Science.gov

Sample records for real options perspective

  1. Making real options really work.

    PubMed

    van Putten, Alexander B; MacMillan, Ian C

    2004-12-01

    As a way to value growth opportunities, real options have had a difficult time catching on with managers. Many CFOs believe the method ensures the overvaluation of risky projects. This concern is legitimate, but abandoning real options as a valuation model isn't the solution. Companies that rely solely on discounted cash flow (DCF) analysis underestimate the value of their projects and may fail to invest enough in uncertain but highly promising opportunities. CFOs need not--and should not--choose one approach over the other. Far from being a replacement for DCF analysis, real options are an essential complement, and a project's total value should encompass both. DCF captures a base estimate of value; real options take into account the potential for big gains. This is not to say that there aren't problems with real options. As currently applied, they focus almost exclusively on the risks associated with revenues, ignoring the risks associated with a project's costs. It's also true that option valuations almost always ignore assets that an initial investment in a subsequently abandoned project will often leave the company. In this article, the authors present a simple formula for combining DCF and option valuations that addresses these two problems. Using an integrated approach, managers will, in the long run, select better projects than their more timid competitors while keeping risk under control. Thus, they will outperform their rivals in both the product and the capital markets.

  2. Electric retail market options: The customer perspective

    SciTech Connect

    Hadley, S.W.; Hillsman, E.L.

    1995-07-01

    This report describes various options that are now available for retail electric customers, or that may become available during the next few years as the electric utility industry restructures. These options include different ways of meeting demand for energy services, different providers of service or points of contact with providers, and different pricing structures for purchased services. Purpose of this document is to examine these options from the customer`s perspective: how might being a retail electric customer in 5--10 years differ from now? Seizing opportunities to reduce cost of electric service is likely to entail working with different service providers; thus, transaction costs are involved. Some of the options considered are speculative. Some transitional options include relocation, customer-built/operated transmission lines, municipalization, self-generation, and long-term contracts with suppliers. All these may change or diminish in a restructured industry. Brokers seem likely to become more common unless restructuring takes the form of mandatory poolcos (wholesale). Some options appear robust, ie, they are likely to become more common regardless of how restructuring is accomplished: increased competition among energy carriers (gas vs electric), real-time pricing, etc. This report identified some of the qualitative differences among the various options. For customers using large amounts of electricity, different alternatives are likely to affect greatly service price, transaction costs, tailoring service to customer preferences, and risks for customer. For retail customers using small amounts of electricity, there may be little difference among the options except service price.

  3. Perspective on our energy options

    NASA Astrophysics Data System (ADS)

    Scott, J. H.

    The United States is going to have to depend on an increasing mix of energy recovery and conversion processes, and they all have problems. These problems are discussed from the perspective of a national laboratory which has had the opportunity to conduct research and development on many of the options. Energy options discussed are: energy conservation; liquid fuels and how to acquire the needed supply (from kerogen, enhanced oil recovery, coal liquefaction); use of natural gas; geothermal energy sources; wind and solar energy; and nuclear power.

  4. Real options reasoning in healthcare: an integrative approach and synopsis.

    PubMed

    Williams, David R; Hammes, Paul H

    2007-01-01

    For the past 40 years, practitioners and researchers alike have been grappling with the natural shortcomings associated with the net present value approach to strategic decision making and capital budgeting. Work by scholars in option pricing theory has evolved into an alternative perspective on strategic capital investments, called "real options." Proponents of real options argue that this is a superior way of approaching decision making and capital budgeting, compared with other approaches, as it allows for greater strategic flexibility and encourages exploration, experimentation, and innovation. Within the healthcare literature, articles on real options have focused on pricing these options. This article is unique to the healthcare literature as it emphasizes the cognitive or strategic aspects of real options. Additionally, this article integrates two techniques for applying the real options approach for interested practitioners using a hospital's imaging department as an example, while providing scholars with additional applications and questions for future research. For practitioners, the implications are that thinking of and planning for capital investments as real options may create greater strategic and operating flexibility than other, more traditional approaches.

  5. A real-world way to manage real options.

    PubMed

    Copeland, Tom; Tufano, Peter

    2004-03-01

    Each corporate growth project is an option, in the sense that managers face choices--push ahead or pull back--along the way. Yet many companies hesitate to apply options theory to initiatives such as R&D and geographic expansion, partly because these "real" options are highly complex. In this article, the authors make the case that the complexity of real options can be eased through the use of a binomial valuation model. Many of the problems with real-options analysis stem from the use of the Black-Scholes-Merton model, which isn't suited to real options. Binomial models, by contrast, are simpler mathematically, and you can tinker with a binomial model until it closely reflects the project you wish to value. Suppose your company is considering investing in a new plant. To use the binomial model, you must create an "event tree" to figure out the full range of possible values for the plant during the project's lifetime--next year, at the end of the design phase, upon completion. Then you work backward from the value at completion, factoring in the various investments, to determine the value of the project today. These calculations provide you with numbers for all the possible future values of the option at the various points where a decision needs to be made on whether to continue with the project. The authors also address another criticism of real options: that gaps often arise between theoretical and realized values of options of all types. Such gaps may be largely the result of managers exercising options at the wrong time. To improve the way it manages its real options, a company can look out for the decision trigger points that correspond to the nodes on a binomial decision tree. The trigger points should not only tell managers when they need to decide on exercise but also specify rules governing the exercise decisions.

  6. Strategy as a portfolio of real options.

    PubMed

    Luehrman, T A

    1998-01-01

    In financial terms, a business strategy is much more like a series of options than like a single projected cash flow. Executing a strategy almost always involves making a sequence of major decisions. Some actions are taken immediately while others are deliberately deferred so that managers can optimize their choices as circumstances evolve. While executives readily grasp the analogy between strategy and real options, until recently the mechanics of option pricing was so complex that few companies found it practical to use when formulating strategy. But advances in both computing power and our understanding of option pricing over the last 20 years now make it feasible to apply real-options thinking to strategic decision making. To analyze a strategy as a portfolio of related real options, this article exploits a framework presented by the author in "Investment Opportunities as Real Options: Getting Started on the Numbers" (HBR July-August 1998). That article explained how to get from discounted-cash-flow value to option value for a typical project; in other words, it was about reaching a number. This article extends that framework, exploring how, once you've worked out the numbers, you can use option pricing to improve decision making about the sequence and timing of a portfolio of strategic investments. Timothy Luehrman shows executives how to plot their strategies in two-dimensional "option space," giving them a way to "draw" a strategy in terms that are neither wholly strategic nor wholly financial, but some of both. Such pictures inject financial discipline and new insight into how a company's future opportunities can be actively cultivated and harvested.

  7. Acquiring Technical Data With Renewable Real Options

    DTIC Science & Technology

    2016-04-30

    source of cost avoidance to the government. Decision Tree for Technical Data Options In Phases 3 and 4 of our technical data acquisition method...avoidance associated with various government uses, summed across the remaining years of the life cycle. We can represent this as a decision tree , as...during the year whether to exercise an option based on operational needs. Iterative Decision Tree Decision trees are evaluated by working

  8. Flexibility and Project Value: Interactions and Multiple Real Options

    NASA Astrophysics Data System (ADS)

    Čulík, Miroslav

    2010-06-01

    This paper is focused on a project valuation with embedded portfolio of real options including their interactions. Valuation is based on the criterion of Net Present Value on the simulation basis. Portfolio includes selected types of European-type real options: option to expand, contract, abandon and temporarily shut down and restart a project. Due to the fact, that in reality most of the managerial flexibility takes the form of portfolio of real options, selected types of options are valued not only individually, but also in combination. The paper is structured as follows: first, diffusion models for forecasting of output prices and variable costs are derived. Second, project value is estimated on the assumption, that no real options are present. Next, project value is calculated with the presence of selected European-type options; these options and their impact on project value are valued first in isolation and consequently in different combinations. Moreover, intrinsic value evolution of given real options with respect to the time of exercising is analysed. In the end, results are presented graphically; selected statistics and risk measures (Value at Risk, Expected Shortfall) of the NPV's distributions are calculated and commented.

  9. The Implications of Real Options on ERP-Enabled Adoption

    ERIC Educational Resources Information Center

    Nwankpa, Joseph K.

    2012-01-01

    Current research on Enterprise Resource Planning (ERP) systems and real options focuses on valuation and justification issues that manager's face prior to project approval with existing literature attempting to demonstrate that ERP systems as technology positioning investments have option-like characteristics thus making such ERP systems…

  10. The Implications of Real Options on ERP-Enabled Adoption

    ERIC Educational Resources Information Center

    Nwankpa, Joseph K.

    2012-01-01

    Current research on Enterprise Resource Planning (ERP) systems and real options focuses on valuation and justification issues that manager's face prior to project approval with existing literature attempting to demonstrate that ERP systems as technology positioning investments have option-like characteristics thus making such ERP systems…

  11. Temporary Employment Contracts in Academia: A Real Option View

    ERIC Educational Resources Information Center

    Brady, Malcolm

    2017-01-01

    This paper examines the strategic use of temporary employment contracts in dealing with supply uncertainty in the form of employee ability that is slow to reveal itself, for example in academia where there exist significant time lags in demonstration of research ability. A temporary contract is modeled as a real option, specifically as a…

  12. Real Options in Defense R and D: A Decision Tree Analysis Approach for Options to Defer, Abandon, and Expand

    DTIC Science & Technology

    2016-12-01

    uncertain and risky conditions As for the taxonomy , real options are generally named after the specific functions they play and the type of...abandon, switch, and grow. Benaroch (2001) provides an even more detailed taxonomy by defining 13 different types of real options in technology...models—that is the Black-Scholes Model (1973) and the Binomial Model (Cox et al., 1979). I also analyzed the taxonomy of real options and defined options

  13. Pricing real estate index options under stochastic interest rates

    NASA Astrophysics Data System (ADS)

    Gong, Pu; Dai, Jun

    2017-08-01

    Real estate derivatives as new financial instruments are not merely risk management tools but also provide a novel way to gain exposure to real estate assets without buying or selling the physical assets. Although real estate derivatives market has exhibited a rapid development in recent years, the valuation challenge of real estate derivatives remains a great obstacle for further development in this market. In this paper, we derive a partial differential equation contingent on a real estate index in a stochastic interest rate environment and propose a modified finite difference method that adopts the non-uniform grids to solve this problem. Numerical results confirm the efficiency of the method and indicate that constant interest rate models lead to the mispricing of options and the effects of stochastic interest rates on option prices depend on whether the term structure of interest rates is rising or falling. Finally, we have investigated and compared the different effects of stochastic interest rates on European and American option prices.

  14. Using real options analysis to support strategic management decisions

    NASA Astrophysics Data System (ADS)

    Kabaivanov, Stanimir; Markovska, Veneta; Milev, Mariyan

    2013-12-01

    Decision making is a complex process that requires taking into consideration multiple heterogeneous sources of uncertainty. Standard valuation and financial analysis techniques often fail to properly account for all these sources of risk as well as for all sources of additional flexibility. In this paper we explore applications of a modified binomial tree method for real options analysis (ROA) in an effort to improve decision making process. Usual cases of use of real options are analyzed with elaborate study on the applications and advantages that company management can derive from their application. A numeric results based on extending simple binomial tree approach for multiple sources of uncertainty are provided to demonstrate the improvement effects on management decisions.

  15. Real options analysis for photovoltaic project under climate uncertainty

    NASA Astrophysics Data System (ADS)

    Kim, Kyeongseok; Kim, Sejong; Kim, Hyoungkwan

    2016-08-01

    The decision on photovoltaic project depends on the level of climate environments. Changes in temperature and insolation affect photovoltaic output. It is important for investors to consider future climate conditions for determining investments on photovoltaic projects. We propose a real options-based framework to assess economic feasibility of photovoltaic project under climate change. The framework supports investors to evaluate climate change impact on photovoltaic projects under future climate uncertainty.

  16. The manuscript option dissertation: multiple perspectives.

    PubMed

    De Jong, Marla J; Moser, Debra K; Hall, Lynne A

    2005-01-01

    Based on our experiences at the University of Kentucky, the manuscript option dissertation is clearly a win-win situation from every angle. Other doctoral programs may find this approach invigorating. The ultimate benefit is the rapid dissemination of new knowledge to healthcare professionals for application to practice.

  17. Applying Real Options for Evaluating Investments in ERP Systems

    NASA Astrophysics Data System (ADS)

    Nakagane, Jun; Sekozawa, Teruji

    This paper intends to verify effectiveness of real options approach for evaluating investments in Enterprise Resource Planning systems (ERP) and proves how important it is to disclose shadow options potentially embedded in ERP investment. The net present value (NPV) method is principally adopted to evaluate the value of ERP. However, the NPV method assumes no uncertainties exist in the object. It doesn't satisfy the current business circumstances which are filled with dynamic issues. Since the 1990s the effectiveness of option pricing models for Information System (IS) investment to solve issues in the NPV method has been discussed in the IS literature. This paper presents 3 business cases to review the practical advantages of such techniques for IS investments, especially ERP investments. The first case is EDI development. We evaluate the project by a new approach with lighting one of shadow options, EDI implementation. In the second case we reveal an ERP investment has an “expanding option” in a case of eliminating redundancy. The third case describes an option to contract which is deliberately slotted in ERP development to prepare transferring a manufacturing facility.

  18. Real Option Cost Vulnerability Analysis of Electrical Infrastructure

    NASA Astrophysics Data System (ADS)

    Prime, Thomas; Knight, Phil

    2015-04-01

    Critical infrastructure such as electricity substations are vulnerable to various geo-hazards that arise from climate change. These geo-hazards range from increased vegetation growth to increased temperatures and flood inundation. Of all the identified geo-hazards, coastal flooding has the greatest impact, but to date has had a low probability of occurring. However, in the face of climate change, coastal flooding is likely to occur more often due to extreme water levels being experienced more frequently due to sea-level rise (SLR). Knowing what impact coastal flooding will have now and in the future on critical infrastructure such as electrical substations is important for long-term management. Using a flood inundation model, present day and future flood events have been simulated, from 1 in 1 year events up to 1 in 10,000 year events. The modelling makes an integrated assessment of impact by using sea-level and surge to simulate a storm tide. The geographical area the model covers is part of the Northwest UK coastline with a range of urban and rural areas. The ensemble of flood maps generated allows the identification of critical infrastructure exposed to coastal flooding. Vulnerability has be assessed using an Estimated Annual Damage (EAD) value. Sampling SLR annual probability distributions produces a projected "pathway" for SLR up to 2100. EAD is then calculated using a relationship derived from the flood model. Repeating the sampling process allows a distribution of EAD up to 2100 to be produced. These values are discounted to present day values using an appropriate discount rate. If the cost of building and maintain defences is also removed from this a Net Present Value (NPV) of building the defences can be calculated. This distribution of NPV can be used as part of a cost modelling process involving Real Options, A real option is the right but not obligation to undertake investment decisions. In terms of investment in critical infrastructure resilience this

  19. Evaluation of Foreign Investment in Power Plants using Real Options

    NASA Astrophysics Data System (ADS)

    Kato, Moritoshi; Zhou, Yicheng

    This paper proposes new methods for evaluating foreign investment in power plants under market uncertainty using a real options approach. We suppose a thermal power plant project in a deregulated electricity market. One of our proposed methods is that we calculate the cash flow generated by the project in a reference year using actual market data to incorporate periodic characteristics of energy prices into a yearly cash flow model. We make the stochastic yearly cash flow model with the initial value which is the cash flow in the reference year, and certain trend and volatility. Then we calculate the real options value (ROV) of the project which has abandonment options using the yearly cash flow model. Another our proposed method is that we evaluate foreign currency/domestic currency exchange rate risk by representing ROV in foreign currency as yearly pay off and exchanging it to ROV in domestic currency using a stochastic exchange rate model. We analyze the effect of the heat rate and operation and maintenance costs of the power plant on ROV, and evaluate exchange rate risk through numerical examples. Our proposed method will be useful for the risk management of foreign investment in power plants.

  20. Real options and asset valuation in competitive energy markets

    NASA Astrophysics Data System (ADS)

    Oduntan, Adekunle Richard

    The focus of this work is to develop a robust valuation framework for physical power assets operating in competitive markets such as peaking or mid-merit thermal power plants and baseload power plants. The goal is to develop a modeling framework that can be adapted to different energy assets with different types of operating flexibilities and technical constraints and which can be employed for various purposes such as capital budgeting, business planning, risk management and strategic bidding planning among others. The valuation framework must also be able to capture the reality of power market rules and opportunities, as well as technical constraints of different assets. The modeling framework developed conceptualizes operating flexibilities of power assets as "switching options' whereby the asset operator decides at every decision point whether to switch from one operating mode to another mutually exclusive mode, within the limits of the equipment constraints of the asset. As a current decision to switch operating modes may affect future operating flexibilities of the asset and hence cash flows, a dynamic optimization framework is employed. The developed framework accounts for the uncertain nature of key value drivers by representing them with appropriate stochastic processes. Specifically, the framework developed conceptualizes the operation of a power asset as a multi-stage decision making problem where the operator has to make a decision at every stage to alter operating mode given currently available information about key value drivers. The problem is then solved dynamically by decomposing it into a series of two-stage sub-problems according to Bellman's optimality principle. The solution algorithm employed is the Least Squares Monte Carlo (LSM) method. The developed valuation framework was adapted for a gas-fired thermal power plant, a peaking hydroelectric power plant and a baseload power plant. This work built on previously published real options valuation

  1. Corporate social responsibility: a real options approach to the challenge of financial sustainability.

    PubMed

    Bosch-Badia, Maria-Teresa; Montllor-Serrats, Joan; Tarrazon-Rodon, Maria-Antonia

    2015-01-01

    In contemporary complex societies, social values like ethics, corporate social responsibility, and being respectful with the environment, among others, are becoming social requirements. Corporations are expected to fulfill them and, according to empirical evidence, an overwhelming majority aspires to good social valuation. At the same time, the maximization of market share value in the long run continues to be the central corporate goal. Making environmental and social expenses compatible with value creation is a central challenge for corporations since it implies the financial sustainability of Corporate Social Responsibility (CSR). The value creation capacity of CSR projects, mainly through innovation, is widely acknowledged in economic literature and corporate practice. This fact arouses the need of having a quantitative framework capable of summarizing the value creation capacity of the variables involved in CSR projects. With this aim we build up a sensitivity analysis of real option ratios that studies and quantifies the value creation capacity of CSR projects connected with innovation. Ratio analysis has the advantage of being scale independent. Hence, it furnishes a homogeneous framework to express the interaction of value creation variables and, thus, supports strategic thinking quantitatively. Often, CSR expenses can be regarded as preliminary projects that create the opportunity to undertake a full future project. For them, we obtain the minimum expectations scenario that makes financially sustainable a preliminary project that can be interpreted as a call option. We propose a classification of CSR projects from the decision analysis perspective following a two-fold approach: Their relationship with value creation and their links with existing corporate activities. This classification of CSR projects aims at contributing to choose the best capital budgeting method to study the financial sustainability of the project and identifying those CSR projects

  2. Corporate Social Responsibility: A Real Options Approach to the Challenge of Financial Sustainability

    PubMed Central

    2015-01-01

    Background In contemporary complex societies, social values like ethics, corporate social responsibility, and being respectful with the environment, among others, are becoming social requirements. Corporations are expected to fulfill them and, according to empirical evidence, an overwhelming majority aspires to good social valuation. At the same time, the maximization of market share value in the long run continues to be the central corporate goal. Making environmental and social expenses compatible with value creation is a central challenge for corporations since it implies the financial sustainability of Corporate Social Responsibility (CSR). Methods and Results The value creation capacity of CSR projects, mainly through innovation, is widely acknowledged in economic literature and corporate practice. This fact arouses the need of having a quantitative framework capable of summarizing the value creation capacity of the variables involved in CSR projects. With this aim we build up a sensitivity analysis of real option ratios that studies and quantifies the value creation capacity of CSR projects connected with innovation. Ratio analysis has the advantage of being scale independent. Hence, it furnishes a homogeneous framework to express the interaction of value creation variables and, thus, supports strategic thinking quantitatively. Often, CSR expenses can be regarded as preliminary projects that create the opportunity to undertake a full future project. For them, we obtain the minimum expectations scenario that makes financially sustainable a preliminary project that can be interpreted as a call option. We propose a classification of CSR projects from the decision analysis perspective following a two-fold approach: Their relationship with value creation and their links with existing corporate activities. This classification of CSR projects aims at contributing to choose the best capital budgeting method to study the financial sustainability of the project and

  3. Energy options: real economics and the solar-hydrogen system

    SciTech Connect

    Bockris, J.O'M.

    1980-01-01

    All price comparisons being made at present, upon which energy decisions only effective decades later are being made, are irelevant, the author feels. The relevant economics is that of the time beyond the year 2000, when the fossil fuels will be playing a diminishing role in the energy mix, at energy prices greatly above those of the present time. This book attempts to put numbers in the various years concerned, and to discuss now the financing. It shows that the coal-nuclear policy, which is the basis of the present energy thrust in research and in financing, is incompatible with environmental and health considerations. However, Prof. Bockris notes that the alternatives are not those of having nuclear energy or having gross unemployment, but rather those of having nuclear energy or solar energy on a massive scale by means of collection in desert areas. Solar energy is not primarily a source for rooftops and water heating, but one which could supply factories, industries, commerce and transportation. The key to the difference in viewpoint is the introduction of hydrogen as a transmission, storage, and distribution medium, the hydrogen coming from the electrolysis of water, and the electricity for this coming from the solar source. The title of the book arises because of the newly introduced subjects of the Second Law economics and the real economics which takes into account the Second Law cost, but also the differing cost of health with each alternative-energy system. It is only if one takes into account economics from the point of view of the consumer of the energy that the relevant order of preference of the various energy options can be ascertained. 526 references, 148 figures, 94 tables.

  4. A real options approach to clinical faculty salary structure.

    PubMed

    Kahn, Marc J; Long, Hugh W

    2012-01-01

    One can use the option theory model originally developed to price financial opportunities in security markets to analyze many other economic arrangements such as the salary structures of clinical faculty in an academic medical center practice plan. If one views the underlying asset to be the portion (labeled "salary") of the economic value of the collections made for the care provided patients by the physician, then a salary guarantee can be considered a put option provided the physician, the guarantee having value to the physician only when the actual salary earned is less than the salary guarantee. Similarly, within an incentive plan, a salary cap can be thought of as a call option provided to the practice plan since a salary cap only has value to the practice plan when a physician's earnings exceed the cap. Further, based on analysis of prior earnings, the Black-Scholes options pricing model can be used both to price each option and to determine a financially neutral balance between a salary guarantee and a salary cap by equating the prices of the implied put and call options. We suggest that such analysis is superior to empirical methods for setting clinical faculty salary structure in the academic practice plan setting.

  5. Acquiring Enterprise Systems as a Portfolio of Real Options

    DTIC Science & Technology

    2012-04-30

    decision flexibility and acquire the target architecture?s capabilities at lower cost and risk. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17...contribute an approach to value a portfolio of projects that intentionally creates options to preserve decision flexibility and acquire the target...priorities and to align business transformation. The five core business missions are financial management (FM), human resource management ( HRM ), material

  6. A Real Options Approach to Quantity and Cost Optimization for Lifetime and Bridge Buys of Parts

    DTIC Science & Technology

    2015-12-01

    and bridge buys, which are used to manage part discontinuance (i.e., obsolescence) during the support of critical systems are simple in concept, the...stochastic discrete event simulation (DES). The real options analysis methodology is used to address several questions:  What is the critical ...initial buy size that drives the option at the money?  What are the critical penalty costs (under buy, overbuy, and holding cost) that drive the option at

  7. An Economic Evaluation on Replacement Plan for Aged Thermal Power Plants through a Real Option Approach

    NASA Astrophysics Data System (ADS)

    Kato, Moritoshi; Zhou, Yicheng

    This paper presents a novel method to evaluate replacement plan for aged thermal power plants under uncertain circumstances through a real option approach. The most economical plan is selected among the three options: an option to operate an existing oil-fired thermal plant, an option to mothball it, and an option to abandon it and to construct an advanced gas combined cycle power plant (ACC) at the same time. Basic ideas of our model are: we use quadranomial approach in order to evaluate an option value consisted by two different uncertain assets; we consider cash flow with a dividend in order to reflect conditions of an aged oil-fired thermal plant and use the sequential compound option approach; we evaluate replacement time using quadranomial decision tree taking into account the options. We also analyze value and time of replacement using numerical examples. Our proposed method will be practically used for generation planning. For example it is possible to make priority quantitatively in replacements of aged thermal power plants by real option values. The target year of replacement may be set as a year when cumulative probability of replacement becomes over certain level.

  8. Real options analysis for land use management: Methods, application, and implications for policy.

    PubMed

    Regan, Courtney M; Bryan, Brett A; Connor, Jeffery D; Meyer, Wayne S; Ostendorf, Bertram; Zhu, Zili; Bao, Chenming

    2015-09-15

    Discounted cash flow analysis, including net present value is an established way to value land use and management investments which accounts for the time-value of money. However, it provides a static view and assumes passive commitment to an investment strategy when real world land use and management investment decisions are characterised by uncertainty, irreversibility, change, and adaptation. Real options analysis has been proposed as a better valuation method under uncertainty and where the opportunity exists to delay investment decisions, pending more information. We briefly review the use of discounted cash flow methods in land use and management and discuss their benefits and limitations. We then provide an overview of real options analysis, describe the main analytical methods, and summarize its application to land use investment decisions. Real options analysis is largely underutilized in evaluating land use decisions, despite uncertainty in policy and economic drivers, the irreversibility and sunk costs involved. New simulation methods offer the potential for overcoming current technical challenges to implementation as demonstrated with a real options simulation model used to evaluate an agricultural land use decision in South Australia. We conclude that considering option values in future policy design will provide a more realistic assessment of landholder investment decision making and provide insights for improved policy performance.

  9. Decision analysis and drug development portfolio management: uncovering the real options value of your projects.

    PubMed

    Rosati, Nicoletta

    2002-04-01

    Project selection and portfolio management are particularly challenging in the pharmaceutical industry due to the high risk - high stake nature of the drug development process. In the recent years, scholars and industry experts have agreed that traditional Net-Present-Value evaluation of the projects fails to capture the value of managerial flexibility, and encouraged adopting a real options approach to recover the missed value. In this paper, we take a closer look at the drug development process and at the indices currently used to rank projects. We discuss the economic value of information and of real options arising in drug development and present decision analysis as an ideal framework for the implementation of real options valuation.

  10. A real-life example of choosing an inherently safer process option.

    PubMed

    Study, Karen

    2007-04-11

    While choosing an inherently safer alternative may seem straightforward, sometimes what seems to be the most obvious alternative may not provide the best risk reduction. The process designer must maintain a broad perspective to be able to recognize all potential hazards when evaluating design options. All aspects of operation such as start-up, shut-down, utility failure, as well as normal operation should be considered. Choosing the inherently safer option is best accomplished early in the option selection phase of a project; however, recycle back to the option selection phase may be needed if an option is not thoroughly evaluated early in the process. In this paper, a project to supply ammonia to a catalytic reactor will be reviewed. During the course of the project, an "inherently safer" alternative was selected and later discarded due to issues uncovered during the detail design phase. The final option chosen will be compared to (1) the original design and (2) the initial "inherently safer" alternative. The final option was inherently safer than both the original design and the initial "inherently safer" alternative even though the design team initially believed that it would not be.

  11. Factorials of real negative and imaginary numbers - A new perspective.

    PubMed

    Thukral, Ashwani K

    2014-01-01

    Presently, factorials of real negative numbers and imaginary numbers, except for zero and negative integers are interpolated using the Euler's gamma function. In the present paper, the concept of factorials has been generalised as applicable to real and imaginary numbers, and multifactorials. New functions based on Euler's factorial function have been proposed for the factorials of real negative and imaginary numbers. As per the present concept, the factorials of real negative numbers, are complex numbers. The factorials of real negative integers have their imaginary part equal to zero, thus are real numbers. Similarly, the factorials of imaginary numbers are complex numbers. The moduli of the complex factorials of real negative numbers, and imaginary numbers are equal to their respective real positive number factorials. Fractional factorials and multifactorials have been defined in a new perspective. The proposed concept has also been extended to Euler's gamma function for real negative numbers and imaginary numbers, and beta function.

  12. Incorporating Asymmetric Dependency Patterns in the Evaluation of IS/IT projects Using Real Option Analysis

    ERIC Educational Resources Information Center

    Burke, John C.

    2012-01-01

    The objective of my dissertation is to create a general approach to evaluating IS/IT projects using Real Option Analysis (ROA). This is an important problem because an IT Project Portfolio (ITPP) can represent hundreds of projects, millions of dollars of investment and hundreds of thousands of employee hours. Therefore, any advance in the…

  13. Incorporating Asymmetric Dependency Patterns in the Evaluation of IS/IT projects Using Real Option Analysis

    ERIC Educational Resources Information Center

    Burke, John C.

    2012-01-01

    The objective of my dissertation is to create a general approach to evaluating IS/IT projects using Real Option Analysis (ROA). This is an important problem because an IT Project Portfolio (ITPP) can represent hundreds of projects, millions of dollars of investment and hundreds of thousands of employee hours. Therefore, any advance in the…

  14. Managerial Real Options Practice in Large System Acquisition: Empirical Descriptions and Comparison with Theory

    DTIC Science & Technology

    2005-05-01

    Principles of Corporate Finance . Irwin-McGraw Hill. New York. Brehmer, B. (1998). Effects of time pressure on fully connected and hierarchical...state of the practice. Journal of Applied Corporate Finance , 14(2), 8-24. Trigeorgis, L. (1993, Autumn). Real options and interactions with

  15. Real options approach to inter-sectoral migration of U.S.farm labor

    Treesearch

    Gulcan Onel; Barry K. Goodwin

    2014-01-01

    The core of the literature on inter-sectoral labor migration is based on net present value models of investment in which individuals are assumed to migrate to take advantage of positive wage differentials. In this article, we argue that a real options approach, taken together with the adjustment costs associated with sectoral relocation, may provide a basis for...

  16. Project coalitions in healthcare construction projects and the application of real options: an exploratory survey.

    PubMed

    van Reedt Dortland, Maartje; Dewulf, Geert; Voordijk, Hans

    2013-01-01

    Exploring the impact of the type of project coalition on types of flexibility by analyzing considered and exercised flexibilities in separated and integrated project coalitions in the design and construction phase and the operations and maintenance phase of a healthcare construction project. Flexibility in healthcare construction projects is increasingly needed in order to deal with growing uncertainties. Until now, little research has been carried out on how and to what extent flexibility is incorporated in different types of project coalitions chosen by healthcare organizations. An exploratory survey was conducted among health organizations in both cure and care. Questions were asked on the position of the real estate department within the organization, the type of project coalitions chosen and the rationale behind this choice, and the extent to which flexibility in terms of a real option was considered and to what extent it had been exercised in a project coalition. Integrated project coalitions pay more attention to flexibility in advance in both the process and the product, but exercise them to a lesser extent than separated project coalitions. The economic feasibility of real options is higher in integrated project coalitions. The study shows that real options thinking is already incorporated in real estate management of healthcare organizations, although more flexibility is considered in advance of the project than is actually realized during and after construction. Built environment, construction, decision making, hospitals, planning.

  17. A Real Options Approach to Quantity and Cost Optimization for Lifetime and Bridge Buys of Parts

    DTIC Science & Technology

    2015-05-01

    NPS2015 A Real Options Approach to Quantity and Cost Optimization for Lifetime and Bridge Buys of Parts Navid Goudarzi, Peter Sandborn...Lifetime and Bridge Buys of Parts 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...assess lifetime or bridge buys. • The optimum part quantity at which to exercise the “stopping the buy early” option and to perform a lifetime buy is

  18. When to Wait for More Evidence? Real Options Analysis in Proton Therapy

    PubMed Central

    Abrams, Keith R.; de Ruysscher, Dirk; Pijls-Johannesma, Madelon; Peters, Hans J.M.; Beutner, Eric; Lambin, Philippe; Joore, Manuela A.

    2011-01-01

    Purpose. Trends suggest that cancer spending growth will accelerate. One method for controlling costs is to examine whether the benefits of new technologies are worth the extra costs. However, especially new and emerging technologies are often more costly, while limited clinical evidence of superiority is available. In that situation it is often unclear whether to adopt the new technology now, with the risk of investing in a suboptimal therapy, or to wait for more evidence, with the risk of withholding patients their optimal treatment. This trade-off is especially difficult when it is costly to reverse the decision to adopt a technology, as is the case for proton therapy. Real options analysis, a technique originating from financial economics, assists in making this trade-off. Methods. We examined whether to adopt proton therapy, as compared to stereotactic body radiotherapy, in the treatment of inoperable stage I non-small cell lung cancer. Three options are available: adopt without further research; adopt and undertake a trial; or delay adoption and undertake a trial. The decision depends on the expected net gain of each option, calculated by subtracting its total costs from its expected benefits. Results. In The Netherlands, adopt and trial was found to be the preferred option, with an optimal sample size of 200 patients. Increase of treatment costs abroad and costs of reversal altered the preferred option. Conclusion. We have shown that real options analysis provides a transparent method of weighing the costs and benefits of adopting and/or further researching new and expensive technologies. PMID:22147003

  19. Combination of real options and game-theoretic approach in investment analysis

    NASA Astrophysics Data System (ADS)

    Arasteh, Abdollah

    2016-02-01

    Investments in technology create a large amount of capital investments by major companies. Assessing such investment projects is identified as critical to the efficient assignment of resources. Viewing investment projects as real options, this paper expands a method for assessing technology investment decisions in the linkage existence of uncertainty and competition. It combines the game-theoretic models of strategic market interactions with a real options approach. Several key characteristics underlie the model. First, our study shows how investment strategies rely on competitive interactions. Under the force of competition, firms hurry to exercise their options early. The resulting "hurry equilibrium" destroys the option value of waiting and involves violent investment behavior. Second, we get best investment policies and critical investment entrances. This suggests that integrating will be unavoidable in some information product markets. The model creates some new intuitions into the forces that shape market behavior as noticed in the information technology industry. It can be used to specify best investment policies for technology innovations and adoptions, multistage R&D, and investment projects in information technology.

  20. Real world evidence: An Indian perspective

    PubMed Central

    Dang, Amit; Vallish, B. N.

    2016-01-01

    Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real world data (RWD) to generate insight, foresight, and explorative findings on diseases, products, and patient populations. There are varied sources of RWD such as administrative data, large pragmatic trials, registries, electronic health records, and health surveys. RWE approaches are increasingly becoming the normal practice in developed countries to bring a product to the healthcare market and to ensure its significance in clinical practice. The Indian healthcare sector is growing at a brisk pace and is grasping up with the principles of health economics and outcome research, thereby exhibiting the value of real-world insights in healthcare decision. India has taken a step toward RWE by developing a framework to assist health care providers in harmonizing RWD for economic, clinical, and humanistic outcome. PMID:27843789

  1. Real world evidence: An Indian perspective.

    PubMed

    Dang, Amit; Vallish, B N

    2016-01-01

    Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real world data (RWD) to generate insight, foresight, and explorative findings on diseases, products, and patient populations. There are varied sources of RWD such as administrative data, large pragmatic trials, registries, electronic health records, and health surveys. RWE approaches are increasingly becoming the normal practice in developed countries to bring a product to the healthcare market and to ensure its significance in clinical practice. The Indian healthcare sector is growing at a brisk pace and is grasping up with the principles of health economics and outcome research, thereby exhibiting the value of real-world insights in healthcare decision. India has taken a step toward RWE by developing a framework to assist health care providers in harmonizing RWD for economic, clinical, and humanistic outcome.

  2. RealGasBrine v1.0 option of TOUGH+ v1.5

    SciTech Connect

    Moridis, George

    2015-02-27

    RealGasBrine v1.0 is a numerical code that for the simulation of the behavior of gas-bearing porous and/fractured geologic media. It is an option of TOUGH+ v1.5 [Moridis, 2014], a successor to the TOUGH2 [Pruess et al., 1999; 2012] family of codes for multi-component, multiphase ?uid and heat ?ow developed at the Lawrence Berkeley National Laboratory. RealGasBrine v1.0 needs the TOUGH+ v1.5 core code in order to compile and execute. It is written in standard FORTRAN 95/2003, and can be run on any computational platform (workstation, PC, Macintosh) for which such compilers are available. RealGasBrine v1.0 describes the non-isothermal two- (for pure water) or three-phase (for brine) flow of an aqueous phase and a real gas mixture in a gas-bearing medium, with a particular focus in ultra-tight (such as tight-sand and shale gas) systems. Up to 12 individual real gases can be tracked, and salt can precipitate as solid halite. The capabilities of the code include coupled flow and thermal effects, real gas behavior, Darcy and non-Darcy flow, several isotherm options of gas sorption onto the grains of the porous media, complex fracture descriptions, gas solubility into water, and geomechanical effects on flow properties. RealGasBrine v1.0 allows the study of flow and transport of fluids and heat over a wide range of time frames and spatial scales not only in gas reservoirs, but also in any problem involving the flow of gases in geologic media, including the geologic storage of greenhouse gas mixtures, the behavior of geothermal reservoirs with multi-component condensable (H2O and CO2) and non-condensable gas mixtures, the transport of water and released H2 in nuclear waste storage applications, etc.

  3. Real Option in Capital Budgeting for SMEs: Insight from Steel Company

    NASA Astrophysics Data System (ADS)

    Muharam, F. M.; Tarrazon, M. A.

    2017-06-01

    Complex components of investment projects can only be analysed accurately if flexibility and comprehensive consideration of uncertainty are incorporated into valuation. Discounted cash flow (DCF) analysis has failed to cope with strategic future alternatives that affect the right value of investment projects. Real option valuation (ROV) proves to be the right tool for this purpose since it enables to calculate the enlarged or strategic Net Present Value (ENPV). This study attempts to provide an insight of the usage of ROV in capital budgeting and investment decision-making processes of SMEs. Exploring into the first stage processing of steel industry, analysis of alternatives to cancel, to expand, to defer or to abandon is performed. Completed with multiple options interaction and a sensitivity analysis, our findings prove that the application of ROV is beneficial for complex investment projects independently from the size of the company and particularly suitable in scenarios with scarce resources. The application of Real Option Valuation (ROV) is plausible and beneficial for SMEs to be incorporated in the strategic decision making process.

  4. A real options approach to biotechnology investment policy-the case of developing a Campylobacter vaccine to poultry.

    PubMed

    Lund, Mogens; Jensen, Jørgen Dejgård

    2016-06-01

    The aim of the article is to identify and analyse public-private incentives for the development and marketing of new animal vaccines within a real options methodological framework, and to investigate how real options methodology can be utilized to support economic incentives for vaccine development in a cost-effective way. The development of a vaccine against Campylobacter jejuni in poultry is applied as a case study. Employing the real options methodology, the net present value of the vaccine R&D project becomes larger than a purely probabilistic expected present value throughout the different stages of the project - and the net present value becomes larger, when more types of real options are taken into consideration. The insight from the real options analysis reveals opportunities for new policies to promote the development of animal vaccines. One such approach might be to develop schemes combining stage-by-stage optimized subsidies in the individual development stages, with proper account taken of investors'/developers' economic incentives to proceed, sell or cancel the project in the respective stages. Another way of using the real options approach to support the development of desirable animal vaccines could be to issue put options for the vaccine candidate, enabling vaccine developers to hedge against the economic risk from market volatility. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Nuclear Terrorism - Dimensions, Options, and Perspectives in Moldova

    NASA Astrophysics Data System (ADS)

    Vaseashta, Ashok; Susmann, P.; Braman, Eric W.; Enaki, Nicolae A.

    Securing nuclear materials, controlling contraband and preventing proliferation is an international priority to resolve using technology, diplomacy, strategic alliances, and if necessary, targeted military exercises. Nuclear security consists of complementary programs involving international legal and regulatory structure, intelligence and law enforcement agencies, border and customs forces, point and stand-off radiation detectors, personal protection equipment, preparedness for emergency and disaster, and consequence management teams. The strategic goal of UNSCR 1540 and the GICNT is to prevent nuclear materials from finding their way into the hands of our adversaries. This multi-jurisdictional and multi-agency effort demands tremendous coordination, technology assessment, policy development and guidance from several sectors. The overall goal envisions creating a secured environment that controls and protects nuclear materials while maintaining the free flow of commerce and individual liberty on international basis. Integral to such efforts are technologies to sense/detect nuclear material, provide advance information of nuclear smuggling routes, and other advanced means to control nuclear contraband and prevent proliferation. We provide an overview of GICNT and several initiatives supporting such efforts. An overview is provided of technological advances in support of point and stand-off detection and receiving advance information of nuclear material movement from perspectives of the Republic of Moldova.

  6. Progressive multifocal leukoencephalopathy: current treatment options and future perspectives

    PubMed Central

    Pavlovic, Dejan; Patera, Andriani C.; Nyberg, Fredrik; Gerber, Marianne; Liu, Maggie

    2015-01-01

    Progressive multifocal leukoencephalopathy (PML) is a rare but debilitating and frequently fatal viral disease of the central nervous system, primarily affecting individuals with chronically and severely suppressed immune systems. The disease was relatively obscure until the outbreak of HIV/AIDS, when it presented as one of the more frequent opportunistic infections in this immune deficiency syndrome. It attracted additional attention from the medical and scientific community following the discovery of significant PML risk associated with natalizumab, a monoclonal antibody used for treatment of relapsing–remitting multiple sclerosis. This was followed by association of PML with other immunosuppressive or immunomodulating drugs. PML is currently untreatable disease with poor outcomes, so it is a significant concern when developing new immunotherapies. Current prophylaxis and treatment of PML are focused on immune reconstitution, restoration of immune responses to JC virus infection, and eventual suppression of immune reconstitution inflammatory syndrome. This approach was successful in reducing the incidence of PML and improved survival of PML patients with HIV infection. However, the outcome for the majority of PML patients, regardless of their medical history, is still relatively poor. There is a high unmet need for both prophylaxis and treatment of PML. The aim of this review is to discuss potential drug candidates for prophylaxis and treatment of PML with a critical review of previously conducted and completed PML treatment studies as well as to provide perspectives for future therapies. PMID:26600871

  7. Future perspectives on space exploration and options for Europe

    NASA Astrophysics Data System (ADS)

    Peter, N.

    2009-04-01

    decades to come (demography, economy, environment, energy etc.) and the development of future potential partners to derive the best options for leading and anticipate rather than following and enduring change.

  8. Real Options in Military System Acquisition: The Case Study of Technology Development for the Javelin Anti-Tank Weapon System

    DTIC Science & Technology

    2013-08-22

    systems engineering from the University of Florida in 1996. She was commissioned an officer in the United States Air Force in 1984...píìÇó= Real Options in Military System Acquisition: The Case Study of Technology Development for the Javelin Anti-Tank Weapon System 22 August 2013...Real Options in Military System Acquisition: The Case Study of Technology Development for the Javelin Anti-Tank Weapon System 5a.

  9. A quadranomial real options model for evaluation of emissions trading and technology

    NASA Astrophysics Data System (ADS)

    Sarkis, Joseph; Tamarkin, Maurry

    2005-11-01

    Green house gas (GHG) emissions have been tied to global climate change. One popular policy instrument that seems to have gained credibility with explicit mention of its application in the Kyoto Protocol is the use of permit trading and cap-and-trade mechanisms. Organizations functioning within this environment will need to manage their resources appropriately to remain competitive. Organizations will either have the opportunity to purchase emissions credits (offsets) from a market trading scheme or seek to reduce their emissions through different measures. Some measures may include investment in new technologies that will reduce their reliance on GHG emitting practices. In many countries, large organizations and institutions generate their own power to operate their facilities. Much of this power is generated (or bought) from GHG producing technology. Specific renewable energy sources such as wind and solar photovoltaic technology may become more feasible alternatives available to a large percentage of these organizations if they are able to take advantage and incorporate the market for GHG emissions trading in their analyses. To help organizations evaluate investment in these renewable energy technologies we introduce a real options based model that will take into consideration uncertainties associated with the technology and those associated with the GHG trading market. The real options analysis will consider both the stochastic (uncertainty) nature of the exercise price of the technology and the stochastic nature of the market trading price of the GHG emissions.

  10. AEGIS and Ship Self-Defense System (SSDS) Platforms: Using KVA Analysis, Risk Simulation and Strategic Real Options to Assess Operational Effectiveness

    DTIC Science & Technology

    2007-04-30

    software development firm specializing in real options, employee stock options , financial valuation, and risk analysis located in Northern...California. He is the creator of the Real Option Super Lattice Solver software, Monte Carlo Risk Simulator software, and Employee Stock Options Valuation...software at the firm. The Employee Stock Options Valuation software was used by the Financial Accounting Standards Board (FASB) to develop their example

  11. Placing the power of real options analysis into the hands of natural resource managers - taking the next step.

    PubMed

    Nelson, Rohan; Howden, Mark; Hayman, Peter

    2013-07-30

    This paper explores heuristic methods with potential to place the analytical power of real options analysis into the hands of natural resource managers. The complexity of real options analysis has led to patchy or ephemeral adoption even by corporate managers familiar with the financial-market origins of valuation methods. Intuitively accessible methods for estimating the value of real options have begun to evolve, but their evaluation has mostly been limited to researcher-driven applications. In this paper we work closely with Bush Heritage Australia to evaluate the potential of real options analysis to support the intuitive judgement of conservation estate managers in covenanting land with uncertain future conservation value due to climate change. The results show that modified decision trees have potential to estimate the option value of covenanting individual properties while time and ongoing research resolves their future conservation value. Complementing this, Luehrman's option space has potential to assist managers with limited budgets to increase the portfolio value of multiple properties with different conservation attributes.

  12. Water resources planning under climate change: Assessing the robustness of real options for the Blue Nile

    NASA Astrophysics Data System (ADS)

    Jeuland, Marc; Whittington, Dale

    2014-03-01

    This article presents a methodology for planning new water resources infrastructure investments and operating strategies in a world of climate change uncertainty. It combines a real options (e.g., options to defer, expand, contract, abandon, switch use, or otherwise alter a capital investment) approach with principles drawn from robust decision-making (RDM). RDM comprises a class of methods that are used to identify investment strategies that perform relatively well, compared to the alternatives, across a wide range of plausible future scenarios. Our proposed framework relies on a simulation model that includes linkages between climate change and system hydrology, combined with sensitivity analyses that explore how economic outcomes of investments in new dams vary with forecasts of changing runoff and other uncertainties. To demonstrate the framework, we consider the case of new multipurpose dams along the Blue Nile in Ethiopia. We model flexibility in design and operating decisions—the selection, sizing, and sequencing of new dams, and reservoir operating rules. Results show that there is no single investment plan that performs best across a range of plausible future runoff conditions. The decision-analytic framework is then used to identify dam configurations that are both robust to poor outcomes and sufficiently flexible to capture high upside benefits if favorable future climate and hydrological conditions should arise. The approach could be extended to explore design and operating features of development and adaptation projects other than dams.

  13. A novel method to value real options in health care: the case of a multicohort human papillomavirus vaccination strategy.

