Damaged was very worthy in the city of Pedernales, one of the nearest localities to the epicenter. Rupture area extended about a 100 km from the southern limit marked by the aftershock area of the 1998, 7.1 Mw earthquake to its northern limit controlled by the Punta Galera-Mompiche seismic zone, which is one of the several elongated swarms oriented perpendicular to the trench that occurred since 2007. Historical accounts of the Ecuador Colombia subduction zone have few mentions of felt earthquakes in the XVIII and XIX century likely related to poor communication and urban settlements in this area. A cycle of noticeable earthquakes began in 1896, including the 1906 8.8 Mw event and three earthquakes with magnitudes larger than 7.7 in the period 1942-1979, that preceded the 2016 earthquake. The Instituto Geofiísico of the Escuela Politécnica Nacional (IGEPN) has been monitoring the coastal area through the National Seismic Network (RENSIG) since 30 years back and recently enhanced through SENASCYT and SENPLADES supported projects. International collaboration from Japanese JICA and French IRD also contributed to expand the network and implement research projects in the area. Nowadays, the RENSIG has 135 seismic stations including 105 broadband and 5 strong motion velocimeters. Processing performed by Seiscomp3 software allows an automatic distribution of seismic parameters. A joint cooperation between IGEPN, the Navy Oceanographic Institute and the National Department for Risk Management is in charge of tsunami monitoring.

Durable fiber optic sensor for gas temperature measurement in the hot section of turbine engines

NASA Astrophysics Data System (ADS)

Tregay, George W.; Calabrese, Paul R.; Finney, Mark J.; Stukey, K. B.

1994-10-01

An optical sensor system extends gas temperature measurement capability in turbine engines beyond the present generation of thermocouple technology. The sensing element which consists of a thermally emissive insert embedded inside a sapphire lightguide is capable of operating above the melting point of nickel-based super alloys. The emissive insert generates an optical signal as a function of temperature. Continued development has led to an optically averaged system by combining the optical signals from four individual sensing elements at a single detector assembly. The size of the signal processor module has been reduced to overall dimensions of 2 X 4 X 0.7 inches. The durability of the optical probe design has been evaluated in an electric-utility operated gas turbine under the sponsorship of the Electric Power Research Institute. The temperature probe was installed between the first stage rotor and second stage nozzle on a General Electric MS7001B turbine. The combined length of the ceramic support tube and sensing element reached 1.5 inches into the hot gas stream. A total of over 2000 hours has been accumulated at probe operation temperatures near 1600 degree(s)F. An optically averaged sensor system was designed to replace the existing four thermocouple probes on the upper half of a GE F404 aircraft turbine engine. The system was ground tested for 250 hours as part of GE Aircraft Engines IR&D Optical Engine Program. Subsequently, two flight sensor systems were shipped for use on the FOCSI (Fiber Optic Control System Integration) Program. The optical harnesses, each with four optical probes, measure the exhaust gas temperature in a GE F404 engine.

Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol.

PubMed

Borg, Bindi; Mihrshahi, Seema; Griffin, Mark; Chamnan, Chhoun; Laillou, Arnaud; Wieringa, Frank T

2017-09-06

The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food's acceptability to children and caregivers. This is a cluster-randomised, incomplete block, 4×4 crossover design with no blinding. It will take place in four sites in a community setting in periurban Phnom Penh. Healthy children aged 9-23 months (n=100) will eat each of four foods for 3 days at a time. The amount they consume will be measured, and at the end of each 3-day set, caregivers will assess how well their child liked the food. After 12 days, caregivers themselves will do a sensory test of the 4 foods and will rank them in terms of preference. Ethical clearance was received from the University of Queensland Medical Research Ethics Committee (2014001070) and from Cambodia's National Ethics Committee for Health Research (03/8 NECHR). ClinicalTrials.gov, identifier: LNS-CAMB-INFANTS; NCT02257437. Pre-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Radiation hardened microprocessor for small payloads

NASA Technical Reports Server (NTRS)

Shah, Ravi

1993-01-01

The RH-3000 program is developing a rad-hard space qualified 32-bit MIPS R-3000 RISC processor under the Naval Research Lab sponsorship. In addition, under IR&D Harris is developing RHC-3000 for embedded control applications where low cost and radiation tolerance are primary concerns. The development program leverages heavily from commercial development of the MIPS R-3000. The commercial R-3000 has a large installed user base and several foundry partners are currently producing a wide variety of R-3000 derivative products. One of the MIPS derivative products, the LR33000 from LSI Logic, was used as the basis for the design of the RH-3000 chipset. The RH-3000 chipset consists of three core chips and two support chips. The core chips include the CPU, which is the R-3000 integer unit and the FPA/MD chip pair, which performs the R-3010 floating point functions. The two support whips contain all the support functions required for fault tolerance support, real-time support, memory management, timers, and other functions. The Harris development effort had first passed silicon success in June, 1992 with the first rad-hard 32-bit RH-3000 CPU chip. The CPU device is 30 kgates, has a 508 mil by 503 mil die size and is fabricated at Harris Semiconductor on the rad-hard CMOS Silicon on Sapphire (SOS) process. The CPU device successfully passed tesing against 600,000 test vectors derived directly on the LSI/MIPS test suite and has been operational as a single board computer running C code for the past year. In addition, the RH-3000 program has developed the methodology for converting commercially developed designs utilizing logic synthesis techniques based on a combination of VHDK and schematic data bases.

Biomarker records and paleoenvironment of the central Arctic Ocean during Paleogene times

NASA Astrophysics Data System (ADS)

Weller, P.; Stein, R.

2007-12-01

During IODP Expedition 302 (Arctic Coring Expedition - ACEX), a more than 200 m thick sequence of Paleogene organic-carbon (OC)-rich (black shale-type) sediments has been drilled. Here, we present new biomarker data determined in ACEX sediment samples to decipher processes controlling OC accumulation and their paleo- environmental significance during periods of extreme global warmth and proposed increased freshwater discharge in the early Cenozoic. Specific source-related biomarkers including n-alkanes, fatty acids, isoprenoids, carotenoids, steranes/sterenes, hopanes/hopenes, hopanoic acids, aromatic terpenoids, benzohopanes, long- chain alkenones and organic sulfur compounds show a high variable of compounds, derived from marine, terrestrial and bacterial origin. Based on the biomarker data, the terrestrial OC supply was significantly enriched during the late Paleocene and part of the earliest Eocene, whereas n-alkanes and n-fatty acids in samples from the PETM and Elmo events as well as the middle Eocene indicate increased aquatic contributions. For the latter, an anoxic environment similar to the modern Black Sea, and moderate primary productivity are proposed. The occurrence of C37-alkenenones, which were first determined in the middle part of the Azolla Freshwater Event (about 49 Ma), suggests that significant amounts of the OC is of marine origin during in middle Eocene. During the Eocene, a prominant cooling and onset of first significant IRD deposition near 45.4 Ma were recorded in the terrigenous coarse fraction of the ACEX sequence, related to iceberg and/or sea-ice transport (K. St. John, Paleoceanography, in press). This cooling trend is also reflected in the alkenone SST, showing a temperature decrease of about 10°C between about 49 and 44 Ma.

Exploring Structures and Variability in the Pre-transitional Disk in HD 169142

NASA Astrophysics Data System (ADS)

Wagner, Kevin Robert; Sitko, Michael L.; Grady, Carol A.; Whitney, Barbara; Swearingen, Jeremy R.; Champney, Elizabeth H.; Johnson, Alexa N.; Warren, Chelsea C.; Russell, Ray W.; Schneider, Glenn; Momose, Muntake; Muto, Takayuki; Inoue, Akio K.; Lauroesch, James Thomas; Hornbeck, Jeremy; Brown, Alexander; Fukagawa, Misato; Currie, Thayne M.; Wisniewski, John P.; Woodgate, Bruce E.

2015-01-01

We present a theoretical modelling analysis of of the structures in the pre-transisitonal disk in HD 169142 using 3D Monte-Carlo radiative transfer simulation. The multi-epoch broadband spectral energy distribution (SED) exhibits clear evidence of changes to the inner (sub-AU) regions of the disk over a maximum timescale of 10 years with the additional constraint that the shadowing of the outer (>25 AU) disk is non-time-dependent. We find that changes to the inner dust rim (0.2 AU) cannot account for this behavior. Instead, we find that if the inner disk posses an optically thin body of small grains then changes to the outer edge of these structures may successfully reproduce the two states in the SED (analogous to what may be occurring due to accretion onto the central star or dynamical clearing by planets). Furthermore, we explore the density distributions of the outer disk structures as they are constrained by the SED and imaged surface brightness profiles, with the conclusion that a mid-plane density power law profile of r^{-2} and r^{-1} for the 35-70 AU and 70-250 AU regions, respectively, may reproduce the observations to the limit of our available complexity of structures within our modelling software. Finally, we find that a 0.3x density scaling of the 35-70 AU region reproduces the second gap imaged in the near-infrared and at 7 mm, strengthening the link to this structure being cleared by one or more planetary mass bodies.This work was supported by NASA ADAP grant NNX09AC73G, Hubble Space Telescope grant HST-GO-13032, the IR&D program at The Aerospace Corporation, and the University of Cincinnati Honors Program.

Example of activities of the MERCATOR-Océan Project : oil spill and yacht race

NASA Astrophysics Data System (ADS)

Toumazou, V.; Greiner, E.; Blanc, F.; Lellouche, J. M.; Nouel, L.

2003-04-01

MERCATOR-Ocean is the french group aiming at developing an operational capacity for global ocean analysis and forecasting monitoring, based on near-real-time assimilation of satellite and in situ ocean observations in three-dimensional ocean models. MERCATOR-Ocean is supported by the six major french agencies involved in oceanography : CNES (French Space Agency), CNRS (National Center for Scientific Research), IFREMER (French Institute of Research and Exploitation of the Sea), IRD (Research Institute for Development), Météo-France (French Meteorological Agency) and SHOM (Navy Hydrographic and Oceanographic Service) - with a strong engagement of their subsidiaries CERFACS (European Center for Research and Advanced Training in Scientific Computation) and CLS (Collecte Localisation Satellite) in the success of the project. Every week since January 17, 2001, MERCATOR provides the oceanographic community with a set of maps and data about the underlying variables of the ocean, such as velocity, salinity, temperature and sea level anomalies, which describe the ocean in all its dimensions, from instantaneous analysis to 2-week forecasts, from the sea surface to the sea floor. Since november 2002, MERCATOR-Ocean has been involved in two major events. Early november 2002, the project provided skippers of the Route du Rhum transatlantic yacht race with prevision of sea-surface currents. In the mean time, on Tuesday November 19, the oil tanker Prestige sank in the Atlantic off the Portuguese and Spanish coasts. Called upon from the outset, MERCATOR OCEAN began November 20 to provide analyses and forecasts for two weeks in the future for the state of the ocean in the area, both on the surface and at depth, to teams of specialists of the crisis unit coordinated by CEDRE. This talk details these recent activities and draws the main lines of MERCATOR-Ocean actuality and future.

Rip current related drowning deaths and rescues in Australia 2004-2011

NASA Astrophysics Data System (ADS)

Brighton, B.; Sherker, S.; Brander, R.; Thompson, M.; Bradstreet, A.

2013-04-01

Rip currents are a common hazard to beachgoers found on many beaches around the world, but it has proven difficult to accurately quantify the actual number of rip current related drowning deaths in many regions and countries. Consequently, reported estimates of rip current drowning can fluctuate considerably and are often based on anecdotal evidence. This study aims to quantify the incidence of rip current related drowning deaths and rescues in Australia from 2004 to 2011. A retrospective search was undertaken for fatal and non-fatal rip-related drowning incidents from Australia's National Coronial Information System (NCIS), Surf Life Saving Australia's (SLSA, 2005-2011) SurfGuard Incident Report Database (IRD), and Media Monitors for the period 1 July 2004 to 30 June 2011. In this time, rip currents were recorded as a factor in 142 fatalities of a total of 613 coastal drowning deaths (23.2%), an average of 21 per year. Rip currents were related to 44% of all beach-related drowning deaths and were involved in 57.4% of reported major rescues in Australian locations where rips occur. A comparison with international operational statistics over the same time period describes rip-related rescues as 53.7% of the total rescues in the US, 57.9% in the UK and 49.4% in New Zealand. The range 49-58% is much lower than 80-89% traditionally cited. The results reported are likely to underestimate the size of the rip current hazard, because we are limited by the completeness of data on rip-related events; however this is the most comprehensive estimate to date. Beach safety practitioners need improved data collection and standardized definitions across organisations. The collection of drowning data using consistent categories and the routine collection of rip current information will allow for more accurate global comparisons.

Abrupt aridities in the Levant-Sahel linked with solar activities

NASA Astrophysics Data System (ADS)

Stein, M.; Kushnir, Y.

2012-04-01

Observations of 19th and 20th century precipitation in the Dead Sea watershed region display a multidecadal, anti-phase relationship to North Atlantic (NAtl) sea surface temperature (SST) variability, such that when the NAtl is relatively cold, Jerusalem experiences higher than normal precipitation and vice versa. This association is underlined by a negative correlation to precipitation in the sub-Saharan Sahel and a positive correlation to precipitation in western North America, areas that are also affected by multidecadal NAtl SST variability. These observations are consistent with broad range of Holocene hydroclimatic fluctuations from the epochal, to the millennial and centennial time scales, as displayed by the Dead Sea and Sahelian lake levels and by direct and indirect proxy indicators of NAtl SSTs. On the epochal time scale, the gradual cooling of NAtl SSTs throughout the Holocene in response to precession-driven reduction of summer insolation is associated with previously well-studied wet-to-dry transition in the Sahel and with a general increase in Dead Sea lake levels from low stands after the Younger Dryas to higher stands in the mid- to late-Holocene. On the millennial and centennial time scales there is also evidence for an antiphase relationship between Holocene variations in the Dead Sea and Sahelian lake levels and with proxy indicators of NAtl SSTs. However, the records are punctuated by abrupt lake-level drops and extensive expansion of the desert belt at ~8.1, 5.7, 3.3 and 1.4 ka cal BP, which appear to be in-phase and which occur during previously documented abrupt major cooling events in the Northern Hemisphere. We link these cooling to solar activity variations that were identified in the North Atlantic IRD and cosmogenic isotopes records.

Use Of The Operational Air Quality Monitor (AQM) For In-Flight Water Testing Project

NASA Technical Reports Server (NTRS)

Macatangay, Ariel

2014-01-01

A primary requirement for manned spaceflight is Environmental Health which ensures air and water contaminants, acoustic profiles, microbial flora, and radiation exposures within the cabin are maintained to levels needed for crew health and for vehicle system functionality. The reliance on ground analyses of returned samples is a limitation in the current environmental monitoring strategy that will prevent future Exploration missions beyond low-Earth orbit. This proposal attempts to address this shortcoming by advancing in-flight analyses of water and air. Ground analysis of in-flight, air and water samples typically employ vapor-phase analysis by gas chromatography-mass spectrometry (GC-MS) to identify and quantify organic compounds present in the samples. We envision the use of newly-developed direct ionization approaches as the most viable avenue leading towards an integrated analytical platform for the monitoring of water, air, and, potentially bio-samples in the cabin environment. Development of an in-flight instrument capable of analyzing air and water samples would be the logical next step to meeting the environmental monitoring needs of Exploration missions. Currently, the Air Quality Monitor (AQM) on-board ISS provides this specific information for a number of target compounds in the air. However, there is a significant subset of common target compounds between air and water. Naturally, the following question arises, "Can the AQM be used for both air and water quality monitoring?" Previous directorate-level IR&D funding led to the development of a water sample introduction method for mass spectrometry using electrothermal vaporization (ETV). This project will focus on the integration of the ETV with a ground-based AQM. The capabilities of this integrated platform will be evaluated using a subset of toxicologically important compounds.

Calibration and application of the IP25 biomarker for Arctic sea ice reconstructions

NASA Astrophysics Data System (ADS)

Cabedo Sanz, P.; Navarro Rodriguez, A.; Belt, S. T.; Brown, T. A.; Knies, J.; Husum, K.; Giraudeau, J.; Andrews, J.

2012-04-01

The presence of the sea ice diatom biomarker IP25 in Arctic marine sediments has been used in previous studies as a proxy for past spring sea ice occurrence and as an indicator of wider palaeoenvironmental conditions for different regions of the Arctic over various timescales [e.g. 1, 3]. In addition, measurement of IP25 has also been applied as a sea ice origin tracer for studying the transfer of organic carbon through Arctic food-webs [2]. The current study focuses on three main areas: (1) In order to improve on the quantitative analytical aspects of IP25 based research, we present here the results of a large scale extraction, purification and identification procedure for IP25 from marine sediments. This has confirmed the structure of IP25 in sediments and enabled more robust quantitative measurements by gas chromatography - mass spectrometry (GC-MS) to be established. (2) Quantitative measurements of IP25 from a sediment core from Andfjord (continental shelf, Tromsø, Norway) have been determined for the period 6.3 to 14.3 ka BP. The results of this study add significant further information to that reported previously from other biomarker studies for this core (e.g. brassicasterol) [4]. (3) Analytical detection issues (GC-MS) regarding the occurrence of IP25 in other sub-Arctic regions (e.g. East Greenland - North Iceland area) will be presented and discussed with relation to other proxy data (e.g. IRD). Belt, S. T., Vare, L. L., Massé, G., Manners, H. R., Price, J. C., MacLachlan, S. E., Andrews, J. T. & Schmidt, S. (2010) 'Striking similarities in temporal changes to spring sea ice occurrence across the central Canadian Arctic Archipelago over the last 7000 years', Quaternary Science Reviews, 29 (25-26), pp. 3489-3504. Brown, T. A. & Belt, S. T. (2012) 'Identification of the sea ice diatom biomarker IP25 in Arctic benthic macrofauna: direct evidence for a sea ice diatom diet in Arctic heterotrophs', Polar Biology, 35, pp. 131-137. Müller, J., Massé, G., Stein, R. & Belt, S. T. (2009) 'Variability of sea-ice conditions in the Fram Strait over the past 30,000 years', Nature Geoscience, 2 (11), pp. 772-776. .Knies, J. (2005) 'Climate-induced changes in sedimentary regimes for organic matter supply on the continental shelf off northern Norway', Geochimica et Cosmochimica Acta, 69 (19), pp. 4631-4647.

Seismic Activity offshore Martinique and Dominique islands (Lesser Antilles subduction zone)

NASA Astrophysics Data System (ADS)

Ruiz Fernandez, Mario; Galve, Audrey; Monfret, Tony; Charvis, Philippe; Laigle, Mireille; Flueh, Ernst; Gallart, Josep; Hello, Yann

2010-05-01

In the framework of the European project Thales was Right, two seismic surveys (Sismantilles II and Obsantilles) were carried out to better constrain the lithospheric structure of the Lesser Antilles subduction zone, its seismic activity and to evaluate the associated seismic hazards. Sismantilles II experiment was conducted in January, 2007 onboard R/V Atalante (IFREMER). A total of 90 OBS belonging to Géoazur, INSU-CNRS and IFM-Geomar were deployed on a regular grid, offshore Antigua, Guadeloupe, Dominique and Martinique islands. During the active part of the survey, more than 2500 km of multichannel seismic profiles were shot along the grid lines. Then the OBS remained on the seafloor continuously recording for the seismic activity for approximately 4 months. On April 2007 Obsantilles experiment, carried out onboard R/V Antea (IRD), was focused on the recovery of those OBS and the redeployment of 28 instruments (Géoazur OBS) off Martinique and Dominica Islands for 4 additional months of continuous recording of the seismicity. This work focuses on the analysis of the seismological data recorded in the southern sector of the study area, offshore Martinique and Dominique. During the two recording periods, extending from January to the end of August 2007, more than 3300 seismic events were detected in this area. Approximately 1100 earthquakes had enough quality to be correctly located. Station corrections, obtained from multichannel seismic profiles, were introduced to each OBS to take in to account the sedimentary cover and better constrain the hypocentral determinations. Results show events located at shallower depths in the northern sector of the array, close to the Tiburon Ridge, where the seismic activity is mainly located between 20 to 40 km depth. In the southern sector, offshore Martinique, hypocenters become deeper, ranging to 60 km depth and dipping to the west. Focal solutions have also been obtained using the P wave polarities of the best azimuthally constrained earthquakes (Gap smaller than 90°). Focal mechanisms also reveal some differences between the northern and southern sector of the array. Whereas in the southern sector most of the analysed events show purely reverse fault solutions, in the northern area events present strike slip and normal fault solutions and could be related to intraplate deformation.

[The research of Valeriana amurensis seed germination characteristics].

PubMed

Liu, Juan; Yang, Chun-Rong; Jiang, Bo; Fang, Min; Du, Juan

2011-10-01

To study the effect of different treatments on the Valeriana amurensis seed germination rate. Used different chemical reagents and seed soakings on the routine germination test and the orthogonal test of the Valeriana amurensis seed, calculated the germination rate under different germination condition. Valeriana amurensis treated with different chemical reagends had different germination rate. The suitable immersion time could enhance Valeriana amurensis seed germination rate. Different treatment time, different disposal temperature, different germination temperature would have an impact on the Valeriana amurensis seed germination rate. In order to raise the Valeriana amurensis seed germination rate, use appropriate treatment on the seed before plant seeds; The seed growing must under suitable time and temperature.

Trend and variability in western and central Africa streamflow, and their relation to climate variability between 1950 and 2010

NASA Astrophysics Data System (ADS)

Sidibe, Moussa; Dieppois, Bastien; Mahé, Gil; Paturel, Jean-Emmanuel; Rouché, Nathalie; Amoussou, Ernest; Anifowose, Babatunde; Lawler, Damian

2017-04-01

Unprecedented drought episodes that struck western and central Africa between the late 1960s and 1980s. This triggered many studies investigating rainfall variability and its impacts on food production systems. However, most studies were focused at the catchment scale. In this study, we examine how rainfall variability has impacted on river flow at the subcontinental scale between 1950 and 2010, as well as the key large-scale controls on this relationship. For the first time, we establish a complete, gap-filled, monthly streamflow data set, which extends from 1950 to 2010, over the western and central African region. To achieve this, we used linear regression modelling across and between 600 flow gauging stations (see initial database information at http://www.hydrosciences.fr/sierem/index_en.htm). Streamflow trend and variability are then seasonally assessed at this subcontinental scale and compared to those observed in three different rainfall data sets (i.e. CRU TS3.24, GPCC V7, IRD-HSM). Long-term trends and variability in streamflow are mainly consistent with trends in rainfall. However, these relationships may have been moderated by: i) changes in land use; and ii) contributions from groundwater resources. In particular, we note that the recent post 1990s partial recovery in Sahel rainfall could have, at least partially, positively impacted river flows (e.g. the Senegal and Niger rivers). Using multi-temporal trend and continuous wavelet analysis, the time-evolution of western and central African river flows are analysed, and are all characterized by very strong decadal fluctuations, which can be interpreted as modulations in the baseflow. These decadal fluctuations, which are also significantly detected in rainfall, are likely related to large-scale sea-surface temperature (SST) anomaly patterns, such as the tropical Atlantic SST variability, the Atlantic Multidecadal Oscillation, the Interdecadal Pacific Oscillation and/or the Pacific Decadal Oscillation. Furthermore, hitherto-poorly understood hydroclimatic processes related to these teleconnections at decadal timescales will be examined in this study. Influences of the catchment properties (e.g. size, shape, vegetation and landuse cover, soil type, ground-water level, direction of stream flow across climate zones) on these decadal fluctuations in river flows will also be assessed. This study therefore aims to improve the ability of current regional and global climate models to simulate such ranges of variability, to significantly improve regional hydroclimate understanding, as a means for improving the development of future scenarios for water resources in western and central Africa.

Rate My Information Systems Professor: Exploring the Factors That Influence Student Ratings

ERIC Educational Resources Information Center

Sena, Mark; Crable, Elaine

2017-01-01

Based on 820 entries on Ratemyprofessors.com, we explore whether information systems course ratings differ from those in marketing or management courses, whether lower level course ratings differ from those in senior or graduate level courses, whether course ratings differ between genders, and whether perceived course difficulty impacts course…

Glacimarine sedimentation in Petermann Fjord and Nares Strait, NW Greenland

NASA Astrophysics Data System (ADS)

Hogan, Kelly; Jakobsson, Martin; Mayer, Larry; Mix, Alan; Nielsen, Tove; Kamla, Elina; Reilly, Brendan; Heirman, Katrina An; Stranne, Christian; Mohammed, Rezwan; Eriksson, Bjorn; Jerram, Kevin

2017-04-01

Here we build on preliminary results from 6500 line-km of high-resolution chirp sub-bottom profiles (2-7 kHz) acquired in Petermann Fjord and Nares Strait during the Petermann 2015 Expedition of the Swedish icebreaker Oden. We map the unlithified sediment cover in Peterman Fjord, which consists of up to 3 conformable "drape" units and calculate volumes of this assumed "post-glacial" fill. In Nares Strait we have mapped sediment volumes in local basins just beyond the sill at the Petermann Fjord-mouth: do these sediments represent material flushed out from the grounding zone of Petermann Glacier when it was grounded at the sill? In this vein, and interestingly, some of the thickest sediments that we observe are found close to a grounding-zone wedge (GZW) in Nares Strait that represents a former grounding zone of ice retreating southwards through the strait. We also map conformable units across Nares Strait and consider the similarities between these and the sediment units in the fjord. Do the strong reflections between the units represent the same climatic, oceanographic or process-shift both inside and outside the fjord? We also aim to tie our new acoustic stratigraphy to sediment-core data (lithofacies, dates) and, therefore, to comment on the age of the mapped sediment units and present ideas on the glacimarine flux of material to the Petermann-Nares system. Primary sediment delivery to the seafloor in this environment is thought to be predominantly through sedimentation from meltwater plumes but also of iceberg-rafted debris (IRD). However, sediment redeposition by slope failures on a variety of scales also occurs and has focussed sediments into discrete basins where the seafloor is rugged. This work - which aims to relate past sediment, meltwater and iceberg fluxes to changes in climate - will help us to identify how the system has responded to a past global warming event, namely the last deglaciation. This is particularly relevant in light of the recent thinning and acceleration of NW Greenland's marine-terminating outlet glaciers.

Late Holocene glacial history of Petermann Fjord, Northwest Greenland: Non-destructive CT, XRF, and magnetic results from OD1507 sediment cores

NASA Astrophysics Data System (ADS)

Reilly, B. T.; Stoner, J. S.; Mix, A. C.; Jakobsson, M.; Jennings, A. E.; Walczak, M.; Dyke, L. M.; Cheseby, M.; Albert, S. W.; Wiest, J.

2016-12-01

An international and interdisciplinary expedition to Nares Strait and Petermann Fjord, Northwest Greenland, onboard the Swedish Icebreaker Oden July-September 2015 (OD1507) sought to understand the Holocene history of the Petermann glacial system among other research objectives. Petermann Glacier, which terminates as a floating ice-tongue in Petermann Fjord, is thought to be especially sensitive to ice-ocean interactions. While limited historical observations dating back to 1876 suggest the Petermann Ice Tongue extends about 70-90 km from the grounding-line, large calving events in 2010 and 2012 reduced the ice-tongue extent to about 45 km from the grounding-line. A suite of 14 marine sediment cores recovered a range of glacio-marine facies that form an along fjord (15-80 km from the grounding-line) and an across fjord depth (473-1041 meters water depth) transect. CT scans clearly identify four primary fjord facies, including bioturbated, IRD-rich, laminated and mud with stratified graded sand layers. The latter of these occurs near the modern grounding-line. Additionally, a new MATLAB routine is used to quantify clasts >2 mm in size from the CT scans. XRF sediment geochemical changes mirror magnetic mineral concentrations and are driven by varying contribution of Ca-rich and Ca-poor sources, which we interpret as a reflection of the mixing of the local carbonate rocks and crystalline basement excavated by the ice sheet. Initial paleomagnetic results isolate a strong and stable characteristic remanent magnetization which show remarkable similarity to paleosecular variation (PSV) recorded in nearby mid-late Holocene varved lakes on Ellesmere Island. This non-destructive dataset provides robust correlations, indicating a coherent and dynamic record of changes in the Petermann glacial system during the late Holocene, including evidence for a significant grounding-line retreat followed by the growth and relative paleo-extent of the modern Petermann Ice Tongue.

Molecular cloning and characterization of a type 3 iodothyronine deiodinase in the pine snake Pituophis deppei.

PubMed

Villalobos, Patricia; Orozco, Aurea; Valverde-R, Carlos

2010-11-01

The three distinct but related isotypes of the iodothyronine deiodinase family: D1, D2, and D3, have been amply studied in vertebrate homeotherms and to a lesser extent in ectotherms, particularly in reptiles. Here, we report the molecular and kinetic characteristics of both the native and the recombinant hepatic D3 from the pine snake Pituophis deppei (PdD3). The complete PdD3 cDNA (1680 bp) encodes a protein of 287 amino acids (aa), which is the longest type 3 deiodinase so far cloned. PdD3 shares 78% identity with chicken and 71% with its other orthologs. Interestingly, the hinge domain in D3s, including PdD3, is rich in proline. This structural feature is shared with D1s, the other inner-ring deiodinases, and deserves further study. The kinetic characteristics of both native and recombinant PdD3 were similar to those reported for D3 in other vertebrates. True K(m) values for T(3) IRD were 9 and 11 nM for native and recombinant PdD3, respectively. Both exhibited a requirement for a high concentration of cofactor (40 mM DTT), insensitivity to inhibition by PTU (>2 mM), and bisubstrate, sequential-type reaction kinetics. In summary, the present data demonstrate that the liver of the adult pine snake P. deppei expresses D3. Furthermore, this is the first report of the cloning and expression of a reptilian D3 cDNA. The finding of hepatic D3 expression in the adult pine snake P. deppei is consistent with results in adult piscine species in which the dietary T(3) content seems to regulate liver deiodinase expression. Thus, our present results support the proposal that hepatic D3 in adult vertebrates plays a sentinel role in avoiding an inappropriate overload of exogenous T(3) secondary to feeding in those species that devour the whole prey. Copyright © 2010 Elsevier Inc. All rights reserved.

Magnetomineralogical Characterization of Heinrich Events Preserved on Turbiditic Sediments From the Galicia Bank (NW Iberian Margin)

NASA Astrophysics Data System (ADS)

Coimbra, R.; Rey, D.; Mohamed, K.; Vilas, F.; Frederichs, T.

2007-12-01

Abyssal marine environments combine the ideal conditions for recording the climatic instability occurred during the last glacial period. However, on a more dynamic zone, such as the Galicia Bank slope, the turbiditic activity may compromise the fidelity of a given record. In this context, we will show how very detailed magnetic measurements make possible the detection and characterization of distinct climatic events in these environments, such as the Heinrich events H1 to H3 described in this paper. The study area is located on the south-western flank of the Galicia Bank, at depths ranging from 3363 to 4171 meters. It is influenced by the Lower North Atlantic Deep Water (LNADW) and Antarctica Bottom Water (AABW) deep currents that flow northwards as a result of thermohaline equilibrium. Three gravity cores of around 3 m long and representative of the main sedimentary environments in the area (fault scarp; turbidite lobe and interlobe depression) were selected for detail magnetic analysis. Measurements at room (magnetic susceptibility, ARM, hysteresis) and low temperature (susceptibility and SIRM) revealed the occurrence of magnetic-enriched laminae within the magnitude range documented for Heinrich events recorded in sediment of the abyssal plain bordering the Iberian continental margin. The formation of loops in the ARM-100 vs. susceptibility plots highlighted the typical increase in magnetic grain size that characterizes Heinrich sediments at latitudes inside the Rudimann Belt. Recognition of IRD layers in very detrital-diluted horizons was possible after the evaluation of magnetic domain state. Low temperature measurements were also useful to clarify on the mineralogy and grain size of this ice rafted particles, which proved to be stoichiometric magnetite. This was supported by the occurrence of a clear Verwey transition at 120K. The significant loss of total remanence after a complete SIRM-300K cycle in these horizons indicated the presence of larger grain sizes, when compared to other samples studied along the cores.