    PubMed

    Favato, Giampiero; Baio, Gianluca; Capone, Alessandro; Marcellusi, Andrea; Saverio Mennini, Francesco

    2013-07-01

    A large number of economic evaluations have already confirmed the cost-effectiveness of different human papillomavirus (HPV) vaccination strategies. Standard analyses might not capture the full economic value of novel vaccination programs because the cost-effectiveness paradigm fails to take into account the value of active management. Management decisions can be seen as real options, a term used to refer to the application of option pricing theory to the valuation of investments in nonfinancial assets in which much of the value is attributable to flexibility and learning over time. The aim of this article was to discuss the potential advantages shown by using the payoff method in the valuation of the cost-effectiveness of competing HPV immunization programs. This was the first study, to the best of our knowledge, to use the payoff method to determine the real option values of 4 different HPV vaccination strategies targeting female subjects aged 12, 15, 18, and 25 years. The payoff method derives the real option value from the triangular payoff distribution of the project's net present value, which is treated as a triangular fuzzy number. To inform the real option model, cost-effectiveness data were derived from an empirically calibrated Bayesian model designed to assess the cost-effectiveness of a multicohort HPV vaccination strategy in the context of the current cervical cancer screening program in Italy. A net health benefit approach was used to calculate the expected fuzzy net present value for each of the 4 vaccination strategies evaluated. Costs per quality-adjusted life-year gained seemed to be related to the number of cohorts targeted: a single cohort of girls aged 12 years (€10,955 [95% CI, -1,021 to 28,212]) revealed the lowest cost among the 4 alternative strategies evaluated. The real option valuation challenged the cost-effectiveness dominance of a single cohort of 12-year-old girls. The simultaneous vaccination of 2 cohorts of girls aged 12 and 15

  14. Adaptive Flood Risk Management Under Climate Change Uncertainty Using Real Options and Optimization.

    PubMed

    Woodward, Michelle; Kapelan, Zoran; Gouldby, Ben

    2014-01-01

    It is well recognized that adaptive and flexible flood risk strategies are required to account for future uncertainties. Development of such strategies is, however, a challenge. Climate change alone is a significant complication, but, in addition, complexities exist trying to identify the most appropriate set of mitigation measures, or interventions. There are a range of economic and environmental performance measures that require consideration, and the spatial and temporal aspects of evaluating the performance of these is complex. All these elements pose severe difficulties to decisionmakers. This article describes a decision support methodology that has the capability to assess the most appropriate set of interventions to make in a flood system and the opportune time to make these interventions, given the future uncertainties. The flood risk strategies have been explicitly designed to allow for flexible adaptive measures by capturing the concepts of real options and multiobjective optimization to evaluate potential flood risk management opportunities. A state-of-the-art flood risk analysis tool is employed to evaluate the risk associated to each strategy over future points in time and a multiobjective genetic algorithm is utilized to search for the optimal adaptive strategies. The modeling system has been applied to a reach on the Thames Estuary (London, England), and initial results show the inclusion of flexibility is advantageous, while the outputs provide decisionmakers with supplementary knowledge that previously has not been considered.

  15. Using real options to evaluate the flexibility in the deployment of SMR

    SciTech Connect

    Locatelli, G.; Mancini, M.

    2012-07-01

    According to recent estimations the financial gap between Large Reactors (LR) and Small Medium Reactors (SMRs) seems not as huge as the economy of scale would suggest, so the SMRs are going to be important players of the worldwide nuclear renaissance. POLIMIs INCAS model has been developed to compare the investment in SMR with respect to LR. It provides the value of IRR (Internal Rate of Return), NPV (Net Present Value), LUEC (Levelized Unitary Electricity Cost), up-front investment, etc. The aim of this research is to integrate the actual INCAS model, based on discounted cash flows, with the real option theory to measure flexibility of the investor to expand, defer or abandon a nuclear project, under future uncertainties. The work compares the investment in a large nuclear power plant with a series of smaller, modular nuclear power plants on the same site. As a consequence it compares the benefits of the large power plant, coming from the economy of scale, to the benefit of the modular project (flexibility) concluding that managerial flexibility can be measured and used by an investor to face the investment risks. (authors)

  16. A metabolism perspective on alternative urban water servicing options using water mass balance.

    PubMed

    Farooqui, Tauheed A; Renouf, Marguerite A; Kenway, Steven J

    2016-12-01

    Urban areas will need to pursue new water servicing options to ensure local supply security. Decisions about how best to employ them are not straightforward due to multiple considerations and the potential for problem shifting among them. We hypothesise that urban water metabolism evaluation based a water mass balance can help address this, and explore the utility of this perspective and the new insights it provides about water servicing options. Using a water mass balance evaluation framework, which considers direct urban water flows (both 'natural' hydrological and 'anthropogenic' flows), as well as water-related energy, we evaluated how the use of alternative water sources (stormwater/rainwater harvesting, wastewater/greywater recycling) at different scales influences the 'local water metabolism' of a case study urban development. New indicators were devised to represent the water-related 'resource efficiency' and 'hydrological performance' of the urban area. The new insights gained were the extent to which alternative water supplies influence the water efficiency and hydrological performance of the urban area, and the potential energy trade-offs. The novel contribution is the development of new indicators of urban water resource performance that bring together considerations of both the 'anthropogenic' and 'natural' water cycles, and the interactions between them. These are used for the first time to test alternative water servicing scenarios, and to provide a new perspective to complement broader sustainability assessments of urban water. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Real-time vehicle detection and tracking based on perspective and non-perspective space cooperation

    NASA Astrophysics Data System (ADS)

    Arróspide, Jon; Salgado, Luis; Nieto, Marcos; Jaureguizar, Fernando

    2009-02-01

    In recent years advanced driver assistance systems (ADAS) have received increasing interest to confront car accidents. In particular, video processing based vehicle detection methods are emerging as an efficient way to address accident prevention. Many video-based approaches are proposed in the literature for vehicle detection, involving sophisticated and costly computer vision techniques. Most of these methods require ad hoc hardware implementations to attain real-time operation. Alternatively, other approaches perform a domain change --via transforms like FFT, inverse perspective mapping (IPM) or Hough transform-- that simplifies otherwise complex feature detection. In this work, a cooperative strategy between two domains, the original perspective space and the transformed non-perspective space computed trough IPM, is proposed in order to alleviate the processing load in each domain by maximizing the information exchange between the two domains. A system is designed upon this framework that computes the location and dimension of the vehicles in a video sequence. Additionally, the system is made scalable to the complexity imposed by the scenario. As a result, real-time vehicle detection and tracking is accomplished in a general purpose platform. The system has been tested for sequences comprising a wide variety of scenarios, showing robust and accurate performance.

  18. "Real" and Apparent Optionality in Second Language Grammars: Finiteness and Pronouns in Null Operator Structures

    ERIC Educational Resources Information Center

    Parodi, Teresa; Tsimpli, Ianthi-Maria

    2005-01-01

    The existence of optionality in acquisitional data presents a problem to the view that developing grammars do not include more than one grammatical system at any stage. In this article data from Greek and Spanish, on the one hand, and English, on the other, constitute the background for the discussion of the existence of "true" optionality in…

  19. A Real Options Approach to Valuing the Risk Transfer in a Multi-Year Procurement Contract

    DTIC Science & Technology

    2009-10-01

    price over the span of the option life,7 Figure 1 and r is the interest rate of a risk -free bond with the tenor of the option expiry. Note... risk in a firm-fixed- price contract. The government also provides interest -free financing that can greatly reduce the amount of capital a contractor...with the fixed- price contract. The government does not expect contractors to accept high technical risk projects using a fixed- price contract.

  20. Game Theoretic Real Option Approach of the Procurement of Department of Defense: Competition or Collaboration

    DTIC Science & Technology

    2011-04-30

    Intelligence Base? is being proposed to approach intelligence and game options in a holistic way for the strategy and the investments. 15. SUBJECT TERMS 16...theoretical, must point to some termination in action; academics have a responsibility to make their work intelligible to practitioners. Thus we continue to... Intelligence Base” is being proposed to approach intelligence and game options in a holistic way for the strategy and the investments. Introduction The

  1. What Motivates Pre-Service Teachers to Become Teachers and Their Perspectives of English Teaching as a Career Option

    ERIC Educational Resources Information Center

    Tustiawati, I. A. Mela

    2017-01-01

    Teaching motivation issues are well-researched in several countries. However, these issues have been rarely investigated in the Indonesian context. This study investigated motivational factors that influence pre-service teachers to enter English teacher training and their perspectives of English teaching as a career option. It comprised a survey…

  2. Real Options Valuation of U.S. Federal Renewable Energy Research,Development, Demonstration, and Deployment

    SciTech Connect

    Siddiqui, Afzal S.; Marnay, Chris; Wiser, Ryan H.

    2005-03-01

    Benefits analysis of US Federal government funded research, development, demonstration, and deployment (RD3) programs for renewable energy (RE) technology improvement typically employs a deterministic forecast of the cost and performance of renewable and nonrenewable fuels. The benefits estimate for a program derives from the difference between two forecasts, with and without the RD3 in place. The deficiencies of the current approach are threefold: (1) it does not consider uncertainty in the cost of non-renewable energy (NRE), and the option or insurance value of deploying RE if and when NRE costs rise; (2) it does not consider the ability of the RD3 manager to adjust the RD3 effort to suit the evolving state of the world, and the option value of this flexibility; and (3) it does not consider the underlying technical risk associated with RD3, and the impact of that risk on the programs optimal level of RD3 effort. In this paper, a rudimentary approach to determining the option value of publicly funded RE RD3 is developed. The approach seeks to tackle the first deficiency noted above by providing an estimate of the options benefit of an RE RD3 program in a future with uncertain NRE costs.While limited by severe assumptions, a computable lattice of options values reveals the economic intuition underlying the decision-making process. An illustrative example indicates how options expose both the insurance and timing values inherent in a simplified RE RD3 program that coarsely approximates the aggregation of current Federal RE RD3.This paper also discusses the severe limitations of this initial approach, and identifies needed model improvements before the approach can adequately respond to the RE RD3 analysis challenge.

  3. The impact of real options on willingness to pay for mortality risk reductions.

    PubMed

    Krüger, Niclas A; Svensson, Mikael

    2009-05-01

    Public investments are dynamic in nature, and decision making must account for the uncertainty, irreversibility and potential for future learning. In this paper we adapt the theory for investment under uncertainty for a public referendum setting and perform the first empirical test to show that estimates of the value of a statistical life (VSL) from stated preference surveys are highly dependent on the inclusion of the option value. Our results indicate an option value of a major economic magnitude. This implies that previously reported VSL estimates, used in societal benefit-cost analysis of health investments, are exaggerated.

  4. ARC-VM: An architecture real options complexity-based valuation methodology for military systems-of-systems acquisitions

    NASA Astrophysics Data System (ADS)

    Domercant, Jean Charles

    The combination of today's national security environment and mandated acquisition policies makes it necessary for military systems to interoperate with each other to greater degrees. This growing interdependency results in complex Systems-of-Systems (SoS) that only continue to grow in complexity to meet evolving capability needs. Thus, timely and affordable acquisition becomes more difficult, especially in the face of mounting budgetary pressures. To counter this, architecting principles must be applied to SoS design. The research objective is to develop an Architecture Real Options Complexity-Based Valuation Methodology (ARC-VM) suitable for acquisition-level decision making, where there is a stated desire for more informed tradeoffs between cost, schedule, and performance during the early phases of design. First, a framework is introduced to measure architecture complexity as it directly relates to military SoS. Development of the framework draws upon a diverse set of disciplines, including Complexity Science, software architecting, measurement theory, and utility theory. Next, a Real Options based valuation strategy is developed using techniques established for financial stock options that have recently been adapted for use in business and engineering decisions. The derived complexity measure provides architects with an objective measure of complexity that focuses on relevant complex system attributes. These attributes are related to the organization and distribution of SoS functionality and the sharing and processing of resources. The use of Real Options provides the necessary conceptual and visual framework to quantifiably and traceably combine measured architecture complexity, time-valued performance levels, as well as programmatic risks and uncertainties. An example suppression of enemy air defenses (SEAD) capability demonstrates the development and usefulness of the resulting architecture complexity & Real Options based valuation methodology. Different

  5. Reducing risk through real options in systems design: the case of architecting a maritime domain protection system.

    PubMed

    Buurman, Joost; Zhang, Stephen; Babovic, Vladan

    2009-03-01

    Complex engineering systems are usually designed to last for many years. Such systems will face many uncertainties in the future. Hence the design and deployment of these systems should not be based on a single scenario, but should incorporate flexibility. Flexibility can be incorporated in system architectures in the form of options that can be exercised in the future when new information is available. Incorporating flexibility comes, however, at a cost. To evaluate if this cost is worth the investment a real options analysis can be carried out. This approach is demonstrated through analysis of a case study of a previously developed static system-of-systems for maritime domain protection in the Straits of Malacca. This article presents a framework for dynamic strategic planning of engineering systems using real options analysis and demonstrates that flexibility adds considerable value over a static design. In addition to this it is shown that Monte Carlo analysis and genetic algorithms can be successfully combined to find solutions in a case with a very large number of possible futures and system designs.

  6. Preeclampsia – Aetiology, Current Diagnostics and Clinical Management, New Therapy Options and Future Perspectives

    PubMed Central

    Tallarek, A.-C.; Huppertz, B.; Stepan, H.

    2012-01-01

    Preeclampsia is a multisystem disease for which the exact causes have not yet been sufficiently clarified. However, in the past few years it has become clear that a placental imbalance between angiogenic and anti-angiogenic proteins is the decisive pathogenetic factor for the occurrence of preeclampsia. With the possibility to measure these angiogenic factors (sFlt-1/PlGF ratio) in maternal blood full new diagnostic possibilities have been opened that enable the certain diagnosis or exclusion of the diseases as well as a short-term prognosis to be made. In secondary prevention the current data situation for ASA confirms a moderate but measurable utility. The management concept depends on gestational age. In the case of early clinical manifestations (< 34th week of pregnancy) the clinical management in a perinatal centre remains unchanged with foeto-maternal monitoring and induction of pulmonary maturation, symptomatic therapy under careful blood pressure lowering and determination of the optimal delivery time. A balance must be made here between foetal immaturity and maternal risks upon prolongations. The pathomechanism of anti-angiogenic overload with sFlt-1 provides a starting point for first therapeutic interventions. The present article gives an overview of current diagnostic options and presents possible future therapeutic perspectives for discussion. PMID:26640284

  7. Vogt-Koyanagi-Harada syndrome: Perspectives for immunogenetics, multimodal imaging, and therapeutic options.

    PubMed

    Silpa-Archa, Sukhum; Silpa-Archa, Narumol; Preble, Janine M; Foster, C Stephen

    2016-08-01

    Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inflammation of the choroidal layer. This phenomenon usually leads to diffuse inflammatory conditions throughout most parts of eye before ocular complications ensue. The diagnosis is achieved mainly by clinical features according to the revised diagnostic criteria of VKH published in 2001, without confirmatory serologic tests as a requirement. However, ancillary tests, especially multimodal imaging, can reliably provide supportive evidence for the diagnosis of early cases, atypical presentations, and evaluation of management. Prompt treatment with systemic corticosteroids and early non-steroidal immunosuppressive drug therapy can lessen visually threatening ocular complications and bring about good visual recovery. Close monitoring warrants visual stabilization from disease recurrence and ocular complications. This article review aims not only to update comprehensive knowledge regarding VKH but also to emphasize three major perspectives of VKH: immunogenetics as the major pathogenesis of the disease, multimodal imaging, and therapeutic options. The role of anti-vascular endothelial growth factor therapy and drug-induced VKH is also provided. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Early Treatment in HCV: Is it a Cost-Utility Option from the Italian Perspective?

    PubMed

    Marcellusi, Andrea; Viti, Raffaella; Damele, Francesco; Cammà, Calogero; Taliani, Gloria; Mennini, Francesco Saverio

    2016-08-01

    In Italy, the Italian Pharmaceutical Agency (AIFA) criteria used F3-F4 fibrosis stages as the threshold to prioritise the treatment with interferon (IFN)-free regimens, while in genotype 1 chronic hepatitis C (G1 CHC) patients with fibrosis of liver stage 2, an approach with pegylated interferon (PEG-IFN)-based triple therapy with simeprevir was suggested. The key clinical question is whether, in an era of financial constraints, the application of a universal IFN-free strategy in naïve G1 CHC patients is feasible within a short time horizon. The aim of this study is to perform an economic analysis to estimate the cost-utility of the early innovative therapy in Italy for managing hepatitis C virus (HCV)-infected patients. The incremental cost-utility analysis was carried out to quantify the benefits of the early treatment approach in HCV subjects. A Markov simulation model including direct and indirect costs and health outcomes was developed from an Italian National Healthcare Service and societal perspective. A total of 5000 Monte Carlo simulations were performed on two distinct scenarios: standard of care (SoC) which includes 14,000 genotype 1 patients in Italy treated with innovative interferon-free regimens in the fibrosis of liver stages 3 and 4 (F3-F4) versus early-treatment scenario (ETS) where 2000 patients were additionally treated with simeprevir plus PEG-IFN and ribavirin in the fibrosis stage 2 (F2) (based on Italian Medicines Agency AIFA reimbursement criteria). A systematic literature review was carried out to identify epidemiological and economic data, which were subsequently used to inform the model. Furthermore, a one-way probabilistic sensitivity was performed to measure the relationship between the main parameters of the model and the cost-utility results. The model shows that, in terms of incremental cost-effectiveness ratio (ICER) per quality adjusted life year (QALY) gained, ETS appeared to be the most cost-utility option compared with both

  9. AIR EMISSIONS FROM RESIDENTIAL HEATING: THE WOOD HEATING OPTION PUT INTO ENVIRONMENTAL PERSPECTIVE

    EPA Science Inventory

    The paper compares the national scale (rather than local) air quality impacts of the various residential space heating options. Specifically, it compares the relative contribution of the space heating options to fine particulate emissions, greenhouse gas emissions, and acid preci...

  10. AIR EMISSIONS FROM RESIDENTIAL HEATING: THE WOOD HEATING OPTION PUT INTO ENVIRONMENTAL PERSPECTIVE

    EPA Science Inventory

    The paper compares the national scale (rather than local) air quality impacts of the various residential space heating options. Specifically, it compares the relative contribution of the space heating options to fine particulate emissions, greenhouse gas emissions, and acid preci...

  11. Age Differences in Consumer Decision Making under Option Framing: From the Motivation Perspective.

    PubMed

    Peng, Huamao; Xia, Shiyong; Ruan, Fanglin; Pu, Bingyan

    2016-01-01

    Option framing effect is the phenomena that participants often accept more options when they are asked to delete undesired options from a full model (subtractive framing) than they do when they are instructed to add desired options to a base model (additive framing). Whether the same effect exists in different age groups is less well known. To explore the roles of age and purchase motivations on the option framing effect for automobiles purchases, this study adopted a 3 (age group: younger, middle-aged, vs. older) × 2 (option framing: additive vs. subtractive) × 2 (focus condition: information vs. emotion) mixed design. To manipulate purchase motivations, participants in the three age groups were instructed to focus on the ratio of utility and price of options (information-focus) or the extent of pleasure induced by the options (emotion-focus) when they made purchase decisions in two framing conditions. The results revealed similar option framing effect across all age groups in the information-focus condition regarding the total price paid for accepted options. In contrast, the framing effect was not found in the emotion-focus condition. In addition, older adults accepted more options and an overall higher price than younger and middle-aged adults in both focus conditions. This difference was more obvious in the emotion-focus condition than in the information-focus condition. Moreover, both the number of accepted options and the total accepted price of the younger group in the information-focus condition were higher than those in the emotion-focus condition, whereas the older and middle-aged groups accepted same number of options and price between two focus conditions. These results imply that purchase motivation is a moderator of the option framing effect and age characteristics linked with motivations must be considered in sales.

  12. Age Differences in Consumer Decision Making under Option Framing: From the Motivation Perspective

    PubMed Central

    Peng, Huamao; Xia, Shiyong; Ruan, Fanglin; Pu, Bingyan

    2016-01-01

    Option framing effect is the phenomena that participants often accept more options when they are asked to delete undesired options from a full model (subtractive framing) than they do when they are instructed to add desired options to a base model (additive framing). Whether the same effect exists in different age groups is less well known. To explore the roles of age and purchase motivations on the option framing effect for automobiles purchases, this study adopted a 3 (age group: younger, middle-aged, vs. older) × 2 (option framing: additive vs. subtractive) × 2 (focus condition: information vs. emotion) mixed design. To manipulate purchase motivations, participants in the three age groups were instructed to focus on the ratio of utility and price of options (information-focus) or the extent of pleasure induced by the options (emotion-focus) when they made purchase decisions in two framing conditions. The results revealed similar option framing effect across all age groups in the information-focus condition regarding the total price paid for accepted options. In contrast, the framing effect was not found in the emotion-focus condition. In addition, older adults accepted more options and an overall higher price than younger and middle-aged adults in both focus conditions. This difference was more obvious in the emotion-focus condition than in the information-focus condition. Moreover, both the number of accepted options and the total accepted price of the younger group in the information-focus condition were higher than those in the emotion-focus condition, whereas the older and middle-aged groups accepted same number of options and price between two focus conditions. These results imply that purchase motivation is a moderator of the option framing effect and age characteristics linked with motivations must be considered in sales. PMID:27872603

  13. The RealGas and RealGasH2O options of the TOUGH+ code for the simulation of coupled fluid and heat flow in tight/shale gas systems

    EPA Science Inventory

    We developed two new EOS additions to the TOUGH+ family of codes, the RealGasH2O and RealGas. The RealGasH2O EOS option describes the non-isothermal two-phase flow of water and a real gas mixture in gas reservoirs, with a particular focus in ultra-tight (such as tight-sand and sh...

  14. The RealGas and RealGasH2O options of the TOUGH+ code for the simulation of coupled fluid and heat flow in tight/shale gas systems

    EPA Science Inventory

    We developed two new EOS additions to the TOUGH+ family of codes, the RealGasH2O and RealGas. The RealGasH2O EOS option describes the non-isothermal two-phase flow of water and a real gas mixture in gas reservoirs, with a particular focus in ultra-tight (such as tight-sand and sh...

  15. Are white-rot fungi a real biotechnological option for the improvement of environmental health?

    PubMed

    Tortella, G; Durán, N; Rubilar, O; Parada, M; Diez, M C

    2015-06-01

    The use of white-rot fungi as a biotechnological tool for cleaning the environment of recalcitrant pollutants has been under evaluation for several years. However, it is still not possible to find sufficiently detailed investigations of this subject to conclude that these fungi can decontaminate the environment. In the present review, we have summarized and discussed evidence about the potential of white-rot fungi to degrade such pollutants as polycyclic aromatic hydrocarbons, dyes or antibiotics as an example of the complex structures that these microorganisms can attack. This review also discusses field experiment results and limitations of white-rot fungi trials from contaminated sites. Moreover, the use of catabolic potential of white-rot fungi in biopurification systems (biobeds) is also discussed. The current status and future perspectives of white-rot fungi, as a viable biotechnological alternative for improvement of environmental health are noted.

  16. Supply chain management and economic valuation of real options in the natural gas and liquefied natural gas industry

    NASA Astrophysics Data System (ADS)

    Wang, Mulan Xiaofeng

    My dissertation concentrates on several aspects of supply chain management and economic valuation of real options in the natural gas and liquefied natural gas (LNG) industry, including gas pipeline transportations, ocean LNG shipping logistics, and downstream storage. Chapter 1 briefly introduces the natural gas and LNG industries, and the topics studied in this thesis. Chapter 2 studies how to value U.S. natural gas pipeline network transport contracts as real options. It is common for natural gas shippers to value and manage contracts by simple adaptations of financial spread option formulas that do not fully account for the implications of the capacity limits and the network structure that distinguish these contracts. In contrast, we show that these operational features can be fully captured and integrated with financial considerations in a fairly easy and managerially significant manner by a model that combines linear programming and simulation. We derive pathwise estimators for the so called deltas and structurally characterize them. We interpret them in a novel fashion as discounted expectations, under a specific weighing distribution, of the amounts of natural gas to be procured/marketed when optimally using pipeline capacity. Based on the actual prices of traded natural gas futures and basis swaps, we show that an enhanced version of the common approach employed in practice can significantly underestimate the true value of natural gas pipeline network capacity. Our model also exhibits promising financial (delta) hedging performance. Thus, this model emerges as an easy to use and useful tool that natural gas shippers can employ to support their valuation and delta hedging decisions concerning natural gas pipeline network transport capacity contracts. Moreover, the insights that follow from our data analysis have broader significance and implications in terms of the management of real options beyond our specific application. Motivated by current developments

  17. The Choice to Homeschool: Home Educator Perspectives and School District Options

    ERIC Educational Resources Information Center

    Dahlquist, Kari L.; York-Barr, Jennifer; Hendel, Darwin D.

    2006-01-01

    Schools today are increasingly market driven, and public schools are competing for students with numerous other educational options. Homeschool education continues to grow rapidly as one such option. Minnesota, considered a leader in school choice, has experienced rapid growth in the incidence of home-educated children. Such growth raises…

  18. Evaluation of food waste disposal options by LCC analysis from the perspective of global warming: Jungnang case, South Korea

    SciTech Connect

    Kim, Mi-Hyung; Song, Yul-Eum; Song, Han-Byul; Kim, Jung-Wk; Hwang, Sun-Jin

    2011-09-15

    Highlights: > Various food waste disposal options were evaluated from the perspective of global warming. > Costs of the options were compared by the methodology of life cycle assessment and life cycle cost analysis. > Carbon price and valuable by-products were used for analyzing environmental credits. > The benefit-cost ratio of wet feeding scenario was the highest. - Abstract: The costs associated with eight food waste disposal options, dry feeding, wet feeding, composting, anaerobic digestion, co-digestion with sewage sludge, food waste disposer, incineration, and landfilling, were evaluated in the perspective of global warming and energy and/or resource recovery. An expanded system boundary was employed to compare by-products. Life cycle cost was analyzed through the entire disposal process, which included discharge, separate collection, transportation, treatment, and final disposal stages, all of which were included in the system boundary. Costs and benefits were estimated by an avoided impact. Environmental benefits of each system per 1 tonne of food waste management were estimated using carbon prices resulting from CO{sub 2} reduction by avoided impact, as well as the prices of by-products such as animal feed, compost, and electricity. We found that the cost of landfilling was the lowest, followed by co-digestion. The benefits of wet feeding systems were the highest and landfilling the lowest.

  19. Orality and Literacy--the Real Difference: A Historical Perspective.

    ERIC Educational Resources Information Center

    Cox, Gary N.

    Just as a contemporary professional person maintains copies of wills, real estate records, and court decrees, so did 15th-century B.C. residents of the ancient city of Nuzi. Such documents, then and now, are generally written by legal scribes. The Hittites of the 14th century B.C. maintained detailed manuals concerning the care and feeding of…

  20. Internalizing production externalities: A structural estimation of real options in the upstream oil and gas industry

    NASA Astrophysics Data System (ADS)

    Muehlenbachs, Lucija

    implies that typically wells are left inactive not because of the option to reactivate, but rather because the cost of environmental cleanup is too high. Should there be externalities from idling the wells (such as continued contamination of groundwater) that are not accounted for in the decision, then this behavior may not be socially optimal. The model predicts that a Pigouvian tax on inactive wells would have the added benefit of inciting the reactivation of oil and gas wells, however in the case of oil, a tax would incite more wells to be decommissioned than reactivated.

  1. The Real-Life-Referent as a Standard for News Perspective Bias.

    ERIC Educational Resources Information Center

    Barbatsis, Gretchen S.

    The concept of news perspective bias necessitates the creation of an empirical standard by which to judge that bias. A study defined and tested a real life referent applicable to planned, sustained news events that have identifiable and accessible participants. The study compared the television news coverage of court ordered busing to achieve…

  2. Real world biodiversity-ecosystem functioning: a seafloor perspective.

    PubMed

    Snelgrove, Paul V R; Thrush, Simon F; Wall, Diana H; Norkko, Alf

    2014-07-01

    The effective application of biodiversity-ecosystem function (BEF) research to societal needs amid the Anthropocene represents the next grand challenge for ecology. Biodiversity knowledge that is most meaningful to society must reconcile insights derived from theory with detailed experiments and broad-scale trends. This perspective requires science that addresses high species richness, redundancy, and natural variability, which simplified 'model systems' cannot mimic. Here, we illustrate solutions of biodiversity knowledge to management and societal problems that combine BEF with scaling experiments, analysis of BEF along environmental gradients, and mapping technologies. We primarily draw examples from biophysical interactions in seafloor environments, which cover 70% of the Earth and add significantly to global ecosystem functions and services. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Method for producing three-dimensional real image using radiographic perspective views of an object

    DOEpatents

    Ellingson, William A.; Read, Alvin A.

    1976-02-24

    A sequence of separate radiographs are made by indexing a radiation source along a known path relative to the object under study. Thus, each radiograph contains information from a different perspective. A holographically-recorded image is then made from each radiographic perspective by exact re-tracing of the rays through each radiographic perspective such that the re-tracing duplicates the geometry under which it was originally prepared. The holographically-stored images are simultaneously illuminated with the conjugate of the reference beam used in the original recordings. The result is the generation of a three-dimensional real image of the object such that a light-sensitive device can be moved to view the real image along any desired surface with the optical information in all other surfaces greatly suppressed.

  4. First-perspective spatial alignment effects from real-world exploration.

    PubMed

    Wilson, Paul N; Wilson, Duncan A; Griffiths, Laura; Fox, Sarah

    2007-09-01

    When spatial knowledge is acquired from secondary-learning media, such as text, people sometimes remember a route in alignment with the first perspective or first direction of travel. However, this first-perspective alignment (FPA) effect has been found only under special circumstances from primary real-world exploration. In Experiment 1, recall of an enclosed small-scale, U-shaped route was compared following learning from a verbal description, a video recording, or real-world exploration; an FPA effect was found in all cases. In Experiments 2 and 3, exploration of physically larger real routes led to statistically significant evidence of an FPA effect when the route was enclosed, but not when cues external to the route were available. The data are discussed in relation to current theories of spatial reference frames.

  5. A Real-World Perspective on Molecular Design.

    PubMed

    Kuhn, Bernd; Guba, Wolfgang; Hert, Jérôme; Banner, David; Bissantz, Caterina; Ceccarelli, Simona; Haap, Wolfgang; Körner, Matthias; Kuglstatter, Andreas; Lerner, Christian; Mattei, Patrizio; Neidhart, Werner; Pinard, Emmanuel; Rudolph, Markus G; Schulz-Gasch, Tanja; Woltering, Thomas; Stahl, Martin

    2016-05-12

    We present a series of small molecule drug discovery case studies where computational methods were prospectively employed to impact Roche research projects, with the aim of highlighting those methods that provide real added value. Our brief accounts encompass a broad range of methods and techniques applied to a variety of enzymes and receptors. Most of these are based on judicious application of knowledge about molecular conformations and interactions: filling of lipophilic pockets to gain affinity or selectivity, addition of polar substituents, scaffold hopping, transfer of SAR, conformation analysis, and molecular overlays. A case study of sequence-driven focused screening is presented to illustrate how appropriate preprocessing of information enables effective exploitation of prior knowledge. We conclude that qualitative statements enabling chemists to focus on promising regions of chemical space are often more impactful than quantitative prediction.

  6. [Chemical weapons: antidotes. View about the real means, perspectives].

    PubMed

    Ricordel, I; Meunier, J

    2000-01-01

    Chemical methods remain a credible threat in 1999. The doctrine for their use not only includes the battlefield but also domestic terrorism as was disclosed during the Tokyo metro attempt in 1995. International Treaties have not yet proven their efficacy. The arsenal of chemical weapons has changed little since the second World War but is now dispersed into many high-risk zones throughout the world. There has also been little change in antidotes: therapeutic prevention with pyridostigmine against organo-phosphorus compounds, protective treatment for seizure-induced brain lesions using anticonvulsants in association with oxime for acetylcholinesterase reactivation, and atropine are combined in a three-compartment syringe. Preventive measures against vesicants and other suffocating or toxic intracellular substances (CN, AsH(3), fluorocarbons.) can only be achieved with protective skin covering or protective breathing devices. There is no specific treatment and we often have to use symptomatic medications. Future perspectives include: phosphotriesterases as organo-phosphorus scavengers, huperzine as pretreatment and gacyclidine (GCK 11) which would effectively complete emergency multiple drug therapy against nerve agents. A new two-compartment syringe is now prepared with atropine, avisafone and HI6 or pralidoxine. A gel made of cyclodextrines for external and eventually internal use is under study.

  7. Awareness and perceived fairness of Option B+ in Malawi: A population-level perspective

    PubMed

    Yeatman, Sara; Trinitapoli, Jenny

    2017-03-08

    Policies for rationing antiretroviral therapy (ART) have been subject to on-going ethical debates. Introduced in Malawi in 2011, Option B+ prioritized HIV-positive pregnant women for lifelong ART regardless of the underlying state of their immune system, shifting the logic of allocation away from medical eligibility. Despite the rapid expansion of this policy, we know little about how it has been understood and interpreted by the people it affects. We assessed awareness and perceived fairness of the prioritization system for ART among a population-based sample of young women (n = 1440) and their partners (n = 574) in southern Malawi. We use a card-sort technique to elicit understandings of who gets ART under Option B+ and who should be prioritized, and we compare perceptions to actual ART policy using sequence analysis and optimal matching. We then use ordered logistic regression to identify the factors associated with policy awareness. In 2015, only 30.7% of women and 21.1% of male partners understood how ART was being distributed. There was widespread confusion around whether otherwise healthy HIV-positive pregnant women could access ART under Option B + . Nonetheless, more young adults thought that the fairest policy should prioritize such women than believed the actual policy did. Women who were older, more educated or had recently engaged with the health system through antenatal care or ART had more accurate understandings of Option B + . Among men, policy awareness was lower, and was patterned only by education. Although most respondents were unaware that Option B+ afforded ART access to healthy-pregnant women, Malawians support the prioritization of pregnant women. Countries adopting Option B+ or other new ART policies such as universal test-and-treat should communicate the policies and their rationales to the public - such transparency would be more consistent with a fair and ethical process and could additionally serve to clarify confusion and

  8. Unmet needs of patients with narcolepsy: perspectives on emerging treatment options

    PubMed Central

    Wozniak, Dariusz R; Quinnell, Timothy G

    2015-01-01

    The treatment options currently available for narcolepsy are often unsatisfactory due to suboptimal efficacy, troublesome side effects, development of drug tolerance, and inconvenience. Our understanding of the neurobiology of narcolepsy has greatly improved over the last decade. This knowledge has not yet translated into additional therapeutic options for patients, but progress is being made. Some compounds, such as histaminergic H3 receptor antagonists, may prove useful in symptom control of narcolepsy. The prospect of finding a cure still seems distant, but hypocretin replacement therapy offers some promise. In this narrative review, we describe these developments and others which may yield more effective narcolepsy treatments in the future. PMID:26045680

  9. Option pricing formulas and nonlinear filtering: a Feynman path integral perspective

    NASA Astrophysics Data System (ADS)

    Balaji, Bhashyam

    2013-05-01

    Many areas of engineering and applied science require the solution of certain parabolic partial differential equa­ tions, such as the Fokker-Planck and Kolmogorov equations. The fundamental solution, or the Green's function, for such PDEs can be written in terms of the Feynman path integral (FPI). The partial differential equation arising in the valuing of options is the Kolmogorov backward equation that is referred to as the Black-Scholes equation. The utility of this is demonstrated and numerical examples that illustrate the high accuracy of option price calculation even when using a fairly coarse grid.

  10. A Real Options Method for Estimating the Adoption Potential of Forestry and Agroforestry Systems on Private Lands in the Lower Mississippi Alluvial Valley, USA

    Treesearch

    Gregory E. Frey; D. Evan Mercer; Frederick W. Cubbage; Robert C. Abt

    2010-01-01

    The Lower Mississippi River Alluvial Valley (LMAV), once was the largest forested bottom-land area in the continental United States, but has undergone widespread loss of forest through conversion to farmland. Restoration of forest functions and values has been a key conservation goal in the LMAV since the 1970s. This study utilizes a partial differential real options...

  11. Implementation of a real option in a sustainable supply chain: an empirical study of alkaline battery recycling

    NASA Astrophysics Data System (ADS)

    Cucchiella, Federica; D'Adamo, Idiano; Gastaldi, Massimo; Lenny Koh, S. C.

    2014-06-01

    Green supply chain management (GSCM) has emerged as a key approach for enterprises seeking to become environmentally sustainable. This paper aims to evaluate and describe the advantages of a GSCM approach by analysing practices and performance consequences in the battery recycling sector. It seeks to integrate works in supply chain management (SCM), environmental management, performance management and real option (RO) theory into one framework. In particular, life cycle assessment (LCA) is applied to evaluate the environmental impact of a battery recycling plant project, and life cycle costing (LCC) is applied to evaluate its economic impact. Firms, also understanding the relevance of GSCM, have often avoided applying the green principles because of the elevated costs that such management involved. Such costs could also seem superior to the potential advantages since standard performance measurement systems are internally and business focused; for these reasons, we consider all the possible value deriving also by uncertainty associated to a green project using the RO theory. This work is one of the few and pioneering efforts to investigate GSCM practices in the battery recycling sector.

  12. Mechanisms from models--actual effects from real life: the zero-calorie drink-break option.

    PubMed

    Booth, D A

    1988-01-01

    Animal and human laboratory models show that the suppression of appetite by a modest amount of readily assimilable energy, such as a caloric sweetener, is not likely to last longer than an hour. The transience of their satiating effect constitutes a mechanism whereby the sugars, starch, alcohol and fats in drinks and the snackfoods eaten with them could add to energy intake which is subsequently uncompensated and so contributes to weight gain. Conversely, if those in the habit of consuming such energy-containing drinks and accompaniments avoided such items or replaced them by low-calorie substitutes, this might help in weight reduction and even perhaps in prevention of obesity. The effectiveness of this "zero-calorie drink-break option" can be tested by correlating separately reported real-life eating habits and weight changes across people whose circumstances are similar. The existing field data indicate that the fatter a person is the more likely they are to use the conventional undifferentiated sugar-substitution strategies and also that these usually do not help weight reduction.

  13. An ill-posed problem for the Black-Scholes equation for a profitable forecast of prices of stock options on real market data

    NASA Astrophysics Data System (ADS)

    Klibanov, Michael V.; Kuzhuget, Andrey V.; Golubnichiy, Kirill V.

    2016-01-01

    A new empirical mathematical model for the Black-Scholes equation is proposed to forecast option prices. This model includes new interval for the price of the underlying stock, new initial and new boundary conditions. Conventional notions of maturity time and strike prices are not used. The Black-Scholes equation is solved as a parabolic equation with the reversed time, which is an ill-posed problem. Thus, a regularization method is used to solve it. To verify the validity of our model, real market data for 368 randomly selected liquid options are used. A new trading strategy is proposed. Our results indicates that our method is profitable on those options. Furthermore, it is shown that the performance of two simple extrapolation-based techniques is much worse. We conjecture that our method might lead to significant profits of those financial insitutions which trade large amounts of options. We caution, however, that further studies are necessary to verify this conjecture.

  14. [Allergen-specific immunotherapy for food allergies in childhood. Current options and future perspectives].

    PubMed

    Trendelenburg, Valérie; Blümchen, Katharina

    2016-07-01

    During recent years increasing research has been conducted on casual treatment options for food allergy, with focus on oral immunotherapy (OIT) for hen's egg, cow's milk and peanut allergy. Several studies could show that OIT leads to desensitization or an increase of threshold. However, severe adverse events during this treatment are not uncommon. Whether OIT leads to a sustained, 'robust' development of tolerance in patients has not yet been thoroughly investigated. Besides OIT, some studies on sublingual (SLIT) and epicutaneous immunotherapy (EPIT) were performed, aiming to improve the safety profile. Furthermore, there are some pilot studies investigating a combined treatment of SLIT and OIT or a combined use of anti-IgE treatment or probiotic supplementation with OIT. Further placebo-controlled trials with larger sample size are needed in order to develop standardized protocols before immunotherapy may be used as a therapeutic option for food allergy outside of clinical trials.

  15. Referral and management options for patients with chronic kidney disease: perspectives of patients, generalists and specialists.

    PubMed

    Wilson, Charlotte; Campbell, Stephen M; Luker, Karen A; Caress, Ann-Louise

    2015-06-01

    Chronic Kidney Disease (CKD) is increasing in prevalence and significance as a global public health issue. Appropriate management of CKD stages 3-4 in either generalist or specialist care is essential in order to slow disease progression. As various consulting options between services may be used, it is important to understand how patients and practitioners view these options. To elicit patient and practitioner views and preferences on the acceptability and appropriateness of referral practices and consulting options for CKD stage 3-4. A mixed methods approach involving a semi-structured interview and structured rating exercise administered by telephone. Adult (18+) patients with CKD stage 3-4 were recruited via their General Practitioner (GP). Practitioners were recruited from both general and specialist services. Sixteen patients and twenty-two practitioners participated in the study between July and September, 2011. Both patients and practitioners preferred 'GP with access to a specialist' and least preferred 'Specialist Review'. Computer review and telephone review were acceptable to participants under certain conditions. Practitioners favoured generalist management of patients with CKD 3. Specialists recommended active discharge of patients with stabilised stage 4 back to generalist care. Both generalists and specialists strongly supported sharing patients' medical records via electronic consultation systems. Participants tended to prefer the current model of CKD management. Suggested improvements included; increasing the involvement of patients in referral and discharge decisions; improving the adequacy of information given to specialists on referral and encouraging further use of clinical guidelines in practice. © 2012 Blackwell Publishing Ltd.

  16. Real Time Pricing as a Default or Optional Service for C&ICustomers: A Comparative Analysis of Eight Case Studies

    SciTech Connect

    Barbose, Galen; Goldman, Charles; Bharvirkar, Ranjit; Hopper,Nicole; Ting, Michael; Neenan, Bernie

    2005-08-01

    Demand response (DR) has been broadly recognized to be an integral component of well-functioning electricity markets, although currently underdeveloped in most regions. Among the various initiatives undertaken to remedy this deficiency, public utility commissions (PUC) and utilities have considered implementing dynamic pricing tariffs, such as real-time pricing (RTP), and other retail pricing mechanisms that communicate an incentive for electricity consumers to reduce their usage during periods of high generation supply costs or system reliability contingencies. Efforts to introduce DR into retail electricity markets confront a range of basic policy issues. First, a fundamental issue in any market context is how to organize the process for developing and implementing DR mechanisms in a manner that facilitates productive participation by affected stakeholder groups. Second, in regions with retail choice, policymakers and stakeholders face the threshold question of whether it is appropriate for utilities to offer a range of dynamic pricing tariffs and DR programs, or just ''plain vanilla'' default service. Although positions on this issue may be based primarily on principle, two empirical questions may have some bearing--namely, what level of price response can be expected through the competitive retail market, and whether establishing RTP as the default service is likely to result in an appreciable level of DR? Third, if utilities are to have a direct role in developing DR, what types of retail pricing mechanisms are most appropriate and likely to have the desired policy impact (e.g., RTP, other dynamic pricing options, DR programs, or some combination)? Given a decision to develop utility RTP tariffs, three basic implementation issues require attention. First, should it be a default or optional tariff, and for which customer classes? Second, what types of tariff design is most appropriate, given prevailing policy objectives, wholesale market structure, ratemaking

  17. HIV-positive pregnant and postpartum women's perspectives about Option B+ in Malawi: a qualitative study

    PubMed Central

    Katirayi, Leila; Namadingo, Hazel; Phiri, Mafayo; Bobrow, Emily A; Ahimbisibwe, Allan; Berhan, Aida Yemane; Buono, Nicole; Moland, Karen Marie; Tylleskär, Thorkild

    2016-01-01

    Introduction The implementation of lifelong antiretroviral treatment (ART) for all pregnant women (Option B+) in Malawi has resulted in a significant increase in the number of HIV-positive pregnant women initiating treatment. However, research has highlighted the challenge of retaining newly initiated women in care. This study explores barriers and facilitators that affect a woman's decision to initiate and to adhere to Option B+. Methods A total of 39 in-depth interviews and 16 focus group discussions were conducted. Eligible women were ≥18 years old, living with HIV and either pregnant and receiving antenatal care from a study site or had delivered a child within the last 18 months, breastfed their child and received services at one of the study sites. Eligible women were identified by healthcare workers (HCWs) in the antenatal clinic and ART unit. Focus groups were also conducted with HCWs employed in these departments. Qualitative data were analyzed using Maxqda version 10 (VERBI Software, Berlin, Germany). Results The general perception towards the drug regimen used in Option B+ was positive; women reported fewer side effects and acknowledged the positive benefits of ART. Women felt hopeful about prolonging their life and having an HIV-uninfected baby, yet grappled with the fact that ART is a lifelong commitment. Women and HCWs discussed challenges with the counselling services for prevention of mother-to-child HIV transmission under the new Option B+ guidelines, and many women struggled with initiating ART on the same day as learning their HIV status. Women wanted to discuss their circumstances with their husbands first, receive a CD4 count and obtain an HIV test at another facility to confirm their HIV status. HCWs expressed concern that women might just agree to take the drugs to please them. HCWs also discussed concerns around loss to follow-up and drug resistance. Conclusions Although Option B+ has significantly increased the number of women initiating

  18. Evaluation of food waste disposal options by LCC analysis from the perspective of global warming: Jungnang case, South Korea.

    PubMed

    Kim, Mi-Hyung; Song, Yul-Eum; Song, Han-Byul; Kim, Jung-Wk; Hwang, Sun-Jin

    2011-01-01

    The costs associated with eight food waste disposal options, dry feeding, wet feeding, composting, anaerobic digestion, co-digestion with sewage sludge, food waste disposer, incineration, and landfilling, were evaluated in the perspective of global warming and energy and/or resource recovery. An expanded system boundary was employed to compare by-products. Life cycle cost was analyzed through the entire disposal process, which included discharge, separate collection, transportation, treatment, and final disposal stages, all of which were included in the system boundary. Costs and benefits were estimated by an avoided impact. Environmental benefits of each system per 1 tonne of food waste management were estimated using carbon prices resulting from CO(2) reduction by avoided impact, as well as the prices of by-products such as animal feed, compost, and electricity. We found that the cost of landfilling was the lowest, followed by co-digestion. The benefits of wet feeding systems were the highest and landfilling the lowest.

  19. PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives

    PubMed Central

    Sehouli, J.; Braicu, E. I.; Chekerov, R.

    2016-01-01

    More than simply a promising management option, PARP inhibitors can be regarded as a milestone in the development of personalised treatment of recurrent ovarian carcinoma. Their mechanism of action, known as “synthetic lethality”, is dependent on functional differences of the DNA repair mechanisms of healthy cells and tumour cells; cells that repair DNA damage less efficiently are particularly sensitive to PARP inhibitors. Olaparib, licensed for use this year, is the best-studied PARP inhibitor used for treatment of high-grade serous ovarian carcinoma (HGSC). The efficacy of PARP inhibitors appears to be increased when used in combination with other treatments. PMID:26941449

  20. Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective.

    PubMed

    Sullivan, Denise; Lyons, Mary; Montgomery, Robert; Quinlan-Colwell, Ann

    Challenges with opioids (e.g., adverse events, misuse and abuse with long-term administration) have led to a renewed emphasis on opioid-sparing multimodal management of trauma pain. To assess the extent to which currently available evidence supports the efficacy and safety of various nonopioid analgesics and techniques to manage trauma pain, a literature search of recently published references was performed. Additional citations were included on the basis of authors' knowledge of the literature. Effective options for opioid-sparing analgesics include oral and intravenous (IV) acetaminophen; nonsteroidal anti-inflammatory drugs available via multiple routes; and anticonvulsants, which are especially effective for neuropathic pain associated with trauma. Intravenous routes (e.g., IV acetaminophen, IV ketorolac) may be associated with a faster onset of action than oral routes. Additional adjuvants for the treatment of trauma pain are muscle relaxants and alpha-2 adrenergic agonists. Ketamine and regional techniques play an important role in multimodal therapy but require medical and nursing support. Nonpharmacologic treatments (e.g., cryotherapy, distraction techniques, breathing and relaxation, acupuncture) supplement pharmacologic analgesics and can be safe and easy to implement. In conclusion, opioid-sparing multimodal analgesia addresses concerns associated with high doses of opioids, and many pharmacologic and nonpharmacologic options are available to implement this strategy. Nurses play key roles in comprehensive patient assessment; administration of patient-focused, opioid-sparing, multimodal analgesia in trauma; and monitoring for safety concerns.