Reconstruction of the extent and variability of late Quaternary ice sheets and Arctic sea ice: Insights from new mineralogical and geochemical proxy records

NASA Astrophysics Data System (ADS)

Stein, R. H.; Niessen, F.; Fahl, K.; Forwick, M.; Kudriavtseva, A.; Ponomarenko, E.; Prim, A. K.; Quatmann-Hense, A.; Spielhagen, R. F.; Zou, H.

2016-12-01

The Arctic Ocean and surrounding continents are key areas within the Earth system and very sensitive to present and past climate change. In this context, the timing and extent of circum-Arctic ice sheets and its interaction with oceanic and sea-ice dynamics are major interest and focus of international research. New sediment cores recovered during the Polarstern Expeditions PS87 (Lomonosov Ridge/2014) and PS93.1 (Fram Strait/2015) together with several sediment cores available from previous Polarstern expeditions allow to carry out a detailed sedimentological and geochemical study that may help to unravel the changes in Arctic sea ice and circum-Arctic ice sheets during late Quaternary times. Our new data include biomarkers indicative for past sea-ice extent, phytoplankton productivity and terrigenous input as well as grain size, physical property, XRD and XRF data indicative for sources and pathways of terrigenous sediments (ice-rafted debris/IRD) related to glaciations in Eurasia, East Siberia, Canada and Greenland. Here, we present examples from selected sediment cores that give new insights into the timing and extent of sea ice and glaciations during MIS 6 to MIS 2. To highlight one example: SE-NW oriented, streamlined landforms have been mapped on top of the southern Lomonosov Ridge (LR) at water depths between 800 and 1000 m over long distances during Polarstern Expedition PS87, interpreted to be glacial lineations that formed beneath grounded ice sheets and ice streams. The orientations of the lineations identified are similar to those on the East Siberian continental margin, suggesting an East Siberian Chukchi Ice Sheet extended far to the north on LR during times of extreme Quaternary glaciations. Based on our new biomarker records from Core PS2757 (located on LR near 81°N) indicating a MIS 6 ice-edge situation with some open-water phytoplankton productivity, the glacial erosional event should have been older than MIS 6 (e.g., MIS 12?).

3D Crustal Structure of the North-Ligurian Margin from Refraction Tomography S. Simon (1), J.-X. Dessa (1), M.-O. Beslier (1), A. Deschamps (1), N. Béthoux (1), S. Solarino (2), E. Eva (2), F. Sage (1), G. Ferretti (3), C. Eva (3), M. Lelièvre (1), and the GROSMarin Team (1)UNS/UPMC/OCA/INSU-CNRS/IRD, Villefranche-sur-Mer, France (ssimon@geoazur.obs-vlfr.fr), (2)INGV/Dip.Te.Ris, Genova, Italia (3) Univ. Genova/Dip.Te.Ris, Genova, Italia

NASA Astrophysics Data System (ADS)

Simon, S.; Dessa, J.; Beslier, M.; Deschamps, A.; Béthoux, N.; Solarino, S.; Eva, E.; Ferretti, G.; Eva, C.; Lelievre, M.

2010-12-01

The GROSMarin experiment, held in 2008, investigates the structures of the seismically active North Ligurian rifted margin. An array of 21 Ocean Bottom Seismometers was deployed offshore a region spanning from Nice to Imperia and recorded seismic refraction shots as well as microseismicity for a duration of more than 5 months. It was extended onland by both the regional French and Italian seismic networks and 13 mobile stations that provided an even density of acquisition on- and offshore. With this programme, we aim at characterizing the main structures of this singular margin and adjacent atypical oceanic crust and thick Alpine foreland. We also seek to detect and locate microseismic events that occur regularly, mostly offshore, and that herald rare large events such as the destructive 1887 Imperia earthquake (Mw 6.5) which is the greatest seismic event in the area since at least four hundred years, and whose source and associated tectonics remain poorly understood. We present and discuss some results of our active first arrival travel time tomography that covers the margin and coastal zone and includes a total of ~185,000 picks. The transition from oceanic to continental domains is clearly evidenced as well as an intermediate zone wherein anomalously high velocities are found at the base of the crust. Velocity structures are not found to evidence significant variations along strike and locally fit some published results of 1D logs.

PREVIMER : Meteorological inputs and outputs

NASA Astrophysics Data System (ADS)

Ravenel, H.; Lecornu, F.; Kerléguer, L.

2009-09-01

PREVIMER is a pre-operational system aiming to provide a wide range of users, from private individuals to professionals, with short-term forecasts about the coastal environment along the French coastlines bordering the English Channel, the Atlantic Ocean, and the Mediterranean Sea. Observation data and digital modelling tools first provide 48-hour (probably 96-hour by summer 2009) forecasts of sea states, currents, sea water levels and temperatures. The follow-up of an increasing number of biological parameters will, in time, complete this overview of coastal environment. Working in partnership with the French Naval Hydrographic and Oceanographic Service (Service Hydrographique et Océanographique de la Marine, SHOM), the French National Weather Service (Météo-France), the French public science and technology research institute (Institut de Recherche pour le Développement, IRD), the European Institute of Marine Studies (Institut Universitaire Européen de la Mer, IUEM) and many others, IFREMER (the French public institute fo marine research) is supplying the technologies needed to ensure this pertinent information, available daily on Internet at http://www.previmer.org, and stored at the Operational Coastal Oceanographic Data Centre. Since 2006, PREVIMER publishes the results of demonstrators assigned to limited geographic areas and to specific applications. This system remains experimental. The following topics are covered : Hydrodynamic circulation, sea states, follow-up of passive tracers, conservative or non-conservative (specifically of microbiological origin), biogeochemical state, primary production. Lastly, PREVIMER provides researchers and R&D departments with modelling tools and access to the database, in which the observation data and the modelling results are stored, to undertake environmental studies on new sites. The communication will focus on meteorological inputs to and outputs from PREVIMER. It will draw the lessons from almost 3 years during which the system has been operational almost everyday and propose perspectives in terms of technical improvements and possible business models.

The Database Query Support Processor (QSP)

NASA Technical Reports Server (NTRS)

1993-01-01

The number and diversity of databases available to users continues to increase dramatically. Currently, the trend is towards decentralized, client server architectures that (on the surface) are less expensive to acquire, operate, and maintain than information architectures based on centralized, monolithic mainframes. The database query support processor (QSP) effort evaluates the performance of a network level, heterogeneous database access capability. Air Force Material Command's Rome Laboratory has developed an approach, based on ANSI standard X3.138 - 1988, 'The Information Resource Dictionary System (IRDS)' to seamless access to heterogeneous databases based on extensions to data dictionary technology. To successfully query a decentralized information system, users must know what data are available from which source, or have the knowledge and system privileges necessary to find out this information. Privacy and security considerations prohibit free and open access to every information system in every network. Even in completely open systems, time required to locate relevant data (in systems of any appreciable size) would be better spent analyzing the data, assuming the original question was not forgotten. Extensions to data dictionary technology have the potential to more fully automate the search and retrieval for relevant data in a decentralized environment. Substantial amounts of time and money could be saved by not having to teach users what data resides in which systems and how to access each of those systems. Information describing data and how to get it could be removed from the application and placed in a dedicated repository where it belongs. The result simplified applications that are less brittle and less expensive to build and maintain. Software technology providing the required functionality is off the shelf. The key difficulty is in defining the metadata required to support the process. The database query support processor effort will provide quantitative data on the amount of effort required to implement an extended data dictionary at the network level, add new systems, adapt to changing user needs, and provide sound estimates on operations and maintenance costs and savings.

Remote Correlation of Paleoceanographic Events in the Northern Parts of Bering and Barents Seas during the Termination I and Early Holocene

NASA Astrophysics Data System (ADS)

Ivanova, E. V.; Ovsepyan, E.; Murdmaa, I.; de Vernal, A.; Risebrobakken, B.; Seitkalieva, E.; Radionova, E.; Alekhina, G.

2014-12-01

The Barents and Bering seas are closely linked to the High Arctic and to the THC by marine gateways as well as by land-sea and ocean-atmosphere interactions. Our multi-proxy time series demonstrate that these remote seas exhibited dramatic changes during the deglaciation through a succession of global and regional paleoceanographic events including the beginning of Termination I (BT1), Heinrich-1 or Oldest Dryas (OD), Bølling-Allerød (B/A), Younger Dryas (YD) and early Holocene (EH). In the NW Barents Sea, the increased subsurface-to-bottom Atlantic water inflow via the Kvitøya-Erik Eriksen trough (cores S 2519 and S 2528) is inferred at the late OD, late B/A and late YD/EH transition. These events are generally coupled with the strengthened AMOC. A remarkable sea surface warming and sea ice retreat are documented at ~ 13 ka BP. Surface warming and strong Atlantic water inflow were followed by intense iceberg calving in the Erik Eriksen Trough as indicated by the high IRD content of Core S-2519. The rock fragments are unsorted and mainly angular suggesting their ice-rafted (likely iceberg-rafted) origin. Svalbard glaciers apparently derived the material dominated by black schistous mudstones, hard limestones with coral remains, fine-grained sandstones from nearby islands, and icebergs spread it in the Kvitøya-Erik Eriksen Trough during the early deglaciation. The ice rafted coarse terrigenous material supply during the BT1 is also suggested for the NW Bering Sea. In the NW Pacific, NW Bering Sea and Sea of Okhotsk, surface bioproductivity peaked at B/A and EH mainly due to the global warming, enhanced nutrient supply by surface currents from the flooded northeastern shelf, intensified vertical mixing and water exchange through the opened straits. Oxygen-depleted bottom water at intermediate depths characterized several locations including the NW Bering Sea (Core SO201-2-85KL).

Searching for Last Glacial Deep-Sea Polar Carbonates in the Ross Sea Continental slope and Their Relevance to Chronological Constraints

NASA Astrophysics Data System (ADS)

Brambati, A.; Bonaccorsi, R.; Quaia, T.; Busetti, M.

2003-12-01

Ice-proximal glacial marine sediments from the Antarctic continental margin retain ice rafting events as proxy record for change in the volume and extension of the Antarctic ice sheet throughout glacial-interglacial cycles. However, the sedimentary sequences from the Ross Sea continental margin remain relatively poorly understood and most research has been focused mainly on continental shelf sequences during the last past decades. We present a data set (i.e., X-ray lithology, Multi Sensor Core Logger physical data, and preservation of biogenic carbonates), obtained from six deep-sea cores (1991-1999 Italian Antarctic Research Programme, PNRA - Summer cruises). Specifically, the cores were collected from a) the central Eastern sector (i.e., Core ANTA95-89C, depth: 2056 m, length: 401 cm and Core ANTA99-c22, depth: 2650 m, length: 851 cm); b) the central Western sector (i.e., Core ANTA99-c23; water depth: 2158 m, length: 548 cm; and ANTA99-c24, water depth: 2750 m, length: 811 cm); and c) the North Western sector (i.e., Core ANTA91-08C, and ANTA91-02C) of the Ross Sea Continental slope. Well-preserved calcareous foraminifers (N. pachyderma, sx) in coarse-grained IRD materials sparsely occur and/or are concentrated in discrete layers (i.e., up to 22 cm-thick) of at least three cores (i.e., Cores ANTA91-08, ANTA91-02, and ANTA95-89C, e.g., at 217-238 cm-depth). Some carbonate layers were deposited during a period of time bracketing Stage3/Stage2. In Core 89C foraminifers are associated to multiple ice rafting episodes and likely occurred with oceanographic changes in the properties of slope water masses. The search of well-preserved, in situ-deposited, polar carbonates is demanded for a reliable C-14 AMS dating of late Pleistocene events in the Ross Sea.

Greenhouse to Icehouse Antarctic Paleoclimate and Ice History from George V Land and Adélie Land Shelf Sediments

NASA Astrophysics Data System (ADS)

Williams, T.; Escutia, C.; De Santis, L.; O'Brien, P.; Pekar, S. F.; Brinkhuis, H.; Domack, E. W.

2013-12-01

Along the George V and Adélie Land continental shelf of East Antarctica, shallowly-buried strata contain a record of Antarctica's climate and ice history from the lush forests of the Eocene greenhouse to the dynamic ice sheet margins of the Neogene. Short piston cores and dredges have recovered Early Cretaceous and Eocene organic-rich sediment at the seabed, and in 2010, IODP Expedition 318 recovered earliest Oligocene and early Pliocene subglacial and proglacial diamictites. However, challenging ice and drilling conditions from the JOIDES Resolution on the shelf resulted in poor core recovery and sites had to be abandoned before the stratigraphic targets could be reached. Therefore, in a new IODP drilling proposal submitted earlier this year, we propose to use the MeBo sea bed drill for improved core recovery and easier access to the shelf, and drill a stratigraphic transect of shallow (~80m) holes. To investigate the evolution of the Antarctic ice sheet in this sector, we target strata above and below regional erosional and downlap surfaces to date and characterize major episodes of ice sheet advance and retreat. These direct records of ice extent on the shelf can be set in the context of Southern Ocean records of temperature, ice-rafted debris (IRD) and latitudinal fluctuations of the opal belt, and hence we can relate ice sheet evolution to paleoclimate conditions. Targets include possible late Eocene precursor glaciations, the Eocene/Oligocene boundary erosion surface, Oligocene and Miocene ice extents, and ice margin fluctuations in the Pliocene. At the Cretaceous and Eocene proposed sites, marine and terrestrial temperature proxies and palynological records will provide information on high-latitude paleoenvironments and pole-equator temperature gradients. Here we present existing data from the area and the proposed new drill sites. The ice and climate history of the George V and Adélie Land margin can provide warm-world scenarios to help understand ice sheet instability in analogous future warm climates.

Direct Energy Conversion for Nuclear Propulsion at Low Specific Mass

NASA Technical Reports Server (NTRS)

Scott, John H.

2014-01-01

The project will continue the FY13 JSC IR&D (October-2012 to September-2013) effort in Travelling Wave Direct Energy Conversion (TWDEC) in order to demonstrate its potential as the core of a high potential, game-changing, in-space propulsion technology. The TWDEC concept converts particle beam energy into radio frequency (RF) alternating current electrical power, such as can be used to heat the propellant in a plasma thruster. In a more advanced concept (explored in the Phase 1 NIAC project), the TWDEC could also be utilized to condition the particle beam such that it may transfer directed kinetic energy to a target propellant plasma for the purpose of increasing thrust and optimizing the specific impulse. The overall scope of the FY13 first-year effort was to build on both the 2012 Phase 1 NIAC research and the analysis and test results produced by Japanese researchers over the past twenty years to assess the potential for spacecraft propulsion applications. The primary objective of the FY13 effort was to create particle-in-cell computer simulations of a TWDEC. Other objectives included construction of a breadboard TWDEC test article, preliminary test calibration of the simulations, and construction of first order power system models to feed into mission architecture analyses with COPERNICUS tools. Due to funding cuts resulting from the FY13 sequestration, only the computer simulations and assembly of the breadboard test article were completed. The simulations, however, are of unprecedented flexibility and precision and were presented at the 2013 AIAA Joint Propulsion Conference. Also, the assembled test article will provide an ion current density two orders of magnitude above that available in previous Japanese experiments, thus enabling the first direct measurements of power generation from a TWDEC for FY14. The proposed FY14 effort will use the test article for experimental validation of the computer simulations and thus complete to a greater fidelity the mission analysis products originally conceived for FY13.

Peru Subduction Zone Seismic Experiment (PeruSZE): Preliminary Results From a Seismic Network Between Mollendo and Lake Titicaca, Peru.

NASA Astrophysics Data System (ADS)

Guy, R.; Stubailo, I.; Skinner, S.; Phillips, K.; Foote, E.; Lukac, M.; Aguilar, V.; Tavera, H.; Audin, L.; Husker, A.; Clayton, R.; Davis, P. M.

2008-12-01

This work describes preliminary results from a 50 station broadband seismic network recently installed from the coast to the high Andes in Peru. UCLA's Center for Embedded Network Sensing (CENS) and Caltech's Tectonic Observatory are collaborating with the IRD (French L'Institut de Recherche pour le Developpement) and the Institute of Geophysics, in Lima Peru in a broadband seismic experiment that will study the transition from steep to shallow slab subduction. The currently installed line has stations located above the steep subduction zone at a spacing of about 6 km. In 2009 we plan to install a line of 50 stations north from this line along the crest of the Andes, crossing the transition from steep to shallow subduction. A further line from the end of that line back to the coast, completing a U shaped array, is in the planning phase. The network is wirelessly linked using multi-hop network software designed by computer scientists in CENS in which data is transmitted from station to station, and collected at Internet drops, from where it is transmitted over the Internet to CENS each night. The instrument installation in Peru is almost finished and we have been receiving data daily from 10 stations (out of total 50) since June 2008. The rest are recording on-site while the RF network is being completed. The software system provides dynamic link quality based routing, reliable data delivery, and a disruption tolerant shell interface for managing the system from UCLA without the need to travel to Peru. The near real-time data delivery also allows immediate detection of any problems at the sites. We are building a seismic data and GPS quality control toolset that would greatly minimize the station's downtime by alerting the users of any possible problems.

The relation between saliva flow after different stimulations and the perception of flavor and texture attributes in custard desserts.

PubMed

Engelen, Lina; de Wijk, Rene A; Prinz, Jon F; van der Bilt, Andries; Bosman, Frits

2003-01-01

Salivary flow rates were measured at rest and after three types of stimulation; odor, Parafilm chewing, and citric acid. The highest flow rate was elicited by citric acid followed by Parafilm and odor, while the lowest flow rate was unstimulated. In order to investigate whether and how the amount of saliva a subject produces influences the sensory ratings, the four types of salivary flow rates were correlated with sensory ratings of three different types of vanilla custard dessert. No significant correlation could be found between any of the salivary flow rates and the sensory ratings. A subject with a larger saliva flow rate during eating did not rate the foods differently from a subject with less saliva flow. The same pattern was seen for all types of stimulation. This finding could indicate that subjects are used to their respective amounts of saliva to such a degree that the differences in sensory ratings between subjects cannot be explained by the interindividual difference in saliva flow rate.

Spatial variation in senescence rates in a bird metapopulation.

PubMed

Holand, H; Kvalnes, T; Gamelon, M; Tufto, J; Jensen, H; Pärn, H; Ringsby, T H; Sæther, B-E

2016-07-01

Investigating factors which affect the decline in survival with age, i.e. actuarial senescence, is important in order to understand how demographic rates vary in wild populations. Although the evidence for the occurrence of actuarial senescence in wild populations is growing, very few studies have compared actuarial senescence rates between wild populations of the same species. We used data from a long-time study of demography of house sparrows (Passer domesticus) to investigate differences in rates of actuarial senescence between habitats and sub-populations. We also investigated whether rates of actuarial senescence differed between males and females. We found that rates of actuarial senescence showed large spatial variation. We also found that the onset of actuarial senescence varied between sub-populations. However, these differences were not significantly explained by a general difference in habitat type. We also found no significant difference in actuarial senescence rates between males and females. This study shows that senescence rates in natural populations may vary significantly between sub-populations and that failing to account for such differences may give a biased estimate of senescence rates of a species.

Explaining large mortality differences between adjacent counties: a cross-sectional study.

PubMed

Schootman, M; Chien, L; Yun, S; Pruitt, S L

2016-08-02

Extensive geographic variation in adverse health outcomes exists, but global measures ignore differences between adjacent geographic areas, which often have very different mortality rates. We describe a novel application of advanced spatial analysis to 1) examine the extent of differences in mortality rates between adjacent counties, 2) describe differences in risk factors between adjacent counties, and 3) determine if differences in risk factors account for the differences in mortality rates between adjacent counties. We conducted a cross-sectional study in Missouri, USA with 2005-2009 age-adjusted all-cause mortality rate as the outcome and county-level explanatory variables from a 2007 population-based survey. We used a multi-level Gaussian model and a full Bayesian approach to analyze the difference in risk factors relative to the difference in mortality rates between adjacent counties. The average mean difference in the age-adjusted mortality rate between any two adjacent counties was -3.27 (standard deviation = 95.5) per 100,000 population (maximum = 258.80). Six variables were associated with mortality differences: inability to obtain medical care because of cost (β = 2.6), hospital discharge rate (β = 1.03), prevalence of fair/poor health (β = 2.93), and hypertension (β = 4.75) and poverty prevalence (β = 6.08). Examining differences in mortality rates and associated risk factors between adjacent counties provides additional insight for future interventions to reduce geographic disparities.

[Research about effect of spray drying conditions on hygroscopicity of spray dry powder of gubi compound's water extract and its mechanism].

PubMed

Zong, Jie; Shao, Qi; Zhang, Hong-Qing; Pan, Yong-Lan; Zhu, Hua-Xu; Guo, Li-Wei

2014-02-01

To investigate moisture content and hygroscopicity of spray dry powder of Gubi compound's water extract obtained at different spray drying conditions and laying a foundation for spray drying process of Chinese herbal compound preparation. In the paper, on the basis of single-factor experiments, the author choose inlet temperature, liquid density, feed rate, air flow rate as investigated factors. The experimental absorption rate-time curve and scanning electron microscopy results showed that under different spray drying conditions the spray-dried powders have different morphology and different adsorption process. At different spray-dried conditions, the morphology and water content of the powder is different, these differences lead to differences in the adsorption process, at the appropriate inlet temperature and feed rate with a higher sample density and lower air flow rate, in the experimental system the optimum conditions is inlet temperature of 150 degrees C, feed density of 1.05 g x mL(-1), feed rate of 20 mL x min(-1) air flow rate of 30 m3 x h(-1).

Denitrification and Nitrogen Fixation in Alaskan Continental Shelf Sediments

PubMed Central

Haines, John R.; Atlas, Ronald M.; Griffiths, Robert P.; Morita, Richard Y.

1981-01-01

Rates of nitrogen fixation and denitrification were measured in Alaskan continental shelf sediments. In some regions, rates of nitrogen fixation and denitrification appeared to be equal; in other areas, rates were significantly different. Potential rates of denitrification were found to be limited primarily by the available nitrate substrate. Major regional differences in rates of denitrification were not statistically significant, but significant differences were found for nitrogen fixation rates in different regions of the Alaskan continental shelf. Estimated net losses of nitrogen from Bering Sea sediments were calculated as 1.8 × 1012 g of N/yr. Experimental exposure of continental shelf sediments to petroleum hydrocarbons reduced rates of nitrogen fixation and denitrification in some cases but not others. Long-term exposure was necessary before a reduction in nitrogen fixation rates was observed; unamended rates of denitrification but not potential denitrification rates (NO3− added) were depressed after exposure to hydrocarbons. PMID:16345716

Age-Related Differences in Speech Rate Perception Do Not Necessarily Entail Age-Related Differences in Speech Rate Use

ERIC Educational Resources Information Center

Heffner, Christopher C.; Newman, Rochelle S.; Dilley, Laura C.; Idsardi, William J.

2015-01-01

Purpose: A new literature has suggested that speech rate can influence the parsing of words quite strongly in speech. The purpose of this study was to investigate differences between younger adults and older adults in the use of context speech rate in word segmentation, given that older adults perceive timing information differently from younger…

Rating Scale Impact on EFL Essay Marking: A Mixed-Method Study

ERIC Educational Resources Information Center

Barkaoui, Khaled

2007-01-01

Educators often have to choose among different types of rating scales to assess second-language (L2) writing performance. There is little research, however, on how different rating scales affect rater performance. This study employed a mixed-method approach to investigate the effects of two different rating scales on EFL essay scores, rating…

34 CFR 222.68 - What tax rates does the Secretary use if two or more different classifications of real property...

Code of Federal Regulations, 2011 CFR

2011-07-01

... different classifications of real property are taxed at different rates? 222.68 Section 222.68 Education... different classifications of real property are taxed at different rates? If the real property of an LEA and its generally comparable LEAs consists of two or more classifications of real property taxed at...

Correlations of nucleotide substitution rates and base composition of mammalian coding sequences with protein structure.

PubMed

Chiusano, M L; D'Onofrio, G; Alvarez-Valin, F; Jabbari, K; Colonna, G; Bernardi, G

1999-09-30

We investigated the relationships between the nucleotide substitution rates and the predicted secondary structures in the three states representation (alpha-helix, beta-sheet, and coil). The analysis was carried out on 34 alignments, each of which comprised sequences belonging to at least four different mammalian orders. The rates of synonymous substitution were found to be significantly different in regions predicted to be alpha-helix, beta-sheet, or coil. Likewise, the nonsynonymous rates also differ, although expectedly at a lower extent, in the three types of secondary structure, suggesting that different selective constraints associated with the different structures are affecting in a similar way the synonymous and nonsynonymous rates. Moreover, the base composition of the third codon positions is different in coding sequence regions corresponding to different secondary structures of proteins.

An algorithm for the kinetics of tire pyrolysis under different heating rates.

PubMed

Quek, Augustine; Balasubramanian, Rajashekhar

2009-07-15

Tires exhibit different kinetic behaviors when pyrolyzed under different heating rates. A new algorithm has been developed to investigate pyrolysis behavior of scrap tires. The algorithm includes heat and mass transfer equations to account for the different extents of thermal lag as the tire is heated at different heating rates. The algorithm uses an iterative approach to fit model equations to experimental data to obtain quantitative values of kinetic parameters. These parameters describe the pyrolysis process well, with good agreement (r(2)>0.96) between the model and experimental data when the model is applied to three different brands of automobile tires heated under five different heating rates in a pure nitrogen atmosphere. The model agrees with other researchers' results that frequencies factors increased and time constants decreased with increasing heating rates. The model also shows the change in the behavior of individual tire components when the heating rates are increased above 30 K min(-1). This result indicates that heating rates, rather than temperature, can significantly affect pyrolysis reactions. This algorithm is simple in structure and yet accurate in describing tire pyrolysis under a wide range of heating rates (10-50 K min(-1)). It improves our understanding of the tire pyrolysis process by showing the relationship between the heating rate and the many components in a tire that depolymerize as parallel reactions.

Geographic differences in fractures among women

PubMed Central

Litwic, Anna; Edwards, Mark; Cooper, Cyrus; Dennison, Elaine

2013-01-01

Osteoporotic fracture is associated with considerable morbidity and mortality in women throughout the world. However, significant variation in hip fracture rates among women from different nations have been observed, and are likely to represent a combination of real and apparent differences due to ascertainment bias. Higher rates are observed in Caucasian women, with lowest rates observed in black women and intermediate rates among Asian women. These differences are likely to represent a combination of genetic and environmental differences; for example, among European women, the highest fracture rates are observed in Scandinavian women where vitamin D insufficiency is common. In all groups, an expansion in absolute fracture numbers is anticipated due to demographic changes. PMID:23181532

Schizophrenia in Croatia: interregional differences in prevalence and a comment on constant incidence.

PubMed Central

Folnegović, Z; Folnegović-Smalc, V

1992-01-01

STUDY OBJECTIVE--The aim was to examine why differences exist in schizophrenia prevalence and risk in some areas of Croatia, when schizophrenia incidence rates do not appear to vary. DESIGN--Areas differing by schizophrenia admission rates in patients born in 1953 and admitted by the age of 31 years are compared using a number of indicators relating both to general population characteristics and to those of schizophrenic cases in these populations. SETTING--The study covers the whole of Croatia (4,601,469 inhabitants, 1981 census). SUBJECTS--By the age of 31 years, out of 80,445 individuals born in Croatia in 1953, 464 were admitted for and diagnosed as having schizophrenia. MAIN RESULTS--Admission risk rates are higher in those parts of Croatia where emigration rates are high and lower where immigration rates are high. There is also a positive correlation with schizophrenia prevalence and manic depressive psychosis rates. There is a negative correlation with age of onset of schizophrenia and with schizophrenic reproduction rates. In the study areas, hospital incidence rates are not significantly different. CONCLUSIONS--Economic migration and negative selection in the domestic population are likely to be the most significant factors leading to differences in schizophrenia prevalence. The approximately equal incidence rates in the population, with different prevalence and admission risks, are linked to differences in the disease onset among schizophrenics with a positive family history for this condition. In other words, these patients, when part of the population with a greater prevalence and a greater hereditary loading, experience the onset more often at an earlier age. Thus they have a lower reproduction rate than in a population with a lower prevalence and a lower hereditary loading. Thus incidence rates in populations with different prevalences and different hereditary loads are maintained roughly equal over generations. Images PMID:1645081

Age differences in suprathreshold sensory function.

PubMed

Heft, Marc W; Robinson, Michael E

2014-02-01

While there is general agreement that vision and audition decline with aging, observations for the somatosensory senses and taste are less clear. The purpose of this study was to assess age differences in multimodal sensory perception in healthy, community-dwelling participants. Participants (100 females and 78 males aged 20-89 years) judged the magnitudes of sensations associated with graded levels of thermal, tactile, and taste stimuli in separate testing sessions using a cross-modality matching (CMM) procedure. During each testing session, participants also rated words that describe magnitudes of percepts associated with differing-level sensory stimuli. The words provided contextual anchors for the sensory ratings, and the word-rating task served as a control for the CMM. The mean sensory ratings were used as dependent variables in a MANOVA for each sensory domain, with age and sex as between-subject variables. These analyses were repeated with the grand means for the word ratings as a covariate to control for the rating task. The results of this study suggest that there are modest age differences for somatosensory and taste domains. While the magnitudes of these differences are mediated somewhat by age differences in the rating task, differences in warm temperature, tactile, and salty taste persist.

Individual differences in emotion word processing: A diffusion model analysis.

PubMed

Mueller, Christina J; Kuchinke, Lars

2016-06-01

The exploratory study investigated individual differences in implicit processing of emotional words in a lexical decision task. A processing advantage for positive words was observed, and differences between happy and fear-related words in response times were predicted by individual differences in specific variables of emotion processing: Whereas more pronounced goal-directed behavior was related to a specific slowdown in processing of fear-related words, the rate of spontaneous eye blinks (indexing brain dopamine levels) was associated with a processing advantage of happy words. Estimating diffusion model parameters revealed that the drift rate (rate of information accumulation) captures unique variance of processing differences between happy and fear-related words, with highest drift rates observed for happy words. Overall emotion recognition ability predicted individual differences in drift rates between happy and fear-related words. The findings emphasize that a significant amount of variance in emotion processing is explained by individual differences in behavioral data.

[Estimate the abatement rate of septic tank sewage outfall soil on nitrogen pollutants of typical farmer household sewage].

PubMed

Zhou, Feng; Wang, Wen-Lin; Wang, Guo-Xiang; Ma, Jiu-Yuan; Wan, Yin-Jing; Tang, Xiao-Yan; Liang, Bin; Ji, Bin

2013-10-01

The surface soil on sewage outfall and effluent of farmer household septic tank were collected in situ from the typical region of plain river network areas in Taihu Lake Basin, and the typical rainfall (summer 30 mm . times-1, winter 5 mm times -1), temperature (summer 27 degrees C, winter 5 degrees C ) condition and pollutant load were artificial simulated by indoor simulation soil column experiments for estimating nitrogen abatement rate of rural sewage treated by the outfall soil and exploring the abatement rule in different seasons and weather process (7 days before the rain, 3 rainy days, 7 days after the rain). Results showed that: there was the significant difference (P <0.05) in abatement/increase rate of outfall soil on nitrogen between summer and winter. The TN abatement rate, NO-3 -N increase rate of summer showed a significant difference (P <0.01) among different weather processes, but the NH+4 -N abatement rate of summer and the TN, NH+4 -N abatement rate, NO -N increase rate of winter were not significant (P > 0. 05). Therefore, the TN, NH+4 -N abatement rate, NO-3 -N increase rate need to be divided by seasons, TN abatement rate, NO-3 -N increase rate of summer need to be divided by the weather process, which were 38.5% , - 25.0% , 46. 0% and 478. 1%, 913.8%, 382. 0% , before the rain, in rainy day, after the rain, respectively; while the NH+4 -N abatement rate of summer and the TN, NH+4 -N abatement rate, NO-3 -N increase rate of winter do not need to be divided by weather process, were 91.7% , 50.4% , 85.5% and 276.0% , respectively. In the summer, the TN abatement rate in different weather processes was not correlated with NH+4 -N abatement rate, but significantly negative correlated with NO-3 -N increase rate. In the winter, the stable accumulation of TN in soil was an important reason of the TN abatement rate which had no significant difference and kept a high level among different weather processes, and it was closely related to the stable accumulation of NH+4 -N in soil.