  1. Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

    PubMed Central

    Lyons, Mary; Montgomery, Robert; Quinlan-Colwell, Ann

    2016-01-01

    Challenges with opioids (e.g., adverse events, misuse and abuse with long-term administration) have led to a renewed emphasis on opioid-sparing multimodal management of trauma pain. To assess the extent to which currently available evidence supports the efficacy and safety of various nonopioid analgesics and techniques to manage trauma pain, a literature search of recently published references was performed. Additional citations were included on the basis of authors' knowledge of the literature. Effective options for opioid-sparing analgesics include oral and intravenous (IV) acetaminophen; nonsteroidal anti-inflammatory drugs available via multiple routes; and anticonvulsants, which are especially effective for neuropathic pain associated with trauma. Intravenous routes (e.g., IV acetaminophen, IV ketorolac) may be associated with a faster onset of action than oral routes. Additional adjuvants for the treatment of trauma pain are muscle relaxants and alpha-2 adrenergic agonists. Ketamine and regional techniques play an important role in multimodal therapy but require medical and nursing support. Nonpharmacologic treatments (e.g., cryotherapy, distraction techniques, breathing and relaxation, acupuncture) supplement pharmacologic analgesics and can be safe and easy to implement. In conclusion, opioid-sparing multimodal analgesia addresses concerns associated with high doses of opioids, and many pharmacologic and nonpharmacologic options are available to implement this strategy. Nurses play key roles in comprehensive patient assessment; administration of patient-focused, opioid-sparing, multimodal analgesia in trauma; and monitoring for safety concerns. PMID:27828892

  2. Is Entombment an Acceptable Option for Decommissioning? An International Perspective - 13488

    SciTech Connect

    Belencan, Helen; Nys, Vincent; Guskov, Andrey; Francois, Patrice; Watson, Bruce; Ljubenov, Vladan

    2013-07-01

    Selection of a decommissioning strategy is one of the key steps in the preparation for decommissioning of nuclear facilities and other facilities using radioactive material. Approaches being implemented or considered by Member States include immediate dismantling, deferred dismantling and entombment. Other options or slight modifications of these strategies are also possible. Entombment has been identified in the current International Atomic Energy Agency (IAEA) Safety Standards as one of the three basic decommissioning strategies and has been defined as a decommissioning strategy by which radioactive contaminants are encased in a structurally long lived material until radioactivity decays to a level permitting the unrestricted release of the facility, or release with restrictions imposed by the regulatory body. Although all three strategies have been considered, in principle, applicable to all facilities, their application to some facilities may not be appropriate owing to political concerns, safety or environmental requirements, technical considerations, local conditions or financial considerations. The IAEA is currently revising the decommissioning Safety Standards and one of the issues widely discussed has been the applicability of entombment in the context of decommissioning and its general objective to enable removal of regulatory control from the decommissioned facility. The IAEA recently established a consultancy to collect and discuss experience and lessons learned from entombment projects, to identify regulatory requirements and expectations for applying entombment as a decommissioning option strategy, in compliance with the internationally agreed standards. (authors)

  3. Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective.

    PubMed

    Singh, Om Prakash; Singh, Bhawana; Chakravarty, Jaya; Sundar, Shyam

    2016-03-08

    Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality and major disability in the Indian subcontinent. It is most neglected tropical disease, particularly in terms of new drug development for the lack of financial returns. An elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district level. One of the major components in this endeavor is reducing transmission through early case detection followed by complete treatment. Substantial progress has been made during the recent years in the area of VL treatment, and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic areas. However, many challenges remain to be overcome including availability of drugs, cost of treatment (drugs and hospitalization), efficacy, adverse effects, and growing parasite resistance. Therefore, better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial drugs. It is essential that the new treatment options become truly accessible, not simply available in endemic areas so that they may promote healing and save lives. In this review, we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area, and discuss the possible strategies to improve the therapeutic outcome.

  4. Analysis of sampling plan options for tank 16H from the perspective of statistical uncertainty

    SciTech Connect

    Shine, E. P.

    2013-02-28

    This report develops a concentration variability model for Tank 16H in order to compare candidate sampling plans for assessing the concentrations of analytes in the residual material in the annulus and on the floor of the primary vessel. A concentration variability model is used to compare candidate sampling plans based on the expected upper 95% confidence limit (UCL95) for the mean. The result is expressed as a rank order of candidate sampling plans from lowest to highest expected UCL95, with the lowest being the most desirable from an uncertainty perspective.

  5. Management options for children with attention-deficit/hyperactivity disorder: a regional perspective on value.

    PubMed

    Ollendorf, Daniel A; Migliaccio-Walle, Kristen; Colby, Jennifer A; Pearson, Steven D

    2013-05-01

    Use of comparative effectiveness information in local healthcare decisions can be confounded by variations in practice, barriers to access and population demographics. The New England Comparative Effectiveness Public Advisory Council was convened as a public deliberative panel that considers evidence on the comparative clinical effectiveness and comparative value of a variety of therapeutic interventions. The council is tasked with making summary judgments on the evidence and recommendations for applying the evidence in medical and drug coverage policy, as well as initiating educational efforts for patients and clinicians. The New England Comparative Effectiveness Public Advisory Council met in June 2012 to discuss management options for attention-deficit/hyperactivity disorder, guided by a recent comparative effectiveness review from the Agency for Healthcare Research and Quality and supplementary economic analyses conducted by the Institute for Clinical and Economic Review. This article summarizes the deliberations and reflects on lessons learned regarding use of region-specific economic analyses to guide decision-making.

  6. Treatment of triple negative breast cancer (TNBC): current options and future perspectives.

    PubMed

    De Laurentiis, M; Cianniello, D; Caputo, R; Stanzione, B; Arpino, G; Cinieri, S; Lorusso, V; De Placido, S

    2010-11-01

    Breast cancer is not considered anymore a unique disease. Microarray gene expression analysis led to the identification of 4 major breast cancer "intrinsic" subtypes, including hormone receptor (HR)-positive luminal A and B, human epidermal growth receptor 2 (HER2)-positive and basal-like breast cancer (BLBC). These subtypes have distinct phenotypes, molecular profiles, clinical behaviour and response to therapy, with the BLBC carrying the worst outcome. Microarray analysis is not feasible in routine practice and therefore oncologists rely on a simpler immunohistochemical (IHC) classification to identify relevant breast cancer subtypes. Triple negative breast cancer (TNBC) is defined by the absence of oestrogen receptor, progesterone receptor and HER2 expression at IHC analysis. TNBC is strictly related to BLBC and, given the lack of common therapeutic targets, represent a major challenge for breast oncologist. In this review we will summarize the updated knowledge on TNBC, with emphasis on its current treatment and on the new therapeutic options under development.

  7. A European Perspective on Topical Ophthalmic Antibiotics: Current and Evolving Options

    PubMed Central

    Bremond-Gignac, D.; Chiambaretta, F.; Milazzo, S.

    2011-01-01

    Background Eye infections can be vision-threatening and must be treated effectively by appropriate and safe use of topical ophthalmic anti-infectives. This review will essentially consider the current and evolving treatment options for the various types of bacterial eye infections. Ocular surface bacterial infections affect subjects of all ages with a high frequency in newborns and children. Methods This article presents a review of the peer-reviewed published scientific literature in order to define the well-established uses of anti-infective eye drops in the field of ocular infections. A comprehensive search of the recent published literature including topical ophthalmic anti-infectives effective in bacterial ocular infections was performed. Clinical studies provide relevant data concerning the characteristics and clinical efficacy of antibacterial eye drops in ocular anterior segment infections or for perioperative prophylaxis. Publications were included to cover the current options of antibacterial eye drops available in Europe. Results Several recent publications identified effective topical ocular antibacterials requiring a reduced dose regimen and a short treatment course. Additional literature reviewed included data on novel perioperative prophylaxis, indications for topical fortified antibiotics and innovative research including the risk of resistance. Conclusions Safe and effective topical antibiotic eye drops for the treatment and prevention of ocular infections must be adapted to the type of bacteria suspected. Usual topical antimicrobials should be replaced by more recent and more effective treatments. The use of highly effective fluoroquinolones should be reserved for the most severe cases to avoid resistance. Short treatment courses, such as azithromycin, can be easily used in children, thereby improving quality of life. PMID:23861622

  8. Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas

    PubMed Central

    De Vita, Alessandro; Mercatali, Laura; Recine, Federica; Pieri, Federica; Riva, Nada; Bongiovanni, Alberto; Liverani, Chiara; Spadazzi, Chiara; Miserocchi, Giacomo; Amadori, Dino; Ibrahim, Toni

    2016-01-01

    Sarcomas are a heterogeneous group of mesenchymal tumors arising from soft tissue or bone, with an uncertain etiology and difficult classification. Soft tissue sarcomas (STSs) account for around 1% of all adult cancers. Till date, more than 50 histologic subtypes have been identified. Adipocyte sarcoma or liposarcoma (LPS) is one of the most common STS subtypes, accounting for 15% of all sarcomas, with an incidence of 24% of all extremity STSs and 45% of all retroperitoneal STSs. The new World Health Organization classification system has divided LPS into four different subgroups: atypical lipomatous tumor/well-differentiated LPS, dedifferentiated LPS, myxoid LPS, and pleomorphic LPS. These lesions can develop at any location and exhibit different aggressive potentials reflecting their morphologic diversity and clinical behavior. Patients affected by LPS should be managed in specialized multidisciplinary cancer centers. Whereas surgical resection is the mainstay of treatment for localized disease, the benefits of adjuvant and neoadjuvant chemotherapy are still unclear. Systemic treatment, particularly chemotherapy, is still limited in metastatic disease. Despite the efforts toward a better understanding of the biology of LPS, the outcome of advanced and metastatic patients remains poor. The advent of targeted therapies may lead to an improvement of treatment options and clinical outcomes. A larger patient enrollment into translational and clinical studies will help increase the knowledge of the biological behavior of LPSs, test new drugs, and introduce new methodological studies, that is, on treatment response. PMID:27785071

  9. Food waste conversion options in Singapore: environmental impacts based on an LCA perspective.

    PubMed

    Khoo, Hsien H; Lim, Teik Z; Tan, Reginald B H

    2010-02-15

    Proper management and recycling of huge volumes of food waste is one of the challenges faced by Singapore. Semakau island - the only offshore landfill of the nation - only accepts inert, inorganic solid waste and therefore a large bulk of food waste is directed to incinerators. A remaining small percent is sent for recycling via anaerobic digestion (AD), followed by composting of the digestate material. This article investigates the environmental performance of four food waste conversion scenarios - based on a life cycle assessment perspective - taking into account air emissions, useful energy from the incinerators and AD process, as well as carbon dioxide mitigation from the compost products derived from the digestate material and a proposed aerobic composting system. The life cycle impact results were generated for global warming, acidification, eutrophication, photochemical oxidation and energy use. The total normalized results showed that a small-scale proposed aerobic composting system is more environmentally favorable than incinerators, but less ideal compared to the AD process. By making full use of the AD's Recycling Phase II process alone, the Singapore Green Plan's 2012 aim to increase the recycling of food waste to 30% can easily be achieved, along with reduced global warming impacts.

  10. Perspectives on biomedical HIV prevention options among women who inject drugs in Kenya.

    PubMed

    Bazzi, Angela Robertson; Yotebieng, Kelly A; Agot, Kawango; Rota, Grace; Syvertsen, Jennifer L

    2017-08-05

    Due to heightened vulnerability to HIV from frequent engagement in sex work and overlapping drug-using and sexual networks, women who inject drugs should be a high priority population for pre-exposure prophylaxis (PrEP) and other biomedical HIV prevention tools. Kenya is one of the first African countries to approve oral PrEP for HIV prevention among "key populations," including people who inject drugs and sex workers. The objective of this study was to explore preferences and perceived challenges to PrEP adoption among women who inject drugs in Kisumu, Kenya. We conducted qualitative interviews with nine HIV-uninfected women who inject drugs to assess their perceptions of biomedical HIV interventions, including oral PrEP, microbicide gels, and intravaginal rings. Despite their high risk and multiple biomedical studies in the region, only two women had ever heard of any of these methods. All women were interested in trying at least one biomedical prevention method, primarily to protect themselves from partners who were believed to have multiple other sexual partners. Although women shared concerns about side effects and product efficacy, they did not perceive drug use as a significant deterrent to adopting or adhering to biomedical prevention methods. Beginning immediately and continuing throughout Kenya's planned PrEP rollout, efforts are urgently needed to include the perspectives of high risk women who use drugs in biomedical HIV prevention research and programing.

  11. Adaptation Options for Land Drainage Systems Towards Sustainable Agriculture and Environment: A Czech Perspective

    NASA Astrophysics Data System (ADS)

    Kulhavý, Zbyněk; Fučík, Petr

    2015-04-01

    In this paper, issues of agricultural drainage systems are introduced and discussed from the views of their former, current and future roles and functioning in the Czech Republic (CR). A methodologically disparate survey was done on thirty-nine model localities in CR with different intensity and state of land drainage systems, aimed at description of commonly occurred problems and possible adaptations of agricultural drainage as perceived by farmers, land owners, landscape managers or by protective water management. The survey was focused on technical state of drainage, fragmentation of land ownership within drained areas as well as on possible conflicts between agricultural and environmental interests in a landscape. Achieved results confirmed that there is obviously an increasing need to reassess some functions of prevailingly single-purpose agricultural drainage systems. Drainage intensity and detected unfavourable technical state of drainage systems as well as the risks connected with the anticipated climate change from the view of possible water scarcity claims for a complex solution. An array of adaptation options for agricultural drainage systems is presented, aiming at enhancement of water retention time and improvement of water quality. It encompasses additional flow-controlling measures on tiles or ditches, or facilities for making selected parts of a drainage system inoperable in order to retain or slow down the drainage runoff, to establish water accumulation zones and to enhance water self-cleaning processes. However, it was revealed that the question of landowner parcels fragmentation on drained land in CR would dramatically complicate design and realization of these measures. Presented solutions and findings are propounded with a respect to contemporary and future state policies and international strategies for sustainable agriculture, water management and environment.

  12. Comparison through a LCA evaluation analysis of food waste disposal options from the perspective of global warming and resource recovery.

    PubMed

    Kim, Mi-Hyung; Kim, Jung-Wk

    2010-09-01

    This study evaluated feed manufacturing including dry feeding and wet feeding, composting, and landfilling for food waste disposal options from the perspective of global warming and resource recovery. The method of the expanded system boundaries was employed in order to compare different by-products. The whole stages of disposal involved in the systems such as separate discharge, collection, transportation, treatment, and final disposal, were included in the system boundary and evaluated. The Global Warming Potential generated from 1tonne of food wastes for each disposal system was analyzed by the life cycle assessment method. The results showed that 200kg of CO(2)-eq could be produced from dry feeding process, 61kg of CO(2)-eq from wet feeding process, 123kg of CO(2)-eq from composting process, and 1010kg of CO(2)-eq from landfilling. Feed manufacturing and composting, the common treatment methods currently employed, have been known to be environment friendlier than other methods. However, this study shows that they can negatively affect the environment if their by-products are not appropriately utilized as intended.

  13. The RealGas and RealGasH2O Options of the TOUGH+ Code for the Simulation of Coupled Fluid and Heat Flow in Tight/Shale Gas Systems

    SciTech Connect

    Moridis, George; Freeman, Craig

    2013-09-30

    We developed two new EOS additions to the TOUGH+ family of codes, the RealGasH2O and RealGas . The RealGasH2O EOS option describes the non-isothermal two-phase flow of water and a real gas mixture in gas reservoirs, with a particular focus in ultra-tight (such as tight-sand and shale gas) reservoirs. The gas mixture is treated as either a single-pseudo-component having a fixed composition, or as a multicomponent system composed of up to 9 individual real gases. The RealGas option has the same general capabilities, but does not include water, thus describing a single-phase, dry-gas system. In addition to the standard capabilities of all members of the TOUGH+ family of codes (fully-implicit, compositional simulators using both structured and unstructured grids), the capabilities of the two codes include: coupled flow and thermal effects in porous and/or fractured media, real gas behavior, inertial (Klinkenberg) effects, full micro-flow treatment, Darcy and non-Darcy flow through the matrix and fractures of fractured media, single- and multi-component gas sorption onto the grains of the porous media following several isotherm options, discrete and fracture representation, complex matrix-fracture relationships, and porosity-permeability dependence on pressure changes. The two options allow the study of flow and transport of fluids and heat over a wide range of time frames and spatial scales not only in gas reservoirs, but also in problems of geologic storage of greenhouse gas mixtures, and of geothermal reservoirs with multi-component condensable (H2O and CH4) and non-condensable gas mixtures. The codes are verified against available analytical and semi-analytical solutions. Their capabilities are demonstrated in a series of problems of increasing complexity, ranging from isothermal flow in simpler 1D and 2D conventional gas reservoirs, to non-isothermal gas flow in 3D fractured shale gas reservoirs involving 4 types of fractures, micro-flow, non-Darcy flow and gas

  14. The RealGas and RealGasH2O options of the TOUGH+ code for the simulation of coupled fluid and heat flow in tight/shale gas systems

    NASA Astrophysics Data System (ADS)

    Moridis, George J.; Freeman, Craig M.

    2014-04-01

    We developed two new EOS additions to the TOUGH+ family of codes, the RealGasH2O and RealGas. The RealGasH2O EOS option describes the non-isothermal two-phase flow of water and a real gas mixture in gas reservoirs, with a particular focus in ultra-tight (such as tight-sand and shale gas) reservoirs. The gas mixture is treated as either a single-pseudo-component having a fixed composition, or as a multicomponent system composed of up to 9 individual real gases. The RealGas option has the same general capabilities, but does not include water, thus describing a single-phase, dry-gas system. In addition to the standard capabilities of all members of the TOUGH+ family of codes (fully-implicit, compositional simulators using both structured and unstructured grids), the capabilities of the two codes include coupled flow and thermal effects in porous and/or fractured media, real gas behavior, inertial (Klinkenberg) effects, full micro-flow treatment, Darcy and non-Darcy flow through the matrix and fractures of fractured media, single- and multi-component gas sorption onto the grains of the porous media following several isotherm options, discrete and fracture representation, complex matrix-fracture relationships, and porosity-permeability dependence on pressure changes. The two options allow the study of flow and transport of fluids and heat over a wide range of time frames and spatial scales not only in gas reservoirs, but also in problems of geologic storage of greenhouse gas mixtures, and of geothermal reservoirs with multi-component condensable (H2O and CH4) and non-condensable gas mixtures. The codes are verified against available analytical and semi-analytical solutions. Their capabilities are demonstrated in a series of problems of increasing complexity, ranging from isothermal flow in simpler 1D and 2D conventional gas reservoirs, to non-isothermal gas flow in 3D fractured shale gas reservoirs involving 4 types of fractures, micro-flow, non-Darcy flow and gas

  15. Innovating With Rehabilitation Technology in the Real World: Promises, Potentials, and Perspectives.

    PubMed

    Chua, Karen Sui Geok; Kuah, Christopher Wee Keong

    2017-10-01

    In this article, we discuss robotic-assisted therapy as an emerging and significant field of clinical rehabilitation and its value proposition for innovating rehabilitation clinical practice. Attempts to achieve integration among clinicians' practices and bioengineers' machines often generate new challenges and controversies. To date, the literature is indicative of a sizeable number and variety of robotic devices in the field of clinical rehabilitation, some are commercially available; however, large-scale clinical outcomes are less positive than expected. The following main themes related to integrating rehabilitation technology in real-world clinical practice will be discussed: the application of current evidence-based practice and knowledge in relation to treatment in the rehabilitation clinic, perspectives from rehabilitation professionals using robotic-aided therapy with regard to challenges, and strategies for problem solving. Lastly, we present innovation philosophies with regard to sustainability of clinical rehabilitation technologies.

  16. Real Time Semantic Interoperability in AD HOC Networks of Geospatial Data Sources: Challenges, Achievements and Perspectives

    NASA Astrophysics Data System (ADS)

    Mostafavi, M. A.; Bakillah, M.

    2012-07-01

    Recent advances in geospatial technologies have made available large amount of geospatial data. Meanwhile, new developments in Internet and communication technologies created a shift from isolated geospatial databases to ad hoc networks of geospatial data sources, where data sources can join or leave the network, and form groups to share data and services. However, effective integration and sharing of geospatial data among these data sources and their users are hampered by semantic heterogeneities. These heterogeneities affect the spatial, temporal and thematic aspects of geospatial concepts. There have been many efforts to address semantic interoperability issues in the geospatial domain. These efforts were mainly focused on resolving heterogeneities caused by different and implicit representations of the concepts. However, many approaches have focused on the thematic aspects, leaving aside the explicit representation of spatial and temporal aspects. Also, most semantic interoperability approaches for networks have focused on automating the semantic mapping process. However, the ad hoc network structure is continuously modified by source addition or removal, formation of groups, etc. This dynamic aspect is often neglected in those approaches. This paper proposes a conceptual framework for real time semantic interoperability in ad hoc networks of geospatial data sources. The conceptual framework presents the fundamental elements of real time semantic interoperability through a hierarchy of interrelated semantic states and processes. Then, we use the conceptual framework to set the discussion on the achievements that have already been made, the challenges that remain to be addressed and perspectives with respect to these challenges.

  17. An extension of the real option approach to the evaluation of health care technologies: the case of positron emission tomography.

    PubMed

    Pertile, Paolo

    2009-09-01

    This paper aims to incorporate option values into the economic evaluation of positron emission tomography (PET). The installation of this equipment requires a substantial capital outlay, while uncertainty, especially regarding the possibility of new applications, is relevant, because the evidence available is still insufficient. Treating the number of examinations to provide as a stochastic variable, the cost-effectiveness analysis is extended to include the value of flexibility both with respect to the timing of investment and to the size of the project. The threshold values of the stochastic variable that ensure the cost-effectiveness of a PET scan according to this approach are obtained as a function of the value of the incremental effectiveness.

  18. Social Cohesion as a Real-Life Phenomenon: Assessing the Explanatory Power of the Universalist and Particularist Perspectives

    ERIC Educational Resources Information Center

    Janmaat, Jan Germen

    2011-01-01

    Unlike most studies on social cohesion, this study explores the concept as a real-life macro-level phenomenon. It assesses to what extent the conceptions of social cohesion suggested by several macro-level approaches represent coherent empirically observable forms of social cohesion. Additionally it discusses two perspectives on social…

  19. Social Cohesion as a Real-Life Phenomenon: Assessing the Explanatory Power of the Universalist and Particularist Perspectives

    ERIC Educational Resources Information Center

    Janmaat, Jan Germen

    2011-01-01

    Unlike most studies on social cohesion, this study explores the concept as a real-life macro-level phenomenon. It assesses to what extent the conceptions of social cohesion suggested by several macro-level approaches represent coherent empirically observable forms of social cohesion. Additionally it discusses two perspectives on social…

  20. a Perspective on the Magic Square and the "special Unitary" Realization of Real Simple Lie Algebras

    NASA Astrophysics Data System (ADS)

    Santander, Mariano

    2013-07-01

    This paper contains the last part of the minicourse "Spaces: A Perspective View" delivered at the IFWGP2012. The series of three lectures was intended to bring the listeners from the more naive and elementary idea of space as "our physical Space" (which after all was the dominant one up to the 1820s) through the generalization of the idea of space which took place in the last third of the 19th century. That was a consequence of first the discovery and acceptance of non-Euclidean geometry and second, of the views afforded by the works of Riemann and Klein and continued since then by many others, outstandingly Lie and Cartan. Here we deal with the part of the minicourse which centers on the classification questions associated to the simple real Lie groups. We review the original introduction of the Magic Square "á la Freudenthal", putting the emphasis in the role played in this construction by the four normed division algebras ℝ, ℂ, ℍ, 𝕆. We then explore the possibility of understanding some simple real Lie algebras as "special unitary" over some algebras 𝕂 or tensor products 𝕂1 ⊗ 𝕂2, and we argue that the proper setting for this construction is not to confine only to normed division algebras, but to allow the split versions ℂ‧, ℍ‧, 𝕆‧ of complex, quaternions and octonions as well. This way we get a "Grand Magic Square" and we fill in all details required to cover all real forms of simple real Lie algebras within this scheme. The paper ends with the complete lists of all realizations of simple real Lie algebras as "special unitary" (or only unitary when n = 2) over some tensor product of two *-algebras 𝕂1, 𝕂2, which in all cases are obtained from ℝ, ℂ, ℂ‧, ℍ, ℍ‧, 𝕆, 𝕆‧ as sets, endowing them with a *-conjugation which usually but not always is the natural complex, quaternionic or octonionic conjugation.

  1. Needs of Near Real-Time Data: Perspectives for Supporting Disaster Observations -- Wildfires

    NASA Astrophysics Data System (ADS)

    Ambrosia, V. G.; Buechel, S.; Sullivan, D. V.; Enomoto, F. Y.; Hinkley, E.

    2010-12-01

    Between 2004 and 2010, the Wildfire Research and Applications Partnership (WRAP), a joint NASA / US Forest Service project, matured, demonstrated and transitioned innovative technologies and capabilities for real-time information data delivery to Incident Management Teams on wildland fires in the United States. The capabilities included the development of innovative unmanned airborne systems (UAS), multispectral sensors, on-board, real-time processing, and a COTS-driven visualization and common operating picture (COP) capability. The UAS airborne element involved demonstrating a medium-altitude, large payload capacity, long-duration, Unmanned Airborne Systems (UAS) the NASA Ikhana (Predator-B derivative). The sensor system, a redesigned Daedalus AADS1268 line-scanner with 16 spectral channels (VIS-IR-TIR), was further modified to allow long-duration mission capabilities, and full on-board geo-rectification and second-generation product development for delivery through a UAS / SatCom / Ground data telemetry system. The COP, the Collaborative Decision Environment (CDE) based on a mash-up of wildfire intelligence data in GoogleEarth, enabled operational use of the real-time UAS-acquired sensor data, along with other critical geospatial fire / weather data for incident management team use and visualization. The CDE allowed the shared integration of various additional asset information sets (satellite, other airborne sensor data, and ground condition information, comprising a simplified sensor web concept design. All of these capabilities and advancements are described from both a development and “end-user” perspective. The wildfire management agency end-users (primarily the U.S. Forest Service), are currently adopting some of these capabilities into operational utility. An assessment of the gaps in adaptation will also be addressed.

  2. Reproductive rights and options available to women infected with HIV in Ghana: perspectives of service providers from three Ghanaian health facilities.

    PubMed

    Laar, Amos Kankponang

    2013-03-15

    Owing to improved management of HIV and its associated opportunistic infections, many HIV-positive persons of reproductive age are choosing to exercise their right of parenthood. This study explored the knowledge of health workers from two Ghanaian districts on the reproductive rights and options available to HIV-positive women who wish to conceive. Facility-based cross-sectional in design, the study involved the entire population of nurse counselors (32) and medical officers (3) who provide counseling and testing services to clients infected with HIV. Both structured and in-depth interviews were conducted after informed consent. Two main perspectives were revealed. There was an overwhelmingly high level of approbation by the providers on HIV-positive women's right to reproduction (94.3%). At the same time, the providers demonstrated a lack of knowledge regarding the various reproductive options available to women infected with HIV. Site of facility, and being younger were associated with practices that violated client's right to contraceptive counseling (p < 0.05) in each case. Some of the providers openly expressed their inability to give qualified guidance to HIV-positive women on the various reproductive options. Taken together, these findings suggest that many HIV-positive clients do not receive comprehensive information about their reproductive options. These findings highlight some of the problems that service providers face as HIV counselors. Both service providers and policy makers need to recognize these realities and incorporate reproductive health issues of HIV-persons into the existing guidelines.

  3. A Case Study on the Perspectives of an Optional K-5 Year-Round/Multi-Age Program in Virginia.

    ERIC Educational Resources Information Center

    Morris, Roger N.

    Noting that the growing popularity of year-round schools (extended calendar without increasing the number of school days) has coincided with an increase in school accountability, this report provides a descriptive case study on one year-round school located within a large elementary school district in central Virginia. An optional year-round…

  4. Uncooled Terahertz real-time imaging 2D arrays developed at LETI: present status and perspectives

    NASA Astrophysics Data System (ADS)

    Simoens, François; Meilhan, Jérôme; Dussopt, Laurent; Nicolas, Jean-Alain; Monnier, Nicolas; Sicard, Gilles; Siligaris, Alexandre; Hiberty, Bruno

    2017-05-01

    As for other imaging sensor markets, whatever is the technology, the commercial spread of terahertz (THz) cameras has to fulfil simultaneously the criteria of high sensitivity and low cost and SWAP (size, weight and power). Monolithic silicon-based 2D sensors integrated in uncooled THz real-time cameras are good candidates to meet these requirements. Over the past decade, LETI has been studying and developing such arrays with two complimentary technological approaches, i.e. antenna-coupled silicon bolometers and CMOS Field Effect Transistors (FET), both being compatible to standard silicon microelectronics processes. LETI has leveraged its know-how in thermal infrared bolometer sensors in developing a proprietary architecture for THz sensing. High technological maturity has been achieved as illustrated by the demonstration of fast scanning of large field of view and the recent birth of a commercial camera. In the FET-based THz field, recent works have been focused on innovative CMOS read-out-integrated circuit designs. The studied architectures take advantage of the large pixel pitch to enhance the flexibility and the sensitivity: an embedded in-pixel configurable signal processing chain dramatically reduces the noise. Video sequences at 100 frames per second using our 31x31 pixels 2D Focal Plane Arrays (FPA) have been achieved. The authors describe the present status of these developments and perspectives of performance evolutions are discussed. Several experimental imaging tests are also presented in order to illustrate the capabilities of these arrays to address industrial applications such as non-destructive testing (NDT), security or quality control of food.

  5. Climate change and the economics of biomass energy feedstocks in semi-arid agricultural landscapes: A spatially explicit real options analysis.

    PubMed

    Regan, Courtney M; Connor, Jeffery D; Raja Segaran, Ramesh; Meyer, Wayne S; Bryan, Brett A; Ostendorf, Bertram

    2017-05-01

    The economics of establishing perennial species as renewable energy feedstocks has been widely investigated as a climate change adapted diversification option for landholders, primarily using net present value (NPV) analysis. NPV does not account for key uncertainties likely to influence relevant landholder decision making. While real options analysis (ROA) is an alternative method that accounts for the uncertainty over future conditions and the large upfront irreversible investment involved in establishing perennials, there have been limited applications of ROA to evaluating land use change decision economics and even fewer applications considering climate change risks. Further, while the influence of spatially varying climate risk on biomass conversion economic has been widely evaluated using NPV methods, effects of spatial variability and climate on land use change have been scarcely assessed with ROA. In this study we applied a simulation-based ROA model to evaluate a landholder's decision to convert land from agriculture to biomass. This spatially explicit model considers price and yield risks under baseline climate and two climate change scenarios over a geographically diverse farming region. We found that underlying variability in primary productivity across the study area had a substantial effect on conversion thresholds required to trigger land use change when compared to results from NPV analysis. Areas traditionally thought of as being quite similar in average productive capacity can display large differences in response to the inclusion of production and price risks. The effects of climate change, broadly reduced returns required for land use change to biomass in low and medium rainfall zones and increased them in higher rainfall areas. Additionally, the risks posed by climate change can further exacerbate the tendency for NPV methods to underestimate true conversion thresholds. Our results show that even under severe drying and warming where crop yield

  6. Reproductive rights and options available to women infected with HIV in Ghana: perspectives of service providers from three Ghanaian health facilities

    PubMed Central

    2013-01-01

    Background Owing to improved management of HIV and its associated opportunistic infections, many HIV-positive persons of reproductive age are choosing to exercise their right of parenthood. This study explored the knowledge of health workers from two Ghanaian districts on the reproductive rights and options available to HIV-positive women who wish to conceive. Methods Facility-based cross-sectional in design, the study involved the entire population of nurse counselors (32) and medical officers (3) who provide counseling and testing services to clients infected with HIV. Both structured and in-depth interviews were conducted after informed consent. Results Two main perspectives were revealed. There was an overwhelmingly high level of approbation by the providers on HIV-positive women’s right to reproduction (94.3%). At the same time, the providers demonstrated a lack of knowledge regarding the various reproductive options available to women infected with HIV. Site of facility, and being younger were associated with practices that violated client’s right to contraceptive counseling (p < 0.05) in each case. Some of the providers openly expressed their inability to give qualified guidance to HIV-positive women on the various reproductive options. Conclusions Taken together, these findings suggest that many HIV-positive clients do not receive comprehensive information about their reproductive options. These findings highlight some of the problems that service providers face as HIV counselors. Both service providers and policy makers need to recognize these realities and incorporate reproductive health issues of HIV-persons into the existing guidelines. PMID:23496943

  7. Future electricity generation: An economic and environmental life cycle perspective on near-, mid- and long-term technology options and policy implications

    NASA Astrophysics Data System (ADS)

    Bergerson, Joule Andrea

    This thesis evaluates the cost and environmental tradeoffs of current and future electricity generation options from a life cycle perspective. Policy and technology options are considered for each critical time horizon (near-, mid-, and long-term). The framework developed for this analysis is a hybrid life cycle analysis which integrates several models and frameworks including process and input-output life cycle analysis, an integrated environmental control model, social costing, forecasting and future energy scenario analysis. The near-term analysis shows that several recent LCA studies of electricity options have contributed to our understanding of the technologies available and their relative environmental impacts. Several promising options could satisfy our electricity demands. Other options remain unproven or too costly to encourage investment in the near term but show promise for future use (e.g. photovoltaic, fuel cells). Public concerns could impede the use of some desirable technologies (e.g. hydro, nuclear). Finally, less tangible issues such as intermittency of some renewable technologies, social equity and visual and land use impacts, while difficult to quantify, must be considered in the investment decision process. In the mid-term analysis, this thesis explores alternative methods for transport of coal energy. A hybrid life cycle analysis is critical for evaluating the cost, efficiency and environmental tradeoffs of the entire system. If a small amount of additional coal is to be shipped, current rail infrastructure should be used where possible. If entirely new infrastructure is required, the mine mouth generation options are cheaper but have increased environmental impact due to the increased generation required to compensate for transmission line losses. Gasifying the coal to produce methane also shows promise in terms of lowering environmental emissions. The long-term analysis focuses on the implications of a high coal use future. This scenario

  8. Quantifying the value of investing in distributed natural gas and renewable electricity systems as complements: Applications of discounted cash flow and real options analysis with stochastic inputs

    SciTech Connect

    Pless, Jacquelyn; Arent, Douglas J.; Logan, Jeffrey; Cochran, Jaquelin; Zinaman, Owen

    2016-10-01

    One energy policy objective in the United States is to promote the adoption of technologies that provide consumers with stable, secure, and clean energy. Recent work provides anecdotal evidence of natural gas (NG) and renewable electricity (RE) synergies in the power sector, however few studies quantify the value of investing in NG and RE systems together as complements. This paper uses discounted cash flow analysis and real options analysis to value hybrid NG-RE systems in distributed applications, focusing on residential and commercial projects assumed to be located in the states of New York and Texas. Technology performance and operational risk profiles are modeled at the hourly level to capture variable RE output and NG prices are modeled stochastically as geometric Ornstein-Uhlenbeck (OU) stochastic processes to capture NG price uncertainty. The findings consistently suggest that NG-RE hybrid distributed systems are more favorable investments in the applications studied relative to their single-technology alternatives when incentives for renewables are available. In some cases, NG-only systems are the favorable investments. Understanding the value of investing in NG-RE hybrid systems provides insights into one avenue towards reducing greenhouse gas emissions, given the important role of NG and RE in the power sector.

  9. Using life cycle assessment and techno-economic analysis in a real options framework to inform the design of algal biofuel production facilities.

    PubMed

    Kern, Jordan D; Hise, Adam M; Characklis, Greg W; Gerlach, Robin; Viamajala, Sridhar; Gardner, Robert D

    2017-02-01

    This study investigates the use of "real options analysis" (ROA) to quantify the value of greater product flexibility at algal biofuel production facilities. A deterministic optimization framework is integrated with a combined life cycle assessment/techno-economic analysis model and subjected to an ensemble of 30-year commodity price trajectories. Profits are maximized for two competing plant configurations: 1) one that sells lipid-extracted algae as animal feed only; and 2) one that can sell lipid-extracted algae as feed or use it to recover nutrients and energy, due to an up-front investment in anaerobic digestion/combined heat and power. Results show that added investment in plant flexibility does not result in an improvement in net present value, because current feed meal prices discourage use of lipid-extracted algae for nutrient and energy recovery. However, this study demonstrates that ROA provides many useful insights regarding plant design that cannot be captured via traditional techno-economic modeling.

  10. Optional real-time display of intraoperative neurophysiological monitoring in the microscopic field of view: avoiding communication failures in the operating room.

    PubMed

    Stoecklein, Veit M; Faber, Florian; Koch, Mandy; Mattmüller, Rudi; Schaper, Anika; Rudolph, Frank; Tonn, Joerg C; Schichor, Christian

    2015-11-01

    The use of intraoperative neurophysiological monitoring (IONM) in neurosurgery has improved patient safety and outcomes. However, a pitfall in the use of IONM remains unsolved. Currently, there is no feasible way for surgeons to interpret IONM waves themselves during operations. Instead, they have to rely on verbal feedback from a neurophysiologist. This method is prone to communication failures, which can lead to delayed or false interpretation of the data. Direct visualization of IONM waves is a way to alleviate this problem and make IONM more effective. Microscope-integrated IONM (MI-IONM) was used in 163 cranial and spinal cases. We evaluated the feasibility, system stability and how well the system integrated into the surgical workflow. We used an IONM system that was connected to a surgical microscope. All IONM modalities used at our institution could be visualized as required, superimposed on the surgical field in the eyepiece of the microscope without obstructing the surgeon's field of vision. Use of MI-IONM was safe and reliable. It furthermore provided valuable intraoperative information. The system merely required a short learning curve. Only minor system problems without impact on surgical workflow occurred. MI-IONM proved to be especially useful in surgical cases where careful monitoring of nerve function is required, e.g., cerebellopontine angle surgery. Here, direct assessment of surgical action and IONM wave change was provided to the surgeon, if necessary (on-off control). MI-IONM is a useful extension of conventional IONM that provides optional real-time functional information to the surgeon on demand.

  11. An Estimation of Profitability of Investment Projects in The Oil and Gas Industry Using Real Options Theory / Ocena Opłacalności Projektów Inwestycyjnych W Przemyśle Naftowym Z Wykorzystaniem Teorii Opcji Realnych

    NASA Astrophysics Data System (ADS)

    Kosowski, Piotr; Stopa, Jerzy

    2012-11-01

    Paper discusses issues relating to the valuation of investment efficiency in the oil and gas industry using a real options theory. The example of investment pricing using real options was depicted and it was confronted with the analysis executed with the use of traditional methods. Indicators commonly used to evaluate profitability of investment projects, based on a discounted cash flow method, have a few significant drawbacks, the most meaningful of which is staticity which means that any changes resulting from a decision process during the time of investment cannot be taken into consideration. In accordance with a methodology that is currently used, investment projects are analysed in a way that all the key decisions are made at the beginning and are irreversible. This approach assumes, that all the cash flows are specified and does not let the fact that during the time of investment there may appear new information, which could change its original form. What is also not analysed is the possibility of readjustment, due to staff managment's decisions, to the current market conditions, by expanding, speeding up/slowing down, abandoning or changing an outline of the undertaking. In result, traditional methods of investment projects valuation may lead to taking wrong decisions, e.g. giving up an owned exploitation licence or untimely liquidation of boreholes, which seem to be unprofitable. Due to all the above-mentioned there appears the necessity of finding some other methods which would let one make real and adequate estimations about investments in a petroleum industry especially when it comes to unconventional resources extraction. One of the methods which has been recently getting more and more approval in a world petroleum economics, is a real options pricing method. A real option is a right (but not an obligation) to make a decision connected with an investment in a specified time or time interval. According to the method a static model of pricing using DCF is

  12. Rehabilitation Options

    MedlinePlus

    ... Speech Pathology Occupational Therapy Art Therapy Recreational therapy Neuropsychology Home Care Options Advanced Care Planning Palliative Care ... Speech Pathology Occupational Therapy Art Therapy Recreational therapy Neuropsychology Home Care Options Advanced Care Planning Palliative Care ...

  13. Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives

    PubMed Central

    Ausoni, Simonetta; Boscolo-Rizzo, Paolo; Singh, Bhuvanesh; da Mosto, Maria Cristina; Spinato, Giacomo; Tirelli, Giancarlo; Spinato, Roberto; Azzarello, Giuseppe

    2017-01-01

    Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance and the propensity for locoregional recurrence. Countering this, demands a significant effort from both basic and clinical scientists in the search for more-effective targeted therapies. Recent genomewide studies have provided valuable insights into the genetic basis of HNSCC, uncovering potential new therapeutic opportunities. In addition, several studies have elucidated how inflammatory, immune, and stromal cells contribute to the particular properties of these neoplasms. In the present review, we introduce recent findings on genomic aberrations resulting from whole-genome sequencing of HNSCC, we discuss how the particular microenvironment affects the pathogenesis of this disease, and we describe clinical trials exploring new perspectives on the use of combined genetic and cellular targeted therapies. PMID:27194534

  14. Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives.

    PubMed

    Ausoni, Simonetta; Boscolo-Rizzo, Paolo; Singh, Bhuvanesh; Da Mosto, Maria Cristina; Spinato, Giacomo; Tirelli, Giancarlo; Spinato, Roberto; Azzarello, Giuseppe

    2016-09-01

    Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance and the propensity for locoregional recurrence. Countering this, it demands a significant effort from both basic and clinical scientists in the search for more effective targeted therapies. Recent genomewide studies have provided valuable insights into the genetic basis of HNSCC, uncovering potential new therapeutic opportunities. In addition, several studies have elucidated how inflammatory, immune, and stromal cells contribute to the particular properties of these neoplasms. In the present review, we introduce recent findings on genomic aberrations resulting from whole-genome sequencing of HNSCC, we discuss how the particular microenvironment affects the pathogenesis of this disease, and we describe clinical trials exploring new perspectives on the use of combined genetic and cellular targeted therapies.

  15. Collagenase Clostridium Histolyticum for the Treatment of Peyronie's Disease: A 'Real World' Clinical Perspective.

    PubMed

    Anaissie, James; Hellstrom, Wayne J G; Yafi, Faysal A

    2016-10-01

    The introduction of collagenase Clostridium histolyticum (CCH) as a treatment option for Peyronie's disease (PD), defined as the abnormal formation of collagen on the tunica albuginea of the penis, has provided patients with a promising new conservative therapy. Studies have shown that CCH improves curvature by an average of 17°, and although patient and sexual partner satisfaction is high, the improvement has arguable clinical implications. Similarly, the efficacy and cost of CCH contrasts strongly with more invasive surgical management, and is further limited by rare, but serious, complications and several contraindications. The future of CCH involves well-designed trials analyzing the effects of CCH on patients who are currently not indicated for therapy, and the optimal amount of treatment for the most efficient treatment possible. CCH provides a promising treatment option for patients who do not desire invasive management, but need further trials to fully elucidate its treatment implications.

  16. Pricing Options.

    ERIC Educational Resources Information Center

    Tenopir, Carol

    1998-01-01

    Presents results of a recent survey of over 100 public and academic libraries about pricing options from online companies. Most options fall into three categories: pay-as-you-go, fixed-rate, and user-based. Results are discussed separately for public and academic libraries and for consortial discounts. Trends in pricing options preferred by…

  17. Pricing Options.

    ERIC Educational Resources Information Center

    Tenopir, Carol

    1998-01-01

    Presents results of a recent survey of over 100 public and academic libraries about pricing options from online companies. Most options fall into three categories: pay-as-you-go, fixed-rate, and user-based. Results are discussed separately for public and academic libraries and for consortial discounts. Trends in pricing options preferred by…

  18. A study on real-time low-quality content detection on Twitter from the users’ perspective

    PubMed Central

    Yeo, Chai Kiat; Lau, Chiew Tong; Lee, Bu Sung

    2017-01-01

    Detection techniques of malicious content such as spam and phishing on Online Social Networks (OSN) are common with little attention paid to other types of low-quality content which actually impacts users’ content browsing experience most. The aim of our work is to detect low-quality content from the users’ perspective in real time. To define low-quality content comprehensibly, Expectation Maximization (EM) algorithm is first used to coarsely classify low-quality tweets into four categories. Based on this preliminary study, a survey is carefully designed to gather users’ opinions on different categories of low-quality content. Both direct and indirect features including newly proposed features are identified to characterize all types of low-quality content. We then further combine word level analysis with the identified features and build a keyword blacklist dictionary to improve the detection performance. We manually label an extensive Twitter dataset of 100,000 tweets and perform low-quality content detection in real time based on the characterized significant features and word level analysis. The results of our research show that our method has a high accuracy of 0.9711 and a good F1 of 0.8379 based on a random forest classifier with real time performance in the detection of low-quality content in tweets. Our work therefore achieves a positive impact in improving user experience in browsing social media content. PMID:28793347

  19. Getting Ready for the Real World: Student Perspectives on Bringing Industry Collaboration into the Classroom

    ERIC Educational Resources Information Center

    Marcketti, Sara B.; Karpova, Elena

    2014-01-01

    Learning through industry collaborations is critical in decreasing the gap between the real world and the academic environment. Working on challenges drawn from industry can increase students' knowledge and future employability, thus enhancing labor force preparation. This study explored students' perceptions (n = 110) of the benefits…

  20. Getting Real: A Different Perspective on the Relationship between School Resources and Student Outcomes

    ERIC Educational Resources Information Center

    Greene, G. Kennedy; Huerta, Luis A.; Richards, Craig

    2007-01-01

    Most research on the association between school resources and student outcomes has concentrated on finances as measured in dollars. This study takes a fresh look at the issue by focusing on the allocation of real resources, defined as the personnel and materiel used to increase student learning, which are more relevant measures of a school's…

  1. The "Real Value" of Field Trips in the Early Weeks of Higher Education: The Student Perspective

    ERIC Educational Resources Information Center

    Larsen, C.; Walsh, C.; Almond, N.; Myers, C.

    2017-01-01

    The benefits attributed to field trips by science educators are: social development; observation and perception skills; giving meaning to learning; providing first-hand experience and stimulating interest and motivation. Arguably, the "real value" of field work is attributed by students. In this study, 100 first-year students took part…

  2. The "Real Value" of Field Trips in the Early Weeks of Higher Education: The Student Perspective

    ERIC Educational Resources Information Center

    Larsen, C.; Walsh, C.; Almond, N.; Myers, C.

    2017-01-01

    The benefits attributed to field trips by science educators are: social development; observation and perception skills; giving meaning to learning; providing first-hand experience and stimulating interest and motivation. Arguably, the "real value" of field work is attributed by students. In this study, 100 first-year students took part…

  3. Getting Ready for the Real World: Student Perspectives on Bringing Industry Collaboration into the Classroom

    ERIC Educational Resources Information Center

    Marcketti, Sara B.; Karpova, Elena

    2014-01-01

    Learning through industry collaborations is critical in decreasing the gap between the real world and the academic environment. Working on challenges drawn from industry can increase students' knowledge and future employability, thus enhancing labor force preparation. This study explored students' perceptions (n = 110) of the benefits…

  4. Deception Detection: The Relationship of Levels of Trust and Perspective Taking in Real-Time Online and Offline Communication Environments.

    PubMed

    Friend, Catherine; Fox Hamilton, Nicola

    2016-09-01

    Where humans have been found to detect lies or deception only at the rate of chance in offline face-to-face communication (F2F), computer-mediated communication (CMC) online can elicit higher rates of trust and sharing of personal information than F2F. How do levels of trust and empathetic personality traits like perspective taking (PT) relate to deception detection in real-time CMC compared to F2F? A between groups correlational design (N = 40) demonstrated that, through a paired deceptive conversation task with confederates, levels of participant trust could predict accurate detection online but not offline. Second, participant PT abilities could not predict accurate detection in either conversation medium. Finally, this study found that conversation medium also had no effect on deception detection. This study finds support for the effects of the Truth Bias and online disinhibition in deception, and further implications in law enforcement are discussed.

  5. A real options model to assess the role of flexibility in forestry and agroforestry adoption and disadoption in the Lower Mississippi Alluvial Valley

    Treesearch

    Gregory E. Frey; D. Evan Mercer; Frederick W. Cubbage; Robert C. Abt

    2013-01-01

    Efforts to restore the Lower Mississippi Alluvial Valley’s forests have not achieved desired levels of ecosystem services production.We examined how the variability of returns and the flexibility to change or postpone decisions (option value) affects the economic potential of forestry and agroforestry systems to keep private land in production while still providing...

  6. A dynamical systems perspective for a real-time response to a marine oil spill.

    PubMed

    García-Garrido, V J; Ramos, A; Mancho, A M; Coca, J; Wiggins, S

    2016-11-15

    This paper discusses the combined use of tools from dynamical systems theory and remote sensing techniques and shows how they are effective instruments which may greatly contribute to the decision making protocols of the emergency services for the real-time management of oil spills. This work presents the successful interplay of these techniques for a recent situation, the sinking of the Oleg Naydenov fishing ship that took place in Spain, close to the Canary Islands, in April 2015. Copyright © 2016. Published by Elsevier Ltd.

  7. The Fusion Energy Option

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.

    2004-06-01

    Presentations from a Fusion Power Associates symposium, The Fusion Energy Option, are summarized. The topics include perspectives on fossil fuel reserves, fusion as a source for hydrogen production, status and plans for the development of inertial fusion, planning for the construction of the International Thermonuclear Experimental Reactor, status and promise of alternate approaches to fusion and the need for R&D now on fusion technologies.

  8. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives.