Relative Salience of Speech Rhythm and Speech Rate on Perceived Foreign Accent in a Second Language.

PubMed

Polyanskaya, Leona; Ordin, Mikhail; Busa, Maria Grazia

2017-09-01

We investigated the independent contribution of speech rate and speech rhythm to perceived foreign accent. To address this issue we used a resynthesis technique that allows neutralizing segmental and tonal idiosyncrasies between identical sentences produced by French learners of English at different proficiency levels and maintaining the idiosyncrasies pertaining to prosodic timing patterns. We created stimuli that (1) preserved the idiosyncrasies in speech rhythm while controlling for the differences in speech rate between the utterances; (2) preserved the idiosyncrasies in speech rate while controlling for the differences in speech rhythm between the utterances; and (3) preserved the idiosyncrasies both in speech rate and speech rhythm. All the stimuli were created in intoned (with imposed intonational contour) and flat (with monotonized, constant F0) conditions. The original and the resynthesized sentences were rated by native speakers of English for degree of foreign accent. We found that both speech rate and speech rhythm influence the degree of perceived foreign accent, but the effect of speech rhythm is larger than that of speech rate. We also found that intonation enhances the perception of fine differences in rhythmic patterns but reduces the perceptual salience of fine differences in speech rate.

Behavioral responses of freshwater mussels to experimental dewatering

USGS Publications Warehouse

Galbraith, Heather S.; Blakeslee, Carrie J.; Lellis, William A.

2015-01-01

Understanding the effects of flow alteration on freshwater ecosystems is critical for predicting species responses and restoring appropriate flow regimes. We experimentally evaluated the effects of 3 dewatering rates on behavior of 6 freshwater mussel species in the context of water-removal rates observed in 21 Atlantic Coast rivers. Horizontal movement differed significantly among species and dewatering rates, but a significant species × dewatering interaction suggested that these factors influence movement in complex ways. Species differences in movement were evident only in controls and under slow dewatering rates, but these differences disappeared at moderate and fast dewatering rates. Burrowing behavior did not differ with respect to species identity or dewatering rate. The proportion of individuals that became stranded did not differ among species, but most individuals became stranded under low and moderate dewatering, and all individuals became stranded under fast dewatering. Mortality after stranding differed strongly among species along a gradient from 25% inPyganodon cataracta to 92% in Alasmidonta marginata. Together, these results suggest that species behavior may differ under gradual dewatering, but all species in our study are poorly adapted for rapid dewatering. Most of the 21 rivers we assessed experienced dewatering events comparable to our moderate rate, and several experienced events comparable to our fast rate. Dewatering events that exceed the movement or survival capability of most mussel species can be expected to result in assemblage-wide impacts. Consequently, the rate of water level change may be important in refining target flow conditions for restoration.

Experiments to Evaluate and Implement Passive Tracer Gas Methods to Measure Ventilation Rates in Homes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lunden, Melissa; Faulkner, David; Heredia, Elizabeth

2012-10-01

This report documents experiments performed in three homes to assess the methodology used to determine air exchange rates using passive tracer techniques. The experiments used four different tracer gases emitted simultaneously but implemented with different spatial coverage in the home. Two different tracer gas sampling methods were used. The results characterize the factors of the execution and analysis of the passive tracer technique that affect the uncertainty in the calculated air exchange rates. These factors include uncertainties in tracer gas emission rates, differences in measured concentrations for different tracer gases, temporal and spatial variability of the concentrations, the comparison betweenmore » different gas sampling methods, and the effect of different ventilation conditions.« less

The effects of different rates of ascent on the incidence of altitude decompression sickness

NASA Technical Reports Server (NTRS)

Kumar, K. V.; Waligora, James M.

1989-01-01

The effect of different rates of ascent on the incidence of altitude decompression sickness (DCS) was analyzed by a retrospective study on 14,123 man-flights involving direct ascent up to 38,000 ft altitude. The data were classified on the basis of altitude attained, denitrogenation at ground level, duration of stay at altitude, rest or exercise while at altitude, frequency of exercise at altitude, and ascent rates. This database was further divided on the basis of ascent rates into different groups from 1000 ft/min up to 53,000 ft/min. The database was analyzed using multiple correlation and regression methods, and the results of the analysis reveal that ascent rates influence the incidence of DCS in combination with the various factors mentioned above. Rate of ascent was not a significant predictor of DCS and showed a low, but significant multiple correlation (R=0.31) with the above factors. Further, the effects of rates below 2500 ft/min are significantly different from that of rates above 2500 ft/min on the incidence of symptoms (P=0.03) and forced descent (P=0.01). At rates above 2500 ft/min and up to 53,000 ft/min, the effects of ascent rates are not significantly different (P greater than 0.05) in the population examined while the effects of rates below 2500 ft/min are not clear.

Isochron burial dating of Danube terraces in the course of an interlaboratory comparison on sample preparation in Vienna and Budapest

NASA Astrophysics Data System (ADS)

Neuhuber, Stephanie; Ruszkiczay-Rüdiger, Zsófia; Decker, Kurt; Braucher, Regis; Fiebig, Markus; Braun, Mihály; Häuselmann, Philipp; Aster Team

2016-04-01

The Neogene development of the Vienna Basin's tectonic history is well-documented in seismic sections and hydrocarbon wells. The late Neogene to Quaternary history is less well preserved due to a gap in the sediment record starting from the Late Pannonian due to a large-scale uplift during a phase of basin inversion [1]. Quaternary sediments in the Vienna Basin form prominent Pleistocene terraces north and south of the Danube's recent floodplain. The Danube's course currently shifts to the south where it erodes into its own gravel terraces that were presumably accumulated during the Pliocene and Early to Middle Pleistocene. North of the Danube, a wide alluvial plain has developed with one prominent Middle Quaternary terrace level 17-25 m above the river (Gänserndorf and Schlosshof Terraces). The most recent tectonic events related to the sinistral movement of the Vienna Basin transform fault system are recorded north of the Danube by faulted terrace segments that were identified by paleoseismological trenching in combination with OSL [2]. In contrast, terraces south of the Danube form a staircase with altitudes ranging between 25 and 130 m above todays water level. The terraces in the south have also been strongly dissected by faults [3], each fault block preserved a slightly different succession of terraces. The fault-related vertical displacements south of the Danube have not yet been quantified. To better understand the Quaternary terrace sequence and its displacement in the southern zone, we use the cosmogenic nuclide pair of 26Al and 10Be for isochron burial dating of a Danube terrace at Haslau an der Donau (~40 m above river level). This terrace is locally the lowest of a staircase of a total of 6 different levels. Based on published geomorphological works, the expected age is Middle Pleistocene. The isochron burial dating method is therefore well-suited to date this sedimentary setting due to the presence of large individual clasts that share the same post-depositional history, but have different pre-exposure and transport histories [4]. The sandy gravel of the Haslau terrace was sampled in an active gravel pit. At this location, two major sedimentary units are separated by an erosional hiatus of unknown duration. The upper sequence was sampled at 5.5 m depth and the lower one was sampled at 11.8 m depth. From both depths six quartzite or quartz-bearing cobbles were taken together with a bulk sample from the matrix for isochron burial duration determination. Five samples were split after crushing and sieving and were processed at both the Cosmogenic Nuclide Sample Preparation Laboratory at Vienna and at Budapest (http://www.geochem.hu/kozmogen/Lab_en.html), in order to assess and compare the sample processing preocedures of these recently operating sample preparation laboratories. AMS measurements were performed at the French national facility ASTER (CEREGE (Aix-en-Provence, France). Thanks to OTKA PD83610, NKM-96/2014, NKM-31/2015; OMAA 90öu17; LP2012-27/2012. INSU/CNRS, the ANR through the program "EQUIPEX Investissement d'Avenir", IRD and CEA. [1] Decker et al., 2005. QSR 24, 307-322 [2] Hintersberger et al, 2013, EGU2013-12755 [3] Salcher et al. 2012. Tectonics, 31, TC3004, doi:10.1029/2011TC002979 [4] Balco and Rovey, 2008. AJS 908, 1083-1114 [5] Fuchs and Grill, 1984, Geologische Gebietskarte der Republik Österreich 1:200 000 Wien und Umgebung

Late Pleistocene deglaciation and paleo-environment in the Retezat Mountains, Southern Carpathians

NASA Astrophysics Data System (ADS)

Ruszkiczay-Rüdiger, Zsófia; Madarász, Balázs; Kern, Zoltán; Urdea, Petru; Braucher, Régis; Aster Team

2017-04-01

This study aims to use in situ produced 10Be based Cosmic Ray Exposure (CRE) ages to reconstruct glacier evolution in the Retezat Mts, the Southern Carpathians most glaciated area with peak elevations up to 2509 m asl. In the study area currently devoid of glaciers, the calculated theoretical ELA is at ˜2860 m asl. The paleo-Equilibrium Line Altitudes (ELAs) were calculated over the ˜21 to ˜13 ka time period based on the reconstructed glacial stillstands or re-advances geometries using the ssAAR method [1, 2]. Regarding the Northern side of the Retezat Mts, new and re-evaluated 10Be CRE ages (n=34) [3] were used while regarding the Southern side, they all result from a new sampling (n=25). According to the data, the most extended glaciation occurred during the LGM, down to ˜1050 m asl. on both sides of the Retezat Mts with most probable 10Be CRE ages of 21.0 -1.5+0.8 ka and 20.7 -1.0+0.9 ka. The reconstructed ELA depression in the North was ˜1010 m while it was ˜1190 m, in the South where the valleys glacial system (Lăpuşnicu - Judele) was significantly larger with longer glacier tongues. At the beginning of the Lateglacial (˜17-18 ka) the glaciers withdrew and the North-South difference between the ELA depression was decreased (˜885 m and ˜945 m, respectively). The ELA differences further reduced and vanished for the ˜15.3 ka glacial event - the last cold stage before the abrupt Bölling/Alleröd warming - with ELA depressions of ˜728 m and ˜712 m, respectively. The last glacial phase in the area characterized by small cirque glaciers occurred at 13.5 -0.6+0.6 ka in the North and 13.9 -0.4+0.9 ka in the South. By this time, the ELA depression was reduced to ˜660-680 m. Due to the small glacier size this value may have been influenced by local topoclimatic factors. So far, no data support Younger Dryas or Holocene glaciation of the Retezat Mts. The elevation difference of the ELAs suggests more precipitation on the Southern side of the Retezat Mts during the LGM. This may indicate a southerly wind regime at this part of Europe, which subsequently gave place to the westerly winds during the warming climate of the Lateglacial. Using a Chironomidae-based summer temperature (T) reconstruction from the area [4], T and mean annual precipitation (P) at the ELA were calculated for the ˜15.3 ka stage. Based on Ohmura et al. [5] a ˜4.5-4.9 ˚ C decrease of T and a ˜10-15% increase of P compared to the present values were calculated. Thanks to OTKA PD83610, PD104899; NKM-96/2014, NKM-31/2015; OMAA 90öu17; LP2012-27/2012, INSU/CNRS, the ANR through the program "EQUIPEX Investissement d'Avenir", IRD and CEA. References: [1] Pellitero et al. 2015 Computers & Gerosciences 82: 55-62 [2] Kern and László, 2010. Quat. Sci. Rev. 29, 2781-2787. [3] Ruszkiczay-Rüdiger et al. 2016 Quat. Int. 415. 216-229. [4] Tóth et al., 2012. Quat. Res. 77. 122-131. [5] Ohmura et al. 1992. J. of Glaciology, 38. 397-411.

Impact of the Amount of Liquid Intake on the Dose Rate of Patients Treated with Radioiodine.

PubMed

Haghighatafshar, Mahdi; Banani, Aida; Zeinali-Rafsanjani, Banafsheh; Etemadi, Zahra; Ghaedian, Tahereh

2018-01-01

Despite therapeutic effects of radioiodine in patients with differentiated thyroid cancer, there are some disadvantages due to harmful radiation to other tissues. According to the current guidelines, patients are recommended to drink lots of water and frequent voiding to reduce the amount of 131 I in the body. This study was designed to assess the impact of the amount of liquid intake on reduction of the measured dose rate of radioiodine-treated patients. A total of 42 patients with differentiated thyroid cancer without metastasis who had undergone total thyroidectomy and had been treated with radioiodine were selected. The patients were divided into two groups according to the amount of their fluid intake which was measured during the first 48 h after 131 I administration. In all patients, the dose rate was measured immediately and 48 h after iodine administration. Each group included 21 patients. Dose rate ratio (the ratio of the second dose rate to the first dose rate) and dose rate difference ratio (the ratio of the difference between the two measured dose rates to the first dose rate) were calculated for each patient. Despite the significant difference in the amount of the liquid drunk, no statistically significant difference was seen between the different groups in parameters of dose-rate ratio and dose-rate difference ratio. Higher fluid intake (>60 ml/h in our study) alone would not effectively reduce the patient's radiation dose rate at least not more than a well-hydrated state. It seems that other interfering factors in the thyroidectomized patients may also have some impacts on this physiologic process.

Effect of Discharge Rate on Positive Active Material of Lead Carbon Battery for Energy Storage

NASA Astrophysics Data System (ADS)

Chen, Kailun; Liu, Hao; Hu, Chen; Gao, Fei; Yang, Kai; Wang, Hao

2017-10-01

Lead carbon battery has been widespread concern with its excellent performance of charge and discharge under High Rate Part State of Charge (HRPSoC) as well as its cycle performance. In this paper, the cycling performance of lead carbon battery for energy storage was tested by different discharge rate. The effects of different discharge rate on the composition and morphology of positive active materials in the cycle was studied by XRD and SEM. The effect of different discharge rate on the ohmic impedance of lead carbon battery was studied by testing Electrochemical Impedance Spectroscopy with different capacity retention rates. The results show that with the increase of the discharge rate, the content of PbO2 in the positive active material increases, the active substance utilization and the particle size of PbO2 crystal declines, and the ohmic impedance of the battery decreases.

Night and Day: Are Siblings as Different in Temperament as Parents Say They Are?

PubMed Central

Saudino, Kimberly J.; Wertz, Annie E.; Gagne, Jeffrey R.; Chawla, Sonia

2005-01-01

Twin studies suggest that parent ratings of temperament exaggerate differences between twins. The present study examined whether such contrast effects also operate for nontwin siblings. The activity level (AL) and shyness of 95 nontwin sibling pairs (ages 3 to 8 years) were assessed via parent ratings and objective measures (actigraph and observer ratings). Siblings showed no resemblance in either parent-rated AL or shyness; however, sibling resemblance for actigraph AL and observer-rated shyness was substantial. Thus, parents do contrast their nontwin siblings when rating these 2 temperament dimensions. Moreover, the importance of sibling differences in temperament to the sibling relationship and differential maternal treatment varied across the different measures of AL and shyness, suggesting that parent perceptions may play a role in these associations. PMID:15535780

The Effect of Weaving on the Strength of Kevlar KM2 Single Fibers at Different Loading Rates

DTIC Science & Technology

2012-12-01

The Effect of Weaving on the Strength of Kevlar KM2 Single Fibers at Different Loading Rates by Brett Sanborn, Nicole Racine, and Tusit...Ground, MD 21005-5069 ARL-TR-6280 December 2012 The Effect of Weaving on the Strength of Kevlar KM2 Single Fibers at Different Loading Rates...Effect of Weaving on the Strength of Kevlar KM2 Single Fibers at Different Loading Rates 5a. CONTRACT NUMBER 1120-1120-99 5b. GRANT NUMBER 5c

Why Are Child Poverty Rates Higher in Britain than in Germany? A Longitudinal Perspective

ERIC Educational Resources Information Center

Jenkins, Stephen P.; Schluter, Christian

2003-01-01

We analyze why child poverty rates were much higher in Britain than in Western Germany during the 1990s, using a framework focusing on poverty transition rates. Child poverty exit rates were significantly lower, and poverty entry rates significantly higher, in Britain. We decompose these cross-national differences into differences in the…

29 CFR 778.115 - Employees working at two or more rates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.115... different types of work for which different nonovertime rates of pay (of not less than the applicable minimum wage) have been established, his regular rate for that week is the weighted average of such rates...

Comparison of cutting efficiency with different diamond burs and water flow rates in cutting lithium disilicate glass ceramic.

PubMed

Siegel, Sharon C; Patel, Tejas

2016-10-01

This study compared different diamond burs and different water flow rates on the cutting efficiency of sectioning through lithium disilicate glass ceramic. The authors used a standardized cutting regimen with 4 brands of diamond burs to section through lithium disilicate glass ceramic blocks. Twelve diamonds of each brand cut through the blocks in randomized order. In the first part of the study, the authors recorded sectioning rates in millimeters per minute for each diamond bur as a measure of cutting efficiency. In the second part of the study, the authors compared sectioning rates using only 1 brand of diamond bur, with 3 different water flow rates. The authors averaged and compared cutting rates of each brand of diamond bur and the cutting rates for each flow rate using an analysis of variance and determined the differences with a Tukey honest significant difference test. One diamond bur cut significantly slower than the other 3, and one diamond bur cut significantly faster than 2 of the others. The diamond bur cutting efficiency through lithium disilicate glass ceramic with a 20 mL/min water flow rate was significantly higher than 15 mL/min. There are differences in cutting efficiency between diamond burs when sectioning lithium disilicate glass ceramic. Use a minimum of 20 mL/min of water coolant flow when sectioning lithium disilicate glass ceramic with dental diamond burs to maximize cutting efficiency. Recommendations for specific diamond burs with a coarse grit and water flow rate of 20 mL/min can be made when removing or adjusting restorations made from lithium disilicate glass ceramic. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

Post-treatment speech naturalness of comprehensive stuttering program clients and differences in ratings among listener groups.

PubMed

Teshima, Shelli; Langevin, Marilyn; Hagler, Paul; Kully, Deborah

2010-03-01

The purposes of this study were to investigate naturalness of the post-treatment speech of Comprehensive Stuttering Program (CSP) clients and differences in naturalness ratings by three listener groups. Listeners were 21 student speech-language pathologists, 9 community members, and 15 listeners who stutter. Listeners rated perceptually fluent speech samples of CSP clients obtained immediately post-treatment (Post) and at 5 years follow-up (F5), and speech samples of matched typically fluent (TF) speakers. A 9-point interval rating scale was used. A 3 (listener group)x2 (time)x2 (speaker) mixed ANOVA was used to test for differences among mean ratings. The difference between CSP Post and F5 mean ratings was statistically significant. The F5 mean rating was within the range reported for typically fluent speakers. Student speech-language pathologists were found to be less critical than community members and listeners who stutter in rating naturalness; however, there were no significant differences in ratings made by community members and listeners who stutter. Results indicate that the naturalness of post-treatment speech of CSP clients improves in the post-treatment period and that it is possible for clients to achieve levels of naturalness that appear to be acceptable to adults who stutter and that are within the range of naturalness ratings given to typically fluent speakers. Readers will be able to (a) summarize key findings of studies that have investigated naturalness ratings, and (b) interpret the naturalness ratings of Comprehensive Stuttering Program speaker samples and the ratings made by the three listener groups in this study.

Proxy rated quality of life of care home residents with dementia: a systematic review.

PubMed

Robertson, Sarah; Cooper, Claudia; Hoe, Juanita; Hamilton, Olivia; Stringer, Aisling; Livingston, Gill

2017-04-01

Quality of life (QoL) is an important outcome for people with dementia living in care homes but usually needs to be rated by a proxy. We do not know if relative or paid carer proxy reports differ. We conducted the first systematic review and meta-analysis of data investigating whether and how these proxy reports of QoL differ. We searched four databases: Medline, Embase, PsychInfo, and CINAHL in October 2015 with the terms: dementia, QoL, proxy, and care home. Included studies either compared proxy QoL ratings or investigated the factors associated with them. We meta-analyzed data comparing staff and family proxy rated QoL. We included 17/105 papers identified. We found no difference between global proxy ratings of QoL (n = 1,290; pooled effect size 0.06 (95% CI = -0.08 to 0.19)). Studies investigating factors associated with ratings (n = 3,537) found family and staff ratings correlated with the resident's physical and mental health. Staff who were more distressed rated resident QoL lower. Relatives rated it lower when the resident had lived in the care home for longer, when they observed more restraint, or contributed more to fees. Relatives and staff proxy QoL ratings share a clear relationship to resident health and overall ratings were similar. Rater-specific factors were, however, also associated with scores. Understanding why different raters consider the QoL of the same person differently is an important consideration when evaluating the meaning of proxy rated QoL. Proxy raters' backgrounds may affect their rating of QoL.

Gender- and age-related differences in heart rate dynamics: are women more complex than men?

NASA Technical Reports Server (NTRS)

Ryan, S. M.; Goldberger, A. L.; Pincus, S. M.; Mietus, J.; Lipsitz, L. A.

1994-01-01

OBJECTIVES. This study aimed to quantify the complex dynamics of beat-to-beat sinus rhythm heart rate fluctuations and to determine their differences as a function of gender and age. BACKGROUND. Recently, measures of heart rate variability and the nonlinear "complexity" of heart rate dynamics have been used as indicators of cardiovascular health. Because women have lower cardiovascular risk and greater longevity than men, we postulated that there are important gender-related differences in beat-to-beat heart rate dynamics. METHODS. We analyzed heart rate dynamics during 8-min segments of continuous electrocardiographic recording in healthy young (20 to 39 years old), middle-aged (40 to 64 years old) and elderly (65 to 90 years old) men (n = 40) and women (n = 27) while they performed spontaneous and metronomic (15 breaths/min) breathing. Relatively high (0.15 to 0.40 Hz) and low (0.01 to 0.15 Hz) frequency components of heart rate variability were computed using spectral analysis. The overall "complexity" of each heart rate time series was quantified by its approximate entropy, a measure of regularity derived from nonlinear dynamics ("chaos" theory). RESULTS. Mean heart rate did not differ between the age groups or genders. High frequency heart rate power and the high/low frequency power ratio decreased with age in both men and women (p < 0.05). The high/low frequency power ratio during spontaneous and metronomic breathing was greater in women than men (p < 0.05). Heart rate approximate entropy decreased with age and was higher in women than men (p < 0.05). CONCLUSIONS. High frequency heart rate spectral power (associated with parasympathetic activity) and the overall complexity of heart rate dynamics are higher in women than men. These complementary findings indicate the need to account for gender-as well as age-related differences in heart rate dynamics. Whether these gender differences are related to lower cardiovascular disease risk and greater longevity in women requires further study.

Judged Lethality

DTIC Science & Technology

1980-12-01

Biases in Judged Death Rates Relative to Median Error Ratio in Each Group, Experiment 1 12 Table 5: Direction of Secondary Bias, Experiment 1 14 Table 6...translated into death rates per 100,000 individuals afflicted. The death rate group estimated these rates directly. For the number died group, which was... rates . The four columns differ markedly in the magnitude of the death rates they include. These differences provide an ordering of the response modes by

Association of Biodiversity with the Rates of Micropollutant Biotransformations among Full-Scale Wastewater Treatment Plant Communities

PubMed Central

Helbling, Damian E.; Lee, Tae Kwon; Park, Joonhong; Fenner, Kathrin; Kohler, Hans-Peter E.; Ackermann, Martin

2014-01-01

Biodiversities can differ substantially among different wastewater treatment plant (WWTP) communities. Whether differences in biodiversity translate into differences in the provision of particular ecosystem services, however, is under active debate. Theoretical considerations predict that WWTP communities with more biodiversity are more likely to contain strains that have positive effects on the rates of particular ecosystem functions, thus resulting in positive associations between those two variables. However, if WWTP communities were sufficiently biodiverse to nearly saturate the set of possible positive effects, then positive associations would not occur between biodiversity and the rates of particular ecosystem functions. To test these expectations, we measured the taxonomic biodiversity, functional biodiversity, and rates of 10 different micropollutant biotransformations for 10 full-scale WWTP communities. We have demonstrated that biodiversity is positively associated with the rates of specific, but not all, micropollutant biotransformations. Thus, one cannot assume whether or how biodiversity will associate with the rate of any particular micropollutant biotransformation. We have further demonstrated that the strongest positive association is between biodiversity and the collective rate of multiple micropollutant biotransformations. Thus, more biodiversity is likely required to maximize the collective rates of multiple micropollutant biotransformations than is required to maximize the rate of any individual micropollutant biotransformation. We finally provide evidence that the positive associations are stronger for rare micropollutant biotransformations than for common micropollutant biotransformations. Together, our results are consistent with the hypothesis that differences in biodiversity can indeed translate into differences in the provision of particular ecosystem services by full-scale WWTP communities. PMID:25398862

Ice thickness profile surveying with ground penetrating radar at Artesonraju Glacier, Peru

NASA Astrophysics Data System (ADS)

Chisolm, Rachel; Rabatel, Antoine; McKinney, Daene; Condom, Thomas; Cochacin, Alejo; Davila Roller, Luzmilla

2014-05-01

Tropical glaciers are an essential component of the water resource systems in the mountainous regions where they are located, and a warming climate has resulted in the accelerated retreat of Andean glaciers in recent decades. The shrinkage of Andean glaciers influences the flood risk for communities living downstream as new glacial lakes have begun to form at the termini of some glaciers. As these lakes continue to grow in area and volume, they pose an increasing risk of glacial lake outburst floods (GLOFs). Ice thickness measurements have been a key missing link in studying the tropical glaciers in Peru and how climate change is likely to impact glacial melt and the growth of glacial lakes. Ground penetrating radar (GPR) has rarely been applied to glaciers in Peru to measure ice thickness, and these measurements can tell us a lot about how a warming climate will affect glaciers in terms of thickness changes. In the upper Paron Valley (Cordillera Blanca, Peru), an emerging lake has begun to form at the terminus of the Artesonraju Glacier, and this lake has key features, including overhanging ice and loose rock likely to create slides, that could trigger a catastrophic GLOF if the lake continues to grow. Because the glacier mass balance and lake mass balance are closely linked, ice thickness measurements and measurements of the bed slope of the Artesonraju Glacier and underlying bedrock can give us an idea of how the lake is likely to evolve in the coming decades. This study presents GPR data taken in July 2013 at the Artesonraju Glacier as part of a collaboration between the Unidad de Glaciologia y Recursos Hidricos (UGRH) of Peru, the Institut de Recherche pour le Développement (IRD) of France and the University of Texas at Austin (UT) of the United States of America. Two different GPR units belonging to UGRH and UT were used for subsurface imaging to create ice thickness profiles and to characterize the total volume of ice in the glacier. A common midpoint survey was also undertaken to determine the radar velocity in the ice at Artesonraju Glacier. GPR measurements of Artesonraju Glacier show the ice thickness ranging from 20 meters at the terminus and gradually increasing to about 160 meters at the deepest part in the tongue of the glacier. After this point the bed slope begins to increase and the ice thickness decreases in the direction of the accumulation zone. A negative bed slope from the glacier terminus to the middle of the glacier tongue indicates that the conditions are favorable for the growth of a glacial lake with a potential maximum depth of about 60-80 m.

Cooling rates of group IVA iron meteorites

NASA Technical Reports Server (NTRS)

Willis, J.; Wasson, J. T.

1978-01-01

Cooling rates of six group IVA iron meteorites were estimated by a taenite central Ni concentration-taenite half-width method. Calculated cooling rates range from 13 to 25 C/Myr, with an average of 20 C/Myr. No correlation between cooling rate and bulk Ni content is observed, and the data appear to be consistent with a uniform cooling rate as expected from an igneous core origin. This result differs from previous studies reporting a wide range in cooling rates that were strongly correlated with bulk Ni content. The differences result mainly from differences in the phase diagram and the selected diffusion coefficients. Cooling rates inferred from taenite Ni concentrations at the interface with kamacite are consistent with those based on taenite central Ni content.

The Role of Children's Ethnicity in the Relationship between Teacher Ratings of Attention-Deficit/Hyperactivity Disorder and Observed Classroom Behavior

ERIC Educational Resources Information Center

Epstein, Jeffrey N.; Willoughby, Michael; Valencia, Elvia Y.; Tonev, Simon T.; Abikoff, Howard B.; Arnold, L. Eugene; Hinshaw, Stephen P.

2005-01-01

Significant ethnic differences have been consistently documented on attention-deficit/hyperactivity disorder (ADHD) teacher rating scales. Whether these ethnic differences result from a teacher rating bias or reflect actual classroom behavior patterns is unknown. Ethnic differences between Caucasian and African American (AA) elementary…

Cardiovascular Fitness and Maximal Heart Rate Differences Among Three Ethnic Groups.

ERIC Educational Resources Information Center

Farrell, S. W.

1988-01-01

Examination of differences in maximal heart rate and treadmill time among three ethnic groups revealed no significant age-adjusted differences among white, black, and Mexican-American males, and suggested that black females' lower maximal heart rate may be explained by their lower cardiovascular fitness level when compared to those of other…

National assessment of shoreline change: Historical shoreline change in the Hawaiian Islands

USGS Publications Warehouse

Fletcher, Charles H.; Romine, Bradley M.; Genz, Ayesha S.; Barbee, Matthew M.; Dyer, Matthew; Anderson, Tiffany R.; Lim, S. Chyn; Vitousek, Sean; Bochicchio, Christopher; Richmond, Bruce M.

2012-01-01

Rates of shoreline change presented herein may differ from other published rates, and differences do not necessarily indicate that the other rates are inaccurate. Some discrepancies are to be expected, considering the many possible ways of determining shoreline positions and rates of change, and the inherent uncertainty in calculating these rates. Rates of shoreline change presented in this report represent shoreline movement under past conditions and are not intended for use in predicting future shoreline positions or future rates of shoreline change.

EFFECT OF DELAYED AUDITORY FEEDBACK, SPEECH RATE, AND SEX ON SPEECH PRODUCTION.

PubMed

Stuart, Andrew; Kalinowski, Joseph

2015-06-01

Perturbations in Delayed Auditory Feedback (DAF) and speech rate were examined as sources of disruptions in speech between men and women. Fluent adult men (n = 16) and women (n = 16) spoke at a normal and an imposed fast rate of speech with 0, 25, 50, 100, and 200 msec. DAF. The syllable rate significantly increased when participants were instructed to speak at a fast rate, and the syllable rate decreased with increasing DAF delays. Men's speech rate was significantly faster during the fast speech rate condition with a 200 msec. DAF. Disfluencies increased with increasing DAF delay. Significantly more disfluency occurred at delays of 25 and 50 msec. at the fast rate condition, while more disfluency occurred at 100 and 200 msec. in normal rate conditions. Men and women did not display differences in the number of disfluencies. These findings demonstrate sex differences in susceptibility to perturbations in DAF and speech rate suggesting feedforward/feedback subsystems that monitor vocalizations may be different between sexes.

Atenolol Is Associated with Lower Day of Surgery Heart Rate as compared to Long and Short-acting Metoprolol

PubMed Central

Schonberger, Robert B.; Brandt, Cynthia; Feinleib, Jessica; Dai, Feng; Burg, Matthew M.