    PubMed

    Balistreri, Carmela R; Buffa, Silvio; Pisano, Calogera; Lio, Domenico; Ruvolo, Giovanni; Mazzesi, Giuseppe

    2015-01-01

    Advanced knowledge in the field of stem cell biology and their ability to provide a cue for counteracting several diseases are leading numerous researchers to focus their attention on "regenerative medicine" as possible solutions for cardiovascular diseases (CVDs). However, the lack of consistent evidence in this arena has hampered the clinical application. The same condition affects the research on endothelial progenitor cells (EPCs), creating more confusion than comprehension. In this review, this aspect is discussed with particular emphasis. In particular, we describe biology and physiology of EPCs, outline their clinical relevance as both new predictive, diagnostic, and prognostic CVD biomarkers and therapeutic agents, discuss advantages, disadvantages, and conflicting data about their use as possible solutions for vascular impairment and clinical applications, and finally underline a very crucial aspect of EPCs "characterization and definition," which seems to be the real cause of large heterogeneity existing in literature data on this topic.

  9. Is the GSI anomaly due to neutrino oscillations? A real time perspective

    SciTech Connect

    Wu Jun; Boyanovsky, Daniel; Hutasoit, Jimmy A.; Holman, Richard

    2010-08-15

    We study a model for the 'GSI anomaly' in which we obtain the time evolution of the population of parent and daughter particles directly in real time, considering explicitly the quantum entanglement between the daughter particle and neutrino mass eigenstates in the two-body decay. We confirm that the decay rate of the parent particle and the growth rate of the daughter particle do not feature a time modulation from interference of neutrino mass eigenstates. The lack of interference is a consequence of the orthogonality of the mass eigenstates. This result also follows from the density matrix obtained by tracing out the unobserved neutrino states. We confirm this result by providing a complementary explanation based on Cutkosky rules applied to the Feynman diagram that describes the self energy of the parent particle.

  10. A comparative study on real lab and simulation lab in communication engineering from students' perspectives

    NASA Astrophysics Data System (ADS)

    Balakrishnan, B.; Woods, P. C.

    2013-05-01

    Over the years, rapid development in computer technology has engendered simulation-based laboratory (lab) in addition to the traditional hands-on (physical) lab. Many higher education institutions adopt simulation lab, replacing some existing physical lab experiments. The creation of new systems for conducting engineering lab activities has raised concerns among educators on the merits and shortcomings of both physical and simulation labs; at the same time, many arguments have been raised on the differences of both labs. Investigating the effectiveness of both labs is complicated, as there are multiple factors that should be considered. In view of this challenge, a study on students' perspectives on their experience related to key aspects on engineering laboratory exercise was conducted. In this study, the Visual Auditory Read and Kinetic model was utilised to measure the students' cognitive styles. The investigation was done through a survey among participants from Multimedia University, Malaysia. The findings revealed that there are significant differences for most of the aspects in physical and simulation labs.

  11. Expensing options solves nothing.

    PubMed

    Sahlman, William A

    2002-12-01

    The use of stock options for executive compensation has become a lightning rod for public anger, and it's easy to see why. Many top executives grew hugely rich on the back of the gains they made on their options, profits they've been able to keep even as the value they were supposed to create disappeared. The supposed scam works like this: Current accounting regulations let companies ignore the cost of option grants on their income statements, so they can award valuable option packages without affecting reported earnings. Not charging the cost of the grants supposedly leads to overstated earnings, which purportedly translate into unrealistically high share prices, permitting top executives to realize big gains when they exercise their options. If an accounting anomaly is the problem, then the solution seems obvious: Write off executive share options against the current year's revenues. The trouble is, Sahlman writes, expensing option grants won't give us a more accurate view of earnings, won't add any information not already included in the financial statements, and won't even lead to equal treatment of different forms of executive pay. Far worse, expensing evades the real issue, which is whether compensation (options and other-wise) does what it's supposed to do--namely, help a company recruit, retain, and provide the right people with appropriate performance incentives. Any performance-based compensation system has the potential to encourage cheating. Only ethical management, sensible governance, adequate internal control systems, and comprehensive disclosure will save the investor from disaster. If, Sahlman warns, we pass laws that require the expensing of options, thinking that's fixed the fundamental flaws in corporate America's accounting, we will have missed a golden opportunity to focus on the much more extensive defects in the present system.

  12. Chemical bonding in excited states: Energy transfer and charge redistribution from a real space perspective.

    PubMed

    Jara-Cortés, Jesús; Guevara-Vela, José Manuel; Martín Pendás, Ángel; Hernández-Trujillo, Jesús

    2017-05-15

    This work provides a novel interpretation of elementary processes of photophysical relevance from the standpoint of the electron density using simple model reactions. These include excited states of H2 taken as a prototype for a covalent bond, excimer formation of He2 to analyze non-covalent interactions, charge transfer by an avoided crossing of electronic states in LiF and conical interesections involved in the intramolecular scrambling in C2 H4 . The changes of the atomic and interaction energy components along the potential energy profiles are described by the interacting quantum atoms approach and the quantum theory of atoms in molecules. Additionally, the topological analysis of one- and two-electron density functions is used to explore basic reaction mechanisms involving excited and degenerate states in connection with the virial theorem. This real space approach allows to describe these processes in a unified way, showing its versatility and utility in the study of chemical systems in excited states. © 2017 Wiley Periodicals, Inc.

  13. Real or Artificial? Intergroup Biases in Mind Perception in a Cross-Cultural Perspective

    PubMed Central

    Krumhuber, Eva G.; Swiderska, Aleksandra; Tsankova, Elena; Kamble, Shanmukh V.; Kappas, Arvid

    2015-01-01

    Recent research suggests that attributions of aliveness and mental capacities to faces are influenced by social group membership. In this article, we investigated group related biases in mind perception in participants from a Western and Eastern culture, employing faces of varying ethnic groups. In Experiment 1, Caucasian faces that ranged on a continuum from real to artificial were evaluated by participants in the UK (in-group) and in India (out-group) on animacy, abilities to plan and to feel pain, and having a mind. Human features were found to be assigned to a greater extent to faces when these belonged to in-group members, whereas out-group faces had to appear more realistic in order to be perceived as human. When participants in India evaluated South Asian (in-group) and Caucasian (out-group) faces in Experiment 2, the results closely mirrored those of the first experiment. For both studies, ratings of out-group faces were significantly predicted by participants’ levels of ethnocultural empathy. The findings highlight the role of intergroup processes (i.e., in-group favoritism, out-group dehumanization) in the perception of human and mental qualities and point to ethnocultural empathy as an important factor in responses to out-groups. PMID:26360588

  14. Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective.

    PubMed

    Homaira, Nusrat; Rawlinson, William; Snelling, Thomas L; Jaffe, Adam

    2014-01-01

    Infection with respiratory syncytial virus (RSV) is one of the major causes globally of childhood respiratory morbidity and hospitalization. Palivizumab, a humanized monoclonal antibody, has been recommended for high risk infants to prevent severe RSV-associated respiratory illness. This recommendation is based on evidence of efficacy when used under clinical trial conditions. However the real-world effectiveness of palivizumab outside of clinical trials among different patient populations is not well established. We performed a systematic review focusing on postlicensure observational studies of the protective effect of palivizumab prophylaxis for reducing RSV-associated hospitalizations in infants and children at high risk of severe infection. We searched studies published in English between 1 January 1999 and August 2013 and identified 420 articles, of which 20 met the inclusion criteria. This review supports the recommended use of palivizumab for reducing RSV-associated hospitalization rates in premature infants born at gestational age < 33 weeks and in children with chronic lung and heart diseases. Data are limited to allow commenting on the protective effect of palivizumab among other high risk children, including those with Down syndrome, cystic fibrosis, and haematological malignancy, indicating further research is warranted in these groups.

  15. Real or Artificial? Intergroup Biases in Mind Perception in a Cross-Cultural Perspective.

    PubMed

    Krumhuber, Eva G; Swiderska, Aleksandra; Tsankova, Elena; Kamble, Shanmukh V; Kappas, Arvid

    2015-01-01

    Recent research suggests that attributions of aliveness and mental capacities to faces are influenced by social group membership. In this article, we investigated group related biases in mind perception in participants from a Western and Eastern culture, employing faces of varying ethnic groups. In Experiment 1, Caucasian faces that ranged on a continuum from real to artificial were evaluated by participants in the UK (in-group) and in India (out-group) on animacy, abilities to plan and to feel pain, and having a mind. Human features were found to be assigned to a greater extent to faces when these belonged to in-group members, whereas out-group faces had to appear more realistic in order to be perceived as human. When participants in India evaluated South Asian (in-group) and Caucasian (out-group) faces in Experiment 2, the results closely mirrored those of the first experiment. For both studies, ratings of out-group faces were significantly predicted by participants' levels of ethnocultural empathy. The findings highlight the role of intergroup processes (i.e., in-group favoritism, out-group dehumanization) in the perception of human and mental qualities and point to ethnocultural empathy as an important factor in responses to out-groups.

  16. Improving HCV cure rates in HIV-coinfected patients - a real-world perspective.

    PubMed

    Lakshmi, Seetha; Alcaide, Maria; Palacio, Ana M; Shaikhomer, Mohammed; Alexander, Abigail L; Gill-Wiehl, Genevieve; Pandey, Aman; Patel, Kunal; Jayaweera, Dushyantha; Del Pilar Hernandez, Maria

    2016-05-01

    To study rates and predictors of hepatitis C virus (HCV) cure among human immunodeficiency virus (HIV)/HCV-coinfected patients, and then to evaluate the effect of attendance at clinic visits on HCV cure. Retrospective cohort study of adult HIV/HCV-coinfected patients who initiated and completed treatment for HCV with direct-acting antivirals (DAAs) between January 1, 2014, and June 30, 2015. Eighty-four participants reported completing treatment. The median age was 58 years (interquartile ratio, 50-66); 88% were male and 50% were black. One-third were cirrhotic and half were HCV-treatment-experienced. The most commonly used regimen was sofosbuvir/ledipasvir (40%) followed by simeprevir/sofosbuvir (30%). Cure was achieved in 83.3%, 11.9% relapsed, and 2.3% experienced virological breakthrough. Two patients (2.3%) did not complete treatment based on pill counts and follow-up visit documentation. In multivariable analysis, cure was associated with attendance at follow-up clinic visits (odds ratio [OR], 9.0; 95% CI, 2.91-163) and with use of an integrase-based HIV regimen versus other non-integrase regimens, such as non-nucleoside analogues or protease inhibitors (OR, 6.22; 95% CI 1.81-141). Age, race, genotype, presence of cirrhosis, prior HCV treatment, HCV regimen, and pre-treatment CD4 counts were not associated with cure. Real-world HCV cure rates with DAAs in HCV/HIV coinfection are lower than those seen in clinical trials. Cure is associated with attendance at follow-up clinic visits and with use of an integrase-based HIV regimen. Future studies should evaluate best antiretroviral regimens, predictors of attendance at follow-up visits, impact of different monitoring protocols on medication adherence, and interventions to ensure adequate models of HIV/HCV care.

  17. “Shielded from the Real World”: Perspectives on Internet Cancer Support Groups by Asian Americans

    PubMed Central

    Im, Eun-Ok; Lee, Bok Im; Chee, Wonshik

    2010-01-01

    Background Despite positive reports about Internet cancer support groups (ICSGs), ethnic minorities, including Asian Americans, have been reported to be less likely to use ICSGs. Unique cultural values, beliefs, and attitudes have been considered reasons for the low usage rate of ICSGs among Asian Americans. However, studies have rarely looked at this issue. Objective The purpose of this study was to explore (a) how Asian Americans living with cancer who participated in ICSGs viewed ICSGs, (b) what facilitated or inhibited their participation in ICSGs, and (c) what cultural values and beliefs influenced their participation in ICSGs. Methods The study was a one-month qualitative online forum among 18 Asian American cancer patients recruited through a convenience sampling method. Nine topics on the use of ICSGs organized the forum discussion, and the data were analyzed using thematic analysis. Results Four themes emerged from the data analysis process: (a) “more than just my family,” (b) “part of my family,” (c) “anonymous me,” and (d) “shielded from the real world.” Conclusions The overarching theme was Asian Americans’ marginalized experience in the use of Internet cancer support groups. Implications for Practice Offering the most current information on cancer and cancer treatment is essential for nursing practice in developing a culturally competent ICSG for Asian Americans. Also, emotional familiarity should be incorporated into the design of the ICSG, and the ICSG needs to be based on non-judgmental and non-discriminative interactions. PMID:20357657

  18. 32 CFR 644.168 - Exercise of options.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Exercise of options. 644.168 Section 644.168... Exercise of options. Upon issuance of a real estate directive for acquisition of the optioned real property, the District or Division Engineer will exercise the option and proceed with the acquisition...

  19. 32 CFR 644.168 - Exercise of options.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Exercise of options. 644.168 Section 644.168... Exercise of options. Upon issuance of a real estate directive for acquisition of the optioned real property, the District or Division Engineer will exercise the option and proceed with the acquisition...

  20. 32 CFR 644.168 - Exercise of options.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Exercise of options. 644.168 Section 644.168... Exercise of options. Upon issuance of a real estate directive for acquisition of the optioned real property, the District or Division Engineer will exercise the option and proceed with the acquisition...

  1. 32 CFR 644.168 - Exercise of options.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Exercise of options. 644.168 Section 644.168... Exercise of options. Upon issuance of a real estate directive for acquisition of the optioned real property, the District or Division Engineer will exercise the option and proceed with the acquisition...

  2. 32 CFR 644.168 - Exercise of options.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Exercise of options. 644.168 Section 644.168... Exercise of options. Upon issuance of a real estate directive for acquisition of the optioned real property, the District or Division Engineer will exercise the option and proceed with the acquisition...

  3. Career options.

    PubMed

    2011-06-24

    Practitioners at all levels can plan their future career options through the NHS Nursing Career Framework interactive tool. The tool builds on the pathway-based framework set out in the post-registration career framework for nurses. Career pathways are outlined under each branch and the specialties within the branches, and cover topics including clinical careers, management and moving into education or research.

  4. Exercising options

    NASA Astrophysics Data System (ADS)

    Carlowicz, Michael

    In a recent speech to graduates of the College of Computer, Mathematical, and Physical Sciences at the University of Maryland, Anne Petersen, deputy director of the National Science Foundation, encouraged a new generation of scientists to embrace opportunity and choice, and to use their scientific training as an employment credential, not a limit. In her May 23 commencement address, Petersen exhorted students to view their freshly minted diplomas as tickets to a broad and diverse job market, not just one-way trips to the laboratory.“Looking for the options and alternatives open to us—and creating options for ourselves where they are not apparent—can give us a sense of direction and volition that enriches our lives immensely…

  5. Multi-Perspective Indexing of Diverse Spatial Characteristics of an Outdoor Field toward Redesigning of Real-World Learning

    ERIC Educational Resources Information Center

    Okada, Masaya; Tada, Masahiro

    2014-01-01

    Real-world learning is important because it encourages learners to obtain knowledge through various experiences. To design effective real-world learning, it is necessary to analyze the diverse learning activities that occur in real-world learning and to develop effective strategies for learning support. By inventing the technologies of multimodal…

  6. Multi-Perspective Indexing of Diverse Spatial Characteristics of an Outdoor Field toward Redesigning of Real-World Learning

    ERIC Educational Resources Information Center

    Okada, Masaya; Tada, Masahiro

    2014-01-01

    Real-world learning is important because it encourages learners to obtain knowledge through various experiences. To design effective real-world learning, it is necessary to analyze the diverse learning activities that occur in real-world learning and to develop effective strategies for learning support. By inventing the technologies of multimodal…

  7. Perspectives.

    ERIC Educational Resources Information Center

    Robertson, Shari; Camerini, Michael

    2001-01-01

    Provides background information on the U.S. Immigration and Naturalization Service Asylum office. Uses the perspective of two movie producers as they filmed a documentary film, "Well-founded Fear", about asylum and refugee protection. Includes information on how to order a classroom aid and the film. (CMK)

  8. Perspectives

    ERIC Educational Resources Information Center

    Tarone, Elaine

    2013-01-01

    The topic of this "Perspectives" column is "Requiring a Proficiency Level as a Requirement for U.S. K-12 Teacher Licensure." In 1998, the American Council of Teachers of Foreign Languages (ACTFL) began to work with the National Council for Accreditation of Teacher Education (NCATE), which accredits teacher education programs…

  9. Perspectives

    ERIC Educational Resources Information Center

    Tarone, Elaine

    2013-01-01

    The topic of this "Perspectives" column is "Requiring a Proficiency Level as a Requirement for U.S. K-12 Teacher Licensure." In 1998, the American Council of Teachers of Foreign Languages (ACTFL) began to work with the National Council for Accreditation of Teacher Education (NCATE), which accredits teacher education programs…

  10. Novel operative treatment options.

    PubMed

    Ricketts, D N J; Pitts, N B

    2009-01-01

    There are an increasing number of more novel options available for operative intervention. This chapter outlines a series of operative treatment options which are available to the modern clinician to select from once a decision has been made to treat a carious lesion operatively. A series of novel methods of caries removal have been described; including chemomechanical caries removal, air abrasion, sono-abrasion, polymer rotary burs and lasers. There are also novel approaches to ensure complete caries removal and novel approaches for the management of deep caries. A novel question increasingly asked by clinicians is: does all the caries need to be removed? Operative management options here include: therapeutic fissure sealants, ultraconservative caries removal, stepwise excavation and the Hall technique. In conclusion, there is now a growing wealth of evidence that questions the traditional methods of caries removal and restoring the tooth. In parallel, there is a growing movement exploring the merits of therapeutically sealing caries into the tooth. This philosophy is alien to many of today's dentists and, until further randomized controlled trials are carried out in primary care, prudent caution must be exercised with this promising approach. Research is required into techniques which will allow monitoring of sealed caries to detect any rare, but insidious, failures. These novel techniques are an alternative way of managing the later stages of the caries process from a sounder biological basis and have marked potential benefits to patients from treatment, pain and outcome perspectives. Copyright 2009 S. Karger AG, Basel

  11. "It's a Hard Line to Walk": Black Non-Binary Trans* Collegians' Perspectives on Passing, Realness, and Trans*-Normativity

    ERIC Educational Resources Information Center

    Nicolazzo, Z.

    2016-01-01

    Being labeled as "abnormal, or deviant, or not being one of the rest of us" has real effects for one's life chances. Trans* people are one such group who have continually been codified as abnormal, abject, weird, deceptive, and social pariahs. The purpose of the following study was to explore how the concepts of passing, realness, and…

  12. "It's a Hard Line to Walk": Black Non-Binary Trans* Collegians' Perspectives on Passing, Realness, and Trans*-Normativity

    ERIC Educational Resources Information Center

    Nicolazzo, Z.

    2016-01-01

    Being labeled as "abnormal, or deviant, or not being one of the rest of us" has real effects for one's life chances. Trans* people are one such group who have continually been codified as abnormal, abject, weird, deceptive, and social pariahs. The purpose of the following study was to explore how the concepts of passing, realness, and…

  13. Mind the gap: Learners' perspectives on what they learn in communication compared to how they and others behave in the real world.

    PubMed

    Malhotra, Aneil; Gregory, Ian; Darvill, Emily; Goble, Edward; Pryce-Roberts, Adele; Lundberg, Kristina; Konradsen, Steinar; Hafstad, Heidi

    2009-09-01

    To explore the lack of the learners' voice at previous international conferences on communication in healthcare. A group of medical students and recently qualified junior doctors were invited to give the learner's perspective on how communication skills are taught and how they are implemented in 'real life', at a 90min symposium at the EACH International Conference on Communication in Healthcare, 4th September 2008, Oslo. We attempt to bridge the gap between learning communication skills formally in the medical classroom and actually implementing these in the real world between doctors and patients from a learners' perspective. In making this transition we highlight obvious weaknesses and potential pitfalls, whilst also drawing attention to the successful strategies used in our respective medical schools. Four key areas are discussed: (1) using simulated patients, (2) learning in the clinical setting, (3) barriers to utilizing communication skills, (4) future directions. We have drawn upon the learning experiences from both undergraduate and postgraduate environments in the UK, the USA and Norway. Our experiences differed between universities from the same country, which widened across continents. The differences between how we behave in the classroom and how we are with real patients when unobserved have been highlighted; and we have attempted to explain why trainees sometimes modify their behavior in medical assessments with standardized patients for examinations as opposed to how we would perform on wards or in general practice. The teaching of communication skills will continue to develop over the forthcoming years. Integrating communication skills into medical school curricula is essential. Identifying enthusiastic doctors who are effective communicators and have the initiative to help develop this is vital. It may be beneficial to train simulated patients to react to students in a variety of different ways to reflect the diversity of true patient responses

  14. Mixed waste management options

    SciTech Connect

    Owens, C.B.; Kirner, N.P.

    1991-12-31

    Disposal fees for mixed waste at proposed commercial disposal sites have been estimated to be $15,000 to $40,000 per cubit foot. If such high disposal fees are imposed, generators may be willing to apply extraordinary treatment or regulatory approaches to properly dispose of their mixed waste. This paper explores the feasibility of several waste management scenarios and attempts to answer the question: Can mixed waste be managed out of existence? Existing data on commercially generated mixed waste streams are used to identify the realm of mixed waste known to be generated. Each waste stream is evaluated from both a regulatory and technical perspective in order to convert the waste into a strictly low-level radioactive or a hazardous waste. Alternative regulatory approaches evaluated in this paper include a delisting petition, no migration petition, and a treatability variance. For each waste stream, potentially available treatment options are identified that could lead to these variances. Waste minimization methodology and storage for decay are also considered. Economic feasibility of each option is discussed broadly.

  15. Treatment Options for Age-Related Macular Degeneration: A Budget Impact Analysis from the Perspective of the Brazilian Public Health System

    PubMed Central

    Elias, Flávia Tavares Silva; da Silva, Everton Nunes; Belfort, Rubens; Silva, Marcus Tolentino; Atallah, Álvaro Nagib

    2015-01-01

    Background Age-related macular degeneration (AMD) is a disease that causes reduced visual acuity and blindness. The new treatment options for AMD are not provided by the Brazilian public health system. Objective To conduct a budget impact analysis of three scenarios for the introduction of AMD treatments: all the medications (verteporfin, ranibizumab, and bevacizumab–the reference scenario), ranibizumab alone, and bevacizumab alone. Methods The basic assumption was that the Brazilian public health system would treat the entire target population with AMD aged > 70 years between 2008 and 2011. The size of the population of interest was estimated from official population projections and the prevalence of the disease was obtained from a systematic review. Medication prices were estimated by weighting their market values with correction factors to take account of the public procurement policy. The possibility of aliquoting bevacizumab was also considered. A panel of experts was consulted to estimate the market share of the different medications for the reference scenario. The incremental costs of the ranibizumab-alone and bevacizumab-alone scenarios compared to the reference scenario were calculated. Univariate sensitivity analyses were run to check the robustness of the model. Results In four years, the Brazilian public health system would have treated 1,136,349 individuals with AMD. The annual costs of treating one patient would have been US$476.65 for bevacizumab, US$11,469.39 for ranibizumab, and US$4,376.28 for verteporfin. The incremental cost of the ranibizumab-alone scenario would have been US$1,878,318,056.00 in four years, while the incremental cost for the bevacizumab-alone scenario would have been a reduction of US$4,978,326,359.00 (i.e., a cost saving) in the same period. The bevacizumab-alone option was found to represent a cost saving across sensitivity analyses. Conclusion The introduction of bevacizumab for the treatment of AMD is recommended for the

  16. Two barriers to realizing the benefits of biometrics: a chain perspective on biometrics and identity fraud as biometrics' real challenge

    NASA Astrophysics Data System (ADS)

    Grijpink, Jan

    2004-06-01

    Along at least twelve dimensions biometric systems might vary. We need to exploit this variety to manoeuvre biometrics into place to be able to realise its social potential. Subsequently, two perspectives on biometrics are proposed revealing that biometrics will probably be ineffective in combating identity fraud, organised crime and terrorism: (1) the value chain perspective explains the first barrier: our strong preference for large scale biometric systems for general compulsory use. These biometric systems cause successful infringements to spread unnoticed. A biometric system will only function adequately if biometrics is indispensable for solving the dominant chain problem. Multi-chain use of biometrics takes it beyond the boundaries of good manageability. (2) the identity fraud perspective exposes the second barrier: our traditional approach to identity verification. We focus on identity documents, neglecting the person and the situation involved. Moreover, western legal cultures have made identity verification procedures known, transparent, uniform and predictable. Thus, we have developed a blind spot to identity fraud. Biometrics provides good potential to better checking persons, but will probably be used to enhance identity documents. Biometrics will only pay off if it confronts the identity fraudster with less predictable verification processes and more risks of his identity fraud being spotted. Standardised large scale applications of biometrics for general compulsory use without countervailing measures will probably produce the reverse. This contribution tentatively presents a few headlines for an overall biometrics strategy that could better resist identity fraud.

  17. Patients' Perspectives on Wait Times and the Referral-Consultation Process While Attending a Tertiary Diabetes and Endocrinology Centre: Is Econsultation an Acceptable Option?

    PubMed

    Keely, Erin; Traczyk, Lara; Liddy, Clare

    2015-08-01

    The goal of this study was to establish patients' perspectives on the acceptability of wait times, the impact of wait times on their health and the possibility of using electronic consultations (eConsultations) to avoid visits to specialists. A 2-stage patient survey (self-administered and with a follow-up telephone call) and a chart audit was conducted on a sequential sample of patients attending their initial consultations in a tertiary diabetes and endocrinology centre. Patients' perspectives on actual and ideal wait times, the impact of waiting for access, the effectiveness of the referral-consultation process and attitudes toward eConsultations as an alternative to traditional referral-consultations were collected. The study involved 101 patients (22% for diabetes, 78% for endocrinologic conditions), whose comments were collated and categorized. Of the 101 patients who completed the survey, 61 also completed telephone interviews. The average wait time was 19 weeks; the median 10 weeks. More than 30% of patients waited longer than 6 months and 6% waited longer than 1 year. Overall, 90% of patients thought that the maximum wait time should be less than 3 months. While waiting, 58% of patients worried about a serious undiagnosed disease, 30% found their symptoms had affected their daily activities and 24% had to miss work or school due to symptoms. Of the patients, 46% considered eConsultation a viable alternative to face-to-face visits. Excessive wait times for specialist care remain barriers and have negative impacts on patients. Wait times significantly exceeded times patients considered acceptable. eConsultations provide acceptable alternatives for many patients, and they reduced the number of patients requiring traditional consultations. Copyright © 2015 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  18. Clinician Perspectives of Diagnosis and Perceived Client Change in "Real World" Psychotherapy for Youth Emotional and Behavioral Disorders

    ERIC Educational Resources Information Center

    Haine, Rachel A.; Brookman-Frazee, Lauren; Tsai, Katherine H.; Roesch, Scott C.; Garland, Ann F.

    2007-01-01

    We investigated the extent to which clinician-assigned diagnoses of emotional and behavioral disorders and clinicians' perceptions of client change are consistent with structured measures of youth clinical functioning and parent/family characteristics within the context of usual care or "real world" psychotherapy. A total of 54 therapists from two…

  19. Hypertension Attitude PersPEctives and Needs (HAPPEN): A Real-World Survey of Physicians and Patients With Hypertension in China.

    PubMed

    Feldman, Ross D; Liu, Lisheng; Wu, Zhaosu; Zhang, Yuqing; Yu, Xueqing; Zhang, Xin-Hua

    2017-03-01

    The Hypertension Attitude PersPEctives and Needs (HAPPEN) survey was a real-world survey of cardiologists, nephrologists, and patients with treated hypertension at level 3 hospitals in China. It aimed to characterize the attitudes and behavior of physicians and patients and to identify possible causes of poor blood pressure (BP) control. Randomly selected participants (100 cardiologists, 30 nephrologists, 400 patients) completed face-to-face interviews investigating BP control rates, consulting behavior, prescribing patterns, and attitudes toward hypertension management. Perceived levels of BP control were high; 70% of physicians and 85% of patients believed that BP targets were achieved, despite only 31% of patients achieving targets. Physician satisfaction with control rates and patient satisfaction with treatment were high. Differences in perceived and actual levels of BP control may be driving therapeutic inertia. In combination with inadequate patient evaluation and support services, therapeutic inertia may contribute to poor BP control among patients with treated hypertension in China.

  20. 41 CFR 102-73.130 - When may Federal agencies consider acquiring leases with purchase options?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATION REAL PROPERTY 73-REAL ESTATE ACQUISITION Acquisition by Lease Leases with Purchase Options § 102... consider leasing with a purchase option at or below fair market value, consistent with the...

  1. "I always viewed this as the real psychiatry": provider perspectives on community psychiatry as a career of first choice.

    PubMed

    Carpenter-Song, Elizabeth; Torrey, William C

    2015-04-01

    The US needs engaged and skilled psychiatrists to support the recovery of people with severe mental illnesses and we are currently facing a shortage. This paper examines what attracts providers to community psychiatry and what sustains them in their work. Focus groups and interviews were used to elicit the perspectives of prescribing clinicians in three community mental health clinics in the US. Community psychiatry has inherent challenges, including facing high-risk decisions, encountering intense affects, and occasionally witnessing bad outcomes. Psychiatrists are motivated and sustained in this work by (1) cultivating relationships with patients and colleagues, (2) focusing on the mission of promoting recovery, and (3) engaging with clinical practice as intellectually stimulating work. Administrators support the engagement and morale of psychiatrists by creating workflows that allow psychiatrists to meaningfully apply their expertise to support patients' recovery. These findings hold implications for recruiting and retaining a new generation of physicians.

  2. Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy

    NASA Astrophysics Data System (ADS)

    Pablico-Lansigan, Michele H.; Situ, Shu F.; Samia, Anna Cristina S.

    2013-05-01

    Magnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of MPI is envisioned to transcend those of other medical imaging modalities presently used, such as magnetic resonance imaging (MRI), X-ray scans, ultrasound, computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT). In this review, we present an overview of the recent advances in the rapidly developing field of MPI. We begin with a basic introduction of the fundamentals of MPI, followed by some highlights over the past decade of the evolution of strategies and approaches used to improve this new imaging technique. We also examine the optimization of iron oxide nanoparticle tracers used for imaging, underscoring the importance of size homogeneity and surface engineering. Finally, we present some future research directions for MPI, emphasizing the novel and exciting opportunities that it offers as an important tool for real-time in vivo monitoring. All these opportunities and capabilities that MPI presents are now seen as potential breakthrough innovations in timely disease diagnosis, implant monitoring, and image-guided therapeutics.

  3. Offshore pollution monitoring using fully polarimetric X- and C-band synthetic aperture radar: a near-real-time perspective

    NASA Astrophysics Data System (ADS)

    Singha, Suman; Ressel, Rudolf; Lehner, Susanne

    2016-05-01

    Use of polarimetric features for oil spill characterization is relatively new and have not been used for operational services until now. In the last decade, a number of semi-automatic and automatic techniques have been proposed in order to differentiate oil spill and look-alike spots based on single pol SAR data, however these techniques suffer from a high miss-classification rate which is undesirable for operational services. In addition to that, small operational spillages from offshore platforms are often ignored as it appears insignificant on traditional ScanSAR (wide) images. In order to mitigate this situation a major focus of research in this area is the development of automated algorithms based on polarimetric images to distinguish oil spills from look-alikes. This paper describes the development of an automated Near Real Time (NRT) oil spill detection processing chain based on quad-pol RADARSAT-2 and quad-pol TerraSAR-X images using polarimetric features (e.g. Lexicographic and Pauli Based features). Number TerraSAR-X images acquired over known offshore platforms with same day ascending and descending configuration along with near coincident RADARSAT-2 acquisition. A total number of 10 polarimetric feature parameters were extracted from different types of oil (e.g. crude oil, emulsion etc) and look-alike spots and divided into training and validation dataset. Extracted features were then used for training and validation of a pixel based Artificial Neural Network (ANN) classifier. Initial performance estimation was carried out for the proposed methodology in order to evaluate its suitability for NRT operational service. Mutual information contents among extracted features were assessed and feature parameters were ranked according to their ability to discriminate between oil spill and look- alike. Polarimetric features such as Scattering diversity, Surface scattering fraction, Entropy and Span proved to be more discriminative than other polarimetric features.

  4. Breast Cancer: Treatment Options

    MedlinePlus

    ... Breast Cancer > Breast Cancer: Treatment Options Request Permissions Breast Cancer: Treatment Options Approved by the Cancer.Net Editorial ... recommendations for ovarian ablation . Hormonal therapy for metastatic breast cancer Hormonal therapies are also commonly used to treat ...

  5. Achondroplasia: Current Options and Future Perspective.

    PubMed

    Bouali, Houda; Latrech, Hanane

    2015-06-01

    Achondroplasia is a human bone genetic disorder of the growth plate and is the most common form of inherited disproportionate short stature. It is inherited as an autosomal dominant disease with essentially complete penetrance. Of these most have the same point mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) which is a negative regulator of bone growth. The clinical and radiological features of achondroplasia can easily be identified; they include disproportionate short stature with rhizomelic shortening, macrocephaly with frontal bossing, midface hypoplasia, lumbar hyperlordosis, and a trident hand configuration. The majority of achondroplasts have a normal intelligence, but many social and medical complications may compromise a full and productive life. Some of them have serious health consequences related to hydrocephalus, craniocervical junction compression, or upper-airway obstruction. In this article, we discuss a number of treatments from the surgical limb lengthening approach and the Recombinant Growth Hormone (rhGH) treatment, to future treatments, which include the Natriuretic Peptide C-type (CNP). The discussion is a comparative study of the complications and drawbacks of various experiments using numerous strategies.

  6. TANK SPACE OPTIONS REPORT

    SciTech Connect

    WILLIS WL; AHRENDT MR

    2009-08-11

    Since this report was originally issued in 2001, several options proposed for increasing double-shell tank (DST) storage space were implemented or are in the process of implementation. Changes to the single-shell tank (SST) waste retrieval schedule, completion of DST space saving options, and the DST space saving options in progress have delayed the projected shortfall of DST storage space from the 2007-2011 to the 2018-2025 timeframe (ORP-11242, River Protection Project System Plan). This report reevaluates options from Rev. 0 and includes evaluations of new options for alleviating projected restrictions on SST waste retrieval beginning in 2018 because of the lack of DST storage space.

  7. The IRIS DMC: Perspectives on Real-Time Data Management and Open Access From a Large Seismological Archive: Challenges, Tools, and Quality Assurance

    NASA Astrophysics Data System (ADS)

    Benson, R. B.

    2007-05-01

    The IRIS Data Management Center, located in Seattle, WA, is the largest openly accessible geophysical archive in the world, and has a unique perspective on data management and operational practices that gets the most out of your network. Networks scale broad domains in time and space, from finite needs to monitor bridges and dams to national and international networks like the GSN and the FDSN that establish a baseline for global monitoring and research, the requirements that go into creating a well-tuned DMC archive treat these the same, building a collaborative network of networks that generations of users rely on and adds value to the data. Funded by the National Science Foundation through the Division of Earth Sciences, IRIS is operated through member universities and in cooperation with the USGS, and the DMS facility is a bridge between a globally distributed collaboration of seismic networks and an equally distributed network of users that demand a high standard for data quality, completeness, and ease of access. I will describe the role that a perpetual archive has in the life cycle of data, and how hosting real-time data performs a dual role of being a hub for continuous data from approximately 59 real-time networks, and distributing these (along with other data from the 40-year library of available time-series data) to researchers, while simultaneously providing shared data back to networks in real- time that benefits monitoring activities. I will describe aspects of our quality-assurance framework that are both passively and actively performed on 1100 seismic stations, generating over 6,000 channels of regularly sampled data arriving daily, that data providers can use as aids in operating their network, and users can likewise use when requesting suitable data for research purposes. The goal of the DMC is to eliminate bottlenecks in data discovery and shortening the steps leading to analysis. This includes many challenges, including keeping metadata

  8. Approximate option pricing

    SciTech Connect

    Chalasani, P.; Saias, I.; Jha, S.

    1996-04-08

    As increasingly large volumes of sophisticated options (called derivative securities) are traded in world financial markets, determining a fair price for these options has become an important and difficult computational problem. Many valuation codes use the binomial pricing model, in which the stock price is driven by a random walk. In this model, the value of an n-period option on a stock is the expected time-discounted value of the future cash flow on an n-period stock price path. Path-dependent options are particularly difficult to value since the future cash flow depends on the entire stock price path rather than on just the final stock price. Currently such options are approximately priced by Monte carlo methods with error bounds that hold only with high probability and which are reduced by increasing the number of simulation runs. In this paper the authors show that pricing an arbitrary path-dependent option is {number_sign}-P hard. They show that certain types f path-dependent options can be valued exactly in polynomial time. Asian options are path-dependent options that are particularly hard to price, and for these they design deterministic polynomial-time approximate algorithms. They show that the value of a perpetual American put option (which can be computed in constant time) is in many cases a good approximation to the value of an otherwise identical n-period American put option. In contrast to Monte Carlo methods, the algorithms have guaranteed error bounds that are polynormally small (and in some cases exponentially small) in the maturity n. For the error analysis they derive large-deviation results for random walks that may be of independent interest.

  9. The Origins of Options

    PubMed Central

    Smaldino, Paul E.; Richerson, Peter J.

    2012-01-01

    Most research on decision making has focused on how human or animal decision makers choose between two or more options, posed in advance by the researchers. The mechanisms by which options are generated for most decisions, however, are not well understood. Models of sequential search have examined the trade-off between continued exploration and choosing one’s current best option, but still cannot explain the processes by which new options are generated. We argue that understanding the origins of options is a crucial but untapped area for decision making research. We explore a number of factors which influence the generation of options, which fall broadly into two categories: psycho-biological and socio-cultural. The former category includes factors such as perceptual biases and associative memory networks. The latter category relies on the incredible human capacity for culture and social learning, which doubtless shape not only our choices but the options available for choice. Our intention is to start a discussion that brings us closer toward understanding the origins of options. PMID:22514515

  10. 47 CFR 1.2103 - Competitive bidding design options.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Competitive bidding design options. 1.2103... design options. (a) The Commission will choose from one or more of the following types of auction designs...) The Commission may use real time bidding in all electronic auction designs. ...

  11. Life Options Rehabilitation Program

    MedlinePlus

    ... at our CE credit website . Free Life Options Materials Download our free print materials, research-based fact ... sheets are also available in Spanish! Vaccination Education Materials Easy-to-read patient education fact sheets will ...

  12. Other Remedy Options Evaluated

    EPA Pesticide Factsheets

    EPA considered several remedy options for reducing emissions from electric generating units (EGUs) that contribute significantly to nonattainment or interfere with maintenance of the air quality standards by downwind states.

  13. Options for fuel management

    SciTech Connect

    Reardon, L.D. Jr.; Chance, R.C.

    1996-12-31

    The key to cofiring wood or other biomass with coal in existing power stations is fuel management. Fuel management includes the procurement, receiving, processing, storage, and blending of the biomass with coal. Procurement options may include the purchase of lower cost biomass fuels, receipt of subsidies to make capital modifications to cofire biomass {open_quotes}waste{close_quotes} fuels or receive tipping fees where biomass waste disposal options for a particular area are expensive. Biomass receiving options include delivery methods, unloading, measurement, and inspection. Processing options are associated with screen types, drying systems, final particle size required, and associated questions of fuel supply reliability. Issues include the ability of the coal yard to accept this processing operation, handling convenience, traffic patterns, staffing requirements, and ultimately the cost of fuel at the burner. Issues associated with storage include locating the facility, managing dust, managing moisture pick-up, and managing runoff. Blending options include pre-blending or designing a system to blend the fuels as they are transported from the coal yard to the bunkers. This paper reviews the major decisions that have to be made, and discusses some of the options available. It draws upon existing experience in cofiring systems to achieve a low cost, high reliability system to use biomass at coal-fired electricity generating stations.

  14. Nevada Transportatoion Options Study

    SciTech Connect

    P. GEHNER; E.M. WEAVER; L. FOSSUM

    2006-05-25

    This study performs a cost and schedule analysis of three Nevada Transportation options that support waste receipt at the repository. Based on the U.S. Department of Energy preference for rail transportation in Nevada (given in the Final Environmental Impact Statement), it has been assumed that a branch rail line would be constructed to support waste receipt at the repository. However, due to potential funding constraints, it is uncertain when rail will be available. The three Nevada Transportation options have been developed to meet a varying degree of requirements for transportation and to provide cost variations used in meeting the funding constraints given in the Technical Direction Letter guidelines for this study. The options include combinations of legal-weight truck, heavy-haul truck, and rail. Option 1 uses a branch rail line that would support initial waste receipt at the repository in 2010. Rail transportation would be the primary mode, supplemented by legal weight trucks. This option provides the highest level of confidence in cost and schedule, lowest public visibility, greatest public acceptability, lowest public dose, and is the recommended option for support of waste receipt. The completion of rail by 2010 will require spending approximately $800 million prior to 2010. Option 2 uses a phased rail approach to address a constrained funding scenario. To meet funding constraints, Option 2 uses a phased approach to delay high cost activities (final design and construction) until after initial waste receipt in 2010. By doing this, approximately 95 percent of the cost associated with completion of a branch rail line is deferred until after 2010. To support waste receipt until a branch rail line is constructed in Nevada, additional legal-weight truck shipments and heavy-haul truck shipments (on a limited basis for naval spent nuclear fuel) would be used to meet the same initial waste receipt rates as in Option 1. Use of heavy-haul shipments in the absence

  15. Options Study - Phase II

    SciTech Connect

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  16. Towards the Real-Time Evaluation of Collaborative Activities: Integration of an Automatic Rater of Collaboration Quality in the Classroom from the Teacher's Perspective

    ERIC Educational Resources Information Center

    Chounta, Irene-Angelica; Avouris, Nikolaos

    2016-01-01

    This paper presents the integration of a real time evaluation method of collaboration quality in a monitoring application that supports teachers in class orchestration. The method is implemented as an automatic rater of collaboration quality and studied in a real time scenario of use. We argue that automatic and semi-automatic methods which…

  17. Towards the Real-Time Evaluation of Collaborative Activities: Integration of an Automatic Rater of Collaboration Quality in the Classroom from the Teacher's Perspective

    ERIC Educational Resources Information Center

    Chounta, Irene-Angelica; Avouris, Nikolaos

    2016-01-01

    This paper presents the integration of a real time evaluation method of collaboration quality in a monitoring application that supports teachers in class orchestration. The method is implemented as an automatic rater of collaboration quality and studied in a real time scenario of use. We argue that automatic and semi-automatic methods which…

  18. Real Earthquakes, Real Learning

    ERIC Educational Resources Information Center

    Schomburg, Aaron

    2003-01-01

    One teacher took her class on a year long earthquake expedition. The goal was to monitor the occurrences of real earthquakes during the year and mark their locations with push pins on a wall-sized world map in the hallway outside the science room. The purpose of the project was to create a detailed picture of the earthquakes that occurred…

  19. Real Earthquakes, Real Learning

    ERIC Educational Resources Information Center

    Schomburg, Aaron

    2003-01-01

    One teacher took her class on a year long earthquake expedition. The goal was to monitor the occurrences of real earthquakes during the year and mark their locations with push pins on a wall-sized world map in the hallway outside the science room. The purpose of the project was to create a detailed picture of the earthquakes that occurred…

  20. 20 CFR 416.2035 - Optional supplementation: Additional State options.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Optional supplementation: Additional State options. 416.2035 Section 416.2035 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... § 416.2035 Optional supplementation: Additional State options. (a) Residency requirement. A State...

  1. 20 CFR 416.2035 - Optional supplementation: Additional State options.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Optional supplementation: Additional State options. 416.2035 Section 416.2035 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... § 416.2035 Optional supplementation: Additional State options. (a) Residency requirement. A State...

  2. 20 CFR 416.2035 - Optional supplementation: Additional State options.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Optional supplementation: Additional State options. 416.2035 Section 416.2035 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... § 416.2035 Optional supplementation: Additional State options. (a) Residency requirement. A State...

  3. 20 CFR 416.2035 - Optional supplementation: Additional State options.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Optional supplementation: Additional State options. 416.2035 Section 416.2035 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... § 416.2035 Optional supplementation: Additional State options. (a) Residency requirement. A State...

  4. 20 CFR 416.2035 - Optional supplementation: Additional State options.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Optional supplementation: Additional State options. 416.2035 Section 416.2035 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... § 416.2035 Optional supplementation: Additional State options. (a) Residency requirement. A State...

  5. Fluorosis varied treatment options

    PubMed Central

    Sherwood, I Anand

    2010-01-01

    Fluorosis has been reported way back in 1901. The treatment options for fluorosis are varied depending upon individual cases. This article comes from Madurai in India where its surrounding towns are fluorosis-prone zones. The purpose of this article is to report various treatment options available for dental fluorosis; this is the first time that complete full mouth rehabilitation for dental fluorosis is being reported. This article also dwells on the need for the dentists to be aware of their local indigenous pathologies to treat it in a better manner. PMID:20582220

  6. Thermal test options

    SciTech Connect

    Koski, J.A.; Keltner, N.R.; Sobolik, K.B.

    1993-02-01

    Shipping containers for radioactive materials must be qualified to meet a thermal accident environment specified in regulations, such at Title 10, Code of Federal Regulations, Part 71. Aimed primarily at the shipping container design, this report discusses the thermal testing options available for meeting the regulatory requirements, and states the advantages and disadvantages of each approach. The principal options considered are testing with radiant heat, furnaces, and open pool fires. The report also identifies some of the facilities available and current contacts. Finally, the report makes some recommendations on the appropriate use of these different testing methods.

  7. The hydrogen hybrid option

    SciTech Connect

    Smith, J.R.

    1993-10-15

    The energy efficiency of various piston engine options for series hybrid automobiles are compared with conventional, battery powered electric, and proton exchange membrane (PEM) fuel cell hybrid automobiles. Gasoline, compressed natural gas (CNG), and hydrogen are considered for these hybrids. The engine and fuel comparisons are done on a basis of equal vehicle weight, drag, and rolling resistance. The relative emissions of these various fueled vehicle options are also presented. It is concluded that a highly optimized, hydrogen fueled, piston engine, series electric hybrid automobile will have efficiency comparable to a similar fuel cell hybrid automobile and will have fewer total emissions than the battery powered vehicle, even without a catalyst.

  8. Lighting Options for Homes.

    SciTech Connect

    Baker, W.S.

    1991-04-01

    This report covers many aspects of various lighting options for homes. Types of light sources described include natural light, artificial light, incandescent lamps, fluorescent lamps, and high intensity discharge lamps. A light source selection guide gives the physical characteristics of these, design considerations, and common applications. Color, strategies for efficient lighting, and types of lighting are discussed. There is one section giving tips for various situations in specific rooms. Rooms and types of fixtures are shown on a matrix with watts saved by using the recommended type lighting for that room and room location. A major emphasis of this report is saving energy by utilizing the most suitable, recommended lighting option. (BN)

  9. Exploring Career Options.

    ERIC Educational Resources Information Center

    Hellerman, Susan B., Ed.

    1994-01-01

    This newsletter theme issue offers advice to academically talented youth on exploring career options. It begins with an article titled "How To Think about Your Career When You Haven't Even Decided Where To Go to College." The article notes the hazards of early career choice and recognizes the career indecision often brought on by…

  10. Option Y, Statistics.

    ERIC Educational Resources Information Center

    Singer, Arlene

    This guide outlines a one semester Option Y course, which has seven learner objectives. The course is designed to provide students with an introduction to the concerns and methods of statistics, and to equip them to deal with the many statistical matters of importance to society. Topics covered include graphs and charts, collection and…

  11. CFB repowering options

    SciTech Connect

    Gittinger, J.

    1996-12-31

    Circulating fluidized bed CFB repowering options are summarized. The following topics are discussed: why repower with CFB technology; advantages of repowering; two forms of of repowering; B and N`s internal recirculation CFB; space-saving design features; cost-saving design features; Ukrainian repowering project; and candidates for repowering.

  12. Oregon Early Options Study.

    ERIC Educational Resources Information Center

    Oregon Univ. System, Eugene. Office of Academic Affairs.

    This report examines current policies and practices in regard to Oregon high school student participation in college courses and programs. A total of 112 of Oregon's public and private high schools responded to a January 1998 mailed survey concerning early college options programs and policies. It was found that an estimated 6,660 students were…

  13. ARSENIC TREATMENT OPTIONS

    EPA Science Inventory

    The PPT presentation will provide information on the drinking water treatment options for small utilities to remove arsenic from ground water. The discussion will include information on the EPA BAT listed processes and on some of the newer technologies, such as the iron based ad...

  14. Our Energy Options.

    ERIC Educational Resources Information Center

    Meyers, Paul A.; Witt, Frank C.