2012-01-01

Objectives We analyzed the association between outpatient beta-blocker type and day-of-surgery heart rate in ambulatory surgical patients. We further investigated whether differences in day of surgery heart rate between atenolol and metoprolol could be explained by once-daily versus twice-daily dosing regimens. Design Retrospective observational study. Setting VA Hospital Participants Ambulatory surgical patients on chronic atenolol or metoprolol. Interventions None. Measurements and Main Results Using a propensity-score matched cohort, we compared day of surgery heart rates of patients prescribed atenolol versus metoprolol. We then differentiated between once-daily and twice-daily metoprolol formulations and compared day of surgery heart rates within a general linear model. Day of surgery heart rates in patients prescribed atenolol vs. any metoprolol formulation were slower by a mean of 5.1 beats/min (66.6 vs. 71.7; 95% CI of difference 1.9 to 8.3, p=0.002), a difference that was not observed in preoperative primary care visits. The general linear model demonstrated that patients prescribed atenolol (typically QD dosing) had a mean day of surgery heart rate 5.6 beats/min lower compared to patients prescribed once-daily metoprolol succinate (68.9 vs. 74.5; 95% CI of difference: −8.6 to −2.6, p<0.001) and 3.8 beats/minute lower compared to patients prescribed twice-daily metoprolol tartrate (68.9 vs. 72.7; 95% CI of difference: −6.1 to −1.6, p<0.001). Day of surgery heart rates were similar between different formulations of metoprolol (95% CI of difference: −1.0 to +4.6, p=0.22). Conclusions Atenolol is associated with lower day of surgery heart rate vs. metoprolol. The heart rate difference is specific to the day of surgery and is not explained by once-daily versus twice-daily dosing regimens. PMID:22889605

Positivity rates of antithyroid antibody, antinuclear antibody and thyroid peroxidase antibody in different types of vitiligo.

PubMed

Lim, H K; Bae, M I; Jeong, K H; Shin, M K; Lee, M-H

2016-04-01

Vitiligo is associated with various autoimmune disorders, and organ-specific autoantibodies are frequently found in patients with this disorder. Vitiligo is classically divided into segmental vitiligo (SV) and nonsegmental vitiligo (NSV), and it is believed that the pathogenesis differs between these two types. As the NSV type is related to an autoimmune mechanism, autoantibody detection rates are likely to be higher in the NSV type than in the segmental type; however, no comparative studies have been performed. To analyse the rates of autoantibody positivity according to the clinical features in patients with vitiligo. Rates of antithyroid antibody (Tg Ab), antinuclear antibody (ANA) and thyroid peroxidase antibody (TPO Ab) positivity were analysed and compared according to the sex, clinical type and age of onset of 807 patients with vitiligo. There were 106 patients with SV (13.1%) and 701 patients with NSV (86.9%). Tg Ab and ANA positivity did not differ between the SV and NSV types. A positive TPO Ab result was obtained in 16 patients with SV (15.1%) and 173 patients with NSV (24.7%). The TPO Ab positivity rate was significantly higher in NSV (χ² = 4.14, P < 0.05). The positivity rates of the three autoantibodies differed significantly according to age of onset (P = 0.001, P = 0.02 and P < 0.001 for Tg Ab, ANA and TPO Ab positivity, respectively). The TPO Ab positivity rate also showed a sex difference (P < 0.001). The positivity rates for the three autoantibodies showed differences according to age of onset and sex. The rates of Tg Ab and ANA positivity showed no significant differences according to clinical type, but the TPO Ab positivity rate was significantly different between SV and NSV. It appears likely that an autoimmune mechanism contributes to the pathogenesis of SV. © 2015 British Association of Dermatologists.

Strain rate dependent calcite microfabric evolution - an experiment carried out by nature

NASA Astrophysics Data System (ADS)

Rogowitz, A.; Huet, B.; Grasemann, B.; Habler, G.

2013-12-01

The deformation behaviour of calcite has been studied extensively in a number of experiments. Different strain rates and pressure and temperature conditions have been used to investigate a wide range of deformation regimes. However, a direct comparison with natural fault rocks remains difficult because of extreme differences between experimental and natural strain rates. A secondary shear zone (flanking structure) developed in almost pure calcite marble on Syros (Greece). Due to rotation of an elliptical inclusion (crack) a heterogeneous strain field in the surrounding area occurred resulting in different strain domains and the formation of the flanking structure. Assuming that deformation was active continuously during the development of the flanking structure, the different strain domains correspond to different strain-rate domains. The outcrop thus represents the final state of a natural experiment and gives us a great opportunity to get natural constraints on strain rate dependent deformation behaviour of calcite. Comparing the microfabrics in the 1 to 2.5 cm thick shear zone and the surrounding host rocks, which formed under the same metamorphic conditions but with different strain rates, is the central focus of this study. Due to the extreme variation in strain and strain rate, different microstructures and textures can be observed corresponding to different deformation mechanisms. With increasing strain rate we observe a change in dominant deformation mechanism from dislocation glide to dislocation creep and finally diffusion creep. Additionally, a change from subgrain rotation (SGR) to bulging (BLG) recrystallization can be observed in the dislocation creep regime. Textures and the degree of intracrystalline deformation have been measured by electron back scatter diffraction (EBSD). At all strain rates clear CPOs developed leading to the assumption that calcite preferentially deforms within the dislocation creep field. However, we can also find clear evidence for grain size sensitive deformation mechanisms at smaller grain sizes (3.6 μm) consistent with experimental observations and determined flaw laws. Although mylonitic layers evolve at high (10^-10 s^-1) and intermediate strain rates (10^-11 s^-1) by SGR recrystallization we observe variations in texture leading to the assumption that at varying strain rates different gliding systems were active. The results of this study are compared with experimental data, closing the gap between experimental and natural geological strain rates.

Race-Ethnic Differences in the Non-marital Fertility Rates in 2006-2010.

PubMed

Kim, Yujin; Raley, R Kelly

2015-02-01

Research in the 1980s pointed to the lower marriage rates of blacks as an important factor contributing to race differences in non-marital fertility. Our analyses update and extend this prior work to investigate whether cohabitation has become an important contributor to this variation. We use data from the 2006-2010 National Survey of Family Growth (NSFG) and to identify the relative contribution of population composition (i.e. percent sexually active single and percent cohabiting) versus rates (pregnancy rates, post-conception marriage rates) to race-ethnic variation in non-marital fertility rates (N=7,428). We find that the pregnancy rate among single (not cohabiting) women is the biggest contributor to race-ethnic variation in the non-marital fertility rate and that contraceptive use patterns among racial minorities explains the majority of the race-ethnic differences in pregnancy rates.

Laboratory measurements of electrical resistivity versus water content on small soil cores

NASA Astrophysics Data System (ADS)

Robain, H.; Camerlynck, C.; Bellier, G.; Tabbagh, A.

2003-04-01

The assessment of soil water content variations more and more leans on geophysical methods that are non invasive and that allow a high spatial sampling. Among the different methods, DC electrical imaging is moving forward. DC Electrical resistivity shows indeed strong seasonal variations that principally depend on soil water content variations. Nevertheless, the widely used Archie's empirical law [1], that links resistivity with voids saturation and water conductivity is not well suited to soil materials with high clay content. Furthermore, the shrinking and swelling properties of soil materials have to be considered. Hence, it is relevant to develop new laboratory experiments in order to establish a relation between electrical resistivity and water content taking into account the rheological and granulometrical specificities of soil materials. The experimental device developed in IRD laboratory allows to monitor simultaneously (i) the water content, (ii) the electrical resistivity and (iii) the volume of a small cylindrical soil core (100cm3) put in a temperature controlled incubator (30°C). It provides both the shrinkage curve of the soil core (voids volume versus water content) and the electrical resistivity versus water content curve The modelisation of the shrinkage curve gives for each moisture state the water respectively contained in macro and micro voids [2], and then allows to propose a generalized Archie's like law as following : 1/Rs = 1/Fma.Rma + 1/Fmi.Rmi and Fi = Ai/(Vi^Mi.Si^Ni) with Rs : the soil resistivity. Fma and Fmi : the so called "formation factor" for macro and micro voids, respectively. Rma and Rmi : the resistivity of the water contained in macro and micro voids, respectively. Vi : the volume of macro and micro voids, respectively. Si : the saturation of macro and micro voids, respectively. Ai, Mi and Ni : adjustment coefficients. The variations of Rmi are calculated, assuming that Rma is a constant. Indeed, the rise of ionic concentration in water may be neglected during the sewage of macro voids as it corresponds to a small quantity of water for the studied samples. Soil solid components are generally electrical insulators, the conduction of electrical current only lies on two phenomenon occurring in water : (i) volume conduction controlled by the electrolyte concentration in water and the geometrical characteristics of macro voids network ; (ii) surface conduction controlled by the double diffuse layer that depends on the solid-liquid interactions, the specific surface of clay minerals and the geometry of particles contacts. For the water contained in macro voids the preeminent phenomenon seems to be volume conduction while for the water contained in micro voids, it seems to be surface conduction. This hypothesis satisfyingly explains the shape of the electrical resistivity versus water content curves obtained for three different oxisols with clayey, clayey-sandy and sandy-clayey texture. [1] Archie G.E. 1942. The electrical resistivity log as an aid in determining some reservoirs characteristics. Trans. AIME, 146, 54-67. [2] Braudeau E. et al. 1999. New device and method for soil shrinkage curve measurement and characterization. S.S.S.A.J., 63(3), 525-535.

PREFACE: 1st International Symposium on Electrical Arc and Thermal Plasmas in Africa (ISAPA)

NASA Astrophysics Data System (ADS)

Andre, Pascal; Koalaga, Zacharie

2012-02-01

Logos of the University of Ouagadougou, ISAPA and Universite Blaise Pascal Africa (especially Sub-Saharan Africa) is a continent where electrification is at a low level. However, the development of the electrical power sector is a prerequisite for the growth of other industrial activities, that is to say for the social and economic development of African countries. Consequently, a large number of electrification projects (rural electrification, interconnection of different country's grids) takes place in many countries. These projects need expertise and make Africa a continent of opportunity for companies in different domains for business and research: energy; energetic production, transmission, distribution and protection of electricity; the supply of cable; the construction, engineering and expertise in the field of solar and wind power. The first International Symposium on electrical Arc and thermal Plasma in Africa (ISAPA) was held for the first time in Ouagadougou, Burkina Faso to progress and develop the research of new physical developments, technical breakthroughs, and ideas in the fields of electrical production and electrical applications. The ISAPA aims to encourage the advancement of the science and applications of electrical power transformation in Africa by bringing together specialists from many areas in Africa and the rest of the world. Such considerations have led us to define a Scientific Committee including representatives from many countries. This first meeting was an innovative opportunity for researchers and engineers from academic and industrial sectors to exchange views and knowledge. Both fundamental aspects such as thermal plasma, electrical arc, diagnostics and applied aspects as circuit breakers, ICP analyses, photovoltaic energy conversion and alternative energies, as well as space applications were covered. The Laboratory of Material and Environment (LAME) from Ouagadougou University and the Laboratory of Electric Arc and Thermal Plasmas (LAEPT) from Blaise Pascal University have worked in close collaboration within the framework of the Organizing Committee of this new and first ISAPA symposium in Africa. We registered 40 participants from France, Portugal, Belgium, Mali, Niger, Togo, Tchad and, of course, Burkina Faso, and also through collaborative works from Russia, Poland and Ukraine. 20 papers, one poster and 3 oral contributions were presented for this first ISAPA. The ISAPA Symposium has been held with the material and financial support of the following organizations: EDULINK Program of EU-ACP; SCAC Service of the French Embassy in Burkina Faso; IRD (Institute of Development Research) Burkina Faso; ASDI/SAREC project in Burkina Faso; University of Ouagadougou, Burkina Faso; Blaise Pascal University of Clermont Ferrand, France. The opening ceremony of ISAPA Symposium was presided over by two ministers: the minister in charge of secondary and higher education (MESS) and the minister in charge of scientific research and innovation (MRSI). Thus, they have marked the interest given by the government of Burkina Faso for RAMSES Scientific Meetings such as ISAPA. Zacharie Koalaga (LAME, University of Ouagadougou, Burkina Faso) Pascal André (LAEPT, Blaise Pascal University, France) ISAPA 2011 Co-Chairmen of the ISAPA International Organizing Committee and editors Logos

Some critical methodological issues in secondary analysis of world health organization data on elderly suicide rates.

PubMed

Shah, Ajit

2009-07-01

Suicides may be misclassified as accidental deaths in countries with strict legal definitions of suicide, with cultural and religious factors leading to poor registration of suicide and stigma attached to suicide. The concordance between four different definitions of suicides was evaluated by examining the relationship between pure suicide and accidental death rates, gender differences, age-associated trends and potential distil risk and protective factors by conducting secondary analysis of the latest World Health Organisation data on elderly death rates. The four definitions of suicide were: (i) one-year pure suicides rates; one-year combined suicide rates (pure suicide rates combined with accidental death rates); (iii) five-year average pure suicide rates; and (iv) five-year average combined suicides rates (pure suicides rates combined with accidental death rates). The predicted negative correlation between pure suicide and accidental death rates was not observed. Gender differences were similar for all four definitions of suicide. There was a highly significant concordance for the findings of age-associated trends between one-year pure and combined suicide rates, one-year and five-year average pure suicide rates, and five-year average pure and combined suicide rates. There was poor concordance between pure and combined suicide rates for both one-year and five-year average data for the 14 potential distil risk and protective factors, but this concordance between one-year and five-year average pure suicide rates was highly significant. The use of one-year pure suicide rates in cross-national ecological studies examining gender differences, age-associated trends and potential distil risk and protective factors is likely to be practical, pragmatic and resource-efficient.

Crash Fatality Rates After Recreational Marijuana Legalization in Washington and Colorado.

PubMed

Aydelotte, Jayson D; Brown, Lawrence H; Luftman, Kevin M; Mardock, Alexandra L; Teixeira, Pedro G R; Coopwood, Ben; Brown, Carlos V R

2017-08-01

To evaluate motor vehicle crash fatality rates in the first 2 states with recreational marijuana legalization and compare them with motor vehicle crash fatality rates in similar states without recreational marijuana legalization. We used the US Fatality Analysis Reporting System to determine the annual numbers of motor vehicle crash fatalities between 2009 and 2015 in Washington, Colorado, and 8 control states. We compared year-over-year changes in motor vehicle crash fatality rates (per billion vehicle miles traveled) before and after recreational marijuana legalization with a difference-in-differences approach that controlled for underlying time trends and state-specific population, economic, and traffic characteristics. Pre-recreational marijuana legalization annual changes in motor vehicle crash fatality rates for Washington and Colorado were similar to those for the control states. Post-recreational marijuana legalization changes in motor vehicle crash fatality rates for Washington and Colorado also did not significantly differ from those for the control states (adjusted difference-in-differences coefficient = +0.2 fatalities/billion vehicle miles traveled; 95% confidence interval = -0.4, +0.9). Three years after recreational marijuana legalization, changes in motor vehicle crash fatality rates for Washington and Colorado were not statistically different from those in similar states without recreational marijuana legalization. Future studies over a longer time remain warranted.

[Occurrence and survival condition of lung cancer with different histologies among residents in Pudong new area].

PubMed

Chen, Hanyi; Yang, Chen; Yan, Bei; Sun, Lianghong; Wu, Zheng; Li, Xiaopan; Zhang, Meiyu; Li, Xiaoli; Yang, Liming

2014-03-01

Different histologies of lung cancer vary in occurrence and prognosis. This study aims to analyze the incidence and occurrence trend of lung cancer and investigate the survival rate and its influential factors among lung cancer patients with different histologies. Permanent residents were recruited between 2002 and 2009 in Pudong New Area (former Nanhui Area and former Pudong Area), Shanghai, China. Annual percent changes were estimated by a linear regression of the logarithm on the incidence rates for eight years. Survival rates were calculated and compared by using life-table analysis and Log-rank test, respectively. The standardized incidence rates of lung cancer were 52.28 and 18.86 per 100,000 in males and females, respectively. The median survival time was 410.72 days for specific classified lung cancer. The incidence rates of adenocarcinoma ranked the highest and showed an upward tendency (P<0.05). Patients with small cell lung cancer showed the worst survival condition. The survival condition in males with squamous cell lung cancer living in former Nanhui Area was better compared with those living in former Pudong Area. Lung cancers with different histologies demonstrated different occurrence trends and survival rates. Gender, age, and living area influence the survival rates of lung cancer with different histologies.

Rapid estimation of glucosinolate thermal degradation rate constants in leaves of Chinese kale and broccoli (Brassica oleracea) in two seasons.

PubMed

Hennig, Kristin; Verkerk, Ruud; Bonnema, Guusje; Dekker, Matthijs

2012-08-15

Kinetic modeling was used as a tool to quantitatively estimate glucosinolate thermal degradation rate constants. Literature shows that thermal degradation rates differ in different vegetables. Well-characterized plant material, leaves of broccoli and Chinese kale plants grown in two seasons, was used in the study. It was shown that a first-order reaction is appropriate to model glucosinolate degradation independent from the season. No difference in degradation rate constants of structurally identical glucosinolates was found between broccoli and Chinese kale leaves when grown in the same season. However, glucosinolate degradation rate constants were highly affected by the season (20-80% increase in spring compared to autumn). These results suggest that differences in glucosinolate degradation rate constants can be due to variation in environmental as well as genetic factors. Furthermore, a methodology to estimate rate constants rapidly is provided to enable the analysis of high sample numbers for future studies.

Somatosensory Gating Is Dependent on the Rate of Force Recruitment in the Human Orofacial System

ERIC Educational Resources Information Center

Andreatta, Richard D.; Barlow, Steven M.

2009-01-01

Purpose: Functional orofacial behaviors vary in their force endpoint and rate of recruitment. This study assessed the gating of orofacial cutaneous somatosensation during different cyclic lip force recruitment rates. Understanding how differences in the rate of force recruitment influences trigeminal system function is an important step toward…

A comparison of response rates in the English Longitudinal Study of Ageing and the Health and Retirement Study

PubMed Central

Cheshire, Hayley; Ofstedal, Mary Beth; Scholes, Shaun; Schroeder, Mathis

2013-01-01

Survey response rates are an important measure of the quality of a survey; this is true for both longitudinal and cross-sectional surveys. However, the concept of a response rate in the context of a panel survey is more complex than is the case for a cross-sectional survey. There are typically many different response rates that can be calculated for a panel survey, each of which may be relevant for a specific purpose. The main objective of our paper is to document and compare response rates for two long-term panel studies of ageing, the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS) in the United States. To guide our selection and calculation of response rates for the two studies, we use a framework that was developed by Peter Lynn (2005) and present several different types of longitudinal response rates for the two surveys. We discuss similarities and differences in the study designs and protocols and how some of the differences affect comparisons of response rates across the two studies. PMID:24432049

[Study on morphology, quality and germination characteristics of Acanthopanax trifoliatus seeds under different habitats].

PubMed

Xiao, Juan

2014-05-01

To preliminary explore the difference of the morphological, quality and germinal characteristics of Acanthopanax trifoliatus seeds under different habitats. Collect the wild seeds from different habitats in West Mountain, and then observe their external appearances and internal structure, and test the thousand seeds weight,water content and seed vigor. What's more, the influence to germination rates of the seeds from different temperatures and light intensities in artificial bioclimatic chamber was studied. Orthogonal test in experimental plots was carried out to screen the different sowing dates, matrix types and soil depths which may influence germination rate. The external appearances and quality characteristics of wild seeds from three habitats were different. Seeds could germinate in the both light and dark, the germination rate of the habitat II was as high as 70.5% at the optimum temperature 20 degrees C in artificial bioclimatic chamber. The optimal combination A1, B1, C1 was screened out through orthogonal test, namely, the germination rate would be the highest when the seeds sowed in autumn covering with 2 cm depth of matrix type which component of the ratio of soil, sand and organic fertilizer was 6: 3: 1. There was significant difference in the morphology and germination rate of the three habitats seeds. The habitat II seeds were the optimal choice when culture seedling. The influences of different temperatures on germination rate were different, and the dried seeds should sow in current autumn, better than the next spring.

Regional differences of standardised mortality rates for ischemic heart diseases in the Slovak Republic for the period 1996-2013 in the context of income inequality.

PubMed

Gavurová, Beáta; Vagašová, Tatiana

2016-12-01

The aim of paper is to analyse the development of standardised mortality rates for ischemic heart diseases in relation to the income inequality in the regions of Slovakia. This paper assesses different types of income indicators, such as mean equivalised net income per household, Gini coefficient, unemployment rate, at risk of poverty threshold (60 % of national median), S80/S20 and their effect on mortality. Using data from the Slovak mortality database 1996-2013, the method of direct standardisation was applied to eliminate variances resulted from differences in age structures of the population across regions and over time. To examine the relationships between income indicators and standardised mortality rates, we used the tools of descriptive statistics and methods of correlation and regression analysis. At first, we show that Slovakia has the worst values of standardised mortality rates for ischemic heart diseases in EU countries. Secondly, mortality rates are significantly higher for males compared with females. Thirdly, mortality rates are improving from Eastern Slovakia to Western Slovakia; additionally, high differences in the results of variability are seen among Slovak regions. Finally, the unemployment rate, the poverty rate and equivalent disposable income were statistically significant income indicators. Main contribution of paper is to demonstrate regional differences between mortality and income inequality, and to point out the long-term unsatisfactory health outcomes.

Human Genetic Variation and Yellow Fever Mortality during 19th Century U.S. Epidemics

PubMed Central

2014-01-01

ABSTRACT We calculated the incidence, mortality, and case fatality rates for Caucasians and non-Caucasians during 19th century yellow fever (YF) epidemics in the United States and determined statistical significance for differences in the rates in different populations. We evaluated nongenetic host factors, including socioeconomic, environmental, cultural, demographic, and acquired immunity status that could have influenced these differences. While differences in incidence rates were not significant between Caucasians and non-Caucasians, differences in mortality and case fatality rates were statistically significant for all epidemics tested (P < 0.01). Caucasians diagnosed with YF were 6.8 times more likely to succumb than non-Caucasians with the disease. No other major causes of death during the 19th century demonstrated a similar mortality skew toward Caucasians. Nongenetic host factors were examined and could not explain these large differences. We propose that the remarkably lower case mortality rates for individuals of non-Caucasian ancestry is the result of human genetic variation in loci encoding innate immune mediators. PMID:24895309

Effects of scan rate on the corrosion behavior SS 304 stainless steel in the nanofluid measured by Tafel polarization methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prajitno, Djoko Hadi

The Effects of scan rate on the Tafel polarization curve that is obtained to determine corrosion rate are conducted. The tafel polarization curves are obtained at different scan rates for Stainless Steel 304 in nanofluids contain 0.01 gpl nano particle ZrO{sub 2}. The corrosion stainless steel in nanofluid contains adm+0.01 gpl ZrO{sub 2} nanoparticles at different scan rate was performed by Tafel polarization. The results show that according corrosion potential examination of the stainless steel in nanofluid media 0.01gpl ZrO{sub 2} nanoparticle was actively corroded. The value of cathodic Tafel slope stainless steel in nanofluid at different scan rate relativelymore » unchanged after polarization testing. Mean while the value of anodic Tafel slope stainless steel in nanofluid increase at different scan rate. The results of Tafel polarization technique show that corrosion rate of stainless steel in nanofluid increase with increasing scan rate. X ray diffraction examination of stainless steel after Tafel polarization depict that γ Fe phase is major phase in the surface of alloy.« less

Heart rate measurement as a tool to quantify sedentary behavior.

PubMed

Åkerberg, Anna; Koshmak, Gregory; Johansson, Anders; Lindén, Maria

2015-01-01

Sedentary work is very common today. The aim of this pilot study was to attempt to differentiate between typical work situations and to investigate the possibility to break sedentary behavior, based on physiological measurement among office workers. Ten test persons used one heart rate based activity monitor (Linkura), one pulse oximeter device (Wrist) and one movement based activity wristband (Fitbit Flex), in different working situations. The results showed that both heart rate devices, Linkura and Wrist, were able to detect differences in heart rate between the different working situations (resting, sitting, standing, slow walk and medium fast walk). The movement based device, Fitbit Flex, was only able to separate differences in steps between slow walk and medium fast walk. It can be concluded that heart rate measurement is a promising tool for quantifying and separating different working situations, such as sitting, standing and walking.

Effects of changes in palatability on food intake and the cumulative food intake curve in man.

PubMed

Bobroff, E M; Kissileff, H R

1986-03-01

This study was undertaken to quantify the relationship between palatability ratings and food consumption and to determine whether the initial rate of eating was affected by changes in food palatability without a change in nutrient content. Both men and women were given small samples of foods at a brief exposure taste test and asked to rate how much they liked or disliked them on a 9-point scale (like extremely to dislike extremely). Those who gave at least a 2-point difference in rating between a banana colada frozen yogurt drink with and without adulteration with cumin were given these foods to eat to satiety on non-consecutive days, and the same 9-point scale was used to rate these foods after they had been eaten as meals. Cumin was used as an adulterant because it is not intrinsically unpalatable, but is not liked by many individuals in yogurt-based foods. Intake was approximately 100 g different for every unit of difference on the scale, and higher for liked than disliked food. Intake was significantly different between the adulterated and unadulterated meals. The percentage of variance explained by the difference in palatability was 34% of the total variance but was 67% of the variance within subjects. Correlation between intake and ratings were poor across subjects for both palatability levels (i.e. adulterated and unadulterated). The initial rate of eating was significantly higher under the better liked than under the less liked food. These results indicate that quantification of effects of hedonic ratings on intake within subjects is possible, but that hedonic ratings may not be good discriminators of intake differences between subjects. The initial rate of eating reflects partly on palatability.

A clinical study to compare between resting and stimulated whole salivary flow rate and pH before and after complete denture placement in different age groups

PubMed Central

Muddugangadhar, B. C.; Sangur, Rajashekar; Rudraprasad, I. V.; Nandeeshwar, D. B.; Kumar, B. H. Dhanya

2015-01-01

Purpose: This study compared the flow rate and pH of resting (unstimulated) and stimulated whole saliva before and after complete denture placement in different age groups. Materials and Methods: Fifty healthy, non-medicated edentulous individuals of different age groups requiring complete denture prostheses were selected from the outpatient department. The resting (unstimulated) and stimulated whole saliva and pH were measured at three stages i.e., i)Before complete denture placement;ii)Immediately after complete denture placement; andiii)After 2 to 3 months of complete denture placement. Saliva production was stimulated by chewing paraffin wax. pH was determined by using a digital pH meter. Results: Statistically significant differences were seen in resting(unstimulated) and stimulated whole salivary flow rate and pH obtained before, immediately after, and after 2 to 3 months of complete denture placement. No statistically significant differences were found between the different age groups in resting (unstimulated) as well as stimulated whole salivary flow rate and pH. Conclusion: Stimulated whole salivary flow rates and pH were significantly higher than resting (unstimulated) whole salivary flow rates and pH obtained before, immediately after, and after 2 to 3 months of complete denture placement. No age related variations in whole salivary flow rate and pH were observed in healthy, non-medicated individuals. Clinical Implications: The assessment of salivary flow rate, pH in different age groups is of prognostic value, which is an important aspect to be considered in the practice of removable prosthodontics. PMID:26929540

A clinical study to compare between resting and stimulated whole salivary flow rate and pH before and after complete denture placement in different age groups.

PubMed

Muddugangadhar, B C; Sangur, Rajashekar; Rudraprasad, I V; Nandeeshwar, D B; Kumar, B H Dhanya

2015-01-01

This study compared the flow rate and pH of resting (unstimulated) and stimulated whole saliva before and after complete denture placement in different age groups. Fifty healthy, non-medicated edentulous individuals of different age groups requiring complete denture prostheses were selected from the outpatient department. The resting (unstimulated) and stimulated whole saliva and pH were measured at three stages i.e., i)Before complete denture placement;ii)Immediately after complete denture placement; andiii)After 2 to 3 months of complete denture placement. Saliva production was stimulated by chewing paraffin wax. pH was determined by using a digital pH meter. Statistically significant differences were seen in resting(unstimulated) and stimulated whole salivary flow rate and pH obtained before, immediately after, and after 2 to 3 months of complete denture placement. No statistically significant differences were found between the different age groups in resting (unstimulated) as well as stimulated whole salivary flow rate and pH. Stimulated whole salivary flow rates and pH were significantly higher than resting (unstimulated) whole salivary flow rates and pH obtained before, immediately after, and after 2 to 3 months of complete denture placement. No age related variations in whole salivary flow rate and pH were observed in healthy, non-medicated individuals. The assessment of salivary flow rate, pH in different age groups is of prognostic value, which is an important aspect to be considered in the practice of removable prosthodontics.

Format effects in two teacher rating scales of hyperactivity.

PubMed

Sandoval, J

1981-06-01

The object of this study was to investigate the effect of differences in format on the precision of teacher ratings and thus on the reliability and validity of two teacher rating scales of children's hyperactive behavior. Teachers (N = 242) rated a sample of children in their classrooms using rating scales assessing similar attributes with different formats. For a sub-sample the rating scales were readministered after 2 weeks. The results indicated that improvement can be made in the precision of teacher ratings that may be reflected in improved reliability and validity.

Pitfalls in the statistical examination and interpretation of the correspondence between physician and patient satisfaction ratings and their relevance for shared decision making research

PubMed Central

2011-01-01

Background The correspondence of satisfaction ratings between physicians and patients can be assessed on different dimensions. One may examine whether they differ between the two groups or focus on measures of association or agreement. The aim of our study was to evaluate methodological difficulties in calculating the correspondence between patient and physician satisfaction ratings and to show the relevance for shared decision making research. Methods We utilised a structured tool for cardiovascular prevention (arriba™) in a pragmatic cluster-randomised controlled trial. Correspondence between patient and physician satisfaction ratings after individual primary care consultations was assessed using the Patient Participation Scale (PPS). We used the Wilcoxon signed-rank test, the marginal homogeneity test, Kendall's tau-b, weighted kappa, percentage of agreement, and the Bland-Altman method to measure differences, associations, and agreement between physicians and patients. Results Statistical measures signal large differences between patient and physician satisfaction ratings with more favourable ratings provided by patients and a low correspondence regardless of group allocation. Closer examination of the raw data revealed a high ceiling effect of satisfaction ratings and only slight disagreement regarding the distributions of differences between physicians' and patients' ratings. Conclusions Traditional statistical measures of association and agreement are not able to capture a clinically relevant appreciation of the physician-patient relationship by both parties in skewed satisfaction ratings. Only the Bland-Altman method for assessing agreement augmented by bar charts of differences was able to indicate this. Trial registration ISRCTN: ISRCT71348772 PMID:21592337

Comparison of smoking cessation between education groups: findings from 2 US National Surveys over 2 decades.

PubMed

Zhuang, Yue-Lin; Gamst, Anthony C; Cummins, Sharon E; Wolfson, Tanya; Zhu, Shu-Hong

2015-02-01

We examined smoking cessation rate by education and determined how much of the difference can be attributed to the rate of quit attempts and how much to the success of these attempts. We analyzed data from the National Health Interview Survey (NHIS, 1991-2010) and the Tobacco Use Supplement to the Current Population Survey (TUS-CPS, 1992-2011). Smokers (≥ 25 years) were divided into lower- and higher-education groups (≤ 12 years and >12 years). A significant difference in cessation rate between the lower- and the higher-education groups persisted over the last 2 decades. On average, the annual cessation rate for the former was about two thirds that of the latter (3.5% vs 5.2%; P<.001, for both NHIS and TUS-CPS). About half the difference in cessation rate can be attributed to the difference in quit attempt rate and half to the difference in success rate. Smokers in the lower-education group have consistently lagged behind their higher-education counterparts in quitting. In addition to the usual concern about improving their success in quitting, tobacco control programs need to find ways to increase quit attempts in this group.

Research on spatial distribution of photosynthetic characteristics of Winter Wheat

NASA Astrophysics Data System (ADS)

Yan, Q. Q.; Zhou, Q. Y.; Zhang, B. Z.; Han, X.; Han, N. N.; Li, S. M.