    Presented is an analysis of alternatives available to the United States in dealing with energy problems. Options explained and evaluated include coal, solar, hydroelectric, nuclear, geothermal, wind, biomass, and energy conservation. The booklet is part of Project APEC (America's Possible Energy Choices), a nationally validated Title IVc project…

  15. Career Options in Chemistry.

    ERIC Educational Resources Information Center

    Belloli, Robert C.

    1985-01-01

    Describes a credit/no credit course which focuses on career options in chemistry. The course (consisting of 15 one-hour seminar-type sessions) includes guest speakers for several sessions and an emphasis (in introductory sessions) on graduate school in chemistry, the chemical industry, resumes, and interviews. Also briefly describes an internship…

  16. Treatment Options in Psoriasis

    PubMed Central

    Dantow, James E.

    1992-01-01

    Psoriasis is a common skin disease with a variety of clinical presentations. Fortunately, many treatment options are available to the patient and to the physician. Topical, systemic, and physical therapies can be tailored to the patient's needs. Patient compliance and a knowledgeable, caring physician are vital to successful control of the disease. Continuing research offers hope for the chronically disabled. PMID:21221381

  17. Alternative Education Options.

    ERIC Educational Resources Information Center

    Little (Arthur D.), Inc., Washington, DC.

    This guide deals with various areas of alternative education programs, including current practices and different options available to school and community personnel. Steps are outlined to assess present educational settings, design new programs, select the participants, and implement and evaluate the new program. The first appendix contains…

  18. Idaho's Energy Options

    SciTech Connect

    Robert M. Neilson

    2006-03-01

    This report, developed by the Idaho National Laboratory, is provided as an introduction to and an update of the status of technologies for the generation and use of energy. Its purpose is to provide information useful for identifying and evaluating Idaho’s energy options, and for developing and implementing Idaho’s energy direction and policies.

  19. New Options, Old Concerns.

    ERIC Educational Resources Information Center

    O'Neil, John

    1996-01-01

    Will greater school choice result in more responsive, higher quality schools and happier parents? Or will proliferating options further sort students and families by race, social class, and special interest? Increasingly, education is viewed as a private good. If parents become autonomous, self-interested consumers, erosion of common purposes and…

  20. A Menu of Options

    ERIC Educational Resources Information Center

    Joyner, Valerie

    2010-01-01

    Armed with a few topical and organizational strategies, primary grade teachers can successfully introduce their young scientists to science notebooks. The following overview of notebook methods offers a menu of options to help you develop creative and meaningful science notebook experiences. Choose and customize what works for your classroom to…

  1. Teletext: Assessing the Options.

    ERIC Educational Resources Information Center

    Carey, John; Nisenholtz, Martin

    1980-01-01

    This discussion of broadcast teletext explores some of the options available to public broadcasters and potential obstacles to implementing a teletext service. Topics covered include transmission alternatives, factors affecting service, design specifications, marketing possibilities, financial support, editorial control of information, standards…

  2. A systematic review and meta-analysis of the relative efficacy and safety of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimethoprim-sulfamethoxazole a real option?

    PubMed

    Hernandez, A V; Thota, P; Pellegrino, D; Pasupuleti, V; Benites-Zapata, V A; Deshpande, A; Penalva de Oliveira, A C; Vidal, J E

    2017-02-01

    The objective of this study was to perform a systematic review and meta-analysis of the literature to evaluate the efficacy and safety of therapies for cerebral toxoplasmosis in HIV-infected adults. The pyrimethamine plus sulfadiazine (P-S) combination is considered the mainstay therapy for cerebral toxoplasmosis and pyrimethamine plus clindamycin (P-C) is the most common alternative treatment. Although trimethoprim-sulfamethoxazole (TMP-SMX) has potential advantages, its use is infrequent. We searched PubMed and four other databases to identify randomized controlled trials (RCTs) and cohort studies. Two independent reviewers searched the databases, identified studies and extracted data. Risk ratios (RRs) were pooled across studies using random-effects models. Nine studies were included (five RCTs, three retrospective cohort studies and one prospective cohort study). In comparison to P-S, treatment with P-C or TMP-SMX was associated with similar rates of partial or complete clinical response [P-C: RR 0.87; 95% confidence interval (CI) 0.70-1.08; TMP-SMX: RR 0.97; 95% CI 0.78-1.21], radiological response (P-C: RR 0.92; 95% CI 0.82-1.03), skin rash (P-C: RR 0.81; 95% CI 0.56-1.17; TMP-SMX: RR 0.17; 95% CI 0.02-1.29), gastrointestinal impairment (P-C: RR 5.16; 95% CI 0.66-40.11), and drug discontinuation because of adverse events (P-C: RR 0.32; 95% CI 0.07-1.47). Liver impairment was more frequent with P-S than P-C (P-C vs. P-S: RR 0.48; 95% CI 0.24-0.97). The current evidence fails to identify a superior regimen in terms of relative efficacy or safety for the treatment of HIV-associated cerebral toxoplasmosis. Use of TMP-SMX as preferred treatment may be consistent with the available evidence and other real-world considerations. Larger comparative studies are needed. © 2016 British HIV Association.

  3. Options for the Future of the US National Strong-Motion Program

    USGS Publications Warehouse

    ,

    1997-01-01

    This report constitutes the requested 'Options Document'. This report considers three options. Option I assumes a constant level of financial support for Operating Expenses (OE) with not additional personnel support. Option II assumes a slight increase in OE support of $150K for FY 99 and beyond. Option III considers the role that a NSMP must play if the nation's urgent need to record the main earthquake at locations of significance for society is to be met. Two parts of Option III are considered. The first part of this option, termed Option III A, considers the role that strong-motion recording in and near man-made structures must play if a near-real time hazard initiative is to be implemented in the United States; The second part of Option III; termed Option III B, considers the scope of a NSMP needed to address society's needs to record the main earthquake in locations of significance for future public earthquake safety.

  4. Evaluating technology service options.

    PubMed

    Blumberg, D F

    1997-05-01

    Four service and support options are available to healthcare organizations for maintaining their growth arsenals of medical and information technology. These options include maintaining and servicing all equipment using a facility-based biomedical engineering and MIS service department; using a combination of facility-based service and subcontracted service; expanding facility-based biomedical and MIS service departments to provide service to other healthcare organizations to achieve economies of scale; and outsourcing all maintenance, repair, and technical support services. Independent service companies and original equipment manufacturers (OEMs) are offering healthcare organizations a wider array of service and support capabilities than ever before. However, some health systems have successfully developed their own independent service organizations to take care of their own--and other healthcare organizations'--service and support needs.

  5. Cooling options for Astromag

    NASA Technical Reports Server (NTRS)

    Maytal, B. Z.; Van Sciver, S. W.

    1992-01-01

    A comparison of the various cooling options for the Astromag particle physics experiment is presented. The baseline design for the cryogenic system involves using a natural circulation fountain-effect driven flow loop (Hofmann type). The present paper considers two alternative options for cooling. The first design involves a thermal strap made of a high-conductivity metal, e.g., high-purity aluminum or copper, which connects the coil to the helium reservoir. Venting helium vapor can also be used to minimize the temperature of the magnet and recover from a quench. The second design is based on an He II heat pipe concept where steady state heat transport is by counterflow. Cavitation is prevented by use of a porous plug. Forced flow He II is also available but only during extraordinary operating conditions.

  6. Osteoporosis: Therapeutic Options.

    PubMed

    Ivanova, Stefka; Vasileva, Liliya; Ivanova, Stanislava; Peikova, Lily; Obreshkova, Danka

    2015-01-01

    The definition of osteoporosis was originally formulated at a conference of the World Health Organization (WHO) in 1993 as 'a systemic skeletal disease characterized by decreased bone mass and altered micro-architecture of bone tissue, leading to enhanced bone fragility and risk of fractures'. Osteoporosis is characterized by low bone mineral density (BMD) and loss of the structural and bio-mechanical properties that are required to maintain bone homeostasis. This review aims to address the currently available options in prevention and treatment of osteoporosis. Management of osteoporosis includes non-pharmacological treatment - diet rich of calcium and vitamin D, healthy lifestyle, proper exercise plan, and pharmacological therapy. Combination of non-pharmacological and pharmacological treatment options have to be considered for prevention of osteoporosis and minimization of the risk of fractures. Given the heterogeneity of osteoporosis syndrome and lack of significant number of comparative studies, the choice of a pharmacological agents should be individualized.

  7. The safeguards options study

    SciTech Connect

    Hakkila, E.A.; Mullen, M.F.; Olinger, C.T.; Stanbro, W.D.; Olsen, A.P.; Roche, C.T.; Rudolph, R.R.; Bieber, A.M.; Lemley, J.; Filby, E.

    1995-04-01

    The Safeguards Options Study was initiated to aid the International Safeguards Division (ISD) of the DOE Office of Arms Control and Nonproliferation in developing its programs in enhanced international safeguards. The goal was to provide a technical basis for the ISD program in this area. The Safeguards Options Study has been a cooperative effort among ten organizations. These are Argonne National Laboratory, Brookhaven National Laboratory, Idaho National Engineering Laboratory, Lawrence Livermore National Laboratory, Los Alamos National Laboratory, Mound Laboratory, Oak Ridge National Laboratory, Pacific Northwest Laboratories, Sandia National Laboratories, and Special Technologies Laboratory. Much of the Motivation for the Safeguards Options Study is the recognition after the Iraq experience that there are deficiencies in the present approach to international safeguards. While under International Atomic Energy Agency (IAEA) safeguards at their declared facilities, Iraq was able to develop a significant weapons program without being noticed. This is because negotiated safeguards only applied at declared sites. Even so, their nuclear weapons program clearly conflicted with Iraq`s obligations under the Nuclear Nonproliferation Treaty (NPT) as a nonnuclear weapon state.

  8. Treatment options for osteoarthritis.

    PubMed

    Singh, Gurkirpal

    2003-01-01

    Osteoarthritis (OA) is a debilitating, degenerative disease of the articular cartilage and synovial fluid. Approximately 20 million Americans suffer from this disease for which no cure exists as yet. The primary goals of current OA therapy are centered on controlling pain; improving, preserving, or both, joint function and mobility; and improving health-related quality of life-but not on reversing the disease process. Current treatment options of OA consist of both non-pharmacological and pharmacological modalities. Non-pharmacological therapy that consists of patient education and physical/occupational therapy is a primary component of OA management, either rendered alone or in combination with pharmacological treatment. The several options for pharmacological treatment include acetaminophen, nonspecific NSAIDs, and COX-2 specific inhibitors. Many of these drugs, however, are beset with serious side effects. For patients with severe OA not responsive to medical treatment, nonsurgical interventions such as viscosupplements and injectable compounds that mimic healthy synovial fluid or surgical interventions are two likely options. The former, however, have not been shown unequivocally to be effective. Future treatment modalities for OA are geared toward reversing the disease process and may include disease-modifying drugs and gene therapy.

  9. Pectus excavatum: history, hypotheses and treatment options.

    PubMed

    Brochhausen, Christoph; Turial, Salmai; Müller, Felix K P; Schmitt, Volker H; Coerdt, Wiltrud; Wihlm, Jean-Marie; Schier, Felix; Kirkpatrick, C James

    2012-06-01

    Pectus excavatum and pectus carinatum represent the most frequent chest wall deformations. However, the pathogenesis is still poorly understood and research results remain inconsistent. To focus on the recent state of knowledge, we summarize and critically discuss the pathological concepts based on the history of these entities, beginning with the first description in the sixteenth century. Based on the early clinical descriptions, we review and discuss the different pathogenetic hypotheses. To open new perspectives for the potential pathomechanisms, the embryonic and foetal development of the ribs and the sternum is highlighted following the understanding that the origin of these deformities is given by the disruption in the maturation of the parasternal region. In the second, different therapeutical techniques are highlighted and based on the pathogenetic hypotheses and the embryological knowledge potential new biomaterial-based perspectives with interesting insights for tissue engineering-based treatment options are presented.

  10. Pectus excavatum: history, hypotheses and treatment options

    PubMed Central

    Brochhausen, Christoph; Turial, Salmai; Müller, Felix K.P.; Schmitt, Volker H.; Coerdt, Wiltrud; Wihlm, Jean-Marie; Schier, Felix; Kirkpatrick, C. James

    2012-01-01

    Pectus excavatum and pectus carinatum represent the most frequent chest wall deformations. However, the pathogenesis is still poorly understood and research results remain inconsistent. To focus on the recent state of knowledge, we summarize and critically discuss the pathological concepts based on the history of these entities, beginning with the first description in the sixteenth century. Based on the early clinical descriptions, we review and discuss the different pathogenetic hypotheses. To open new perspectives for the potential pathomechanisms, the embryonic and foetal development of the ribs and the sternum is highlighted following the understanding that the origin of these deformities is given by the disruption in the maturation of the parasternal region. In the second, different therapeutical techniques are highlighted and based on the pathogenetic hypotheses and the embryological knowledge potential new biomaterial-based perspectives with interesting insights for tissue engineering-based treatment options are presented. PMID:22394989

  11. Current Status and Perspectives Regarding LNA-anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer.

    PubMed

    Nedaeinia, Reza; Avan, Amir; Ahmadian, Mehdi; Nedaee Nia, Sasan; Ranjbar, Maryam; Sharifi, Mohammadreza; Goli, Mohammad; Piroozmand, Ahmad; Nourmohammadi, Esmail; Manian, Mostafa; Ferns, Gordon A; Ghayour-Mobarhan, Majid; Salehi, Rasoul

    2017-04-12

    Colorectal cancer (CRC) is among the leading causes of cancer-related death, principally due to its metastatic spread and multifactorial chemoresistance. The therapeutic failure can also be explained by inter- or intra-tumor genetic heterogeneity and tumor stromal content. Thus, the identification of novel prognostic biomarkers and therapeutic options are warranted in the management of CRC patients. There are data showing that microRNA-21 is elevated in different types of cancer, particularly colon adenocarcinoma and that this is association with a poor prognosis. This suggests that microRNA-21 may be of value as a potential therapeutic target. Furthermore, locked nucleic acid (LNA)-modified oligonucleotides have recently emerged as a therapeutic option for targeting dysregulated miRNAs in cancer therapy, through antisense-based gene silencing. Further work is required to identify innovative anticancer drugs that improve the current therapy either through novel combinatorial approaches or with better efficacy than conventional drugs. We aimed to provide an overview of the preclinical and clinical studies targeting key dysregulated signaling pathways in CRC as well as the therapeutic application of LNA-modified oligonucleotides and miR inhibitors in the treatment of CRC patients. This article is protected by copyright. All rights reserved.

  12. Public health risks of enterobacterial isolates producing extended-spectrum β-lactamases or AmpC β-lactamases in food and food-producing animals: an EU perspective of epidemiology, analytical methods, risk factors, and control options.

    PubMed

    Liebana, Ernesto; Carattoli, Alessandra; Coque, Teresa M; Hasman, Henrik; Magiorakos, Anna-Pelagia; Mevius, Dik; Peixe, Luisa; Poirel, Laurent; Schuepbach-Regula, Gertraud; Torneke, Karolina; Torren-Edo, Jordi; Torres, Carmen; Threlfall, John

    2013-04-01

    The blaESBL and blaAmpC genes in Enterobacteriaceae are spread by plasmid-mediated integrons, insertion sequences, and transposons, some of which are homologous in bacteria from food animals, foods, and humans. These genes have been frequently identified in Escherichia coli and Salmonella from food animals, the most common being blaCTX-M-1, blaCTX-M-14, and blaCMY-2. Identification of risk factors for their occurrence in food animals is complex. In addition to generic antimicrobial use, cephalosporin usage is an important risk factor for selection and spread of these genes. Extensive international trade of animals is a further risk factor. There are no data on the effectiveness of individual control options in reducing public health risks. A highly effective option would be to stop or restrict cephalosporin usage in food animals. Decreasing total antimicrobial use is also of high priority. Implementation of measures to limit strain dissemination (increasing farm biosecurity, controls in animal trade, and other general postharvest controls) are also important.

  13. The cognitive and neural basis of option generation and subsequent choice.

    PubMed

    Kaiser, Stefan; Simon, Joe J; Kalis, Annemarie; Schweizer, Sophie; Tobler, Philippe N; Mojzisch, Andreas

    2013-12-01

    Decision-making research has thoroughly investigated how people choose from a set of externally provided options. However, in ill-structured real-world environments, possible options for action are not defined by the situation but have to be generated by the agent. Here, we apply behavioral analysis (Study 1) and functional magnetic resonance imaging (Study 2) to investigate option generation and subsequent choice. For this purpose, we employ a new experimental task that requires participants to generate options for simple real-world scenarios and to subsequently decide among the generated options. Correlational analysis with a cognitive test battery suggests that retrieval of options from long-term memory is a relevant process during option generation. The results of the fMRI study demonstrate that option generation in simple real-world scenarios recruits the anterior prefrontal cortex. Furthermore, we show that choice behavior and its neural correlates differ between self-generated and externally provided options. Specifically, choice between self-generated options is associated with stronger recruitment of the dorsal anterior cingulate cortex. This impact of option generation on subsequent choice underlines the need for an expanded model of decision making to accommodate choice between self-generated options.

  14. Options for commercial tokamaks

    SciTech Connect

    Dabiri, A.E.; Keeton, D.C.; Thomson, S.L.

    1986-07-01

    Systems studies have been performed at the Fusion Engineering Design Center (FEDC) to assess commercial tokamak options. One study investigates the economics of high-beta operation and determines an optimum operating range of 10 to 20% beta, with a corresponding neutron wall loading of 6 to 8 MW/m/sup 2/. A second study determines conditions under which small, low-power tokamaks can be economically combined into a 1200-MW(electric) multiplex power plant. The results of these studies have directed future efforts at the FEDC toward a high-beta, tokamak design using a modular maintenance configuration.

  15. Adolescent pregnancy options.

    PubMed

    Resnick, M D

    1992-09-01

    The range of pregnancy options available to adolescents each have significant ramifications for future educational and economic achievement. The changing societal context of adolescent pregnancy decision-making are described, and the characteristics of adolescents who choose to terminate their pregnancy, parent their child, or place for adoption are examined. The role of significant others in decision-making and the implications of mandatory parental involvement in pregnancy decision-making is discussed, as well as the roles of schools in promoting the well-being and potential of adolescents considering pregnancy decisions.

  16. Achilles tendinosis: treatment options.

    PubMed

    Lopez, Roberto Gabriel L; Jung, Hong-Geun

    2015-03-01

    Athletes usually complain of an ongoing or chronic pain over the Achilles tendon, but recently even non-athletes are experiencing the same kind of pain which affects their daily activities. Achilles tendinosis refers to a degenerative process of the tendon without histologic or clinical signs of intratendinous inflammation. Treatment is based on whether to stimulate or prevent neovascularization. Thus, until now, there is no consensus as to the best treatment for this condition. This paper aims to review the common ways of treating this condition from the conservative to the surgical options.

  17. Achilles Tendinosis: Treatment Options

    PubMed Central

    Lopez, Roberto Gabriel L.

    2015-01-01

    Athletes usually complain of an ongoing or chronic pain over the Achilles tendon, but recently even non-athletes are experiencing the same kind of pain which affects their daily activities. Achilles tendinosis refers to a degenerative process of the tendon without histologic or clinical signs of intratendinous inflammation. Treatment is based on whether to stimulate or prevent neovascularization. Thus, until now, there is no consensus as to the best treatment for this condition. This paper aims to review the common ways of treating this condition from the conservative to the surgical options. PMID:25729512

  18. Retrieval options study

    SciTech Connect

    Not Available

    1980-03-01

    This Retrieval Options Study is part of the systems analysis activities of the Office of Nuclear Waste Isolation to develop the scientific and technological bases for radioactive waste repositories in various geologic media. The study considers two waste forms, high level waste and spent fuel, and defines various classes of waste retrieval and recovery. A methodology and data base are developed which allow the relative evaluation of retrieval and recovery costs and the following technical criteria: safety; technical feasibility; ease of retrieval; probable intact retrieval time; safeguards; monitoring; criticality; and licensability. A total of 505 repository options are defined and the cost and technical criteria evaluated utilizing a combination of facts and engineering judgments. The repositories evaluated are selected combinations of the following parameters: Geologic Media (salt, granite, basalt, shale); Retrieval Time after Emplacement (5 and 25 years); Emplacement Design (nominal hole, large hole, carbon steel canister, corrosion resistant canister, backfill in hole, nominal sleeves, thick wall sleeves); Emplacement Configuration (single vertical, multiple vertical, single horizontal, multiple horizontal, vaults; Thermal Considerations; (normal design, reduced density, once-through ventilation, recirculated ventilation); Room Backfill; (none, run-of-mine, early, 5 year delay, 25 year delay, decommissioned); and Rate of Retrieval; (same as emplacement, variably slower depending on repository/canister condition).

  19. Treatment Options for Myopia

    PubMed Central

    Gwiazda, Jane

    2009-01-01

    Myopia is a significant public health problem and its prevalence may be increasing over time. The main treatment options of single vision spectacle lenses, contact lenses, and refractive surgery do not slow the accompanying eye growth or retard the physiological changes associated with excessive axial elongation. High myopia is a predisposing factor for retinal detachment, myopic retinopathy, and glaucoma, contributing to loss of vision and blindness. The high prevalence of myopia and its prominence as a public health problem emphasize the importance of finding effective treatments that slow myopia progression and axial elongation. Treatments that have been investigated include various types of spectacle lenses and contact lenses, as well as pharmaceutical agents such as atropine and pirenzepine. The bulk of evidence from well-conducted studies shows that overall, most therapies for myopia have small treatment benefits that last for a relatively short period of time or have significant side effects. Some therapies may be more effective in subsets of myopic children. This review of treatment options for myopia will emphasize recent results from well-designed clinical studies and will suggest possible future therapies. PMID:19390466

  20. Fuel Cells: A Real Option for Unmanned Aerial Vehicles Propulsion

    PubMed Central

    2014-01-01

    The possibility of implementing fuel cell technology in Unmanned Aerial Vehicle (UAV) propulsion systems is considered. Potential advantages of the Proton Exchange Membrane or Polymer Electrolyte Membrane (PEMFC) and Direct Methanol Fuel Cells (DMFC), their fuels (hydrogen and methanol), and their storage systems are revised from technical and environmental standpoints. Some operating commercial applications are described. Main constraints for these kinds of fuel cells are analyzed in order to elucidate the viability of future developments. Since the low power density is the main problem of fuel cells, hybridization with electric batteries, necessary in most cases, is also explored. PMID:24600326

  1. Fuel cells: a real option for Unmanned Aerial Vehicles propulsion.

    PubMed

    González-Espasandín, Óscar; Leo, Teresa J; Navarro-Arévalo, Emilio

    2014-01-01

    The possibility of implementing fuel cell technology in Unmanned Aerial Vehicle (UAV) propulsion systems is considered. Potential advantages of the Proton Exchange Membrane or Polymer Electrolyte Membrane (PEMFC) and Direct Methanol Fuel Cells (DMFC), their fuels (hydrogen and methanol), and their storage systems are revised from technical and environmental standpoints. Some operating commercial applications are described. Main constraints for these kinds of fuel cells are analyzed in order to elucidate the viability of future developments. Since the low power density is the main problem of fuel cells, hybridization with electric batteries, necessary in most cases, is also explored.

  2. Valuation of Real Options as Competitive Prototyping in System Development

    DTIC Science & Technology

    2014-07-01

    Facility (Ceylan & Ford, 2002). The National Ignition Facility ( NIF ) needed to develop slabs of laser glass to be used in the testing of nuclear...glass produced if the production technologies were feasible, were very uncertain as were costs and devel- opment schedules. Although NIF had...relationships with experienced laser glass vendors, none could guarantee successful development within the required time a priori. Therefore, the NIF program

  3. Bringing Reality to "Real Options": An Experiential Exercise

    ERIC Educational Resources Information Center

    Turner, Craig; Turner, Kyle Dean

    2015-01-01

    Issues surrounding the contextual environment in which strategic decisions are made are difficult concepts to grasp, particularly for undergraduate students with little business experience. They are also problematic for graduate students that have not been called on to make such decisions within their career. The authors propose an exercise that…

  4. Bringing Reality to "Real Options": An Experiential Exercise

    ERIC Educational Resources Information Center

    Turner, Craig; Turner, Kyle Dean

    2015-01-01

    Issues surrounding the contextual environment in which strategic decisions are made are difficult concepts to grasp, particularly for undergraduate students with little business experience. They are also problematic for graduate students that have not been called on to make such decisions within their career. The authors propose an exercise that…

  5. Real Options Valuation of e-Learning Projects

    ERIC Educational Resources Information Center

    Freitas, Angilberto; Brandao, Luiz

    2010-01-01

    New information and communication technologies have been gaining widespread use in Distance Education (DE) models. At the same time, the uncertainty in the market demand for this form of higher education is such that the valuation of "e-Learning" projects has become increasingly difficult and complex. This is due to the fact that…

  6. Mediation Plus Options To Resolve the "Real" Problems Underlying Disputes.

    ERIC Educational Resources Information Center

    Beekman, Lyn

    This paper discusses alternatives to court litigation in special education disputes between schools and parents of students with disabilities. It begins by describing problems with the current hearing process and dispelling myths about alternative dispute resolutions (ADR). The advantages and disadvantages of mediation are then outlined, along…

  7. Real Options Valuation of e-Learning Projects

    ERIC Educational Resources Information Center

    Freitas, Angilberto; Brandao, Luiz

    2010-01-01

    New information and communication technologies have been gaining widespread use in Distance Education (DE) models. At the same time, the uncertainty in the market demand for this form of higher education is such that the valuation of "e-Learning" projects has become increasingly difficult and complex. This is due to the fact that…

  8. Mars Surface Habitability Options

    NASA Technical Reports Server (NTRS)

    Howe, A. Scott; Simon, Matthew; Smitherman, David; Howard, Robert; Toups, Larry; Hoffman, Stephen J.

    2015-01-01

    This paper reports on current habitability concepts for an Evolvable Mars Campaign (EMC) prepared by the NASA Human Spaceflight Architecture Team (HAT). For many years NASA has investigated alternative human Mars missions, examining different mission objectives, trajectories, vehicles, and technologies; the combinations of which have been referred to as reference missions or architectures. At the highest levels, decisions regarding the timing and objectives for a human mission to Mars continue to evolve while at the lowest levels, applicable technologies continue to advance. This results in an on-going need for assessments of alternative system designs such as the habitat, a significant element in any human Mars mission scenario, to provide meaningful design sensitivity characterizations to assist decision-makers regarding timing, objectives, and technologies. As a subset of the Evolvable Mars Campaign activities, the habitability team builds upon results from past studies and recommends options for Mars surface habitability compatible with updated technologies.

  9. TOPEX satellite option study

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The basic design of the fleet satellite communication spacecraft (FLTSATCOM) can easily accommodate any of the three payload options for the ocean dynamic topography experiment (TOPEX). The principal mission requirements as well as the payload accommodations and communications systems needed for launching this payload are reviewed. The existing FLTSATCOM satellite design is identified and the approaches for the proposed propulsion system are described in addition to subsystems for mechanical; power; attitude and velocity control; and telemetry, tracking and control are described. The compatability of FLTSATCOM with the launch vehicle is examined and its capabilities vs TOPEX requirements are summarized. Undetermined changes needed to meet data storage, thermal control, and area to mass ratio requirements are discussed. Cost estimates are included for budgetary and planning purposes. The availability of the described design is assessed based on the continuing production of FLTSATCOM spacecraft during the schedule span planned for TOPEX.

  10. Source options for RHIC

    SciTech Connect

    Prelec, K.

    1988-01-01

    Conceptual designs of the RHIC facility are matched to the parameters of existing tandem Van de Graaff accelerators at Brookhaven National Laboratory. It has been shown that tandems could produce many ion species up to gold with sufficient intensities for injection into the BNL booster and further acceleration and storage in AGS and RHIC synchrotrons. There have been, however, questions about the long-term performance of tandem accelerators, in view of their reliability, cost of maintenance, and expected requests for higher intensities than they could provide. A study was done in 1986 to investigate the possibility of replacing the tandems with a more compact preinjector situated close to the booster. This report will review the options for such a preinjector. 5 refs., 4 tabs.

  11. Employee commute options guidance

    SciTech Connect

    Not Available

    1992-12-01

    The Clean Air Act Amendments of 1990 (CAAA) require severe and extreme ozone nonattainment areas and serious carbon monoxide nonattainment areas to establish programs aimed at reducing commute trips to the worksites of large employers. The concerns that lead to the inclusion of the Employee Commute Options (ECO) provision in the Act are that more people are driving than ever before and they are driving longer distances. The purpose of the guidance is to inform the affected State and local jurisdictions of the Clean Air Act requirement, to provide guidance on preparing an approvable State Implementation Plan (SIP) revision, and to discuss various approaches which may help areas achieve Clean Air Act targets through implementation strategies that are the least burdensome and costly to both affected employers and employees.

  12. Mars Surface Habitability Options

    NASA Technical Reports Server (NTRS)

    Howe, A. Scott; Simon, Matthew; Smitherman, David; Howard, Robert; Toups, Larry; Hoffman, Stephen J.

    2015-01-01

    This paper reports on current habitability concepts for an Evolvable Mars Campaign (EMC) prepared by the NASA Human Spaceflight Architecture Team (HAT). For many years NASA has investigated alternative human Mars missions, examining different mission objectives, trajectories, vehicles, and technologies; the combinations of which have been referred to as reference missions or architectures. At the highest levels, decisions regarding the timing and objectives for a human mission to Mars continue to evolve while at the lowest levels, applicable technologies continue to advance. This results in an on-going need for assessments of alternative system designs such as the habitat, a significant element in any human Mars mission scenario, to provide meaningful design sensitivity characterizations to assist decision-makers regarding timing, objectives, and technologies. As a subset of the Evolvable Mars Campaign activities, the habitability team builds upon results from past studies and recommends options for Mars surface habitability compatible with updated technologies.

  13. Early amplification options.

    PubMed

    Gabbard, Sandra Abbott; Schryer, Jennifer

    2003-01-01

    Children with permanent hearing loss have been remediated with hearing amplification devices for decades. The influx of young infants identified with hearing loss through successful newborn hearing screening programs has established a need for amplification resources for infants within the first six months of life. For the approximately two of every 1000 infants born who are identified with bilateral hearing loss [Mehl and Thomson, 1998, Pediatrics 101, p. e4], the use of amplification is commonly the first step in treating the sequella of their loss. The use of hearing aids, combined with early intervention, has been shown to significantly improve the speech and language skills of young children with hearing loss [Yoshinaga-Itano, 2000, Seminars in Hearing 21, p. 309]. Speech and language delays have contributed to compromised academic performance of school aged children with hearing loss [Johnson et al., 1997, Educational Audiology Handbook, Singular Publishing, San Diego]. Most hard-of-hearing and deaf children use hearing aids and other assistive listening devices every day throughout their lifetime and the life expectancy of a hearing aid is only five to eight years. The current challenge for pediatric audiologists is selecting and evaluating the available amplification to provide the best options for children and their families. Amplification technology has seen an explosion in growth the past few years and the options continue to expand rapidly. This article examines currently available amplification technology and reviews the selection criteria that may be used for infants and young children. Issues such as style, type, amplification features, signal processing strategies, and verification and validation tools are also discussed.

  14. RTP as an Optional Service: It's Alive, But Is It Well?

    SciTech Connect

    Goldman, Charles; Barbose, Galen; Neenan, Bernie

    2006-03-10

    Economists have advocated for real-time pricing (RTP) of electricity on the basis of the gains in economic efficiency that would result from charging customers the contemporaneous marginal cost of supplying electricity instead of the average cost. In recent years, RTP has also become the subject of interest in a variety of policy contexts, including integrated resource planning initiatives, ongoing efforts to improve efficiency and reliability in competitive electricity markets, and implementation of default service in states with retail choice. Most experience with RTP has been as an optional service, that is, a self-selecting alternative to the standard utility service. By our count, approximately 70 utilities in the U.S. offered an optional RTP program at some point over the past 20 years. However, many programs are now defunct. In 2003, 47 utilities in the U.S. were still offering an optional RTP program, on either a pilot or permanent basis (see Figure 1). In addition, 10 utilities in states with retail choice currently offer RTP as the default service for large customers that are not under contract with a competitive supplier. Another two utilities have received regulatory approval to do so in the next few years. Although the results of a few optional RTP programs have been publicized, the vast majority of programs have operated in relative obscurity. To provide a wider perspective on utility and customer experience with RTP, we surveyed 43 optional RTP programs offered in 2003. We interviewed RTP program managers and other utility staff, and reviewed publicly available sources, including key regulatory documents and program evaluations. Based on this research, we identified trends related to RTP program history and outlook, program design and implementation, customer participation, and participant price response. The results are both surprising and instructive. We conclude that RTP is indeed alive but is not prospering as well it could. Thus, we offer a

  15. Real Language Meets Real Business

    ERIC Educational Resources Information Center

    Muirhead, Muirhead; Schechter, Sarah

    2016-01-01

    The Real Business Language Challenge was a collaborative pilot project between Coca-Cola Enterprises (CCE) and Routes into Languages East for Year 9 and 10 pupils. It was based on CCE's award-winning Real Business Challenge, part of its highly acclaimed education programme. The Real Business Language Challenge transformed the project into a…

  16. Real-time and Label-free Bio-sensing of Molecular Interactions by Surface Plasmon Resonance: A Laboratory Medicine Perspective

    PubMed Central

    Helmerhorst, Erik; Chandler, David J; Nussio, Matt; Mamotte, Cyril D

    2012-01-01

    Radioactive, chromogenic, fluorescent and other labels have long provided the basis of detection systems for biomolecular interactions including immunoassays and receptor binding studies. However there has been unprecedented growth in a number of powerful label free biosensor technologies over the last decade. While largely at the proof-of-concept stage in terms of clinical applications, the development of more accessible platforms may see surface plasmon resonance (SPR) emerge as one of the most powerful optical detection platforms for the real-time monitoring of biomolecular interactions in a label-free environment. In this review, we provide an overview of SPR principles and current and future capabilities in a diagnostic context, including its application for monitoring a wide range of molecular markers of disease. The advantages and pitfalls of using SPR to study biomolecular interactions are discussed, with particular emphasis on its potential to differentiate subspecies of analytes and the inherent ability for quantitation through calibration-free concentration analysis (CFCA). In addition, recent advances in multiplex applications, high throughput arrays, miniaturisation, and enhancements using noble metal nanoparticles that promise unprecedented sensitivity to the level of single molecule detection, are discussed. In summary, while SPR is not a new technique, technological advances may see SPR quickly emerge as a highly powerful technology, enabling rapid and routine analysis of molecular interactions for a diverse range of targets, including those with clinical applicability. As the technology produces data quickly, in real-time and in a label-free environment, it may well have a significant presence in future developments in lab-on-a-chip technologies including point-of-care devices and personalised medicine. PMID:23267248

  17. Peak load management: Potential options

    SciTech Connect

    Englin, J.E.; De Steese, J.G.; Schultz, R.W.; Kellogg, M.A.

    1989-10-01

    This report reviews options that may be alternatives to transmission construction (ATT) applicable both generally and at specific locations in the service area of the Bonneville Power Administration (BPA). Some of these options have potential as specific alternatives to the Shelton-Fairmount 230-kV Reinforcement Project, which is the focus of this study. A listing of 31 peak load management (PLM) options is included. Estimated costs and normalized hourly load shapes, corresponding to the respective base load and controlled load cases, are considered for 15 of the above options. A summary page is presented for each of these options, grouped with respect to its applicability in the residential, commercial, industrial, and agricultural sectors. The report contains comments on PLM measures for which load shape management characteristics are not yet available. These comments address the potential relevance of the options and the possible difficulty that may be encountered in characterizing their value should be of interest in this investigation. The report also identifies options that could improve the efficiency of the three customer utility distribution systems supplied by the Shelton-Fairmount Reinforcement Project. Potential cogeneration options in the Olympic Peninsula are also discussed. These discussions focus on the options that appear to be most promising on the Olympic Peninsula. Finally, a short list of options is recommended for investigation in the next phase of this study. 9 refs., 24 tabs.

  18. 77 FR 77133 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... real-time series information data. OCC provides a variety of options-related data to Subscribers... Series Information data have requested that such data be provided on a real-time basis throughout each... determined that it can readily implement systems and processes to accommodate real-time feeds of...

  19. Composites: A viable option

    NASA Technical Reports Server (NTRS)

    Mccarty, John E.

    1991-01-01

    While it sounded great to be asked to talk about composites, I found it difficult to select subject areas that would be of real interest. My choice is based on saying some things about where the maturity of the composite aircraft structures is today and what that means in terms of future criteria for application. This focus was the basis for my title selection. The other issue that will be addressed was requested by NASA and focuses on composites structures cost. This fits well with the state-of-the-art interpretations I will discuss first, since the cost issue must be viewed from both the current status and future points of view. The difficulty in presenting something in these areas is not in the subjects themselves but in trying to present a real world viewpoint to an audience of composite experts. So, with recognition of the expertise of the audience, I hope you will see something in this presentation about how to view composite aircraft structure.

  20. Option price and market instability

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.; Yu, Miao

    2017-04-01

    An option pricing formula, for which the price of an option depends on both the value of the underlying security as well as the velocity of the security, has been proposed in Baaquie and Yang (2014). The FX (foreign exchange) options price was empirically studied in Baaquie et al., (2014), and it was found that the model in general provides an excellent fit for all strike prices with a fixed model parameters-unlike the Black-Scholes option price Hull and White (1987) that requires the empirically determined implied volatility surface to fit the option data. The option price proposed in Baaquie and Cao Yang (2014) did not fit the data during the crisis of 2007-2008. We make a hypothesis that the failure of the option price to fit data is an indication of the market's large deviation from its near equilibrium behavior due to the market's instability. Furthermore, our indicator of market's instability is shown to be more accurate than the option's observed volatility. The market prices of the FX option for various currencies are studied in the light of our hypothesis.

  1. AFCI Options Study

    SciTech Connect

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2009-09-01

    This report describes the background and framework for both organizing the discussion and providing information on the potential for nuclear energy R&D to develop alternative nuclear fuel cycles that would address the issues with the current implementations of nuclear power, including nuclear waste disposal, proliferation risk, safety, security, economics, and sustainability. The disposition of used fuel is the cause of many of the concerns, and the possible approaches to used fuel management identify a number of basic technology areas that need to be considered. The basic science in each of the technology areas is discussed, emphasizing what science is currently available, where scientific knowledge may be insufficient, and especially to identify specific areas where transformational discoveries may allow achievement of performance goals not currently attainable. These discussions lead to the wide range of technical options that have been the basis for past and current research and development on advanced nuclear fuel cycles in the United States. The results of this work are then briefly reviewed to show the extent to which such approaches are capable of addressing the issues with nuclear power, the potential for moving further, and the inherent limitations.

  2. Maintenance and supply options

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The object of the Maintenance and Supply Option was to develop a high level operational philosophy related to maintenance and supply operations and incorporate these concepts into the Lunar Base Study. Specific products to be generated during this task were three trade studies and a conceptual design of the Logistic Supply Module. The crew size study was performed to evaluate crew sizes from the baseline size of four to a crew size of eight and determine the preferred crew size. The second trade study was to determine the impact of extending surface stay times and recommend a preferred duration of stay time as a function of crew, consumables, and equipment support capabilities. The third trade study was an evaluation of packaging and storage methods to determine the preferred logistics approach to support the lunar base. A modified scenario was developed and served as the basis of the individual trade studies. Assumptions and guidelines were also developed from experience with Apollo programs, Space Shuttle operations, and Space Station studies. With this information, the trade studies were performed and a conceptual design for the Logistic Supply Module was developed.

  3. Pediatric Glaucoma: Pharmacotherapeutic Options.

    PubMed

    Samant, Monica; Medsinge, Anagha; Nischal, Ken K

    2016-06-01

    Childhood glaucoma is a major therapeutic challenge for pediatric ophthalmologists and glaucoma specialists worldwide. Management depends on the etiology and age at presentation. A variety of drugs are available for the control of intraocular pressure in children; however, none of these drugs have been licensed by the regulatory agencies for use in children. Furthermore, evidence gained from randomized controlled trials in the pediatric population is sparse, and little is known regarding the use of newer anti-glaucoma preparations. This evidence-based review aims to discuss the available pharmacotherapeutic options for glaucoma in children. Topical adrenoceptor blockers, topical and systemic carbonic anhydrase inhibitors, prostaglandin (PG) analogs, adrenoceptor agonists, parasympathomimetics, and combined preparations are available for use in children, but usually as an off-label indication. Therefore, it is important to recognize that serious side effects have been reported, even with topical drops, and measures to reduce systemic absorption should be taken. Most drugs have been shown to have comparable ocular hypotensive effects, with the lowest occurrence of systemic side effects with PG analogs. Whereas a newly introduced prostaglandin analog, tafluprost, and some other preservative-free preparations have shown promising results in adult glaucoma patients, no pediatric reports are available as yet. Future studies may describe their role in treating pediatric glaucoma. This review also shares some suggested treatment pathways for primary congenital glaucoma (PCG), juvenile open angle glaucoma (JOAG), developmental glaucoma, aphakic/pseudophakic glaucoma, and uveitic glaucoma.

  4. Synroc processing options

    SciTech Connect

    Rozsa, R.B.; Hoenig, C.L.

    1981-09-01

    Synroc is a titanate-based ceramic material currently being developed for immobilizing high-level nuclear reactor wastes in solid form. Synroc D is a unique variation of Synroc. It can contain the high-level defense wastes, particularly those in storage at the Savannah River Plant. In this report, we review the early development of the initial Synroc process, discuss modification and other options that simplify it overall, and recommend the future direction of research and development in the processing area. A reference Synroc process is described briefly and contrasted with the Savannah River Laboratory glass-based reference case. Preliminary engineering layouts show Synroc to be a more complex processing operation and, thus, more expensive than the glass-based process. However, we believe that simplifications, which will significantly reduce the cost difference, are possible. Further research and development will continue in the areas of slurry processing, fluidized bed calcination, and mineralization. This last will use sintering, hot uniaxial pressing, or hot isostatic pressing.

  5. Treatment Options for Narcolepsy.

    PubMed

    Barateau, Lucie; Lopez, Régis; Dauvilliers, Yves

    2016-05-01

    Narcolepsy type 1 and narcolepsy type 2 are central disorders of hypersomnolence. Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is associated with hypocretin-1 deficiency. On the other hand, in narcolepsy type 2, cerebrospinal fluid hypocretin-1 levels are normal and cataplexy absent. Despite major advances in our understanding of narcolepsy mechanisms, its current management is only symptomatic. Treatment options may vary from a single drug that targets several symptoms, or multiple medications that each treats a specific symptom. In recent years, narcolepsy treatment has changed with the widespread use of modafinil/armodafinil for daytime sleepiness, antidepressants (selective serotonin and dual serotonin and noradrenalin reuptake inhibitors) for cataplexy, and sodium oxybate for both symptoms. Other psychostimulants can also be used, such as methylphenidate, pitolisant and rarely amphetamines, as third-line therapy. Importantly, clinically relevant subjective and objective measures of daytime sleepiness are required to monitor the treatment efficacy and to provide guidance on whether the treatment goals are met. Associated symptoms and comorbid conditions, such as hypnagogic/hypnopompic hallucinations, sleep paralysis, disturbed nighttime sleep, unpleasant dreams, REM- and non REM-related parasomnias, depressive symptoms, overweight/obesity, and obstructive sleep apnea, should also be taken into account and managed, if required. In the near future, the efficacy of new wake-promoting drugs, anticataplectic agents, hypocretin replacement therapy and immunotherapy at the early stages of the disease should also be evaluated.

  6. Selected Energy Conservation Options for Homeowners: Options, Expenses and Payoffs.

    ERIC Educational Resources Information Center

    Lengyel, Dorothy L.; And Others

    This publication is a check list for homeowners and renters to help them reduce energy costs. The list consists of 126 energy conservation options. These options range from "change clothes instead of adjusting thermostat" and "air conditioners turned off when not home" to "use sink stopper" and "weatherstripping…

  7. On the discontinuous Galerkin method for numerical pricing of basket spread options with the average strike

    NASA Astrophysics Data System (ADS)

    Hozman, J.; Tichý, T.

    2017-07-01

    The paper is based on the results from our recent research on path-dependent multi-asset options. Here we focus on options, payoff of which depends on the difference of the spread of two underlying assets at expiry and their average spread during the life of the option. The main idea uses a concept of the dimensional reduction to the PDE model with only two spatial variables describing this option pricing problem. Then the numerical option pricing scheme arising from the discontinuous Galerkin method is developed. Finally, a simple numerical result is presented on real market data.

  8. Option pricing: a flexible tool to disseminate shared savings contracts.

    PubMed

    Friedberg, Mark W; Buendia, Anthony M; Lauderdale, Katherine E; Hussey, Peter S

    2013-08-01

    Due to volatility in healthcare costs, shared savings contracts can create systematic financial losses for payers, especially when contracting with smaller providers. To improve the business case for shared savings, we calculated the prices of financial options that payers can "sell" to providers to offset these losses. Using 2009 to 2010 member-level total cost of care data from a large commercial health plan, we calculated option prices by applying a bootstrap simulation procedure. We repeated these simulations for providers of sizes ranging from 500 to 60,000 patients and for shared savings contracts with and without key design features (minimum savings thresholds,bonus caps, cost outlier truncation, and downside risk) and under assumptions of zero, 1%, and 2% real cost reductions due to the shared savings contracts. Assuming no real cost reduction and a 50% shared savings rate, per patient option prices ranged from $225 (3.1% of overall costs) for 500-patient providers to $23 (0.3%) for 60,000-patient providers. Introducing minimum savings thresholds, bonus caps, cost outlier truncation, and downside risk reduced these option prices. Option prices were highly sensitive to the magnitude of real cost reductions. If shared savings contracts cause 2% reductions in total costs, option prices fall to zero for all but the smallest providers. Calculating the prices of financial options that protect payers and providers from downside risk can inject flexibility into shared savings contracts, extend such contracts to smaller providers, and clarify the tradeoffs between different contract designs, potentially speeding the dissemination of shared savings.

  9. Expanding contraceptive options.

    PubMed

    1989-01-01

    The goals of Family Health International (FHI) have been to introduce a variety of birth control options to people in developing countries, and to provide information to the user on the advantages and disadvantages of each method. FHI has worked with many developing countries in clinical trials of established as well as new contraceptive methods. These trials played an important part in making 2 sterilization procedures, laparoscopy and minilaparotomy popular for women. Further research improved the methods and have made them the most popular in the world, chosen by 130 million users. FHI is doing clinical trials on a new IUD, that is a copper bearing T-shaped device called the TCu380A. they have collected data on over 10,000 women using IUD's and early analysis indicates TCu380A is more effective than others. FHI is also evaluating devices such as Norplant that will prevent pregnancy up to 5 years by implanting the capsules in the arm. More than 8,000 women are being tested to determine the acceptability of implants in different geographical locations. Other research groups are doing work in 10 additional countries: Bangladesh will expand its program to 24,000 women and Nepal to 8,000 women. Trials are also being conducted on progestogen pills, since they do not lesson the volume of milk in breast feeding. FHI has also worked to introduce creative community-based distribution channels. In one case, specially trained health workers delivered contraceptives door-to-door in over 150,000 households. They found that 2 of 3 women accepted the pills and in a follow up survey 90% were still using them. FHI is now focusing on ways to improve moving new contraceptives from clinical testing on everyday use. They will coordinate training programs, educational material, media campaigns, and efforts with other international organizations, government agencies, and family planning groups.

  10. Delta hedged option valuation with underlying non-Gaussian returns

    NASA Astrophysics Data System (ADS)

    Moriconi, L.

    2007-07-01

    The standard Black-Scholes theory of option pricing is extended to cope with underlying return fluctuations described by general probability distributions. A Langevin process and its related Fokker-Planck equation are devised to model the market stochastic dynamics, allowing us to write and formally solve the generalized Black-Scholes equation implied by dynamical hedging. A systematic expansion around a non-perturbative starting point is then implemented, recovering the Matacz's conjectured option pricing expression. We perform an application of our formalism to the real stock market and find clear evidence that while past financial time series can be used to evaluate option prices before the expiry date with reasonable accuracy, the stochastic character of volatility is an essential ingredient that should necessarily be taken into account in analytical option price modeling.

  11. High rates of hepatitis C virus (HCV) cure using direct-acting antivirals in HIV/HCV-coinfected patients: a real-world perspective.