2018-03-01

In order to explore the spatial distribution of photosynthetic characteristics of winter wheat leaf, the photosynthetic rate on different parts of leaf (leaf base-leaf middle-leaf apex) and that on each canopy (top layer-middle layer-bottom layer) leaf during the whole growth period of winter wheat were measured. The variation of photosynthetic rate with PAR and the spatial distribution of winter wheat leaf during the whole growth periods were analysed. The results showed that the photosynthetic rate of different parts of winter wheat increased with the increase of PAR, which was showed as leaf base>leaf middle>leaf apex. In the same growth period, photosynthetic rate in different parts of the tablet was showed as leaf middle>leaf base>leaf apex. For the different canopy layer of winter wheat, the photosynthetic rate of the top layer leaf was significantly greater than that of the middle layer and lower layer leaf. The photosynthetic rate of the top layer leaf was the largest in the leaf base position. The photosynthetic rate of leaf of the same canopy layer at different growth stages were showed as tasseling stage >grain filling stage > maturation stage.

Perceptual and Cognitive Factors Imposing “Speed Limits” on Reading Rate: A Study with the Rapid Serial Visual Presentation

PubMed Central

Spinelli, Donatella; Zoccolotti, Pierluigi; De Luca, Maria; Martelli, Marialuisa

2016-01-01

Adults read at high speed, but estimates of their reading rate vary greatly, i.e., from 100 to 1500 words per minute (wpm). This discrepancy is likely due to different recording methods and to the different perceptual and cognitive processes involved in specific test conditions. The present study investigated the origins of these notable differences in RSVP reading rate (RR). In six experiments we investigated the role of many different perceptual and cognitive variables. The presence of a mask caused a steep decline in reading rate, with an estimated masking cost of about 200 wpm. When the decoding process was isolated, RR approached values of 1200 wpm. When the number of stimuli exceeded the short-term memory span, RR decreased to 800 wpm. The semantic context contributed to reading speed only by a factor of 1.4. Finally, eye movements imposed an upper limit on RR (around 300 wpm). Overall, data indicate a speed limit of 300 wpm, which corresponds to the time needed for eye movement execution, i.e., the most time consuming mechanism. Results reconcile differences in reading rates reported by different laboratories and thus provide suggestions for targeting different components of reading rate. PMID:27088226

Does ASA classification impact success rates of endovascular aneurysm repairs?

PubMed

Conners, Michael S; Tonnessen, Britt H; Sternbergh, W Charles; Carter, Glen; Yoselevitz, Moises; Money, Samuel R

2002-09-01

The purpose of this study was to evaluate the technical success, clinical success, postoperative complication rate, need for a secondary procedure, and mortality rate with endovascular aneurysm repair (EAR), based on the physical status classification scheme advocated by the American Society of Anesthesiologists (ASA). At a single institution 167 patients underwent attempted EAR. Query of a prospectively maintained database supplemented with a retrospective review of medical records was used to gather statistics pertaining to patient demographics and outcome. In patients selected for EAR on the basis of acceptable anatomy, technical and clinical success rates were not significantly different among the different ASA classifications. Importantly, postoperative complication and 30-day mortality rates do not appear to significantly differ among the different ASA classifications in this patient population.

Common medium versus advanced IVF medium for cryopreserved oocytes in heterologous cycles.

PubMed

Poverini, R; Lisi, R; Lisi, F; Berlinghieri, V; Bielli, W; Carfagna, P; Costantino, A; Iacomino, D; Nicodemo, G

2018-12-01

Granulocyte-macrophage colony-stimulation factor plays different crucial roles during embryo implantation and subsequent development. Here we aimed to evaluate the effects of embryo cell culture medium, with the inclusion of granulocyte-macrophage colony-stimulation factor (GM-CSF), on embryo development and pregnancy rate. To this end, we took advantage of our retrospective observational study to correlate the outcomes from two different culture media. We included in this study 25 unselected patient from our IVF Center that underwent heterologous IVF cycle with crypreserved oocytes. We analyze the fertilization rate, pregnancy rate, and embryo quality at different day of transfer obtained from two different media composition. Our results show that the rate of fertilization and the pregnancy rate were increased using medium added with this particular type of cytokines (GM-CSF).

U.S. spousal homicide rates by racial composition of marriage.

PubMed

Roberts, John M

2015-09-01

American spousal homicide rates persistently and substantially vary by racial composition of the married couple. Analyses examined different racial couple types' spousal homicide rates in light of nonspousal homicide victimization and offending rates and couple types' average social, demographic, and economic characteristics. Analyses used 2003 to 2007 spousal homicide data from Supplementary Homicide Reports for which missing data have been multiply imputed. Current Population Survey data provided estimates of the number and average characteristics of different couple types. Log-linear models related couple types' differing spousal homicide rates to different race-sex groups' general rates of homicide victimization and offending and couple types' average characteristics. Among couple types with at least 50,000 couples, annual rates of male-on-female spousal homicide ranged from 0.95 to 8.76 per 100,000 couples; for female-on-male spousal homicide, this range was 0.13 to 2.29. Rates somewhat reflect different race-sex groups' nonspousal homicide activity, but with greater gender disparity and an excess of spousal homicide in some couple types. The association between victim's and offender's race is parsimoniously described by models using couple types' average characteristics (proportion with female's education exceeding the male's, proportion in central cities, and relative frequency). General homicidal-violence reduction strategies may partly apply to spousal homicide, but specifically targeted efforts are required too. Interventions must address different couple types' particular social, economic, and cultural experiences. Copyright © 2015 Elsevier Inc. All rights reserved.

Reliability of Untrained and Experienced Raters on FEES: Rating Overall Residue is a Simple Task.

PubMed

Pisegna, Jessica M; Borders, James C; Kaneoka, Asako; Coster, Wendy J; Leonard, Rebecca; Langmore, Susan E

2018-03-07

The purpose of this study was to investigate the reliability of residue ratings on Fiberoptic Endoscopic Evaluation of Swallowing (FEES). We also examined rating differences based on experience to determine if years of experience influenced residue ratings. A group of 44 raters watched 81 FEES videos representing a wide range of residue severities for thin liquid, applesauce, and cracker boluses. Raters were untrained on the rating scales and simply rated their overall impression of residue amount on a visual analog scale (VAS) and a five-point ordinal scale in a randomized fashion across two sessions. Intra-class correlation coefficients, kappa coefficients, and ANOVAs were used to analyze agreement and differences in ratings. Residue ratings on both the VAS and ordinal scales had acceptable inter- and intra-rater reliability. Inter-rater agreement was acceptable (ICC > 0.7) for all comparisons. Intra-rater agreement was excellent on the VAS scale (r c  = 0.9) and good on the ordinal scale (k = 0.78). There was no significant difference between expert ratings and other raters based on years of experience for cracker ratings (p = 0.2119) and applesauce ratings (p = 0.2899), but there was a significant difference between clinicians on thin liquid ratings (p = 0.0005). Without any specific training, raters demonstrated high reliability when rating the overall amount of residue on FEES. Years of experience with FEES did not influence residue ratings, suggesting that expert ratings of overall residue amount are not unique or specialized. Rating the overall amount of residue on FEES appears to be a simple visual-perceptual task for puree and cracker boluses.

Effects of changing ambient temperature on metabolic, heart, and ventilation rates during steady state hibernation in golden-mantled ground squirrels (Spermophilus lateralis).

PubMed

Zimmer, M B; Milsom, W K

2001-01-01

To determine whether metabolic rate is suppressed in a temperature-independent fashion in the golden-mantled ground squirrel during steady state hibernation, we measured body temperature and metabolic rate in ground squirrels during hibernation at different T(a)'s. In addition, we attempted to determine whether heart rate, ventilation rate, and breathing patterns changed as a function of body temperature or metabolic rate. We found that metabolic rate changed with T(a) as it was raised from 5 degrees to 14 degrees C, which supports the theory that different species sustain falls in metabolic rate during hibernation in different ways. Heart rate and breathing pattern also changed with changing T(a), while breathing frequency did not. That the total breathing frequency did not correlate closely with oxygen consumption or body temperature, while the breathing pattern did, raises important questions regarding the mechanisms controlling ventilation during hibernation.

Graphical representation of QT rate correction formulae: an aid facilitating the use of a given formula and providing a visual comparison of the impact of different formulae.

PubMed

Rowlands, Derek J

2012-01-01

The QT interval on the electrocardiogram is an increasingly important measurement, especially in relation to drug action and interaction. The QT interval varies inversely as the heart rate and numerous rate correction formulae have been proposed. It is difficult to compare the effect of applying different formulae at different heart rates and for different measured QT intervals. A simple graphical display of the results from different formulae is proposed. This display is dependent on the concept of the absolute correction factor. This graphical presentation is useful (a) in comparing the effect of the application of different formulae and (b) in directly reading the correction produced by any individual formula. Copyright © 2012 Elsevier Inc. All rights reserved.

Volcano Monitoring in Ecuador: Three Decades of Continuous Progress of the Instituto Geofisico - Escuela Politecnica Nacional

NASA Astrophysics Data System (ADS)

Ruiz, M. C.; Yepes, H. A.; Hall, M. L.; Mothes, P. A.; Ramon, P.; Hidalgo, S.; Andrade, D.; Vallejo Vargas, S.; Steele, A. L.; Anzieta, J. C.; Ortiz, H. D.; Palacios, P.; Alvarado, A. P.; Enriquez, W.; Vasconez, F.; Vaca, M.; Arrais, S.; Viracucha, G.; Bernard, B.

2014-12-01

In 1988, the Instituto Geofisico (IG) began a permanent surveillance of Ecuadorian volcanoes, and due to activity on Guagua Pichincha, SP seismic stations and EDM control lines were then installed. Later, with the UNDRO and OAS projects, telemetered seismic monitoring was expanded to Tungurahua, Cotopaxi, Cuicocha, Chimborazo, Antisana, Cayambe, Cerro Negro, and Quilotoa volcanoes. In 1992 an agreement with the Instituto Ecuatoriano de Electrificacion strengthened the monitoring of Tungurahua and Cotopaxi volcanoes with real-time SP seismic networks and EDM lines. Thus, background activity levels became established, which was helpful because of the onset of the 1999 eruptive activity at Tungurahua and Guagua Pichincha. These eruptions had a notable impact on Baños and Quito. Unrest at Cotopaxi volcano was detected in 2001-2002, but waned. In 2002 Reventador began its eruptive period which continues to the present and is closely monitored by the IG. In 2006 permanent seismic BB stations and infrasound sensors were installed at Tungurahua and Cotopaxi under a cooperative program supported by JICA, which allowed us to follow Tungurahua's climatic eruptions of 2006 and subsequent eruptions up to the present. Programs supported by the Ecuadorian Secretaria Nacional de Ciencia y Tecnologia and the Secretaria Nacional de Planificacion resulted in further expansion of the IG's monitoring infrastructure. Thermal and video imagery, SO2 emission monitoring, geochemical analyses, continuous GPS and tiltmeters, and micro-barometric surveillance have been incorporated. Sangay, Soche, Ninahuilca, Pululahua, and Fernandina, Cerro Azul, Sierra Negra, and Alcedo in the Galapagos Islands are now monitored in real-time. During this time, international cooperation with universities (Blaise Pascal & Nice-France, U. North Carolina, New Mexico Tech, Uppsala-Sweden, Nagoya, etc.), and research centers (USGS & UNAVCO-USA, IRD-France, NIED-Japan, SGC-Colombia, VAAC, MIROVA) has introduced the use of new technologies and methods. An agreement with the Secretaria de Gestion de Riesgos fortifies the communication flow to society, officials, and risk managers. Today the IG has the challenge of offering real-time information through a web-based net of virtual observatories.

Controlled cobalt doping in the spinel structure of magnetosome magnetite: New evidences from element- and site-specific XMCD analyses

NASA Astrophysics Data System (ADS)

Pan, Y.; LI, J.; Menguy, N.; Arrio, M. A.; Sainctavit, P.; Juhin, A.; Wang, Y.; Chen, H.; Bunau, O.; Otero, E.; Ohresser, P.

2016-12-01

Controlled cobalt doping in the spinel structure of magnetosome magnetite: New evidences from element- and site-specific XMCD analyses Jinhua Li1,2*, Nicolas Menguy2,3, Marie-Anne Arrio3, Philippe Sainctavit3,4, Amélie Juhin3, Yinzhao Wang1,2, Haitao Chen5, Oana Bunau3, Edwige Otero4, Philippe Ohresser4, Yongxin Pan1,21Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China. 2France-China Biomineralization and Nano-structures Laboratory, Chinese Academy of Sciences, Beijing 100029, China. 3IMPMC, CNRS UMR 7590, Sorbonne Universités, MNHN, UPMC, IRD UMR 206, 75005 Paris, France. 4Synchrotron SOLEIL, L'Orme des Merisiers Saint-Aubin, 91192 Gif-sur-Yvette Cedex, France. 5Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China *To whom correspondence may be addressed. Email: lijinhua@mail.iggcas.ac.cnThe biomineralization of magnetite nanocrystals (called magnetosomes) by magnetotactic bacteria (MTB) has attracted intense interest in biology, geology and materials science. Great efforts have been recently made in producing transition metal-doped magnetosomes with modified magnetic properties for a range of applications. However, the coordination chemistry and magnetism of such metal-doped magnetosomes still remains largely unknown. Here, we present new evidences from X-ray magnetic circular dichroism (XMCD) for element- and site-specific magnetic analyses that cobalt is incorporated in the spinel structure of the magnetosomes within Magnetospirillum magneticum AMB-1 through the replacement of Fe2+ ions by Co2+ ions in octahedral (Oh) sites of magnetite. Compared with non-doped one, cobalt-doped magnetosome sample has lower Verwey transition temperature and larger magnetic coercivity, related to the amount of doped cobalt. This study this study indicates a biologically controlled process on cobalt doping and magnetic alteration by MTB system. ACKNOWLEDGMENTS. This study was financially supported by the NSFC projects (grants 41374004, 41522402, and 41330104) and the French program ANR-blanc (project MS-MCNP and project SWITCH). JHL is grateful for the Open Project Support from the State Key Laboratory of Lithospheric Evolution (IGGCAS).

Developing an event stratigraphy for Heinrich Event 4 at Eirik Drift, South of Greenland

NASA Astrophysics Data System (ADS)

Stanford, Jennifer; Abbott, Peter; Davies, Siwan

2014-05-01

Heinrich events are characterised in North Atlantic sediments by horizons with increased Ice Rafted Debris (IRD) concentrations, low foraminiferal abundances, and light planktonic foraminiferal calcite δ18O (meltwater dilution). They occurred quasi-periodically with a spacing of 5,000-14,000 yrs (Hemming, 2004). It is commonly believed that large iceberg/meltwater injections likely caused slowdowns of the Atlantic Meridional Overturning Circulation (AMOC). However, Stanford et al. (2011) showed, using a basin-wide reconstruction of Heinrich Event 1 (~19-15 ka BP), which was based upon marine and terrestrial records on carefully scrutinised age models, that the main iceberg discharge event occurred some ~1000 years after the initial AMOC slowdown. The study highlighted the importance of robust chronological constraints in order to permit the development of a process understanding of the evolution of such climate events, by evaluation of statistical uncertainty and robust quantification of leads and lags in the ocean-climate system. Here, we present initial results from a marine sediment core recovered from Eirik Drift, South of Greenland, that span the time period that encompasses Heinrich Event 4 (35-45 ka BP). Today, sediments on Eirik Drift are deposited and reworked by the Deep Western Boundary Current (DWBC) and are also located beneath the pathway of the East Greenland and East Greenland Coastal Currents. Hence, Eirik Drift is a crucial monitoring site of surface and deep waters that exit the Arctic via the Denmark Strait. We here combine a proxy record for North Atlantic Deep Water (NADW) flow intensity (κARM/κ) with co-registered records of surface water conditions and place these on a palaeomagnetic and tephrochronologic stratigraphic framework. Given that this chronological framework is independent of environmental influences, basin-wide signal comparison is therefore permissible. Hemming, S. R. (2004), Heinrich Events: Massive Late Pleistocene detritus layers of the North Atlantic and their global imprint, Rev. Geophys., 42, 1-43. J.D. Stanford, Rohling, E. J., Bacon, S., Roberts, A. P, Grousset, F. E. & Bolshaw, M. (2011), A new concept for the paleoceanographic evolution of Heinrich event 1 in the North Atlantic, Quaternary Science Reviews, 20, 1047-1066

Paleocurrents in the Charlie-Gibbs Fracture Zone during the Late Quaternary

NASA Astrophysics Data System (ADS)

Bashirova, L. D.; Dorokhova, E.; Sivkov, V.; Andersen, N.; Kuleshova, L. A.; Matul, A.

2017-12-01

The sedimentary processes prevailing in the Charlie-Gibbs Fracture Zone (CGFZ) are gravity flows. They rework pelagic sediments and contourites, and hereby mask the paleoceanographic information partly. The aim of this work is to study sediments of the AMK-4515 core taken in eastern part of the CGFZ. The sediment core AMK-4515 (52°03.14" N, 29°00.12" W; 370 cm length, water depth 3590 m) is located in the southern valley of the CGFZ. This natural deep corridor is influenced by both the westward Iceland-Scotland Overflow Water and underlying counterflow from the Newfoundland Basin. An alternation of the calcareous silty clays and hemipelagic clayey muds in the studied section indicates similarity between our core and long cores taking from CGFZ. A sharp facies shift was found at 80 cm depth in the investigated core. Only the upper section (0-80 cm) is valid for paleoreconstruction. Planktonic foraminiferal distribution and sea-surface temperature (SST) derived from these allow for tracing the PF and NAC latitudinal migrations during investigated period. So-called sortable silt mean size (SS) was used as proxy for reconstruction of bottom current intensity. The age model is based on δ18O and AMS 14C dating, as well as ice-rafted debris (IRD) counts and CaCO3 content. Stratigraphic subdivision of this section allows to allocate 2 marine isotope stages (MIS) covering the last 27 ka. We refer sediments below this level (80-370 cm) to upper part of turbidite, which was formed as a result of massive slide in the southern channel of the CGFZ. Sandy particles were deposited first, underlying silts and clays. This short-term event occurred so quickly that pelagic sedimentation played no role and was not reflected in the grain size distributions. There is evidence for the significant role of gravity flows in sedimentation in the southern channel of the CGFZ. According to our data, the massive sediment slide occurred in the CGFZ about 27 ka. The authors are grateful to RSF (grant No.14-50-00095) for financial support of analytical studies. Absolute datings were obtained with support from the IKBFU 5-100 Russian academic excellence project.

Crustal Seismicity and 3-D Velocity Structure in the Principal Cordillera of Central Chile (33- 34.5 S, 69.5-71 W): Implications on Andean Geodynamic and Seismic Hazard

NASA Astrophysics Data System (ADS)

Pardo, M.; Monfret, T.; Vera, E.; Yañez, G.; Eisenberg, A.

2007-12-01

Based on data from a dense local temporary seismological network, crustal seismicity is characterized, and a 3- D body wave velocity structure is obtained by tomographic inversion down to the subducted slab. In the framework of Fondecyt 1050758, GeoAzur-IRD and ACT-18 projects, 35 broadband and short period instruments, were deployed in the studied zone for 135 days recording in continuous mode. At this zone the Andean active volcanism reappears after a gap of volcanic activity since late Miocene occurring north of 33 S due to the Central Chile flat slab subduction zone. Crustal seismicity in the depth range 0-30 km is well correlated with known geological faults that become now important in the assessment of the regional seismic hazard. This seismicity also clusters around the giant porphyry cooper deposits in the region (Rio Blanco, El Teniente), and are neither related to mine-blasts nor induced by mining activity. Moreover, the local 3-D velocity structure shows that the zone surrounding each deposit is characterized by high Vp/Vs greater than 1.8, which may indicate fluid phases located in the weakest and more fractured zone of the crust. The body wave velocity pattern shown at depth by the local tomography indicates channels of high Vp/Vs connecting the subducted slab with the surface at places where active volcanism is present, suggesting upward migration of hydrous or melted rocks. This pattern agrees with the one observed with a previous regional tomography that includes this zone, while this Vp/Vs pattern tends to be horizontal at the flat slab zone. At depths of 20-25 km, a layer of high Vp/Vs is observed beneath the Andes Cordillera that could be associated to changes in the rheological properties between the upper and lower crust, or to accumulation of magma. The average stress tensor, derived from focal mechanisms, indicate that the Andean zone is under compression in the plate convergence direction.

T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection.

PubMed

Mutnal, Manohar B; Schachtele, Scott J; Hu, Shuxian; Lokensgard, James R

2013-07-31

Highly active antiretroviral therapy (HAART) restores inflammatory immune responses in AIDS patients which may unmask previous subclinical infections or paradoxically exacerbate symptoms of opportunistic infections. In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune reconstitution inflammatory syndrome (IRIS). Here we describe a reliable mouse model to study underlying immunopathological mechanisms of CNS-IRIS. Utilizing our HSV brain infection model and mice with MAIDS, we investigated the effect of immune reconstitution on MAIDS mice harboring opportunistic viral brain infection. Using multi-color flow cytometry, we quantitatively measured the cellular infiltrate and microglial activation. Infection with the LP-BM5 retroviral mixture was found to confer susceptibility to herpes simplex virus (HSV)-1 brain infection to normally-resistant C57BL/6 mice. Increased susceptibility to brain infection was due to severe immunodeficiency at 8 wks p.i. and a marked increase in programmed death-1 (PD-1) expression on CD4+ and CD8+ T-cells. Both T-cell loss and opportunistic brain infection were associated with high level PD-1 expression because PD-1-knockout mice infected with LP-BM5 did not exhibit lymphopenia and retained resistance to HSV-1. In addition, HSV-infection of MAIDS mice stimulated peripheral immune cell infiltration into the brain and its ensuing microglial activation. Interestingly, while opportunistic herpes virus brain infection of C57BL/6 MAIDS mice was not itself lethal, when T-cell immunity was reconstituted through adoptive transfer of virus-specific CD3+ T-cells, it resulted in significant mortality among recipients. This immune reconstitution-induced mortality was associated with exacerbated neuroinflammation, as determined by MHC class II expression on resident microglia and elevated levels of Th1 cytokines in the brain. Taken together, these results indicate development of an immune reconstitution disease within the central nervous system (CNS-IRD). Experimental immune reconstitution disease of the CNS using T-cell repopulation of lymphopenic murine hosts harboring opportunistic brain infections may help elucidate neuroimmunoregulatory networks that produce CNS-IRIS in patients initiating HAART.

Conflicts between urbanization and agricultural activity in the outlying districts of Beni Mellal

NASA Astrophysics Data System (ADS)

Kehal, Driss; El makssoudi, Aziz

2017-04-01

On 13 May 2016, the IRD and the AviTem - Villa Méditerranée organized an international meeting in Marseilles, within the framework of "villes en question". This innovative pedagogical project has mobilized high school students from both sides of the Mediterranean (France, Algeria, Morocco, Tunisia). Accompanied by researchers, mediators and their teachers, they were introduced throughout the school year to the scientific approach. Their objective: to carry out surveys to decipher social links in the neighborhoods of their city. Highlight of the project, the international meeting, labeled by the Grand Tour, is held at the Villa Méditerranée. It enabled the 180 participants (high school students, teachers, researchers, partners) to discuss the question of how urban residents live together, a key issue for our urban societies in the 21st century. This international meeting on social ties in neighborhoods in the Mediterranean was an opportunity for high school students to present their surveys and share their experiences. They also exchanged views with a jury made up of representatives from the world of research and education, who awarded the "Villes en question" prize, which was again in favor of the health and environment club of Al Amria high school for the second consecutive year. The topic we discussed is: "Conflicts between urbanization and agricultural activity in the outlying districts of Beni Mellal". Six scrupulously selected science students traveled to Marseilles with 2 life sciences and earth teachers. Indeed, Béni Mellal, a city in central Morocco, has experienced in recent years the phenomenon of urbanization which has resulted in an expansion of the territory of the city to the peripheral zones in which there remain agricultural areas. How is this coexistence and this evolution experienced by the inhabitants? Students conducted on-site investigations. They were particularly interested in the representations, perceptions and practices of the inhabitants. They also interviewed a number of administrative and political leaders. They presented their research work in the form of an illustrated 180-second slideshow.

Impact of the Agulhas Return Current on the glacial Subantarctic region in the South Indian Ocean

NASA Astrophysics Data System (ADS)

Ikehara, M.; Crosta, X.; Manoj, M. C.

2017-12-01

The Southern Ocean has played an important role in the evolution of the global climate system. The Southern Ocean circulation is dominated by the Antarctic Circumpolar Current (ACC), the world's longest and largest current system. Sea ice coverage on sea surface strongly affects the climate of the Southern Hemisphere through its impacts on the energy and gas budget, on the atmospheric circulation, on the hydrological cycle, and on the biological productivity. The Agulhas Return Current (ARC) originates from the Agulhas Current, the major western boundary current in the Indian Ocean, and transports heat from subtropical to subantarctic region. It's thought that the Agulhas leakage from the Indian Ocean to the Atlantic was reduced for the last glacial due to a northward shift of the westerlies and ACC, however, there are still unknown yet how the ARC was responded to the reduced Agulhas leakage. A piston core DCR-1PC was collected from the Del Caño Rise (46°S, 44°E, 2632m), Indian sector of the Southern Ocean. Core site located in the Subantarctic region between the Subtropical Front (STF) and Subantarctic Front (SAF). Age model of the core was established by radiocarbon dating of planktic foraminifer Globorotalia bulloides and oxygen isotope stratigraphy of benthic foraminifers Cibicidoides wuellerstorfi and Melonis bareelanus. Sediment of DCR-1PC show the cyclic changes of diatom/carbonate ooze sedimentation corresponding to Southern Ocean fronts' migrations on glacial-interglacial timescales. Records of ice-rafted debris (IRD) and oxygen isotope in planktic foraminfer G. bulloides suggest that the melting of sea ice was significantly increased during the last glacial maximum (LGM) in the Subantarctic surface water. Diatom assemblage based summer SST also shows the relative warmer condition in the Subantarctic during the LGM. These results might be explained by the strong influence of the Agulhas Return Current during the LGM in the Subantarctic. The reduced Agulhas leakage due to a northward shift of the westerlies and ACC impacted significantly on sea ice melting in the glacial Subantarctic region in the South Indian Ocean.

Post-glacial variations of sea ice cover and river discharge in the western Laptev Sea (Arctic Ocean) - a high-resolution study over the last 18 ka

NASA Astrophysics Data System (ADS)

Hörner, Tanja; Stein, Ruediger; Fahl, Kirsten

2015-04-01

Here, we provide a high-resolution reconstruction of sea-ice cover variations in the western Laptev Sea, a crucial area in terms of sea-ice production in the Arctic Ocean and a region characterized by huge river discharge. Furthermore, the shallow Laptev Sea was strongly influenced by the post-glacial sea-level rise that should also be reflected in the sedimentary records. The sea Ice Proxy IP25 (Highly-branched mono-isoprenoid produced by sea-ice algae; Belt et al., 2007) was measured in two sediment cores from the western Laptev Sea (PS51/154, PS51/159) that offer a high-resolution composite record over the last 18 ka. In addition, sterols are applied as indicator for marine productivity (brassicasterol, dinosterol) and input of terrigenous organic matter by river discharge into the ocean (campesterol, ß-sitosterol). The sea-ice cover varies distinctly during the whole time period and shows a general increase in the Late Holocene. A maximum in IP25 concentration can be found during the Younger Dryas. This sharp increase can be observed in the whole circumarctic realm (Chukchi Sea, Bering Sea, Fram Strait and Laptev Sea). Interestingly, there is no correlation between elevated numbers of ice-rafted debris (IRD) interpreted as local ice-cap expansions (Taldenkova et al. 2010), and sea ice cover distribution. The transgression and flooding of the shelf sea that occurred over the last 16 ka in this region, is reflected by decreasing terrigenous (riverine) input, reflected in the strong decrease in sterol (ß-sitosterol and campesterol) concentrations. References Belt, S.T., Massé, G., Rowland, S.J., Poulin, M., Michel, C., LeBlanc, B., 2007. A novel chemical fossil of palaeo sea ice: IP25. Organic Geochemistry 38 (1), 16e27. Taldenkova, E., Bauch, H.A., Gottschalk, J., Nikolaev, S., Rostovtseva, Yu., Pogodina, I., Ya, Ovsepyan, Kandiano, E., 2010. History of ice-rafting and water mass evolution at the northern Siberian continental margin (Laptev Sea) during Late Glacial and Holocene times. Quaternary Science Reviews 29 (27-28), 3919-3935.

High-resolution record of last post-glacial variations of sea-ice cover and river discharge in the western Laptev Sea (Arctic Ocean)

NASA Astrophysics Data System (ADS)

Stein, R. H.; Hörner, T.; Fahl, K.

2014-12-01

Here, we provide a high-resolution reconstruction of sea-ice cover variations in the western Laptev Sea, a crucial area in terms of sea-ice production in the Arctic Ocean and a region characterized by huge river discharge. Furthermore, the shallow Laptev Sea was strongly influenced by the post-glacial sea-level rise that should also be reflected in the sedimentary records. The sea Ice Proxy IP25 (Highly-branched mono-isoprenoid produced by sea-ice algae; Belt et al., 2007) was measured in two sediment cores from the western Laptev Sea (PS51/154, PS51/159) that offer a high-resolution composite record over the last 18 ka. In addition, sterols are applied as indicator for marine productivity (brassicasterol, dinosterol) and input of terrigenous organic matter by river discharge into the ocean (campesterol, ß-sitosterol). The sea-ice cover varies distinctly during the whole time period and shows a general increase in the Late Holocene. A maximum in IP25 concentration can be found during the Younger Dryas. This sharp increase can be observed in the whole circumarctic realm (Chukchi Sea, Bering Sea, Fram Strait and Laptev Sea). Interestingly, there is no correlation between elevated numbers of ice-rafted debris (IRD) interpreted as local ice-cap expansions (Taldenkova et al. 2010), and sea ice cover distribution. The transgression and flooding of the shelf sea that occurred over the last 16 ka in this region, is reflected by decreasing terrigenous (riverine) input, reflected in the strong decrease in sterol (ß-sitosterol and campesterol) concentrations. ReferencesBelt, S.T., Massé, G., Rowland, S.J., Poulin, M., Michel, C., LeBlanc, B., 2007. A novel chemical fossil of palaeo sea ice: IP25. Organic Geochemistry 38 (1), 16e27. Taldenkova, E., Bauch, H.A., Gottschalk, J., Nikolaev, S., Rostovtseva, Yu., Pogodina, I., Ya, Ovsepyan, Kandiano, E., 2010. History of ice-rafting and water mass evolution at the northern Siberian continental margin (Laptev Sea) during Late Glacial and Holocene times. Quaternary Science Reviews 29 (27-28), 3919-3935.

Sedimentological fingerprint of modern and ancient meltwater outbursts across Antarctic continental shelves and slopes

NASA Astrophysics Data System (ADS)

Anderson, J. B.; Simkins, L. M.; Prothro, L. O.

2016-12-01

On formerly glaciated Antarctic continental shelves, the crystalline inner shelf is commonly dissected by linked subglacial lake and channel systems; however, signatures of meltwater are rare within subglacial and glacial-marine deposits on the middle to outer continental shelf. Recent observations of ice-marginal landforms incised by meltwater channels in the western Ross Sea indicate pulses of meltwater outbursts at marine-based grounding lines during deglaciation of the continental shelf. Here we present sedimentological evidence of meltwater outbursts and associated plumes from new and legacy cores collected on the continental shelf and slope within the Ross Sea, Amundsen Sea, and Marguerite Bay. Discrete fine-grained silt deposits are found overlying till and within proximal grounding line deposits and open-marine diatomaceous sediments. The deposits are massive to laminated, contain little to no coarser material, moderately sorted and dominated by a 10 μm grain-size mode. Grain-size measurements show no indication of winnowing; therefore, we interpret these deposits as meltwater deposits, transported by subglacial meltwater drainage systems to the grounding line and dispersed further seaward by meltwater plumes. The similarity of the deposits down-core and between shelf and slope sites within the Ross Sea, Amundsen Sea, and Marguerite Bay indicate that sorting and/or production of the fine silts occurs due to subglacial hydrodynamic processes. These distinctive meltwater deposits within the stratigraphic record provide an accessible proxy for identifying meltwater discharge from the Antarctic Ice Sheet and potentially be used to correlate cores on and off the continental shelf. Dating events on the continental shelf is notoriously difficult; therefore, deeper ocean records offer an easier means of bracketing the timing of meltwater discharge events. Longer records of ice dynamics from off the continental shelf are commonly used to reconstruct IRD records, and now can be used to reconstruct meltwater discharge histories, perhaps even extending back to warmer periods when the Antarctic Ice Sheet was a more temperate system that experienced seasonal surface melt, similar to the modern Greenland Ice Sheet.

Air temperature, radiation budget and area changes of Quisoquipina glacier in the Cordillera Vilcanota (Peru)

NASA Astrophysics Data System (ADS)

Suarez, Wilson; Macedo, Nicolás; Montoya, Nilton; Arias, Sandro; Schauwecker, Simone; Huggel, Christian; Rohrer, Mario; Condom, Thomas

2015-04-01

The Peruvian Andes host about 71% of all tropical glaciers. Although several studies have focused on glaciers of the largest glaciered mountain range (Cordillera Blanca), other regions have received little attention to date. In 2011, a new program has been initiated with the aim of monitoring glaciers in the centre and south of Peru. The monitoring program is managed by the Servicio Nacional de Meteorología e Hidrología del Perú (SENAMHI) and it is a joint project together with the Universidad San Antonio Abad de Cusco (UNSAAC) and the Autoridad Nacional del Agua (ANA). In Southern Peru, the Quisoquipina glacier has been selected due to its representativeness for glaciers in the Cordillera Vilcanota considering area, length and orientation. The Cordillera Vilcanota is the second largest mountain range in Peru with a glaciated area of approximately 279 km2 in 2009. Melt water from glaciers in this region is partly used for hydropower in the dry season and for animal breeding during the entire year. Using Landsat 5 images, we could estimate that the area of Quisoquipina glacier has decreased by approximately 11% from 3.66 km2 in 1990 to 3.26 km2 in 2010. This strong decrease is comparable to observations of other tropical glaciers. In 2011, a meteorological station has been installed on the glacier at 5180 m asl., measuring air temperature, wind speed, relative humidity, net short and longwave radiation and atmospheric pressure. Here, we present a first analysis of air temperature and the radiation budget at the Quisoquipina glacier for the first three years of measurements. Additionally, we compare the results from Quisoquipina glacier to results obtained by the Institut de recherche pour le développement (IRD) for Zongo glacier (Bolivia) and Antizana glacier (Ecuador). For both, Quisoquipina and Zongo glacier, net shortwave radiation may be the most important energy source, thus indicating the important role of albedo in the energy balance of the glacier surface. This indicates the importance of understanding the role of snow cover in ablation processes of tropical glaciers.

[Specific growth rate and the rate of energy metabolism in the ontogenesis of axolotl, Ambystoma mexicanum (Amphibia: Ambystomatidae)].

PubMed

Vladimirova, I G; Kleĭmenov, S Iu; Alekseeva, T A; Radzinskaia, L I

2003-01-01

Concordant changes in the rate of energy metabolism and specific growth rate of axolotls have been revealed. Several periods of ontogeny are distinguished, which differ in the ratio of energy metabolism to body weight and, therefore, are described by different allometric equations. It is suggested that the specific growth rate of an animal determines the type of dependence of energy metabolism on body weight.

Self-rated literacy level does not explain educational differences in health and disease

PubMed Central

2014-01-01

Background Although literacy is increasingly considered to play a role in socioeconomic inequalities in health, its contribution to the explanation of educational differences in health has remained unexplored. The aim of this study was to investigate the contribution of self-rated literacy to educational differences in health. Methods Data was collected from the Healthy Foundation and Lifestyle Segmentation Dataset (n = 4257). Self-rated literacy was estimated by individuals’ self-reported confidence in reading written English. We used logistic regression analyses to assess the association between educational level and health (long term conditions and self-rated health). Self-rated literacy and other potential explanatory variables were separately added to each model. For each added variable we calculated the percentage change in odds ratio to assess the contribution to the explanation of educational differences in health. Results People with lower educational attainment level were more likely to report a long term condition (OR 2.04, CI 1.80-2.32). These educational differences could mostly be explained by age (OR decreased by 27%) and could only minimally be explained by self-rated literacy, as measured by self-rated reading skills (OR decreased by 1%). Literacy could not explain differences in cardiovascular condition or diabetes, and only minimally contributed to mental health problems and depression (OR decreased by 5%). The odds of rating ones own health more negatively was higher for people with a low educational level compared to those with a higher educational level (OR 1.83, CI 1.59-2.010), self-rated literacy decreased the OR by 7%. Conclusion Measuring self-rated reading skills does not contribute significantly to the explanation of educational differences in health and disease. Further research should aim for the development of objective generic and specific instruments to measure health literacy skills in the context of health care, disease prevention and health promotion. Such instruments are not only important in the explanation of educational differences in health and disease, but can also be used to identify a group at risk of poorer health through low basic skills, enabling health services and health information to be targeted at those with greater need. PMID:24872884

Strain rate dependent calcite microfabric evolution at natural conditions

NASA Astrophysics Data System (ADS)

Rogowitz, Anna; Grasemann, Bernhard; Huet, Benjamin; Habler, Gerlinde

2014-05-01

Crystal plastic deformational behaviour of calcite has been the focus of many experimental studies. Different strain rates, pressure and temperature conditions have been addressed to investigate a wide range of deformation regimes. However, a direct comparison with natural fault rocks remains difficult because of extreme differences between experimental and natural strain rates. A flanking structure developed in almost pure calcite marble on Syros (Cyclades, Greece). Due to rotation of a planar feature (crack) a heterogeneous strain field in the surrounding area occurred resulting in different strain domains and the formation of the flanking structure. Assuming that deformation was active continuously during the development of the flanking structure, the different strain domains correspond to different strain-rate domains. The outcrop thus represents the final state of a natural experiment and gives us a great opportunity to get natural constraints on strain rate dependent deformation behaviour of calcite. Comparing the microfabrics in the 1 to 2.5 cm thick shear zone and the surrounding host rocks, which formed under the same metamorphic conditions but with different strain rates, is the central focus of this study. Due to the extreme variation in strain and strain rate, different microstructures and textures can be observed corresponding to different deformation mechanisms. With increasing strain rate we observe a change in dominant deformation mechanism from dislocation glide to dislocation creep and finally diffusion creep. Additionally, a change from subgrain rotation to bulging recrystallization can be observed in the dislocation creep regime. Crystallographic preferred orientations (CPO) and the grade of intracrystalline deformation were measured on a FEI Quanta 3D FEG instrument equipped with an EDAX Digiview IV EBSD camera. At all strain rates clear CPOs developed leading to the assumption that calcite preferentially deforms within the dislocation creep field. However, we can also find clear evidence for grain size sensitive deformation mechanisms at smaller grain sizes (3.6 μm) consistent with experimental observations and determined flaw laws. The results of this study are compared with experimental data, closing the gap between experimental and natural geological strain rates.

Effects of triploidy incidence on clinical outcomes for IVF-ET cycles in different ovarian stimulation protocols.

PubMed

Li, Mingzhao; Xue, Xia; Zhang, Silin; Li, Wei; Zhao, Xiaoli; Ren, Wenjuan; Shi, Juanzi

2015-10-01

To discuss the relationship between triploidy incidence and clinical outcomes of embryos derived from normally fertilized oocytes from the same cohort for in vitro fertilization-embryo transfer (IVF-ET) cycles in different ovarian stimulation protocol. This study included 2070 in vitro fertilization (IVF) cycles with long-term protocol, 802 IVF cycles with ultra short-term protocol and 508 IVF-D (in vitro fertilization by donor semen) cycles with long-term protocol from January 2013 to September 2014. According to the different 3PN rate, patients were divided into three groups as follows: Group 1 included patients with 0% 3PN zygotes, Group 2 included patients with 1-25% 3PN zygotes and Group 3 included patients with >25% 3PN zygotes. female age, no. of retrieved oocytes, normal fertilization rate, day-3 grade I + II embryos rate, day-3 grade I + II + III embryos rate, implantation rate, pregnancy rate and early abortion rate. Triploidy cycle incidence rate in IVF and IVF-D cycles with long-term protocol were significantly higher than in IVF cycles with ultra short-term protocol (p < 0.001). Triploidy fertilization rate found no significant difference between the three groups (p > 0.05). In three protocols, normal fertilization rate in 3PN = 0% and 3PN = 1-25% groups were significantly higher compared to 3PN > 25% group (p < 0.001). In IVF cycles with long-term protocol, the day-3 grade I + II embryos, implantation and pregnancy rate in 3PN > 25% group were significantly lower than other two groups (p < 0.05). The day-3 grade I + II + III embryos and early abortion rate found no significant difference between the three groups (p > 0.05). In IVF cycles with ultra short-term protocol, there were no significant differences found in day-3 grade I + II embryos, day-3 grade I + II + III embryos, implantation, pregnancy and early abortion rate (p > 0.05). In IVF-D cycles with long-term protocol, the day-3 grade I + II embryos, day-3 grade I + II + III embryos and implantation rate in 3PN > 25% group were significantly lower than other two groups (p < 0.05). The pregnancy and early abortion rates found no significant difference in the three groups (p > 0.05). We observed that high proportion of triploid zygotes made a negative effect on clinical outcomes for IVF-ET cycles with long-term protocol.

Is sexual concordance related to awareness of physiological states?

PubMed

Suschinsky, Kelly D; Lalumière, Martin L

2012-02-01

Sexual concordance refers to the degree to which two aspects of human sexual arousal (genital response and self-reported sexual arousal) correspond with each other. Researchers have consistently reported a sex difference in sexual concordance: The relationship between genital responses and reported feelings of sexual arousal in men is positive and large, whereas the relationship in women is positive but much smaller than that seen in men. The study of interoception--people's awareness of their physiological states--reveals a similar sex difference: Men are more aware of a variety of (non-genital) responses (e.g., heart rate) than women in the laboratory. The purpose of the current study was to investigate whether the sex difference in sexual concordance was related to a broader sex difference in interoception. Twenty men and 20 women were presented with twelve 90 s sexual and non-sexual film clips while their genital responses, heart rate, and respiration rate were measured. Participants also estimated their physiological responses. As expected, men were significantly more sexually concordant than women. Men were also significantly more aware of their heart rate, but there was no significant sex difference in respiration rate awareness. Sexual concordance was not significantly correlated with either heart rate or respiration rate awareness. The results suggest that the sex difference in sexual concordance may be a unique phenomenon, separate from general awareness of physiological states.

Impact of Business Cycles on US Suicide Rates, 1928–2007

PubMed Central

Florence, Curtis S.; Quispe-Agnoli, Myriam; Ouyang, Lijing; Crosby, Alexander E.

2011-01-01

Objectives. We examined the associations of overall and age-specific suicide rates with business cycles from 1928 to 2007 in the United States. Methods. We conducted a graphical analysis of changes in suicide rates during business cycles, used nonparametric analyses to test associations between business cycles and suicide rates, and calculated correlations between the national unemployment rate and suicide rates. Results. Graphical analyses showed that the overall suicide rate generally rose during recessions and fell during expansions. Age-specific suicide rates responded differently to recessions and expansions. Nonparametric tests indicated that the overall suicide rate and the suicide rates of the groups aged 25 to 34 years, 35 to 44 years, 45 to 54 years, and 55 to 64 years rose during contractions and fell during expansions. Suicide rates of the groups aged 15 to 24 years, 65 to 74 years, and 75 years and older did not exhibit this behavior. Correlation results were concordant with all nonparametric results except for the group aged 65 to 74 years. Conclusions. Business cycles may affect suicide rates, although different age groups responded differently. Our findings suggest that public health responses are a necessary component of suicide prevention during recessions. PMID:21493938

Reconciling extreme branch length differences: decoupling time and rate through the evolutionary history of filmy ferns.

PubMed

Schuettpelz, Eric; Pryer, Kathleen M

2006-06-01

The rate of molecular evolution is not constant across the Tree of Life. Characterizing rate discrepancies and evaluating the relative roles of time and rate along branches through the past are both critical to a full understanding of evolutionary history. In this study, we explore the interactions of time and rate in filmy ferns (Hymenophyllaceae), a lineage with extreme branch length differences between the two major clades. We test for the presence of significant rate discrepancies within and between these clades, and we separate time and rate across the filmy fern phylogeny to simultaneously yield an evolutionary time scale of filmy fern diversification and reconstructions of ancestral rates of molecular evolution. Our results indicate that the branch length disparity observed between the major lineages of filmy ferns is indeed due to a significant difference in molecular evolutionary rate. The estimation of divergence times reveals that the timing of crown group diversification was not concurrent for the two lineages, and the reconstruction of ancestral rates of molecular evolution points to a substantial rate deceleration in one of the clades. Further analysis suggests that this may be due to a genome-wide deceleration in the rate of nucleotide substitution.

Influence of plant communities on denitrification in a tidal freshwater marsh of the Potomac River, United States.

PubMed

Hopfensperger, Kristine N; Kaushal, Sujay S; Findlay, Stuart E G; Cornwell, Jeffrey C

2009-01-01

We investigated whether marsh surface elevation, plant community composition (annuals vs. perennials), and organic matter quantity/quality were associated with differences in denitrification rates in an urban tidal freshwater marsh of the Potomac River, United States. We measured denitrification rates using both denitrification enzyme activity (DEA) with acetylene inhibition (June: n = 38, 3234 +/- 303; October: n = 38, 1557 +/- 368 ng N g dry soil(-1) h(-1)) and direct N(2) flux measurements with membrane inlet mass spectrometry (MIMS) (November: n = 6, 147 +/- 24 mumol m(-2) h(-1)). Organic carbon content and nitrate concentrations in soil, and plant community composition were correlated with elevation, but DEA rates did not differ across marsh surface elevation. Soil organic carbon was highest in plots dominated by perennial graminoids, but DEA rates did not differ across plant community types. The DEA rates increased with increasing soil ammonium concentrations and total N content, and DEA rates differed between summer and fall sampling. The MIMS rates did not differ across plant community types, but were correlated with soil organic N content. Denitrification rates suggest that potential N removal at the site could be substantial. In addition, denitrification rates measured in Dyke Marsh were higher than rates for sediments measured in the adjacent Potomac River. Tidal freshwater marshes can represent an important site for denitrification, and factors fostering denitrification should be considered when restoring urban tidal freshwater wetlands as they are faced with pressures from increasing land use change and sea level rise.

Gender and age differences in components of traffic-related pedestrian death rates: exposure, risk of crash and fatality rate.

PubMed

Onieva-García, María Ángeles; Martínez-Ruiz, Virginia; Lardelli-Claret, Pablo; Jiménez-Moleón, José Juan; Amezcua-Prieto, Carmen; de Dios Luna-Del-Castillo, Juan; Jiménez-Mejías, Eladio

2016-12-01

This ecological study aimed i) to quantify the association of age and gender with the three components of pedestrians' death rates after a pedestrian-vehicle crash: exposure, risk of crash and fatality, and ii) to determine the contribution of each component to differences in death rates according to age and gender in Spain. We analyzed data for 220 665 pedestrians involved in road crashes recorded in the Spanish registry of road crashes with victims from 1993 to 2011, and a subset of 39 743 pedestrians involved in clean collisions (in which the pedestrian did not commit an infraction). Using decomposition and quasi-induced exposure methods, we obtained the proportion of increase in death rates for each age and gender group associated with exposure, risk of collision and fatality. Death rates increased with age. The main contributor to this increase was fatality, although exposure also increased with age. In contrast, the risk of collision decreased with age. Males had higher death rates than females, especially in the 24-54 year old group. Higher fatality rates in males were the main determinant of this difference, which was also related with a higher risk of collision in males. However, exposure rates were higher in females. The magnitude and direction of the associations between age and gender and each of the three components of pedestrians' death rates differed depending on the specific component explored. These differences need to be taken into account in order to prioritize preventive strategies intended to decrease mortality among pedestrians.

Gender and age differences in components of traffic-related pedestrian death rates: exposure, risk of crash and fatality rate.

PubMed

Onieva-García, María Ángeles; Martínez-Ruiz, Virginia; Lardelli-Claret, Pablo; Jiménez-Moleón, José Juan; Amezcua-Prieto, Carmen; de Dios Luna-Del-Castillo, Juan; Jiménez-Mejías, Eladio

This ecological study aimed i) to quantify the association of age and gender with the three components of pedestrians' death rates after a pedestrian-vehicle crash: exposure, risk of crash and fatality, and ii) to determine the contribution of each component to differences in death rates according to age and gender in Spain. We analyzed data for 220 665 pedestrians involved in road crashes recorded in the Spanish registry of road crashes with victims from 1993 to 2011, and a subset of 39 743 pedestrians involved in clean collisions (in which the pedestrian did not commit an infraction). Using decomposition and quasi-induced exposure methods, we obtained the proportion of increase in death rates for each age and gender group associated with exposure, risk of collision and fatality. Death rates increased with age. The main contributor to this increase was fatality, although exposure also increased with age. In contrast, the risk of collision decreased with age. Males had higher death rates than females, especially in the 24-54 year old group. Higher fatality rates in males were the main determinant of this difference, which was also related with a higher risk of collision in males. However, exposure rates were higher in females. The magnitude and direction of the associations between age and gender and each of the three components of pedestrians' death rates differed depending on the specific component explored. These differences need to be taken into account in order to prioritize preventive strategies intended to decrease mortality among pedestrians.

How do stakeholder groups vary in a Delphi technique about primary mental health care and what factors influence their ratings?

PubMed

Campbell, S M; Shield, T; Rogers, A; Gask, L

2004-12-01

While mental health is a core part of primary care, there are few validated quality measures and little relevant internationally published research. Consensus panel methods are a useful means of developing quality measures where evidence is sparse and/or opinions are diverse. However, little is known about the dynamics of consensus techniques and the factors that influence the judgements and ratings of panels and individual panelists. (1) To describe differences in panel ratings on the quality of primary mental health care services by patient, carer, professional and managerial panels within a Delphi procedure; and (2) to explore why different panels and panelists rate quality indicators of primary mental health care differently. Two round postal Delphi technique and exploratory semi-structured interviews. 115 panelists across 11 panels. Eleven panelists were subsequently interviewed. 87 of 334 indicators (26%) were rated face valid by all 11 panels. There was little disagreement within panel ratings but significant differences between panels. The GP panel rated the least number of indicators valid (n = 138, 41%) and carers the most (n = 304, 91%). The way in which panelists interpreted and conceptualised the indicators and their definition of quality of mental health care affected the way in which participants made their ratings. Stakeholders in primary mental health care have diverse views of quality of care and these differences translate into how they rate quality indicators. Exploratory interviews suggest that ratings are influenced by past experience, expectations, definitions of quality of care, and perceived power relationships between stakeholders.

Sex differences in self-estimates of lay dimensions of intelligence.

PubMed

Furnham, A

1999-08-01

260 participants rated themselves on 12 items that made up the three types of intelligence as noted by Sternberg, et al. in 1981. There were sex differences on two of the three standardized scores with men rating themselves higher than women on practical and verbal intelligence. This confirms previous studies of sex differences in the ratings of over-all (g) and multiple intelligences.

34 CFR 222.68 - What tax rates does the Secretary use if two or more different classifications of real property...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What tax rates does the Secretary use if two or more different classifications of real property are taxed at different rates? 222.68 Section 222.68 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION...

Differences between Workers on Different Shifts in Rating of Client Skills.

ERIC Educational Resources Information Center

Gampel, Ezra S.

The study sought to determine if there are differences between shifts of workers in Intermediate Care Facilities in their ratings of the daily living skills of mentally retarded residents, and whether these differences reflect actual differences in performance by the residents. Staff were interviewed concerning the level of prompt required to…

Analysis and Long-Term Follow-Up of the Surgical Treatment of Children With Craniopharyngioma.

PubMed

Cheng, Jing; Shao, Qiang; Pan, Zhiyong; You, Jin

2016-11-01

To investigate the relationship between the operative approach, clinical pathological factors, and curative effect of the surgical treatment in the patients with craniopharyngioma; to provide a theoretical basis for determining the prognosis and reducing the recurrence rate during the long-term postoperative follow-up in children. This was a retrospective analysis of the clinical data of 92 children who underwent surgical treatment in our department from May 2011 to January 2005. Long-term follow-up was performed from 12 months to 8 years. The pterional approach was used in 49 patients, the interhemispheric approach in 20 patients, the corpus callosum approach in 16 patients, and the butterfly approach in 7 patients. Pathological classification was performed by hematoxylin and eosin stain staining of the pathological tissues and evaluated according to the different surgical approaches, MRI calcification status, calcification type, pathological type, whether radiotherapy was performed, postoperative recurrence, and death. For the pterion approach resection, there was near total resection in 46 patients (93.9%) with the lowest recurrence rate. The operative approach and postoperative recurrence rates were compared; the difference was statistically significant (P <0.05). For comparison of the operative approach and postoperative mortality, the difference was not statistically significant (P >0.05). There was not a significant difference between the MRI classification and postoperative recurrence rate (P >0.05). Comparing the degree of tumor calcification with the recurrence rate after operation and the mortality rate, the difference was statistically significant (P <0.05). The recurrence rate and mortality rate of adamantimous craniopharyngioma and squamous papillary craniopharyngioma in 2 groups following operation were compared, and the differences were statistically significant (P <0.05). Postoperative adjuvant radiotherapy was compared with the postoperative recurrence rate and mortality; the differences were statistically significant (P <0.05). The main effects on tumor recurrence include the choice of surgical approach and degree of calcification. The adamantimous craniopharyngioma relapse rate is higher, which could be because invasion of craniopharyngioma only occurs with adamantimous craniopharyngioma. Postoperative radiotherapy can significantly prolong the recurrence time and reduce the mortality rate of patients with craniopharyngioma.

Relationship Between Metabolic Rate and Sea Depth in Bivalves and Gastropods

NASA Astrophysics Data System (ADS)

Ruiz, B. R.; Shih, B.; Heim, N.; Payne, J.

2016-12-01

The purpose of this study was to find and observe trends in the metabolic rate of bivalves and gastropod in regards to sea depth in order to see if all organisms follow a general trend for metabolism and to provide data to help future conservation efforts of these keystone organisms. Using geographic data produced by McClain et. al (2012) and body size data from Heim et. al (2015), the metabolic rate and sea depth data were plotted using the `R statistical software'. The Pearson correlation test was performed on each respective graph. Deep sea mollusks were considered those that resided at a water depth of 500 meters or deeper while shallow mollusks resided at a depth less than 500 meters. The gastropods showed positive correlations in the relationship between metabolic rate and ocean depth while bivalves showed a negative trend. When the metabolic rate versus minimum ocean depth was graphed, the graphs for deep bivalves and shallow gastropods returned bad p-values. From this data, it can be seen that water depth and metabolic rate have relationships, although different molluscan classes are adapted to their environments in different ways, as seen by the differences in the relationships between metabolic rates and ocean depth of the gastropods and bivalves. The results indicated that there is a general negative trend between metabolic rate and ocean depth of bivalves, and a positive relationship for gastropods. The difference in relationship in gastropods is thought to be attributed to the size trends of gastropods as they live in deeper waters, which is that gastropods increase in size across the bathyal region, and decrease as gastropods approach the extremely deep water. As displayed by the two different metabolic trends, this study shows the different ways molluscan classes have adapted to different evolutionary selection pressures.

Quality assessment and comparison of grading between examiners and supervisors of Bachelor theses in nursing education.

PubMed

Lundgren, Solveig M; Halvarsson, Maud; Robertsson, Barbro

2008-01-01

This study compares supervisors' and examiners' grading of quality of theses at Bachelor level in nursing. An instrument developed to asses the quality of theses was used. Eight aspects of quality were rated. One hundred and fifteen theses were rated by both examiner and supervisor. Significant correlations were found between examiners' and supervisors' ratings of all aspects of quality. Good agreement was found in 89-96% of the ratings on individual aspects of quality. The means of differences between ratings were small but significantly differed from zero in four out of eight aspects. In theses rated low for quality of language and formality, differences between examiners' and supervisors' ratings on all aspects of quality were significantly larger than in theses rated high for quality of language and formality. The general conclusion is that the evaluations made by examiners and by supervisors corresponded well. Differences found indicates that examiners in general give lower scores than supervisors especially on quality aspects that are most closely related to research methods and experiences. This study is part of a larger project that is investigating quality of theses and the student's attitudes and learning experiences of writing theses.

Effect of varying the pressurisation rate during noninvasive pressure support ventilation.

PubMed

Prinianakis, G; Delmastro, M; Carlucci, A; Ceriana, P; Nava, S

2004-02-01

The aim of the study was to assess the effects of varying the pressurisation rate during noninvasive pressure support ventilation on patients' breathing pattern, inspiratory effort, arterial blood gases, tolerance to ventilation and amount of air leakage. A total of 15 chronic obstructive pulmonary disease patients recovering from an acute episode of hypercapnic acute respiratory failure were studied during four randomised trials with different levels of pressurisation rate. No significant changes were observed in breathing pattern and arterial blood gases between the different runs. The pressure time product of the diaphragm, an estimate of its metabolic consumption, was significantly lower with all pressurisation rates than with spontaneous breathing, but was significantly lowest with the fastest rate. However, air leak, assessed by the ratio between expired and inspired tidal volumes, increased and the patients' tolerance of ventilation, measured using a standardised scale, was significantly poorer with the fastest pressurisation rate. In chronic obstructive pulmonary disease patients recovering from an episode of acute hypercapnic respiratory failure and ventilated with noninvasive pressure support ventilation, different pressurisation rates resulted in different reductions in the pressure time product of the diaphragm; this reduction was greater with the fastest rate, but was accompanied by significant air leaks and poor tolerance.

Effect of strain rate on bake hardening response of BH220 steel

NASA Astrophysics Data System (ADS)

Das, Anindya; Tarafder, Soumitro; Sivaprasad, S.; Chakrabarti, Debalay

2015-09-01

This study aims at understanding the bake hardening ability of ultra low carbon BH220 steel at different strain rates. The as-received material has been pre-strained to four different levels and then deformed in tension under (a) as pre-strained state and (b) after baking at 170 ∘C for 20 minutes, at three different strain rates of 0.001, 0.1 and 100/s. In both the conditions, yield stress increased with pre-strain and strain rate, but bake hardening ability was found to decrease when strain rate was increased. The strain rate sensitivity of the material was also found to decrease with bake hardening. Generation of dislocation forests and their subsequent immobility during baking treatment enables them to act as long range obstacles during further deformation. At higher strain rates, less amount of dislocations are produced which can interact with themselves and produce hardening, because of which bake hardening ability and the strain rate drops. A dislocation based strengthening model, as proposed by Larour et al. 2011 [7], was used to predict the yield stress values obtained at different conditions. The equation produced excellent co-relation with the experimental data.

No evidence of nonlinear effects of predator density, refuge availability, or body size of prey on prey mortality rates.

PubMed

Simkins, Richard M; Belk, Mark C

2017-08-01

Predator density, refuge availability, and body size of prey can all affect the mortality rate of prey. We assume that more predators will lead to an increase in prey mortality rate, but behavioral interactions between predators and prey, and availability of refuge, may lead to nonlinear effects of increased number of predators on prey mortality rates. We tested for nonlinear effects in prey mortality rates in a mesocosm experiment with different size classes of western mosquitofish ( Gambusia affinis ) as the prey, different numbers of green sunfish ( Lepomis cyanellus ) as the predators, and different levels of refuge. Predator number and size class of prey, but not refuge availability, had significant effects on the mortality rate of prey. Change in mortality rate of prey was linear and equal across the range of predator numbers. Each new predator increased the mortality rate by about 10% overall, and mortality rates were higher for smaller size classes. Predator-prey interactions at the individual level may not scale up to create nonlinearity in prey mortality rates with increasing predator density at the population level.

Price current-meter standard rating development by the U.S. geological survey

USGS Publications Warehouse

Hubbard, E.F.; Schwarz, G.E.; Thibodeaux, K.G.; Turcios, L.M.

2001-01-01

The U.S. Geological Survey has developed new standard rating tables for use with Price type AA and pygmy current meters, which are employed to measure streamflow velocity. Current-meter calibration data, consisting of the rates of rotation of meters at several different constant water velocities, have shown that the original rating tables are no longer representative of the average responsiveness of newly purchased meters or meters in the field. The new rating tables are based on linear regression equations that are weighted to reflect the population mix of current meters in the field and weighted inversely to the variability of the data at each calibration velocity. For calibration velocities of 0.3 m/s and faster, at which most streamflow measurements are made, the new AA-rating predicts the true velocities within 1.5% and the new pygmy-meter rating within 2.0% for more than 95% of the meters. At calibration velocities, the new AA-meter rating is up to 1.4% different from the original rating, and the new pygmy-meter rating is up to 1.6% different.

Differences of Articulation Rate and Utterance Length in Fluent and Disfluent Utterances of Preschool Children Who Stutter

PubMed Central

Chon, HeeCheong; Sawyer, Jean; Ambrose, Nicoline G.

2014-01-01

Purpose The purpose of this study was to investigate characteristics of four types of utterances in preschool children who stutter: perceptually fluent, containing normal disfluencies (OD utterance), containing stuttering-like disfluencies (SLD utterance), and containing both normal and stuttering-like disfluencies (SLD+OD utterance). Articulation rate and length of utterance were measured to seek the differences. Because articulation rate may reflect temporal aspects of speech motor control, it was predicted that the articulation rate would be different between perceptually fluent utterances and utterances containing disfluencies. The length of utterance was also expected to show different patterns. Method Participants were 14 preschool children who stutter. Disfluencies were identified from their spontaneous speech samples, and articulation rate in syllables per second and utterance length in syllables were measured for the four types of utterances. Results and discussion There was no significant difference in articulation rate between each type of utterance. Significantly longer utterances were found only in SLD+OD utterances compared to fluent utterances, suggesting that utterance length may be related to efforts in executing motor as well as linguistic planning. The SLD utterance revealed a significant negative correlation in that longer utterances tended to be slower in articulation rates. Longer utterances may place more demand on speech motor control due to more linguistic and/or grammatical features, resulting in stuttering-like disfluencies and a decreased rate. PMID:22995336

Risk behaviours and self rated health in Russia 1998

PubMed Central

Carlson, P

2001-01-01

OBJECTIVES—As self rated health and mortality represent different dimensions of public health and as risk behaviours have been closely related to mortality, we wanted to examine whether (poor) self rated health on the one hand and risk behaviours on the other can be attributed to different causes.
METHODS—The Taganrog household survey (1998) was conducted in the form of face to face interviews and included 1009 people and their families. To estimate health differences and differences in risk behaviours between groups, logistic regressions were performed.
RESULTS—In Taganrog between 1993/94 and 1998, changes in self rated health seem to have been much more dramatic than changes in smoking and different in direction from changes in heavy alcohol consumption. Moreover, self rated "poor" health was especially common among those whose economic situation was worse in 1998 than 10 years before. However, having a poorer economy during the period 1988-1998, does not seem to have affected drinking or smoking habits significantly.
CONCLUSIONS—Self rated health seems to be closely related to three indicators of economic circumstances. Risk behaviours are probably important for the poor state of public health in Russia, but may be less sensitive to the economic aspects of the transition than is self rated health.


Keywords: self rated health; risk behaviours PMID:11604437

Environmental and genetic influences on flight metabolic rate in the honey bee, Apis mellifera.