    PubMed

    Hawkins, Claudia; Grant, Jennifer; Ammerman, Lauren Rose; Palella, Frank; Mclaughlin, Milena; Green, Richard; Mcgregor, Donna; Stosor, Valentina

    2016-09-01

    There are few data on the real-world experience of FDA-approved oral hepatitis C virus (HCV) direct-acting antiviral (DAA) drug combinations in HIV/HCV-coinfected patients. We evaluated the safety and efficacy of DAA therapies in a cohort of HIV/HCV patients in a large urban clinic in Chicago. HIV/HCV-coinfected adults (≥18 years) enrolled in the Northwestern University Viral Hepatitis Registry between January 2013 and June 2015 were analysed. Treated patients received one of the following DAA combinations: sofosbuvir/ledipasvir, sofosbuvir/ribavirin, sofosbuvir/simeprevir or paritaprevir/ritonavir/ombitasvir/dasabuvir ± ribavirin. The primary outcome was sustained virological response at 12 weeks after DAA completion (SVR12). Seventy-seven HIV/HCV patients were evaluated for DAA therapy. Most patients were male (62/77, 81%) and infected with HCV genotype 1 (67/77, 87%). Some 32/77 (42%) were cirrhotic and 29/77 (38%) had received prior treatment with an IFN-containing regimen. DAA therapy was more likely to be started in Caucasians than persons of other ethnicities (P = 0.01). The overall SVR12 rate was 92% in 52 patients who completed therapy and had follow-up by the end of the study: sofosbuvir/simeprevir, 32/33 (97%); sofosbuvir/ribavirin, 4/7 (57%); sofosbuvir/ledipasvir, 11/11 (100%); and paritaprevir/ritonavir/ombitasvir/dasabuvir, 1/1 (100%). Four patients relapsed after therapy with sofosbuvir/simeprevir (n = 1) or sofosbuvir/ribavirin (n = 3). Adverse events were uncommon and did not result in DAA treatment interruption or discontinuation. The HCV DAA combinations of sofosbuvir/ledipasvir and sofosbuvir/simeprevir were highly effective and well tolerated in this diverse population of HIV/HCV-coinfected patients, many of whom had advanced liver disease. HIV coinfection should not be considered a barrier to successful HCV treatment with DAAs. © The Author 2016. Published by Oxford University Press on behalf of the British Society for

  12. For the last time: stock options are an expense.

    PubMed

    Bodie, Zvi; Kaplan, Robert S; Merton, Robert C

    2003-03-01

    Should stock options be recorded as an expense on a company's income statement and balance sheet, or should they remain where they are, relegated to footnotes? The extraordinary boom in share prices during the Internet bubble made critics of option expensing look like spoilsports. But since the crash, the debate has returned with a vengeance. And no wonder: The authors believe the case for expensing options is overwhelming. In this article, Nobel Iaureate Robert Merton, one of the inventors of the Black-Scholes option-pricing model; his coauthor on the classic textbook Finance, Zvi Bodie; and Robert Kaplan, creator of the Balanced Scorecard, examine and dismiss the principal claims put forward by those who continue to oppose options expensing. They demonstrate that stock-option grants do indeed have real cash-flow implications that need to be reported. They show that effective ways certainly exist to quantify those implications. They detail the distortions that relegating stock-option accounting to footnotes creates. And they show why reporting option costs should in no way hamper young companies in their efforts to provide incentives. Options are indeed a powerful incentive, the authors agree, and failing to record a transaction that creates such powerful effects is economically indefensible. Worse, it encourages companies to favor options over alternative incentive systems. It is not the proper role of accounting standards, the authors argue, to distort executive and employee compensation by subsidizing one particular form of compensation and no other. Companies should choose compensation methods according to their economic benefits--not the way they are reported.

  13. Cognitive and Affective Aspects of Creative Option Generation in Everyday Life Situations

    PubMed Central

    Schweizer, T. Sophie; Schmalenberger, Katja M.; Eisenlohr-Moul, Tory A.; Mojzisch, Andreas; Kaiser, Stefan; Funke, Joachim

    2016-01-01

    Which factors influence a human being’s ability to develop new perspectives and be creative? This ability is pivotal for any context in which new cognitions are required, such as innovative endeavors in science and art, or psychotherapeutic settings. In this article, we seek to bring together two research programs investigating the generation of creative options: On the one hand, research on option generation in the decision-making literature and, on the other hand, cognitive and clinical creativity research. Previous decision-making research has largely neglected the topic of generating creative options. Experiments typically provided participants with a clear set of options to choose from, but everyday life situations are less structured and allow countless ways to react. Before choosing an option, agents have to self-generate a set of options to choose from. Such option generation processes have only recently moved to the center of attention. The present study examines the creative quality of self-generated options in daily life situations. A student sample (N = 48) generated options for action in 70 briefly described everyday life scenarios. We rated the quality of the options on three dimensions of creativity- originality, feasibility, and divergence -and linked these qualities to option generation fluency (speed and number of generated options), situational features like the familiarity and the affective valence of the situation in which the options were generated, and trait measures of cognitive performance. We found that when situations were familiar to the participant, greater negative affective valence of the situation was associated with more originality and divergence of generated options. We also found that a higher option generation fluency was associated with a greater maximal originality of options. We complete our article with a joint research agenda for researchers in the decision-making field focusing on option generation and, on the other hand

  14. Cognitive and Affective Aspects of Creative Option Generation in Everyday Life Situations.

    PubMed

    Schweizer, T Sophie; Schmalenberger, Katja M; Eisenlohr-Moul, Tory A; Mojzisch, Andreas; Kaiser, Stefan; Funke, Joachim

    2016-01-01

    Which factors influence a human being's ability to develop new perspectives and be creative? This ability is pivotal for any context in which new cognitions are required, such as innovative endeavors in science and art, or psychotherapeutic settings. In this article, we seek to bring together two research programs investigating the generation of creative options: On the one hand, research on option generation in the decision-making literature and, on the other hand, cognitive and clinical creativity research. Previous decision-making research has largely neglected the topic of generating creative options. Experiments typically provided participants with a clear set of options to choose from, but everyday life situations are less structured and allow countless ways to react. Before choosing an option, agents have to self-generate a set of options to choose from. Such option generation processes have only recently moved to the center of attention. The present study examines the creative quality of self-generated options in daily life situations. A student sample (N = 48) generated options for action in 70 briefly described everyday life scenarios. We rated the quality of the options on three dimensions of creativity- originality, feasibility, and divergence -and linked these qualities to option generation fluency (speed and number of generated options), situational features like the familiarity and the affective valence of the situation in which the options were generated, and trait measures of cognitive performance. We found that when situations were familiar to the participant, greater negative affective valence of the situation was associated with more originality and divergence of generated options. We also found that a higher option generation fluency was associated with a greater maximal originality of options. We complete our article with a joint research agenda for researchers in the decision-making field focusing on option generation and, on the other hand

  15. Identity Options in Russian Textbooks

    ERIC Educational Resources Information Center

    Shardakova, Marya; Pavlenko, Aneta

    2004-01-01

    This article introduces a new analytical approach to the study of identity options offered in foreign and second language textbooks. This approach, grounded in poststructuralist theory and critical discourse analysis, is applied to 2 popular beginning Russian textbooks. Two sets of identity options are examined in the study: imagined learners…

  16. Bounds for Asian basket options

    NASA Astrophysics Data System (ADS)

    Deelstra, Griselda; Diallo, Ibrahima; Vanmaele, Michèle

    2008-09-01

    In this paper we propose pricing bounds for European-style discrete arithmetic Asian basket options in a Black and Scholes framework. We start from methods used for basket options and Asian options. First, we use the general approach for deriving upper and lower bounds for stop-loss premia of sums of non-independent random variables as in Kaas et al. [Upper and lower bounds for sums of random variables, Insurance Math. Econom. 27 (2000) 151-168] or Dhaene et al. [The concept of comonotonicity in actuarial science and finance: theory, Insurance Math. Econom. 31(1) (2002) 3-33]. We generalize the methods in Deelstra et al. [Pricing of arithmetic basket options by conditioning, Insurance Math. Econom. 34 (2004) 55-57] and Vanmaele et al. [Bounds for the price of discrete sampled arithmetic Asian options, J. Comput. Appl. Math. 185(1) (2006) 51-90]. Afterwards we show how to derive an analytical closed-form expression for a lower bound in the non-comonotonic case. Finally, we derive upper bounds for Asian basket options by applying techniques as in Thompson [Fast narrow bounds on the value of Asian options, Working Paper, University of Cambridge, 1999] and Lord [Partially exact and bounded approximations for arithmetic Asian options, J. Comput. Finance 10 (2) (2006) 1-52]. Numerical results are included and on the basis of our numerical tests, we explain which method we recommend depending on moneyness and time-to-maturity.

  17. A Smorgasbord of Assessment Options

    ERIC Educational Resources Information Center

    Bacon, Kathy A.

    2010-01-01

    The wealth of assessment options that exists offers teachers and students a "menu" of selections. Just as matching appetite needs with appropriate food selection is fundamental to a successful dining experience, matching assessment options to targeted achievement needs is crucial to an effective assessment experience. The author uses a…

  18. A Smorgasbord of Assessment Options

    ERIC Educational Resources Information Center

    Bacon, Kathy A.

    2010-01-01

    The wealth of assessment options that exists offers teachers and students a "menu" of selections. Just as matching appetite needs with appropriate food selection is fundamental to a successful dining experience, matching assessment options to targeted achievement needs is crucial to an effective assessment experience. The author uses a…

  19. Multifractal analysis of implied volatility in index options

    NASA Astrophysics Data System (ADS)

    Oh, GabJin

    2014-06-01

    In this paper, we analyze the statistical and the non-linear properties of the log-variations in implied volatility for the CAC40, DAX and S& P500 daily index options. The price of an index option is generally represented by its implied volatility surface, including its smile and skew properties. We utilize a Lévy process model as the underlying asset to deepen our understanding of the intrinsic property of the implied volatility in the index options and estimate the implied volatility surface. We find that the options pricing models with the exponential Lévy model can reproduce the smile or sneer features of the implied volatility that are observed in real options markets. We study the variation in the implied volatility for at-the-money index call and put options, and we find that the distribution function follows a power-law distribution with an exponent of 3.5 ≤ γ ≤ 4.5. Especially, the variation in the implied volatility exhibits multifractal spectral characteristics, and the global financial crisis has influenced the complexity of the option markets.

  20. Procurement Options for New Renewable Electricity Supply

    SciTech Connect

    Kreycik, C. E.; Couture, T. D.; Cory, K. S.

    2011-12-01

    State renewable portfolio standard (RPS) policies require utilities and load-serving entities (LSEs) to procure renewable energy generation. Utility procurement options may be a function of state policy and regulatory preferences, and in some cases, may be dictated by legislative authority. Utilities and LSEs commonly use competitive solicitations or bilateral contracting to procure renewable energy supply to meet RPS mandates. However, policymakers and regulators in several states are beginning to explore the use of alternatives, namely feed-in tariffs (FITs) and auctions to procure renewable energy supply. This report evaluates four procurement strategies (competitive solicitations, bilateral contracting, FITs, and auctions) against four main criteria: (1) pricing; (2) complexity and efficiency of the procurement process; (3) impacts on developers access to markets; and (4) ability to complement utility decision-making processes. These criteria were chosen because they take into account the perspective of each group of stakeholders: ratepayers, regulators, utilities, investors, and developers.

  1. Shuttle Liquid Fly Back Booster Configuration Options

    NASA Technical Reports Server (NTRS)

    Healy, T. J., Jr.

    1998-01-01

    This paper surveys the basic configuration options available to a Liquid Fly Back Booster (LFBB), integrated with the Space Shuttle system. The background of the development of the LFBB concept is given. The influence of the main booster engine (BME) installations and the Fly Back Engine (FBE) installation on the aerodynamic configurations are also discussed. Limits on the LFBB configuration design space imposed by the existing Shuttle flight and ground elements are also described. The objective of the paper is to put the constrains and design space for an LFBB in perspective. The object of the work is to define LFBB configurations that significantly improve safety, operability, reliability and performance of the Shuttle system and dramatically lower operations costs.

  2. Shuttle Liquid Fly Back Booster Configuration Options

    NASA Technical Reports Server (NTRS)

    Healy, Thomas J., Jr.

    1998-01-01

    This paper surveys the basic configuration options available to a Liquid Fly Back Booster (LFBB), integrated with the Space Shuttle system. The background of the development of the LFBB concept is given. The influence of the main booster engine (BME) installations and the fly back engine (FBE) installation on the aerodynamic configurations are also discussed. Limits on the LFBB configuration design space imposed by the existing Shuttle flight and ground elements are also described. The objective of the paper is to put the constrains and design space for an LFBB in perspective. The object of the work is to define LFBB configurations that significantly improve safety, operability, reliability and performance of the Shuttle system and dramatically lower operations costs.

  3. Real Forestry for Real Estate

    ERIC Educational Resources Information Center

    Gagnon, Jennifer; Fisher, Jason

    2013-01-01

    Virginia is poised to see an unprecedented change in forest land ownership. To provide new landowners with information on sustainable forest management, we developed a two-part program, Real Forestry for Real Estate. First, we assembled New Landowner Packets, which contain a variety of sustainable forest management resources. Second, two…

  4. Real Forestry for Real Estate

    ERIC Educational Resources Information Center

    Gagnon, Jennifer; Fisher, Jason

    2013-01-01

    Virginia is poised to see an unprecedented change in forest land ownership. To provide new landowners with information on sustainable forest management, we developed a two-part program, Real Forestry for Real Estate. First, we assembled New Landowner Packets, which contain a variety of sustainable forest management resources. Second, two…

  5. Physics in Medical Diagnosis--An Optional Unit for High Schools.

    ERIC Educational Resources Information Center

    Ronen, Micky; Ganiel, Uri

    1984-01-01

    Describes the general features of a new, optional learning unit that was developed and implemented in Israel high schools. The unit, which focuses on physics in medical diagnosis, deals with real practical problems and does not replace traditional physics. (JN)

  6. GET REAL!

    EPA Science Inventory

    Combined sewer overflow (CSO) is a significant source of pollution in receiving waters. However, implementing a real-time control scheme operates automatic regulators more efficiently to maximize a collection system's storage, treatment, and transport capacities, reducing the vol...

  7. Erectile dysfunction management options in Nigeria.

    PubMed

    Afolayan, Anthony Jide; Yakubu, Musa Toyin

    2009-04-01

    In Nigeria, the prevalence of erectile dysfunction (ED) among patients attending primary care clinics, age-standardized to the U.S. population in 2000 is 57.4%. This is considered high enough to warrant the attention of scientist for critical studies and analysis. The high ED prevalence is associated with etiologies such as psychosexual factors, chronic medical conditions, and some lifestyles. ED constitutes a major public health problem, influencing the patient's well-being and quality of life. It also leads to broken homes and marriages, psychological, social, and physical morbidity. To give an account of various ED management options in Nigeria. Review of peer-reviewed literature, questionnaire, and ethnobotanical survey to some indigenous herb sellers and herbalists. Cross cultural perspectives of ED management in Nigeria. The review suggests that traditional (phytotherapy, zootherapy, and occultism) and nontraditional, orthodox practice (drug therapy, psychological, and behavioral counseling) are applicable to ED management in Nigeria. This review should help in creating awareness into various options available for managing ED in the country, but does not recommend self medication of any form, be it the use of orthodox or herbal remedy.

  8. 48 CFR 552.217-71 - Notice Regarding Option(s).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Notice Regarding Option(s... Notice Regarding Option(s). As prescribed in 517.208(b), insert the following provision: Notice Regarding Option(s) (NOV 1992) The General Services Administration (GSA) has included an option to in order...

  9. Multiple Choice Neurodynamical Model of the Uncertain Option Task

    PubMed Central

    Insabato, Andrea; Pannunzi, Mario; Deco, Gustavo

    2017-01-01

    The uncertain option task has been recently adopted to investigate the neural systems underlying the decision confidence. Latterly single neurons activity has been recorded in lateral intraparietal cortex of monkeys performing an uncertain option task, where the subject is allowed to opt for a small but sure reward instead of making a risky perceptual decision. We propose a multiple choice model implemented in a discrete attractors network. This model is able to reproduce both behavioral and neurophysiological experimental data and therefore provides support to the numerous perspectives that interpret the uncertain option task as a sensory-motor association. The model explains the behavioral and neural data recorded in monkeys as the result of the multistable attractor landscape and produces several testable predictions. One of these predictions may help distinguish our model from a recently proposed continuous attractor model. PMID:28076355

  10. Multiple Choice Neurodynamical Model of the Uncertain Option Task.

    PubMed

    Insabato, Andrea; Pannunzi, Mario; Deco, Gustavo

    2017-01-01

    The uncertain option task has been recently adopted to investigate the neural systems underlying the decision confidence. Latterly single neurons activity has been recorded in lateral intraparietal cortex of monkeys performing an uncertain option task, where the subject is allowed to opt for a small but sure reward instead of making a risky perceptual decision. We propose a multiple choice model implemented in a discrete attractors network. This model is able to reproduce both behavioral and neurophysiological experimental data and therefore provides support to the numerous perspectives that interpret the uncertain option task as a sensory-motor association. The model explains the behavioral and neural data recorded in monkeys as the result of the multistable attractor landscape and produces several testable predictions. One of these predictions may help distinguish our model from a recently proposed continuous attractor model.

  11. 7 CFR Exhibit F to Subpart I of... - Site Option Loan to Technical Assistance Grantees

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... (C) Form FmHA or its successor agency under Public Law 103-354 440-34, “Option to Purchase Real... Housing Obligation Fund Analysis”. The Issue loan/Grant checks transaction will be used to request a check... Public Law 103-354 1940-16, “Promissory Note.” A lien on the optioned real estate will not be taken. (1...

  12. Advanced Nuclear Fuel Cycle Options

    SciTech Connect

    Roald Wigeland; Temitope Taiwo; Michael Todosow; William Halsey; Jess Gehin

    2010-06-01

    A systematic evaluation has been conducted of the potential for advanced nuclear fuel cycle strategies and options to address the issues ascribed to the use of nuclear power. Issues included nuclear waste management, proliferation risk, safety, security, economics and affordability, and sustainability. The two basic strategies, once-through and recycle, and the range of possibilities within each strategy, are considered for all aspects of the fuel cycle including options for nuclear material irradiation, separations if needed, and disposal. Options range from incremental changes to today’s implementation to revolutionary concepts that would require the development of advanced nuclear technologies.

  13. Menopause: Weighing Your Treatment Options

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Menopause Weighing Your Treatment Options Winter 2017 Table of ... What led you to study older women and menopause? I started studying women's health many years ago ...

  14. FS65 Disposition Option Report

    SciTech Connect

    Wenz, Tracy R.

    2015-09-25

    This report outlines the options for dispositioning the MOX fuel stored in FS65 containers at LANL. Additional discussion regarding the support equipment for loading and unloading the FS65 transport containers is included at the end of the report.

  15. Recruitment services: a viable option.

    PubMed

    Brackin, P; Good, J

    1988-01-01

    Medical recruiters are quickly becoming a viable option in the search for qualified imaging technologists. The purpose of this paper is to familiarize the manager with the services offered by a recruiting agency.

  16. Manned Mars mission astronomy options

    NASA Technical Reports Server (NTRS)

    Suess, S. T.

    1986-01-01

    Astronomical observations during the transit phase, in orbit about Mars, and from the surface present important scientific objectives. Primary astronomical objectives are being summarized by J. Burns (University of New Mexico). Additional or alternative options will be introduced here, together with their strengths, weaknesses, viability, and value. It is important to note at the outset that not all possible options are necessarily important or viable.

  17. Perpetual American options within CTRWs

    NASA Astrophysics Data System (ADS)

    Montero, Miquel

    2008-06-01

    Continuous-time random walks are a well suited tool for the description of market behaviour at the smallest scale: the tick-to-tick evolution. We will apply this kind of market model to the valuation of perpetual American options: derivatives with no maturity that can be exercised at any time. Our approach leads to option prices that fulfill financial formulas when canonical assumptions on the dynamics governing the process are made, but it is still suitable for more exotic market conditions.

  18. Urinary incontinence. Noninvasive treatment options.

    PubMed

    Maloney, C; Cafiero, M R

    1999-06-01

    One in six women older than 45 experiences incontinence, but 31% of them never discuss their condition with anyone. A proactive approach on the part of all health care providers is needed to break this silence, particularly among clinicians who care for women. Urinary incontinence is classified as stress, urge, mixed, overflow or functional incontinence. Differential diagnosis of incontinence is essential to choosing appropriate treatment options. This article outlines noninvasive treatment options that are specific to diagnosis.

  19. HIPAA--a real world perspective.

    PubMed

    Nulan, C

    2001-01-01

    An effective and realistic approach to HIPAA compliance requires healthcare organizations to achieve a fundamental shift in attitude, awareness, habits and capabilities in the areas of privacy and security. They must create a sense of accountability among staff, and even patients, for the safeguarding of patient information. Only when this culture shift has occurred, along with the required technological advancements, can HIPAA compliance be realistically achieved. There is still ample time to create the organizational shift necessary, along with technological enhancements, to meet HIPAA requirements. Beyond compliance, HIPAA will benefit the healthcare industry by promoting administrative simplification--the original intention of the Act. And it will require the healthcare industry, in an abbreviated timeframe, to upgrade its level of sophistication in managing information. HIPAA certification springs from an organizational compliance method that has been underway in government for the past two decades. The HIPAA playbook is taken lock, stock and barrel from other Federal guidelines. HIPAA's legislative lineage includes the Healthcare Reform Act of 1993, Paperwork Reduction Act of 1980, Computer Security Act of 1987 and the Privacy Act of 1974. HIPAA means that public and private sector healthcare organizations are going to be required by law to adopt the same information-handling practices that have been in effect in the Federal government for years. That boils down to two things: Standardized formatting of data electronically exchanged between providers, payers and business partners (EDI) Federalization of security and privacy practices within private-sector healthcare information management The key to making HIPAA compliance achievable within a practical timeframe, as well as instituting the culture changes that go with enhanced privacy and security standards, is a process that is largely unfamiliar in the private sector, called administrative certification and accreditation. Certification is an organizational change-management methodology that drives accountability for security down to that level in the organization where it will concretely and tangibly get done. It is a comprehensive managerial assessment of the technical and non-technical security features and other safeguards of a system associated with its use and environment. The assessment seeks to establish and document the extent to which a particular system meets a set of specified security requirements. HIPAA accreditation occurs when all functional managers in an organization have completed reports of what they know they need to do in their areas. They submit that information to an executive official within the organization who functions as the accrediting official for the organization. Accreditation is the formal declaration that an information system is approved to operate in a particular security mode using a prescribed set of safeguards and should be strongly based on the solvable vulnerabilities and residual risks identified during certification. Institutionalizing a practical and formal HIPAA certification program is important to support business activities and can provide several benefits including increased communication within an organization.

  20. Real Heroes.

    ERIC Educational Resources Information Center

    Denenberg, Dennis

    2001-01-01

    Presents stories taken from the book, "50 American Heroes Every Kid Should Meet," explaining that children need to learn about the value of real-life human accomplishments (versus those of athletes, television personalities, and rock stars). The heroes include Elizabeth Blackwell, first American woman doctor; George C. Marshall,…

  1. Real Heroes.

    ERIC Educational Resources Information Center

    Denenberg, Dennis

    2001-01-01

    Presents stories taken from the book, "50 American Heroes Every Kid Should Meet," explaining that children need to learn about the value of real-life human accomplishments (versus those of athletes, television personalities, and rock stars). The heroes include Elizabeth Blackwell, first American woman doctor; George C. Marshall,…

  2. Designing flexible engineering systems utilizing embedded architecture options

    NASA Astrophysics Data System (ADS)

    Pierce, Jeff G.

    This dissertation develops and applies an integrated framework for embedding flexibility in an engineered system architecture. Systems are constantly faced with unpredictability in the operational environment, threats from competing systems, obsolescence of technology, and general uncertainty in future system demands. Current systems engineering and risk management practices have focused almost exclusively on mitigating or preventing the negative consequences of uncertainty. This research recognizes that high uncertainty also presents an opportunity to design systems that can flexibly respond to changing requirements and capture additional value throughout the design life. There does not exist however a formalized approach to designing appropriately flexible systems. This research develops a three stage integrated flexibility framework based on the concept of architecture options embedded in the system design. Stage One defines an eight step systems engineering process to identify candidate architecture options. This process encapsulates the operational uncertainty though scenario development, traces new functional requirements to the affected design variables, and clusters the variables most sensitive to change. The resulting clusters can generate insight into the most promising regions in the architecture to embed flexibility in the form of architecture options. Stage Two develops a quantitative option valuation technique, grounded in real options theory, which is able to value embedded architecture options that exhibit variable expiration behavior. Stage Three proposes a portfolio optimization algorithm, for both discrete and continuous options, to select the optimal subset of architecture options, subject to budget and risk constraints. Finally, the feasibility, extensibility and limitations of the framework are assessed by its application to a reconnaissance satellite system development problem. Detailed technical data, performance models, and cost estimates

  3. Dependable Real-Time Systems

    DTIC Science & Technology

    1991-09-30

    and F. Wang, "On thle Competitiveness of On-Line Real-Time Task Sc~eduling," to appear. Proc. Icai - Time Systemns Symposium, Dec 1991. 6. Biyabaiii, S...Stankovic, and K. Ramrnamritham, "System Support for lRal-’Vi111C Al: A Spring Project Perspective," Workshop on Real-Time .A1, ICAI ., August 198!). 29...Informatics, Computer S,,iety ,f India , t,, aptpear. 41 . Shilh, C. and J. A. Stankovic, "Distributed Deadlock Detection in Ada IRuntinv En vi- ronments," TRI

  4. Lunar Cube Transfer Trajectory Options

    NASA Technical Reports Server (NTRS)

    Folta, David; Dichmann, Donald James; Clark, Pamela E.; Haapala, Amanda; Howell, Kathleen

    2015-01-01

    Numerous Earth-Moon trajectory and lunar orbit options are available for Cubesat missions. Given the limited Cubesat injection infrastructure, transfer trajectories are contingent upon the modification of an initial condition of the injected or deployed orbit. Additionally, these transfers can be restricted by the selection or designs of Cubesat subsystems such as propulsion or communication. Nonetheless, many trajectory options can b e considered which have a wide range of transfer duration, fuel requirements, and final destinations. Our investigation of potential trajectories highlights several options including deployment from low Earth orbit (LEO) geostationary transfer orbits (GTO) and higher energy direct lunar transfer and the use of longer duration Earth-Moon dynamical systems. For missions with an intended lunar orbit, much of the design process is spent optimizing a ballistic capture while other science locations such as Sun-Earth libration or heliocentric orbits may simply require a reduced Delta-V imparted at a convenient location along the trajectory.

  5. Lunar Cube Transfer Trajectory Options

    NASA Technical Reports Server (NTRS)

    Folta, David; Dichmann, Donald J.; Clark, Pamela; Haapala, Amanda; Howell, Kathleen

    2015-01-01

    Numerous Earth-Moon trajectory and lunar orbit options are available for Cubesat missions. Given the limited Cubesat injection infrastructure, transfer trajectories are contingent upon the modification of an initial condition of the injected or deployed orbit. Additionally, these transfers can be restricted by the selection or designs of Cubesat subsystems such as propulsion or communication. Nonetheless, many trajectory options can be considered which have a wide range of transfer durations, fuel requirements, and final destinations. Our investigation of potential trajectories highlights several options including deployment from low Earth orbit (LEO), geostationary transfer orbits (GTO), and higher energy direct lunar transfers and the use of longer duration Earth-Moon dynamical systems. For missions with an intended lunar orbit, much of the design process is spent optimizing a ballistic capture while other science locations such as Sun-Earth libration or heliocentric orbits may simply require a reduced Delta-V imparted at a convenient location along the trajectory.

  6. Treatment options in trigeminal neuralgia

    PubMed Central

    Obermann, Mark

    2010-01-01

    The incidence of trigeminal neuralgia (TN) is 4.3 per 100,000 persons per year, with a slightly higher incidence for women (5.9/100,000) compared with men (3.4/100,000). There is a lack of certainty regarding the aetiology and pathophysiology of TN. The treatment of TN can be very challenging despite the numerous options patients and physicians can choose from. This multitude of treatment options poses the question as to which treatment fits which patient best. The preferred medical treatment for TN consists of anticonvulsant drugs, muscle relaxants and neuroleptic agents. Large-scale placebo-controlled clinical trials are scarce. For patients refractory to medical therapy, Gasserian ganglion percutaneous techniques, gamma knife surgery and microvascular decompression are the most promising invasive treatment options. PMID:21179603

  7. New options and perspectives for proteinuria management after kidney transplantation.

    PubMed

    Soler, María José; Riera, Marta; Gutierrez, Alex; Pascual, Julio

    2012-01-01

    Proteinuria has been strongly correlated with reduced function and graft survival in kidney-transplanted patients. Data regarding new strategies in proteinuria treatment and subsequent allograft survival are lacking. Similarities between chronic graft injury and chronic kidney disease (CKD) suggest that the same therapeutic antiproteinuric tools should be effective in kidney-transplanted patients. The classic strategies to decrease proteinuria such as blood pressure control, nicotine cessation, low-salt diet, and maintaining an ideal body weight seem to be not enough to achieve proteinuria control. Improvements in our understanding of the pathogenesis of CKD have led to the identification of several novel targets for proteinuria management. In this review, we discuss novel pharmacological approaches that aim to decrease proteinuria in CKD patients, including the use of direct renin inhibitors, vitamin D analogs, pentoxifylline, and endothelin receptor antagonists. We also discuss the promise of using antifibrotic agents to treat proteinuria. The identification of new biomarkers of CKD and its progression can help in the selection of the most effective treatment for decreasing proteinuria and maintaining kidney function. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Comparison between three option, four option and five option multiple choice question tests for quality parameters: A randomized study

    PubMed Central

    Vegada, Bhavisha; Shukla, Apexa; Khilnani, Ajeetkumar; Charan, Jaykaran; Desai, Chetna

    2016-01-01

    Background: Most of the academic teachers use four or five options per item of multiple choice question (MCQ) test as formative and summative assessment. Optimal number of options in MCQ item is a matter of considerable debate among academic teachers of various educational fields. There is a scarcity of the published literature regarding the optimum number of option in each item of MCQ in the field of medical education. Objectives: To compare three options, four options, and five options MCQs test for the quality parameters – reliability, validity, item analysis, distracter analysis, and time analysis. Materials and Methods: Participants were 3rd semester M.B.B.S. students. Students were divided randomly into three groups. Each group was given one set of MCQ test out of three options, four options, and five option randomly. Following the marking of the multiple choice tests, the participants’ option selections were analyzed and comparisons were conducted of the mean marks, mean time, validity, reliability and facility value, discrimination index, point biserial value, distracter analysis of three different option formats. Results: Students score more (P = 0.000) and took less time (P = 0.009) for the completion of three options as compared to four options and five options groups. Facility value was more (P = 0.004) in three options group as compared to four and five options groups. There was no significant difference between three groups for the validity, reliability, and item discrimination. Nonfunctioning distracters were more in the four and five options group as compared to three option group. Conclusion: Assessment based on three option MCQs is can be preferred over four option and five option MCQs. PMID:27721545

  9. The Transformation of Reserve Component (RC) Modernization: New Options for DoD?

    DTIC Science & Technology

    2002-01-01

    31 A DoD Perspective on an RC Modernization Tool 34 Chapter 3 Policy Options & Analysis 37 Historical Funding Analysis 37 Average Age of Equipment...Shortages 40 Transformation 42 Transformation Analysis 43 Qualitative Analysis 45 New Policy Options 48 Analysis of Results Summary 50 Other Issues 54...Chapter 4 Conclusions and Recommendations 55 Making New Policy a Win-Win For All Stakeholders 55 Conclusions 56 National Military Strategy (NMS

  10. The PhD Option...and Options.

    ERIC Educational Resources Information Center

    Weinstein, Bob

    1985-01-01

    Two engineers with doctoral degrees weigh factors, pro and con, in pursuing their degree and the different career paths they have taken. One person outlines the steps in academia while the other has moved through several industrial positions. Indicates that the degree can open doors but can also limit options. (DH)

  11. Design Evolution Study - Aging Options

    SciTech Connect

    P. McDaniel

    2002-04-05

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

  12. Patient-friendly financial options.

    PubMed

    Levin, R P

    1999-03-01

    Having flexible payment options ensures that patients will have all of the motivation and information they need to accept care in your office. The HCCC simply offers the chance to make more expensive treatment available to those who need or want it. The small cost of using a HCCC program more than pays for itself--in fact, it costs less than one-third of what you would spend if you were to bill these patients instead. Having consistent financial policies and flexible payment options can dramatically increase your office's productivity and profitability, while expressing your commitment to customer service and high-quality dentistry.

  13. Patient-friendly financial options.

    PubMed

    Levin, R P

    2000-01-01

    Having flexible payment options ensures that patients will have all of the motivation and information that they need to accept care in your office. The HCCC simply offers you the chance to make more expensive treatment available to those who need or want it. The small cost of using an HCCC program more than pays for itself--in fact, it costs less than one-third of what you would spend if you were to bill these patients instead. Having consistent financial policies and flexible payment options can dramatically increase your office's productivity and profitability, while expressing your commitment to customer service and high-quality dentistry.

  14. Newer Management Options in Leprosy

    PubMed Central

    Rao, P Narasimha; Jain, Suman

    2013-01-01

    Newer management options are needed for leprosy control even at present, as it is predicted that new cases of leprosy will continue to appear for many more years in future. This article detail newer methods of clinical grading of peripheral nerve involvement (thickening, tenderness and nerve pain which are subjective in nature) and the advances made in the use of Ultrasonography and Colour Doppler as an objective imaging tool for nerves in leprosy. It also briefly discusses the newer drugs and alternative regimens as therapeutic management options which hold promise for leprosy in future. PMID:23372204

  15. Nonlinear Schrödinger approach to European option pricing

    NASA Astrophysics Data System (ADS)

    Wróblewski, Marcin

    2017-05-01

    This paper deals with numerical option pricing methods based on a Schrödinger model rather than the Black-Scholes model. Nonlinear Schrödinger boundary value problems seem to be alternatives to linear models which better reflect the complexity and behavior of real markets. Therefore, based on the nonlinear Schrödinger option pricing model proposed in the literature, in this paper a model augmented by external atomic potentials is proposed and numerically tested. In terms of statistical physics the developed model describes the option in analogy to a pair of two identical quantum particles occupying the same state. The proposed model is used to price European call options on a stock index. the model is calibrated using the Levenberg-Marquardt algorithm based on market data. A Runge-Kutta method is used to solve the discretized boundary value problem numerically. Numerical results are provided and discussed. It seems that our proposal more accurately models phenomena observed in the real market than do linear models.

  16. Tool for Ranking Research Options

    NASA Technical Reports Server (NTRS)

    Ortiz, James N.; Scott, Kelly; Smith, Harold

    2005-01-01

    Tool for Research Enhancement Decision Support (TREDS) is a computer program developed to assist managers in ranking options for research aboard the International Space Station (ISS). It could likely also be adapted to perform similar decision-support functions in industrial and academic settings. TREDS provides a ranking of the options, based on a quantifiable assessment of all the relevant programmatic decision factors of benefit, cost, and risk. The computation of the benefit for each option is based on a figure of merit (FOM) for ISS research capacity that incorporates both quantitative and qualitative inputs. Qualitative inputs are gathered and partly quantified by use of the time-tested analytical hierarchical process and used to set weighting factors in the FOM corresponding to priorities determined by the cognizant decision maker(s). Then by use of algorithms developed specifically for this application, TREDS adjusts the projected benefit for each option on the basis of levels of technical implementation, cost, and schedule risk. Based partly on Excel spreadsheets, TREDS provides screens for entering cost, benefit, and risk information. Drop-down boxes are provided for entry of qualitative information. TREDS produces graphical output in multiple formats that can be tailored by users.

  17. CHRONIC URTICARIA AND TREATMENT OPTIONS

    PubMed Central

    Godse, Kiran Vasant

    2009-01-01

    Chronic urticaria has a wide spectrum of clinical presentations and causes. Still, despite our best efforts no cause may be found in the majority of cases. The treatment options are: Primary prevention in the form of avoidance of aggravating factors; counseling; antihistamines; leukotriene receptor antagonists; prednisolone; sulfasalazine and a host of immunosuppressives like methotrexate, cyclosporine, omalizumab etc. PMID:20101328

  18. Academic Restructuring: Options and Strategies.

    ERIC Educational Resources Information Center

    Freddo, Thomas F.

    1991-01-01

    For the primary eye care practitioner in the 1990s and beyond, the basic biomedical sciences have supplanted physiological optics as the primary academic discipline underlying the practice of optometry. Several curriculum development options are available to incorporate the needed material, but a core curriculum is essential at all institutions.…

  19. Options for Heart Valve Replacement

    MedlinePlus

    ... Search By Zipcode Search by State SELECT YOUR LANGUAGE Español (Spanish) 简体中文 (Traditional Chinese) 繁体中文 (Simplified Chinese) ... Walk through a step-by-step interactive guide explaining your valve issue and treatment options with helpful ...

  20. Options in energy wood farming

    SciTech Connect

    McConnell, W.V.

    1984-01-01

    A brief description is given of a study sponsored by the US Air Force (Huff, W.J.; Bronson, L.; McConnell, W.V.; Steadman, P.E. (1982) Report, National Technical Information Service No. FESA-T-2124. 26pp. Springfield, Virginia, USA). Five management options were examined for woody biomass production at Eglin Air Force Base (with over 400 000 acres of forest) to determine the feasibility of achieving self sufficiency in energy. Options were: (a) high energy subsidy, intensive crop management (broadleaves); (b) as (a) except that sewage effluent would be used for irrigation and fertilization; (c) low energy subsidy, single species (pine), modified conventional management - shortened rotations (40 years) dense stocking, artificial sowing (or natural regeneration), and an early thinning used for energy; (d) low energy subsidy, dual species management - widely spaced, genetically improved longleaf pine grown on a sawlog rotation (50 years) with multiple cropping of underplanted short rotation (10 years) Choctawhatchee sand pine (Pinus clausa var. immuginata); and (e) low energy subsidy, short rotation (10 years) P. clausa. Option (e) was preferred as the most productive of the low energy subsidy options.

  1. Document Delivery: Evaluating the Options.

    ERIC Educational Resources Information Center

    Ward, Suzanne M.

    1997-01-01

    Discusses options available to libraries for document delivery. Topics include users' needs; cost; copyright compliance; traditional interlibrary loan; types of suppliers; selection criteria, including customer service; new developments in interlibrary loan, including outsourcing arrangements; and the need to evaluate suppliers. (LRW)

  2. Academic Restructuring: Options and Strategies.

    ERIC Educational Resources Information Center

    Freddo, Thomas F.

    1991-01-01

    For the primary eye care practitioner in the 1990s and beyond, the basic biomedical sciences have supplanted physiological optics as the primary academic discipline underlying the practice of optometry. Several curriculum development options are available to incorporate the needed material, but a core curriculum is essential at all institutions.…

  3. An Option in Applied Microbiology.

    ERIC Educational Resources Information Center

    Lee, William E., III

    1988-01-01

    Describes a program option for undergraduate chemical engineering students interested in biotechnology. Discusses how this program is deployed at the University of Southern Florida. Lists courses which apply to this program. Discusses the goals of teaching applied microbiology to engineering majors. (CW)

  4. Introductory Geology: Aspects and Options.

    ERIC Educational Resources Information Center

    Bowen, John E.; And Others

    Included are essays presenting diversified views on questions related to problems, procedures and the impact of the Introductory Course Program (ICP) in geology. The papers of this issue deal with such factors as the financial survival in curricular design and introductory course options, the problems of transfer of majors which may place…

  5. On the asymptotic free boundary for the American put option problem

    NASA Astrophysics Data System (ADS)

    Hedenmalm, Hakan

    2006-02-01

    In practical work with American put options, it is important to be able to know when to exercise the option, and when not to do so. In computer simulation based on the standard theory of geometric Brownian motion for simulating stock price movements, this problem is fairly easy to handle for options with a short lifespan, by analyzing binomial trees. It is considerably more challenging to make the decision for American put options with long lifespan. In order to provide a satisfactory analysis, we look at the corresponding free boundary problem, and show that the free boundary--which is the curve that separates the two decisions, to exercise or not to--has an asymptotic expansion, where the coefficient of the main term is expressed as an integral in terms of the free boundary. This raises the perspective that one could use numerical simulation to approximate the integral and thus get an effective way to make correct decisions for long life options.

  6. Pawnee Nation Energy Option Analyses

    SciTech Connect

    Matlock, M.; Kersey, K.; Riding In, C.

    2009-07-31

    In 2003, the Pawnee Nation leadership identified the need for the tribe to comprehensively address its energy issues. During a strategic energy planning workshop a general framework was laid out and the Pawnee Nation Energy Task Force was created to work toward further development of the tribe’s energy vision. The overarching goals of the “first steps” project were to identify the most appropriate focus for its strategic energy initiatives going forward, and to provide information necessary to take the next steps in pursuit of the “best fit” energy options. Based on the request of Pawnee Nation’s Energy Task Force the research team, consisting Tribal personnel and Summit Blue Consulting, focused on a review of renewable energy resource development potential, funding sources and utility organizational along with energy savings options. Elements of the energy demand forecasting and characterization and demand side options review remained in the scope of work, but were only addressed at a high level. Description of Activities Performed Renewable Energy Resource Development Potential The research team reviewed existing data pertaining to the availability of biomass (focusing on woody biomass, agricultural biomass/bio-energy crops, and methane capture), solar, wind and hydropower resources on the Pawnee-owned lands. Using these data, combined with assumptions about costs and revenue streams, the research team performed preliminary feasibility assessments for each resource category. The research team also reviewed available funding resources and made recommendations to Pawnee Nation highlighting those resources with the greatest potential for financially-viable development, both in the near-term and over a longer time horizon. Energy Efficiency Options While this was not a major focus of the project, the research team highlighted common strategies for reducing energy use in buildings. The team also discussed the benefits of adopting a building energy code and

  7. Climate change: the evidence and our options.

    PubMed

    Thompson, Lonnie G

    2010-01-01

    Glaciers serve as early indicators of climate change. Over the last 35 years, our research team has recovered ice-core records of climatic and environmental variations from the polar regions and from low-latitude high-elevation ice fields from 16 countries. The ongoing widespread melting of high-elevation glaciers and ice caps, particularly in low to middle latitudes, provides some of the strongest evidence to date that a large-scale, pervasive, and, in some cases, rapid change in Earth's climate system is underway. This paper highlights observations of 20th and 21st century glacier shrinkage in the Andes, the Himalayas, and on Mount Kilimanjaro. Ice cores retrieved from shrinking glaciers around the world confirm their continuous existence for periods ranging from hundreds of years to multiple millennia, suggesting that climatological conditions that dominate those regions today are different from those under which these ice fields originally accumulated and have been sustained. The current warming is therefore unusual when viewed from the millennial perspective provided by multiple lines of proxy evidence and the 160-year record of direct temperature measurements. Despite all this evidence, plus the well-documented continual increase in atmospheric greenhouse gas concentrations, societies have taken little action to address this global-scale problem. Hence, the rate of global carbon dioxide emissions continues to accelerate. As a result of our inaction, we have three options: mitigation, adaptation, and suffering.

  8. Climate Change: The Evidence and Our Options

    PubMed Central

    Thompson, Lonnie G

    2010-01-01

    Glaciers serve as early indicators of climate change. Over the last 35 years, our research team has recovered ice-core records of climatic and environmental variations from the polar regions and from low-latitude high-elevation ice fields from 16 countries. The ongoing widespread melting of high-elevation glaciers and ice caps, particularly in low to middle latitudes, provides some of the strongest evidence to date that a large-scale, pervasive, and, in some cases, rapid change in Earth's climate system is underway. This paper highlights observations of 20th and 21st century glacier shrinkage in the Andes, the Himalayas, and on Mount Kilimanjaro. Ice cores retrieved from shrinking glaciers around the world confirm their continuous existence for periods ranging from hundreds of years to multiple millennia, suggesting that climatological conditions that dominate those regions today are different from those under which these ice fields originally accumulated and have been sustained. The current warming is therefore unusual when viewed from the millennial perspective provided by multiple lines of proxy evidence and the 160-year record of direct temperature measurements. Despite all this evidence, plus the well-documented continual increase in atmospheric greenhouse gas concentrations, societies have taken little action to address this global-scale problem. Hence, the rate of global carbon dioxide emissions continues to accelerate. As a result of our inaction, we have three options: mitigation, adaptation, and suffering. PMID:22532707

  9. Studying real-world perceptual expertise

    PubMed Central

    Shen, Jianhong; Mack, Michael L.; Palmeri, Thomas J.

    2014-01-01

    Significant insights into visual cognition have come from studying real-world perceptual expertise. Many have previously reviewed empirical findings and theoretical developments from this work. Here we instead provide a brief perspective on approaches, considerations, and challenges to studying real-world perceptual expertise. We discuss factors like choosing to use real-world versus artificial object domains of expertise, selecting a target domain of real-world perceptual expertise, recruiting experts, evaluating their level of expertise, and experimentally testing experts in the lab and online. Throughout our perspective, we highlight expert birding (also called birdwatching) as an example, as it has been used as a target domain for over two decades in the perceptual expertise literature. PMID:25147533

  10. Studying real-world perceptual expertise.

    PubMed

    Shen, Jianhong; Mack, Michael L; Palmeri, Thomas J

    2014-01-01

    Significant insights into visual cognition have come from studying real-world perceptual expertise. Many have previously reviewed empirical findings and theoretical developments from this work. Here we instead provide a brief perspective on approaches, considerations, and challenges to studying real-world perceptual expertise. We discuss factors like choosing to use real-world versus artificial object domains of expertise, selecting a target domain of real-world perceptual expertise, recruiting experts, evaluating their level of expertise, and experimentally testing experts in the lab and online. Throughout our perspective, we highlight expert birding (also called birdwatching) as an example, as it has been used as a target domain for over two decades in the perceptual expertise literature.

  11. Managing Nuclear Waste: Options Considered

    SciTech Connect

    DOE

    2002-05-02

    Starting in the 1950s, U.S. scientists began to research ways to manage highly radioactive materials accumulating at power plants and other sites nationwide. Long-term surface storage of these materials poses significant potential health, safety, and environmental risks. Scientists studied a broad range of options for managing spent nuclear fuel and high-level radioactive waste. The options included leaving it where it is, disposing of it in various ways, and making it safer through advanced technologies. International scientific consensus holds that these materials should eventually be disposed of deep underground in what is called a geologic repository. In a recent special report, the National Academy of Sciences summarized the various studies and emphasized that geologic disposal is ultimately necessary.

  12. Treatment options for hyperemesis gravidarum.

    PubMed

    Abramowitz, Amy; Miller, Emily S; Wisner, Katherine L

    2017-01-09

    Hyperemesis gravidarum (HG) is a severe and prolonged form of nausea and/or vomiting during pregnancy. HG affects 0.3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss. Initial pharmacologic treatment for HG includes a combination of doxylamine and pyridoxine. Additional interventions include ondansetron or dopamine antagonists such as metoclopramide or promethazine. The options are limited for women who are not adequately treated with these medications. We suggest that mirtazapine is a useful drug in this context and its efficacy has been described in case studies. Mirtazapine acts on noradrenergic, serotonergic, histaminergic, and muscarinic receptors to produce antidepressant, anxiolytic, antiemetic, sedative, and appetite-stimulating effects. Mirtazapine is not associated with an independent increased risk of birth defects. Further investigation of mirtazapine as a treatment for HG holds promise to expand treatment options for women suffering from HG.

  13. Disposition options for separated plutonium

    SciTech Connect

    Hippel, F. von; Feiveson, H. )

    1993-01-01

    Russia and the United States expect to dismantle [approximately]50,000 nuclear warheads containing [approximately]150 tonnes of plutonium as a result of the drastic reductions in tactical nuclear weapons announced by Presidents Bush and Gorbachev during the fall of 1991 and the reductions in strategic weapons agreed to in the START I and START II Treaties. In addition, if current plans for reprocessing spent light water reactor (LWR) fuel are carried out (mainly in Britain and France) [approximately]200 tonnes of civilian plutonium will be separated during the 1990s. This paper addresses the public-policy issues in the U.S. and abroad regarding disposition options as well as some technical aspects for options.

  14. Depleted uranium disposal options evaluation

    SciTech Connect

    Hertzler, T.J.; Nishimoto, D.D.; Otis, M.D.