PubMed

Harrison, Jon F; Fewell, Jennifer H

2002-10-01

Flying honey bees demonstrate highly variable metabolic rates. The lowest reported values (approximately 0.3 Wg(-1)) occur in tethered bees generating the minimum lift to support their body weight, free-flying 2-day old bees, winter bees, or bees flying at high air temperatures (45 degrees C). The highest values (approximately 0.8 Wg(-1)) occur in foragers that are heavily loaded or flying in low-density air. In different studies, flight metabolic rate has increased, decreased, or remained constant with air temperature. Current research collectively suggests that this variation occurs because flight metabolic rates decrease at thorax temperatures above or below 38 degrees C. At 30 degrees C, approximately 30% of colonial energy is spent during typical foraging, so variation in flight metabolic rate can strongly affect colony-level energy balance. Higher air temperatures tend to increase colonial net gain rates, efficiencies and honey storage rates due to lower metabolic rates during flight and in the hive. Variation in flight metabolism has a clear genetic basis. Different genetic strains of honey bees often differ in flight metabolic rate, and these differences in flight physiology can be correlated with foraging effort, suggesting a possible pathway for selection effects on flight metabolism.

[Occupational hazards survey of specially supervised enterprises during 2011-2012 in one district of Shenzhen, China].

PubMed

Zhang, Hongsheng; Zhang, Xianxing; Zhang, Chu; Liu, Song; He, Jian-Feng

2014-04-01

To analyze the results of an occupational hazards survey of specially supervised enterprises (156 enterprise-times) during 2011-2012 in one district of Shenzhen, China and find out the changes in occupational hazards in these enterprises, and to put forward countermeasures for the prevention and control of occupational hazards. Occupational hazards monitoring results for specially supervised enterprises (156 enterprise-times) during 2011-2012 were included. Comparison and analysis were performed between different years, different industries, different occupational hazards, and different sizes of enterprises. A total of 1274 monitoring sites from these specially supervised enterprises were included, of which qualification rate was 73.55% (937/1274), and the noise monitoring sites showed the lowest qualification rate. The overall qualification rate in 2012 (70.37%) was significantly lower than that in 2011 (80.94%) (χ(2) = 15.38, P < 0.01). In electronics industry, the qualification rate in 2012 was significantly lower than that in 2011 (χ2 = 11.27, P = 0.001). Comparison of various hazards in different industries indicated that electronic enterprises and furniture enterprises had the lowest qualification rate in noise monitoring, printing enterprises had the lowest qualification rate in organic solvent monitoring, and furniture enterprises had the lowest qualification rate in dust monitoring. Comparison between different sizes of enterprises indicated that the qualification rate of large and medium enterprises in 2012 was significantly lower than that in 2011, while the qualification rate of small enterprises in 2012 was significantly higher than that in 2011 (P < 0.01 or P < 0.05). In the prevention and control of occupational hazards in specially supervised enterprises, special attention should be paid to the control of organic solvents in printing enterprises and noise and dust in furniture enterprises.

Dielectric recovery mechanism of pressurized carbon dioxide at liquid and supercritical phases

NASA Astrophysics Data System (ADS)

Tanoue, Hiroyuki; Furusato, Tomohiro; Imamichi, Takahiro; Ota, Miyuki; Katsuki, Sunao; Akiyama, Hidenori

2015-09-01

Estimates of dielectric recovery rates of supercritical (SC) and liquid carbon dioxide (CO2) were derived with focus on highly-repetitive pulsed power switching mediums. Calculated results suggest that recovery time of SC and liquid CO2 are approximately 50 times shorter than that of water and oils. Prior to 10 µs after breakdown, recovery rates in neither SC nor liquid CO2 reached 100%, though the recovery rate in SC CO2 was higher than that of liquid CO2. To examine causes of recovery rate differences, each dielectric recovery process in SC and liquid CO2 was observed by laser shadowgraph technique. These shadowgraph images suggest two factors explaining dielectric recovery rate differences between these medium conditions: 1) thermodynamic property differences between medium conditions, and 2) differences in the low density region recovery mechanism.

Experimental investigation of different regimes of mode-locking in a high repetition rate passively mode-locked semiconductor quantum-dot laser.

PubMed

Kéfélian, Fabien; O'Donoghue, Shane; Todaro, Maria Teresa; McInerney, John; Huyet, Guillaume

2009-04-13

We report experimental investigations on a two-section 16-GHz repetition rate InAs/GaAs quantum dot passively mode-locked laser. Near the threshold current, pseudo-periodic Q-switching with complex dynamics is exhibited. Mode-locking operation regimes characterized by different repetition rates and timing jitter levels are encountered up to twice the threshold current. Evolution of the RF spectrum and optical spectrum with current is compared. The different mode-locked regimes are shown to be associated with different spectral and temporal shapes, ranging from 1.3 to 6 ps. This point is discussed by introducing the existence of two different supermodes. Repetition rate evolution and timing jitter increase is attributed to the coupling between the dominant and the secondary supermodes.

Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU

PubMed Central

Li, Pei-Chun; Chen, Wei-I; Huang, Chih-Ming; Liu, Ching-Ju; Chang, Hsiu-wen; Lin, Hung-Ching

2016-01-01

Objectives To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevalence of hearing loss in neonatal population; and 4) try to find a practical newborn hearing screening time algorithm to reduce refer rate in NICU Materials and Methods It examined 15,624 newborns in the WBN (13,676) and NICU (1948) screened for congenital HL using AABR. The variables analyzed in it were the screening rate, referral rate, follow-up rate, diagnostic rate and diagnostic age, prevalence rate, degrees of congenital bilateral HL. The study was approved by the hospital’s institutional review board (13MMHISO23). Results The screening rates were 99.8% and 99.6% in the WBN and NICU groups, respectively, without significant difference. The referral rates were 0.7% and 2.8% in the WBN and NICU groups, with significant difference. Furthermore, the diagnostic follow-up rates were 76.7% and 89.1% in the WBN and NICU groups, without significant difference. The average initial diagnostic ages were 1.9 months and 3.8 months in the WBN and NICU groups, with significant difference. The prevalence of congenital bilateral hearing loss were 0.27% and 1.6% in the WBN and NICU groups, with significant difference. Conclusion The screening, referral and follow-up rate in the WBN and NICU groups were equivalent to the quality indicators. For NICU group, screening and diagnostic follow up were performed later than those in WBN group; however the lower referral rate in our NICU group was successfully achieved in this study and can be applied clinically. The prevalence of congenital bilateral hearing loss was higher in the NICU group than in the WBN group. PMID:27023324

Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU.

PubMed

Li, Pei-Chun; Chen, Wei-I; Huang, Chih-Ming; Liu, Ching-Ju; Chang, Hsiu-wen; Lin, Hung-Ching

2016-01-01

To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevalence of hearing loss in neonatal population; and 4) try to find a practical newborn hearing screening time algorithm to reduce refer rate in NICU. It examined 15,624 newborns in the WBN (13,676) and NICU (1948) screened for congenital HL using AABR. The variables analyzed in it were the screening rate, referral rate, follow-up rate, diagnostic rate and diagnostic age, prevalence rate, degrees of congenital bilateral HL. The study was approved by the hospital's institutional review board (13MMHISO23). The screening rates were 99.8% and 99.6% in the WBN and NICU groups, respectively, without significant difference. The referral rates were 0.7% and 2.8% in the WBN and NICU groups, with significant difference. Furthermore, the diagnostic follow-up rates were 76.7% and 89.1% in the WBN and NICU groups, without significant difference. The average initial diagnostic ages were 1.9 months and 3.8 months in the WBN and NICU groups, with significant difference. The prevalence of congenital bilateral hearing loss were 0.27% and 1.6% in the WBN and NICU groups, with significant difference. The screening, referral and follow-up rate in the WBN and NICU groups were equivalent to the quality indicators. For NICU group, screening and diagnostic follow up were performed later than those in WBN group; however the lower referral rate in our NICU group was successfully achieved in this study and can be applied clinically. The prevalence of congenital bilateral hearing loss was higher in the NICU group than in the WBN group.

Correlations Between Ratings on the Resident Annual Evaluation Summary and the Internal Medicine Milestones and Association With ABIM Certification Examination Scores Among US Internal Medicine Residents, 2013-2014.

PubMed

Hauer, Karen E; Vandergrift, Jonathan; Hess, Brian; Lipner, Rebecca S; Holmboe, Eric S; Hood, Sarah; Iobst, William; Hamstra, Stanley J; McDonald, Furman S

2016-12-06

US internal medicine residency programs are now required to rate residents using milestones. Evidence of validity of milestone ratings is needed. To compare ratings of internal medicine residents using the pre-2015 resident annual evaluation summary (RAES), a nondevelopmental rating scale, with developmental milestone ratings. Cross-sectional study of US internal medicine residency programs in the 2013-2014 academic year, including 21 284 internal medicine residents (7048 postgraduate-year 1 [PGY-1], 7233 PGY-2, and 7003 PGY-3). Program director ratings on the RAES and milestone ratings. Correlations of RAES and milestone ratings by training year; correlations of medical knowledge ratings with American Board of Internal Medicine (ABIM) certification examination scores; rating of unprofessional behavior using the 2 systems. Corresponding RAES ratings and milestone ratings showed progressively higher correlations across training years, ranging among competencies from 0.31 (95% CI, 0.29 to 0.33) to 0.35 (95% CI, 0.33 to 0.37) for PGY-1 residents to 0.43 (95% CI, 0.41 to 0.45) to 0.52 (95% CI, 0.50 to 0.54) for PGY-3 residents (all P values <.05). Linear regression showed ratings differed more between PGY-1 and PGY-3 years using milestone ratings than the RAES (all P values <.001). Of the 6260 residents who attempted the certification examination, the 618 who failed had lower ratings using both systems for medical knowledge than did those who passed (RAES difference, -0.9; 95% CI, -1.0 to -0.8; P < .001; milestone medical knowledge 1 difference, -0.3; 95% CI, -0.3 to -0.3; P < .001; and medical knowledge 2 difference, -0.2; 95% CI, -0.3 to -0.2; P < .001). Of the 26 PGY-3 residents with milestone ratings indicating deficiencies on either of the 2 medical knowledge subcompetencies, 12 failed the certification examination. Correlation of RAES ratings for professionalism with residents' lowest professionalism milestone ratings was 0.44 (95% CI, 0.43 to 0.45; P < .001). Among US internal medicine residents in the 2013-2014 academic year, milestone-based ratings correlated with RAES ratings but with a greater difference across training years. Both rating systems for medical knowledge correlated with ABIM certification examination scores. Milestone ratings may better detect problems with professionalism. These preliminary findings may inform establishment of the validity of milestone-based assessment.

Altering gender role expectations: effects on pain tolerance, pain threshold, and pain ratings.

PubMed

Robinson, Michael E; Gagnon, Christine M; Riley, Joseph L; Price, Donald D

2003-06-01

The literature demonstrating sex differences in pain is sizable. Most explanations for these differences have focused on biologic mechanisms, and only a few studies have examined social learning. The purpose of this study was to examine the contribution of gender-role stereotypes to sex differences in pain. This study used experimental manipulation of gender-role expectations for men and women. One hundred twenty students participated in the cold pressor task. Before the pain task, participants were given 1 of 3 instructional sets: no expectation, 30-second performance expectation, or a 90-second performance expectation. Pain ratings, threshold, and tolerance were recorded. Significant sex differences in the "no expectation" condition for pain tolerance (t = 2.32, df = 38, P <.05) and post-cold pressor pain ratings (t = 2.6, df = 37, P <.05) were found. Women had briefer tolerance times and higher post-cold pressor ratings than men. When given gender-specific tolerance expectations, men and women did not differ in their pain tolerance, pain threshold, or pain ratings. This is the first empirical study to show that manipulation of expectations alters sex differences in laboratory pain.

[Do online ratings reflect structural differences in healthcare? The example of German physician-rating websites].

PubMed

Meszmer, Nina; Jaegers, Lena; Schöffski, Oliver; Emmert, Martin

2018-04-01

Previous surveys have shown that patient satisfaction varies with the regional supply of physicians. Online ratings on physician-rating websites represent a relatively new instrument to display patient satisfaction results. The aim of this study was (1) to assess the current state of online ratings for two medical disciplines (dermatologists and ear, nose and throat (ENT) specialists), and (2) to analyze online derived patient satisfaction results according to the physician density in Germany. We collected online ratings for 420 dermatologists and 450 ear, nose, and throat (ENT) specialists on twelve German physician-rating websites. We analyzed the online ratings according to the physician density (low, medium, high physician density). For this purpose, we collected secondary data from both physician-rating websites and the regional associations of statutory health insurance physicians. Data analysis was performed using Median tests and Chi-square tests. In total, 10,239 online ratings for dermatologists and 8,168 online ratings for ENT specialists were analyzed. Almost all dermatologists (99.3 %) and ENT specialists (98.9 %) were listed on one of the physician-rating websites. A total of 93.5 % of all listed dermatologists and 96.9 % of ENT-specialists were rated on at least one of the physician-rating websites. Significant differences were found in the distribution (i.e., percentage of listed or rated physicians) of the ratings according to the regional physician density on only one physician-rating website (p<0.001). Furthermore, online ratings were shown to be better in regions with a higher physician density on two physician-rating website. On jameda.de, for example, dermatologist ratings were better in regions with a higher physician density compared to regions with a lower number of physicians (average rating: 2.16 vs. 2.67; p<0.001). Online ratings of dermatologists and ENT specialists hardly differ in terms of regional physician density. Physician-rating websites thus do not appear to be appropriate to mirror differences in the health service delivery structure. Our findings thus do not confirm the results from previously published studies. Copyright © 2018. Published by Elsevier GmbH.

Dearth by a Thousand Cuts? Accounting for Gender Differences in Top-Ranked Publication Rates in Social Psychology.

PubMed

Cikara, Mina; Rudman, Laurie; Fiske, Susan

2012-01-01

Publication in the Journal of Personality and Social Psychology , a flagship indicator of scientific prestige, shows dramatic gender disparities. A bibliometric analysis included yoked-control authors matched for Ph.D. prestige and cohort. Though women publish less, at slower annual rates, they are more cited in handbooks and textbooks per JPSP -article-published. No gender differences emerged on variables reflecting differential qualifications. Many factors explain gender discrepancy in productivity. Among top publishers, per-year rate and first authorship especially differ by gender; rate uniquely predicts top-male productivity, whereas career-length uniquely predicts top-female productivity. Among men, across top-publishers and controls, productivity correlates uniquely with editorial negotiating and being married. For women, no personal variables predict productivity. A separate inquiry shows tiny gender differences in acceptance rates per JPSP article submitted; discrimination would be a small-but-plausible contributor, absent independent indicators of manuscript quality. Recent productivity rates mirror earlier gender disparities, suggesting gender gaps will continue.

Quantifying the Search Behaviour of Different Demographics Using Google Correlate

PubMed Central

Letchford, Adrian; Preis, Tobias; Moat, Helen Susannah

2016-01-01

Vast records of our everyday interests and concerns are being generated by our frequent interactions with the Internet. Here, we investigate how the searches of Google users vary across U.S. states with different birth rates and infant mortality rates. We find that users in states with higher birth rates search for more information about pregnancy, while those in states with lower birth rates search for more information about cats. Similarly, we find that users in states with higher infant mortality rates search for more information about credit, loans and diseases. Our results provide evidence that Internet search data could offer new insight into the concerns of different demographics. PMID:26910464

[Comparison of Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia and peptic ulcer diseases according to proton pump inhibitors].

PubMed

Hong, Eun Jung; Park, Dong Il; Oh, Suk Joong; Song, Min Jun; Choi, Woo Hyuk; Hong, Cheul Ho; Park, Jung Ho; Kim, Hong Joo; Cho, Yong Kyun; Shon, Chong Il; Jeon, Woo Kyu; Kim, Byung Ik

2008-08-01

Conflicting results have been reported whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori (H. pylori) eradication treatment compared with patients with peptic ulcer diseases (PUD). The aim of this study was to evaluate any difference in H. pylori eradication rates between patients with NUD and PUD according to each proton pump inhibitor (PPI). From September, 2004 to April, 2007, we retrospectively reviewed 2,297 patients with NUD (1,050 patients) or PUD (1,247 patients) infected with H. pylori. All patients received a standard 1 week triple therapy comprising of one of the five PPIs (pantoprazole, esomeprazole, omeprazole, lansoprazole, rabeprazole), clarithromycin and amoxicillin. The follow-up H. pylori test was performed 4 weeks after the completion of therapy. There was no significant difference in the eradication rates between the two groups. In comparison of eradication rates according to PPI, omeprazole- based triple therapy group showed higher eradication rate than other groups in patients with NUD, but not in patients with PUD. This study failed to show any difference in H. pylori eradication rate between patients with NUD and PUD. There is no convincing evidence that the eradication rate may be affected by different PPI.

Variation of thermal parameters in two different color morphs of a diurnal poison toad, Melanophryniscus rubriventris (Anura: Bufonidae).

PubMed

Sanabria, Eduardo A; Vaira, Marcos; Quiroga, Lorena B; Akmentins, Mauricio S; Pereyra, Laura C

2014-04-01

We study the variation in thermal parameters in two contrasting populations Yungas Redbelly Toads (Melanophryniscus rubriventris) with different discrete color phenotypes comparing field body temperatures, critical thermal maximum and heating rates. We found significant differences in field body temperatures of the different morphs. Temperatures were higher in toads with a high extent of dorsal melanization. No variation was registered in operative temperatures between the study locations at the moment of capture and processing. Critical thermal maximum of toads was positively related with the extent of dorsal melanization. Furthermore, we founded significant differences in heating rates between morphs, where individuals with a high extent of dorsal melanization showed greater heating rates than toads with lower dorsal melanization. The color pattern-thermal parameter relationship observed may influence the activity patterns and body size of individuals. Body temperature is a modulator of physiological and behavioral functions in amphibians, influencing daily and seasonal activity, locomotor performance, digestion rate and growth rate. It is possible that some growth constraints may arise due to the relationship of color pattern-metabolism allowing different morphs to attain similar sizes at different locations instead of body-size clines. Copyright © 2014. Published by Elsevier Ltd.

Rate of introduction of a low pathogenic avian influenza virus infection in different poultry production sectors in the Netherlands

PubMed Central

Gonzales, Jose L.; Stegeman, Jan A.; Koch, Guus; de Wit, Sjaak J.; Elbers, Armin R. W.

2012-01-01

Please cite this paper as: Gonzales et al. (2012) Rate of introduction of a low pathogenic avian influenza virus infection in different poultry production sectors in the Netherlands. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2012.00348.x. Background  Targeted risk‐based surveillance of poultry types (PT) with different risks of introduction of low pathogenic avian influenza virus (LPAIv) infection may improve the sensitivity of surveillance. Objective  To quantify the rate of introduction of LPAIv infections in different PT. Methods  Data from the Dutch LPAIv surveillance programme (2007–2010) were analysed using a generalised linear mixed and spatial model. Results  Outdoor‐layer, turkey, duck‐breeder and meat‐duck, farms had a 11, 8, 24 and 13 times higher rate of introduction of LPAIv than indoor‐layer farms, respectively. Conclusion  Differences in the rate of introduction of LPAIv could be used to (re)design a targeted risk‐based surveillance programme. PMID:22376126

How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: a 50-year journey.

PubMed

Menotti, A; Puddu, P E

2015-03-01

The Seven Countries Study of Cardiovascular Diseases was started at the end of the 1950s and it continues to be run after >50 years. It enrolled, at entry, 16 population cohorts in eight nations of seven countries for a total of 12,763 middle-aged men. It was the prototype of epidemiological studies seeking cultural contrasts and the first to compare cardiovascular disease (CVD) rates related to diet differences. The study has shown that populations suffer widely different incidence and mortality rates from coronary heart disease (CHD) as well as from other CVDs and overall mortality. Higher rates were found in North America and northern Europe, and lower rates in southern Europe - Mediterranean countries - and Japan. These differences in CHD rates were strongly associated with different levels of saturated fat consumption and average serum cholesterol levels, with lowest rates in Greece and Japan where the total fat intake was very different. The cohorts were also different in dietary patterns defined by the ratio of calories derived from plant foods and fish on the one hand and calories derived from animal foods and sugar on the other. These findings pointed to the so-called Mediterranean diet, which is characterized by large values of that plant/animal ratio, a pattern associated with lower incidence and mortality from CHD and also with the lowest death rates and the greatest survival rates. More recent studies have refined these concepts and documented on a larger scale the virtues of these eating habits. Copyright © 2014 Elsevier B.V. All rights reserved.

Regional Difference of Causative Pollen in Children with Allergic Rhinitis.

PubMed

Sung, Myongsoon; Kim, Sung Won; Kim, Jeong Hee; Lim, Dae Hyun

2017-06-01

The aim of this study was to investigate role of common pollen in Korean school-aged children with allergic rhinitis (AR) in 5 provinces (Incheon Metropolitan City-Gyeonggi Province, Chungcheongbuk-do, Gwangju Metropolitan City, Busan Metropolitan City, and Jeju Special Self-Governing Province), using a questionnaire and skin prick test, and to assess the differences among the residential regions. Among the enrolled 14,678 total children, 1,641 (22.0%) had AR. The sensitization rate to pollen (38.7%) was the second highest among examined allergens and significant differences were in the sensitization rates to trees, weeds, and grasses among the 5 provinces (P < 0.05). The sensitization to trees (25.2%) was the highest common among the pollen types and significant differences also were observed in the sensitization rates to alder, birch, Japanese cedar, oak, and elm among the 5 provinces. The sensitization rate to weeds (19.9%) was the second highest and significant differences were observed in the sensitization rate to Japanese hop, mugwort, and ragweed among the 5 provinces. The sensitization rate to house dust mite was 86.8%, the highest among examined allergens and that to Dermatophagoides farinae exhibited regional differences (P = 0.003) but not to D. farinae (P = 0.584). The sensitization rate to mold (13.5%) was the highest in Jeju and lowest in Busan, and a statistically significant difference was detected among the 5 provinces. These results support that examined pollen allergens are strongly associated with residential region due to regional causative pollen differences among children with AR within Korea to investigate the main pollen allergens. © 2017 The Korean Academy of Medical Sciences.

Individual response differences in spider phobia: comparing phobic and non-phobic women of different reactivity levels.

PubMed

Knopf, Kerstin; Pössel, Patrick

2009-01-01

In contrast to previous stress research, studies concerning phobic disorders have never systematically investigated individual response differences between phobic participants integrating numerous different response measures. The aim of this article is to clarify the existence of significant individual response differences in psychophysiological responses (e.g., heart rate, skin conductance responses (SCR), corrugator, cortisol), subjective ratings (e.g., valence, arousal), and avoidance behavior in 46 spider phobic and 44 non-phobic women when exposed to 20 phobic and 20 neutral pictures. Previous studies that did not attend to individual response differences showed that, during phobic stimulation, phobic individuals have increased psychophysiological responses (heart rate, SCR, and corrugator responses), more negative valence rating, and more subjective arousal than non-phobic individuals. These results were confirmed by our data. With regard to individual response uniqueness, 1/3-2/3 of spider-phobic women with low responsiveness in heart rate, cortisol, and avoidance behavior were indistinguishable from non-phobic women during phobic stimulation. With SCR, corrugator EMG, and subjective ratings, no individual response uniqueness was found. Based on the findings, exposure therapy might be improved by tailoring interventions to individuals with a therapeutic focus on those psychophysiological measures that show the highest individual responsivity.

Occupational fatality risks in the United States and the United Kingdom.

PubMed

Mendeloff, John; Staetsky, Laura

2014-01-01

There are very few careful studies of differences in occupational fatality rates across countries, much less studies that try to account for those differences. We compare the rate of work injury fatalities (excluding deaths due to highway motor vehicle crashes and those due to violence) identified by the US Census of Fatal Occupational Injuries in recent years with the number reported to the Health and Safety Executive in the United Kingdom (UK) and by other European Union (EU) members through Eurostat. In 2010, the fatality rate in the UK was about 1/3 the rate in the US. In construction the rate was about ¼ the US rate, a difference that had grown substantially since the 1990s. Several other EU members had rates almost as low as the UK rate. Across EU countries, lower rates were associated with high-level management attention to safety issues and to in-house preparation of "risk assessments." Although work fatality rates have declined in the US, fatality rates are much lower and have declined faster in recent years in the UK. Efforts to find out the reasons for the much better UK outcomes could be productive. © 2013 Wiley Periodicals, Inc.

A study comparing three different laser-assisted hatching techniques.

PubMed

Ma, B; Wang, Y; Zhang, H; Zhang, X

2014-01-01

Laser-assisted hatching (LAH) is recognized as a useful technology to improve clinical pregnancy rates and implantation rates. This study reports the differences between a new LAH method and two conventional LAH techniques. The authors studied 151 patients with repeated implantation failure, who were divided into three groups. In group 1, the zona pellucida (ZP) was opened using LAH (n = 52). In group 2, laser-assisted thinning was performed to dissolve the outer layer of the ZP (n = 49). In group 3, laser-assisted thinning was performed to dissolve the inner layer of the ZP (n = 50). The clinical pregnancy rates and implantation rates among the groups were compared. The results demonstrate that there are significant differences in the clinical pregnancy rates and implantation rates between group 3 and the other two groups. Performing laser-assisted thinning to dissolve the inner layer of the ZP markedly increases the pregnancy rates and implantation rates of patients with repeated implantation failure.

Determination of excimer laser ablation rate of the human cornea using in vivo Scheimpflug videography.

PubMed

Huebscher, H J; Genth, U; Seiler, T

1996-01-01

To determine in vivo the amount of human corneal tissue removed by each excimer laser pulse, the so-called ablation rate, during photorefractive keratectomy (PRK). There is confusion in the literature because the experimentally determined ablation rate of 0.4 to 0.5 microns per pulse differs from the nominal ablation rate of 0.23 to 0.3 microns per pulse, which is the value used in clinical procedures. Eleven eyes of 11 patients were treated with PRK for correction of myopia. The corneal curvature was determined by Scheimpflug videography before and immediately after surgery. Starting from this curvature change, the authors calculated the real ablation rate. The real ablation rate is coincident with the nominal ablation rate and differs significantly from the ablation rate derived from deep keratectomy experiments. The outer layers of the cornea show significantly different ablation behavior than the deeper stroma. This information has clinical relevance for the predictability of intrastromal excimer laser procedures.

Rate-compatible protograph LDPC code families with linear minimum distance

NASA Technical Reports Server (NTRS)

Divsalar, Dariush (Inventor); Dolinar, Jr., Samuel J (Inventor); Jones, Christopher R. (Inventor)

2012-01-01

Digital communication coding methods are shown, which generate certain types of low-density parity-check (LDPC) codes built from protographs. A first method creates protographs having the linear minimum distance property and comprising at least one variable node with degree less than 3. A second method creates families of protographs of different rates, all having the linear minimum distance property, and structurally identical for all rates except for a rate-dependent designation of certain variable nodes as transmitted or non-transmitted. A third method creates families of protographs of different rates, all having the linear minimum distance property, and structurally identical for all rates except for a rate-dependent designation of the status of certain variable nodes as non-transmitted or set to zero. LDPC codes built from the protographs created by these methods can simultaneously have low error floors and low iterative decoding thresholds, and families of such codes of different rates can be decoded efficiently using a common decoding architecture.

Cystic fibrosis transmembrane conductance regulator protein expression rate in healthy spermatozoa is not correlated with ovum fertilisation rate.

PubMed

Li, H-G; Xu, C-M; Chen, W-Y; Shi, Q-X; Ni, Y

2012-05-01

Our previous studies have shown that the cystic fibrosis transmembrane conductance regulator (CFTR) was important for capacitation and fertilisation in mouse, guinea pig and human spermatozoa. However, it is unclear whether CFTR is correlated with ovum fertilisation rate. The present study was to test the possible relationship between spermatozoa CFTR protein expression rate in healthy men and ovum fertilisation rate during in vitro fertilisation. Ninety-four couples for female factor infertility for IVF-ET treatments were retrospectively studied. All the patients were divided into three groups based on the fertilisation rate of ovum in vitro. It was performed to explore whether there were differences in sperm CFTR protein expression rate among the three groups and the relevance between CFTR protein expression rate and ovum fertilisation rate. Our study showed that there was no significant differences in sperm CFTR protein expression rate among the three groups (F = 0.614, P = 0.544), and the relevance between spermatozoa CFTR protein expression rate and ovum fertilisation rate was not significantly different (r = 0.013, P = 0.904). These results further suggest that CFTR protein expression rate in healthy men spermatozoa was not associated with ovum fertilisation rate and thus we cannot predict ovum fertilisation results by sperm CFTR protein expression rate. © 2011 Blackwell Verlag GmbH.

Is gender a factor in perceived prison officer competence? Male prisoners' perceptions in an English dispersal prison.

PubMed

Boyd, Elizabeth; Grant, Tim

2005-01-01

The introduction of women officers into HM Prison Service raised questions regarding women's ability to perform what had traditionally been a male role. Existing research is inconclusive as to whether female prison officers are as competent as male prison officers, and whether there are gender differences in job performance. This study examined prisoners' perceptions of male and female prison officers' performance. The hypotheses were that overall competence and professionalism ratings would not differ for men and women officers, but that there would be differences in how men and women were perceived to perform their roles. Women were expected to be rated as more communicative, more empathic and less disciplining. The Prison Officer Competency Rating Scale (PORS) was designed for this study. Ratings on the PORS for male and female officers were given by 57 adult male prisoners. There was no significant difference in prisoners' ratings of overall competence of men and women officers. Of the PORS subscales, there were no gender differences in Discipline and Control, Communication or Empathy, but there was a significant difference in Professionalism, where prisoners rated women as more professional. The failure to find any differences between men and women in overall job competence, or on communication, empathy and discipline, as perceived by prisoners, suggests that men and women may be performing their jobs similarly in many respects. Women were rated as more professional, and items contributing to this scale related to respecting privacy and keeping calm in difficult situations, where there may be inherent gender biases.

Comparing Cultural Differences in Two Quality Measures in Chinese Kindergartens: The Early Childhood Environment Rating Scale-Revised and the Kindergarten Quality Rating System

ERIC Educational Resources Information Center

Hu, Bi Ying

2015-01-01

This study examined the degrees of congruence between two early childhood evaluation systems on various quality concepts: the Early Childhood Environment Rating Scale-Revised (ECERS-R) and Zhejiang's Kindergarten Quality Rating System (KQRS). Analysis of variance and post hoc least significant difference tests were employed to show the extent to…

Lung Cancer Resection at Hospitals With High vs Low Mortality Rates.

PubMed

Grenda, Tyler R; Revels, Sha'Shonda L; Yin, Huiying; Birkmeyer, John D; Wong, Sandra L

2015-11-01

Wide variations in mortality rates exist across hospitals following lung cancer resection; however, the factors underlying these differences remain unclear. To evaluate perioperative outcomes in patients who underwent lung cancer resection at hospitals with very high and very low mortality rates (high-mortality hospitals [HMHs] and low-mortality hospitals [LMHs]) to better understand the factors related to differences in mortality rates after lung cancer resection. In this retrospective cohort study, 1279 hospitals that were accredited by the Commission on Cancer were ranked on a composite measure of risk-adjusted mortality following major cancer resections performed from January 1, 2005, through December 31, 2006. We collected data from January 1, 2006, through December 31, 2007, on 645 lung resections in 18 LMHs and 25 HMHs. After adjusting for patient characteristics, we used hierarchical logistic regression to examine differences in the incidence of complications and "failure-to-rescue" rates (defined as death following a complication). Rates of adherence to processes of care, incidence of complications, and failure to rescue following complications. Among 645 patients who received lung resections (441 in LMHs and 204 in HMHs), the overall unadjusted mortality rates were 1.6% (n = 7) vs 10.8% (n = 22; P < .001) for LMHs and HMHs, respectively. Following risk adjustment, the difference in mortality rates was attenuated (1.8% vs 8.1%; P < .001) but remained significant. Overall, complication rates were higher in HMHs (23.3% vs 15.6%; adjusted odds ratio [aOR], 1.79; 95% CI, 0.99-3.21), but this difference was not significant. The likelihood of any surgical (aOR, 0.73; 95% CI, 0.26-2.00) or cardiopulmonary (aOR, 1.23; 95% CI, 0.70-2.16) complications was similar between LMHs and HMHs. However, failure-to-rescue rates were significantly higher in HMHs (25.9% vs 8.7%; aOR, 6.55; 95% CI, 1.44-29.88). Failure-to-rescue rates are higher at HMHs, which may explain the large differences between hospitals in mortality rates following lung cancer resection. This finding emphasizes the need for better understanding of the factors related to complications and their subsequent management.