    1994-05-01

    The Department of Energy (DOE), Office of Environmental Restoration and Waste Management, has chartered a study to evaluate alternative management strategies for depleted uranium (DU) currently stored throughout the DOE complex. Historically, DU has been maintained as a strategic resource because of uses for DU metal and potential uses for further enrichment or for uranium oxide as breeder reactor blanket fuel. This study has focused on evaluating the disposal options for DU if it were considered a waste. This report is in no way declaring these DU reserves a ``waste,`` but is intended to provide baseline data for comparison with other management options for use of DU. To PICS considered in this report include: Retrievable disposal; permanent disposal; health hazards; radiation toxicity and chemical toxicity.

  15. Dynamic option pricing with endogenous stochastic arbitrage

    NASA Astrophysics Data System (ADS)

    Contreras, Mauricio; Montalva, Rodrigo; Pellicer, Rely; Villena, Marcelo

    2010-09-01

    Only few efforts have been made in order to relax one of the key assumptions of the Black-Scholes model: the no-arbitrage assumption. This is despite the fact that arbitrage processes usually exist in the real world, even though they tend to be short-lived. The purpose of this paper is to develop an option pricing model with endogenous stochastic arbitrage, capable of modelling in a general fashion any future and underlying asset that deviate itself from its market equilibrium. Thus, this investigation calibrates empirically the arbitrage on the futures on the S&P 500 index using transaction data from September 1997 to June 2009, from here a specific type of arbitrage called “arbitrage bubble”, based on a t-step function, is identified and hence used in our model. The theoretical results obtained for Binary and European call options, for this kind of arbitrage, show that an investment strategy that takes advantage of the identified arbitrage possibility can be defined, whenever it is possible to anticipate in relative terms the amplitude and timespan of the process. Finally, the new trajectory of the stock price is analytically estimated for a specific case of arbitrage and some numerical illustrations are developed. We find that the consequences of a finite and small endogenous arbitrage not only change the trajectory of the asset price during the period when it started, but also after the arbitrage bubble has already gone. In this context, our model will allow us to calibrate the B-S model to that new trajectory even when the arbitrage already started.

  16. Implementation of power barrier option valuation

    NASA Astrophysics Data System (ADS)

    Cahyani, Agatha C. P.; Sumarti, Novriana

    2015-09-01

    Options are financial instruments that can be utilized to reduce risk in stock investment. Barrier options are one of the major types of options actively used in financial markets where its life period depends on the path of the underlying stock prices. The features of the barrier option can be used to modify other types of options. In this research, the barrier option will be implemented into power option, so it is called power barrier option. This option is an extension of the vanilla barrier options where the Call payoff being considered is defined as P C =max (STβ-Kβ,0 ) , and the Put payoff being considered is defined as P P =max (Kβ-STβ,0 ) . Here β > 0 and β ≠ 1, K is the strike price of the option, and ST is the price of the underlying stock at time maturity T. In this paper, we generate the prices of stock using binomial method which is adjusted to the power option. In the conclusion, the price of American power barrier option is more expensive than the price of European power barrier option.

  17. Fertility options in transgender people.

    PubMed

    De Roo, Chloë; Tilleman, Kelly; T'Sjoen, Guy; De Sutter, Petra

    2016-01-01

    Hormonal and surgical treatments for transgender people have a devastating effect on the possibility for these patients to reproduce. Additionally, transgender people tend to start sex reassignment treatment at a young age, when reproductive wishes are not yet clearly defined nor fulfilled. The most recent Standards of Care of the World Professional Association for Transgender Health recommend clearly informing patients regarding their future reproductive options prior to initiation of treatment. This review gives an overview of the current knowledge and state-of-the-art techniques in the field of fertility preservation for transgender people. Where genital reconstructive surgery definitely results in sterility, hormone therapy on the other hand also has an important, but partially reversible impact on fertility. The current fertility preservation options for trans men are embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation. For trans women, sperm cryopreservation, surgical sperm extraction and testicular tissue cryopreservation are possible. Although certain fertility preservation techniques could be applicable in a standardized manner based on clear biological criteria, the technique that eventually will be performed should be the preferred choice of the patient after extended explanation of all possible options.

  18. Lunar Cube Transfer Trajectory Options

    NASA Technical Reports Server (NTRS)

    Folta, David C.; Dichman, Don; Clark, Pamela; Haapala, Amanda; Howell, Kathleen

    2014-01-01

    Contingent upon the modification of an initial condition of the injected or deployed orbit. Additionally, these designs can be restricted by the selection of the Cubesat subsystem design such as propulsion or communication. Nonetheless, many trajectory options can be designed with have a wide range of transfer durations, fuel requirements, and final destinations. Our investigation of potential trajectories highlights several design options including deployment into low Earth orbit (LEO), geostationary transfer orbits (GTO), and higher energy direct lunar transfer orbits. In addition to direct transfer options from these initial orbits, we also investigate the use of longer duration Earth-Moon dynamical systems. For missions with an intended lunar orbit, much of the design process is spent optimizing a ballistic capture while other science locations such as Sun-Earth libration or heliocentric orbits may simply require a reduced Delta-V imparted at a convenient location along the trajectory. In this article we examine several design options that meet the above limited deployment and subsystem drivers. We study ways that both impulsive and low-thrust Solar Electric Propulsion (SEP) engines can be used to place the Cubesat first into a highly eccentric Earth orbit, enter the Moon's Sphere of Influence, and finally achieve a highly eccentric lunar orbit. We show that such low-thrust transfers are feasible with a realistic micro-thruster model, assuming that the Cubesat can generate sufficient power for the SEP. Two examples are shown here: (1) A Cubestat injected by Exploration Mission 1 (EM-1) then employing low thrust; and (2) a CubSat deployed in a GTO, then employing impulsive maneuvers. For the EM-1 injected initial design, we increase the EM-1 targeted lunar flyby distance to reduce the energy of the lunar flyby to match that of a typical lMoon system heteroclinic manifold. Figure 1 presents an option that encompasses the similar dynamics as that of the ARTEMIS

  19. Exploring Options in Early Childhood Care in Singapore: Programs and Roles

    ERIC Educational Resources Information Center

    Zhang, Kaili C.

    2016-01-01

    Early childhood care options and practices differ around the world, as influenced by societal perspectives and needs. As early educators and policymakers around the world work to improve education and care services to better serve young children and their families, we must consider context-specific values and standards of quality to ensure early…

  20. Exploring Options in Early Childhood Care in Singapore: Programs and Roles

    ERIC Educational Resources Information Center

    Zhang, Kaili C.

    2016-01-01

    Early childhood care options and practices differ around the world, as influenced by societal perspectives and needs. As early educators and policymakers around the world work to improve education and care services to better serve young children and their families, we must consider context-specific values and standards of quality to ensure early…

  1. Stock and option portfolio using fuzzy logic approach

    NASA Astrophysics Data System (ADS)

    Sumarti, Novriana; Wahyudi, Nanang

    2014-03-01

    Fuzzy Logic in decision-making process has been widely implemented in various problems in industries. It is the theory of imprecision and uncertainty that was not based on probability theory. Fuzzy Logic adds values of degree between absolute true and absolute false. It starts with and builds on a set of human language rules supplied by the user. The fuzzy systems convert these rules to their mathematical equivalents. This could simplify the job of the system designer and the computer, and results in much more accurate representations of the way systems behave in the real world. In this paper we examine the decision making process of stock and option trading by the usage of MACD (Moving Average Convergence Divergence) technical analysis and Option Pricing with Fuzzy Logic approach. MACD technical analysis is for the prediction of the trends of underlying stock prices, such as bearish (going downward), bullish (going upward), and sideways. By using Fuzzy C-Means technique and Mamdani Fuzzy Inference System, we define the decision output where the value of MACD is high then decision is "Strong Sell", and the value of MACD is Low then the decision is "Strong Buy". We also implement the fuzzification of the Black-Scholes option-pricing formula. The stock and options methods are implemented on a portfolio of one stock and its options. Even though the values of input data, such as interest rates, stock price and its volatility, cannot be obtain accurately, these fuzzy methods can give a belief degree of the calculated the Black-Scholes formula so we can make the decision on option trading. The results show the good capability of the methods in the prediction of stock price trends. The performance of the simulated portfolio for a particular period of time also shows good return.

  2. Retirement Options to Offer College Faculty.

    ERIC Educational Resources Information Center

    Felicetti, Daniel A.

    1982-01-01

    Retirement options available to institutions are outlined, including early retirement incentives, phased retirement, facilitating consulting opportunities, travel and outplacement services, maintaining community involvement, annuities, and pensions. Suggestions are made for increasing cost-effectiveness and fitting the options to local…

  3. Pawnee Nation Energy Option Analyses

    SciTech Connect

    Matlock, M.; Kersey, K.; Riding In, C.

    2009-07-21

    Pawnee Nation of Oklahoma Energy Option Analyses In 2003, the Pawnee Nation leadership identified the need for the tribe to comprehensively address its energy issues. During a strategic energy planning workshop a general framework was laid out and the Pawnee Nation Energy Task Force was created to work toward further development of the tribe’s energy vision. The overarching goals of the “first steps” project were to identify the most appropriate focus for its strategic energy initiatives going forward, and to provide information necessary to take the next steps in pursuit of the “best fit” energy options. Description of Activities Performed The research team reviewed existing data pertaining to the availability of biomass (focusing on woody biomass, agricultural biomass/bio-energy crops, and methane capture), solar, wind and hydropower resources on the Pawnee-owned lands. Using these data, combined with assumptions about costs and revenue streams, the research team performed preliminary feasibility assessments for each resource category. The research team also reviewed available funding resources and made recommendations to Pawnee Nation highlighting those resources with the greatest potential for financially-viable development, both in the near-term and over a longer time horizon. Findings and Recommendations Due to a lack of financial incentives for renewable energy, particularly at the state level, combined mediocre renewable energy resources, renewable energy development opportunities are limited for Pawnee Nation. However, near-term potential exists for development of solar hot water at the gym, and an exterior wood-fired boiler system at the tribe’s main administrative building. Pawnee Nation should also explore options for developing LFGTE resources in collaboration with the City of Pawnee. Significant potential may also exist for development of bio-energy resources within the next decade. Pawnee Nation representatives should closely monitor

  4. Numerical Algorithm for Delta of Asian Option.

    PubMed

    Zhang, Boxiang; Yu, Yang; Wang, Weiguo

    2015-01-01

    We study the numerical solution of the Greeks of Asian options. In particular, we derive a close form solution of Δ of Asian geometric option and use this analytical form as a control to numerically calculate Δ of Asian arithmetic option, which is known to have no explicit close form solution. We implement our proposed numerical method and compare the standard error with other classical variance reduction methods. Our method provides an efficient solution to the hedging strategy with Asian options.

  5. Options contracts in the nuclear fuel industry

    SciTech Connect

    Fuller, D.M.

    1995-04-01

    This article discusses options trading in the nuclear fuels industry. Although there now exists no formal options market in the nuclear industry, flexibilities, or embedded options, are actually quite common in the long-term supply contracts. The value of these flexibilities can be estimated by applying the methods used to evaluate options. The method used is the Black-Scholes Model, and it is applied to a number of examples.

  6. Cyanobacterial Treatment Options: Permanganate and ...

    EPA Pesticide Factsheets

    This presentation will begin with a brief overview of drinking water treatment options for cyanobacteria and their toxins. The treatment discussion will focus on the impacts of permanganate addition to suspensions of toxin-producing Microcystis aeruginosa, followed by powdered activated carbon (PAC) addition. Results will be presented that show changes in toxin concentrations, chlorophyll-a concentrations and cell membrane integrity. The EPA Small Systems Webinar Presentations allow the dissemination of the latest Agency guidance and research to a large geographically dispersed audience while minimizing taxpayer expense

  7. Energy Options for the Future

    NASA Astrophysics Data System (ADS)

    Sheffield, John; Obenschain, Stephen; Conover, David; Bajura, Rita; Greene, David; Brown, Marilyn; Boes, Eldon; McCarthy, Kathyrn; Christian, David; Dean, Stephen; Kulcinski, Gerald; Denholm, P. L.

    2004-06-01

    This paper summarizes the presentations and discussion at the Energy Options for the Future meeting held at the Naval Research Laboratory in March of 2004. The presentations covered the present status and future potential for coal, oil, natural gas, nuclear, wind, solar, geothermal, and biomass energy sources and the effect of measures for energy conservation. The longevity of current major energy sources, means for resolving or mitigating environmental issues, and the role to be played by yet to be deployed sources, like fusion, were major topics of presentation and discussion.

  8. Minneapolis district-heating options

    NASA Astrophysics Data System (ADS)

    Stovall, T. K.; Borkowski, R. J.; Karnitz, M. A.; Strom, S.; Linwick, K.

    1981-10-01

    The feasibility of a large-scale district heating system for the Minneapolis central city area was investigated. The analysis was based on a previous city of St. Paul Hot-water district heating study and other studies done by a Swedish engineering firm. Capital costs such as building and heat source conversion, pipeline construction, and equipment were used in comparing the projected expenses of various district heating scenarios. Options such as coal, refuse-derived fuel burning, and cogeneration at the Riverside Power Station were discussed as energy supplies for a cost-effective district heating system.

  9. Telemetry Options for LDB Payloads

    NASA Technical Reports Server (NTRS)

    Stilwell, Bryan D.; Field, Christopher J.

    2016-01-01

    The Columbia Scientific Balloon Facility provides Telemetry and Command systems necessary for balloon operations and science support. There are various Line-Of-Sight (LOS) and Over-The-Horizon (OTH) systems and interfaces that provide communications to and from a science payload. This presentation will discuss the current data throughput options available and future capabilities that may be incorporated in the LDB Support Instrumentation Package (SIP) such as doubling the TDRSS data rate. We will also explore some new technologies that could potentially expand the data throughput of OTH communications.

  10. Policy options for responding to the growing challenge from obesity (PorGrow) in Poland.

    PubMed

    Szponar, L; Ciok, J; Dolna, A; Oltarzewski, M

    2007-05-01

    To explore the perspectives of stakeholders towards a range of policy options to respond to obesity in Poland, a multi-criteria mapping method was used. During structured interviews, stakeholders were invited to appraise policy options by reference to criteria of their own choosing. They also provided relative weightings to their criteria, generating overall rankings of the policy options in relation to each other. Efficacy, feasibility and societal benefits were the groups of criteria deemed most important. There was most consensus in favour of options related to health education, particularly in schools, compared with options that aimed at modifying the environment to prevent obesity, i.e. options around physical activity, modifying the supply and demand for food products, and information-related options. There was little support for technological solutions or institutional reforms. There was broad consensus that to reverse the rising trend in the incidence of obesity, it will be necessary to implement a portfolio of measures, but options related to behaviour change through education are most highly regarded. It will also be necessary to invest in improved surveillance and monitoring of Polish dietary practices, levels of physical activity and obesity in terms of data on height, weight and body mass indexes.

  11. Sociological Perspectives.

    ERIC Educational Resources Information Center

    Townley, Charles; Middleton, Mike

    This monograph examines sociological perspectives and their applications. It is intended to help the college student coming to sociology for the first time to recognize that there are several perspectives within sociology and to disentangle the mass of terms associated with each. The first distinctive sociological perspective came from the work of…

  12. Sociological Perspectives.

    ERIC Educational Resources Information Center

    Townley, Charles; Middleton, Mike

    This monograph examines sociological perspectives and their applications. It is intended to help the college student coming to sociology for the first time to recognize that there are several perspectives within sociology and to disentangle the mass of terms associated with each. The first distinctive sociological perspective came from the work of…

  13. 38 CFR 8.25 - Options.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Options. 8.25 Section 8.25 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Optional Settlements § 8.25 Options. Insurance will be paid in a lump sum only when selected by...

  14. 38 CFR 8.25 - Options.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Options. 8.25 Section 8.25 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Optional Settlements § 8.25 Options. Insurance will be paid in a lump sum only when selected by...

  15. Option Fixation: A Cognitive Contributor to Overconfidence

    ERIC Educational Resources Information Center

    Sieck, Winston R.; Merkle, Edgar C.; Van Zandt, Trisha

    2007-01-01

    The ASC model of choice and confidence in general knowledge proposes that respondents first Assess the familiarity of presented options, and then use the high-familiarity option as a retrieval cue to Search memory for the purposes of Constructing an explanation about why that high-familiarity option is true. The ASC process implies that…

  16. 24 CFR 221.775 - Option period.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Option period. 221.775 Section 221.775 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... § 221.775 Option period. The mortgagee may exercise its option to assign within one year following the...

  17. 32 CFR 48.201 - Options.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Options. 48.201 Section 48.201 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN RETIRED SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.201 Options. As provided in § 48.203, a member...

  18. 32 CFR 48.201 - Options.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Options. 48.201 Section 48.201 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN RETIRED SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.201 Options. As provided in § 48.203, a member...

  19. 32 CFR 48.201 - Options.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Options. 48.201 Section 48.201 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN RETIRED SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.201 Options. As provided in § 48.203, a member...

  20. 32 CFR 48.201 - Options.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Options. 48.201 Section 48.201 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN RETIRED SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.201 Options. As provided in § 48.203, a member...

  1. Help Options in CALL: A Systematic Review

    ERIC Educational Resources Information Center

    Cardenas-Claros, Monica S.; Gruba, Paul A.

    2009-01-01

    This paper is a systematic review of research investigating help options in the different language skills in computer-assisted language learning (CALL). In this review, emerging themes along with is-sues affecting help option research are identified and discussed. We argue that help options in CALL are application resources that do not only seem…

  2. Community Options for Transitional Employment.

    ERIC Educational Resources Information Center

    Arterburn, Daniel; And Others

    A community based (Conejo Valley, California) vocational program was designed to give handicapped junior and senior high school students a variety of real world experiences in the natural setting. Advantages of the community based approach include immediate transfer of learning, opportunities for generalization, provision of role models by other…

  3. Feedback as Real-Time Constructions

    ERIC Educational Resources Information Center

    Keiding, Tina Bering; Qvortrup, Ane

    2014-01-01

    This article offers a re-description of feedback and the significance of time in feedback constructions based on systems theory. It describes feedback as internal, real-time constructions in a learning system. From this perspective, feedback is neither immediate nor delayed, but occurs in the very moment it takes place. This article argues for a…

  4. Feedback as Real-Time Constructions

    ERIC Educational Resources Information Center

    Keiding, Tina Bering; Qvortrup, Ane

    2014-01-01

    This article offers a re-description of feedback and the significance of time in feedback constructions based on systems theory. It describes feedback as internal, real-time constructions in a learning system. From this perspective, feedback is neither immediate nor delayed, but occurs in the very moment it takes place. This article argues for a…

  5. Research Options for Controlling Zoonotic Disease in India, 2010–2015

    PubMed Central

    Sekar, Nitin; Shah, Naman K.; Abbas, Syed Shahid; Kakkar, Manish

    2011-01-01

    Background Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India. Methods and Findings Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to ‘social, political and economic’ factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to ‘health policy and systems’ scored highest while those related to ‘research for development of new interventions’ scored the lowest. Conclusions We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors

  6. Correlated continuous time random walk and option pricing

    NASA Astrophysics Data System (ADS)

    Lv, Longjin; Xiao, Jianbin; Fan, Liangzhong; Ren, Fuyao

    2016-04-01

    In this paper, we study a correlated continuous time random walk (CCTRW) with averaged waiting time, whose probability density function (PDF) is proved to follow stretched Gaussian distribution. Then, we apply this process into option pricing problem. Supposing the price of the underlying is driven by this CCTRW, we find this model captures the subdiffusive characteristic of financial markets. By using the mean self-financing hedging strategy, we obtain the closed-form pricing formulas for a European option with and without transaction costs, respectively. At last, comparing the obtained model with the classical Black-Scholes model, we find the price obtained in this paper is higher than that obtained from the Black-Scholes model. A empirical analysis is also introduced to confirm the obtained results can fit the real data well.

  7. Pricing and hedging Asian basket spread options

    NASA Astrophysics Data System (ADS)

    Deelstra, Griselda; Petkovic, Alexandre; Vanmaele, Michèle

    2010-04-01

    Asian options, basket options and spread options have been extensively studied in the literature. However, few papers deal with the problem of pricing general Asian basket spread options. This paper aims to fill this gap. In order to obtain prices and Greeks in a short computation time, we develop approximation formulae based on comonotonicity theory and moment matching methods. We compare their relative performances and explain how to choose the best approximation technique as a function of the Asian basket spread characteristics. We also give explicitly the Greeks for our proposed methods. In the last section we extend our results to options denominated in foreign currency.

  8. Cost-Effectiveness Analysis of Option B+ for HIV Prevention and Treatment of Mothers and Children in Malawi

    PubMed Central

    Fasawe, Olufunke; Avila, Carlos; Shaffer, Nathan; Schouten, Erik; Chimbwandira, Frank; Hoos, David; Nakakeeto, Olive; De Lay, Paul

    2013-01-01

    Background The Ministry of Health in Malawi is implementing a pragmatic and innovative approach for the management of all HIV-infected pregnant women, termed Option B+, which consists of providing life-long antiretroviral treatment, regardless of their CD4 count or clinical stage. Our objective was to determine if Option B+ represents a cost-effective option. Methods A decision model simulates the disease progression of a cohort of HIV-infected pregnant women receiving prophylaxis and antiretroviral therapy, and estimates the number of paediatric infections averted and maternal life years gained over a ten-year time horizon. We assess the cost-effectiveness from the Ministry of Health perspective while taking into account the practical realities of implementing ART services in Malawi. Results If implemented as recommended by the World Health Organization, options A, B and B+ are equivalent in preventing new infant infections, yielding cost effectiveness ratios between US$ 37 and US$ 69 per disability adjusted life year averted in children. However, when the three options are compared to the current practice, the provision of antiretroviral therapy to all mothers (Option B+) not only prevents infant infections, but also improves the ten-year survival in mothers more than four-fold. This translates into saving more than 250,000 maternal life years, as compared to mothers receiving only Option A or B, with savings of 153,000 and 172,000 life years respectively. Option B+ also yields favourable incremental cost effectiveness ratios (ICER) of US$ 455 per life year gained over the current practice. Conclusion In Malawi, Option B+ represents a favorable policy option from a cost-effectiveness perspective to prevent future infant infections, save mothers' lives and reduce orphanhood. Although Option B+ would require more financial resources initially, it would save societal resources in the long-term and represents a strategic option to simplify and integrate HIV services

  9. ATR Spent Fuel Options Study

    SciTech Connect

    Connolly, Michael James; Bean, Thomas E.; Brower, Jeffrey O.; Luke, Dale E.; Patterson, M. W.; Robb, Alan K.; Sindelar, Robert; Smith, Rebecca E.; Tonc, Vincent F.; Tripp, Julia L.; Winston, Philip L.

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  10. Pricing the property claim service (PCS) catastrophe insurance options using gamma distribution

    NASA Astrophysics Data System (ADS)

    Noviyanti, Lienda; Soleh, Achmad Zanbar; Setyanto, Gatot R.

    2017-03-01

    The catastrophic events like earthquakes, hurricanes or flooding are characteristics for some areas, a properly calculated annual premium would be closely as high as the loss insured. From an actuarial perspective, such events constitute the risk that are not insurable. On the other hand people living in such areas need protection. In order to securitize the catastrophe risk, futures or options based on a loss index could be considered. Chicago Board of Trade launched a new class of catastrophe insurance options based on new indices provided by Property Claim Services (PCS). The PCS-option is based on the Property Claim Service Index (PCS-Index). The index are used to determine and payout in writing index-based insurance derivatives. The objective of this paper is to price PCS Catastrophe Insurance Option based on PCS Catastrophe index. Gamma Distribution is used to estimate PCS Catastrophe index distribution.

  11. Promoting self-directed learning using a menu of assessment options: the investment model.

    PubMed

    Rangachari, P K

    2006-12-01

    Undergraduate science students took an Inquiry course in their second (sophomore) year. The course was designed to explore the social life of scientific knowledge. They were given a set of eight assessment options: personal logs, targeted oral examinations, commentaries, mini-lectures, individual explorations, research proposals, book reviews, and problem-solving exercises. Each option had a specific maximum mark (percentage or grade point) associated with it. Students were permitted to select any set of options to obtain their total grade for the course. From the student's perspective, the course provided a valuable learning experience and enabled them to recognize the complexities involved in the process of generating scientific information and making it useful and relevant to the public. The opportunity given to select their own assessment options enhanced their learning. For me, as the sole instructor managing 51 students, the experience was rewarding.

  12. Operational options for green ships

    NASA Astrophysics Data System (ADS)

    Sherbaz, Salma; Duan, Wenyang

    2012-09-01

    Environmental issues and rising fuel prices necessitate better energy-efficiency in all sectors. The shipping industry is one of the major stakeholders, responsible for 3% of global CO2 emissions, 14%-15% of global NO X emissions, and 16% of global SO X emissions. In addition, continuously rising fuel prices are also an incentive to focus on new ways for better energy-effectiveness. The green ship concept requires exploring and implementing technology on ships to increase energy-efficiency and reduce emissions. Ship operation is an important topic with large potential to increase cost-and-energy-effectiveness. This paper provided a comprehensive review of basic concepts, principles, and potential of operational options for green ships. The key challenges pertaining to ship crew i.e. academic qualifications prior to induction, in-service training and motivation were discussed. The author also deliberated on remedies to these challenges.

  13. Options for Martian propellant production

    NASA Technical Reports Server (NTRS)

    Dowler, Warren; French, James; Ramohalli, Kumar

    1991-01-01

    A quantitative evaluation methodology for utilizing in-situ resources on Mars for the production of useful substances. The emphasis is on the chemical processes. Various options considering different feedstock (mostly, carbon dioxide, water, and iron oxides) are carefully examined for the product mix and the energy needs. Oxygen, carbon monoxide, alcohols, and other chemicals are the end products. The chemical processes involve electrolysis, methanation, and variations. It is shown that maximizing the product utility is more important than the production of oxygen, methane, or alcohols. An important factor is the storage of the chemicals produced. The product utility is dependent, to some extent, upon the mission. A combination of the stability, the enthalpy of formation, and the mass fraction of the products is seen to yield a fairly good quantitative feel for the overall utility and maximum mission impact.

  14. Options for Martian propellant production

    NASA Astrophysics Data System (ADS)

    Dowler, Warren; French, James; Ramohalli, Kumar

    A quantitative evaluation methodology for utilizing in-situ resources on Mars for the production of useful substances. The emphasis is on the chemical processes. Various options considering different feedstock (mostly, carbon dioxide, water, and iron oxides) are carefully examined for the product mix and the energy needs. Oxygen, carbon monoxide, alcohols, and other chemicals are the end products. The chemical processes involve electrolysis, methanation, and variations. It is shown that maximizing the product utility is more important than the production of oxygen, methane, or alcohols. An important factor is the storage of the chemicals produced. The product utility is dependent, to some extent, upon the mission. A combination of the stability, the enthalpy of formation, and the mass fraction of the products is seen to yield a fairly good quantitative feel for the overall utility and maximum mission impact.

  15. Therapeutic options for lip augmentation.

    PubMed

    Segall, Lorne; Ellis, David A F

    2007-11-01

    Aesthetic ideals vary with emerging fashion trends and within different cultures. However, over the past few decades, fuller lips have been considered a desirable trait. Many younger patients are presenting for lip augmentation to achieve the sought-after look commonly seen in many fashion magazines. In addition, as individuals age, they lose lip volume, with a thinning of the red lip, some effacement of the vermillion border, and elongation and flattening of the white portion of the lip. Rejuvenation of the lips plays a key role in restoring a more youthful appearance. As a result, lip augmentation appeals to a wide spectrum of patients who present with various different aesthetic goals and expectations. Numerous therapeutic options exist for aesthetic lip augmentation, ranging from temporary and permanent injectable fillers to implants and other surgical techniques.

  16. A Human Resource Management Perspective on Work Alternatives for Older Americans.

    ERIC Educational Resources Information Center

    Paul, Carolyn E.

    This study examined work alternatives for middle-aged and older persons from two perspectives. The first perspective focused on personnel policies of the employer that relate to the development and administration of employment options. The second perspective concentrated on public policy variables that influence or could influence the availability…

  17. Strategic Options Development and Analysis

    NASA Astrophysics Data System (ADS)

    Ackermann, Fran; Eden, Colin

    Strategic Options Development and Analysis (SODA) enables a group or individual to construct a graphical representation of a problematic situation, and thus explore options and their ramifications with respect to a complex system of goals or objectives. In addition the method aims to help groups arrive at a negotiated agreement about how to act to resolve the situation. It is based upon the use of causal mapping - a formally constructed means-ends network - as representation form. Because the picture has been constructed using the natural language of the problem owners it becomes a model of the situation that is ‘owned' by those who define the problem. The use of formalities for the construction of the model makes it amenable to a range of analyses as well as encouraging reflection and a deeper understanding. These analyses can be used in a ‘rough and ready' manner by visual inspection or through the use of specialist causal mapping software (Decision Explorer). Each of the analyses helps a group or individual discover important features of the problem situation, and these features facilitate agreeing agood solution. The SODA process is aimed at helping a group learn about the situation they face before they reach agreements. Most significantly the exploration through the causal map leads to a higher probability of more creative solutions and promotes solutions that are more likely to be implemented because the problem construction process is wider and more likely to include richer social dimensions about the blockages to action and organizational change. The basic theories that inform SODA derive from cognitive psychology and social negotiation, where the model acts as a continuously changing representation of the problematic situation - changing as the views of a person or group shift through learning and exploration. This chapter, jointly written by two leading practitioner academics and the original developers of SODA, Colin Eden and Fran Ackermann

  18. Project REAL (Real Educational Activities of Learning)

    ERIC Educational Resources Information Center

    Lindsay, Dolores

    1977-01-01

    Project REAL (Real Educational Activities of Learning) began as a program for 22 handicapped high school dropouts under age 21 and offered practical instruction in such areas as construction, electronic assembly, and merchandising. (JYC)

  19. Quantitative Framework to Evaluate Alternative Dispute Resolution Investments in Architecture Engineering and Construction Projects Using Option and Real Option Theory

    ERIC Educational Resources Information Center

    Menassa, Carol Chukri

    2009-01-01

    A project-specific dispute resolution ladder (DRL) typically consists of multiple alternative dispute resolution (ADR) techniques that are chosen to assist in mitigating the impact of change orders and claims (CCO) occurring during the project construction phase, and avoid their escalation to protracted disputes that adversely affect a…

  20. Quantitative Framework to Evaluate Alternative Dispute Resolution Investments in Architecture Engineering and Construction Projects Using Option and Real Option Theory

    ERIC Educational Resources Information Center

    Menassa, Carol Chukri

    2009-01-01

    A project-specific dispute resolution ladder (DRL) typically consists of multiple alternative dispute resolution (ADR) techniques that are chosen to assist in mitigating the impact of change orders and claims (CCO) occurring during the project construction phase, and avoid their escalation to protracted disputes that adversely affect a…

  1. Real Estate Education: A Curriculum Guide for a Two-year Post Secondary Program.

    ERIC Educational Resources Information Center

    Overton, R. Jean

    This curriculum guide was designed to assist in the development of associate degree programs and/or options for real estate education in North Carolina community colleges. The real estate education program prescribed by this guide spans six academic quarters. The 28 courses listed cover such subject areas as real estate fundamentals, human…

  2. Real Estate Education: A Curriculum Guide for a Two-year Post Secondary Program.

    ERIC Educational Resources Information Center

    Overton, R. Jean

    This curriculum guide was designed to assist in the development of associate degree programs and/or options for real estate education in North Carolina community colleges. The real estate education program prescribed by this guide spans six academic quarters. The 28 courses listed cover such subject areas as real estate fundamentals, human…

  3. Reducing the Deficit: Spending and Revenue Options

    DTIC Science & Technology

    2011-03-01

    92Option 11 Delay Fielding of the Army’s Ground Combat Vehicle 94Option 12 Terminate the Medium Extended Air Defense System Program 96Option 13 Terminate...higher debt payments might limit the fields of study students would consider and the types of jobs they would seek. Also, borrowers who were in...from one pro- gram to the next, as does the age at which benefits are payable. Pensions paid under the Civil Service Retirement System ( CSRS ) are

  4. Optional forward contracts for electric power markets

    SciTech Connect

    Gedra, T.W.

    1991-01-01

    The use of financial options and forward contracts is discussed in the context of electric power markets. Optional forward contracts are proposed as a mechanism for allocating power consumption and generating among market participants, either in conjunction with, or in place of, the so-called [open quotes]spot[close quotes] market. The role of optional forwards in maintaining system security in a decentralized, deregulated electric power market is also discussed.

  5. Automatic Extraction of JPF Options and Documentation

    NASA Technical Reports Server (NTRS)

    Luks, Wojciech; Tkachuk, Oksana; Buschnell, David

    2011-01-01

    Documenting existing Java PathFinder (JPF) projects or developing new extensions is a challenging task. JPF provides a platform for creating new extensions and relies on key-value properties for their configuration. Keeping track of all possible options and extension mechanisms in JPF can be difficult. This paper presents jpf-autodoc-options, a tool that automatically extracts JPF projects options and other documentation-related information, which can greatly help both JPF users and developers of JPF extensions.

  6. TOPEX satellite concept. TOPEX option study report

    NASA Technical Reports Server (NTRS)

    Meyer, D. P.; Case, C. M.

    1982-01-01

    Candidate bus equipment from the Viking, Applications Explorer Mission, and Small Scientific Satellite programs for application to the TOPEX mission options is assessed. Propulsion module equipment and subsystem candidates from the Applications Explorer Mission satellites and the Small Scientific Satellite spacecraft are evaluated for those TOPEX options. Several subsystem concepts appropriate to the TOPEX options are described. These descriptions consider performance characteristics of the subsystems. Cost and availability information on the candidate equipment and subsystems are also provided.

  7. Novel Treatment Options for Fecal Incontinence

    PubMed Central

    Barker, Adam; Hurley, Jefferson

    2014-01-01

    Fecal incontinence (FI) is a devastating condition affecting a substantial portion of the population. The etiologies of FI are wide ranging, as are the treatment options. When conservative measures fail, often surgical intervention is required. As in any area where a wide range of treatment options exist, there is no one perfect solution. Fortunately, novel treatment options for FI are becoming available, namely, posterior tibial nerve stimulation, magnetic anal sphincter, stem cell transplant, pyloric transplantation, and acupuncture. PMID:25320572

  8. Rationale and design of a global registry to evaluate real-world clinical outcomes in patients with atrial fibrillation and high risk of stroke treated with left atrial appendage occlusion using the AMPLATZER amulet device-Perspective of available/ongoing registries of catheter-based LAA occlusion.

    PubMed

    Hildick-Smith, David; Diener, Hans-Christoph; Schmidt, Boris; Paul, Vincent; Settergren, Magnus; Teiger, Emmanuel; Camm, John; Tondo, Claudio; Landmesser, Ulf

    2017-09-01

    To describe the rationale and design of a global prospective registry on catheter-based left atrial appendage (LAA) occlusion using the second generation AMPLATZER Amulet LAA occlusion device and to provide a comprehensive perspective on available/ongoing registries for catheter-based LAA occlusion. Given the increasing clinical application of catheter-based LAA occlusion, there is an important need for prospective real-world clinical data regarding this cardiac intervention. The Global Amplatzer Amulet LAA registry aims to provide prospective real-world data from an all-comer population of atrial fibrillation (AF) patients undergoing catheter-based LAA occlusion for stroke prevention. This observational, prospective, multicenter registry will provide peri-procedural and long-term clinical outcome data for catheter-based LAA occlusion using a second generation LAA occlusion device. The global registry will enroll 1,000 patients at up to 75 institutions. Patients will be followed for 2 years after implantation. Primary endpoints will report procedural and long-term data on ischemic stroke, systemic embolism, cardiovascular death and major bleeding. The study will involve independent event adjudication and echocardiographic core laboratory evaluation. Long-term follow-up data are expected in 2018. The Global Amplatzer Amulet LAA registry will collect safety and efficacy information on catheter-based LAA occlusion. Characteristics of available and ongoing catheter-based LAA occlusion registries are described. There is an important need for prospective real-world clinical data of catheter-based LAA occlusion given the increasing application of this intervention. The present global real-world registry will expand our knowledge on peri-procedural and long-term outcome of catheter-based LAA occlusion using a second generation occlusion device. © 2017 Wiley Periodicals, Inc.

  9. Solar PV leasing in Singapore: enhancing return on investments with options

    NASA Astrophysics Data System (ADS)

    Song, Shuang; Poh, K. L.

    2017-05-01

    Renewable energy is getting more important nowadays as an alternative to traditional energies. Solar energy, according to Energy Market Authority, is the most viable in the context of Singapore compared to other renewable energy sources due to land constraints. In light of the increasing adoption of solar power in Singapore, this paper focuses on solar PV leasing using a case study. This paper assesses the prospect for solar PV leasing companies in Singapore through the lens of embedded real options. The recent news that solar power is becoming the cheapest form of new electricity presents the leasing company an option to expand the scale of solar PV system. Taking into account this option, the Net Present Value (NPV) of the investment increased significantly compared to the case without real options. Technological developments result in a continuously changing environment with uncertainties. Thus, decision makers need to be aware of the inherent risk associated and identify options to maximize NPV. This upside potential is realized by exercising the managerial flexibility and exploiting the uncertainty. The paper enables solar energy planners to consider possible managerial flexibilities under uncertainties, showing how option thinking can be incorporated in the valuation of solar energy.

  10. Indirect reciprocity with optional interactions.

    PubMed

    Ghang, Whan; Nowak, Martin A

    2015-01-21

    Indirect reciprocity is a mechanism for the evolution of cooperation that is relevant for prosocial behavior among humans. Indirect reciprocity means that my behavior towards you also depends on what you have done to others. Indirect reciprocity is associated with the evolution of social intelligence and human language. Most approaches to indirect reciprocity assume obligatory interactions, but here we explore optional interactions. In any one round a game between two players is offered. A cooperator accepts a game unless the reputation of the other player indicates a defector. For a game to take place, both players must accept. In a game between a cooperator and a defector, the reputation of the defector is revealed to all players with probability Q. After a sufficiently large number of rounds the identity of all defectors is known and cooperators are no longer exploited. The crucial condition for evolution of cooperation can be written as hQB>1, where h is the average number of rounds per person and B=(b/c)-1 specifies the benefit-to-cost ratio. We analyze both stochastic and deterministic evolutionary game dynamics. We study two extensions that deal with uncertainty: hesitation and malicious gossip. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. [Immunological treatment options for schizophrenia].

    PubMed

    Müller, N; Krause, D; Weidinger, E; Schwarz, M

    2014-04-01

    The pathophysiological mechanism leading to dopaminergic dysfunction in schizophrenia is still unclear. Inflammation seems to play a key role. A dysfunction in the activation of the type 1 immune response is associated with decreased activity of the key enzyme of the tryptophan/kynurenine metabolism, indolamine-2.3-dioxygenase (IDO), results in a higher production of kynurenine acid (KYNA)--an N-methyl-D-aspartate antagonist--in the central nervous system (CNS) and decreased glutamatergic neurotransmission. The differential activation of microglial cells and astrocytes, which serve as immune cells in the CNS, contributes to the TH1-TH2 immune imbalance. Antipsychotics, all acting as dopamine D2 receptor antagonists show several shortcomings. The immune effects of antipsychotics rebalance partly the imbalance of the type-1/type-2 immune response and the overproduction of KYNA. The inflammation is associated with higher prostaglandin E2 (PGE2) production and higher cyclo-oxygenase-2 (COX-2) expression. Increasing evidence from clinical studies with COX-2 inhibitors points to an advantageous effect of anti-inflammatory therapy in schizophrenia, especially in the early stages of the disease. Further options of immunomodulatory therapy in schizophrenia are discussed. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Mental disabilities affect method options.

    PubMed

    Best, K

    1999-01-01

    The provision of reproductive health services to people with psychiatric disturbances or mental retardation requires consideration of factors such as the nature of the disability, whether pregnancy would exacerbate the disturbance, the setting in which the person lives, their level of functioning, and their ability to understand the consequences of contraceptive decisions. Schizophrenic women have high rates of unintended pregnancy and are especially vulnerable to exacerbations of their disease in the postpartum period. Women who are depressed, anxious, or suffering from thought disorganization may be unable to use contraceptive methods such as the pill or condoms correctly. This article reviews issues associated with the provision of various contraceptive methods to, first, women with psychiatric conditions and, second, those with intellectual disabilities. It is important that reproductive health services for those with psychiatric disabilities or retardation are not coercive. Providers should be aware of the legal requirements for obtaining informed consent, including an explanation of benefits and risks, options, and a determination of whether the person is competent to understand the information.

  13. Pancreatic cancer from bench to bedside: molecular pathways and treatment options

    PubMed Central

    Kosmidis, Christoforos; Sapalidis, Konstantinos; Kotidis, Efstathios; Mixalopoulos, Nikolaos; Tsavlis, Drosos; Baka, Sofia; Man, Yan-Gao; Kanellos, John

    2016-01-01

    In the last forty years the pancreatic cancer treatment has made advances, however; still novel drugs are needed. It is known that the five year survival rate remains around 5%. The best treatment option still remains surgery, if patients are diagnosed early. In the last decade the biology of pancreatic cancer has been vastly explored and novel agents such as; tyrosine kinase agents, or vaccines have been added as a treatment perspective. The big challenge is now to translate this knowledge in better outcomes for patients. In this current review we will present information from pancreatic cancer diagnosis to molecular pathways and treatment options; current and future. PMID:27275478

  14. Valuation of Capabilities and System Architectural Options to Meet Affordability Requirement

    DTIC Science & Technology

    2014-03-18

    on weight and then make up for the smaller hardware’s lower signal-to- noise ratio (SNR) performance with software that could provide a higher virtual...architectures. Mohr (2009) used real options to value the flexibility of modular cabins able to accommodate changing passenger demands. Silver and de Weck

  15. Gaining Options: A Mathematics Program for Potentially Talented At-Risk Adolescent Girls

    ERIC Educational Resources Information Center

    Reid, Pamela Trotman; Roberts, Sally K.

    2006-01-01

    In response to indicators that a decline in interest in mathematics occurs among girls--particularly those from low-income and minority groups--during middle school, the GO-GIRL (Gaining Options: Girls Investigate Real Life) program was designed to help potentially talented at-risk girls. The program aimed to build mathematical confidence, skills,…

  16. 76 FR 63971 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... Financial Select Sector SPDR Fund (``XLF options''),\\5\\ which is currently traded on the Exchange. The... price and yield performance of the Financial Select Sector of the S&P 500 Index (the ``Index''). The... banks, capital markets, real estate investment trusts, consumer finance, thrifts and mortgage finance...

  17. 5 CFR 870.504 - Optional insurance: Election.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Optional insurance: Election. 870.504...: Election. (a)(1) Each employee must elect or waive Option A, Option B, and Option C coverage, in a manner... election or waiver which remains in effect. The 31-day time limit for Option B or Option C begins on...

  18. 26 CFR 1.422-2 - Incentive stock options defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Incentive stock options defined. 1.422-2 Section... (CONTINUED) INCOME TAXES Certain Stock Options § 1.422-2 Incentive stock options defined. (a) Incentive stock option defined—(1) In general. The term incentive stock option means an option that meets...

  19. 26 CFR 1.422-2 - Incentive stock options defined.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Incentive stock options defined. 1.422-2 Section... (CONTINUED) INCOME TAXES (CONTINUED) Certain Stock Options § 1.422-2 Incentive stock options defined. (a) Incentive stock option defined—(1) In general. The term incentive stock option means an option that...

  20. 26 CFR 1.422-2 - Incentive stock options defined.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Incentive stock options defined. 1.422-2 Section... (CONTINUED) INCOME TAXES (CONTINUED) Certain Stock Options § 1.422-2 Incentive stock options defined. (a) Incentive stock option defined—(1) In general. The term incentive stock option means an option that...

  1. 26 CFR 1.422-2 - Incentive stock options defined.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 5 2011-04-01 2011-04-01 false Incentive stock options defined. 1.422-2 Section... (CONTINUED) INCOME TAXES (CONTINUED) Certain Stock Options § 1.422-2 Incentive stock options defined. (a) Incentive stock option defined—(1) In general. The term incentive stock option means an option that...

  2. 26 CFR 1.422-2 - Incentive stock options defined.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Incentive stock options defined. 1.422-2 Section... (CONTINUED) INCOME TAXES (CONTINUED) Certain Stock Options § 1.422-2 Incentive stock options defined. (a) Incentive stock option defined—(1) In general. The term incentive stock option means an option that...

  3. Options for Kentucky's Energy Future

    SciTech Connect

    Larry Demick

    2012-11-01

    Three important imperatives are being pursued by the Commonwealth of Kentucky: ? Developing a viable economic future for the highly trained and experienced workforce and for the Paducah area that today supports, and is supported by, the operations of the US Department of Energy’s (DOE’s) Paducah Gaseous Diffusion Plant (PGDP). Currently, the PGDP is scheduled to be taken out of service in May, 2013. ? Restructuring the economic future for Kentucky’s most abundant indigenous resource and an important industry – the extraction and utilization of coal. The future of coal is being challenged by evolving and increasing requirements for its extraction and use, primarily from the perspective of environmental restrictions. Further, it is important that the economic value derived from this important resource for the Commonwealth, its people and its economy is commensurate with the risks involved. Over 70% of the extracted coal is exported from the Commonwealth and hence not used to directly expand the Commonwealth’s economy beyond the severance taxes on coal production. ? Ensuring a viable energy future for Kentucky to guarantee a continued reliable and affordable source of energy for its industries and people. Today, over 90% of Kentucky’s electricity is generated by burning coal with a delivered electric power price that is among the lowest in the United States. Anticipated increased environmental requirements necessitate looking at alternative forms of energy production, and in particular electricity generation.

  4. Postdoctoral Opportunities and Career Options

    NASA Astrophysics Data System (ADS)

    Manka, R. H.

    2001-05-01

    Following the completion of a Ph.D. degree, in the sciences a postdoctoral appointment has traditionally been a key step in career development to expand the student's background and broaden their perspective. The postdoctoral appointment often is almost a requirement to obtain some positions in academia and government laboratories. In addition, postdoctoral positions in industry are becoming more common and offer an opportunity to explore a field without making a long-term commitment. We describe the nature of a postdoctoral appointment and discuss the advantages and disadvantages of the recent Ph.D. taking a postdoctoral position. We comment on the role such positions play in university, government and the corporate research. Finally, we describe some of the national postdoctoral opportunities that exist including large programs offered by the National Research Council through Federal laboratories including those of NASA, NOAA, EPA, and the Department of Defense. Exciting new interdisciplinary opportunities such as fellowships at the NASA Astrobiology Institute are summarized, as are international opportunities such as the von Humboldt fellowships in Germany.

  5. Current Treatment Options for Osteoarthritis.

    PubMed

    Lambova, Sevdalina; Hermann, Walter; Müller-Ladner, Ulf

    2017-08-29

    -alpha blockers in OA. The benefit of TNF-alpha blockers in specific sub-groups of patients with higher level of inflammation, objective criteria for the expected responders as well as cost-effectiveness of such treatment is a matter of further research and discussion. New biologic agents that target the nerve growth factor-β are other currently investigated drugs as a potential symptomatic therapeutic option in OA. Significant research has been also focused on revealing potential symptomatic or eventually disease-modifying efficacy of drugs that target bone metabolism due to contemporary notion for the crucial role of the subchondral bone in OA pathology and the positive association between increased subchondral bone turnover and the progressive cartilage loss. A significant delay of joint width narrowing vs placebo has been observed in patients with symptomatic knee OA after treatment with strontium renelate. result and conculsion:The intraarticular administration of platelet-rich plasma is evaluated as potential future therapy and has been tried in knee and hip OA with beneficial effect. Based on the current knowledge about the OA pathogenesis and the undergoing studies, new therapies for OA are awaited both as a safe symptomatic treatment - alternative for the conventional treatment options and as a disease-modifying therapy that would revolutionize the contemporary approach to OA. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. [Surgical options in ulcerative colitis].