Variations in magma supply rate at Kilauea Volcano, Hawaii

USGS Publications Warehouse

Dvorak, John J.; Dzurisin, Daniel

1993-01-01

When an eruption of Kilauea lasts more than 4 months, so that a well-defined conduit has time to develop, magma moves freely through the volcano from a deep source to the eruptive site at a constant rate of 0.09 km3/yr. At other times, the magma supply rate to Kilauea, estimated from geodetic measurements of surface displacements, may be different. For example, after a large withdrawal of magma from the summit reservoir, such as during a rift zone eruption, the magma supply rate is high initially but then lessens and exponentially decays as the reservoir refills. Different episodes of refilling may have different average rates of magma supply. During four year-long episodes in the 1960s, the annual rate of refilling varied from 0.02 to 0.18 km3/yr, bracketing the sustained eruptive rate of 0.09 km3/yr. For decade-long or longer periods, our estimate of magma supply rate is based on long-term changes in eruptive rate. We use eruptive rate because after a few dozen eruptions the volume of magma that passes through the summit reservoir is much larger than the net change of volume of magma stored within Kilauea. The low eruptive rate of 0.009 km3/yr between 1840 and 1950, compared to an average eruptive rate of 0.05 km3/yr since 1950, suggests that the magma supply rate was lower between 1840 and 1950 than it has been since 1950. An obvious difference in activity before and since 1950 was the frequency of rift zone eruptions: eight rift zone eruptions occurred between 1840 and 1950, but more than 20 rift zone eruptions have occurred since 1950. The frequency of rift zone eruptions influences magma supply rate by suddenly lowering pressure of the summit magma reservoir, which feeds magma to rift zone eruptions. A temporary drop of reservoir pressure means a larger-than-normal pressure difference between the reservoir and a deeper source, so magma is forced to move upward into Kilauea at a faster rate.

[Human papillomavirus infection and cervical intraepithelial neoplasia morbidity of women from different occupations in Shenzhen city, China].

PubMed

Tang, Hui-ru; Zhou, Yan-qiu; Wu, Lan-na; Liu, Zhi-hong; Zhang, Li-jie; Wu, Rui-fang

2007-10-01

To investigate the human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) morbidity of women from different occupations in Shenzhen city. 2045 women of five kinds of occupation in Shenzhen city, including 130 teachers, 385 workers, 316 service women, 199 poverish women, 420 doctors or nurses and 595 general residents were included. We screened these women by methods of detecting high risk HPV of hc2 combing with LCT. Women with screening positive results were diagnosed CIN by colposcopic biopsy. (1) High risk factors on HPV infection rate in different occupations were different with the highest in service occupation (19.3%) while the lowest appeared in medical workers (11.9%). (2) In those 2045 women, we found 199 cervical lesions including pathological HPV infection, CIN1, 2, 3 and cervical cancers, with morbidity rates as 4.11%, 3.28%, 1.67%, 0.54% and 0.15% respectively. Along with the progress of the cervical lesions, the morbidity decreased. (3) The morbidity rates of CIN in different occupations were different, with the highest of HSIL in service occupation and the lowest in teachers. Women of different occupations in Shenzhen city had different high risk HPV infection rates and CIN morbidity. The HPV infection rate and HSIL morbidity were highest among women having service related jobs.

Optimal Spray Application Rates for Ornamental Nursery Liner Production

USDA-ARS?s Scientific Manuscript database

Spray deposition and coverage at different application rates for nursery liners of different sizes were investigated to determine the optimal spray application rates. Experiments were conducted on two and three-year old red maple liners. A traditional hydraulic sprayer with vertical booms was used t...

29 CFR 548.303 - Average earnings for each type of work.

Code of Federal Regulations, 2010 CFR

2010-07-01

... performs different types of work, each involving a different rate of pay such as different piece-rate, job... 40 hours works six 8-hour days in a workweek under an agreement or understanding reached pursuant to...

Comparison between Euro NCAP test results and real-world crash data.

PubMed

Kullgren, Anders; Lie, Anders; Tingvall, Claes

2010-12-01

The objective of this study was 2-fold: first, to compare Euro NCAP safety ratings of cars with those published by the Folksam real-world injury ratings; and second, to compare injury risk measures between Euro NCAP 2 and 5 Star cars with real-world injury and disability outcomes using police and insurance injury data. Car models were grouped according to the Euro NCAP star rating scores. Folksam risk of injury ratings come from statistical analysis of real-world crashes using police and insurance databases. The paired comparison method using 2-car crashes was used to control for crash speed and the mass differences between cars of different weights were normalized. For all comparisons, 5-star rated Euro NCAP cars were found to have a lower risk of injury compared to 2-star rated cars (5-star cars were 10% ± 2.5% lower risk than 2-star cars). For fatal and serious injuries, the difference was 23 ± 8 percent, and for fatal injuries alone the difference was 68 ± 32 percent. By comparison, the Folksam 5-star rated cars had a relative risk of 0.020 ± 0.0024, whereas 2-star rated car risk was 0.028 ± 0.0016, corresponding to a 27 percent difference in risk between 5- and 2-star cars. Good correlation was found between Euro NCAP test results and real-world injury outcomes. The largest difference in injury risk between 2- and 5-star rated cars in Euro NCAP was found for risk of fatality, confirming that car manufacturers have focused their safety performance on serious crash outcomes. In addition, Euro NCAP crash tests were shown to be highly correlated with serious crash performance, confirming their relevance for evaluating real-world crash performance. Good concordance was found between Euro NCAP and Folksam real-world crash and injury ratings.

[The effects of different interventions on 12-year-old children's permanent teeth caries and filling rate in Shanghai Jiading district].

PubMed

Zhang, Shu-yu; Dong, Hua; Yu, Ming

2015-06-01

To evaluate the effects of different interventions on 12-year-old children's permanent teeth caries and filling rates in Shanghai Jiading District. Six hundred and ninety-one 12-year-old children from 3 middle schools were randomly divided into 3 groups. The filling intervention group received filling of the permanent teeth free of charge for 3 years; The health education group received oral health education for 3 years; The control group only accepted oral examination for 3 years. The data was analyzed with SPSS 20.0 software package for X2 test. On the baseline, the permanent teeth caries rates of 3 groups were 32.10%, 35.56% and 36.84%, and the filling rates were 17.07%, 16.24% and 17.04%, respectively. After 1 year, permanent teeth caries rates of 3 groups were 35.92%, 42.26% and 44.50%, respectively. There was no significant difference among the 3 groups (P>0.05). The filling rates were 93.28%, 61.41%, and 16.67%, respectively. There was significant difference among the 3 groups (P<0.05). After 3 years, permanent teeth caries rates of 3 groups were 37.04%, 48.12% and 58.85%, and the filling rates were 93.66%, 61.51% and 17.28%, respectively. There were significant differences among the 3 groups (P<0.05). Filling intervention and health education can significantly reduce the permanent teeth caries prevalence rate and improve permanent teeth caries filling rate of 12-year-old children. Furthermore, the effects of filling intervention were more significant than the health education intervention. Supported by Medical Research Project of Science and Technology Committee of Shanghai Jiading District (2014-KW-04).

Quantifying the utilization of medical devices necessary to detect postmarket safety differences: A case study of implantable cardioverter defibrillators.

PubMed

Bates, Jonathan; Parzynski, Craig S; Dhruva, Sanket S; Coppi, Andreas; Kuntz, Richard; Li, Shu-Xia; Marinac-Dabic, Danica; Masoudi, Frederick A; Shaw, Richard E; Warner, Frederick; Krumholz, Harlan M; Ross, Joseph S

2018-06-12

To estimate medical device utilization needed to detect safety differences among implantable cardioverter defibrillators (ICDs) generator models and compare these estimates to utilization in practice. We conducted repeated sample size estimates to calculate the medical device utilization needed, systematically varying device-specific safety event rate ratios and significance levels while maintaining 80% power, testing 3 average adverse event rates (3.9, 6.1, and 12.6 events per 100 person-years) estimated from the American College of Cardiology's 2006 to 2010 National Cardiovascular Data Registry of ICDs. We then compared with actual medical device utilization. At significance level 0.05 and 80% power, 34% or fewer ICD models accrued sufficient utilization in practice to detect safety differences for rate ratios <1.15 and an average event rate of 12.6 events per 100 person-years. For average event rates of 3.9 and 12.6 events per 100 person-years, 30% and 50% of ICD models, respectively, accrued sufficient utilization for a rate ratio of 1.25, whereas 52% and 67% for a rate ratio of 1.50. Because actual ICD utilization was not uniformly distributed across ICD models, the proportion of individuals receiving any ICD that accrued sufficient utilization in practice was 0% to 21%, 32% to 70%, and 67% to 84% for rate ratios of 1.05, 1.15, and 1.25, respectively, for the range of 3 average adverse event rates. Small safety differences among ICD generator models are unlikely to be detected through routine surveillance given current ICD utilization in practice, but large safety differences can be detected for most patients at anticipated average adverse event rates. Copyright © 2018 John Wiley & Sons, Ltd.

[Evaluation of endometriosis fertility index in follow-up treatment of endometriosis combined with infertility patients after laparoscopic surgery].

PubMed

Qian, R Y; Wu, X; Sheng, J; Zheng, P; Zhou, Q; Duan, A H; Zhang, J P; Zhang, Y L; Lu, D

2017-04-25

Objective: To explore the application of endometriosis fertility index (EFI) in guidance after laparoscopic surgery of endometriosis patients combined with infertility and to explore methods to improve pregnancy rate in different EFI groups. Methods: A prospective research was done in endometriosis patients combined with infertility in Beijing Obstetrics and Gynecology Hospital from January 2010 to June 2011, after laparoscopic surgery, these 146 patients were divided into 3 groups by EFI score. Using different pregnancy guidance, these patients had 5 years follow-up. Results: (1) The 5 years overall pregnancy rate was 89.0% (130/146). The pregnancy rate was 95.7% (45/47) in EFI≥9 group, 92.8% (77/83) in EFI 5-8 group and 8/16 in EFI≤4 group, three groups were all reach satisfactory pregnancy rate; the rate of the first two groups had no statistically significance ( P= 0.498), but had significant difference with the last group ( P< 0.01). (2) In EFI≥5 patients, pregnancy rate was the highest in 6 months after operation; in EFI≥9 group, the pregnancy rate was 66.7% (30/45), and EFI 5-8 group was 50.6% (39/77). (3) EFI≥9 group had the highest natural pregnancy rate [83.6% (46/55)], natural pregnancy rate was significant statistical different in different EFI groups ( P= 0.001). Conclusions: EFI score is a useful evaluation in predicting and guiding pregnancy in endometriosis patients combined with infertility after laparoscopic surgery. EFI score guidance, strict post-operation management and positive pregnancy scheme could significantly improve the pregnancy rate of endometriosis patients with infertility.

Foreign nationals who receive science or engineering Ph.D.`s from US universities: Stay rates and characteristics of stayers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finn, M.G.; Pennington, L.A.; Anderson, K.H.

1995-04-01

This report studies the behavior of foreign nationals who received Ph.D. degrees in science or engineering from US universities during the period 1984--1990. It addresses two distinct questions: What proportion of foreign students stay to work in the United States after graduation; and do foreign students who leave the United States differ from those who stay? Descriptive statistics are provided to answer the first question. These estimates of stay rates have small margins of error because they were produced from the tax payment records of the Social Security Administration. The estimates of stay rates in also provide a partial answermore » to the second question as well as we are able to provide stay rates for different degree fields and different countries of citizenship, thereby identifying country-specific and field-specific differences in stay rates.« less

Does age matter? The influence of age on response rates in a mixed-mode survey

USGS Publications Warehouse

Gigliotti, Larry M.; Dietsch, Alia

2014-01-01

The appeal of cost savings and faster results has fish and wildlife management agencies considering the use of Internet surveys instead of traditional mail surveys to collect information from their constituents. Internet surveys, however, may suffer from differential age-related response rates, potentially producing biased results if certain age groups respond to Internet surveys differently than they do to mail surveys. We examined this concern using data from a mixed-mode angler survey conducted in South Dakota following the 2011 fishing season. Results indicated that young anglers (16–18) had the lowest return rates and senior anglers (65+) had the highest, regardless of survey mode. Despite this consistency in response rates, we note two concerns: (a) lower Internet response rates and (b) different age groups represented by the Internet and mail survey samples differed dramatically. Findings indicate that constituent groups may be represented differently with the use of various survey modes.

Clock-like mutational processes in human somatic cells

DOE PAGES

Alexandrov, Ludmil B.; Jones, Philip H.; Wedge, David C.; ...

2015-11-09

During the course of a lifetime, somatic cells acquire mutations. Different mutational processes may contribute to the mutations accumulated in a cell, with each imprinting a mutational signature on the cell's genome. Some processes generate mutations throughout life at a constant rate in all individuals, and the number of mutations in a cell attributable to these processes will be proportional to the chronological age of the person. Using mutations from 10,250 cancer genomes across 36 cancer types, we investigated clock-like mutational processes that have been operating in normal human cells. Two mutational signatures show clock-like properties. Both exhibit different mutationmore » rates in different tissues. However, their mutation rates are not correlated, indicating that the underlying processes are subject to different biological influences. For one signature, the rate of cell division may influence its mutation rate. This paper provides the first survey of clock-like mutational processes operating in human somatic cells.« less

Clock-like mutational processes in human somatic cells

PubMed Central

Alexandrov, Ludmil B.; Jones, Philip H.; Wedge, David C.; Sale, Julian E.; Campbell, Peter J.; Nik-Zainal, Serena; Stratton, Michael R.

2016-01-01

During the course of a lifetime somatic cells acquire mutations. Different mutational processes may contribute to the mutations accumulated in a cell, with each imprinting a mutational signature on the cell’s genome. Some processes generate mutations throughout life at a constant rate in all individuals and the number of mutations in a cell attributable to these processes will be proportional to the chronological age of the person. Using mutations from 10,250 cancer genomes across 36 cancer types, we investigated clock-like mutational processes that have been operating in normal human cells. Two mutational signatures show clock-like properties. Both exhibit different mutation rates in different tissues. However, their mutation rates are not correlated indicating that the underlying processes are subject to different biological influences. For one signature, the rate of cell division may influence its mutation rate. This study provides the first survey of clock-like mutational processes operative in human somatic cells. PMID:26551669

International and cross-cultural dimensions of treatment decisions for neonates.

PubMed

Lantos, John D

2015-10-01

Neonatal mortality rates vary widely among countries. According to data from the World Health Organization, neonatal mortality in low- and low-middle-income countries is ∼30 per 1000 babies. In upper middle-income countries, that number was just 10 per 1000. In the highest-income countries, it was <5 per 1000. These data may not be accurate. Many countries do not report the tiniest babies as live births. Thus, their reported infant mortality rates are much lower than their actual infant mortality rates. Another big difference between countries is in the rate at which congenital anomalies are diagnosed prenatally and the rate at which pregnancies are terminated by induced abortion. International comparisons therefore reflect differences in the way countries define live birth, the comprehensiveness of the reporting of live births even by their own definitions, differences in the prevalence of congenital anomalies, the rate at which those congenital anomalies are diagnosed prenatally, and the percentage of pregnancies with congenital anomalies that end in abortion. This article reviews these differences and discusses the implications for the ways in which we think about international differences in decisions about life-sustaining treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Self-rated health and mortality in different occupational classes and income groups in Nord-Trøndelag County, Norway.

PubMed

Holseter, Christoffer; Dalen, Joakim Døving; Krokstad, Steinar; Eikemo, Terje Andreas

2015-03-10

People with a lower socioeconomic position have a higher the prevalence of most self-rated health problems. In this article we ask whether this may be attributed to self-rated health not reflecting actual health, understood as mortality, in different socioeconomic groups. For the study we used data from the Nord-Trøndelag Health Study 1984-86 (HUNT1), in which the county's entire adult population aged 20 years and above were invited to participate. The association between self-rated health and mortality in different occupational classes and income groups was analysed. The analysis corrected for age, chronic disease, functional impairment and lifestyle factors. The association between self-rated health and mortality was of the same order of magnitude for the occupational classes and income groups, but persons without work/income and with poor self-rated health stood out. Compared with persons in the highest socioeconomic class, unemployed men had a hazard ratio for death that was three times higher in the follow-up period. For women with no income, the ratio was twice as high. INTERPRETATION Self-rated health and mortality largely conform to the different socioeconomic strata. This supports the perception that socioeconomic differences in health are a reality and represent a significant challenge nationally. Our results also increase the credibility of findings from other studies that use self-reported health in surveys to measure differences and identify the mechanisms that create them.

Comparison of the Cumulative Incidence Rates of Coal Workers’ Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China

PubMed Central

Cui, Kai; Shen, Fuhai; Han, Bing; Yuan, Juxiang; Suo, Xia; Qin, Tianbang; Liu, Hongbo; Chen, Jie

2015-01-01

The purpose of this study was to identify differences in the incidence characteristics of coal workers’ pneumoconiosis (CWP) based on data from four large state-owned colliery groups of China, by comparing the cumulative incidence rates of CWP. We investigated 87,904 coal workers from the Datong, Kailuan, Fuxin, and Tiefa Colliery Groups, who were exposed to dust for at least 1 year. The cumulative incidence rate of CWP was calculated with the life-table method and stratified analysis among coal workers with different occupational categories during different years of first dust exposure. Our results showed the cumulative incidence rate of Datong was higher than that of any other colliery group among workers with different occupational categories during different years of first dust exposure. For Datong workers who started their dust exposure in the 1970s, the cumulative incidence rates of CWP among tunneling, mining, combining, and helping workers were 34.77%, 10.20%, 34.59%, and 4.91% during the observed time of 34 years, respectively. For those in the 1980s, the cumulative incidence rates were 32.29%, 13.51%, 2.98%, and 0.47%, respectively. The cumulative incidence rates of Fuxin and Tiefa were the lowest. In conclusion, the Datong colliery has the highest cumulative incidence rate of CWP among the four studied collieries, followed by Kailuan. The cumulative incidence rates of Fuxin and Tiefa were the lowest. Additional dust-proofing measures for decreasing dust concentrations are still necessary. PMID:26133134

Early-Stage Estimated Value of Blend Sign on the Prognosis of Patients with Intracerebral Hemorrhage

PubMed Central

Zhou, Ningquan; Wang, Chao

2018-01-01

Background and Purpose This study aimed to explore the relationship between blend sign and prognosis of patients with intracerebral hemorrhage (ICH). Methods Between January 2014 and December 2016, the results of cranial computed tomography imaging within 24 h after the onset of symptoms from 275 patients with ICH were retrospectively analyzed. The patients with or without blend sign were compared to observe and analyze the difference in coagulation function abnormality, rebleeding, mortality, and bad prognosis rates in the early stages. Results Of the 275 patients with ICH, 47 patients had Blend Sign I (17.09%) and 17 patients had Blend Sign II (6.18%). The coagulation function abnormality rate had no statistical difference among Blend Sign I, Blend Sign II, and conventional groups (P > 0.05). In the Blend Sign I group, the rebleeding rate was 4.26%, bad prognosis rate was 25.53%, and mortality rate was 6.38%, which were not statistically significantly different compared with those in the conventional group (P > 0.05). The rebleeding rate in the Blend Sign II group was 47.06%, bad prognosis rate was 82.35%, and mortality rate was 47.06%, which were statistically significantly different compared with those in the conventional and Blend Sign I groups (P < 0.05). Conclusions For the patients associated with Blend Sign I, the prognosis was equivalent to that in the conventional group, with no statistically significant difference. The rebleeding, bad prognosis, and mortality rates were higher in the Blend Sign II group than in the conventional group and deserved more attention.

The analysis of critical cooling rate for high-rise building steel S460

NASA Astrophysics Data System (ADS)

Lu, Shiping; Chen, Xia; Li, Qun; Wang, Haibao; Gu, Linhao

2017-09-01

High-rise building steel S460 is an important structure steel.The product process of the steel is Quenching&Tempering. The critical cooling rate of steel is very important in heavy plate quenching process, and it is also the basis of the cooling process[1].The critical cooling rate of HSLA steel S460 is obtained from the Thermal simulation method,and the differences about the microstructure and properties of different cooling rate is also analyzed.In this article, the angle of the grain boundary and the average grain size are analyzed by EBSD under different cooling rate. The relationship between grain boundary angle and grain size with the cooling rate is obtained. According to the experiment,it provides the basis for the formulation of the quenching process of the industrial production.

12 CFR 226.6 - Account-opening disclosures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... received after the time period's expiration. (ii) A disclosure of each periodic rate that may be used to... effect(s) of an increase. When different periodic rates apply to different types of transactions, the types of transactions to which the periodic rates shall apply shall also be disclosed. A creditor is not...

12 CFR 226.6 - Account-opening disclosures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... received after the time period's expiration. (ii) A disclosure of each periodic rate that may be used to... effect(s) of an increase. When different periodic rates apply to different types of transactions, the types of transactions to which the periodic rates shall apply shall also be disclosed. A creditor is not...

Southeastern U.S.A. Continental Shelf Respiratory Rates Revisited

NASA Technical Reports Server (NTRS)

Sheldon, Joan E.; Griffith, Peter C.; Peters Francesc; Sheldon, Wade M., Jr.; Blanton, Jackson O.; Amft, Julie; Pomeroy, Lawrence R.

2010-01-01

Respiratory rates on the U. S. southeastern continental shelf have been estimated several times by different investigators, most recently by Jiang et al. (Biogeochemistry 98:101-113, 2010) who report lower mean rates thanwere found in earlier work and attribute the differences to analytical error in all methods used in earlier studies. The differences are, instead, attributable to the differences in the geographical scope of the studies. The lower estimates of regional organic carbon flux of Jiang et al. (Biogeochemistry 98:101-113, 2010) are a consequence of their extrapolation of data from a small portion of the shelf to the entire South Atlantic Bight. This comment examines the methodologies used as well as the variability of respiratory rates in this region over space and time.

Rash rates with egfr inhibitors: meta-analysis

PubMed Central

Mittmann, N.; Seung, S.J.

2011-01-01

Introduction Currently marketed epidermal growth factor receptor inhibitors (egfris) have been associated with high rates of dermatologic toxicity. Methods We formally reviewed the literature at medline and embase. Additional searches were conducted using Internet search engines. Studies were eligible if they were randomized controlled clinical trials of egfris, specifically cetuximab and panitumumab, in which at least one arm consisted of a non-egfri treatment and rash safety data were reported. The random effects method was used to pool differences in incident rash rates. Results are summarized as differences in incident rash (egfri therapy rate minus the non-egfri therapy rate) with corresponding 95% confidence intervals (cis) for all severity grades of rash and for grades 3 and 4 rash. Results Sixteen studies met the initial inclusion criteria of randomized controlled trials comparing egfri with non-egfri therapy. Seven publications that provided information on all severity grades of rash were found to have an overall difference in incident rash rate of 0.74 (95% ci: 0.68 to 0.81; p < 0.01). Thirteen studies that reported the incidence of grades 3 and 4 rash showed an overall difference in the incident rash rate of 0.12 (95% ci: 0.09 to 0.14; p < 0.01) between egfri and non-egfri therapy. Sensitivity analyses showed that the results were generally robust, but sensitive to small samples. Conclusions Results quantify the difference in rash rates between egfri and non-egfri therapy. PMID:21505590

Seasonal variations in modern speleothem calcite growth in Central Texas, U.S.A

USGS Publications Warehouse

Banner, J.L.; Guilfoyle, A.; James, E.W.; Stern, L.A.; Musgrove, M.

2007-01-01

Variations in growth rates of speleothem calcite have been hypothesized to reflect changes in a range of paleoenvironmental variables, including atmospheric temperature and precipitation, drip-water composition, and the rate of soil CO2 delivery to the subsurface. To test these hypotheses, we quantified growth rates of modern speleothem calcite on artificial substrates and monitored concurrent environmental conditions in three caves across the Edwards Plateau in central Texas. Within each of two caves, different drip sites exhibit similar annual cycles in calcite growth rates, even though there are large differences between the mean growth rates at the sites. The growth-rate cycles inversely correlate to seasonal changes in regional air temperature outside the caves, with near-zero growth rates during the warmest summer months, and peak growth rates in fall through spring. Drip sites from caves 130 km apart exhibit similar temporal patterns in calcite growth rate, indicating a controlling mechanism on at least this distance. The seasonal variations in calcite growth rate can be accounted for by a primary control by regional temperature effects on ventilation of cave-air CO2 concentrations and/or drip-water CO2 contents. In contrast, site-to-site differences in the magnitude of calcite growth rates within an individual cave appear to be controlled principally by differences in drip rate. A secondary control by drip rate on the growth rate temporal variations is suggested by interannual variations. No calcite growth was observed in the third cave, which has relatively high values of and small seasonal changes in cave-air CO2. These results indicate that growth-rate variations in ancient speleothems may serve as a paleoenvironmental proxy with seasonal resolution. By applying this approach of monitoring the modern system, speleothem growth rate and geochemical proxies for paleoenviromnental change may be evaluated and calibrated. Copyright ?? 2007, SEPM (Society for Sedimentary Geology).

Helicopter emergency medical services accident rates in different international air rescue systems

PubMed Central

Hinkelbein, J; Schwalbe, M; Genzwuerker, HV

2010-01-01

Aim Each year approximately two to four helicopter emergency medical services (HEMS) crashes occur in Germany. The aim of the present study was to compare crash rates and fatal crash rates in Germany to rates in other countries. Materials and methods A MEDLINE search from 1970 to 2009 was performed using combinations of the keywords “HEMS”, “rescue helicopter”, “accident”, “accident rate”, “crash”, and “crash rate”. The search was supplemented by additional published data. Data were compared on the basis of 10,000 missions and 100,000 helicopter flying hours. These data were allocated to specific time frames for analyis. Results Eleven relevant studies were identified. Five studies (three from Germany, one from the US, one from Australia) analyzing HEMS accidents on the basis of 10,000 missions were identified. Crash rates per 10,000 missions ranged between 0.4 and 3.05 and fatal crash rates between 0.04 and 2.12. In addition, nine studies (six from the US, two from Germany, one from Australia) used 100,000 flying hours as a denominator. Here, crash rates ranged between 1.7 and 13.4 and fatal crash rates between 0.91 and 4.7. Conclusions Data and accident rates were inhomogeneous and differed significantly. Data analysis was impeded by publication of mean data, use of different time frames, and differences in HEMS systems. PMID:27147837

Prolongation of heart rate-corrected QT interval is a predictor of cardiac autonomic dysfunction in patients with systemic lupus erythematosus.

PubMed

Nomura, Atsushi; Kishimoto, Mitsumasa; Takahashi, Osamu; Deshpande, Gautam A; Yamaguchi, Kenichi; Okada, Masato

2014-05-01

Heart rate-corrected QT interval duration (QTc) has been shown to be related to cardiac autonomic dysfunction in patients with diabetes mellitus, although this association has not been previously described in patients with systemic lupus erythematosus (SLE). We retrospectively reviewed the medical records of 91 SLE patients and 144 non-SLE connective tissue disease patients visiting our clinic from November 2010 to April 2011. We compared ambulatory heart rate identified by pulse measured by automated machine in an outpatient waiting area versus resting heart rate identified on prior screening electrocardiogram. Heart rate differences were analyzed in relation to QTc interval and other characteristics. Ambulatory and resting heart rate differences were larger among SLE patients with QTc prolongation (QTc > 430 ms) than those without QTc prolongation (mean difference, 15.9 vs. 9.6, p = 0.001). In multivariate analysis, differences in heart rate were associated with QTc prolongation (OR 1.10, 95 % CI 1.01-1.21; p = 0.038), independent of age, duration of disease, immunosuppressant use, hydroxychloroquine use, diabetes mellitus, cardiac abnormality, anti-Ro/SS-A antibody positivity, or resting heart rate. Cardiac autonomic dysfunction is a common manifestation of SLE and may be related to QTc prolongation.

National mortality rates: the impact of inequality?

PubMed

Wilkinson, R G

1992-08-01

Although health is closely associated with income differences within each country there is, at best, only a weak link between national mortality rates and average income among the developed countries. On the other hand, there is evidence of a strong relationship between national mortality rates and the scale of income differences within each society. These three elements are coherent if health is affected less by changes in absolute material standards across affluent populations than it is by relative income or the scale of income differences and the resulting sense of disadvantage within each society. Rather than socioeconomic mortality differentials representing a distribution around given national average mortality rates, it is likely that the degree of income inequality indicates the burden of relative deprivation on national mortality rates.

Self-Evaluation Processes in Life Satisfaction: Uncovering Measurement Non-Equivalence and Age-Related Differences

ERIC Educational Resources Information Center

Heidemeier, Heike; Staudinger, Ursula M.

2012-01-01

This study demonstrates how self-evaluation processes explain subgroup differences in ratings of life satisfaction (population heterogeneity). Life domains differ with regard to the constraints they impose on beliefs in internal control. We hypothesized that these differences are linked with cognitive biases in ratings of life satisfaction. In…

Sound envelope encoding in the auditory cortex revealed by neuromagnetic responses in the theta to gamma frequency bands.

PubMed

Miyazaki, Takahiro; Thompson, Jessica; Fujioka, Takako; Ross, Bernhard

2013-04-19

Amplitude fluctuations of natural sounds carry multiple types of information represented at different time scales, such as syllables and voice pitch in speech. However, it is not well understood how such amplitude fluctuations at different time scales are processed in the brain. In the present study we investigated the effect of the stimulus rate on the cortical evoked responses using magnetoencephalography (MEG). We used a two-tone complex sound, whose envelope fluctuated at the difference frequency and induced an acoustic beat sensation. When the beat rate was continuously swept between 3Hz and 60Hz, auditory evoked response showed distinct transient waves at slow rates, while at fast rates continuous sinusoidal oscillations similar to the auditory steady-state response (ASSR) were observed. We further derived temporal modulation transfer functions (TMTF) from amplitudes of the transient responses and from the ASSR. The results identified two critical rates of 12.5Hz and 25Hz, at which consecutive transient responses overlapped with each other. These stimulus rates roughly corresponded to the rates at which the perceptual quality of the sound envelope is known to change. Low rates (> 10Hz) are perceived as loudness fluctuation, medium rates as acoustical flutter, and rates above 25Hz as roughness. We conclude that these results reflect cortical processes that integrate successive acoustic events at different time scales for extracting complex features of natural sound. Copyright © 2013 Elsevier B.V. All rights reserved.

Persistent Sex Disparities in Invasive Pneumococcal Diseases in the Conjugate Vaccine Era.

PubMed

de St Maurice, Annabelle; Schaffner, William; Griffin, Marie R; Halasa, Natasha; Grijalva, Carlos G

2016-09-01

Few studies have characterized the role of sex on the incidence of invasive pneumococcal disease (IPD). We examined sex differences in rates of IPD, and trends after the introduction of pneumococcal conjugate vaccines (PCVs). We used active population and laboratory-based IPD surveillance data from the Centers for Disease Control and Prevention Active Bacterial Core surveillance program (1998-2013) in Tennessee. Population-based rates of IPD by sex, race, age group, and PCV era were calculated. Rates were compared using incidence rate ratios. Throughout the study years, rates of IPD were higher in male than in female subjects, particularly in children <2 years and adults 40-64 years of age, with male subjects having IPD rates 1.5-2 times higher than female subjects. The proportions of comorbid conditions were similar in male and female subjects . Sex rate differences persisted after stratification by race. Although the introductions of 7-valent PCV (PCV7) and 13-valent PCV (PCV13) were associated with declines in IPD rates in both sexes, rates of IPD after PCV13 were still significantly higher in male than in female subjects among children and adults 40-64 and >74 years of age. Rates of IPD were generally higher in male than in female subjects. These sex differences were observed in different race groups and persisted after introduction of both PCVs. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.