    PubMed

    Hultén, L; Ecker, K W

    1998-01-01

    Surgery is needed in every second patient with pancolitis. Historically four surgical options have been developed: conventional ileostomy, ileorectostomy, continent ileostomy (Kock's pouch) and ileo-anal pouch. However, in emergent or unclear situations subtotal colectomy, ileostomy and preservation of the rectum is the most suitable operation. After recovery and in elective indications proctectomy and proctocolectomy establish the general surgical standard. Today, in most cases ileo-pouch-anal anastomosis is performed instead of creation of an ileostomy. Both lowered frequency of defecation and acceptable continence contribute to a better quality of life. However, functional disturbances are not uncommon and result in most cases from complications of the demanding technique. Definitive cure of the colitis is in interference with the risk of pouchitis in about 30%. The cumulative probability to loose the pouch may rise to 15-20% in the long-term course. Thus, ileorectostomy may be considered as a first step of surgical treatment, since pelvic nerve damage is excluded, function is much better and persistent proctitis can be treated topically. The attractively is that ileo-anal pouch can be performed later on, when decreasing function and increasing risk of malignant change will eventually require proctectomy. A Kock-pouch is seldom considered, especially in patients with ileostomy wishing sure fecal control. But the continent reservoir becomes more and more interesting again since it can be reconstructed from a failed ileo-anal pouch without loss of bowel. Conventional ileostomy should be reserved for patients not suitable for reconstructive methods or those who consider pough operations risk. However, it is the safest procedure with absolute cure of disease. The optimal choice of method considers medical and surgical aspects as well as patients conception and desire.

  7. Emerging therapeutic options for asthma.

    PubMed

    Colice, Gene L

    2011-04-01

    Asthma is characterized by eosinophilic airway inflammation and elevated serum immunoglobulin E (IgE) levels. Due to these pathologic features, the foundation of asthma treatment has historically been anti-inflammatory therapy with inhaled corticosteroids (ICSs). Numerous factors in addition to IgE and eosinophils, however, likely play important roles in mediating the airway inflammatory response characteristic of asthma. ICSs are effective therapy for some patients with persistent asthma, but clinical trials have shown that even increasing doses of ICSs under carefully controlled situations does not always result in acceptable asthma control. Consequently, other classes of medications, in addition to ICSs, are recommended in those patients with more severe asthma. The class of medication most commonly used in more severe asthma, along with ICSs, is long-acting inhaled beta2-agonists, but leukotriene modifying agents and anti-IgE monoclonal antibodies may also be used. Agents such as tiotropium, a long-acting inhaled anti-muscarinic agent, and those aimed at inhibiting cytokines, such as mepoluzimab, daclizumab, and etanercept, hold promise in the treatment of asthma. Other agents under investigation include phosphodiesterase type 4 inhibitors and oligonucleotides. Bronchial thermoplasty, a nonpharmacologic option, may also be beneficial in patients with poorly controlled asthma. As our understanding of the complex pathophysiology of asthma increases, it will enable the development of novel therapeutic approaches for patients who are not responding well to traditional treatments. Although more studies are necessary to ensure the efficacy and safety of both pharmacologic and nonpharmacologic approaches, there is future promise for therapeutic advances in severe, persistent asthma.

  8. 16 CFR 432.4 - Optional disclosures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Optional disclosures. 432.4 Section 432.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES POWER OUTPUT CLAIMS FOR AMPLIFIERS UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.4 Optional disclosures. Other operating characteristics...

  9. 16 CFR 432.4 - Optional disclosures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Optional disclosures. 432.4 Section 432.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES POWER OUTPUT CLAIMS FOR AMPLIFIERS UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.4 Optional disclosures. Other operating characteristics...

  10. 16 CFR 432.4 - Optional disclosures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Optional disclosures. 432.4 Section 432.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES POWER OUTPUT CLAIMS FOR AMPLIFIERS UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.4 Optional disclosures. Other operating characteristics...

  11. 16 CFR 432.4 - Optional disclosures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Optional disclosures. 432.4 Section 432.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES POWER OUTPUT CLAIMS FOR AMPLIFIERS UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.4 Optional disclosures. Other operating characteristics...

  12. 16 CFR 432.4 - Optional disclosures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Optional disclosures. 432.4 Section 432.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES POWER OUTPUT CLAIMS FOR AMPLIFIERS UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.4 Optional disclosures. Other operating characteristics...

  13. 26 CFR 1.544-4 - Options.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false Options. 1.544-4 Section 1.544-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be...

  14. 26 CFR 1.544-4 - Options.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Options. 1.544-4 Section 1.544-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be acquired by reason...

  15. 26 CFR 1.544-4 - Options.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false Options. 1.544-4 Section 1.544-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be...

  16. 26 CFR 1.544-4 - Options.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Options. 1.544-4 Section 1.544-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be acquired by reason...

  17. 26 CFR 1.544-4 - Options.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 7 2014-04-01 2013-04-01 true Options. 1.544-4 Section 1.544-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be acquired by reason...

  18. 78 FR 38843 - Single Application Option

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... States Copyright Office 37 CFR Part 202 Single Application Option AGENCY: U.S. Copyright Office, Library... application.'' This application is being introduced in order to provide an additional option for individual... Office's electronic registration system (``eCO''). Such applications are the most administratively simple...

  19. TECHNOLOGICAL OPTIONS FOR ACID RAIN CONTROL

    EPA Science Inventory

    The paper discusses technological options for acid rain control. Compliance with Title IV of the Clean Air Act Amendments of 1990 will require careful scrutiny of a number of issues before selecting control options to reduce sulfur dioxide (SO2) and nitrogen oxide (NOx) emissions...

  20. 24 CFR 221.770 - Assignment option.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Assignment option. 221.770 Section... § 221.770 Assignment option. A mortgagee holding a conditional or firm commitment issued on or before... securing it, directly to the Government National Mortgage Association (GNMA). Upon such assignment...

  1. 24 CFR 221.255 - Assignment option.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Assignment option. 221.255 Section... Assignment option. (a) A mortgagee holding a mortgage insured pursuant to a conditional or firm commitment..., directly to the Government National Mortgage Association (GNMA). Upon such assignment, transfer and...

  2. Bt: One Option for Gypsy Moth Management

    Treesearch

    Deborah C. Mccullough; Leah S. Bauer

    2000-01-01

    Though the gypsy moth will never go away, you have a variety of options to help manage this pest during outbreaks. One option involves the use of Bt to protect tree foliage and reduce the annoyance caused by gypsy moth caterpillars during an outbreak. Bt or Btk refers to a microorganism called Bacillus Thuringeniesis var. kurstaki. Bt has been widely adopted for...

  3. TECHNOLOGICAL OPTIONS FOR ACID RAIN CONTROL

    EPA Science Inventory

    The paper discusses technological options for acid rain control. Compliance with Title IV of the Clean Air Act Amendments of 1990 will require careful scrutiny of a number of issues before selecting control options to reduce sulfur dioxide (SO2) and nitrogen oxide (NOx) emissions...

  4. Writing about Clients: Ethical Considerations and Options

    ERIC Educational Resources Information Center

    Sperry, Len; Pies, Ronald

    2010-01-01

    Today, the decision to prepare clinical case material for publication is a decision that cannot be taken lightly. The decision involves reviewing ethical considerations and choosing among various options to safeguard client privacy. Such options include seeking the client's permission, disguising case material, and developing composite case…

  5. Mission design options for human Mars missions

    NASA Astrophysics Data System (ADS)

    Wooster, Paul D.; Braun, Robert D.; Ahn, Jaemyung; Putnam, Zachary R.

    Trajectory options for conjunction-class human Mars missions are examined, including crewed Earth-Mars trajectories with the option for abort to Earth, with the intent of serving as a resource for mission designers. An analysis of the impact of Earth and Mars entry velocities on aeroassist systems is included, and constraints are suggested for interplanetary trajectories based upon aeroassist system capabilities.

  6. Options in Public Education: A Source Document.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL. Dept. of Program Development/Alternative Schools.

    In this booklet, options (alternatives) for education in the Chicago Public Schools are discussed. Options described are of four types, all focusing on the learning of basic skills: (1) instruction-based, such as Montessori and open schools; (2) curriculum-based, such as magnet schools, academies, environmental schools and multicultural schools;…

  7. 78 FR 35559 - Noncompensatory Partnership Options; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... Internal Revenue Service 26 CFR Part 1 RIN 1545-BA53 Noncompensatory Partnership Options; Correction AGENCY... issued by a partnership. The final regulations generally provide that the exercise of a noncompensatory option does not cause the recognition of immediate income or loss by either the issuing partnership...

  8. 48 CFR 317.107 - Options.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Options. 317.107 Section 317.107 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Multi-year Contracting 317.107 Options. When used as part of...

  9. 48 CFR 53.302 - Optional forms.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Optional forms. 53.302 Section 53.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.302 Optional forms. This section illustrates the...

  10. 48 CFR 53.302 - Optional forms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Optional forms. 53.302 Section 53.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.302 Optional forms. This section illustrates the...

  11. 48 CFR 53.302 - Optional forms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Optional forms. 53.302 Section 53.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.302 Optional forms. This section illustrates the...

  12. 48 CFR 53.302 - Optional forms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Optional forms. 53.302 Section 53.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.302 Optional forms. This section illustrates the...

  13. 48 CFR 53.302 - Optional forms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Optional forms. 53.302 Section 53.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.302 Optional forms. This section illustrates the...

  14. Flexible Work Options within the Organisational System

    ERIC Educational Resources Information Center

    Albion, Majella J.; Chee, Munli

    2006-01-01

    The availability of flexible work options provides an opportunity for individuals to shape their careers in order to optimise their work and life goals. This study takes a systems theory approach to examine how the use of flexible work options influences relationships and interactions in the workplace. The "Flexible Work Options…

  15. 23 CFR 500.104 - State option.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false State option. 500.104 Section 500.104 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.104 State option. Except as specified in § 500.105 (a...

  16. Listeners' Interactions with Help Options in CALL

    ERIC Educational Resources Information Center

    Cárdenas-Claros, Mónica Stella; Gruba, Paul A.

    2014-01-01

    Help options, or in-built application resources designed to provide assistance, have long been an integral component of computer-based second language (L2) listening materials. Despite their potential to promote comprehension and efficiency, research on the role of help options has lagged. Previous research has found that learners do not often…

  17. 42 CFR 457.70 - Program options.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.70 Program options. (a) Health... 42 Public Health 4 2011-10-01 2011-10-01 false Program options. 457.70 Section 457.70...

  18. 42 CFR 457.70 - Program options.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.70 Program options. (a) Health... 42 Public Health 4 2010-10-01 2010-10-01 false Program options. 457.70 Section 457.70...

  19. 42 CFR 457.70 - Program options.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.70 Program options. (a) Health... 42 Public Health 4 2012-10-01 2012-10-01 false Program options. 457.70 Section 457.70...

  20. 42 CFR 457.70 - Program options.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.70 Program options. (a) Health... 42 Public Health 4 2014-10-01 2014-10-01 false Program options. 457.70 Section 457.70...

  1. 42 CFR 457.70 - Program options.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Introduction; State Plans for Child Health Insurance Programs and Outreach Strategies § 457.70 Program options. (a) Health... 42 Public Health 4 2013-10-01 2013-10-01 false Program options. 457.70 Section 457.70...

  2. Flexible Work Options within the Organisational System

    ERIC Educational Resources Information Center

    Albion, Majella J.; Chee, Munli

    2006-01-01

    The availability of flexible work options provides an opportunity for individuals to shape their careers in order to optimise their work and life goals. This study takes a systems theory approach to examine how the use of flexible work options influences relationships and interactions in the workplace. The "Flexible Work Options…

  3. Healthy Option Preferences of Rural Restaurant Customers

    PubMed Central

    Nothwehr, Faryle; Snetselaar, Linda; Dawson, Jeffrey D.; Hradek, Christine; Sepulveda, Marisol

    2009-01-01

    In preparation for an intervention study in three rural Iowa restaurants, 250 customers were surveyed regarding their interest in dietary change, perceptions of the restaurant, and interest in healthy options. Customers were ages 18 to 88, with a mean age of 52, and 53% were women. Most agreed that the restaurant offers healthy meals. Options customers stated they were most likely to order if available included meat that is baked or broiled, whole-wheat bread, fresh fruit or steamed vegetables, and regular salad dressing on the side. They were least interested in low-fat sour cream, low-fat salad dressing, low-fat milk, low-calorie dessert, and holding high-fat ingredients. Women were more likely to indicate interest in healthy options than were men. Interest in several options was also positively associated with age. Increasing the healthy options in restaurants may be especially effective in changing the dietary intake of women and older adults. PMID:19515859

  4. Exploration Architecture Options - ECLSS, EVA, TCS Implications

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Henninger, Don; Lawrence, Carl

    2009-01-01

    Many options for exploration of the Moon and Mars have been identified and evaluated since the Vision for Space Exploration VSE was announced in 2004. Lunar architectures have been identified and addressed in the Lunar Surface Systems team to establish options for how to get to and then inhabit and explore the moon. The Augustine Commission evaluated human space flight for the Obama administration and identified many options for how to conduct human spaceflight in the future. This paper will evaluate the options for exploration of the moon and Mars and those of the Augustine human spaceflight commission for the implications of each architecture on the Environmental Control and Life Support, ExtraVehicular Activity and Thermal Control systems. The advantages and disadvantages of each architecture and options are presented.

  5. Exploration Architecture Options - ECLSS, EVA, TCS Implications

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Henninger, Don; Lawrence, Carl

    2010-01-01

    Many options for exploration of space have been identified and evaluated since the Vision for Space Exploration (VSE) was announced in 2004. Lunar architectures have been identified and addressed in the Lunar Surface Systems team to establish options for how to get to and then inhabit and explore the moon. The Augustine Commission evaluated human space flight for the Obama administration and identified many options for how to conduct human spaceflight in the future. This paper will evaluate the options for exploration of space for the implications of architectures on the Environmental Control and Life Support (ECLSS), ExtraVehicular Activity (EVA) and Thermal Control System (TCS) Systems. The advantages and disadvantages of each architecture and options are presented.

  6. Exploration Architecture Options - ECLSS, EVA, TCS Implications

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Henninger, Don; Lawrence, Carl

    2009-01-01

    Many options for exploration of the Moon and Mars have been identified and evaluated since the Vision for Space Exploration VSE was announced in 2004. Lunar architectures have been identified and addressed in the Lunar Surface Systems team to establish options for how to get to and then inhabit and explore the moon. The Augustine Commission evaluated human space flight for the Obama administration and identified many options for how to conduct human spaceflight in the future. This paper will evaluate the options for exploration of the moon and Mars and those of the Augustine human spaceflight commission for the implications of each architecture on the Environmental Control and Life Support, ExtraVehicular Activity and Thermal Control systems. The advantages and disadvantages of each architecture and options are presented.

  7. Rowing competitions and perspective

    NASA Astrophysics Data System (ADS)

    Flores, Alfinio; Bernhardt, Stephen A.; Shipman, Henry L.

    2015-02-01

    This paper is about integrating the use of graphing technology (specifically, GeoGebra) with principles of motion, principles of perspective, and the concept of vanishing points to model a dynamic event. Students were asked to analyse video images of a rowing competition filmed with a single camera positioned perpendicular to the race. The fixed position of the camera in such races makes it difficult to determine whether a scull closer to the camera is actually overtaking another, more distant scull. The paper illustrates how students in their first year at the university can integrate the use of technology, science, mathematics, and writing to solve a real world problem involving motion.

  8. 5 CFR 870.705 - Amount and election of Option B and Option C.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in force during the applicable period of service required to continue Option B and Option C. (b)(1)(i... either Full Reduction or No Reduction for all of the multiples being continued. (iv) An employee who does... of this part, only the assignee can change from No Reduction to Full Reduction for the Option...

  9. 30 CFR 90.3 - Part 90 option; notice of eligibility; exercise of option.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Part 90 option; notice of eligibility; exercise... DEVELOPMENT OF PNEUMOCONIOSIS General § 90.3 Part 90 option; notice of eligibility; exercise of option. (a... meter of air. Each of these miners shall be notified in writing of eligibility to exercise the...

  10. 30 CFR 90.3 - Part 90 option; notice of eligibility; exercise of option.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Part 90 option; notice of eligibility; exercise... DEVELOPMENT OF PNEUMOCONIOSIS General § 90.3 Part 90 option; notice of eligibility; exercise of option. (a... meter of air. Each of these miners shall be notified in writing of eligibility to exercise the...

  11. 30 CFR 90.3 - Part 90 option; notice of eligibility; exercise of option.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Part 90 option; notice of eligibility; exercise... DEVELOPMENT OF PNEUMOCONIOSIS General § 90.3 Part 90 option; notice of eligibility; exercise of option. (a... meter of air. Each of these miners shall be notified in writing of eligibility to exercise the...

  12. 30 CFR 90.3 - Part 90 option; notice of eligibility; exercise of option.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Part 90 option; notice of eligibility; exercise... DEVELOPMENT OF PNEUMOCONIOSIS General § 90.3 Part 90 option; notice of eligibility; exercise of option. (a... meter of air. Each of these miners shall be notified in writing of eligibility to exercise the...

  13. 30 CFR 90.3 - Part 90 option; notice of eligibility; exercise of option.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Part 90 option; notice of eligibility; exercise... DEVELOPMENT OF PNEUMOCONIOSIS General § 90.3 Part 90 option; notice of eligibility; exercise of option. (a... meter of air. Each of these miners shall be notified in writing of eligibility to exercise the...

  14. Apathy in schizophrenia as a deficit in the generation of options for action.

    PubMed

    Hartmann, Matthias N; Kluge, Agne; Kalis, Annemarie; Mojzisch, Andreas; Tobler, Philippe N; Kaiser, Stefan

    2015-05-01

    Negative symptoms are a core feature of schizophrenia and have been grouped into 2 factors: a motivational factor, which we refer to as apathy, and a diminished expression factor. Recent studies have shown that apathy is closely linked to functional outcome. However, knowledge about its mechanisms and its relation to decision-making is limited. In the current study, we examined whether apathy in schizophrenia is associated with predecisional deficits, that is, deficits in the generation of options for action. We applied verbal protocol analysis to investigate the quantity of options generated in ill-structured real world scenarios in 30 patients with schizophrenia or schizoaffective disorder and 21 healthy control participants. Patients generated significantly fewer options than control participants and clinical apathy ratings correlated negatively with the quantity of generated options. We show that the association between measures of psychopathology and option generation is most pronounced in regard to apathy symptoms and that it is only partially mediated by deficits in verbal fluency. This study provides empirical support for dysfunctional option generation as a possible mechanism for apathy in schizophrenia. Our data emphasize the potential importance of predecisional stages in the development and persistence of apathy symptoms in neuropsychiatric disorders and might also inform the development of novel treatment options in the realm of cognitive remediation.

  15. Comparing Social Security reform options.

    PubMed

    Copeland, Craig

    2005-05-01

    program. This analysis compares "Model 2" from the President's 2001 Commission to Strengthen Social Security (which appears to have the principles for an individual account plan favored by the Bush administration) with three basic options: Current-law benefits with taxes raised to cover the shortfall over the 75-year actuarial period, by removing the existing dollar 90,000 annual wage cap and including all workers. Maintain current benefits until the revenue shortfall occurs, when a "cliff" benefit cut is imposed. A gradual reduction in current-law benefits.

  16. A perspective on fuel diversity

    SciTech Connect

    Ken Costello

    2005-05-01

    Portfolio theory and real options theory can be employed to help determine the appropriate role of different fuel sources and generation technologies in a resource portfolio, both of vertically integrated electric utilities and those that have divested their generation facilities. While compelling arguments can be made for achieving a more fuel-diversified electric sector, how diversification can most effectively be managed poses some hard challenges for policymakers and stakeholders in the regulatory process.

  17. Lack of tolerable treatment options for patients with schizophrenia

    PubMed Central

    Citrome, Leslie; Eramo, Anna; Francois, Clement; Duffy, Ruth; Legacy, Susan N; Offord, Steve J; Krasa, Holly B; Johnston, Stephen S; Guiraud-Diawara, Alice; Kamat, Siddhesh A; Rohman, Patricia

    2015-01-01

    Purpose Atypical antipsychotics (AAs), an effective treatment for schizophrenia, have a range of pharmacologic properties leading to differences in tolerability as well as heterogeneity in treatment response. Individual patient characteristics must be considered when making treatment choices, especially from an adverse event (AE) or tolerability perspective. Despite the availability of numerous AAs, after appraising patient characteristics at the time of treatment selection, physicians may quickly run out of tolerable treatment options. Patients and methods AE risk factors, defined as having either a prior history of an AE or a risk factor for that AE, were determined for Medicaid-insured and Commercially insured patients using database analysis. Patients receiving AA treatment between January 1, 2010 and December 31, 2012 defined the index date of first observed AA prescription during this period. Nine AAs were evaluated for association with AE risk factors as informed by drug prescribing information from the different manufacturers and published meta-analyses. The proportion of patients with pre-index AE risk factors prescribed an AA associated with that risk factor was then determined. Results A high proportion of patients (>80%) were prescribed an AA associated with extrapyramidal symptoms or akathisia despite experiencing extrapyramidal symptoms or akathisia prior to AA treatment initiation. Similar trends were observed among patients with diabetes (>60%) and obesity (>40%). From the nine treatment options available, the number of optimal choices for individual patient segments were limited based on their prior history, including those with cardiometabolic and cardiovascular comorbidities (four); experiencing prolactin elevation-related problems (seven); needing to avoid excessive sedation (four); or at risk of extrapyramidal symptoms or akathisia (two). Options were then further restricted among patients in more than one segment when multiple pre-index AE

  18. Management options for recycling radioactive scrap metals

    SciTech Connect

    Dehmel, J.C.; MacKinney, J.; Bartlett, J.

    1997-02-01

    The feasibility and advantages of recycling radioactive scrap metals (RSM) have yet to be assessed, given the unique technical, regulatory, safety, and cost-benefit issues that have already been raised by a concerned recycling industry. As is known, this industry has been repeatedly involved with the accidental recycling of radioactive sources and, in some cases, with costly consequences. If recycling were deemed to be a viable option, it might have to be implemented with regulatory monitoring and controls. Its implementation may have to consider various and complex issues and address the requirements and concerns of distinctly different industries. There are three basic options for the recycling of such scraps. They are: (1) recycling through the existing network of metal-scrap dealers and brokers, (2) recycling directly and only with specific steelmills, or (3) recycling through regional processing centers. Under the first option, scrap dealers and brokers would receive material from RSM generators and determine at which steelmills such scraps would be recycled. For the second option, RSM generators would deal directly with selected steelmills under specific agreements. For the third option, generators would ship scraps only to regional centers for processing and shipment to participating steelmills. This paper addresses the potential advantages of each option, identifies the types of arrangements that would need to be secured among all parties, and attempts to assess the receptivity of the recycling industry to each option.

  19. Processing of strong-motion accelerograms: Needs, options and consequences

    USGS Publications Warehouse

    Boore, D.M.; Bommer, J.J.

    2005-01-01

    Recordings from strong-motion accelerographs are of fundamental importance in earthquake engineering, forming the basis for all characterizations of ground shaking employed for seismic design. The recordings, particularly those from analog instruments, invariably contain noise that can mask and distort the ground-motion signal at both high and low frequencies. For any application of recorded accelerograms in engineering seismology or earthquake engineering, it is important to identify the presence of this noise in the digitized time-history and its influence on the parameters that are to be derived from the records. If the parameters of interest are affected by noise then appropriate processing needs to be applied to the records, although it must be accepted from the outset that it is generally not possible to recover the actual ground motion over a wide range of frequencies. There are many schemes available for processing strong-motion data and it is important to be aware of the merits and pitfalls associated with each option. Equally important is to appreciate the effects of the procedures on the records in order to avoid errors in the interpretation and use of the results. Options for processing strong-motion accelerograms are presented, discussed and evaluated from the perspective of engineering application. ?? 2004 Elsevier Ltd. All rights reserved.

  20. Sand control completion options for horizontal wells in soft formations

    SciTech Connect

    Penberthy, W.

    1999-02-01

    Sand control is required in most soft formations. So far, stand-alone screens have been the primary method. From completion, productivity and longevity perspectives, a high percentage of horizontal oil wells have not achieved the desired result: a sand-free, high sustained-productivity producer. Gas wells seem to have fared better. Disappointments have prompted some companies to reassess procedures and strategies involved with horizontal wells in these reservoirs. Gravel packing offers another option for completing horizontal wells, with the advantage of enhancing productivity. Gravel packing provides a means of filling and stabilizing the wellbore with high-permeability gravel, thereby avoiding the plugging and erosion noted with stand-alone screens. Recently, several operators have performed horizontal gravel packs after experiencing unacceptable performance with stand-alone screens. While each completion option has advantages and disadvantages, all have applications. Some are best suited to particular reservoirs, and as a consequence, the applicability of each completion technique must be assessed in light of particular reservoir conditions and reserves. This discussion will review various applications of soft rock completion technology in horizontal service, along with benefits and shortfalls.

  1. Community perspectives

    NASA Technical Reports Server (NTRS)

    1975-01-01

    General aviation is considered from the perspective of the local community's decision-making process in determining its needs for access to general aviation services. The decision-making model, preliminary decision, community characteristics, and planning processes are discussed.

  2. Multirole cargo aircraft options and configurations

    NASA Technical Reports Server (NTRS)

    Conner, D. W.; Vaughan, J. C., III

    1979-01-01

    The paper discusses multirole cargo aircraft options and configurations. It was shown that derivatives of current wide-body aircraft would be economically attractive through 2008, but new dedicated airfreighters incorporating 1990 technology would offer little or no economic incentive. Option studies indicate that Mach 0.7 propfans would be economically attractive in trip cost, aircraft price, and airline ROI; spanloaders would be lower priced with higher ROI, but would have a relatively higher trip cost because of aerodynamic inefficiencies. Finally, air cushion landing gear configurations are identified as an option for avoiding runway constraints on airport accommodation of very large airfreighters.

  3. Training Serials Specialists: Internships as an Option.

    ERIC Educational Resources Information Center

    Meiseles, Linda; Feller, Sue

    1994-01-01

    Discusses the lack of qualified, experienced serials librarians; suggests recruiting support staff from within technical services departments; and describes an internship program developed at Hofstra University (New York) to help train a library school student in serials work. The manager's perspective, the student's perspective, and an evaluation…

  4. Brazil: Energy Options and Current Outlook

    ERIC Educational Resources Information Center

    Goldemberg, J.

    1978-01-01

    Brazil's energy options and current outlook are examined, and a summary of known reserves of fossil and renewable energy resources is given. Suggestions for an energy program designed to preserve Brazilian culture are included. (MDR)

  5. TECHNOLOGICAL OPTIONS FOR ACID RAIN CONTROL

    EPA Science Inventory

    Discussed are acid rain control options available to the electric utility industry. They include coal switching, flue gas desulfurization, and such emerging lower cost technologies as Limestone Injection Multistage Burners (LIMB) and Advanced Silicate (ADVACATE), both developed ...

  6. 24 CFR 221.770 - Assignment option.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... November 30, 1983 (or, in the Direct Endorsement program, a property appraisal report signed by the mortgagee's approved underwriter on or before November 30, 1983) has the option to assign, transfer and...

  7. Treatment Option Overview (Adult Acute Lymphoblastic Leukemia)

    MedlinePlus

    ... recovery) and treatment options. Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the ... to radiation may increase the risk of developing ALL. Anything that increases your risk of getting a ...

  8. Treatment Option Overview (Childhood Acute Lymphoblastic Leukemia)

    MedlinePlus

    ... recovery) and treatment options. Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the ... genetic conditions affect the risk of having childhood ALL. Anything that increases your risk of getting a ...

  9. Treatment Options for Adult Acute Lymphoblastic Leukemia

    MedlinePlus

    ... recovery) and treatment options. Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the ... to radiation may increase the risk of developing ALL. Anything that increases your risk of getting a ...

  10. Treatment Options for Childhood Acute Lymphoblastic Leukemia

    MedlinePlus

    ... recovery) and treatment options. Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the ... genetic conditions affect the risk of having childhood ALL. Anything that increases your risk of getting a ...

  11. A Film Study Option for HSC French

    ERIC Educational Resources Information Center

    Connole, Pat

    1974-01-01

    In 1974, after a trial period of two years, the study of two selected French feature films will be offered as an option to the study of prescribed texts in Higher School Certificate French in Victoria. (Author)

  12. Evaluating State Options for Reducing Medicaid Churning

    PubMed Central

    Swartz, Katherine; Short, Pamela Farley; Graefe, Deborah R.; Uberoi, Namrata

    2015-01-01

    Medicaid churning - the constant exit and re-entry of beneficiaries as their eligibility changes - has long been a problem for both Medicaid administrators and recipients. Churning will continue under the Affordable Care Act, because despite new federal rules, Medicaid eligibility will continue to be based on current monthly income. We developed a longitudinal simulation model to evaluate four policy options for modifying or extending Medicaid eligibility to reduce churning. The simulations suggest that two options, extending Medicaid eligibility either to the end of a calendar year or for twelve months after enrollment, would be far more effective in reducing churning than the other options of a three-month extension or eligibility based on projected annual income. States should consider implementation of the option that best balances costs, including both administration and services, with improved health of Medicaid enrollees. PMID:26153313

  13. TECHNOLOGICAL OPTIONS FOR ACID RAIN CONTROL

    EPA Science Inventory

    Discussed are acid rain control options available to the electric utility industry. They include coal switching, flue gas desulfurization, and such emerging lower cost technologies as Limestone Injection Multistage Burners (LIMB) and Advanced Silicate (ADVACATE), both developed ...

  14. Optional games on cycles and complete graphs.

    PubMed

    Jeong, Hyeong-Chai; Oh, Seung-Yoon; Allen, Benjamin; Nowak, Martin A

    2014-09-07

    We study stochastic evolution of optional games on simple graphs. There are two strategies, A and B, whose interaction is described by a general payoff matrix. In addition, there are one or several possibilities to opt out from the game by adopting loner strategies. Optional games lead to relaxed social dilemmas. Here we explore the interaction between spatial structure and optional games. We find that increasing the number of loner strategies (or equivalently increasing mutational bias toward loner strategies) facilitates evolution of cooperation both in well-mixed and in structured populations. We derive various limits for weak selection and large population size. For some cases we derive analytic results for strong selection. We also analyze strategy selection numerically for finite selection intensity and discuss combined effects of optionality and spatial structure.

  15. Brazil: Energy Options and Current Outlook

    ERIC Educational Resources Information Center

    Goldemberg, J.

    1978-01-01

    Brazil's energy options and current outlook are examined, and a summary of known reserves of fossil and renewable energy resources is given. Suggestions for an energy program designed to preserve Brazilian culture are included. (MDR)

  16. Space options for tropical cyclone hazard mitigation

    NASA Astrophysics Data System (ADS)

    Dicaire, Isabelle; Nakamura, Ryoko; Arikawa, Yoshihisa; Okada, Kazuyuki; Itahashi, Takamasa; Summerer, Leopold

    2015-02-01

    This paper investigates potential space options for mitigating the impact of tropical cyclones on cities and civilians. Ground-based techniques combined with space-based remote sensing instrumentation are presented together with space-borne concepts employing space solar power technology. Two space-borne mitigation options are considered: atmospheric warming based on microwave irradiation and laser-induced cloud seeding based on laser power transfer. Finally technology roadmaps dedicated to the space-borne options are presented, including a detailed discussion on the technological viability and technology readiness level of our proposed systems. Based on these assessments, the space-borne cyclone mitigation options presented in this paper may be established in a quarter of a century.

  17. How to Find Gluten-Free Options

    MedlinePlus

    ... Men For Women For Seniors How to Find Gluten-Free Options Reviewed by Sharon Denny, MS, RDN ... Email Digital Vision/DigitalVision/Thinkstock When considering a gluten-free diet, it is not necessary to avoid ...

  18. Synthesis of Adaptation Options for Coastal Areas

    EPA Pesticide Factsheets

    Adaptation can help reduce the long-term costs associated with climate change. This document provides an introduction to climate change impacts and adaptation options for estuaries, beaches and coastal areas.

  19. Remind me again what disease we are studying? A population genetics, genetic analysis, and real data perspective on why progress on identifying genetic influences on common epilepsies has been so slow.

    PubMed

    Greenberg, David A; Stewart, William L

    2014-01-01

    In this chapter, we will use the concepts and perspective of population genetics and genetic analysis to discuss the trends that are currently popular in the epilepsy genetics literature. We will also show that some of the recent approaches to understanding epilepsy genetics are unlikely to lead to insight into the causes of the most common epilepsies. Much effort has been directed toward very rare influences on epilepsy expression and away from approaches that could shed light on the most heritable epilepsies. The latest genetic technology, e.g., exome sequencing and copy number variants (CNV) analysis, has been applied without proper consideration of the important principles of population genetics, inheritance, or phenotype definition that are critical in common disease studies. We will show that ignoring these issues has led to unlikely suppositions about etiology and about which genes should be pursued. We also suggest that, taken together, the existing evidence supports a neurodevelopmental origin for common epilepsies. We recommend a return to thorough phenotype definition and family studies and a more careful and thoughtful application of the new technology.

  20. Options for rural electrification in Mexico

    SciTech Connect

    Vera, J.G. )

    1992-09-01

    This paper summarizes a study which examined 19 commercially available options for electrifying remote communities in Mexico. Characteristics of a typical community are defined and, using 7 of the technologies, power systems are designed capable of supporting this community. The performance of these systems is evaluated with respect to their ability to satisfy 11 technical design objectives, 5 socioeconomic objectives, and their impact on the environment. A photovoltaic- diesel generator hybrid system with wind generator option is recommended for the typical community.

  1. Suppressing ghost beams: Backlink options for LISA

    NASA Astrophysics Data System (ADS)

    Isleif, K.-S.; Gerberding, O.; Penkert, D.; Fitzsimons, E.; Ward, H.; Robertson, D.; Livas, J.; Mueller, G.; Reiche, J.; Heinzel, G.; Danzmann, K.

    2017-05-01

    In this article we discuss possible design options for the optical phase reference system, the so called backlink, between two moving optical benches in a LISA satellite. The candidates are based on two approaches: Fiber backlinks, with additional features like mode cleaning cavities and Faraday isolators, and free beam backlinks with angle compensation techniques. We will indicate dedicated ghost beam mitigation strategies for the design options and we will point out critical aspects in case of an implementation in LISA.

  2. Managing financial risk with options on futures.

    PubMed

    Bond, M T; Marshall, B S

    1995-05-01

    With the rise of managed care and capitation, more providers will be sharing in the financial risk of providing care. To help protect their organizations from the risk of unexpectedly high utilization under such a fixed-payment system, healthcare financial managers soon will be able to use options on futures contracts. These contracts provide wide profit potential but limited loss potential. Before investing in options on futures, however, healthcare financial managers should consider issues such as basis risk and trading costs.

  3. Female pattern alopecia: current perspectives.

    PubMed

    Levy, Lauren L; Emer, Jason J

    2013-08-29

    Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown (increased part width) and sparing of the frontal hairline (Ludwig classification). Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications - minoxidil and finasteride - are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications. Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens (eg, spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride), prostaglandin analogs (eg, bimatoprost, latanoprost), and ketoconazole are reported to be beneficial. Laser and light therapies have also become popular despite the lack of a profound benefit. Management of expectations is crucial, and the aim of therapy, given the current therapeutic options, is to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. This article reviews current perspectives on therapeutic options for female pattern hair loss.

  4. Female pattern alopecia: current perspectives

    PubMed Central

    Levy, Lauren L; Emer, Jason J

    2013-01-01

    Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown (increased part width) and sparing of the frontal hairline (Ludwig classification). Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications – minoxidil and finasteride – are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications. Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens (eg, spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride), prostaglandin analogs (eg, bimatoprost, latanoprost), and ketoconazole are reported to be beneficial. Laser and light therapies have also become popular despite the lack of a profound benefit. Management of expectations is crucial, and the aim of therapy, given the current therapeutic options, is to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. This article reviews current perspectives on therapeutic options for female pattern hair loss. PMID:24039457

  5. A hybrid modeling approach for option pricing

    NASA Astrophysics Data System (ADS)

    Hajizadeh, Ehsan; Seifi, Abbas

    2011-11-01

    The complexity of option pricing has led many researchers to develop sophisticated models for such purposes. The commonly used Black-Scholes model suffers from a number of limitations. One of these limitations is the assumption that the underlying probability distribution is lognormal and this is so controversial. We propose a couple of hybrid models to reduce these limitations and enhance the ability of option pricing. The key input to option pricing model is volatility. In this paper, we use three popular GARCH type model for estimating volatility. Then, we develop two non-parametric models based on neural networks and neuro-fuzzy networks to price call options for S&P 500 index. We compare the results with those of Black-Scholes model and show that both neural network and neuro-fuzzy network models outperform Black-Scholes model. Furthermore, comparing the neural network and neuro-fuzzy approaches, we observe that for at-the-money options, neural network model performs better and for both in-the-money and an out-of-the money option, neuro-fuzzy model provides better results.

  6. Comparative analyses of spent nuclear fuel transport modal options: Transport options under existing site constraints

    SciTech Connect

    Brentlinger, L.A.; Hofmann, P.L.; Peterson, R.W.

    1989-08-01

    The movement of nuclear waste can be accomplished by various transport modal options involving different types of vehicles, transport casks, transport routes, and intermediate intermodal transfer facilities. A series of systems studies are required to evaluate modal/intermodal spent fuel transportation options in a consistent fashion. This report provides total life-cycle cost and life-cycle dose estimates for a series of transport modal options under existing site constraints. 14 refs., 7 figs., 28 tabs.

  7. 48 CFR 17.202 - Use of options.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Evaluation of Options, in the solicitation. (See 17.207(f) with regard to the exercise of options.) (b... unless (i) the basic quantity is a learning or testing quantity and (ii) competition for the option is...

  8. Real Estate Education: A Curriculum Guide for a Two-Year Post-Secondary Program. (Revised Edition).

    ERIC Educational Resources Information Center

    Overton, R. Jean

    This curriculum guide was designed for associate degree programs and/or options for real estate education in the North Carolina Community College System. Chapter I considers: (1) real estate education in the system; (2) definitions of terms; (3) the benefits of advisory committees; (4) the system's objectives for real estate education and the…

  9. Real Estate Education: A Curriculum Guide for a Two-Year Post-Secondary Program. (Revised Edition).

    ERIC Educational Resources Information Center

    Overton, R. Jean

    This curriculum guide was designed for associate degree programs and/or options for real estate education in the North Carolina Community College System. Chapter I considers: (1) real estate education in the system; (2) definitions of terms; (3) the benefits of advisory committees; (4) the system's objectives for real estate education and the…

  10. Least cost planning from a customer's perspective

    SciTech Connect

    Sutherland, R.J.

    1992-03-02

    In this paper, I offer some thoughts about least cost planning, not from the perspective of the regulator or utility, but from the perspective of a residential customer. The problem that I address is, as a homeowner in northern Virginia, I am about to make a long term fuel choice for my household, where the options include, natural gas, electricity and fuel oil. An additional choice is the energy efficiency capital investment in my home that could decrease my monthly fuel costs. My decision process, hopefully as a rational consumer, offers implications about the efficiency of various services provided by all three fuel suppliers, including the local natural gas distribution companies (LDC).

  11. Error analyses reveal contrasting deficits in "theory of mind": neuropsychological evidence from a 3-option false belief task.

    PubMed

    Samson, Dana; Apperly, Ian A; Humphreys, Glyn W

    2007-06-18

    Perspective taking is a crucial ability that guides our social interactions. In this study, we show how the specific patterns of errors of brain-damaged patients in perspective taking tasks can help us further understand the factors contributing to perspective taking abilities. Previous work [e.g., Samson, D., Apperly, I. A., Chiavarino, C., & Humphreys, G. W. (2004). Left temporoparietal junction is necessary for representing someone else's belief. Nature Neuroscience, 7, 499-500; Samson, D., Apperly, I. A., Kathirgamanathan, U., & Humphreys, G. W. (2005). Seeing it my way: A case of a selective deficit in inhibiting self-perspective. Brain, 128, 1102-1111] distinguished two components of perspective taking: the ability to inhibit our own perspective and the ability to infer someone else's perspective. We assessed these components using a new nonverbal false belief task which provided different response options to detect three types of response strategies that participants might be using: a complete and spared belief reasoning strategy, a reality-based response selection strategy in which participants respond from their own perspective, and a simplified mentalising strategy in which participants avoid responding from their own perspective but rely on inaccurate cues to infer the other person's belief. One patient, with a self-perspective inhibition deficit, almost always used the reality-based response strategy; in contrast, the other patient, with a deficit in taking other perspectives, tended to use the simplified mentalising strategy without necessarily transposing her own perspective. We discuss the extent to which the pattern of performance of both patients could relate to their executive function deficit and how it can inform us on the cognitive and neural components involved in belief reasoning.

  12. Paternalism, autonomy and reciprocity: ethical perspectives in encounters with patients in psychiatric in-patient care.

    PubMed

    Pelto-Piri, Veikko; Engström, Karin; Engström, Ingemar

    2013-12-06

    Psychiatric staff members have the power to decide the options that frame encounters with patients. Intentional as well as unintentional framing can have a crucial impact on patients' opportunities to be heard and participate in the process. We identified three dominant ethical perspectives in the normative medical ethics literature concerning how doctors and other staff members should frame interactions in relation to patients; paternalism, autonomy and reciprocity. The aim of this study was to describe and analyse statements describing real work situations and ethical reflections made by staff members in relation to three central perspectives in medical ethics; paternalism, autonomy and reciprocity. All staff members involved with patients in seven adult psychiatric and six child and adolescent psychiatric clinics were given the opportunity to freely describe ethical considerations in their work by keeping an ethical diary over the course of one week and 173 persons handed in their diaries. Qualitative theory-guided content analysis was used to provide a description of staff encounters with patients and in what way these encounters were consistent with, or contrary to, the three perspectives. The majority of the statements could be attributed to the perspective of paternalism and several to autonomy. Only a few statements could be attributed to reciprocity, most of which concerned staff members acting contrary to the perspective. The result is presented as three perspectives containing eight values.•Paternalism; 1) promoting and restoring the health of the patient, 2) providing good care and 3) assuming responsibility.•Autonomy; 1) respecting the patient's right to self-determination and information, 2) respecting the patient's integrity and 3) protecting human rights.•Reciprocity; 1) involving patients in the planning and implementation of their care and 2) building trust between staff and patients. Paternalism clearly appeared to be the dominant

  13. NASA's EOSDIS: options for data providers

    NASA Astrophysics Data System (ADS)

    Khalsa, Siri J.; Ujhazy, John E.

    1995-12-01

    EOSDIS, the data and information system being developed by NASA to support interdisciplinary earth science research into the 21st century, will do more than manage and distribute data from EOS-era satellites. It will also promote the exchange of data, tools, and research results across disciplinary, agency, and national boundaries. This paper describes the options that data providers will have for interacting with the EOSDIS Core System (ECS), the infrastructure of EOSDIS. The options include: using the ECS advertising service to announce the availability of data at the provider's site; submitting a candidate data set to one of the Distributed Active Archive Centers (DAACs); establishing a data server that will make the data accessible via ECS and establishing Local Information Manager (LIM) which would make the data available for multi-site searches. One additional option is through custom gateway interfaces which would provide access to existing data archives. The gateway, data server, and LIM options require the implementation of ECS code at the provider site to insure proper protocols. The advertisement and ingest options require no part of ECS design to reside at the provider site.

  14. Disposition options for {sup 233}U

    SciTech Connect

    Forsberg, C.W.; Icenhour, A.S.; Krichinsky, A.M.

    1998-04-27

    The United States is implementing a program to dispose of excess nuclear-weapons-usable materials--including {sup 233}U. A series of studies have identified multiple {sup 233}U disposition options, and these options are described herein. Most of the options involve adding depleted uranium containing {sup 238}U to the {sup 233}U. Converting the {sup 233}U into a mixture of <12 wt % {sup 233}U in {sup 238}U converts the weapons-usable {sup 233}U into nonweapons-usable {sup 233}U. For {sup 233}U that is considered waste, further isotopic dilution to <0.66 wt % {sup 233}U in {sup 238}U minimizes potential long-term repository criticality concerns and in many cases minimizes final waste volumes.

  15. Particle separation options for emergency water treatment.

    PubMed

    Dorea, C C; Bertrand, S; Clarke, B A

    2006-01-01

    Emergencies can result from the effects of unpredictable natural forces or from the cruelty of conflicts. The affected population is often left vulnerable to increased health risks. The victims' exposure to these risks can be reduced by timely public health interventions. Often, one of the first basic mitigations is the provision of water for essential needs. The quickest option, and generally more polluted, is of surface waters. We have reviewed particle separation options for emergency water treatment of surface waters. These vary from granular filtration package treatment facilities to ceramic candle filters and have therefore been broadly classified in three categories: modular, mobile and point-of-use (or household). The operational requirements and process limitations that can influence the choice of each option are discussed alongside with their underlying particle separation mechanisms and performance data.

  16. Lattice Design for ERL Options at SLAC

    SciTech Connect

    Nosochkov, Yuri; Cai, Yunhai; Huang, Xiaobiao; Wang, Min-Huey; /SLAC

    2011-06-02

    SLAC is investigating long-range options for building a high performance light source machine while reusing the existing linac and PEP-II tunnels. One previously studied option is the PEP-X low emittance storage ring. The alternative option is based on a superconducting Energy Recovery Linac (ERL) and the PEP-X design. The ERL advantages are the low beam emittance, short bunch length and small energy spread leading to better qualities of the X-ray beams. Two ERL configurations differed by the location of the linac have been studied. Details of the lattice design and the results of beam transport simulations with the coherent synchrotron radiation effects are presented.

  17. Valuating Privacy with Option Pricing Theory

    NASA Astrophysics Data System (ADS)

    Berthold, Stefan; Böhme, Rainer

    One of the key challenges in the information society is responsible handling of personal data. An often-cited reason why people fail to make rational decisions regarding their own informational privacy is the high uncertainty about future consequences of information disclosures today. This chapter builds an analogy to financial options and draws on principles of option pricing to account for this uncertainty in the valuation of privacy. For this purpose, the development of a data subject's personal attributes over time and the development of the attribute distribution in the population are modeled as two stochastic processes, which fit into the Binomial Option Pricing Model (BOPM). Possible applications of such valuation methods to guide decision support in future privacy-enhancing technologies (PETs) are sketched.

  18. Exploration Architecture Options - ECLSS, TCS, EVA Implications

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Henninger, Don

    2011-01-01

    Many options for exploration of space have been identified and evaluated since the Vision for Space Exploration (VSE) was announced in 2004. The Augustine Commission evaluated human space flight for the Obama administration then the Human Exploration Framework Teams (HEFT and HEFT2) evaluated potential exploration missions and the infrastructure and technology needs for those missions. Lunar architectures have been identified and addressed by the Lunar Surface Systems team to establish options for how to get to, and then inhabit and explore, the moon. This paper will evaluate the options for exploration of space for the implications of architectures on the Environmental Control and Life Support (ECLSS), Thermal Control (TCS), and Extravehicular Activity (EVA) Systems.

  19. Environmental performance of algal biofuel technology options.

    PubMed

    Vasudevan, Venkatesh; Stratton, Russell W; Pearlson, Matthew N; Jersey, Gilbert R; Beyene, Abraham G; Weissman, Joseph C; Rubino, Michele; Hileman, James I

    2012-02-21

    Considerable research and development is underway to produce fuels from microalgae, one of several options being explored for increasing transportation fuel supplies and mitigating greenhouse gas emissions (GHG). This work models life-cycle GHG and on-site freshwater consumption for algal biofuels over a wide technology space, spanning both near- and long-term options. The environmental performance of algal biofuel production can vary considerably and is influenced by engineering, biological, siting, and land-use considerations. We have examined these considerations for open pond systems, to identify variables that have a strong influence on GHG and freshwater consumption. We conclude that algal biofuels can yield GHG reductions relative to fossil and other biobased fuels with the use of appropriate technology options. Further, freshwater consumption for algal biofuels produced using saline pond systems can be comparable to that of petroleum-derived fuels.

  20. Takeoff Performance Monitoring System display options

    NASA Technical Reports Server (NTRS)

    Middleton, David B.; Srivatsan, Raghavachari; Person, Lee H., Jr.

    1992-01-01

    The development of displays for the Takeoff Performance Monitoring System (TPMS) is described with attention given to the three concepts prepared for commercial applications. The TPMS algorithm is described and related to the display requirements for pilots of two-engine airplanes. Head-up and -down displays are considered for displaying the simple advisory data which indicate whether the takeoff is a 'Go' or 'No-go' based on engine failure, acceleration error, and runway length. Six pilots are shown the three display options which include: (1) basic information; (2) basic data with 'Go/No-go' advisory flags; and (3) basic data, advisory flags, and an abort-warning symbol. The pilots tended to select the option with the most advisory data available, but the inconclusive preference study led to the concept of presenting all three configurations as possible display options for the TPMS.